Central Nervous System Vascular Malformations
Vascular Malformations
A spectrum of congenital, inherited, or acquired abnormalities in BLOOD VESSELS that can adversely affect the normal blood flow in ARTERIES or VEINS. Most are congenital defects such as abnormal communications between blood vessels (fistula), shunting of arterial blood directly into veins bypassing the CAPILLARIES (arteriovenous malformations), formation of large dilated blood blood-filled vessels (cavernous angioma), and swollen capillaries (capillary telangiectases). In rare cases, vascular malformations can result from trauma or diseases.
Arteriovenous Malformations
Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They usually are crooked, dilated, and with thick vessel walls. A common type is the congenital arteriovenous fistula. The lack of blood flow and oxygen in the capillaries can lead to tissue damage in the affected areas.
Intracranial Arteriovenous Malformations
Congenital vascular anomalies in the brain characterized by direct communication between an artery and a vein without passing through the CAPILLARIES. The locations and size of the shunts determine the symptoms including HEADACHES; SEIZURES; STROKE; INTRACRANIAL HEMORRHAGES; mass effect; and vascular steal effect.
Central Nervous System
Hemangioma
Telangiectasia, Hereditary Hemorrhagic
An autosomal dominant vascular anomaly characterized by telangiectases of the skin and mucous membranes and by recurrent gastrointestinal bleeding. This disorder is caused by mutations of a gene (on chromosome 9q3) which encodes endoglin, a membrane glycoprotein that binds TRANSFORMING GROWTH FACTOR BETA.
Hemangioma, Cavernous, Central Nervous System
A vascular anomaly composed of a collection of large, thin walled tortuous VEINS that can occur in any part of the central nervous system but lack intervening nervous tissue. Familial occurrence is common and has been associated with a number of genes mapped to 7q, 7p and 3q. Clinical features include SEIZURES; HEADACHE; STROKE; and progressive neurological deficit.
Lymphatic Abnormalities
Central Nervous System Diseases
Hemangioma, Cavernous
A vascular anomaly that is a collection of tortuous BLOOD VESSELS and connective tissue. This tumor-like mass with the large vascular space is filled with blood and usually appears as a strawberry-like lesion in the subcutaneous areas of the face, extremities, or other regions of the body including the central nervous system.
Double-Balloon Enteroscopy
Arteriovenous Fistula
An abnormal direct communication between an artery and a vein without passing through the CAPILLARIES. An A-V fistula usually leads to the formation of a dilated sac-like connection, arteriovenous aneurysm. The locations and size of the shunts determine the degree of effects on the cardiovascular functions such as BLOOD PRESSURE and HEART RATE.
Sclerotherapy
Port-Wine Stain
A vascular malformation of developmental origin characterized pathologically by ectasia of superficial dermal capillaries, and clinically by persistent macular erythema. In the past, port wine stains have frequently been termed capillary hemangiomas, which they are not; unfortunately this confusing practice persists: HEMANGIOMA, CAPILLARY is neoplastic, a port-wine stain is non-neoplastic. Port-wine stains vary in color from fairly pale pink to deep red or purple and in size from a few millimeters to many centimeters in diameter. The face is the most frequently affected site and they are most often unilateral. (From Rook et al., Textbook of Dermatology, 5th ed, p483)
Angiodysplasia
Acquired degenerative dilation or expansion (ectasia) of normal BLOOD VESSELS, often associated with aging. They are isolated, tortuous, thin-walled vessels and sources of bleeding. They occur most often in mucosal capillaries of the GASTROINTESTINAL TRACT leading to GASTROINTESTINAL HEMORRHAGE and ANEMIA.
Klippel-Trenaunay-Weber Syndrome
Skin Diseases, Vascular
Central Nervous System Neoplasms
Arnold-Chiari Malformation
A group of congenital malformations involving the brainstem, cerebellum, upper spinal cord, and surrounding bony structures. Type II is the most common, and features compression of the medulla and cerebellar tonsils into the upper cervical spinal canal and an associated MENINGOMYELOCELE. Type I features similar, but less severe malformations and is without an associated meningomyelocele. Type III has the features of type II with an additional herniation of the entire cerebellum through the bony defect involving the foramen magnum, forming an ENCEPHALOCELE. Type IV is a form a cerebellar hypoplasia. Clinical manifestations of types I-III include TORTICOLLIS; opisthotonus; HEADACHE; VERTIGO; VOCAL CORD PARALYSIS; APNEA; NYSTAGMUS, CONGENITAL; swallowing difficulties; and ATAXIA. (From Menkes, Textbook of Child Neurology, 5th ed, p261; Davis, Textbook of Neuropathology, 2nd ed, pp236-46)
Embolization, Therapeutic
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
Nervous System
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Magnetic Resonance Imaging
Magnetic Resonance Angiography
Tomography, X-Ray Computed
Sturge-Weber Syndrome
A non-inherited congenital condition with vascular and neurological abnormalities. It is characterized by facial vascular nevi (PORT-WINE STAIN), and capillary angiomatosis of intracranial membranes (MENINGES; CHOROID). Neurological features include EPILEPSY; cognitive deficits; GLAUCOMA; and visual defects.
Gastrointestinal Hemorrhage
Sclerosing Solutions
Chemical agents injected into blood vessels and lymphatic sinuses to shrink or cause localized THROMBOSIS; FIBROSIS, and obliteration of the vessels. This treatment is applied in a number of conditions such as VARICOSE VEINS; HEMORRHOIDS; GASTRIC VARICES; ESOPHAGEAL VARICES; PEPTIC ULCER HEMORRHAGE.
Cerebral Hemorrhage
Central Nervous System Venous Angioma
A vascular anomaly characterized by a radial or wedge-shaped arrangement of dilated VEINS draining into a larger vein in the brain, spinal cord, or the meninges. Veins in a venous angioma are surrounded by normal nervous tissue, unlike a CENTRAL NERVOUS SYSTEM CAVERNOUS HEMANGIOMA that lacks intervening nervous tissue. Drainage of venous angioma is fully integrated with the body's venous system, therefore, in most cases there is no clinical signs and rare bleeding.
Angiomatosis
Telangiectasis
Central Nervous System Infections
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
Spinal Cord
Dura Mater
Proteus Syndrome
Hamartoneoplastic malformation syndrome of uncertain etiology characterized by partial GIGANTISM of the hands and/or feet, asymmetry of the limbs, plantar hyperplasia, hemangiomas (HEMANGIOMA), lipomas (LIPOMA), lymphangiomas (LYMPHANGIOMA), epidermal NEVI; MACROCEPHALY; cranial HYPEROSTOSIS, and long-bone overgrowth. Joseph Merrick, the so-called "elephant man", apparently suffered from Proteus syndrome and not NEUROFIBROMATOSIS, a disorder with similar characteristics.
Spinal Cord Diseases
Angiography, Digital Subtraction
A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.
Hemangioendothelioma
A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
Nevus, Blue
Usually a benign tumor, that commonly presents as a solitary blue nodule with spindled MELANOCYTES covered by smooth SKIN. Several variants have been identified, one variant being malignant. The blue color is caused by large, densely packed melanocytes deep in the DERMIS of the nevus. In CHILDREN, they usually occur on the BUTTOCKS and LUMBOSACRAL REGION and are referred to as cellular blue nevi. Malignant blue nevi are more commonly found on the SCALP.
Blood Vessels
Cardiac Output, High
A state of elevated cardiac output due to conditions of either increased hemodynamic demand or reduced cardiac oxygen output. These conditions may include ANEMIA; ARTERIOVENOUS FISTULA; THYROTOXICOSIS; PREGNANCY; EXERCISE; FEVER; and ANOXIA. In time, compensatory changes of the heart can lead to pathological form of high cardiac output and eventual HEART FAILURE.
Cyanoacrylates
Cerebral Angiography
Nervous System Malformations
Peripheral Nervous System
The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
Intracranial Hemorrhages
Vascular Headaches
Vascular Neoplasms
Azygos Vein
Pons
Clinically aggressive diffuse capillary telangiectasia of the brain stem: a clinical radiologic-pathologic case study. (1/221)
Capillary malformations or telangiectasias of the brain usually exhibit a benign clinical course, although occassionally they may be associated with mild to moderate symptomatology of uncertain origin. We report a case of an exceptionally aggressive capillary telangiectasia in a child, which was associated with progressive neurologic deterioration resulting in death. (+info)Cerebrovascular manifestations in 321 cases of hereditary hemorrhagic telangiectasia. (2/221)
BACKGROUND AND PURPOSE: Patients with hereditary hemorrhagic telangiectasia (HHT) are at risk for developing cerebral vascular malformations and pulmonary arteriovenous fistulae. We assessed the risk of neurological dysfunction from these malformations and fistulae. METHODS: Three hundred twenty-one consecutive patients with HHT seen at a single institution over a 20-year period were studied. Any evidence of prior neurological symptoms or presence of an intracranial vascular malformation was recorded. All cases of possible cerebral arteriovenous malformation were confirmed by conventional arteriography. RESULTS: Twelve patients (3.7%) had a history of cerebral vascular malformations. Ten patients had arteriovenous malformations, 1 had a dural arteriovenous fistula, and 1 had a cavernous malformation. Seven patients (2.1%) presented with intracranial hemorrhage, 2 presented with seizures alone, and 3 were discovered incidentally. The average age at the time of symptomatic intracranial hemorrhage was 25.4 years. All patients with a history of intracranial hemorrhage were classified as Rankin grade I or II at a mean follow-up interval of 6.0 years. A history of cerebral infarction or transient ischemic attack was found in 29.6% of patients with HHT and a pulmonary arteriovenous fistula. CONCLUSIONS: The risk of intracranial hemorrhage is low among people with HHT. Furthermore, a majority of these patients have a good functional outcome after hemorrhage. The data do not suggest a compelling indication for routine screening of patients with HHT for asymptomatic cerebral vascular malformations. By comparison, pulmonary arteriovenous fistulae are a much more frequent cause of neurological symptoms in this population. (+info)Identification of eight novel 5'-exons in cerebral capillary malformation gene-1 (CCM1) encoding KRIT1. (3/221)
Truncating mutations in the CCM1 gene encoding KRIT1 were recently found in patients affected by inherited cerebral capillary malformations, lesions that cause a wide variety of neurologic problems. However, CCM1 mutations have not been identified in all the families linked to CCM1. Here we demonstrate that the CCM1 gene contains eight additional exons which may thus encompass the missing mutations. (+info)Dural arteriovenous fistula in children: endovascular treatment and outcomes in seven cases. (4/221)
BACKGROUND AND PURPOSE: Dural AVF is a vascular anomaly that rarely occurs in children and is best treated by endovascular embolization. We report our experience using various endovascular embolization techniques in the treatment of dural AVF in a pediatric population. METHODS: Seven children with angiographically proven dural AVF were treated with endovascular embolization using microcoils, N-butylcyanoacrylate, detachable balloons, and/or silk suture. All imaging studies, embolization procedures, and patient charts were retrospectively reviewed. RESULTS: Seven children had been treated for dural AVF at our institution since 1987. Three newborns presented with congestive heart failure. Four older children (10 months-10 years) presented with signs referable to venous hypertension, including seizures, hydrocephalus, and proptosis. Embolization approaches included transarterial, transvenous, and direct puncture after neurosurgical exposure of a dural sinus. The number of embolizations ranged from 1 to 13 sessions per patient. All patients experienced symptomatic improvement after each embolization session. The three newborns showed marked improvement in cardiac function that allowed discharge to home. Clinical follow-up ranged from 3 weeks to 9 years (mean, 4.1 years). Two children with partially embolized dural AVF died, and one was lost to follow-up. Four children are alive after complete embolization of their dural AVF; two are developmentally normal, and two have mild developmental delay. CONCLUSION: Endovascular embolotherapy is the current treatment of choice for dural AVF. Embolization therapy may be life saving in the setting of cardiac failure and curative in cases of small or simple fistulae. Multiple, complex dural AVF are usually not curable, and treatment is aimed at symptomatic relief. Treatment strategies focus on the location and/or complexity of the fistula, the patient's clinical status, and the neurologic prognosis. (+info)Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations. (5/221)
OBJECTIVES: Cerebral cavernous malformations are linked to mutations of the KRIT1 gene at the CCM1 locus and to mutations at two other loci, CCM2 and CCM3, for which genes are not yet identified. There is little information regarding the function of KRIT1. Histological and immunocytochemical analysis of cavernous malformations have not shed much light on their pathophysiology. METHODS: Morphological analysis of cavernous malformations was extended to the ultrastructural level by examining lesions from two patients by immunocytochemistry and electron microscopy. RESULTS: The lesions consisted of endothelial lined vascular sinusoids embedded in a collagen matrix. Nuclei belonging to cells distinct from endothelial cells were rare. The basal lamina of the endothelial cells consisted focally of multiple layers. No tight junctions at endothelial cell interfaces were found; however, several examined endothelial cell interfaces demonstrated apparent gaps between endothelial cell processes where basal lamina was exposed directly to the lumen of the sinusoids. Heavy hemosiderin deposits were found underlying the vascular channels within microns of the basal lamina without evidence of disrupted vessels. No astrocytic foot processes were seen within lesions. Glial fibrillary acidic protein immunocytochemistry confirmed that astrocyte processes stopped at the border of the lesions. CONCLUSIONS: The absence of blood-brain barrier components may lead to leakage of red blood cells into these lesions and the surrounding brain in the absence of major haemorrhage, thus accounting for the propensity of cavernous malformations to cause seizures. These data also raise the possibility that KRIT1 plays a part in the formation of endothelial cell junctions and expression of a mature vascular phenotype. (+info)MR imaging and histologic features of capillary telangiectasia of the basal ganglia. (6/221)
Capillary telangiectasias are being recognized with increasing frequency on MR imaging studies. Most are located in the brain stem and show slightly increased signal intensity on T2-weighted images, low signal intensity on T2*-weighted images (reflecting the presence of deoxyhemoglobin), and contrast enhancement. These findings are considered fairly typical for capillary telangiectasia, and pathologic correlation is not generally pursued. We present a case of a proven capillary telangiectasia in the basal ganglia. The imaging features of the lesion were identical to those described for capillary telangiectasias in the brain stem. (+info)Spinal dural arteriovenous fistulae--a diagnostic challenge. (7/221)
BACKGROUND: Spinal dural arteriovenous fistulae comprise the majority of spinal vascular malformations. The most common clinical presentation is that of progressive myeloradiculopathy, probably related to venous hypertension, which may lead to permanent disability and even death. OBJECTIVE: To report our clinical experience with spinal dural arteriovenous fistulae. METHODS: Nine patients with spinal dural AVF were managed at our center during a one year period (1998-1999). The patients, eight men and one woman ranging in age from 46 to 75 years, presented with initially fluctuating and eventually permanent and progressive paraparesis, sensory disturbances and sphincter dysfunction. The neurological signs generally began symmetrically and progressed from the distal to proximal limb regions. The duration of symptoms before diagnosis ranged from 6 to 36 months during which the patients underwent an extensive but fruitless work-up and even unnecessary operations due to misdiagnosis. All patients finally underwent magnetic resonance imaging and spinal angiography, which demonstrated the pathological vascular fistula. Interruption of the AVF was achieved by embolization or by surgical resection. RESULTS: Following treatment, six patients experienced improvement of gait and sphincter control, and the severe neurological deficits stabilized in the other three patients with long duration of illness. There was no further deterioration in any of the treated patients. CONCLUSIONS: The history, neurological findings and radiological changes on MRI scan should alert clinicians to the possibility of spinal dural AVF, leading to diagnostic spinal angiography. Early diagnosis and treatment may significantly improve outcome and prevent permanent disability and even mortality. (+info)Dural arteriovenous fistulae: noninvasive diagnosis with dynamic MR digital subtraction angiography. (8/221)
MR digital subtraction angiography (DSA) is a new diagnostic tool capable of producing dynamic images of the cerebral circulation with the injection of gadopentetate dimeglumine into a peripheral vein. Previous reports have concentrated on its potential as a noninvasive technique for the study of pial arteriovenous malformations. In this report, we present our early findings with MR DSA in the evaluation of intracranial dural arteriovenous fistulae. (+info)
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Superior cistern
Pediatric Central Nervous System Vascular Malformations". Stroke in Children and Young Adults (2nd ed.). Saunders. pp. 315-326 ... Arteriovenous malformations of the great cerebral vein can create an enlarged pouch of vein in the superior cistern. This is ...
Central nervous system cavernous hemangioma
Recently it has been shown that the deletion of CDC42 in endothelial cells elicits cerebral vascular malformations, suggesting ... Cerebral cavernous malformation (CCM) is a cavernous hemangioma that arises in the central nervous system (CNS). It can be ... In 2015 it was reported that the endothelial cells forming cerebral vascular malformations undergo an endothelial to ... Castro, Marco (2019). "CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression". ...
Arteriovenous malformation
"Arteriovenous Malformations and Other Vascular Lesions of the Central Nervous System Fact Sheet , National Institute of ... bypassing the capillary system. This vascular anomaly is widely known because of its occurrence in the central nervous system ( ... Arteries and veins are part of the vascular system. Arteries carry blood away from the heart to the lungs or the rest of the ... Normally, the arteries in the vascular system carry oxygen-rich blood, except in the case of the pulmonary artery. Structurally ...
WHO classification of tumours of the central nervous system
... myofibroblastic tumours 7.1.1.1 Solitary fibrous tumour 7.1.2 Vascular tumours 7.1.2.1 Hemangiomas and vascular malformations ... Grading of the tumors of the central nervous system See the article Grading of the tumors of the central nervous system. Louis ... The following is a simplified (deprecated) version of the 2021 WHO classification of the tumours of the central nervous system ... 2016). WHO Classification of Tumours of the Central Nervous System (Revised 4th ed.). Lyon: International Agency for Research ...
List of MeSH codes (C16)
... central nervous system vascular malformations MeSH C16.131.666.190.200 - hemangioma, cavernous, central nervous system MeSH ... intracranial arteriovenous malformations MeSH C16.131.240.275 - central nervous system vascular malformations MeSH C16.131. ... central nervous system venous angioma MeSH C16.131.666.190.800 - sinus pericranii MeSH C16.131.666.205 - Dandy-Walker syndrome ... hereditary central nervous system demyelinating diseases MeSH C16.320.400.400 - hereditary motor and sensory neuropathies MeSH ...
List of MeSH codes (C14)
... vascular headaches MeSH C14.907.253.946 - vasculitis, central nervous system MeSH C14.907.253.946.175 - aids arteritis, central ... intracranial arteriovenous malformations MeSH C14.907.184.140 - aids arteritis, central nervous system MeSH C14.907.184.281 - ... central nervous system MeSH C14.907.940.907.175 - aids arteritis, central nervous system MeSH C14.907.940.907.350 - lupus ... nervous system MeSH C14.907.253.946.350 - lupus vasculitis, central nervous system MeSH C14.907.253.946.700 - temporal ...
Diabetes
... congenital heart and central nervous system abnormalities, and skeletal muscle malformations. Increased levels of insulin in a ... In severe cases, perinatal death may occur, most commonly as a result of poor placental perfusion due to vascular impairment. ... In countries using a general practitioner system, such as the United Kingdom, care may take place mainly outside hospitals, ... March 2016). "Cardiovascular and Renal Outcomes of Renin-Angiotensin System Blockade in Adult Patients with Diabetes Mellitus: ...
International Classification of Headache Disorders
Headache attributed to primary central nervous system (CNS) angiitis Headache attributed to secondary central nervous system ( ... to unruptured vascular malformation Headache attributed to saccular aneurysm Headache attributed to arteriovenous malformation ... Headache attributed to benign angiopathy of the central nervous system Headache attributed to pituitary apoplexy Headache ... neuralgia Tolosa-Hunt syndrome Opthalamoplegic migraine Central causes of facial pain Anaesthesia dolorosa Central post-stroke ...
Bonnet-Dechaume-Blanc syndrome
Central nervous system (CNS) symptoms of Bonnet-Dechaume-Blanc syndrome are highly dependent on the locations and sizes of ... Notably, the patient did not have retinal vascular malformations. Lesions are watched closely for changes in size. Prognosis is ... Bonnet-Dechaume-Blanc syndrome usually presents itself with a combination of central nervous system features (midbrain), ... Since the retinal lesions categorized vary from large vascular malformations that affect a majority of the retina to ...
Adams-Oliver syndrome
McGoey RR, Lacassie Y (2008). "Adams-Oliver syndrome in siblings with central nervous system findings, epilepsy, and ... Other vascular abnormalities described in AOS include absent portal vein, portal sclerosis, arteriovenous malformations, ... Syndromes affecting the nervous system, Genetic disorders with OMIM but no gene, Syndromes affecting the skin). ... including cardiovascular malformations, cleft lip and/or palate, abnormal renal system, and neurologic disorders manifesting as ...
List of diseases (S)
... dysplasia Spondyloperipheral dysplasia short ulna Spongiform encephalopathy Spongy degeneration of central nervous system ... to immotile flagella Stern-Lubinsky-Durrie syndrome Sternal cleft Sternal cyst vascular anomalies Sternal malformation vascular ... Simosa-Penchaszadeh-Bustos syndrome Simpson-Golabi-Behmel syndrome Singh-Chhaparwal-Dhanda syndrome Single upper central ... fusion limb defects micrognatia Splenomegaly Split hand deformity mandibulofacial dysostosis Split hand split foot malformation ...
Hereditary neurocutaneous angioma
The Newborn with Central Nervous System Involvement". American Journal of Diseases of Children. 108: 418-424. doi:10.1001/ ... Family history examination found vascular malformations of the skin in 6 other members belonging to 3 generations of his family ... those which are present in the central nervous system tend to bleed more easily and often. These lesions typically vary in size ... and familial vascular malformation: Case report". Neurology. 30 (3): 308-311. doi:10.1212/WNL.30.3.308. ISSN 0028-3878. PMID ...
Vascular tumor
Hemangioblastomas are vascular tumors of the central nervous system. A range of benign vascular tumors are described as ... Vascular tumors make up one of the classifications of vascular anomalies. The other grouping is vascular malformations. ... Vascular tumors are described as proliferative, and vascular malformations as nonproliferative. A vascular tumor typically ... A vascular tumor is a tumor of vascular origin; a soft tissue growth that can be either benign or malignant, formed from blood ...
Headache
... headache evaluation may include CT scan or MRI in order to look for possible structural disorders of the central nervous system ... vascular malformations or arteritis are also defined as secondary headaches. This type of headache may also be caused by ... According to this system, there are 19 types of neuralgias and headaches due to different central causes of facial pain. ... of disorders or diseases that are intracranial but that are not associated with the vasculature of the central nervous system.[ ...
Neurosurgery
This includes the central nervous system and the peripheral nervous system. Tissue analysis comes from either surgical biopsies ... Saleem Abdulrauf - developed "awake" craniotomy for complex aneurysms and vascular malformations. John R. Adler - Stanford ... Conditions treated by neurosurgeons include, but are not limited to: Meningitis and other central nervous system infections ... treatment of benign and malignant central and peripheral nervous system cancers and pre-cancerous lesions in adults and ...
Anand Veeravagu
Tumors of the Central Nervous System by M.A. Hayat "Anand Veeravagu- Dura: Resources for Neurosurgery Residents - Stanford ... Veeravagu's surgical interests include brain tumors, vascular malformations, and severe spine deformities. Glioblastoma ... Radiosurgery in the Management of Central Nervous System Disease Editors Kleinberg, Rigamonti, Hsu, and Lim. ...
Wouter Schievink
... and collagen vascular disease as related to the central nervous system. Schievink is also an expert and well published author ... net/news/20100504/New-study-shows-people-with-BAV-more-likely-to-have-brain-aneurysms.aspx Arteriovenous Malformation (AVM) ... Wouter Ingmar Schievink (born 1963, Amsterdam) is a neurological surgeon noted for expertise in brain and spinal cord vascular ...
Interventional neuroradiology
... in order to identify central nervous system diseases such as tumors or arteriovenous malformations. He performed the first ... Juvenile nasopharyngeal tumor Meningiomas Nosebleeds Paragangliomas Stroke Spinal vascular malformations Traumatic vascular ... and paraspinal vascular malformations Head and neck tumors Intracranial atherosclerosis ... These two stages, at the basis of modern invasive vascular diagnostics, prepared the way for later therapeutic developments. ...
Epilepsy
A lumbar puncture may be useful to diagnose a central nervous system infection but is not routinely needed. In children ... The mutation results in vascular malformations affecting the brain, skin and eyes. The typical presentation includes a facial ... are a group of multisystemic diseases that most prominently affect the skin and central nervous system. They are caused by ... previous infections of the central nervous system, genetic abnormalities, and as a result of brain damage around the time of ...
Amyoplasia
Additionally, malformations may occur in the central nervous system and/or spinal cord that can lead to a lack of fetal ... of children with amyoplasia have evidence of vascular compromise including Intestinal atresia, abdominal wall defects, and ...
Magnetic resonance imaging
The contrast provided between grey and white matter makes MRI the best choice for many conditions of the central nervous system ... vascular diseases, and congenital heart disease. Applications in the musculoskeletal system include spinal imaging, assessment ... arteriovenous malformations, and other surgically treatable conditions using a device known as the N-localizer. New tools that ... The field strength of the magnet is measured in teslas - and while the majority of systems operate at 1.5 T, commercial systems ...
Chronic cerebrospinal venous insufficiency controversy
A chronic state of impaired venous drainage from the central nervous system, termed chronic cerebrospinal venous insufficiency ... A vascular component in MS had been cited previously. Several characteristics of venous diseases make it difficult to include ... Most of the venous problems in MS patients have been reported to be truncular venous malformations, including azygous stenosis ... Italian researcher Paolo Zamboni in 2008 to describe compromised flow of blood in the veins draining the central nervous system ...
Burton Drayer
MRI Contrast Enhancement in the Central Nervous System. A Case Approach. (Assoc. Eds., Drayer BP, Haughton VM, Jinkins JR, ... vascular malformation advanced CT and MRI techniques for the diagnosis of brain neoplasm. He is known for brain iron, ... As of 2020, he is the Charles M. and Marilyn Newman Professor and System Chair, Radiology, for The Mount Sinai Health System ... "Burton P Drayer MD". Mount Sinai Health System. Retrieved 20 May 2020. Mount Sinai Health System Profile Icahn School of ...
Epileptic spasms
... the epilepsy is the consequence of a known or suspected disorder of the central nervous system. cryptogenic: this refers to a ... Aicardi syndrome cephalhematoma and vascular malformation. Furthermore, other causes increasingly being named in the literature ... Mol Syndromol 2(3-5):137-152 Sherr EH (2003) The ARX story (epilepsy, mental retardation, autism, and cerebral malformations): ...
Radiation therapy
... late effect neuropathy may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS). In the CNS ... Radiation-induced fibrosis, vascular cell damage and oxidative stress can lead to these and other late side effect symptoms. ... there appears to be no increase in genetic defects or congenital malformations in their children conceived after therapy. ... Atrophy, fibrosis and vascular changes produce malabsorption, diarrhea, steatorrhea and bleeding with bile acid diarrhea and ...
Pediatric plastic surgery
Craniosynostosis is a congenital abnormality originating from the central nervous system in which one or more of the fibrous ... Vascular anomalies - vascular malformations, hemangiomas, and rare vascular tumors. Not only do vascular anomalies have often ... Specialists involve in vascular anomalies and hemangioma care often hail from the disciplines of general surgery, vascular ... The child needs treatment not only to minimize the physical side effects of a hemangioma or vascular anomalies, but also help ...
Edoxaban
... for the prevention of stroke and non-central-nervous-system systemic embolism. It was approved for use in the European Union in ... arteriovenous malformations, aneurysms or major intraspinal or intracerebral vascular abnormalities who have uncontrolled and ...
Ephrin
During the development of the central nervous system Eph/ephrin signaling plays a critical role in the cell-cell mediated ... this ephrin does not contribute to vascular deformities during development. Moreover, Ephrin-B2 and EphB4 may also contribute ... "Ephrin B2 and EphB4 selectively mark arterial and venous vessels in cerebral arteriovenous malformation". The Journal of ... Mann F, Ray S, Harris W, Holt C (Aug 2002). "Topographic mapping in dorsoventral axis of the Xenopus retinotectal system ...
Transverse myelitis
... lesions in acute TM are mostly limited to the spinal cord with no involvement of other structures in the central nervous system ... Other associated causes include the helminth infection schistosomiasis, spinal cord injuries, vascular disorders that impede ... of the anterior spinal artery Evidence of extra-axial compression on neuroimaging Evidence of arteriovenous malformation ( ... Disturbances in sensory nerves and motor nerves and dysfunction of the autonomic nervous system at the level of the lesion or ...
Paresthesia
An MRI or a CT scan is sometimes used to rule out certain causes stemming from central nervous system issues.[citation needed] ... Belch JJ, McCollum PT, Walker WF, Stonebridge PA (1996). Color atlas of peripheral vascular diseases. Mosby-Wolfe. p. 77. ISBN ... Carpal tunnel syndrome Cerebral amyloid angiopathy Chiari malformation Coeliac disease (celiac disease) Complex regional pain ... may experience paresthesia from damage to the central nervous system.[citation needed] The varicella zoster virus disease ( ...
Primary effusion lymphoma
... central nervous system symptoms), or breast implants (e.g. breast swelling/pain/malformation). While most cases of classical ... overexpression of the P-selectin glycoprotein ligand-1 gene whose protein product promotes cell attachment to vascular ... Individuals with extracavitary PEL present with lesions in the lung, central nervous system, gastrointestinal tract, and/or ... central nervous system, testes, paranasal sinuses, muscle, and, rarely, inside the vasculature and sinuses of lymph nodes. As ...
Craniopagus twins
... which is responsible for the ultimate fusion and formation of the brain stem and central nervous system. Furthermore, this ... He describes the set of twins as being a unique malformation and a punishment from their mother's mistake. In French barber ... Technologies such as CT scans, MRIs, and angiography are used to map the shared vascular structures. Emilie and Elisabeth Stoll ... In 2006, Stone and Goodrich came up with a more nuanced classification system, which is the "most commonly used" system. ...
Spinal cord injury
... the peripheral nervous system has a greater capacity for healing than the central nervous system. Signs (observed by a ... Damage can result from dysfunction of the blood vessels, as in arteriovenous malformation, or when a blood clot becomes lodged ... SCI may occur in intervertebral disc disease, and spinal cord vascular disease. Spontaneous bleeding can occur within or ... "Toward Functional Restoration of the Central Nervous System: A Review of Translational Neuroscience Principles". Neurosurgery. ...
T2*-weighted imaging
"Superficial Siderosis of the Central Nervous System Induced by a Single-Episode of Traumatic Subarachnoid Hemorrhage: A Study ... Diseases with such patterns include intracranial hemorrhage, arteriovenous malformation, cavernoma, hemorrhage in a tumor, ... punctate hemorrhages in diffuse axonal injury, superficial siderosis, thrombosed aneurysm, phleboliths in vascular lesions, and ... In an idealized system, all nuclei in a given chemical environment, in a magnetic field, relax with the same frequency. However ...
List of skin conditions
Neurocutaneous conditions are due organic nervous system disease or are psychiatric in etiology. Atypical chronic pain syndrome ... Thyroglossal duct cyst Verrucous vascular malformation (angiokeratoma circumscriptum naeviforme) Connective tissue diseases are ... Bubble hair deformity Central centrifugal cicatricial alopecia (follicular degeneration syndrome, pseudopelade of the central ... Many skin conditions affect the human integumentary system-the organ system covering the entire surface of the body and ...
Blue rubber bleb nevus syndrome
The lesions can also be found in the central nervous system, liver, and muscles. It usually presents soon after birth or during ... Capillary malformations, hyperkeratotic stains, telangiectasias, and miscellaneous vascular blots". In Mulliken, John B.; ... Burrows, Patricia E.; Fishman, Steven J. (eds.). Mulliken and Young's Vascular Anomalies: Hemangiomas and Malformations (2nd ed ... Bean WB (1958). Vascular spiders and related lesions of the skin. Springfield, Illinois: Charles C.Thomas. pp. 178-85. Blue ...
Ollier disease
... carries a higher risk of malignancies such as central nervous system (CNS), ovarian, and adenocarcinoma. Cranial ... "R132C IDH1 Mutations Are Found in Spindle Cell Hemangiomas and Not in Other Vascular Tumors or Malformations". The American ... Van Loon, Pieter; Lammens, Johan (March 2008). "Malformation of the humerus in a patient with Ollier disease treated with the ... Both the elastic stable intramedullary nailing system (ESIN) and flexible intramedullary nailing (FIN) use two bent elastic ...
NMDA receptor
... s are a crucial part of the development of the central nervous system. The processes of learning, memory, and ... an alternative pharmacological therapeutic principle in Alzheimer's and vascular dementia". Current Pharmaceutical Design. 10 ( ... of excitotoxicity in disease includes gain-of-function mutations in GRIN2B and GRIN1 associated with cortical malformations, ... Parsons MP, Raymond LA (April 2014). "Extrasynaptic NMDA receptor involvement in central nervous system disorders". Neuron. 82 ...
Interventional radiology
... root is the initial or proximal segment of one of the thirty-one pairs of spinal nerves leaving the central nervous system from ... Catheter placement Central venous catheter placement: Vascular access and management of intravenous devices (IVs), including ... Arteriovenous malformations (AVMs) are abnormal blood vessel structures in which an artery connects to a vein via an abnormal ... Vascular and Interventional Radiologists are at the forefront of treating a wide variety of vascular diseases. Since its ...
Effects of long-term benzodiazepine use
Kellogg CK (1985). "Drugs and chemicals that act on the central nervous system: interpretation of experimental evidence". ... The best available evidence suggests that benzodiazepines are not a major cause of birth defects, i.e. major malformations or ... The Epidemiology of Vascular Aging Study". Journal of Clinical Psychopharmacology. 22 (3): 285-293. doi:10.1097/00004714- ... The prenatal toxicity of benzodiazepines is most likely due to their effects on neurotransmitter systems, cell membranes and ...
Programmed cell death
It has been observed before and during synaptogenesis in the central nervous system as well as the peripheral nervous system. ... Martin Bonke and his colleagues had stated that one of the two long-distance transport systems in vascular plants, xylem, ... The absence or reduction of PCD can cause serious anatomical malformations but can also result in minimal consequences ... Different mechanisms regulate PCD in the peripheral nervous system (PNS) versus the central nervous system (CNS). In the PNS, ...
Chemotherapy
Agarwala SS, Kirkwood JM (2000). "Temozolomide, a novel alkylating agent with activity in the central nervous system, may ... There are many intravenous methods of drug delivery, known as vascular access devices. These include the winged infusion device ... In females previously having undergone chemotherapy, miscarriage and congenital malformations are not increased in subsequent ... If the cancer has central nervous system involvement, or with meningeal disease, intrathecal chemotherapy may be administered. ...
Small supernumerary marker chromosome
... malformations of the limbs and skeleton; and/or abnormalities of the central nervous system, heart, and/or genitourinary tract ... genitourinary and various vascular and cardiac anomalies. The syndrome is caused by an sSMC bearing two copies (that are ... sSMC's occur in ring or centric minute (linear with a central centromere) shapes, may contain inverted repeats of its genetic ... Low grade osteosarcomas (LGO), including low grade central and parosteal osteosarcomas, are far less malignant than most other ...
List of syndromes
... worship syndrome Central centrifugal cicatricial alopecia Central cord syndrome Central nervous system syndrome Central pain ... syndrome Van der Woude syndrome van Gogh syndrome Van Wyk and Grumbach syndrome Vanishing bile duct syndrome Vascular access ... Lynch syndrome Lyngstadaas syndrome Löffler's syndrome Löfgren syndrome M74 syndrome Macrocephaly-capillary malformation ...
Birth defect
If exposed to rubella in the second trimester, the fetus can develop central nervous system malformations. However, because ... vascular disruption, and specific receptor- or enzyme-mediated teratogenesis. An estimated 10% of all birth defects are caused ... Other congenital anomalies of the nervous system include the Arnold-Chiari malformation, the Dandy-Walker malformation, ... Gaitanis, John; Tarui, Tomo (2018). "Nervous System Malformations". CONTINUUM: Lifelong Learning in Neurology. 24 (1): 72-95. ...
Syringomyelia
Recent work suggests that central nervous system compliance is the underlying problem for the central nervous system, and also ... The first major form relates to an abnormality of the brain called an Arnold-Chiari malformation or Chiari malformation. This ... Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists, Adelaide (AU): University of Adelaide Press, ISBN ... A syrinx may also cause disruptions in the parasympathetic and sympathetic nervous systems, leading to abnormal body ...
Caffeine
... is a central nervous system (CNS) stimulant of the methylxanthine class. It is used as a cognitive enhancer, ... Secondly, around the vascular bundles, where it probably inhibits pathogenic fungi from entering and colonizing the vascular ... A 2011 review found that caffeine during pregnancy does not appear to increase the risk of congenital malformations, ... Caffeine is a central nervous system stimulant that may reduce fatigue and drowsiness. At normal doses, caffeine has variable ...
CT scan
Ramalho, Joana; Castillo, Mauricio (2014-03-31). Vascular Imaging of the Central Nervous System: Physical Principles, Clinical ... arteriovenous malformations, and other surgically treatable conditions using a device known as the N-localizer. Contrast CT is ... Dual source CT is an advanced scanner with a two X-ray tube detector system, unlike conventional single tube systems. These two ... "Mitigating motion artifacts in FDK based 3D Cone-beam Brain Imaging System using markers". Central European Journal of ...
Fetal warfarin syndrome
... has also been observed Defects of the central nervous system can lead to profound intellectual disabilities. Fetal warfarin ... Danziger, J. 2008, "Vitamin K-dependent Proteins, Warfarin, and Vascular Calcification", Clinical Journal of the American ... malformation of joints. Abnormalities of the chest: either pectus carinatum; a protruding sternum, or pectus excavatum; a ... while warfarin taken in the second and third trimester more commonly causes abnormalities of the central nervous system. The ...
GDF11
It may also help regulate development of the central nervous system, blood vessels, the kidney and other tissues. GDF11 ... May 2014). "Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors". Science. 344 (6184): 630- ... June 2008). "VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase ... GDF11 is expressed in many tissues, including skeletal muscle, pancreas, kidney, nervous system, and retina. Gene deletion and ...
Vitamin A
Symptoms may include nervous system effects, liver abnormalities, fatigue, muscle weakness, bone and skin changes and others. ... "Rank order of vitamin A content in foods, retinol activity equivalent (RAE) in ug per 100 g". FoodData Central, US Department ... Pawlikowski B, Wragge J, Siegenthaler JA (July 2019). "Retinoic acid signaling in vascular development". Genesis. 57 (7-8): ... cardiovascular and neurological malformations or thymic disorders. Neurocognitive impairments in the absence of any physical ...
STK24
CCM is a pathological vascular situation that, influencing the blood vessels in central nervous system (CNS), may cause stroke ... network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. ...
Expression of angiogenic growth factor in the rat DAVF model
MESH TREE NUMBER CHANGES - 2008 MeSH
Central Nervous System Vascular Malformations. C14.240.275 C14.240.850.875. C16.131.240.275 C16.131.240.850.875. Central ... Lupus Vasculitis, Central Nervous System. C10.114.875.350 C10.114.875.850. C10.228.140.300.850.250 C10.228.140.300.850.750. ... Hemangioma, Cavernous, Central Nervous System. C14.907.934.385.500 C14.240.850.875.249. C14.907.454.385.500. Hematocrit G9.188. ... Hereditary Central Nervous System Demyelinating Diseases. C16.320.400.393 C16.320.400.367. Herpes Simplex Virus Protein Vmw65 ...
Complex Partial Seizures: Practice Essentials, Background, Pathophysiology
Vascular malformations. * Stroke. * Central nervous system (CNS) infections. * Immune-mediated CNS inflammation ... In utero antiepileptic drug exposure: fetal death and malformations. Neurology. 2006 Aug 8. 67(3):407-12. [QxMD MEDLINE Link]. ... A complex partial seizure, now known as a focal impaired awareness seizure according to the updated classification system from ... In 2017, the ILAE updated its seizure classification system and complex partial seizures are now known as focal impaired ...
Brain AVM (arteriovenous malformation) - Symptoms and causes - Mayo Clinic
Arteriovenous malformations and other vascular lesions of the central nervous system fact sheet. National Institute of ... Cerebral vascular malformations. Mayo Clinic; 2021.. *Ferri FF. AV malformations, cerebral. In: Ferris Clinical Advisor 2022. ... A three-dimensional color-printed system allowing complete modeling of arteriovenous malformations for surgical simulations. ... A brain arteriovenous malformation may not cause any signs or symptoms until the AVM ruptures, resulting in hemorrhage. In ...
Conditions - Arteriouvenous Malformation | Medtronic
Learn more about arteriouvenous malformation and potential treatment options for this condition. ... Arteriovenous malformations and other vascular lesions of the central nervous system fact sheet. Available at: https://www. ... An arteriovenous malformation, AVM, is an abnormal connection between arteries and veins. It involves a defect in the blood ... However, in an AVM, such a capillary system is absent, and blood gets shunted from the arteries directly to the veins.2 ...
Postoperative hyperperfusion in a patient with a dural arteriovenous fistula with retrograde leptomeningeal venous drainage:...
Pediatric intramedullary spinal cavernous malformations.<...
SUMMARY OF BACKGROUND DATA: Cavernous malformations can occur throughout the central nervous system; however, the ... More recent estimates indicate that cavernous malformations constitute 5% of all vascular malformations. There is no series ... SUMMARY OF BACKGROUND DATA: Cavernous malformations can occur throughout the central nervous system; however, the ... SUMMARY OF BACKGROUND DATA: Cavernous malformations can occur throughout the central nervous system; however, the ...
JPS | 124-10e
Both cases exhibited central nervous system symptoms such as convulsions and disturbance of consciousness within approximately ... Streptococcal Toxic Shock Syndrome Arising from a Site of Intramuscular Vascular Malformation: Two Case Reports ... Streptococcal Toxic Shock Syndrome Arising from a Site of Intramuscular Vascular Malformation: Two Case Reports Author. Akiko ... Here, we present the cases of two children with congenital intramuscular vascular malformations who developed swelling and pain ...
Gamma Knife surgery for clival epidural-osseous dural arteriovenous fistulas - 指紋 - 臺北醫學大學
Radiology - Research output - Mayo Clinic
Central Nervous System Vascular Malformations 100% * Angiography 58% * Magnetic Resonance Imaging 48% ... Volumetric flow rates in the portal venous system: Measurement with cine phase-contrast MR imaging. Burkart, D. J., Johnson, C ... Volume-staged stereotactic radiosurgery for intracranial arteriovenous malformations: Outcomes based on an 18-year experience. ...
The Lehigh Valley Region's First Pediatric Neurosurgeon Joins LVHN
Treating central nervous system and spine conditions. Dr. Hong treats a wide variety of brain, skull, spinal cord and spinal ... Intracranial vascular malformations. *Moyamoya syndrome. *Neurofibromatosis tumors. *Scoliosis and other spinal deformities ... LVHN First in Pennsylvania to Use SeaSpines FLASH™ Navigation System With 7D Technology May 25, 2022 ...
Michael Zhang's Profile | Stanford Profiles
Intramedullary spinal cord cavernous malformations (CMs) account for 5% of all CMs in the central nervous system and 5% to 12% ... Contralateral acute vascular occlusion following revascularization surgery for moyamoya disease JOURNAL OF NEUROSURGERY Sussman ... Milestones in stereotactic radiosurgery for the central nervous system. Journal of clinical neuroscience : official journal of ... Milestones in stereotactic radiosurgery for the central nervous system JOURNAL OF CLINICAL NEUROSCIENCE Mitrasinovic, S., Zhang ...
Genetics of epilepsy - Information - 2022
Pediatric Central Nervous System Vascular Malformations. Cavernous Malformations. Pathology. A cavernous malformation is a ... 63 A cavernous malformation appears as a well-defined, lobulated lesion with a central core of reticulated mixed signal ... The MRI appearance of cavernous malformations is the most sensitive diagnostic test for cavernous malformations, and it is ... The natural history of the cavernous malformation is still being elucidated. Cavernous malformations are dynamic lesions that ...
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Division of Pulmonary & Critical Care Medicine - Research output
- Research Profiles at Washington University School of...
Vascular Malformations 36% * Mortality 35% * Central Nervous System Vascular Malformations 24% * Anemia 15% ... the Brain Vascular Malformation Consortium HHT Investigator Group, Dec 2021, In: Orphanet Journal of Rare Diseases. 16, 1, 12. ... The Clinical Course of Coronavirus Disease 2019 in a US Hospital System: A Multistate Analysis. Mody, A., Lyons, P. G., Vazquez ... Point-of-care Ultrasound-guided Central Venous Catheter Confirmation in Ultrasound Nonexperts. Ablordeppey, E. A., Drewry, A. M ...
Dural Arteriovenous Fistula Presenting as Trigeminal Neuralgia: 2 Case Reports and Review of the Literature - Fingerprint
...
Immunothrombosis and vascular heterogeneity in cerebral cavernous malformation | Blood | American Society of Hematology
Cavernomas have stable clots with polyhedrocytes that result in cerebral hypoxia.CCM lesions have a vascular heterogeneity with ... Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral ... VASCULAR BIOLOGY, November 17, 2022 Immunothrombosis and vascular heterogeneity in cerebral cavernous malformation Maria A. ... Cerebral cavernous malformation (CCM) is a vascular disease that is characterized by mulberry-like lesions in the brain and ...
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MESH TREE NUMBER CHANGES - 2008 MeSH
Central Nervous System Vascular Malformations. C14.240.275 C14.240.850.875. C16.131.240.275 C16.131.240.850.875. Central ... Lupus Vasculitis, Central Nervous System. C10.114.875.350 C10.114.875.850. C10.228.140.300.850.250 C10.228.140.300.850.750. ... Hemangioma, Cavernous, Central Nervous System. C14.907.934.385.500 C14.240.850.875.249. C14.907.454.385.500. Hematocrit G9.188. ... Hereditary Central Nervous System Demyelinating Diseases. C16.320.400.393 C16.320.400.367. Herpes Simplex Virus Protein Vmw65 ...
MESH TREE NUMBER CHANGES - 2008 MeSH
Central Nervous System Vascular Malformations. C14.240.275 C14.240.850.875. C16.131.240.275 C16.131.240.850.875. Central ... Lupus Vasculitis, Central Nervous System. C10.114.875.350 C10.114.875.850. C10.228.140.300.850.250 C10.228.140.300.850.750. ... Hemangioma, Cavernous, Central Nervous System. C14.907.934.385.500 C14.240.850.875.249. C14.907.454.385.500. Hematocrit G9.188. ... Hereditary Central Nervous System Demyelinating Diseases. C16.320.400.393 C16.320.400.367. Herpes Simplex Virus Protein Vmw65 ...
DeCS
Vascular Malformation, CNS Vascular Malformations, CNS Vascular Malformations, Central Nervous System Central Nervous System ... Vascular Malformations, CNS. Vascular Malformations, Central Nervous System. Vascular Malformations, Congenital, Nervous System ... Central Nervous System Vascular Malformations Entry term(s). CNS Vascular Malformation CNS Vascular Malformations Central ... Vascular Anomalies, Central Nervous System. Vascular Malformation, Brain. Vascular Malformation, CNS. Vascular Malformations, ...
MESH TREE NUMBER CHANGES - 2008 MeSH
Central Nervous System Vascular Malformations. C14.240.275 C14.240.850.875. C16.131.240.275 C16.131.240.850.875. Central ... Lupus Vasculitis, Central Nervous System. C10.114.875.350 C10.114.875.850. C10.228.140.300.850.250 C10.228.140.300.850.750. ... Hemangioma, Cavernous, Central Nervous System. C14.907.934.385.500 C14.240.850.875.249. C14.907.454.385.500. Hematocrit G9.188. ... Hereditary Central Nervous System Demyelinating Diseases. C16.320.400.393 C16.320.400.367. Herpes Simplex Virus Protein Vmw65 ...
MESH TREE NUMBER CHANGES - 2008 MeSH
Central Nervous System Vascular Malformations. C14.240.275 C14.240.850.875. C16.131.240.275 C16.131.240.850.875. Central ... Lupus Vasculitis, Central Nervous System. C10.114.875.350 C10.114.875.850. C10.228.140.300.850.250 C10.228.140.300.850.750. ... Hemangioma, Cavernous, Central Nervous System. C14.907.934.385.500 C14.240.850.875.249. C14.907.454.385.500. Hematocrit G9.188. ... Hereditary Central Nervous System Demyelinating Diseases. C16.320.400.393 C16.320.400.367. Herpes Simplex Virus Protein Vmw65 ...
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MESH TREE NUMBER CHANGES - 2008 MeSH
Central Nervous System Vascular Malformations. C14.240.275 C14.240.850.875. C16.131.240.275 C16.131.240.850.875. Central ... Lupus Vasculitis, Central Nervous System. C10.114.875.350 C10.114.875.850. C10.228.140.300.850.250 C10.228.140.300.850.750. ... Hemangioma, Cavernous, Central Nervous System. C14.907.934.385.500 C14.240.850.875.249. C14.907.454.385.500. Hematocrit G9.188. ... Hereditary Central Nervous System Demyelinating Diseases. C16.320.400.393 C16.320.400.367. Herpes Simplex Virus Protein Vmw65 ...
MESH TREE NUMBER CHANGES - 2008 MeSH
Central Nervous System Vascular Malformations. C14.240.275 C14.240.850.875. C16.131.240.275 C16.131.240.850.875. Central ... Lupus Vasculitis, Central Nervous System. C10.114.875.350 C10.114.875.850. C10.228.140.300.850.250 C10.228.140.300.850.750. ... Hemangioma, Cavernous, Central Nervous System. C14.907.934.385.500 C14.240.850.875.249. C14.907.454.385.500. Hematocrit G9.188. ... Hereditary Central Nervous System Demyelinating Diseases. C16.320.400.393 C16.320.400.367. Herpes Simplex Virus Protein Vmw65 ...
MESH TREE NUMBER CHANGES - 2008 MeSH
Central Nervous System Vascular Malformations. C14.240.275 C14.240.850.875. C16.131.240.275 C16.131.240.850.875. Central ... Lupus Vasculitis, Central Nervous System. C10.114.875.350 C10.114.875.850. C10.228.140.300.850.250 C10.228.140.300.850.750. ... Hemangioma, Cavernous, Central Nervous System. C14.907.934.385.500 C14.240.850.875.249. C14.907.454.385.500. Hematocrit G9.188. ... Hereditary Central Nervous System Demyelinating Diseases. C16.320.400.393 C16.320.400.367. Herpes Simplex Virus Protein Vmw65 ...
MESH TREE NUMBER CHANGES - 2008 MeSH
Central Nervous System Vascular Malformations. C14.240.275 C14.240.850.875. C16.131.240.275 C16.131.240.850.875. Central ... Lupus Vasculitis, Central Nervous System. C10.114.875.350 C10.114.875.850. C10.228.140.300.850.250 C10.228.140.300.850.750. ... Hemangioma, Cavernous, Central Nervous System. C14.907.934.385.500 C14.240.850.875.249. C14.907.454.385.500. Hematocrit G9.188. ... Hereditary Central Nervous System Demyelinating Diseases. C16.320.400.393 C16.320.400.367. Herpes Simplex Virus Protein Vmw65 ...
Arteriovenous FistulasSpinal CordCongenitalTumorsAneurysmsLesionsAVMsDisordersVenousBlood vesselsDiagnosisHemorrhageAbnormalityLesionSpineChiariCerebral vascularEndothelialAbnormalitiesDiseasesPeripheral nervouArachnoidDysfunctionAngiographyOccurLocated in the supratentorialFamilialFetalInfectionsAbnormalRenalRespiratoryNeurologistsPatientsDorsalInfectionHumansCapillariesNeurologyEndotheliumClassification
Arteriovenous Fistulas1
- [ 2 ] Vascular malformations of the spinal cord include spinal arteriovenous malformations (AVMs), dural arteriovenous fistulas (AVFs), spinal hemangiomas , cavernous angiomas , and aneurysms . (medscape.com)
Spinal Cord15
- An arteriovenous malformation can develop anywhere in the body but common locations include the brain and spinal cord - though overall, brain AVM s are rare. (mayoclinic.org)
- Vascular lesions of the brain and spinal cord are commonly encountered in clinical practice and can lead to diagnostic, prognostic, and therapeutic challenges. (medscape.com)
- The etiology of vascular malformations of the spinal cord has not been clearly defined. (medscape.com)
- The spinal cord is composed of neuronal pathways, glial tissue, and interwoven vascular structures that perfuse the spinal parenchyma. (medscape.com)
- Spinal cord vascular malformations (arterial and venous) represent a heterogeneous group of blood vessel disorders that affect the spinal cord parenchyma either directly or indirectly. (medscape.com)
- [ 5 ] Patients with these malformations become symptomatic because the AVF creates venous congestion and hypertension, resulting in hypoperfusion, hypoxia, and edema of the spinal cord. (medscape.com)
- This malformation consists of a tightly compacted group of arterial and venous vessels (nidus) inside a short segment of the spinal cord. (medscape.com)
- Physicians in Wilmington Health Neurology diagnose and treat disorders of the central and peripheral nervous systems, which include the brain, spinal cord, and nerves in the body. (wilmingtonhealth.com)
- The Department of Adult and Pediatric Diagnostic, Interventional Neuroradiology offers the widest range of services for the diagnostics and treatment of diseases of the brain, spinal cord and peripheral nerves using the advanced imaging systems. (bookinghealth.com)
- Neurosurgery is the medical specialty concerned with the prevention, diagnosis, treatment, and rehabilitation of disorders which affect any portion of the nervous system including the brain, spine, spinal cord, peripheral nerves, and extra-cranial cerebrovascular system. (absoluteastronomy.com)
- Bacterial abscesses, spinal cord tumours, vascular malformations and haematomas can be excluded with neuro-imaging methods. (who.int)
- These findings were typical of spinal cord syndrome, warranting urgent imaging of the cord to exclude a space-occupying lesion such as a neoplasm, vascular malformation or haemorrhage. (who.int)
- Vascular neurologists at UK HealthCare specialize in the treatment and management of vascular disorders that affect the central nervous system, which is made up of the brain and spinal cord. (uky.edu)
- Cavernous malformations can occur anywhere in the body, but usually produce serious signs and symptoms only when they occur in the brain and spinal cord (which are described as cerebral). (medlineplus.gov)
- In its early years, the Institute's staff focused on dealing with long-term effects and complications of injuries of the skull, brain and spinal cord, the peripheral and in particular autonomic nervous system. (kiev.ua)
Congenital6
- Intradural parenchymal malformations often occur in a younger patient population and are believed to be congenital. (medscape.com)
- The term "malformation" can imply a congenital (developmental) or acquired lesion, and these terms ("malformation" and "lesion") are used interchangeably. (medscape.com)
- Conclusion: The common congenital brain anomalies in our environment are congenital hydrocephalus, aqueductal stenosis, arteriovenous malformations, cerebral atrophy and arachnoid cysts. (bvsalud.org)
- Classical anatomical embryology will be emphasized, including consideration of major congenital malformations. (iu.edu)
- Methods: We performed a population-based case-control study by linking the New York State Congenital Malformations Registry to birth certificates for the years 1992-2006. (cdc.gov)
- Most anomalies detected in animal studies have been observed in clinical and epidemiologic studies of maternal fever and febrile illness, including neural-tube defects, microphthalmia, congenital cataracts, abdominal wall defects, congenital heart defects, microcephaly, limb defects, craniofacial malformations, and renal defects ( Edwards 2006 ). (cdc.gov)
Tumors3
- Abnormalities seen on brain imaging include hemi-megalencephaly, migrational abnormalities, agenesis of the corpus callosum, asymmetrical or symmetrical ventricular dilatation, focal cerebral atrophy with porencephalic ventricular dilatation, hemiatrophy, diffuse cerebral atrophy, cerebellar hypoplasia or atrophy, vascular abnormalities, and rarely tumors [ 4 ]. (cdlib.org)
- The Department of Interventional Radiology offers the full range of imaging examinations, as well as innovative image-guided minimally invasive techniques for the treatment of tumors, vascular diseases and internal pathologies (for example, CT, MRI, PET-CT, SPECT). (bookinghealth.com)
- Hemangiomas are the most common nonmalignant vascular tumors of infants, characterized by rapid endothelial cell proliferation and hypercellularity 1,2 . (bvsalud.org)
Aneurysms3
- The department's specialists have rich experience and exceptional professional skills in the field of interventional procedures for acute and chronic vascular diseases, such as ischemic strokes, brain hemorrhages, cerebral artery stenosis, brain aneurysms, and vascular malformations. (bookinghealth.com)
- The most popular interventional therapeutic procedures include clipping and coiling of cerebral vascular aneurysms, as well as cerebral vascular malformations. (bookinghealth.com)
- 10. Patients with intracranial aneurysms requiring treatment or arterial venous malformations (AVMs) requiring treatment at any time. (who.int)
Lesions4
- Overall, AVMs are best imaged via MRI, which can uniquely show these lesions as a tangle of vascular channels that appear as flow voids. (medscape.com)
- Arteriovenous malformations and other vascular lesions of the central nervous system fact sheet. (medtronic.com)
- OBJECTIVES: To review the authors' experience with three pediatric intramedullary cavernous malformations, review the previous literature, and discuss the surgical management for these rare lesions. (elsevier.com)
- All these devices are used not only for the diagnostics, but also for interventional procedures to treat obstructions, stenoses and other pathological vascular lesions in the head, neck and spine. (bookinghealth.com)
AVMs2
- AVMs are more likely than other types of vascular malformations to be clinically symptomatic. (medscape.com)
- This article focuses on the most prevalent spinal vascular malformations-AVMs and AVFs. (medscape.com)
Disorders2
- Vascular disorders of the spine are more rare than cerebral vascular entities but can result in significant morbidity. (medscape.com)
- This graduate course uses a multidisciplinary approach to integrate the basic with the clinical neurosciences in understanding the human nervous system and select neurological disorders. (iu.edu)
Venous4
- venous angiomas, a more common type of cerebrovascular malformation, account for 64% of cases. (medscape.com)
- Central nervous system (CNS) vascular malformations encompass a wide range of arterial and venous anomalies with various presentations, a variable clinical course, and a variety of complication rates. (medscape.com)
- Spinal vascular malformations consist of an abnormal connection between normal arterial and venous pathways. (medscape.com)
- These vascular malformations develop near a spinal dural artery, forming an abnormal arteriovenous communication with the venous circulation. (medscape.com)
Blood vessels4
- In a brain arteriovenous malformation, blood passes directly from arteries to veins through a tangle of blood vessels. (mayoclinic.org)
- A brain arteriovenous malformation (AVM) is a tangle of blood vessels that connects arteries and veins in the brain. (mayoclinic.org)
- During angiogenesis in the developing central nervous system (CNS), endothelial cells (EC) detach from blood vessels growing on the brain surface, and migrate into the expanding brain parenchyma. (biomedcentral.com)
- The department is equipped with modern technical devices, including 64-slice CT scanner, 1,5 and 3,0 Tesla MRI, biplane angiography system with 3D imaging of the blood vessels and bone structures, system for myelography of the entire spine and ultrasound scanners. (bookinghealth.com)
Diagnosis1
- In this case vascular dementia is the diagnosis which comes to mind. (braindiseases.blog)
Hemorrhage3
- A brain arteriovenous malformation may not cause any signs or symptoms until the AVM ruptures, resulting in hemorrhage. (mayoclinic.org)
- This causes a high-flow system, which can lead to potentially life-threatening hemorrhage (bleeding), 2 especially in young adults. (medtronic.com)
- Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations. (medtronic.com)
Abnormality2
- The stroke was caused by a cavernous malformation cavernoma (CM). It is a vascular abnormality in the central nervous system, which leads to a cluster of dilated vessels. (cfschools.org)
- The often brief, stereotyped premonitory symptoms (aura) at the onset of some seizures may localize the central nervous system (CNS) abnormality responsible for seizures. (mhmedical.com)
Lesion2
- Cavernomas are an uncommon lesion seen in Cavernomas represent around 5% to 10% of all central neurological practice that can occasionally rupture. (bvs.br)
- The identification of hemangiomas by examining the record cards of the newly-born at the maternity hospital, noting the location of the lesion(s), child's gender and weight, prematurity, Apgar score and any additional malformations. (bvsalud.org)
Spine1
- See the MRI below showing spinal malformation of the thoracic spine. (medscape.com)
Chiari3
- An incidental MRI finding might, for example, be a small aneurysm found when a child with migraine headaches is sent for an MRI, or a Chiari malformation on the scan of child with a concussion after falling off playground equipment, said Dr Maher. (medscape.com)
- The most common incidental findings referred for specialist evaluation are pineal cysts, arachnoid cysts, and Chiari malformations, all of which may be asymptomatic. (medscape.com)
- He used the case of the mother of a child with a Chiari malformation who in a blog expressed her extreme disappointment that the neurosurgeon recommended against surgery, "which was the right decision for that particular case in my opinion," said Dr Maher. (medscape.com)
Cerebral vascular1
- 11. Presence of central nervous system (CNS) disease(s) other than epilepsy including but not limited to infections of the CNS (e.g., syphilis, Lyme disease, borreliosis, viral or bacterial meningitis/encephalitis, human immunodeficiency virus [HIV] encephalopathy), cerebral vascular disease, Parkinson's disease, traumatic brain injury, alcoholic encephalopathy within three (3) years prior to Screening. (who.int)
Endothelial1
- The precise mechanisms responsible for the development and growth of dural arteriovenous fistula (DAVF) remain unclear, but it has been hypothesized that vascular endothelial growth factor (VEGF) might be involved in the pathogenesis. (nih.gov)
Abnormalities1
- It is particularly involved in the patient care of rare, severe and complex diseases such as ectodermal dysplasias, epidermolysis bullosa, ichthyosis, incontinentia pigmenti, cutaneous and subcutaneous vascular malformations, Netherton syndrome, pigmentary abnormalities of the skin , etc. (aphp.fr)
Diseases5
- Molecular biology has revolutionized the diagnostics of causing a variety of diseases, from monosymptomatic of infectious diseases through the introduction of febrile infection to severe infection in the central nervous more sensitive and specifi c diagnostic tests. (cdc.gov)
- The medical facility provides imaging diagnostics and low-traumatic image-guided interventional treatment of nervous system diseases. (bookinghealth.com)
- Interventional radiology is a specialty of radiology, in which image-guided procedures are used to diagnose and treat a multitude of diseases across all body systems. (absoluteastronomy.com)
- certain localized infections - see body system-related chapters infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium [except obstetrical tetanus] (O98. (who.int)
- A point to remember here is that these white matter changes visualized on the brain MRI can be seen in many different diseases of the brain-diseases as diverse as leukodystrophies, nutritional deficiencies, toxic drug exposures, vascular dementia and multiple sclerosis (MS). So the radiologist's report invariably lists all these differential diagnoses and when patients read their MRI report they get worried. (braindiseases.blog)
Peripheral nervou2
- Emphasis on providing fundamental knowledge of the structure/function of major organ systems, musculoskeletal system, peripheral nervous system and vascular supply to the trunk, head and neck, limbs, and back. (iu.edu)
- Departments of neurooncology, acute injury of the central and peripheral nervous system, neuro-vascular pathology, restorative neurosurgery and pediatric neurosurgery were created. (kiev.ua)
Arachnoid1
- In the central nervous system, the subarachnoid cavity is the interval between the arachnoid membrane and pia mater. (absoluteastronomy.com)
Dysfunction3
- The associated neurological manifestations include mental retardation, seizures, language disabilities and motor system dysfunction. (cdlib.org)
- Common manifestations of central nervous system involvement include mental retardation, seizures, language disabilities, and motor system dysfunction. (cdlib.org)
- Autoimmune pemphigus is a bullous disease of the skin and mucous membranes (mouth, internal genitalia, anus, etc.) in which the body produces antibodies against its own skin and/or mucous membranes (autoantibodies) as a result of an immune system dysfunction. (aphp.fr)
Angiography2
- The department's medical team has state-of-the-art computed tomography (CT), magnetic resonance imaging (MRI), and MR angiography systems that are actively used for diagnosing patients and therapeutic procedures. (bookinghealth.com)
- Contrast-enhanced MRI angiography demonstrated normal vascular structures. (who.int)
Occur1
- It involves a defect in the blood vessel system thought to occur mostly during fetal development - but cases where and AVM has developed later in life have also been reported. (medtronic.com)
Located in the supratentorial1
- An arteriovenous malformation (AVM) is a tangled cluster of vessels, typically located in the supratentorial portion of the brain, in which arteries connect directly to veins without an intervening capillary bed. (medscape.com)
Familial3
- The familial form is passed from parent to child, and affected individuals typically have multiple cerebral cavernous malformations. (medlineplus.gov)
- Mutations in at least three genes, KRIT1 (also known as CCM1 ), CCM2 , and PDCD10 (also known as CCM3 ), cause familial cerebral cavernous malformations. (medlineplus.gov)
- Mutations in these three genes account for 85 to 95 percent of all cases of familial cerebral cavernous malformations. (medlineplus.gov)
Fetal2
- Adverse reactions that might require further evaluation or therapy include inadvertent inoculation, generalized vaccinia (GV), eczema vaccinatum (EV), progressive vaccinia (PV), postvaccinial central nervous system disease, and fetal vaccinia. (cdc.gov)
- Fetal alcohol syndrome (FAS) involves a recognizable pattern of dysmorphic features, growth deficiency, structural brain malformations, and neurobehavioral disabilities. (medicalhomeportal.org)
Infections2
- To from 3 genera ( Enterovirus , Hepatovirus , and Parechovirus ) study a possible association between SAFV and infections have been fi rmly established as being capable of causing in the human central nervous system, we designed a real- time PCR for SAFV and tested cerebrospinal fl uid (CSF) clinically signifi cant disease in humans. (cdc.gov)
- This is a new book in the ISN series that provides a comprehensive overview of infections affecting the central nervous system written by a range of international experts. (intsocneuropathol.com)
Abnormal2
- An arteriovenous malformation, AVM, is an abnormal connection between arteries and veins. (medtronic.com)
- The vascular walls in CMs demonstrated abnormal ultrastructure with no basement membranes and astrocytic foot processes. (cornell.edu)
Renal1
- No studies were located in humans or animals regarding the effects on the respiratory, hematological, musculoskeletal, hepatic, renal, and dermal/ocular systems after inhalation exposure to thallium. (cdc.gov)
Respiratory1
- Anatomic ontologies for both species were constructed as partonomic hierarchies and organized along the lung's proximal-distal axis into respiratory, vascular, neural, and immunologic components. (biomedcentral.com)
Neurologists2
Patients1
- To enroll or randomize Eligible patients, research coordinators obtain informed consent and access the automated web-based system through Internet based program (available 24 hours/day). (liu.edu)
Dorsal3
- All the malformations abutted the dorsal pial surface and created a blue discoloration, which was evident after opening the dura. (elsevier.com)
- The Edinger-Westphal nucleus is rostral to the caudal central nucleus and mainly dorsal to the lateral somatic cell columns. (neurosurgicalatlas.com)
- The Edinger-Westphal (EW) nucleus extends along the raphe, rostral to the caudal central nucleus and mainly dorsal to the lateral somatic columns (Figs. 1A and 1B). (neurosurgicalatlas.com)
Infection1
- These medications act by suppressing the immune system, leaving the patient exposed to severe infection and at risk of cancer. (hrb.ie)
Humans1
- Propranolol, a pleiotropic β-adrenergic blocker, has been anecdotally reported to reduce cerebral cavernous malformations (CCMs) in humans. (duke.edu)
Capillaries1
- These malformations do not benefit from intervening capillaries. (medscape.com)
Neurology1
- Why choose UK HealthCare for stroke & vascular neurology? (uky.edu)
Endothelium1
- Transmission electron microscopy was used to examine the vascular walls, endothelium, subendothelium, and cytoplasmic organelles. (cornell.edu)
Classification1
- All headaches fall into 1 of 2 classification systems: primary and secondary headache Headache The symptom of pain in the cranial region. (lecturio.com)