AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth CareGeographicals
CentriolesCentrosomeOrganoidsCiliaMicrotubulesMitosisSpindle ApparatusTubulinCell Cycle ProteinsChlamydomonasOrofaciodigital SyndromesCell CycleMicroscopy, ElectronSpermatocytesAxonemeMicrotubule-Associated ProteinsFlagellaMicrotubule ProteinsHistology, ComparativeProtein-Serine-Threonine KinasesHeLa CellsSpermatozoaProphaseDemecolcineInterphaseNational Heart, Lung, and Blood Institute (U.S.)National Institutes of Health (U.S.)Adolescent MedicineGovernment Publications as TopicReference BooksBibliography as TopicUnited StatesEncyclopedias as TopicBotanyZoologyPhysician-Nurse RelationsPhysiologyEducational MeasurementAnatomy
Centrioles
Self-replicating, short, fibrous, rod-shaped organelles. Each centriole is a short cylinder containing nine pairs of peripheral microtubules, arranged so as to form the wall of the cylinder.
Centrosome
The cell center, consisting of a pair of CENTRIOLES surrounded by a cloud of amorphous material called the pericentriolar region. During interphase, the centrosome nucleates microtubule outgrowth. The centrosome duplicates and, during mitosis, separates to form the two poles of the mitotic spindle (MITOTIC SPINDLE APPARATUS).
Organoids
An organization of cells into an organ-like structure. Organoids can be generated in culture. They are also found in certain neoplasms.
Cilia
Populations of thin, motile processes found covering the surface of ciliates (CILIOPHORA) or the free surface of the cells making up ciliated EPITHELIUM. Each cilium arises from a basic granule in the superficial layer of CYTOPLASM. The movement of cilia propels ciliates through the liquid in which they live. The movement of cilia on a ciliated epithelium serves to propel a surface layer of mucus or fluid. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Microtubules
Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.
Mitosis
A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.
Spindle Apparatus
A microtubule structure that forms during CELL DIVISION. It consists of two SPINDLE POLES, and sets of MICROTUBULES that may include the astral microtubules, the polar microtubules, and the kinetochore microtubules.
Tubulin
A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.
Cell Cycle Proteins
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
Chlamydomonas
A genus GREEN ALGAE in the order VOLVOCIDA. It consists of solitary biflagellated organisms common in fresh water and damp soil.
Orofaciodigital Syndromes
Two syndromes of oral, facial, and digital malformations. Type I (Papillon-Leage and Psaume syndrome, Gorlin-Psaume syndrome) is inherited as an X-linked dominant trait and is found only in females and XXY males. Type II (Mohr syndrome) is inherited as an autosomal recessive trait.
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Microscopy, Electron
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Spermatocytes
Male germ cells derived from SPERMATOGONIA. The euploid primary spermatocytes undergo MEIOSIS and give rise to the haploid secondary spermatocytes which in turn give rise to SPERMATIDS.
Axoneme
A bundle of MICROTUBULES and MICROTUBULE-ASSOCIATED PROTEINS forming the core of each CILIUM or FLAGELLUM. In most eukaryotic cilia or flagella, an axoneme shaft has 20 microtubules arranged in nine doublets and two singlets.
Microtubule-Associated Proteins
High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.
Flagella
A whiplike motility appendage present on the surface cells. Prokaryote flagella are composed of a protein called FLAGELLIN. Bacteria can have a single flagellum, a tuft at one pole, or multiple flagella covering the entire surface. In eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella have the same basic structure as CILIA but are longer in proportion to the cell bearing them and present in much smaller numbers. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
Microtubule Proteins
Proteins found in the microtubules.
Histology, Comparative
The study of the similarities and differences in the structures of homologous tissues across various species.
Protein-Serine-Threonine Kinases
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
HeLa Cells
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
Spermatozoa
Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.
Prophase
The first phase of cell nucleus division, in which the CHROMOSOMES become visible, the CELL NUCLEUS starts to lose its identity, the SPINDLE APPARATUS appears, and the CENTRIOLES migrate toward opposite poles.
Demecolcine
An alkaloid isolated from Colchicum autumnale L. and used as an antineoplastic.
Interphase
The interval between two successive CELL DIVISIONS during which the CHROMOSOMES are not individually distinguishable. It is composed of the G phases (G1 PHASE; G0 PHASE; G2 PHASE) and S PHASE (when DNA replication occurs).
National Heart, Lung, and Blood Institute (U.S.)
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research program related to diseases of the heart, blood vessels, lung, and blood; blood resources; and SLEEP WAKE DISORDERS. From 1948 until October 10, 1969, it was known as the National Heart Institute. From June 25, 1976, it was the National Heart and Lung Institute. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman's Health Initiative.
National Institutes of Health (U.S.)
An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.
Adolescent Medicine
A branch of medicine pertaining to the diagnosis and treatment of diseases occurring during the period of ADOLESCENCE.
Government Publications as Topic
Discussion of documents issued by local, regional, or national governments or by their agencies or subdivisions.
Reference Books
Books designed by the arrangement and treatment of their subject matter to be consulted for definite terms of information rather than to be read consecutively. Reference books include DICTIONARIES; ENCYCLOPEDIAS; ATLASES; etc. (From the ALA Glossary of Library and Information Science, 1983)
Bibliography as Topic
Discussion of lists of works, documents or other publications, usually with some relationship between them, e.g., by a given author, on a given subject, or published in a given place, and differing from a catalog in that its contents are restricted to holdings of a single collection, library, or group of libraries. (from The ALA Glossary of Library and Information Science, 1983)
United States
Encyclopedias as Topic
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Botany
The study of the origin, structure, development, growth, function, genetics, and reproduction of plants.
Zoology
The study of animals - their morphology, growth, distribution, classification, and behavior.
Physician-Nurse Relations
The reciprocal interaction of physicians and nurses.
Physiology
The biological science concerned with the life-supporting properties, functions, and processes of living organisms or their parts.
Educational Measurement
The assessing of academic or educational achievement. It includes all aspects of testing and test construction.
Anatomy
A branch of biology dealing with the structure of organisms.

Influence of centriole behavior on the first spindle formation in zygotes of the brown alga Fucus distichus (Fucales, Phaeophyceae). (1/575)

The influence of centrioles, derived from the sperm flagellar basal bodies, and the centrosomal material (MTOCs) on spindle formation in the brown alga Fucus distichus (oogamous) was studied by immunofluorescence microscopy using anti-centrin and anti-beta-tubulin antibodies. In contrast to a bipolar spindle, which is formed after normal fertilization, a multipolar spindle was formed in polyspermic zygote. The number of mitotic poles in polyspermic zygotes was double the number of sperm involved in fertilization. As an anti-centrin staining spot (centrioles) was located at these poles, the multipolar spindles in polyspermic zygotes were produced by the supplementary centrioles. When anucleate egg fragments were fertilized, chromosome condensation and mitosis did not occur in the sperm nucleus. Two anti-centrin staining spots could be detected, microtubules (MTs) radiated from nearby, but the mitotic spindle was never produced. When a single sperm fertilized multinucleate eggs (polygyny), abnormal spindles were also observed. In addition to two mitotic poles containing anti-centrin staining spots, extra mitotic poles without anti-centrin staining spots were also formed, and as a result multipolar spindles were formed. When karyogamy was blocked with colchicine, it became clear that the egg nucleus proceeded independently into mitosis accompanying chromosome condensation. A monoastral spindle could be frequently observed, and in rare cases a barrel-shaped spindle was formed. However, when a sperm nucleus was located near an egg nucleus, the two anti-centrin staining spots shifted to the egg nucleus from the sperm nucleus. In this case, a normal spindle was formed, the egg chromosomes arranged at the equator, and the associated MTs elongated from one pole of the egg spindle toward the sperm chromosomes which were scattered. From these results, it became clear that paternal centrioles derived from the sperm have a crucial role in spindle formation in the brown algae, such as they do during animal fertilization. However, paternal centrioles were not adequate for the functional centrosome during spindle formation. We speculated that centrosomal materials from the egg cytoplasm aggregate around the sperm centrioles and are needed for centrosomal activation.  (+info)

Cell division: The renaissance of the centriole. (2/575)

Centrioles are located at the center of the cytoskeleton and duplicate exactly once per cell cycle. Recent studies suggest that centrioles are required for the organization of a functional centrosome and that centriole assembly requires both gamma- and delta-tubulin.  (+info)

Rab15 mediates an early endocytic event in Chinese hamster ovary cells. (3/575)

Rab GTPases comprise a large family of monomeric proteins that regulate a diverse number of membrane trafficking events, including endocytosis. In this paper, we examine the subcellular distribution and function of the GTPase Rab15. Our biochemical and confocal immunofluorescence studies demonstrate that Rab15 associates with the transferrin receptor, a marker for the early endocytic pathway, but not with Rab7 or the cation-independent mannose 6-phosphate receptor, markers for late endosomal membranes. Furthermore, Rab15 colocalizes with Rab4 and -5 on early/sorting endosomes, as well as Rab11 on pericentriolar recycling endosomes. Consistent with its localization to early endosomal membranes, overexpression of the constitutively active mutant HArab15Q67L reduces receptor-mediated and fluid phase endocytosis. Therefore, our functional studies suggest that Rab15 may function as an inhibitory GTPase in early endocytic trafficking.  (+info)

Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle. (4/575)

Centrosomes organize the mitotic spindle to ensure accurate segregation of the chromosomes in mitosis. The mechanism that ensures accurate duplication and separation of the centrosomes underlies the fidelity of chromosome segregation, but remains unknown. In Saccharomyces cerevisiae, entry into S phase and separation of spindle pole bodies each require CDC4 and CDC34, which encode components of an SCF (Skp1-cullin-F-box) ubiquitin ligase, but a direct (SCF) connection to the spindle pole body is unknown. Using immunofluorescence microscopy, we show that in mammalian cells the Skp1 protein and the cullin Cul1 are localized to interphase and mitotic centrosomes and to the cytoplasm and nucleus. Deconvolution and immunoelectron microscopy suggest that Skp1 forms an extended pericentriolar structure that may function to organize the centrosome. Purified centrosomes also contain Skp1, and Cul1 modified by the ubiquitin-like molecule NEDD8, suggesting a role for NEDD8 in targeting. Using an in vitro assay for centriole separation in Xenopus extracts, antibodies to Skp1 or Cul1 block separation. Proteasome inhibitors block both centriole separation in vitro and centrosome duplication in Xenopus embryos. We identify candidate centrosomal F-box proteins, suggesting that distinct SCF complexes may direct proteolysis of factors mediating multiple steps in the centrosome cycle.  (+info)

Tubulin polyglutamylase: isozymic variants and regulation during the cell cycle in HeLa cells. (5/575)

Polyglutamylation is a posttranslational modification of tubulin that is very common in neurons and ciliated or flagellated cells. It was proposed to regulate the binding of microtubule associated proteins (MAPs) and molecular motors as a function of the length of the polyglutamyl side-chain. Though much less common, this modification of tubulin also occurs in proliferating cells like HeLa cells where it is associated with centrioles and with the mitotic spindle. Recently, we partially purified tubulin polyglutamylase from mouse brain and described its enzymatic properties. In this work, we focused on tubulin polyglutamylase activity from HeLa cells. Our results support the existence of a tubulin polyglutamylase family composed of several isozymic variants specific for alpha- or beta-tubulin subunits. In the latter case, the specificity probably also concerns the different beta-tubulin isotypes. Interestingly, we found that tubulin polyglutamylase activity is regulated in a cell cycle dependent manner and peaks in G(2)-phase while the level of glutamylated tubulin peaks in mitosis. Consistent results were obtained by treating the cells with hydroxyurea, nocodazole or taxotere. In particular, in mitotic cells, tubulin polyglutamylase activity was always low while glutamylation level was high. Finally, tubulin polyglutamylase activity and the level of glutamylated tubulin appeared to be inversely related. This paradox suggests a complex regulation of both tubulin polyglutamylase and the reverse deglutamylase activity.  (+info)

Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis. (6/575)

We identified Xenopus pericentriolar material-1 (PCM-1), which had been reported to constitute pericentriolar material, cloned its cDNA, and generated a specific pAb against this molecule. Immunolabeling revealed that PCM-1 was not a pericentriolar material protein, but a specific component of centriolar satellites, morphologically characterized as electron-dense granules, approximately 70-100 nm in diameter, scattered around centrosomes. Using a GFP fusion protein with PCM-1, we found that PCM-1-containing centriolar satellites moved along microtubules toward their minus ends, i.e., toward centrosomes, in live cells, as well as in vitro reconstituted asters. These findings defined centriolar satellites at the molecular level, and explained their pericentriolar localization. Next, to understand the relationship between centriolar satellites and centriolar replication, we examined the expression and subcellular localization of PCM-1 in ciliated epithelial cells during ciliogenesis. When ciliogenesis was induced in mouse nasal respiratory epithelial cells, PCM-1 immunofluorescence was markedly elevated at the apical cytoplasm. At the electron microscopic level, anti-PCM-1 pAb exclusively labeled fibrous granules, but not deuterosomes, both of which have been suggested to play central roles in centriolar replication in ciliogenesis. These findings suggested that centriolar satellites and fibrous granules are identical novel nonmembranous organelles containing PCM-1, which may play some important role(s) in centriolar replication.  (+info)

Development of the human dispermic embryo. (7/575)

In a recent CD-ROM, we portrayed the microstructure of the pre-implantation human embryo (Sathananthan et al., 1999), which was a multimedia production with computer colour-enhanced electron micrographs of mainly monospermic embryos. This disk portrays light and electron micrographs of over 250 tripronuclear (3PN), dispermic, human embryos during pre-implantation development, viewed in thick and thin Araldite sections, as well as appearances of whole embryos flat embedded in Araldite blocks visualized with the light microscope. The 100 figures were computerized (IBM TIFF format), edited and labelled using Adobe Photoshop 5. Some of the figures were coloured on computer. The early development of 3PN embryos overtly resembles that of normal embryos but there are important differences in their microstructure which are portrayed in this presentation. This is a multicentric study involving researchers from four IVF centres.  (+info)

Concerning the localization of steroids in centrioles and basal bodies by immunofluorescence. (8/575)

Specific steroid antibodies, by the immunofluorescence technique, regularly reveal fluorescent centrioles and cilia-bearing basal bodies in target and nontarget cells. Although the precise identity of the immunoreactive steroid substance has not yet been established, it seems noteworthy that exogenous steroids can be vitally concentrated by centrioles, perhaps by exchange with steroids already present at this level. This unexpected localization suggests that steroids may affect cell growth and differentiation in some way different from the two-step receptor mechanism.  (+info)

Orofaciodigital syndrome (OFD) is a rare genetic disorder that affects the development of the face, mouth, and digits. It is also known as orofacial digital dysplasia or cranio-digital dysostosis. The condition is characterized by a range of symptoms including:

* Cleft lip and/or palate
* Abnormal facial features such as short or deformed ears, small jaw, or widely spaced eyes
* Missing or deformed teeth
* Short or absent fingers or toes
* Congenital heart defects or other physical abnormalities

The symptoms of OFD can vary in severity and may include one or more of these features. The exact cause of OFD is not known, but it is thought to be related to genetic mutations that occur during fetal development. There is no cure for OFD, but treatment options may include surgery, dental care, and speech therapy to help manage the symptoms.

The term "orofaciodigital" refers to the oral (face and mouth) and digital (fingers and toes) aspects of the syndrome. The condition is usually diagnosed during infancy or childhood, and the prognosis can vary depending on the severity of the symptoms. With appropriate medical care and support, many individuals with OFD can lead active and fulfilling lives.

CentrioleCentriole
Atypical centrioles are centrioles that do not have microtubules, such as the Proximal Centriole-Like found in D. melanogaster ... After duplication, the two centriole pairs (the freshly assembled centriole is now a daughter centriole in each pair) will ... Before DNA replication, cells contain two centrioles, an older mother centriole, and a younger daughter centriole. During cell ... The two centrioles in the centrosome are tied to one another. The mother centriole has radiating appendages at the distal end ...
https://en.wikipedia.org/wiki/Centriole
Proximal Centriole-LikeProximal Centriole-Like
The proximal centriole-like or PCL is an atypical type of centriole found in the sperm cells of insects. The PCL name is due to ... The PCL is an atypical type of centriole because it does not have microtubules, a defining feature of centrioles. However, the ... Another type of atypical type of centriole was discovered in human and bovine sperm. This is the distal centriole of the ... This spermatozoon distal centriole is composed of splayed microtubules surrounding previously undescribed rods of centriole ...
https://en.wikipedia.org/wiki/Proximal_Centriole-Like
MitosisMitosis
The cells of higher plants (such as the flowering plants) lack centrioles; instead, microtubules form a spindle on the surface ... Close to the nucleus of animal cells are structures called centrosomes, consisting of a pair of centrioles surrounded by a ... Basto R, Lau J, Vinogradova T, Gardiol A, Woods CG, Khodjakov A, Raff JW (June 2006). "Flies without centrioles". Cell. 125 (7 ...
https://en.wikipedia.org/wiki/Mitosis
Renata BastoRenata Basto
During her postdoc in the lab of Jordan Raff, Renata Basto investigated the role of centrioles in flies during development. Her ... "Plk4 Regulates Centriole Asymmetry and Spindle Orientation in Neural Stem Cells". Developmental Cell. 50 (1): 11-24.e10. doi: ... "Flies without Centrioles". Cell. 125 (7): 1375-1386. doi:10.1016/j.cell.2006.05.025. ISSN 0092-8674. PMID 16814722. S2CID ...
https://en.wikipedia.org/wiki/Renata_Basto
Sperm motilitySperm motility
The axoneme is attached at its base to a centriole known as the distal centriole and acts as a basal body. In most animals, ... In contrast, in mammals, the distal centriole evolved an atypical structure, known as the atypical distal centriole. The ... Avidor-Reiss, Tomer; Carr, Alexa; Fishman, Emily Lillian (December 2020). "The sperm centrioles". Molecular and Cellular ... this distal centriole act as a shock absorber preventing the microtubules filaments from moving at the axoneme base. ...
https://en.wikipedia.org/wiki/Sperm_motility
CentrosomeCentrosome
The mother centriole just aids in the accumulation of materials required for the assembly of the daughter centriole. Centrioles ... The mother centriole, the older of the two in the centriole pair, also has a central role in making cilia and flagella. The ... When the nematode C. elegans egg is fertilized, the sperm delivers a pair of centrioles. These centrioles will form the ... Many cells can completely undergo interphase without centrioles. Unlike centrioles, centrosomes are required for survival of ...
https://en.wikipedia.org/wiki/Centrosome
Centrosome cycleCentrosome cycle
... the daughter centriole which takes on characteristics of a mother centriole. Once they reach full length, the new centriole and ... However, the two centrioles are of different ages. This is because one centriole originates from the mother cell while the ... Centrioles are generated in new daughter cells through duplication of pre-existing centrioles in the mother cells. Each ... A diplosome is a rigid complex formed by an orthogonal mother and newly formed centriole (now a daughter centriole) that aids ...
https://en.wikipedia.org/wiki/Centrosome_cycle
SpermSperm
The neck or connecting piece contains one typical centriole and one atypical centriole such as the proximal centriole-like. The ... The fruit fly Drosophila melanogaster has a single centriole and an atypical centriole named the proximal centriole-like. The ... Sperm of many animals has two typical centrioles, known as the proximal centriole and distal centriole. Some animals (including ... humans and bovines) have a single typical centriole, the proximal centriole, as well as a second centriole with atypical ...
https://en.wikipedia.org/wiki/Sperm
InfertilityInfertility
The sperm must provide the zygote with DNA, centrioles, and activation factor for the embryo to develop. A defect in any of ... "Atypical centrioles during sexual reproduction". Frontiers in Cell and Developmental Biology. 3: 21. doi:10.3389/fcell. ...
https://en.wikipedia.org/wiki/Infertility
Male infertilityMale infertility
Age group 12-49 (Paternal age effect) Aneuploidy, an abnormal number of chromosomes Centriole Neoplasm, e.g. seminoma ... Avidor-Reiss, Tomer; Khire, Atul; Fishman, Emily L.; Jo, Kyoung H. (1 April 2015). "Atypical centrioles during sexual ...
https://en.wikipedia.org/wiki/Male_infertility
Cdc14Cdc14
Marshall, WF (2009). "Centriole evolution". Curr Opin Cell Biol. 21 (1): 14-19. doi:10.1016/j.ceb.2009.01.008. PMC 2835302. ... Wu, J; Cho, HP; Rhee, DB; Johnson, DK; Dunlap, J; Liu, Y; Wang, Y (2008). "Cdc14B depletion leads to centriole amplification, ... Whether flagella-anchoring basal bodies or centrioles involved in mitosis appeared first during evolution has been debated, but ... and its overexpression prevents unscheduled centriole duplication". J Cell Biol. 181 (3): 475-483. doi:10.1083/jcb.200710127. ...
https://en.wikipedia.org/wiki/Cdc14
Mónica Bettencourt-DiasMónica Bettencourt-Dias
In 2010, she received a grant from the European Research Council to investigate abnormalities in centrioles and how the ... Bettencourt-Dias, Mónica; Carvalho-Santos, Zita (2008). "Double life of centrioles: CP110 in the spotlight". Trends in Cell ... Bettencourt-Dias, Mónica; Glover, David M (September 2009). "SnapShot: Centriole Biogenesis". Cell. 136 (1): 188.e1-188.e2. doi ... Centered on centrioles". Journal of Cell Biology. New York City, New York: Rockefeller University Press. 190 (5): 710-711. doi: ...
https://en.wikipedia.org/wiki/Mónica_Bettencourt-Dias
ProcentrioleProcentriole
A procentriole (/proʊˈsɛntri.oʊl/ proh-SEN-tree-ohl) is a centriole or basal body in a stage of early development. That is, it ... Instead of forming in the vicinity of pre-exisintg centrioles, this "de novo" pathway is activated during ciliogenesis, in ... Procentrioles assemble perpendicular to existing centrioles. A cylindrical structure with a diameter around 130 nm forms at the ... This discovery was made through observation after removing the pre-existing centrioles using laser microbeam. However, studies ...
https://en.wikipedia.org/wiki/Procentriole
SDCCAG8SDCCAG8
This protein localizes to the centrioles. Mutations in SDCCAG8 have been found to cause nephronophthisis-related ciliopathies. ...
https://en.wikipedia.org/wiki/SDCCAG8
CarpediemonasCarpediemonas
Also, three centrioles are present in Carpediemonas. Carpediemonas is classified as an excavate because it has the ...
https://en.wikipedia.org/wiki/Carpediemonas
FlagellumFlagellum
Basal bodies are structurally identical to centrioles. The flagellum is encased within the cell's plasma membrane, so that the ...
https://en.wikipedia.org/wiki/Flagellum
CentrinCentrin
Centriole Centrosome "RCSB Protein Data Bank - Structure Summary for 3KF9 - Crystal structure of the SdCen/skMLCK complex". ... Centrins are required for duplication of centrioles. They may also play a role in severing of microtubules by causing calcium- ... Centrins are present in the centrioles and pericentriolar lattice. Human centrin genes are CETN1, CETN2 and CETN3. Centrin was ... Salisbury JL, Suino KM, Busby R, Springett M (2002). "Centrin-2 is required for centriole duplication in mammalian cells". Curr ...
https://en.wikipedia.org/wiki/Centrin
EukaryoteEukaryote
Centrioles are often present even in cells and groups that do not have flagella, but conifers and flowering plants have neither ... Centrioles produce the spindle during nuclear division. The significance of cytoskeletal structures is underlined in the ... They are supported by a bundle of microtubules arising from a centriole, characteristically arranged as nine doublets ... Conifers (Pinophyta) and flowering plants (Angiospermae) lack the flagellae and centrioles that are present in animal cells. ...
https://en.wikipedia.org/wiki/Eukaryote
Basal bodyBasal body
Thus, the basal body in such a cell is derived from the centriole. The basal body differs from the mother centriole in at least ... a modified centriole. The basal body serves as a nucleation site for the growth of the axoneme microtubules. Centrioles, from ... Plants lack centrioles and only lower plants (such as mosses and ferns) with motile sperm have flagella and basal bodies. ... Before the cell enters G1 phase, i.e. before the formation of the cilium, the mother centriole serves as a component of the ...
https://en.wikipedia.org/wiki/Basal_body
DeuterosomeDeuterosome
It was found that both centriole duplication and de novo generation of centrioles occurs in such cells. The generation of new ... Each cilium has a basal body formed from a centriole to which it is anchored and from which it starts to grow after each cell ... Centrioles typically replicate once during cell division, thus allowing for only one cilium for a daughter cell. Multiciliated ... Deborah A. Klos Dehring (2013). Deuterosome-Mediated Centriole Biogenesis. Developmental Cell 27, 103-112 Eric R. Brooks (2014 ...
https://en.wikipedia.org/wiki/Deuterosome
CEP97CEP97
Bettencourt-Dias M, Carvalho-Santos Z (2008). "Double life of centrioles: CP110 in the spotlight". Trends Cell Biol. 18 (1): 8- ... 2009). "Cep76, a centrosomal protein that specifically restrains centriole reduplication". Dev. Cell. 16 (5): 649-660. doi: ...
https://en.wikipedia.org/wiki/CEP97
CEP350CEP350
Furthermore, it increases the stability of growing centrioles. It is also implicated in the regulation of a class of nuclear ... "Role of CAP350 in centriolar tubule stability and centriole assembly". PLOS ONE. 3 (12): e3855. Bibcode:2008PLoSO...3.3855L. ...
https://en.wikipedia.org/wiki/CEP350
ApicomplexaApicomplexa
Centrioles, chloroplasts, ejectile organelles, and inclusions are absent. The cell is surrounded by a pellicle of three ...
https://en.wikipedia.org/wiki/Apicomplexa
CCP110CCP110
2006). "Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication". J. Cell Biol. 171 ... Pearson CG, Culver BP, Winey M (2007). "Centrioles want to move out and make cilia". Dev. Cell. 13 (3): 319-21. doi:10.1016/j. ...
https://en.wikipedia.org/wiki/CCP110
IMOD (software)IMOD (software)
Pelletier, Laurence; O'Tool, Eileen; Schwager, Anne; Hyman, Anthony A.; Müller-Reichert, Thomas (2006). "Centriole assembly in ...
https://en.wikipedia.org/wiki/IMOD_(software)
Pierre GönczyPierre Gönczy
His research focuses on centriole biology and asymmetric cell division. He is currently professor at École Polytechnique ... focused mainly on the questions of centriole assembly and function, as well as asymmetric cell division. His laboratory employs ... "Structural Basis of the 9-Fold Symmetry of Centrioles". Cell. 144 (3): 364-375. doi:10.1016/j.cell.2011.01.008. PMC 3089914. ... "Structural Basis of the 9-Fold Symmetry of Centrioles". Cell. 144 (3): 364-375. doi:10.1016/j.cell.2011.01.008. PMC 3089914. ...
https://en.wikipedia.org/wiki/Pierre_Gönczy
Spindle pole bodySpindle pole body
Unlike the centrosome the SPB does not contain centrioles. The SPB organises the microtubule cytoskeleton which plays many ...
https://en.wikipedia.org/wiki/Spindle_pole_body
TektinTektin
They are also present in centrioles and basal bodies. They are polymeric in nature, and form filaments. They include TEKT1, ...
https://en.wikipedia.org/wiki/Tektin
Microtubule organizing centerMicrotubule organizing center
Centrioles can act as markers for MTOCs in the cell. If they are freely distributed in the cytoplasm, centrioles can gather ... Centrioles do not exist in the MTOCs of yeast and fungi. In these organisms, the nuclear envelope does not break down during ... Plant cells lack centrioles or spindle pole bodies except in their flagellate male gametes, and they are entirely absent in the ... The MTOC is made up of a pair of centrioles at its center, and is surrounded by pericentriolar material (PCM) that is important ...
https://en.wikipedia.org/wiki/Microtubule_organizing_center
MyxozoaMyxozoa
Centrioles do not participate in the nuclear division of myxozoans. Cell division by binary fission is rare, and cells divide ...
https://en.wikipedia.org/wiki/Myxozoa
Plus itPlus it
... leading to a chiral centriole ensemble. Furthermore, we establish that the centriole is surrounded by a region from which ... Molecular architecture of the C. elegans centriole. Alexander Woglar, Marie Pierron, View ORCID ProfileFabian Zacharias ... However, localizing these components with high precision has been hampered by the minute size of the worm centriole, thus ... We uncovered that the procentriole assembles from a location on the centriole margin characterized by SPD-2 and ZYG-1 ...
https://www.biorxiv.org/content/10.1101/2022.05.09.491129v1
Taking Centrioles to the Elimination Round - PubMedTaking Centrioles to the Elimination Round - PubMed
... have begun to shed light on the mechanism of centriole elimination during female oogenesis, highlighting a protective role for ... Coping with centriole loss: pericentriolar material maintenance after centriole degeneration. Abreu CMC, Dantas TJ. Abreu CMC, ... Figure 1. Mechanism of centriole elimination in centrosomal and acentrosomal meiosis In starfish, centriole elimination (CE) ... Taking Centrioles to the Elimination Round Todd A Schoborg 1 , Nasser M Rusan 2 ...
https://www.ncbi.nlm.nih.gov/pubmed/27404354
Centriole Facts for KidsCentriole Facts for Kids
Centrioles are not found in vascular plants and in most fungi.. Most centrioles are nine sets of microtubule triplets, arranged ... The centriole is a cytoplasmic structure in most eukaryote cells. It is involved in cell division and in the formation of cilia ... A pair of centrioles, arranged perpendicularly and surrounded by a mass of dense material makes up the centrosome. ...
https://kids.kiddle.co/Centriole
Ofd1, a human disease gene, regulates the length and distal structure of centrioles - PubMedOfd1, a human disease gene, regulates the length and distal structure of centrioles - PubMed
... is a component of the distal centriole that controls centriole length. In the absence of Ofd1, distal regions of … ... Centrosomes and their component centrioles represent the principal microtubule organizing centers of animal cells. Here, we ... Graph shows centriole length data, collected from 9 WT and 23 Ofd1Gt centrioles. Each measured centriole was from a distinct ... is a component of the distal centriole that controls centriole length. In the absence of Ofd1, distal regions of centrioles, ...
https://pubmed.ncbi.nlm.nih.gov/20230748
INTERCELLULAR MIGRATION OF CENTRIOLES IN THE GERMARIUM OF DROSOPHILA MELANOGASTER | Journal of Cell Biology | Rockefeller...INTERCELLULAR MIGRATION OF CENTRIOLES IN THE GERMARIUM OF DROSOPHILA MELANOGASTER | Journal of Cell Biology | Rockefeller...
A cluster of centrioles has been found in the early Drosophila oocyte. Since the oocyte is connected to 15 nurse cells by a ... the possibility that the cluster of centrioles arose in the germarium from an intercellular migration of centrioles from the ... INTERCELLULAR MIGRATION OF CENTRIOLES IN THE GERMARIUM OF DROSOPHILA MELANOGASTER : An Electron Microscopic Study Anthony P. ... A cluster of centrioles has been found in the early Drosophila oocyte. Since the oocyte is connected to 15 nurse cells by a ...
https://rupress.org/jcb/article/45/2/306/1697/INTERCELLULAR-MIGRATION-OF-CENTRIOLES-IN-THE
Under supervision of Dr. Sherein Abdelgayed, Poster of Centrioles, Faculty of Physical Therapy, MUC, Egypt, 2022, | Sherein...Under supervision of Dr. Sherein Abdelgayed, Poster of Centrioles, Faculty of Physical Therapy, MUC, Egypt, 2022, | Sherein...
Sherein Abdelgayed, Poster of Centrioles, Faculty of Physical Therapy, MUC, Egypt, 2022,. *View ...
https://scholar.cu.edu.eg/?q=sherein-saeid-abdelgayed/presentations/under-supervision-dr-sherein-abdelgayed-poster-centrioles-fac
Centrioles | Biology Discussion
In this article we will discuss about the Structure and Functions of Centrioles. Structure of Centrioles: Centrioles are minute ... Centrioles: Structure and Functions (With Diagram). Article Shared by ...
https://www.biologydiscussion.com/tag/centrioles
Centriole Screen
PLEASE ENABLE JAVASCRIPT TO USE Centriole Screen !! ...
https://centriolescreen.vital-it.ch/
what do centrioles do » High Education Learningwhat do centrioles do » High Education Learning
what do centrioles do What are Centrioles, and Are They Present in Plant Cells?. November 10, 2022. September 17, 2021. by mike ... Centrioles are a kind of cell organelle present near the nucleoplasm. They exist chiefly in animal cells and … ...
https://higheducationlearning.com/tag/what-do-centrioles-do/
Investigating the maturation and duplication of mammalian centrioles. - Immunology
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https://www.immunology.ox.ac.uk/publications/21195?fc06013c-fea4-11ed-bff8-061b866677b4
Molecular Machines and Tissue Architecture | NHLBI, NIHMolecular Machines and Tissue Architecture | NHLBI, NIH
Bridging centrioles and PCM in proper space and time. Varadarajan R, Rusan NM. Essays in Biochemistry, 7;62(6):793-801 ... At the center of this connection lies the centriole with one end anchored firmly at the nuclear envelope and the other end ... Asterless is required for centriole length control and sperm development.. Authors: Galletta BJ, Jacobs KC, Fagerstrom CJ, ... Our lab is interested in the proper formation of basal bodies (centriole) that ensures the nucleation and anchoring of cilia. ...
https://www.nhlbi.nih.gov/node/91347
Molecular Machines and Tissue Architecture | NHLBI, NIHMolecular Machines and Tissue Architecture | NHLBI, NIH
Bridging centrioles and PCM in proper space and time. Varadarajan R, Rusan NM. Essays in Biochemistry, 7;62(6):793-801 ... At the center of this connection lies the centriole with one end anchored firmly at the nuclear envelope and the other end ... Asterless is required for centriole length control and sperm development.. Authors: Galletta BJ, Jacobs KC, Fagerstrom CJ, ... Our lab is interested in the proper formation of basal bodies (centriole) that ensures the nucleation and anchoring of cilia. ...
https://www.nhlbi.nih.gov/science/molecular-machines-and-tissue-architecture
SSANA ASSANA A
cytoplasmic centriole signal. English Text: cytoplasmic centriole signal. Target: Both males and females 12 YEARS - 150 YEARS. ... SSCYCEP - cytoplasmic centriole positive. Variable Name: SSCYCEP. SAS Label: cytoplasmic centriole positive. English Text: ... cytoplasmic centriole positive. Target: Both males and females 12 YEARS - 150 YEARS. Code or Value. Value Description. Count. ... Centriole Distinct dots (2-4/cell) in cytoplasm and at the poles of mitotic spindle. ...
https://wwwn.cdc.gov/Nchs/Nhanes/1999-2000/SSANA_A.htm
Superresolution characterization of core centriole architecture. | J Cell Biol;220(4)2021 04 05. | MEDLINESuperresolution characterization of core centriole architecture. | J Cell Biol;220(4)2021 04 05. | MEDLINE
During centriole biogenesis, Ana3 and Rcd4 are sequentially loaded on the newly formed centriole and are required for centriole ... Superresolution characterization of core centriole architecture. Superresolution characterization of core centriole ... It comprises of two centrioles and the surrounding pericentriolar material. Protein organization at the outer layer of the ... Together, our results provide a spatiotemporal map of the centriole core and implications of how the structure might be built. ...
https://pesquisa.bvsalud.org/bolivia/resource/es/mdl-33533934
Appendages !NEW! The distal appendages (DAPs) of centrioles | Group | The Intractable Prob
... of centrioles have been proposed to anchor cilia to the plasma membrane, but their molecular composition, assembly, and exact ...
https://www.theintractableproblems.com/group/mysite-200-group/discussion/5316aad1-1b40-41d8-b5b2-7c15e94c87e8
Control of Centriole Length by CPAP and CP110 :: MPG.PuReControl of Centriole Length by CPAP and CP110 :: MPG.PuRe
Control of Centriole Length by CPAP and CP110 ... 2009). Control of Centriole Length by CPAP and CP110. Current ...
https://pure.mpg.de/pubman/faces/ViewItemOverviewPage.jsp?itemId=item_1579223
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe...Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe...
CCHCR1-astrin interaction promotes centriole duplication through recruitment of CEP72 *Zhenguang Ying ...
https://www.nature.com/articles/s41588-021-01006-7?error=cookies_not_supported&code=3e9ca74c-e8bd-4121-80a0-bf1f29b9a9be
Drosophila Cep135/Bld10 maintains proper centriole structure but is dispensable for cartwheel formation. - Oxford Neuroscience
... an early intermediate in centriole assembly. Surprisingly, Cep135/Bld10 is not essential for centriole duplication in ... Using electron tomography and super-resolution microscopy we show that centrioles can form a cartwheel in the absence of Cep135 ... Thus, in flies, Cep135/Bld10 is not essential for cartwheel assembly or for establishing the ninefold symmetry of centrioles; ... but centriole width is increased and the cartwheel appears to disassemble over time. Using 3D structured illumination ...
https://www.neuroscience.ox.ac.uk/publications/352443?63c778e4-05e1-11ee-a69e-061ab7f93640
Centriole distal-end proteins CP110 and Cep97 influence cartwheel growth at the proximal-end of centrioles - Ludwig Cancer...
Here, we show that CP110 and Cep97 form a complex close to the distal-end of the centriole MTs whose levels oscillate as the ... The CP110/Cep97 oscillation does not appear to time the period of centriole MT growth, but rather the oscillation is entrained ... These findings reveal an unexpected crosstalk between factors normally concentrated at opposite ends of the growing centrioles ... The centriole cartwheel and MTs are thought to grow from opposite ends of these organelles, so it is unclear how they ...
https://www.ludwig.ox.ac.uk/research/publications/1185695
The centriole is a multifunctional structure that organizes centrosomes and cilia - nhibition of Hepatitis C Virus Replication
The centriole is a multifunctional structure that organizes centrosomes and cilia. The centriole is a multifunctional structure ... Little girl centriole MTs elongate during S and G2 stages from the cell routine. Little girl and Mom centrioles stay. ... B) Initiation of centriole formation. The mother centriole is demonstrated in a cross section. During G1, Plk4, an initiator of ... Both centrioles are constructed of nine MT triplets arranged within a ninefold radial symmetry. An adult centriole is normally ...
http://www.pkc-inhibitor.com/2019/06/30/the-centriole-is-a-multifunctional-structure-that-organizes-centrosomes-and-cilia/
Eukaryotic CellsEukaryotic Cells
The centrioles and pericentriolar material inside play a role in cell division and building microtubules ...
https://www.visiblebody.com/learn/biology/cells/eukaryotic-cells
Centrosome - Simple English Wikipedia, the free encyclopediaCentrosome - Simple English Wikipedia, the free encyclopedia
A centrosome is composed of two centrioles at right angles to each another. They are surrounded by a shapeless mass of protein ... Each daughter cell inherits one centrosome, containing two centrioles. The centrosome replicates during the interphase of the ...
https://simple.wikipedia.org/wiki/Centrosome
Biology Quiz : Mitosis - Worksheet / Test PaperBiology Quiz : Mitosis - Worksheet / Test Paper
centriole. mitotic spindle Answer: Answer: centriole. Prophase is the first phase of mitosis. It begins with the division of ... It begins with the division of centriole. Soon after the division, centrioles start moving towards the opposite poles. ...
https://www.syvum.com/cgi/online/serve.cgi/squizzes/biology/mitosis.html?question_hide
Publications - Genetics of Organelle Biogenesis Section - NIDDKPublications - Genetics of Organelle Biogenesis Section - NIDDK
Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly ... Centrioles: some self-assembly required.. Song MH, Miliaras NB, Peel N, OConnell KF.. Curr Opin Cell Biol (2008 Dec) 20:688-93 ... Control of mitotic and meiotic centriole duplication by the Plk4-related kinase ZYG-1.. Peters N, Perez DE, Song MH, Liu Y, ... Revisiting Centrioles in Nematodes-Historic Findings and Current Topics.. Schwarz A, Sankaralingam P, OConnell KF, Müller- ...
https://www.niddk.nih.gov/research-funding/at-niddk/labs-branches/laboratory-biochemistry-genetics/genetics-organelle-biogenesis-section/publications
Structure and function of distal and subdistal appendages of the mother centriole | Journal of Cell Science | The Company of...Structure and function of distal and subdistal appendages of the mother centriole | Journal of Cell Science | The Company of...
... the centriole possessing both types of appendage is older and referred to as the mother centriole, whereas the other centriole ... Centrosomes are composed of centrioles surrounded by pericentriolar material. The two centrioles in G1 phase are distinguished ... Structure and function of distal and subdistal appendages of the mother centriole In collection: Cell Cycle , Cilia and ... Structure and function of distal and subdistal appendages of the mother centriole. J Cell Sci 1 February 2023; 136 (3): ...
https://cob.silverchair.com/jcs/article-abstract/136/3/jcs260560/286880/Structure-and-function-of-distal-and-subdistal
Delivery services: Failure of centrosome migration causes a loss of motile cilia intalpid3mutants : TALPID3 Controls Centriole...
Failure of centrosome migration causes a loss of motile cilia intalpid3mutants : TALPID3 Controls Centriole Migration: TALPID3 ...
https://katalog.ub.tu-freiberg.de/Record/ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9kdmR5LjIzOTgw/DeliveryService
KEGG T00076: SPCC1682.04
Centriole proteins. SPCC1682.04 (cdc31). BRITE hierarchy. BRITE hierarchy. SSDB. Ortholog. Paralog. Gene cluster. GFIT. ...
https://www.genome.jp/dbget-bin/www_bget?spo:SPCC1682.04
Quiz: Cell Organelles and Their FunctionsQuiz: Cell Organelles and Their Functions
centrioles. ribosomes. Score = Correct answers:. This work is licensed under a Creative Commons Attribution-NonCommercial- ...
https://biologycorner.com/quiz/qz_cell.html
Centrosomes - LC Linked Data Service: Authorities and Vocabularies | Library of Congress
Centrioles. *. Exact Matching Concepts from Other Schemes. *. centrosomes *. Closely Matching Concepts from Other Schemes. *. ...
https://id.loc.gov/authorities/subjects/sh85021958.html
Fungi
Spindle pole bodies, not centrioles, usually are associated with the nuclear envelope during cell division. The characteristic ... Only chytrids among fungi have centrioles and lack spindle pole bodies. Copyright © Beth Richardson 1996. ... and centrioles are associated with nuclear division. The life cycles of almost all flagellated fungi are poorly studied. The ...
http://www.tolweb.org/Fungi/2377
CentrosomesDuplicationAppendagesElongationDamage and centrioleCentrosome is composedCiliaProteinsDaughter centriolesMitotic spindleMitochondriaDistalMicrotubuleCentrosomalPericentriolarCartwheelPolo-like kinaseBiogenesisPerpendicularlyBasalElegansNinefoldElongateRibosomesMammalianDrosophilaCP110KinaseStabilizeReplicationInitiationOrganelleSymmetryElectronNucleusFunctionsStructureCellsMiceOppositeCylinderAssemblyMotherLevels
Centrosomes4
  • Centrosomes and their component centrioles represent the principal microtubule organizing centers of animal cells. (nih.gov)
  • Centrioles make up the core of centrosomes which function as microtubule-organizing centers of the cell. (nih.gov)
  • The centriole is a multifunctional structure that organizes centrosomes and cilia and is important for cell signaling, cell cycle progression, polarity, and motility. (pkc-inhibitor.com)
  • 14. Cdk1 Phosphorylates Drosophila Sas-4 to Recruit Polo to Daughter Centrioles and Convert Them to Centrosomes. (nih.gov)
Duplication15
  • CENPJ is a central component of centrioles required for centriole duplication. (nih.gov)
  • Investigating the maturation and duplication of mammalian centrioles. (ox.ac.uk)
  • Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication. (nih.gov)
  • The E2F-DP1 Transcription Factor Complex Regulates Centriole Duplication in Caenorhabditis elegans. (nih.gov)
  • Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. (nih.gov)
  • Control of mitotic and meiotic centriole duplication by the Plk4-related kinase ZYG-1. (nih.gov)
  • Surprisingly, Cep135/Bld10 is not essential for centriole duplication in Drosophila, suggesting either that Cep135/Bld10 is not essential for cartwheel formation, or that the cartwheel is not essential for centriole assembly in flies. (ox.ac.uk)
  • Centrosome framework and centriole duplication routine in vertebrates. (pkc-inhibitor.com)
  • C) Rabbit polyclonal to SLC7A5 Canonical centriole duplication cycle. (pkc-inhibitor.com)
  • 6. YLT-11, a novel PLK4 inhibitor, inhibits human breast cancer growth via inducing maladjusted centriole duplication and mitotic defect. (nih.gov)
  • 9. Plk2 regulated centriole duplication is dependent on its localization to the centrioles and a functional polo-box domain. (nih.gov)
  • 16. Playing polo in G1: a novel function of polo-like kinase-2 in centriole duplication. (nih.gov)
  • 19. Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication-Impact on Cancer. (nih.gov)
  • 2023. Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells. (nih.gov)
  • 2020. Requirement of the Cep57-Cep63 interaction for proper Cep152 recruitment and centriole duplication. (nih.gov)
Appendages2
  • Our results indicate that Ofd1 acts at the distal centriole to build distal appendages, recruit Ift88, and stabilize centriolar microtubules at a defined length. (nih.gov)
  • Younger centrioles absence appendages and also have less abundant PCM. (pkc-inhibitor.com)
Elongation3
  • Distinct disease-associated mutations cause different degrees of excessive or decreased centriole elongation, all of which are associated with diminished ciliogenesis. (nih.gov)
  • Cdk2 promotes centriole elongation and stops reduplication. (pkc-inhibitor.com)
  • 15. Ana1 helps recruit Polo to centrioles to promote mitotic PCM assembly and centriole elongation. (nih.gov)
Damage and centriole2
  • 13. Link between DNA damage and centriole disengagement/reduplication in untransformed human cells. (nih.gov)
  • Treatment of Cep290-deficient cells with CDK inhibitors rescued DNA damage and centriole number. (nih.gov)
Centrosome is composed2
  • 2015). The animal centrosome is composed by two centrioles surrounded by a protein-rich material, the pericentriolar matrix (PCM). (pkc-inhibitor.com)
  • A centrosome is composed of two centrioles at right angles to each another. (wikipedia.org)
Cilia1
  • 2015). When mature fully, centrioles type a framework termed the basal body CP-673451 manufacturer that's necessary to nucleate a cilium (Fig. 1 A). Cilia features consist of cell motility, motion of liquids, and specific sensory features like a response to light. (pkc-inhibitor.com)
Proteins2
  • During G1, Plk4, an initiator of centriole formation, is structured inside a ringlike pattern around the mother centriole along with centrosomal proteins Cep63, Cep152, and Cep192, which aid in Plk4 recruitment. (pkc-inhibitor.com)
  • These three proteins form the cartwheel towards the proximal wall from the mom centriole perpendicularly. (pkc-inhibitor.com)
Daughter centrioles1
  • Distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes. (nih.gov)
Mitotic spindle1
  • Cellular tubulin, mitotic spindle integrity and centriole number were determined by immunofluorescence for betatubulin and centrin and photographed using fluorescent and confocal laser scanning microscopy. (cdc.gov)
Mitochondria1
  • The phrase "lives of a cell" refers to the independent yet interrelated parts of a human cell-including mitochondria, centrioles, and basal bodies-that once led independent lives. (cdc.gov)
Distal4
  • Here, we show that the gene underlying orofaciodigital syndrome 1, Ofd1, is a component of the distal centriole that controls centriole length. (nih.gov)
  • In the absence of Ofd1, distal regions of centrioles, but not procentrioles, elongate abnormally. (nih.gov)
  • Ofd1 is also important for centriole distal appendage formation and centriolar recruitment of the intraflagellar transport protein Ift88. (nih.gov)
  • Here, we show that CP110 and Cep97 form a complex close to the distal-end of the centriole MTs whose levels oscillate as the new centriole MTs grow. (ox.ac.uk)
Microtubule2
  • Most centrioles are nine sets of microtubule triplets, arranged in a cylinder. (kiddle.co)
  • Centrioles perform two distinct cellular functions: (i) they form core components required to build the centrosome and (ii) they form the basal body that templates formation of the cilium, a microtubule-based specialized signaling organelle. (nih.gov)
Centrosomal3
  • In starfish, centriole elimination (CE) occurs during centrosomal meiosis via two mechanisms - polar body (PB) extrusion and PCM-loss + Centriole Destruction (CD). (nih.gov)
  • Using the degradation of cyclin B, a conserved cascade of centrosomal protein initiates little girl centriole development. (pkc-inhibitor.com)
  • 11. Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels. (nih.gov)
Pericentriolar2
  • 2016) have begun to shed light on the mechanism of centriole elimination during female oogenesis, highlighting a protective role for Polo kinase and the pericentriolar material. (nih.gov)
  • It comprises of two centrioles and the surrounding pericentriolar material. (bvsalud.org)
Cartwheel6
  • Drosophila Cep135/Bld10 maintains proper centriole structure but is dispensable for cartwheel formation. (ox.ac.uk)
  • Cep135/Bld10 is a conserved centriolar protein required for the formation of the central cartwheel, an early intermediate in centriole assembly. (ox.ac.uk)
  • Using electron tomography and super-resolution microscopy we show that centrioles can form a cartwheel in the absence of Cep135/Bld10, but centriole width is increased and the cartwheel appears to disassemble over time. (ox.ac.uk)
  • The centriole cartwheel and MTs are thought to grow from opposite ends of these organelles, so it is unclear how they coordinate their assembly. (ox.ac.uk)
  • Panel II shows a mix section through the proximal parts of the centrioles with or without cartwheel. (pkc-inhibitor.com)
  • Centriole CP-673451 manufacturer initiation begins in the G1/S transition by focusing Plk4 to the site of the future child centriole and by forming a ninefold-symmetrical cartwheel, a structure composed of a central hub and nine radially structured spokes and pinheads. (pkc-inhibitor.com)
Polo-like kinase2
  • Reversible centriole depletion with an inhibitor of Polo-like kinase 4. (nih.gov)
  • 2019. Phase separation of polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis. (nih.gov)
Biogenesis3
  • Overall, our work uncovers the molecular architecture of the C. elegans centriole in unprecedented detail and establishes a comprehensive framework for understanding mechanisms of organelle biogenesis and function. (biorxiv.org)
  • During centriole biogenesis, Ana3 and Rcd4 are sequentially loaded on the newly formed centriole and are required for centriole -to- centrosome conversion through recruiting the Cep135-Ana1-Asterless complex. (bvsalud.org)
  • 2020. A self-assembled cylindrical platform for Plk4-induced centriole biogenesis. (nih.gov)
Perpendicularly1
  • A pair of centrioles, arranged perpendicularly and surrounded by a mass of dense material makes up the centrosome . (kiddle.co)
Basal1
  • Structure of Centrioles: Centrioles are minute-sub-microscopic micro tubular sub cylinders with a configuration of nine triplet fibrils and ability to form their own duplicates, astral poles and basal bodies, without having DNA and a membranous covering. (biologydiscussion.com)
Elegans1
  • C. elegans was key in identifying evolutionary conserved components governing assembly of the centriole organelle. (biorxiv.org)
Ninefold2
  • Using 3D structured illumination microscopy we show that Cep135/Bld10 is localized to a region between inner (SAS-6, Ana2) and outer (Asl, DSpd-2 and D-PLP) centriolar components, and the localization of all these component is subtly perturbed in the absence of Cep135/Bld10, although the ninefold symmetry of the centriole is maintained. (ox.ac.uk)
  • Both centrioles are constructed of nine MT triplets arranged within a ninefold radial symmetry. (pkc-inhibitor.com)
Elongate1
  • Little girl centriole MTs elongate during S and G2 stages from the cell routine. (pkc-inhibitor.com)
Ribosomes1
  • Furthermore, we establish that the centriole is surrounded by a region from which ribosomes are excluded and to which SAS-7 localizes. (biorxiv.org)
Mammalian1
  • 12. Centriole age underlies asynchronous primary cilium growth in mammalian cells. (nih.gov)
Drosophila1
  • A cluster of centrioles has been found in the early Drosophila oocyte. (rupress.org)
CP1101
  • The CP110/Cep97 oscillation does not appear to time the period of centriole MT growth, but rather the oscillation is entrained by the core Cdk/Cyclin oscillator that drives the nuclear divisions in these embryos. (ox.ac.uk)
Kinase1
  • The ZYG-1 kinase, a mitotic and meiotic regulator of centriole replication. (nih.gov)
Stabilize1
  • rather, it appears to stabilize the connection between inner and outer centriole components. (ox.ac.uk)
Replication1
  • Compared with those from WT mice, primary kidney cells from Cep290-deficient mice exhibited supernumerary centrioles, decreased replication fork velocity, fork asymmetry, and increased levels of cyclin-dependent kinases (CDKs). (nih.gov)
Initiation1
Organelle1
Symmetry1
  • Importantly, we discovered that SAS-6 and SAS-4 exhibit a radial symmetry that is offset relative to microtubules, leading to a chiral centriole ensemble. (biorxiv.org)
Electron3
  • Here, we used Ultrastructure Expansion coupled with STimulated Emission Depletion microscopy (U-Ex-STED), as well as electron microscopy (EM) and tomography (ET), to decipher the molecular architecture of the worm centriole. (biorxiv.org)
  • Electron micrograph of a centriole from a mouse embryo. (kiddle.co)
  • Since the oocyte is connected to 15 nurse cells by a system of intercellular bridges or ring canals, the possibility that the cluster of centrioles arose in the germarium from an intercellular migration of centrioles from the nurse cells to the oocyte was analyzed in serial sections for the electron microscope. (rupress.org)
Nucleus1
  • Later, these centrioles become located between the oocyte nucleus and the follicle cell border and become aggregated into a cluster less than 1.5 µ in its largest dimension. (rupress.org)
Functions1
Structure2
  • The centriole is a cytoplasmic structure in most eukaryote cells . (kiddle.co)
  • Together, our results provide a spatiotemporal map of the centriole core and implications of how the structure might be built. (bvsalud.org)
Cells3
  • Initially, all of the 16 cells of the future egg chambers possess centrioles, which are located in a juxtanuclear position. (rupress.org)
  • By the time the 16 cell cluster of cells is surrounded by follicle cells (Stage 1), between 14 and 17 centrioles are found in the oocyte. (rupress.org)
  • What are Centrioles, and Are They Present in Plant Cells? (higheducationlearning.com)
Mice1
  • Remarkably, deleting p53 fully rescued the craniofacial phenotypes in CenpJ-deficient mice, emphasizing p53's role in facial dysmorphology due to centriole loss. (nih.gov)
Opposite2
  • These findings reveal an unexpected crosstalk between factors normally concentrated at opposite ends of the growing centrioles, which may help to coordinate centriole growth. (ox.ac.uk)
  • Soon after the division, centrioles start moving towards the opposite poles. (syvum.com)
Cylinder1
  • Each centriole is a short cylinder containing nine pairs of peripheral microtubules, arranged so as to form the wall of the cylinder. (nih.gov)
Assembly2
  • Centrioles: some self-assembly required. (nih.gov)
  • 12. Asterless is a scaffold for the onset of centriole assembly. (nih.gov)
Mother1
Levels1
  • The chromatin remodeling protein CHD-1 and the EFL-1/DPL-1 transcription factor cooperatively down regulate CDK-2 to control SAS-6 levels and centriole number. (nih.gov)