Cephalexin: A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.Cephradine: A semi-synthetic cephalosporin antibiotic.Cefadroxil: Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative.Cephalosporins: A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.Cephaloridine: A cephalosporin antibiotic.Cefaclor: Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.Cephalothin: A cephalosporin antibiotic.Cephaloglycin: A cephalorsporin antibiotic.Cefixime: A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.Penicillin V: A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.Skin Diseases, Infectious: Skin diseases caused by bacteria, fungi, parasites, or viruses.Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.Rats, Hairless: Mutant strains of rats that produce little or no hair. Several different homozygous recessive mutations can cause hairlessness in rats including rnu/rnu (Rowett nude), fz/fz (fuzzy), shn/shn (shorn), and nznu/nznu (New Zealand nude). Note that while NUDE RATS are often hairless, they are most characteristically athymic.Ferula: A plant genus of the family APIACEAE. It contains pungent oils and resins. It is used to flavor curries, as a carminative, and as cat and dog repellent. The occasionally used common name of 'giant fennel' should not be confused with true fennel (FOENICULUM).Dicloxacillin: One of the PENICILLINS which is resistant to PENICILLINASE.Cefazolin: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.Amdinocillin: An amidinopenicillanic acid derivative with broad spectrum antibacterial action.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Symporters: Membrane transporters that co-transport two or more dissimilar molecules in the same direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Norethindrone: A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.Infectious Mononucleosis: A common, acute infection usually caused by the Epstein-Barr virus (HERPESVIRUS 4, HUMAN). There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis.Pharyngitis: Inflammation of the throat (PHARYNX).Herpesvirus 4, Human: The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.Antibodies, Heterophile: Antibodies elicited in a different species from which the antigen originated. These antibodies are directed against a wide variety of interspecies-specific antigens, the best known of which are Forssman, Hanganutziu-Deicher (H-D), and Paul-Bunnell (P-B). Incidence of antibodies to these antigens--i.e., the phenomenon of heterophile antibody response--is useful in the serodiagnosis, pathogenesis, and prognosis of infection and latent infectious states as well as in cancer classification.Propionibacterium acnes: A bacteria isolated from normal skin, intestinal contents, wounds, blood, pus, and soft tissue abscesses. It is a common contaminant of clinical specimens, presumably from the skin of patients or attendants.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Fermentation: Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.Metabolic Engineering: Methods and techniques used to genetically modify cells' biosynthetic product output and develop conditions for growing the cells as BIOREACTORS.Technology: The application of scientific knowledge to practical purposes in any field. It includes methods, techniques, and instrumentation.Industrial Microbiology: The study, utilization, and manipulation of those microorganisms capable of economically producing desirable substances or changes in substances, and the control of undesirable microorganisms.Self-Help Devices: Devices, not affixed to the body, designed to help persons having musculoskeletal or neuromuscular disabilities to perform activities involving movement.Names: Personal names, given or surname, as cultural characteristics, as ethnological or religious patterns, as indications of the geographic distribution of families and inbreeding, etc. Analysis of isonymy, the quality of having the same or similar names, is useful in the study of population genetics. NAMES is used also for the history of names or name changes of corporate bodies, such as medical societies, universities, hospitals, government agencies, etc.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Needles: Sharp instruments used for puncturing or suturing.Foot: The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.Chickens: Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.Bees: Insect members of the superfamily Apoidea, found almost everywhere, particularly on flowers. About 3500 species occur in North America. They differ from most WASPS in that their young are fed honey and pollen rather than animal food.Vaccinium myrtillus: A plant species of the family VACCINIUM.Pollination: The transfer of POLLEN grains (male gametes) to the plant ovule (female gamete).Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Materia Medica: Materials or substances used in the composition of traditional medical remedies. The use of this term in MeSH was formerly restricted to historical articles or those concerned with traditional medicine, but it can also refer to homeopathic remedies. Nosodes are specific types of homeopathic remedies prepared from causal agents or disease products.Health Food: A non-medical term defined by the lay public as a food that has little or no preservatives, which has not undergone major processing, enrichment or refinement and which may be grown without pesticides. (from Segen, The Dictionary of Modern Medicine, 1992)Consumer Product SafetyAustralia: The smallest continent and an independent country, comprising six states and two territories. Its capital is Canberra.Insurance, Pharmaceutical Services: Insurance providing for payment of services rendered by the pharmacist. Services include the preparation and distribution of medical products.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Information Services: Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.

Neural modulation of cephalexin intestinal absorption through the di- and tripeptide brush border transporter of rat jejunum in vivo. (1/244)

Intestinal absorption of beta-lactamine antibiotics (e.g., cefixime and cephalexin) has been shown to proceed through the dipeptide carrier system. In a previous study, nifedipine (NFP), an L-type calcium channel blocker, enhanced the absorption of cefixime in vivo but not in vitro, and it was suggested that neural mechanisms might be involved in the effect of NFP. The aim of the present study was to assess the involvement of the nervous system on the intestinal absorption of cephalexin (CFX). To investigate this, we used a single-pass jejunal perfusion technique in rats. NFP and diltiazem enhanced approximately 2-fold the plasma levels of CFX in treated rats versus untreated controls. NFP also increased approximately 2-fold the CFX level in portal plasma and increased urinary excretion of CFX, thus indicating that CFX did effectively increase CFX intestinal absorption. Perfusing high concentrations of dipeptides in the jejunal lumen competitively reduced CFX absorption and inhibited the enhancement of CFX absorption produced by NFP. Hexamethonium and lidocaine inhibited the effect of NFP, whereas atropine, capsaicin, clonidine, and isoproterenol enhanced CFX absorption by the same order of magnitude as NFP. Thus, complex neural networks can modulate the function of the intestinal di- and tripeptide transporter. Sympathetic noradrenergic fibers, intestinal sensory neurons, and nicotinic synapses are involved in the increase of CFX absorption produced by NFP.  (+info)

Mechanism of DNA segregation in prokaryotes: ParM partitioning protein of plasmid R1 co-localizes with its replicon during the cell cycle. (2/244)

The parA locus of plasmid R1 encodes a prokaryotic centromere-like system that mediates genetic stabilization of plasmids by an unknown mechanism. The locus codes for two proteins, ParM and ParR, and a centromere-like DNA region (parC) to which the ParR protein binds. We showed recently that ParR mediates specific pairing of parC-containing DNA molecules in vitro. To obtain further insight into the mechanism of plasmid stabilization, we examined the intracellular localization of the components of the parA system. We found that ParM forms discrete foci that localize to specific cellular regions in a simple, yet dynamic pattern. In newborn cells, ParM foci were present close to both cell poles. Concomitant with cell growth, new foci formed at mid-cell. A point mutation that abolished the ATPase activity of ParM simultaneously prevented cellular localization and plasmid partitioning. A parA-containing plasmid localized to similar sites, i.e. close to the poles and at mid-cell, thus indicating that the plasmid co-localizes with ParM. Double labelling of single cells showed that plasmid DNA and ParM indeed co-localize. Thus, our data indicate that parA is a true partitioning system that mediates pairing of plasmids at mid-cell and subsequently moves them to the cell poles before cell division.  (+info)

Enzymatic synthesis of beta-lactam antibiotics using penicillin-G acylase in frozen media. (3/244)

Penicillin-G acylase (EC 3.5.1.11) from Escherichia coli catalyzed the synthesis of various beta-lactam antibiotics in ice at -20 degrees C with higher yields than obtained in solution at 20 degrees C. The initial ratio between aminolysis and hydrolysis of the acyl-enzyme complex in the synthesis of cephalexin increased from 1.3 at 20 degrees C to 25 at -20 degrees C. The effect on the other antibiotics studied was less, leading us to conclude that freezing of the reaction medium influences the hydrolysis of each nucleophile-acyl-enzyme complex to a different extent. Only free penicillin-G acylase could perform transformations in frozen media: immobilized preparations showed a low, predominantly hydrolytic activity under these conditions.  (+info)

Recovery of a second instar Gasterophilus larva in a human infant: a case report. (4/244)

We report a case in an infant of horse bot fly myiasis that was unusual because the maggot had developed to the second instar (of three potential instars). This represents the first report of such late development in a human. The case occurred in a rural area of the Pacific northwest (Washington) in late summer.  (+info)

3-Deacetoxy-7-(alpha-amino-1-cyclohexenylacetamido) cephalosporanic acid (SCE-100), a new semisynthetic cephalosporin. II. Comparative in vivo antibacterial activities of SCE-100 and cephalexin (CEX). (5/244)

The protective activity of 3-deacetoxy-7-(alpha-amino-1-cyclohexenylacetamido) cephalosporanic acid (SCE-100) against experimental intraperitoneal infections in mice caused by several strains of Gram-positive and Gram-negative organisms, including penicillin resistant strains, was compared with that of cephalexin (CEX). Comparable protective effects by oral administration of SCE-100 and CEX were observed in mice infected with Gram-positive organisms, while in mice infected with Gram-negative organisms SCE-100 was less active than CEX. SCE-100 showed a protective effect in infections of mice with either penicillin G-resistant Staphylococcus aureus or ampicillin-resistant Escherichia coli. The oral ED50 of SCE-100 was similar to or slightly larger than the subcutaneous value.  (+info)

Effect of cellular filamentation on adventurous and social gliding motility of Myxococcus xanthus. (6/244)

Filamentous bacterial cells often provide biological information that is not readily evident in normal-size cells. In this study, the effect of cellular filamentation on gliding motility of Myxococcus xanthus, a Gram-negative social bacterium, was investigated. Elongation of the cell body had different effects on adventurous and social motility of M. xanthus. The rate of A-motility was insensitive to cell-body elongation whereas the rate of S-motility was reduced dramatically as the cell body got longer, indicating that these two motility systems work in different ways. The study also showed that filamentous wild-type cells glide smoothly with relatively straight, long cell bodies. However, filamentous cells of certain social motility mutants showed zigzag, tangled cell bodies on a solid surface, apparently a result of a lack of coordination between different fragments within the filaments. Further genetic and biochemical analyses indicated that the uncoordinated movements of these mutant filaments were correlated with the absence of cell surface fibril materials, indicating a possible new function for fibrils.  (+info)

Bacteremic pneumonia caused by a single clone of Streptococcus pneumoniae with different optochin susceptibilities. (7/244)

Two isolates of Streptococcus pneumoniae having different optochin susceptibilities were recovered from a blood sample of a 2-year-old boy with community-acquired pneumonia. The two isolates were documented to belong to a single clone on the basis of the isolates' identical serotype (23F), antibiograms by the E-test, random amplified polymorphic DNA patterns generated by arbitrarily primed PCR, pulsed-field gel electrophoresis, and restriction fragment length polymorphism of the penicillin-binding protein genes pbp2b and pbp2x.  (+info)

Efficacy of a new cream formulation of mupirocin: comparison with oral and topical agents in experimental skin infections. (8/244)

A new cream formulation of mupirocin developed to improve patient compliance was compared with systemic and topical antibiotics commonly used to treat primary and secondary skin infections. A mouse surgical wound model infected with Staphylococcus aureus or Streptococcus pyogenes was used. Topical treatment was applied at 4 and 10 h postinfection or oral treatment at a clinically relevant dose was administered 4, 8, and 12 h postinfection; treatments were continued three times daily for a further 3 days. Mupirocin cream was significantly more effective than (P < 0.01; two of eight studies) or not significantly different from (six of eight studies) mupirocin ointment in reducing bacterial numbers. Mupirocin cream was similar in efficacy to oral flucloxacillin but significantly more effective (P < 0.001) than oral erythromycin. It was also similar in efficacy to cephalexin against S. pyogenes but superior against S. aureus (P < 0.01). Mupirocin cream had a similar efficacy to fusidic acid cream against S. aureus but was significantly superior against S. pyogenes (P < 0.01). A hamster impetigo model infected with S. aureus was also used. Topical or oral treatment was administered at 24 and 30 h postinfection (also 36 h postinfection for oral therapy) and then three times daily for a further 2 days. On day 5, mupirocin cream was significantly more effective than mupirocin ointment in one study (P < 0.01) and of similar efficacy in the other two studies. Mupirocin cream was not significantly different from fusidic acid cream or neomycin-bacitracin cream, but it was significantly superior (P < 0.01) to oral erythromycin and cephalexin. Mupirocin cream was as effective as, or superior to, oral and other topical agents commonly used for skin infections.  (+info)

*Cefalexin

... , also spelled cephalexin, is an antibiotic that can treat a number of bacterial infections. It kills gram-positive ... Cefalexin is the INN and BAN while cephalexin is the USAN and AAN. Common brand names for cefalexin include Keflex, Cepol, ... "Cephalexin Side Effects". Drugs.com. Archived from the original on 8 February 2015. Retrieved 9 February 2015. "Cefalexin". ... Jayasagar G, Krishna Kumar M, Chandrasekhar K, Madhusudan Rao C, Madhusudan Rao Y (2002). "Effect of cephalexin on the ...

*Mastitis

Dicloxacillin or cephalexin are sometimes recommended. The effects of antibiotics has not been well studied as of 2013. An ... When infection is present, antibiotics such as cephalexin may be recommended. Breastfeeding should typically be continued, as ...

*Cellulitis

Treatment is typically with antibiotics taken by mouth, such as cephalexin, amoxicillin, or cloxacillin. In those who are ... June 2000). "Failure of treatment with cephalexin for Lyme disease". Archives of Family Medicine. 9 (6): 563-7. doi:10.1001/ ...

*List of veterinary drugs

cefpodoxime - Antibiotic cephalexin - Antibiotic, particularly useful for susceptible Staphylococcus infections. ...

*Metformin

Jayasagar G; Krishna Kumar M; Chandrasekhar K; Madhusudan Rao C; Madhusudan Rao Y (2002). "Effect of cephalexin on the ... A small double-blind, randomized study found the antibiotic cephalexin to also increase metformin concentrations by a similar ...

*Nitrofurantoin

Other drugs used for UTIs in pregnancy include cephalexin, amoxicillin, and pivmecillinam. The drug should not be given to ...

*Vasculitis

In case of an infection, antimicrobial agents including cephalexin may be prescribed. Affected organs (such as the heart or ...

*Publix

In May 2014, Cephalexin was removed from the list due to cost increases. In March 2010, Publix announced the launch of another ...

*Urinary tract infection

Cephalexin or nitrofurantoin are typically used because they are generally considered safe in pregnancy. A kidney infection ...

*Impetigo

Antibiotics by mouth, such as cephalexin, may be used if large areas are affected. Antibiotic-resistant forms have been found. ...

*Imipenem/cilastatin

... cephalexin (Keflex), and others. Imipenem/cilastatin has the ability to kill a wide variety of bacteria. Imipenem is the active ...

*Maltese dog

The antibiotic Cephalexin has been shown to completely clear up "tear staining" in some cases. Maltese are susceptible to " ...

*Doxycycline

Chodosh S, Tuck J, Pizzuto D (1988). "Comparative trials of doxycycline versus amoxicillin, cephalexin and enoxacin in ...

*Methicillin-resistant Staphylococcus aureus

Both CA-MRSA and HA-MRSA are resistant to traditional anti-staphylococcal beta-lactam antibiotics, such as cephalexin. CA-MRSA ...

*Gingivitis

Either amoxicillin, cephalexin, or minocycline in 16 ounces of a non-alcoholic fluoride mouthwash is an effective mixture. ...

*Hikma Pharmaceuticals

Generics Hikma's oral generic products are sold in the US and include such products as amoxicillin, cephalexin, doxycycline, ...

*Bullous impetigo

... such as cephalexin. Cases that do not resolve with initial antibiotic therapy or require hospitalization may also be indicative ...

*Paronychia

Antibiotics such as clindamycin or cephalexin are also often used, the first being more effective in areas where MRSA is common ...

*Discovery and development of cephalosporins

As an example three drugs from this class (Cephalexin, Cephradine and Cefadroxil) all have a single methyl group at position C- ...

*SmithKline Corp. v. Eli Lilly & Co.

It subsequently introduced four additional cephalosporin drugs: in 1972 Keflex (cephalexin), in 1967 Loridine (cephaloridine), ...

*Oritavancin

10-14 days of Vancomycin/Cephalexin in the Treatment of Patients with Complicated Skin and Skin Structure Infections (cSSSI ... relative reduction in the overall incidence of adverse events versus vancomycin/cephalexin in the second and larger pivotal ... with oritavancin achieving efficacy with fewer days of therapy than the comparator agents vancomycin followed by cephalexin. ...

*Targanta Therapeutics Corporation

... vancomycin followed by cephalexin). In addition, oritavancin showed a significantly improved safety profile with a 19.2 percent ... relative reduction in the overall incidence of adverse events versus vancomycin/cephalexin (p. ...

*Epididymitis

... cephalexin) can be used. Household remedies such as elevation of the scrotum and cold compresses applied regularly to the ...

*Jens Nielsen

... a precursor for cephalexin. He also worked on characterization of many other fermentation processes used for antibiotics ...

*Bordet-Gengou agar

... with an antibiotic such as cephalexin or penicillin and sometimes nicotinamide. The potato extract provided nitrogen and ...

*Abscess

... strep species as cause that are still sensitive to traditional anti-staphylococcus agents such as dicloxacillin or cephalexin ...
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Cephalexin - Cephalexin is a cephalosporin antibiotic used to treat urinary tract infections, respiratory tract infections, and skin and soft tissue infections.
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Cephalexin - Cephalexin is a cephalosporin antibiotic used to treat urinary tract infections, respiratory tract infections, and skin and soft tissue infections.
Cephalexin - Cephalexin is a cephalosporin antibiotic used to treat urinary tract infections, respiratory tract infections, and skin and soft tissue infections.
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