Cephalosporins
Cefamandole
Cephapirin
Phlebitis
Cefazolin
Microbial Sensitivity Tests
Cephalexin
Ambroxol
Penicillin G
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
Proteus
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in the intestines of humans and a wide variety of animals, as well as in manure, soil, and polluted waters. Its species are pathogenic, causing urinary tract infections and are also considered secondary invaders, causing septic lesions at other sites of the body.
Enterobacteriaceae
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Penicillins
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Staphylococcus
A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.
Bacteria
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Methicillin
Drug Resistance, Microbial
Ampicillin
Gentamicins
beta-Lactamases
Carbenicillin
Enterobacter aerogenes
beta-Lactams
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
Klebsiella
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.
Enterobacter
Sarcina
Bronchopneumonia
Proteus vulgaris
Amikacin
Clavulanic Acids
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Moxalactam
Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.
Kanamycin
Cefonicid
Penicillin V
Dictionaries as Topic
Sodium
pKa calculations for class A beta-lactamases: influence of substrate binding. (1/313)
Beta-Lactamases are responsible for bacterial resistance to beta-lactams and are thus of major clinical importance. However, the identity of the general base involved in their mechanism of action is still unclear. Two candidate residues, Glu166 and Lys73, have been proposed to fulfill this role. Previous studies support the proposal that Glu166 acts during the deacylation, but there is no consensus on the possible role of this residue in the acylation step. Recent experimental data and theoretical considerations indicate that Lys73 is protonated in the free beta-lactamases, showing that this residue is unlikely to act as a proton abstractor. On the other hand, it has been proposed that the pKa of Lys73 would be dramatically reduced upon substrate binding and would thus be able to act as a base. To check this hypothesis, we performed continuum electrostatic calculations for five wild-type and three beta-lactamase mutants to estimate the pKa of Lys73 in the presence of substrates, both in the Henri-Michaelis complex and in the tetrahedral intermediate. In all cases, the pKa of Lys73 was computed to be above 10, showing that it is unlikely to act as a proton abstractor, even when a beta-lactam substrate is bound in the enzyme active site. The pKa of Lys234 is also raised in the tetrahedral intermediate, thus confirming a probable role of this residue in the stabilization of the tetrahedral intermediate. The influence of the beta-lactam carboxylate on the pKa values of the active-site lysines is also discussed. (+info)Antibiotic synergy and antagonism against clinical isolates of Klebsiella species. (2/313)
Minimal inhibitory concentrations of kanamycin, gentamicin, amikacin, cephalothin, and chloramphenicol were determined in Trypticase soy broth for 70 clinical isolates of Klebsiella species. Gentamicin and amikacin were the most active on a weight basis. Chloramphenicol was more active than kanamycin, and cephalothin was the least active of all. Studies using a microtiter modification of the checkerboard technique were performed to evaluate the comparative activity of the three aminoglycosides in combination with either chloramphenicol or cephalothin. The cephalothin-aminoglycoside combinations demonstrated synergy in >80% of the isolates tested. No antagonism was noted. The chloramphenicol-aminoglycoside combinations showed antagonism in 35 to 45% of the isolates tested. The data suggest that the chloramphenicol-aminoglycoside combinations be used with caution when treating serious infections where Klebsiella is a potential pathogen. (+info)Transferability of cephalothin to the alveolar cavity in thoroughbreds. (3/313)
Five Thoroughbreds were classified into 4 groups according to the administration method used for saline solution (saline), ambroxol, and cephalothin sodium (cephalothin). In group A, cephalothin was injected intravenously after oral administration of ambroxol. In group B, cephalothin was injected intravenously after oral administration of saline. Groups C and D were used as control groups. The dose of cephalothin or ambroxol was clinically administrated. Venous blood and bronchoalveolar lavage fluid (BALF) were sampled from each group. In groups A and B, cephalothin concentrations in plasma reached their maximum level 5 min after cephalothin administration and then declined over time. In plasma obtained from groups A and B, there were no significant differences in pharmacokinetic parameters (T1/2, Kel, Vd). By contrast, cephalothin concentrations in BALF reached their peak at 180 min after cephalothin administration in both groups A and B and maintained a relatively high level even after 300 min. These findings indicate that cephalothin requires a relatively long period of time to move from the blood stream to the alveolar cavity, but once transferred to the alveolar cavity, it is preserved for a long time. In groups A and B, cephalothin concentrations in BALF were approximately at the same level. However, in group A, total protein in BALF was lower at 60, 180, and 300 min than the other groups. Then, cephalothin concentration was adjusted to total protein in BALF. After adjustment to total protein in BALF, group A showed a concentration level of cephalothin approximately 1.5-fold higher than that of group B. This suggests that the transferability of cephalothin to the alveolar cavity improves as a result of the oral administration of ambroxol. (+info)Alteration of methotrexate uptake in human leukemia cells by other agents. (4/313)
The uptake of methotrexate (MTX) and the effect of drugs known to either inhibit or enhance MTX transport in L1210 murine leukemia were studied in man using blast cells from patients with acute myelogenous leukemia in vitro. MTX uptake was found to proceed slowly, requiring at least 160 min for cells to reach a "steady state" when extracellular MTX concentrations were 1 muM. Efflux of MTX from preloaded cells required 80 to 120 min and the nonexchangeable or tightly bound fraction was 40% of the total intracellular drug. Utilizing doses that are estimates of achievable peak blood levels following single i.v. injection, cephalothin (21 mug/ml) and hydrocortisone (20 mug/ml) inhibited net MTX accumulation by 20 and 28%, respectively. Vincristine sulfate at 8.3 and 0.083 mug/ml enhanced MTX uptake by 54 and 33%, respectively, by inhibiting MTX efflux, thus increasing the level of intracellular drug in excess of the tightly bound fraction. The potential clinical implications of using MTX in combination with the aforementioned drugs for cancer chemotherapy are discussed. (+info)The exocellular DD-carboxypeptidase-endopeptidase of Streptomyces albus G. Interaction with beta-lactam antibiotics. (5/313)
Kinetically, the three-step model proposed for the interaction between beta-lactam antibiotics and the exocellular DD-carboxypeptidases-transpeptidases of Streptomyces R61 and Actinomadura R39 [Frere, Ghuysen & Iwatsubo (1975) Eur. J. Biochem. 57, 343--357; Fuad, Frere, Ghuysen, Duez & Iwatsubo (1976) Biochem. J. 155, 623--629] applies to the interaction between the much less penicillin-sensitive exocellular DD-carboxypeptidase-endopeptidase of Streptomyces albus G and at least phenoxymethylpenicillin, cephalothin and cephalosporin C. The penicillin resistance of the albus G enzyme is mainly due to the low efficiency with which the first reversible complex formed with the antibiotic (complex EI) undergoes transformation into a second more stable complex EI*. Analysis of the ternary interaction between enzyme, NalphaNepsilon-diacetyl-L-lysyl-D-alanyl-D-alanine (Ac2-L-Lys-D-Ala-D-Ala) and cephalosporin C indicates a non-competitive mechanism. (+info)Interpretive criteria for cefamandole and cephalothin disk diffusion susceptibility tests. (6/313)
A multi-center study of 1,838 clinical isolates established the accuracy of diffusion susceptibility tests with 30-mug cephalothin disks and 30-mug cefamandole disks. The same interpretive zone standards can be applied to tests with either disk but the two drugs cannot be tested interchangeably. (+info)Helicobacter mesocricetorum sp. nov., A novel Helicobacter isolated from the feces of Syrian hamsters. (7/313)
A spiral-shaped bacterium with bipolar, single, nonsheathed flagella was isolated from the feces of Syrian hamsters. The bacterium grew as a thin spreading film at 37 degrees C under microaerobic conditions, did not hydrolyze urea, was positive for catalase and alkaline phosphatase, reduced nitrate to nitrite, did not hydrolyze hippurate, and was sensitive to nalidixic acid but resistant to cephalothin. Sequence analysis of the 16S rRNA gene and biochemical and phenotypic criteria indicate that the novel bacterium is a helicobacter. The novel bacterium is most closely related to the recently described mouse enteric helicobacter, Helicobacter rodentium. This is the first urease-negative Helicobacter species with nonsheathed flagella isolated from feces of asymptomatic Syrian hamsters. We propose to name this novel helicobacter Helicobacter mesocricetorum. The type strain is MU 97-1514 (GenBank accession number AF072471). (+info)Massive pulmonary gangrene: a severe complication of Klebsiella pneumonia. (8/313)
SUMMARY: Massive pulmonary gangrene developed in two patients. Review of the literature reveals 10 other case reports of pulmonary gangrene complicating lobar pneumonia. Among the total of 12 patients whose cases have now been reported, all 4 patients who were treated nonsurgically died and the 8 who underwent surgical resection of the gangrenous lung survived. The present report emphasizes the necessity of early recognition and appropriate surgical treatment for a successful outcome. (+info)
Cephalothin synonyms, cephalothin antonyms - FreeThesaurus.com
Cephalothin
Cephalothin (Keflin) for Chickens and Ducks
CEFALOTIN 1,0 BIOTIKA | Biotika.sk
RCSB PDB - 4KOX: Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with Cefalotin
治療照護 - 衛生福利部疾病管制署
cephalothin
ARMProgram.com Trend Top Navigation
ARMProgram.com Trend Top Navigation
Cephalothin sodium | definition of cephalothin sodium by Medical dictionary
Chemoprophylaxis in cardiac and orthopedic surgery: Comparison of cephalothin and cephapirin<...
Cephalothin sodium / cephalothin sodium NDA 062464 international drug patent coverage, generic alternatives and suppliers
Truform Lymphedema Compression Gauntlet: 20-30 mmHg, Small (3322BL-S) | Staples
Crystallization of cephalothin sodium during lyophilization from tert-butyl alcohol-water cosolvent system<...
Reversible Acute Renal Failure After Cephalothin | Annals of Internal Medicine | American College of Physicians
Listeria Meningitis During Cefazolin Therapy | Annals of Internal Medicine | American College of Physicians
Anaphylactic Reaction to Cephalothin during Anesthesia | Anesthesiology | ASA Publications
Rolitetracycline | Harvard Catalyst Profiles | Harvard Catalyst
Keflex without a prescription, Janumet Xr 50/1000 Coupon www.pterodactilo.com
5 Essential Facts About Phlebitis | The VeinCare Centre
RCSB PDB
for 1IYQ
What is risk of reaction if allergic to pcn and taking cephalosporin antibiotic? - Answered by top doctors on HealthTap
What is Phlebitis? (with pictures)
Phlebitis - Pictures, Causes, Symptoms, Treatment
Rolitetracycline | Bacterial Inhibitor | MedChemExpress
Cefuroxime Axetil (Cephalosporin Antibiotic) - Medication Videos - MyRx.tv
The Coming Crisis: Sino-German research finds new E. Coli bacteria resistant to 8 classes of antibiotics - 4th June 2011
Cefamandole (Cefamandole Nafate) Panpharma
Superficial phlebitis
Cefamandole (Mandol) | Daviss Drug Guide
Cefamandole (Mandol) | Daviss Drug Guide
Parabolic Drugs in News - Parabolic Drugs
Wiekvoet: Cefamandole: PK after IV with six subjects in JAGS
Susceptibility of Anaerobic Bacteria to Cefoxitin and Related...
Septic phlebitis | definition of septic phlebitis by Medical dictionary
Experiences with three cephalosporin antibiotics in respiratory system infections. - Semantic Scholar
Today cephapirin sodium for lactating cows - G&DFarms
Antibiotics - Alexcef (Brand name: cephalexin) Buy Cheap online Price: 0.81 - Antibiotics, Cephalexin is a cephalosporin...
R: Pharmacokinetics of Cefamandole
Cephalexin 500mg (10544-013) - Medication Videos - MyRx.tv
Itchy blood - Doctor answers
Nursing Central | phlebitis
Buy Cefoprox (Cefpodoxime) Online
ဆေးထိုးရန်အတွက် Cefepime, China ဆေးထိုးရန်အတွက် Cefepime ထုတ်လုပ်သူများ, ပေးသွင်းသူများ, စက်ရုံ - NINGBO FEIYUE TRADING CO.LTD
Cefradine
Generic for Omnicef 300 mg Order Online at InternationalDrugMart
CeFAZolin (Professional Patient Advice) - Drugs.com
Astral : Products
PDB 1ceg
Buy cephalexin online, 0.81$ for pill | Cheap cephalexin
Thermodynamically controlled synthesis of cefamandole<...
Phlebitis Treatment - Book Doctor Appointments
Cefotaxime injection
Buy Suprax Online
Buy Suprax Online
Cephaloridine
However, it binds to proteins to a much lesser extent than cephalothin. Because it is also poorly absorbed after oral ... In 1962, cephalothin and cephaloridine were introduced. Cephaloridine was briefly popular because it tolerated intramuscularly ... including the nearly nontoxic cephalothin. Cephaloridine is a cephalosporin compound with pyridinium-1-ylmethyl and 2- ... and attained higher and more sustained levels in blood than cephalothin. ...
Cefoxitin
"Susceptibility of clinical isolates of bacteria to cefoxitin and cephalothin". Antimicrobial Agents and Chemotherapy. 6 (3): ...
Helicobacter bilis
It is resistant to cephalothin and nalidixic acid, but sensitive to metronidazole. Like Helicobacter hepaticus, it colonizes ...
Helicobacter cetorum
The isolated samples were resistant to nalidixic acid but sensitive to cephalothin. H. cetorum strains have been isolated in ...
Blastopirellula marina
It's "resistant to ampicillin, penicillin, cephalothin, streptomycin, and cycloserine, but not tetracycline." Six strains have ...
Cedecea
Both Cedecea and Serratia are lipase positive and resistant to colistin and cephalothin; however, Cedecea is unable to ... Cedecea strains are resistant to the following antimicrobial agents: cephalothin, extended spectrium cephalosporins, colistin, ...
Antimicrobial surface
Other antibiotics with broad antibacterial spectra are cephalothin, carbenicillin, amoxicillin, cefamandol, tobramycin, and ...
Cefalotin
... (INN) /ˌsɛfəˈloʊtɪn/ or cephalothin (USAN) /ˌsɛfəˈloʊθɪn/ is a first-generation cephalosporin antibiotic. It was the ...
SmithKline Corp. v. Eli Lilly & Co.
In 1964 Lilly introduced the first cephalosporin antibiotic, Keflin (cephalothin), into the United States market. It ...
Campylobacter hyointestinalis
It is able to grow at 25 °C, is sensitive to cephalothin, and resistant to nalidixic acid. Gebhart CJ, Ward GE, Chang K, Kurtz ...
Streptococcus canis
From this study, the bacteria were found to be sensitive to cephalothin and partially resistant to penicillin. The occurrence ...
Dicloxacillin
"In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin- ...
Septic abortion
... cephalothin plus kanamycin. And only one research found that tetracycline is more effective to decrease the time of fever than ...
Discovery and development of cephalosporins
Cephalothin, a first generation cephalosporin for parenteral use was the first cephalosporin to become available for patients ...
Cephalosporin
... cephalothin), was launched by Eli Lilly and Company in 1964.[citation needed] "cephalosporin". Merriam-Webster Dictionary. " ...
Staphylococcus nepalensis
... cephalothin, chloramphenicol, clindamycin, colistin sulphate, enrofloxacin, erythromycin, florfenicol, fosfomycin, fusidic acid ...
Campylobacter mucosalis
... strains can be distinguished from Campylobacter concisus strains by their susceptibility to cephalothin ...
List of β-lactam antibiotics
Ticarcillin Carbenicillin Ticarcillin Azlocillin Mezlocillin Piperacillin Cefazolin Cephalexin Cephalosporin C Cephalothin ...
Beta-lactamase
The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic ...
বিটা-ল্যাক্টাম অ্যান্টিবায়োটিক - উইকিপিডিয়া
সেফালোথিন (Cephalothin). *সেফাজোলিন (Cefazolin). দ্বিতীয় প্রজন্ম[সম্পাদনা]. *সেফাক্লর (Cefaclor). *সেফুরোক্সিম (Cefuroxime). * ...
cephalothin injection : Rate your experience with this treatment
Cephalothin-Induced Granulocytopenia | Annals of Internal Medicine | American College of Physicians
Cephalothin-Induced Granulocytopenia MARIO-ANTOINE DICATO, M.D.; LEONARD ELLMAN, M.D. ... Since its introduction in 1962, cephalothin (Keflin®) has assumed a major role in the therapy of bacterial infection. There ... DICATO M, ELLMAN L. Cephalothin-Induced Granulocytopenia. Ann Intern Med. 1975;83:671-672. doi: 10.7326/0003-4819-83-5-671 ... have been only sporadic reports of granulocytopenia caused by cephalothin therapy (1-3). The appearance of four such cases in a ...
Cefoxitin, a New Semi-synthetic Cephamycin: An In-vitro and In-vivo Comparison with Cephalothin | The BMJ
Cefoxitin, a New Semi-synthetic Cephamycin: An In-vitro and In-vivo Comparison with Cephalothin Br Med J 1973; 4 :653 ... Urinary recovery of cefoxitin activity was also much higher than that of cephalothin. No evidence of toxicity due to cefoxitin ... The activity of cefoxitin was compared with that of cephalothin against 229 bacterial strains. Cefoxitin was more active ... Cefoxitin, a New Semi-synthetic Cephamycin: An In-vitro and In-vivo Comparison with Cephalothin ...
Cephalothin sodium | definition of cephalothin sodium by Medical dictionary
What is cephalothin sodium? Meaning of cephalothin sodium medical term. What does cephalothin sodium mean? ... Looking for online definition of cephalothin sodium in the Medical Dictionary? cephalothin sodium explanation free. ... cephalothin sodium. cephalothin sodium. [sef′əlō′thin] a parenteral first-generation cephalosporin antibiotic. indications It ... cephalothin sodium. (sĕf′ă-lō-thĭn″) A first-generation cephalosporin antibiotic that treats infections caused by gram-positive ...
Cephaloridine and Cephalothin: Pharmacodynamics in Uremia. | Annals of Internal Medicine | American College of Physicians
Cephaloridine and Cephalothin: Pharmacodynamics in Uremia. R. L. Perkins, M.D., F.A.C.P.; E. Smith, M.D.; S. Saslaw, M.D., F.A. ... Cephalothin and Cephaloridine Therapy for Bacterial Meningitis: An Evaluation Annals of Internal Medicine; 82 (5): 689-693 ... Cephaloridine and Cephalothin: Pharmacodynamics in Uremia.. Ann Intern Med. 1968;68:1175. doi: 10.7326/0003-4819-68-5-1175_3 ... Thus, the comparative pharmacodynamics of cephalothin and cephaloridine were evaluated in a crossover study in five chronically ...
RCSB PDB
- 1KVM: X-ray Crystal Structure of AmpC WT beta-Lactamase in Complex with Covalently Bound Cephalothin...
Stability of Ranitidine Hydrochloride with Cefazolin Sodium, Cefbuperazone Sodium, Cefoxitin Sodium and Cephalothin Sodium...
... cephalothin sodium and cefbuperazone sodium) during simulated Y-site injection were studied. The mixtures were prepared by ... On the other hand, since ranitidine with cephalothin (20 mg/mL) fell below 90%, the amount of cephalothin should not exceed 10 ... except for cephalothin (86.6% of control). In the presence of 10 mg/mL cephalothin, however, ranitidine retained greater than ... Stability of Ranitidine Hydrochloride with Cefazolin Sodium, Cefbuperazone Sodium, Cefoxitin Sodium and Cephalothin Sodium ...
Cephalothin sodium / cephalothin sodium NDA 062464 international drug patent coverage, generic alternatives and suppliers
The generic ingredient in CEPHALOTHIN SODIUM is cephalothin sodium. There are seven drug master file entries for this compound ... NDA 062464 describes CEPHALOTHIN SODIUM, which is a drug marketed by Abbott, Abraxis Pharm, Bristol, and Baxter Hlthcare, and ... Additional details are available on the CEPHALOTHIN SODIUM profile page. ...
Cephalothin Sodium | elephantcare
Cephalothin Sodium Injection 1 g and 2 g in 5% dextrose premixed bags in 50 ml D5W (frozen); Cephalothin Sodium® (Baxter); (Rx) ... Cephalothin Sodium Powder for Injection 1 g, 2 g in 10 ml vials and 100 ml piggyback vials and Faspak; Keflin®, Neutral (Lilly ... The following drugs or solutions are reportedly compatible with cephalothin: D25W/Amino Acids 4.25%, D5W in Lactated Ringers, ... Uses/Indications - In the United States, there are no cephalothin products approved for veterinary species, but it has been ...
Anaphylactic Reaction to Cephalothin during Anesthesia | Anesthesiology | ASA Publications
Anaphylactic Reaction to Cephalothin during Anesthesia You will receive an email whenever this article is corrected, updated, ... Anaphylactic Reaction to Cephalothin during Anesthesia. Anesthesiology 10 1975, Vol.43, 476-478. doi: ... Jose L. Velazquez, Martin I. Gold; Anaphylactic Reaction to Cephalothin during Anesthesia. Anesthesiology 1975;43(4):476-478. ...
ION-PAIR EXTRACTION AND HIGH-SPEED LIQUID CHROMATOGRAPHY OF CEPHALOTHIN AND DEACETYLCEPHALOTHIN IN HUMAN SERUM AND URINE | Drug...
ION-PAIR EXTRACTION AND HIGH-SPEED LIQUID CHROMATOGRAPHY OF CEPHALOTHIN AND DEACETYLCEPHALOTHIN IN HUMAN SERUM AND URINE. M. J ... ION-PAIR EXTRACTION AND HIGH-SPEED LIQUID CHROMATOGRAPHY OF CEPHALOTHIN AND DEACETYLCEPHALOTHIN IN HUMAN SERUM AND URINE. M. J ... ION-PAIR EXTRACTION AND HIGH-SPEED LIQUID CHROMATOGRAPHY OF CEPHALOTHIN AND DEACETYLCEPHALOTHIN IN HUMAN SERUM AND URINE. M. J ... Cephalothin and its major metabolite, deacetylcephalothin, have been analyzed in human serum and urine using high-speed ion ...
Cephalothin | Johns Hopkins ABX Guide
Cephalothin answers are found in the Johns Hopkins ABX Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, ... Cephalothin is a topic covered in the Johns Hopkins ABX Guide. To view the entire topic, please sign in or purchase a ... "Cephalothin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/ ... view/Johns_Hopkins_ABX_Guide/540108/all/Cephalothin. Avdic E, Pham PA. Cephalothin. Johns Hopkins ABX Guide. The Johns Hopkins ...
Cephalothin
cephalothin
... sodium - [USP] the monosodium salt of cephalothin, used in the treatment of infections of the major organ and ... cephalothin - Cephalosporin Ceph a*lo*spor in (s[e^]f [.a]*l[ o]*sp[=o]r [i^]n), n. [from Cephalosporium, a fungus producing ... cephalothin. ceph·a·lo·thin (sĕfʹə-lə-thĭn) n. A semisynthetic analogue of cephalosporin having a broad spectrum of antibiotic ... cephalothin - Chemically modified cephalosporin C, a broad spectrum antibiotic. * * * ceph·a·lo·thin sef ə lə (.)thin n a ...
Nephrotoxicity Associated With Cephalothin Administration | JAMA Internal Medicine | JAMA Network
Variable degrees of acute renal failure developed in three patients receiving therapy with cephalothin sodium. The course and ... Nephrotoxicity Associated With Cephalothin Administration. Philip C. Carling, MD; Beldon A. Idelson, MD; A. Andrew Casano, MD; ... Nephrotoxicity Associated With Cephalothin Administration. Arch Intern Med. 1975;135(6):797-801. doi:10.1001/archinte. ... Variable degrees of acute renal failure developed in three patients receiving therapy with cephalothin sodium. The course and ...
Cephalothin Sodium Salt | RMI
Cephalothin | 58-71-9
You can also browse global suppliers,vendor,prices,Price,manufacturers of Cephalothin(58-71-9). At last,Cephalothin(58-71-9) ... Visit ChemicalBook To find more Cephalothin(58-71-9) information like chemical properties,Structure,melting point,boiling point ... Cephalothin. Product Name:. Cephalothin. CAS No.. 58-71-9. Chemical Name:. Cephalothin. CBNumber:. CB9443527. Molecular Formula ... Cephalothin sodium salt. Purity:. 96.0-101.0%. Packaging:. 1g. Price:. $111. Updated:. 2020/08/18. Buy:. Buy. Sigma-Aldrich ...
cephalothin sodium | Taber's Medical Dictionary
cephalothin sodium answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad ... cephalothin sodium is a topic covered in the Tabers Medical Dictionary. To view the entire topic, please log in or purchase a ... "Cephalothin Sodium." Tabers Medical Dictionary, 24th ed., F.A. Davis Company, 2021. Nursing Central Redesign, nursing. ... unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/738334/all/cephalothin_sodium. Cephalothin sodium. In: Venes DD, ed. ...
Cephalothin synonyms, cephalothin antonyms - FreeThesaurus.com
Antonyms for cephalothin. 2 words related to cephalothin: cephalosporin, Mefoxin. What are synonyms for cephalothin? ... cephalothin. Also found in: Dictionary, Medical, Encyclopedia, Wikipedia.. Related to cephalothin: cephalexin, cefazolin, ... Pharmacokinetics of cephalothin and cephalexin in selected avian species.. Successful treatment of a radioulnar synostosis in a ... Words related to cephalothin. a semisynthetic analogue of cephalosporin. Related Words. *cephalosporin ...
Cephalothin (Keflin) for Chickens and Ducks
In-vitro activity and beta-lactamase stability of methicillin, isoxazolyl penicillins and cephalothin against coagulase...
The inactivation of cephalothin differed from that of the other antibiotics. Type: Journal article Language: English Published ... flucloxacillin and cephalothin. The highest level of resistance was found to methicillin and the lowest to cephalothin. The ... In-vitro activity and beta-lactamase stability of methicillin, isoxazolyl penicillins and cephalothin against coagulase- ...
RCSB PDB
for 1IYP
Anaphylactoid Reaction to an Initial Dose of Sodium Cephalothin | JAMA | JAMA Network
CEPHALOTHIN, the sodium salt of 7-(thiophene2-acetamido) cephalosporanic acid, is a semisynthetic derivative of cephalosporin C ... Anaphylactoid Reaction to an Initial Dose of Sodium Cephalothin. Sherwin A. Kabins, MD; Bernard Eisenstein, MD; Sidney Cohen, ... CEPHALOTHIN, the sodium salt of 7-(thiophene2-acetamido) cephalosporanic acid, is a semisynthetic derivative of cephalosporin C ... Kabins SA, Eisenstein B, Cohen S. Anaphylactoid Reaction to an Initial Dose of Sodium Cephalothin. JAMA. 1965;193(2):165-166. ...
Antibiotics Tested by NARMS | NARMS | CDC
Artificial gene amplification reveals an abundance of promiscuous resistance determinants in Escherichia coli | PNAS
Cefalotin | Article about Cefalotin by The Free Dictionary
Crystallization of cephalothin sodium during lyophilization from tert-butyl alcohol-water cosolvent system<...
Crystallization of cephalothin sodium during lyophilization from tert-butyl alcohol-water cosolvent system. / Telang, Chitra; ... Crystallization of cephalothin sodium during lyophilization from tert-butyl alcohol-water cosolvent system. In: Pharmaceutical ... Because cephalothin sodium (I) does not crystallize readily when freeze-dried from aqueous solutions, organic cosolvents were ... Because cephalothin sodium (I) does not crystallize readily when freeze-dried from aqueous solutions, organic cosolvents were ...
Chemoprophylaxis in cardiac and orthopedic surgery: Comparison of cephalothin and cephapirin<...
Chemoprophylaxis in cardiac and orthopedic surgery: Comparison of cephalothin and cephapirin. Southern medical journal. 1982 ... Cephalothin and cephapirin have equivalent chemoprophylactic activity by clinical and microbiological criteria, permitting cost ... Cephalothin and cephapirin have equivalent chemoprophylactic activity by clinical and microbiological criteria, permitting cost ... Cephalothin and cephapirin have equivalent chemoprophylactic activity by clinical and microbiological criteria, permitting cost ...
BAM Chapter 7: Campylobacter | FDA
Resistance to cephalothin. R. R. R. R. S(e). S. S. a Symbols: +, 90% or more of strains are positive; -, 90% or more of strains ... e Cephalothin-resistant C. fetus subsp. fetus strains have been reported.. NOTE: C. hyointestinalis requires H2 for vigorous ... Swab an Abeyta-Hunt-Bark agar plate without antibiotics with the suspension and drop nalidixic acid and cephalothin disks onto ...
Ampicillin7
- OY15 did show apparent resistance to ampicillin (10 [micro]g) and cephalothin (30 big) on Mueller Hinton agar during sensitivity testing. (freethesaurus.com)
- Tzianabos reported similar results with different antibiotic classes including cephalothin , gentamicin and ampicillin/clavulanic acid. (freethesaurus.com)
- One hundred percent of ETEC and Shigella isolates showed resistance to ampicillin, carbenicillin and cephalothin. (scirp.org)
- The prevalence of resistance among E coli and all isolates combined was more than 20% for ampicillin, cephalothin, and sulfamethoxazole in each year studied. (nih.gov)
- While the prevalence of resistance to trimethoprim-sulfamethoxazole, ampicillin, and cephalothin increased significantly among uropathogens causing acute cystitis, resistance to nitrofurantoin and ciprofloxacin remained infrequent. (nih.gov)
- 75%] to ampicillin, cephalothin, chloramphenicol and tetracycline. (who.int)
- SEC plates showed good agreement with Mueller-Hinton II agar in MIC studies and can be used to screen and discriminate resistant E. coli for ampicillin, cephalothin, streptomycin, chloramphenicol, cefotaxime and gentamicin using CLSI standardized breakpoints, but not for sulphamethoxazole. (springer.com)
Antibiotic5
- Pharmacokinetic studies in 18 volunteers showed a higher and longer sustained antibiotic activity in serum and urine after injections of cefoxitin than after equal doses of cephalothin. (bmj.com)
- Chemistry - An injectable semi-synthetic cephalosporin antibiotic, cephalothin sodium occurs as a practically odorless, white to off-white, crystalline powder. (elephantcare.org)
- cephalothin - Chemically modified cephalosporin C, a broad spectrum antibiotic. (academic.ru)
- Cephalothin is a first-generation cephalosporin antibiotic used to study the mechanism of liposome encapsulated antibiotics,strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics,and for immunology studies in relation to antibiotics.It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis. (chemicalbook.com)
- CEPHALOTHIN, the sodium salt of 7-(thiophene2-acetamido) cephalosporanic acid, is a semisynthetic derivative of cephalosporin C, one of the naturally occurring cephalosporins, a family of antibiotics resembling the penicillins in antibiotic properties. (jamanetwork.com)
Keflin3
- Since its introduction in 1962, cephalothin (Keflin®) has assumed a major role in the therapy of bacterial infection. (annals.org)
- Cephalothin sodium (Keflin) occurs as a white to off-white,crystalline powder that is practically odorless. (chemicalbook.com)
- Cephalothin (Keflin) is a first-generation cephalosporin antiobiotic used to treat certain bacterial infections in poultry. (poultrydvm.com)
Cefazolin1
- The compatibility and stability of ranitidine hydrochloride when comixed with four cephalosporins (cefazolin sodium, cefoxitin sodium, cephalothin sodium and cefbuperazone sodium) during simulated Y-site injection were studied. (ijpc.com)
Cephapirin5
- In a retrospective sequential study we determined the rate of infection occurring despite cephalothin or cephapirin chemoprophylaxis in orthopedic and cardiac surgery done from 1973 to 1977. (elsevier.com)
- The incidence of infection after prosthetic hip placement or open reduction of hip fracture was 3.4% and 1.0% in patients receiving cephalothin or cephapirin, respectively. (elsevier.com)
- The infection rate after prosthetic heart valve implantation was 3.5% in those receiving cephalothin and 1.6% in those receiving cephapirin. (elsevier.com)
- Although cephapirin was effective at lower concentration, the activity of cephalothin and cephapirin was comparable. (elsevier.com)
- Cephalothin and cephapirin have equivalent chemoprophylactic activity by clinical and microbiological criteria, permitting cost to be used as a basis for choosing between these antibiotics. (elsevier.com)
Cefoxitin7
- The activity of cefoxitin was compared with that of cephalothin against 229 bacterial strains. (bmj.com)
- Against Gram-positive organisms, however, cefoxitin was considerably less active than cephalothin, but minimum inhibitory concentrations for Staphylococcus aureus were well within therapeutically attainable blood levels. (bmj.com)
- Urinary recovery of cefoxitin activity was also much higher than that of cephalothin. (bmj.com)
- Cefoxitin was slightly less painful after intramuscular injection than cephalothin. (bmj.com)
- One RCT comparing cefoxitin with cephalothin in 19 patients treated for chronic destructive pneumonia (8) had a thoracic surgeon as first author. (freethesaurus.com)
- A randomized, double-blind, multicenter trial was initiated to compare the safety and efficacy of piperacillin, cephalothin and cefoxitin in the prophylactic treatment of patients undergoing vaginal hysterectomy. (elsevier.com)
- A satisfactory prophylactic response was obtained in 143 of 151 (95 per cent) patients treated with piperacillin, in 82 of 87 (94 per cent) patients treated with cephalothin and in 57 of 60 (95 per cent) patients treated with cefoxitin. (elsevier.com)
Cephalosporins1
- Cephalosporins involved in these reports included cephalothin and cephaloridine. (freethesaurus.com)
Cephalexin1
- Pharmacokinetics of cephalothin and cephalexin in selected avian species. (freethesaurus.com)
Cephaloridine and Cephalothin1
- Cephaloridine and Cephalothin: Pharmacodynamics in Uremia. (annals.org)
Penicillin2
- Among the penicillin-like drugs, amoxicillin and cephalothin were the most effective in stopping bacterial growth. (freethesaurus.com)
- This hope was strengthened by the failure to observe cross-reactions after intradermal tests with cephalosporin C in penicillin-sensitive patients 1 and by the lack of reactions following administration of cephalothin to such patients. (jamanetwork.com)
19621
- In 1962, cephalothin and cephaloridine were introduced. (wikipedia.org)
Amikacin5
- In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. (biomedcentral.com)
- activity of dicloxacillin plus amikacin, cephalothin plus amikacin, cephalothin plus vancomycin, imipenem plus vancomycin and vancomycin plus amikacin was evaluated by checkerboard synergy tests and the fractional inhibitory concentration index (FIC) was calculated. (biomedcentral.com)
- Results: dicloxacillin plus amikacin, and cephalothin plus amikacin were synergistic or partially synergistic in 84.6% and 100% respectively. (biomedcentral.com)
- For nearly half of the isolates the mean concentrations of dicloxacillin, cephalothin and amikacin at which FIC indexes were calculated were achievable therapeutically. (biomedcentral.com)
- in this study the checkerboard analysis showed that amikacin in combination with cephalothin or dicloxacillin was synergistic against most of the resistant strains of S. aureus and coagulase-negative Staphylococcus . (biomedcentral.com)
Injection1
- After reconstituting with sterile water for injection, cephalothin sodium neutral is stable for 12 hours at room temperature and 96 hours when refrigerated. (elephantcare.org)
Lilly1
- Literature issued December 20, 1970 on Cephalothin Discs by Eli Lilly and Co., Indianapolis, IN. (atcc.org)
Resistant1
- Unlikeampicillin, cephalothin is resistant to penicillinase producedby S. aureus and provides an alternative to the use ofpenicillinase-resistant penicillins for the treatment of infectionscaused by such strains. (chemicalbook.com)
Resistance1
- The highest level of resistance was found to methicillin and the lowest to cephalothin. (forskningsdatabasen.dk)
Dicloxacillin1
- Forty-nine clinical strains of coagulase-negative staphylococci were investigated for susceptibility to methicillin, oxacillin, cloxacillin, dicloxacillin, flucloxacillin and cephalothin. (forskningsdatabasen.dk)
Poorly1
- Cephalothin is absorbed poorly from the GI tract andmust be administered parenterally for systemic infections. (chemicalbook.com)
Therapy3
- There have been only sporadic reports of granulocytopenia caused by cephalothin therapy (1-3). (annals.org)
- Variable degrees of acute renal failure developed in three patients receiving therapy with cephalothin sodium. (jamanetwork.com)
- No other causes for renal failure could be detected, and all recovered after discontinuation of cephalothin therapy, although peritoneal dialysis was required in one patient. (jamanetwork.com)
Oral1
- Pharmacokinetics (specific) - Cephalothin is not appreciably absorbed after oral administration and must be given parenterally to achieve therapeutic serum levels. (elephantcare.org)
Https2
- 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540108/all/Cephalothin. (hopkinsguides.com)
- 2021. https://nursing.unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/738334/all/cephalothin_sodium. (unboundmedicine.com)
Stable1
- In the frozen state, cephalothin sodium solutions are relatively stable. (elephantcare.org)
Patients1
- Thus, the comparative pharmacodynamics of cephalothin and cephaloridine were evaluated in a crossover study in five chronically uremic patients before and during peritoneal dialysis. (annals.org)
URINE1
- Cephalothin and its major metabolite, deacetylcephalothin, have been analyzed in human serum and urine using high-speed ion exchange liquid chromatography. (aspetjournals.org)
Antibiotics1
- The inactivation of cephalothin differed from that of the other antibiotics. (forskningsdatabasen.dk)
Species1
- Uses/Indications - In the United States, there are no cephalothin products approved for veterinary species, but it has been used clinically in several species when a relatively short-acting, injectable, first generation cephalosporin is indicated. (elephantcare.org)
Activity1
- Pharmacology/Spectrum of Activity - A first generation cephalosporin, cephalothin exhibits activity against the bacteria usually covered by this class. (elephantcare.org)