Centromere protein b. Medical search

A DNA-binding protein that interacts with a 17-base pair sequence known as the CENP-B box motif. The protein is localized constitutively to the CENTROMERE and plays an important role in its maintenance.

The clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division.

Nucleoproteins, which in contrast to HISTONES, are acid insoluble. They are involved in chromosomal functions; e.g. they bind selectively to DNA, stimulate transcription resulting in tissue-specific RNA synthesis and undergo specific changes in response to various hormones or phytomitogens.

Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.

Large multiprotein complexes that bind the centromeres of the chromosomes to the microtubules of the mitotic spindle during metaphase in the cell cycle.

A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.

The orderly segregation of CHROMOSOMES during MEIOSIS or MITOSIS.

A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.

An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. It mediates proper CHROMOSOME SEGREGATION and contractile ring function during CYTOKINESIS.

A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. They are involved in many aspects of cell division, including centrosome duplication, SPINDLE APPARATUS formation, chromosome alignment, attachment to the spindle, checkpoint activation, and CYTOKINESIS.

Highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres. They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated in tandem many times to form large blocks of sequence. Additionally, following the accumulation of mutations, these blocks of repeats have been repeated in tandem themselves. The degree of repetition is on the order of 1000 to 10 million at each locus. Loci are few, usually one or two per chromosome. They were called satellites since in density gradients, they often sediment as distinct, satellite bands separate from the bulk of genomic DNA owing to a distinct BASE COMPOSITION.

In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN A.

Extreme reduction of chromosome-specific alpha-satellite array is unusually common in human chromosome 21. (1/99)

Human centromeres contain large arrays of alpha-satellite DNA that are thought to provide centromere function. The arrays show size and sequence variation, but the extent to which extremely low levels of this DNA can occur on normal centromeres is unclear. Using a set of chromosome-specific alpha-satellite probes for each of the human chromosomes, we performed interphase fluorescence in situ hybridization (FISH) in a population-screening study. Our results demonstrate that extreme reduction of chromosome-specific alpha satellite is unusually common in chromosome 21 (screened with the alphaRI probe), with a prevalence of 3.70%, compared to < or =0.12% for each of chromosomes 13 and 17, and 0% for the other chromosomes. No analphoid centromere was identified in >17,000 morphologically normal chromosomes studied. All of the low-alphoid centromeres are fully functional as indicated by their mitotic stability and binding to centromere proteins CENP-B, CENP-C, and CENP-E. Sensitive metaphase FISH analysis of the low-alphoid chromosome 21 centromeres established the presence of residual alphaRI as well as other non-alphaRI alpha-satellite DNA suggesting that centromere function may be provided by (1) the residual alphaRI DNA, (2) other non-alphaRI alpha-satellite sequences, (3) a combination of 1 and 2, or (4) an activated neocentromere DNA. The low-alphoid centromeres, in particular those of chromosome 21, should provide unique opportunities for the study of the evolution and the minimal DNA requirement of the human centromere. (+info)

Uterine dysfunction and genetic modifiers in centromere protein B-deficient mice. (2/99)

Centromere protein B (CENP-B) binds constitutively to mammalian centromere repeat DNA and is highly conserved between humans and mouse. Cenpb null mice appear normal but have lower body and testis weights. We demonstrate here that testis-weight reduction is seen in male null mice generated on three different genetic backgrounds (denoted R1, W9.5, and C57), whereas body-weight reduction is dependent on the genetic background as well as the gender of the animals. In addition, Cenpb null females show 31%, 33%, and 44% reduced uterine weights on the R1, W9.5, and C57 backgrounds, respectively. Production of "revertant" mice lacking the targeted frameshift mutation but not the other components of the targeting construct corrected these differences, indicating that the observed phenotype is attributable to Cenpb gene disruption rather than a neighbouring gene effect induced by the targeting construct. The R1 and W9.5 Cenpb null females are reproductively competent but show age-dependent reproductive deterioration leading to a complete breakdown at or before 9 months of age. Reproductive dysfunction is much more severe in the C57 background as Cenpb null females are totally incompetent or are capable of producing no more than one litter. These results implicate a further genetic modifier effect on female reproductive performance. Histology of the uterus reveals normal myometrium and endometrium but grossly disrupted luminal and glandular epithelium. Tissue in situ hybridization demonstrates high Cenpb expression in the uterine epithelium of wild-type animals. This study details the first significant phenotype of Cenpb gene disruption and suggests an important role of Cenpb in uterine morphogenesis and function that may have direct implications for human reproductive pathology. (+info)

Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice. (3/99)

Centromere protein A (Cenpa for mouse, CENP-A for other species) is a histone H3-like protein that is thought to be involved in the nucleosomal packaging of centromeric DNA. Using gene targeting, we have disrupted the mouse Cenpa gene and demonstrated that the gene is essential. Heterozygous mice are healthy and fertile whereas null mutants fail to survive beyond 6.5 days postconception. Affected embryos show severe mitotic problems, including micronuclei and macronuclei formation, nuclear bridging and blebbing, and chromatin fragmentation and hypercondensation. Immunofluorescence analysis of interphase cells at day 5.5 reveals complete Cenpa depletion, diffuse Cenpb foci, absence of discrete Cenpc signal on centromeres, and dispersion of Cenpb and Cenpc throughout the nucleus. These results suggest that Cenpa is essential for kinetochore targeting of Cenpc and plays an early role in organizing centromeric chromatin at interphase. The evidence is consistent with the proposal of a critical epigenetic function for CENP-A in marking a chromosomal region for centromere formation. (+info)

Fission yeast homologs of human CENP-B have redundant functions affecting cell growth and chromosome segregation. (4/99)

Two functionally important DNA sequence elements in centromeres of the fission yeast Schizosaccharomyces pombe are the centromeric central core and the K-type repeat. Both of these DNA elements show internal functional redundancy that is not correlated with a conserved DNA sequence. Specific, but degenerate, sequences in these elements are bound in vitro by the S. pombe DNA-binding proteins Abp1p (also called Cbp1p) and Cbhp, which are related to the mammalian centromere DNA-binding protein CENP-B. In this study, we determined that Abp1p binds to at least one of its target sequences within S. pombe centromere II central core (cc2) DNA with an affinity (K(s) = 7 x 10(9) M(-1)) higher than those of other known centromere DNA-binding proteins for their cognate targets. In vivo, epitope-tagged Cbhp associated with centromeric K repeat chromatin, as well as with noncentromeric regions. Like abp1(+)/cbp1(+), we found that cbh(+) is not essential in fission yeast, but a strain carrying deletions of both genes (Deltaabp1 Deltacbh) is extremely compromised in growth rate and morphology and missegregates chromosomes at very high frequency. The synergism between the two null mutations suggests that these proteins perform redundant functions in S. pombe chromosome segregation. In vitro assays with cell extracts with these proteins depleted allowed the specific assignments of several binding sites for them within cc2 and the K-type repeat. Redundancy observed at the centromere DNA level appears to be reflected at the protein level, as no single member of the CENP-B-related protein family is essential for proper chromosome segregation in fission yeast. The relevance of these findings to mammalian centromeres is discussed. (+info)

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. (5/99)

BACKGROUND: Survivin is a mammalian protein that carries a motif typical of the inhibitor of apoptosis (IAP)proteins, first identified in baculoviruses. Although baculoviral IAP proteins regulate cell death, the yeast Survivin homolog Bir1 is involved in cell division. To determine the function of Survivin in mammals, we analyzed the pattern of localization of Survivin protein during the cell cycle, and deleted its gene by homologous recombination in mice. RESULTS: In human cells, Survivin appeared first on centromeres bound to a novel para-polar axis during prophase/metaphase, relocated to the spindle midzone during anaphase/telophase, and disappeared at the end of telophase. In the mouse, Survivin was required for mitosis during development. Null embryos showed disrupted microtubule formation, became polyploid, and failed to survive beyond 4.5days post coitum. This phenotype, and the cell-cycle localization of Survivin, resembled closely those of INCENP. Because the yeast homolog of INCENP, Sli15, regulates the Aurora kinase homolog Ipl1p, and the yeast Survivin homolog Bir1 binds to Ndc10p, a substrate of Ipl1p, yeast Survivin, INCENP and Aurora homologs function in concert during cell division. CONCLUSIONS: In vertebrates, Survivin and INCENP have related roles in mitosis, coordinating events such as microtubule organization, cleavage-furrow formation and cytokinesis. Like their yeast homologs Bir1 and Sli15, they may also act together with the Aurora kinase. (+info)

Centromere/kinetochore localization of human centromere protein A (CENP-A) exogenously expressed as a fusion to green fluorescent protein. (6/99)

Three human centromere proteins, CENP-A, CENP-B and CENP-C, are a set of autoantigens specifically recognized by anticentromere antibodies often produced by patients with scleroderma. Microscopic observation has indicated that CENP-A and CENP-C localize to the inner plate of metaphase kinetochore, while CENP-B localizes to the centromere heterochromatin beneath the kinetochore. The antigenic structure, called "prekinetochore", is also present in interphase nuclei, but little is known about its molecular organization and the relative position of these antigens. Here, to visualize prekinetochore in living cells, we first obtained a stable human cell line, MDA-AF8-A2, in which human CENP-A is exogenously expressed as a fusion to a green fluorescent protein of Aequorea victoria. Simultaneous staining with anti-CENP-B and anti-CENP-C antibodies showed that the recombinant CENP-A colocalized with the endogenous CENP-C and constituted small discrete dots attaching to larger amorphous mass of CENP-B heterochromatin. When the cell growth was arrested in G1/ S phase with hydroxyurea, CENP-B heterochromatin was sometimes highly extended, while the relative location between GFP-fused CENP-A and the endogenous CENP-C was not affected. These results indicated that the fluorescent CENP-A faithfully localizes to the centromere/kinetochore throughout the cell cycle. We then obtained several mammalian cell lines where the same GFP-fused human CENP-A construct was stably expressed and their centromere/kinetochore is fluorescent throughout the cell cycle. These cell lines will further be used for visualizing the prekinetochore locus in interphase nuclei as well as analyzing kinetochore dynamics in the living cells. (+info)

Functional redundancies, distinct localizations and interactions among three fission yeast homologs of centromere protein-B. (7/99)

Several members of protein families that are conserved in higher eukaryotes are known to play a role in centromere function in the fission yeast Schizosaccharomyces pombe, including two homologs of the mammalian centromere protein CENP-B, Abp1p and Cbh1p. Here we characterize a third S. pombe CENP-B homolog, Cbh2p (CENP-B homolog 2). cbh2Delta strains exhibited a modest elevation in minichromosome loss, similar to cbh1Delta or abp1Delta strains. cbh2Delta cbh1Delta strains showed little difference in growth or minichromosome loss rate when compared to single deletion strains. In contrast, cbh2Delta abp1Delta strains displayed dramatic morphological and chromosome segregation defects, as well as enhancement of the slow-growth phenotype of abp1Delta strains, indicating partial functional redundancy between these proteins. Both cbh2Delta abp1Delta and cbh1Delta abp1Delta strains also showed strongly enhanced sensitivity to a microtubule-destabilizing drug, consistent with a mitotic function for these proteins. Cbh2p was localized to the central core and core-associated repeat regions of centromeric heterochromatin, but not at several other centromeric and arm locations tested. Thus, like its mammalian counterpart, Cbh2p appeared to be localized exclusively to a portion of centromeric heterochromatin. In contrast, Abp1p was detected in both centromeric heterochromatin and in chromatin at two of three replication origins tested. Cbh2p and Abp1p homodimerized in the budding yeast two-hybrid assay, but did not interact with each other. These results suggest that indirect cooperation between different CENP-B-like DNA binding proteins with partially overlapping chromatin distributions helps to establish a functional centromere. (+info)

Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A. (8/99)

The mechanisms that specify precisely where mammalian kinetochores form within arrays of centromeric heterochromatin remain largely unknown. Localization of CENP-A exclusively beneath kinetochore plates suggests that this distinctive histone might direct kinetochore formation by altering the structure of heterochromatin within a sub-region of the centromere. To test this hypothesis, we experimentally mistargeted CENP-A to non-centromeric regions of chromatin and determined whether other centromere-kinetochore components were recruited. CENP-A-containing non-centromeric chromatin assembles a subset of centromere-kinetochore components, including CENP-C, hSMC1, and HZwint-1 by a mechanism that requires the unique CENP-A N-terminal tail. The sequence-specific DNA-binding protein CENP-B and the microtubule-associated proteins CENP-E and HZW10 were not recruited, and neocentromeric activity was not detected. Experimental mistargeting of CENP-A to inactive centromeres or to acentric double-minute chromosomes was also not sufficient to assemble complete kinetochore activity. The recruitment of centromere-kinetochore proteins to chromatin appears to be a unique function of CENP-A, as the mistargeting of other components was not sufficient for assembly of the same complex. Our results indicate at least two distinct steps in kinetochore assembly: (1) precise targeting of CENP-A, which is sufficient to assemble components of a centromere-prekinetochore scaffold; and (2) targeting of kinetochore microtubule-associated proteins by an additional mechanism present only at active centromeres. (+info)

In humans, centromere protein B is encoded by the CENPB gene. Centromere protein B is a highly conserved protein that ... Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. ... Centromere protein B is a potential biomarker of small-cell lung cancer. Centromere GRCh38: Ensembl release 89: ENSG00000125817 ... "Entrez Gene: centromere protein B". Sugimoto K, Yata H, Himeno M (July 1993). "Mapping of the human CENP-B gene to chromosome ...

https://en.wikipedia.org/wiki/Centromere_protein_B

The constitutive proteins include CENPA (centromere protein A), CENPB, CENPC1, and CENPD. The term 'passenger proteins' ... two broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and ' ... Inner centromere protein is a protein that in humans is encoded by the INCENP gene. In mammalian cells, ... "Entrez Gene: INCENP inner centromere protein antigens 135/155kDa". Choo, K. H. Andy (1997). The centromere. Oxford [Oxfordshire ...

https://en.wikipedia.org/wiki/INCENP

Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene. Centromere protein C 1 is a centromere ... 2002). "Mutational analysis of the central centromere targeting domain of human centromere protein C, (CENP-C)". Exp. Cell Res ... 2004). "In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: ... "Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in ...

https://en.wikipedia.org/wiki/CENPC1

Centromere/kinetochore protein zw10 homolog is a protein that in humans is encoded by the ZW10 gene. This gene encodes a ... The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... "Conservation of the centromere/kinetochore protein ZW10". J Cell Biol. 138 (6): 1289-301. doi:10.1083/jcb.138.6.1289. PMC ...

https://en.wikipedia.org/wiki/ZW10

Centromere protein O is a protein that in humans is encoded by the CENPO gene. CENPO is involved in cell proliferation and cell ... "Entrez Gene: CENPO centromere protein O". Hewitt, Chelsee A.; Ling, King-Hwa; Merson, Tobias D.; Simpson, Ken M.; Ritchie, ... 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ...

https://en.wikipedia.org/wiki/CENPO

Centromere protein F is a protein that in humans is encoded by the CENPF gene. It is involved in chromosome segregation during ... the protein forms part of the kinetochore, a disc-shaped protein complex that allows the centromere of two sister chromatids to ... "Entrez Gene: CENPF centromere protein F, 350/400ka (mitosin)". Waters, Aoife M.; Asfahani, Rowan; Carroll, Paula; Bicknell, ... "The cloning and analysis of LEK1 identifies variations in the LEK/centromere protein F/mitosin gene family". J. Biol. Chem. 274 ...

https://en.wikipedia.org/wiki/CENPF

The second is a DNA-binding adaptor protein known as ParR. The last component is a centromere-like region called ParC. The ... The three components, a parC DNA site, and two proteins parR and parM all combine to create the ParMRC system, a type II ... In the cell the ParM protein filaments search for plasmids. Next, they find the ParR and ParC that are headed to DNA molecules ... It has three components: ParM, an actin-like protein that forms a long filament to push two plasmids apart, ParR, which binds ...

https://en.wikipedia.org/wiki/ParMRC_system

Centromere protein H is a protein that in humans is encoded by the CENPH gene. Centromere and kinetochore proteins play a ... "Entrez Gene: CENPH centromere protein H". Fukagawa, T.; Mikami, Y.; Nishihashi, A.; Regnier, V.; Haraguchi, T.; Hiraoka, Y.; ... 2005). "Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy". ... 2007). "Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival ...

https://en.wikipedia.org/wiki/CENPH

Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by ... Centromere protein M is involved in centromere assembly and immune response. GRCh38: Ensembl release 89: ENSG00000100162 - ... "Entrez Gene: CENPM centromere protein M". Brickner AG, Evans AM, Mito JK, Xuereb SM, Feng X, Nishida T, Fairfull L, Ferrell RE ... Overview of all the structural information available in the PDB for UniProt: Q9NSP4 (Human Centromere protein M (CENPM)) at the ...

https://en.wikipedia.org/wiki/CENPM

"Distinct protein interaction domains and protein spreading in a complex centromere". Genes & Development. 14 (7): 783-91. doi: ... Related Protein, Sim3, Binds CENP-A and is Required for Its Deposition at Fission Yeast Centromeres". Molecular Cell. 28 (6): ... Ekwall, K; Javerzat, J. P; Lorentz, A; Schmidt, H; Cranston, G; Allshire, R (1995). "The chromodomain protein Swi6: A key ... Allshire, R. C; Javerzat, J. P; Redhead, N. J; Cranston, G (1994). "Position effect variegation at fission yeast centromeres". ...

https://en.wikipedia.org/wiki/Robin_Allshire

Centromere protein A, also known as CENPA, is a protein which in humans is encoded by the CENPA gene. CENPA is a histone H3 ... "Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated". ... CENPA is a protein which epigenetically defines the position of the centromere on each chromosome, determining the position of ... Uren AG, Wong L, Pakusch M, Fowler KJ, Burrows FJ, Vaux DL, Choo KH (November 2000). "Survivin and the inner centromere protein ...

https://en.wikipedia.org/wiki/CENPA

... proteins are also the autoantigenic target for some anti-nuclear antibodies, such as anti-centromere antibodies. It ... It has been proposed that histone H3 variant CENP-A (Centromere Protein A) is the epigenetic mark of the centromere. The ... There are, broadly speaking, two types of centromeres. "Point centromeres" bind to specific proteins that recognize particular ... Instability of centromere repetitive DNA was recently shown in cancer and aging. When DNA breaks occur at centromeres in the G1 ...

https://en.wikipedia.org/wiki/Centromere

This alternative form is composed of core RFC proteins RFC2, RFC3, RFC4, and RFC5, but replaces the RFC1 protein with cohesion ... High levels of cohesin binding are observed at the centromere. Cohesin is also loaded at cohesin attachment regions (CARs) ... SMC1ß, REC8 and STAG3 are meiosis specific cohesin proteins. The STAG3 protein is essential for female meiosis and fertility. ... The cohesin ring is composed of two SMC (structural maintenance of chromosomes) proteins and two additional Scc proteins. ...

https://en.wikipedia.org/wiki/Establishment_of_sister_chromatid_cohesion

Microtubules attach to the midpoint of chromosomes (the centromere) via protein complexes (kinetochores). The attached ... The centromeres are split, and the sister chromatids are pulled toward the poles by kinetochore microtubules. They take on a V- ... Securin is a protein which inhibits a protease known as separase. The destruction of securin unleashes separase which then ... and by motor proteins such as dyneins or kinesins. Anaphase accounts for approximately 1% of the cell cycle's duration. It ...

https://en.wikipedia.org/wiki/Anaphase

Jiang W, Koltin Y (1996). "Two-hybrid interaction of a human UBC9 homolog with centromere proteins of Saccharomyces cerevisiae ... For example, sumoylation may affect a protein's localization in the cell, its ability to interact with other proteins or DNA. ... SENP proteases can remove SUMO from sumoylated proteins, freeing it to be used in further sumoylation reactions. The protein ... Four alternatively spliced transcript variants encoding the same protein have been found for this gene. The UBC9 protein ...

https://en.wikipedia.org/wiki/UBE2I

1988). "The gene for protein S maps near the centromere of human chromosome 3". Blood. 71 (1): 238-41. doi:10.1182/blood.V71.1. ... Protein S is partly homologous to other vitamin K-dependent plasma coagulation proteins, such as protein C and factors VII, IX ... Dahlbäck B (1991). "Protein S and C4b-binding protein: components involved in the regulation of the protein C anticoagulant ... protein S is encoded by the PROS1 gene. Protein S plays a role in coagulation. Protein S is named for Seattle, Washington, ...

https://en.wikipedia.org/wiki/Protein_S

3-9 encode centromere-associated proteins which complex with the heterochromatin component M31". The EMBO Journal. 18 (7): 1923 ... Chromobox protein homolog 1 is a protein that in humans is encoded by the CBX1 gene. The protein is localized at ... 3-9 encode centromere-associated proteins which complex with the heterochromatin component M31". The EMBO Journal. 18 (7): 1923 ... "The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of ...

https://en.wikipedia.org/wiki/CBX1

Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene. ITGB3BP has been shown to interact with: CD61 ... Talukder AH, Gururaj A, Mishra SK, Vadlamudi RK, Kumar R (2004). "Metastasis-associated protein 1 interacts with NRIF3, an ... "Entrez Gene: ITGB3BP integrin beta 3 binding protein (beta3-endonexin)". Fujimoto TT, Katsutani S, Shimomura T, Fujimura K ( ... PKC theta-dependent protein". J. Cell Biol. 147 (5): 1073-84. doi:10.1083/jcb.147.5.1073. PMC 2169340. PMID 10579726. Ohtoshi A ...

https://en.wikipedia.org/wiki/ITGB3BP

Centromere protein K is a protein that in humans is encoded by the CENPK gene. CENPK has been shown to interact with SOX6. ... "Entrez Gene: CENPK centromere protein K". Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000). "Characterization of Solt, a ... Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa ... Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in ...

https://en.wikipedia.org/wiki/CENPK

Centromere protein J is a protein that in humans is encoded by the CENPJ gene. It is also known as centrosomal P4.1-associated ... "Entrez Gene: CENPJ centromere protein J". Gopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith AH, Megraw TL, Nicastro D, ... Overview of all the structural information available in the PDB for UniProt: Q9HC77 (Centromere protein J) at the PDBe-KB. (All ... Hung LY, Tang CJ, Tang TK (Oct 2000). "Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated ...

https://en.wikipedia.org/wiki/CENPJ

Centromere protein I is a protein that in humans is encoded by the CENPI gene. The product of this gene is involved in the ... "Entrez Gene: CENPI centromere protein I". Thangavelu PU, Lin CY, Vaidyanathan S, Nguyen TH, Dray E, Duijf PH (September 2017 ... Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (February 2004). "Proteomics analysis of the centromere complex from HeLa ... Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673-84. doi ...

https://en.wikipedia.org/wiki/CENPI

CENP‐E, a novel human centromere‐associated protein required for progression from metaphase to anaphase. The EMBO journal. 1991 ... a novel human centromere-associated protein required for progression from metaphase to anaphase". The EMBO Journal. 10 (5): ... As a post-doc in 1991, Tim Yen identified CENP-E, the first mitotic motor protein and found to be essential for progression ... Protein architecture of the human kinetochore microtubule attachment site. Cell. 2009 May 15;137(4):672-84. According to Google ...

https://en.wikipedia.org/wiki/Tim_J._Yen

Centromere protein L is a protein that in humans is encoded by the CENPL gene. GRCh38: Ensembl release 89: ENSG00000120334 - ... "Entrez Gene: CENPL centromere protein L". Human CENPL genome location and CENPL gene details page in the UCSC Genome Browser. ... 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a ... 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human ...

https://en.wikipedia.org/wiki/CENPL

Centromere protein T is a protein that in humans is encoded by the CENPT gene. Mutations in CENPT cause an autosomal recessive ... "Entrez Gene: CENPT centromere protein T". "OMIM Entry - # 618702 - SHORT STATURE AND MICROCEPHALY WITH GENITAL ANOMALIES; SSMGA ... 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a ... 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human ...

https://en.wikipedia.org/wiki/CENPT

Centromere protein N is a protein that in humans is encoded by the CENPN gene. GRCh38: Ensembl release 89: ENSG00000166451 - ... "Entrez Gene: CENPN centromere protein N". Human CENPN genome location and CENPN gene details page in the UCSC Genome Browser. ... 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a ... 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat. ...

https://en.wikipedia.org/wiki/CENPN

Centromere protein U is a protein that in humans is encoded by the CENPU gene. GRCh38: Ensembl release 89: ENSG00000151725 - ... 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a ... 2005). "The Constitutive Centromere Component CENP-50 Is Required for Recovery from Spindle Damage". Mol. Cell. Biol. 25 (23): ... 2007). "MLF1-interacting protein is mainly localized in nucleolus through N-terminal bipartite nuclear localization signal". ...

https://en.wikipedia.org/wiki/MLF1IP

The resulting BLM protein is defective. The defect in RecQ, a helicase, facilitates the defective unwinding of DNA during ... The recombination needs to occur between the centromeres of the adjacent gene. This gives an appearance of yellow patches on ... FRT sites have been inserted transgenically near the centromere of each chromosome arm of D. melanogaster. The FLP gene can ... commonly the green fluorescent protein) and an allele of a gene to be studied (both on chromosomes bearing FRT sites). After ...

https://en.wikipedia.org/wiki/Mosaic_(genetics)

The regulation of transcription factors, effector proteins, molecular chaperones, and cytoskeletal proteins by acetylation and ... Acetylation of histone H4K5 and H4K12ac is enriched at centromeres. H4K5ac indicates acetylation of lysine 5 on histone H4 ... Proteins are typically acetylated on lysine residues and this reaction relies on acetyl-coenzyme A as the acetyl group donor. ... It results in good optimization and is used in vivo to reveal DNA-protein binding occurring in cells. ChIP-Seq can be used to ...

https://en.wikipedia.org/wiki/H4K5ac

Diseases with ATA are autoimmune disease because they react with self-proteins. They are also referred to as anti-DNA ... However, CREST syndrome is more closely associated with anti-centromere antibodies. Scl-70 antibodies are associated with more ... In addition to HLA-DR, the protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (1p13.2 - PTPN22), "CT/TT" genotype ... 2006). "Association of the protein tyrosine phosphatase, non-receptor type 8 R620W polymorphism with anti-topoisomerase I- and ...

https://en.wikipedia.org/wiki/Anti-topoisomerase_antibodies

2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell ... "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 ... "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. ... 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. ...

https://en.wikipedia.org/wiki/DSN1

CENPF codes for centromere protein F. Centromere proteins are involved in the separation of chromosomes during cell division. ... The syndrome is caused by mutations in both copies of the CENPF gene, which codes for centromere protein F. This protein is ... This is through forming part of kinetochores, which are disc-shaped protein complexes that allow the centromeres of chromosomes ... Microtubules are protein structures that are part of the cytoskeleton and are necessary for cells to have diverse, complex ...

https://en.wikipedia.org/wiki/Strømme_syndrome

This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate ... It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor ... Death-associated protein 6 also known as Daxx is a protein that in humans is encoded by the DAXX gene. Daxx, a Death domain- ... DAXX+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) PDBe-KB provides an overview of all ...

https://en.wikipedia.org/wiki/Death-associated_protein_6

... proteins found both in the promoter and coding regions of genes contain specific patterns of hyperacetylation and ... If certain variants stopped functioning, centromeres would not form correctly, genome integrity would be lost, and the DNA ... Histone H2B is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main ... Histone H2B is a lightweight structural protein made of 126 amino acids. Many of these amino acids have a positive charge at ...

https://en.wikipedia.org/wiki/Histone_H2B

... protein - protein biosynthesis - Protein Data Bank - protein design - protein expression - protein folding - protein isoform - ... centromere - centrosome - chaperone - chelation - chemical biology - chemical bond - chemical compound - conformation - ... protein P16 - protein P34cdc2 - protein precursor - protein structure prediction - protein subunit - protein synthesis - ... proto-oncogene protein C-kit - proto-oncogene proteins c-abl - proto-oncogene proteins c-bcl-2 - Proto-oncogene proteins c-fos ...

https://en.wikipedia.org/wiki/Index_of_biochemistry_articles

... encoding protein NIP30 protein NOB1: encoding protein RNA-binding protein NOB1 NOMO1: encoding protein Nodal modulator 1 NPW: ... acen Centromere. var: Variable region; stalk: Stalk. Gilbert F (1999). "Disease genes and chromosomes: disease maps of the ... encoding protein Zinc finger protein 23 ZNF200: encoding protein Zinc finger protein 200 ZNF263: encoding protein Zinc finger ... encoding protein Neuropeptide W NUBP2: encoding protein Nucleotide-binding protein 2 NUPR1: encoding protein Nuclear protein 1 ...

https://en.wikipedia.org/wiki/Chromosome_16

Shugoshin protein is thought to act by protecting two proteins, named Rec8 and Rad21 at the centromeres from protein ... The protein, Shugoshin, is actually Japanese for guardian spirit. Just as its name suggests, the Shugoshin protein guides ... This article incorporates text from the public domain Pfam and InterPro: IPR011516 (Protein pages needing a picture, Protein ... is because it has been observed that the N-terminal fragment was the only part of the protein to localise at the centromere. ...

https://en.wikipedia.org/wiki/Shugoshin_N_terminal_protein_domain

... appears to inhibit the synthesis of the MMP9 protein in vitro in aging skin fibroblasts. An in vivo study in aging ... Epitalon induces decondensation of heterochromatin near the centromeres in cultured lymphocytes originating from samples taken ...

https://en.wikipedia.org/wiki/Epitalon

... which may contribute to the conformational flexibility seen both with and without other bound proteins or protein complexes. A ... mediator appears to be involved in formation or maintenance of heterochromatin at centromeres and telomeres. TGFβ signaling at ... Fungal-specific Protein-name in Sch. pombe Kelleher RJ, Flanagan PM, Kornberg RD (June 1990). "A novel mediator between ... Micro RNAs are involved in regulating the expression of many proteins. Med1 is targeted by miR-1, which is important in gene ...

https://en.wikipedia.org/wiki/Mediator_(coactivator)

... encoding protein Absent in melanoma 1 protein (6q21) AIG1: encoding protein Androgen-induced protein 1 (6q24.2) AKIRIN2: akirin ... acen Centromere. var: Variable region; stalk: Stalk. Notes Some text in this article was taken from http://ghr.nlm.nih.gov/ ... tight junction associated protein 1 (6p21.1) TP53COR1 encoding protein Tumor protein p53 pathway corepressor 1 (non-protein ... encoding protein zinc finger with KRAB and SCAN domains 4 ZNF76: zinc finger protein 76 (6p21.31) ZNF193: zinc finger protein ...

https://en.wikipedia.org/wiki/Chromosome_6

They are counted from the centromere out toward the telomeres. A range of loci is specified in a similar way. For example, the ... the total number of protein-coding genes in a complete haploid set of 23 chromosomes is estimated at 19,000-20,000. Genes may ... "Multiple evidence strands suggest that there may be as few as 19,000 human protein-coding genes". Human Molecular Genetics. 23 ...

https://en.wikipedia.org/wiki/Locus_(genetics)

... and can therefore lead to the evolution of novel protein-coding genes in a process known as de novo gene birth. Exon Promoter ( ... centromeres. They may also contain origins of replication, scaffold attachment regions, and transposons and viruses. Non- ... Genes to Proteins. Jones & Bartlett Learning. ISBN 9780763709167. Alberts, Bruce (2014). Essential Cell Biology (4th ed.). ... "Intergenic ORFs as elementary structural modules of de novo gene birth and protein evolution". Genome Research. 31 (12): 2303- ...

https://en.wikipedia.org/wiki/Intergenic_region

... also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that ... duplication of centromeres or the spindle pole body), and a rise in the S cyclins (Clb5,6 in S. cerevisiae). Clb5,6-Cdk1 ... Cdk1 is comprised mostly by the bare protein kinase motif, which other protein kinases share. Cdk1, like other kinases, ... Cdk1-cyclin complexes are also governed by direct binding of Cdk inhibitor proteins (CKIs). One such protein, already discussed ...

https://en.wikipedia.org/wiki/Cyclin-dependent_kinase_1

... maintenance proteins Microchromosome Y chromosome, §Degeneration Xu, Chunhui; Yu, Weichang (2009). "Engineered ... A minichromosome is a small chromatin-like structure resembling a chromosome and consisting of centromeres, telomeres and ... The minimum constituent parts of a chromosome (centromere, telomeres, and DNA replication sequences) are assembled by using ... centromere, telomeres, and replication sequences), molecular biologists aim to construct a chromosomal platform which can be ...

https://en.wikipedia.org/wiki/Minichromosome

Some of these tags may also allow for increased solubility of the target protein. The target protein is fused to the protein ... Three structural necessities of an artificial chromosome include an origin of replication, a centromere, and telomeric end ... Plasmids used for protein expression, called expression vectors, would include elements for translation of protein, such as a ... Protein purification tags: Some expression vectors include proteins or peptide sequences that allows for easier purification of ...

https://en.wikipedia.org/wiki/Vector_(molecular_biology)

CLIP-associated proteins like CLASP1 in humans have also been shown to localize to plus-ends and the outer kinetochore as well ... at the centromere. While these dynamic rearrangements are vitally important to ensure accurate and high-fidelity segregation of ... The microtubule-associated protein Augmin acts in conjunction with γ-TURC to nucleate new microtubules off of existing ... Microtubule-associated proteins (MAPs) associate with microtubules at the midzone and the spindle poles to regulate their ...

https://en.wikipedia.org/wiki/Spindle_apparatus

Other cytoskeletal proteins and actin binding proteins are involved in the procedure. Plant cells do not perform cytokinesis ... The chromosomes move to opposite poles during anaphase and remain attached to the spindle fibers by their centromeres. Animal ... Cleavage is driven by these motor proteins, actin and myosin, which are the same proteins involved with muscle contraction. ... The same proteins responsible for muscle contraction, actin and myosin, begin the process of forming the cleavage furrow, ...

https://en.wikipedia.org/wiki/Cleavage_furrow

The process can also lead to dicentric or acentric chromosomes (chromosomes with two centromeres or no centromere), which are ... Finally, balancer chromosomes carry dominant genetic markers such as genes for green fluorescent protein or enzymes that make ... which is binding double-stranded RNA and keeping it double-stranded so that it cannot be transcribed into viral proteins. The ...

https://en.wikipedia.org/wiki/Balancer_chromosome

... encoding protein TSC22 domain family protein 1 UBL3: encoding protein Ubiquitin-like protein 3 WBP4: encoding protein WW domain ... acen Centromere. var: Variable region; stalk: Stalk. Wikimedia Commons has media related to Human chromosome 13. National ... encoding protein RCC1 and BTB domain-containing protein 1 RCBTB2: encoding protein RCC1 and BTB domain-containing protein 2 ... encoding protein SLIT and NTRK-like protein 5 SLITRK6: encoding protein SLIT and NTRK-like protein 6 SOX21: Transcription ...

https://en.wikipedia.org/wiki/Chromosome_13

If theHER-2/neu gene does not amplify in the case of polysomy, proteins may be overexpressed and could lead to tumerogenesis. ... Chromosome 17 polysomy may not be present when the centromere is amplified, so it was later discovered that polysomy 17 is rare ... In squamous cell carcinoma, a protein from the epidermal growth factor receptor (EGFR) gene is often overexpressed in ... including fusion of the centromere, or centric fusions. Aneuploidy due to nondisjunction is a common feature in tumor cells. ...

https://en.wikipedia.org/wiki/Polysomy

... protein, and DNA differences and on geographic origin. The two perennials are sympatric and very similar and some consider them ... while most subspecies of section Zea may have none to three knobs between each chromosome end and the centromere and very few ...

https://en.wikipedia.org/wiki/Zea_(plant)

... lack a homologue of the Boule protein that appears to be ubiquitous and conserved in males of all species of other ... Three pairs are metacentric, meaning that the centromere, the attachment point for the spindle fibers in cell division, is ... Though Trichoplax has a small genome in comparison to other animals, nearly 87% of its 11,514 predicted protein-coding genes ... The Trichoplax genome contains about 98 million base pairs and 11,514 predicted protein-coding genes. All nuclei of placozoan ...

https://en.wikipedia.org/wiki/Trichoplax

"A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell ... "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell ... The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late ... ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene. Zwint-1 is clearly involved in kinetochore ...

https://en.wikipedia.org/wiki/ZWINT

The key components of this ring are the filamentous protein actin and the motor protein myosin II. The contractile ring ... allows its translocalization to the central spindle from the centromeres, where it is located during metaphase. Besides being a ... microtubule-bundling protein required for cytokinesis 1) and MKLP1 (a kinesin motor protein). Originally inhibited by CDK1- ... Another protein, septin, has also been speculated to serve as a structural scaffold on which the cytokinesis apparatus is ...

https://en.wikipedia.org/wiki/Cytokinesis

Centromere-specific multi-colour FISH (cenM-FISH) uses the multi-coloured probes from multiplex-FISH as well as centromere ... Pepsin is a protease and acts to digest proteins into peptides. A small volume of the hybridization mixture is placed onto a ... Disrupting these proteins causes telomeric shortening, which can be observed by measuring telomere length with FISH. For ... The relation between centromere abnormalities or chromosomal rearrangements and telomere length may have high clinical impact, ...

https://en.wikipedia.org/wiki/Q-FISH

As a result, each chromosome consists of two sister chromatids held together at the centromere. In the anaphase of mitosis, ... By this combination of lesions, affected cells completely lose expression of functioning tumor suppressor protein. Pre- ... which is located on chromosome 13 and encodes the tumor suppressor retinoblastoma protein, can be detected by cytogenetic ...

https://en.wikipedia.org/wiki/Nondisjunction

RAN binding protein 2 (RANBP2) is protein which in humans is encoded by the RANBP2 gene. It is also known as nucleoporin 358 ( ... "Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha". Cell. 133 (1): 103-15. doi: ... "Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2". Proceedings of the ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi: ...

https://en.wikipedia.org/wiki/RANBP2

One example of an X-linked trait is Coffin-Lowry syndrome, which is caused by a mutation in ribosomal protein gene. This ... A karyotype is picture of all the chromosomes in the metaphase stage arranged according to length and centromere position. A ... It is important that this process occurs otherwise a woman would produce twice the amount of normal X chromosome proteins. The ... and to discover that the human genome was composed of around 20,000 protein coding genes. Medical genetics is the branch of ...

https://en.wikipedia.org/wiki/Human_genetics

protein coding gene. Chr13:100896182-100912415 (-). 129S1/SvImJ MGP_129S1SvImJ_G0020894. protein coding gene. Chr13:102694386- ... protein coding gene. Chr13:100909370-100927500 (-). CBA/J MGP_CBAJ_G0020596. protein coding gene. Chr13:109935921-109955956 (-) ... protein coding gene. Chr13:101729367-101749082 (-). BALB/cJ MGP_BALBcJ_G0020845. protein coding gene. Chr13:99434813-99451429 ... protein coding gene. Chr13:101441831-101457671 (-). C57BL/6NJ MGP_C57BL6NJ_G0021279. protein coding gene. Chr13:105756421- ...

https://www.informatics.jax.org/marker/MGI:1349448

To guarantee faithful chromosomal segregation, there must be a proper assembling of the kinetochore (a protein complex with ... This starts from component protein structures to the prediction of their complexes, preferentially with precision close to ... while validating each modeled structure using orthologs with existing crystal structures from the protein data bank. Results ... Protein-peptide and protein-protein interactions play an essential role in different functional and structural cellular ...

https://bjbas.springeropen.com/articles/10.1186/s43088-022-00285-1

... remaining stably associated with centromeres thereafter. In contrast, C-terminally-tag … ... The budding yeast centromere contains Cse4, a specialized histone H3 variant. Fluorescence pulse-chase analysis of an ... D) Relative fluorescence of Cse4-tdEos centromere clusters in S phase in the absence of protein synthesis. Plateau value ( ... Domain architectures of the Scm3p protein provide insights into centromere function and evolution. Cell Cycle 6:2511-2515. doi ...

https://www.ncbi.nlm.nih.gov/pubmed/24844245&api_key=6850ce796fb3324610d4762dca788159ad08

The 2018 Gordon Research Seminar on Centromere Biology (GRS) will be held in West Dover, VT. Apply today to reserve your spot. ... Genetic Conflicts Shape Centromeres and Centromeric Proteins 4:15 pm - 4:30 pm. Discussion ... The Gordon Research Seminar on Centromere Biology is a unique forum for graduate students, post-docs, and other scientists with ... Centromere and Kinetochore Dynamics / Mentorship Component: Challenges Facing Biomedical Research Discussion Leaders: Sue ...

https://www.grc.org/centromere-biology-grs-conference/2018/

... of a group of interacting proteins called the KAT8 regulatory NSL complex. Learn about this gene and related health conditions. ... The protein produced from the KANSL1 gene is found in most organs and tissues of the body before birth and throughout life. By ... The KANSL1 gene provides instructions for making a member (subunit) of a group of interacting proteins called the KAT8 ... It helps regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into ...

https://medlineplus.gov/genetics/gene/kansl1/

Name: centromere protein C1. Type: Gene. Species: Mus musculus (mouse). Chromosome: 5 ...

https://www.mmrrc.org/catalog/sds.php?mmrrc_id=44343

MeSH Terms: Base Sequence; Centromere Protein B/metabolism; Centromere*; Chromosomal Instability; Chromosomes, Human, Pair 21; ... Abstract: The centromere is the structural unit responsible for the faithful segregation of chromosomes. Although regulation of ... This new approach can thus be used to rapidly take a snapshot of the genetics and epigenetics of each specific human centromere ... We have identified specific markers in the centromere of 23 of the 24 human chromosomes that allow for rapid PCR assays capable ...

https://tools.niehs.nih.gov/portfolio/index.cfm?do=portfolio.publicationDetail&id=3344422

4. Centromere Protein F (. Huang Y; Chen X; Wang L; Wang T; Tang X; Su X. J Cancer; 2021; 12(10):2933-2951. PubMed ID: 33854594 ... Centromere protein F promotes progression of hepatocellular carcinoma through ERK and cell cycle-associated pathways.. Chen H; ... Enhanced expression of centromere protein F predicts clinical progression and prognosis in patients with prostate cancer.. Zhuo ... Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in ...

https://pubmedhh.nlm.nih.gov/biomarkers/search.php?id=35123514&mod=related&page=1&from=&outid=&proj=

Roach, K.C.; Ross, B.D.; Malik, M.S. Rapid evolution of centromeres and centromeric/kinetochore proteins. In Rapidly Evolving ... mRNA and protein breakdown, and RNA and protein chemical modification, and show that all are likely to have evolved through a ... It is important from our point of view that protein components of the meiotic apparatus also show great diversity across these ... Centromeric sequence and proteins evolve rapidly [191], including centromeric variants of otherwise highly conserved chromatin ...

https://www.mdpi.com/2075-1729/6/3/25/htm

A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C.. Kato H, Jiang J, Zhou BR, Rozendaal ... Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein- ... Curr Protoc Protein Sci (2013 Feb) Chapter 20:Unit20.12. Abstract/Full Text. Structural basis for enzyme I inhibition by α- ... Protein Sci (2019 Jun) 28:1059-1070. Abstract/Full Text. KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a ...

https://www.niddk.nih.gov/about-niddk/staff-directory/biography/ghirlando-rodolfo/publications

The major function of protein S is as a cofactor to facilitate the action of activated protein C (APC) on its substrates, ... Protein S is a vitamin K-dependent anticoagulant protein that was first discovered in Seattle, Washington in 1979 and ... The gene for protein S maps near the centromere of human chromosome 3. Blood. 1988 Jan. 71(1):238-41. [QxMD MEDLINE Link]. ... Only free protein S is capable of acting as a cofactor in the protein C system. This distinction between free and total protein ...

https://emedicine.medscape.com/article/205582-overview

... regulation of centromere complex assembly; protein localization to chromosome, centromeric region; negative regulation of ... response to stress; response to unfolded protein; response to heat; positive regulation of protein binding; protein import into ... protein polymerization; de novo posttranslational protein folding; cellular protein metabolic process; neuron differentiation ... protein maturation; chaperone-mediated protein complex assembly; positive regulation of T cell activation; protein ...

https://discover.nci.nih.gov/cellminerdata/html/PROTEIN_RPPA_LIST.html

The telomere binding proteins RAP1 and TRF2 protect telomeres from engaging in homology directed repair (HDR). In this study, ... Fission yeast Srr1 and Skb1 promote isochromosome formation at the centromere Srr1/Ber1 containing the SRR1-like domain and ... Skb1 the human protein arginine methyltransferase 5 (PRMT5) homolog cause gross chromosomal rearrangements at centromeres in ... Combining the information from these structures, they provide new insight in how the RecFOR proteins cooperate to recognize ss- ...

https://www.nature.com/subjects/homologous-recombination?error=cookies_not_supported&code=f5cd1143-8a47-4166-a6bb-f27216bf55b7

Lysates/proteins at 10 µg per lane.. Secondary. All lanes : goat anti-rabbit HRP at 1/2000 dilution. Predicted band size: 143 ... Chromosome , centromere , kinetochore. Associates with chromatin. Before prophase it is scattered along chromosome arms. During ... Proteins and Peptides. By product type. Proteomics tools. Agonists, activators, antagonists and inhibitors. Cell lines and ... The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure. ...

https://www.abcam.com/products/primary-antibodies/smc1a-antibody-ep2879y-ab75819.html?accordion=Documents

Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end- ... Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end- ... Protein concentration was measured using reverse-phase HPLC and the Pierce BCA protein assay kit (Thermo Scientific). The ratio ... Cockayne syndrome B protein is recruited to an actively transcribed damage site, followed by recruitment of replication protein ...

https://www.jbc.org/article/S0021-9258

This CENP-A centromere identifier attracts other proteins, and in cell division builds a massive structure, the kinetochore, ... Those spools are built of histone proteins, and chemical changes to these spool proteins can either loosen or tighten their ... Switching to a protein and fat-rich low-carbohydrate meal can help type 2 diabetes patients control blood sugars, a new study ... This is important because without CENP-A or the centromere mark it creates, the entire chromosome-and all of the genes it ...

https://www.medicaldaily.com/crossroads-chromosomes-penn-study-reveals-structure-cell-divisionaeutms-key-molecule-232886

Each chromosome has one centromere, with one or two arms projecting from the centromere. ... structural proteins, Fig. 1). This composite material (the complex of DNA and protein) is called chromatin. During mitosis ( ... A chromosome is an organized structure of DNA and protein that is found in cells, with each chromosome being a very long, ... 2) Centromere. The point where the two chromatids touch, and where the microtubules attach. (3) Short arm (4) Long arm. ...

https://www.newworldencyclopedia.org/entry/Chromosome

In G2: a cell synthesizes proteins needed for cell division. Checkpoints: control the progression of the cell cycle cells cycle ... Prior to mitosis the chromosomes are replicated forming sister chromatids connected by a centromere Karyotype: a visual display ... Cells that fail to pass the checkpoints may undergo apoptosis( G0) protein p53 can stop cell Mitosis; duplication division that ... Chromatin: chromosomes contain chromatin, chromatin is a combination of proteins and DNA Most human cells are diploid meaning ...

https://www.majortests.com/essay/Nats1675-Final-Exam-523854.html

Producing recombinant Venous CENP-A and polyclinic antibodies against such protein, I will examine by immunofluorescence the ... Producing recombinant Venous CENP-A and polyclinic antibodies against such protein, I will examine by immunofluorescence the ...

https://cordis.europa.eu/project/id/QLK4-CT-2002-51700

Centromere drive and the resulting conflicts between centromere DNA and centromere proteins can generate distinct evolutionary ... "centromere paradox": rapid evolution of both centromere DNA sequences and genes encoding centromere-binding proteins despite ... Thus, centromere DNA and centromere proteins continually evolve in conflict with each other, analogous to a molecular arms race ... Fitness costs associated with centromere drive would also select for alleles of centromere-binding proteins that suppress ...

https://www.nhlbi.nih.gov/science/chromosome-dynamics-and-evolution

Protein structure prediction for the male-specific region of the human Y chromosome. Proc Natl Acad Sci U S A. 2004 Feb 24;101( ... Linear assembly of a human centromere on the Y chromosome. Nat Biotechnol. 2018 Apr;36(4):321-323. doi: 10.1038/nbt.4109. Epub ... The Y chromosome likely contains 70 to 200 genes that provide instructions for making proteins. Because only males have the Y ... Loss of this genetic material likely prevents the production of one or more proteins needed for normal sperm cell development. ...

http://ghr.nlm.nih.gov/chromosome/Y

Additionally, pairs of protein complexes called kinetochores bind to the centromere of each chromosome, one kinetochore for ... Just as DNA is a large molecule constructed of building blocks, microtubules are made of repeating units of protein called ... During G2, proteins are synthesized that will support mitosis and cytokinesis. Additionally, many cell types undergo a kind of ... Chromatin consists of DNA and special proteins called histones. DNA is a long molecule consisting of two strands of repeating ...

https://visionlearning.com/en/library/Biology/2/Cell%20Division%20II/212

CENP-B Protein Centromere Autoantigen 80K Registry Number. 0. See Also. Centromere. Public MeSH Note. 2006; CENTROMERE PROTEIN ... Amino Acids, Peptides, and Proteins [D12] * Proteins [D12.776] * DNA-Binding Proteins [D12.776.260] * Adenovirus E2 Proteins [ ... Amino Acids, Peptides, and Proteins [D12] * Proteins [D12.776] * Nuclear Proteins [D12.776.660] * Chromosomal Proteins, Non- ... Centromere Protein B Preferred Concept UI. M0147025. Registry Number. 0. Scope Note. A DNA-binding protein that interacts with ...

https://meshb.nlm.nih.gov/record/ui?ui=D051936

... and protein molecules are highly organized within three-dimensional (3D) structures in the nucleus. Although RNA has been ... Individual centromeres assemble into a heterochromatic chromocenter structure highly enriched with HP1 protein. See also Figure ... D) Imaging of snoRNA, scaRNA, or NPAT protein upon ActD or DMSO treatment. Scalebar is 10μm. (E) RNA-DNA contacts upon DMSO ( ... RNA, DNA, and protein molecules are highly organized within three-dimensional (3D) structures in the nucleus. Although RNA has ...

https://pubmed.ncbi.nlm.nih.gov/34739832/

... or protein complex (e.g. ORC), and an easily unwound sequence ... one or more binding sites for an origin recognition protein (e. ... The D 9 element neither binds ORC nor functions as a centromere, but does bind an as yet unidentified protein throughout the ... neither binds ORC nor functions as a centromere, although it does bind an as yet unidentified protein throughout the cell cycle ... epitope tagged proteins, we will to purify protein-DNA complexes that exist in human cells during normal cell proliferation. We ...

https://www.nichd.nih.gov/about/org/dir/affinity-groups/BMGR/depamphilis/research/DNA-replication

What the Karpen team previously found in fruit flies is that the overexpression of a specific centromere protein resulted in ... To determine if centromeres play a role in chromosome instability in human cancers, the researchers analyzed many public ... The centromeres and kinetochores of a chromosome play critical roles during cell division. In mitosis, microtubule spindle ... "This essentially makes new centromeres functional at more than one place on the chromosome, and this is a huge problem because ...

https://newscenter.lbl.gov/2016/08/31/biomarker-for-cancer-patient-prognosis/

His labs longest standing goal has been to understand how particular proteins at the centromere direct accurate chromosome ... and whether machine learning can predict protein-protein interaction networks. ... His team defined the epigenetic centromere mark to be an octameric nucleosome containing the histone H3 variant, CENP-A, and ... The goal of her lab is to define how protein trafficking pathways can be modulated to impact neurodegeneration, by examining ...

http://commonfund.nih.gov/tra/recipients21

It helps regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into chromosomes. (medlineplus.gov)
The centromere is the structural unit responsible for the faithful segregation of chromosomes. (nih.gov)
We have identified specific markers in the centromere of 23 of the 24 human chromosomes that allow for rapid PCR assays capable of capturing the genomic landscape of human centromeres at a given time. (nih.gov)
In the chromosomes of eukaryotes , the uncondensed DNA exists in a quasi-ordered structure inside the nucleus, where it wraps around histones (structural proteins, Fig. 1). (newworldencyclopedia.org)
Microtubules are self-assembled from dimers of alpha and beta tubulin (a globular protein), and attach to chromosomes at specialized structures called the kinetochores, one of which is present on each sister chromatid. (newworldencyclopedia.org)
Centromeres incorporate both MT-binding and counteracting MT-destabilizing activities: the former attaches chromosomes to the spindle, and the latter promotes re-orientation of incorrect attachments to prevent segregation errors. (nih.gov)
The study authors focused on genes regulating the function of centromeres and kinetochores - the essential sites on chromosomes that spindle fibers attach to during cell division - based upon results from earlier research by the Karpen group and other labs in the field. (lbl.gov)
What the Karpen team previously found in fruit flies is that the overexpression of a specific centromere protein resulted in extra spindle attachment sites on the chromosomes. (lbl.gov)
The new DNA sequences, among other things, provide previously unknown details about the area around the centromere, which is where chromosomes are seized and tugged apart as cells split, ensuring that each "daughter" cell acquires the right amount of chromosomes. (scitechdaily.com)
The consortium's gapless version of all 22 autosomes and the X sex chromosome is composed of 3.055 billion base pairs, the units from which chromosomes and our genes are built, and 19,969 protein-coding genes. (scitechdaily.com)
Altemose's main research involves finding and exploring areas of the chromosomes where proteins interact with DNA. (scitechdaily.com)
The spindles (green) that pull chromosomes apart during cell division are attached to a protein complex called the kinetochore, which latches onto the chromosome at a place called the centromere - a region containing highly repetitive DNA sequences. (scitechdaily.com)
The findings, publishing in the February 28, 2019 issue of Developmental Cell , focus on the dynamic coupling of microtubule ends to kinetochores, built on the centromeres of chromosomes, to direct chromosome segregation during cell division. (ucsd.edu)
During cell division or mitosis, the centromere regions of chromosomes assemble large protein machines called kinetochores to connect chromosomes to microtubules, which the chromosomes then use to separate to opposite ends of the cell. (ucsd.edu)
The dynamically growing mitotic spindle attaches to chromosomes at the kinetochore, a network of scaffolding and signalling proteins located at the centromere of each chromosome (burgundy arrows). (garvan.org.au)
ATRX is a protein that binds to the centromere of all chromosomes in every single cell of the body, but when it malfunctions, chromosomes cannot segregate properly and lose their structural integrity. (uga.edu)

Kinetochores become established on a part of the centromere (specialized chromatin), with the presence of CENP-A (a variant of histone H3) as a major hallmark [ 8 ]. (springeropen.com)
A special DNA base sequence in the region of the kinetochores provides, along with special proteins, longer-lasting attachment in this region. (newworldencyclopedia.org)
The centromeres and kinetochores of a chromosome play critical roles during cell division. (lbl.gov)

By its involvement in controlling the activity of other genes, this protein plays an important role in the development and function of many parts of the body. (medlineplus.gov)
18. Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic Analysis. (nih.gov)
A chromosome is an organized structure of DNA and protein that is found in cells, with each chromosome being a very long, continuous, single piece of double-stranded DNA (a single DNA molecule) containing many genes , regulatory elements and other nucleotide sequences. (newworldencyclopedia.org)
The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)
The Y chromosome likely contains 70 to 200 genes that provide instructions for making proteins. (nih.gov)
Genes in these regions provide instructions for making proteins thought to be involved in sperm cell development, although the specific functions of these proteins are unknown. (nih.gov)
Meiotic drive of selfish centromeres, or centromere drive, can explain the "centromere paradox": rapid evolution of both centromere DNA sequences and genes encoding centromere-binding proteins despite conserved centromere function in segregation. (nih.gov)
Researchers have linked the overexpression of centromere and kinetochore genes to cancer patient outcome after adjuvant therapies. (lbl.gov)
Shown back to front, Berkeley Lab's Gary Karpen (standing), Weiguo Zhang and Jian-Hua Mao examine data on centromere and kinetochore genes. (lbl.gov)
Of the protein-coding genes, the T2T team found about 2,000 new ones, most of them disabled, but 115 of which may still be expressed. (scitechdaily.com)

This gene encodes a component of the interphase centromere complex. (nih.gov)
The protein is a component of the nuclear matrix during the G2 phase of interphase. (utsouthwestern.edu)

Although regulation of centromeric function by epigenetic factors has been well-studied, the contributions of the underlying DNA sequences have been much less well defined, and existing methodologies for studying centromere genomics in biology are laborious. (nih.gov)
Use of this genetic strategy can also delineate which specific centromere arrays in each chromosome drive the recruitment of epigenetic modulators. (nih.gov)
How conserved the underlying mechanisms driving the epigenetic phenomenon of centromere and kinetochore assembly and maintenance are remains unclear, even though various eukaryotic models have been studied. (oregonstate.edu)
The team has been studying the role of chromatin remodeling proteins in the epigenetic control of chromosome instability for many years, and it's no small task to capture these images and analyze the data. (uga.edu)

Kinase and phosphatase proteins that orchestrate multiple phosphoevents are represented as white tracks. (garvan.org.au)
Decreased expression of six RNA species was seen at various time points in all cell strains analyzed, these were: plasminogen activator (PLAT), centromere protein F (CPF), replication factor C (RFC3), thymidylate synthetase (TYMS), a putative mitotic checkpoint kinase (BUB1) and a gene of unknown function (GenBank accession number AI859865). (cdc.gov)

His lab's longest standing goal has been to understand how particular proteins at the centromere direct accurate chromosome segregation at mitosis and meiosis. (nih.gov)
The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. (nih.gov)

Centromeres direct chromosome segregation, and therefore are the genetic elements with the best opportunity to cheat the segregation process. (nih.gov)

Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N. (nih.gov)
Molecular basis of CENP-C association with the CENP-A nucleosome at yeast centromeres. (nih.gov)
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. (nih.gov)

Producing recombinant Venous CENP-A and polyclinic antibodies against such protein, I will examine by immunofluorescence the possible role of HIRA in chromatin assembly that could be involved in the centromeric structure. (europa.eu)

The inner kinetochore on the other hand serves as a host for the CCAN (constitutive centromere-associated network), a complex consisting of sixteen different centromeric proteins (CENPs) [ 12 ], most of which were identified originally in the vertebrates' CENP-A interactome [ 13 ]. (springeropen.com)
The kinetochore (centromeric DNA and associated proteins) is essential for faithful chromosome segregation. (nih.gov)

an assembly consisting of ten protein subunits that act as a microtubule receptor [ 10 , 11 ]. (springeropen.com)

To determine if centromeres play a role in chromosome instability in human cancers, the researchers analyzed many public datasets from the National Center for Biotechnology Information, the Broad Institute and other organizations that together contained thousands of human clinical tumor samples from at least a dozen types of cancers. (lbl.gov)

Protein-peptide and protein-protein interactions play an essential role in different functional and structural cellular organizational aspects. (springeropen.com)
Although molecular and cell biology have made huge advancements toward the delivery of powerful methodologies for the discovery and identification of protein-protein interactions, likewise their subcellular localization, structural biology alone is able to give definite answers regarding interaction mechanisms through the uncovering of atomistic and high-resolution structures of the underlying complexes [ 1 ]. (springeropen.com)
By contrast, computational structural biology has the potential to generate protein-protein interaction models of high resolution [ 5 ]. (springeropen.com)
Here we report that Pat1, an evolutionarily conserved protein, is a structural component of budding yeast kinetochore. (nih.gov)

This new approach can thus be used to rapidly take a snapshot of the genetics and epigenetics of each specific human centromere in nondisjunction disorders and other biological settings. (nih.gov)

Previous studies in an attempt to understand the assembly and mechanism devised by the CENP-HIKM in promoting the functionality of the kinetochore have reconstituted the protein complex from different organisms including fungi and yeast. (springeropen.com)
Here the authors report that the yeast ubiquitin E3 ligase Bre1 and its human homolog RNF20 function as recombination mediator proteins by promoting Rad51-ssDNA assembly, Rad51 replacement of ssDNA-bound RPA while antagonizing the activities of Srs2 or FBH1 anti-recombinase. (nature.com)

Pat1 interacts with kinetochore protein Scm3 in vivo, and associates with centromeres in the presence of a functional kinetochore. (nih.gov)

This gene encodes a protein that associates with the centromere-kinetochore complex. (utsouthwestern.edu)

Protein S is part of a system of anticoagulant proteins that regulate normal coagulation mechanisms in the body. (medscape.com)

In addition, origin activity can be regulated from sequences such as "locus control regions" that are many kilobases distal to the OBR but affect the accessibility of initiation sites to replication proteins. (nih.gov)

It is located around the centromere and usually contains repetitive sequences. (newworldencyclopedia.org)
The centromere drive theory is based on the idea that natural selection favors centromere DNA sequences that act selfishly in female meiosis. (nih.gov)
Altemose is first author of one paper that describes the base pair sequences around the centromere. (scitechdaily.com)
A paper explaining how the sequencing was done will appear in the April 1 print edition of the journal Science , while Altemose's centromere paper and four others describing what the new sequences tell us are summarized in the journal with the full papers posted online. (scitechdaily.com)
The new DNA sequences in and around the centromere total about 6.2% of the entire genome, or nearly 190 million base pairs, or nucleotides. (scitechdaily.com)
Repeats in the active centromere tend to be the youngest and most recently duplicated sequences in the region, and they have strikingly low DNA methylation. (scitechdaily.com)

Srr1/Ber1 containing the SRR1-like domain and Skb1 the human protein arginine methyltransferase 5 (PRMT5) homolog cause gross chromosomal rearrangements at centromeres in the absence of Rad51 recombinase. (nature.com)

Here we observed that the HR repair protein RAD52 is recruited to sites of DNA DSBs in terminally differentiated, post-mitotic neurons. (jbc.org)
NEBD is driven by phosphorylation of nuclear pore and lamin proteins, combined with physical disruption by the growing mitotic spindle. (garvan.org.au)

11. Centromere protein F promotes progression of hepatocellular carcinoma through ERK and cell cycle-associated pathways. (nih.gov)
16. Enhanced expression of centromere protein F predicts clinical progression and prognosis in patients with prostate cancer. (nih.gov)

The major function of protein S is as a cofactor to facilitate the action of activated protein C (APC) on its substrates, activated factor V (FVa) and activated factor VIII (FVIIIa). (medscape.com)
Protein S functions predominantly as a nonenzymatic cofactor for the action of another anticoagulant protein, activated protein C (APC). (medscape.com)
APC requires protein S as a cofactor in its enzymatic action on its 2 substrates, FVa and FVIIIa. (medscape.com)
Thus, this process is designed to dampen and shut off clotting by switching off the key cofactor proteins FVa and FVIIIa. (medscape.com)

We and others have shown that they consist of binding sites for transcription factors that facilitate either binding of origin recognition proteins or DNA unwinding (3). (nih.gov)

This meeting will focus on the dynamic properties of centromeres, from an evolutionary and a cellular perspective. (grc.org)
Centromere drive and the resulting conflicts between centromere DNA and centromere proteins can generate distinct evolutionary trajectories in different populations, explaining the large divergence in centromere DNA even between closely-related species or strains. (nih.gov)

The entire genome is made of just four types of nucleotides, which, in groups of three, code for the amino acids used to build proteins. (scitechdaily.com)

First, we showed that centromeres with expanded satellite repeats act selfishly to preferentially orient towards the egg pole of the meiotic spindle to remain in the egg (Fig. 1 and 2A). (nih.gov)

The KANSL1 gene provides instructions for making a member (subunit) of a group of interacting proteins called the KAT8 regulatory NSL complex. (medlineplus.gov)
The COPII subunit, Sec31 , and ER exit site protein, Sec16 , are critical for subcellular tube architecture, whereas the SNARE proteins Syntaxin 5 , Syntaxin 1 and Syntaxin 18 are more generally required for seamless tube growth and maintenance. (sdbonline.org)

This essentially makes new centromeres functional at more than one place on the chromosome, and this is a huge problem because the spindle tries to connect to all the sites," said Karpen. (lbl.gov)

Here, we present a detailed computational model of the physical interactions that exist between each component of the human CENP-HIKM, while validating each modeled structure using orthologs with existing crystal structures from the protein data bank. (springeropen.com)

The telomere binding proteins RAP1 and TRF2 protect telomeres from engaging in homology directed repair (HDR). (nature.com)

Genetic interaction study shows that Drice mediates its action by regulating Rho1GTPase functionally, and localization of polarity protein Disc large . (sdbonline.org)
Chromosome segregation relies on coordinated activity of a large assembly of proteins, the kinetochore interaction network (KIN). (oregonstate.edu)
May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. (nih.gov)

Rapid molecular assays to study human centromere genomics. (nih.gov)
Abrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin I. (nih.gov)
Residue numbering on these phosphosites refer to human proteins. (garvan.org.au)

The Gordon Research Seminar on Centromere Biology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. (grc.org)
This GRS will be held in conjunction with the "Centromere Biology" Gordon Research Conference (GRC). (grc.org)

Together, these findings provided first insights into how selfish mouse centromeres exploit the inherent asymmetry in female meiosis to challenge Mendel. (nih.gov)

This composite material (the complex of DNA and protein) is called chromatin. (newworldencyclopedia.org)

This starts from component protein structures to the prediction of their complexes, preferentially with precision close to complex structures generated by X-ray crystallography. (springeropen.com)

Because we removed ATRX protein expression only in the oocyte, the female egg cell, we can now study its function at both the cellular and molecular level. (uga.edu)

Topics will span a variety of organisms and will include changes in centromere function and composition across the cell division cycle, and highlight emerging methods and areas of interest in the field. (grc.org)
To understand how thrombosis occurs in protein S deficiency, its physiological function should be briefly reviewed. (medscape.com)
The image below shows a simplified outline of the function of protein S in the protein C system. (medscape.com)
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)

Thus, centromere DNA and centromere proteins continually evolve in conflict with each other, analogous to a molecular arms race between viruses and the immune system. (nih.gov)

These two large proteins are homologous in structure and are cofactors, not enzymes, in the clotting process. (medscape.com)

Thrombosis is observed in both heterozygous and homozygous genetic deficiencies of protein S. (medscape.com)
Loss of this genetic material likely prevents the production of one or more proteins needed for normal sperm cell development. (nih.gov)

Next, we explored the effect of STM2457 on METTL3 and revealed its effects on the inhibition of catalytic activity and upregulation of METTL3 protein expression. (bvsalud.org)

A DNA-binding protein that interacts with a 17-base pair sequence known as the CENP-B box motif. (nih.gov)

The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. (utsouthwestern.edu)

We and others have shown that they consist of two essential components (1) : one or more binding sites for an origin recognition protein (e.g. (nih.gov)

The protein is localized constitutively to the CENTROMERE and plays an important role in its maintenance. (nih.gov)

Anatomy3

Chemicals and Drugs8

Phenomena and Processes6

Extreme reduction of chromosome-specific alpha-satellite array is unusually common in human chromosome 21. (1/99)

Uterine dysfunction and genetic modifiers in centromere protein B-deficient mice. (2/99)

Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice. (3/99)

Fission yeast homologs of human CENP-B have redundant functions affecting cell growth and chromosome segregation. (4/99)

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. (5/99)

Centromere/kinetochore localization of human centromere protein A (CENP-A) exogenously expressed as a fusion to green fluorescent protein. (6/99)

Functional redundancies, distinct localizations and interactions among three fission yeast homologs of centromere protein-B. (7/99)

Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A. (8/99)

No images available that match "centromere protein b"

Centromere Protein B

Centromere

Chromosomal Proteins, Non-Histone

Autoantigens

Kinetochores

Pulmonary Surfactant-Associated Protein B

Chromosome Segregation

Mitosis

Aurora Kinase B

Aurora Kinases

DNA, Satellite

Chromosomes

Transferrin-Binding Protein B

Extreme reduction of chromosome-specific alpha-satellite array is unusually common in human chromosome 21. (1/99)

Uterine dysfunction and genetic modifiers in centromere protein B-deficient mice. (2/99)

Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice. (3/99)

Fission yeast homologs of human CENP-B have redundant functions affecting cell growth and chromosome segregation. (4/99)

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. (5/99)

Centromere/kinetochore localization of human centromere protein A (CENP-A) exogenously expressed as a fusion to green fluorescent protein. (6/99)

Functional redundancies, distinct localizations and interactions among three fission yeast homologs of centromere protein-B. (7/99)

Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A. (8/99)

Centromere protein B

INCENP

CENPC1

ZW10

CENPO

CENPF

ParMRC system

CENPH

CENPM

Robin Allshire

CENPA

Centromere

Establishment of sister chromatid cohesion

Anaphase

UBE2I

Protein S

CBX1

ITGB3BP

CENPK

CENPJ

CENPI

Tim J. Yen

CENPL

CENPT

CENPN

MLF1IP

Mosaic (genetics)

H4K5ac

Anti-topoisomerase antibodies

DSN1

Strømme syndrome

Death-associated protein 6

Histone H2B

Index of biochemistry articles

Chromosome 16

Shugoshin N terminal protein domain

Epitalon

Mediator (coactivator)

Chromosome 6

Locus (genetics)

Intergenic region

Cyclin-dependent kinase 1

Minichromosome

Vector (molecular biology)

Spindle apparatus

Cleavage furrow

Balancer chromosome

Chromosome 13

Polysomy

Zea (plant)

Trichoplax

ZWINT

Cytokinesis

Q-FISH

Nondisjunction

RANBP2

Human genetics

Cenph MGI Mouse Gene Detail - MGI:1349448 - centromere protein H

Computer-aided molecular modeling and structural analysis of the human centromere protein-HIKM complex | Beni-Suef University...