A cephalosporin antibiotic.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
A cephalosporin antibiotic.
Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate.
Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms.
Inflammation of a vein, often a vein in the leg. Phlebitis associated with a blood clot is called (THROMBOPHLEBITIS).
A semisynthetic cephamycin antibiotic resistant to beta-lactamase.
A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Analogs or derivatives of mandelic acid (alpha-hydroxybenzeneacetic acid).
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.
A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
Substances that reduce the growth or reproduction of BACTERIA.
A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in the intestines of humans and a wide variety of animals, as well as in manure, soil, and polluted waters. Its species are pathogenic, causing urinary tract infections and are also considered secondary invaders, causing septic lesions at other sites of the body.
One of the PENICILLINS which is resistant to PENICILLINASE.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.
A pyrrolidinylmethyl TETRACYCLINE.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Nonsusceptibility of an organism to the action of penicillins.
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
Gram-negative, capsulated, gas-producing rods found widely in nature. Both motile and non-motile strains exist. The species is closely related to KLEBSIELLA PNEUMONIAE and is frequently associated with nosocomial infections
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.
A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.
An antibiotic derived from penicillin similar to CARBENICILLIN in action.
Gram-negative gas-producing rods found in feces of humans and other animals, sewage, soil, water, and dairy products.
An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.
A genus of gram-positive, anaerobic bacteria whose organisms divide in three perpendicular planes and occur in packets of eight or more cells. It has been isolated from soil, grains, and clinical specimens.
Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative.
Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLES to the PULMONARY ALVEOLI. The affected areas become filled with exudate that forms consolidated patches.
Semisynthetic broad-spectrum cephalosporin.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in soil, fecal matter, and sewage. It is an opportunistic pathogen and causes cystitis and pyelonephritis.
Infections by bacteria, general or unspecified.
A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.
Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.
A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.
A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.

pKa calculations for class A beta-lactamases: influence of substrate binding. (1/313)

Beta-Lactamases are responsible for bacterial resistance to beta-lactams and are thus of major clinical importance. However, the identity of the general base involved in their mechanism of action is still unclear. Two candidate residues, Glu166 and Lys73, have been proposed to fulfill this role. Previous studies support the proposal that Glu166 acts during the deacylation, but there is no consensus on the possible role of this residue in the acylation step. Recent experimental data and theoretical considerations indicate that Lys73 is protonated in the free beta-lactamases, showing that this residue is unlikely to act as a proton abstractor. On the other hand, it has been proposed that the pKa of Lys73 would be dramatically reduced upon substrate binding and would thus be able to act as a base. To check this hypothesis, we performed continuum electrostatic calculations for five wild-type and three beta-lactamase mutants to estimate the pKa of Lys73 in the presence of substrates, both in the Henri-Michaelis complex and in the tetrahedral intermediate. In all cases, the pKa of Lys73 was computed to be above 10, showing that it is unlikely to act as a proton abstractor, even when a beta-lactam substrate is bound in the enzyme active site. The pKa of Lys234 is also raised in the tetrahedral intermediate, thus confirming a probable role of this residue in the stabilization of the tetrahedral intermediate. The influence of the beta-lactam carboxylate on the pKa values of the active-site lysines is also discussed.  (+info)

Antibiotic synergy and antagonism against clinical isolates of Klebsiella species. (2/313)

Minimal inhibitory concentrations of kanamycin, gentamicin, amikacin, cephalothin, and chloramphenicol were determined in Trypticase soy broth for 70 clinical isolates of Klebsiella species. Gentamicin and amikacin were the most active on a weight basis. Chloramphenicol was more active than kanamycin, and cephalothin was the least active of all. Studies using a microtiter modification of the checkerboard technique were performed to evaluate the comparative activity of the three aminoglycosides in combination with either chloramphenicol or cephalothin. The cephalothin-aminoglycoside combinations demonstrated synergy in >80% of the isolates tested. No antagonism was noted. The chloramphenicol-aminoglycoside combinations showed antagonism in 35 to 45% of the isolates tested. The data suggest that the chloramphenicol-aminoglycoside combinations be used with caution when treating serious infections where Klebsiella is a potential pathogen.  (+info)

Transferability of cephalothin to the alveolar cavity in thoroughbreds. (3/313)

Five Thoroughbreds were classified into 4 groups according to the administration method used for saline solution (saline), ambroxol, and cephalothin sodium (cephalothin). In group A, cephalothin was injected intravenously after oral administration of ambroxol. In group B, cephalothin was injected intravenously after oral administration of saline. Groups C and D were used as control groups. The dose of cephalothin or ambroxol was clinically administrated. Venous blood and bronchoalveolar lavage fluid (BALF) were sampled from each group. In groups A and B, cephalothin concentrations in plasma reached their maximum level 5 min after cephalothin administration and then declined over time. In plasma obtained from groups A and B, there were no significant differences in pharmacokinetic parameters (T1/2, Kel, Vd). By contrast, cephalothin concentrations in BALF reached their peak at 180 min after cephalothin administration in both groups A and B and maintained a relatively high level even after 300 min. These findings indicate that cephalothin requires a relatively long period of time to move from the blood stream to the alveolar cavity, but once transferred to the alveolar cavity, it is preserved for a long time. In groups A and B, cephalothin concentrations in BALF were approximately at the same level. However, in group A, total protein in BALF was lower at 60, 180, and 300 min than the other groups. Then, cephalothin concentration was adjusted to total protein in BALF. After adjustment to total protein in BALF, group A showed a concentration level of cephalothin approximately 1.5-fold higher than that of group B. This suggests that the transferability of cephalothin to the alveolar cavity improves as a result of the oral administration of ambroxol.  (+info)

Alteration of methotrexate uptake in human leukemia cells by other agents. (4/313)

The uptake of methotrexate (MTX) and the effect of drugs known to either inhibit or enhance MTX transport in L1210 murine leukemia were studied in man using blast cells from patients with acute myelogenous leukemia in vitro. MTX uptake was found to proceed slowly, requiring at least 160 min for cells to reach a "steady state" when extracellular MTX concentrations were 1 muM. Efflux of MTX from preloaded cells required 80 to 120 min and the nonexchangeable or tightly bound fraction was 40% of the total intracellular drug. Utilizing doses that are estimates of achievable peak blood levels following single i.v. injection, cephalothin (21 mug/ml) and hydrocortisone (20 mug/ml) inhibited net MTX accumulation by 20 and 28%, respectively. Vincristine sulfate at 8.3 and 0.083 mug/ml enhanced MTX uptake by 54 and 33%, respectively, by inhibiting MTX efflux, thus increasing the level of intracellular drug in excess of the tightly bound fraction. The potential clinical implications of using MTX in combination with the aforementioned drugs for cancer chemotherapy are discussed.  (+info)

The exocellular DD-carboxypeptidase-endopeptidase of Streptomyces albus G. Interaction with beta-lactam antibiotics. (5/313)

Kinetically, the three-step model proposed for the interaction between beta-lactam antibiotics and the exocellular DD-carboxypeptidases-transpeptidases of Streptomyces R61 and Actinomadura R39 [Frere, Ghuysen & Iwatsubo (1975) Eur. J. Biochem. 57, 343--357; Fuad, Frere, Ghuysen, Duez & Iwatsubo (1976) Biochem. J. 155, 623--629] applies to the interaction between the much less penicillin-sensitive exocellular DD-carboxypeptidase-endopeptidase of Streptomyces albus G and at least phenoxymethylpenicillin, cephalothin and cephalosporin C. The penicillin resistance of the albus G enzyme is mainly due to the low efficiency with which the first reversible complex formed with the antibiotic (complex EI) undergoes transformation into a second more stable complex EI*. Analysis of the ternary interaction between enzyme, NalphaNepsilon-diacetyl-L-lysyl-D-alanyl-D-alanine (Ac2-L-Lys-D-Ala-D-Ala) and cephalosporin C indicates a non-competitive mechanism.  (+info)

Interpretive criteria for cefamandole and cephalothin disk diffusion susceptibility tests. (6/313)

A multi-center study of 1,838 clinical isolates established the accuracy of diffusion susceptibility tests with 30-mug cephalothin disks and 30-mug cefamandole disks. The same interpretive zone standards can be applied to tests with either disk but the two drugs cannot be tested interchangeably.  (+info)

Helicobacter mesocricetorum sp. nov., A novel Helicobacter isolated from the feces of Syrian hamsters. (7/313)

A spiral-shaped bacterium with bipolar, single, nonsheathed flagella was isolated from the feces of Syrian hamsters. The bacterium grew as a thin spreading film at 37 degrees C under microaerobic conditions, did not hydrolyze urea, was positive for catalase and alkaline phosphatase, reduced nitrate to nitrite, did not hydrolyze hippurate, and was sensitive to nalidixic acid but resistant to cephalothin. Sequence analysis of the 16S rRNA gene and biochemical and phenotypic criteria indicate that the novel bacterium is a helicobacter. The novel bacterium is most closely related to the recently described mouse enteric helicobacter, Helicobacter rodentium. This is the first urease-negative Helicobacter species with nonsheathed flagella isolated from feces of asymptomatic Syrian hamsters. We propose to name this novel helicobacter Helicobacter mesocricetorum. The type strain is MU 97-1514 (GenBank accession number AF072471).  (+info)

Massive pulmonary gangrene: a severe complication of Klebsiella pneumonia. (8/313)

SUMMARY: Massive pulmonary gangrene developed in two patients. Review of the literature reveals 10 other case reports of pulmonary gangrene complicating lobar pneumonia. Among the total of 12 patients whose cases have now been reported, all 4 patients who were treated nonsurgically died and the 8 who underwent surgical resection of the gangrenous lung survived. The present report emphasizes the necessity of early recognition and appropriate surgical treatment for a successful outcome.  (+info)

Synonyms for cephalothin in Free Thesaurus. Antonyms for cephalothin. 2 words related to cephalothin: cephalosporin, Mefoxin. What are synonyms for cephalothin?
Cephalothin (Keflin) is a first-generation cephalosporin antiobiotic used to treat certain bacterial infections in poultry. It is used for treating gram-positive cocci, some gram-negative bacteria, and some anaerobes, including skin-related infections caused by Staphylococcus aureus.
Písomná informácia pre používateľov. Informácia o použití, čítajte pozorne!. CEFALOTIN 1,0 BIOTIKA. prášok na injekčný roztok. (cefalotinum natricum). Zloženie lieku. Liečivo: Cefalotinum natricum 1,058 g zodpovedá 1,0 g cefalotinum v 1 fľaštičke.. Pomocná látka: žiadna. 1 g Cefalotinu Biotikaobsahuje 2,39 mmol sodíka.. Farmakoterapeutická skupina. Antibiotikum. Charakteristika. Širokospektrálne polosyntetické antibiotikum 1. generácie cefalosporínov určené na parenterálnu aplikáciu. Rovnako ako ostatné betalaktámové antibiotiká blokuje syntézu bunkovej steny baktérií. Je odolný voči niektorým betalaktamázam. Cefalotín veľmi dobre účinkuje proti grampozitívnym kokom vrátane streptokokov skupín A,B,C,G a ďalším, tiež pneumokokov (s výnimkou kmeňov rezistentných voči penicilínu) a stafylokokov (vrátane kmeňov produkujúcich penicilinázu, ale s výnimkou kmeňov rezistentných voči meticilínu (oxacilínu)). Z gramnegatívnych ...
一般可使用penicillin, ampicillin, cephalothin 和 vancomycin等抗生素治療。對於心內膜炎或敗血症的病患可同時使用penicillin和gentamicin。如能早期診斷、及時治療並給予適當的抗生素,則有復原的機會。若延遲治療患者,可能導致的毒性休克性症候群(TSS)的發生,而有生命危險。. ...
ceph·a·lo·thin (sĕfʹə lə thĭn) n. A semisynthetic analogue of cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally and used especially to treat systemic infections caused by susceptible microorganisms. …
Drugs with less than 10 isolates are removed from the chart and from the graph. The following drugs had some data removed: gatifloxacin, penicillin, piperacillin, amoxicillin, cephalothin, cefoxitin, ofloxacin, moxifloxacin. ...
Drugs with less than 10 isolates are removed from the chart and from the graph. The following drugs had some data removed: cephalothin, moxifloxacin, clindamycin, erythromycin. ...
Looking for online definition of cephalothin sodium in the Medical Dictionary? cephalothin sodium explanation free. What is cephalothin sodium? Meaning of cephalothin sodium medical term. What does cephalothin sodium mean?
TY - JOUR. T1 - Chemoprophylaxis in cardiac and orthopedic surgery. T2 - Comparison of cephalothin and cephapirin. AU - Bryant, Richard E.. AU - Hartstein, Alan I.. AU - Starr, Albert. AU - Beals, Rodney K.. PY - 1982/9. Y1 - 1982/9. N2 - In a retrospective sequential study we determined the rate of infection occurring despite cephalothin or cephapirin chemoprophylaxis in orthopedic and cardiac surgery done from 1973 to 1977. The incidence of infection after prosthetic hip placement or open reduction of hip fracture was 3.4% and 1.0% in patients receiving cephalothin or cephapirin, respectively. The infection rate after prosthetic heart valve implantation was 3.5% in those receiving cephalothin and 1.6% in those receiving cephapirin. There was no significant difference in infection rate, duration of fever 3=38.0 C, or length of postoperative hospitalization. The efficacy of selected antistaphylococcal antibiotics in preventing colonization of human fibrin clots by staphylococci was studied. ...
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We recently treated a patient with oliguric acute renal failure after cephalothin (Keflin®) therapy.. This 48-year-old man was referred to the M. S. Hershey Medical Center because of azotemia and oliguria. Twelve days before admission he was admitted to another hospital for right renal colic. His blood urea nitrogen (BUN) was 15 mg/dl; an intravenous pyelogram showed a normal left kidney and nonvisualization of the right kidney, with several calcific densities in the area of the right kidney. Because of fever, he was given cephalothin intravenously, 16 g/day for 8 days. On the eighth day of therapy, oliguria was noted, ...
Suboptimal response of meningitis to cephalothin therapy (1-2) and actual development of meningitis during cephalothin therapy (3) have been reported. We recently observed a patient who developed meningitis due to Listeria monocytogenes while he was being treated with the new cephalosporin antibiotic, cefazolin.. A 31-year-old Egyptian man with systemic lupus erythematosus and biopsy-proved lupus nephritis of the membranoproliferative type was admitted on 16 September 1974 with nephrotic syndrome and renal failure. He was treated with high dose prednisone, intermittent peritoneal dialysis, and after 10 days of hospitalization he was started on a course of nitrogen mustard. On 22 October 1974 ...
We have emailed you at with instructions on how to set up a new password. If you do not receive an email in the next 24 hours, or if you misplace your new password, please contact:. ASA members: ...
This graph shows the total number of publications written about Rolitetracycline by people in Harvard Catalyst Profiles by year, and whether Rolitetracycline was a major or minor topic of these publication ...
Keflex or cephalexin is a medication which belongs to a vast range of medicines known as antibiotics. The generic name of Keflex is known as cephalexin, and it is branded by various big pharmaceutical firms under the brand name of Daxbia and Keflex Nov 14, 2010 · Antimicrobial Action Keflex (Cephalexin/Cefalexin) 250/500/750mg Tablets As for Cefalotin Sodium, although cefalexin is generally less potent. Keflex (cephalexin) 500 mg Tablets. The usual adult dose can range from 1 mg to 4 mg per day, as divided doses. Sore throat, enlarged, tender lymph nodes and fever in the absence of viral symptoms (cough and nasal congestion) …. 4.7/5 (3) Keflex Uses, Dosage & Side Effects - Drugs.com https://www.drugs.com/keflex.html Jan 10, 2019 · Do not use Keflex to treat any condition that has not been checked by your doctor. Skipping doses can increase your risk of infection that is resistant to medication. The dose of order Keflex no prescription depends on the patients age, body mass and some other ...
5 Essential Facts About Phlebitis: What is Phlebitis, what does phlebitis look like, what causes phlebitis, is phlebitis dangerous, how can it be treated. 5 minute read.
1IYQ: Acyl-intermediate Structures of the Extended-spectrum Class A beta -Lactamase, Toho-1, in Complex with Cefotaxime, Cephalothin, and Benzylpenicillin.
Dr. Menchell responded: Cephalosporin rx. Older studies suggested that there was a 5-7% risk of having a reaction to a cephalosporin if you had a history of |a href=/topics/penicillin-allergy track_data={
Phlebitis is the swelling of a vein, usually because of a blood clot. There are two main types of phlebitis: superficial phelbitis...
What is Phlebitis - symptoms, treatment, pictures, definition, photos, images, causes. Phlebitis is a condition characterized by inflammation of a vein
Rolitetracycline, a derivative of tetracycline, is a broad-spectrum antibiotic. Rolitetracyclin has a role as a protein synthesis inhibitor, an antiprotozoal drug and a prodrug. - Mechanism of Action & Protocol.
Cefuroxime Axetil is the name of the medication. It comes in the form of a tablet, and should be taken by mouth. It belongs to a class of medications called Cephalosporin Antibiotic.
Chinese scientists who have fully sequenced the genome of the new E. Coli spreading through Europe said Saturday they found genes in the bacteria that gave it resistance to eight classes of antibiotics. Researchers with the Beijing Genomics Institute, the worlds largest DNA sequencing center, have found genes in the newly identified 0104 strain of E. Coli bacteria that made it resistant to major classes of antibiotics including sulfonamide, cephalothin, penicillin and streptomycin.. This helped explain why doctors in Europe had difficulties in fighting the bug that has killed 18 people and sickened nearly 2,000, BGIs major research arm in Shenzhen said on its website Saturday.. This would help doctors choose right medicines for the treatment, it said.. The researchers are developing a diagnostic kit which will be used to detect the bacteria and prevent the epidemic from spreading further.. The Chinese researchers obtained DNA samples of the bacteria from collaborating scientists in Germany and ...
Phlebitis means inflammation of a vein. It most commonly happens on the superficial veins of the legs, particularly if these happen to be damaged or varicose veins. How can phlebitis be prevented?
Parabolic Drugs Limited (PDL), a leading research based API manufacturer with stronghold in Antibiotic space and marking its presence in the Custom Synthesis and Contract manufacturing (CRAMS) segment has posted a 36.29% rise in net profit at Rs. 10.53 crore for the first quarter ended June 2010, as compared to Rs. 7.73 cr in the corresponding period of the previous year. The companys Q1 gross Sales stood at Rs. 140.15 cr from Rs. 112.71 cr., up by 24.35% supported by launch of new Sterile Cephalosporin antibiotic API and through penetration in newer geographies. EBIDTA rose to Rs. 25.74 crore up by 52.13% as compared to Rs. 16.92 crore in the corresponding period in previous year. This was mainly due to increased share in sales of high value Cephalosporin APIs. Parabolic is extremely bullish about its estimations for FY2011.. The total income & EBIDTA margins are estimated to be Rs.705 crs & Rs. 128 crs correspondingly. The projected PAT for FY2011 is estimated to reach approximately Rs. 54 ...
The model itself though, was less to my linking. It goes way too low at the later times. Upon consideration, since the model assumes homoscedastic error it does not matter to the likelihoood if the fit at the lower end is not so good. After all, an error of 1 is nothing compared to errors of 10 or 20 at the upper end of the scale. In addition it can be argued that the error is not homoscedastic. If it were homoscedastic, the underlying data would show way more variation at the lower end of the scale. It would need confirmation from the measuring team, but for now I will assume proportional error ...
Susceptibility of Anaerobic Bacteria to Cefoxitin and Related Compounds: Cephalothin, cefazolin, cephradine, and cefoxitin inhibited more than 75% of 326 anaero
Looking for online definition of septic phlebitis in the Medical Dictionary? septic phlebitis explanation free. What is septic phlebitis? Meaning of septic phlebitis medical term. What does septic phlebitis mean?
Semantic Scholar extracted view of Experiences with three cephalosporin antibiotics in respiratory system infections. by Eric J Benner
Buy Cheap on line Antibiotics - Alexcef (Brand name: cephalexin) - Cephalexin is a cephalosporin antibiotic used in the treatment of respiratory infections and ear infections.
Davidian and Giltinan (1995, 1.1, p. 2) describe data obtained during a pilot study to investigate the pharmacokinetics of the drug cefamandole. Plasma concentrations of the drug were measured on six healthy volunteers at 14 time points following an intraveneous dose of 15 mg/kg body weight of cefamandole. ...
Cephalexin is the name of the medication. It comes in the form of a capsule, and should be taken by mouth. It belongs to a class of medications called Cephalosporin Antibiotic.
Itchy blood - Whats the cause of itchy blood clots on the thighs? Phlebitis. Superficial phlebitis is usually caused by local trauma to a vein. Superficial phlebitis may or not have a blood clot form to cause the pain and inflammation. In the legs, superficial phlebitis can be associated with varicose veins. Inactivity (blood pools in the veins and tends to clot if a person is inactive for a prolonged period of time); trauma, and blood clotting abnormalities.
phlebitis was found in Nursing Central. Nursing Central is an award-winning, complete mobile solution for nurses and students. Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms.
Buy Cefoprox Online! Cefoprox is used to treat bacterial infections in many different parts of the body. It belongs to the class of medicines known as cephalosporin antibiotics.
Buy and view Cefradine, zwitterion cephalosporin antibiotic, 38821-53-3, MSDS. Click to view prices and info for Cefradine on TOKU-E.com
Generic Omnicef 300mg is a cephalosporin antibiotic used to treat of mild to moderate infections. Purchase from InternationalDrugMart and save money.
Professional guide for CeFAZolin. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
ASTRAL is associated with leading national and multinational pharma companies like Pfizer, Ranbaxy, Zydus Cadila, Cipla, Orchid, Alembic, Sun Pharma, Blue Cross, Intas, Unique and Dr. Reddys, as the contract manufacturer for their products for domestic and export segments. The sterile dry powder Injectable division manufactures products comprising of Beta-Lactam and Cephalosphorin group of formulations, at the independent and dedicated facilities for each group. The major products of Cephalosphorin group are : Ceftazidime for injection, Cefuroxime for injection, Cefotaxime for injection, Cefoperazone for injection, Ceftriaxone for injection, Cefpirom for Injection, Cefoperazon Sodium and Salbactum Sodium for Injection. The products like Cephalothin for Injection, Cefepime Hydrochloride for Injection, Cefpiramide for Injection etc are streamlined for future introduction. The major products of Penicillin group are : Amoxicillin for Injection, Ampicillin for Injection, Cloxacillin for Injection, , ...
1CEF: Binding of cephalothin and cefotaxime to D-ala-D-ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum beta-lactamases.
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casSAR Dugability of O69395 | bla | Beta-lactamase Toho-2 - Also known as BLT2_ECOLX, bla. Hydrolyzes beta-lactam antibiotics such as penicillin G, carbenicillin, cephaloridine, cefoxitin, cefotaxime, ceftazidime, and aztreonam. Has especially increased relative hydrolysis rates for cephalothin, cephaloridine, cefotaxime and ceftizoxime.
What this means is that changes in the frequency of resistant organisms, for better or for worse, depend not only on antibiotic use, but also on other ecological dynamics-that is, because of clonal spread. In other words, a resistant strain might not become more common because it is resistant, but because it does something else better than most other strains (e.g., it might be hard for the immune system to recognize and attack it).. A recent paper about antibiotic resistance in E. coli that cause urinary tract infections (UTI) indicates that clonal spread is driving antibiotic resistance. The researchers collected a total of 780 isolates of E. coli from every referred patient at a university health center with UTI during a 14-week period for four consecutive years. What they found was that there was no trend (up or down) in the frequency of resistance to trimethoprim-sulfamethoxazole, ciprofloxacin, cephalothin, or nitrofurantoin. Only ampicillin (amoxicillin) decreased significantly from year ...
Known fecal streptococci isolates were obtained from livestock, humans, wildlife and domestic pets and subjected to carbon source oxidation analysis and antibiotic resistance analysis. Antibiotics used were: chlortetracycline, oxytetracycline, streptomycin, cephalothin, erythromycin, tetracycline, neomycin, vancomycin, and amoxicillin. Antibiotics were used on average at three different concentrations. This database constitutes a set of known patterns and currently consists of over 1,200 individual isolates. Unknown water samples were obtained from the following sites: Cheyenne Bottoms Refuge, Quivira National Wildlife Refuge, sites near St. Johns Kansas, streams on the Konza prairie, Tuttle Creek Reservoir, Black Vermillion River, Cheney Lake, the Arkansas River that runs through Wichita. Additional sites within Kansas, too numerous to mention, were also sampled. Fecal streptoccocci from these samples were also selected and analyzed using carbon source oxidation assays and antibiotic ...
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Cefuroxime is an enteral second-generation cephalosporin antibiotic. It was discovered by the Glaxo, now GlaxoSmithKline and first marketed in 1978 as Zinacef. It received approval from the U.S. Food and Drug Administration in October 1983.. Cefuroxime is used to treat a wide variety of bacterial infections. This medication is known as a cephalosporin antibiotic. It works by stopping the growth of bacteria.. This antibiotic treats only bacterial infections. It will not work for viral infections (e.g., common cold, flu). Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.. ...
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Definition of Dicloxacillin sodium with photos and pictures, translations, sample usage, and additional links for more information.
As described in this eMedTV page, some people who take dicloxacillin may develop complications like watery or bloody diarrhea. This page covers other precautions for using dicloxacillin safely, including warnings for those who should not take the drug.
in Biochimica et Biophysica Acta (1998), 1379(1), 61-8. We demonstrated that the cephalosporin antibiotic ceftazidime (CAZ) deactivated singlet oxygen (1O2). We then studied the mechanisms of the CAZ effects on the ultra weak chemiluminescence (uwCL ... [more ▼]. We demonstrated that the cephalosporin antibiotic ceftazidime (CAZ) deactivated singlet oxygen (1O2). We then studied the mechanisms of the CAZ effects on the ultra weak chemiluminescence (uwCL) associated with the energy decay of 1O2 generated by the Mallet reaction (H2O2 + HOCl --, HCl + H2O + 1O2), and on the anthracene-9,10-dipropionic acid (AAP) consumption by 1O2 generated by irradiation of Rose Bengal (RB). The uwCL generated by the Mallet reaction was amplified (6.2 times) by CAZ. The use of red and blue filters, which absorb radiation below 610 nm and between 470 and 700 nm respectively, demonstrated that CAZ increased the uwCL by a radiation emission at wavelengths shorter than the 633 and 704 nm wavelength emissions of 1O2. ...
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A cephalosporin antibiotic sometimes used as prophylaxis during anticipated neutropenic nadirs. No known antineoplastic properties. ...
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cefazolin delta-2-methyl ester: RN given refers to (6R-trans)-isomer; RN for cpd without isomeric designation not available 2/91; structure given in first source
Infrared imaging (IR) is a noninvasive technique that quantifies body surface temperature by capturing the thermal radiation emitted and producing a high-resolution digital image called a thermogram1. The information is made visible via a color scale where the warmest areas are depicted as white or red, while the coolest areas appear blue or black2. IR has been used to study diseases in which skin temperature can reflect the presence of inflammation in underlying tissues, or those in which blood flow is increased or decreased because of a clinical abnormality1,2. It is widely known that animal venoms are capable of inducing localized reactions involving inflammation and pain3. One of the challenges that clinicians face when treating patients envenomed by venomous animals is a lack of suitable clinical tools for accurate assessment of the localized effects caused by different venoms in order to provide refined criteria for choosing the best therapeutic option, especially the most efficacious use ...
"In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin- ...
... cephalothin plus kanamycin. And only one research found that tetracycline is more effective to decrease the time of fever than ...
... cephalothin), was launched by Eli Lilly and Company in 1964.[citation needed] "cephalosporin". Merriam-Webster Dictionary. " ...
সেফালোথিন (Cephalothin). *সেফাজোলিন (Cefazolin). দ্বিতীয় প্রজন্ম[সম্পাদনা]. *সেফাক্লর (Cefaclor). *সেফুরোক্সিম (Cefuroxime). * ...
... sodium - [USP] the monosodium salt of cephalothin, used in the treatment of infections of the major organ and ... cephalothin - Cephalosporin Ceph a*lo*spor in (s[e^]f [.a]*l[ o]*sp[=o]r [i^]n), n. [from Cephalosporium, a fungus producing ... cephalothin. ceph·a·lo·thin (sĕfʹə-lə-thĭn) n. A semisynthetic analogue of cephalosporin having a broad spectrum of antibiotic ... cephalothin - Chemically modified cephalosporin C, a broad spectrum antibiotic. * * * ceph·a·lo·thin sef ə lə (.)thin n a ...
Antonyms for cephalothin. 2 words related to cephalothin: cephalosporin, Mefoxin. What are synonyms for cephalothin? ... cephalothin. Also found in: Dictionary, Medical, Encyclopedia, Wikipedia.. Related to cephalothin: cephalexin, cefazolin, ... Pharmacokinetics of cephalothin and cephalexin in selected avian species.. Successful treatment of a radioulnar synostosis in a ... Words related to cephalothin. a semisynthetic analogue of cephalosporin. Related Words. *cephalosporin ...
Cephalothin (Keflin) is a first-generation cephalosporin antiobiotic used to treat certain bacterial infections in poultry. It ... Cephalothin (Keflin). Overview Cephalothin (Keflin) is a first-generation cephalosporin antiobiotic used to treat certain ...
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cephalothin. 97.2%. n=107. 99%. n=102. 85.3%. n=109. 81.8%. n=11. ... The following drugs had some data removed: gatifloxacin, penicillin, piperacillin, amoxicillin, cephalothin, cefoxitin, ...
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Cephalothin-Induced Granulocytopenia MARIO-ANTOINE DICATO, M.D.; LEONARD ELLMAN, M.D. ... Since its introduction in 1962, cephalothin (Keflin®) has assumed a major role in the therapy of bacterial infection. There ... DICATO M, ELLMAN L. Cephalothin-Induced Granulocytopenia. Ann Intern Med. 1975;83:671-672. doi: 10.7326/0003-4819-83-5-671 ... have been only sporadic reports of granulocytopenia caused by cephalothin therapy (1-3). The appearance of four such cases in a ...
Cefoxitin, a New Semi-synthetic Cephamycin: An In-vitro and In-vivo Comparison with Cephalothin Br Med J 1973; 4 :653 ... Urinary recovery of cefoxitin activity was also much higher than that of cephalothin. No evidence of toxicity due to cefoxitin ... The activity of cefoxitin was compared with that of cephalothin against 229 bacterial strains. Cefoxitin was more active ... Cefoxitin, a New Semi-synthetic Cephamycin: An In-vitro and In-vivo Comparison with Cephalothin ...
What is cephalothin sodium? Meaning of cephalothin sodium medical term. What does cephalothin sodium mean? ... Looking for online definition of cephalothin sodium in the Medical Dictionary? cephalothin sodium explanation free. ... cephalothin sodium. cephalothin sodium. [sef′əlō′thin] a parenteral first-generation cephalosporin antibiotic. indications It ... cephalothin sodium. (sĕf′ă-lō-thĭn″) A first-generation cephalosporin antibiotic that treats infections caused by gram-positive ...
Cephaloridine and Cephalothin: Pharmacodynamics in Uremia. R. L. Perkins, M.D., F.A.C.P.; E. Smith, M.D.; S. Saslaw, M.D., F.A. ... Cephalothin and Cephaloridine Therapy for Bacterial Meningitis: An Evaluation Annals of Internal Medicine; 82 (5): 689-693 ... Cephaloridine and Cephalothin: Pharmacodynamics in Uremia.. Ann Intern Med. 1968;68:1175. doi: 10.7326/0003-4819-68-5-1175_3 ... Thus, the comparative pharmacodynamics of cephalothin and cephaloridine were evaluated in a crossover study in five chronically ...
... and product complexes of cephalothin with AmpC beta-lactamase. ... WT beta-Lactamase in Complex with Covalently Bound Cephalothin ...
... cephalothin sodium and cefbuperazone sodium) during simulated Y-site injection were studied.

The mixtures were prepared by ... On the other hand, since ranitidine with cephalothin (20 mg/mL) fell below 90%, the amount of cephalothin should not exceed 10 ... except for cephalothin (86.6% of control). In the presence of 10 mg/mL cephalothin, however, ranitidine retained greater than ... Stability of Ranitidine Hydrochloride with Cefazolin Sodium, Cefbuperazone Sodium, Cefoxitin Sodium and Cephalothin Sodium ...

The generic ingredient in CEPHALOTHIN SODIUM is cephalothin sodium. There are seven drug master file entries for this compound ... NDA 062464 describes CEPHALOTHIN SODIUM, which is a drug marketed by Abbott, Abraxis Pharm, Bristol, and Baxter Hlthcare, and ... Additional details are available on the CEPHALOTHIN SODIUM profile page. ...
Cephalothin Sodium Injection 1 g and 2 g in 5% dextrose premixed bags in 50 ml D5W (frozen); Cephalothin Sodium® (Baxter); (Rx) ... Cephalothin Sodium Powder for Injection 1 g, 2 g in 10 ml vials and 100 ml piggyback vials and Faspak; Keflin®, Neutral (Lilly ... The following drugs or solutions are reportedly compatible with cephalothin: D25W/Amino Acids 4.25%, D5W in Lactated Ringers, ... Uses/Indications - In the United States, there are no cephalothin products approved for veterinary species, but it has been ...
Anaphylactic Reaction to Cephalothin during Anesthesia You will receive an email whenever this article is corrected, updated, ... Anaphylactic Reaction to Cephalothin during Anesthesia. Anesthesiology 10 1975, Vol.43, 476-478. doi: ... Jose L. Velazquez, Martin I. Gold; Anaphylactic Reaction to Cephalothin during Anesthesia. Anesthesiology 1975;43(4):476-478. ...
Cephalothin answers are found in the Johns Hopkins ABX Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, ... Cephalothin is a topic covered in the Johns Hopkins ABX Guide. To view the entire topic, please sign in or purchase a ... "Cephalothin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/ ... view/Johns_Hopkins_ABX_Guide/540108/all/Cephalothin. Avdic E, Pham PA. Cephalothin. Johns Hopkins ABX Guide. The Johns Hopkins ...
Variable degrees of acute renal failure developed in three patients receiving therapy with cephalothin sodium. The course and ... Nephrotoxicity Associated With Cephalothin Administration. Philip C. Carling, MD; Beldon A. Idelson, MD; A. Andrew Casano, MD; ... Nephrotoxicity Associated With Cephalothin Administration. Arch Intern Med. 1975;135(6):797-801. doi:10.1001/archinte. ... Variable degrees of acute renal failure developed in three patients receiving therapy with cephalothin sodium. The course and ...
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The inactivation of cephalothin differed from that of the other antibiotics. Type: Journal article Language: English Published ... flucloxacillin and cephalothin. The highest level of resistance was found to methicillin and the lowest to cephalothin. The ... In-vitro activity and beta-lactamase stability of methicillin, isoxazolyl penicillins and cephalothin against coagulase- ...
CEPHALOTHIN GROUP. C16 H18 N2 O6 S2 UUWFGEKEQSCSMB-IAQYHMDHSA-N ... Toho-1 beta-Lactamase In Complex With Cephalothin. *DOI: ...
CEPHALOTHIN, the sodium salt of 7-(thiophene2-acetamido) cephalosporanic acid, is a semisynthetic derivative of cephalosporin C ... Anaphylactoid Reaction to an Initial Dose of Sodium Cephalothin. Sherwin A. Kabins, MD; Bernard Eisenstein, MD; Sidney Cohen, ... CEPHALOTHIN, the sodium salt of 7-(thiophene2-acetamido) cephalosporanic acid, is a semisynthetic derivative of cephalosporin C ... Kabins SA, Eisenstein B, Cohen S. Anaphylactoid Reaction to an Initial Dose of Sodium Cephalothin. JAMA. 1965;193(2):165-166. ...
Cephalothin. 2009-2012. 0.016-256†. No CLSI or NARMS breakpoints. Folate pathway antagonists. Sulfisoxazole. 2015-present. 16- ...
Cephalothin. 16. 8. 2.0. bfd. 1.16 ± 0.03†. Penicillin G. 48. 32. 1.5. ...
Related to Cefalotin: cephalothin, Keflin. cephalothin. [′sef·ə·lə·thən] (microbiology) An antibiotic derived from the fungus ... cephalothin. (redirected from Cefalotin). Also found in: Dictionary, Thesaurus, Medical, Wikipedia. ...
Chemoprophylaxis in cardiac and orthopedic surgery: Comparison of cephalothin and cephapirin. Southern medical journal. 1982 ... Cephalothin and cephapirin have equivalent chemoprophylactic activity by clinical and microbiological criteria, permitting cost ... Cephalothin and cephapirin have equivalent chemoprophylactic activity by clinical and microbiological criteria, permitting cost ... Cephalothin and cephapirin have equivalent chemoprophylactic activity by clinical and microbiological criteria, permitting cost ...
Resistance to cephalothin. R. R. R. R. S(e). S. S. a Symbols: +, 90% or more of strains are positive; -, 90% or more of strains ... e Cephalothin-resistant C. fetus subsp. fetus strains have been reported.. NOTE: C. hyointestinalis requires H2 for vigorous ... Swab an Abeyta-Hunt-Bark agar plate without antibiotics with the suspension and drop nalidixic acid and cephalothin disks onto ...
Cephalothin. 12 (6.7). 0. 0. 0. Cefotaxime. 8 (4.5). 0. 0. 0. ...
Hemolysis is the premature destruction of erythrocytes. A hemolytic anemia will develop if bone marrow activity cannot compensate for the erythrocyte loss.
  • cephalothin - Chemically modified cephalosporin C, a broad spectrum antibiotic. (academic.ru)
  • Tzianabos reported similar results with different antibiotic classes including cephalothin , gentamicin and ampicillin/clavulanic acid. (freethesaurus.com)
  • One RCT comparing cefoxitin with cephalothin in 19 patients treated for chronic destructive pneumonia (8) had a thoracic surgeon as first author. (freethesaurus.com)
  • Among the penicillin-like drugs, amoxicillin and cephalothin were the most effective in stopping bacterial growth. (freethesaurus.com)
  • OY15 did show apparent resistance to ampicillin (10 [micro]g) and cephalothin (30 big) on Mueller Hinton agar during sensitivity testing. (freethesaurus.com)
  • Tzianabos reported similar results with different antibiotic classes including cephalothin , gentamicin and ampicillin/clavulanic acid. (freethesaurus.com)
  • One hundred percent of ETEC and Shigella isolates showed resistance to ampicillin, carbenicillin and cephalothin. (scirp.org)
  • The prevalence of resistance among E coli and all isolates combined was more than 20% for ampicillin, cephalothin, and sulfamethoxazole in each year studied. (nih.gov)
  • While the prevalence of resistance to trimethoprim-sulfamethoxazole, ampicillin, and cephalothin increased significantly among uropathogens causing acute cystitis, resistance to nitrofurantoin and ciprofloxacin remained infrequent. (nih.gov)
  • 75%]‎ to ampicillin, cephalothin, chloramphenicol and tetracycline. (who.int)
  • SEC plates showed good agreement with Mueller-Hinton II agar in MIC studies and can be used to screen and discriminate resistant E. coli for ampicillin, cephalothin, streptomycin, chloramphenicol, cefotaxime and gentamicin using CLSI standardized breakpoints, but not for sulphamethoxazole. (springer.com)
  • Since its introduction in 1962, cephalothin (Keflin®) has assumed a major role in the therapy of bacterial infection. (annals.org)
  • Cephalothin sodium (Keflin) occurs as a white to off-white,crystalline powder that is practically odorless. (chemicalbook.com)
  • Cephalothin (Keflin) is a first-generation cephalosporin antiobiotic used to treat certain bacterial infections in poultry. (poultrydvm.com)
  • In a retrospective sequential study we determined the rate of infection occurring despite cephalothin or cephapirin chemoprophylaxis in orthopedic and cardiac surgery done from 1973 to 1977. (elsevier.com)
  • The incidence of infection after prosthetic hip placement or open reduction of hip fracture was 3.4% and 1.0% in patients receiving cephalothin or cephapirin, respectively. (elsevier.com)
  • The infection rate after prosthetic heart valve implantation was 3.5% in those receiving cephalothin and 1.6% in those receiving cephapirin. (elsevier.com)
  • Although cephapirin was effective at lower concentration, the activity of cephalothin and cephapirin was comparable. (elsevier.com)
  • Cephalothin and cephapirin have equivalent chemoprophylactic activity by clinical and microbiological criteria, permitting cost to be used as a basis for choosing between these antibiotics. (elsevier.com)
  • The activity of cefoxitin was compared with that of cephalothin against 229 bacterial strains. (bmj.com)
  • Against Gram-positive organisms, however, cefoxitin was considerably less active than cephalothin, but minimum inhibitory concentrations for Staphylococcus aureus were well within therapeutically attainable blood levels. (bmj.com)
  • Urinary recovery of cefoxitin activity was also much higher than that of cephalothin. (bmj.com)
  • Cefoxitin was slightly less painful after intramuscular injection than cephalothin. (bmj.com)
  • One RCT comparing cefoxitin with cephalothin in 19 patients treated for chronic destructive pneumonia (8) had a thoracic surgeon as first author. (freethesaurus.com)
  • A randomized, double-blind, multicenter trial was initiated to compare the safety and efficacy of piperacillin, cephalothin and cefoxitin in the prophylactic treatment of patients undergoing vaginal hysterectomy. (elsevier.com)
  • A satisfactory prophylactic response was obtained in 143 of 151 (95 per cent) patients treated with piperacillin, in 82 of 87 (94 per cent) patients treated with cephalothin and in 57 of 60 (95 per cent) patients treated with cefoxitin. (elsevier.com)
  • Cephaloridine and Cephalothin: Pharmacodynamics in Uremia. (annals.org)
  • Unlikeampicillin, cephalothin is resistant to penicillinase producedby S. aureus and provides an alternative to the use ofpenicillinase-resistant penicillins for the treatment of infectionscaused by such strains. (chemicalbook.com)
  • It is able to grow at 25 °C, is sensitive to cephalothin, and resistant to nalidixic acid. (wikipedia.org)
  • E. N. Ramzi ,S. Obeid ,Omar A. Shafey , Methicillin resistant staphaureus at main Alexandria University Hospital: incidence, biochemical study and cross resistance to cephalothin, Bull. (who.int)
  • After reconstituting with sterile water for injection, cephalothin sodium neutral is stable for 12 hours at room temperature and 96 hours when refrigerated. (elephantcare.org)
  • Literature issued December 20, 1970 on Cephalothin Discs by Eli Lilly and Co., Indianapolis, IN. (atcc.org)
  • For the combinations vancomycin plus cephalothin and vancomycin plus imipenem the effect was additive in 76.9% and 80.7% respectively. (biomedcentral.com)
  • Vancomycin in combination with a beta-lactam (cephalothin or imipenem) showed additivity. (biomedcentral.com)
  • Cephalothin is absorbed poorly from the GI tract andmust be administered parenterally for systemic infections. (chemicalbook.com)
  • There have been only sporadic reports of granulocytopenia caused by cephalothin therapy (1-3). (annals.org)
  • Variable degrees of acute renal failure developed in three patients receiving therapy with cephalothin sodium. (jamanetwork.com)
  • No other causes for renal failure could be detected, and all recovered after discontinuation of cephalothin therapy, although peritoneal dialysis was required in one patient. (jamanetwork.com)
  • 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540108/all/Cephalothin. (hopkinsguides.com)
  • Thus, the comparative pharmacodynamics of cephalothin and cephaloridine were evaluated in a crossover study in five chronically uremic patients before and during peritoneal dialysis. (annals.org)
  • Pharmacokinetics (specific) - Cephalothin is not appreciably absorbed after oral administration and must be given parenterally to achieve therapeutic serum levels. (elephantcare.org)
  • Uses/Indications - In the United States, there are no cephalothin products approved for veterinary species, but it has been used clinically in several species when a relatively short-acting, injectable, first generation cephalosporin is indicated. (elephantcare.org)
  • Pharmacology/Spectrum of Activity - A first generation cephalosporin, cephalothin exhibits activity against the bacteria usually covered by this class. (elephantcare.org)