The mechanism, in central lymphoid organs (THYMUS; BONE MARROW), that prevents immature lymphocytes from reacting to SELF-ANTIGENS. This is accomplished by CLONAL ANERGY and CLONAL DELETION.
The normal lack of the ability to produce an immunological response to autologous (self) antigens. A breakdown of self tolerance leads to autoimmune diseases. The ability to recognize the difference between self and non-self is the prime function of the immune system.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Removal, via CELL DEATH, of immature lymphocytes that interact with antigens during maturation. For T-lymphocytes this occurs in the thymus and ensures that mature T-lymphocytes are self tolerant. B-lymphocytes may also undergo clonal deletion.
Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.
Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
A member of the tumor necrosis factor receptor superfamily. It has specificity for LYMPHOTOXIN ALPHA1, BETA2 HETEROTRIMER and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14. The receptor plays a role in regulating lymphoid ORGANOGENESIS and the differentiation of certain subsets of NATURAL KILLER T-CELLS. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Autoimmune diseases affecting multiple endocrine organs. Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (CANDIDIASIS, CHRONIC MUCOCUTANEOUS), while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis (THYROIDITIS, AUTOIMMUNE;), HYPOPARATHYROIDISM; and gonadal failure. In both types organ-specific ANTIBODIES against a variety of ENDOCRINE GLANDS have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A strain of non-obese diabetic mice developed in Japan that has been widely studied as a model for T-cell-dependent autoimmune insulin-dependent diabetes mellitus in which insulitis is a major histopathologic feature, and in which genetic susceptibility is strongly MHC-linked.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Antibodies produced by a single clone of cells.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.

Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape. (1/8)

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Complete diabetes protection despite delayed thymic tolerance in NOD8.3 TCR transgenic mice due to antigen-induced extrathymic deletion of T cells. (2/8)

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Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes. (3/8)

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Role of impaired central tolerance to alpha-myosin in inflammatory heart disease. (4/8)

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Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance. (5/8)

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Thymus-homing dendritic cells in central tolerance. (6/8)

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Characterization of human thymic exosomes. (7/8)

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CVID-associated TACI mutations affect autoreactive B cell selection and activation. (8/8)

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Unmodified histone proteins such as H3 and H4 are useful for studying epigenetic mechanisms such as histone methylation, histone acetylation, and histone phosphorylation, which occur as a result of the modification to histone...
The induction of hematopoietic mixed chimerism, defined as the coexistence of donor and recipient hematopoietic cells, could be an approach to induce robust central tolerance. This strategy capitalizes on the use of nonmyeloablative hematopoietic stem cell transplantation (HSCT) prior to injection of myogenic stem cells from the donor HST (Parker et al. 2008). In this study two irradiated GRMD dogs with established full or partial chimerism first achieved at 11-26 months, were injected with donor-specific muscle-derived cells. The recipient dogs were transiently immunosuppressed with cyclosporine for 40 days. Local dystro-phin expression, up to 6.5% of normal levels, was sustained for periods up to 24 months post injection. This strategy is promising, as novel developments in the area of nonmyeloablative HSCT are ongoing for other cell-based therapies for benign diseases. Induction of central tolerance by intrathymic injection of viral vectors has been tested in rodents, and offers alternatives ...
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 Lys-79 dimethylation (H3K79me2) and gene activation (PubMed:26439302).
The invention relates to the methods for producing hematopoietic chimerism and central tolerance by peripheral tolerance induction without myeloablative conditioning.
In this project we propose to determine the role of candidate G protein-coupled receptors (GPCRs) in enforcing deletion of developing auto-reactive T cells in t...
Most human cancers acquire tens to hundreds of somatic mutations (termed the tumor mutome) during their development (1). Each of these mutations has the potential to generate one or more novel T-cell antigens (termed neoepitopes) uniquely specific to each individual patients tumor. Because these neoepitopes are not present in the germline, and are not encountered until after the onset of oncogenesis, repertoires of high-avidity T cells capable of recognizing them may avoid central tolerance and escape deletion in the thymus. For these reasons, numerous investigators have proposed that the tumor mutome provides an attractive source of antigenic targets for developing patient-specific tumor vaccines (2-5).. Because it is already possible to rapidly and comprehensively identify tumor mutations using next-generation DNA- and RNA-sequencing technologies (1), the first technical hurdle for the development of this approach has been overcome. However, it may not be practical to target the full ...
This Podcast features an interview with Vassiliki Boussiotis, senior author of a Research Article published in the 26 June 2012 issue of Science Signaling. Boussiotis discusses her groups investigation of a molecular mechanism by which autoreactive T cells are suppressed in the periphery. Most autoreactive T cells are eliminated by mechanisms of central tolerance in the bone marrow or thymus before they enter the circulation. Autoreactive T cells that escape central tolerance are suppressed or eliminated by mechanisms of peripheral tolerance. Boussiotiss group has described a molecular chain of events downstream of the receptor programmed death-1 (PD-1) that inhibit proliferation of autoreactive T cells.. ...
The term immunogenic cell death (ICD) denotes an immunologically unique type of regulated cell death that enables, rather than suppresses, T cell-driven immune responses that are specific for antigens derived from the dying cells. The ability of ICD to elicit adaptive immunity heavily relies on the immunogenicity of dying cells, implying that such cells must encode and present antigens not covered by central tolerance (antigenicity), and deliver immunostimulatory molecules such as damage-associated molecular patterns and cytokines (adjuvanticity). Moreover, the host immune system must be equipped to detect the antigenicity and adjuvanticity of dying cells. As cancer (but not normal) cells express several antigens not covered by central tolerance, they can be driven into ICD by some therapeutic agents, including (but not limited to) chemotherapeutics of the anthracycline family, oxaliplatin and bortezomib, as well as radiation therapy. In this Trial Watch, we describe current trends in the ...
Neoantigens, which are derived from tumour-specific protein-coding mutations, are exempt from central tolerance, can generate robust immune responses and can function as bona fide antigens that facilitate tumour rejection.
Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to substances or tissue that have the capacity to elicit an immune response in given organism. It contrasts with conventional immune-mediated elimination of foreign antigens (see Immune response). Tolerance is classified into central tolerance or peripheral tolerance depending on where the state is originally induced-in the thymus and bone marrow (central) or in other tissues and lymph nodes (peripheral). The mechanisms by which these forms of tolerance are established are distinct, but the resulting effect is similar. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.). Deficits in central or peripheral tolerance also cause autoimmune ...
(14) X-Linked SCID IL-2Rγ mutation 6 mo M has thrush, RSV, Pseudomonas aeruginosa No T-cells, low Ig levels Normal B-cell count, did not react to IL-2Rγ Unresponsive to PHA, ConA, PWM, immunizations Complete non-random X- chromosome inactivation Tx: IVIg, ribavirin, TMP-STX, maternal marrow graft SCID: Thrush, persistent cough, intractable diarrhea X-linked is different because B-cell count is normal Mutation in IL-2Rγ (Xq11) is also part of IL-7 involved in T-cell development Successful bone marrow graft yields normal life with Ig-therapy
The postnatal thymus is an efficient microenvironment for T cell specification and differentiation. B cells are also present in the thymus, and have been recently implicated in the central tolerance. In Foxn1lacZmutant mice, which undergo premature thymic involution beginning 1 week after birth, T committed progenitors were progressively reduced, however, thymic B cells started to increase at 1 week and transiently formed a peak at 3-4 weeks. These increased B cells were developed from neonatal derived BM progenitors possessing a high B potential, were originally generated in the thymus. Most of them showed CD19loB220loCD24hiCD43+/−IgM−progenitor phenotype with increased expression of Ly51 but decrease of CD25 accumulating at pre-B-II stage. These B progenitors showed a delayed down-regulation of Lin28b, an impaired up-regulation of Let-7 with an increased expression of Arid3a. However the treatment of these progenitor B cells with Vitamin D3 might up-regulate Let-7 and down-regulate Arid3 ...
Autoimmunity arises from a failure of the immune system to establish or maintain self-tolerance. In the thymus, developing T cells are exposed to self-peptides derived from genetically encoded proteins, and self-reactive T cells are either deleted or develop a regulatory phenotype before venturing into the periphery. Post-translational modification (PTM) of self-peptides in the periphery may lead to the generation of neo-epitopes that are not displayed in the thymus. T cells specific for these modified peptides can bypass central tolerance mechanisms and escape into the periphery where they may ...
O timo é um órgão linfoide primário onde ocorre o estabelecimento da tolerância imunológica central pela eliminação de clones de linfócitos T auto reativos. Precursores de linfócitos T adentram o timo...
Ilan Y, Attavar P, Takahashi M, Davidson A, Horwitz M, Guida J, Chowdhury N Roy, Chowdhury J. Roy Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats. J Clin Invest 1996; 98: 2640-2647 ...
Lee JJ, Rauter I, Garibyan L, Ozcan E, Sannikova T, Dillon SR, Cruz AC, Siegel RM, Bram R, Jabara H, Geha RS. The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function. Blood. 2009 Sep 10; 114(11):2254-62. View abstract ...
Mice. C57BL/6 AireGW/+ mice (17) and C57BL/6 AireGW/+ TRP-1 TCR Tg RAG−/− mice (11) were housed and bred in sterile, specific pathogen-free mouse facilities at the University of North Carolina at Chapel Hill and UCSF. C57BL/6 Aire WT littermate controls were used in all experiments. RAG1−/− mice were purchased from the Jackson Laboratory.. Antibodies and flow cytometry. Anti-CD4 (clone RM4-5), anti-CD3 (clone 145-2c11), anti-Ki67 (clone SolA15), anti-KLRG1 (clone 2F1), anti- granzyme B (clone NGZB), anti-FOXP3 (clone FJK-16s), and anti-CD25 (clone PC61.5) antibodies were purchased from eBioscience. Anti-CD8a (clone 5H10) antibody was purchased from Invitrogen. Intracellular staining for cytokines and FOXP3 were performed as in ref. 11. All samples were run on a Dako CyAn flow cytometer (Beckman-Coulter) and analyzed using FlowJo (TreeStar Inc.).. Isolation of TILs. TILs were isolated as previously described (11). Tumors were dissected and minced before incubation with collagenase type ...
Promising data from trials investigating T/NK-cells modified to express CARs against tumour antigens have generated extensive interest from clinicians, researchers and pharmaceutical companies, leading to broaden the applications of CARs beyond cancer through other pathologies, as autoimmune diseases or allograft rejection [13,14]. Autoimmunity can be broadly separated in two processes: via self-reactive antibodies or autoantibodies (produced by plasma cells from the B lymphocyte lineage), and/or via self-reactive T-lymphocytes. This may occur during the processes of selection of those cells during their development (central tolerance), in which negative selection to self-antigens fails, or due to changes in target tissues (break of peripheral tolerance). Between these peripheral autoimmune mechanisms, there are the autorreactivitiy against the so-called sequestered antigens (self-antigens present in isolated areas of the organism that are not exposed in normal conditions), that become ...
T cell receptor recognition of peptide Ags presented by class I or class II MHC proteins is a cornerstone of cellular immunity. Recognition of foreign Ags forms the basis for defense against viruses and other pathogens, yet recognition of self Ags can lead to autoimmunity. Although the central tolerance mechanism of negative selection plays a protective role against autoimmunity, the high level of cross-reactivity present within the T cell repertoire can promote autoimmunity if T cells are activated by foreign Ags that share key structural or chemical features with self Ags. This concept of molecular mimicry has been implicated in a number of autoimmune pathologies, including type 1 diabetes, lupus, and multiple sclerosis (1-3).. Previously determined structures of TCRs in complex with self Ags associated with autoimmunity have shown deviations from the binding mode traditionally seen in TCR recognition of foreign Ags. The traditional binding mode, typified by the structure of the αβ A6 TCR ...
Medullary thymic epithelial cells (mTECs) serve an essential function in central tolerance by expressing peripheral-tissue antigens. These antigens may be transferred to and presented by dendritic cells (DCs). Therefore, it is unclear whether mTECs, in addition to being an antigen reservoir, also serve a mandatory function as antigen-presenting cells. Here we diminished major histocompatibility complex (MHC) class II on mTECs through transgenic expression of a designer microRNA specific for the MHC class II transactivator CIITA (called C2TA here). This resulted in an enlarged polyclonal CD4+ single-positive compartment and, among thymocytes specific for model antigens expressed in mTECs, enhanced selection of regulatory T cells (Treg cells) at the expense of deletion. Our data document an autonomous contribution of mTECs to both dominant and recessive mechanisms of CD4+ T cell tolerance and support an avidity model of Treg cell development versus deletion.
Dendritic cells (DCs) are known to regulate immune responses by inducing both central and peripheral tolerance. DCs play a vital role in negative selection of developing thymocytes by deleting T cells with high-affinity for self-peptide-major histocompatibility complexes. In the periphery, DCs mediate peripheral tolerance by promoting regulatory T-cell development, induction of T-cell unresponsiveness, and deletion of activated T cells. We studied whether allogeneic DCs, obtained from bone marrow cultured with either Flt3L (FLDCs) or granulocyte-macrophage colony-stimulating factor (GMDCs), could induce allospecific central and peripheral tolerance after IV injection; B cells were used as a control. The results showed that only FLDCs reached the thymus after injection and that these cells induced both central and peripheral tolerance to donor major histocompatibility complexes. For central tolerance, injection of FLDCs induced antigen-specific clonal deletion of both CD8 and CD4 single-positive
Advanced testicular germ cells, expressing novel cell surface area and intracellular proteins, show up following the establishment of central tolerance and so are auto-immunogenic so. myoid cells, additional expands its program to review testis morphogenesis. We will also discuss the potential use of this model to study the effects of drugs/environmental toxins on testis morphogenesis, tight junction formation and SCCmyoid cell interactions. [32], co-grafted allogeneic pancreatic islets with syngeneic or allogeneic SC-enriched fractions underneath the kidney capsule of INCB8761 supplier diabetic rats. In this study, 65% of the co-grafted animals remained normoglycemic for over 100 days, while none of the animals receiving islets alone became normoglycemic. However, a short course of immune suppression (cyclosporine for 3 days) was INCB8761 supplier required for the SCs to prolong survival of allogeneic islets. Korbutt [33], extended these results by modifying the SC isolation method and adding a ...
... is not perfect, so peripheral tolerance exists as a secondary mechanism to ensure that T and B cells are not ... Peripheral tolerance is distinct from central tolerance in that it occurs once developing immune cells exit primary lymphoid ... Central tolerance is essential to proper immune cell functioning because it helps ensure that mature B cells and T cells do not ... More specifically, central tolerance is necessary because T cell receptors (TCRs) and B cell receptors (BCRs) are made by cells ...
Tolerance is classified into central tolerance or peripheral tolerance depending on where the state is originally induced-in ... Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to ... This difference is important to keep in mind.[citation needed] Central tolerance refers to the tolerance established by ... Immune Tolerance Network International Conference on Immune Tolerance Immune+tolerance at the US National Library of Medicine ...
In immunology, peripheral tolerance is the second branch of immunological tolerance, after central tolerance. It takes place in ... Tregs are the central mediators of immune suppression and they play a key role in maintaining peripheral tolerance. The master ... Although the majority of self-reactive T cell clones are deleted in the thymus by the mechanisms of central tolerance, low ... Dependence of a particular antigen on either central or peripheral tolerance is determined by its abundance in the organism. B ...
In a process known as "Central Tolerance", T-cells are exposed to cortical epithelial cells that express a variety of different ... Xing Y, Hogquist KA (June 2012). "T-cell tolerance: central and peripheral". Cold Spring Harbor Perspectives in Biology. 4 (6 ... Tolerance to self-protein is crucial for overall wellbeing; when the body erroneously identifies self-proteins as "non-self", ...
Immune tolerance Central tolerance Peripheral tolerance regulatory T cells Immune response Immune tolerance in pregnancy ... Infectious tolerance is a term referring to a phenomenon where a tolerance-inducing state is transferred from one cell ... The goal is to achieve long-term tolerance of the transplant through short-term therapy. The term "infectious tolerance" was ... Because second-generation tolerance arises in the absence of any monoclonal antibodies to CD4 or CD8, it probably represents a ...
Two processes of central tolerance take place in thymic medulla, namely clonal deletion (recessive tolerance) and T Regulatory ... The most efficient subset in TRA presentation and both modes of central tolerance was found to be CD8α+ thymic-derived DCs ( ... Indispensability of DCs for the establishment of central tolerance was further verified by recent analysis, which revealed that ... Gallegos AM, Bevan MJ (October 2004). "Central tolerance to tissue-specific antigens mediated by direct and indirect antigen ...
Pelanda R, Torres RM (April 2012). "Central B-cell tolerance: where selection begins". Cold Spring Harbor Perspectives in ... This negative selection process leads to a state of central tolerance, in which the mature B cells do not bind self antigens ...
Tolerogenic DCs are essential in maintenance of central and peripheral tolerance through induction of T cell clonal deletion, T ... Tol-DCs promotes central and peripheral tolerance. These tolerogenic properties are executed by deletion of T cells, induction ... Moreover, Ag-specific tolerance in humans can be induced in vivo via vaccination with Ag-pulsed ex vivo generated tolerogenic ... Therefore, CD83high IL-10DCs could be promising and great candidates for tolerance-inducing vaccination studies in vivo. In ...
In aging of the immune system is also a decrease in central tolerance and an increase in the number of autoreactive T cells. B ... APECED causes loss of central immune tolerance. Omenn syndrome manifests as GVHD (graft versus host disease)-like autoimmune ...
Nemazee D (October 2006). "Receptor editing in lymphocyte development and central tolerance". Nature Reviews. Immunology. 6 (10 ...
Metzger, T.C. (2011). "Control of Central and Peripheral Tolerance by Aire". Immunological Reviews. 241 (1): 89-103. doi: ...
Hayreh, SS; Kolder, HE; Weingeist, TA (1980). "Central retinal artery occlusion and retinal tolerance time". Ophthalmology. 87 ... Hayreh, SS (1983). "Classification of central retinal vein occlusion". Ophthalmology. 90 (5): 458-74. doi:10.1016/s0161-6420(83 ... Neetens of the existence of the central artery of the optic nerve; Hayreh found instead that the artery did not exist. In 1961 ...
", "Identity" and "Liberty". In 2011 the festival's central theme will be "Tolerance". Film festivals in North and Central ...
David Weberman (8 July 2016). Space and Pluralism: Can Contemporary Cities Be Places of Tolerance?. Central European University ...
... making it a type of negative selection or central tolerance. Central tolerance prevents B and T lymphocytes from reacting to ... Thus, the host develops a tolerance for this antigen, or a self tolerance. B and T lymphocytes are tested for their affinity ... It is one method of immune tolerance. Frank Macfarlane Burnet proposed autoreactive cells would be terminated before maturation ...
Both cTEC and mTEC participate in imposing central and peripheral tolerance. cTECs play a key role in the positive selection ... Type 1 diabetes is a result of the absence of self-tolerance, which is characterized by a decreased expression of Insulin 1 and ... TECs, as a component of the thymus, play a key role in thymocyte development and self-tolerance, so their dysfunction causes ... Medulla is also important for implementation of self tolerance, which is mediated by CD4+CD25+Foxp3 nTreg cells. Foxp3 Treg ...
"Chilling tolerance of central European maize lines and their factorial crosses". Annals of Botany. 100 (6): 1315-1321. doi: ... Farooq, M., Aziz, T., Wahid, A., Lee, D. J., & Siddique, K. H. (2009). "Chilling tolerance in maize: agronomic and ... Another approach is to breed for increased chilling tolerance. This would make earlier sowing possible and elongate the ... which were more suitable to the colder climate in northern and central Europe than the varieties from South America. Rheintaler ...
Beijing has little tolerance for any talk of central-bank independence; the monetary authority, just like any other part of the ... Its central bank status was legally confirmed on March 18, 1995 by the 3rd Plenum of the 8th National People's Congress, and ... However, since the central bank began to increase rates by 0.25 percentage points on October 19, 2010, this is no longer the ... The People's Bank of China (officially PBC or informally PBOC; Chinese: 中国人民银行) is the central bank of the People's Republic of ...
"Human Chorionic Gonadotropin as a Central Regulator of Pregnancy Immune Tolerance". The Journal of Immunology. 190 (6): 2650- ... These results suggest that hCG may be a link in the development of peritrophoblastic immune tolerance, and may facilitate the ...
2011-2014). Central focus is heat-tolerance of genes for kernel dry weight. UniformMu: A Transposon Resource for Mutagenesis in ... This sugar occupies a truly central position in vascular transport, carbon partitioning within the plant, and as a source of ...
... to eliminate T cells with self-reactive TCRs via processes of central tolerance e.g. negative selection and protect the body ... "Medullary Thymic Epithelial Stem Cells Maintain a Functional Thymus to Ensure Lifelong Central T Cell Tolerance". Immunity. 41 ... "Antigen presentation in the thymus for positive selection and central tolerance induction". Nature Reviews Immunology. 9 (12): ... "CCR7-Dependent Cortex-to-Medulla Migration of Positively Selected Thymocytes Is Essential for Establishing Central Tolerance". ...
Nature 351, 150 (1991). Central tolerance by deletion of immature T cells in TCR transgenic mice. Teho H. S., Kisielow, P., ... Kisielow, P., Blüthmann, H., Staerz, U. D., Steinmetz, M. and von Boehmer, H.: Tolerance in T cell receptor transgenic mice: ... Science 251, 1225 (1991). Peripheral tolerance by deletion of and reversible anergy in matureT cells. Borgulya, P., Kishi, H., ... Tolerance to histocompatibility determinants in tetraparental bone marrow chimeras. J. Exp. Med. 141, 322 (1975). Graft-versus- ...
The development of CentrAl. First International Conference on Damage Tolerance of Aircraft Structures. Delft, Netherlands. ... Its major advantages over conventional aluminum are: Better "damage tolerance" behavior, especially in impact and metal fatigue ... Central European Journal of Engineering. 2 (4): 603-611. Bibcode:2012CEJE....2..603M. doi:10.2478/s13531-012-0019-z. ISSN 1896- ... technology demonstrator that was partially made of FML and was based on the central fuselage of its ERJ-145 aircraft. Later, ...
December 2003). "An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms ...
Manu's central philosophy was tolerance and pluralism, and was cited across Southeast Asia. Early in this period, which ... Laws passed by the Parliament of India and other pre-existing central laws on subjects classified as central subjects are ... namely the Central Board of Direct Taxes and Central Board of Excise and Customs with effect from 1 January 1964. This ... The Central Board of Direct Taxes (CBDT) is a part of the Department of Revenue in the Ministry of Finance, Government of India ...
mTECs possess the ability to deal with these autoreactive clones via mediation of the processes of central tolerance, namely ... "Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance". The Journal ... "Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance". Nature Immunology. 11 (6): 512-9. doi ... "Medullary thymic epithelial stem cells maintain a functional thymus to ensure lifelong central T cell tolerance". Immunity. 41 ...
Manu's central philosophy was tolerance and pluralism, and was cited across Southeast Asia. Early in this period, which finally ... and most of Central and South America. The primary contrast between the two systems is the role of written decisions and ...
Core values such as tolerance, freedom of conscience and charity were central themes. God was portrayed as the loving Father ... Central contents, such as the Lutheran doctrine of justification, were called into question. The liturgy was considered ... After official rejection, Pietism quickly found its place in private homes, where the pietistic hymn was of central importance ... The central hymnbook of the Reformed Church was the Genevan Psalter, whose final (French) edition appeared in 1562. After ...
The first type of tolerance is central tolerance, that occurs in the thymus. T cells that bind (via their T cell receptor) to ... The second type of immunological tolerance is peripheral tolerance. Some self reactive T cells escape the thymus for a number ... This process is called tolerance. Dendritic cells also promote immunological tolerance, which stops the body from attacking ... When immunological tolerance fails, autoimmune diseases can follow. Phagocytes of humans and other jawed vertebrates are ...
Manu's central philosophy was tolerance and pluralism, and was cited across Southeast Asia. During the Muslim conquests in the ... Today, countries that have civil law systems range from Russia and Turkey to most of Central and Latin America. Anarchism has ... In civil law jurisdictions, a legislature or other central body codifies and consolidates the law. In common law systems, ... Haggard, Presidents, Parliaments and Policy, 71 Olson, The New Parliaments of Central and Eastern Europe, 7 See, e.g. ...
central government in rome was often far from civil and military commanders in the field, and local ambitions often dragged ... Slowly a movement for religious tolerance developed. Jewish legend describes Jewish dispersion from as early as the Book of ... Tabal was a Luwian speaking Neo-Hittite kingdom of South Central Anatolia which fell under Assyrian rule in 713 BC. The Medean ... Galatia was an area in central Anatolia, situated in northern and eastern Phrygia and Cappadocia, east and west of Ancyra ( ...
In the 16th century, there was a considerable degree of religious tolerance in Moravia because in the 15th century there had ... Originally mainly based on a Tyrolean dialect from the south-central German-speaking Europe from which many of them sprang in ... The Hutterites embarked on a series of migrations through central and eastern Europe. Nearly extinct by the 18th century, they ... The Schmiedeleut, however, made this transition earlier, where each household had a phone along with a central telephone for ...
One of his notable characteristics was his respect, tolerance and promotion of all churches. Referring to his experience in ... just off the Strand in central London. During his stays there, he developed a close friendship with his landlady, Margaret ... Franklin's advocacy for religious tolerance in France contributed to arguments made by French philosophers and politicians that ... "prophet of tolerance". He composed "A Parable Against Persecution", an apocryphal 51st chapter of Genesis in which God teaches ...
However, the precise panel gap tolerance found in Diplomat was beyond what the GM North American manufacturing plants could do ... September 1972 saw the introduction of a modified grille with OPEL script relocated from its left side to its central portion. ...
The central autonomous body that regulated Jewish life in Poland from the middle of the 16th to mid-18th century was known as ... The next year he issued a proclamation in which he stated that a policy of tolerance befitted "kings and rulers". Poland became ... As elsewhere in Central and Eastern Europe, the principal activity of Jews in medieval Poland was commerce and trade, including ... Approximately 7,600 Jews were held in a central transit camp in the city before deportation to Treblinka. Those deemed fit to ...
The Kangal is a traditional working breed of Central Anatolia. The name derives from that of the town and district of Kangal in ... tolerance either way for both sexes. The Kangal Shepherd Dog is not as heavy as some other Mastiff breeds, allowing it greater ... and the researchers propose that the breed may have been brought from Central Asia by the nomadic Turks. In October 2012, The ... the easternmost province of the Central Anatolia Region. The coat colour varies from pale fawn to wolf grey, always with a ...
Wang was unhappy with politics in Guizhou, and many members of the Liu family complained to Liu Xianshi about his tolerance of ... Yuan Shikai, then President of China, tried to intervene in the name of the central government, but his attempt was useless. On ... into believing that Tang's forces were simply passing through Guizhou on their way to aid revolutionary forces in Central China ...
After Charles Elton's use of food webs in his 1927 synthesis, they became a central concept in the field of ecology. Elton ... glycosides that are sequestered in the tissues of the Taylor's checkerspot butterfly larvae that have developed a tolerance for ... Fretwell, S. D. (1987). "Food chain dynamics: The central theory of ecology?" (PDF). Oikos. 50 (3): 291-301. doi:10.2307/ ... A central question in the trophic dynamic literature is the nature of control and regulation over resources and production. ...
Neutral group: This was a diverse group including most of the African countries, Central America, sub-Andean South America, ... Australia and Iran rallied in opposition to the UN's zero-tolerance approach in international drug policy. Their appeal was ... Treaties of the Central African Republic, Treaties of Chile, Treaties of the People's Republic of China, Treaties of Colombia, ... the former Secretary of the Permanent Central Narcotics Board and Drug Supervisory Body, operating under a mandate to give "an ...
Norway joins UN Special Rapporteur Pramilla Patten in calling on all parties to commit to a zero-tolerance policy for SGBV. ... protestors used stones and burnt tires to block central parts of the town in objection to the claim that the situation had ... "structured itself so as to bring the central government to its knees" and that talks could "only lead to the partition of ...
Pope Francis's visit to the Central African Republic, which is in a state of a civil war, made him the first pope to enter an ... "Pope Francis preaches tolerance on visit to Ur in Iraq". France 24. 6 March 2021. Retrieved 10 May 2021. Fordham, Alice (5 ... Kenya, Uganda, and Central African Republic (25 to 30 November 2015) Pope Francis stated, aboard the papal plane returning from ... "Pope Pleads For Tolerance As He Begins Baltics Visit In Lithuania". RadioFreeEurope/RadioLiberty. AFP, Pulse News Agency ...
Spanish) Ele é da Costa Rica, que fica na América Central. (Portuguese) 'He is from Costa Rica, which is in Central America.' ... tolerance' audacia (Spanish), audácia (Portuguese) 'audace' ocio (Spanish), ócio (Portuguese) 'leisure' continuo (Spanish), ... Portuguese) 'Santiago is the capital of Chile.' Él es de Costa Rica, que está en América Central. ( ... In the case of northern and central Peninsular Spanish, tú, usted, vosotros, and ustedes have more or less kept their original ...
The risks of tolerance, dependence, and withdrawal are very low when the drug is used for 2-4 weeks only, and lormetazepam is ... Ozawa M, Nakada Y, Sugimachi K, Akai T, Yamaguchi M (November 1991). "[Interaction of the hypnotic lormetazepam with central ... Tolerance to and loss of the sedative effects of benzodiazepine hypnotics can occur within 14 days of regular use. Some studies ... Those with a history of addiction may be at increased risk of problems of tolerance and dependence especially those with a past ...
However, four themes have a central role in the overall work. The first theme given treatment in the analysis is that the lust ... The cost of allowing for reasoned inquiry is the tolerance of intellectual disagreement, which in turn provokes scepticism and ...
The central government has not attempted to nullify these state laws, but stated that any death sentence for apostasy would ... calling instead for tolerance and acceptance of all religious minorities. In October 2013, 15-year-old Ahmad Sherwan from Erbil ... The Council of Ex-Muslims of Britain (CEMB) is the British branch of the Central Council of Ex-Muslims, who represent former ... Ehsan Jami, co-founder of the Central Committee for Ex-Muslims in the Netherlands in 2007, has received several death threats, ...
They also decided to film at Coober Pedy, a rough-and-tumble mining town in Central Australia which featured prominently in the ... "It is perhaps a pity that a film with a message of tolerance and acceptance for homosexuals should feel the need of what looks ... Rockhampton, Queensland: Central Queensland University. ISBN 978-1-875902-84-2. O'Regan, Tom (1996). Australian National Cinema ... a remote town in central Australia. After persuading his friends and fellow performers, Bernadette Bassenger (Terence Stamp), a ...
The Ontario Consultants on Religious Tolerance specifically limits the use of the term to religious groups that "have caused or ... became a central topic in U.S. court cases where the theory was used to try to justify the use of the forceful deprogramming of ... Robinson, B.A. (25 July 2007). "Doomsday, destructive religious cults". Ontario Consultants on Religious Tolerance. Retrieved ...
As the face for the Ajax Kids Club, a fan club for children initiated on 6 December 2000, Lucky is the central character in the ... As the key figure of the Ajax Kids Club, he appears at schools to promote tolerance, teamwork and companionship and the ...
It was the largest pride parade in central and Eastern Europe. The equality march has been held in Kraków since 2004. Before ... 2010, it was called a "tolerance march". In 2017, counter-demonstrators from All-Polish Youth directed participants towards a ...
Central to the success of the project was close collaboration with libraries, museums, and archives including the Boston ... Aronson, David (Fall 1996). "History Close to Home". Teaching Tolerance (10). Retrieved 17 October 2019. "W. Dean Eastman Named ... in the fall 1996 issue of Teaching Tolerance, published by the Southern Poverty Law Center. In 2001 Eastman was featured in the ... residential and entrepreneurial development expanded farther away from the central city, usually in bands of concentric ...
It is the traditional language of Zimbabwe's Shona people, who live in Zimbabwe's central and eastern provinces. Shona has a ... Sparks, Allister (1984-01-04). "15,000-Strong Afrikaner Community Finds Tolerance in Zimbabwe". The Washington Post. Retrieved ... Kunda is a Bantu language spoken in eastern Zimbabwe, in the Mashonaland Central and Mashonaland West provinces. It was spoken ... Standard Shona is derived from the Central Shona dialects, especially Karanga and Zezuru. According to Ethnologue, Shona is ...
His Chishti Order went on to become the most influential Sufi lineage in India, although other orders from Central Asia and ... affecting the feelings of security and tolerance amongst Indian Muslims. However, these allegations are not universally ... The district police, Rapid Action Force, Central Reserve Police Force and Border Security Force all failed to stop the mob ... Around the 10th century, Muslim Central Asian nomadic empire, the Ghaznavids, under Mahmud of Ghazni (971-1030 CE), was the ...
Other South Asian Stone Age sites, such as the Bhimbetka rock shelters in central Madhya Pradesh and the Kupgal petroglyphs of ... It mandates equal treatment and tolerance of all religions. India does not have an official state religion; it enshrines the ... During the 14th-17th centuries, when North India was under Muslim rule, the Bhakti movement swept through Central and Northern ... Religious diversity and religious tolerance are both established in the country by the law; the Constitution of India has ...
"Hypocrisy of Dubai's World Tolerance Summit". Human Rights Watch. 2018-11-14. Retrieved 2021-04-06. "United Arab Emirates says ... as a federal system is that a significant percentage of each emirate's revenues should be devoted to the UAE central budget. ...
The intercepted letter was sent to Güshi Khan who used it as a pretext to invade central Tibet in 1639 to attack them both, the ... out of compassion and his vision of tolerance for other religious schools, refused to give permission for more warfare in his ... In 1856, a child was born in south central Tibet amidst all the usual extraordinary signs. He came to the notice of the search ... The 4th was then born in Mongolia as the great-grandson of Altan Khan, thus cementing strong ties between Central Asia, the ...
... s are utilised in central heating and cooling systems that rely on flow of water through the system. ... they also offer improved dirt tolerance thanks to a simplified water path and some the capability to report flow rates to the ...
Due to its tolerance of infertile soils, it can be found on exposed ridges, around bog margins, and other poorly drained land ... Phyllocladus toatoa can be found in lowlands and montane forests including the central North Island and northwards. It is ...
The figure of Jesus Christ as the son of God and his teachings of tolerance and forgiveness had caused God to evolve from an ... Roland Greene states that "the Psalters deserve a central location in our understanding of what sixteenth-century poets did - ...
Over the past decade, a scholarly consensus has emerged that that democracy in Central and Eastern Europe (CEE) is ... tolerance for LGBT people) are more important in explaining how democracies turn authoritarian compared to economic inequality ... Greskovitz, Béla (2015). "The Hollowing and Backsliding of Democracy in East-Central Europe". Global Policy. 6 (1): 28-37. doi: ... Licia Cianetti; James Dawson; Seán Hanley (2018). "Rethinking "democratic backsliding" in Central and Eastern Europe - looking ...
Tolerance is generally accepted to be an active process and, in essence, a learning experience for T cells. ... Immunologic tolerance is a state of immune unresponsiveness specific to a particular antigen or set of antigens induced by ... Central (Intrathymic) Mechanisms of Tolerance. The chief mechanism of T-cell tolerance is the deletion of autoreactive T cells ... donor-specific tolerance has been termed prope tolerance [33] (from Latin prope "near") or minimal immunosuppression tolerance. ...
Presently our aim was to investigate the development of tolerance to the antinociceptive effects of NSAIDs analgine, ketorolac ... Antinociception following systemic administra-tion of non-steroidal anti-inflammatory drugs (N SAIDs) also exhibit tolerance. ... ss-tolerance to the antinociceptive effect of N SAIDs. In other words, the ... the midbrain periaqueductal gray matter and rostral ventro-medial medulla induce antinociception with development of tolerance ...
Announcing the new Central Statistical Monitoring / Quality Tolerance Limits - Special Interest Group (CSM SIG) Mar 15, 2021, ... The Central Statistical Monitoring / Quality Tolerance Limits - Special Interest Group (CSM SIG) has formed itself to create a ... The use of Centralised Statistical Monitoring and Quality Tolerance Limits are fundamental components of Risk Based Quality ... However, although there has been much commentary published on the operational application of Central Monitoring & QTLs, there ...
A faulty central tolerance sows the seeds for autoimmune disease, while faulty peripheral tolerance lead to its eruption. ... Central tolerance. Lymphocytes learn to react with antigens during lymphopoiesis in central lymphoid organs, thymus, and bone ... The "upper level" of central tolerance develops primarily in fetal life, and the "lower level" of peripheral tolerance develops ... How tolerance is established and may fail. Generation of immune repertoires in central lymphoid organs, thymus, and bone marrow ...
The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity. Domínguez-Andrés Jorge ... In contrast, induction of trained immunity by b-glucan counteracted tolerance induced in a model of human endotoxemia by ... The role of itaconate was further validated by IRG1 and SDH polymorphisms that modulate induction of tolerance and trained ... These data demonstrate the importance of the IRG1-itaconateSDH axis in the development of immune tolerance and training and ...
... this occurs in both central (bone marrow, thymus) and peripheral (spleen, lymph nodes) lymphoid organs and tissues ... Induction of tolerance requires education of both B and T cells, ... Central and Peripheral tolerance occur in tandem, in the case ... 2. CENTRAL & PERIPHERAL TOLERANCE 3. IMMUNE REGULATION IN PREGNANCY 4. BREAKING TOLERANCE: AUTOIMMUNITY & DYSREGULATION 5. ... Central vs. Peripheral Tolerance. *Induction of tolerance requires education of both B and T cells, which occurs in both ...
A central role for active tolerance in transplantation-tolerance is also supported by recent data showing that genuine ... Induction of donor-specific non-responsiveness (i.e., immunological tolerance) to transplants would solve these problems and ... In experimental settings, this attractive approach allows development of genuine immunological tolerance to donor tissues using ... lead to immunological tolerance to organs of the same donor. However, a careful analysis of the literature, performed here, ...
... tolerance, tol, and return TRUE if all are within tolerance.,/p,. Given a vector of experimental data, D, and a vector of truth ... tolerance, tol, and return TRUE if all are within tolerance.,/w:t,,/w:r,,/w:p,,/w:body,,/w:document,},{partUri:/matlab/ ... Should be return FALSE if any +/- errors (D-T) are outside a given (positive) tolerance ... Find the treasures in MATLAB Central and discover how the community can help you! ...
https://gracemine.org/wp-content/uploads/2021/08/Zero-Tolerance-Hatred.mp3. ...
Risk tolerance.. An investor with higher risk tolerance may be more willing to accept greater market volatility in the pursuit ... Your Shifting Risk Tolerance. When you created your investment strategy, your asset allocation should have reflected your goals ... An investor with a lower risk tolerance may be willing to forgo some potential return in favor of investments that attempt to ... The financial professionals of Central Coast Wealth Management are Registered Representatives and Investment Adviser ...
Central transplantation tolerance through hemopoietic chimerism initially requires inhibition of allogeneic stem cell or bone ... Combinations of anti-LFA-1, everolimus, anti-CD40 ligand, and allogeneic bone marrow induce central transplantation tolerance ... and allogeneic bone marrow induce central transplantation tolerance through hemopoietic chimerism, including protection from ...
How to add tolerance to my code ?. Learn more about flipud, matrix manipulation, for loop, tolerance, precision, find, matrix, ... I think the reason is that I need to add a tolerance to the result of desired_line so Matlab can find it and add it to the ... so i need to add a tolerance to the desired_line and then add it to the desired_line_matrix !!! ... But I think using your first answer is going to work for me if i can set the right tolerance. ...
How to calculate/plot a tolerance band in two... Learn more about signal processing, curves, tolerance, plot MATLAB ... Find the treasures in MATLAB Central and discover how the community can help you! ... I have a time signal and want to add a value-tolerance-band as well as a time-tolerance band. So to say a sepcific y offset in ... for z1 = 1:Dist %shift as often as needed for wanted time-delay-tolerance ...
Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance.. ... Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance. Cell Rep. 2016 10 04; 17(2):387-398. ...
Central nervous system effects of meclizine and dimenhydrinate: evidence of acute tolerance to antihistamines.. Manning, C; ... The data suggest the possibility that acute tolerance to central nervous system impairment develops with multiple doses of ... Sistema Nervioso Central/efectos de los fármacos Dimenhidrinato/farmacología Meclizina/farmacología Adolescente Adulto Método ...
Kyewski, B. & Klein, L. A central role for central tolerance. Annu. Rev. Immunol. 24, 571-606 (2006). ... Immunol. 305, 51-66 (2006). References 14-16 provide a comprehensive discussion of the various mechanisms of T-cell tolerance. ... Thurman, J. M. & Holers, V. M. The central role of the alternative complement pathway in human disease. J. Immunol. 176, 1305- ... Sakaguchi, S. & Sakaguchi, N. Regulatory T cells in immunologic self-tolerance and autoimmune disease. Int. Rev. Immunol. 24, ...
Religious Leaders, Germany: The new Central Mosque in Duisburg in Germany: built in consensus. Posted in Best practices , 12- ... India: Hubertus Hoffmann Meets a Miracle of Tolerance and an Economic Boom. German entrepreneur and geostrategist Dr. Hubertus ... Religious Leaders, Germany: The new Central Mosque in Duisburg in Germany: built in consensus. *Mission ... Local from Germany: The new Central Mosque in Duisburg in Germany: built in consensus ...
how to find the closest values with tolerance in... Learn more about closest values, matrix, value tolerance, closest values in ... Find the treasures in MATLAB Central and discover how the community can help you! ... Hi everyone, i have a problem finding values with tolerance in a matrix.In more detail, i have a 601x2201 matrix that contains ... how to find the closest values with tolerance in a matrix given a specific value. ...
Van Graefe first described central retinal artery occlusion (CRAO) as an embolic event to the central retinal artery in a ... Central retinal artery occlusion and retinal tolerance time. Ophthalmology. 1980 Jan. 87(1):75-8. [QxMD MEDLINE Link]. ... Central retinal artery occlusion (CRAO) first was described by Van Graefe in 1859 as an embolic event to the central retinal ... encoded search term (Central Retinal Artery Occlusion (CRAO)) and Central Retinal Artery Occlusion (CRAO) What to Read Next on ...
As incidents of hate crimes continue to mount, a mobile museum is coming to teach tolerance and combat antisemitism and other ... "Education and training are central to promoting tolerance and respect for others," said Seawright. "Combined with vigilant law ... As incidents of hate crimes continue to mount, a mobile museum is coming to teach tolerance and combat antisemitism and other ... I look forward to the Mobile Museum of Tolerance visiting the communities I represent on the Upper East Side, Yorkville and ...
Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic ... Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic ... Autoimmunity, Central Immune Tolerance, Medullary Thymic Epithelial Cells, NF-{kappa}B, Conditional Gene Targeting, Animals, ... Medullary thymic epithelial cells (mTECs) contribute to self-tolerance by expressing and presenting peripheral tissue antigens ...
Central England Co-op reinforces zero tolerance crime campaign after shoplifter threatens staff in Rugeley store. Posted by rob ... Central England Co-operative is one of the largest independent retail co-operative societies in the UK with interests in food, ... Recent figures from Central England Co-op showed that nearly 12,000 incidents have been reported so far this year including 81 ... Central England Co-op has reaffirmed its message that violence and aggression towards staff will not be tolerated after ...
C. is a central nervous system depressant. D. stimulates the heart and increases respiration. ... is not easy to develop a tolerance to. B. increases hunger signals. ... Nicotine A. is not easy to develop a tolerance to. B. increases hunger signals. C. is a central nervous system depressant. D. ... Nicotine A. is not easy to develop a tolerance to. B. increases hunger signals. C. is a central nervous system depressant. D. ...
The idea is that from time to time, I will review new book chapters and journal articles written about education in Central ... Welcome to the first in a new occasional series on the blog called New education research on Central Asia. ... Diloro IskandarovaeducationNew education research on Central AsiaTajikistantolerance Post navigation. Previous Central Asias ... So - back to new research from Central Asia. The book chapter Im reviewing today is called "Problems of forming tolerance in ...
Central tolerance is impaired in the middle-aged thymic environment. Aging Cell. 2022 Jun;21(6):e13624. PMID: 35561351 ... Age-Related Changes in Thymic Central Tolerance. Front Immunol. 2021 Apr 22;12:676236. (Review) ... 2013) Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs. Nat Commun. 2013 ... Richard Wood - Nucleotide excision repair, DNA crosslink repair, role of polymerases in DNA damage tolerance ...
Laan M, Peterson P. The many faces of aire in central tolerance. Front Immunol. 2013 Oct 11;4:326. doi: 10.3389/fimmu. ... Alterations of the autoimmune regulator transcription factor and failure of central tolerance: APECED as a model. Expert Rev ... Citation on PubMed or Free article on PubMed Central. *De Martino L, Capalbo D, Improda N, DElia F, Di Mase R, DAssante R, ... Citation on PubMed or Free article on PubMed Central. *De Martino L, Capalbo D, Improda N, Lorello P, Ungaro C, Di Mase R, ...
Second, the small central allocation depends on the risk tolerance. As the risk tolerance shrinks from an EUD of 5 patients, ... The total size of the required stockpile, summed across the central and 8 HSR stockpiles, decreases as risk tolerance (EUD)... ... The total size of the optimal stockpile, summed across the central and 8 HSR stockpiles, decreases as risk tolerance... ... The total size of the optimal stockpile, summed across the central and 8 HSR stockpiles, decreases as risk tolerance increases ...
Is central Europe afraid of religious tolerance? * Published in: Global Extremes Germany: Is banning far-right groups enough? ...
Antigen presentation in the thymus for positive selection and central tolerance induction. ...
Nemazee D (October 2006). "Receptor editing in lymphocyte development and central tolerance". Nature Reviews. Immunology. 6 (10 ...
  • This immunological tolerance was postulated over 50 years ago, but its multifactorial basis is still controversial. (bmj.com)
  • Induction of donor-specific non-responsiveness (i.e., immunological tolerance) to transplants would solve these problems and would substantially ameliorate patients' quality of life. (frontiersin.org)
  • It has been proposed that bone marrow or hematopoietic stem-cell transplantation, and resulting (mixed) hematopoietic chimerism, lead to immunological tolerance to organs of the same donor. (frontiersin.org)
  • In experimental settings, this attractive approach allows development of genuine immunological tolerance to donor tissues using clinically relevant conditioning regimens. (frontiersin.org)
  • Furthermore, we discovered that children and adults who got KD during years as a child without developing CAA didn't react to the Fc proteins antigens and play a central part in keeping immunological tolerance [1,2]. (forgetmenotinitiative.org)
  • However, during the study of achieving immune tolerance, ways in which to induce states of "partial tolerance" have been discovered, in which lower-than-conventional amounts of ongoing pharmacologic immunosuppression are needed. (medscape.com)
  • Aim: Repeated microinjections of non-opioid an-algesics into the midbrain periaqueductal gray matter and rostral ventro-medial medulla induce antinociception with development of tolerance. (scirp.org)
  • Combinations of anti-LFA-1, everolimus, anti-CD40 ligand, and allogeneic bone marrow induce central transplantation tolerance through hemopoietic chimerism, including protection from chronic heart allograft rejection. (novartis.com)
  • The findings suggest that treatment with PD-1- and PD-1L-specific reagents may induce tolerance in patients with autoimmune disease, especially those with HemA who also possess inhibiting antibodies. (jci.org)
  • Economists expect inflation to remain above the central bank's upper tolerance band in the coming months. (financialexpress.com)
  • Separately, minutes from the Fed's September meeting will give clues into the central bank's tolerance for economic pain. (gulfnews.com)
  • It also raises inflation, which is floating too close for comfort to the upper end of the central bank's 2.5-6.5% tolerance band. (economist.com)
  • India's headline retail inflation has remained above the central bank's upper tolerance band for eight months. (brecorder.com)
  • The Council also affirmed the central bank's commitment to ensuring market stability, in addition to its primary objective of price stability. (xpatloop.com)
  • The "leakiness" of this process requires back up by peripheral tolerance. (bmj.com)
  • The "upper level" of central tolerance develops primarily in fetal life, and the "lower level" of peripheral tolerance develops postnatally as a backup process. (bmj.com)
  • A faulty central tolerance sows the seeds for autoimmune disease, while faulty peripheral tolerance lead to its eruption. (bmj.com)
  • Figure 2: Central and peripheral tolerance mechanisms. (nature.com)
  • Medullary thymic epithelial cells (mTECs) contribute to self-tolerance by expressing and presenting peripheral tissue antigens for negative selection of autoreactive T cells and differentiation of natural regulatory T cells. (mdc-berlin.de)
  • Immunologic tolerance is a state of immune unresponsiveness specific to a particular antigen or set of antigens induced by previous exposure to that antigen or set. (medscape.com)
  • Reproducibility of glucose tolerance in 101 nondiabetic women. (cdc.gov)
  • A low birth weight, when a child becomes obese, has been linked to the increased central distribution of fat, decreased glucose tolerance and the emergence of metabolic syndrome 10.11 . (bvsalud.org)
  • Find the treasures in MATLAB Central and discover how the community can help you! (mathworks.com)
  • Generation of immune repertoires in central lymphoid organs, thymus, and bone marrow is accompanied by deletion of self reactive lymphocytes by apoptosis. (bmj.com)
  • Lymphocytes learn to react with antigens during lymphopoiesis in central lymphoid organs, thymus, and bone marrow. (bmj.com)
  • In general, T-cell tolerance is effected 'centrally' in the thymus, or peripherally through the action of regulatory T cells or other mechanisms. (nature.com)
  • The repertoire of T cells is primarily formed in the thymus through positive and negative selection of developing thymocytes that are critical for establishing central tolerance. (who.int)
  • This atrophy does not necessarily result in dysfunction of the thymus since the organ micro architecture is preserved and maintains negative selection, thus avoiding the development of tolerance to the pathogen during the establishment of protective immunity. (who.int)
  • Pernia-Andrade, A.J., Tortorici, V. and Venegas, H. (2002) Induction of opioid tolerance by lysine-acetylsalicylate in rats. (scirp.org)
  • Tortorici, V. and Vanegas, H. (2000) Opioid tolerance in- duced by metamizol (dipyrone) microinjections into the periaqueductal gray of rats. (scirp.org)
  • This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. (medlineplus.gov)
  • Induction of immunologic tolerance has been achieved and studied in numerous laboratory animal models, but it remains an elusive goal in clinical organ transplantation and in the management of autoimmune disease in humans. (medscape.com)
  • Tolerance fails because of the interaction of a wrong environment with the wrong genes, resulting in autoimmune disease. (bmj.com)
  • Several layers of complementary mechanisms ensure tolerance to self-antigens. (frontiersin.org)
  • Central England Co-op was named Leading Co-op of the Year by Co-operatives UK in 2021. (centralengland.coop)
  • Since such cells would cause devastating autoimmune pathology, the natural mechanisms involved in the induction of self-tolerance play a crucial role in the survival of the species ( Waldmann, 2010 ). (frontiersin.org)
  • It appears very attractive to manipulate the mechanisms involved in self-tolerance in order to make them prevent allograft rejection. (frontiersin.org)
  • While it is undisputed that late embryogenesis abundant (LEA) proteins play a key role in the tolerance of plants and many anhydrobiotic organisms to water limitation, the molecular mechanisms are not well understood. (researchgate.net)
  • The molecular genetic pathways of drought stress tolerance uncovered in this study, as well as the DEGs co-localized with DT-related QTLs and introgressed intervals, will serve as useful resources for further functional dissection of the molecular mechanisms of drought stress response in rice. (biomedcentral.com)
  • Central retinal artery occlusion (CRAO) first was described by Van Graefe in 1859 as an embolic event to the central retinal artery in a patient with endocarditis. (medscape.com)
  • Laboratory studies may be helpful in determining the etiology of central retinal artery occlusion (CRAO) but do not affect ED treatment. (medscape.com)
  • Farris W, Waymack JR. Central Retinal Artery Occlusion. (medscape.com)
  • Madike R, Cugati S, Chen C. A review of the management of central retinal artery occlusion. (medscape.com)
  • Fraser SG, Adams W. Interventions for acute non-arteritic central retinal artery occlusion. (medscape.com)
  • Schrag M, Youn T, Schindler J, Kirshner H, Greer D. Intravenous Fibrinolytic Therapy in Central Retinal Artery Occlusion: A Patient-Level Meta-analysis. (medscape.com)
  • Hattenbach LO, Kuhli-Hattenbach C, Scharrer I, Baatz H. Intravenous thrombolysis with low-dose recombinant tissue plasminogen activator in central retinal artery occlusion. (medscape.com)
  • Acute Central Retinal Artery Occlusion Treated with Intravenous Recombinant Tissue Plasminogen Activator. (medscape.com)
  • Cohen JE, Moscovici S, Halpert M, Itshayek E. Selective thrombolysis performed through meningo-ophthalmic artery in central retinal artery occlusion. (medscape.com)
  • Atebara NH, Brown GC, Cater J. Efficacy of anterior chamber paracentesis and Carbogen in treating acute nonarteritic central retinal artery occlusion. (medscape.com)
  • The European Central Bank should spell out its tolerance for overshooting its inflation target, ECB policymaker Francois Villeroy de Galhau said on Tuesday. (reuters.com)
  • A rise in inflation will force the Central Bank to keep raising interest rates. (economist.com)
  • The US Treasury yield curve inversion deepened further, as Fed Chair Jerome Powell said central bank officials were "strongly resolved" to bringing down inflation from four-decade highs and "will keep at it until the job is done. (brecorder.com)
  • The Monetary Council will continue the cycle of interest rate hikes until the outlook for inflation stabilises around the central bank target and inflation risks become evenly balanced on the horizon of monetary policy, they added. (xpatloop.com)
  • He said inflation could start slowing back down to the central bank tolerance band next year. (xpatloop.com)
  • Central transplantation tolerance through hemopoietic chimerism initially requires inhibition of allogeneic stem cell or bone marrow (BM) rejection, as previously achieved in murine models by combinations of T cell costimulation blockade. (novartis.com)
  • Transplantation tolerance could eliminate many of the adverse events associated with immunosuppressive agents. (medscape.com)
  • Nonetheless, immune tolerance remains the holy grail of transplantation immunology and clinical transplantation. (medscape.com)
  • L) is more sensitive to drought stress than other cereals, and large genotypic variation in drought tolerance (DT) exists within the cultivated rice gene pool and its wild relatives. (biomedcentral.com)
  • IITA in collaboration with national partners has thus employed a sequential selection scheme to incorporate both drought tolerance and Striga resistance in topical maize hybrids using reliable screening protocols. (iita.org)
  • Immune tolerance and autoimmunity are important clinically. (bmj.com)
  • Figure 1 illustrates how tolerance is established and maintained and how it fails with ensuing autoimmunity. (bmj.com)
  • The role of itaconate was further validated by IRG1 and SDH polymorphisms that modulate induction of tolerance and trained immunity in human monocytes. (diagenode.com)
  • Acute activation of myeloid cells induced itaconate synthesis, which subsequently mediated innate immune tolerance in human monocytes. (diagenode.com)
  • Central nervous system effects of meclizine and dimenhydrinate: evidence of acute tolerance to antihistamines. (bvsalud.org)
  • The data suggest the possibility that acute tolerance to central nervous system impairment develops with multiple doses of dimenhydrinate . (bvsalud.org)
  • Acute obstruction of the central retinal artery results in inner layer edema and death of the ganglion cell nuclei. (medscape.com)
  • Visual prognosis following treatment of acute central retinal artery obstruction. (medscape.com)
  • ATSDR has calculated an acute inhalation MRL of 0.6 ppm based on a LOAEL of 300 ppm in an acute study in humans that evaluated the effects of methylene chloride on the central nervous system (Winneke 1974). (cdc.gov)
  • Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance. (uchicago.edu)
  • Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis. (wjgnet.com)
  • IMSEAR at SEARO: Thymic Atrophy during Infection as a Host Response to Avoid Tolerance to Persistent Pathogens. (who.int)
  • ABSTRACT Central-line-associated bloodstream infection (CLABSI) is one of the most important problems in intensive care units (ICUs) worldwide. (who.int)
  • de Brito CS, de Brito DV, Abdallah VO, Gontijo Filho PP. Occurrence of bloodstream infection with different types of central vascular catheter in critically neonates. (cdc.gov)
  • Effect of Catheter Dwell Time on Risk of Central Line-Associated Bloodstream Infection in Infants. (cdc.gov)
  • Dwell time and risk of central-line-associated bloodstream infection in neonates. (cdc.gov)
  • Shalabi MA, Yoon M, Aziz E, Shoo K, Shah L, Prakesh S. Risk of Infection Using Peripherally Inserted Central and Umbilical Catheters in Preterm Neonates. (cdc.gov)
  • Umbilical Venous Catheters and Peripherally Inserted Central Catheters: Are They Equally Safe in VLBW Infants? (cdc.gov)
  • Association between Peripherally Inserted Central Venous Catheter Insertion Site and Complication Rates in Preterm Infants. (cdc.gov)
  • As the central theme of WHO's work in 2020 came to be defined by its response to the pandemic of coronavirus disease (COVID-19), this new reality also had a profound impact on staff members. (who.int)
  • Indians see religious tolerance as a central part of who they are as a nation. (pewresearch.org)
  • Imagine that: in the name of religious tolerance this guy just could not tolerate the core faith found in Australia and at a time when one of its two most holy days is being celebrated. (billmuehlenberg.com)
  • In other words, the "non-opioid tolerant" rats showed cross-tolerance to morphine. (scirp.org)
  • Cases were filed by the Central Commission for Discipline Inspection and the Ministry of Supervision to look into serious disciplinary violations by some senior Party officials. (uncac.cn)
  • A crackdown on hedonism and extravagance in a drive to improve professionalism is to go on in Xi's second term, an unidentified official from the Central Commission for Discipline Inspection told the official Xinhua news agency. (straitstimes.com)
  • Variations in central venous catheter-related infection risks among Canadian neonatal intensive care units. (cdc.gov)
  • Breschan C, Platzer M, Jost R, Schaumberger F, Stettner H, Likar R. Comparison of catheter-related infection and tip colonization between internal jugular and subclavian central venous catheters in surgical neonates. (cdc.gov)
  • The notion of "not my problem" and tolerance for preventable disease in underserved parts of the world has created a global vulnerability for infection outbreaks. (nytimes.com)
  • Antinociception following systemic administra-tion of non-steroidal anti-inflammatory drugs (N SAIDs) also exhibit tolerance. (scirp.org)
  • Kliemann and Oliveira 19 emphasized the importance of RPD relining because even if the patient is undergoing resorption stability, due to a systemic disease the physiologic tolerance balance may be altered and functional forces become damaging. (bvsalud.org)
  • When you created your investment strategy, your asset allocation should have reflected your goals, time horizon, and tolerance for risk. (centralcoastwm.com)
  • In any case, each person's circumstances are unique and any strategy ought to reflect your particular risk tolerance, time horizon, and goals. (cfswi.com)
  • Exposure to excessive amounts of manganese may cause health effects such as liver, lung, and kidney damage and central nervous system effects. (cdc.gov)
  • The use of Centralised Statistical Monitoring and Quality Tolerance Limits are fundamental components of Risk Based Quality Management as laid out in ICH-E6(R2) Good Clinical Practice. (psiweb.org)
  • It is one of the fundamental components of tolerance. (mexico-with-heart.com)
  • The financial professionals of Central Coast Wealth Management are Registered Representatives and Investment Adviser Representatives with/and offers securities and advisory services offered through Commonwealth Financial Network ® , Member FINRA / SIPC , a Registered Investment Adviser. (centralcoastwm.com)
  • Tolerance is generally accepted to be an active process and, in essence, a learning experience for T cells. (medscape.com)
  • present data on a possible mechanism for tolerance to factor VIII in healthy individuals and the immune response in patients, involving a role of PD-1 and T regulatory cells. (jci.org)
  • Our data reveal a crosstalk mechanism between classical and alternative NF-{kappa}B pathways that tightly controls the development of mature mTECs to ensure self-tolerance. (mdc-berlin.de)
  • Abscisic acid (ABA) is an important phytohormone involved in drought stress tolerance in plants, whose mechanism in plant DT is relatively clear. (biomedcentral.com)
  • AIRE expands: new roles in immune tolerance and beyond. (medlineplus.gov)
  • The practice is mostly carried out by traditional circumcisers, who often play other central roles in communities, such as attending childbirths. (who.int)
  • Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. (nih.gov)
  • Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). (medlineplus.gov)
  • Selective introgression of DT donor segments into a drought-sensitive (DS) elite recurrent parent by backcrossing is an effective way to improve drought stress tolerance in rice. (biomedcentral.com)
  • Role of impaired central tolerance to a-myosin in inflammatory heart disease. (harvard.edu)
  • Transplant tolerance is defined as a state of donor-specific unresponsiveness without a need for ongoing pharmacologic immunosuppression. (medscape.com)
  • As incidents of hate crimes continue to mount, a mobile museum is coming to teach tolerance and combat antisemitism and other forms of discrimination, thanks to $1.5 million grant to the Simon Wiesenthal Center, Assembly Member Rebecca Seawright announced. (ourtownny.com)
  • The state-of-the-art mobile education center will use an interactive theater and other technology to teach tolerance and combat all forms of discrimination by focusing on the Holocaust as well as an American civil rights experience as critical teaching moments. (ourtownny.com)
  • The genetic variants involved in regulating T-cell and B-cell tolerance predispose to multiple autoimmune disorders. (nature.com)
  • 3 In 1991, the World Health Assembly adopted Resolution WHO 44.8, recognizing "effective case management as the central intervention for tuberculosis control", and recommending the strengthening of national tuberculosis programmes by introducing short course chemotherapy and improving the treatment management system. (who.int)
  • Presently our aim was to investigate the development of tolerance to the antinociceptive effects of NSAIDs analgine, ketorolac, and xefocam microinjected into cen-tral nucleus of amygdala (Ce) in rats. (scirp.org)
  • Con-clusions: Our data confirmed the suggestion that NSAIDs interact with endogenous opioid systems, which likely play a key role in the development of tolerance to the antinociceptive effects of NSA IDs. (scirp.org)
  • Current varieties have excellent cold tolerance, which reduced the effects of last winter's unusually cold weather. (amscl.org)
  • These data demonstrate the importance of the IRG1-itaconateSDH axis in the development of immune tolerance and training and highlight the potential of b-glucaninduced trained immunity to revert immunoparalysis. (diagenode.com)
  • This study aims to investigate the gender aspect of young people's attitude (students who just started their university education) from Eastern and Central European countries to entrepreneurship. (businessperspectives.org)
  • Independent and neutral with regard to all political and religious orientations, Tolerance.ca ® aims to promote awareness of the major democratic principles on which tolerance is based. (tolerance.ca)
  • Ultimately, the Ombudsman aims to foster a better working environment in which core institutional values such as respect, integrity, tolerance and non-discrimination are upheld. (who.int)
  • Several applications, including the location estimator case $(k = 1)$ for elliptical distributions and the construction of multivariate (not necessarily connected) tolerance zones, are also given. (projecteuclid.org)
  • This production zones need maize cultivars that combine tolerance to the two stresses. (iita.org)
  • Amid fears in global financial markets about a withdrawal of central-bank stimulus that has pushed money into red-hot emerging markets in recent years, Brazil's most immediate concern is its current-account deficit. (economist.com)
  • Risk tolerance. (centralcoastwm.com)
  • An investor with higher risk tolerance may be more willing to accept greater market volatility in the pursuit of potential returns. (centralcoastwm.com)
  • An investor with a lower risk tolerance may be willing to forgo some potential return in favor of investments that attempt to limit price swings. (centralcoastwm.com)
  • Understand the concepts of horizon, compounding, and risk tolerance, and create an investment plan. (centralcoastwm.com)
  • In this article, PA 4 Finance Founder, Andrew Baker, shares his advice on kick-starting your savings and calculating your personal risk tolerance. (aapa.org)
  • How to calculate/plot a tolerance band in two dimensions? (mathworks.com)
  • I have a time signal and want to add a value-tolerance-band as well as a time-tolerance band. (mathworks.com)
  • The central bank has raised interest rates by a total of 140 basis points between May and August, with economists now assessing the possibility of terminal repo rate in 6.25%-6.50% band. (brecorder.com)
  • Their task is to see whether the policies of the central authorities are faithfully implemented, particularly whether there are violations of political discipline and rules, including the eight-point decision, whether the selection of officials is rules-based and whether there is corruption. (uncac.cn)
  • The CCDI official also warned that officials still suffer from excess "formalism" and "bureaucratism", Communist Party terms for failing to carry out central party orders. (straitstimes.com)