A semi-synthetic cephalosporin antibiotic.
A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
A cephalorsporin antibiotic.
Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative.
A cephalosporin antibiotic.
Six-carbon alicyclic hydrocarbons.
Hard or soft soluble containers used for the oral administration of medicine.
Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Personal names, given or surname, as cultural characteristics, as ethnological or religious patterns, as indications of the geographic distribution of families and inbreeding, etc. Analysis of isonymy, the quality of having the same or similar names, is useful in the study of population genetics. NAMES is used also for the history of names or name changes of corporate bodies, such as medical societies, universities, hospitals, government agencies, etc.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Hydrazine substituted by one methyl group.
A species of STAPHYLOCOCCUS similar to STAPHYLOCOCCUS HAEMOLYTICUS, but containing different esterases. The subspecies Staphylococcus hominis novobiosepticus is highly virulent and novobiocin resistant.
A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.
Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
Enzymes that cause coagulation in plasma by forming a complex with human PROTHROMBIN. Coagulases are produced by certain STAPHYLOCOCCUS and YERSINIA PESTIS. Staphylococci produce two types of coagulase: Staphylocoagulase, a free coagulase that produces true clotting of plasma, and Staphylococcal clumping factor, a bound coagulase in the cell wall that induces clumping of cells in the presence of fibrinogen.
Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Countries in the process of change with economic growth, that is, an increase in production, per capita consumption, and income. The process of economic growth involves better utilization of natural and human resources, which results in a change in the social, political, and economic structures.
Sequential operating programs and data which instruct the functioning of a digital computer.
Errors in prescribing, dispensing, or administering medication with the result that the patient fails to receive the correct drug or the indicated proper drug dosage.
Prospective patient listings for appointments or treatments.
Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency.
Countries that have reached a level of economic achievement through an increase of production, per capita income and consumption, and utilization of natural and human resources.
The giving of drugs, chemicals, or other substances by mouth.
Condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification.
Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3.
Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.
Death and putrefaction of tissue usually due to a loss of blood supply.
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
Methods, procedures, and tests performed to diagnose disease, disordered function, or disability.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
An autosomal dominant porphyria that is due to a deficiency of COPROPORPHYRINOGEN OXIDASE in the LIVER, the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include both neurological symptoms and cutaneous lesions. Patients excrete increased levels of porphyrin precursors, 5-AMINOLEVULINATE and COPROPORPHYRINS.
Porphyrins with four methyl and four propionic acid side chains attached to the pyrrole rings. Elevated levels of Coproporphyrin III in the urine and feces are major findings in patients with HEREDITARY COPROPORPHYRIA.
An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.
A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.
A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
Colorless reduced precursors of porphyrins in which the pyrrole rings are linked by methylene (-CH2-) bridges.

The effect of three frequently applied antibiotics on the colonization resistance of the digestive tract of mice. (1/52)

The influence of treatment with increasing oral doses of three absorbable antibiotics on the colonization resistance of the digestive tract was investigated in mice. Mice treated with ampicillin or epicillin in any of the applied doses had a strongly decreased colonization resistance as demonstrated by 'bacterial overgrowth' after contamination with resistant strains of Escherichia coli. After a treatment period 2 weeks, Streptococcus faecalis became resistant in a number of animals. Oral treatment with cephradine on the other hand had no obvious influence on the endogenous flora of the mice, nor was the colonization resistance decreased.  (+info)

Factors associated with antibiotic resistance in coliform organisms from community urinary tract infection in Wales. (2/52)

Routine susceptibility data for urinary coliform isolates from community practice were analysed in comparison with dispensed antibiotic prescriptions for all conditions and social deprivation data for Bro Taf and North Wales Health Authorities for financial years 1996--1998. Prescribing rates and resistance rates varied widely between practices. Among isolates from practices with high usage of an antibiotic, rates of resistance to that antibiotic tended to be high, and usage correlated significantly with resistance between practice population units. Cross-correlations were found between usage of one antibiotic and resistance to another, particularly for trimethoprim and ampicillin. Usage, particularly of trimethoprim, was associated with multi-resistance to up to four antibiotics. Resistance was more frequent in isolates from males, children and the elderly. Ampicillin resistance correlated with social deprivation. Analyses including or excluding potential repeat isolates yielded closely similar results. Indices reflecting sampling behaviour (laboratory coliform positivity rates, positivity per 1000 registered patients, specimens submitted per 1000 registered patients) varied widely between surgeries, suggesting lack of consensus on urine sampling policies. These indices showed only weak correlations with usage or resistance. Associations between resistance and usage were compared for isolates from two patient subsets that were likely to differ in their proportions of non-Escherichia coli isolates: female patients aged 16--55 years; and males, children and patients aged >55 years. The latter showed higher base levels of resistance, but the associations of resistance with usage were statistically indistinguishable for the two populations. The results suggest that usage of antibiotics in a practice population may affect the rate of urinary infection caused by resistant coliform organisms in that population.  (+info)

Intraperitoneal ciprofloxacin and rifampicin versus cephradine as initial treatment of (C)APD-related peritonitis: a prospective randomized multicenter comparison (CIPPER trial). (3/52)

OBJECTIVE: The initial treatment of peritonitis has evolved from single-agent to combination regimens. The initial response rates improved with these newer regimens but relapsing peritonitis continues to occur. For biofilm-embedded or intracellularly sequestrated bacteria, a combination of intracellularly- and biofilm-active agents such as ciprofloxacin and rifampicin might be beneficial. Many Dutch centers continue to use cephradine as initial treatment, claiming clinically adequate responses with this regimen. We compared the impact of these two regimens on outcome in patients who developed a new episode of peritonitis. DESIGN: Prospective randomized open trial. SETTING: Multicenter study including 14 Dutch dialysis units. PATIENTS AND INTERVENTIONS: From October 1996 to October 1999, 367 patients from 14 centers were randomized to be treated with ciprofloxacin + rifampicin (CR; each 50 mg/L) or cephradine (C; 250 mg/L) in case of peritonitis. Of these 367 patients, 98 developed peritonitis, 44 of whom were treated with CR and 54 with C. MAIN OUTCOME MEASURES: Clinical response, divided into early (during the 2 weeks of therapy) and late (including the following 4 weeks) response. Success was defined as disappearance of all signs and symptoms by days 4-6, through day 42. Bacteriological response was either success (eradication) or failure (persistence, superinfection, or eradication with relapse/reinfection). RESULTS: The groups were comparable for age, sex, duration of continuous ambulatory/automated peritoneal dialysis, and occurrence of diabetes. Bacteriological cultures in both groups revealed predominantly gram-positive micro-organisms. Initial and late clinical successes were obtained in 27/54 and 20/54 episodes (50% and 37%) in the C group, and 33/44 and 28/44 episodes (75% and 63.6%) in the CR group (p = 0.021 and p = 0.019). Bacteriological success occurred in 29.6% in the C group, and in 59.1% in the CR group (p= 0.026), with failure in 46.3% and 18.2%, respectively. Peritonitis episodes were bacteriologically not evaluable in 24.1% of episodes in the C group and 22.7% of episodes in the CR group, due mostly to no growth in the initial culture. CONCLUSION: The CIPPER Trial showed ciprofloxacin + rifampicin to be superior to cephradine as empiric treatment of peritonitis.  (+info)

Prolonged intestinal absorption of cephradine with chitosan-coated ethylcellulose microparticles in rats. (4/52)

Cephradine-containing ethylcellulose microparticles (MPC) were prepared by the solvent evaporation method. Chitosan-coated MPC (Chi-MPC) were prepared by doping MPC with viscous chitosan solution and subsequently drying. When fluorescein isothiocyanate (FITC)-labeled chitosan-coated ethylcellulose microparticles without drug were administered intraduodenally, they moved slowly in the intestine, that is, most of them were retained at the upper and middle parts of the small intestine for more than 8 h, which is considered due to mucoadhesive properties of coated chitosan. When MPC and Chi-MPC was incubated at 37 degrees C in the JP 14 second fluid, pH 6.8, both released the drug slowly with similar release rates. Cephradine solution and suspension, MPC and Chi-MPC were administered intraduodenally to investigate intestinal drug absorption. Only Chi-MPC suppressed the initial plasma level and maintained the plasma concentration for a long time up to 24 h, suggesting Chi-MPC would be useful for prolonged intestinal absorption of cephradine.  (+info)

Is antibiotic penetration compromised in the ischaemic tissues of patients undergoing amputation? (5/52)

Antibiotic prophylaxis is indicated for patients undergoing amputation for severe ischaemia or gangrene. However, the adequacy of tissue levels of antibiotics in ischaemic tissue is not known. In this study the serum and tissue antibiotic levels were measured after intravenous administration of metronidazole (15 mg/kg body weight) and cephradine (20 mg/kg body weight). In 11 patients, venous samples were taken at time 0 (induction of anaesthesia) 10, 30 and 60 min. Samples of 2 g each of fat and muscle were collected from the amputation site and three distal sites. Metronidazole and cephradine levels were measured and the degree of limb ischaemia estimated preoperatively by an isotope limb blood flow method. Our results indicate that both metronidazole and cephradine penetrate ischaemic tissues to levels equivalent of a Mean Inhibitory Concentration (MIC) 50 for most organisms encountered in vascular surgery, and that the degree of ischaemia does not alter this.  (+info)

Occupational contact allergy to cephalosporins. (6/52)

Contact sensitivity to systemically administered drugs occurs mainly among healthcare workers and is frequently caused by antibiotics. A 32-year-old nurse presented with a 1(1/2) year history of hand dermatitis and a 2 month history of palpebral eczema, which were clearly work related. Patch tests with standard and gloves series were negative. Testing of the products commonly handled by the patient were positive for cefradine and cefazolin. Testing of other cephalosporins the patient had not come in contact with were also positive for cefuroxime, ceftriaxone, and cefotaxime. This cross-reactivity may be explained by similar molecular structures. The patient stopped preparing cephalosporin solutions for systemic administration and the lesions cleared.  (+info)

Comparative study of cephradine and amoxicillin-clavulanate in the treatment of recurrent urinary tract infections. (7/52)

Eighty-eight female patients with a history of recurrent urinary tract infections were treated according to a randomization scheme with either 1 g of cephradine every 12 h (47 patients) or 375 mg of amoxicillin-clavulanate every 8 h (41 patients) for 7 days. The treatments were equally effective (cure rates of 89% for cephradine and 88% for amoxicillin-clavulanate) and showed similar relapse rates (cephradine, 14%; amoxicillin-clavulanate, 11%). Adverse effects were similar in both groups (cephradine, 23%; amoxicillin-clavulanate, 22%).  (+info)

Comparison of in vitro activity of cephalexin, cephradine, and cefaclor. (8/52)

Inhibitory activity of cephalexin, cephradine, and cefaclor was compared by the WHO-ICS agar dilution technique. Cefaclor was substantially more active against staphylococci, streptococci, gonococci, meningococci, Haemophilus, Escherichia coli, Klebsiella pneumoniae, Citrobacter diversus, Proteus mirabilis, salmonellae, and shigellae than was cephalexin, which in turn was more active than cephradine. Cefaclor appeared to be less resistant to staphylococcal penicillinase than did the other two agents. None of these cephalosporins was active against Enterobacter, Serratia, indole-positive Proteeae, Pseudomonas, or Bacteroides fragilis.  (+info)

Methicillin-resistant staphylococci were tested for susceptibility to cephradine, cephaloridine, cephalexin, and cefuroxime and 30 degree C and 37 degree C on ordinary media and on media of enhanced osmotic strength. The coagulase-negative strains were divided into Staphylococcus epidermis and Staphylococcus hominis. Generally the number of susceptible strains decreased with low incubation temperature and osmotic support. When Staphylococcus aureus was tested against cephalexin and cefuroxime, most were susceptible at 37 degree C whereas all were resistant at 30 degree C. A similar trend was found in the case of cephradine, where it was accentuated by osmotic support. While almost all strains of Staph. epidermidis were sensitive to all four drugs under all test conditions, the susceptibility of Staph. hominis was generally decreased by either lower incubation temperature or osmotic support or both.. ...
Cephradine (Eskacef - SKF; Velosef - Squibb) is a new semi-synthetic cephalosporin for oral use. Like other cephalosporins it is active against both Gram-negative and Gram-positive pathogens, apparently including penicillinase-producing staphylococci (though this has been questioned1). It is advertised as having new striking power, but from the data provided its spectrum of activity closely resembles that of cephalexin (Ceporex - Glaxo; Keflex - Lilly),2 and the promotional literature on cephradine makes no direct comparison between the two drugs.. ...
VOLVOCEF (Cephradine) is a first-generation cephalosporin antibacterial given orally and by parenteral route in the treatment of susceptible infections and
The IUPHAR/BPS Guide to Pharmacology. cephradine ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Read the side effects of Cephradine as described in the medical literature. In case of any doubt consult your doctor or pharmacist.
A significant number of paediatric surgical patients undergone clean surgical procedures. Most of the paediatric surgeon use perioperative prophylactic antibiotic in this clean procedure because of undue fear of infection in their mind. The objective of this study is to evaluate whether the use of perioperative prophylactic antibiotics have an effect to prevent post operative wound infection in clean operation in paediatric surgical patients. This study was conducted in the paediatric surgery department of Bangabandhu Sheikh Mujib Medical University and some private clinics of Dhaka city from January 2009 to December 2009. Two hundred patients who were undergone clean elective surgical procedure on day case basis were included in this study. They were divided into two equal groups (Group A and Group B). The patients of Group A were given intransverse Cephradine 30 minutes before incision and then oral Cephradine was advised postoperatively for 7 days. The patients of Group B were not given any
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Product Description Product Name: MERRIC Cap 250mg 10sProduct Form: CapsulesPack Size: 10sManufactured By: MEGA PHARMACEUTICALS LTDGeneric Category: CEPHALOSPORIN ANTI-BACTERIALIngredients: Cephradine
Susceptibility of Anaerobic Bacteria to Cefoxitin and Related Compounds: Cephalothin, cefazolin, cephradine, and cefoxitin inhibited more than 75% of 326 anaero
Pill with imprint biocraft 113 is Green, Capsule-shape and has been identified as Cephradine 500 MG. It is supplied by Teva Pharmaceuticals USA.
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TY - JOUR. T1 - Characterization of the Oral Absorption of β-Lactam Antibiotics. I. Cephalosporins. T2 - Determination of Intrinsic Membrane Absorption Parameters in the Rat Intestine In Situ. AU - Sinko, Patrick J.. PY - 1988/10. Y1 - 1988/10. N2 - The oral absorption of five cephalosporin antibiotics, cefaclor, cefadroxil, cefatrizine, cephalexin, and cephradine, has been studied using a single-pass intestinal perfusion technique in rats. Intrinsic membrane absorption parameters, unbiased by the presence of an aqueous permeability (diffusion or stagnant layer), have been calculated utilizing a boundary layer mathematical model. The resultant intrinsic membrane absorption parameters are consistent with a significant carrier-mediated, Michaelis-Menten-type kinetic mechanism and a small passive component in the jejunum. Cefaclor colon permeability is low and does not exhibit concentration dependent behavior. The measured carrier parameters (±SD) for the jejunal perfusions are as follows: ...
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Forty-seven Salmonella Typhimurium (33 zoonotic, 14 clinical) strains were tested for antimicrobial resistance using the standard disk diffusion method. The presence of relevant resistance genes and class 1 integrons were investigated by using PCR. Pulsed-field gel electrophoresis (PFGE) and plasmid profiling were carried out to determine the genomic diversity of Salmonella Typhimurium. Approximately 57.4 of the S. Typhimurium strains were multidrug resistant (MDR) and showed high resistance rates to tetracycline (70.2), sulfonamides (57.4), streptomycin (53.1), ampicillin (29.7), nalidixic acid (27.6), kanamycin (23.4), chloramphenicol (21.2), and trimethoprim (19.1). Resistance towards cephalosporins was noted for cephalothin (27.6), cephradine (21.2), amoxicillin clavulanic acid (17.0), and cephalexin (17.0). Resistance genes, bla(TEM), strA, aadA, sul1, sul2, tetA, tetB, and tetC, were detected among the drug-resistant strains. Thirty-three strains (70.2) carried class 1 integrons, which ...
Bestatin [(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl-L-leucine], a dipeptide containing an unusual amino acid, has been used clinically as an anticancer agent in p.o. dosage form. We examined the transport characteristics of [3H]bestatin by rabbit intestinal brush-border membrane vesicles. Bestatin uptake was stimulated by an inward H+ gradient (overshoot phenomenon) and by an interior-negative membrane potential. About half of the apparent bestatin uptake at 1 mM by brush-border membrane vesicles was estimated as binding to the membranes. The affinity constant for the bestatin transport was 0.52 mM. The uptake of bestatin by brush-border membrane vesicles was inhibited by p.o. cephalosporins and dipeptides, but not by amino acids. In vesicles preloaded with either bestatin, cephradine or glycylsarcosine, the uptake of [3H]bestatin was stimulated markedly (countertransport effect). These results indicate that bestatin is transported via the H+/dipeptide transport system in rabbit intestinal ...
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McAfee and Smith recommend a course of oral antibiotics, usually oxacillin sodium or cephradine, and assert that surgery and ...
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The official start to its development started in December 1986 when Merck's president, Edward Scolnick, announced that they would start a comprehensive AIDS research program. They started a laboratory dedicated to AIDS research in West Point, Pennsylvania and placed Emilio Emini in charge of the laboratory.[11] A couple months later on January, 1987, a team of researchers consisting of Emilio Emini, Joel Huff, and Irving Sigal, kickstarted their studies by basing their project off of earlier research on the protease enzyme, renin.[5] They were the ones who started the process of research and development into protease inhibitors and its relation to the virus. Over a year later, in July 1988, Nancy Kohl, Emilio Emini, et al., published in the Proceedings of the National Academy of the Science about the idea of inhibiting the protease.[11] On February, 1989, Manuela Navia, Paula Fitzgerald, et al., published a paper that showed the three-dimensional structure of HIV's protease enzyme.[5] Other ...
... is typically used to treat hypothyroidism,[9] and is the treatment of choice for people with hypothyroidism,[10] who often require lifelong thyroid hormone therapy.[11] It may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing.[12][13] Levothyroxine is also used as interventional therapy in people with nodular thyroid disease or thyroid cancer to suppress thyroid-stimulating hormone (TSH) secretion.[14] A subset of people with hypothyroidism treated with an appropriate dose of levothyroxine will describe continuing symptoms despite TSH levels in the normal range.[11] In these people, further laboratory and clinical evaluation is warranted as they may have another cause for their symptoms.[11] Furthermore, it is important to review their medications and possible dietary supplements as several medications can affect thyroid hormone levels.[11] Levothyroxine is also used to treat subclinical ...
... is a low cost drug.[7] In the United States, Salix Pharmaceuticals holds a US Patent for rifaximin and markets the drug under the name Xifaxan.[17][18] In addition to receiving FDA approval for traveler's diarrhea and (marketing approved for)[18] hepatic encephalopathy, rifaximin received FDA approval for IBS in May 2015.[19] No generic formulation is available in the US and none has appeared due to the fact that the FDA approval process was ongoing. If rifaximin receives full FDA approval for hepatic encephalopathy it is likely that Salix will maintain marketing exclusivity and be protected from generic formulations until March 24, 2017.[18] Rifaximin is approved in 33 countries for GI disorders.[20][21] On August 13, 2013, Health Canada issued a Notice of Compliance to Salix Pharmaceuticals Inc. for the drug product Zaxine.[22] In India it is available under the brand names Ciboz and Xifapill.[citation needed] In Russia and Ukraine the drug is sold under the name Alfa Normix ...
Long-term use of methylprednisolone, as with all corticosteroids, can be associated with hyperglycemia, decreased resistance to infection, swelling of face, weight gain, congestive cardiac insufficiency, fluid and sodium retention, edema, hypertension, increased eye pressure, glaucoma, osteoporosis, and psychosis, especially when used at high doses.[11][12] The most serious side effect occurs after the adrenal glands cease natural production of cortisol, which methylprednisolone will replace. Abrupt cessation of the drug after this occurs can result in a condition known as Addisonian crisis, which can be fatal. To prevent this, the drug is usually prescribed with a tapering dose, including a predosed "dose pack" detailing a specific number of tablets to take at designated times over a several-day period. Pharmacists sometimes advise that this drug may cause sleeplessness and "down" moods. Measles and chicken pox are very dangerous and potentially fatal for people on methylprednisolone therapy. ...
Important drug interactions are rare.[27][28] However, the most significant major drug interaction concern is the decreased activation of clopidogrel when taken together with omeprazole.[29] Although still controversial,[30] this may increase the risk of stroke or heart attack in people taking clopidogrel to prevent these events. This interaction is possible because omeprazole is an inhibitor of the enzymes CYP2C19 and CYP3A4.[31] Clopidogrel is an inactive prodrug that partially depends on CYP2C19 for conversion to its active form. Inhibition of CYP2C19 may block the activation of clopidogrel, which could reduce its effects.[32][33] Almost all benzodiazepines are metabolised by the CYP3A4 and CYP2D6 pathways, and inhibition of these enzymes results in a higher AUC (i.e., the total effect over time of a given dose). Other examples of drugs dependent on CYP3A4 for their metabolism are escitalopram,[34] warfarin,[35] oxycodone, tramadol, and oxymorphone. The concentrations of these drugs may ...
Bonow RO, Carabello BA, Kanu C, et al. (August 2006). "ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons". Circulation. 114 (5): e84-231. doi:10.1161/CIRCULATIONAHA.106.176857. PMID 16880336 ...
... has been investigated for use as a radiation countermeasure. Its value as a radiation countermeasure is based mainly on its stimulation of production of white blood cells and platelets.[6] Its potential use as a radiation countermeasure was developed by the Armed Forces Radiobiology Research Institute (AFRRI) and subsequently studied by AFRRI and Hollis-Eden Pharmaceuticals under the proposed brand name Neumune for the treatment of acute radiation syndrome.[6][7] The clinical trials with rhesus monkeys were successful. According to the Hollis-Eden report, only 12.5% of the 40 Neumune-treated animals died versus 32.5% in the placebo group.[8] Hollis-Eden had applied for a contract from the U.S. Government under the BioShield Request for Proposals (RFP) for radiation countermeasures. After being encouraged for 2.5 years that Neumune was in the competitive range, on March 9, 2007, the RFP was canceled by HHS. According to HHS, "the product was no longer in the competitive ...
... (CBZ), sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain.[1] It is not effective for absence or myoclonic seizures.[1] It is used in schizophrenia along with other medications and as a second-line agent in bipolar disorder.[3][1] Carbamazepine appears to work as well as phenytoin and valproate for focal and generalised seizures.[4] Common side effects include nausea and drowsiness.[1] Serious side effects may include skin rashes, decreased bone marrow function, suicidal thoughts, or confusion.[1] It should not be used in those with a history of bone marrow problems.[1] Use during pregnancy may cause harm to the baby; however, stopping the medication in pregnant women with seizures is not recommended.[1] Its use during breastfeeding is not recommended.[1] Care should be taken in those with either kidney or liver problems.[1] Carbamazepine was discovered in 1953 by Swiss chemist Walter ...
... is an allosteric endocannabinoid, as it is a negative allosteric modulator of the CB1 receptor.[4][5] Pregnenolone is involved in a natural negative feedback loop against CB1 receptor activation in animals.[6][better source needed] It prevents CB1 receptor agonists like tetrahydrocannabinol, the main active constituent in cannabis, from fully activating the CB1 [6][better source needed] Pregnenolone has been found to bind with high, nanomolar affinity to microtubule-associated protein 2 (MAP2) in the brain.[7][8] In contrast to pregnenolone, pregnenolone sulfate did not bind to microtubules.[7][8] However, progesterone did and with similar affinity to pregnenolone, although unlike pregnenolone, it did not increase binding of MAP2 to tubulin.[7][8] Pregnenolone was found to induce tubule polymerization in neuronal cultures and to increase neurite growth in PC12 cells treated with nerve growth factor.[7][8] As such, pregnenolone may control formation and stabilization of microtubules ...
... has little systemic absorption, and is considered safe for topical use in adults and children over the age of 2 months. The FDA has assigned it as pregnancy category B. Animal studies have shown no effects on fertility or teratogenicity, but studies in humans have not been performed. The excretion of permethrin in breastmilk is unknown, and breastfeeding is recommended to be temporarily discontinued during treatment.[11] According to the Connecticut Department of Public Health, permethrin "has low mammalian toxicity, is poorly absorbed through the skin, and is rapidly inactivated by the body. Skin reactions have been uncommon."[14] Excessive exposure to permethrin can cause nausea, headache, muscle weakness, excessive salivation, shortness of breath, and seizures. Worker exposure to the chemical can be monitored by measurement of the urinary metabolites, while severe overdose may be confirmed by measurement of permethrin in serum or blood plasma.[15] Permethrin does not present any ...
where CL is total body clearance (L/h), BSA is total body surface area (m2), AAG and ALB represent alpha1 acid glycoprotein and albumin plasma concentrations (g/L) respectively, and AGE is the patients age (years).[13] HEP12 represents a measure of hepatic dysfunction, affecting clearance of docetaxel. This final model accounted for a modest proportion of patients and identified most of the patients varying from the model (population median of CL = 35.6 L/h) as having hepatic dysfunction, indicating hepatic function as the most unpredictable factor with regards to clearance variability.[13] Patients with significant hepatic dysfunction had an approximately 30% decrease in clearance of docetaxel and were also at a higher risk of toxicity poisoning from docetaxel treatment.[13] Clearance has been shown from population pharmacokinetic studies to decrease significantly with age, increased alpha1 acid glycoprotein and albumin concentrations and decreased body surface area.[13] Renal impairment is ...
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Human exposure to methoxychlor occurs via air, soil, and water,[7] primarily in people who work with the substance or who are exposed to air, soil, or water that has been contaminated. It is unknown how quickly and efficiently the substance is absorbed by humans who have been exposed to contaminated air or via skin contact.[7] In animal models, high doses can lead to neurotoxicity.[7] Some methoxychlor's metabolites have estrogenic effects in adult and developing animals before and after birth.[7] One studied metabolite is 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) which shows reproductive toxicity in an animal model by reducing testosterone biosynthesis.[8][9] Such effects adversely affect both the male and female reproductive systems. It is expected that this "could occur in humans" but has not been proven.[7] While one study has linked methoxychlor to the development of leukemia in humans, most studies in animals and humans have been negative, thus the EPA has determined that it is ...
... , also known as eltanolone (INN), is an endogenous neurosteroid that is biosynthesized from progesterone.[1] It is a positive allosteric modulator of the GABAA receptor,[1] as well as a negative allosteric modulator of the glycine receptor,[2] and is known to have sedative, anxiolytic, anesthetic, and anticonvulsant effects.[1][2][3] It was investigated for clinical use as a general anesthetic, but produced unwanted side effects such as convulsions on occasion, and for this reason was never marketed.[2][4] During pregnancy, pregnanolone and allopregnanolone are involved in sedation and anesthesia of the fetus.[5][6] ...
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A component in various medicinal plants (e.g. Scutellaria baicalensis), chrysin is a dihydroxyflavone, a type of flavonoid.[6] It is also found in honey, propolis, the passion flowers, Passiflora caerulea and Passiflora incarnata, in Oroxylum indicum,[2] carrots,[1] chamomile,[7] many fruits, and in mushrooms, such as the mushroom, Pleurotus ostreatus.[6] It is extracted from various plants,[1] such as the blue passion flower (Passiflora caerulea).[1] The amount of chrysin in honey from various plant sources is about 0.2 mg per 100 g.[8] Chrysin is typically found at higher amounts in propolis than in honey.[9] A 2010 study found the amount of chrysin was 0.10 mg/kg in honeydew honey, and 5.3 mg/kg in forest honeys.[10] A 2010 study found the amount of chrysin in propolis was as much as 28 g/L.[10] A 2013 study found the amount of chrysin in various mushrooms from the island of Lesvos, Greece varied between 0.17 mg/kg in Lactarius deliciosus to 0.34 mg/kg in Suillus bellinii.[10] ...
Recreational use of tianeptine is rare[according to whom?] and thus far has only been seen in persons already using multiple substances for recreational purposes.[citation needed] In 2001, Singapore's Ministry of Health restricted tianeptine prescribing to psychiatrists due to its recreational potential,[49] In 2003, Bahrain classified it a controlled substance due to increasing reports of misuse and recreational use.[50] Between 1989 and 2004, in France 141 cases of recreational use were identified, correlating to an incidence of 1 to 3 cases per 1000 persons treated with tianeptine and 45 between 2006 and 2011. The main reason for recreational use is to achieve an anxiolytic effect. According to Servier, stopping of treatment with tianeptine is difficult, due to the possibility of withdrawal symptoms in a person. The severity of the withdrawal is dependent on the daily dose, with high doses being extremely difficult to quit.[51][better source needed][52][53] In 2007, according to French Health ...
... is very toxic to cats which cannot tolerate the therapeutic doses for dogs.[7] This is associated with UGT1A6 deficiency in cats, the enzyme responsible for metabolizing cypermethrin. As a consequence, cypermethrin remains much longer in the cat's organs than in dogs or other mammals and can be fatal in large doses. In male rats cypermethrin was shown to exhibit a toxic effect on the reproductive system. After 15 days of continual dosing, both androgen receptor levels and serum testosterone levels were significantly reduced. These data suggested that cypermethrin can induce impairments of the structure of seminiferous tubules and spermatogenesis in male rats at high doses.[8] Long-term exposure to cypermethrin during adulthood is found to induce dopaminergic neurodegeneration in rats, and postnatal exposure enhances the susceptibility of animals to dopaminergic neurodegeneration if rechallenged during adulthood.[9] If exposed to cypermethrin during pregnancy, rats give birth to ...
Biosynthesis of mevastatin is primarily accomplished via a type 1 PKS pathway it proceeds in the PKS pathway as seen in figure 1 until it reaches a hexaketide state where it undergoes a Diels-Alder cyclization. After cyclization it continues via the PKS pathway to a nonaketide after which it is released and undergoes oxidation and dehydration. It is presumed that the oxidations are preformed by a polypeptide that is similar to cytochrome p450 monooxygenase, which is encoded by mlcC within the mevastatin gene. Lastly the biosynthesis is completed by the PKS facilitating the addition of a diketide sidechain and a methylation by SAM.[7] Figure 1 shows mevastatin in its acid form but it can also be in the more commonly seen lactone form. This pathway was first observed in Penicillium cilrinum and was later discovered that another type of fungus, Penicillium brevicompaetum also produced mevastatin via a PKS pathway. ...
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...
It is commonly available without a prescription in various dosage forms, such as a topical cream, ointment, or vaginal suppository. It is also available as an oral troche or throat lozenge as a prescription only. Topically, clotrimazole is used for vulvovaginal candidiasis (yeast infection) or yeast infections of the skin. For vulvovaginal candidiasis (yeast infection), clotrimazole tablets and creams are inserted into the vagina. Topical clotrimazole is usually not effective in treatment of fungal infections of the scalp or nails.[citation needed] When using over-the-counter drug clotrimazole products, use should be discontinued if condition does not improve after treatment for 2 weeks for jock itch or after 4 weeks for athlete's foot or ringworm.[6] Throat lozenge preparations are used for oropharyngeal candidiasis (oral thrush) or prevention of oral thrush in people with neutropenia.[6] Clotrimazole is usually used 5 times daily for 14 days for oral thrush, twice daily for 2 to 8 weeks for ...
... (5α-DHP), also known as allopregnanedione,[1] as well as 5α-pregnane-3,20-dione, is an endogenous progestogen and neurosteroid that is synthesized from progesterone.[2][3] It is also an intermediate in the synthesis of allopregnanolone and isopregnanolone from progesterone. 5α-DHP is an agonist of the progesterone receptor and a positive allosteric modulator of the GABAA receptor (albeit with an affinity for this receptor that is regarded as relatively low (in comparison to 3α-hydroxylated progesterone metabolites such as allopregnanolone and pregnanolone)).[2][3][4][5] It has also been found to act as a negative allosteric modulator of the GABAA-rho receptor.[6] In addition, it is a weak agonist of the pregnane X receptor (PXR) (EC50 ,10,000 µM)), with approximately six-fold lower potency relative to its 5β-isomer, 5β-dihydroprogesterone.[7]. ...
... has a potential for drug interactions; caution should be used in combining other medicines with it, including other antiepileptics and mood stabilizers.[12] Lower levels of carbamazepine are seen when administrated with phenobarbital, phenytoin, or primidone, which can result in breakthrough seizure activity. Carbamazepine, as a CYP450 inducer, may increase clearance of many drugs, decreasing their concentration in the blood to subtherapeutic levels and reducing their desired effects.[19] Drugs that are more rapidly metabolized with carbamazepine include warfarin, lamotrigine, phenytoin, theophylline, and valproic acid.[12] Drugs that decrease the metabolism of carbamazepine or otherwise increase its levels include erythromycin,[20] cimetidine, propoxyphene, and calcium channel blockers.[12] Carbamazepine also increases the metabolism of the hormones in birth control pills and can reduce their effectiveness, potentially leading to unexpected pregnancies.[12] As a drug that induces ...
... (Gewodin, Gewolen) is a nonsteroidal anti-inflammatory agent (NSAID) of the pyrazolone series which is available over-the-counter in some countries such as Taiwan.[1][2][3] It has analgesic, anti-inflammatory, and antipyretic effects.[1][2] Famprofazone has been known to produce methamphetamine as an active metabolite, with 15-20% of an oral dose being converted to it.[4][5] As a result, famprofazone has occasionally been implicated in causing positives on drug tests for amphetamines.[3] ...
... is considered a prohormone in the formation of dehydroepiandrosterone (DHEA), itself a prohormone of the sex steroids. This conversion is mediated by the enzyme 17,20 lyase. As such 17α-hydroxypregenolone represents an intermediary in the Δ5 pathway that leads from pregnenolone to DHEA. 17α-Hydroxypregneolone is also converted to 17α-hydroxyprogesterone, a prohormone for glucocorticosteroids and androstenedione through the activity of 3α-hydroxysteroid dehydrogenase. ...
... is available as a generic medication and usually not too expensive.[7] Wholesale it costs between US$0.003 and US$0.15 per dose.[8] A month of treatment is about US$30 in the United States.[2] Since September 2012, the marketing licence in the UK has been held by Flynn Pharma Ltd, of Dublin, Ireland, and the product, although identical, has been called Phenytoin Sodium xxmg Flynn Hard Capsules. (The xxmg in the name refers to the strength-for example "Phenytoin sodium 25 mg Flynn Hard Capsules").[49] The capsules are still made by Pfizer's Goedecke subsidiary's plant in Freiburg, Germany and they still have Epanutin printed on them.[50] After Pfizer's sale of the UK marketing licence to Flynn Pharma, the price of a 28-pack of 25 mg phenytoin sodium capsules marked Epanutin rose from 66p (about $0.88) to £15.74 (about $25.06). Capsules of other strengths also went up in price by the same factor-2384%,[51] costing the UK's National Health Service an extra £43 million (about $68.44 ...
Read the side effects of Cephradine as described in the medical literature. In case of any doubt consult your doctor or ... Side effect(s) of Cephradine Read the side effects of Cephradine as described in the medical literature. In case of any doubt ... Cephradine - Information. Cephradine is a first generation cephalosporin antibiotic, prescribed for certain types of bacterial ...
Find information on Cephradine (Velosef) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... cephradine is a topic covered in the Daviss Drug Guide. To view the entire topic, please log in or purchase a subscription. ... "Cephradine." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2020. Washington Manual, www.unboundmedicine.com/ ... washingtonmanual/view/Davis-Drug-Guide/109032/all/cephradine. Vallerand AHA, Sanoski CAC, Quiring CC. Cephradine. Daviss Drug ...
is recalling Cephradine Capsules because of Subpotency (stability).. PRODUCT. Cephradine Capsules USP, 250 mg in bottles of 100 ... Teva Pharmaceuticals Recalls Cephradine Capsules. Sellersville, PA (SafetyAlerts) - The Food and Drug Administration (FDA) ...
Cephradine (Eskacef - SKF; Velosef - Squibb) is a new semi-synthetic cephalosporin for oral use. Like other cephalosporins it ... 2 and the promotional literature on cephradine makes no direct comparison between the two drugs. ...
The generic ingredient in VELOSEF is cephradine. There are ten drug master file entries for this compound. Additional details ...
Prophylactic use of cephradine in dental procedures: A observational study in Bangladesh * Chowdhury Moin Jan Professor and ... Cephradine 500 mg for 5 days course was preferred as prophylactic antibiotic in dental procedures in this study. Majority of ... Cephradine therapy was mostly not associated with adverse events in patients; however, diarrhea, stomach upset and dizziness ... Keywords: dental treatment, antibiotic prophylaxis, cephradine Abstract. Bacteremia is common with manipulation of the teeth ...
cephradine ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ...
Effects of test conditions on the susceptibility of staphylococci in vitro to cephradine, cephaloridine, cephalexin, and ... Effects of test conditions on the susceptibility of staphylococci in vitro to cephradine, cephaloridine, cephalexin, and ... Methicillin-resistant staphylococci were tested for susceptibility to cephradine, cephaloridine, cephalexin, and cefuroxime and ... A similar trend was found in the case of cephradine, where it was accentuated by osmotic support. While almost all strains of ...
Find information on Cephradine (Velosef) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... cephradine is a topic covered in the Daviss Drug Guide. To view the entire topic, please sign in or purchase a subscription. ... "Cephradine." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2020. Emergency Central, emergency.unboundmedicine.com/emergency ... Davis-Drug-Guide/109032/all/cephradine. Quiring C, Sanoski CA, Vallerand AH. Cephradine. Daviss Drug Guide. F.A. Davis Company ...
Cephradine Market Research Report 2019-2025 having 118.00 pages and available at USD 3,280.00 from MarketResearchReports.com ... Figure Cephradine Value Chain. Table Cephradine Distributors List. Table Cephradine Customers List. Table Porters Five Forces ... Figure Cephradine Product Picture. Table Cephradine Key Market Segments. Table Major Manufacturers Cephradine Covered in This ... 2.1.1 Global Cephradine Production Value 2014-2025. 2.1.2 Global Cephradine Production 2014-2025. 2.1.3 Global Cephradine ...
Cephradine capsules. What are cephradine capsules?. CEPHRADINE (Anspor®, Velosef®) is a cephalosporin antibiotic. It treats ... Cephradine oral suspension. What is cephradine oral suspension?. CEPHRADINE (Anspor®, Velosef®) is a cephalosporin antibiotic. ... Generic cephradine capsules are available.. What should my health care professional know before I take cephradine?. They need ... Generic cephradine oral suspension is available.. What should my health care professional know before I take cephradine?. They ...
Cephradine is an oral first-generation cephalosporin antibiotic similar in structure and activity to cephalexin. The in vitro ... Cephradine Brand Name- Velosef What is Cephradine. Cephradine is an oral first-generation cephalosporin antibiotic similar in ... Cephradine is indicated for the treatment of urinary tract infections, skin and skin structure infections, respiratory tract ... Cephradine has been administered parenterally, however, the parenteral product is no longer available in the United States. ...
VELOSEF (Cephradine). *Cephradine is an effective antibiotic and is responsive to both gram-positive and gram-negative bacteria ... Even though no reaction was seen in rodent mammals in their pregnancy stage; when cephradine was given to them. Still caution ... After cephradine dosage, heartburn and chest pain can be evident. But its normal. ... Several strains of Enterobacteria are pathogenic and Cephradine is not efficient against them. ...
Capsule-shape and has been identified as Cephradine 500 MG. It is supplied by Teva Pharmaceuticals USA. ... biocraft 113 (Cephradine 500 MG). Pill with imprint biocraft 113 is Green, Capsule-shape and has been identified as Cephradine ... Cephradine. Imprint. biocraft 113. Strength. 500 MG. Color. Green. Shape. Capsule-shape. Availability. Prescription only. Drug ... Cephradine is used in the treatment of bacterial infection; kidney infections; bladder infection; otitis media; pharyngitis and ...
Cephradine. Cefradine is reported as an ingredient of Supracef in the following countries:. *Bangladesh ...
... new Schiff bases were synthesized from condensation of cephradine and ceftriaxone with Terephthalaldehyde and their ... Synthesis Characterization and Antibacterial Evaluation of Cephradine and Ceftriaxone Schiff Base Copper Complexes. Author(s): ... In the present study, new Schiff bases were synthesized from condensation of cephradine and ceftriaxone with Terephthalaldehyde ...
Cephradine) is a first-generation cephalosporin antibacterial given orally and by parenteral route in the treatment of ... VOLVOCEF (Cephradine) Capsules 250mg are available in pack of 10s.. VOLVOCEF (Cephradine) Capsules 500mg are available in pack ... Cephradine is contraindicated in patients with known hypersensitivity to cephradine or to any excipient of the product. ... VOLVOCEF 125mg 5mLDry Suspension (Cephradine). VOLVOCEF (Cephradine) is a first-generation cephalosporin antibacterial given ...
Cephradine is the first generation of cephalosporin, which active against gram-positive and gram-negative bacteria. Cephradine ... Precautions: Cephradine should not be used during pregnancy and breast-feeding or impaired kidney or liver dysfunction. Consult ... Each 5ml contains 125mg Cephradine USP Symptoms URTI, LRTI, Skin and Soft Tissue Infection, Boils, Abscess, Tonsillitis, UTI, ... Each 5ml contains 250mg Cephradine USP Symptoms URTI, LRTI, Skin and Soft Tissue Infection, Boils, Abscess, Tonsillitis, UTI, ...
Cephradine/Velacef. - Adult: 0.5 gm PO q6hr. - Good diffusion from blood into CSF only with inflammation;. - 80-95 % of dose ...
... distributor and trader of CEPHRADIN Cephradine Anhydrous based in Surat, Gujarat, India ... Buy online CEPHRADIN Cephradine Anhydrous, We SAINTROY LIFESCIENCE are one of the ISO 9001:2008 Certified leading supplier, ... Cephradine Anhydrous Is the Anhydrous Form of Cephradine, a Semisynthetic, Broad-spectrum, First-generation Cephalosporin With ... Cephradine Binds to and Inactivates Penicillin-binding Proteins (Pbps) Located on the Inner Membrane of the Bacterial Cell Wall ...
CEPHRADINE , SQ 11436 , SK&F D-39304 , CEFRADINE , SQ 22022 [DIHYDRATE] , ANSPOR , SQ-22022 , NICEF , VELOSEF 125 , VELOSEF ... CEPHRADINE. ChEMBL Synonyms Ecosporina , VELOSEF 250 , VELOSEF , CEPHRADINE , SQ 11436 , SK&F D-39304 , CEFRADINE , SQ 22022 ... Cefradine , VELOSEF , ANSPOR , NICEF , VELOSEF 125 , VELOSEF 500 , CEPHRADINE , Ecosporina , VELOSEF 250. ... CEPHRADINE , Ecosporina , VELOSEF 250, Synonyms:Ecosporina , VELOSEF 250 , VELOSEF , ...
Cephradine capsule should be kept below 30° C. Cephradine dry powder for suspension should be kept below 25° C & powder vial ... Amfrad Capsule contains Cephradine. Amfrad uses:. (Cefradine) is indicated for the treatment of the following infections when ... The reconstituted Cephradine injection solution should be used within 2 hours of preparation if kept at room temperature or ... The Cephradine solution should be protected from bright or direct sunlight. All strengths of reconstituted products should be ...
Specifications cephradine 1.Our products are sold to Europe and America 2.purity: 99% 3.packing: 25kg/drum 4.delivery: 3-5 days ...
cephradine capsule. On Label. RX. 0 Reviews. Principen capsule. On Label. RX. 0 Reviews. ...
cephradine capsule. On Label. RX. 0 Reviews. cefoxitin Solution, Reconstituted (Recon Soln). On Label. RX. 0 Reviews. ...
Cephalexin, cephradine, amoxicillin. 2 gm PO 1 hour prior to procedure. Discontinued within 24 hours of the procedure. For most ...
Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests. Check with your doctor immediately if you have diarrhea, fever, or any symptoms of an infection. This medicine may cause skin necrosis or gangrene. Call your doctor right away if you have pain, a color change, or a temperature change to any area of your body. Call your doctor right away if you have pain in your toes and they look purple or dark in color. These could be signs of a serious medical problem. Calciphylaxis or calcium uremic arteriolopathy may occur in patients with or without end-stage kidney disease. Tell your doctor right away if you have purplish red, net-like, blotchy spots on the skin. This medicine may increase your chance of bleeding. Check with your doctor right away if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your ...
Cephradine] [Chlorambucil] *Chloramphenicol *Chlordiazepoxide *Chlormezanone Chloroform *Chlorpropamide Cinnarizine Clemastine ...
  • Effects of test conditions on the susceptibility of staphylococci in vitro to cephradine, cephaloridine, cephalexin, and cefuroxime. (bmj.com)
  • Methicillin-resistant staphylococci were tested for susceptibility to cephradine, cephaloridine, cephalexin, and cefuroxime and 30 degree C and 37 degree C on ordinary media and on media of enhanced osmotic strength. (bmj.com)
  • When Staphylococcus aureus was tested against cephalexin and cefuroxime, most were susceptible at 37 degree C whereas all were resistant at 30 degree C. A similar trend was found in the case of cephradine, where it was accentuated by osmotic support. (bmj.com)
  • Cephradine is an oral first-generation cephalosporin antibiotic similar in structure and activity to cephalexin. (seekhealthz.com)
  • Most commonly prescribed cephalosporins: include cefadroxil, cephalexin, cephazolin and cephradine. (sooperarticles.com)
  • To compare the efficacy, safety and cost of cefuroxime and cephradine in the treatment of acute pyelonephritis in pregnancy. (scielo.cl)
  • Hospitalized women with 12 to 34 weeks of pregnancy, with clinical and bacteriological diagnosis of acute pyelonephritis, were randomly assigned to receive cefuroxime (Curocef (r), GlaxoWellcome) 750 mg t.i.d, i.v or cephradine 1 g q.i.d., i.v. If the isolated organism was resistant to the assigned drug the patient was excluded. (scielo.cl)
  • One hundred and one patients were randomized: 49 to receive cephradine and 52 to receive cefuroxime. (scielo.cl)
  • The rate of resistance of isolated uropathogens was l4% to cephradine and 1% to cefuroxime. (scielo.cl)
  • Keflex - Lilly), 2 and the promotional literature on cephradine makes no direct comparison between the two drugs. (bmj.com)
  • 2016 (90.9%) of the patients received cephradine as prophylactic antibiotic with a mean dosage of 500mg (487.48+60.99) and duration of treatment was 3-7 days (5.47+1.03). (banglajol.info)
  • The majority of the patients (1657, 82.2%) who had prophylaxis with cephradine had no clinical sign of infection and some of the patients needed to change their initial dose or change of the antibiotic. (banglajol.info)
  • Cephradine 500 mg for 5 days course was preferred as prophylactic antibiotic in dental procedures in this study. (banglajol.info)
  • Cephradine is an effective antibiotic and is responsive to both gram-positive and gram-negative bacteria. (blogspot.com)
  • Cefradine (INN) or cephradine (BAN) is a first generation cephalosporin antibiotic. (wikipedia.org)
  • Cephradine is a broad spectrum, bactericidal antibiotic active against both Gram positive and Gram negative bacteria. (intekom.com)
  • SKC sold only two cephalosporins-Ancef and Anspor (cephradine). (wikipedia.org)
  • The current study focuses on assessing the in-vitro antimicrobial activity of 24 brands of Cephradine 500mg capsules against 4 different strains by employing standardized methods . (bvsalud.org)
  • The in vitro antibacterial activity of cephradine includes excellent gram-positive but limited gram-negative coverage. (seekhealthz.com)
  • Cephradine Anhydrous Is the Anhydrous Form of Cephradine, a Semisynthetic, Broad-spectrum, First-generation Cephalosporin With Antibacterial Activity. (saintroylifescience.com)
  • Results indicated that both Cephradine and Cefotaxime has excellent in-vitro antibacterial activity, but Cefotaxime had relatively broad spectrum of activity against most of clinical isolates tested its mean that Cefotaxime is more effective against Gram-positive and Gram-negative bacteria . (bvsalud.org)
  • Sellersville, PA ( SafetyAlerts ) - The Food and Drug Administration (FDA) today reported that Teva Pharmaceuticals, USA, Inc. is recalling Cephradine Capsules because of Subpotency (stability). (safetyalerts.com)
  • Cephradine Capsules USP, 250 mg in bottles of 100, Rx indicated in the treatment of respiratory tract infection, otitis media, skin and skin-structure infections, and urinary tract infections. (safetyalerts.com)
  • What are cephradine capsules? (yourcareeverywhere.com)
  • Generic cephradine capsules are available. (yourcareeverywhere.com)
  • Take cephradine capsules by mouth. (yourcareeverywhere.com)
  • CEFRIL 250 CAPSULES and CEFRIL 500 CAPSULES contain 250 mg and 500 mg cephradine respectively. (intekom.com)
  • CEFRIL products contain Cephradine which is a semi-synthetic cephalosporin chemically designated as 7-[D-2-amino-2-(1,4-cychlohexadien-1-yl) acetamido]-3-methyl-8-oxo- 5- thia-1- azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid. (intekom.com)
  • Bacteriology studies to determine the causative organisms and their sensitivity to cephradine should be performed. (intekom.com)
  • VOLVOCEF (Cephradine) is a first-generation cephalosporin antibacterial given orally and by parenteral route in the treatment of susceptible infections and in the prophylaxis of infections during surgical procedures. (amrospharma.com)
  • Cephradine is indicated for the treatment of urinary tract infections, skin and skin structure infections, respiratory tract infections, and otitis media. (seekhealthz.com)
  • After 48 hours administration of 100 mg/kg/day of cephradine for the treatment of otitis media, cephradine has been measured in the middle ear exudate at an average level of 3,6 micrograms/mL. (intekom.com)
  • Cephradine is the first generation of cephalosporin, which active against gram-positive and gram-negative bacteria. (doctorraees.com)
  • After cephradine dosage, heartburn and chest pain can be evident. (blogspot.com)
  • Amfrad Capsule contains Cephradine. (bissoy.com)
  • Amfrad Capsule contains Cephradine 500 mg. (bissoy.com)
  • Cephradine should not be used during pregnancy and breast-feeding or impaired kidney or liver dysfunction. (doctorraees.com)
  • Generic cephradine oral suspension is available. (yourcareeverywhere.com)
  • Take cephradine oral suspension by mouth. (yourcareeverywhere.com)
  • CEFRIL 125 SUSPENSION and CEFRIL 250 SUSPENSION provide 125 mg and 250 mg cephradine per 5 mL respectively after reconstitution to 100 mL of suspension. (intekom.com)
  • Cephradine Binds to and Inactivates Penicillin-binding Proteins (Pbps) Located on the Inner Membrane of the Bacterial Cell Wall. (saintroylifescience.com)
  • Global (United States, European Union and China) Cephradine Market Research Report 2019-2025 report is published on June 20, 2019 and has 118 pages in it. (marketresearchreports.com)
  • In this report, 2018 has been considered as the base year and 2019 to 2025 as the forecast period to estimate the market size for Cephradine. (marketresearchreports.com)
  • Several strains of Enterobacteria are pathogenic and Cephradine is not efficient against them. (blogspot.com)
  • Because cephradine is unaffected by penicillinase, many strains of E. coli and Staphylococcus aureus that produce this enzyme are susceptible to cephradine. (intekom.com)
  • Chemically, cephradine is (6R,7R)-7-[(R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido] -3- methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. (amrospharma.com)
  • Standard disk of 5 micro g Cephradine powder were used during evaluation. (bvsalud.org)
  • Methicillin-resistant staphylococci are not sensitive to cephradine. (intekom.com)
  • Cephradine is mostly being given to infections caused by bacteria. (doctorraees.com)
  • Cephradine is rapidly and almost completely absorbed from the gastrointestinal tract after oral doses. (amrospharma.com)
  • Cephradine is acid stable and is rapidly absorbed following oral administration in the fasting state. (intekom.com)
  • Cephradine has been administered parenterally, however, the parenteral product is no longer available in the United States. (seekhealthz.com)
  • An in vitro study of these clinical isolates were carried out by ICLS reference Disk diffusion [Kirby-Bauer] method , using Cephradine and Cefotaxime . (bvsalud.org)
  • An attempt has been made to measured the Zone if inhibition produced by Cephradine and Cefotaxime against these clinical isolates. (bvsalud.org)
  • Plasma concentration of cephradine is prolonged in patients with renal impairment. (amrospharma.com)
  • Cephradine is contra-indicated in patients with known sensitivity to the cephalosporin family of antibiotics or to any component of the formulation. (intekom.com)