Neutral Ceramidase: A ceramidase subtype that is active at neutral pH. It is found at high levels within the SMALL INTESTINE and in the BRAIN.Ceramidases: Amidohydrolases that are specific for the cleavage of the N-acyl linkage of CERAMIDES. Ceramidases are classified as acidic, neutral or basic according to the optimal pH with which they function.Acid Ceramidase: A ceramidase subtype that is active at acid pH. It plays an important role in sphingolipid degradation by catalyzing the lysosomal hydrolysis of ceramide to sphingosine and free fatty acid. Inherited deficiency of acid ceramidase activity results in FARBER LIPOGRANULOMATOSIS.Alkaline Ceramidase: A ceramidase subtype that is active at alkaline pH. It is found at high levels within the SMALL INTESTINE.AmidohydrolasesGalactosylgalactosylglucosylceramidase: An enzyme that catalyzes the hydrolysis of a ceramidetrihexoside to a ceramidedihexoside plus galactose.Ceramides: Members of the class of neutral glycosphingolipids. They are the basic units of SPHINGOLIPIDS. They are sphingoids attached via their amino groups to a long chain fatty acyl group. They abnormally accumulate in FABRY DISEASE.Sphingosine: An amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)Sphingomyelin Phosphodiesterase: An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Farber Lipogranulomatosis: A sphingolipidosis subtype that is characterized by the histological appearance of granulomatous deposits in tissues. It results from the accumulation of CERAMIDES in various tissues due to an inherited deficiency of ACID CERAMIDASE.Hematopoiesis: The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).Receptors, Adiponectin: Cell surface receptors for ADIPONECTIN, an antidiabetic hormone secreted by ADIPOCYTES. Adiponectin receptors are membrane proteins with multiple cytoplasmic and extracellular regions. They are about 43 kDa and encoded by at least two genes with different affinities for globular and full-length adiponectin.ArchivesBiological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Adiponectin: A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.Breast Neoplasms: Tumors or cancer of the human BREAST.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Cell Line, Tumor: A cell line derived from cultured tumor cells.Lysophospholipids: Derivatives of PHOSPHATIDIC ACIDS that lack one of its fatty acyl chains due to its hydrolytic removal.Information Services: Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)Consumer Health Information: Information intended for potential users of medical and healthcare services. There is an emphasis on self-care and preventive approaches as well as information for community-wide dissemination and use.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Climatic Processes: Characteristic events occurring in the ATMOSPHERE during the interactions and transformation of various atmospheric components and conditions.Hyperbilirubinemia, Neonatal: Accumulation of BILIRUBIN, a breakdown product of HEME PROTEINS, in the BLOOD during the first weeks of life. This may lead to NEONATAL JAUNDICE. The excess bilirubin may exist in the unconjugated (indirect) or the conjugated (direct) form. The condition may be self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) or pathological with toxic levels of bilirubin.Phototherapy: Treatment of disease by exposure to light, especially by variously concentrated light rays or specific wavelengths.Jaundice, Neonatal: Yellow discoloration of the SKIN; MUCOUS MEMBRANE; and SCLERA in the NEWBORN. It is a sign of NEONATAL HYPERBILIRUBINEMIA. Most cases are transient self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) occurring in the first week of life, but some can be a sign of pathological disorders, particularly LIVER DISEASES.Bilirubin: A bile pigment that is a degradation product of HEME.Hyperbilirubinemia: A condition characterized by an abnormal increase of BILIRUBIN in the blood, which may result in JAUNDICE. Bilirubin, a breakdown product of HEME, is normally excreted in the BILE or further catabolized before excretion in the urine.Ursodeoxycholic Acid: An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.Kernicterus: A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)Exchange Transfusion, Whole Blood: Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.Jaundice: A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.Coronary Vessels: The veins and arteries of the HEART.Vasomotor System: The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.Methylergonovine: A homolog of ERGONOVINE containing one more CH2 group. (Merck Index, 11th ed)Coronary Angiography: Radiography of the vascular system of the heart muscle after injection of a contrast medium.Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.

Increases in ceramide levels in normal human mesangial cells subjected to different cellular stresses result from changes in distinct enzyme activities and can influence cellular responses to other stimuli. (1/125)

Sphingolipids, ceramide in particular, have come to be regarded as having roles in cellular signaling, most recently being associated with stress and the cellular responses to stress. In the present study we first examined the mechanisms involved in the changes in cellular ceramide levels in normal human mesangial cells (NHMC) in the growth, quiescent, and senescent phases as well as those resulting from environmental stimuli. We found that in NHMC total ceramide levels increase in response to cellular stresses as a result of a combination of enzyme activities. Furthermore, different stresses cause different alterations in various enzyme activities, with age and growth influencing acidic enzymes, but cell density affecting neutral, resulting in final ceramide level increases which most likely are associated with distinct pools of ceramide. Secondly, we examined the influence of changes in ceramide levels on apoptosis induced by sphingosine and its methylated derivative N, N-dimethylsphingosine. We found that increases in cellular ceramide levels prohibited the apoptosis and caused a quiescent state in the cells. The data presented here provide additional insight into the roles of ceramide and related enzymes in cellular responses to stress and suggest a possible relevance to in vivo disease states.  (+info)

Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide. (2/125)

A fluorescent analogue of ceramide, C12-NBD-ceramide, was found to be hydrolyzed much faster than 14C-labeled ceramide by alkaline ceramidase from Pseudomonas aeruginosa and neutral ceramidase from mouse liver, while this substrate was relatively resistant to acid ceramidase from plasma of the horseshoe crab. The radioactive substrate was used more preferentially by the acid ceramidase. It should be noted that C6-NBD-ceramide, which is usually used for ceramidase assays, was hardly hydrolyzed by any of the enzymes examined, compared to C12-NBD-ceramide. For the alkaline and neutral enzymes, the Vmax and k (Vmax/Km) with C12-NBD-ceramide were much higher than those with 14C-ceramide. In contrast, for the acid enzyme these parameters with C12-NBD-ceramide were less than half those with the radioisotope-labeled substrate. It is noteworthy that the labeling of ceramide with NBD did not itself reduce the Km of the alkaline enzyme, but did that of the neutral enzyme. It was also found that C12-NBD-ceramide was preferentially hydrolyzed by the alkaline and neutral enzymes, but not the acid one, in several mammalian cell lines. This study clearly shows that the attachment of NBD, but not dansyl, increases the susceptibility of ceramide to alkaline and neutral enzyme, and decreases that to acid enzymes. Thus the use of this substrate provides a specific and sensitive assay for alkaline and neutral ceramidases.  (+info)

Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism. (3/125)

Synthetic ceramides induce apoptotic death of Jurkat and HL60 leukaemia cell lines. By contrast we show here that ceramide induces non-apoptotic killing of malignant cells from patients with B-chronic lymphocytic leukaemia (B-CLL) and of normal B lymphocytes. The protein phosphatase inhibitor okadaic acid readily induces apoptosis of B-CLL cells, indicating that this death pathway is fully functional in these cells. The ability of ceramide to activate the apoptotic protease caspase 3 in HL60 cells but not in B-CLL cells, as well as the lack of correlation of ceramide-mediated killing of different B-CLL isolates with expression of the apoptosis-regulating proteins bcl-2 and bax reinforce the conclusion that ceramide killing of B-CLL cells is by a non-apoptotic mechanism. Fludarabine treatment or gamma-irradiation of B-CLL cells resulted in ceramide elevation and in killing by both apoptotic and non-apoptotic mechanisms, suggesting that a ceramide-triggered non-apoptotic mechanism may play a role in the killing of these cells. Therefore, the results here show that ceramide can induce either apoptotic or non-apoptotic death, depending on the cellular context. The inability of synthetic dihydroceramide to kill B-CLL cells or normal B lymphocytes suggests that non-apoptotic killing by ceramide is via interaction with a specific, but unidentified, cellular target.  (+info)

Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase. (4/125)

Oxidized LDL (oxLDL) have been implicated in diverse biological events leading to the development of atherosclerotic lesions. We previously demonstrated that the proliferation of cultured vascular smooth muscle cells (SMC) induced by oxLDL is preceded by an increase in neutral sphingomyelinase activity, sphingomyelin turnover to ceramide, and stimulation of mitogen-activated protein kinases (Auge, N., Escargueil-Blanc, I., Lajoie-Mazenc, I., Suc, I., Andrieu-Abadie, N., Pieraggi, M. T., Chatelut, M., Thiers, J. C., Jaffrezou, J. P., Laurent, G., Levade, T., Negre-Salvayre, A., and Salvayre, R. (1998) J. Biol. Chem. 273, 12893-12900). Since ceramide can be converted to other bioactive metabolites, such as the well established mitogen sphingosine 1-phosphate (S1P), we investigated whether additional ceramide metabolites are involved in the oxLDL-induced SMC proliferation. We report here that incubation of SMC with oxLDL increased the activities of both acidic and alkaline ceramidases as well as sphingosine kinase, and elevated cellular sphingosine and S1P. Furthermore, the mitogenic effect of oxLDL was inhibited by D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol and N,N-dimethylsphingosine which are inhibitors of ceramidase and sphingosine kinase, respectively. These findings suggest that S1P is a key mediator of the mitogenic effect of oxLDL. In agreement with this conclusion, exogenous addition of sphingosine stimulated the proliferation of cultured SMC, and this effect was abrogated by dimethylsphingosine but not by fumonisin B1, an inhibitor of the acylation of sphingosine to ceramide. Exogenous S1P also promoted SMC proliferation. Altogether, these results strongly suggest that the mitogenic effect of oxLDL in SMC involves the combined activation of sphingomyelinase(s), ceramidase(s), and sphingosine kinase, resulting in the turnover of sphingomyelin to a number of sphingolipid metabolites, of which at least S1P is critical for mitogenesis.  (+info)

Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain. (5/125)

We have purified a membrane bound ceramidase 22,300-fold to apparent homogeneity. The purification scheme included Triton X-100 extraction of membranes followed by Q-Sepharose, blue Sepharose, phenyl-Sepharose, and MonoS column chromatography. The purified enzyme showed an apparent molecular mass of 90 kDa as estimated by SDS-polyacrylamide gel electrophoresis under reducing conditions and 95 kDa by chromatography on Superose 12. Using C(16)-ceramide as substrate, the enzyme showed a broad pH optimum in the neutral to alkaline range. A mixed micelle assay was developed, and using Triton X-100/ceramide mixed micelles, the enzyme exhibited classical Michaelis-Menten kinetics, with a K(m) of 1.29 mol % and a V(max) of 4.4 micromol/min/mg. When dihydroceramide was used as substrate, these values were 3.84 mol % and 1.2 micromol/min/mg, respectively, indicating that the enzyme hydrolyzes ceramides preferentially. The activity of the purified ceramidase did not require cations, and it was inhibited by reducing agents. Phosphatidylcholine and sphingomyelin were without effect on the enzyme activity, whereas phosphatidic acid and phosphatidylserine stimulated the activity 3-fold. Sphingosine acted as a competitive inhibitor with an IC(50) of 5-10 microM. These results indicate that the purified enzyme is a novel ceramidase.  (+info)

Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. (6/125)

Human umbilical vein endothelial cells (HUVEC), like most normal cells, are resistant to tumor necrosis factor-alpha (TNF)-induced apoptosis in spite of TNF activating sphingomyelinase and generating ceramide, a known inducer of apoptosis. Here we report that TNF activates another key enzyme, sphingosine kinase (SphK), in the sphingomyelin metabolic pathway resulting in production of sphingosine-1-phosphate (S1P) and that S1P is a potent antagonist of TNF-mediated apoptosis. The TNF-induced SphK activation is independent of sphingomyelinase and ceramidase activities, suggesting that TNF affects this enzyme directly other than through a mass effect on sphingomyelin degradation. In contrast to normal HUVEC, in a spontaneously transformed endothelial cell line (C11) TNF stimulation failed to activate SphK and induced apoptosis as characterized by morphological and biochemical criteria. Addition of exogenous S1P or increasing endogenous S1P by phorbol ester markedly protected C11 cell line from TNF-induced apoptosis. Conversely, N, N-dimethylsphingosine, an inhibitor of SphK, profoundly sensitized normal HUVEC to killing by TNF. Thus, we demonstrate that the activation of SphK by TNF is an important signaling for protection from the apoptotic effect of TNF in endothelial cells.  (+info)

Molecular cloning, sequencing, and expression of the gene encoding alkaline ceramidase from Pseudomonas aeruginosa. Cloning of a ceramidase homologue from Mycobacterium tuberculosis. (7/125)

We previously reported the purification and characterization of a novel type of alkaline ceramidase from Pseudomonas aeruginosa strain AN17 (Okino, N., Tani, M., Imayama, S., and Ito, M. (1998) J. Biol. Chem. 273, 14368-14373). Here, we report the molecular cloning, sequencing, and expression of the gene encoding the ceramidase of this strain. Specific oligonucleotide primers were synthesized using the peptide sequences of the purified ceramidase obtained by digestion with lysylendopeptidase and used for polymerase chain reaction. DNA fragments thus amplified were used as probes to clone the gene encoding the ceramidase from a genomic library of strain AN17. The open reading frame of 2,010 nucleotides encoded a polypeptide of 670 amino acids including a signal sequence of 24 residues, 64 residues of which matched the amino acid sequence determined for the purified enzyme. The molecular weight of the mature enzyme was estimated to be 70,767 from the deduced amino acid sequence. Expression of the ceramidase gene in Escherichia coli, resulted in production of a soluble enzyme with the identical N-terminal amino acid sequence. Recombinant ceramidase was purified to homogeneity from the lysate of E. coli cells and confirmed to be identical to the Pseudomonas enzyme in its specificity and other enzymatic properties. No significant sequence similarities were found in other known functional proteins including human acid ceramidase. However, we found a sequence homologous to the ceramidase in hypothetical proteins encoded in Mycobacterium tuberculosis, Dictyostelium discoideum, and Arabidopsis thaliana. The homologue of the ceramidase gene was thus cloned from an M. tuberculosis cosmid and expressed in E. coli, and the gene was demonstrated to encode an alkaline ceramidase. This is the first report for the cloning of an alkaline ceramidase.  (+info)

Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized. (8/125)

We report here a novel ceramidase that was purified more than 150, 000-fold from the membrane fraction of mouse liver. The enzyme was a monomeric polypeptide having a molecular mass of 94 kDa and was highly glycosylated with N-glycans. The amino acid sequence of a fragment obtained from the purified enzyme was homologous to those deduced from the genes encoding an alkaline ceramidase of Pseudomonas aeruginosa and a hypotheical protein of the slime mold Dictyostelium discoideum. However, no significant sequence similarities were found in other known functional proteins including acid ceramidases of humans and mice. The enzyme hydrolyzed various N-acylsphingosines but not galactosylceramide, sulfatide, GM1a, or sphingomyelin. The enzyme exhibited the highest activity around pH 7.5 and was thus identified as a type of neutral ceramidase. The apparent K(m) and V(max) values for C12-4-nitrobenzo-2-oxa-1, 3-diazole-ceramide and C16-(14)C-ceramide were 22.3 microM and 29.1 micromol/min/mg and 72.4 microM and 3.6 micromol/min/mg, respectively. This study also clearly demonstrated that the purified 94-kDa ceramidase catalyzed the condensation of fatty acid to sphingosine to generate ceramide, but did not catalyze acyl-CoA-dependent acyl-transfer reaction.  (+info)

*Ceramidase

Presently, 7 human ceramidases encoded by 7 distinct genes have been cloned: acid ceramidase (ASAH1) - cell survival neutral ... Ceramidase at the US National Library of Medicine Medical Subject Headings (MeSH) EC 3.5.1.23 Molecular and Cellular Biology ... Ceramidase (EC 3.5.1.23, acylsphingosine deacylase, glycosphingolipid ceramide deacylase) is an enzyme which cleaves fatty ... UT Southwestern researchers showed that introducing ceramidase in diabetic mice returned their insulin sensitivity to normal. ...

*ASAH2

Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene. GRCh38: Ensembl release 89: ENSG00000188611 - ... 2004). "Neutral ceramidase gene: role in regulating ceramide-induced apoptosis". Gene. 315: 113-22. doi:10.1016/S0378-1119(03) ... 2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... A novel but highly conserved gene family of neutral/alkaline ceramidases". J. Biol. Chem. 275 (15): 11229-34. doi:10.1074/jbc. ...

*ASAH1

2000). "Human acid ceramidase is overexpressed but not mutated in prostate cancer". Genes Chromosomes Cancer. 29 (2): 137-46. ... 2001). "Human acid ceramidase: processing, glycosylation, and lysosomal targeting". J. Biol. Chem. 276 (38): 35352-60. doi: ... The ASAH1 gene encodes in humans the acid ceramidase enzyme. This gene encodes a heterodimeric protein consisting of a ... 2003). "Mutation analysis of the acid ceramidase gene in Japanese patients with Farber disease". J. Inherit. Metab. Dis. 25 (7 ...

*ACER3

Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene. GRCh38: Ensembl ... Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and ... "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. ...

*ASAH2C

Neutral ceramidase C also known as N-acylsphingosine amidohydrolase 2C or non-lysosomal ceramidase C or ASAH2C is a ceramidase ... Hwang YH, Tani M, Nakagawa T, Okino N, Ito M (May 2005). "Subcellular localization of human neutral ceramidase expressed in ... Choi MS, Anderson MA, Zhang Z, Zimonjic DB, Popescu N, Mukherjee AB (October 2003). "Neutral ceramidase gene: role in ... "Identification of a novel amidase motif in neutral ceramidase". The Biochemical Journal. 393 (Pt 3): 687-95. doi:10.1042/ ...

*ASAHL

2005). "Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain". Eur. J. Neurosci. 20 (12): 3489- ... This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript ... "Entrez Gene: ASAHL N-acylsphingosine amidohydrolase (acid ceramidase)-like". Human NAAA genome location and NAAA gene details ... Schulze H, Schepers U, Sandhoff K (2008). "Overexpression and mass spectrometry analysis of mature human acid ceramidase". Biol ...

*ACER2

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene. The ACER2/ ... Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates ... 2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys ...

*Lipid signaling

Sphingosine (Sph) is formed by the action of ceramidase (CDase) enzymes on ceramide in the lysosome. Sph can also be formed in ... The low levels of Sph and their increase in response to stimulation of cells, primarily by activation of ceramidase by growth- ... 2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... Ceramide can also be broken down by enzymes called ceramidases, leading to the formation of sphingosine, Moreover, a phosphate ...

*Carmofur

However, carmofur is a highly potent acid ceramidase (AC) inhibitor. Ceramide influences cancer cell survival, growth and death ... "Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity". Scientific Reports. 3 ( ...

*ACER1

Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene. ACER1 mediates ... "Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal ... Ito M, Okino N, Tani M, Mitsutake S, Mori K (Mar 2002). "[Molecular evolution of neutral ceramidase: signalling molecule and ... "Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates ...

*IRF8

In chronic myelogenous leukemia (CML), IRF8 regulates acid ceramidase to mediate CML apoptosis. IRF8 is highly expressed in ... "IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia". Cancer Res. 71 (8): 2882- ...

*Sphingolipid

Finally, ceramide may be broken down by a ceramidase to form sphingosine. Sphingosine may be phosphorylated to form sphingosine ...

*Farber disease

Normally, the enzyme ceramidase breaks down fatty material in the body's cells. In Farber Disease, the gene responsible for ... Farber disease (also known as Farber's lipogranulomatosis, ceramidase deficiency, "Fibrocytic dysmucopolysaccharidosis," and " ... autosomal recessive lysosomal storage disease marked by a deficiency in the enzyme ceramidase that causes an accumulation of ...

*Sphingosine-1-phosphate

Sphingosine can be released from ceramides, a process catalyzed by the enzyme ceramidase. Phosphorylation of sphingosine is ...

*ENPP7

... neutral ceramidase, and sphingolipid metabolites". Pediatr. Res. 61 (1): 61-6. doi:10.1203/01.pdr.0000250534.92934.c2. PMID ...

*Roivant Sciences

One of its treatments is a version of ceramidase being developed as treatment for Farber disease. Another was licensed from ...

*N-acylethanolamine acid amide hydrolase

NAAA's primary structure is nearly identical to that of acid ceramidase (AC), whose only difference is the substitution of Leu ... It does have 30% homology with acid ceramidase, sharing a significant portion of its amino acid sequence. NAAA was discovered ... While it was discovered within the last decade, its structural similarity to the more familiar acid ceramidase (AC) and ... a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase". The ...

*Fumonisin B1

... de formation via de novo sphinganine and fatty acyl-CoA and via sphingosine produced by the breakdown of ceramide by ceramidase ...

*Juvenile idiopathic arthritis

... genetic lysosomal disorder caused by a deficiency of the enzyme acid ceramidase. It has symptoms similar to JIA including ...

*Ceramide

... can be further hydrolyzed by acid ceramidase to form sphingosine and a free fatty acid, both of which are able to ... Anandamide Ceramidase Inhibitors Chemotherapeutic agents Fas ligand Endotoxin homocysteine heat gamma interferon ionizing ...

*Hugo Moser (scientist)

... and they identified acid ceramidase as the enzyme deficient in Farber's disease. In 1964, Moser returned to the Joseph P. ...

*ASAH2B

Neutral ceramidase B also known as non-lysosomal ceramidase B or N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B ... or ASAH2B is a ceramidase enzyme which in humans is encoded by the ASAH2B gene. ASAH2B shows reduced expression with increasing ...

*List of diseases (C)

Ceramidase deficiency Ceramide trihexosidosis Ceraunophobia Cerebellar agenesis Cerebellar ataxia areflexia pes cavus optic ...

*Daniele Piomelli

Acid Ceramidase inhibitors). Daniele Piomelli is scientific cofounder of Kadmus Pharmaceuticals and Thesan Pharmaceuticals. Di ... "Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity". Science Reports 3:1035. ...

*ASAH

... acid ceramidase), an enzymatic product of ASAH1, gene mutated in Farber disease. ...
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... - Request PDF on ResearchGate | Esteatohepatitis alcohólica y no alcohólica: ¿ quiénes son los pacientes y qué podemos hacer por ellos? | The most common.
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
The adiponectin receptor 1 for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (Tanabe et al. 2015; Yamauchi et al. 2003. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. The 3-d structure revealed ceramidase activity for both ADIPOR1 and ADIPOR2; however, the two structures are substantially different (Vasiliauskaité-Brooks et al. 2017 ...
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)))))Como hacer un Porro Tulipán o Tulip Joint((((( : 1. Pon dos papeles juntos. 2. Enrollados para haceruna especie de cono con él. 3. Ponle t... - Fotolog
Supplementary MaterialsVideo S1. Apical ECM/BM effects modeled as viscous resistances and exterior viscous level of resistance coefficient put on both areas at 8,000?Pa s m?1. Range bar is normally 20?m. Simulation period depicted over the structures. mmc3.mp4 (2.0M) GUID:?63F04E92-06A0-488F-8AD5-FA7674E03304 Video S3. Appropriate Flip Morphology Emerges with Planar Differential Development Prices and an 1187594-09-7 Explicit Description …Read More. ...
Qué fue de Jorge Sanz?,4,¿Y tú qué miras?,1,71,5,(500) Días Juntos,4,(Now and then there´s) A fool such as I,1,@Aleyt1,1,@bgtraducciones,1,@MissMacGuffin,1,#0,3,#DobleoNada,1,#Littlesecretfilm,1,#SemanaWhovian,4,#SeQueSoySeriefiloPorque,1,007,3,007: James Bond de espía a icono,1,10 años,1,10 razones para odiarte,3,100 capítulos,3,10000 KM,9,1001 películas,1,10ª temporada,27,10º episodio,4,10x01,2,10x02,2,10x03,1,10x04,1,10x05,1,10x06,1,10x07,1,10x08,1,10x09,2,10x10,1,10x11,1,10x12,1,10x13,1,10x14,1,10x15,1,10x16,1,10x17,1,10x18,1,10x19,1,10x20,1,10x21,1,10x22,1,10x23,1,11ª Temporada,9,11º episodio,3,11x01,2,11x02,1,11x03,1,11x04,1,11x05,1,11x06,1,11x07,1,11x08,1,11x09,1,11x10,1,12 años de esclavitud,23,12 Valientes,1,120 pulsaciones por minuto,1,120fps,1,12ª temporada,22,12º episodio,3,12x01,1,12x02,1,12x03,1,12x04,1,12x05,1,12x06,1,12x07,1,12x08,2,12x09,2,12x10,1,12x11,2,12x12,2,12x13,2,12x14,2,12x15,2,12x16,2,12x17,2,12x18,2,12x19,2,12x20,2,12x21,2,12x22,2,12x23,2,12x24,1,13 ...
Bueno para quienes quieran contactarme vía e-mail para hacer pedidos, por si se rompe algún enlace, o cualquier otro motivo. ...
¿Buscas algo que hacer en Stockton-On-Tees? Tanto si eres del lugar, recién llegado o estás de paso, tenemos montones de sugerencias y eventos estupendos para que los explores. ¿Listo?
Alguien recibio una respuesta parecida en hacer If its completely as sole provider however in understanding it still allowed while CVS and minimize. As a...
De gusto a uno de sus allegados ofreciéndole esta tarjeta regalo. Usted puede dársela en mano o hacer que se la envíen directamente. See for more details (Instructions in English : voir la versio
De gusto a uno de sus allegados ofreciéndole esta tarjeta regalo. Usted puede dársela en mano o hacer que se la envíen directamente. See for more details (Instructions in English : voir la versio
Bueno para quienes quieran contactarme vía e-mail para hacer pedidos, por si se rompe algún enlace, o cualquier otro motivo. ...
TY - JOUR. T1 - Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities. AU - Sikora, Jakub. AU - Dworski, Shaalee. AU - Jones, E. Ellen. AU - Kamani, Mustafa A.. AU - Micsenyi, Matthew C.. AU - Sawada, Tomo. AU - Le Faouder, Pauline. AU - Bertrand-Michel, Justine. AU - Dupuy, Aude. AU - Dunn, Christopher K.. AU - Xuan, Ingrid Cong Yang. AU - Casas, Josefina. AU - Fabrias, Gemma. AU - Hampson, David R.. AU - Levade, Thierry. AU - Drake, Richard R.. AU - Medin, Jeffrey A.. AU - Walkley, Steven U.. PY - 2017/4/1. Y1 - 2017/4/1. N2 - Farber disease is a rare autosomal recessive disorder caused by acid ceramidase deficiency that usually presents as early-onset progressive visceral and neurologic disease. To understand the neurologic abnormality, we investigated behavioral, biochemical, and cellular abnormalities in the central nervous system of Asah1P361R/P361R mice, which serve as a model of Farber disease. Behaviorally, the mutant mice had reduced ...
Looking for online definition of Alkaline CDase 3 in the Medical Dictionary? Alkaline CDase 3 explanation free. What is Alkaline CDase 3? Meaning of Alkaline CDase 3 medical term. What does Alkaline CDase 3 mean?
123MyMD.com and its services are for informational purposes only and are not a substitute for professional medical or health advice, examination, diagnosis, or treatment. Always seek the advice of your physician or other qualified health professionals before starting any new treatment, making any changes to existing treatment, or altering in any way your current exercise or diet regimen. Do not delay seeking or disregard medical advice based on information on this site. Medical information changes rapidly and while 123MyMD.com and its content providers make every efforts to update the content on the site, some information may be out of date. No health information on 123MyMD.com, including information about herbal therapies and other dietary supplements, is regulated or evaluated by the Food and Drug Administration and therefore the information should not be used to diagnose, treat, cure, or prevent any disease without the supervision of a medical doctor.. ...
Rejoice, those avoiding wheat and gluten! Deva has developed a phytoceramide supplement from sweet potatoes to give you all the amazing anti-aging benefits youve heard about without the irritants found in wheat-based supplements.
¿Buscás algo que hacer en Grapevine? Seas residente, nuevo en la ciudad o simplemente estés de paso, tenemos un montón de sugerencias y eventos. Podés explorar por ubicación, por popularidad, por nuestras mejores selecciones, eventos gratis... lo que te parezca. ¿Listo?
The KRAB-zinc finger proteins (KRAB-ZFPs) represent an extremely large, but poorly understood, family of transcriptional regulators in mammals. (Sera) cells, endogenous KRAB-ZFPs do not. Rather, KRAB-ZFPs and KAP1 relocalise to novel nucleoplasmic foci that we possess termed KRAB- and KAP1-connected (KAKA) foci. HP1s can also concentrate in these foci and there is a close spatial […]. ...
2009/3/6 Marcelo Guzmán ,marcegl91 at gmail.com,: ,, Evitar el top-posting está entre las sugerencias, no entre las reglas. , , De hecho, no. Se obliga al user a no hacer top-posting. Ojo, eh!. Yo estoy de acuerdo con NO hacer top posting..., pero es falso que es una sugerencia, son las reglas de la lista, y como ellas mismas, deben ser respetadas. Marcelo: Acá tenés las reglas y las sugerencias. Te recomiendo que las leas: https://wiki.ubuntu.com/ArgentinaTeam/EtiquetaML Idem para el compañero Hugo Valencia. No seamos más estrictos que la propia etiqueta. Querámosnos. Saludos Moski ...
In some countries, you might find that the Women on Web website is censored. Here you can read about several ways you… Read more » ...
Hoy por fin despues de muchos dias, me puse a hacer tarjetas para mi tienda, la mayoria fueron hechas con colores alucivos a la primavera que ya esta a la vuelta de la esquina, aunque aqui en pa. aun tenemos 2 pies de nieve y esta muy frio pero bueno, llegara cuando menos nos lo esperemos. Por cierto estoy muy emocionada utlizando mi nueva herramienta de calor con la que puedo hacer el relieve de los sellos... me encanta ...
Donde puedo comprar Un estimulante hormonal de iforce nutrition barato ZMA para aumentar la testosterona de forma rápida y hacer crecer los músculos muy sano
Usamos cookies para trabajar de una manera eficaz. Usted declara estar de acuerdo con ello al hacer uso de esta web. Consentimiento para el uso de cookies.. ...
Directo USA entrevista al Senador estatal de Califonia Ben Allen sobre su propuesta de ley para hacer obligar la vacunación en California
Usamos cookies para trabajar de una manera eficaz. Usted declara estar de acuerdo con ello al hacer uso de esta web. Consentimiento para el uso de cookies.. ...
K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K04708 E1.1.1.102; 3-dehydrosphinganine reductase [EC:1.1.1.102] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K12348 ASAH1; acid ceramidase [EC:3.5.1.23] K12349 ASAH2; neutral ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K04711 ACER3; dihydroceramidase [EC:3.5.1.-] K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] K04714 SGMS; shingomyelin synthase [EC:2.7.8.27] K04714 SGMS; shingomyelin synthase [EC:2.7.8.27] ...
Thank you for your interest in spreading the word about Haematologica.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Cuando una persona es adolescente comienza a estar más consciente de lo que piensan otras personas. Parece haber algo "correcto" que ponerse, o decir, o hacer. También parecen estar las cosas que no se deben hacer; cosas que podrían ser vergonzosas, o que lo harán perder puntos con los amigos.. La idea de que las personas puedan estar prestando atención particular a lo que hacen, pone a muchos niños ansiosos; algunos están tan ansiosos que desarrollan algo que se llama trastorno de ansiedad social. Es cuando una persona se preocupa tanto acerca de lo que le parece a otras personas que deja de hacer las cosas que necesita (y desea hacer) por el miedo a avergonzarse a sí mismo.. La mayoría de las personas con el trastorno comienza a notar esta ansiedad cuando están en edades entre 8 y 15 años. Durante un tiempo, los niños usualmente son capaces de ocultarlo. Sus padres y maestros podrían no notar que haya algo malo, especialmente debido a que los niños con frecuencia se sienten ...
Music video by Sethler performing Qué Vas a Hacer. (P) 2013 The copyright in this sound recording is owned by Hugo Martín Cuervo under exclusive licence to EMI Music Spain, S.L.. Watch it on Contactmusic.com.
Visit Healthgrades for information on Dr. Charles Farber, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
La clave para perder peso es hacer cambios peque os todos los d as. Esto ayuda a establecer h bitos saludables y duraderos. Las dietas que prometen ayudarte a perder peso r pido no son saludables y pueden hacer que subas de peso ...
Cremita de disco de brutal death tecnico. Estos yanquis si saben hacer buen ruido cuando se ponen enfermos. Tus oidos seguro que te agradeceran ser penetrados por Lust of Decay. ...
Somos una agencia de Branded Entertainment Marketing con más de 23 años de recorrido en la gestión del talento, eventos y estrategia. Trabajamos campañas con influencers y queremos hacer más ágil el proceso de gestión entre influencer - Thinketers - cliente, con beneficios para todos ...
En algunos casos una actividad extenuante, que demanda mucho tiempo diariamente y que desgasta al cuidador tanto física como mentalmente puede hacer que este se sienta exhausto lo cual conlleva al estrés.
Last reply by Virtu : Tambien existe este otro lugar. Se trata de un refugio para caballos situado en Malaga. Se llama CYD Santamaria. Aqui dejo la web: http://www.asociacioncydsantamaria.es/ Se puede ir como voluntario, hacer microdonativos... more» ...
hola buenos d as tengo 2 tarjetas antiguas del aljazeera sport una de Viaccess y la otra es de irdeto se puede hacer algo con ellas con un programador
Equipo de Asistencia de Servicios Generales (GSA) del Centro de Cáncer de UNM Como paciente nuevo, es muy probable que tenga muchas preguntas acerca de sus cuidados y sobre qué hacer si se presentan ciertas situaciones. A continuación, aparecen algunas de las preguntas más frecuentes. Si tiene preguntas adicionales, no dude en dirigirse a su Asesor …
Una vez descargado el curso o capítulo, ir a la carpeta donde se descargó y hacer clic sobre el archivo para instalarlo en su ordenador. Cuando acabe la instalación aparecerá en el menú Inicio un grupo de programas llamado Curso de ViaFutura. Haga clic en cualquiera de los capítulos para poner en funcionamiento el mismo ...
Como hay tantos análisis de como ha ido el E3, aquí os dejo este vídeo. Lo que puede hacer el aburrimiento y un montón de botellas.
Weve analyzed price, features, and reviews of Acer GPS to find the best values. Also find quick links to the most useful user reviews for all Acer GPS models.
Chromebooks are not exactly known for their high end specifications, which is perhaps why they never really sold like hotcakes either. Well, the Acer...
parasiticidal definition: with the capacity of destroying parasites, specifically effective at expelling or destroying parasitic worms.; related to or for the nature of a parasiticide.; effective at expelling…
An authentic small animal model of Farber disease would greatly facilitate research into disease mechanisms and aid in the development of effective therapies. Unfortunately, a complete knock‐out model of Farber disease resulted in early embryonic lethality (Li et al, 2002) and a reduction of ACDase activity in the ovaries of a conditional knock‐out resulted in oocyte apoptosis (Eliyahu et al, 2012). These data highlight the difficulty in generating mouse models of certain LSDs, in particular the lipid storage disorders. These data also suggest that normal ceramide levels and metabolism are critical for early embryonic development.. Significant progress has been made towards effective therapies for LSDs through the use of recombinant enzyme replacement, bone marrow transplantation (BMT), small molecule drugs and gene therapy. It is likely that Farber disease would be responsive to similar approaches. However, the lack of an authentic animal model of Farber disease has hindered this ...
Conclusions A significant percentage of moderate Farber Disease patients are likely diagnosed as having JIA. Given this finding, it is important to increase awareness of Farber Disease in the pediatric rheumatology community. Differential diagnosis can be made by accounting for the comparatively early onset, progressive symmetric arthritis, presence of subcutaneous nodules at the joints, scalp and/or spine, and an unusual, hoarse cry or voice (due to nodule formation on the larynx) in FD patients. Based on experience with bone marrow transplantation in Farber Disease2, enzyme replacement therapy could resolve or significantly attenuate the arthritis phenotype in patients. Such therapy is currently under development. We propose that Farber Disease can account for specific cases diagnosed as JIA, and that clinically guided genetic screening of the JIA population will reveal patients who can benefit from disease-specific care and treatment.. ...
Teijaro, J.R., Turner, D., Nam, Q., Wherry, E.J., LeFrançois, L. and Farber, D.L. (2011) Cutting Edge: Tissue-retentive lung memory CD4 T cells mediate optimal protective responses to influenza. J. Immunol. 187:5510-14.. Sathaliyawala, T., Kubota, M., Yudanin, N., Turner, D., Camp, P., Thome, J.C., Bickham, K.L., Lerner, H., Goldstein, M., Sykes, M., Kato, T and Farber, D.L. (2013) Distribution and compartmentalization of human circulating and tissue-resident memory T cells. Immunity. 38: 187-197. (Also see preview article in same issue by Neuenhahn and Busch, D.H., "Whole body anatomy of human T cells". Immunity. 38:10-12.). Turner, D.L., Bickham, K.L., Farber, D.L. and Lefrancois, L. (2013) Splenic priming of virus-specific CD8 T cells following influenza infection. J. Virol. 87:4496-506. Turner, D.L., Bickham, K.L., Thome, J.J.T., Kim, C., DOvidio, F., Wherry, E.J. and Farber, D.L. (2014) Lung resident niches for the generation and maintenance of influenza-specific memory T cells. Mucosal ...
When David Hahns daughter was in high school, she had to complete an oral-history project on someone with an extraordinary life story.. For Hahn, one person immediately came to mind: Erich Farber.. "He has a story that you really wont find from anyone else," said Hahn, chair of the Department of Mechanical and Aerospace Engineering at the University of Florida. "He was truly remarkable.". Farber, who became a faculty member in the department in 1954 and eventually served as director of UFs Solar Energy and Energy Conversion Laboratory, passed away on April 9. He was 95.. He was a world-renowned expert, cutting-edge researcher and 36-year professor in solar-energy technologies. In addition, he earned military decorations in World War II and served as a mountain-climbing instructor and Boy Scout leader.. "My dad had the ability to do just about anything," said his son, Webb Farber, "and he did.". Erich Farber was passionate about researching and developing solar-energy technologies at a time ...
Latest News on Dana-farber-cancer-institute-boston. Read breaking stories and opinion articles on Dana Farber Cancer Institute Boston at Firstpost
Empezé a elegir lo que me gustaba, a hacer las cosas que me apetecían y no lo que debería de hacer.. Y es en estos cambios en los que estoy interesado, en que las personas elijan lo que les divierte y les hace vivos.. Era un estudiante normal a pesar de que no entendía mucho el por qué estudiar tantas cosas y tener unos horarios repetitivos y estructuras. Un poco aburrido.. Así que entre esa rebeldia y curiosidad para descubrir otras formas de vivir, me di cuenta que quería dedicar mi vida a hacer lo que me guste.. Y veo que eso crea un mundo mejor para mi y para otras personas, cuando uno elije lo que le funciona, se respeta y así puede respetar las elecciones de los otros, con lo cual se crea más facilidad para el mundo y una realidad más grandiosa.. Y encontrar Access ha sido un regalo immenso para que esto sea posible. Para tener más de mí. Conocer mucho más de mi y abrirme a recibir y crear mucho más en esta vida en este planeta. Agradezco a Access Consciuosness y sus ...
AbeBooks.com: Power Over Pain: Intelligent Fitness for the Amateur and Professional (9781939550125) by Shereen D D Farber; Debra S Knapp and a great selection of similar New, Used and Collectible Books available now at great prices.
Sphingolipids are a family of membrane lipids with important structural roles in the regulation of the fluidity and subdomain structure of the lipid bilayer, es...
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Overview (in German). Der Sphingolipidmetabolismus kann virale Infektionen und Immunantworten auf vielen Ebenen beeinflussen. In unserem Masernvirus (MV)-Infektionsmodell des zentralen Nervensystems (ZNS) beobachteten wir bereits die Folgen der sauren Sphingomyelinase (Asm)-Defizienz in Mäusen, nämlich eine verminderte Widerstandsfähigkeit gegenüber viraler Infektion, und entdeckten, dass sowohl genetische Defizienz, als auch pharmakologische Hemmung der Asm die Aktivität CD4+ Foxp3+ regulatorischer T-Zellen (Treg) erhöht (Hollmann et al., J. Immunol, 2016, 197:3130-3141). Nun wollen wir herausfinden, wie assoziierte Reaktionswege und Enzyme, für die teilweise Inhibitoren schon in klinischem Gebrauch sind, genutzt werden können, um den gegenteiligen Effekt zu erreichen, d.h. die antivirale Immunreaktion zu stärken. Vorläufige Daten weisen darauf hin, dass die MV-Infektion durch Inhibition der sauren Ceramidase (Acd) oder der Sphingosin-Kinase-1 gehemmt wird. In der kommenden ...
نِظَامٌ غِذَائِيّ, يَلْتَزِمُ بِحَمِيَّةٍ غِذَائِيَّةٍ držet dietu, strava diæt, være på slankekur Diät halten, Nahrung διαίτα, κάνω δίαιτα dieta, hacer dieta, hacer régimen laihduttaa, ruokavalio être au régime, régime dijeta, držati dijetu dieta, essere a dieta ダイエットする, 日常の食べ物 식이 요법, 식이 요법을 하다 dieet, lijnen diett, være på diett dieta, zastosować dietę dieta, fazer dieta диета, соблюдать диету banta, diet ควบคุมอาหารเพื่อลดน้ำหนัก, อาหาร rejim, rejim yapmak ăn kiêng, chế độ ăn uống 节食, 饮食 ...
Mientras veía foto en Pinterest, me encontré esta técnica y me encantó. Creo que debo hacer un gran esfuerzo para mejorar mis uñas e intentarlo. ¿Alguna vez has intentado hacer tu mani de esta forma? El usuario de quien hizo esta imagen está abajo, por lo que así pueden seguirla.. I found this browsing through Pinterest and just loved it, so I decided to share it. I think I should do a big effort to get decent nails an then try it. Have you ever tried doing your nails like this? You cana find the username of who created this pin below, so you can follow her.. ...
Con 192 países miembros, INTERPOL es la mayor organización policial internacional del mundo. Nuestra función es permitir que las policías de todo el planeta colaboren para hacer del mundo un lugar más seguro. Nuestra moderna infraestructura de apoyo técnico y operativo contribuye a hacer frente a las crecientes dificultades que comporta la lucha contra la delincuencia en el siglo XXI.. ...
Im a default crier. I happy-cry, stress-cry, romantic-comedy-cry, regular-comedy-cry and, apparently, I even doctor-in-training-cry. Crying is a tough response, especially for someone who wants to take care of sick patients. My default reaction poses challenges for my future career. I had my first taste of this when a patient actor brought me to tears. An actor? Thats ridiculous, you might think. It was all pretend and yet, I broke down. Im ...
mi pmp carga y enciende su luz pero no quiere encender el aparato no enciende por nada que puedo hacer por favor - iRiver PMP-140 Digital Media Player question
El aborto inducido es una de las intervenciones médicas que más se realizan. Hacer que el aborto sea ilegal no reduce el número de aborto. 20 de los 42 millones de abortos realizados cada año no son legal y seguros. La legalización del aborto puede prevenir el sufrimiento y la muerte innecesarios… Read more » ...
Alojarte con una familia en el país anfitrión de tu elección es la mejor forma de conocer la cultura del sitio. Entra dentro de los factores normales del proceso de adaptación, mas tiene que hacer un esfuerzo para integrarse en lo que será desde este momento su nuevo ambiente familiar y social y dejar atrás su país.
Vestilab utiliza COOKIES anónimas para optimizar continuamente su web. Al hacer uso de esta página web, declara usted su conformidad con el uso de cookies. Encontrará más información en la sección de información sobre cookies.. ...
Alojarte con una familia en el país anfitrión de tu elección es la mejor forma de conocer la cultura del sitio. Entra dentro de los factores normales del proceso de adaptación, mas tiene que hacer un esfuerzo para integrarse en lo que será desde este momento su nuevo ambiente familiar y social y dejar atrás su país.
Farber Specialty Vehicles has been awarded U.S. Communities contract for Specialty Vehicles, Equipment and Accessories and any Related Equipment, Supplies and Services.
The Acer Liquid Z6 Plus is an impressive upgrade over the regular Z6 and if it wasnt the mediocre chipset we might have considered it a proper...
Another in the Acer Aspire 11.6 1366x780 product line - but this time things didnt go as smoothly as I would have liked thanks to the wi-fi.
Acer Aspire Switch Alpha 12S (SA5-271) which is considered to be the next model of this series. The name is certainly very long. Isnt it? Most of the ....
Top ⭐ 17 reasons for Acer A7600U-UR12 vs Dell UltraSharp UP3218K: 1. Every pixel has three subpixels: Yes vs Yes 2. Screen size: 27 vs 32 3. Has a HDMI output: No vs Yes
Top ⭐ 24 reasons for Acer A7600U-UR12 vs NEC E201W: 1. Every pixel has three subpixels: Yes vs Yes 2. Screen size: 27 vs 20 3. Has a HDMI output: No vs Yes
Dermatophilus congolensis is a gram positive bacterium which causes a skin disease in a wide range of animals including man. This disease is called dermatophilosis, commonly known as rain rot. Dermatophilosis causes extensive damage within the animal industry, including loss of days at work, reduction in milk yield, and deterioriation of hide and meat quality. This disease requires quick diagnostic tools and sustainable treatment to avoid economic losses. ^ The 1029 bp DNA segment of the alkaline ceramidase gene of D. congolensis was targeted to develop a species-specific PCR to speed up the diagnostic and treatment process to minimize economic losses. The PCR is sensitive, specific and detects as low as 50 × 10-3µg of D. congolensis DNA within 4 hours. This PCR has potential clinical application for rapid diagnosis of dermatophilosis. ^ Caprylic acid is a medium chain fatty acid that contains 8 carbons in its structure. Caprylic acid and its derivatives, namely monocaprylin and sodium caprylate, are
May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.
Rice Phytoceramide is a plant-sourced phytoceramide that helps provide a plumper, smoother appearance to the skin . Ceramides make up 50% of the lipids in the skins epidermis layer. Increased water loss and skin barrier dysfunction has been linked to decreases in the amount of ceramides in the epidermis. It is known that drier skin is more susceptible to develop lines and wrinkles. The ceramides are absorbed through the digestive process and are carried by blood vessels to the outer layer of the epidermis (stratum corneum) where reinforces the skins ability to retain water, thereby providing the skin with a fuller, smoother appearance ...
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Por el periodista Salvador Holguín. Para nadie es un secreto en la República Dominicana y fuera del país que para lograr la reelección del presidente Danilo Medina Sánchez en el 2016, no sólo tuvo que "comerse el tiburón podrido", sino también hacer diabluras que ni los más acérrimos enemigos de la patria y adversarios del PLD nunca pensaron, ni mucho menos imaginaron que podía hacer un hombre como Danilo, que todos lo creíamos serio, decente, leal y transparente, lo que resultó ser todo lo contrario. La conjura reeleccionista de Medina fue ejecutada en tres etapas; la primera la preparó con el gánster brasileño y asesor suyo, Joao Santana, la misma consistió en perseguir e inhabilitar al brazo armador del expresidente Leonel Fernández, el senador y secretario de organización del PLD, Félix Bautista, Danilo Medina mandó a hacerle un expediente judicial que lo asesinara moralmente y lo mantuviera fuera de combate sin capacidad de accionar en su contra ni a favor de Leonel, ...
This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009 ...
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Team ZipCar, a group of cyclers put together for Dana Farber Cancer Institutes annual Pan Mass Challenge, a grueling bike-a-thon raising money for cancer research and treatment.
The sphingolipid metabolites and genes (with the gene abbreviations shown in boxes, or enzyme names where gene names are ambiguous) are given for the condensation of serine and palmitoyl-CoA to form 3-ketosphinganine (3-ketoSa) by serine palmitoyltransferase, which is reduced to sphinganine (Sa), acylated to dihydroceramides, DHCer, by (DH)Cer synthases, and incorporated into more complex DH-sphingolipids (the 1-phosphate, DHCerP, sphingomyelins, DHSM, glucosylceramides, DHGlcCer, galactosylceramides, DHGalCer, lactosylceramides, DHLacCer, and sulfatides, or desaturated to Cer followed by headgroup addition. Also included are a number of the catabolic genes, e.g., sphingomyelinases, SMases, ceramidases, ASAH, sphingosine kinases, for the formation of sphinganine 1-phosphate (Sa1P) and sphingosine 1-phosphate (So1P), and phosphatases for the reverse reaction and the lyase that cleaves sphingoid base 1-phosphates to ethanolamine phosphate (EP), hexadecanal (C16:0al) and hexadecenal (C16:1al ...
Sidney Farber (September 30, 1903 - March 30, 1973) was an American pediatric pathologist. He is regarded as the father of modern chemotherapy, and the Dana-Farber Cancer Institute is named after him. He was born in Buffalo, New York to Jewish parents Simon and Matilda (Goldstein) Farber. He was the third oldest of 14 siblings. He was the younger brother of the noted philosopher and University of Buffalo professor Marvin Farber (1901-1980). Sidney Farber graduated from SUNY Buffalo in 1923. In the mid-1920s, Jewish students were often refused admission to US medical schools, prompting him to go to Europe. As Farber was fluent in German, he undertook his first year of medical school at the Universities of Heidelberg and Freiburg in Germany. Having excelled in Germany, Farber entered Harvard Medical School as a second-year student and graduated in 1927. After graduate training in pathology at Peter Bent Brigham Hospital (the predecessor of Brigham and Womens Hospital) in Boston, Massachusetts, ...
... is a very competent attorney who has been practicing law for 40 years. Mr. Farber is a Personal Injury lawyer specializing primarily in Motor Vehicle Accidents. He is licensed to practice in the state of Pennsylvania, the U.S. District Court, the Eastern District of Pennsylvania, and the Middle District of Pennsylvania.. Stephen graduated from Penn State University with a BA in Mathematics, and spent a year teaching Junior High School Math to save money for Law School. He earned his Juris Doctor from Temple University School of Law. While in Law School, Stephen had the rare opportunity to prosecute cases, as part of his coursework, when he attended a Prosecution Seminar taught by then District Attorney, Arlen Specter.. Mr. Farber joined Master Weinstein Moyer, P.C. in 1994, after spending several years at two prominent Philadelphia area law firms and seven years as a Partner in his own firm. In his earliest years as an attorney, Mr. Farber practiced Criminal Law in addition to ...
AIMS/HYPOTHESIS: An accumulation of ceramides has been implicated in the generation of insulin resistance in skeletal muscle upon an oversupply of fatty acid. Different ceramide species are generated through the actions of ceramide synthases (CerSs), which incorporate specific acyl side chains. We tested whether particular CerS isoforms promoted insulin resistance through the generation of more inhibitory ceramide species, thus representing potential targets for intervention. METHODS: CerS isoforms CerS1, CerS2, CerS4, CerS5 and CerS6 were overexpressed in L6 myotubes using adenovirus, and cells were treated with palmitate and stimulated with insulin. Alternatively, CerS isoforms were knocked down using siRNAs. Sphingolipids were examined by mass spectrometry and tracer incorporation. Phosphorylation of IRS1 and Akt was measured by immunoblotting, while glucose disposal was assessed by measuring GLUT4 translocation and the incorporation of [(14)C]glucose into glycogen. RESULTS: Palmitate treatment
Introduction. In this study, we evaluated the anticancer activity of DM102 [(2R,3Z)-N-(1-hydroxyoctadec-3-en-2-yl)pivalamide], a novel inhibitor of the enzyme acid ceramidase (AC), a key regulator of ceramide metabolism, in combination with C6-ceramide (C6-cer) in human breast cancer cells. Ceramide, a bioactive sphingolipid and potent enhancer of apoptosis, is known to play a role in chemo- and radiation-induced cell death. AC tempers ceramide-induced apoptosis by hydrolysis, producing sphingosine and free fatty acid, thus reducing intracellular ceramide levels and providing substrate for sphingosine kinase, which converts sphingosine to sphingosine 1-phosphate. AC has emerged as a putative anticancer target following reports of upregulation in prostate cancer and in some breast tumors. In the present work, we determined whether the introduction of an AC inhibitor would enhance the apoptosis-inducing effects of C6-cer in breast cancer cells.. Methods. Cultured breast cancer cells were ...
SAE SP.; International spring fuels and lubricants meeting; Statistics, measurement & testing; Toulouse, France, 2004; Jun, 2004, 1-6 -- Warrendale, Penn.; [Great Britain]; Society of Automotive Engineers; c2004 (pages 1-6) -- ...
Based on the http://skincareinfo4u.com/instalyft-rx-review-with-video-does-instalyft-rx-peptide-cream-work/ - how much is instalyft rx - , the product talked about is unquestionably a anti-aging cream thats acknowledged to make use of an "advanced phytoceramide method" that instantly removes facial lines, removes swelling, boosts bovine collagen manufacturing, increases pores and skin elasticity, and decreases your skins pure process of getting older. Really, InstaLyft Rx is stated to minimize signs of getting older by as a lot as ten years ...
Partiendo de un buen briefing y con una alta implicación del product manager es mucho más probable hacer una buena campaña o proponer una buena acción.
Si queréis podéis agregarle unas patatas al horno, hervidas o al microondas para completar vuestro menú.. Si os interesa os enseñaré la receta de como hacer patatas "fritas" fit, igual de sabrosas y crujientes! Decírmelo en los comentarios!. Soñar, vivir y ser muuy felices. - - - - - - - - - - - - - - - - - - - - - - - - - -. Hi fitfriends, two weeks ago I published the spinach burgers post, as I think you have already had a lot of time to practice, then I ask you, what is an hamburger without bread and its filling?. Today I show you an easy, simple and above all super healthy idea, to take away the craving for those burgers from Burger King that much damage they do to our bodies; well, it does not need that you have that craving, because it is a perfect meal for any day of the week ...
Disculpen yo uso SAFEmode y el problema que tengo que tengo es que cuando estoy juntando gold, se me llena la BP que tengo configurada para que se guarde ahi y no abre la bp que sigue para seguir juntando gold y el character al final de la hunt solo me queda con 2k en gold :S que puedo hacer para solucionar esto ...
Hola JRL,me llamo Julio y me encantaria tener mas fotitos de los pies de Ethel.En FTV recuerdo,cuando empezaba la señal en los 90s aca en Argentina,ella era la presentadora o tenia un programa.Siempre me gusto y si me podes hacer llegar mas fotos o videos descalza seria genial.Aca te paso el mail ...
En Catalyst creemos que los hombres tienen una función central en la creación de centros de trabajo donde tanto hombres como mujeres puedan desarrollarse. Nuestra investigación sugiere que un aspecto medular de este rol es ser ejemplo para otros hombres. A continuación enlistamos algunas acciones que los hombres pueden emprender para desarrollar capacidades que les permitan ser agentes de cambio y modelos influyentes para sus compañeros.. Estos comportamientos pueden hacer la diferencia en tu lugar de trabajo y empezar a crear una masa crítica para el cambio.. ...
Sucrose non-fermenting protein (SNF1)-related kinase (SNRK) is a homologue of the yeast Snf1 kinase, mutants of which fail to thrive when provided with non-fermentable carbon sources. In the mouse lung SNRK expression is specific to capillary endothelial cells [63]. SNRK is phosphorylated and activated by the LKB1 serine/threonine-protein kinase that regulates cell polarity and functions also as a tumor suppressor [64]. In view of the vascular abnormalities found in LKB1 null mice LKB1 has been placed in the VEGF signalling pathway [65]. Together, these lines of evidence suggest that SNRK is also in the VEGF signalling pathway.. Monoamine oxidase A (MAOA) degrades amine neurotransmitters including serotonin. MAOA is located on the X chromosome and its upregulation in IPAH suggests a possible involvement in the development IPAH given the female prederiliction of the disease.. Acid ceramidase or N-acylsphingosine amidohydrolase (ASAH1) cleaves ceramide into sphingosine and a free fatty acid. Both ...
The signalling mechanisms responsible for the hydrolysis of sphingomyelin mediated by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and interferon γ (IFN-γ) in HL-60 cells were investigated. IFN-γ was found to increase selectively the activity of cytosolic, Mg2+-independent, neutral sphingomyelinase. The treatment of HL-60 cells with the combination of 1,25(OH)2D3 and IFN-γ had an additive effect on sphingomyelin hydrolysis, ceramide release and the activity of cytosolic, Mg2+-independent, neutral sphingomyelinase. The pretreatment of HL-60 cells with staurosporine, chelerythrine chloride and bisindolylmaleimide abolished the activity of sphingomyelinase in response to 1,25(OH)2D3 and IFN-γ. Calphostin C, which acts on the regulatory site of protein kinase C (PKC), and Gö 6976, a selective inhibitor of Ca2+-dependent PKC isoforms, inhibited the effect of 1,25(OH)2D3 but had no effect on the IFN-γ-mediated increase in activity of sphingomyelinase. Isoform-specific antibodies were used to deplete ...

neutral ceramidase ELISA Kits | Biocompare.comneutral ceramidase ELISA Kits | Biocompare.com

Compare neutral ceramidase ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, ... Your search returned 9 neutral ceramidase ELISA ELISA Kit across 4 suppliers. ...
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Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities<...Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities<...

Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities. American Journal of ... Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities. / Sikora, Jakub; Dworski, ... Sikora, J., Dworski, S., Jones, E. E., Kamani, M. A., Micsenyi, M. C., Sawada, T., ... Walkley, S. U. (2017). Acid Ceramidase ... title = "Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities", ...
more infohttps://einstein.pure.elsevier.com/en/publications/acid-ceramidase-deficiency-in-mice-results-in-a-broad-range-of-ce

ASAHL/N-acylethanolamine-hydrolyzing Acid Amidase Antibody (AF4886): Novus BiologicalsASAHL/N-acylethanolamine-hydrolyzing Acid Amidase Antibody (AF4886): Novus Biologicals

... and is structurally similar to acid ceramidase (1). NAAA is both a lysosomal and a secreted enzyme, and like acid ceramidase, ...
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Farber disease: understanding a fatal childhood disorder and dissecting ceramide biology | EMBO Molecular MedicineFarber disease: understanding a fatal childhood disorder and dissecting ceramide biology | EMBO Molecular Medicine

Li CM, Park JH, He X, Levy B, Chen F, Arai K, Adler DA, Disteche CM, Koch J, Sandhoff K, et al (1999) The human acid ceramidase ... Eliyahu E, Shtraizent N, Shalgi R, Schuchman EH (2012) Construction of conditional ceramidase knockout mice and in vivo effects ... Acid ceramidase has also been shown to be involved in the resistance of certain tumor cells to chemotherapeutic agents and has ... Park JH, Schuchman EH (2006) Acid ceramidase and human disease. Biochim Biophys Acta 1758: 2133‐ 2138 ...
more infohttp://embomolmed.embopress.org/content/5/6/799

AB0880 Farber Disease Diagnosed as Juvenile Idiopathic Arthritis | Annals of the Rheumatic DiseasesAB0880 Farber Disease Diagnosed as Juvenile Idiopathic Arthritis | Annals of the Rheumatic Diseases

... is an ultra-rare lysosomal storage disorder resulting from the inherited deficiency of the enzyme acid ceramidase, and the ...
more infohttp://ard.bmj.com/content/73/Suppl_2/1092.2

Acid Ceramidase ELISA Kits | Biocompare.comAcid Ceramidase ELISA Kits | Biocompare.com

Compare Acid Ceramidase ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and ... Acid Ceramidase ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a widely used application for detecting and ... Your search returned 15 Acid Ceramidase ELISA ELISA Kit across 3 suppliers. ...
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Ceramidase - WikipediaCeramidase - Wikipedia

Presently, 7 human ceramidases encoded by 7 distinct genes have been cloned: acid ceramidase (ASAH1) - cell survival neutral ... Ceramidase at the US National Library of Medicine Medical Subject Headings (MeSH) EC 3.5.1.23 Molecular and Cellular Biology ... Ceramidase (EC 3.5.1.23, acylsphingosine deacylase, glycosphingolipid ceramide deacylase) is an enzyme which cleaves fatty ... UT Southwestern researchers showed that introducing ceramidase in diabetic mice returned their insulin sensitivity to normal. ...
more infohttps://en.wikipedia.org/wiki/Ceramidase

Potent Inhibition of Acid Ceramidase by Novel B-13 AnaloguesPotent Inhibition of Acid Ceramidase by Novel B-13 Analogues

The most potent in vitro inhibitor of acid ceramidase, B-13, recently revealed to be virtually inactive towards lysosomal acid ... Potent Inhibition of Acid Ceramidase by Novel B-13 Analogues. Denny Proksch, Jan Jasper Klein, and Christoph Arenz ... Indeed, inhibitors of acid ceramidase have been reported to induce cell death and to display potentiating effects to classical ... Herein, we report a novel B-13-derived scaffold for more effective inhibitors of acid ceramidase. Furthermore, we provide hints ...
more infohttps://www.hindawi.com/journals/jl/2011/971618/abs/

Neutral Ceramidase | Springer for Research & DevelopmentNeutral Ceramidase | Springer for Research & Development

Nonlysosomal ceramidase Ceramidase (CDase) is an enzyme that hydrolyzes the N-acyl linkage between a fatty acid and a sphingoid ... Cloning of a ceramidase homologue from Mycobacterium tuberculosis. J Biol Chem. 1999;274:36616-22.CrossRefPubMedGoogle Scholar ... A novel but highly conserved gene family of neutral/alkaline ceramidases. J Biol Chem. 2000b;275:11229-34.CrossRefPubMedGoogle ... Tani M., Ito M. (2018) Neutral Ceramidase. In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. * .RIS Papers ...
more infohttps://rd.springer.com/referenceworkentry/10.1007/978-3-319-67199-4_101723

ASAH2B - Putative inactive neutral ceramidase B - Homo sapiens (Human) - ASAH2B gene & proteinASAH2B - Putative inactive neutral ceramidase B - Homo sapiens (Human) - ASAH2B gene & protein

IPR006823 Ceramidase_alk. IPR038445 NCDase_C_sf. IPR031331 NEUT/ALK_ceramidase_C. ... IPR006823 Ceramidase_alk. IPR038445 NCDase_C_sf. IPR031331 NEUT/ALK_ceramidase_C. ... Putative inactive neutral ceramidase BAdd BLAST. 165. Proteomic databases. PaxDb, a database of protein abundance averages ... Belongs to the neutral ceramidase family.Curated. Phylogenomic databases. evolutionary genealogy of genes: Non-supervised ...
more infohttps://www.uniprot.org/uniprot/P0C7U1

Markedly perturbed hematopoiesis in acid ceramidase deficient mice | HaematologicaMarkedly perturbed hematopoiesis in acid ceramidase deficient mice | Haematologica

Markedly perturbed hematopoiesis in acid ceramidase deficient mice. Shaalee Dworski, Alexandra Berger, Caren Furlonger, Joshua ... Markedly perturbed hematopoiesis in acid ceramidase deficient mice. Shaalee Dworski, Alexandra Berger, Caren Furlonger, Joshua ... Markedly perturbed hematopoiesis in acid ceramidase deficient mice Message Subject (Your Name) has forwarded a page to you from ...
more infohttp://www.haematologica.org/content/early/2015/02/09/haematol.2014.108530

Structural insights into adiponectin receptors suggest ceramidase activityStructural insights into adiponectin receptors suggest ceramidase activity

The ceramidase activity was in the linear range with time and protein concentration. Of note, the linear range with time was ... Because the observed ceramidase activity is low, amidase activity for other natural lipids cannot be ruled out at this stage. ... In this mechanism, which is similar to what was proposed for neutral ceramidase (ref. 12 in the main text), the zinc ion ... These data strongly suggest that all members of the PAQR family may have a ceramidase activity. (c) Sequence alignment of the ...
more infohttp://pubmedcentralcanada.ca/pmcc/articles/PMC5595237/

Blockade of Lysosomal Acid Ceramidase Induces GluN2B-Dependent Tau Phosphorylation in Rat Hippocampal SlicesBlockade of Lysosomal Acid Ceramidase Induces GluN2B-Dependent Tau Phosphorylation in Rat Hippocampal Slices

... Marie-Elaine ... "Blockade of Lysosomal Acid Ceramidase Induces GluN2B-Dependent Tau Phosphorylation in Rat Hippocampal Slices," Neural ...
more infohttps://www.hindawi.com/journals/np/2014/196812/cta/

Ceramidase deficiency | Article about Ceramidase deficiency by The Free DictionaryCeramidase deficiency | Article about Ceramidase deficiency by The Free Dictionary

Biology the absence of a gene or a region of a chromosome normally present Explanation of Ceramidase deficiency ... Looking for Ceramidase deficiency? Find out information about Ceramidase deficiency. ... redirected from Ceramidase deficiency). Also found in: Dictionary, Thesaurus, Medical, Legal, Financial. deficiency. Biology ... Ceramidase deficiency , Article about Ceramidase deficiency by The Free Dictionary https://encyclopedia2.thefreedictionary.com/ ...
more infohttp://encyclopedia2.thefreedictionary.com/Ceramidase+deficiency

YPC1 - Alkaline ceramidase YPC1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) - YPC1 gene & proteinYPC1 - Alkaline ceramidase YPC1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) - YPC1 gene & protein

Alkaline ceramidase YPC1Add BLAST. 316. Proteomic databases. PaxDb, a database of protein abundance averages across all three ... Alkaline ceramidase YPC1 (EC:3.5.1.-*Search proteins in UniProtKB for this EC number. ... "Characterization of yeast mutants lacking alkaline ceramidases YPC1 and YDC1.". Voynova N.S., Mallela S.K., Vazquez H.M., ... Belongs to the alkaline ceramidase family.Curated. Keywords - Domaini. Transmembrane, Transmembrane helix. Phylogenomic ...
more infohttps://www.uniprot.org/uniprot/P38298

Effects of bile diversion in rats on intestinal sphingomyelinases and ceramidase.Effects of bile diversion in rats on intestinal sphingomyelinases and ceramidase.

... Duan, Rui-Dong LU ; Verkade, H J; Cheng, ... Alkaline sphingomyelinase (Alk-SMase) and neutral ceramidase (N-CDase) in the intestinal microvillar membrane are responsible ... Alkaline sphingomyelinase (Alk-SMase) and neutral ceramidase (N-CDase) in the intestinal microvillar membrane are responsible ... article{2fea1906-449d-4cca-ac43-8bace27c1bba, abstract = {Alkaline sphingomyelinase (Alk-SMase) and neutral ceramidase (N-CDase ...
more infohttps://lup.lub.lu.se/search/publication/165122

Plus itPlus it

Abstract 5484: Targeted inhibition of acid ceramidase and C6-ceramide exposure induces synergistic killing in cancer cells. ... Abstract 5484: Targeted inhibition of acid ceramidase and C6-ceramide exposure induces synergistic killing in cancer cells ... Abstract 5484: Targeted inhibition of acid ceramidase and C6-ceramide exposure induces synergistic killing in cancer cells ... Abstract 5484: Targeted inhibition of acid ceramidase and C6-ceramide exposure induces synergistic killing in cancer cells ...
more infohttp://cancerres.aacrjournals.org/content/71/8_Supplement/5484

Plus itPlus it

In ceramide metabolism, ceramidases catalyze the breakdown of ceramide to sphingosine and the inhibition of ceramidase activity ... H9 cells, a human T cell lymphoma cell line, were cultured in medium with the acid ceramidase inhibitor N-oleoyl-ethanolamine ( ... Herein, we report that modulation of ceramide metabolism by extended treatment with a ceramidase inhibitor allows cells to ... extended treatment with an acid ceramidase inhibitor modulates the metabolism of ceramide and selects for a radiation-resistant ...
more infohttp://cancerres.aacrjournals.org/content/66/8_Supplement/1033.2

Farbers Disease, Ceramidase DeficiencyFarber's Disease, Ceramidase Deficiency

Synonym: Ceramidase Deficiency. What is Farbers Disease ?. Farbers disease describes a group of inherited metabolic disorders ... Farbers disease is caused by a deficiency of the enzyme ceramidase. The disease occurs when both parents carry and pass on the ...
more infohttp://neurologycolorado.com/farbers.htm

ACER1 elisa kit | Mouse Alkaline ceramidase 1 (ACER1) ELISA Kit-NP 597999.1ACER1 elisa kit | Mouse Alkaline ceramidase 1 (ACER1) ELISA Kit-NP 597999.1

Mouse Alkaline ceramidase 1 (ACER1) ELISA Kit-NP_597999.1 (MBS7235867) product datasheet at MyBioSource, ELISA Kits ... ACER1 elisa kit :: Mouse Alkaline ceramidase 1 (ACER1) ELISA Kit. Catalog #. MBS7235867 .mycenter { display: block; margin-left ... alkaline ceramidase 1; alkCDase 1; alkaline CDase 1; acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3; N- ... Belongs to the alkaline ceramidase family.. Protein type: Hydrolase; Lipid Metabolism - sphingolipid; EC 3.5.1.23; Endoplasmic ...
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Ceramidase definitionCeramidase definition

ceramidase cer·am·i·dase (sə-rāmĭ-dās, -dāz) n. An enzyme that catalyzes the breakdown of ceramides into sphingosine and ... Definithing > Dictionary > c > Ceramidase. Ceramidase. ceramidase cer·am·i·dase (sə-rāmĭ-dās, -dāz). n.. An enzyme that ... Disclaimer: Ceramidase definition / meaning should not be considered complete, up to date, and is not intended to be used in ...
more infohttps://definithing.com/define-dictionary/ceramidase/

123MyMD » Acid Ceramidase123MyMD » Acid Ceramidase

123MyMD.com and its services are for informational purposes only and are not a substitute for professional medical or health advice, examination, diagnosis, or treatment. Always seek the advice of your physician or other qualified health professionals before starting any new treatment, making any changes to existing treatment, or altering in any way your current exercise or diet regimen. Do not delay seeking or disregard medical advice based on information on this site. Medical information changes rapidly and while 123MyMD.com and its content providers make every efforts to update the content on the site, some information may be out of date. No health information on 123MyMD.com, including information about herbal therapies and other dietary supplements, is regulated or evaluated by the Food and Drug Administration and therefore the information should not be used to diagnose, treat, cure, or prevent any disease without the supervision of a medical doctor.. ...
more infohttp://www.123mymd.com/dictionary/acid-ceramidase-2/

Farbers Lipogranulomatosis or Ceramidase Deficiency|Types|Causes|Symptoms|TreatmentFarber's Lipogranulomatosis or Ceramidase Deficiency|Types|Causes|Symptoms|Treatment

Learn more about Farbers Lipogranulomatosis or Ceramidase Deficiency, Its Types, Causes, Risk Factors, Symptoms, Treatment, ... The ASAH1 gene is a gene that gives instructions for production of an enzyme known as acid ceramidase. Acid ceramidase is ... Farbers lipogranulomatosis is also known as ceramidase deficiency, Farber disease and acid ceramidase deficiency. ... Farbers Lipogranulomatosis or Ceramidase Deficiency: Types, Causes, Symptoms, Treatment. Reviewed By:. Pramod Kerkar, M.D., ...
more infohttps://www.epainassist.com/genetic-disorders/farbers-lipogranulomatosis-or-ceramidase-deficiency

acer2, alkaline ceramidase 2 - Creative Biogeneacer2, alkaline ceramidase 2 - Creative Biogene

The ceramidase ACER2 hydrolyzes very long chain ceramides to generate;sphingosine (Xu et al., 2006 (PubMed 16940153)). ... ACER2; alkaline ceramidase 2; ASAH3L, N acylsphingosine amidohydrolase 3 like; FLJ41587; haCER2; alkCDase 2; alkaline CDase 2; ...
more infohttps://www.creative-biogene.com/symbolsearch_acer2.html
  • Furthermore, we provide hints for an introduction of basic functional groups at an alternative site of the B-13 scaffold that do not interfere with acid ceramidase inhibition in vitro . (hindawi.com)
  • Here, we describe a micelleplex system based on an amphiphilic and cationic triblock copolymer, which can systemically deliver siRNA targeting the acid ceramidase (AC) gene for cancer therapy. (naver.com)
  • Ceramide, a key molecule in the metabolism of sphingolipids, is converted by ceramidase to sphingosine, and phosphorylated by ceramide kinase to form ceramide-1-phosphate (C1P). (chat-shuffle.net)
  • These represent the first inducible genetic models that acutely manipulate adiponectin receptor signaling in adult mouse tissues, which allows us to directly assess AdipoR signaling on glucose and lipid metabolism.Overexpression of either adiponectin receptor isoform in the adipocyte or hepatocyte is sufficient to enhance ceramidase activity, whole body glucose metabolism, and hepatic insulin sensitivity, while opposing hepatic steatosis. (hepaton.com)
  • When challenged with a leptin-deficient genetic model of type 2 diabetes, AdipoR2 expression in adipose or liver is sufficient to reverse hyperglycemia and glucose intolerance.These observations reveal that adiponectin is critical for AdipoR-induced ceramidase activation which enhances hepatic glucose and lipid metabolism via rapidly acting 'cross-talk' between liver and adipose tissue sphingolipids. (hepaton.com)
  • Acid ceramidase is present in the compartments, which digest and recycle materials in the cell by breaking down the fats known as ceramides for the purpose of getting them used by the body. (epainassist.com)
  • Lack of activity of acid ceramidase can develop ceramides in the lysosomes of tissues and cells in the colon, muscles used for movement, bone, cartilage, lung and liver. (epainassist.com)
  • However, introduction of weakly basic groups at the ω -position of the fatty acid moiety of B-13 led to a significant reduction of potency towards acid ceramidase from cellular extracts. (hindawi.com)
  • Effects of bile diversion in rats on intestinal sphingomyelinases and ceramidase. (lu.se)
  • UT Southwestern researchers showed that introducing ceramidase in diabetic mice returned their insulin sensitivity to normal. (wikipedia.org)
  • Ceramidase expression facilitates membrane turnover and endocytosis of" by Usha Acharya, Michael Beth Mowen et al. (umassmed.edu)
  • Here, we determined crystal structures of ADIPOR2 bound to a FFA molecule and demonstrate that ADIPOR2 possesses an intrinsic basal ceramidase activity enhanced by adiponectin. (pubmedcentralcanada.ca)
  • Because we found that ADIPOR1 also possesses an intrinsic ceramidase activity, we suspect that the two distinct structures may represent key steps of the ADIPORs enzymatic activity. (pubmedcentralcanada.ca)
  • The ceramidase activity is low, however, and further studies will be required to fully characterize ADIPORs enzymatic parameters and their substrate specificity. (pubmedcentralcanada.ca)
  • Indeed, inhibitors of acid ceramidase have been reported to induce cell death and to display potentiating effects to classical radio- or chemo therapy in a number of in vitro and in vivo cancer models. (hindawi.com)
  • In contrast, a number of weakly basic B-13 analogues have been shown to accumulate in the acidic compartments of living cells and to efficiently inhibit lysosomal acid ceramidase. (hindawi.com)
  • Here, we show that expression of ceramidase facilitates the dissolution of incompletely formed and inappropriately located elements of rhabdomeric membranes in ninaE(I17) mutants lacking the G protein receptor Rh1 in R1-R6 photoreceptor cells. (umassmed.edu)
  • Acid ceramidase confers radioresistance to glioblastoma cells. (mcw.edu)
  • Transgenic expression of ceramidase suppresses retinal degeneration in Drosophila arrestin and phospholipase C mutants. (umassmed.edu)
  • Ceramidase expression facilitates the endocytic turnover of Rh1. (umassmed.edu)
  • Although ceramidase expression aids the removal of internalized rhodopsin, it does not affect the turnover of Rh1 in photoreceptors maintained in dark, where Rh1 is not activated and thus has a slower turnover and a long half-life. (umassmed.edu)
  • Therefore, the phenotypic consequence of ceramidase expression in photoreceptors is caused by facilitation of endocytosis. (umassmed.edu)