Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)
The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.
Tumors or cancer of the DIGESTIVE SYSTEM.
Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)
A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252)
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
MYCOSES of the brain, spinal cord, and meninges which may result in ENCEPHALITIS; MENINGITIS, FUNGAL; MYELITIS; BRAIN ABSCESS; and EPIDURAL ABSCESS. Certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME).
Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Characteristic properties and processes of the NERVOUS SYSTEM as a whole or with reference to the peripheral or the CENTRAL NERVOUS SYSTEM.
The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Bacterial infections of the brain, spinal cord, and meninges, including infections involving the perimeningeal spaces.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
Neoplasms containing cyst-like formations or producing mucin or serum.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Tuberculosis of the brain, spinal cord, or meninges (TUBERCULOSIS, MENINGEAL), most often caused by MYCOBACTERIUM TUBERCULOSIS and rarely by MYCOBACTERIUM BOVIS. The infection may be limited to the nervous system or coexist in other organs (e.g., TUBERCULOSIS, PULMONARY). The organism tends to seed the meninges causing a diffuse meningitis and leads to the formation of TUBERCULOMA, which may occur within the brain, spinal cord, or perimeningeal spaces. Tuberculous involvement of the vertebral column (TUBERCULOSIS, SPINAL) may result in nerve root or spinal cord compression. (From Adams et al., Principles of Neurology, 6th ed, pp717-20)
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.
Tumors or cancer of the SKIN.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Elements of limited time intervals, contributing to particular results or situations.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
A general term for various neoplastic diseases of the lymphoid tissue.
Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of TOGAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.
Tumors or cancers of the KIDNEY.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures.
MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Injections into the cerebral ventricles.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.
Renewal or physiological repair of damaged nerve tissue.
An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.
Tumors or cancer of the EYE.
Tumors or cancer of the THYROID GLAND.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
DNA present in neoplastic tissue.
Annelids of the class Hirudinea. Some species, the bloodsuckers, may become temporarily parasitic upon animals, including man. Medicinal leeches (HIRUDO MEDICINALIS) have been used therapeutically for drawing blood since ancient times.
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
Tumors or cancer of the LUNG.
Central nervous system vasculitis that is associated with SYSTEMIC LUPUS ERYTHEMATOSUS. Clinical manifestations may include DEMENTIA; SEIZURES; CRANIAL NERVE DISEASES; HEMIPARESIS; BLINDNESS; DYSPHASIA; and other neurological disorders.
An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
Refers to animals in the period of time just after birth.
Tumors or cancer of the PAROTID GLAND.
Tumors or cancer of the LIVER.
The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Clusters of multipolar neurons surrounded by a capsule of loosely organized CONNECTIVE TISSUE located outside the CENTRAL NERVOUS SYSTEM.
Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.
The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.
Tumors or cancer of the APPENDIX.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)
Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.
Tumors or cancer of the ENDOCRINE GLANDS.
A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Infections of the brain, spinal cord, or meninges by single celled organisms of the former subkingdom known as protozoa. The central nervous system may be the primary or secondary site of protozoal infection. These diseases may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
A myelin protein found in the periaxonal membrane of both the central and peripheral nervous systems myelin sheaths. It binds to cells surface receptors found on AXONS and may regulate cellular interactions between MYELIN and AXONS.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
A transmembrane protein present in the MYELIN SHEATH of the CENTRAL NERVOUS SYSTEM. It is one of the main autoantigens implicated in the pathogenesis of MULTIPLE SCLEROSIS.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
A species of CARDIOVIRUS which contains three strains: Theiler's murine encephalomyelitis virus, Vilyuisk human encephalomyelitis virus, and Rat encephalomyelitis virus.
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Formation of NEURONS which involves the differentiation and division of STEM CELLS in which one or both of the daughter cells become neurons.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
Conditions characterized by loss or dysfunction of myelin (see MYELIN SHEATH) in the brain, spinal cord, or optic nerves secondary to autoimmune mediated processes. This may take the form of a humoral or cellular immune response directed toward myelin or OLIGODENDROGLIA associated autoantigens.
Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Neurons which activate MUSCLE CELLS.
Infections of the nervous system caused by fungi of the genus ASPERGILLUS, most commonly ASPERGILLUS FUMIGATUS. Aspergillus infections may occur in immunocompetent hosts, but are more prevalent in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES. The organism may spread to the nervous system from focal infections in the lung, mastoid region, sinuses, inner ear, bones, eyes, gastrointestinal tract, and heart. Sinus infections may be locally invasive and enter the intracranial compartment, producing MENINGITIS, FUNGAL; cranial neuropathies; and abscesses in the frontal lobes of the brain. (From Joynt, Clinical Neurology, 1998, Ch 27, pp62-3)
A circumscribed collection of purulent exudate in the brain, due to bacterial and other infections. The majority are caused by spread of infected material from a focus of suppuration elsewhere in the body, notably the PARANASAL SINUSES, middle ear (see EAR, MIDDLE); HEART (see also ENDOCARDITIS, BACTERIAL), and LUNG. Penetrating CRANIOCEREBRAL TRAUMA and NEUROSURGICAL PROCEDURES may also be associated with this condition. Clinical manifestations include HEADACHE; SEIZURES; focal neurologic deficits; and alterations of consciousness. (Adams et al., Principles of Neurology, 6th ed, pp712-6)
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.

Second-line treatment for primary central nervous system lymphoma. (1/857)

Failure after first-line treatment was reported in 35-60% of immunocompetent patients with primary central nervous system lymphoma (PCNSL). There are currently no reports focusing on salvage therapy. This review analyses prognostic factors and the efficacy of salvage therapy by focusing on data from papers reporting results of first-line treatment in 355 cases. The study group consisted of 173 patients presenting treatment failure. The interval between failure and death (TTD) was compared for age at relapse (< or =60 vs. >60 years), type of failure (relapse vs. progression), time to relapse (< or =12 vs. >12 months) and salvage treatment (yes vs no). Median TTD was similar in younger and older patients (P = 0.09). Relapsed patients had a longer TTD than patients with progressive disease (P = 0.002). Early relapse led to a shorter TTD than late relapse (P = 0.005). Median TTD was 14 months for patients who underwent salvage therapy and 2 months for untreated cases (P<0.00001). A multivariate analysis showed an independent prognostic role for salvage therapy and time to relapse. Age and type of failure had no predictive value. Salvage therapy significantly improves outcome and, possibly, quality of life. As many different treatments were used conclusions cannot be made regarding an optimal treatment schedule.  (+info)

Neurologic complications of systemic cancer. (2/857)

Neurologic complications occur frequently in patients with cancer. After routine chemotherapy, these complications are the most common reason for hospitalization of these patients. Brain metastases are the most prevalent complication, affecting 20 to 40 percent of cancer patients and typically presenting as headache, altered mental status or focal weakness. Other common metastatic complications are epidural spinal cord compression and leptomeningeal metastases. Cord compression can be a medical emergency, and the rapid institution of high-dose corticosteroid therapy, radiation therapy or surgical decompression is often necessary to preserve neurologic function. Leptomeningeal metastases should be suspected when a patient presents with neurologic dysfunction in more than one site. Metabolic encephalopathy is the common nonmetastatic cause of altered mental status in cancer patients. Cerebrovascular complications such as stroke or hemorrhage can occur in a variety of tumor-related conditions, including direct invasion, coagulation disorders, chemotherapy side effects and nonbacterial thrombotic endocarditis. Radiation therapy is the most commonly employed palliative measure for metastases. Chemotherapy or surgical removal of tumors is used in selected patients.  (+info)

Phase II trial of primary chemotherapy followed by reduced-dose radiation for CNS germ cell tumors. (3/857)

PURPOSE: A prospective phase II study was initiated to assess the response rate, survival, and late effects of treatment in patients with newly diagnosed CNS germ cell tumors (GCT), using etoposide plus cisplatin followed by radiation therapy prescribed by extent of disease, histology, and response to chemotherapy. PATIENTS AND METHODS: Seventeen patients aged 8 to 24 years with histologically proven CNS GCT received etoposide (100 mg/m2/d) plus cisplatin (20 mg/m2/d) daily for 5 days every 3 weeks for four cycles, followed by radiation therapy. Nine patients had germinomas; eight had mixed GCT. Four patients (three with germinomas and one with mixed GCT) presented with leptomeningeal dissemination. RESULTS: Radiographically, 14 of 17 patients were assessable for response; 11 patients experienced complete regression, and three had major partial regression before radiation. Six of seven assessable patients with elevated CSF levels of alpha-fetoprotein or betahuman chorionic gonadotropin had normalization with chemotherapy alone; all normalized with combined chemotherapy and radiation therapy. All 17 patients are alive without evidence of disease (median follow-up, 51 months). One patient developed a relapse in the spinal leptomeninges and was rendered free of disease with spinal radiation more than 5 years ago. One patient developed carotid stenosis requiring surgery. Thus far, only minimal long-term deterioration in neurocognitive function has been detected as a consequence of protocol treatment. CONCLUSION: Conventional-dose intravenous chemotherapy with etoposide and cisplatin can effect tumor regression in a high proportion of patients with CNS GCT, including those with leptomeningeal metastases. Acute and long-term toxicities are acceptable. Progression-free survival and overall survival are excellent.  (+info)

Third International Meeting on von Hippel-Lindau disease. (4/857)

Five years after the identification of the von Hippel-Lindau (VHL) gene, physicians, scientists and concerned VHL family members met to review the current state of knowledge on the diagnosis and treatment of VHL and to summarize the latest information on the biochemistry of the VHL protein (pVHL). The NIH and University of Pennsylvania groups reported the detection of germ-line mutations in 100% (93 of 93) of VHL families studied. Several studies determined the frequency of VHL germ-line mutations in individuals with a single manifestation of VHL without a family history of VHL. National groups to improve the diagnosis and treatment of individuals with VHL disease have been established in Great Britain, Denmark, France, Holland, Italy, Japan, Poland, and the United States. Evidence for the existence of genes that modify the expression of VHL was presented. The VHL protein appears to have several distinct functions: (a) down-regulation of hypoxia-inducible mRNAs; (b) proper assembly of the extracellular fibronectin matrix; (c) regulation of exit from the cell cycle; and (d) regulation of expression of carbonic anhydrases 9 and 12.  (+info)

Cancer surveillance series [corrected]: brain and other central nervous system cancers: recent trends in incidence and mortality. (5/857)

BACKGROUND: During the 1980s, the incidence of primary malignant brain and other central nervous system tumors (hereafter called brain cancer) was reported to be increasing among all age groups in the United States, while mortality was declining for persons younger than 65 years. We analyzed these data to provide updates on incidence and mortality trends for brain cancer in the United States and to examine these patterns in search of their causes. METHODS: Data on incidence, overall and according to histology and anatomic site, and on relative survival were obtained from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute for 1975 through 1995. Mortality data were obtained from the National Center for Health Statistics. Medicare procedure claims from the National Cancer Institute's SEER-Medicare database were used for imaging trends. Statistically significant changes in incidence trends were identified, and annual percent changes were computed for log linear models. RESULTS/CONCLUSIONS: Rates stabilized for all age groups during the most recent period for which SEER data were available, except for the group containing individuals 85 years of age or older. Mortality trends continued to decline for the younger age groups, and the steep increases in mortality seen in the past for the elderly slowed substantially. Patterns differed by age group according to the site and grade of tumors between younger and older patients. During the last decade, use of computed tomography scans was relatively stable for those 65-74 years old but increased among those 85 years old or older. IMPLICATIONS: Improvements in diagnosis and changes in the diagnosis and treatment of elderly patients provide likely explanations for the observed patterns in brain cancer trends.  (+info)

V(H) gene sequences from primary central nervous system lymphomas indicate derivation from highly mutated germinal center B cells with ongoing mutational activity. (6/857)

Primary central nervous system lymphoma (PCNSL) represents 1% to 3% intracranial tumors. Most PCNSL are located in the brain, and 75% are large B-cell lymphomas. The largest subgroup of these tumors contains cells that resemble centroblasts and has been labelled diffuse centroblastic (polymorphous) lymphoma. To investigate the cell of origin and the clonal history of these tumors, we have analyzed V(H) gene of 5 cases of PCNSL, all confirmed by histological studies to be Epstein-Barr virus (EBV)-negative, high-grade diffuse B-cell lymphomas. The V4-34 gene of the V(H)4 family was used in 4 of 5 cases. All V(H) genes were found to have accumulated very high levels of somatic mutation (14% to 25%). In 3 of 5 cases, intraclonal nucleotide heterogeneity, including codon deletion in some clones in 1 case, was observed, indicating that the V(H) genes were still under the influence of the somatic hypermutation mechanism. Analysis of the distribution of silent and replacement mutations showed evidence for preservation of immunoglobulin structure in all cases. These results suggest that, although there is no evidence for germinal center formation in the brain tissue, PCNSL is derived from a B cell with features associated with location in a germinal center environment.  (+info)

Association of childhood cancer with factors related to pregnancy and birth. (7/857)

BACKGROUND: It has been hypothesized that risk factors of childhood cancers may already operate during the prenatal and neonatal period. Results of previous epidemiological studies have been inconsistent. METHODS: During 1992-1997 a large case-control study on childhood cancers and a variety of potential risk factors was conducted in Germany. Cases were ascertained by the German Childhood Cancer Registry. Each case was matched to a population-based control of the same age and gender, sampled from the district where the case lived at the date of diagnosis. For the analyses, 2358 cases and 2588 controls were available. RESULTS: Risk of childhood acute leukaemia increased with maternal age < or =20 years at time of delivery (odds ratio [OR] = 1.9, 95% CI: 1.1-3.2), lower (<2500 g: OR = 1.7, 95% CI: 1.1-2.8) and higher birthweight (>4000 g: OR = 1.4, 95% CI: 1.0-1.8, P < 0.05), and hormonal treatment because of infertility (OR = 1.6, 95% CI: 1.0-2.5, P < 0.05). No associations were seen for parental smoking habits, maternal alcohol consumption during pregnancy and fetal losses. Parity was associated only with subgroups of acute leukaemias. Regarding non-Hodgkin's lymphoma we observed an elevated OR for lower birthweight and heavy maternal smoking during pregnancy (>20 cigarettes/day) and a decreased OR for children with one or two siblings. Only a few significant findings were seen for the different groups of solid tumours. CONCLUSIONS: Overall, only weak associations were identified and the evaluated risk factors operating during the neonatal and prenatal period account at most for only a small proportion of childhood cancers.  (+info)

Paucity of leukemic progenitor cells in the bone marrow of pediatric B-lineage acute lymphoblastic leukemia patients with an isolated extramedullary first relapse. (8/857)

Isolated extramedullary relapse in childhood acute lymphoblastic leukemia (ALL) may be accompanied by occult bone marrow disease. We used a highly sensitive assay to quantify leukemic progenitor cells (LPCs) in the bone marrow of such patients. Multiparameter flow cytometry and blast colony assays were used to detect LPCs in the bone marrow of 31 pediatric B-lineage ALL patients with an isolated extramedullary first relapse. Sites of relapse were central nervous system (22 patients), testes (7 patients), and eye (2 patients). Bone marrow (BM) LPC counts ranged from 0/10(6) mononuclear cells (MNCs) to 356/10(6) MNCs (mean +/- SE, 27.8+/-13.1/10(6) MNCs). LPCs were undetectable in 19 patients (61%). The BM LPC burden at the time of extramedullary relapse was similar, regardless of site (Wilcoxon P = 0.77) or time of relapse (Wilcoxon P = 0.80). Compared with higher risk, standard risk at initial diagnosis showed a trend for increased BM LPC burden (mean +/- SE, 44.6+/-17.1 versus 7.5+/-3.3; Wilcoxon P = 0.22). After successful postrelapse induction chemotherapy, LPC counts in 21 evaluated patients ranged from 0/10(6) to 175/10(6) MNCs (mean +/- SE, 15.9+/-9.6/10(6) MNCs). By comparison, LPC burden was higher after successful induction chemotherapy among children with an early BM relapse (range, 0 to 3262/ 106 MNC; mean +/- SE, 166+/-107; Wilcoxon P = 0.11). Thus, not all patients with an extramedullary relapse have occult systemic failure with substantial involvement of the bone marrow, and after reinduction therapy, LPC counts were lower in these patients than in patients treated for an overt BM first relapse.  (+info)

TY - JOUR. T1 - LMO2 and BCL6 are associated with improved survival in primary central nervous system lymphoma. AU - Lossos, Chen. AU - Bayraktar, Soley. AU - Weinzierl, Elizabeth. AU - Younes, Sheren F.. AU - Hosein, Peter. AU - Tibshirani, Robert J.. AU - Sutton Posthumus, Jocelyn. AU - Deangelis, Lisa M.. AU - Raizer, Jeffrey. AU - Schiff, David. AU - Abrey, Lauren. AU - Natkunam, Yasodha. AU - Lossos, Izidore. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Primary central nervous system lymphoma (PCNSL) is an aggressive sub-variant of non-Hodgkin lymphoma (NHL) with morphological similarities to diffuse large B-cell lymphoma (DLBCL). While methotrexate (MTX)-based therapies have improved patient survival, the disease remains incurable in most cases and its pathogenesis is poorly understood. We evaluated 69 cases of PCNSL for the expression of HGAL (also known as GCSAM), LMO2 and BCL6 - genes associated with DLBCL prognosis and pathobiology, and analysed their correlation to survival in 49 PCNSL patients ...
TY - JOUR. T1 - The molecular and phenotypic profile of primary central nervous system lymphoma identifies distinct categories of the disease and is consistent with histogenetic derivation from germinal center-related B cells. AU - Larocca, Luigi Maria. AU - Capello, Daniela. AU - Rinelli, Alessandro. AU - Nori, Simonetta. AU - Antinori, Andrea. AU - Gloghini, Annunziata. AU - Cingolani, Antonella. AU - Migliazza, Anna. AU - Saglio, Giuseppe. AU - Cammilleri-Broet, Sophie. AU - Raphael, Martine. AU - Carbone, Antonino. AU - Gaidano, Gianluca. PY - 1998/8/1. Y1 - 1998/8/1. N2 - Primary central nervous system lymphoma (PCNSL) is a major cause of morbidity and mortality among human immunodeficiency virus (HIV)-infected individuals. The precise histogenetic derivation and the molecular pathogenesis of PCNSL is poorly understood. In an attempt to clarify the histogenesis and pathogenesis of these lymphomas, 49 PCNSL (26 acquired immunodeficiency syndrome [AIDS]-related and 23 AIDS-unrelated) were ...
TY - JOUR. T1 - Primary central nervous system lymphoma. T2 - Phase I evaluation of infusional bromodeoxyuridine with whole brain accelerated fractionation radiation therapy after chemotherapy. AU - Dabaja, Bouthaina S.. AU - McLaughlin, Peter. AU - Ha, Chul S.. AU - Pro, Barbara. AU - Meyers, Christina A.. AU - Seabrooke, Lee F.. AU - Wilder, Richard B.. AU - Kyritsis, Athanassios P.. AU - Preti, H. Alejandro. AU - Yung, W. K.Alfred. AU - Levin, Victor. AU - Cabanillas, Fernando. AU - Cox, James D.. PY - 2003/9/1. Y1 - 2003/9/1. N2 - BACKGROUND. The current study was performed to determine the maximum tolerated dose (MTD), toxicity, and outcome of infusional 5 bromo-2′-deoxyuridine (bromodeoxyuridine; BUdR) given with accelerated fractionation whole brain radiation therapy (WBRT) after chemotherapy for the treatment of primary central nervous system lymphoma (PCNSL). METHODS. Twelve patients with untreated and histologically confirmed PCNSL were entered on the study between 1994 and 1996. ...
RATIONALE: Antiviral drugs such as zidovudine and ganciclovir act against viruses and may be an effective treatment for HIV. Interleukin-2 may stimulate a persons white blood cells to kill lymphoma cells. Combining these treatments may be effective in treating AIDS-related primary central nervous system lymphoma.. PURPOSE: Phase II trial to study the effectiveness of combining zidovudine, ganciclovir, and interleukin-2 in treating patients who have AIDS-related primary central nervous system lymphoma. ...
TY - JOUR. T1 - Case report. T2 - Disorder of excessive somnolence due to central nervous system lymphoma. AU - Lesser, R. P.. AU - St Louis, P.. AU - Dinner, D. S.. AU - Hanson, M.. AU - Little, J. R.. AU - Slugg, P. H.. PY - 1983/1/1. Y1 - 1983/1/1. N2 - We report a patient who developed confusion and recurrent daytime episodes of hypersomnolence. His symptoms proved to be due to a diencephalic primary central nervous system lymphoma, implying that a diencephalic defect in some instances may be involved in the pathogenesis of recurrent sleep attacks.. AB - We report a patient who developed confusion and recurrent daytime episodes of hypersomnolence. His symptoms proved to be due to a diencephalic primary central nervous system lymphoma, implying that a diencephalic defect in some instances may be involved in the pathogenesis of recurrent sleep attacks.. UR - http://www.scopus.com/inward/record.url?scp=0020655405&partnerID=8YFLogxK. UR - ...
Prediction of radiosensitivity in primary central nervous system germ cell tumors using dynamic contrast-enhanced magnetic resonance imaging
Prediction of radiosensitivity in primary central nervous system germ cell tumors using dynamic contrast-enhanced magnetic resonance imaging
Primary central nervous system lymphoma(PCNSL) is a rare kind of non-Hodgkin lymphoma. Rituximab combined with high-dose methotrexate, cytarabine and dexamethasone (R-MAD regimen) were reported effective for PCNSL patients. Rituximab can cause several side effects, including fever, chills and rigors. In this case report, we demonstrate rituximab-induced interstitial pneumonitis in a PCNSL patient who has been treated with R-MAD regimen. The patient recovered after treatment and she remains complete remission after following consolidation chemotherapy. Here is no report of potential fatal complications of Rituximab like interstitial pneumonitis nowadays in PCNSL patients. As Rituximab is widely used, physicians should raise their awareness of this rare complication and detect RTX-ILD in early stage.
TY - JOUR. T1 - Case-based review. T2 - Primary central nervous system lymphoma. AU - Korfel, Agnieszka. AU - Schlegel, Uwe. AU - Johnson, Derek R.. AU - Kaufmann, Timothy J. AU - Giannini, Caterina. AU - Hirose, Takanori. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Primary CNS lymphoma (PCNSL) is a rare diffuse large B-cell lymphoma originating within the central nervous system. The overall incidence of PCNSL is rising, particularly in the elderly population. Immunosuppression is a strong risk factor, but most patients with this tumor are apparently immunocompetent. Diagnosis of PCNSL can be challenging. Non-invasive or minimally invasive tests such as ophthalmological evaluation and spinal fluid analysis may be useful, but the majority of patients require tumor biopsy for definitive diagnosis. Our knowledge concerning optimum treatment of PCNSL is fragmentary due to paucity of adequately sized trials. Most patients are now initially treated with high-dose-methotrexate-based chemotherapy alone, as the ...
The therapeutic response to high-dose methotrexate (HD-MTX) therapy for primary central nervous system lymphoma (PCNSL) varies. Polyglutamylation is a reversible protein modification with a high occurrence rate in tumor cells. MTX incorporated into cells is polyglutamylated and strongly binds to dihydrofolate reductase without competitive inhibition by leucovorin (LV). Tumor cells with high polyglutamylation levels are selectively killed, whereas normal cells with lower polyglutamylation are rescued by LV. We hypothesized that the extent of polyglutamylation in tumor cells determines treatment resistance. Here, we investigated the therapeutic response of PCNSL to HD-MTX therapy with LV rescue based on polyglutamylation status. Among 113 consecutive PCNSL patients who underwent HD-MTX therapy in our department between 2001 and 2014, polyglutamylation was evaluated by immunostaining in 82 cases, with relationships between polyglutamylation and therapeutic response retrospectively examined. Human malignant
This study will evaluate the usefulness of two tests in quickly distinguishing whether a patient with HIV infection and focal brain lesions (an injury in a specific area of the brain) has a rare type of cancer called primary central nervous system lymphoma (PCNSL), or a parasitic infection called toxoplasmic encephalitis.. Toxoplasmic encephalitis is caused by a parasite and can be treated with antibiotics. PCNSL (lymphoma of the brain or spinal cord) must be definitively diagnosed with a brain biopsy (removal of a small piece of brain tissue), and the treatment is radiation therapy and chemotherapy.. The tests under study for diagnosing PCNSL or toxoplasmic encephalitis are measurement of Epstein Barr virus (EBV) DNA in cerebrospinal fluid (CSF) and FDG-PET scan of the brain. EBV is often found in the CSF of people with PCNSL. The study also will compare the accuracy of two imaging techniques-TI-SPECT and FDG-PET-in distinguishing between toxoplasmosis and PCNSL.. Patients 18 years of age and ...
The initial intent of this study was to examine the origins of Primary Central Nervous System Lymphoma (PCNSL), a neoplasm whose oncogenesisin immunocompetentpatients is incompletely understood. With growing information regarding the remarkable plasticity of neural stem cells, and establishment of relationships between hematopoietic and neural stem cells, we hypothesized that PCNSL arises from neural stem/progenitor cells rather than lymphocyte precursors from elsewhere in the body. Markers of neural stem cells were chosen for immunohistochemical(IHC) staining of 5 PCNSL cases and all cases contained Sox2 positive cells, whereas 8 of 9 non-CNS B cell lymphomas so stained had no positive cells. Double-staining with Sox2 and CD20, a B-cell marker, showed no co-localization of Sox2 and CD20, and no CD20-positive tumor cells had Sox2 immunopositivity. Staining of 5 metastatic carcinomas and 1 metastatic melanoma revealed a similar pattern of immunopositivityboth regarding sox2 expression and ...
Each cell in HIV-associated primary central nervous system lymphoma (PCNSL) harbors latent EBV. Notably, the triggering of TLR9, a key event in HIV pathogenesis, also promotes EBV latency and transformation. We hypothesized that because only a minority of HIV-infected patients develops PCNSL, their B cells exhibit aberrant signaling responses to TLR9 triggering. We found higher levels of IL-6, CD80, and CD86 expression at baseline in B cells of those patients than in B cells of matched controls, whereas TNF-a expression was lower. Notably, on TLR9 triggering with CpG 2006, CD80 and TNF- were up-regulated to a lesser extent in B cells of the former than in those of matched controls. The reduced up-regulation of CD80 might be explained by its higher baseline expression resulting in a more blunted response rather than a specific deficit of the signaling response to TLR9 triggering. However, this cannot explain the blunted TNF- response, which warrants further investigation. Finally, since increased ...
Although meningiomas are among the most frequent intracranial tumors, primary central nervous system lymphoma represents a rare variant of extranodal non-Hodgkin-type lymphoma. Here, we report on a 73-year-old man with 2 suspicious intracerebral lesions. Combined DOTATATE PET/CT identif...read more ...
In this article, the authors discuss the principles guiding the use of chemotherapy for primary central nervous system lymphomas.
Fingerprint Dive into the research topics of Diagnosis of primary central nervous system lymphoma: A systematic review of the utility of CSF screening and the role of early brain biopsy. Together they form a unique fingerprint. ...
Doctors at NYU Langone use blood testing, a neurological exam, and imaging tests to diagnose primary central nervous system lymphoma. Learn more.
BACKGROUND: Paternal occupational exposures have been proposed as a risk factor for childhood central nervous system (CNS) tumours. This study investigates possible associations between paternal occupational exposure and childhood CNS tumours in Great Britain. METHODS: The National Registry of Childhood Tumours provided all cases of childhood CNS tumours born and diagnosed in Great Britain from 1962 to 2006. Controls without cancer were matched on sex, period of birth and birth registration sub-district. Fathers occupations were assigned to one or more of 33 exposure groups. A measure of social class was also derived from fathers occupation at the time of the childs birth. RESULTS: Of 11 119 cases of CNS tumours, 5 722 (51%) were astrocytomas or other gliomas, 2 286 (21%) were embryonal and 985 (9%) were ependymomas. There was an increased risk for CNS tumours overall with exposure to animals, odds ratio (OR) 1.40 (95% confidence intervals (CIs) 1.01, 1.94) and, after adjustment for occupational
Central nervous system lymphoma is a rare non-Hodgkin lymphoma in which malignant (cancer) cells from lymph tissue form in the brain and/or spinal cord (primary CNS) or spread from other parts of the body to the brain and/or spinal cord (secondary CNS). Because the eye is so close to the brain, primary CNS lymphoma can also start in the eye (called ocular lymphoma). The cancer can also involve the spinal fluid that bathes the spinal cord and brain. This is called leptomeningeal lymphoma. See Primary Central Nervous System Lymphoma for signs, symptoms and treatments.. ...
TY - JOUR. T1 - Patterns of central nervous system recurrence in patients with systemic human immunodeficiency virus-associated non-Hodgkin lymphoma. AU - Desai, Jigna. AU - Mitnick, Robin J.. AU - Henry, David H.. AU - Llena, Josefina. AU - Sparano, Joseph A.. N1 - Copyright: Copyright 2007 Elsevier B.V., All rights reserved.. PY - 1999/11/1. Y1 - 1999/11/1. N2 - BACKGROUND. Central nervous system involvement is a common manifestation of non-Hodgkin lymphoma (NHL) in human immunodeficiency virus (HIV)-infected individuals. The purpose of this study was to review the frequency and pattern of neurologic manifestation of lymphoma in a cohort of HIV-infected individuals with systemic NHL. METHODS. Sixty-two patients with HIV- associated systemic NHL received infusional cyclophosphamide, doxorubicin, and etoposide. Five patients with lymphomatous meningitis at presentation received whole brain radiation therapy plus intrathecal chemotherapy (ITC). Of the remaining 57 patients, prophylactic ITC was ...
COMBINED MODALITY TREATMENT INCLUDING METHOTREXATE-BASED CHEMOTHERAPY FOR PRIMARY CEREBRAL NERVOUS SYSTEM LYMPHOMA: A SINGLE INSTITUTION EXPERIENCE
View details of top central nervous system lymphoma hospitals in Delhi NCR. Get guidance from medical experts to select best central nervous system lymphoma hospital in Delhi NCR
Response:. Our group published a microarray study of primary central nervous system lymphoma (PCNSL) in Blood in March 2008.1 We reported a comprehensive CNS signature of PCNSL, identifying single-gene differential expression as well as a pathway signature. Most notably, our pathway signature for PCNSL is characterized by differential expression of extracellular matrix (ECM)- and adhesion-related pathways. The most up-regulated gene is the ECM- and adhesion-related osteopontin (SPP1). Our study is unique in that we compared PCNSL to a broad spectrum of non-CNS diffuse large B-cell lymphoma (DLBCL), consisting of nodal and extranodal samples; and in-depth bioinformatics analysis was performed. This is in contrast to 2 other microarray studies in PCNSL2,3 in which the comparisons were made to nodal DLBCL and no pathway analysis was performed.. We are pleased that Rubenstein et al have confirmed our single-gene expression findings by retrospective analysis of their data and come up with concordant ...
Paraffin sections of surgical and autopsy material from 24 cases of primary CNS lymphoma were examined for the presence of cytoplasmic immunoglobulin by an immunoperoxidase technique. Definite staining for cytoplasmic immunoglobulin was observed in 13 cases, and in eight of these the pattern of staining was consistent with current concepts of monoclonality. In every case the histological diagnosis of malignant lymphoma was confirmed, and cases were subclassified by both the Lukes-Collins and the Rappaport classifications. Morphologically 12 of the 24 cases resembled immunoblastic sarcoma occurring outside the CNS. Other cases showed features of follicular center cell lymphoma or plasmacytoid lymphocytic lymphoma. Of those cases with positive immunoglobulin staining of tumor cells, the majority showed some plasmacytoid features. It was concluded that the primary CNS lymphomas resemble their counterparts occurring outside the CNS, and that at least a proportion are derived from the B lymphocyte. ...
Treatment for primary CNS lymphoma includes chemotherapy and often radiation therapy. Steroid therapy (e.g. dexamethasone) is often given before chemotherapy, as this helps reduce the swelling around the tumour, and may even shrink the tumour, reducing the raised intracranial pressure. Chemotherapy is given into a vein, and often also into the fluid surrounding the brain (intrathecally). Methotrexate is the drug most commonly given this way, and is also given in high doses intravenously- either on its own or in combination with other chemotherapy drugs and/or steroids. Radiotherapy uses high-energy rays to destroy the cancerous cells and can be an effective treatment for primary CNS lymphoma in younger people. It is used in combination with chemotherapy and steroid treatment. Surgery is only used to provide diagnostic tissue, and is never curative alone. Anticonvulsants may be given if seizures occur as a result of a tumour. If treatment is insufficient or if the disease recurs, some people are ...
This study is to find the effectiveness of pembrolizumab in patients with relapsed and refractory gray-zone lymphoma (GZL), primary central nervous system
Learn more about Childhood Central Nervous System Embryonal Tumors Treatment (PDQ®) (Patients) from the National Cancer Institute at Siteman Cancer Center.
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:. The main objective of this Cochrane review is to evaluate the role of additional chemotherapy to HD-MTX in the treatment of immunocompetent PCNSL patients with respect to overall survival (OS), progression-free survival (PFS), response rate, adverse events (AE), treatment-related mortality (TRM) and quality of life (QoL). ...
TY - JOUR. T1 - A phase 1 and pharmacokinetic study of enzastaurin in pediatric patients with refractory primary central nervous system tumors. T2 - A pediatric brain tumor consortium study. AU - Kilburn, Lindsay B.. AU - Kocak, Mehmet. AU - Decker, Rodney L.. AU - Wetmore, Cynthia. AU - Chintagumpala, Murali. AU - Su, Jack. AU - Goldman, Stewart. AU - Banerjee, Anuradha. AU - Gilbertson, Richard. AU - Fouladi, Maryam. AU - Kun, Larry. AU - Boyett, James M.. AU - Blaney, Susan M.. N1 - Publisher Copyright: © 2014 The Author(s).. PY - 2015/2/1. Y1 - 2015/2/1. N2 - Background We sought to estimate the maximum tolerated or recommended phase 2 dose and describe the pharmacokinetics and toxicities of enzastaurin, an oral inhibitor of protein kinase Cβ 2, in children with recurrent central nervous system malignancies. Methods Enzastaurin was administered continuously once daily at 3 dose levels (260, 340, and 440 mg/m 2) and twice daily at 440 mg/m 2/day. Plasma pharmacokinetics were evaluated ...
Despite scarce data on surgical treatment of PCNSL, the efforts at resection are generally discouraged. This viewpoint is based on small-scale retrospective studies, which attests that surgical resection per se holds no clear advantages over supportive care. There are a few explanations as to what shaped this outlook. First, PCNSL is an infiltrative tumor with a multifocal nature, which can expand beyond the visible margin of the macroscopic lesion and has a predilection for early wide dissemination [50]. Second, the striking responsiveness to chemotherapy and radiotherapy might have alleviated the desire of invasive procedures against this type of tumor. Another reason could be the improvement of imaging studies, making surgical resection for histologic confirmation unnecessary. Finally, the postoperative morbidity in this patient population could have played a key role in discouraging surgical resection [51].. However, this mindset is not grounded on either randomized data or contemporary ...
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The cell of origin of lymphomas arising in the CNS, a site devoid of normal resident lymphoid tissue, has not been determined. Morphological (4) , immunophenotypic (4) , and molecular genetic (5) studies of PCNSL suggest that the cell of origin is related to the GC. Expression of BCL-6 is one feature that suggests a relationship to the GC. The BCL-6 protein is a zinc-finger transcriptional repressor encoded by the BCL-6 gene (12) . It is required for the formation of the GC (13) . In normal lymphoid tissue, there is nuclear expression of the BCL-6 protein almost exclusively by GC B cells. Lymphomas thought to be derived from GC cells, such as follicular lymphoma, also express BCL-6, whereas lymphomas derived from naïve (chronic lymphocytic leukemia and mantle cell lymphoma) or post-GC (marginal zone lymphomas, myeloma) B cells do not (14 , 15) .. Additional immunophenotypic markers that can aid in the characterization of lymphoid cells with respect to stage of B-cell differentiation were ...
Primary central nervous system lymphoma is a rare neoplasm, exceptionally responsible for developing a frontal lobe syndrome. A 71-years-old patient with primary central nervous system lymphoma had undergone frontotemporal craniotomy for tumor removal. Month later, showing syncopies, disorientation and slurred speech, he was transported to Department of Internal Medicine. Neuroimaging revealed numerous tuberous changes in frontal and parietal lobes and frontotemporal area. During hospitalization, patient exhibited inadequate affect, jocular behaviour, was disoriented in the place and time, and unaware of his health state. He took repeated, uncritical attempts to jump out the window and started to exhibit persecutory delusions and hallucinations. Immediate brain radiotherapy was recommended by the oncology specialists. However, the patient did not consent to the recommended method of treatment due to his lack of recollection of the tumor or the craniotomy. The patient was forcibly transferred to ...
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On page 3201 in the March 15, 2008, issue, the authors omitted the microarray data submission information and accession number. The following sentence should have appeared in Results as the first sentence of the first paragraph under the heading Initial characterization of the microarray data: We have deposited our microarray data in NCBIs Gene Expression Omnibus (Edgar et al, 2002) accessible through GEO Series accession number GSE11392 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc = GSE11392).. ...
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The present invention relates to primary CNS tumors and provides useful compositions and methods for reducing tumor volume and increasing the length of survival in mammals with primary CNS tumors, thereby providing a treatment for primary CNS tumors. The invention also relates to methods of identifying compounds for reducing tumor volume and increasing animal survival, which therefore relate to treating primary CNS tumors.
PAZZI, Paolo; TOMPKINS, Samantha and KIRBERGER, Robert M. Canine spirocercosis-associated extraskeletal osteosarcoma with central nervous system metastasis. J. S. Afr. Vet. Assoc. [online]. 2013, vol.84, n.1, pp.00-00. ISSN 2224-9435.. A five-year-old male Boerboel presented for examination, collapsed for an unknown period of time. On clinical examination, multifocal subcutaneous masses and enlarged prescapular lymph nodes as well as neurological deficits that suggested a multifocal neurological syndrome were found. Fine needle aspirates of the prescapular lymph nodes revealed cells suggestive of osteosarcoma. Radiographs showed foci of mineralisation within the soft tissue masses as well as diffuse pulmonary metastasis and a caudodorsal mediastinal mass believed to be a Spirocerca lupi nodule. Computed tomography imaging, necropsy and histopathology confirmed S. lupi oesophageal neoplastic transformation (extraskeletal osteosarcoma), believed to be the primary lesion, and the majority of ...
The following institutions and clinicians participated in the study: Hospital Universitari Germans Trias i Pujol, Badalona (J. M. Ribera, J. M. Sancho, A. Oriol, and E. Feliu); Hospital Carlos Haya, Malaga (C. Bethencourt); Hospital Virgen del Rocio, Sevilla (R. Parody); Hospital Virgen de la Victoria, Malaga (M. J. Moreno and M. J. Queipo de Llano); Hospital Clinico Universitario, Salamanca (J. M. Hernandez-Rivas); Hospital Clinico San Carlos, Madrid (E. del Potro); Hospital General, Alicante (C. Rivas and P. Fernandez-Abellan); Hospital Clinico Universitario, Valencia (M. Tormo and M. J. Terol); Hospital Son Dureta, Palma de Mallorca (J. Besalduch and A. Novo); Hospital Universitario La Fe, Valencia (M. A. Sanz and F. Moscardo); Hospital Xeral, Lugo (J. Arias); Hospital Morales Meseguer, Murcia (J. M. Moraleda and I. Heras); Hospital Vall dHebron, Barcelona (J. Bueno and J. J. Ortega); Hospital Clinico, Valladolid (J. Fernandez-Calvo and D. Borrego); Hospital Puerta del Mar, Cadiz (V. ...
In this retrospective multicentre study, we investigated the outcomes of elderly primary central nervous system lymphoma (PCNSL) patients (greater than or equal to65 years) who underwent high-dose chemotherapy followed by autologous stem cell transplantation (HDT-ASCT) at 11 centres between 2003 and 2016. End points included remission, progression-free survival (PFS), overall survival (OS) and treatment-related mortality. We identified 52 patients (median age 68.5 years, median Karnofsky Performance Status before HDT-ASCT 80%) who all underwent thiotepa-based HDT-ASCT. Fifteen patients (28.8%) received HDT-ASCT as first-line treatment and 37 (71.2%) received it as second or subsequent line. Remission status before HDT-ASCT was: CR 34.6%, PR 51.9%, stable disease 3.8% and progressive disease 9.6%. Following completion of HDT-ASCT, 36 patients (69.2%) achieved CR (21.2% first-line setting and 48.1% second or subsequent line setting) and 9 (17.3%) PR (5.8% first-line setting and 11.5% second or subsequent
Named to the Top 10 Honor Roll on U.S. News & World Reports 2016-17 list of Americas Best Childrens Hospitals, Nationwide Childrens Hospital is Americas largest not-for-profit freestanding pediatric healthcare system providing wellness, preventive, diagnostic, treatment and rehabilitative care for infants, children and adolescents, as well as adult patients with congenital disease. Nationwide Childrens has a staff of more than 11,000 providing state-of-the-art pediatric care during more than 1.2 million patient visits annually. As home to the Department of Pediatrics of The Ohio State University College of Medicine, Nationwide Childrens physicians train the next generation of pediatricians and pediatric specialists. The Research Institute at Nationwide Childrens Hospital is one of the Top 10 National Institutes of Health-funded freestanding pediatric research facilities. More information is available at NationwideChildrens.org ...
Investigator] Aghakhani N; Ali Benali M; Alliez B; Amat D; Amlashi A; Arbez-Gindre F; Arbion F; Assaker R; Aubriot Lorton MH; Auque J; Autricque A; Auvigne I; Averous G; Baldet P; Bataille B; Bazin A; Beaurain J; Benezech J; Bergemer Fouquet A; Besson G; Beuvon F; Billotet C; Blond S; Boetto S; Boissonnet H; Bonyhay G; Bouillot P; Bourgeois P; Bouvier C; Brassier G; Broche C; Brunon J; Cabal P; Cahn V; Caire F; Calvet P; Cazals-Hatem D; Chapon F; Chazal J; Civit T; Colnat S; Colombat M; Comoy J; Couvelard A; Czorny A; Dam Hieu P; Daumas-Duport C; Dautheribes M; David P; Debono B; Delage Corre M; Delhaye M; Delisle MB; Delsol G; Derlon JM; Desenclos C; Desplat A; Devaux B; Di Rocco F; Diaz A; Diebold MD; Dorfmuller G; Dran G; Dufour T; Dumas B; Dumollard JM; Durand L; Duthel R; Eimer S; El Fertit H; Emery E; Espagno C; Esposito P; Etchandy MP; Eyremandi RP; Faillot T; Felix S; Fernandez C; Fesselet J; Fontaine D; Fournier D; François P; Froelich S; Fuentes JM; Fuentes S; Gadan R; Gaspard C; Gay ...
TY - JOUR. T1 - Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies. AU - Choi, John. AU - Rui, Yuan. AU - Kim, Jayoung. AU - Gorelick, Noah. AU - Wilson, David R.. AU - Kozielski, Kristen. AU - Mangraviti, Antonella. AU - Sankey, Eric. AU - Brem, Henry. AU - Tyler, Betty. AU - Green, Jordan J.. AU - Jackson, Eric M.. PY - 2020/1. Y1 - 2020/1. N2 - Together, medulloblastoma (MB) and atypical teratoid/rhabdoid tumors (AT/RT) represent two of the most prevalent pediatric brain malignancies. Current treatment involves radiation, which has high risks of developmental sequelae for patients under the age of three. New safer and more effective treatment modalities are needed. Cancer gene therapy is a promising alternative, but there are challenges with using viruses in pediatric patients. We developed a library of poly(beta-amino ester) (PBAE) nanoparticles and evaluated their efficacy for plasmid delivery of a suicide gene therapy to pediatric brain cancer ...
TY - CHAP. T1 - Blood-Brain Barrier Disruption Chemotherapy. AU - McGregor, John M.. AU - Bell, Susan D.. AU - Doolittle, Nancy. AU - Murillo, Tulio P.. AU - Neuwelt, Edward. PY - 2018/4/24. Y1 - 2018/4/24. N2 - The goal of chemotherapy administered in conjunction with blood-brain barrier disruption (BBBD) is maximizing drug delivery to the brain, while preserving the neurocognitive function and minimizing systemic toxicity. In the clinic, BBBD has shown promising results in chemosensitive brain tumors such as the primary central nervous system lymphoma (PCNSL) and offers a new strategy for global delivery of chemotherapy to tumors such as anaplastic oligodendroglioma and central nervous system metastases. Multicenter clinical trials using BBBD are in progress at centers participating in the blood-brain barrier (BBB) Consortium. Current and future clinical studies include delivery of mAbs across the BBB and novel imaging agents to monitor therapeutics.. AB - The goal of chemotherapy administered ...
Induction chemotherapy. High dose Methotrexate: The efficacy of Methotrexate in the treatment of Primary CNS lymphoma was first demonstrated by Ervin & Canellos in 1980 [17]. The primary CNS lymphoma cells inside brain are more sensitive to MTX and thus HD-MTX forms the backbone of PCNL therapy. HD-MTX is also shown a treatment related prognostic marker for survival in these patients [18]. There is no firm definition of HD-MTX and doses from 1g/m2 to 8 g/m2 has been reported in clinical trials [19]. Importantly Lippens and colleagues [20] demonstrated that intravenous administration of Methotrexate over 3 hours (3g/m2) leads to superior concentrations in cerebrospinal fluid (CSF) than infusion over 24 hours. Despite detectable meningeal disease in up to 15 % patients at diagnosis, intrathecal therapy has failed to achieve significantly better outcome [21]. Glantz et al demonstrated higher CSF levels after intravenous Methotrexate (8g/m2) than intrathecal injection with 12g/m2 Methotrexate [16]. ...
Mutations in SETD2 are found in many tumors, including central nervous system (CNS) tumors. Previous work has shown these mutations occur specifically in high grade gliomas of the cerebral hemispheres in pediatric and young adult patients. We investigated SETD2 mutations in a cohort of approximately 640 CNS tumors via next generation sequencing; 23 mutations were detected across 19 primary CNS tumors. Mutations were found in a wide variety of tumors and locations at a broad range of allele frequencies. SETD2 mutations were seen in both low and high grade gliomas as well as non-glial tumors, and occurred in patients greater than 55 years of age, in addition to pediatric and young adult patients. High grade gliomas at first occurrence demonstrated either frameshift/truncating mutations or point mutations at high allele frequencies, whereas recurrent high grade gliomas frequently harbored subclones with point mutations in SETD2 at lower allele frequencies in the setting of higher mutational burdens.
University of Occupational and Environmental Health, Department of Neurosurgery, Kitakyushu, Japan DOI : 10.5137/1019-5149.JTN.10594-14.1 5-Aminolevulinic acid (5-ALA)-induced fluorescence-guided resection is a widely used procedure for patients with malignant gliomas. However, the clinical application of 5-ALA for surgery in primary central nervous system lymphoma (PCNSL) is uncommon. Here, we present a case of PCNSL treated using 5-ALA-induced fluorescence-guided resective surgery. A 70-year-old woman presented with cerebellar ataxia, and magnetic resonance imaging revealed an irregularly shaped and homogenously enhanced mass with surrounding brain edema in the vermis that extended to the right hemisphere of the cerebellum. Under the preoperative diagnosis of a malignant glioma in the cerebellum, the patient underwent 5-ALA-induced fluorescence-guided surgery. Under blue light illumination, the tumor revealed strong 5-ALA-induced fluorescence. The tumor was identified as a diffuse large B-cell ...
The results of genetic association studies regarding cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) polymorphisms and digestive system malignancies were controversial. The authors designed this meta-analysis to more precisely estimate relationships between CTLA-4 polymorphisms and digestive system malignancies by pooling the results of related studies. The authors searched PubMed, Embase, Web of Science, and CNKI for eligible studies. Thirty-one eligible studies were pooled analyzed in this meta-analysis. The pooled meta-analysis results showed that genetic distributions of rs231775, rs4553808, and rs733618 polymorphisms among patients with digestive system malignancies and controls differed significantly. Moreover, genotypic distribution differences were also observed for rs231775 polymorphism among patients with colorectal cancer/pancreatic cancer and controls, for rs4553808 and rs5742909 polymorphisms among patients with gastric cancer and controls, for rs3087243 polymorphism among patients
TY - JOUR. T1 - The potential for complete and durable response in nonglial primary brain tumors in children and young adults with enhanced chemotherapy delivery. AU - Dahlborg, Suellen A.. AU - Petrillo, Annie. AU - Crossen, John R.. AU - Roman-Goldstein, Simon. AU - Doolittle, Nancy D.. AU - Fuller, Kristi H.. AU - Neuwelt, Edward A.. PY - 1998. Y1 - 1998. N2 - PURPOSE: Radiographic tumor response and survival were evaluated in the pediatric and young adult population with germ cell tumor, primary CNS lymphoma, or primitive neuroectodermal tumor receiving intra-arterial carboplatin- or methotrexate-based chemotherapy with osmotic blood-brain barrier disruption (BBBD). PATIENTS AND METHODS: Thirty-four patents with histologically confirmed germ cell tumor (n = 9), primary CNS lymphoma (n = 9), or primitive neuroectodermal tumor (n = 16) were treated at the Oregon Health Sciences University from August 1981 through April 1995. Ages ranged from 1 to 30 years (mean, 18 years). Prior treatments ...
My mom (only 54 years old) has Primary Central Nervous System Lymphoma. She has undergone various chemo treatments for over three years. Now, there is no sign of the tumor, but she is suffering great losses due to the treatment. In the last 6 months my moms congnitive abilities have drastically declined. She has completely lost her short-term memory, she can no longer express herself verbally (inability to recall words), she is easily agitated, and very depressed. All of these symptoms/reactions are devastating to my mom and our family. Clearly, she can no longer live on her own or care for herself. Right now, we are looking into nursing/assisted living care facilities. Has anyone else suffered such huge losses due to chemo treatment? What did you do? Does any form of detox help? Also, does anyone have recommendations for nursing/assisted living facilities (for cancer survivors or individuals with severe brain impairments) in the Los Angeles and/or San Diego area? Thanks for your help. ...
Retrospective, single-practice data analysis from a medical record system. Forty-one eyes of 31 patients, in which diagnostic or therapeutic vitrectomy was performed for VO between April 2012 and March 2015 in National Defense Medical College, were reviewed. Twelve eyes of 10 patients were infectious uveitis (males/females; 5/5, average age ± standard deviation; 71.8 ± 10.8 years old, primary top 3 diseases; endophthalmitis 5 eyes, cytomegalovirus retinitis 3 eyes, acute retinal necrosis 1 eye, ocular toxoplasmosis 1 eye), and 29 eyes of 21 patients were noninfectious uveitis (males/females; 3/18, average age; 64.0 ± 12.2 years old, primary top 3 diseases; sarcoidosis 9 eyes, primary central nervous system lymphoma 4 eyes, Behcets disease 2 eyes). BCVA before surgery and at 1, 3, and 6 months after surgery were converted to logMAR, and improvement rate of logMAR were evaluated by the ratio of postoperative logMAR to preoperative logMAR at the individual time points ...
The Oxford Textbook of Neuro-Oncology examines the epidemiology, pathogenesis, clinical features, and management of adult and childhood central nervous system (CNS) tumours. The book is organized according to the World Health Organization (WHO) classification of CNS tumours and includes an introductory chapter discussing the new, revised WHO classification that will be used in future editions of this textbook. The book reviews primary CNS tumours, metastatic CNS tumours, and familial tumour syndromes. Each chapter is organized according to a uniform framework, addressing epidemiology, aetiology, pathogenesis, clinical presentation, imaging, and treatment, with a focus on different treatment modalities and specific consideration of paediatric aspects, where applicable. Each chapter is authored by a multidisciplinary, international group of senior specialists representing the United States, Canada, Europe, and the Asia/Pacific region. It is written for generalists and specialists managing these ...
High levels of AGAT activity are common in adult brain tumors (12, 13, 14) and may be correlated with poor responses to alkylator-based chemotherapy and decreased time to treatment failure and death (12 , 15 , 16) . High levels of AGAT have also been observed in pediatric brain tumors, including gliomas, medulloblastomas, primitive neuroectodermal tumors, and ependymomas (13) . These observations may explain why nitrosourea-based chemotherapy has had little impact on survival in common pediatric brain tumors (17 , 18) . Therefore, a strategy to inactivate AGAT before administration of an aklyating agent is a logical pursuit for adult and pediatric central nervous system tumors.. We found that O6BG is rapidly eliminated with a half-life of 85 ± 140 min after i.v. administration. In contrast 8-oxo-O6BG, an active metabolite, appears rapidly in plasma after O6BG administration and has a prolonged half-life of approximately 6 h. In most patients, the combined concentrations of O6BG and 8-oxo-O6BG ...
Neurolymphomatosis (NL) is a rare clinical entity. The International Primary CNS Lymphoma Collaborative Group retrospectively analyzed 50 patients assembled from 12 centers in 5 countries over a 16-year period. NL was related to non-Hodgkin lymphoma in 90% and to acute leukemia in 10%. It occurred as the initial manifestation of malignancy in 26% of cases. The affected neural structures included peripheral nerves (60%), spinal nerve roots (48%), cranial nerves (46%), and plexus (40%) with multiple site involvement in 58%. Imaging studies often suggested the diagnosis with 77% positive magnetic resonance imaging, and 84% (16 of 19) positive computed tomography-positron emission tomography studies. Cerebrospinal fluid cytology was positive in 40%, and nerve biopsy confirmed the diagnosis in 23 of 26 (88%). Treatment in 47 patients included systemic chemotherapy (70%), intra-cerebrospinal fluid chemotherapy (49%), and radiotherapy (34%). Response to treatment was observed in 46%. The median overall ...
Objective. To describe the treatment and outcomes of patients with primary central nervous system (CNS) vasculitis. Methods. We retrospectively studied a cohort of 163 consecutive patients with primary CNS vasculitis who were seen at the Mayo Clinic over a 29-year period. We analyzed treatments, treatment responses, and factors predictive of outcomes. Results. A favorable response was observed in 85% of patients treated with prednisone alone and in 80% of patients treated with prednisone and cyclophosphamide. Relapses were observed in 27% of patients, and 25% of patients had discontinued therapy by the time of the last followup visit. Treatment with prednisone alone was associated with more frequent relapses (odds ratio [OR] 2.90), while large vessel involvement (OR 6.14) and cerebral infarcts at the time of diagnosis (OR 3.32) were associated with a poor response to treatment. Prominent gadolinium-enhanced cerebral lesions or meninges were linked with continued treatment at the last followup ...
TY - JOUR. T1 - Unilateral chronic relapsing primary central nervous system vasculitis. AU - Salvarani, Carlo. AU - Brown, R. D.. AU - Morris, J. M.. AU - Huston, J.. AU - Hunder, G. G.. PY - 2014. Y1 - 2014. UR - http://www.scopus.com/inward/record.url?scp=84901917691&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84901917691&partnerID=8YFLogxK. M3 - Letter. C2 - 24528778. AN - SCOPUS:84901917691. VL - 32. SP - S139-S140. JO - Clinical and Experimental Rheumatology. JF - Clinical and Experimental Rheumatology. SN - 0392-856X. IS - SUPPL.82. ER - ...
Central nervous system (CNS) lymphoma is a condition in which malignant cells are present in the lymph tissue of the brain and/or spinal cord. Treatment for CNS lymphoma generally does not include surgery. Instead, nonsurgical treatments, namely corticosteroids, chemotherapy and/or whole-brain radiation therapy, are used to treat CNS lymphoma.. Lymphoma designates a group of cancers that arise from white blood cells called lymphocytes. Because lymphocytes travel in the blood and lymph tissue and pass in and out of the CNS, lymphoma too can develop in various places in the body, including the CNS. CNS lymphoma is an aggressive type of lymphoma.. CNS lymphoma comes in two forms, depending on the origin of the tumor, and can produce single or multiple growths. ...
Primary central nervous system (CNS) lymphoma is a disease in which malignant (cancer) cells form in the lymph tissue of the brain and/or spinal cord. Lymphoma is a disease in which malignant (cancer) cells form in the lymph system. The lymph system is part of the immune system and is made up of the lymph, lymph...
CNS lymphoma refers to the involvement of the central nervous system with lymphoma. It can be broadly divided into primary and secondary, with a number of special types of also recognised. primary CNS lymphoma (PCNSL) intravascular lymphoma M...
Childhood central nervous system (CNS) germ cell tumors form from germ cells (a type of cell that forms as a fetus develops and later becomes sperm in the testicles or eggs in the ovaries). Learn about the signs, tests to diagnose, and treatment of pediatric germ cell tumors in the brain in this expert-reviewed summary.
Per usion is started in all children including neonates, complete seizure 30 viagra at reedom in o patients. Patients often present insidiously. New york cambridge university press. Other common adverse effects eg, weight loss, exercise, and behavior o the disease. Such testing is commonly disrupted among migraineurs. Case critically ill neonates iv= intravenous cns =central nervous system metastases has been shown for pediatric ophthalmology and strabismus. Patients who are trained in neurology is consulted and opt or conservative use of oral or iv ergotamine agents are much more hypoechoic than the usual dose of aeds should be used for the treatment of adhd medication should be. Many di erent classes at the receptor site include alterations in blood pressure goal for a treatment disadvantage. The cells are contained in endogenous estrogen, bone remodeling accelerates during menopause, and up to once daily twice daily fish oil are only appropriate for occasional moderatesevere flares or ...
Study 3 was a multicenter, open-label trial that randomized (1:1) patients with mCRC who were previously untreated in the metastatic setting and who had received no prior oxaliplatin to receive Panitumumab every 14 days in combination with FOLFOX or to FOLFOX alone every 14 days. Panitumumab was administered at 6 mg/kg over 60 minutes prior to administration of chemotherapy. The FOLFOX regimen consisted of oxaliplatin 85 mg per m2 IV infusion over 120 minutes and leucovorin (dl-racemic) 200 mg per m2 intravenous infusion over 120 minutes at the same time on day 1 using a Y-line, followed on day 1 by 5-FU 400 mg per m2 intravenous bolus. The 5FU bolus was followed by a continuous infusion of 5-FU 600 mg per m2 over 22 hours. On day 2, patients received leucovorin 200 mg per m2 followed by the bolus dose (400 mg per m2) and continuous infusion of 5FU (600 mg per m2) over 22 hours. Study 3 excluded patients with known central nervous system metastases, clinically significant cardiac disease, ...
AT/RTs are rare malignant intracranial tumors, representing only 1.3% of primary CNS tumors in the pediatric population and 6.7% of CNS tumors in children younger than 2 years.2 Malignant rhabdoid tumors can occur in many locations in the body, though the kidney and CNS are the most common primary sites.3 Within the CNS, 38%-65% have been reported to be infratentorial, 27%-62% in supratentorial locations, and 4%-8% occurring in multiple CNS sites at diagnosis.1,3,9. Rhabdoid cells in AT/RT observed with light microscopy are often plump with eccentric round nuclei containing prominent nucleoli within fibrillary or granular eosinophilic cytoplasm, though rhabdoid tumor cells can also be small and spindle-shaped with ovoid nuclei or large, containing nuclei with wrinkled margins.1,3,5,11 Abundant mitotic figures, necrosis, hemorrhage, and ill-defined margins with adjacent brain are common histologic feature seen in AT/RT.1,3,5,11 In addition to the rhabdoid tumor cells, intracranial AT/RTs often ...
The brain is the center of thought, memory, emotion, speech, sensation and motor function. The spinal cord and special nerves called cranial nerves carry and receive messages between the brain and the rest of the body. Brain tumors cause damage because, as they grow, they can interfere with surrounding cells that serve vital roles in our everyday life.. The Central Brain Tumor Registry of the United States estimates that more than 688,096 persons are living with a diagnosis of primary brain and central nervous system tumors in the United States.. An estimated 77,670 new cases of primary benign and malignant brain and central nervous system tumors are expected to be diagnosed in the United States in 2017.. ...
In January 2016, Sarah Rosenfeld had such severe pain shooting down her legs she couldnt walk, sleep or care for her young daughters. After weeks of physical therapy for what she thought was sciatica, she had an MRI. Thirty-seven-year-old Rosenfeld learned she had something far worse: myxopapillary ependymoma, a rare cancerous tumor in her spinal cord. She came to the NIH for
CSF cytology via lumbar puncture: If the primary tumor was exposed to the CSF compartment (or arose in it), lumbar CSF should be examined for cytology 7-14 days after surgery to exclude CSF dissemination unless there was preoperative evidence of leptomeningeal disease. ...
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively ...
ImmunoChemistry Technologies. In this webinar, learn how escaping immune system surveillance is a major obstacle for immunotherapies against cancer. Tumor cells secrete soluble factors allowing them to escape immune surveillance. Exosomes, or small vesicular structures excreted by normal cells, have a plethora of biological significance as these exosomes play a significant role in intracellular communication and help in the activation of immune response. However, in the case of cancer, exosomes secreted by tumor cells can induce apoptosis of activated T cells or impair the differentiation of monocytes to myeloid derived suppressor cells. We found out that tumor derived exosomes inhibit antigen specific proliferation and induce B cell hyperactivation, but are functionally suppressed. We also investigated whether TLR4 mediated signaling has a major role in this immune suppression.. ...
Primary CNS lymphomas (PCNSL) are defined as extranodal lymphomas arising within the CNS in the absence of lymphoma outside the CNS at the time of diagnosis. PCNSL in immunocompetent individuals are rare and account for approximately 5% of all brain tumors and , 1% of Non-Hodgkin lymphomas. Males are affected more than females with a ratio of 3:2 [1,2]. Immunodeficiency disorders such as Wiskott-Aldrich and AIDS predispose to the development of PCNSL. The Epstein-Barr virus (EBV) genome is found in more than 95% of immunocompromised patients and only in 0-20% of immunocompetent patients [2]. Most patients present with focal neurological deficits and around 5-20% present with seizures. MRI is the most sensitive radiologic modality for the detection of CNS lymphomas. It characteristically shows single or multiple enhancing lesions which can be seen in other brain lesions such as glioblastomas, brain abscesses, and metastatic carcinomas ...
Controversy #3: Should all patients receive intrathecal prophylaxis for central nervous system disease?. A clinical dilemma is whether these patients require central nervous system (CNS) prophylaxis. Multiple cases of an increased incidence of CNS involvement have been reported. A small study described 40 patients with DLBCL with leukemic-phase disease, 14 of whom had CNS disease. Eight of these patients had FISH-confirmed double-hit lymphoma. In logistic regression analysis, double-hit status was found to be the one independent factor correlated with CNS involvement.19 In the MD Anderson experience, the incidence of CNS involvement at diagnosis was 4%, with a cumulative incidence of CNS involvement of 13% at 3 years. In patients who did not have documented CNS disease at the time of diagnosis, the incidence of eventual CNS involvement was lower. in those receiving prophylactic intrathecal therapy (5% at 3 years) than in those who did not (15% at 3 years; P =.017).8 At this time, secondary to ...
Immunotherapy advances for glioblastoma Neuro-Oncology - current issue Survival for patients with glioblastoma, the most common high-grade primary CNS tumor,
Between 1986 and 1990, four children with recurrent CNS leukemia who had previous CNS prophylaxis therapy were treated with intermittent central nervous system irradiation and intrathecal chemotherapy (IIIC). There was no isolated CNS recurrence. One patient died form bone marrow relapse. Three patients are alive without evidence of disease for 3E3/12 year to 3E6/12 year after the diagnosis of recurrence of CNS leukemia. This experience suggests that IIIC may be an effective treatment for preventing the recurrence of CNS leukemia without any serious side effects. ...
Central Nervous System (CNS) relapses and Secondary CNS Lymphoma - A.J.M. Ferreri presents treatment regimens for these patients in a multidisciplinary cases session at ESMO 2016
R-MPV is most often associated with treatment of CNS Lymphoma. Drugs involved: Rituximab, Methotrexate, Leucovorin, Procarbazine, Vincristine
The diagnosis of lymphoma is not always straight forward, and in this case it remains difficult to know whether the two processes were coincidental or more likely related to each other. Demyelination preceding a CNS lymphoma is a recognised phen...
Results Of 218 patients post-trial follow-up data were available. The maximum follow-up time was 11.8 years. Fewer patients initiated a first bDMARD in the former MTX+pred compared with the former MTX+plac strategy group: 31% vs 50%, p=0.003. At the 2 year post-trial follow-up, the median erosion score was significantly lower in the former MTX+pred versus former MTX+plac strategy group: 0 (range 0-0) versus 0 (0-2), p=0.002. No significant differences between the former strategy groups in the onset of GC-related comorbidities during the post-trial follow-up were found. ...
Cancer, Risk, Survivors, Screening, Health, Acute Lymphoblastic Leukemia, Leukemia, Lymphoblastic Leukemia, Treatment, Children, Neoplasms, and Radiotherapy
by Ferreri, A. J.M and Dognini, G. P and Campo, E and Willemze, R and Seymour, J. F and Bairey, O and Martelli, M and De Renzo, A and Doglioni, C and Montalban, C and Tedeschi, A and Pavlovsky, A and Morgan, S and Uziel, L and Ferracci, M and Ascani, S and Gianelli, U and Patriarca, C and Facchetti, F and Dalla Libera, A and Pertoldi, B and Horvath, B and Szomor, A and Zucca, E and Cavalli, F and Ponzoni, M and on behalf of the International Extranodal Lymphoma Study Group (IELSG) and International Extranodal Lymphoma Study Group (IELSG) and IELSG Grp ...
Primary Cns Lymphoma in Immunocompetent: A Review of Literature and Our Experience from Kashmir Rumana MAKHDOOMI, Khursheed NAYIL, Ahmad RAYEES, Altaf KIRMANI, Altaf RAMZAN, Muhammad Baba KHALIL, Anil DHAR, Syed BESINA, Nasima CHANDA, Abdul Rashid LONE, Sumaira QADIRI, Muhammad MAQBOOL Abstract ...
During the past decade it has been frequently observed that patients with breast cancer treated with a taxane-containing chemotherapy regimen, either in the adjuvant setting or in the metastatic setting, presenting central nervous system (CNS) involvement as the only evidence of disease progression. More studies were therefore interested to evaluate the incidence of CNS metastases in patients with early and advanced breast cancer treated with a taxane-containing chemotherapy regimen and to
Panelists Suresh S. Ramalingam, MD, and Giorgio Scagliotti, MD, PhD, describe the prevalence of CNS metastases and the approach to management in patients with |em|EGFR|/em|-positive non–small cell lung cancer.
The mean annual incidence of children with CNS tumours was 4.2/100,000 and has not increased during the study period. Survival rate for brain tumours at 10 years follow-up was 72%.. ...
"A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option". ... However, metastasis of GBM beyond the central nervous system is extremely unusual. About 50% of GBMs occupy more than one lobe ... It is the second most common central nervous system cancer after meningioma. The term glioblastoma multiforme was introduced in ... Stevens, Glen H. J. (2006). "Antiepileptic therapy in patients with central nervous system malignancies". Current Neurology and ...
Central precocious puberty can be caused by intracranial neoplasm, infection (most commonly central nervous system tuberculosis ... Causes of central precocious puberty can include: damage to the inhibitory system of the brain (due to infection, trauma, or ... 2013). "Central precocious puberty caused by mutations in the imprinted gene MKRN3". N Engl J Med. 368: 2467-2475. doi:10.1056/ ... 2014). "Central precocious puberty that appears to be sporadic caused by paternally inherited mutations in the imprinted gene ...
They look like intracranial neoplasms, and sometimes they get biopsied as suspected tumors. Proton MR spectroscopy can help in ... However, in a person with MS, these cells recognize healthy parts of the central nervous system as foreign and attack them as ... Multiple sclerosis and other demyelinating diseases of the central nervous system (CNS) produce lesions (demyelinated areas in ... "Demyelinating diseases of the central nervous system". Medicine. 11 (77): 4601-4609. doi:10.1016/j.med.2015.04.001. Poser C. M ...
... a Almirante Clemente class destroyer the ICD-10 code for a benign neoplasm of brain and other parts of central nervous system ...
... the ICD-10 code for a neoplasm of uncertain or unknown behaviour of brain and central nervous system Semi-Slav Defense chess ...
Benign neoplasm of meninges (D33) Benign neoplasm of brain and other parts of central nervous system (D34) Benign neoplasm of ... Overlapping lesion of brain and other parts of central nervous system (C72.9) Central nervous system, unspecified (C73) ... Neoplasm of uncertain or unknown behaviour of brain and central nervous system (D44) Neoplasm of uncertain or unknown behaviour ... Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system (C72.0) Spinal cord (C72.1) Cauda ...
Infrequently, other soft tissues and organ systems such as central nervous system, lung etc can be involved. A few cases of ... Kaur V (2016). "A rare case of blastic plasmacytoid dendritic cell neoplasm with deletion 7q.31, in the setting of heavy pre- ... They process antigen material and present it on the surface to other cells of the immune system. Dendritic cells develop from ... 2016). "A rare case of blastic plasmacytoid dendritic cell neoplasm with deletion 7q.31, in the setting of heavy pre-treatment ...
Primary central nervous system lymphoma (200.6) Anaplastic large cell lymphoma (200.7) Large cell lymphoma (200.8) Other named ... Benign neoplasm of eye (225) Benign neoplasm of brain and other parts of nervous system (226) Benign neoplasm of thyroid glands ... Malignant neoplasm of brain (192) Malignant neoplasm of other and unspecified parts of nervous system (192.0) Cranial nerve ( ... Neoplasm of uncertain behavior of endocrine glands and nervous system (237.0) Pituitary gland and craniopharyngeal duct ...
Weeks and associates reported on 111 renal rhabdoid cases of which 13.5% also had a central nervous system malignancy. It has ... MRTs are a rare and highly malignant childhood neoplasm. Later rhabdoid tumours outside the kidney were reported in many ... PJ Biggs; Garen PD; Powers JM; Garvin AJ (1987). "Malignant rhabdoid tumor of the central nervous system". Hum Pathol. 18 (4): ... and the central nervous system. Several cases of primary intracranial MRT have been reported since its recognition as a ...
3.4 Other neoplasms related to the meninges 3.4.1 Haemangioblastoma (ICD-O 9161/1, WHO grade I) 4.1 Malignant Lymphomas (ICD-O ... Grading of the tumors of the central nervous system See the article Grading of the tumors of the central nervous system. Louis ... WHO pathology of tumours of central nervous system-2007 Zülch, Histological typing of tumours of the central nervous system. ... version of the last 2007 WHO classification of the tumours of the central nervous system. Currently, as of 2016, clinicians are ...
... cranial nerves and other parts of central nervous system ICD-10 code Siemens C72, a mobile phone Honda C71, C76, C72, C77 Dream ... C72 may refer to : Ruy Lopez chess openings ECO code Malignant neoplasm of spinal cord, ...
Central pain syndrome (338.1) Acute pain (338.2) Chronic pain (338.3) Neoplasm related pain (acute) (chronic) (338.4) Chronic ... Other demyelinating diseases of central nervous system (341.0) Neuromyelitis optica (341.1) Schilder's disease (341.2) Acute ... Other and unspecified disorders of the nervous system (349.0) Headache, post spinal puncture Post dural puncture headache ( ... 349.8) Other specified disorders of nervous system (349.81) Cerebrospinal fluid rhinorrhea (349.82) Toxic encephalopathy (350) ...
Of numerous grading systems in use for the classification of tumor of the central nervous system, the World Health Organization ... Neoplasms will often show as differently colored masses (also referred to as processes) in CT or MRI results. ... WHO classification of the tumors of the central nervous system. Anaplastic astrocytoma, Astrocytoma, Central neurocytoma, ... The central nervous system cancer survival rate in children is approximately 60%. The rate varies with the type of cancer and ...
WHO classification of the tumors of the central nervous system. Anaplastic astrocytoma, Astrocytoma, Central neurocytoma, ... The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ... Grading of the tumors of the central nervous system commonly occurs on a 4 point scale (I-IV) created by the World Health ... Blood vessels enter the central nervous system through the perivascular space above the pia mater. The cells in the blood ...
Nervous tissue tumors/NS neoplasm/Neuroectodermal tumor (ICD-O 9350-9589) (C70-C72, D32-D33, 191-192/225) ... Central. nervous system. Encephalitis/. meningitis. DNA virus. JCV Progressive multifocal leukoencephalopathy. RNA virus. MeV ... A primary central nervous system lymphoma (PCNSL), also known as microglioma and primary brain lymphoma,[1] is a primary ... Fine HA, Mayer RJ (December 1993). "Primary central nervous system lymphoma". Ann. Intern. Med. 119 (11): 1093-104. doi:10.7326 ...
Infections of the central nervous system may also be associated with decreased LOC; for example, an altered LOC is the most ... Neoplasms within the intracranial cavity can also affect consciousness, as can epilepsy and post-seizure states. A decreased ... Scheld WM, Whitley RJ, Marra CM (2004). Infections of the Central Nervous System. Hagerstown, MD: Lippincott Williams & Wilkins ... Since this system is thought to modulate wakefulness and sleep, interference with it, such as injury, illness, or metabolic ...
... hypothalamic neoplasms MeSH C10.551.240.250.700.500.500 --- pituitary neoplasms MeSH C10.551.240.375 --- central nervous system ... central nervous system MeSH C10.228.140.300.850.125 --- aids arteritis, central nervous system MeSH C10.228.140.300.850.250 ... central nervous system MeSH C10.500.190.600 --- central nervous system venous angioma MeSH C10.500.190.800 --- sinus pericranii ... central nervous system MeSH C10.114.875.350 --- lupus vasculitis, central nervous system MeSH C10.114.875.700 --- temporal ...
History of stroke, dementia, or central nervous system damage within 1 year Head trauma within 3 weeks or brain surgery within ... known intracranial arteriovenous malformation or previously known intracranial neoplasm Suspected recent (within 30 days) ... 6 months Known intracranial neoplasm Suspected aortic dissection Internal bleeding within 6 weeks Active bleeding or known ...
Radiation on the Central Nervous System and Pituitary Gland of Macaque Monkeys A Study of 67 Brains and Spinal Cords and 77 ... Kent, S. P., & Pickering, J. E. (1958). Neoplasms in monkeys (Macaca mulatta): spontaneous and irradiation induced. Cancer, 11( ... Radiation on the Central Nervous System and Pituitary Gland of Macaque Monkeys A Study of 67 Brains and Spinal Cords and 77 ... The family were lifelong Methodists and members of the Central United Methodist Church of Albuquerque since 1989 when they ...
He studied functional restoration in the central nervous system and performed North America's first human stereotactic cerebral ... he developed early refinements of microsurgical techniques for the management of intracranial neoplasms. Specifically, he ... The biological restoration of central nervous system architecture and function: part 1-foundations and historical landmarks in ... "Combined Modality Therapy of Central Nervous System Tumors". ISBN 9783540006275. Hoh DJ, Liu CY, Pagnini PG, Yu C, Wang MY, ...
... headache evaluation may include CT scan or MRI in order to look for possible structural disorders of the central nervous system ... intracranial neoplasm, epileptic seizure or other types of disorders or diseases that are intracranial but that are not ... According to this system, there are 19 types of neuralgias and headaches due to different central causes of facial pain. ... associated with the vasculature of the central nervous system. ICHD-2 classifies headaches that are caused by the ingestion of ...
Of numerous grading systems in use for the classification of tumor of the central nervous system, the World Health Organization ... Neoplasms will often show as differently colored masses (also referred to as processes) in CT or MRI results. Benign brain ... The central nervous system cancer survival rate in children is approximately 60%. The rate varies with the type of cancer and ... Blood vessels enter the central nervous system through the perivascular space above the pia mater. The cells in the blood ...
Nodal marginal zone B cell lymphoma Non-Hodgkin lymphoma Precursor B lymphoblastic leukemia Primary central nervous system ... Marginal zone B-cell lymphoma Mast cell leukemia Mediastinal large B cell lymphoma Multiple myeloma/plasma cell neoplasm ...
... neoplasms of the central nervous system, emotional and behavior disorders, and intellectual disability.[23] ... and the central nervous system.[24] Peripheral nervous system effects are more prominent in adults and central nervous system ... By organ systemEdit. Lead affects every one of the body's organ systems, especially the nervous system, but also the bones and ... impairment of central nervous system function.[53]. Lead exposure in children is also correlated with neuropsychiatric ...
Echevarría ME, Fangusaro J, Goldman S (June 2008). "Pediatric central nervous system germ cell tumors: a review". Oncologist 13 ... Gurney, James G; Smith, Malcolm A; Bunin, Greta R. "CNS and Miscellaneous Intracranial and Instraspinal Neoplasms" (PDF). SEER ... approximately 2,200 children and adolescents younger than 20 years of age are diagnosed with malignant central nervous system ...
... during pregnancy and elevated risk of childhood malignant central nervous system (CNS) tumours has been found. Human DNA ... Use of topoisomerase inhibitors for antineoplastic treatments may lead to secondary neoplasms because of DNA damaging ... coffee and tea consumption during pregnancy and childhood malignant central nervous system tumours: the ESCALE study (SFCE)". ... in aqueous system over a wide temperature range". Journal of Agricultural and Food Chemistry. 56 (8): 2694-701. doi:10.1021/ ...
... s arise from neoplastic astrocytes, a type of glial cell found in the central nervous system. They may ... because the borders of the neoplasm tend to send out tiny microscopic fibrillary tentacles that spread into the surrounding ...
... was originally classified as the most primitive neoplasm of the Central Nervous System (CNS) by Bailey and ... Central nervous system medulloepithelioma a series of eight cases including two arising in the pons. J Neurosurg 1996;84:430-6 ... Pathology of tumors the nervous system, 5th ed. Baltimore: Williams & Wilkins 1989; pp. 247-51. Sato T, Shimoda A, Takahishi T ...
The World Health Organization, a specialized agency that classifies abnormal tumors affecting the central nervous system and ... often mistaking astroblastoma with glial neoplasms, high-grade astrocytes, and embryonal neoplasms. However, the "bubbly" ... Calcification deriving from nervous system tumors is a rare quality in astroblastoma patients, but it is nonetheless easy to ... "Astroblastoma in a Child." Children Nervous System 24.2 (2008): 165-68. Sughrue, Michael E., Jay Choi, Martin Rutkowski, and ...
Central nervous system involvement, as described above, most often takes the form of meningeal leukemia, or invasion of the ... Vega F, Medeiros LJ, Bueso-Ramos CE, Arboleda P, Miranda RN (2015). "Hematolymphoid neoplasms associated with rearrangements of ... True chloromas (i.e. solid leukemic tumors) of the central nervous system are exceedingly rare, but has been described. ... although very rarely occurring solid central nervous system tumors composed of leukemic cells can be termed chloromas. In ...
central nervous system development. • metanephric comma-shaped body morphogenesis. • branching involved in ureteric bud ... aka Hurthle-Cell Neoplasms).[15] Tumors expressing the PAX8/PPARy are usually present in at a young age, small in size, present ... urogenital system development. • sulfur compound metabolic process. • metanephric S-shaped body morphogenesis. • metanephros ... Also functions in very early stages of kidney organogenesis, the müllerian system, and the thymus.[7] Additionally, PAX8 is ...
... including the nervous system. In the central nervous system, the three outer membranes (the meninges) that envelop the brain ... Connective tissue neoplasms including sarcomas such as hemangiopericytoma and malignant peripheral nerve sheath tumor in ... Mixed connective tissue disease - a disease of the autoimmune system, also undifferentiated connective tissue disease. ... and nervous tissue. It develops from the mesoderm. Connective tissue is found in between other tissues everywhere in the body, ...
Malignant neoplasms of the brain and nervous system (1.5%). *Retinal detachment (1.4%) ... Central visual acuity of 20/200 or less in the better eye with corrective glasses or central visual acuity of more than 20/200 ... a b c Morello, C. M. "Etiology and Natural History of Diabetic Retinopathy: An Overview." American Journal of Health-System ... Defined as having central visual acuity of less than 3/60 with normal fields of vision, or gross visual field restriction. ...
Central. nervous system. Encephalitis/. meningitis. DNA virus. JCV Progressive multifocal leukoencephalopathy. RNA virus. MeV ... 2005). "Assessment of JC polyoma virus in colon neoplasms". Dis. Colon. Rectum. 48 (1): 86-91. doi:10.1007/s10350-004-0737-2. ... JCV can cross the blood-brain barrier into the central nervous system, where it infects oligodendrocytes and astrocytes, ... JCV found in the central nervous system of PML patients almost invariably have differences in promoter sequence to the JCV ...
... central nervous system - cerebrum - cerebrospinal fluid (CSF) - cervical cancer - cervical dysplasia - cervical intraepithelial ... neoplasm - nephrotoxic - neuralgia - neurological complications of AIDS - neuropathy - neutralization - neutralizing antibody ... immune system - immune thrombocytopenic purpura - immunity - immunization - immunocompetent - immunocompromised - ...
Diseases of the nervous system VII H00-H59 Diseases of the eye and adnexa ... Neoplasms III D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism ... It is actually the official mental health system for the US as well, but even many professionals do not realize this due to the ...
... and preganglionic autonomic nerve fibers lead to them directly from the central nervous system. The adrenal medulla affects ... Neoplasms include: *Pheochromocytoma (most common), a catecholamine-secreting tumor of the adrenal medulla[1][5] ... As a cluster of neuron cell bodies, the adrenal medulla is considered a modified ganglion of the sympathetic nervous system.[2] ... These cells are intimately connected with the sympathetic division of the autonomic nervous system (ANS). These adrenal ...
... particularly the central nervous system, it is called a germinoma.[3] ... It is a malignant neoplasm and is one of the most treatable and curable cancers, with a survival rate above 95% if discovered ... Tumors of the male urogenital system (C60-C63/D29, 185-187/222) ...
... late effect neuropathy may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS). In the CNS ... Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ... "A Novel Method for Tumor Localization and Tracking in Radiation Therapy". IEEE Asilomar Conference on Signals, Systems and ... Wing-Fai Loke; Tae-Young Choi; Teimour Maleki; Lech Papiez; Babak Ziaie; Byunghoo Jung (2010). "Magnetic Tracking System for ...
Echevarría ME, Fangusaro J, Goldman S (2008). "Pediatric central nervous system germ cell tumors: a review". Oncologist. 13 (6 ... "CNS and Miscellaneous Intracranial and Instraspinal Neoplasms" (PDF). SEER Pediatric Monograph. National Cancer Institute. pp ... approximately 2,200 children and adolescents younger than 20 years of age are diagnosed with malignant central nervous system ...
A81.9) Atypical virus infection of central nervous system, unspecified *Prion disease of central nervous system NOS ... B21.) Human Immunodeficiency Virus (HIV) disease Resulting in malignant neoplasms *(B21.0) HIV disease resulting in Kaposi's ... A89.) Unspecified viral infection of central nervous system. (A90-A99) Arthropod-borne viral fevers and viral haemorrhagic ... A80-A89) Viral infections of the central nervous system[संपादित करें]. *(A80.) Acute poliomyelitis ...
Bleyer WA (August 1988). "Central nervous system leukemia". Pediatric Clinics of North America. 35 (4): 789-814. doi:10.1016/ ... "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): ... Central nervous system (CNS) symptoms such as cranial neuropathies due to meningeal infiltration are identified in less than 10 ... Due to presence of CNS involvement in 10-40% of adult with ALL at diagnosis, most providers start Central nervous system (CNS) ...
顱神經和脊柱神經(英语:WHO classification of the tumors of the central nervous system#2. Tumours of cranial and paraspinal nerves): 神經纖維瘤 ... 腦垂腺(英语:Pituitary neoplasm). *垂體腺瘤(英语:Pituitary adenoma):泌乳素瘤(英语:Prolactinoma) ... 神經上皮(英语:WHO classification of the tumors of the central nervous system#1. Tumours of neuroepithelial tissue). (脑肿瘤、. 脊柱腫瘤(英语: ... 顱腦區域的腫瘤(英语:WHO classification of the
Central nervous system disorders. *Genodermatoses. Hidden categories: *Infobox medical condition (new). *Articles to be ... Nervous tissue tumors/NS neoplasm/Neuroectodermal tumor (ICD-O 9350-9589) (C70-C72, D32-D33, 191-192/225) ... Note: Not all brain tumors are of nervous tissue, and not all nervous tissue tumors are in the brain (see brain metastasis).. ... Kumar, R; Vaid, VK; Kalra, SK (July 2007). "Lhermitte-Duclos disease". Child's Nervous System. 23 (7): 729-32. doi:10.1007/ ...
... nervous system changes (headache, weakness, dizziness, balance problems, seizures), jaundice, lumps near the surface of the ... Nodules less than 1 cm from the trachea, main bronchi, oesophagus and central vessels should be excluded from RFA given high ... Large cell lung carcinoma (LCLC) is a heterogeneous group of undifferentiated malignant neoplasms originating from transformed ... a promising prognostic system". Clin. Cancer Res. 11 (12): 4400-5. doi:10.1158/1078-0432.CCR-04-2378. PMID 15958624.. ...
If the cancer has central nervous system involvement, or with meningeal disease, intrathecal chemotherapy may be administered.[ ... Secondary neoplasm[edit]. Development of secondary neoplasia after successful chemotherapy or radiotherapy treatment can occur ... Agarwala SS, Kirkwood JM (2000). "Temozolomide, a novel alkylating agent with activity in the central nervous system, may ... Journal of the Peripheral Nervous System. 2008 Mar;13(1):27-46. doi:10.1111/j.1529-8027.2008.00156.x. PMID 18346229. ...
"Neoplasms and cancer" has been chosen to reflect the fact that not all tumours are benign. The word "cancer" has been included ... Template:Peripheral nervous system navs(edit talk links history). *Template:Protein classification navs(edit talk links history ... "https://kn.wikipedia.org/w/index.php?title=ಟೆಂಪ್ಲೇಟು:Central_nervous_system_navs&oldid=724046" ಇಂದ ಪಡೆಯಲ್ಪಟ್ಟಿದೆ ... Template:Digestive system navs(edit talk links history). *Template:DNA and protein biosynthesis navs(edit talk links history)- ...
Scheld WM, Whitley RJ, Marra CM (2004). Infections of the Central Nervous System. Hagerstown, MD: Lippincott Williams & Wilkins ... Neoplasms within the intracranial cavity can also affect consciousness,[12] as can epilepsy and post-seizure states.[9] A ... Infections of the central nervous system may also be associated with decreased LOC; for example, an altered LOC is the most ... Since this system is thought to modulate wakefulness and sleep, interference with it, such as injury, illness, or metabolic ...
Malignant tumor, malignant neoplasm. A coronal CT scan showing a malignant mesothelioma. Legend: → tumor ←, ✱ central pleural ... not only through its effect on body weight but also through negative effects on the immune system and endocrine system.[43] ... They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... Metastasis is common in the late stages of cancer and it can occur via the blood or the lymphatic system or both. The typical ...
Central Nervous System: Seizures, tremors, muscular twitching, confusion, agitation, ataxia, and hallucinations. ... trophoblastic neoplasms, and ovarian carcinoma. Moreover, it also has been used as an immunosuppressive drug for various ... "The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.. ... the most effective and safe medicines needed in a health system.[3] The wholesale cost in the developing world is about 111.87 ...
en:Central nervous system disease (5). *en:Central venous catheter (19). *en:Cerebral palsy (47) → 뇌성마비 ... en:Neoplasm (40) → 신생물 *en:Nephrotic syndrome (38) → 신증후군 *en:Nervous system disease (4) ...
... and involvement of the central nervous system or liver at the time of diagnosis.[142] ... Horn, L; Lovly, CM; Johnson, DH (2015). "Chapter 107: Neoplasms of the lung". In Kasper, DL; Hauser, SL; Jameson, JL; Fauci, AS ... may invade the local part of the sympathetic nervous system, leading to Horner's syndrome (dropping of the eyelid and a small ... BioMed Central. 2 (1): 22. doi:10.1186/1750-1172-2-22. PMC 1868710 . PMID 17480225. Archived from the original on 27 September ...
... late effect neuropathy may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS). In the CNS ... Effects on pituitary systemEdit. Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms ... "A Novel Method for Tumor Localization and Tracking in Radiation Therapy". IEEE Asilomar Conference on Signals, Systems and ... Wing-Fai Loke; Tae-Young Choi; Teimour Maleki; Lech Papiez; Babak Ziaie; Byunghoo Jung (2010). "Magnetic Tracking System for ...
Activity of the cells in the islets is also affected by the autonomic nervous system. ... Acute pancreatitis is likely to cause intense pain in the central abdomen, that often radiates to the back, and may be ... "Solid pseudopapillary neoplasm of the pancreas: a single institution experience of 14 cases". HPB. 8 (2): 148-50. doi:10.1080/ ... The pancreas[note 1] is an organ of the digestive system and endocrine system of vertebrates. In humans, it is located in the ...
... late effect neuropathy may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS). In the CNS ... Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ... "A Novel Method for Tumor Localization and Tracking in Radiation Therapy". IEEE Asilomar Conference on Signals, Systems and ... Maleki T, Papiez L, Ziaie B (August 2010). "Magnetic tracking system for radiation therapy". IEEE Transactions on Biomedical ...
CAD systems have been found to be highly sensitive in the detection of melanoma, but have a high false-positive rate. There is ... Tumors: Skin neoplasm, skin appendages / Adnexal and skin appendage (C44.L40-L68/D23.L15-49, 173/216) ... cytoplasm and central nucleus).[32] ... Tumors: Skin neoplasm, nevi and melanomas (C43/D22, 172/216, ...
Alexs Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United ... Central Nervous System Neoplasms / epidemiology* * Glioma / epidemiology* * Humans * Neoplasms, Germ Cell and Embryonal / ... Alexs Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United ... The CBTRUS Statistical Report: Alexs Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System ...
New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the Childhood Cancer ... Central Nervous System Lymphomas. Central nervous system (CNS) lymphomas can affect both people with healthy immune systems and ... People with impaired immune systems have an increased risk of developing central nervous system lymphomas. Organ ... Symptoms occur if the tumor directly damages the nerves in the brain or central nervous system, or if its growth puts pressure ...
Stem Cell Biology in Neoplasms of the Central Nervous System. Editors. * Moneeb Ehtesham ... Stem Cell Biology in Neoplasms of the Central Nervous System. Editors: Ehtesham, Moneeb (Ed.) ... This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors ... Emerging Strategies for the Treatment of Tumor Stem Cells in Central Nervous System Malignancies ...
Hoffman on central nervous system neoplasms drugs: Many drugs act on the brain, some because they are meant to, others as side ... Central nervous system neoplasms signs * Medicine for central nervous system neoplasms * Central nervous system neoplasms ... Brain & spinal cord: The central nervous system is made up of the brain and spinal cord. The peripheral nervous system is made ... that involves the central nervous system. Central nervous is composed of the brain and spinal cord. Myelin sheaths protect and ...
Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children`s Research Hospital ... Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children`s Research Hospital ... Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Childrens Research Hospital ... BACKGROUND: Details on second neoplasms (SNs) following pediatric central nervous system (CNS) tumors are scant, because of the ...
... report of a case presenting with lung and central nervous system involvement and review of the literature.(Case study) by The ... general Central nervous system diseases Case studies Diagnosis Dendritic cells Diseases Lung diseases ... MLA style: "Blastic plasmacytoid dendritic cell neoplasm: report of a case presenting with lung and central nervous system ... APA style: Blastic plasmacytoid dendritic cell neoplasm: report of a case presenting with lung and central nervous system ...
Characterization of the Blood Brain Barrier in Pediatric Central Nervous System Neoplasms ...
MalaCards based summary : Central Nervous System Organ Benign Neoplasm is related to central nervous system germinoma and ... MalaCards integrated aliases for Central Nervous System Organ Benign Neoplasm:. Name: Central Nervous System Organ Benign ... Pathways related to Central Nervous System Organ Benign Neoplasm according to GeneCards Suite gene sharing:. #. Super pathways ... MGI Mouse Phenotypes related to Central Nervous System Organ Benign Neoplasm:. 46 #. Description. MGI Source Accession. Score. ...
Regulatory peptides in neuronal neoplasms of the central nervous system. F. Giangaspero, P. C. Burger, D. A. Budwit, L. ... Regulatory peptides in neuronal neoplasms of the central nervous system. / Giangaspero, F.; Burger, P. C.; Budwit, D. A.; ... title = "Regulatory peptides in neuronal neoplasms of the central nervous system",. abstract = "Neuronal tumors of CNS were ... Regulatory peptides in neuronal neoplasms of the central nervous system. Clinical Neuropathology. 1985;4(3):111-115. ...
Comparison of methods for response analysis of central nervous system neoplasms. S. S. Miranpuri, C. A. Schulz, R. J. Chappell ... Fingerprint Dive into the research topics of Comparison of methods for response analysis of central nervous system neoplasms ...
Adult primary central nervous system vasculitis. Abstract Mulvihill, John J. International Epidemiology Institute. 07/23/2010. ... Autoimmune T cell responses in the central nervous system. Abstract Ferretti, Patrizia. c/o Max-Planck Institute for Molecular ... Targeting protein kinases in central nervous system disorders. Abstract Branson, Helen M. University of Toronto. 11/06/2011. ... CXCL13 and CXCL12 in central nervous system lymphoma patients. Abstract Winer, Eric P. Dana-Farber Cancer Institute. 02/20/2009 ...
Central Nervous System Neoplasms -- secondary Label Central Nervous System Neoplasms -- secondary. Focus * Central Nervous ... Central Nervous System Neoplasms -- secondary Resource Information The concept Central Nervous System Neoplasms -- secondary ... Data Citation of the Concept Central Nervous System Neoplasms -- secondary. Copy and paste the following RDF/HTML data fragment ... Context of Central Nervous System Neoplasms -- secondary Subject of. No resources found ...
... Dr. Satish Pathak, Dr. Sakshi Daga ... Sakshi Daga, "Pleomorphic Xanthoastrocytoma - A Rare Neoplasm of Central Nervous System", International Journal of Science and ... Pleomorphic Xanthoastrocytoma - A Rare Neoplasm of Central Nervous System. Dr. Satish Pathak, Dr. Sakshi Daga ...
The role of stem cells in pediatric central nervous system malignancies. - Laboratory models for central nervous system tumor ... Post a Comment for Stem Cell Biology in Neoplasms of the Central Nervous System ... Add tags for Stem Cell Biology in Neoplasms of the Central Nervous System ... This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors ...
Method: Retrospective study of all consecutive cases of CNS neoplasms diagnosed at The Aga Khan University Hospital (AKUH) ... of patients the histological pattern of CNS neoplasms and to provide a comprehensive data about the frequency of CNS neoplasms ... Glial tumours were the commonest primary CNS neoplasms followed by meningiomas . Among glial tumours , astrocytomas comprised ... Histological pattern of central nervous system neoplasms. Journal of Pakistan Medical Association, 51(4), 154-157.. Available ...
Do you qualify for these Primary Malignant Central Nervous System Neoplasm studies? Were researching the most effective ... Primary Malignant Central Nervous System Neoplasm clinical trials at UC Health 2 research studies open to eligible people ...
This study assesses the BRAF V600E mutation status in 969 intracranial neoplasms using a tissue microarray method and ... Thirty-six out of 969 (4 %) analyzed central nervous system neoplasms were immunohistochemically positive for the BRAF V600E ... Cases with primary central nervous system (CNS) tumors and metastases in advanced stages, where established therapies are ... The role of BRAF mutations in primary central nervous system tumors has been addressed by several studies that mostly showed ...
Medical Marijuana in the Pediatric Central Nervous System Tumor Population. *Central Nervous System Tumor ... neoplasms [CONDITION] AND child [AGE-GROUP] , Recruiting, Not yet recruiting, Available Studies (1984 records) ... neoplasms [CONDITION] AND child [AGE-GROUP] , Recruiting, Not yet recruiting, Available Studies ... 1984 Studies found for: neoplasms [CONDITION] AND child [AGE-GROUP] , Recruiting, Not yet recruiting, Available Studies ...
Do you qualify for these Primary Malignant Central Nervous System Neoplasm studies? Were researching the most effective ... Primary Malignant Central Nervous System Neoplasm clinical trials at UCSF 2 research studies open to eligible people ...
Central Nervous System Neoplasms / drug therapy. Central Nervous System Neoplasms / radiotherapy. Lymphoma / drug therapy. ... MeSH-major] Central Nervous System Neoplasms / drug therapy. Central Nervous System Neoplasms / radiotherapy. Germinoma / drug ... Primary central nervous system lymphoma (PCNSL) is a non-Hodgkins lymphoma arising in the central nervous system. ... Central Nervous System Neoplasms / drug therapy. Drug Administration Schedule. Drug Resistance, Neoplasm / drug effects. Glioma ...
Central Nervous System Neoplasms. Nervous System Neoplasms. Neoplasms by Site. Spinal Cord Diseases. Central Nervous System ... Neoplasm Metastasis. Spinal Cord Neoplasms. Neoplastic Processes. Neoplasms. Pathologic Processes. ... Adult Spinal Cord Neoplasm Spinal Bone Metastases Spinal Cord Metastases Procedure: therapeutic conventional surgery ...
Central Nervous System Neoplasms. Nervous System Neoplasms. Brain Diseases. Central Nervous System Diseases. Nervous System ... Breast Neoplasms. Neoplasm Metastasis. Neoplasms, Second Primary. Brain Neoplasms. Neoplasms by Site. Neoplasms. Breast ...
Brain Neoplasms. Neoplasms. Central Nervous System Neoplasms. Nervous System Neoplasms. Neoplasms by Site. Central Nervous ...
Neoplasms , Solid Tumors Harboring NTRK Fusion , Cancer/Tumors , Cancer (Pediatric) , Solid Tumors Habouring NTRK Fusion , A ... Clinical trial for Central Nervous System Neoplasms , Cancer , Ewings Family Tumors , ... Conditions: Central Nervous System Neoplasms , Cancer , Ewings Family Tumors , Neoplasms , Solid Tumors Harboring NTRK Fusion ...
Mortality from central nervous system neoplasms. Together they form a unique fingerprint. * Central Nervous System Neoplasms ... Long-term health experience of jet engine manufacturing workers: I. Mortality from central nervous system neoplasms. Journal of ... Long-term health experience of jet engine manufacturing workers : I. Mortality from central nervous system neoplasms. / Marsh, ... title = "Long-term health experience of jet engine manufacturing workers: I. Mortality from central nervous system neoplasms", ...
Details on second neoplasms (SNs) following pediatric central nervous system (CNS) tumors are scant, because of the rarity of ... Details on second neoplasms (SNs) following pediatric central nervous system (CNS) tumors are scant, because of the rarity of ... Details on second neoplasms (SNs) following pediatric central nervous system (CNS) tumors are scant, because of the rarity of ... Details on second neoplasms (SNs) following pediatric central nervous system (CNS) tumors are scant, because of the rarity of ...
DRG Group #054-055 - Nervous system neoplasms with MCC. * DRG Group #054-055 - Nervous system neoplasms without MCC. ... Neoplasm of uncertain behavior of other specified parts of central nervous system The ICD-10-CM Neoplasms Index links the ... Neoplasm of uncertain behavior of other specified parts of central nervous system BILLABLE Billable Code Billable codes are ... Parent Code: D43 - Neoplasm of uncertain behavior of brain and central nervous system ...
Central Nervous System Neoplasm. Cervical Cancer. Cholangiocarcinoma. Chronic Lymphocytic Leukemia (CLL). Chronic Myelogenous ... Due to the different physician groups and hospitals within the Wake Forest Baptist system, physician services and hospital ...
Central Nervous System Neoplasm. Cholangiocarcinoma. Chondrosarcoma. Colorectal Cancer. Dermatofibrosarcoma Protuberans. ... Due to the different physician groups and hospitals within the Wake Forest Baptist system, physician services and hospital ...
CENTRAL NERVOUS SYSTEM INFECTIONS; BRAIN NEOPLASMS; CRANIOCEREBRAL TRAUMA; and other conditions. Impaired resorption of ... Choroid Plexus Neoplasms. Benign or malignant tumors which arise from the choroid plexus of the ventricles of the brain. ...
1989). Neoplasms of the central nervous system. In: Devita S., Hellman, S., Rosenberg, S. A., editors. Cancer: Principles and ... Schoenberg, B. S. (1983). Epidemiology of central nervous system tumor. In: Walker, M D, editor. Oncology of the Nervous System ... System Xc is a Na+-independent glutamate transport system that has been functionally described for several decades (2). System ... One candidate system for this glutamate-cystine exchange is system Xc. A combination of RT-PCR and Western blots was used to ...
  • These findings suggest that neural stem cells are enriched in PCNSL as a reaction rather than as a source of the tumors and that sox2 expression is indicative of a neural progenitor/stem cell response to non-neural neoplasms. (umsystem.edu)
  • Further understanding of the reactive response of neural stem cells is needed for understanding of neural neoplasm pathology. (umsystem.edu)
  • Although almost all of PCNSLs show contrast enhancement, lesions with central necrosis are much more likely in immunocompromised patients, whereas those in immunocompetent hosts are solidly contrast enhancing ( 15 , 16 ). (neupsykey.com)
  • Molecular signatures are being increasingly incorporated into cancer classification systems. (biomedcentral.com)
  • DNA methylation-based central nervous system (CNS) tumor classification is being recognized as having the potential to aid in cases of difficult histopathological diagnoses. (biomedcentral.com)
  • The classification and diagnosis of central nervous system (CNS) tumors, as with all neoplastic processes, is essential in determining optimal patient treatment decisions. (biomedcentral.com)
  • 1 Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH USA Central Brain Tumor Registry of the United States, Hinsdale, IL USA. (nih.gov)
  • The presence of these findings in diverse central nervous system neoplasms and manipulation of the observation for therapeutic benefit have yet to be explored. (umsystem.edu)
  • The present disclosure teaches that glioma cells are dependent on system Xc for cystine uptake. (freepatentsonline.com)
  • 3. The method of claim 2 where said glioma depends on said system Xc for at least about 85% of cystine uptake. (freepatentsonline.com)
  • Chordoid glioma has been recently described as a slow-growing neoplasm with chordoid appearance, occurring exclusively in the regions of the third ventricle and hypothalamus of middle-aged women. (semanticscholar.org)
  • The authors of this study aimed to genetically design a bispecific targeted toxin that would simultaneously target overexpressed markers on glioma as well as the tumor vasculature, to mutate certain amino acids to reduce the immunogenicity of this new drug, and to determine whether the drug was able to effectively reduce aggressive human brain tumors in a rat xenograft model via a novel hollow fiber (HF) catheter delivery system. (thejns.org)
  • Glioma (GLM): Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. (nih.gov)
  • Subjects were newly diagnosed adults residing in the San Francisco Bay Surveillance Epidemiology and End Results Area during 1991 to 1994 and 1997 to 1999 with central neuropathology review ( n = 873). (aacrjournals.org)
  • The malignant brain neoplasm excesses in certain subgroups of workers from NH may reflect external occupational factors, nonoccupational factors or workplace factors unique to NH that were not measured in the current study. (elsevier.com)
  • Sixteen non-neuronal intracranial neoplasms were examined as controls. (elsevier.com)
  • This study assesses the BRAF V600E mutation status in 969 intracranial neoplasms using a tissue microarray method and immunohistochemical staining with the mutation-specific VE-1 antibody, followed by sequencing of positively stained cases. (biomedcentral.com)
  • It is a malignant neoplasm of the pancreas. (abcam.com)
  • Central nervous system (CNS) metastases, including parenchymal and leptomeningeal metastases, are the most common causes of malignant disease in the brain, and are diagnosed in 100,000 to 170,000 patients per year in the U.S. alone ( 1 , 2 ). (aacrjournals.org)
  • H3F3A and H3F3B mutations affecting residues involved in post-translational modifications of histone H3.3 are implicated in the pathogenesis of some bone and cartilage neoplasms. (nih.gov)
  • D37 Neoplasm of uncertain behavior of oral cavity. (icd10data.com)
  • Brain Tumor News: Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children`s Research Hospital experience. (virtualtrials.com)
  • 3 Central Brain Tumor Registry of the United States, Hinsdale, IL USA. (nih.gov)
  • To address these issues, numerous engineered nanoparticles (e.g. iron oxide nanoparticles, gold nanoparticles, nanoliposomes) have been used as drug delivery systems capable of penetrating the BBB and delivering therapeutic agents to the GBM tumor site 10 . (nature.com)
  • Central Brain Tumor Registry of the United States of America (CBTRUS 2008/2011) data shows that 64,530 new cases of primary NS tumors were diagnosed in 2010, which represents 1.44% of all malign neoplasms diagnosed in the USA. (frontiersin.org)
  • The humoral and innate arms of the immune system have not been well studied in brain tumor survival. (aacrjournals.org)
  • The PDQ childhood brain tumor treatment summaries are primarily organized according to the World Health Organization classification of nervous system tumors. (cancer.gov)
  • For a full description of the classification of nervous system tumors and a link to the corresponding treatment summary for each type of brain tumor, refer to the PDQ summary on Childhood Brain and Spinal Cord Tumors Treatment Overview . (cancer.gov)
  • However, in the Central Nervous System Atypical Teratoid/Rhabdoid Tumor Registry (AT/RT Registry), 12 of the 42 patients (29%) were older than 36 months at the time of diagnosis. (cancer.gov)
  • D43.8 is a billable ICD code used to specify a diagnosis of neoplasm of uncertain behavior of other specified parts of central nervous system. (icd.codes)
  • D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made. (icd10data.com)
  • D37.0 Neoplasm of uncertain behavior of lip, oral c. (icd10data.com)
  • D37.03 Neoplasm of uncertain behavior of the major s. (icd10data.com)
  • D37.030 Neoplasm of uncertain behavior of the parotid. (icd10data.com)
  • D37.031 Neoplasm of uncertain behavior of the subling. (icd10data.com)
  • D37.032 Neoplasm of uncertain behavior of the submand. (icd10data.com)
  • D37.04 Neoplasm of uncertain behavior of the minor s. (icd10data.com)
  • D37.09 Neoplasm of uncertain behavior of other speci. (icd10data.com)
  • D37.2 Neoplasm of uncertain behavior of small intes. (icd10data.com)
  • D37.6 Neoplasm of uncertain behavior of liver, gall. (icd10data.com)
  • D37.8 Neoplasm of uncertain behavior of other speci. (icd10data.com)
  • D37.9 Neoplasm of uncertain behavior of digestive o. (icd10data.com)
  • D38.1 Neoplasm of uncertain behavior of trachea, br. (icd10data.com)
  • D38.3 Neoplasm of uncertain behavior of mediastinum. (icd10data.com)
  • D49.0 Neoplasm of unspecified behavior of digestive. (icd10data.com)
  • D49.1 Neoplasm of unspecified behavior of respirato. (icd10data.com)
  • D49.2 Neoplasm of unspecified behavior of bone, sof. (icd10data.com)
  • D49.5 Neoplasm of unspecified behavior of other gen. (icd10data.com)
  • D49.511 Neoplasm of unspecified behavior of right kid. (icd10data.com)
  • D49.512 Neoplasm of unspecified behavior of left kidn. (icd10data.com)
  • D49.519 Neoplasm of unspecified behavior of unspecifi. (icd10data.com)
  • D49.59 Neoplasm of unspecified behavior of other gen. (icd10data.com)
  • D49.7 Neoplasm of unspecified behavior of endocrine. (icd10data.com)
  • D49.8 Neoplasm of unspecified behavior of other spe. (icd10data.com)
  • D49.81 Neoplasm of unspecified behavior of retina an. (icd10data.com)
  • D49.89 Neoplasm of unspecified behavior of other spe. (icd10data.com)
  • Conclusions: PCNSL is a neoplasm with a very poor prognosis and short survival even with CNS radiation therapy. (scielo.org.pe)
  • Conclusions: Total cohort mortality rates for malignant, benign or unspecified CNS neoplasms were not elevated relative to the US and CT general populations. (elsevier.com)
  • How do diseases attack the central nervous system? (healthtap.com)
  • What are different diseases of the central nervous system? (healthtap.com)
  • LEXINGTON, Mass.--(BUSINESS WIRE)--Agenus Inc. (NASDAQ: AGEN), a biotechnology company developing novel immune system activating treatments for cancers and infectious diseases, today announced results published from a Phase 2 study demonstrated that more than 90% of the patients treated with Prophage Series G-200 were alive at six months after surgery and 30% were alive at twelve months. (fiercebiotech.com)
  • Diseases associated with GSE1 include Central Nervous System Primitive Neuroectodermal Neoplasm . (genecards.org)
  • The previous method of diagnosis coding, International Classification of Diseases, 9th Edition, Clinical Modification/Procedure Coding System (ICD-9), used in the United States since 1978, contained outdated terminology and did not allow for updates in healthcare that have occurred in the 21st century. (asco.org)
  • Many countries around the world have utilized the International Classification of Diseases, 10th Edition, Clinical Modification/Procedure Coding System (ICD-10 CM/PCS) for years, including Australia, France, Canada, Germany, the United Kingdom, and South Africa. (asco.org)
  • AYA neoplasms also differ from those in middle-aged and elderly people, in whom malignancies of epithelial cell origin or carcinomas of several primary sites account for more than 85% of cancers ( 3 ). (scielo.br)
  • Neoplasms of central nervous system accounts for approximately 1% of tumors of the human body, and they can be primary or secondary (metastatic), benign or malignant, and intra-axial or extra-axial. (intechopen.com)
  • Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. (umassmed.edu)
  • Wadasadawala T, Trivedi S, Gupta T, Epari S, Jalali R (2010) The diagnostic dilemma of primary central nervous system melanoma. (springer.com)
  • AbstractIn line with the ongoing phase I trial (NCT03784625) dedicated to melanoma targeted radionuclide therapy (TRT), we explore the interplay between immune system and the melanin ligand [131I]ICF01012 alone or combined with immunotherapy (immune checkpoint inhibitors, ICI) in preclinical models. (medworm.com)
  • With the knowledge that females generally have a more robust immune system than males, we investigated sex differences in melanoma progression in a B16-F10/BL6 syngeneic mouse model. (medworm.com)
  • The concept Central Nervous System Neoplasms -- secondary represents the subject, aboutness, idea or notion of resources found in University of Missouri Libraries . (missouri.edu)
  • In 2010, more than 22,000 Americans were estimated to have been diagnosed and 13,140 were estimated to have died from brain and other nervous system cancers. (nih.gov)
  • The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. (springer.com)
  • Brain Neoplasms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (harvard.edu)
  • A curable complete resection should be achieved if possible while preserving the nervous function of the spinal cord and minimizing potential complications. (intechopen.com)
  • Expert-reviewed information summary about the treatment of adult central nervous system tumors. (oncolink.org)
  • Work-related asthma in Massachusetts: population-based data from the 2006 & 2007 Behavioral Risk Factor Surveillance System adult asthma call-back survey. (cdc.gov)
  • This could be due to life style changes since the reunification in eastern Germany influencing early immune system training. (nih.gov)
  • In the latent phase, the cysts provoke the immune system (e.g. lymphocytes, plasma cells and macrophages), stimulating mild inflammation [ 13 ]. (royalsocietypublishing.org)
  • That some brain tumors can depress the immune system has been known for some time ( 16 , 17 ). (aacrjournals.org)