Central Nervous System Sensitization: An increased response to stimulation that is mediated by amplification of signaling in the CENTRAL NERVOUS SYSTEM (CNS).Central Nervous System: The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.Central Nervous System Diseases: Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.Manipulation, Spinal: Adjustment and manipulation of the vertebral column.Manipulation, Osteopathic: Musculoskeletal manipulation based on the principles of OSTEOPATHIC MEDICINE developed in 1874 by Dr Andrew Taylor Still.Manipulation, Orthopedic: The planned and carefully managed manual movement of the musculoskeletal system, extremities, and spine to produce increased motion. The term is sometimes used to denote a precise sequence of movements of a joint to determine the presence of disease or to reduce a dislocation. In the case of fractures, orthopedic manipulation can produce better position and alignment of the fracture. (From Blauvelt & Nelson, A Manual of Orthopaedic Terminology, 5th ed, p264)Musculoskeletal Manipulations: Various manipulations of body tissues, muscles and bones by hands or equipment to improve health and circulation, relieve fatigue, promote healing.Pleasure: Sensation of enjoyment or gratification.Sensation: The process in which specialized SENSORY RECEPTOR CELLS transduce peripheral stimuli (physical or chemical) into NERVE IMPULSES which are then transmitted to the various sensory centers in the CENTRAL NERVOUS SYSTEM.Awareness: The act of "taking account" of an object or state of affairs. It does not imply assessment of, nor attention to the qualities or nature of the object.Chemical Hazard Release: Uncontrolled release of a chemical from its containment that either threatens to, or does, cause exposure to a chemical hazard. Such an incident may occur accidentally or deliberately.Hazardous Substances: Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.Stupor: A state of reduced sensibility and response to stimuli which is distinguished from COMA in that the person can be aroused by vigorous and repeated stimulation. The person is still conscious and can make voluntary movements. It can be induced by CENTRAL NERVOUS SYSTEM AGENTS. The word derives from Latin stupere and is related to stunned, stupid, dazed or LETHARGY.National Institute for Occupational Safety and Health (U.S.): An institute of the CENTERS FOR DISEASE CONTROL AND PREVENTION which is responsible for assuring safe and healthful working conditions and for developing standards of safety and health. Research activities are carried out pertinent to these goals.Dizziness: An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.Occupational Exposure: The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.Local Lymph Node Assay: The local lymph node assay (LLNA) is an alternative method for the identification of chemicals that have the ability to cause skin sensitization and allergic contact dermatitis. Endpoints have been established so fewer animals are required and less painful procedures are used.National Academy of Sciences (U.S.): A United States organization of distinguished scientists and engineers established for the purpose of investigating and reporting upon any subject of art or science as requested by any department of government. The National Research Council organized by NAS serves as the principal operating agency to stimulate and support research.Animals, LaboratoryInstitute of Medicine (U.S.): Identifies, for study and analysis, important issues and problems that relate to health and medicine. The Institute initiates and conducts studies of national policy and planning for health care and health-related education and research; it also responds to requests from the federal government and other agencies for studies and advice.Neuropsychology: A branch of psychology which investigates the correlation between experience or behavior and the basic neurophysiological processes. The term neuropsychology stresses the dominant role of the nervous system. It is a more narrowly defined field than physiological psychology or psychophysiology.Academies and Institutes: Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.Laboratory Animal Science: The science and technology dealing with the procurement, breeding, care, health, and selection of animals used in biomedical research and testing.United StatesClutch Size: The number of offspring produced at one birth by an oviparous or ovoviviparous animal.Play and Playthings: Spontaneous or voluntary recreational activities pursued for enjoyment and accessories or equipment used in the activities; includes games, toys, etc.Slaves: A person involuntarily owned or controlled by another and exploited for forced or compulsory work or service.Nesting Behavior: Animal behavior associated with the nest; includes construction, effects of size and material; behavior of the adult during the nesting period and the effect of the nest on the behavior of the young.Oviposition: The process of laying or shedding fully developed eggs (OVA) from the female body. The term is usually used for certain INSECTS or FISHES with an organ called ovipositor where eggs are stored or deposited before expulsion from the body.Electrical Equipment and Supplies: Apparatus and instruments that generate and operate with ELECTRICITY, and their electrical components.Dental High-Speed Equipment: Tools used in dentistry that operate at high rotation speeds.Mercuric Chloride: Mercury chloride (HgCl2). A highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant.Fertility: The capacity to conceive or to induce conception. It may refer to either the male or female.Choroid Diseases: Disorders of the choroid including hereditary choroidal diseases, neoplasms, and other abnormalities of the vascular layer of the uvea.Medicine, East Asian Traditional: Medical practice or discipline that is based on the knowledge, cultures, and beliefs of the people in EAST ASIA.Infertility, Male: The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.Germ Cells: The reproductive cells in multicellular organisms at various stages during GAMETOGENESIS.Acrylonitrile: A highly poisonous compound used widely in the manufacture of plastics, adhesives and synthetic rubber.Hydrogen Cyanide: Hydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Skin Absorption: Uptake of substances through the SKIN.Irritants: Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.Skin Irritancy Tests: Tests or bioassays that measure the skin sensitization potential of various chemicals.Oxidoreductases Acting on CH-NH2 Group Donors: Enzymes catalyzing the dehydrogenation of or oxidation of compounds containing primary amines.Famous PersonsHistoryHistory, 18th Century: Time period from 1701 through 1800 of the common era.Allergy and Immunology: A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.Hypoplastic Left Heart Syndrome: A condition caused by underdevelopment of the whole left half of the heart. It is characterized by hypoplasia of the left cardiac chambers (HEART ATRIUM; HEART VENTRICLE), the AORTA, the AORTIC VALVE, and the MITRAL VALVE. Severe symptoms appear in early infancy when DUCTUS ARTERIOSUS closes.District of Columbia: A federal area located between Maryland and Virginia on the Potomac river; it is coextensive with Washington, D.C., which is the capital of the United States.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.

Glutamate transporter subtype 1 (GLT-1) activator ceftriaxone attenuates amphetamine-induced hyperactivity and behavioral sensitization in rats. (1/44)

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Altered central sensitization in subgroups of women with vulvodynia. (2/44)

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How to explain central sensitization to patients with 'unexplained' chronic musculoskeletal pain: practice guidelines. (3/44)

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Central sensitization of nociceptive neurons in rat medullary dorsal horn involves purinergic P2X7 receptors. (4/44)

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Importance of associative learning processes for one-trial behavioral sensitization of preweanling rats. (5/44)

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Peripheral injury induces long-term sensitization of defensive responses to visual and tactile stimuli in the squid Loligo pealeii, Lesueur 1821. (6/44)

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Spinal cord injury triggers an intrinsic growth-promoting state in nociceptors. (7/44)

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The development and psychometric validation of the central sensitization inventory. (8/44)

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Do you remember my massive post about CSS, Central Sensitivity Syndrome? The basic premise was that some peoples hyper-sensitivity may be related to an amplification of certain neurotransmitter pathways which then cause reactivity, pain and mood changes. I detailed what kind of pathways go wrong and the mainstream meds currently being used to dampen them.…
Does acetaminophen activate endogenous pain inhibition in chronic fatigue syndrome-fibromyalgia and rheumatoid arthritis: a double-blind randomized controlled cross-over trial. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Central sensitivity syndrome is a rising umbrella term for fibromyalgia, chronic fatigue syndrome and related conditions. See what that means.
INTRODUCTION The stimulus of surgical trauma provokes peripheral and central sensitivity, with modification of neurons and resulting in allodynia, hyperalgesia and increase of postoperative pain intensity1. It also causes increase in the concentrations of cytokines 2,3. Pro-inflammatory cytokines (TNF-α, IL-1, IL-6, IL-8) indirectly modulate pain through the release of substances like nitric oxide, oxygen free radicals, prostaglandins, and excitatory amino acids from microglia and astrocytes, inducing peripheral and central sensitivity and hyperalgesia 4. NMDA receptors have an important role in processing pain. The activation of these receptors by excitatory neurotransmitters, especially glutamate, is essential to the development of central sensitivity and amplification of pain response 1. Some drugs have been investigated to prevent or modify these alterations in the central nervous system. Ketamine is an antagonist of NMDA receptors and the S(+)-ketamine isomer is more powerful than the ...
This study describes the patient characteristics and healthcare utilization of a chronic pain population within an integrated healthcare system in northern California.
Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central sensitization. Central sensitization manifests as pain hypersensitivity, particularly dynamic tactile allodynia, secondary …
Fibromyalgia is currently understood to be a disorder of central pain processing or a syndrome of central sensitivity. Clauw describes the syndrome as a diffuse problem of sensory
Hi everyone, My doctor told me I have this, and thats why the pain is getting steadily stronger even though the IC probably isnt. I say probably isnt because pain is the only symptom at this point. There were some urinary symptoms in the beginning (1/07) and they disappeared after a few months. I know I should be grateful for that, and I really am. Im not sure I understand, though, what central sensitization means in terms of treatment. Does anyone know if central sensitization
Preclinical Findings Presented at the 2010 Joint Annual Meeting of the International Continence Society and the International Urogynecological Association Aug 2
Chapter 5 questions at Bradley University StudyBlue - Learn what central sensitization means, For example, you may not have a It may be due to any combination of the following:
This web site is run by an Arthritis Specialist based in Dubai, United Arab Emirates. On this site you will find news about the latest in arthritis, information about research results in the field, tips and information and diet and exercise, and much more.. More ...
The BfArM would like to draw attention to the recent SCENIHR publication regarding the use of surgical meshes in urogynecological surgery.
Background Opioid analgesics such as morphine and meperidine have been used to control moderate to severe pain for many years. However, these opioids have many side effects, including the development...
Semantic Scholar extracted view of Pain perception and endogenous pain modulation in angina pectoris. by Christine A. Droste et al.
Hi I have recently been diagnosed with Central Sensitisation and Chronic Migrainous State. This is after three years of a range of strange symptoms which I did
The American Urogynecologic Society and the International Urogynecological Association have honored the University of Alabama at Birminghams Dep...
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Understanding the perception of pain is important in the treatment of many conditions. When a tissue in the body is damaged, peripheral sensitization of nociceptors occurs as a protective mechanism by the body in order to prevent further use of a damaged structures (which if used, could further damage the tissue as well as surrounding…
TriAgain, my experience has been similar. Triathlon to joint pain. Except mine started with my hips and the other important difference I have to say Ive sadly had no progress. What I find works best for me is flow. By which I mean if I get into a state where I am completely and utterly absorbed by whatever Im doing and am happy then the pain seems to resolve to some extent. Im not sure if this is the bodys endogenous pain killers - endomorphine and endocannabinoid pathways or something else. It would kind of make sense as it seems to last for a while afterwards. Its not just a case of being diverted. It lasts longer than the diversion. I have been increasingly speculating that being stressed and focussed on the pain not just amplifies the pain which I think is pretty well established in the academic literature but causes actual joint damage. Ive actually found a serious academic paper which kind of makes this leap. The nervous system goes two ways. You sensory receptors send signals to the ...
Chemists at LMU Munich have collaborated with colleagues at Berkeley and Bordeaux to perform a series of lab experiments on pain inhibition and pain-sensitive neurons. They have discovered something like a pain switch, allowing the inhibition of the activity of pain-sensitive neurons. Findings were published in February of this year in Nature Methods. The researchers…
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Background Fibromyalgia Syndrome (FMS) is a persistent and debilitating disorder estimated to impair the quality of life of 2-4% of the population, with 9:1 female-to-male incidence ratio. FMS is an important representative example of central nervous system sensitization and is associated with abnormal brain activity. Key symptoms include chronic widespread pain, allodynia and diffuse tenderness, along with fatigue and sleep disturbance. The syndrome is still elusive and refractory. The goal of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) on symptoms and brain activity in FMS. Methods and Findings A prospective, active control, crossover clinical trial. Patients were randomly assigned to treated and crossover groups: The treated group patients were evaluated at baseline and after HBOT. Patients in the crossover-control group were evaluated three times: baseline, after a control period of no treatment, and after HBOT. Evaluations consisted of physical examination, including
BACKGROUND Fibromyalgia Syndrome (FMS) is a persistent and debilitating disorder estimated to impair the quality of life of 2-4% of the population, with 9:1 female-to-male incidence ratio. FMS is an important representative example of central nervous system sensitization and is associated with abnormal brain activity. Key symptoms include chronic widespread pain, allodynia and diffuse tenderness, along with fatigue and sleep disturbance. The syndrome is still elusive and refractory. The goal of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) on symptoms and brain activity in FMS. METHODS AND FINDINGS A prospective, active control, crossover clinical trial. Patients were randomly assigned to treated and crossover groups: The treated group patients were evaluated at baseline and after HBOT. Patients in the crossover-control group were evaluated three times: baseline, after a control period of no treatment, and after HBOT. Evaluations consisted of physical examination, including
There also appears to be a connection between IC and other syndromes such as chronic fatigue syndrome (CFS), fibromyalgia, irritable bowel syndrome and vulvodynia and dyspareunia (pain on intercourse).All may have a connection between what has been called Central Sensitivity Syndrome (CSS).. Patients with CSS become sensitised to things that are processed by the central nervous system: lights, odours, smell, touch and pressure on the body. This explains the connection between the above conditions and also the following: migraines, restless legs syndrome, multiple chemical sensitivity, temperomandibular joint dysfunction (TMJ) and dysmenorrhoea (painful periods). Some patients have more than one condition, and this helps make sense of the connection.. It appears irritable bowel syndrome, interstitial cystitis and reproductive and pelvic pain may have a connection through nerve pathways in the pelvis. Researchers have demonstrated a "cross-sensitisation" between nerves in the bladder, bowel and ...
Scotopic sensitivity syndrome, also known as Irlen Syndrome and Visual Stress Syndrome, approximating in some ways to Meares Irlen syndrome, and Visual Stress, refers to visual perceptual disorder(s) affecting primarily reading and writing based activities.
Scotopic sensitivity syndrome is a disorder that leads to a variety of symptoms that are related to vision. The signs of scotopic...
Abramowitch, S.D., 2013, "Mesh Complications: Hypothesizing About the Cause," American Urogynecological Societys Mesh special Interest Group, Las Vegas, NV.. Abramowitch, S.D., 2013, "Trying to Clean Up the Mess of Urogynecological Mesh," Biomedical Engineering Graduate Seminar Series, The University of Akron.. Abramowitch, S.D., 2013, "Urogynecological Mesh: The Data is Long Overdue," Engineering Science and Mechanics Seminar Series, Virginia Tech University.. Abramowitch, S.D., Maiti, S., Moalli, P., Pal, S., and Thunes, J.R., 2013, "Stiffness Mismatch between Prolapse Meshand Vaginal Tissue Impacts Stresses in the Vagina," 34th Annual Meeting of American Urogynecologic Society, Las Vegas, NV.. Barone, W.R., Amini, R., Maiti, S., Moalli, P.A., and Abramowitch, S.D., 2013, "Surface Curvature of CommonProlapse Meshes Alters under Variable Loading Conditions," 34th Annual Meeting of American Urogynecologic Society, Las Vegas, NV.. Barone, W.R., Moalli, P.A., and Abramowitch, S.D., 2013, ...
OBJECTIVE: The neural mechanisms of pain in knee osteoarthritis (OA) are not fully understood, and some patients have neuropathic-like pain associated with central sensitization. To address this, we undertook the present study in order to identify central sensitization using neuroimaging and PainDETECT and to relate it to postarthroplasty outcome. METHODS: Patients awaiting arthroplasty underwent quantitative sensory testing, psychological assessment, and functional magnetic resonance imaging (fMRI). Neuroimaging (fMRI) was conducted during punctate stimulation (n = 24) and cold stimulation (n = 20) to the affected knee. The postoperative outcome was measured using the Oxford Knee Score, patient-reported moderate-to-severe long-term pain postarthroplasty, and a range of pain-related questionnaires. RESULTS: Patients with neuropathic-like pain presurgery (identified using PainDETECT; n = 14) reported significantly higher pain in response to punctate stimuli and cold stimuli near the affected joint (P | 0
Ethnic differences in central sensitization of pain processing and stress-relevant endogenous pain regulatory mechanisms were examined. Forty-four African Americans (AAs; 50% women) and 44 non-Hispanic Whites (nHWs; 50% women) matched for socioeconomic status, were tested for pain responses to the temporal summation of heat pulses and ischemic and cold pain. Resting and stress blood pressure (BP) and norepinephrine (NE) were assessed. AAs had heightened pain responses to all 3 pain tasks relative to nHWs. In nHWs, higher BP and NE were related to reduced pain. In AAs, there was no relationship between BP and pain, but higher NE was related to increased pain. This study provides evidence for ethnic differences in centrally mediated pain and extends prior research demonstrating ethnic differences in endogenous pain regulatory mechanisms. These results have implications for understanding biobehavioral factors contributing to ethnic disparities in clinical pain ...
A 20 year old myopic Sudanese female presented at our hospital with a central visual field defect of her right eye, associated with photopsia. Visual acuity was 0.3; intraocular pressure was 16 mm Hg. Funduscopic examination of the affected eye showed some pigment epithelial alterations in the macular area, with an irregular macular reflex. Upon visual field examination, the affected eye showed a 12 dB decrease in central sensitivity, and a small blind spot enlargement was seen. No such changes were found in the left eye. OCT showed degeneration or disarray of foveal photoreceptor outer segments in the ...
These data identify the hypothalamic ObRb as a gene modulated after metformin treatment and suggest that the anorectic effects of the drug are potentially mediated via an increase in the central sensitivity to leptin ...
Bo K, Frawley HC, Haylen BT, Abramov Y, Almeida FG, Berghmans B, Bortolini M, Dumoulin C, Gomes M, McClurg D, Meijlink J, Shelly E, Trabuco E, Walker C, Wells A. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for the conservative and nonpharmacological management of female pelvic floor dysfunction. Int Urogynecol J 2017 Feb; 28 (2):191-213 Epub 2016 Dec 05 ...
Some surgeons work with other medical professionals in order to treat complex cases: such as a colorectal surgeon, urogynecological surgeon, or thoracic surgeon. This does not mean that the specialist has a lower skill set by any means. While a group of surgeons are now using robotic surgery, some have opted to continue using traditional surgical techniques. This does not mean that one is better or more qualified than the other. Surgery is not based on the tools used, but the hands controlling the tools and the knowledge behind those hands. ...
By Andy Choi OrthoSensor, the developer of sensor-assisted surgery systems and intelligent orthopedic implants based in Sunrise, Florida, has announced that its
C) no, not necessarily... it depends how much damage there is... but pain sensation is both a physiological and psychological responce... many people have very traumatic sports injuries and they dont feel the pain to much after the event... as adrenaline may well delay a pain responce... but we also have other endogenous pain killers in bodies (endogenous opioids, neurotransmitters...etc ...
MT Pinto joined Ipatimup as an Investigator Ciência 2008 (2009) of the Cancer Genetics Group and was mainly dedicated to the study of cancer related features using the CAM model. After setting up the lab and implementing several CAM assays, she established the "In vivo CAM assays service" at Ipatimup (2012) and founded the spin-off "Expertus, CAM assays" (2013-2015). MT Pinto graduated in Biochemistry (FCUP; 1999) and both MSc (FMUL; 2001) and PhD (FMUP; 2008) theses concerned the study of the endogenous pain control system in acute and chronic pain states and involved extensive use of animal models. MT Pinto has published 26 papers in international peer reviewed journals (Q1) with an H index of 12 (ResearcherID: J-2519-2013). She is co-author of two patents. ...
PMID: 22558610 Aims: To investigate the influence of noxious stimulation of the temporomandibular joint (TMJ) on conditioned pain modulation (CPM) and the possible influence of gender on such CPM effects in the craniofacial region of humans. Methods: Twenty healthy men and 20 healthy women participated in two sessions. Conditioning stimulation (CS) was standardized mechanical stimulation of pericranial muscles at a pain level of 5 on a 0 to 10 visual analog scale (VAS). Intra-articular electrical stimuli were applied to the left TMJ with an intensity around VAS = 5 (painful session). No electrical stimulation was applied in the control session. Pressure pain threshold (PPT) and pressure pain tolerance threshold (PPTol) were used as responses to pressure (test) stimuli and were assessed in the right masseter muscle and left forearm before and during TMJ stimulation in addition to the CS (during, immediately after, and 10 minutes after CS). PPT and PPTol were analyzed by multilevel analysis of ...
PHOENIX, March 7, 2014 /PRNewswire-USNewswire/ -- Stanford Researchers Show Conditioned Pain Modulation Equals Less Activity in the Human Spinal Cord.
The International Urogynecological Association (IUGA) is a non-profit international organization dedicated to the advancement of urogynecological knowledge around the world through education and the promotion of basic and clinical research on disorders of the female pelvic floor.. IUGA was founded in 1975 and has organized scientific meetings every year in nearly every corner of the world to promote the exchange of urogynecological information to thousands of physicians and healthcare providers.. Visit www.iuga.org for more information.. Privacy Policy ...
Chronic pain is associated with dysfunctional endogenous pain modulation, involving both central opioid and serotonergic (5-HT) signaling. Fibromyalgia (FM) is a chronic pain syndrome, characterized by widespread musculoskeletal pain and reduced exercise-induced hypoalgesia (EIH). In this study, we...
BACKGROUND: Current multimodal approaches for the management of non-specific patellofemoral pain are not optimal, however, targeted intervention for subgroups could improve patient outcomes. This study explores whether subgrouping of non-specific patellofemoral pain patients, using a series of low cost simple clinical tests, is possible. METHOD: The exclusivity and clinical importance of potential subgroups was assessed by applying à priori test thresholds (1 SD) from seven clinical tests in a sample of adult patients with non-specific patellofemoral pain. Hierarchical clustering and latent profile analysis, were used to gain additional insights into subgroups using data from the same clinical tests. RESULTS: 130 participants were recruited, 127 had complete data: 84 (66%) female, mean age 26 years (SD 5.7) and mean body mass index 25.4 (SD 5.83), median (IQR) time between onset of pain and assessment was 24 (7-60) months. Potential subgroups defined by the à priori test thresholds were not mutually
Linear regression model-adjusted week 12 mean score by treatment group.. Purpose: To assess the severity of pain Population: Patients with pain from chronic diseases or conditions such as cancer, osteoarthritis and low back pain, or with pain from acute conditions such as postoperative pain Responsiveness: Responds to both behavioral and pharmacological pain interventions Method: Self-report or interview Scoring: Higher scores indicate more pain Range: 0-10 ...
Pain studies using electrophysiological recording (EEG, Evoked Potentials (EP) and MEG) demonstrate shifts in the frequency spectrum in the presence of chronic or induced pain, to the theta and beta frequency bands. Source localization of scalp-recorded EEG data Low-Resolution Electromagnetic Tomographic Analysis (LORETA) in patients with intractable unilateral or bilateral neuropathic pain, when compared to pain-free controls identified similar neural activity sources as reported in the literature with conventional neuroimaging methods.. Preliminary data collected at the Brain Research Laboratories, Department of Psychiatry at NYUSOM (under a research contract from PainQx) has been published demonstrating feasibility/proof of concept for an approach which uses QEEG to identify and quantify significant over and under activation of cortical and subcortical regions of interest (ROI) of the brain in a chronic pain population. Using QEEG source localization methods, this published pilot study ...
In summary, GSE elevated expression of proteins in trigeminal ganglia and TNC known to decrease neuronal excitability and suppressed CFA-induced expression of several proteins implicated in peripheral and central sensitization ...
Author: Steven Stanos. Osteoarthritic conditions and resultant pain are common in most clinicians practice. Dr. Stanos discusses the role of central sensitization in pain causation, and the benefits and risks associated with various pharmacological treatment options.. ...
Neuropathic or idiopathic pain patients will be assessed with the variety of pain tests including the conditioned pain modulation (CPM) and temporal summation (TS). Then, they will be offered on the double-blind design a several weeks treatment with either pregabalin or duloxetine. Patients will be followed-up weekly by phone for their pain relief and will be re-assessed in the lab toward the end of the treatment. The investigators suggest that patients with less-efficient CPM (deficient pain inhibition) will earn more pain relief from the treatment with duloxetine, while the patients with the enhanced pain summation will response better to pregabalin ...
101 women with proven stressed urinary incontinence were included in the study. After the TVT procedure 90 women were evaluated. As a part of the complex urogynecological investigation before surgery the transperineal ultrasound scan was performed in supine position, urinary bladder was filled to 300 ml. In the orthogonal system of coordinates the position and mobility of the whole urethra before surgery were assessed. Control examination was done 3-6 months after the surgery. The changes induced by the surgery were assessed. For the statistical evaluation t-test, Wilcox test, F test, Kruskal-Wallis test and ANOVA were used ...
Ibudilast (development codes: AV-411 or MN-166) is an anti-inflammatory drug used mainly in Japan, which acts as a phosphodiesterase inhibitor, inhibiting the PDE4 subtype to the greatest extent, but also showing significant inhibition of other PDE subtypes. Ibudilast has bronchodilator, vasodilator and neuroprotective effects, and is mainly used in the treatment of asthma and stroke. It inhibits platelet aggregation, and may also be useful in the treatment of multiple sclerosis. Ibudilast crosses the blood-brain barrier and suppresses glial cell activation. This activity has been shown to make ibudilast useful in the treatment of neuropathic pain and it not only enhances analgesia produced by opioid drugs, but also reduces the development of tolerance. It may have some use reducing methamphetamine and alcohol addiction. Ibudilast is listed as being an antagonist at the toll-like receptor 4 (TLR4). This likely plays a large part in its effect, specifically its synergy with opioid drugs, its ...
We have shown that just as the physiological reaction of saliva secretion was provoked in Pavlovs dogs by the ringing of a bell, an analogous effect occurs regarding the ability to mask pain in humans, said Fernand Anton, Professor of Biological Psychology at the University of Luxembourg. Conversely, similar learning effects may be involved in the enhancement and maintenance of pain in some patients, added Raymonde Scheuren, lead researcher in this study. Weitere Informationen:http://orbilu.uni.lu/handle/10993/16824 - link to the full scientific article Beep Tones Attenuate Pain following Pavlovian Conditioning of an Endogenous Pain Control Mechanismhttp://www.uni.lu - homepage of the University of Luxembourg ...
Contrary to what Dr Dembski has stated, this simple example shows that a regular process, such as ROT13, can create CSI. Since a regular process can create CSI it is therefore incorrect to assert that a regular process cannot be the origin of any CSI found in living organisms. This is a major problem for IDs attempts to use the presence of CSI as a marker of design. CSI can be generated by non-design processes such as ROT13 ...
Patellofemoral Pain (PFP) is highly prevalent among adults and adolescents. Localized mechanical hyperalgesia around the knee and tibialis anterior have been observed in people with PFP, but limited knowledge of potential manifestations of central sensitisation exists. The aims of this study were to study conditioned pain modulation (CPM) and wide-spread hyperalgesia in adults with PFP. This assessor-blinded cross-sectional study design compared CPM and mechanical pressure pain thresholds (PPT) between 33 adults (23 females) diagnosed with PFP and 32 age and sex matched pain-free controls. The investigator taking the PPT measurements was blinded to which participants had PFP. PPTs were reliably measured using a Somedic hand-held pressure algometer at three sites: 1) The centre of the patella, 2) the tibialis anterior muscle and 3) a remote site on the lateral epicondyle. For the assessment of CPM, experimental pain was induced to the contralateral hand by immersion into a cold water bath ...
0048] Furthermore, referring to FIGS. 10, 11, and 16, a filter crop 60 can also be used in conjunction with the eyewear 10 and screen filter 52 when reading from a computer screen 50 or the like. The filter crop 60 may be hand-held and comprises a frame 62 made of a thin layer of closed cell foam or other light-weight material (such as paper) that has been laminated between two layers of clear plastic film. In the middle of the frame 62, two blocking pieces 64 are arranged, forming a slot 66 in between the two blocking pieces. The blocking pieces 64 are made of a neutral grey plastic film. Preferably, the blocking pieces 64 are glued or taped in place on the frame 62. The edges of the blocking pieces 64 adjacent to the slot 66 may be tensioned with pieces of elastic thread to keep the edges taunt and straight. The threads are attached to the frame 62 and looped through a hole in the blocking piece 64 and a knot is tied. The thread is pulled to create a tension in the thread, and the knot is ...
18.EdwardsRR,FillingimRB: Effectsofageontemporalsummationand habituationofthermalpain:clinicalrelevanceinhealthyolderand youngeradults. JPain 2001, 2 (6):307 317. 19.FillingimRB,MaixnerW,KincaidS,SilvaS: Sexdifferencesintemporal summationbutnotsensory-discriminativeprocessingofthermalpain. Pain 1998, 75 (1):121 127. 20.ValenciaC,KindlerLL,FillingimRB,GeorgeSZ: Investigationofcentralpain processinginshoulderpain:convergingresultsfrom2musculoskeletal painmodels. jpainoffjAmPainSoc 2012, 13 (1):81 89. 21.PriceDD,McHaffieJG: Effectsofheterotopicconditioningstimulionfirst andsecondpain:apsychophysicalevaluationinhumans. Pain 1988, 34 (3):245 252. 22.HerreroJF,LairdJM,Lopez-GarciaJA: Wind-upofspinalcordneurones andpainsensation:muchadoaboutsomething? ProgNeurobiol 2000, 61 (2):169 203. 23.LautenbacherS,KunzM,BurkhardtS: TheeffectsofDNIC-typeinhibition ontemporalsummationcomparedtosinglepulseprocessing:doessex matter? Pain 2008, 140 (3):429 435. 24.FarrellM,GibsonS: ...
There are over 50 types of arthritis, each demanding an appropriate approach to therapy, not just pain inhibition. Conservative treatment should be tried first
Guide to Canadian health care training schools. Find a medical program plus answers to some of the most common FAQs about the field.
Researchers found that educating fibromyalgia patients in pain physiology improved their bodies natural ability to inhibit pain.
July 2013 References for Research Update Devin J. Starlanyl for http://www.sover.net/~devstar. Ablin JN, Buskila D. 2013. Fibromyalgia syndrome - novel therapeutic targets. Maturitas [June 3 Epub ahead of print]. "Fibromyalgia is a syndrome characterized by the presence of chronic widespread pain, representing sensitization of the central nervous system. The pathophysiology of fibromyalgia is complex and remains in evolution, encompassing diverse issues such as disturbed patterns of sleep, altered processing and decreased conditioned pain modulation at the spinal level, as well as increased connectivity between various pain-processing areas of the brain. This evolution is continuously uncovering potential novel therapeutic targets. Treatment of fibromyalgia is a multi-faceted endeavor, inevitably combining pharmacological as well as non-pharmacological approaches. Certain specific ligands and selective nor-epinephrine-serotonin reuptake inhibitors are the current mainstays of pharmacological ...
Assuring patients with chronic pain they are not crazy by explaining the neurophysiology behind what is happening in their brain and body can be life changing. Increasing our patients knowledge about physical conditions can reduce anxiety and provid
Just want to sanity check...with my numbers my CSI is currently at -.08, even with a pH of 8.2....before I go running to drop it back to 7.8 (Ill prob do it later today or tomorrow morning), is it ok to run that high as long as the CSI is happily balanced?
SITE DISCLAIMER: Do these products "cure" anything? Of course not… but it stands to reason that if you cleanse your body and feed it the finest nutrition available, giving it everything it needs in balance, on a daily basis, that your body will do what nature intended, and give you the best possible chance to fend off sickness and disease. This Temporomandibular joint disorder information is not presented by a medical practitioner and is for educational and informational purposes only. The Temporomandibular joint disorder content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any Temporomandibular joint disorder questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read ...
Learn more about In Her Own Words: Living With Temporomandibular Joint Disorder at Portsmouth Regional Hospital Sharri is a 30-year-old single woman living in Southern...
Learn more about In Her Own Words: Living With Temporomandibular Joint Disorder at Memorial Hospital Sharri is a 30-year-old single woman living in Southern California...
Reviews and ratings for advil when used in the treatment of temporomandibular joint disorder. Share your experience with this medication by writing a review.
TY - JOUR. T1 - Mexiletine usage in a chronic pain clinic. T2 - Indications, tolerability, and side effects. AU - Romman, Adam. AU - Salama-Hanna, Joseph. AU - Dwivedi, Samvid. PY - 2018/9/1. Y1 - 2018/9/1. N2 - Background: Background: Intravenous lidocaine has multiple applications in the management of acute and chronic pain. Mexiletine, an oral lidocaine analogue, has been used in a number of chronic pain conditions although its use is not well characterized. Objectives: To report our experience using mexiletine in a chronic pain population, specifically looking at tolerability, side effects, and EKG changes. Study Design: Retrospective, cohort study. Setting: Multiple pain clinic locations in an integrated multispecialty health system. Methods: All patients who had a mexiletine prescription between August 2015 and August 2016 were queried via the electronic medical record. Each chart was examined for demographics, QTc changes on EKG, length of use, and reasons for stoppage. Results:There were ...
Several lines of evidence indicate that the use of stimulant drugs, including methylphenidate (MPD), increases tobacco smoking. This has raised concerns that MPD use during adolescence could facilitate nicotine abuse. Preclinical studies have shown that repeated treatment with an addictive drug produces sensitization to that drug and usually cross-sensitization to other drugs. Behavioral sensitization has been implicated in the development of drug addiction. We examined whether repeated oral MPD administration during adolescence could induce behavioral sensitization to MPD and long-lasting cross-sensitization to nicotine. Adolescent male Wistar rats were treated orally with 10 mg/kg MPD or saline (SAL) from postnatal day (PND) 27 to 33. To evaluate behavioral sensitization to MPD in adolescent rats (PND 39), the SAL pretreated group was subdivided into two groups that received intragastric SAL (1.0 mL/kg) or MPD (10 mg/kg); MPD pretreated rats received MPD (10 mg/kg). Cross-sensitization was ...
TY - JOUR. T1 - Assessment of CPM reliability. T2 - quantification of the within-subject reliability of 10 different protocols. AU - Vaegter, Henrik Bjarke. AU - Petersen, Kristian Kjær. AU - Mørch, Carsten Dahl. AU - Imai, Yosuke. AU - Arendt-Nielsen, Lars. PY - 2018/10/25. Y1 - 2018/10/25. KW - conditioned pain modulation. KW - cuff algometry. KW - pain sensitivity. KW - pain threshold. KW - pain tolerance. KW - reliability. KW - test-retest. UR - http://www.scopus.com/inward/record.url?scp=85050669959&partnerID=8YFLogxK. U2 - 10.1515/sjpain-2018-0087. DO - 10.1515/sjpain-2018-0087. M3 - Journal article. VL - 18. SP - 729. EP - 737. JO - Scandinavian Journal of Pain. JF - Scandinavian Journal of Pain. SN - 1877-8860. IS - 4. ER - ...
Rocabado 6x6 exercises refer to a system of movements that help treat temporomandibular joint disorders. Mariano Rocabado, DPT, devised the program to help...
Learn about Temporomandibular Joint Disorders (TMD) symptoms and causes from experts at Boston Childrens, ranked best Childrens Hospital by US News.
Learn more about Temporomandibular Joint Disorders (TMD) symptoms, diagnosis, and treatments from experts at Boston Childrens, ranked best Childrens Hospital by US News.
Temporomandibular joint disorder (TMD) Denver CO - Dr. Nancy Gill and Dr. Dallas Kenson offer TMD treatment in Golden, Denver, Colorado and nearby areas.
MUS represent the gold standard treatment for SUI, with high rates of recovery of continence. Since transvaginal tape was introduced in 1996, this procedure has become one of the most commonly used SUI treatments [21]. The TOT procedure appears to be associated with a lower incidence of postoperative voiding dysfunction [27]. However, some patients may present voiding dysfunction after surgery. In fact, no standard definition exists of postoperative voiding dysfunction after anti-incontinence surgery.. The International Urogynecological Association/International Continence Society joint report on the terminology for female pelvic floor dysfunction defines voiding dysfunction as follows: "Voiding dysfunction, a diagnosis by symptoms and urodynamic investigations, is defined as abnormally slow and/or incomplete micturition. Hesitancy is a complaint of a delay in initiating micturition. Slow stream is a complaint of urinary stream perceived as slower compared to previous performance or in ...
TMJ symptoms, diagnosis and treatment. symptoms include headaches, facial pain, neck pain, tinnitus, dizziness, TMJ pain and clicking or popping joints.
The diagnosis of temporomandibular disorders (TMD) is based on history, signs and symptoms. Pain can arise from the area of the mandible due to several distinct
Temporomandibular disorder (TMD) is a diagnosis that serves as an umbrella for a variety of underlying conditions. These conditions manifest themselves as pain or
Temporomandibular diseases and disorders, commonly referred to as TMJ, represent a family of complex and poorly understood health problems manifested by pain in and around the jaw and associated ...
The various subtypes of temporomandibular disorders and different imaging exams available for diagnosis and indication influence the choice of the most appropriate examin..
Risk Factors Studies have been performed to determine TMD risk factors based on gender and age, but complexities in understanding the causes of TMD make
means that you are leaving the NIH website.. This external link provides additional information that is consistent with the intended purpose of this site.. NIH cannot attest to the accuracy of a non-federal site.. Linking to a non-federal site does not constitute an endorsement by NIH or any of its employees of the sponsors or the information and products presented on the site.. You will be subject to the destination sites privacy policy when you follow the link.. ...
Ibudilast is an anti-inflammatory drug used to treat asthma, which is being investigated as a treatment for progressive multiple sclerosis. Find out more about ibudilast in this A-Z entry.
What is TMD? TMD stands for temporomandibular joint disorder, or TMJ disorder. Get relief from headaches with TMJ treatment. Call us in Anchorage today!
Tinnitus Cause: TMJ Disorder. Tinnitus, or ringing in the ears, is one symptom associated with temporomandibular joint disorder (TMJ/TMD).
Because of the many symptoms associated with TMJ or Temporomandibular Joint Disorder, several specialists may be required in its diagnosis and treatment. These specialists include dentists, primary...
Arm, Central Sensitization, Elbow, Electronic, Hyperalgesia, Hypersensitivity, Inflammation, Leg, Measures, Outcome Measures, Pain, Pain Management, Pain Threshold, Pain Thresholds, Patients, Pressure, Sensitivity, Tourniquet, Women
Cocaine is a naturally occurring alkaloid found within the leaves of a shrub, Erythroxylon coca. The earliest reported use of cocaine dates back to times when the ancient inhabitants of Peru used the leaves for religious ceremonies.
The spinal trigeminal nucleus is a nucleus in the medulla that receives information about deep/crude touch, pain, and temperature from the ipsilateral face. In addition to the trigeminal nerve (CN V), the facial (CN VII), glossopharyngeal (CN IX), and vagus nerves (CN X) also convey pain information from their areas to the spinal trigeminal nucleus.[1] Thus the spinal trigeminal nucleus receives input from cranial nerves V, VII, IX, and X. The spinal nucleus is composed of three subnuclei: subnucleus oralis (pars oralis), subnucleus caudalis (pars caudalis), and subnucleus interpolaris (pars interpolaris). The subnucleus oralis is associated with the transmission of discriminative (fine) tactile sense from the orofacial region, and is continuous with the principal sensory nucleus of V. The subnucleus interpolaris is also associated with the transmission of tactile sense, as well as dental pain, whereas the subnucleus caudalis is associated with the transmission of nociception and thermal ...
Pain in the jaw and noticeable limitations in jaw movements can be a sign of any of the Temporomandibular Joint Disorders (TMJ or TMD). As with other joints in the body, TMJ is also affected by injury and conditions such as arthritis. One or both joints may be affected in people with TMD, which can affect a persons ability to speak, eat, chew, swallow, make facial expressions, and even breathe.. Clenching or grinding your teeth, tightening your jaw muscles and stressing your TM joint can lead to TMJ disorders. It can also be a result of having a damaged jaw joint due to an injury or disease. Whatever the cause, the results may include a misaligned bite, pain, clicking, or grating noises when you open your mouth, or experience difficulty in opening your mouth wide.. More than 90% of TMD is muscle problems which can cause headaches and other types of pain in the jaw area. The reason for this muscle problem comes from the biting action or problems with the movement of the lower jaw.. We use a ...
The aim of the present study was to evaluate the production of superoxide anion (O(2)(-)) in the trigeminal complex nuclei after a functional mechanical overload of the teeth due to the preference for masticating on one side in rats. The preference for masticating on one side was induced by the discomfort due to a small abrasion of one molar; such lateralisation in mastication was confirmed by electromyography. The production of O(2)(-) was evaluated in the trigeminal nuclei by fluorescence microscopy after an injection of dihydroethidium. The results showed that there was an increased production of O(2)(-) in the subnucleus oralis of the spinal trigeminal nucleus in the same side where the mastication was preferred. This result demonstrates that an increased activity of non-painful sensory neurons can enhance the production of reactive oxygen species within the central second order sensory nuclei. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.. ...
ARA) - Parents do a lot of things for the sake of their children -- from sitting through soccer games in the freezing rain to making sure they eat a healthy, balanced diet to providing a safe, clean place to live. Unfortunately, many of the cleaning products commonly found on grocery store shelves and in your home are not as safe as you might think.. Take a minute to inventory the cleaning products you currently use. How many times do words like "danger," "warning," and "caution" appear on the labels? Cleaning products are exempt from the full ingredient disclosure on product labels as required for food and personal care products and enter the marketplace with little or no testing for potential health risks. But compelling evidence links the chemicals in household products to a whole range of conditions, including cancer, asthma, allergies, multiple chemical sensitivity syndrome, hormonal disruption and reproductive and developmental disorders. For example, many all-purpose cleaners, window ...
Temporomandibular joint disorder-also called TMJ or TMD-describes a group of conditions that affect the muscles in your jaw. The temporomandibular
Transcript Your TMJ is your temporal mandibular joint. Thats a big scientific word, what does it mean? Your temporal mandibular joint is your jaw joint. If
Asking questions is the best way to learn, of course, and chiropractic patients often ask questions about some of the health issues they face. Some
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Elimination of spinal neurons that possess the SPR using SP-SAP offers the unique opportunity to determine the role of SPR-expressing neurons, as well as other neurons, in pain processing. SP-SAP induced specific degeneration of neurons expressing SPR receptors. This observation was made previously (Mantyh et al., 1997; Nichols et al., 1999) and is supported by present data. An interesting finding of the present study was the proportional change in the functional classification of spinal neurons encountered in animals pretreated with SP-SAP. The proportion of HT neurons encountered in control animals was ∼36%, whereas only 7% of the neurons identified in SP-SAP-treated animals were HT. This suggests that SP-SAP targeted primarily HT neurons. It has been shown in cats that HT neurons possess more SPRs than WDR neurons (Ma et al., 1996, 1997), suggesting that HT neurons are more vulnerable to SP-SAP because of the greater number of SPRs on these neurons.. The absence of sensitization and windup ...
LA JOLLA, Calif., Dec. 07, 2017 (GLOBE NEWSWIRE) -- MediciNova, Inc., a biopharmaceutical company traded on the NASDAQ Global Market (NASDAQ:MNOV) and the JASDAQ Market of the Tokyo Stock Exchange (Code Number: 4875), today announced positive top-line results from MediciNovas clinical trial of MN-166 (ibudilast) in amyotrophic lateral sclerosis (ALS). Data analysis was conducted on the 51 subjects without non-invasive ventilation in the ITT (Intent To Treat) population. The trial achieved the primary endpoint of safety and tolerability, and also demonstrated efficacy trends in favor of MN-166 (ibudilast). MN-166 (ibudilast) demonstrated a favorable safety and tolerability profile. All subjects in the study received 100 mg of riluzole per day. There were 7 serious adverse events (SAEs) reported during the study but none of the SAEs were related to the study drug. All treatment-related adverse events (TRAEs) were mild to moderate in intensity and no severe or life-threatening TRAEs were reported. ...
Hi, my name is Dianne i have been suffering from Vulvodynia for 13 years now i burn when i dont have sex and burn during sex. I have seen Doctors and specialist and they dont know how to treat it.
Ethanol (EtOH)-induced behavioral sensitization (EIBS) is defined as an enhancement of locomotor activity following repeated EtOH exposure and is proposed to reflect an i..
Teehee thanks Ves! I know everyone is different, so I didnt want to be too harsh or frighten Mark!! The best thing to do is wait until the time is right and as
2011년도 1번 맥동 초음파가 흰쥐 전층 피부 절제 창상에 미치는 영향 , 2번 아래팔 전면부에 TENS 자극후 노뼈 동맥에서의 혈류 속도와 피부온도 변화 2012년 1번 경피신경전기자극이 전류지각 역치에 미치는 영향 2번 경피신경전기자극,역동전류, 단파치료 기기의 강도와 거리에 따른 전기장과 자기장의 세기 비교 3번 단파와 맥동단파 적용에 의한 노뼈동맥 혈류속도와 피부온도의 ...
Abuse of central nervous system (CNS) stimulants is common. Addiction to some CNS stimulants can quickly lead to medical, ... Drug tolerance, dependence, and sensitization as well as a withdrawal syndrome can occur. Stimulants enhance the activity of ... Amphetamine is a potent central nervous system (CNS) stimulant of the phenethylamine class that is approved for the treatment ... subscription required) Nehlig, A.; Daval, J. L.; Debry, G. (1 August 2016). "Caffeine and the central nervous system: ...
Repeated exposure causes skin sensitization and may cause central nervous system and liver damage. There are two main excretion ... Integrated Risk Information System, U.S. Environmental Protection Agency CDC - NIOSH Pocket Guide to Chemical Hazards - ...
... central nervous system effects include neuronal sensitization to tactile stimuli and mediation of some of the effects of ... mediate many of the central and peripheral physiologic functions of serotonin. Cardiovascular effects include contraction of ... "Functional activity of serotoninergic and melatoninergic systems expressed in the skin". Journal of Cellular Physiology. 196 (1 ...
There is a strong body of evidence that the so-called sensitization of the central nervous system contributes to the emergence ... The mechanism responsible for sensitization of the central nervous system at the level of the spinal cord is different from the ... thus preventing the sensitization of the central nervous system. Another effect of naproxen is the reduction of the ... Allodynia (Ancient Greek άλλος állos "other" and οδύνη odúnē "pain") refers to central pain sensitization (increased response ...
The pain appears to result from processes in the central nervous system and the condition is referred to as a "central ... Yunus MB (June 2007). "Role of central sensitization in symptoms beyond muscle pain, and the evaluation of a patient with ... classed as a disorder of pain processing due to abnormalities in how pain signals are processed in the central nervous system. ... pathology due to dysfunction of muscles and connective tissue as well as functional abnormalities in the central nervous system ...
Groves and Thompson dual-process theory of habituation posits that two separate processes exist in the central nervous system ... Much less is understood about sensitization than habituation, but the sensitization process is often observed along with the ... The Sokolov model assumes that when a stimulus is experienced several times the nervous system creates a model of the expected ... Thus when the habituation process exceeds the sensitization process behavior shows habituation, but if the sensitization ...
... noxious stimuli and inflammation cause an elevation of nociceptive input from the periphery to the central nervous system. ... inducing central sensitization. For instance, individuals experiencing complex regional pain syndrome demonstrate a diminished ... This phenomenon is related to neuroplasticity due to a maladaptive reorganization of the nervous system, both peripherally and ... Kaas' research project is focused on how these systems (somatosensory, cognitive, motor systems) respond with plastic changes ...
... is a neurological condition caused by damage or malfunction in the Central Nervous System (CNS) which ... causes a sensitization of the pain system. The extent of pain and the areas affected are related to the cause of the injury. ... is suspected in individuals who complain of pain or other abnormal sensations following injury to the central nervous system. ... Ratini, Melinda (2 March 2013). "Pain Management: Central Pain Syndrome". WebMD. NIH. Retrieved 6 February 2014. "Central Pain ...
... and central nervous system (CNS) sensitization are key neurologic processes that appear to be involved in the induction and ... swelling in the central nervous system), nociceptive sensitisation (which causes extreme sensitivity or allodynia), vasomotor ... Central Nervous System. Idiopathic pain syndromes. Local. Complex regional pain syndrome/Reflex sympathetic dystrophy. ... It is proposed that inflammation and alteration of pain perception in the central nervous system play important roles. It has ...
... central nervous system effects include neuronal sensitization to tactile stimuli and mediation of some of the effects of ... The 5-HT2 receptors (of which the 5-HT2B receptor is a subtype) mediate many of the central and peripheral physiologic ... "Functional activity of serotoninergic and melatoninergic systems expressed in the skin". Journal of Cellular Physiology. 196 (1 ...
... activation and sensitization of the trigeminal nerve, the autonomic nervous system, and central feedbacks. There are many ...
... in which she sought to define the constraints imposed on infant visual performance by the developing central nervous system. ... An interest in linking propositions can be seen in Teller's early work on spatial sensitization, which was thought to represent ... "spatial sensitization," the detectability of a test light is first decreased and then increased by adding light to successively ...
... which can lead to sensitization and hyper-excitability of the central nervous system, excito-neurotoxicity, and increasingly ... reduces excessive glutamate activity in the central nervous system and thereby may reduce excitotoxicity and withdrawal related ... an imbalance between inhibitory and excitatory amino acids and changes in monoamine release in the central nervous system, ... Changes in the glutamate system and GABA system may play an important role at different time points during benzodiazepine ...
Animal experiments have shown that, at very high concentrations, the ester has central nervous system depressant and lethal ... In rare cases exposure may cause sensitization of the mucous membrane and eruptions of the skin. The irritant effect of ethyl ... symptoms of central nervous system depression, secondary anemia and liver damage. In humans, concentrations of 400 ppm cause ...
There is a strong body of evidence that the so-called sensitization of the central nervous system contributes to the emergence ... The mechanism responsible for sensitization of the central nervous system at the level of the spinal cord is different from the ... thus preventing the sensitization of the central nervous system. Another effect of naproxen is the reduction of the ... Allodynia refers to central pain sensitization (increased response of neurons) following normally non-painful, often repetitive ...
In the mid-1950s it was proposed that serotonin had a role as a neurotransmitter in the central nervous system (CNS) of animals ... Also they are thought to promote neurogenic inflammatory response important for sensitization of sensory afferents, and also ... Most mammalian species, including man, have 5-HT1D binding sites widely distributed throughout the central nervous system. 5- ... but have a higher potential for central nervous side effects. Donitriptan and avitriptan were never marketed. The history of ...
Central nervous system[edit]. Rare reports have been made of malaise, dizziness, somnolence, insomnia, and vertigo. In severely ... where sensitisation occurs. Patients who take these agents develop higher levels of immunoglobulin E against food, whether they ... Pelot, Daniel, (M.D.). "Digestive System : New Drug for Heartburn". The New Book of Knowledge : Medicine & Health, Grolier : ... "The American Society of Health-System Pharmacists. Archived from the original on 2017-09-09. Retrieved Dec 1, 2015.. .mw-parser ...
... may result from disorders of the peripheral nervous system or the central nervous system (brain and spinal ... This phenomenon is called central sensitization. Central sensitization is an important mechanism of persistent neuropathic pain ... Neuropathic pain is pain caused by damage or disease affecting the somatosensory nervous system. Neuropathic pain may be ... may play a role in central sensitization. Peripheral nerve injury induces glia to release proinflammatory cytokines and ...
They could include diseases or disorders in the central nervous system or peripheral nervous system. Examples of neuropathic ... Noxious input to the spinal cord is known to produce central sensitization, which consists of allodynia, exaggeration of pain, ... or in the central nervous system (neuropathic, neurogenic, or psychogenic). Itch originating in the skin is known as ... Neuropathic itch can originate at any point along the afferent pathway as a result of damage of the nervous system. ...
... concentrating on the effects of drugs and drug addiction on the central nervous system neurotransmitters. She has written ... permanent dead link] "Brain opioidergic systems and neurobehavioral sensitization in addiction to alcohol". University of ... "brain opioidergic systems and neurobehavioral sensitization in addiction to alcohol". WorldCat listings of publications Sleeman ...
... is also expressed at high levels in the central nervous system and has been proposed as a target for treatment not only ... Phosphorylation of TRPV1 by protein kinase C have been shown to play a role in sensitization of TRPV1. The cleavage of PIP2 by ... Hence, there may be therapeutic potential in modulating TRPV1 in the central nervous system, perhaps as a treatment for ... Starowicz K, Cristino L, Di Marzo V (2008). "TRPV1 receptors in the central nervous system: potential for previously unforeseen ...
... is more effective and has virtually no central nervous system side effects in comparison to current drugs for pain ... Sensitization increases neuronal excitation following receptor channel activation. EMA401 antagonized human AT2R with a Ki of ... Neuropathic pain, in contrast, is long-lasting pain that develops when the peripheral and the central nervous system are ... EMA401 does not cross the blood-brain barrier, therefore has little effect on the central nervous system. Blood circulation ...
... nervous system are located outside the brain complex. The optic lobes contain 120 to 180 million neurons and the nervous system ... of the arms contains two-thirds of the total 500 million neurons in the nervous system. The octopus central brain contains 40 ... Second, the heightened sensitisation may also become chronic, persisting well beyond the tissues healing. This can mean that ... The nervous system of cephalopods is the most complex of all the invertebrates and their brain-to-body-mass ratio falls between ...
Nervous system repair: Upon injury to nerve cells within the central nervous system, astrocytes fill up the space to form a ... As noxious pain is sustained, spinal sensitization creates transcriptional changes in the neurons of the dorsal horn that lead ... They did an experiment to attempt to repair trauma to the Central Nervous System of an adult rat by replacing the glial cells. ... Astrocytes are a sub-type of glial cells in the central nervous system. They are also known as astrocytic glial cells. Star- ...
... serve a variety of functions in the peripheral and central nervous systems. In the peripheral nervous system, TRPs respond to ... Numerous studies have been published investigating the effect of L-menthol application as a model for TRPM8-sensitization. The ... Central nervous system roles of the receptors include neurite outgrowth, receptor signaling, and excitoxic cell death resulting ... Moran MM, Xu H, Clapham DE (June 2004). "TRP ion channels in the nervous system". Curr. Opin. Neurobiol. 14 (3): 362-9. doi: ...
This seems to occur via immune cells interacting with the peripheral nervous system and releasing pain-producing chemicals ( ... December 2004). "Chronic oral Gabapentin reduces elements of central sensitization in human experimental Hyperalgesia". ... "Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human ... Marchand F, Perretti M, McMahon SB (July 2005). "Role of the immune system in chronic pain". Nat. Rev. Neurosci. 6 (7): 521-32 ...
irritation eyes, skin, nose; skin sensitization; narcosis; possible hematopoietic effects; central nervous system depression ...
irritation eyes: conjunctivitis; keratitis (inflammation of the cornea); central nervous system excitement; colored urine, ... nausea, dizziness, suffocation, rapid breath; muscle twitching, delirium; collapse; skin irritation, sensitization, dermatitis ...
... central nervous system depression; dermatitis, skin sensitization ... irritation eyes, skin, respiratory system; headache, dizziness, nausea, incoordination, ...
Eyes, skin, respiratory system, central nervous system Personal Protection/Sanitation. (See protection codes) Skin:Prevent skin ... skin sensitization ... irritation eyes, skin, nose, throat, respiratory system; ...
... central nervous system depression; skin sensitization ...
Eyes, skin, respiratory system, central nervous system, blood Personal Protection/Sanitation. (See protection codes) Skin: ... skin sensitization ... irritation eyes, skin, respiratory system; cough; dizziness, ...
CNS, central nervous system; ANS, autonomic nervous system; PS, peripheral sensitization; CS central sensitization; SP, ... systems throughout the central (upper neuron) and peripheral (lower neuron) nervous system. The "somatic" system is composed by ... John N. Langley coined the terms "autonomic nervous system" and "parasympathetic nervous system" about the turn of the ... the parasympathetic cholinergic system, the sympathetic adrenergic system, and the enteric nervous system (see Goldstein, 2001 ...
... central nervous system depression; skin sensitization Target Organs Eyes, skin, respiratory system, central nervous system ...
irritation eyes, skin, mucous membrane, respiratory system; eye, skin burns; skin sensitization; cough, pulmonary edema; ... Eyes, skin, respiratory system, central nervous system Personal Protection/Sanitation. (See protection codes) Skin:Prevent skin ...
irritation eyes, skin, respiratory system; skin sensitization, dermatitis; lacrimation (discharge of tears), burns eyes; ... Eyes, skin, respiratory system, central nervous system, kidneys Personal Protection/Sanitation. (See protection codes) Skin: ...
irritation eyes, skin; upper respiratory system; skin sensitization; narcosis; possible hematopoietic, reproductive effects; [ ... Eyes, skin, central nervous system, hematopoietic system, reproductive system Cancer Site. [in animals: nasal cancer] ...
Central Nervous System Sensitization. An increased response to stimulation that is mediated by amplification of signaling in ... Unusual relapse of primary central nervous system lymphoma both inside and outside central nervous system in a patient with ... Relapse of primary central nervous system lymphoma (PCNSL) occurs primarily at the initial site, relapse outside central ... Hereditary Central Nervous System Demyelinating Diseases. Inherited conditions characterized by a loss of myelin in the central ...
Eyes, skin, respiratory system, central nervous system, liver Personal Protection/Sanitation. (See protection codes) Skin: ... irritation eyes, skin; dermatitis, sensitization skin; dyspnea (breathing difficulty), lassitude (weakness, exhaustion), ...
Central sensitization: Increased excitability of central nervous system xi . xii GLOSSARY (CNS) neurons and consequent ... Neuraxis: The central nervous system (CNS; the spinal cord and the brain). Nociception: The detection of a noxious event by ... Nocicep- tion represents the peripheral and central nervous system processing of information about the internal or external ... Increased sensitivity and response to a noxious stimulus enhanced by sensitization of peripheral nociceptors and central ...
At high concentrations, it causes hypoactivity, depression of the central nervous system and ataxia. It is a moderate skin ... Chronic toxicity: skin diseases and skin sensitization.. Noticias de seguridad, July 2001, Vol.63, No.7, 4p. Insert.. ... At high repeated concentrations in rats, the substance causes damage to the central nervous system, irritation of the gastro- ... Short-term exposure effects: effects on the central nervous system resulting in unconsciousness. No TLV has been established.. ...
Eyes, skin, respiratory system, central nervous system, kidneys Personal Protection/Sanitation. (See protection codes) Skin: ... irritation eyes, skin, nose, throat; headache, dizziness, convulsions; skin sensitization; hematuria (blood in the urine), ...
Central nervous system. *fatigue. *headache. *lethargy. Ear, Eye, Nose, Throat. *rhinorrhea. Respiratory. *cough ... Use Cautiously in: Known allergies to horse protein (↑ risk of serious hypersensitivity reactions); sensitization may develop ...
Repeated exposure causes skin sensitization and may cause central nervous system and liver damage.[7] ... Acrylonitrile - Integrated Risk Information System, U.S. Environmental Protection Agency. *CDC - NIOSH Pocket Guide to Chemical ...
Background Central sensitization is an important mechanism of chronic migraine (CM) and is related to the inflammatory response ... Considerable evidence from animal models of neuroinflammation suggests that IL-1β of the central nervous system (CNS) is mainly ... Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009;10:895-926.CrossRef ... Central sensitization is an important mechanism of chronic migraine (CM) and is related to the inflammatory response of ...
The substance may have effects on the kidneys, central nervous system and peripheral nervous system. This may result in ataxia ... MAK: (as Hg, inhalable fraction): 0.02 mg/m3; peak limitation category: II(8); skin absorption (H); sensitization of skin (SH ... May cause damage to nervous system and kidneys through prolonged or repeated exposure. Very toxic to aquatic life with long ... Repeated or prolonged contact may cause skin sensitization. ...
Eyes, skin, respiratory system, blood, liver, cardiovascular system, central nervous system, kidneys ... sensitization dermatitis; leukocytosis (increased blood leukocytes); anemia; cardiac irreg ...
Influence of the Gut Microbiome on Autoimmunity in the Central Nervous System. Sara L. Colpitts and Lloyd H. Kasper. J Immunol ... The Influence of the Microbiome on Allergic Sensitization to Food. Catherine H. Plunkett and Cathryn R. Nagler. J Immunol 2017 ... NK Cells in Central Nervous System Disorders. Aurelie Poli, Justyna Kmiecik, Olivia Domingues, Francois Hentges, Mathieu Blery ... Stromal Cell Niches in the Inflamed Central Nervous System. Natalia B. Pikor, Jovana Cupovic, Lucas Onder, Jennifer L. ...
Neuropathic Pain Pain Pathophysiology Nociceptive pain Neuropathic pain Nociceptive Pain Sensitization and activation of ... Peripheral sensitization. Healthy nociceptors. Abnormal nociceptors. CNS. CNS central nervous system Central sensitization ... central sensitization and then reorganization of the pain pathways at the dorsal horn level ... Indicative of CNS sensitization 20. Diagnostic Workup Lab Tests*Complete blood cell count with differential, erythrocyte ...
AFFECTS RESPIRATORY SYSTEM, HEART, SKELETON, CIRCULATORY SYSTEM, CENTRAL NERVOUS SYSTEM AND KIDNEYS. CAUSES IRRITATION TO SKIN ... Maybe cause sensitization by skin contact.. Sodium Fluoride ORL MUS LD50 57mg/kg ORL RAT LD50 52mg/kg SCU RAT LD50 175mg/kg ... Lionel Mandrake: [very nervous] Lord, Jack. General Jack D. Ripper: You know when fluoridation first began? Group Capt. Lionel ...
  • Below the surface of acute bacterial or viral infections lie chronic inflammations, the products of an immune system that is being constantly triggered by overexpressed cytokines. (hindawi.com)
  • The best evidence supports the hypothesis that multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) driven by immune cells targeting myelin antigens. (frontiersin.org)
  • The neuroimmune system and peripheral immune system are structurally distinct. (wikipedia.org)
  • among all the hematopoietic cells of the immune system, only mast cells are normally present in the neuroimmune system. (wikipedia.org)
  • Production of immune cells of the complement system have also been documented as being created directly in the central nervous system. (wikipedia.org)
  • Unlike other hematopoietic cells of the peripheral immune system, mast cells naturally occur in the brain where they mediate interactions between gut microbes, the immune system, and the central nervous system as part of the microbiota-gut-brain axis. (wikipedia.org)
  • medical citation needed] Cytokines have also been implicated in the coordination between the nervous and immune systems. (wikipedia.org)
  • Studies have shown that during times of adaptive immune system response, hippocampal neurogenesis is increased, and conversely that auto-immune T-cells and microglia are important for neurogenesis (and so memory and learning) in healthy adults. (wikipedia.org)
  • The produced action potential is also responsible for the sensation of pain, and the immune system produces IL-1 β as a result of the ATP P2X7 receptor binding. (wikipedia.org)
  • Although inflammation is typically thought of as an immune response, there is an orchestration of neural processes involved with the inflammatory process of the immune system. (wikipedia.org)
  • These supplies are necessary to carry out such metabolic functions as cellular respiration, melanin pigment and connective tissue synthesis, iron metabolism, free radical defense, gene expression, and the normal functioning of the heart and immune systems in infants. (wikipedia.org)
  • These organs and their interactions constitute the HPA axis, a major neuroendocrine system that controls reactions to stress and regulates many body processes, including digestion, the immune system, mood and emotions, sexuality, and energy storage and expenditure. (wikipedia.org)
  • The HPA axis has a central role in regulating many homeostatic systems in the body, including the metabolic system, cardiovascular system, immune system, reproductive system and central nervous system. (wikipedia.org)
  • Tissue grafts are normally recognised as foreign antigen by the body and attacked by the immune system. (wikipedia.org)
  • The nature of isolation of immunologically privileged sites from the rest of the body's immune system can cause them to become targets of autoimmune diseases or conditions, including sympathetic ophthalmia in the eye. (wikipedia.org)
  • These cells interact with the immune system to induce unusual suppression of the systemic immune system response to an antigen introduced into the eye. (wikipedia.org)
  • Sympathetic ophthalmia is a rare disease which results from the isolation of the eye from the systemic immune system. (wikipedia.org)
  • Entering the systemic immune system, these antigens are recognized as foreign and an immune response is mounted against them. (wikipedia.org)
  • The result is the sensitization of immune cells against a self-protein, causing an autoimmune attack on both the damaged eye and the non-damaged eye. (wikipedia.org)
  • In the case of damage or chance presentation to the immune system, the antigen presentation and immune response will occur at elevated rates. (wikipedia.org)
  • these are vital processes that maintain mood, memory, and cognitive performance, and play a large role in the function of the endocrine and immune systems. (wikipedia.org)
  • This seems to occur via immune cells interacting with the peripheral nervous system and releasing pain-producing chemicals (cytokines and chemokines). (wikipedia.org)
  • Frequent and regular physical exercise boosts the immune system[citation needed] and helps prevent certain "diseases of affluence" such as coronary heart disease, type 2 diabetes, and obesity[citation needed]. (wikipedia.org)
  • Physical exercise is important for maintaining physical fitness and can contribute to maintaining a healthy weight, regulating digestive health, building and maintaining healthy bone density, muscle strength, and joint mobility, promoting physiological well-being, reducing surgical risks, and strengthening the immune system. (wikipedia.org)
  • This article describes a case of contact dermatitis in a 31-year-old bricklayer involved in the repair of concrete structures and exposed daily to epoxy systems. (ilo.org)
  • It is based on two earlier theories of MCS: the elevated nitric oxide/peroxynitrite theory and the neural sensitization theory. (ei-resource.org)
  • Finally, multiple hormonal and neural cues (e.g., leptin, estrogen, and serotonin) that use the melanocortin systems to regulate energy and glucose homeostasis will be reviewed. (pubmedcentralcanada.ca)
  • While numerous molecules in the brain and neural structures play key roles in regulating energy and glucose balance and deserve attention, the current review will focus on the central melanocortin system. (pubmedcentralcanada.ca)
  • The method has been successfully employed to reveal functional properties of a number of neural systems, e.g. sensory systems related to touch, pain, and muscle sense as well as sympathetic activity controlling the constriction state of blood vessels. (wikipedia.org)
  • To study nerve impulses of an identified neural system, a fine tungsten needle electrode is inserted into the nerve and connected to a high gain recording amplifier. (wikipedia.org)
  • The exact position of the electrode tip within the nerve is then adjusted in minute steps until the electrode discriminates impulses of the neural system of interest. (wikipedia.org)
  • The reward system is a group of neural structures responsible for incentive salience (i.e., motivation and "wanting", desire, or craving for a reward), associative learning (primarily positive reinforcement and classical conditioning), and positive emotions, particularly ones which involve pleasure as a core component (e.g., joy, euphoria and ecstasy). (wikipedia.org)
  • Despite being harmful, drugs such as nicotine, cocaine, THC, and opium artificially stimulate the emotions and neural circuits involved in the mesolimbic reward system thus encouraging drug consumption. (wikipedia.org)
  • BSR has been found in all vertebrates tested, including humans, and it has provided a useful tool for understanding how natural rewards are processed by specific brain regions and circuits, as well the neurotransmission associated with the reward system. (wikipedia.org)
  • In addition to repeated activity, the increased levels of certain compounds lead to sensitization, as well. (wikipedia.org)
  • Withdrawal from GABAergic-acting sedative-hypnotic drugs causes acute GABA underactivity as well as glutamate overactivity, which can lead to sensitization and hyper-excitability of the central nervous system, excito-neurotoxicity, and increasingly profound neuroadaptions. (wikipedia.org)
  • Pain is always produced by the brain and nervous system, regardless of where you feel it. (bcwomens.ca)
  • Repeated and prolonged occupational overexposure to solvent vapor may cause permanent brain and nervous system damage, and may cause liver or kidney damage. (nih.gov)
  • In humans, the neocortex of the brain has a central role in pain and it has been argued that any species lacking this structure will therefore be incapable of feeling pain. (wikipedia.org)
  • Arthropods have a central brain with three divisions and large optic lobes behind each eye for visual processing. (wikipedia.org)
  • Due to their wide distribution within the nervous system of mammals they play a role in virtually all brain functions. (wikipedia.org)
  • Several scientists and scientific groups have expressed the belief that amphibians can feel pain, however, this remains somewhat controversial due to differences in brain structure and the nervous system compared with other vertebrates. (wikipedia.org)
  • Sensory information arriving at the lateral aspect of the amygdala is processed and conveyed to the central nucleus, which projects to several parts of the brain involved in responses to fear. (wikipedia.org)
  • For this reason, electrical brain stimulation provides a tool for identifying the reward circuitry within the central nervous system with some degree of anatomical and neurochemical specificity. (wikipedia.org)
  • The prefrontal cortex, caudate nucleus, and anterior cingulate cortex are among the most significant brain structures in the dopamine and norepinephrine systems that give rise to cognitive control. (wikipedia.org)
  • Specifically, this tradition postulates that the chemical compounds humans seek out increase brain dopamine levels and thereby effectively usurp the mesolimbic pathway, a system originally intended to motivate/reward fitness enhancing behaviors such as those that increase access to food and sex. (wikipedia.org)