An increased response to stimulation that is mediated by amplification of signaling in the CENTRAL NERVOUS SYSTEM (CNS).
The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.
Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
Adjustment and manipulation of the vertebral column.
Musculoskeletal manipulation based on the principles of OSTEOPATHIC MEDICINE developed in 1874 by Dr Andrew Taylor Still.
The planned and carefully managed manual movement of the musculoskeletal system, extremities, and spine to produce increased motion. The term is sometimes used to denote a precise sequence of movements of a joint to determine the presence of disease or to reduce a dislocation. In the case of fractures, orthopedic manipulation can produce better position and alignment of the fracture. (From Blauvelt & Nelson, A Manual of Orthopaedic Terminology, 5th ed, p264)
Various manipulations of body tissues, muscles and bones by hands or equipment to improve health and circulation, relieve fatigue, promote healing.
Sensation of enjoyment or gratification.
The process in which specialized SENSORY RECEPTOR CELLS transduce peripheral stimuli (physical or chemical) into NERVE IMPULSES which are then transmitted to the various sensory centers in the CENTRAL NERVOUS SYSTEM.
The act of "taking account" of an object or state of affairs. It does not imply assessment of, nor attention to the qualities or nature of the object.
Uncontrolled release of a chemical from its containment that either threatens to, or does, cause exposure to a chemical hazard. Such an incident may occur accidentally or deliberately.
Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.
A state of reduced sensibility and response to stimuli which is distinguished from COMA in that the person can be aroused by vigorous and repeated stimulation. The person is still conscious and can make voluntary movements. It can be induced by CENTRAL NERVOUS SYSTEM AGENTS. The word derives from Latin stupere and is related to stunned, stupid, dazed or LETHARGY.
An institute of the CENTERS FOR DISEASE CONTROL AND PREVENTION which is responsible for assuring safe and healthful working conditions and for developing standards of safety and health. Research activities are carried out pertinent to these goals.
An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
The local lymph node assay (LLNA) is an alternative method for the identification of chemicals that have the ability to cause skin sensitization and allergic contact dermatitis. Endpoints have been established so fewer animals are required and less painful procedures are used.
Inorganic compounds that contain phosphorus as an integral part of the molecule.
Respirators to protect individuals from breathing air contaminated with harmful dusts, fogs, fumes, mists, gases, smokes, sprays, or vapors.
Clothing designed to protect the individual against possible exposure to known hazards.
Disorders of the choroid including hereditary choroidal diseases, neoplasms, and other abnormalities of the vascular layer of the uvea.
An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.
Fabric or other material used to cover the body.
Beaches, both natural and man-made, used for bathing and other activities.
A United States organization of distinguished scientists and engineers established for the purpose of investigating and reporting upon any subject of art or science as requested by any department of government. The National Research Council organized by NAS serves as the principal operating agency to stimulate and support research.
Identifies, for study and analysis, important issues and problems that relate to health and medicine. The Institute initiates and conducts studies of national policy and planning for health care and health-related education and research; it also responds to requests from the federal government and other agencies for studies and advice.
A branch of psychology which investigates the correlation between experience or behavior and the basic neurophysiological processes. The term neuropsychology stresses the dominant role of the nervous system. It is a more narrowly defined field than physiological psychology or psychophysiology.
Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.
The science and technology dealing with the procurement, breeding, care, health, and selection of animals used in biomedical research and testing.
The number of offspring produced at one birth by an oviparous or ovoviviparous animal.
Spontaneous or voluntary recreational activities pursued for enjoyment and accessories or equipment used in the activities; includes games, toys, etc.
A person involuntarily owned or controlled by another and exploited for forced or compulsory work or service.
Animal behavior associated with the nest; includes construction, effects of size and material; behavior of the adult during the nesting period and the effect of the nest on the behavior of the young.
The process of laying or shedding fully developed eggs (OVA) from the female body. The term is usually used for certain INSECTS or FISHES with an organ called ovipositor where eggs are stored or deposited before expulsion from the body.
Apparatus and instruments that generate and operate with ELECTRICITY, and their electrical components.
Tools used in dentistry that operate at high rotation speeds.
Mercury chloride (HgCl2). A highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant.
The capacity to conceive or to induce conception. It may refer to either the male or female.
Medical practice or discipline that is based on the knowledge, cultures, and beliefs of the people in EAST ASIA.
The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.
Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.
The reproductive cells in multicellular organisms at various stages during GAMETOGENESIS.
A highly poisonous compound used widely in the manufacture of plastics, adhesives and synthetic rubber.
Hydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Uptake of substances through the SKIN.
Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.
Tests or bioassays that measure the skin sensitization potential of various chemicals.
Enzymes catalyzing the dehydrogenation of or oxidation of compounds containing primary amines.

Glutamate transporter subtype 1 (GLT-1) activator ceftriaxone attenuates amphetamine-induced hyperactivity and behavioral sensitization in rats. (1/44)

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Altered central sensitization in subgroups of women with vulvodynia. (2/44)

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How to explain central sensitization to patients with 'unexplained' chronic musculoskeletal pain: practice guidelines. (3/44)

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Central sensitization of nociceptive neurons in rat medullary dorsal horn involves purinergic P2X7 receptors. (4/44)

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Importance of associative learning processes for one-trial behavioral sensitization of preweanling rats. (5/44)

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Peripheral injury induces long-term sensitization of defensive responses to visual and tactile stimuli in the squid Loligo pealeii, Lesueur 1821. (6/44)

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Spinal cord injury triggers an intrinsic growth-promoting state in nociceptors. (7/44)

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The development and psychometric validation of the central sensitization inventory. (8/44)

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January 16, 2013. Have you heard the term central sensitivity syndrome (CSS)? Its a good one to know - researchers are using it more and more as an umbrella term for fibromyalgia, chronic fatigue syndrome and several other related illnesses.. These conditions have been called a lot of things, ranging from not real to functional somatic syndromes to neuroendocrineimmune disease. However, as researchers learn more about them, some are coming to the conclusion that CSS fits best because its based on their common underlying physiology - central sensitization. Thats what makes us hyper-sensitive to pain, sensory input, and, well, the world.. See what CSS means and which illnesses it covers:. ...
Do you remember my massive post about CSS, Central Sensitivity Syndrome? The basic premise was that some peoples hyper-sensitivity may be related to an amplification of certain neurotransmitter pathways which then cause reactivity, pain and mood changes. I detailed what kind of pathways go wrong and the mainstream meds currently being used to dampen them.…
Does acetaminophen activate endogenous pain inhibition in chronic fatigue syndrome-fibromyalgia and rheumatoid arthritis: a double-blind randomized controlled cross-over trial. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
For some with Central Sensitization, electrical stimulation devices are a godsend. However, for others its a nightmare. Fortunately, electrical sensitivities are rare. For those without electrical sensitivity, there are several wonderful devices that may help you with your pain. The first is the well-known TENS Unit. Another is the lesser… ...
I was initially started on prescription medications for ADHD, and those resulted in new symptoms/side effects, and they continued to add more drugs to treat the side effects instead of taking me off the medications. It wasnt long before I was having psychotic episodes due to the medications because the side effects were so severe. Then, they put me on anti-psychotics which landed me institutionalized. One month later my Chronic Pain Specialist took me off all my medications and within 6 months, most of the side effects were gone and I was a completely different person (still disabled), but living healthy, strong, and independently.. Basically, I was severely high on drugs stating at age 7. I never had a chance. It got so bad my mother signed me over to the state because she couldnt deal with it anymore and was terrified of me. Then the state signed me back over to my mother because they couldnt deal with me anymore and were terrified of me. And then I spent 3 years living on and off the ...
Central sensitivity syndrome is a rising umbrella term for fibromyalgia, chronic fatigue syndrome and related conditions. See what that means.
INTRODUCTION The stimulus of surgical trauma provokes peripheral and central sensitivity, with modification of neurons and resulting in allodynia, hyperalgesia and increase of postoperative pain intensity1. It also causes increase in the concentrations of cytokines 2,3. Pro-inflammatory cytokines (TNF-α, IL-1, IL-6, IL-8) indirectly modulate pain through the release of substances like nitric oxide, oxygen free radicals, prostaglandins, and excitatory amino acids from microglia and astrocytes, inducing peripheral and central sensitivity and hyperalgesia 4. NMDA receptors have an important role in processing pain. The activation of these receptors by excitatory neurotransmitters, especially glutamate, is essential to the development of central sensitivity and amplification of pain response 1. Some drugs have been investigated to prevent or modify these alterations in the central nervous system. Ketamine is an antagonist of NMDA receptors and the S(+)-ketamine isomer is more powerful than the ...
This study describes the patient characteristics and healthcare utilization of a chronic pain population within an integrated healthcare system in northern California.
The nervous system sensitization process is usually triggered by something that is perceived as a threat. The trigger can be an accident, an emotional response, an immune response or any number of eve
Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central sensitization. Central sensitization manifests as pain hypersensitivity, particularly dynamic tactile allodynia, secondary …
Fibromyalgia is currently understood to be a disorder of central pain processing or a syndrome of central sensitivity. Clauw describes the syndrome as a diffuse problem of sensory
Hi everyone, My doctor told me I have this, and thats why the pain is getting steadily stronger even though the IC probably isnt. I say probably isnt because pain is the only symptom at this point. There were some urinary symptoms in the beginning (1/07) and they disappeared after a few months. I know I should be grateful for that, and I really am. Im not sure I understand, though, what central sensitization means in terms of treatment. Does anyone know if central sensitization
Preclinical Findings Presented at the 2010 Joint Annual Meeting of the International Continence Society and the International Urogynecological Association Aug 2
Chapter 5 questions at Bradley University StudyBlue - Learn what central sensitization means, For example, you may not have a It may be due to any combination of the following:
This web site is run by an Arthritis Specialist based in Dubai, United Arab Emirates. On this site you will find news about the latest in arthritis, information about research results in the field, tips and information and diet and exercise, and much more.. More ...
Impaired central pain modulation is implicated in the pathophysiology of chronic pain. In this controlled experiment, we evaluated whether partial sleep loss altered endogenous pain inhibition and reports of spontaneous pain. Thirty-two healthy females were studied polysomnographically for 7 nights. …
Thorn, Beverly, Day, Melissa, Burns, John, Kuhajda, Melissa, Gaskins, Susan, Sweeney, Kelly, McConley, Regina, Ward, L Charles and Cabbil, Chalanda. (2011) Randomized trial of group cognitive behavioral therapy compared with a pain education control for low-literacy rural chronic pain population. Pain. 152(12), pp. 2710 - 2720. https://doi.org/10.1016/j.pain.2011.07.007 ...
The BfArM would like to draw attention to the recent SCENIHR publication regarding the use of surgical meshes in urogynecological surgery.
Click the blue hyper link introduction to pericytes in the reference section. See also the hyperlink Regenexx.com in the reference section. Historical Background. The history and description of chronic pain actually began slightly prior to the Civil War. Dr. Thomas Weir Mitchell, described Causalgia after the Civil War, where soldiers returning from battle with chronic pain developed pain that was not in the location of their original injuries. He noted that the pain was in a different nerve distribution and thus, seemed to be a condition of the nerves.. Chronic Pain Theory. Currently, thanks to the remarkable work of a single physician in Christchurch, New Zealand, Dr. John Lyftogt has provided a new working hypothesis in chronic pain. That is neurogenic inflammation of the unregulated peptidergic sensory nervous system. His hypothesis is the up regulation of the peptidergic nervous system sensitization and swelling is responsible for the tenderness and expression of pain in chronic clinical ...
Background Opioid analgesics such as morphine and meperidine have been used to control moderate to severe pain for many years. However, these opioids have many side effects, including the development...
1005 Dr. D.B. Todd Jr. Boulevard Nashville, Tennessee 37208 , 615.327.5525. The Office for Research is located in room 2203 of the Harold D ...
Semantic Scholar extracted view of Pain perception and endogenous pain modulation in angina pectoris. by Christine A. Droste et al.
Subjective. - Getting paresthesia down the R LE that began 2 weeks ago after a car ride…has peripheralized since initial event.. - Symptoms are aggravated with static sitting or standing…onset ranging from seconds to minutes.. - Has tried loading/unloading MDT strategies, neurodynamics, Mulligan techniques, IASTM, compression wrapping, etc…all to no avail.. Objective (major findings). - Limited B Apleys scratch (1 per FMS scoring). - Negative slump and ASLR. - Painful lumbar motions of extension, right rotation and sidebend. R sidebend was limited.. - Negative thomas test on left, positive on right. - Slight limitations in active seated hip IR B, R,L.. - Adduction lift scores 1/5 B.. My Impression. If I were to classify Erson, it seems his symptoms would seems to be more dominant as peripheral nociceptive ischemic and central sensitivity (he stated he has always had findings with his back). I was less inclined to think he had peripheral neuropathic issues, at least yet, based on ...
Hi I have recently been diagnosed with Central Sensitisation and Chronic Migrainous State. This is after three years of a range of strange symptoms which I did
The proposed study intends to utilize a psychobehavioral protocol from Darnall and colleagues to deliver a single session behavioral medicine for pain intervention for the spine surgery patient entitled TREK (Transform, Restore, Empower, Knowledge) for Surgical Success (TREK for SS). The intervention is based off of the above noted evidence based 2 hour pain psychology class that has been used in the chronic pain population and is also currently being tested in other surgical populations. Use of this established and evidenced based treatment for the proposed project enhances the treatment fidelity. The proposed project addresses questions in the literature such as the benefits of this class in an in-person or online format and its adaptability and effectiveness in the spine surgery population.. The primary objective of the proposed project is to determine the feasibility of a single session digital behavioral medicine for pain intervention (TREK for SS) offered the perioperative period of ...
The American Urogynecologic Society and the International Urogynecological Association have honored the University of Alabama at Birminghams Dep...
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Understanding the perception of pain is important in the treatment of many conditions. When a tissue in the body is damaged, peripheral sensitization of nociceptors occurs as a protective mechanism by the body in order to prevent further use of a damaged structures (which if used, could further damage the tissue as well as surrounding…
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TriAgain, my experience has been similar. Triathlon to joint pain. Except mine started with my hips and the other important difference I have to say Ive sadly had no progress. What I find works best for me is flow. By which I mean if I get into a state where I am completely and utterly absorbed by whatever Im doing and am happy then the pain seems to resolve to some extent. Im not sure if this is the bodys endogenous pain killers - endomorphine and endocannabinoid pathways or something else. It would kind of make sense as it seems to last for a while afterwards. Its not just a case of being diverted. It lasts longer than the diversion. I have been increasingly speculating that being stressed and focussed on the pain not just amplifies the pain which I think is pretty well established in the academic literature but causes actual joint damage. Ive actually found a serious academic paper which kind of makes this leap. The nervous system goes two ways. You sensory receptors send signals to the ...
Chemists at LMU Munich have collaborated with colleagues at Berkeley and Bordeaux to perform a series of lab experiments on pain inhibition and pain-sensitive neurons. They have discovered something like a pain switch, allowing the inhibition of the activity of pain-sensitive neurons. Findings were published in February of this year in Nature Methods. The researchers…
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Background Fibromyalgia Syndrome (FMS) is a persistent and debilitating disorder estimated to impair the quality of life of 2-4% of the population, with 9:1 female-to-male incidence ratio. FMS is an important representative example of central nervous system sensitization and is associated with abnormal brain activity. Key symptoms include chronic widespread pain, allodynia and diffuse tenderness, along with fatigue and sleep disturbance. The syndrome is still elusive and refractory. The goal of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) on symptoms and brain activity in FMS. Methods and Findings A prospective, active control, crossover clinical trial. Patients were randomly assigned to treated and crossover groups: The treated group patients were evaluated at baseline and after HBOT. Patients in the crossover-control group were evaluated three times: baseline, after a control period of no treatment, and after HBOT. Evaluations consisted of physical examination, including
BACKGROUND Fibromyalgia Syndrome (FMS) is a persistent and debilitating disorder estimated to impair the quality of life of 2-4% of the population, with 9:1 female-to-male incidence ratio. FMS is an important representative example of central nervous system sensitization and is associated with abnormal brain activity. Key symptoms include chronic widespread pain, allodynia and diffuse tenderness, along with fatigue and sleep disturbance. The syndrome is still elusive and refractory. The goal of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) on symptoms and brain activity in FMS. METHODS AND FINDINGS A prospective, active control, crossover clinical trial. Patients were randomly assigned to treated and crossover groups: The treated group patients were evaluated at baseline and after HBOT. Patients in the crossover-control group were evaluated three times: baseline, after a control period of no treatment, and after HBOT. Evaluations consisted of physical examination, including
Background Fibromyalgia Syndrome (FMS) is a persistent and debilitating disorder estimated to impair the quality of life of 2-4% of the population, with 9:1 female-to-male incidence ratio. FMS is an important representative example of central nervous system sensitization and is associated with abnormal brain activity. Key symptoms include chronic widespread pain, allodynia and diffuse tenderness, along with fatigue and sleep disturbance. The syndrome is still elusive and refractory. The goal of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) on symptoms and brain activity in FMS. Methods and Findings A prospective, active control, crossover clinical trial. Patients were randomly assigned to treated and crossover groups: The treated group patients were evaluated at baseline and after HBOT. Patients in the crossover-control group were evaluated three times: baseline, after a control period of no treatment, and after HBOT. Evaluations consisted of physical examination, including
There also appears to be a connection between IC and other syndromes such as chronic fatigue syndrome (CFS), fibromyalgia, irritable bowel syndrome and vulvodynia and dyspareunia (pain on intercourse).All may have a connection between what has been called Central Sensitivity Syndrome (CSS).. Patients with CSS become sensitised to things that are processed by the central nervous system: lights, odours, smell, touch and pressure on the body. This explains the connection between the above conditions and also the following: migraines, restless legs syndrome, multiple chemical sensitivity, temperomandibular joint dysfunction (TMJ) and dysmenorrhoea (painful periods). Some patients have more than one condition, and this helps make sense of the connection.. It appears irritable bowel syndrome, interstitial cystitis and reproductive and pelvic pain may have a connection through nerve pathways in the pelvis. Researchers have demonstrated a cross-sensitisation between nerves in the bladder, bowel and ...
Scotopic sensitivity syndrome, also known as Irlen Syndrome and Visual Stress Syndrome, approximating in some ways to Meares Irlen syndrome, and Visual Stress, refers to visual perceptual disorder(s) affecting primarily reading and writing based activities.
Scotopic sensitivity syndrome is a disorder that leads to a variety of symptoms that are related to vision. The signs of scotopic...
Abramowitch, S.D., 2013, Mesh Complications: Hypothesizing About the Cause, American Urogynecological Societys Mesh special Interest Group, Las Vegas, NV.. Abramowitch, S.D., 2013, Trying to Clean Up the Mess of Urogynecological Mesh, Biomedical Engineering Graduate Seminar Series, The University of Akron.. Abramowitch, S.D., 2013, Urogynecological Mesh: The Data is Long Overdue, Engineering Science and Mechanics Seminar Series, Virginia Tech University.. Abramowitch, S.D., Maiti, S., Moalli, P., Pal, S., and Thunes, J.R., 2013, Stiffness Mismatch between Prolapse Meshand Vaginal Tissue Impacts Stresses in the Vagina, 34th Annual Meeting of American Urogynecologic Society, Las Vegas, NV.. Barone, W.R., Amini, R., Maiti, S., Moalli, P.A., and Abramowitch, S.D., 2013, Surface Curvature of CommonProlapse Meshes Alters under Variable Loading Conditions, 34th Annual Meeting of American Urogynecologic Society, Las Vegas, NV.. Barone, W.R., Moalli, P.A., and Abramowitch, S.D., 2013, ...
OBJECTIVE: The neural mechanisms of pain in knee osteoarthritis (OA) are not fully understood, and some patients have neuropathic-like pain associated with central sensitization. To address this, we undertook the present study in order to identify central sensitization using neuroimaging and PainDETECT and to relate it to postarthroplasty outcome. METHODS: Patients awaiting arthroplasty underwent quantitative sensory testing, psychological assessment, and functional magnetic resonance imaging (fMRI). Neuroimaging (fMRI) was conducted during punctate stimulation (n = 24) and cold stimulation (n = 20) to the affected knee. The postoperative outcome was measured using the Oxford Knee Score, patient-reported moderate-to-severe long-term pain postarthroplasty, and a range of pain-related questionnaires. RESULTS: Patients with neuropathic-like pain presurgery (identified using PainDETECT; n = 14) reported significantly higher pain in response to punctate stimuli and cold stimuli near the affected joint (P | 0
Ethnic differences in central sensitization of pain processing and stress-relevant endogenous pain regulatory mechanisms were examined. Forty-four African Americans (AAs; 50% women) and 44 non-Hispanic Whites (nHWs; 50% women) matched for socioeconomic status, were tested for pain responses to the temporal summation of heat pulses and ischemic and cold pain. Resting and stress blood pressure (BP) and norepinephrine (NE) were assessed. AAs had heightened pain responses to all 3 pain tasks relative to nHWs. In nHWs, higher BP and NE were related to reduced pain. In AAs, there was no relationship between BP and pain, but higher NE was related to increased pain. This study provides evidence for ethnic differences in centrally mediated pain and extends prior research demonstrating ethnic differences in endogenous pain regulatory mechanisms. These results have implications for understanding biobehavioral factors contributing to ethnic disparities in clinical pain ...
A 20 year old myopic Sudanese female presented at our hospital with a central visual field defect of her right eye, associated with photopsia. Visual acuity was 0.3; intraocular pressure was 16 mm Hg. Funduscopic examination of the affected eye showed some pigment epithelial alterations in the macular area, with an irregular macular reflex. Upon visual field examination, the affected eye showed a 12 dB decrease in central sensitivity, and a small blind spot enlargement was seen. No such changes were found in the left eye. OCT showed degeneration or disarray of foveal photoreceptor outer segments in the ...
These data identify the hypothalamic ObRb as a gene modulated after metformin treatment and suggest that the anorectic effects of the drug are potentially mediated via an increase in the central sensitivity to leptin ...
Bo K, Frawley HC, Haylen BT, Abramov Y, Almeida FG, Berghmans B, Bortolini M, Dumoulin C, Gomes M, McClurg D, Meijlink J, Shelly E, Trabuco E, Walker C, Wells A. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for the conservative and nonpharmacological management of female pelvic floor dysfunction. Int Urogynecol J 2017 Feb; 28 (2):191-213 Epub 2016 Dec 05 ...
Some surgeons work with other medical professionals in order to treat complex cases: such as a colorectal surgeon, urogynecological surgeon, or thoracic surgeon. This does not mean that the specialist has a lower skill set by any means. While a group of surgeons are now using robotic surgery, some have opted to continue using traditional surgical techniques. This does not mean that one is better or more qualified than the other. Surgery is not based on the tools used, but the hands controlling the tools and the knowledge behind those hands. ...
By Andy Choi OrthoSensor, the developer of sensor-assisted surgery systems and intelligent orthopedic implants based in Sunrise, Florida, has announced that its
C) no, not necessarily... it depends how much damage there is... but pain sensation is both a physiological and psychological responce... many people have very traumatic sports injuries and they dont feel the pain to much after the event... as adrenaline may well delay a pain responce... but we also have other endogenous pain killers in bodies (endogenous opioids, neurotransmitters...etc ...
MT Pinto joined Ipatimup as an Investigator Ciência 2008 (2009) of the Cancer Genetics Group and was mainly dedicated to the study of cancer related features using the CAM model. After setting up the lab and implementing several CAM assays, she established the In vivo CAM assays service at Ipatimup (2012) and founded the spin-off Expertus, CAM assays (2013-2015). MT Pinto graduated in Biochemistry (FCUP; 1999) and both MSc (FMUL; 2001) and PhD (FMUP; 2008) theses concerned the study of the endogenous pain control system in acute and chronic pain states and involved extensive use of animal models. MT Pinto has published 26 papers in international peer reviewed journals (Q1) with an H index of 12 (ResearcherID: J-2519-2013). She is co-author of two patents. ...
PMID: 22558610 Aims: To investigate the influence of noxious stimulation of the temporomandibular joint (TMJ) on conditioned pain modulation (CPM) and the possible influence of gender on such CPM effects in the craniofacial region of humans. Methods: Twenty healthy men and 20 healthy women participated in two sessions. Conditioning stimulation (CS) was standardized mechanical stimulation of pericranial muscles at a pain level of 5 on a 0 to 10 visual analog scale (VAS). Intra-articular electrical stimuli were applied to the left TMJ with an intensity around VAS = 5 (painful session). No electrical stimulation was applied in the control session. Pressure pain threshold (PPT) and pressure pain tolerance threshold (PPTol) were used as responses to pressure (test) stimuli and were assessed in the right masseter muscle and left forearm before and during TMJ stimulation in addition to the CS (during, immediately after, and 10 minutes after CS). PPT and PPTol were analyzed by multilevel analysis of ...
PHOENIX, March 7, 2014 /PRNewswire-USNewswire/ -- Stanford Researchers Show Conditioned Pain Modulation Equals Less Activity in the Human Spinal Cord.
The International Urogynecological Association (IUGA) is a non-profit international organization dedicated to the advancement of urogynecological knowledge around the world through education and the promotion of basic and clinical research on disorders of the female pelvic floor.. IUGA was founded in 1975 and has organized scientific meetings every year in nearly every corner of the world to promote the exchange of urogynecological information to thousands of physicians and healthcare providers.. Visit www.iuga.org for more information.. Privacy Policy ...
Chronic pain is associated with dysfunctional endogenous pain modulation, involving both central opioid and serotonergic (5-HT) signaling. Fibromyalgia (FM) is a chronic pain syndrome, characterized by widespread musculoskeletal pain and reduced exercise-induced hypoalgesia (EIH). In this study, we...
BACKGROUND: Current multimodal approaches for the management of non-specific patellofemoral pain are not optimal, however, targeted intervention for subgroups could improve patient outcomes. This study explores whether subgrouping of non-specific patellofemoral pain patients, using a series of low cost simple clinical tests, is possible. METHOD: The exclusivity and clinical importance of potential subgroups was assessed by applying à priori test thresholds (1 SD) from seven clinical tests in a sample of adult patients with non-specific patellofemoral pain. Hierarchical clustering and latent profile analysis, were used to gain additional insights into subgroups using data from the same clinical tests. RESULTS: 130 participants were recruited, 127 had complete data: 84 (66%) female, mean age 26 years (SD 5.7) and mean body mass index 25.4 (SD 5.83), median (IQR) time between onset of pain and assessment was 24 (7-60) months. Potential subgroups defined by the à priori test thresholds were not mutually
The following adverse events have been reported due to suburethral sling placement, any of which may be ongoing, but are not limited to: As with all implants, local irritation at the wound site and/or a foreign body response may occur, Foreign body reaction may be acute or chronic, Pain (pelvic, vaginal, groin/thigh, suprapubic, dyspareunia) (acute or chronic), Dyspareunia, Tissue responses to the mesh implant could include: erosion into organs (urethra, bladder or other surrounding tissues); exposure/extrusion into the vagina, Mesh contact with urine via erosion/exposure/extrusion may result in stone formation, scarring/scar contracture, Necrosis, fistula formation (acute or chronic), inflammation (acute or chronic), Mesh contracture, Tissue contracture, Vaginal shortening or stenosis that may result in dyspareunia and/or sexual dysfunction, Pain with intercourse that may not resolve, Exposed mesh may cause pain or discomfort to the patients partner during intercourse, Sexual dysfunction, ...
This was the first RCT to assess clinical and humanistic outcomes after pharmacist prescribing for any clinical condition compared with usual GP care, and the first RCT to specifically assess pharmacist-led management of chronic pain, compared with usual GP care. It was based on extensive development and feasibility work14 ,15 in line with MRC framework for development and evaluation of complex interventions.30 A range of validated outcome measures was included, as well as a parallel qualitative process evaluation which assessed satisfaction and acceptability. The inclusion of six practices and their associated pharmacists from both Scotland and England increased the generalisability of the findings. Pharmacists received formal training and agreed and used a common treatment algorithm which should have increased standardisation of treatment. The preponderance of women (overall 62%) and average age of 65 years reflects the wider chronic pain population1 as does the distribution of pain site.31 ...
Linear regression model-adjusted week 12 mean score by treatment group.. Purpose: To assess the severity of pain Population: Patients with pain from chronic diseases or conditions such as cancer, osteoarthritis and low back pain, or with pain from acute conditions such as postoperative pain Responsiveness: Responds to both behavioral and pharmacological pain interventions Method: Self-report or interview Scoring: Higher scores indicate more pain Range: 0-10 ...
Pain studies using electrophysiological recording (EEG, Evoked Potentials (EP) and MEG) demonstrate shifts in the frequency spectrum in the presence of chronic or induced pain, to the theta and beta frequency bands. Source localization of scalp-recorded EEG data Low-Resolution Electromagnetic Tomographic Analysis (LORETA) in patients with intractable unilateral or bilateral neuropathic pain, when compared to pain-free controls identified similar neural activity sources as reported in the literature with conventional neuroimaging methods.. Preliminary data collected at the Brain Research Laboratories, Department of Psychiatry at NYUSOM (under a research contract from PainQx) has been published demonstrating feasibility/proof of concept for an approach which uses QEEG to identify and quantify significant over and under activation of cortical and subcortical regions of interest (ROI) of the brain in a chronic pain population. Using QEEG source localization methods, this published pilot study ...
TY - JOUR. T1 - Outpatient visits versus telephone interviews for postoperative care. T2 - a randomized controlled trial. AU - Thompson, Jennifer C.. AU - Cichowski, Sara B.. AU - Rogers, Rebecca G.. AU - Qeadan, Fares. AU - Zambrano, Julissa. AU - Wenzl, Cynthia. AU - Jeppson, Peter C.. AU - Dunivan, Gena C.. AU - Komesu, Yuko M.. N1 - Publisher Copyright: © 2019, The International Urogynecological Association.. PY - 2019/10/1. Y1 - 2019/10/1. N2 - Introduction and hypothesis: Our aim was to determine whether postoperative telephone follow-up was noninferior to in-person clinic visits based on patient satisfaction. Secondary outcomes were safety and clinical outcomes. Methods: Women scheduled for pelvic surgery were recruited from a single academic institution and randomized to clinic or telephone follow-up. The clinic group returned for visits 2, 6, and 12 weeks postoperatively and the telephone group received a call from a nurse at the same time intervals. Women completed the Consumer ...
In summary, GSE elevated expression of proteins in trigeminal ganglia and TNC known to decrease neuronal excitability and suppressed CFA-induced expression of several proteins implicated in peripheral and central sensitization ...
Author: Steven Stanos. Osteoarthritic conditions and resultant pain are common in most clinicians practice. Dr. Stanos discusses the role of central sensitization in pain causation, and the benefits and risks associated with various pharmacological treatment options.. ...
Abuse of central nervous system (CNS) stimulants is common. Addiction to some CNS stimulants can quickly lead to medical, ... Drug tolerance, dependence, and sensitization as well as a withdrawal syndrome can occur. Stimulants may be screened for in ... Avois, L; Robinson, N; Saudan, C; Baume, N; Mangin, P; Saugy, M (7 January 2017). "Central nervous system stimulants and sport ... Amphetamine is a potent central nervous system (CNS) stimulant of the phenethylamine class that is approved for the treatment ...
Repeated exposure causes skin sensitization and may cause central nervous system and liver damage.[7] ... Acrylonitrile - Integrated Risk Information System, U.S. Environmental Protection Agency. *CDC - NIOSH Pocket Guide to Chemical ...
... kidneys and central nervous system. Hydrazine is documented as a strong skin sensitizer with potential for cross-sensitization ... central nervous system depression, lethargy, temporary blindness, seizures and coma. Exposure can also cause organ damage to ... nervous and respiratory systems. Common controls used for hydrazine include process enclosure, local exhaust ventilation and ... Thus, it is used as an antioxidant, an oxygen scavenger, and a corrosion inhibitor in water boilers and heating systems. It is ...
... central nervous system effects include neuronal sensitization to tactile stimuli and mediation of some of the effects of ... mediate many of the central and peripheral physiologic functions of serotonin. Cardiovascular effects include contraction of ... "Functional activity of serotoninergic and melatoninergic systems expressed in the skin". Journal of Cellular Physiology. 196 (1 ...
... and central nervous system (CNS) sensitization are key neurologic processes that appear to be involved in the induction and ... swelling in the central nervous system), nociceptive sensitisation (which causes extreme sensitivity or allodynia), vasomotor ... Central Nervous System. Idiopathic pain syndromes. Local. Complex regional pain syndrome/Reflex sympathetic dystrophy. ... It is proposed that inflammation and alteration of pain perception in the central nervous system play important roles. It has ...
The pain appears to result from processes in the central nervous system and the condition is referred to as a "central ... Yunus MB (June 2007). "Role of central sensitization in symptoms beyond muscle pain, and the evaluation of a patient with ... classed as a disorder of pain processing due to abnormalities in how pain signals are processed in the central nervous system. ... pathology due to dysfunction of muscles and connective tissue as well as functional abnormalities in the central nervous system ...
There is a strong body of evidence that the so-called sensitization of the central nervous system contributes to the emergence ... The mechanism responsible for sensitization of the central nervous system at the level of the spinal cord is different from the ... thus preventing the sensitization of the central nervous system. Another effect of naproxen is the reduction of the ... Jakubowski M, Levy D, Kainz V, Zhang XC, Kosaras B, Burstein R (2007). "Sensitization of central trigeminovascular neurons: ...
Groves and Thompson dual-process theory of habituation posits that two separate processes exist in the central nervous system ... Thus when the habituation process exceeds the sensitization process behavior shows habituation, but if the sensitization ... The Sokolov model assumes that when a stimulus is experienced several times, the nervous system creates a model of the expected ... involved with sensitization. The state system is seen as equivalent to a general state of arousal. Habituation has been ...
He used the term plasticity in reference to his work on findings of degeneration and regeneration in the central nervous system ... inducing central sensitization. For instance, individuals experiencing complex regional pain syndrome demonstrate a diminished ... New neurons are constantly produced and integrated into the central nervous system throughout the life span based on this type ... Zilles K (October 1992). "Neuronal plasticity as an adaptive property of the central nervous system". Annals of Anatomy - ...
... central nervous system effects include neuronal sensitization to tactile stimuli and mediation of some of the effects of ... The 5-HT2 receptors (of which the 5-HT2B receptor is a subtype) mediate many of the central and peripheral physiologic ... "Functional activity of serotoninergic and melatoninergic systems expressed in the skin". Journal of Cellular Physiology. 196 (1 ...
It is based on the competition of various gentle stimuli with pain transmission to the central nervous system: the so-called ... A baby's threshold for sensitization is also substantially decreased, whilst the process involves a much larger area of ... resulting in the ability of the central nervous system to inhibit nociception being more limited than in the adult. There are ... For all analgesic drugs, the immaturity of the baby's nervous system and metabolic pathways, the different way in which the ...
... activation and sensitization of the trigeminal nerve, the autonomic nervous system, and central feedbacks. There are many ...
... in which she sought to define the constraints imposed on infant visual performance by the developing central nervous system. ... "spatial sensitization," the detectability of a test light is first decreased and then increased by adding light to successively ... An interest in linking propositions can be seen in Teller's early work on spatial sensitization, which was thought to represent ...
Vella-Brincat, Jane; Macleod, A. D. (2007). "Adverse Effects of Opioids on the Central Nervous Systems of Palliative Care ... The sensitization of pronociceptive pathways in response to opioid treatment appears to involve several pathways. Research thus ... abnormal activation of NMDA receptors in the central nervous system, and long-term potentiation of synapses between nociceptive ... The pharmacology of opioids involves the substance binding to opioid receptors in the nervous system and other tissues. The ...
... which can lead to drug and neurotransmitter sensitization, central nervous system hyperexcitability, and excitotoxicity. Binge ... reduces excessive glutamate activity in the central nervous system and thereby may reduce excitotoxicity and withdrawal related ... an imbalance between inhibitory and excitatory amino acids and changes in monoamine release in the central nervous system, ... Changes in the glutamate system and GABA system may play an important role at different time points during benzodiazepine ...
... forms NO which ultimately results in vasodilatation and activation of central nervous system pain pathways. Serotonin may also ... NO plays a major role in central pain pathways and likely contributes to the process of central sensitization. Briefly, the ... these prolonged alterations in the peripheral pain pathways that lead to increased excitability of the central nervous system ... The alterations in physiology that lead to overall process of central sensitization involve changes at the level of neural ...
... moderate to severe pain due to damage to the central nervous system (CNS) which causes a sensitization of the pain system. The ... is suspected in individuals who complain of pain or other abnormal sensations following injury to the central nervous system. ... A diagnosis of central pain syndrome is based upon identification of characteristic symptoms, a detailed patient history, a ... Other conditions that cause pain may need to be excluded before a diagnosis of central pain syndrome is made. Pain medications ...
There is a strong body of evidence that the so-called sensitization of the central nervous system contributes to the emergence ... The mechanism responsible for sensitization of the central nervous system at the level of the spinal cord is different from the ... thus preventing the sensitization of the central nervous system. Another effect of naproxen is the reduction of the ... Allodynia refers to central pain sensitization (increased response of neurons) following normally non-painful, often repetitive ...
At sub-lethal doses, 1-butanol acts as a depressant of the central nervous system, similar to ethanol: one study in rats ... This is believed to be a generic effect of "defatting". No skin sensitization has been observed. Irritation of the respiratory ... The depressant effect on the central nervous system (similar to ethanol intoxication) is a potential hazard when working with 1 ...
Animal experiments have shown that, at very high concentrations, the ester has central nervous system depressant and lethal ... In rare cases exposure may cause sensitization of the mucous membrane and eruptions of the skin. The irritant effect of ethyl ... symptoms of central nervous system depression, secondary anemia and liver damage. In humans, concentrations of 400 ppm cause ...
"A fast conducting pathway in the central nervous system of the leech Hirudo medicinalis". Archives italiennes de biologie. 110 ... This has made it possible to make great progress in understanding the mechanisms of habituation and sensitization. In a series ... The nervous system of this annelid consists of a chain of interconnected ganglia that contain relatively large and easily ... Together with Franco Magni he published researches on the nervous system of the pigeon and the leech and on the hormonal ...
In the mid-1950s it was proposed that serotonin had a role as a neurotransmitter in the central nervous system (CNS) of animals ... Also they are thought to promote neurogenic inflammatory response important for sensitization of sensory afferents, and also ... Most mammalian species, including humans, have 5-HT1D binding sites widely distributed throughout the central nervous system. 5 ... but have a higher potential for central nervous side effects. Donitriptan and avitriptan were never marketed. The history of ...
Central nervous system[edit]. Rare reports have been made of malaise, dizziness, somnolence, insomnia, and vertigo. In severely ... where sensitisation occurs. Patients who take these agents develop higher levels of immunoglobulin E against food, whether they ... Pelot, Daniel, (M.D.). "Digestive System : New Drug for Heartburn". The New Book of Knowledge : Medicine & Health, Grolier : ... "The American Society of Health-System Pharmacists. Archived from the original on 2017-09-09. Retrieved Dec 1, 2015.. .mw-parser ...
They could include diseases or disorders in the central nervous system or peripheral nervous system. Examples of neuropathic ... Noxious input to the spinal cord is known to produce central sensitization, which consists of allodynia, exaggeration of pain, ... or in the central nervous system (neuropathic, neurogenic, or psychogenic). Itch originating in the skin is known as ... Neuropathic itch can originate at any point along the afferent pathway as a result of damage of the nervous system. ...
... concentrating on the effects of drugs and drug addiction on the central nervous system neurotransmitters. She has written ... CS1 maint: discouraged parameter (link)[permanent dead link] "Brain opioidergic systems and neurobehavioral sensitization in ... "brain opioidergic systems and neurobehavioral sensitization in addiction to alcohol". Sleeman, Elizabeth, ed. (2001). The ...
Mental fatigue is in the central nervous system. The remedy is to change teaching methods, e.g., use audio-visual aids, etc. ... This concept acts in direct opposition to sensitization. Sensitization is an example of non-associative learning in which the ... indicating that the central nervous system is sufficiently developed and primed for learning and memory to occur very early on ... concerns the construction and study of systems that can learn from data. For example, a machine learning system could be ...
Since CCI produces central nervous system hyperexcitability that is mediated by spinal cord NMDA and non-NMDA receptor ... This may reflect the different fibre populations involved or the greater impact of central sensitization in mechanical ... receptor-mediated central nervous system excitability that may occur following peripheral nerve injury. Both dextrorphan and ... Peripheral neuropathy is a general term that indicates any disorder of the peripheral nervous system. The name of the disorder ...
This seems to occur via immune cells interacting with the peripheral nervous system and releasing pain-producing chemicals ( ... December 2004). "Chronic oral Gabapentin reduces elements of central sensitization in human experimental Hyperalgesia". ... "Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human ... Marchand F, Perretti M, McMahon SB (July 2005). "Role of the immune system in chronic pain". Nat. Rev. Neurosci. 6 (7): 521-32 ...
... including the metabolic system, cardiovascular system, immune system, reproductive system and central nervous system. The HPA ... Heim and colleagues have proposed that early life stress, such as childhood abuse, can induce a sensitization of the HPA axis, ... At the hypothalamus, fear-signaling impulses activate both the sympathetic nervous system and the modulating systems of the HPA ... Immune system[edit]. There is bi-directional communication and feedback between the HPA axis and immune system. A number of ...
Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system» (en anglès). Nat ... Toxoplasma gondii tachyzoite-extract acts as a potent immunomodulator against allergic sensitization and airway inflammation» ( ...
... "an increased sensitivity of the central nervous system and a deeper cognitive processing of physical, social and emotional ... brain function and neuronal sensitization, and genetics.[7] For example, genetic studies provide evidence that higher levels of ... Discussion re nervous system is, inter alia, in "Prelude to Research" at p. 14. ... From "Adult shyness: ..." (2005): weak nervous system (Pavlov), low screening (Mehrabian), augmenting (of stimulation; Petrie ...
Abuse of central nervous system (CNS) stimulants is common. Addiction to some CNS stimulants can quickly lead to medical, ... Drug tolerance, dependence, and sensitization as well as a withdrawal syndrome can occur.[125] Stimulants may be screened for ... Amphetamine is a potent central nervous system (CNS) stimulant of the phenethylamine class that is approved for the treatment ... Stimulants enhance the activity of the central and peripheral nervous systems. Common effects may include increased alertness, ...
Central nervous systemEdit. Rare reports have been made of malaise, dizziness, somnolence, insomnia, and vertigo. In severely ... where sensitisation occurs. Patients who take these agents develop higher levels of immunoglobulin E against food, whether they ... Pelot, Daniel, (M.D.). "Digestive System : New Drug for Heartburn". The New Book of Knowledge : Medicine & Health, Grolier : ... "The American Society of Health-System Pharmacists. Archived from the original on 2017-09-09. Retrieved Dec 1, 2015.. .mw-parser ...
"Predicting Adaptive Behavior in the Environment from Central Nervous System Dynamics". PLoS ONE 3(11): e3678. doi:10.1371/ ... Lobster attack induces sensitization in the sea hare, Aplysia californica. J Neurosci. 2010 Aug 18;30(33):11028-31. ... Its ubiquity in synaptic plasticity studies can be attributed to its simple nervous system, consisting of just 20,000 large, ... Despite its seemingly simple nervous system, however, Aplysia californica is capable of a variety of non-associative and ...
Central nervous system. *Intracerebral. *Intrathecal. *Epidural. Circulatory,. musculoskeletal. *Intravenous. *Intracardiac. * ... They have a low risk of sensitization due to having few ingredients beyond the base oil or fat, and low irritation risk. There ... "The American Society of Health-System Pharmacists. Retrieved Sep 4, 2015.. *^ a b Wolverton, SE. Comprehensive Dermatologic ... Loyd Allen; Howard C. Ansel (23 December 2013). Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems (Tenth ed.). ...
Platt SR (2007). "The role of glutamate in central nervous system health and disease--a review". Vet. J. 173 (2): 278-86. doi: ... "Probing the role of AMPAR endocytosis and long-term depression in behavioural sensitization: relevance to treatment of brain ... and are thus responsible for most of the fast excitatory synaptic transmission in the central nervous system.[17] The AMPAR's ... is an ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system ( ...
... clinicians toward the use of myalgic encephalomyelitis on the grounds that the inflammation of the central nervous system ( ... Scientific evidence for central sensitisation in chronic fatigue syndrome". European Journal of Clinical Investigation. 42 (2 ... Tentative evidence suggests a relationship between autonomic nervous system dysfunction and diseases such as CFS, fibromyalgia ... Martinez-Martinez, Laura-Aline; Mora, Tania; Vargas; Fuentes-Iniestra; Martinez-Lavın (April 2014). "Sympathetic Nervous System ...
"Amphetamine-Type Central Nervous System Stimulants Release Norepinepehrine more Potently than they Release Dopamine and ... "The pineal gland is critical for circadian Period1 expression in the striatum and for circadian cocaine sensitization in mice ... Sigma Receptors Play Role In Cocaine-induced Suppression Of Immune System *↑ Lluch J, Rodríguez-Arias M, Aguilar MA, Miñarro J ...
This occurs because of the compromised immune system as well as the high levels of arousal in the sympathetic nervous system ... Chen, Yaniv (2009). "Advances in the pathophysiology of tension-type headache: From stress to central sensitization". Current ... This physiological stress response involves high levels of sympathetic nervous system activation, often referred to[by whom?] ... The hypothalamic-pituitary-adrenal axis and sympathetic nervous system are activated, resulting in the release of hormones from ...
Central nervous system[edit]. Further information: Neurobiological effects of physical exercise § Neuroplasticity ... the role of dopamine signaling in incentive-sensitization processes has recently been highlighted by the observation of a ... Regular aerobic exercise improves symptoms associated with a variety of central nervous system disorders and may be used as an ... The effects of physical exercise on the central nervous system are mediated in part by specific neurotrophic factor hormones ...
Index of the central nervous system. Description. *Anatomy *meninges. *cortex *association fibers ... Villégier AS, Blanc G, Glowinski J, Tassin JP (2003). "Transient behavioral sensitization to nicotine becomes long-lasting with ... "Effect of nicotine on sympathetic nervous system activity of mice subjected to immobilization stress". Physiol Behav. 55 (1): ... Nolley EP, Kelley BM (2007). "Adolescent reward system perseveration due to nicotine: studies with methylphenidate". ...
... and that the central nervous system and the kidneys are targets, with lack of motor coordination being a common sign. Similar ... Dotterud LK, Smith-Sivertsen T (2007). "Allergic contact sensitization in the general adult population: a population-based ... Risk assessment for effects on the nervous system have been made by extrapolating from dose-response relationships for ... In multidose injectable drug delivery systems, it prevents serious adverse effects such as the Staphylococcus infection that, ...
During sleep, most of the body's systems are in an anabolic state, helping to restore the immune, nervous, skeletal, and ... Obstructive sleep apnea is more common than central sleep apnea.[94] As oxygen levels in the blood drop, the patient then comes ... "Cocaine sensitization and reward are under the influence of circadian genes and rhythm". Proceedings of the National Academy ... The parasympathetic nervous system experiences increased activity during REM sleep which may cause erection of the penis or ...
Role in the central nervous system[edit]. Further information: Neurotransmitter § Brain neurotransmitter systems ... cross-sensitization Yes. Not applicable. Yes. Yes. Attenuated. Attenuated. [36] Psychostimulant. self-administration ↑. ↑. ↓. ↓ ... Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS ... Cardio-pulmonary system[edit]. In humans, the pulmonary artery expresses D1, D2, D4, and D5 and receptor subtypes, which may ...
During sleep, most of the body's systems are in an anabolic state, helping to restore the immune, nervous, skeletal, and ... Obstructive sleep apnea is more common than central sleep apnea.[103] As oxygen levels in the blood drop, the patient then ... "Cocaine sensitization and reward are under the influence of circadian genes and rhythm". Proceedings of the National Academy ... a b c d e Born, J., & Wilhelm, I. (2012). System consolidation of memory during sleep. Psychological Research, 76(2), 192-203. ...
It is one of the simplest organisms with a nervous system. The neurons do not fire action potentials, and do not express any ... These responses include acute response, tolerance, withdrawal, and sensitization.[73]. As for most model organisms, scientists ... and regulation by a central neuron". Sleep. 36 (3): 385-95. doi:10.5665/Sleep.2456. PMC 3571756. PMID 23449971.. ... White JG, Southgate E, Thomson JN, Brenner S (November 1986). "The structure of the nervous system of the nematode ...
High levels of lead in young children can impact IQ and the development of the central nervous system. The highest ... Occupational exposures associated with lung cancer, other common adverse health effects are beryllium sensitization, chronic ... Health effects include impaired development of the nervous system, thyroid problems, liver problems.[96] Environmental effects ... These effects are most damaging to children whose developing nervous systems are very susceptible to damage caused by lead, ...
... or preparation that contains any quantity of the following substances having a stimulant effect on the central nervous system, ... A cross-sensitization between MDPV and cocaine has been evidenced.[14] Furthermore, both psychostimulants, MDPV and cocaine, ... January 2019). "Neuroadaptive changes and behavioral effects after a sensitization regime of MDPV". Neuropharmacology. 144: 271 ... 8-Dihydroxyflavone blocks the development of behavioral sensitization to MDPV, but not to cocaine: Differential role of the ...
Nervous system repair: Upon injury to nerve cells within the central nervous system, astrocytes fill up the space to form a ... As noxious pain is sustained, spinal sensitization creates transcriptional changes in the neurons of the dorsal horn that lead ... Astrocytes are a sub-type of glial cells in the central nervous system. They are also known as astrocytic glial cells. Star- ... They did an experiment to attempt to repair trauma to the Central Nervous System of an adult rat by replacing the glial cells. ...
The central nervous system (CNS) perceives pain from the heart as coming from the somatic portion of the body supplied by the ... Recently this idea has regained some credibility under a new term, central sensitization. Central sensitization occurs when ... Hyperexcitability hypothesizes that referred pain has no central mechanism. However, it does say that there is one central ... Central hyperexcitability is important for the extent of referred pain.[1]. *Patients with chronic musculoskeletal pains have ...
Neuropathic pain[14] is divided into "peripheral" (originating in the peripheral nervous system) and "central" (originating in ... the somatotopic representation of the body is inappropriately reorganized following peripheral and central sensitization. This ... The nervous system and the heart. Totowa, New Jersey: Humana Press. p. 304. ISBN 978-0-89603-693-2.. ... Chronic neuropathic pain: pain caused by damage to the somatosensory nervous system damage. ...
However, it has been proposed that only when the UR does not involve the central nervous system are the CR and the UR opposites ... An organism's need to predict future events is central to modern theories of conditioning. Most theories use associations ... especially in maintaining the caste system upon which society is based. Another example is in Anthony Burgess' 1962 dystopian ... is a specific form of Pavlovian-related motivation for rewards mediated by mesocorticolimbic brain systems ...Incentive ...
During maturation of the nervous system, the expression of N or L-type currents becomes more prominent. As a result, mature ... The α2δ subunit is also a binding site of the central depressant and anxiolytic drug phenibut, in addition to actions at other ... A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+ sensitization: Rho- ... ISBN 0-8153-3218-1. Sanes, Dan H.; Reh, Thomas A (2012). Development of the nervous system (Third ed.). Elsevier Academic Press ...
... s are one of three classes of nerve fiber in the central nervous system (CNS) and peripheral nervous system ... Central sensitization[edit]. After nerve damage or repeated stimulation, WDR (wide dynamic range) neurons experience a general ... conveying input signals from the periphery to the central nervous system.[2] ... C fibers cause central sensitization of the dorsal horn in the spinal cord in response to their hyperactivity.[5] The mechanism ...
... may result from disorders of the peripheral nervous system or the central nervous system (brain and spinal ... Central sensitization[edit]. Central sensitization is a potential component of neuropathic pain. It refers to a change in ... Certain forms of neuropathic pain are associated with lesions to the central nervous system such as thalamic pain associated ... "Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity". The Journal of Pain. 10 (9): 895-926 ...
Throughout the brain and peripheral nervous system. R-type calcium channel ("Residual"). intermediate voltage activated. Cav2.3 ... The α2δ subunit is also a binding site of the central depressant and anxiolytic drug phenibut, in addition to actions at other ... A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+ sensitization: Rho- ... During maturation of the nervous system, the expression of N or L-type currents becomes more prominent.[15] As a result, mature ...
CNS, central nervous system; ANS, autonomic nervous system; PS, peripheral sensitization; CS central sensitization; SP, ... systems throughout the central (upper neuron) and peripheral (lower neuron) nervous system. The "somatic" system is composed by ... John N. Langley coined the terms "autonomic nervous system" and "parasympathetic nervous system" about the turn of the ... the parasympathetic cholinergic system, the sympathetic adrenergic system, and the enteric nervous system (see Goldstein, 2001 ...
... central nervous system depression; skin sensitization ...
Eyes, skin, respiratory system, central nervous system, blood Personal Protection/Sanitation. (See protection codes) Skin: ... skin sensitization ... irritation eyes, skin, respiratory system; cough; dizziness, ...
... central nervous system; skin sensitization; skin, eye and respiratory tract irritation; acute toxicity effects; and ... For the purpose of this subsection, reaction vessels, storage tanks, and pipes or piping systems are not considered to be ... c) The details of the hazard communication program developed by the employer, including an explanation of the labeling system ... iv) The details of the hazard communication program developed by the employer, including an explanation of the labeling system ...
Background Central sensitization is an important mechanism of chronic migraine (CM) and is related to the inflammatory response ... Considerable evidence from animal models of neuroinflammation suggests that IL-1β of the central nervous system (CNS) is mainly ... Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009;10:895-926.CrossRef ... Central sensitization is an important mechanism of chronic migraine (CM) and is related to the inflammatory response of ...
... central nervous system depression; skin sensitization Target Organs Eyes, skin, respiratory system, central nervous system ...
The substance may have effects on the kidneys, central nervous system and peripheral nervous system. This may result in ataxia ... MAK: (as Hg, inhalable fraction): 0.02 mg/m3; peak limitation category: II(8); skin absorption (H); sensitization of skin (SH ... May cause damage to nervous system and kidneys through prolonged or repeated exposure. Very toxic to aquatic life with long ... Repeated or prolonged contact may cause skin sensitization. ...
The substance may have effects on the respiratory tract, gastrointestinal tract, central nervous system and liver. This may ... Repeated or prolonged contact may cause skin sensitization. ...
May cause central nervous system effects. This substance has caused adverse reproductive and foetal effects in animals. ... May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Causes skin ... May cause central nervous system effects including vertigo, anxiety, depression, muscle incoordination, and emotional ... Target Organs: Blood, kidneys, central nervous system, liver, brain. Potential Health Effects Eye: Exposure to mercury or ...
We searched the related article on PubMed database and Cochrane database to discover central sensitization pathway in ... These mechanisms of acupuncture analgesia may be involved in the alleviation of central sensitization. ... thus modifying central sensitization. The possible mechanisms underlying the analgesic effects of acupuncture include segmental ... Pain can trigger central amplification called central sensitization, which ultimately results in hyperalgesia and/or allodynia ...
Central Nervous System Sensitization / drug effects * Cyclophosphamide / administration & dosage * Disease Models, Animal ... 1 Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, ... 2 Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, ... 7 Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, ...
The overexcitement of neurons in the central nervous system is central sensitization and can occur with any type of pain.) This ... The way the central nervous system processes and transmits pain-related information can be influenced by a number of genetic ... Neuropathic pain, a disease of the peripheral or central nervous system that arises when a persons nerves, spinal cord, or ... Research has now established that pain can cause biological changes in the peripheral and central nervous systems, as described ...
Central Nervous System Sensitization. An increased response to stimulation that is mediated by amplification of signaling in ... Unusual relapse of primary central nervous system lymphoma both inside and outside central nervous system in a patient with ... Relapse of primary central nervous system lymphoma (PCNSL) occurs primarily at the initial site, relapse outside central ... Hereditary Central Nervous System Demyelinating Diseases. Inherited conditions characterized by a loss of myelin in the central ...
Ive been told I have pain sensitization, which is a polite way of saying you have a damaged central nervous system. What do ... Perhaps even become an immune reaction to ones own nervous system? A Hypersensized response or Central sensitization?? Do you ... Nice set up they have going, eh? I dont know how common this is for patients with central type pain syndromes to get told to ... know anywhere/or anyone on the boards here who could input in this area? Is it normal for people with Central pain (CNS) to ...
Central sensitization: Increased excitability of central nervous system xi . xii GLOSSARY (CNS) neurons and consequent ... Neuraxis: The central nervous system (CNS; the spinal cord and the brain). Nociception: The detection of a noxious event by ... Nocicep- tion represents the peripheral and central nervous system processing of information about the internal or external ... Increased sensitivity and response to a noxious stimulus enhanced by sensitization of peripheral nociceptors and central ...
Neurons contain opioid receptors that transmit antipain reactions in the peripheral and central nervous system. Proinflammatory ... Opioid receptors mediate antipain responses in both the peripheral and central nervous systems, and RANTES/CCL5 is able to ... this results in central sensitization [19]. Moreover, immune activation near or around the peripheral nerves can cause ... and diseases of the central nervous system, such as multiple sclerosis [23]. RANTES has also been associated with the induction ...
... investigators have coupled toxins to neuropeptides for the purpose of lesioning specific neurons in the central nervous system ... Furthermore, these results demonstrate that SP-CTA can be used as a tool to study sensitization of central neurons in vivo in ... Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin.. [Robert M Caudle, Andrew J ... sensitivity is suppressed suggesting that descending inhibitory pathways may be activated by the SP-CTA induced sensitization ...
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the central nervous system, ... Causes damage to the nervous system and the kidneys through prolonged or repeated exposure. Very toxic to aquatic life with ... peripheral nervous system and kidneys. This may result in ataxia, sensory and memory disturbances, tremors, muscle weakness and ... MAK: (as Hg, inhalable fraction): 0.02 mg/m3; peak limitation category: II(8); skin absorption (H); sensitization of skin (SH ...
The substance may have effects on the kidneys, central nervous system and peripheral nervous system. This may result in ataxia ... Repeated or prolonged contact may cause skin sensitization. ... May cause damage to nervous system and kidneys through ...
Irritation eyes: conjunctivitis; keratitis (inflammation of the cornea); central nervous system excitement; colored urine, ... nausea, dizziness, suffocation, rapid breathing; muscle twitching, delirium; collapse; skin irritation, sensitization, ... Eyes, skin, respiratory system, central nervous system NIOSH MX3500000. ROS inhibitor TargetMol T0673. ...
Central nervous system. *fatigue. *headache. *lethargy. Ear, Eye, Nose, Throat. *rhinorrhea. Respiratory. *cough ... Use Cautiously in: Known allergies to horse protein (↑ risk of serious hypersensitivity reactions); sensitization may develop ...
Inhalation: Manganese compounds can cause irreversible damage to the central nervous system upon. prolonged exposure through ... May cause sensitisation.. Eye contact: May cause eye irritation.. Ingestion : none known.. 4.3 Indication of any immediate ... Treat in accordance with skin, eye irritation and sensitisation procedures.. Fire-fighting measures. 5.1 Extinguishing media. ...
Repeated exposure causes skin sensitization and may cause central nervous system and liver damage.[7] ... Acrylonitrile - Integrated Risk Information System, U.S. Environmental Protection Agency. *CDC - NIOSH Pocket Guide to Chemical ...
Central nervous system effects of damage to visceral tissues in humans. Drewes, A. M., 9 Aug 2018, Pain after surgery. Carr, D ... Central sensitization in humans: assessment and pharmacology. Arendt-Nielsen, L., 2015, Pain Control. Schaible, H-G. (ed.). ... Andersen, H. H. & Gazerani, P., 2016, Mapping of Nervous System Diseases via MicroRNAs. Barbato, C. & Ruberti, F. (eds.). CRC ... Online adaptive synchronous BCI system with attention variations. Hosseinabadi, S. A., Kamavuako, E. N., Jiang, N., Farino, D ...
Assessment and manifestation of central sensitisation across different chronic pain conditions. Arendt-Nielsen, L., Morlion, B ... Gervasio, S., Laursen, C. B., Andersen, O. K., Hennings, K. & Spaich, E. G., May 2018, In: IEEE Transactions on Neural Systems ... Patel, G. K., Castellini, C., Hahne, J. M., Farina, D. & Dosen, S., 1 Sep 2018, In: IEEE Transactions on Neural Systems and ... 2017 Intelligent Systems Conference, IntelliSys 2017, Vol. 2018-January).. Research output: Contribution to book/anthology/ ...
Influence of the Gut Microbiome on Autoimmunity in the Central Nervous System. Sara L. Colpitts and Lloyd H. Kasper. J Immunol ... The Influence of the Microbiome on Allergic Sensitization to Food. Catherine H. Plunkett and Cathryn R. Nagler. J Immunol 2017 ... NK Cells in Central Nervous System Disorders. Aurelie Poli, Justyna Kmiecik, Olivia Domingues, Francois Hentges, Mathieu Blery ... Stromal Cell Niches in the Inflamed Central Nervous System. Natalia B. Pikor, Jovana Cupovic, Lucas Onder, Jennifer L. ...
Neuropathic Pain Pain Pathophysiology Nociceptive pain Neuropathic pain Nociceptive Pain Sensitization and activation of ... Peripheral sensitization. Healthy nociceptors. Abnormal nociceptors. CNS. CNS central nervous system Central sensitization ... central sensitization and then reorganization of the pain pathways at the dorsal horn level ... Indicative of CNS sensitization 20. Diagnostic Workup Lab Tests*Complete blood cell count with differential, erythrocyte ...
Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system. Hua ZL, Jeon S, Caterina ... Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain. Kim YS, Chu Y, Han L, ... By examining these channels in recombinant and native systems, and taking advantage of knockout mice lacking one or more ... The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved. ...
Definition: A long term increased excitability of second and/or third order neurons in the central nervous system. ... central sensitization. It is now thought that central sensitization is an important mechanism in the pain experience of ... Its pathogenesis is now understood to involve long lasting changes in the central nervous system referred to as neural ... In other words the nervous system is not hard wired. The first demonstration of neural plasticity was in 1965 (70). Mendell ...
Abuse of central nervous system (CNS) stimulants is common. Addiction to some CNS stimulants can quickly lead to medical, ... Drug tolerance, dependence, and sensitization as well as a withdrawal syndrome can occur. Stimulants may be screened for in ... Avois, L; Robinson, N; Saudan, C; Baume, N; Mangin, P; Saugy, M (7 January 2017). "Central nervous system stimulants and sport ... Amphetamine is a potent central nervous system (CNS) stimulant of the phenethylamine class that is approved for the treatment ...
  • Therefore, central sensitization is due to a nociceptive input that results in a persistent increase in the excitability and synaptic effect of neurons in the nociceptive pathways of the CNS, and this phenomenon maintains a persistent state of heightened reactivity [ 4 ]. (hindawi.com)
  • The lamina I and lamina V neurons of the spinal cord as well as the thalamus, amygdala, and anterior cingulate cortex are involved in central sensitization [ 6 ]. (hindawi.com)
  • Therefore, central sensitization is due to a persistent state of high reactivity of nociceptive afferent neurons in the CNS. (hindawi.com)
  • Neurons contain opioid receptors that transmit antipain reactions in the peripheral and central nervous system. (hindawi.com)
  • Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin. (sigmaaldrich.com)
  • Several investigators have coupled toxins to neuropeptides for the purpose of lesioning specific neurons in the central nervous system. (sigmaaldrich.com)
  • At higher doses (10 microg) peripheral sensitivity is suppressed suggesting that descending inhibitory pathways may be activated by the SP-CTA induced sensitization of spinal cord neurons. (sigmaaldrich.com)
  • Furthermore, these results demonstrate that SP-CTA can be used as a tool to study sensitization of central neurons in vivo in the absence of an injury. (sigmaaldrich.com)
  • This is the system made up of sensory receptors and neurons (nerve cells) in the central nervous system and the peripheral nervous system (outside of the central nervous system). (clevelandclinic.org)
  • Dopamine neurons originating in the midbrain ventral tegmental area and projecting to various forebrain nuclei, including the nucleus accumbens, are part of the mesolimbic dopamine system. (jneurosci.org)
  • Once the central nervous system is involved, persistent pain leads to long-term or permanent changes in these neurons, which affect adjacent neurons through neurotransmitters. (positivehealth.com)
  • The recent concept of chronic pain is the sensitization of spinal nociceptive neurons, with or without the original provoking stimuli . (omicsonline.org)
  • The central melanocortin system comprises neurons that produce endogenous melanocortins and the downstream neurons that express melanocortin receptors. (pubmedcentralcanada.ca)
  • Boal & Gillette hypothesized that SMT relieves chronic low back pain by its afferent, peripheral nervous system input inhibiting or altering neuroplastic changes occurring in spinal cord dorsal horn neurons involved in transmitting or amplifying pain signals. (acatoday.org)
  • Central sensitization is defined as "an amplification of neural signaling within the central nervous system (CNS) that elicits pain hypersensitivity" [ 4 ]. (hindawi.com)
  • In a controlled clinical trial of skin sensitization, 1 of 200 patients (0.5%) demonstrated skin hypersensitivity to Gelnique. (drugs.com)
  • If original pain is not treated completely, the repeat pain signals lead to change in the central nervous system becomes hypersensitivity. (omicsonline.org)
  • Evidence for a central component of post-injury pain hypersensitivity. (nih.gov)
  • Because sensitization of peripheral receptors occurs following injury, a peripheral mechanism is widely held to be responsible for post-injury hypersensitivity. (nih.gov)
  • 3-5 Central sensitization results in amplified neural signaling within the central nervous system causing pain hypersensitivity. (acatoday.org)
  • Repeated or prolonged contact may cause skin sensitization. (ilo.org)
  • It may also cause skin sensitization. (naturalpedia.com)
  • We argue that this will provide a foundation to create the ground for future research focusing on the hypotheses that manual therapies, specifically osteopathy, can intercede with sensitization states, at all levels, using interoceptive pathways. (frontiersin.org)
  • An interesting property of these dopamine pathways is cross-sensitization. (jneurosci.org)
  • The difficult-to-treat problem of phantom limb pain is consciously actualized by persistent activation (sensitization) of the pain transmission pathways from the site of amputation up to the brain. (erikdalton.com)
  • That is, an excess of "feel good" signals from serotonin could cancel out the pain signals transmitted by Substance P. But when the two pathways malfunction simultaneously, the unfortunate owner of that nervous system feels very poorly indeed. (fmaware.org)
  • They also may have reduced spinal fluid levels of neurotransmitters such as norepinephrine and serotonin that are involved in the pain inhibitory pathways in the central nervous system. (healthywomen.org)
  • Nociceptors then relay information to the central nervous system, indicating the location, nature and intensity of the ensuing pain. (neurosciencenews.com)
  • This could result from either a reduction in the thresholds of skin nociceptors (sensitization) or an increase in the excitability of the central nervous system so that normal inputs now evoke exaggerated responses. (nih.gov)
  • Interestingly, if the underpinning mechanisms of a given treatment scenario/effect are taking into account, the majority of research outcomes focuses on a proprioceptive/exteroceptive explanation, leaving ting aside the additional or even central role of interoception. (frontiersin.org)
  • Currently, to date, the application of theoretical knowledge acquired on the relatively recent neuroscientific concepts and evidence concerning of interoception, sensitization, touch, autonomic functions, inflammation, and pain into a clinical/research manual medicine scenario is lacking, even if theoretically, the impact on the possible etiological mechanisms and treatment effects seems to be important. (frontiersin.org)
  • These mechanisms of acupuncture analgesia may be involved in the alleviation of central sensitization. (hindawi.com)
  • This study was set to explore the therapeutic effects and the mechanisms of treadmill exercise on a time-dependent sensitization (TDS) model which is a classical animal model for mimicking posttraumatic stress disorder (PTSD). (minervamedica.it)
  • The underlying mechanisms of pain chronicization after an acute pain episode involve both peripheral and central nervous system sensitization. (springer.com)
  • It is well appreciated that distinct sensory mechanisms contribute to physiological pain, to pain arising from tissue damage (inflammatory or nociceptive pain), and to pain arising from injury to the nervous system (neuropathic pain). (aspetjournals.org)
  • Musculoskeletal pain in relation to central and peripheral pain mechanisms, the immune system and affective aspects of pain, see box 1 for summary. (bmj.com)
  • A process called sensitization has become a topic of great interest to neuroscientists studying transmission mechanisms of painful stimuli. (erikdalton.com)
  • Does Spinal Manipulation Affect Central Nervous System Pain Mechanisms? (acatoday.org)
  • information from sensory receptors to the central nervous system (CNS) is what nerve? (studystack.com)
  • In particular, central nervous system plasticity of glutamatergic signaling involving NMDA and metabotropic glutamate receptors (mGluRs) has been implicated in a variety of chronic pain conditions. (nih.gov)
  • 13. Blackshaw LA, Page AJ , Smid S, Dent J, and Lehmann A. GABAB receptors - peripheral and central targets for controlling gastro-oesophageal reflux. (edu.au)
  • Magnesium blocks sensitization in the central nervous system through its effect on N-methyl-D-aspartate receptors. (thefreelibrary.com)
  • Furthermore, activation of P2Y 2 receptors leads to sensitization of polymodal transient receptor potential-1 receptors. (aspetjournals.org)
  • Current evidence indicates that central melanocortins also regulate insulin sensitivity and glucose homeostasis through distinct CNS populations expressing melanocortin receptors. (pubmedcentralcanada.ca)
  • Central Sensitization in Functional Chronic Pain Syndromes: Overview and Clinical Application. (semanticscholar.org)
  • Selective antagonists for the P2X 7 receptor also reduce sensitization in animal models of inflammatory and neuropathic pain, providing evidence that purinergic glial-neural interactions are important modulators of noxious sensory neurotransmission. (aspetjournals.org)
  • Treat in accordance with skin, eye irritation and sensitisation procedures. (europa.eu)
  • Comment: Persistent mechanical irritation of the nerve root (as seen with degenerated or herniated discs) sets up a series of events that lead to chronic pain, mediated by sensitization of the dorsal roots and dorsal horns in the spinal cord. (thefreelibrary.com)
  • Clinical signs of toxicity associated with human exposure to large quantities of 1,1,1-trichloroethane include central nervous system depression, hypotension, cardiac arrhythmia, diarrhea and vomiting, mild hepatic effects, and dermal and ocular irritation. (cdc.gov)
  • Sensitization is defined as the neurologically-based amplification response produced by repeated stimuli. (frontiersin.org)
  • Pain sensitization is the body developing an overt response to noxious stimuli. (dailystrength.org)
  • The segmental sensitization consists of the nociceptive stimuli in the sensitized areas with sending the sensitization signal to bombard the dorsal horn in the spinal cord. (omicsonline.org)
  • In fibromyalgia the nerves of the brain and spinal cord are too sensitive to stimuli, a condition called "central sensitization. (fmaware.org)
  • The long-term consequences of noxious stimuli result, therefore, from central as well as from peripheral changes. (nih.gov)
  • Pain can trigger central amplification called central sensitization, which ultimately results in hyperalgesia and/or allodynia. (hindawi.com)
  • Hyperalgesia (increased pain sensitivity) and allodynia (pain production induced by a nonnociceptive stimulation) are the two main characteristics of central sensitization [ 5 ]. (hindawi.com)
  • Cutaneous allodynia (CA) in migraine is a clinical manifestation of central nervous system sensitization. (fightingfatigue.org)
  • Inhalation of vapors or mists may cause central nervous system depression, light-headedness, headache, nausea and loss of coordination. (nih.gov)
  • Deaths of persons exposed to high concentrations have been attributed to cardiac arrhythmia and respiratory failure secondary to central nervous system depression. (cdc.gov)
  • A patient who ingested 500 milliliters of Hexastar (5.5 percent EC) experienced central nervous system depression and generalized trembling. (naturalpedia.com)
  • Both depression and fibromyalgia involve problems with the neurotransmitters in the central nervous system. (fmaware.org)
  • Disorders of the glands of the endocrine system, such as the thyroid, pancreas, and adrenals, can lead to neurotransmitter dysregulation and depression. (fmaware.org)
  • To further examine the effects of the NLRP3 inflammasome pathway on central sensitization of CM, we examined MCC950, an NLRP3 inflammasome-specific inhibitor, and IL-1ra, an IL-1β antagonist, whether altered NTG-induced mechanical hyperalgesia of the periorbital area and hind paw. (springer.com)
  • We searched the related article on PubMed database and Cochrane database to discover central sensitization pathway in acupuncture analgesia. (hindawi.com)
  • When pain signals are transmitted from injured or diseased tissues, these signals can then activate (sensitize) pain circuits in the peripheral nervous system, spinal cord and brain by burning a memory pathway. (erikdalton.com)
  • There is evidence suggesting RLs is a primary pain modulation disorder involving central sensitization at the spinal cord level. (aafp.org)
  • peripheral or structural reasoning if the clinical picture forces us to reason at musculoskeletal level (history of recent trauma or overuse) but at the same time raised awareness of possible contemporary central modulation which takes us away from searching a peripheral driver). (imta.ch)
  • Arguably, this mindset lacks an appropriate "reading system" able to interpret musculoskeletal disorders from a different perspective, where the properties of the nervous system are embraced into a more holistic and functional-related context. (frontiersin.org)
  • There are many factors that can contribute to chronic pelvic pain - gynaecological, musculoskeletal, bowel/bladder, vaginal/vulvar, psychosocial, and central nervous system sensitization. (bcwomens.ca)
  • Some pelvic pain can occur as a result of several things, such as musculoskeletal factors and central nervous system sensitization, and may require other types of treatment instead of, or in addition to surgery. (bcwomens.ca)
  • One of the first and probably main difficulties in trying to identify neuro-musculoskeletal drivers of lateral elbow pain is the fact that central sensitization is suggested to be involved in lateral elbow pain (1,5,6,7,8,9,11,13,14,17). (imta.ch)
  • Introduction Osteoarthritis (OA) is a highly prevalent painful condition of the musculoskeletal system. (bmj.com)
  • To date, evidence consistently highlights that several subgroup of patients, with or without pain-related syndromes, exhibit a documented sensitization (Table 1 ). (frontiersin.org)
  • Central pain augmentation resulting from enhanced excitatory and/or decreased inhibitory neurotransmission is a proposed mechanism underlying the pathophysiology of functional pain syndromes such as fibromyalgia (FM). (fightingfatigue.org)
  • In its vicious cycle, a pain stimulus itself can trigger the central amplification of pain, called central sensitization, and ultimately cause hyperalgesia [ 2 ]. (hindawi.com)
  • Central sensitization is due to an enhanced response of the CNS, which causes the development of hyperalgesia [ 5 ]. (hindawi.com)
  • The clinical presentation of dorsal horn sensitization is including dermatomal hyperalgesia , sclerotome pressure pain sensitivity and myotome myofascial trigger points, which are all supplied by the sensitized spinal segment. (omicsonline.org)
  • This causes central nervous system sensitization with resulting of dermatomal and sclerotome hyperalgesia and spreading from the sensory component of the spinal segment to the anterior horn cells, which control the myotome resulting of myotome myofascial trigger points within the territory of the segmental sensitization [ 5 - 10 ]. (omicsonline.org)
  • This sensitization causes a state of "hyperalgesia," or increased sensitivity to pain. (neurosciencenews.com)
  • Inhalation: Manganese compounds can cause irreversible damage to the central nervous system upon prolonged exposure through inhalation. (europa.eu)
  • Prolonged or repeated inhalation exposure may produce signs of central nervous system involvement, particularly dizziness and jerking eye movements. (nih.gov)
  • In lab tests, hexaconazole exposure may result in central nervous system breakdown. (naturalpedia.com)
  • The substance may have effects on the kidneys, central nervous system and peripheral nervous system. (ilo.org)
  • Circulating exotoxin causes the systemic symptoms of diphtheria, most profoundly affecting the nervous system, heart, and kidneys. (tripdatabase.com)
  • Here, we propose the conceptual foundations for a new way of interpreting and reading patients' clinical reported outcomes scenario based on interoception and sensitization. (frontiersin.org)
  • Several Phase II and III clinical trials have demonstrated that immunotherapy can induce objective responses in otherwise refractory malignancies in tumors outside the central nervous system. (bioportfolio.com)
  • According to the Institute for Clinical Systems Improvement, chronic pain can be grouped into four main types. (clevelandclinic.org)
  • Institute for Clinical Systems Improvement. (clevelandclinic.org)
  • Because of its clinical significance, a variety of sensory testing methods have been developed to indirectly assess observable signs of central sensitization (Table 1). (acatoday.org)
  • Temporal summation of pain is an indirect clinical and experimental measure of central sensitization. (acatoday.org)
  • We summarized that acupuncture enhances the descending inhibitory effect and modulates the feeling of pain, thus modifying central sensitization. (hindawi.com)
  • Altered membrane excitability, reduced inhibitory transmission, and increased synaptic efficacy contribute to the development of central sensitization. (hindawi.com)
  • Once the central nervous system has become hypersensitive to pain, it is difficult to reverse the hyperactivity and the associated persistent pain. (clevelandclinic.org)
  • The recently understanding of 'central sensitization" is as if initial pain from an injury is not adequately treated, those pain signals are repeatedly sent, which leads to changes in the central nervous system, making it hypersensitive. (omicsonline.org)
  • Sensitization of spinal segments is the main cause of continuous hypersensitive pain in the associated part of the body. (omicsonline.org)
  • Long-term changes occur within the peripheral and central nervous systems following noxious input. (powershow.com)
  • NMDA sensitization and stimulation by peroxynitrite, nitric oxide, and organic solvents as the mechanism of chemical sensitivity in multiple chemical sensitivity. (ei-resource.org)
  • an over-reaction of the central nervous system to stimulation. (healthcentral.com)
  • The condition can also be called "central sensitization" "central amplification" and "central pain syndrome. (arthritis.org)
  • Referred pain is often accompanied by local skin or deep tenderness, and by such reflex phenomena as reactive hyperemia11, a visible manifestation of the central excitatory state analogous to the "windup" phenomena. (prohealth.com)
  • Barili P, De Carolis G, Zaccheo D, Amenta F. Sensitivity to ageing of the limbic dopaminergic system: a review. (springer.com)
  • Glutamate and GABA are involved in controlling the general sensitivity of the nervous system, and are beginning to be recognized as important in FM. (fmaware.org)
  • In addition, we will discuss distinct neuronal populations that respond to central melanocortins to regulate food intake, energy expenditure, insulin sensitivity, and insulin secretion, respectively. (pubmedcentralcanada.ca)
  • One of the main sites of interaction of the immune system with persistent pain has been identified as neuro-immune crosstalk at the glial-opioid interface. (nih.gov)
  • Mechanical quantitative sensory testing (QST) assesses sensory functioning and detects functional changes in (central) nociceptive processing. (chiro.org)
  • Quantitative sensory testing is widely used in human research to investigate the state of the peripheral and central nervous system contributions in pain processing. (clinicaltrials.gov)
  • Central nervous system reorganization in a variety of chronic pain states: a review. (semanticscholar.org)
  • Repeated and prolonged occupational overexposure to solvent vapor may cause permanent brain and nervous system damage, and may cause liver or kidney damage. (nih.gov)
  • Pain is always produced by the brain and nervous system, regardless of where you feel it. (bcwomens.ca)
  • The nervous system is made up of two main systems, the central nervous system (brain and spinal cord) and the peripheral nervous system (all the nerves in the rest of the body). (fmaware.org)
  • First used to describe pain that occurs after a brain, brainstem or spinal cord injury, centralized pain now describes any pain that happens when the central nervous system doesn't process pain signals properly. (arthritis.org)
  • Consistent with the influence of these efflux pumps on central nervous system drug distribution, Mdr1a/b −/− Bcrp1 −/− knockout mice had a significantly higher brain to plasma ratio for rucaparib (1.61 ± 0.25) than wild-type mice (0.11 ± 0.08). (aacrjournals.org)
  • While numerous molecules in the brain and neural structures play key roles in regulating energy and glucose balance and deserve attention, the current review will focus on the central melanocortin system. (pubmedcentralcanada.ca)
  • The investigators were particularly interested in the phenomenon of central sensitization, in which the central nervous system -- including the brain and spinal cord -- amplifies painful sensations. (eurekalert.org)
  • Now the pain is driven by dysfunction in the central nervous system (CNS). (arthritis.org)
  • Most drugs classified as stimulants are sympathomimetics, that is they stimulate the sympathetic branch of the autonomic nervous system. (wikipedia.org)
  • The substance may have effects on the respiratory tract, gastrointestinal tract, central nervous system and liver. (ilo.org)
  • Sometimes after a disease or injury occurs, the central and peripheral nervous systems undergo abnormal changes in their structure and function. (clevelandclinic.org)
  • Butler 3-4 and Shacklock 5 have their own systems for addressing peripheral nerve tension. (dynamicchiropractic.com)
  • It is a useful system: basically applying a variant of myofascial release directly over the fascia surrounding the nerve. (dynamicchiropractic.com)
  • The first reference is an overview of Lyftogt's view of chronic pain, as central sensitization versus peripheral nerve issues. (dynamicchiropractic.com)
  • One interesting new area of pain management research that is gaining a great deal of attention proposes alternative ways that nerve impulses are transmitted and learned by the central nervous system. (erikdalton.com)
  • Desensitization of the segment consists of local injection with anaesthetic agents for blocking posterior branch of the dorsal spinal nerve along the related paraspinal muscles, together with local anaesthetic injection directly to the trigger points, Extracorporeal Shock Wave Therapy (ESWT) and High intensity laser therapy for desensitization of trigger point foci and area of sensitization. (omicsonline.org)
  • When pain is prolonged, even just for days, there is a maladaptive response: damage to the central nervous system, particularly to the sympathetic nervous system and the hypothalamus-pituitary-adrenal (HPA) systems, called central sensitization. (positivehealth.com)
  • Pain sensitization can be healed once the original injury repairs, once the precipitating factor goes away. (dailystrength.org)
  • This is thought to reflect enhanced pain processing that is characteristic of central pain sensitization. (healthywomen.org)
  • Barral has a whole system of manual therapy to the peripheral nerves. (dynamicchiropractic.com)
  • There is also the concept of 'central sensitizatin'- i.e . the nerves in the spinal cord may grow/ become increasingly sensitive to pain that is experienecd over and over. (dailystrength.org)
  • It can arise not only from pathology affecting any of the structures located within the pelvis and lower abdomen, but also related areas such as the skeletal system, nerves or muscles. (bpac.org.nz)
  • As such, injury-induced sensitization of peripheral nerves facilitates a sensitization of the central nervous system. (aspetjournals.org)
  • This process contributes to the central sensitization observed in CM. (springer.com)
  • The etiology is unknown, however evidence suggests that nervous system sensitization contributes to enhanced pain in IC/PBS. (nih.gov)
  • Regulation of lymphocyte trafficking in central nervous system autoimmunity. (bioportfolio.com)
  • CD4 T helper (Th) cells play a central role in orchestrating protective immunity but also in autoimmunity. (bioportfolio.com)
  • Here we show that PMN-MDSCs can restrain B cell accumulation during central nervous system (CNS) autoimmunity. (nature.com)
  • Studies have suggested that manipulations of the central melanocortin circuitry by pharmacological agents produce robust effects on the regulation of body weight and glucose homeostasis. (pubmedcentralcanada.ca)
  • As illustrated below, the physiological significance of the central melanocortin system has gone beyond the regulation of feeding and body weight. (pubmedcentralcanada.ca)
  • Recent evidence suggests that preoperative regional administration of local anesthetics can preempt postoperative pain by preventing the establishment of central sensitization. (powershow.com)
  • We will also review evidence supporting the role of the melanocortin system as the key mediator for multiple metabolic cues, such as leptin, estrogens, and serotonin. (pubmedcentralcanada.ca)
  • The cause of fibromyalgia is unknown, but recent evidence suggests it is associated with abnormalities in the central nervous system processing of pain. (healthywomen.org)
  • Both are diseases of the nervous system involving dysregulation of some of the same neurotransmitters. (fmaware.org)
  • Sensitization in patients with painful knee osteoarthritis. (springer.com)
  • Even things that do not tend to hurt become painful for people with central sensitization. (hhnmag.com)
  • Salvinorin A, a neoclerodane diterpene isolated from Salvia divinorum , exerts a number of pharmacological actions which are not solely limited to the central nervous system. (frontiersin.org)
  • Our study demonstrates that Salvinorin A inhibits airway hyperreactivity induced by sensitization by inhibition of LT production and mast cell degranulation. (frontiersin.org)
  • Chemicals called norepinephrine and serotonin play a role in the body's pain-inhibition system. (arthritis.org)
  • Philip Mease suggests: "A unifying hypothesis is that FM results from sensitization of the central nervous system. (prohealth.com)
  • 14. Page AJ, O'Donnell T & Blackshaw LA. P 2X receptor-induced sensitization of vagal mechanoreceptors in oesophageal inflammation. (edu.au)
  • Conditions associated with chronic inflammation cause central nervous system sensitization, leading to a vicious cycle of pain. (positivehealth.com)
  • It is proposed that inflammation and alteration of pain perception in the central nervous system play important roles. (wikipedia.org)
  • Since LTs are potent lipid mediators implicated in allergic diseases, we evaluated the effect of Salvinorin A on allergic inflammation and on airways following sensitization in the mouse. (frontiersin.org)
  • Below the surface of acute bacterial or viral infections lie chronic inflammations, the products of an immune system that is being constantly triggered by overexpressed cytokines. (hindawi.com)
  • 3 The progression of acute pain to chronic pain, and the maintenance of chronic pain, are thought to be due, in part, to central sensitization. (acatoday.org)
  • Anatomical representations of single anatomical structures in the central nervous system are poorly represented if at all (4). (imta.ch)
  • Central sensitization is a physiological process underlying many chronic pain conditions, including low back pain. (acatoday.org)