Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.
Impairment of the ability to coordinate the movements required for normal ambulation (WALKING) which may result from impairments of motor function or sensory feedback. This condition may be associated with BRAIN DISEASES (including CEREBELLAR DISEASES and BASAL GANGLIA DISEASES); SPINAL CORD DISEASES; or PERIPHERAL NERVOUS SYSTEM DISEASES.
Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of diadochokinesis (rapidly alternating movements), and GAIT ATAXIA. (From Adams et al., Principles of Neurology, 6th ed, p90)
The coordination of a sensory or ideational (cognitive) process and a motor activity.

Non-motor associative learning in patients with isolated degenerative cerebellar disease. (1/486)

In recent decades it has become clear that the cerebellum is involved in associative motor learning, but its exact role in motor learning as such is still controversial. Recently, a contribution of the cerebellum to different cognitive abilities has also been considered, but it remains unclear whether the cerebellum contributes to cognitive associative learning. We compared nine patients with an isolated cerebellar degenerative disease in a cognitive associative learning task with 10 controls. Patients and controls were matched for age, sex, handedness, level of education, intelligence and capabilities of visual memory. The subjects were asked to learn the association between six pairs of colours and numerals by trial and error. Additionally, a simple reaction time and a visual scanning test were conducted in order to control for the influence of motor performance deficits in cerebellar patients. In comparison with the controls, it took the patients significantly longer to learn the correct associations between colours and numerals, and they were impaired in recognizing them later on. Two patients showed no associative learning effect at all. Neither the simple reaction time nor the visual scanning time correlated substantially with the results of associative learning. Therefore, motor-associated disabilities are unlikely to be the reason for the learning deficit in cerebellar patients. Our results suggest that the cerebellum might contribute to motor-independent processes that are generally involved in associative learning.  (+info)

Contralateral deafness following unilateral suboccipital brain tumor surgery in a patient with large vestibular aqueduct--case report. (2/486)

A 68-year-old female developed contralateral deafness following extirpation of a left cerebellopontine angle epidermoid cyst. Computed tomography showed that large vestibular aqueduct was present. This unusual complication may have been caused by an abrupt pressure change after cerebrospinal fluid release, which was transmitted through the large vestibular aqueduct and resulted in cochlear damage.  (+info)

Anticonvulsant-induced dyskinesias: a comparison with dyskinesias induced by neuroleptics. (3/486)

Anticonvulsants cause dyskinesias more commonly than has been appreciated. Diphenylhydantoin (DPH), carbamazepine, primidone, and phenobarbitone may cause asterixis. DPH, but not other anticonvulsants, may cause orofacial dyskinesias, limb chorea, and dystonia in intoxicated patients. These dyskinesias are similar to those caused by neuroleptic drugs and may be related to dopamine antagonistic properties possessed by DPH.  (+info)

Intrameatal aneurysm successfully treated by meatal loop trapping--case report. (4/486)

A 77-year-old female presented with a rare intrameatal aneurysm manifesting as sudden onset of headache, hearing loss, tinnitus, and vertigo associated with subarachnoid hemorrhage. Meatal loop trapping was performed. After surgery, the patient's functions recovered almost completely, probably because of the preservation of the 7th and 8th cranial nerves and the presence of effective collaterals in the area supplied by the anterior inferior cerebellar artery.  (+info)

Remote regional cerebral blood flow consequences of focused infarcts of the medulla, pons and cerebellum. (5/486)

The aim of this study was to evaluate regional and remote diaschisis of inferior brain stem or cerebellar infarcts in 25 patients presenting with relatively limited lesions. Patients presented with medullary, pontine or cerebellar infarction. METHODS: Lesions were evaluated on MRI (0.5 T). Regional cerebral blood flow (rCBF) was assessed by means of SPECT, after injection of 9rmTc-hexamethyl propyleneamine oxime (HMPAO) and, when possible, inhalation of 133Xe in the same session. For each method, asymmetry indices (Als), comparing contralateral to ipsilateral rCBF values, were calculated in four areas of each cerebral hemisphere and in the cerebellum and later compared with values obtained in healthy subjects (P = 0.05). RESULTS: Higher rCBF values were observed in the contralateral cerebellum in 2 of 7 patients with selective lateral medullary lesions, and cerebellar Als were significantly increased. When a cerebellar infarct was associated with a lateral medullary lesion, the cerebellar and contralateral hemispheric asymmetries were more severe. Unilateral paramedian pontine infarcts had more frequent consequences on the cerebellum (2 of 3 cases), with rCBF or tracer uptake being reduced in the ipsilateral or the contralateral lobe. Inverse cerebral hemispheric asymmetry could then be observed. Bilateral pontine lesions were difficult to evaluate. Using 99mTc-HMPAO, discrete cerebellar asymmetry was observed in 3 of 6 cases. Pure cerebellar infarcts in the posterior inferior cerebellar artery territory were always associated with a severe ipsilateral flow drop in the cerebellum, and contralateral hemispheric diaschisis was frequent (3 of 4 patients), predominating in the frontotemporal cortex and subcortical structures. This was also more obvious using 99mTC-HMPAO than 133Xe. Variance analysis showed that hemispheric diaschisis was more severe in mixed brain stem and cerebellar infarcts than in pure cerebellar or brain stem lesions. Furthermore, cerebellar and hemispheric AI values were not correlated with measurements of clinical deficits, disability or handicap. CONCLUSION: Unilateral and limited inferior brain stem lesions can have ipsi- or contralateral consequences on the cerebellum and cerebral hemispheres rCBF. These remote effects are related to lesions of the main pathways joining these structures, resulting in deactivation and, in some cases, overactivation. Contrary to what has been suggested, consequences on cerebral hemispheres are more severe in mixed cerebellar and brain stem infarcts than in pure cerebellar lesions.  (+info)

Multiple large and small cerebellar infarcts. (6/486)

To assess the clinical, topographical, and aetiological features of multiple cerebellar infarcts,18 patients (16.5% of patients with cerebellar infarction) were collected from a prospective acute stroke registry, using a standard investigation protocol including MRI and magnetic resonance angiography. Infarcts in the posterior inferior cerebellar artery (PICA)+superior cerebellar artery (SCA) territory were most common (9/18; 50%), followed by PICA+anterior inferior cerebellar artery (AICA)+SCA territory infarcts (6/18; 33%). One patient had bilateral AICA infarcts. No infarct involved the PICA+AICA combined territory. Other infarcts in the posterior circulation were present in half of the patients and the clinical presentation largely depended on them. Large artery disease was the main aetiology. Our findings emphasised the common occurrence of very small multiple cerebellar infarcts (<2 cm diameter). These very small multiple cerebellar infarcts may occur with (13 patients/18; 72%) or without (3/18; 22%) territorial cerebellar infarcts. Unlike previous series, they could not all be considered junctional infarcts (between two main cerebellar artery territories: 51/91), but also small territorial infarcts (40/91). It is suggested that these very small territorial infarcts may be endzone infarcts, due to the involvement of small distal arterial branches. It is possible that some very small territorial infarcts may be due to a microembolic process, but this hypothesis needs pathological confirmation.  (+info)

Failure of cerebellar patients to time finger opening precisely causes ball high-low inaccuracy in overarm throws. (7/486)

We investigated the idea that the cerebellum is required for precise timing of fast skilled arm movements by studying one situation where timing precision is required, namely finger opening in overarm throwing. Specifically, we tested the hypothesis that in overarm throws made by cerebellar patients, ball high-low inaccuracy is due to disordered timing of finger opening. Six cerebellar patients and six matched control subjects were instructed to throw tennis balls at three different speeds from a seated position while angular positions in three dimensions of five arm segments were recorded at 1,000 Hz with the search-coil technique. Cerebellar patients threw more slowly than controls, were markedly less accurate, had more variable hand trajectories, and showed increased variability in the timing, amplitude, and velocity of finger opening. Ball high-low inaccuracy was not related to variability in the height or direction of the hand trajectory or to variability in finger amplitude or velocity. Instead, the cause was variable timing of finger opening and thereby ball release occurring on a flattened arc hand trajectory. The ranges of finger opening times and ball release times (timing windows) for 95% of the throws were on average four to five times longer for cerebellar patients; e.g., across subjects mean ball release timing windows for throws made under the medium-speed instruction were 11 ms for controls and 55 ms for cerebellar patients. This increased timing variability could not be explained by disorder in control of force at the fingers. Because finger opening in throwing is likely controlled by a central command, the results implicate the cerebellum in timing the central command that initiates finger opening in this fast skilled multijoint arm movement.  (+info)

Preserved performance by cerebellar patients on tests of word generation, discrimination learning, and attention. (8/486)

Recent theories suggest that the human cerebellum may contribute to the performance of cognitive tasks. We tested a group of adult patients with cerebellar damage attributable to stroke, tumor, or atrophy on four experiments involving verbal learning or attention shifting. In experiment 1, a verb generation task, participants produced semantically related verbs when presented with a list of nouns. With successive blocks of practice responding to the same set of stimuli, both groups, including a subset of cerebellar patients with unilateral right hemisphere lesions, improved their response times. In experiment 2, a verbal discrimination task, participants learned by trial and error to pick the target words from a set of word pairs. When age was taken into account, there were no performance differences between cerebellar patients and control subjects. In experiment 3, measures of spatial attention shifting were obtained under both exogenous and endogenous cueing conditions. Cerebellar patients and control subjects showed similar costs and benefits in both cueing conditions and at all SOAs. In experiment 4, intra- and interdimensional shifts of nonspatial attention were elicited by presenting word cues before the appearance of a target. Performance was substantially similar for cerebellar patients and control subjects. These results are presented as a cautionary note. The experiments failed to provide support for current hypotheses regarding the role of the cerebellum in verbal learning or attention. Alternative interpretations of previous results are discussed.  (+info)

Some common types of cerebellar diseases include:

1. Cerebellar atrophy: This is a condition where the cerebellum shrinks or degenerates, leading to symptoms such as tremors, muscle weakness, and difficulty with movement.
2. Cerebellar degeneration: This is a condition where the cerebellum deteriorates over time, leading to symptoms such as loss of coordination, balance problems, and difficulties with speech and language.
3. Cerebellar tumors: These are abnormal growths that develop in the cerebellum, which can cause a variety of symptoms depending on their size and location.
4. Cerebellar stroke: This is a condition where blood flow to the cerebellum is interrupted, leading to damage to the brain tissue and symptoms such as weakness or paralysis of certain muscle groups.
5. Cerebellar vasculature disorders: These are conditions that affect the blood vessels in the cerebellum, leading to symptoms such as transient ischemic attacks (TIAs) or strokes.
6. Inflammatory diseases: These are conditions that cause inflammation in the cerebellum, leading to symptoms such as tremors, ataxia, and weakness.
7. Infections: Bacterial, viral, or fungal infections can affect the cerebellum and cause a range of symptoms.
8. Trauma: Head injuries or other forms of trauma can damage the cerebellum and lead to symptoms such as loss of coordination, balance problems, and memory loss.
9. Genetic disorders: Certain genetic mutations can affect the development and function of the cerebellum, leading to a range of symptoms.
10. Degenerative diseases: Conditions such as multiple sclerosis, Parkinson's disease, and Huntington's disease can cause degeneration of the cerebellum and lead to symptoms such as tremors, ataxia, and weakness.

It's important to note that this is not an exhaustive list, and there may be other causes of cerebellar symptoms not included here. A healthcare professional can help determine the underlying cause of your symptoms based on a thorough medical history and examination.

The main symptoms of gait ataxia include:

* Unsteadiness
* Lack of coordination
* Wobbling or staggering while walking
* Increased risk of falling
* Difficulty with balance and equilibrium
* Slow and deliberate movements

Gait ataxia can be assessed using various clinical tests such as the Clinical Test of Sensory Integration and Balance, the Berg Balance Scale, and the Timed Up and Go test. Treatment options for gait ataxia depend on the underlying cause of the condition and may include physical therapy, occupational therapy, speech therapy, medications, and in some cases, surgery.

In summary, gait ataxia is a term used to describe an abnormal gait pattern due to dysfunction in the nervous system. It can be caused by various factors and can affect individuals of all ages. The symptoms include unsteadiness, lack of coordination, and increased risk of falling, among others. Treatment options depend on the underlying cause of the condition and may include physical therapy, medications, and in some cases, surgery.

Causes:

* Genetic mutations or deletions
* Infections such as meningitis or encephalitis
* Stroke or bleeding in the brain
* Traumatic head injury
* Multiple sclerosis or other demyelinating diseases
* Brain tumors
* Cerebellar degeneration due to aging

Symptoms:

* Coordination difficulties, such as stumbling or poor balance
* Tremors or shaky movements
* Slurred speech and difficulty with fine motor skills
* Nystagmus (involuntary eye movements)
* Difficulty with gait and walking
* Fatigue, weakness, and muscle wasting

Diagnosis:

* Physical examination and medical history
* Neurological examination to test coordination, balance, and reflexes
* Imaging studies such as MRI or CT scans to rule out other conditions
* Genetic testing to identify inherited forms of cerebellar ataxia
* Electromyography (EMG) to test muscle activity and nerve function

Treatment:

* Physical therapy to improve balance, coordination, and gait
* Occupational therapy to help with daily activities and fine motor skills
* Speech therapy to address slurred speech and communication difficulties
* Medications to manage symptoms such as tremors or spasticity
* Assistive devices such as canes or walkers to improve mobility

Prognosis:

* The prognosis for cerebellar ataxia varies depending on the underlying cause. In some cases, the condition may be slowly progressive and lead to significant disability over time. In other cases, the condition may remain stable or even improve with treatment.

Living with cerebellar ataxia can be challenging, but there are many resources available to help individuals with the condition manage their symptoms and maintain their quality of life. These resources may include:

* Physical therapy to improve balance and coordination
* Occupational therapy to assist with daily activities
* Speech therapy to address communication difficulties
* Assistive devices such as canes or walkers to improve mobility
* Medications to manage symptoms such as tremors or spasticity
* Support groups for individuals with cerebellar ataxia and their families

Overall, the key to managing cerebellar ataxia is early diagnosis and aggressive treatment. With proper management, individuals with this condition can lead active and fulfilling lives despite the challenges they face.

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Parkinson's disease and stroke. More specifically, the neurological diseases that can cause cerebellar degeneration include: ... There are two types of cerebellar degeneration; paraneoplastic cerebellar degeneration, and alcoholic or nutritional cerebellar ... Like any other disease, treatment for cerebellar degeneration is contingent on the underlying cause, unique to each patient. As ... "Cerebellar degeneration". Genetic and Rare Diseases Information Center (GARD) - an NCATS Program. U.S. National Institutes of ...
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Cerebellar development and disease. Curr Opin Neurobiol. 2008 Feb;18(1):12-9. Epub 2008 May 29. Doyon J. Motor sequence ... Parkinson's disease, which affects the basal ganglia, has been shown to cause an impairment in the ability to consolidate new ... This points to the importance of the basal ganglia, the primary target of Parkinson's disease, in creating the new sensory/ ... Cerebellar involvement in anticipating the consequences of self-produced actions during bimanual movements. J Neurophysiol. ...
"Cerebellar development and disease". Curr Opin Neurobiol. 18 (1): 12-9. doi:10.1016/j.conb.2008.05.010. PMC 2474776. PMID ... B. Coronal images showing varying degrees of cerebellar hemispheric (one of two halves of a part of the brain) hypoplasia. ... Pontocerebellar hypoplasia is classified as follows: Pontine and cerebellar hypoplasia is also observed in certain phenotypes ... Mental retardation and microcephaly with pontine and cerebellar hypoplasia Millen KJ, Gleeson JG (February 2008). " ...
Autosomal Recessive Cerebellar Ataxias. May 1, 2013. Orphonet Journal of Rare Diseases. 17 November 2006 This article ... Orphanet Journal of Rare Diseases "Autosomal Recessive Cerebellar Ataxias." Fracis, Palau Beaudin, Marie; Matilla-Dueñas, ... Autosomal recessive cerebellar ataxia type 1 (ARCA1) is a condition characterized by progressive problems with movement. Signs ... Most cases of autosomal recessive cerebellar ataxia are early onset, usually around the age of 20. People with this type of ...
... (CA), also called cerebellar cortical abiotrophy (CCA), is a genetic neurological disease in animals, ... There are other diseases that lead to cerebellar degeneration, but the loss of Purkinje cells is a clear way to diagnose ... 1985). "Cerebellar Disease in Arabian Horses". Proceedings of the 21st annual convention of the American Association of Equine ... Cerebellar abiotrophy in horses was originally thought to be a form of cerebellar hypoplasia (CH) and was described as such in ...
Lechtenberg, R.; Gilman, S. (1978). "Speech Disorders in Cerebellar Disease" (PDF). Ann. Neurol. 3 (4): 285-290. doi:10.1002/ ... Lyme disease Stroke Tay-Sachs disease, and late-onset Tay-Sachs disease (LOTS) Transient ischemic attack, a 'mini stroke' ... Kent, RD; Netsell, R; Abbs, JH (September 1979). "Acoustic characteristics of dysarthria associated with cerebellar disease". J ... Huntington's disease, Niemann-Pick disease, and Friedreich's ataxia.[citation needed] Toxic and metabolic conditions include: ...
... (also known as Der Kaloustian-Jarudi-Khoury syndrome) is an autosomally recessive disease that was ... Medicine portal Rare disease "Orphanet: Corneal cerebellar syndrome". Orphanet. October 2006. Retrieved 18 May 2016. "OMIM ... that the disease is different from a disease known as spastic ataxia-corneal dystrophy syndrome that had been found a year ... Corneal-cerebellar syndrome differs from the spastic ataxia-corneal dystrophy syndrome by causing intellectual disability. ...
Claus, D; Schöcklmann, HO; Dietrich, HJ (1986). "Long latency muscle responses in cerebellar diseases". European Archives of ... Claus, Detlef; Schocklmann, Dietrich (1986). "Long Latency Muscle Responses in Cerebellar Diseases". European Archives of ... Nerve conduction studies can only diagnose diseases on the muscular and nerve level. They cannot detect disease in the spinal ... Aminoff, [edited by] William F. Brown, Charles F. Bolton, Michael J. (2002). Neuromuscular function and disease : basic, ...
"Cerebellar Ataxia in Patients with Mitochondrial DNA Disease". Journal of Neuropathology & Experimental Neurology. 71 (2): 148- ... diabetes Huntington's disease cancer Alzheimer's disease, Parkinson's disease bipolar disorder, schizophrenia, aging and ... Mitochondrial diseases take on unique characteristics both because of the way the diseases are often inherited and because ... Wikimedia Commons has media related to Mitochondrial diseases. Mitochondrial disease at Curlie International Mito Patients (IMP ...
Cerebellar dentate nucleus in Alzheimer's disease with myoclonus. [Article]. Dementia and Geriatric Cognitive Disorders, 10(2 ... Canavan's disease: Canavan's disease is a white matter disease due to aspartoacylase deficiency. The dentate nucleus is not ... the deep cerebellar nuclei form a functional unit that provides feedback control of the cerebellar cortex by cerebellar output ... The deep cerebellar nuclei receive the final output from the cerebellar cortex via Purkinje cells in the form of inhibition. ...
"Autosomal dominant cerebellar ataxia, deafness, and narcolepsy - About the Disease - Genetic and Rare Diseases Information ... "ZFIN Human Disease: autosomal dominant cerebellar ataxia, deafness and narcolepsy". zfin.org. Retrieved 2022-09-09. " ... "Autosomal dominant cerebellar ataxia, deafness, and narcolepsy". "Orphanet: Autosomal dominant cerebellar ataxia deafness ... Autosomal dominant cerebellar ataxia, deafness, and narcolepsy is a rare progressive genetic disorder that primarily affects ...
In cerebellar diseases, the movements are irregular and inaccurate; in case of the pyramidal tract lesion the motion may be ... With cerebellar disease, the forearm may sway in several cycles. The patient may even strike themself if not guarded.[citation ... is characteristic of cerebellar diseases. Many clinical tests may be employed to test for such disturbances. Alternating ...
"Delayed Cerebellar Disease and Death after Accidental Exposure to Dimethylmercury". New England Journal of Medicine. 338 (23): ... Fecal matter in particular as it is known to carry many diseases. Many caregivers use gloves while touching the child's ...
"Delayed Cerebellar Disease and Death after Accidental Exposure to Dimethylmercury". New England Journal of Medicine. 338 (23): ... Methylmercury poisoning is also known as Minamata disease. As early as 1865, two workers in the laboratory of Frankland died ... Diethylmercury Mercury poisoning Minamata disease Methylmercury "dimethylmercury - Compound Summary". PubChem Compound. US: ... A rare case of Minamata disease". Forensic Science, Medicine and Pathology. 16 (3): 504-509. doi:10.1007/s12024-020-00247-y. ...
"Delayed Cerebellar Disease and Death after Accidental Exposure to Dimethylmercury". New England Journal of Medicine. 338 (23): ...
"ZFIN Human Disease: infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly". zfin.org. Retrieved ... "Infantile Cerebral and Cerebellar Atrophy". Jewish Genetic Disease Consortium. Retrieved 2022-07-14. Kaufmann, Rami; ... "Postnatal progressive microcephaly, seizures, and brain atrophy - About the Disease - Genetic and Rare Diseases Information ... Infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly is a rare hereditary autosomal recessive ...
Another rare disease in the breed is neonatal cerebellar cortical degeneration. Affected puppies are slow, have lower co- ... "Neonatal Cerebellar Cortical Degeneration". Animal Health Trust. Archived from the original on 23 March 2013. Retrieved 13 May ... Beagles are considered a chondrodystrophic breed, meaning that they are prone to types of disk diseases. In rare cases, beagles ... "Frequency of the neonatal cerebellar cortical degeneration (NCCD) mutations in beagles in the UK" (PDF). Kennel Club Genetics ...
"Marie's ataxia": an hereditary disease of the nervous system, with cerebellar ataxia. "Marie-Foix-Alajouanine syndrome": ... Named along with German neurologist Adolph Strümpell (1853-1925). The disease is sometimes referred to as "Bekhterev Disease"; ... Charcot-Marie-Tooth disease Archived 2011-05-14 at the Wayback Machine @ Who Named It Tumblety, Joan (2012). Remaking the Male ... His analysis of the disease was an important contribution in the emerging field of endocrinology. Marie is also credited as the ...
2007). "Redefining the disease locus of 16q22.1-linked autosomal dominant cerebellar ataxia". J. Hum. Genet. 52 (8): 643-9. doi ... 2006). "16q-linked autosomal dominant cerebellar ataxia: a clinical and genetic study". J. Neurol. Sci. 247 (2): 180-6. doi: ... 2005). "Fine mapping of 16q-linked autosomal dominant cerebellar ataxia type III in Japanese families". Neurogenetics. 5 (4): ... "An autosomal dominant cerebellar ataxia linked to chromosome 16q22.1 is associated with a single-nucleotide substitution in the ...
Holmes G (1908). "An Attempt to Classify Cerebellar Disease, with a Note on Marie's Hereditary Cerebellar Ataxia". Brain. 30 (4 ... "Psychopathology in patients with degenerative cerebellar diseases: a comparison to Huntington's disease". The American Journal ... An estimated 77% of cases of progressive cerebellar disease are reported to have one or more mental health disorders, and 19% ... Because many SCAs, including SCA1, are polyglutamine diseases and operate by similar mechanisms to Huntington's disease many ...
His wartime observations on gunshot wounds re-awakened his interest in cerebellar disease which led to his classical analysis ... Holmes' observations on gunshot wounds re-awakened his interest in cerebellar disease; this culminated in his classical ... In 1906 he was appointed Physician to the National Hospital for Nervous Diseases, Queen Square, London. At the outbreak of the ... Holmes therefore returned to London and became a resident medical officer at the National Hospital for Nervous Diseases in ...
Chapter 10, "Cerebellar Disease." Elsevier. Nedzelski JM (October 1983). "Cerebellopontine angle tumors: bilateral flocculus ... a tumor of the meninges or membranes that surround the nerves passing through the CPA Cerebellar astrocytoma, a malignant tumor ... Hypertrophic pachymeningitis secondary to IgG4-related disease: case report and review of the literature]". Revista de ...
"Porencephaly cerebellar hypoplasia internal malformations - About the Disease - Genetic and Rare Diseases Information Center". ... Porencephaly-cerebellar hypoplasia-internal malformations syndrome is a rare autosomal recessive syndrome that mainly affects ... "Orphanet: Porencephaly cerebellar hypoplasia internal malformations syndrome". www.orpha.net. Archived from the original on ... "Porencephaly-cerebellar hypoplasia-internal malformations syndrome (Concept Id: C1832472) - MedGen - NCBI". www.ncbi.nlm.nih. ...
"The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar dysfunction". Ann. Neurol. 53 (1): 123-127 ...
CT may show ventricular enlargement due to cerebellar atrophy and white matter disease. Brain biopsy may be necessary to ... Rare diseases, Slow virus diseases, Rare infectious diseases). ... Progression of the disease can be divided into two stages:[ ... the disease can be managed with anticonvulsants, physiotherapy, etc.[citation needed] PRP is very rare and similar to SSPE but ... sometimes myoclonic cerebellar ataxia spastic weakness retinopathy, optic atrophy frank dementia leading to coma spasticity and ...
ET cases that progress to Parkinson's disease are less likely to have had cerebellar problems. Recent neuroimaging studies have ... Louis ED (2014). "'Essential tremor' or 'the essential tremors': is this one disease or a family of diseases?". ... cerebrovascular disease, abnormal bleeding, hemorrhage and/or blood clotting disorders, advanced kidney disease or on dialysis ... Tremor and disease activity/intensity can worsen in response to fatigue, strong emotions, low blood sugar, cold and heat, ...
... s suffer from an inherited disease, cerebellar ataxia, forcing people to euthanize many puppies. This has been ... Mutant cells suffer disruptions in their endoplasmic reticula, leading to disease. It is hoped that a test will be developed to ... "A SEL1L Mutation Links a Canine Progressive Early-Onset Cerebellar Ataxia to the Endoplasmic Reticulum-Associated Protein ...
"Infantile cerebellar retinal degeneration - About the Disease - Genetic and Rare Diseases Information Center". rarediseases. ... "Orphanet: Infantile cerebellar retinal degeneration". "Infantile Cerebellar-Retinal Degeneration , Hereditary Ocular Diseases ... "Rare Disease Series #17: Infantile Cerebellar-retinal Degeneration". 3billion Blog. 2021-01-15. Retrieved 2022-05-04. Ha, Dong ... Infantile cerebellar retinal degeneration is a rare hereditary neurological disorder which primarily affects the eyes and the ...
Cerebellar hypoplasia in association with hydrocephalus can constitute Dandy-Walker malformation, which is found in a number of ... Strømme syndrome therefore falls under the classification of diseases known as ciliopathies. Mutations that have been ... "Strømme Syndrome , Hereditary Ocular Diseases". disorders.eyes.arizona.edu. Archived from the original on 24 July 2017. ...
"Role of Neuroimaging on Differentiation of Parkinson's Disease and Its Related Diseases". Yonago Acta Medica (Review). 61 (3): ... Both MRI and CT scanning may show a decrease in the size of the cerebellum and pons in those with cerebellar features (MSA-C). ... The disease progresses without remission at a variable rate. Those who present at an older age, those with parkinsonian ... As the disease progresses one of three groups of symptoms predominates. These are:[citation needed] Parkinsonism - slow, stiff ...
Burnier M (2008). Sodium In Health And Disease. CRC Press. p. 15. ISBN 978-0-8493-3978-3. Chin AC, Gao Z, Riley AM, Furkert D, ... The Na⁺-K⁺ pump has been shown to control and set the intrinsic activity mode of cerebellar Purkinje neurons, accessory ... In certain conditions such as in the case of cardiac disease, the Na⁺/K⁺-ATPase may need to be inhibited via pharmacological ... Alcohol inhibits sodium-potassium pumps in the cerebellum and this is likely how it corrupts cerebellar computation and body ...
... dominant pure Cerebellar degeneration Cerebellar degeneration, subacute Cerebellar hypoplasia Cerebellar hypoplasia endosteal ... Marie-Tooth disease type 1A Charcot-Marie-Tooth disease type 1B Charcot-Marie-Tooth disease type 1C Charcot-Marie-Tooth disease ... Marie-Tooth disease type 2C Charcot-Marie-Tooth disease type 2D Charcot-Marie-Tooth disease type 4A Charcot-Marie-Tooth disease ... Tooth disease Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease deafness dominant type Charcot-Marie-Tooth disease ...
... (Zhu-Tokita-Takenouchi-Kim syndrome) is a rare disease caused in humans by a genetic mutation of the SON gene. ... hypoplasia of the corpus callosum and cerebellar hemispheres and loss of periventricular white matter. Most individuals with ... As an autosomal dominant disease, children with parents carrying a SON mutation have a 50% risk of inheriting the mutation. ... Lu, Xinyi; Ng, Huck-Hui; Bubulya, Paula A. (2014-04-30). "The role of SON in splicing, development, and disease". Wiley ...
The secondary neuronal axons continue to ascend ipsilaterally and then pass into the cerebellum via the inferior cerebellar ... Spinal cord injury can also be non-traumatic and caused by disease (transverse myelitis, polio, spina bifida, Friedreich's ... The secondary axons pass into the cerebellum via the inferior cerebellar peduncle where again, these axons synapse on ... This pathway initially follows the dorsal spino-cerebellar pathway. It is arranged as follows: proprioceptive receptors of ...
Pfab R, Haberl B, Kleber J, Zilker T (2008). "Cerebellar effects after consumption of edible morels (Morchella conica, ... elms attacked by Dutch elm disease." The species has been named state mushroom of Minnesota, and was the first state mushroom ...
A prion disease called kuru has been traced to this. Brain-computer interface Central nervous system disease List of ... Some parts, such as the cerebral cortex and the cerebellar cortex, consist of layers that are folded or convoluted to fit ... The most important that are covered in the human brain article are brain disease and the effects of brain damage. The shape and ... All these things we endure from the brain, when it is not healthy... On the Sacred Disease, attributed to Hippocrates The Roman ...
He also worked to combat the spread of HIV, advocating education about the disease in schools and workplaces, and early and ... and posterior inferior cerebellar arteries for vertebrobasilar insufficiency", Journal of Neurosurgery, 72 (4): 554-558, doi: ... non-communicable diseases and climate change. Balaji was diagnosed with colorectal cancer and underwent surgical removal of a ... where he learned about the devastating effects of Minamata disease, a neurological syndrome caused by severe mercury poisoning ...
Since demyelinating diseases are a focus of the lab, Klein made a discovery in 2014, that multiple sclerosis (MS) ... she reported that the chemokine CXC12 and its receptor CXCR4 are important in cerebellar granule cell proliferation and ... After Klein arrived at WUSM, she founded the Center for Neuroimmunology and Neuroinfectious Diseases and now directs the center ... Klein's work has continually shown that immune signalling in the brain contributes to brain disease pathogenesis and cognitive ...
... variant Creutzfeldt-Jakob disease (vCJD). This is a separate disease from 'classical' Creutzfeldt-Jakob disease, which is not ... "Ataxias and Cerebellar or Spinocerebellar Degeneration Information Page: National Institute of Neurological Disorders and ... The pathogenesis of BSE is not well understood or documented like other diseases of this nature. Even though BSE is a disease ... "Variant Creutzfeldt-Jakob Disease, Current Data (October 2009)". The National Creutzfeldt-Jakob Disease Surveillance Unit ( ...
Without treatment as many as half the patients can die from the disease. Pertussis is a highly contagious disease that is ... cerebellar ataxia) bacterial infections of the skin and soft tissues in children including Group A streptococcal infections ... Poliomyelitis, known as the disease Polio, is a highly infectious disease caused by a virus that lives in the throat and ... "Meningococcal Disease". CDC. CDC. Retrieved 11 April 2014. "Meningococcal Disease Causes and Spread to Others". CDC. CDC. ...
"Cerebellar Ataxia Rehabilitation Trial in Degenerative Cerebellar Diseases". Neurorehabilitation and Neural Repair. 26 (5): 515 ... Many SCAs below fall under the category of polyglutamine diseases, which are caused when a disease-associated protein (i.e., ... Both onset of initial symptoms and duration of disease are variable. If the disease is caused by a polyglutamine trinucleotide ... which often can result in an earlier age-of-onset and a more severe disease phenotype for individuals who inherit the disease ...
Fañanas cells (also known as Feathered cells of Fañanas) are glial cells of the cerebellar cortex. They are located in the ... One study found deviations of the expression of Vimentin in patients with Creutzfeldt-Jakob disease (CJD) that could be related ... Petersen, Karl Uwe (Dec 1969). On the fine structure of glia cells in the cerebellar cortex of mammals. Springer-Verlag. pp. ... These variances were also described in cerebellar microglia and Bergmann cells. However, the results of the study did not point ...
"Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic ... included PPPD in its draft list of diagnoses to be included to the next edition of the International Classification of Diseases ...
Prion diseases, also called transmissible spongiform encephalopathies (TSEs), are neurodegenerative diseases of the brain ... Symptoms start with slowly developing dysarthria (difficulty speaking) and cerebellar truncal ataxia (unsteadiness) and then ... GSS is part of a group of diseases called transmissible spongiform encephalopathies. These diseases are caused by prions, which ... GSS is a disease that progresses slowly, lasting roughly 2-10 years, with an average of approximately five years. The disease ...
"Canavan Disease, DNA Analysis - Tests - GTR - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-03-31. "Canavan Disease Information ... Affected toddlers typically develop progressive cerebellar syndrome and mental deterioration, which is followed by vision loss ... "Aspartoacylase Deficiency (Canavan Disease) , The Online Metabolic and Molecular Bases of Inherited Disease , OMMBID , McGraw- ... Lienhard U, Sass J (2011-01-01). "Canavan Disease: A Neurometabolic Disease Caused By Aspartoacylase Deficiency". Journal of ...
In comparison, the cerebellar granule cell axon is characterized by a single T-shaped branch node from which two parallel ... Dying back of an axon can also take place in many neurodegenerative diseases, particularly when axonal transport is impaired, ... Matalon R, Michals-Matalon K, Surendran S, Tyring SK (2006). "Canavan disease: studies on the knockout mouse". N- ... Hellier, Jennifer L. (16 December 2014). The Brain, the Nervous System, and Their Diseases [3 volumes]. ABC-CLIO. ISBN ...
... and one of its feeding vessels An anterior view of major cerebral and cerebellar arteries. Circle of Willis Circle of Willis ... Correlation with cerebral collaterals in internal carotid artery occlusive disease". Journal of Neurology. 253 (10): 1285-1291 ...
... may indicate the presence of cerebellar disease. Therefore, an awareness of the phenomenon can assist in the diagnoses of both ... The phenomenon will be present in limbs unaffected by disease or illness, and strongly exaggerated in limbs exhibiting signs of ... "Cerebellar Exam , Stanford Medicine 25 , Stanford Medicine". stanfordmedicine25.stanford.edu. Retrieved 2017-01-08. Koehler, ...
... that dose adjustment of bilastine is not necessary in elderly patients or in chronic liver disease or chronic kidney disease. ... Bilastine binds to guinea-pig cerebellar histamine H1-receptors (Ki=44 nM) and to human recombinant histamine H1-receptors (Ki= ... parallel-group involving male and female patients over 12 year of age with symptomatic disease at the beginning of the study. ...
Worth, P. F.; Giunti, P.; Gardner-Thorpe, C.; Dixon, P. H.; Davis, M. B.; Wood, N. W. (1999). "Autosomal Dominant Cerebellar ... Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ...
Diseases commonly associated with old age include Multiple system atrophy Parkinson's disease Alzheimer's disease Stroke. ... cerebellar vermis, cerebellar hemispheres, and the hippocampus. However, one review found that the amygdala and ventromedial ... Treatment of an age related neurological disease varies from disease to disease. Modifiable risk factors for dementia include ... Grazina R, Massano J (2013). "Physical exercise and Parkinson's disease: influence on symptoms, disease course and prevention ...
Alcohol inhibits sodium-potassium pumps in the cerebellum and this is likely how it corrupts cerebellar computation and body co ... Cederbaum AI (November 2012). "Alcohol metabolism". Clinics in Liver Disease. 16 (4): 667-685. doi:10.1016/j.cld.2012.08.002. ... Mitoma H, Manto M, Shaikh AG (August 2021). "Mechanisms of Ethanol-Induced Cerebellar Ataxia: Underpinnings of Neuronal Death ... mild to moderately bronchoconstriction exacerbations of their asthmatic disease. These allergic reaction-like symptoms, which ...
Friedreich's ataxia Ménière's disease Romberg's test is not a test of cerebellar function, as it is commonly misconstrued. ... Patients with severe cerebellar ataxia will generally be unable to balance even with their eyes open; therefore, the test ... If a patient is ataxic and Romberg's test is not positive, it suggests that ataxia is cerebellar in nature, that is, depending ... on localized cerebellar dysfunction instead. It is used as an indicator for possible alcohol or drug impaired driving and ...
The disease remains fatal, making euthanasia an invariable necessity. Barber RM, Schatzberg SJ, Corneveaux JJ, Allen AN, Porter ... After a short amount of time vestibulo-cerebellar symptoms will rapidly progress, leaving the animal in a state of depressed ... The pathogen that triggers the disease and contributes to its development has not yet been identified. It is presumed to have a ... It was originally identified and recorded in the 1960s in pure breed pugs, with which this disease is nowadays mostly ...
If an MRI is obtained; cerebellar hypoplasia is a common finding.[citation needed] Ocular abnormalities of CDG-Ia include: ... Common manifestations include ataxia; seizures; retinopathy; liver disease; coagulopathies; failure to thrive (FTT); dysmorphic ... Their main features were psychomotor retardation, cerebral and cerebellar atrophy and fluctuating hormone levels (e.g.prolactin ... Archives of Disease in Childhood. 71 (2): 123-7. doi:10.1136/adc.71.2.123. PMC 1029941. PMID 7944531. Haeuptle MA, Hennet T ( ...
He died on July 22 of 1948 in Paris, France.[citation needed] There have been few cases of this disease documented in detail ... Symptoms include ipsilateral (same side) cerebellar ataxia, sensory deficits of the face, and Horner's syndrome, along with ... Similar to Babinski-Nageotte's syndrome, Reinhold syndrome is also a rare disease. But as conducted through a study of 2 ... Evaluation of the cranial MRI screening of the patient with the misdoubt of cerebrovascular disease showed results that were ...
... a lack of coordinated muscle movement caused by cerebellar lesions characteristic of multiple sclerosis. The disease often ... This disease affects the proximal muscles of the head, shoulders, and neck. Tremors of this disease occur at frequencies of 2-4 ... The most common site for cerebellar lesions that lead to intention tremors has been reported to be the superior cerebellar ... Wilson's disease, Creutzfeldt-Jakob disease, Guillain-Barré syndrome and fragile X syndrome, as well as brain tumors, low blood ...
Neuropsychiatric Disease and Treatment. 15: 1873-1885. doi:10.2147/NDT.S120514. ISSN 1176-6328. PMC 6626900. PMID 31371960. ... indicating that the deficit does not likely stem from cerebellar damage. Impaired verbal executive functioning has also been ...
There are currently no human or mouse genes associated with this disease in the MGI database. Synonyms: Hemangioblastoma of ... Disease Ontology Browser cerebellar angioblastoma (DOID:6500) Alliance: disease page Synonyms: Hemangioblastoma of Cerebellum ...
Recognition of the cerebellar pattern of disease can aid in the prompt and correct diagnosis and lead to appropriate treatment ... Clinical manifestations of cerebellar disease include ataxia and tremor, as well as nystagmus, dysarthria, and cognitive ... Clinical manifestations of cerebellar disease Vijayakumar Javalkar 1 , Misbba Khan 1 , Debra E Davis 2 ... Cerebellar diseases. Kornegay JN. Kornegay JN. Probl Vet Med. 1991 Sep;3(3):409-16. Probl Vet Med. 1991. PMID: 1802262 Review. ...
Find symptoms and other information about Cerebellar degeneration. ... About Cerebellar degeneration. Many rare diseases have limited information. Currently GARD aims to provide the following ... The National Library of Medicines Unified Medical Language System (UMLS) is used to classify and organize diseases and disease ... Cerebellar degeneration refers to the deterioration of neurons (nerve cells) in the cerebellum (the area of the brain that ...
Cerebellar Diseases * Subject Areas on Research. * Alternating hemiplegia of childhood. * Atypical imaging findings in a near- ... Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice. * Cerebellar hemorrhage after spinal surgery: report of two ... Limited regional cerebellar dysfunction induces focal dystonia in mice. * Minimally Invasive Surgery for Spontaneous Cerebellar ... Ocular reactions in man from deep cerebellar stimulation and lesions. * Perioperative Assessment of Cerebellar Masses and the ...
... is a lysosomal disease characterized by progressive cerebellar ataxia. In NPC1, a defect in cholesterol transport leads to ... span,,b,:,/b, Niemann-Pick disease, type C1 (NPC1) ... Niemann-Pick disease, type C1 (NPC1) is a lysosomal disease ... Identification of Novel Pathways Associated with Patterned Cerebellar Purkinje Neuron Degeneration in Niemann-Pick Disease, ... Identification of Novel Pathways Associated with Patterned Cerebellar Purkinje Neuron Degeneration in Niemann-Pick Disease, ...
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Start Over You searched for: Subjects Cerebellar Diseases -- pathology ✖Remove constraint Subjects: Cerebellar Diseases -- ...
Cardinal manifestations of cerebellar dysfunction include dysmetria, gait ataxia, and muscle hypotonia. ... Diseases that affect the structure or function of the cerebellum. ... Diseases Ligands Tools. About. Tutorials lightbulb. Search for targets (e.g., ITK) or diseases (e.g., asthma). ... Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include ...
Cardinal manifestations of cerebellar dysfunction include dysmetria, gait ataxia, and muscle hypotonia. ... Diseases that affect the structure or function of the cerebellum. ... Diseases Ligands Tools. About. Tutorials lightbulb. Search for targets (e.g., ITK) or diseases (e.g., asthma). ... Counts of Target Development Levels for diseases known to be associated with this disease. If the disease has a valid DOID, ...
Cerebellar disorders are problems with the cerebellum, an area of the brain that controls coordination and balance. Ataxias is ... Spinocerebellar Ataxias Including Machado-Joseph Disease (National Institute of Neurological Disorders and Stroke) ... Acute cerebellar ataxia (Medical Encyclopedia) Also in Spanish * Multiple system atrophy - cerebellar subtype (Medical ... Cerebellar Hypoplasia (National Institute of Neurological Disorders and Stroke) * Dandy-Walker Syndrome (National Institute of ...
Diseases that cause cerebellar degeneration also can involve the spinal cord and other areas of the brain. ... Cerebellar degeneration is a process in which neurons (nerve cells) in the cerebellum-the area of the brain that controls ... Neurological diseases that feature cerebellar degeneration include:. *Stroke, caused by a blood vessel that is either blocked ... Acquired diseases that can cause cerebellar degeneration include:. *Chronic alcohol abuse that leads to temporary or permanent ...
Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease. Cerebellar morphometric and spectroscopic ... We found decreased cerebellar white and grey matter and enlargement of the fourth ventricle in both MJD mice and human patients ... Machado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is the most common form of dominant SCA worldwide. ... Machado-Joseph disease (MJD); Magnetic resonance imaging (MRI); Motor performance; Proton magnetic resonance spectroscopy (1H- ...
Patterns of Cerebellar Gray Matter Atrophy Across Alzheimers Disease Progression Toniolo S., Serra L., Olivito G., Marra C., ...
Cerebellar Circuit Dysfunction in Complex Motor Diseases. 1:00 p.m. - 2:00 p.m.. ...
Coeliac disease patients do not produce antibodies to a common cerebellar epitope ... Coeliac disease patients do not produce antibodies to a common cerebellar epitope. You are here *UTAS Home ... Coeliac disease patients do not produce antibodies to a common cerebellar epitope, Cerebellum & Ataxias, 1 Article 18. ISSN ... Mouse and human cerebellar and cerebral cortex extracts were analysed by Western blot probed with CD and control sera. ...
Establishment and characterization of human pluripotent stem cells-derived brain organoids to model cerebellar diseases *João ... firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinsons disease ... bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in Alzheimers disease model * ... pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimers disease ...
TIME TO ACT - IMPROVING RARE DISEASE DIAGNOSIS AND SOLVING THE UNSOLVED RARE DISEASE THROUGH COLLABORATION IN EUROPE. May 11, ... Patient information - Cerebellar Ataxia & HSPs - Adult. Please note that this section includes useful information from a ... Italy Two days entirely dedicated to the ultra-rare disease …read more » ...
Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease.. Jay Jagannathan, Russell R ... CONCLUSIONS: Symptoms and signs caused by cerebellar hemangioblastomas in VHL disease are associated with edema and peritumoral ... OBJECT: Despite the frequency of cerebellar hemangioblastomas in von Hippel-Lindau (VHL) disease, their optimum contemporary ... To examine modern management and outcomes of cerebellar hemangioblastomas in VHL disease, the authors reviewed findings in ...
Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies [1]. / Gordon, C. R.; Zivotofsky, A. Z.; Siman ... Gordon, C. R., Zivotofsky, A. Z., Siman-Tov, T., & Gadoth, N. (2007). Stiff person syndrome with cerebellar disease and high- ... Gordon CR, Zivotofsky AZ, Siman-Tov T, Gadoth N. Stiff person syndrome with cerebellar disease and high-titer anti-GAD ... Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies [1]. In: Neurology. 2007 ; Vol. 68, No. 14. pp ...
SCA and head ET subjects (severe and mild cerebellar damage, respectively) were significantly worse at interception than the ... Predictive motor timing performance dissociates between early diseases of the cerebellum and Parkinsons disease Cerebellum. ... Specifically, we investigated four different groups: (1) patients with early Parkinsons disease (PD); (2) patients with ...
Other cerebellar ataxia. ,12. 334.3. 18 (1). Cerebellar ataxia in diseases classified elsewhere. ,12. 334.4. 0 (0). ... Other extrapyramidal disease and abnormal movement disorders. ,12. 333. 0 (0). Other degenerative diseases of the basal ganglia ... Human Prion Disease and Relative Risk Associated with Chronic Wasting Disease W. John Pape†, Jeri Forster*, C. Alan Anderson ... Human Prion Disease and Relative Risk Associated with Chronic Wasting Disease. ...
Consensus paper: radiological biomarkers of cerebellar diseases. Cerebellum. 2015 Apr. 14 (2):175-96. [QxMD MEDLINE Link]. ... 21] and the International Classification of Diseases, 11th Revision (ICD-11) [90] list different criteria for autism spectrum ... 19] ; the International Classification of Diseases, Ninth Revision, Clinical Modification, Fourth Edition (ICD-9-CM) [20] ; the ... Heterogeneous cerebellar anomalies were observed in three of the four girls with frontal asymmetries. These studies suggest ...
Provided by the Centers for Disease Control and Prevention (CDC). ... Delayed cerebellar disease and death after accidental exposure ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ...
Double-blind crossover study with levorotatory form of hydroxytryptophan in patients with degenerative cerebellar diseases. ... Anderson, L. T., Herrmann, L., and Dancis, J. The effect of L-5-hydroxytryptophan on self-mutilatin in Lesch-Nyhan disease: a ... Trouillas, P., Garde, A., Robert, J. M., Renaud, B., Adeleine, P., Bard, J., and Brudon, F. [Regression of the cerebellar ... Bastard, J., Truelle, J. L., and Emile, J. [Effectiveness of 5 hydroxy-tryptophan in Parkinsons disease]. Nouv Presse Med 9-11 ...
Opsoclonic cerebellar disease. A paraneoplastic syndrome sensitive to chlormethiazole].. Lago A; Burguera JA; Vilchez JJ; ... Acute cerebellar ataxia, acute cerebellitis, and opsoclonus-myoclonus syndrome.. Desai J; Mitchell WG. J Child Neurol; 2012 Nov ... Paraneoplastic Cerebellar Degeneration with Lambert-Eaton Myasthenic Syndrome: A Report of an Effectively Treated Case and ... A boy with acute cerebellar ataxia without opsoclonus caused by neuroblastoma].. Blokker RS; Smit LM; van den Bos C; Overberg ...
Cerebellar Diseases/genetics*; Cilia/genetics*; Ciliary Motility Disorders/genetics*; Eye Diseases/genetics*; Female; Humans; ... and common diseases to help prevent disease and improve human health. ... Kidney Diseases/genetics*; Male; Molecular Sequence Data; Pedigree; Proteins/genetics*; Proteins/metabolism*; Rats; Syndrome ...
Laureno R. Nutritional cerebellar degeneration, with comments on its relationship to Wernicke disease and alcoholism. Handb ... Centers for Disease Control and Prevention (CDC). Alcohol and Public Health: Alcohol-Related Disease Impact (ARDI). Annual ... Alcohol-associated liver disease (ALD) plays a major and growing role in alcohol-related morbidity and mortality in the U.S. ... Liver disease: Because 90% of absorbed alcohol is metabolized in the liver, this organ is extensively exposed not only to ...
... associations between celiac disease and other medical conditions, according to a large database study that suggests patients ... Cerebellar ataxia. 0.1. 0.0. 4.1. Autism. 4.0. 0.2. 19.9. Colitis. 25.9. 4.2. 8.4. ... Table 1. Prevalence of Diagnoses in People With and Without Celiac Disease (P , .0001 for All) Diagnosis. With Celiac Disease ... Crohns disease, and ulcerative colitis. "Every autoimmune disease we looked at is associated with celiac disease, other than ...
  • Clinical manifestations of cerebellar disease include ataxia and tremor, as well as nystagmus, dysarthria, and cognitive dysfunction. (nih.gov)
  • Niemann-Pick disease, type C1 (NPC1) is a lysosomal disease characterized by progressive cerebellar ataxia. (nih.gov)
  • Cardinal manifestations of cerebellar dysfunction include dysmetria, gait ataxia, and muscle hypotonia. (nih.gov)
  • has_symptom ataxia, has_symptom dysarthria, and has_symptom cerebellar cognitive affective syndrome. (nih.gov)
  • Machado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is the most common form of dominant SCA worldwide. (bvsalud.org)
  • Our aim was to determine whether there is molecular mimicry between cerebellar Purkinje cell antigens and gluten in subjects selected for recent diagnosis of CD rather than for ataxia. (edu.au)
  • 2. Marked improvement in opsoclonus and cerebellar ataxia after the surgical removal of a squamous cell carcinoma of the thymus: a case report. (nih.gov)
  • 8. Late detection of neuroblastoma in a patient with prolonged cerebellar ataxia without opsoclonus. (nih.gov)
  • 12. [A boy with acute cerebellar ataxia without opsoclonus caused by neuroblastoma]. (nih.gov)
  • 15. Acute cerebellar ataxia, acute cerebellitis, and opsoclonus-myoclonus syndrome. (nih.gov)
  • Diseases associated with ZFP64 include Autosomal Recessive Congenital Cerebellar Ataxia. (antibodies-online.com)
  • Cerebellar degeneration refers to the deterioration of neurons (nerve cells) in the cerebellum (the area of the brain that controls muscle coordination and balance). (nih.gov)
  • Diseases that affect the structure or function of the cerebellum. (nih.gov)
  • Cerebellar degeneration is a process in which neurons (nerve cells) in the cerebellum-the area of the brain that controls coordination and balance-deteriorate and die. (nih.gov)
  • Diseases that are specific to the brain, as well as diseases that occur in other parts of the body, can cause neurons to die in the cerebellum. (nih.gov)
  • Western blot analysis of cerebellar and cerebral cortex extracts probed with CD sera did not demonstrate any specific immunoreactivity unique to the cerebellum. (edu.au)
  • Cerebellar hemangioblastomas are preferentially distributed in the posterior half of the cerebellum, as they are in the brainstem and spinal cord. (qxmd.com)
  • Conditions that cause Cerebellar degeneration may also affect other areas of the central nervous system, such as the spinal cord, the cerebral cortex (the thin layer of cells covering the brain), and the brain stem. (nih.gov)
  • Cerebellar degeneration can be caused by a variety of factors including inherited gene changes , chronic alcohol abuse, and paraneoplastic disorders. (nih.gov)
  • When Do Symptoms of Cerebellar degeneration Begin? (nih.gov)
  • What is cerebellar degeneration? (nih.gov)
  • Diseases that cause cerebellar degeneration also can involve the spinal cord and other areas of the brain, including the medulla oblongata (which is involved in cardiac and respiratory systems), cerebral cortex (involved with thought consciousness, language, emotion, and other processes), and the brain stem. (nih.gov)
  • Cerebellar degeneration may be the result of inherited genetic mutations that alter the normal production of specific proteins that are necessary for the survival of neurons. (nih.gov)
  • There is no cure for hereditary forms of cerebellar degeneration. (nih.gov)
  • Treatment is usually supportive and is based on the person's symptoms or on disorders that may contribute to the cerebellar degeneration. (nih.gov)
  • How can I or my loved one help improve care for people with cerebellar degeneration? (nih.gov)
  • Consider participating in a clinical trial so clinicians and scientists can learn more about cerebellar degeneration. (nih.gov)
  • Learn about clinical trials currently looking for people with cerebellar degeneration at Clinicaltrials.gov , a database of current and past clinical studies and research results. (nih.gov)
  • Where can I find more information about cerebellar degeneration? (nih.gov)
  • 4. Anti-Ri-associated paraneoplastic cerebellar degeneration without opsoclonus in a patient with a neuroendocrine carcinoma of the stomach. (nih.gov)
  • 20. [Paraneoplastic Cerebellar Degeneration with Lambert-Eaton Myasthenic Syndrome: A Report of an Effectively Treated Case and Systematic Review of Japanese Cases]. (nih.gov)
  • 3. Opsoclonus in a patient with cerebellar dysfunction. (nih.gov)
  • Possibilities include cerebellar and brainstem symptoms (e.g. cranial nerve dysfunction, other than vestibulocochlear), or hydrocephalus due to effacement of the fourth ventricle. (radiopaedia.org)
  • Treatment of cerebellar disorders depends on the cause. (medlineplus.gov)
  • The investigators found a significant association between celiac disease and 13 other autoimmune disorders, such as type 1 diabetes, Crohn's disease, and ulcerative colitis. (medscape.com)
  • If the disease has a valid DOID, targets known to be associated with all child diseases are aggregated. (nih.gov)
  • Most common among these is cerebellar disease, which causes loss of motor coordination, swaying, strange gait, facial ticks and sensitivity to light. (vetinfo.com)
  • High titre αGAb sera from 11 newly-diagnosed CD patients and normal sera from 10 healthy controls were used to detect cross-reacting antibodies to cerebellar and cerebral cortex antigens in mouse, monkey and human tissue. (edu.au)
  • Mouse and human cerebellar and cerebral cortex extracts were analysed by Western blot probed with CD and control sera. (edu.au)
  • Cerebellar infarction in the territory of the medial branch of the superior cerebellar artery. (nih.gov)
  • Midbrain area (Ams), pons area (Apn), middle cerebellar peduncle (MCP) and superior cerebellar peduncle (SCP) were measured using MRI. (scielo.br)
  • This study evaluates the diagnostic value of morphometric magnetic resonance imaging (MRI) in the differential diagnosis among Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). (scielo.br)
  • Symptoms and signs caused by cerebellar hemangioblastomas in VHL disease are associated with edema and peritumoral cyst formation/propagation and are treated safely and effectively with resection. (qxmd.com)
  • If you have a patient who is autistic and they have all these unusual symptoms, you might want to screen them for celiac disease," he said here at the World Congress of Gastroenterology 2017. (medscape.com)
  • It is known that there are unusual symptoms of celiac disease, which include anything outside the classic symptoms of malabsorption, steatorrhea, malnutrition, abdominal pain, and cramping after eating, "but this is putting numbers to it," said Dr Karb. (medscape.com)
  • Parkinson's disease (PD) is a disabling neurodegenerative disease whose manifestations span motor, sensorimotor, and sensory domains. (mdpi.com)
  • Consecutive patients with VHL disease who underwent surgery for cerebellar hemangioblastoma(s) at the National Institutes of Health were included. (qxmd.com)
  • Cerebellar motor syndrome from children to the elderly. (nih.gov)
  • The purpose of this paper is to illustrate the brain stem and cerebellar imaging findings in Joubert syndrome. (nih.gov)
  • ORLANDO - Celiac disease is associated with a wide range of medical conditions, including liver disease, glossitis, pancreatitis, Down syndrome, and autism, according to a database study of more than 35 million people. (medscape.com)
  • Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease. (bvsalud.org)
  • Description from Mondo Disease Ontology. (nih.gov)
  • Recognition of the cerebellar pattern of disease can aid in the prompt and correct diagnosis and lead to appropriate treatment and rehabilitation to minimize disability. (nih.gov)
  • Immunofluorescence microscopy was used on mouse and monkey cerebellar sections immunostained with CD and control sera to detect cross-reacting IgG antibodies. (edu.au)
  • Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease. (qxmd.com)
  • Alcohol-associated liver disease (ALD) plays a major and growing role in alcohol-related morbidity and mortality in the U.S. (nih.gov)
  • Drinking beyond U.S. Dietary Guidelines levels can cause liver disease, including steatosis (accumulation of fat), steatohepatitis (inflammation), fibrosis and cirrhosis (scarring), hepatocellular carcinoma, and alcohol-associated hepatitis. (nih.gov)
  • SCA and head ET subjects (severe and mild cerebellar damage, respectively) were significantly worse at interception than the other two groups. (nih.gov)
  • To examine modern management and outcomes of cerebellar hemangioblastomas in VHL disease, the authors reviewed findings in patients with this disease who underwent resection of cerebellar hemangioblastomas. (qxmd.com)
  • Every autoimmune disease we looked at is associated with celiac disease, other than primary biliary cholangitis. (medscape.com)
  • Use ClincalTrials.gov button below to search for studies by disease, terms, or country. (nih.gov)
  • Overall, the age-adjusted prevalence of celiac disease was 0.22%, which is lower than the 1% to 2% range previously estimated. (medscape.com)
  • Editor's Note: This story has been corrected to clarify the prevalence of autism among people with and without celiac disease. (medscape.com)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • Clinical trials determine if a new test or treatment for a disease is effective and safe by comparing groups receiving different tests/treatments. (nih.gov)
  • Participating in research helps researchers ultimately uncover better ways to treat, prevent, diagnose, and understand human diseases. (nih.gov)
  • Clinical research uses human volunteers to help researchers learn more about a disorder and perhaps find better ways to safely detect, treat, or prevent disease. (nih.gov)
  • We found decreased cerebellar white and grey matter and enlargement of the fourth ventricle in both MJD mice and human patients as compared to controls. (bvsalud.org)
  • NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
  • Despite the frequency of cerebellar hemangioblastomas in von Hippel-Lindau (VHL) disease, their optimum contemporary management has not been defined, and is made complex because of the multiple, progressive, and protean nature of the tumors found in patients with this disorder. (qxmd.com)
  • Participants with a disease may participate to help others, but also to possibly receive the newest treatment and additional care from clinical study staff. (nih.gov)
  • They build public awareness of the disease and are a driving force behind research to improve patients' lives. (nih.gov)
  • Eighty consecutive patients (44 female and 36 male patients) underwent 126 operations for removal of 164 cerebellar hemangioblastomas (age at surgery 37.8+/-10.3 years, follow-up duration 96.0+/-60.3 months). (qxmd.com)
  • How to diagnose endocrine disease in obese patients? (endocrine-abstracts.org)
  • White matter hyperintensities associated with small vessel disease impair social cognition beside attention and memory. (mpg.de)
  • CD patient sera with high titre αGAb do not detect a common Purkinje cell or cerebellar-specific epitope. (edu.au)