A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.
A semi-synthetic cephalosporin antibiotic.
Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
A cephalosporin antibiotic.
Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.
A cephalosporin antibiotic.
A cephalorsporin antibiotic.
A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.
A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.
Skin diseases caused by bacteria, fungi, parasites, or viruses.
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Mutant strains of rats that produce little or no hair. Several different homozygous recessive mutations can cause hairlessness in rats including rnu/rnu (Rowett nude), fz/fz (fuzzy), shn/shn (shorn), and nznu/nznu (New Zealand nude). Note that while NUDE RATS are often hairless, they are most characteristically athymic.
A plant genus of the family APIACEAE. It contains pungent oils and resins. It is used to flavor curries, as a carminative, and as cat and dog repellent. The occasionally used common name of 'giant fennel' should not be confused with true fennel (FOENICULUM).
One of the PENICILLINS which is resistant to PENICILLINASE.
A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
An amidinopenicillanic acid derivative with broad spectrum antibacterial action.
Substances that reduce the growth or reproduction of BACTERIA.
Membrane transporters that co-transport two or more dissimilar molecules in the same direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.

Neural modulation of cephalexin intestinal absorption through the di- and tripeptide brush border transporter of rat jejunum in vivo. (1/244)

Intestinal absorption of beta-lactamine antibiotics (e.g., cefixime and cephalexin) has been shown to proceed through the dipeptide carrier system. In a previous study, nifedipine (NFP), an L-type calcium channel blocker, enhanced the absorption of cefixime in vivo but not in vitro, and it was suggested that neural mechanisms might be involved in the effect of NFP. The aim of the present study was to assess the involvement of the nervous system on the intestinal absorption of cephalexin (CFX). To investigate this, we used a single-pass jejunal perfusion technique in rats. NFP and diltiazem enhanced approximately 2-fold the plasma levels of CFX in treated rats versus untreated controls. NFP also increased approximately 2-fold the CFX level in portal plasma and increased urinary excretion of CFX, thus indicating that CFX did effectively increase CFX intestinal absorption. Perfusing high concentrations of dipeptides in the jejunal lumen competitively reduced CFX absorption and inhibited the enhancement of CFX absorption produced by NFP. Hexamethonium and lidocaine inhibited the effect of NFP, whereas atropine, capsaicin, clonidine, and isoproterenol enhanced CFX absorption by the same order of magnitude as NFP. Thus, complex neural networks can modulate the function of the intestinal di- and tripeptide transporter. Sympathetic noradrenergic fibers, intestinal sensory neurons, and nicotinic synapses are involved in the increase of CFX absorption produced by NFP.  (+info)

Mechanism of DNA segregation in prokaryotes: ParM partitioning protein of plasmid R1 co-localizes with its replicon during the cell cycle. (2/244)

The parA locus of plasmid R1 encodes a prokaryotic centromere-like system that mediates genetic stabilization of plasmids by an unknown mechanism. The locus codes for two proteins, ParM and ParR, and a centromere-like DNA region (parC) to which the ParR protein binds. We showed recently that ParR mediates specific pairing of parC-containing DNA molecules in vitro. To obtain further insight into the mechanism of plasmid stabilization, we examined the intracellular localization of the components of the parA system. We found that ParM forms discrete foci that localize to specific cellular regions in a simple, yet dynamic pattern. In newborn cells, ParM foci were present close to both cell poles. Concomitant with cell growth, new foci formed at mid-cell. A point mutation that abolished the ATPase activity of ParM simultaneously prevented cellular localization and plasmid partitioning. A parA-containing plasmid localized to similar sites, i.e. close to the poles and at mid-cell, thus indicating that the plasmid co-localizes with ParM. Double labelling of single cells showed that plasmid DNA and ParM indeed co-localize. Thus, our data indicate that parA is a true partitioning system that mediates pairing of plasmids at mid-cell and subsequently moves them to the cell poles before cell division.  (+info)

Enzymatic synthesis of beta-lactam antibiotics using penicillin-G acylase in frozen media. (3/244)

Penicillin-G acylase (EC 3.5.1.11) from Escherichia coli catalyzed the synthesis of various beta-lactam antibiotics in ice at -20 degrees C with higher yields than obtained in solution at 20 degrees C. The initial ratio between aminolysis and hydrolysis of the acyl-enzyme complex in the synthesis of cephalexin increased from 1.3 at 20 degrees C to 25 at -20 degrees C. The effect on the other antibiotics studied was less, leading us to conclude that freezing of the reaction medium influences the hydrolysis of each nucleophile-acyl-enzyme complex to a different extent. Only free penicillin-G acylase could perform transformations in frozen media: immobilized preparations showed a low, predominantly hydrolytic activity under these conditions.  (+info)

Recovery of a second instar Gasterophilus larva in a human infant: a case report. (4/244)

We report a case in an infant of horse bot fly myiasis that was unusual because the maggot had developed to the second instar (of three potential instars). This represents the first report of such late development in a human. The case occurred in a rural area of the Pacific northwest (Washington) in late summer.  (+info)

3-Deacetoxy-7-(alpha-amino-1-cyclohexenylacetamido) cephalosporanic acid (SCE-100), a new semisynthetic cephalosporin. II. Comparative in vivo antibacterial activities of SCE-100 and cephalexin (CEX). (5/244)

The protective activity of 3-deacetoxy-7-(alpha-amino-1-cyclohexenylacetamido) cephalosporanic acid (SCE-100) against experimental intraperitoneal infections in mice caused by several strains of Gram-positive and Gram-negative organisms, including penicillin resistant strains, was compared with that of cephalexin (CEX). Comparable protective effects by oral administration of SCE-100 and CEX were observed in mice infected with Gram-positive organisms, while in mice infected with Gram-negative organisms SCE-100 was less active than CEX. SCE-100 showed a protective effect in infections of mice with either penicillin G-resistant Staphylococcus aureus or ampicillin-resistant Escherichia coli. The oral ED50 of SCE-100 was similar to or slightly larger than the subcutaneous value.  (+info)

Effect of cellular filamentation on adventurous and social gliding motility of Myxococcus xanthus. (6/244)

Filamentous bacterial cells often provide biological information that is not readily evident in normal-size cells. In this study, the effect of cellular filamentation on gliding motility of Myxococcus xanthus, a Gram-negative social bacterium, was investigated. Elongation of the cell body had different effects on adventurous and social motility of M. xanthus. The rate of A-motility was insensitive to cell-body elongation whereas the rate of S-motility was reduced dramatically as the cell body got longer, indicating that these two motility systems work in different ways. The study also showed that filamentous wild-type cells glide smoothly with relatively straight, long cell bodies. However, filamentous cells of certain social motility mutants showed zigzag, tangled cell bodies on a solid surface, apparently a result of a lack of coordination between different fragments within the filaments. Further genetic and biochemical analyses indicated that the uncoordinated movements of these mutant filaments were correlated with the absence of cell surface fibril materials, indicating a possible new function for fibrils.  (+info)

Bacteremic pneumonia caused by a single clone of Streptococcus pneumoniae with different optochin susceptibilities. (7/244)

Two isolates of Streptococcus pneumoniae having different optochin susceptibilities were recovered from a blood sample of a 2-year-old boy with community-acquired pneumonia. The two isolates were documented to belong to a single clone on the basis of the isolates' identical serotype (23F), antibiograms by the E-test, random amplified polymorphic DNA patterns generated by arbitrarily primed PCR, pulsed-field gel electrophoresis, and restriction fragment length polymorphism of the penicillin-binding protein genes pbp2b and pbp2x.  (+info)

Efficacy of a new cream formulation of mupirocin: comparison with oral and topical agents in experimental skin infections. (8/244)

A new cream formulation of mupirocin developed to improve patient compliance was compared with systemic and topical antibiotics commonly used to treat primary and secondary skin infections. A mouse surgical wound model infected with Staphylococcus aureus or Streptococcus pyogenes was used. Topical treatment was applied at 4 and 10 h postinfection or oral treatment at a clinically relevant dose was administered 4, 8, and 12 h postinfection; treatments were continued three times daily for a further 3 days. Mupirocin cream was significantly more effective than (P < 0.01; two of eight studies) or not significantly different from (six of eight studies) mupirocin ointment in reducing bacterial numbers. Mupirocin cream was similar in efficacy to oral flucloxacillin but significantly more effective (P < 0.001) than oral erythromycin. It was also similar in efficacy to cephalexin against S. pyogenes but superior against S. aureus (P < 0.01). Mupirocin cream had a similar efficacy to fusidic acid cream against S. aureus but was significantly superior against S. pyogenes (P < 0.01). A hamster impetigo model infected with S. aureus was also used. Topical or oral treatment was administered at 24 and 30 h postinfection (also 36 h postinfection for oral therapy) and then three times daily for a further 2 days. On day 5, mupirocin cream was significantly more effective than mupirocin ointment in one study (P < 0.01) and of similar efficacy in the other two studies. Mupirocin cream was not significantly different from fusidic acid cream or neomycin-bacitracin cream, but it was significantly superior (P < 0.01) to oral erythromycin and cephalexin. Mupirocin cream was as effective as, or superior to, oral and other topical agents commonly used for skin infections.  (+info)

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Cephalexin is a Generic name for a first-generation cephalosporin antibiotic that works by fighting bacteria in the body. It is usually prescribed to treat respiratory tract, skin, bone, middle ear and UTI - urinary tract infections. Cephalexin and other cephalosporins are broad-spectrum antibiotics are used to treat a various types of infections caused by many different bacteria. It is effective against both gram-negative and gram-positive bacteria. This drug is also used to prevent infections that are caused by streptococcal bacteria, including rheumatic fever. However, cephalexin isnt appropriate for sinus infections. Cephalexin should only be used when theres strong evidence to support its use. Misusing of cephalosporins can lead to serious infections from drug-resistant bacteria. Treating colds or flu symptoms with broad-spectrum antibiotics such as cephalexin can lead to antibiotic resistance and more severe infections that will be far harder to treat. Cephalexin is available in the ...
C16H17N3O4S•H2O M.W. 365.41. The nucleus of cephalexin is related to that of other cephalosporin antibiotics. The compound is a zwitterion; i.e., the molecule contains both a basic and an acidic group. The isoelectric point of cephalexin in water is approximately 4.5 to 5.. The crystalline form of cephalexin which is available is a monohydrate. It is a white crystalline solid having a bitter taste. Solubility in water is low at room temperature; 1 or 2 mg/mL may be dissolved readily, but higher concentrations are obtained with increasing difficulty.. The cephalosporins differ from penicillins in the structure of the bicyclic ring system. Cephalexin has a D-phenylglycyl group as substituent at the 7-amino position and an unsubstituted methyl group at the 3-position.. Each capsule contains cephalexin monohydrate equivalent to 250 mg (720 μmol) or 500 mg (1,439 μmol) of cephalexin.. Inactive Ingredients: CAPSULES: magnesium stearate, silicon dioxide, and sodium starch glycolate.. Capsule Shell ...
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DrugProjectFormSinglePage ,authorTag= {{VP}} ,!--Overview--> ,genericName= Cephalexin ,aOrAn= a ,drugClass= 1st generation [[cephalosporin]] ,indication= [[respiratory tract infections]] caused by [[s. pneumoniae]] and s. pyogenes, [[otitis media]], skin and skin structure infections, [[bone infections]], [[genitourinary tract infections]] ,hasBlackBoxWarning= Yes ,adverseReactions= [[diarrhea]] ,!--Black Box Warning--> ,blackBoxWarningTitle= Drug Resisitance ,blackBoxWarningBody= ,i>,span style=color:#FF0000;> ,/span>,/i> *To reduce the development of drug-resistant bacteria and maintain the effectiveness of cephalexin capsules and cephalexin for oral suspension and other antibacterial drugs, cephalexin capsules and cephalexin for oral suspension should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. ,!--Adult Indications and Dosage--> ,!--FDA-Labeled Indications and Dosage (Adult)--> ,fdaLIADAdult= =====Respiratory tract ...
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Cephalexin is a prescription drug used in the treatment of ear infections, upper respiratory infections, skin infections, and urinary tract infections. Local doctors can discuss symptoms associated with these diseases and give advice on cephalexin usage and side effects. Read on for local doctors who can prescribe cephalexin in Lawrence, KS.
Cephalexin is a prescription drug used in the treatment of ear infections, upper respiratory infections, skin infections, and urinary tract infections. Local doctors can discuss symptoms associated with these diseases and give advice on cephalexin usage and side effects. Read on for local doctors who can prescribe cephalexin in Ann Arbor, MI.
BUY ORDER Cephalexin (Cephalexin) cheap discount online for sale price cost 500 mg Cephalexin is in a group of drugs called cephalosporin antibiotics and is used to fight bacteria in the body.
Buy Cephalexin Online! Cephalexin tablets comprise Cephalexin as an active ingredient. Cephalexin is a first generation Cephalosporin - a semisynthetic, beta-lactam antibiotic of a broad spectrum activity against gram-positive and gram-negative microorganisms.
Cephalexin antibiotic is an effective medicine that is used for treatment of wide variety of bacterial infections as well as for preventing them. Such bacteria as staphylococci, streptococci, pneumococci, colon bacillus, Salmonella, hemophils are susceptive to the Cephalexin antibiotic effect. The class of drugs that includes Cephalexin is known as cephalosporins. Such drugs as Omnicef and Rocephin belong to this class as well. The list of bacterial illnesses treated with the help of Cephalexin can be supplemented with bone infections, middle ear infections, sinus infections, urinary tract infections, respiratory tract infections and heart valve infections. Continue reading →. ...
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Cephalexin with NDC 55700-145 is a a human prescription drug product labeled by Quality Care Products, Llc. The generic name of Cephalexin is cephalexin.
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Methicillin-resistant staphylococci were tested for susceptibility to cephradine, cephaloridine, cephalexin, and cefuroxime and 30 degree C and 37 degree C on ordinary media and on media of enhanced osmotic strength. The coagulase-negative strains were divided into Staphylococcus epidermis and Staphylococcus hominis. Generally the number of susceptible strains decreased with low incubation temperature and osmotic support. When Staphylococcus aureus was tested against cephalexin and cefuroxime, most were susceptible at 37 degree C whereas all were resistant at 30 degree C. A similar trend was found in the case of cephradine, where it was accentuated by osmotic support. While almost all strains of Staph. epidermidis were sensitive to all four drugs under all test conditions, the susceptibility of Staph. hominis was generally decreased by either lower incubation temperature or osmotic support or both.. ...
It is very interesting that how fast we are changing our practice lately. Still remember when we started to give double dose of TMP/SMZ plus cephalexin for cellulitis, and then we changed it to 1 dose of TMP/SMZ + cephalexin and then we doubted if cephalexin is necessary or not. JAMA published a randomized study showing Effect of Cephalexin Plus Trimethoprim-Sulfamethoxazole vs Cephalexin Alone on Clinical Cure of Uncomplicated Cellulitis. 496 patients received cephalexin plus trimethoprim-sulfamethoxazole vs cephalexin plus placebo in uncomplicated cellulitis. They found no difference in higher rates of clinical resolution of cellulitis, only slightly different in treating diabetic and adverse effect!. Link to article. ...
Moran GJ, Krishnadasan A, Mower WR, et al. Effect of cephalexin plus trimethoprim-sulfamethoxazole vs cephalexin alone on clinical cure of uncomplicated cellulitis: a randomized clinical trial. JAMA. 2017;317:2088-96. 28535235 ...
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coverage for MSSA. The usual adult dose is 250 mg every 6 hours. Sound right i feel this is too much. These include keflex dose for strep infections of. OR . Casey and Michael E. It was first introduced in the 1940s and has been the primary antibiotic for a wide range of ailments NOT adding Amoxicillin or Cephalexin to TMP/SMX, Doxycycline, or Clindamycin. Keflex belongs to a class of drugs called cephalosporins, which are antibiotics Apr 12, 2018 · Cephalexin oral capsule is a prescription medication that comes as the brand-name drug Keflex and as a generic drug. For skin and soft tissue infections, streptococcal pharyngitis and mild, uncomplicated urinary tract infections, the usual dosage is …. Will Cephalexin (Keflex) be effective for strep throat if I used Omnicef (Cefdinir) 2 weeks ago for the same thing? However, concentration of the drug can vary, and you should read the instructions and follow your vets. What Conditions does Keflex Treat? Adults: The adult dosage ranges from 1 to 4 ...
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Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.. Allergy: Some people who are allergic to penicillin antibiotics also experience allergic reactions to cephalosporins, including cephalexin. Before you take cephalexin, inform your doctor about any previous adverse reactions you have had to medications, especially cephalosporins and penicillins. Contact your doctor at once if you experience signs of an allergic reaction, such as skin rash, itching, difficulty breathing, or swelling of the face and throat.. Antibiotic-associated colitis: This medication, like other antibiotics, may cause a potentially dangerous condition called antibiotic-associated colitis (or pseudomembranous colitis). Symptoms include severe, watery diarrhea that may be ...
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.. Allergy: Some people who are allergic to penicillin antibiotics also experience allergic reactions to cephalosporins, including cephalexin. Before you take cephalexin, inform your doctor about any previous adverse reactions you have had to medications, especially cephalosporins and penicillins. Contact your doctor at once if you experience signs of an allergic reaction, such as skin rash, itching, difficulty breathing, or swelling of the face and throat.. Antibiotic-associated colitis: This medication, like other antibiotics, may cause a potentially dangerous condition called antibiotic-associated colitis (or pseudomembranous colitis). Symptoms include severe, watery diarrhea that may be ...
Arq. Inst. Biol., São Paulo, v.70, n.3, p.283-286, jul./set., 2003 The aim of this study was to evaluate minimum 1996). Cephalosporins are useful in selective media inhibition concentrations (MICs) of six antimicrobial for primary bacterial isolation; however, studies report agents (cephalexin, chloramphenicol, enrofloxacin, 2-25% susceptibility of these bacteria to cephalexin erythromycin, gentamicin, and oxytetracyline) on (ABRAHANS et al., 1990; MODOLO et al., 1991). It is therefore Campylobacter strains isolated from both diarrheic important that cephalosporin selective media are not exclusively used for the primary isolation of this bacterium; the concomitant use of filtration techniques is recommended (MODOLO, 2000). Chloramphenicol showed higher MIC values in diarrheic dogs (2-32 µg/mL) than diarrhea-free (2-8 µg/mL). Considering Fifty-one Campylobacter strains were isolated from the cloramphenicol cut-off point of 8 µg/mL for dogs: 29 Campylobacter jejuni subsp. jejuni , 14 ...
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