AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Nervous System NeoplasmsCentral Nervous System NeoplasmsPeripheral Nervous System NeoplasmsCentral Nervous SystemDigestive System NeoplasmsCentral Nervous System DiseasesNervous SystemBrainCentral Nervous System InfectionsPeripheral Nervous SystemCentral Nervous System Viral DiseasesNeuronsVasculitis, Central Nervous SystemCentral Nervous System AgentsSpinal CordNeoplasmsPancreatic NeoplasmsCentral Nervous System Fungal InfectionsEnteric Nervous SystemImmunohistochemistryNervous System Physiological PhenomenaAutonomic Nervous SystemNervous System DiseasesNeurogliaCentral Nervous System Bacterial InfectionsSympathetic Nervous SystemBlood-Brain BarrierMyelin SheathNeoplasms, Cystic, Mucinous, and SerousAstrocytesNerve Tissue ProteinsTuberculosis, Central Nervous SystemDemyelinating DiseasesBrain DiseasesEncephalomyelitis, Autoimmune, ExperimentalAxonsOligodendrogliaIn Situ HybridizationMolecular Sequence DataCerebrospinal FluidSkin NeoplasmsMice, Inbred C57BLGene Expression Regulation, DevelopmentalNeoplasms, Multiple PrimaryMultiple SclerosisBrain NeoplasmsEncephalomyelitisMeningeal NeoplasmsSpinal Cord NeoplasmsTime FactorsMicrogliaLymphomaEncephalitisNeoplasms, Second PrimaryEncephalitis, ViralKidney NeoplasmsDisease Models, AnimalMeningoencephalitisRNA, MessengerAmino Acid SequenceCells, CulturedBrain ChemistryRats, Sprague-DawleyMagnetic Resonance ImagingTrauma, Nervous SystemMyelin ProteinsMice, KnockoutPeripheral NervesMice, TransgenicSignal TransductionInjections, IntraventricularBase SequenceTissue DistributionCerebellumMutationMeningesNerve RegenerationGlial Fibrillary Acidic ProteinEye NeoplasmsThyroid NeoplasmsCell DifferentiationAdenocarcinoma, MucinousFatal OutcomeDNA, NeoplasmLeechesMyeloproliferative DisordersLung NeoplasmsLupus Vasculitis, Central Nervous SystemMyelin Basic ProteinCerebral CortexCerebellar NeoplasmsAnimals, NewbornParotid NeoplasmsLiver NeoplasmsEmbryo, NonmammalianAstrocytomaDrosophila ProteinsCystadenomaGene ExpressionGanglia
Nervous System Neoplasms
Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.
Central Nervous System Neoplasms
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
Peripheral Nervous System Neoplasms
Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)
Central Nervous System
The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.
Digestive System Neoplasms
Tumors or cancer of the DIGESTIVE SYSTEM.
Central Nervous System Diseases
Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
Nervous System
The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Central Nervous System Infections
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
Peripheral Nervous System
The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
Central Nervous System Viral Diseases
Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.
Neurons
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Vasculitis, Central Nervous System
Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)
Central Nervous System Agents
A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252)
Spinal Cord
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Central Nervous System Fungal Infections
MYCOSES of the brain, spinal cord, and meninges which may result in ENCEPHALITIS; MENINGITIS, FUNGAL; MYELITIS; BRAIN ABSCESS; and EPIDURAL ABSCESS. Certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME).
Enteric Nervous System
Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)
Immunohistochemistry
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Nervous System Physiological Phenomena
Characteristic properties and processes of the NERVOUS SYSTEM as a whole or with reference to the peripheral or the CENTRAL NERVOUS SYSTEM.
Autonomic Nervous System
The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.
Nervous System Diseases
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
Neuroglia
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Central Nervous System Bacterial Infections
Bacterial infections of the brain, spinal cord, and meninges, including infections involving the perimeningeal spaces.
Sympathetic Nervous System
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Blood-Brain Barrier
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
Myelin Sheath
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
Neoplasms, Cystic, Mucinous, and Serous
Neoplasms containing cyst-like formations or producing mucin or serum.
Astrocytes
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Nerve Tissue Proteins
Tuberculosis, Central Nervous System
Tuberculosis of the brain, spinal cord, or meninges (TUBERCULOSIS, MENINGEAL), most often caused by MYCOBACTERIUM TUBERCULOSIS and rarely by MYCOBACTERIUM BOVIS. The infection may be limited to the nervous system or coexist in other organs (e.g., TUBERCULOSIS, PULMONARY). The organism tends to seed the meninges causing a diffuse meningitis and leads to the formation of TUBERCULOMA, which may occur within the brain, spinal cord, or perimeningeal spaces. Tuberculous involvement of the vertebral column (TUBERCULOSIS, SPINAL) may result in nerve root or spinal cord compression. (From Adams et al., Principles of Neurology, 6th ed, pp717-20)
Demyelinating Diseases
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
Brain Diseases
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
Encephalomyelitis, Autoimmune, Experimental
An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
Axons
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
Oligodendroglia
A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.
In Situ Hybridization
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Cerebrospinal Fluid
A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.
Skin Neoplasms
Tumors or cancer of the SKIN.
Mice, Inbred C57BL
Gene Expression Regulation, Developmental
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Neoplasms, Multiple Primary
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Multiple Sclerosis
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Encephalomyelitis
A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.
Meningeal Neoplasms
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
Spinal Cord Neoplasms
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Microglia
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
Lymphoma
A general term for various neoplastic diseases of the lymphoid tissue.
Encephalitis
Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.
Neoplasms, Second Primary
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Encephalitis, Viral
Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of TOGAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.
Kidney Neoplasms
Tumors or cancers of the KIDNEY.
Disease Models, Animal
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Meningoencephalitis
An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Brain Chemistry
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Rats, Sprague-Dawley
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Magnetic Resonance Imaging
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Trauma, Nervous System
Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures.
Myelin Proteins
MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Peripheral Nerves
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
Mice, Transgenic
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Injections, Intraventricular
Injections into the cerebral ventricles.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Tissue Distribution
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Cerebellum
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Meninges
The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.
Nerve Regeneration
Renewal or physiological repair of damaged nerve tissue.
Glial Fibrillary Acidic Protein
An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.
Eye Neoplasms
Tumors or cancer of the EYE.
Thyroid Neoplasms
Tumors or cancer of the THYROID GLAND.
Cell Differentiation
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Adenocarcinoma, Mucinous
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Fatal Outcome
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
DNA, Neoplasm
DNA present in neoplastic tissue.
Leeches
Annelids of the class Hirudinea. Some species, the bloodsuckers, may become temporarily parasitic upon animals, including man. Medicinal leeches (HIRUDO MEDICINALIS) have been used therapeutically for drawing blood since ancient times.
Myeloproliferative Disorders
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
Lung Neoplasms
Tumors or cancer of the LUNG.
Lupus Vasculitis, Central Nervous System
Central nervous system vasculitis that is associated with SYSTEMIC LUPUS ERYTHEMATOSUS. Clinical manifestations may include DEMENTIA; SEIZURES; CRANIAL NERVE DISEASES; HEMIPARESIS; BLINDNESS; DYSPHASIA; and other neurological disorders.
Myelin Basic Protein
An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.
Cerebral Cortex
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
Cerebellar Neoplasms
Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
Animals, Newborn
Refers to animals in the period of time just after birth.
Parotid Neoplasms
Tumors or cancer of the PAROTID GLAND.
Liver Neoplasms
Tumors or cancer of the LIVER.
Embryo, Nonmammalian
The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.
Astrocytoma
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
Drosophila Proteins
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
Cystadenoma
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)
Gene Expression
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Ganglia
Clusters of multipolar neurons surrounded by a capsule of loosely organized CONNECTIVE TISSUE located outside the CENTRAL NERVOUS SYSTEM.
Neoplasms, Connective and Soft Tissue
Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.
Brain Stem
The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
Neoplasms, Plasma Cell
Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.
Appendiceal Neoplasms
Tumors or cancer of the APPENDIX.
Drosophila
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
Neoplasms, Experimental
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Meningitis, Viral
Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)
Neuropeptides
Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.
Endocrine Gland Neoplasms
Tumors or cancer of the ENDOCRINE GLANDS.
Meningioma
A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
Stem Cells
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Central Nervous System Protozoal Infections
Infections of the brain, spinal cord, or meninges by single celled organisms of the former subkingdom known as protozoa. The central nervous system may be the primary or secondary site of protozoal infection. These diseases may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts.
Organ Specificity
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.
Dog Diseases
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Neoplasms, Radiation-Induced
Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Hippocampus
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
Phenotype
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Cystadenoma, Mucinous
A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Testicular Neoplasms
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Myelin-Associated Glycoprotein
A myelin protein found in the periaxonal membrane of both the central and peripheral nervous systems myelin sheaths. It binds to cells surface receptors found on AXONS and may regulate cellular interactions between MYELIN and AXONS.
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Myelin-Oligodendrocyte Glycoprotein
A transmembrane protein present in the MYELIN SHEATH of the CENTRAL NERVOUS SYSTEM. It is one of the main autoantigens implicated in the pathogenesis of MULTIPLE SCLEROSIS.
Transcription Factors
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Tomography, X-Ray Computed
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Hypothalamus
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
Theilovirus
A species of CARDIOVIRUS which contains three strains: Theiler's murine encephalomyelitis virus, Vilyuisk human encephalomyelitis virus, and Rat encephalomyelitis virus.
Nerve Degeneration
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
Peripheral Nervous System Diseases
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
Gastrointestinal Neoplasms
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Neurogenesis
Formation of NEURONS which involves the differentiation and division of STEM CELLS in which one or both of the daughter cells become neurons.
Gene Expression Regulation
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Carcinoma, Pancreatic Ductal
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
AIDS Dementia Complex
A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
Autonomic Nervous System Diseases
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
Demyelinating Autoimmune Diseases, CNS
Conditions characterized by loss or dysfunction of myelin (see MYELIN SHEATH) in the brain, spinal cord, or optic nerves secondary to autoimmune mediated processes. This may take the form of a humoral or cellular immune response directed toward myelin or OLIGODENDROGLIA associated autoantigens.
Meningitis
Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
Neoplasms, Vascular Tissue
Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.
Reverse Transcriptase Polymerase Chain Reaction
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Motor Neurons
Neurons which activate MUSCLE CELLS.
Neuroaspergillosis
Infections of the nervous system caused by fungi of the genus ASPERGILLUS, most commonly ASPERGILLUS FUMIGATUS. Aspergillus infections may occur in immunocompetent hosts, but are more prevalent in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES. The organism may spread to the nervous system from focal infections in the lung, mastoid region, sinuses, inner ear, bones, eyes, gastrointestinal tract, and heart. Sinus infections may be locally invasive and enter the intracranial compartment, producing MENINGITIS, FUNGAL; cranial neuropathies; and abscesses in the frontal lobes of the brain. (From Joynt, Clinical Neurology, 1998, Ch 27, pp62-3)
Brain Abscess
A circumscribed collection of purulent exudate in the brain, due to bacterial and other infections. The majority are caused by spread of infected material from a focus of suppuration elsewhere in the body, notably the PARANASAL SINUSES, middle ear (see EAR, MIDDLE); HEART (see also ENDOCARDITIS, BACTERIAL), and LUNG. Penetrating CRANIOCEREBRAL TRAUMA and NEUROSURGICAL PROCEDURES may also be associated with this condition. Clinical manifestations include HEADACHE; SEIZURES; focal neurologic deficits; and alterations of consciousness. (Adams et al., Principles of Neurology, 6th ed, pp712-6)
Neoplasm Staging
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Sciatic Nerve
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Neurodegenerative Diseases
Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.

Second-line treatment for primary central nervous system lymphoma. (1/857)

Failure after first-line treatment was reported in 35-60% of immunocompetent patients with primary central nervous system lymphoma (PCNSL). There are currently no reports focusing on salvage therapy. This review analyses prognostic factors and the efficacy of salvage therapy by focusing on data from papers reporting results of first-line treatment in 355 cases. The study group consisted of 173 patients presenting treatment failure. The interval between failure and death (TTD) was compared for age at relapse (< or =60 vs. >60 years), type of failure (relapse vs. progression), time to relapse (< or =12 vs. >12 months) and salvage treatment (yes vs no). Median TTD was similar in younger and older patients (P = 0.09). Relapsed patients had a longer TTD than patients with progressive disease (P = 0.002). Early relapse led to a shorter TTD than late relapse (P = 0.005). Median TTD was 14 months for patients who underwent salvage therapy and 2 months for untreated cases (P<0.00001). A multivariate analysis showed an independent prognostic role for salvage therapy and time to relapse. Age and type of failure had no predictive value. Salvage therapy significantly improves outcome and, possibly, quality of life. As many different treatments were used conclusions cannot be made regarding an optimal treatment schedule.  (+info)

Neurologic complications of systemic cancer. (2/857)

Neurologic complications occur frequently in patients with cancer. After routine chemotherapy, these complications are the most common reason for hospitalization of these patients. Brain metastases are the most prevalent complication, affecting 20 to 40 percent of cancer patients and typically presenting as headache, altered mental status or focal weakness. Other common metastatic complications are epidural spinal cord compression and leptomeningeal metastases. Cord compression can be a medical emergency, and the rapid institution of high-dose corticosteroid therapy, radiation therapy or surgical decompression is often necessary to preserve neurologic function. Leptomeningeal metastases should be suspected when a patient presents with neurologic dysfunction in more than one site. Metabolic encephalopathy is the common nonmetastatic cause of altered mental status in cancer patients. Cerebrovascular complications such as stroke or hemorrhage can occur in a variety of tumor-related conditions, including direct invasion, coagulation disorders, chemotherapy side effects and nonbacterial thrombotic endocarditis. Radiation therapy is the most commonly employed palliative measure for metastases. Chemotherapy or surgical removal of tumors is used in selected patients.  (+info)

Phase II trial of primary chemotherapy followed by reduced-dose radiation for CNS germ cell tumors. (3/857)

PURPOSE: A prospective phase II study was initiated to assess the response rate, survival, and late effects of treatment in patients with newly diagnosed CNS germ cell tumors (GCT), using etoposide plus cisplatin followed by radiation therapy prescribed by extent of disease, histology, and response to chemotherapy. PATIENTS AND METHODS: Seventeen patients aged 8 to 24 years with histologically proven CNS GCT received etoposide (100 mg/m2/d) plus cisplatin (20 mg/m2/d) daily for 5 days every 3 weeks for four cycles, followed by radiation therapy. Nine patients had germinomas; eight had mixed GCT. Four patients (three with germinomas and one with mixed GCT) presented with leptomeningeal dissemination. RESULTS: Radiographically, 14 of 17 patients were assessable for response; 11 patients experienced complete regression, and three had major partial regression before radiation. Six of seven assessable patients with elevated CSF levels of alpha-fetoprotein or betahuman chorionic gonadotropin had normalization with chemotherapy alone; all normalized with combined chemotherapy and radiation therapy. All 17 patients are alive without evidence of disease (median follow-up, 51 months). One patient developed a relapse in the spinal leptomeninges and was rendered free of disease with spinal radiation more than 5 years ago. One patient developed carotid stenosis requiring surgery. Thus far, only minimal long-term deterioration in neurocognitive function has been detected as a consequence of protocol treatment. CONCLUSION: Conventional-dose intravenous chemotherapy with etoposide and cisplatin can effect tumor regression in a high proportion of patients with CNS GCT, including those with leptomeningeal metastases. Acute and long-term toxicities are acceptable. Progression-free survival and overall survival are excellent.  (+info)

Third International Meeting on von Hippel-Lindau disease. (4/857)

Five years after the identification of the von Hippel-Lindau (VHL) gene, physicians, scientists and concerned VHL family members met to review the current state of knowledge on the diagnosis and treatment of VHL and to summarize the latest information on the biochemistry of the VHL protein (pVHL). The NIH and University of Pennsylvania groups reported the detection of germ-line mutations in 100% (93 of 93) of VHL families studied. Several studies determined the frequency of VHL germ-line mutations in individuals with a single manifestation of VHL without a family history of VHL. National groups to improve the diagnosis and treatment of individuals with VHL disease have been established in Great Britain, Denmark, France, Holland, Italy, Japan, Poland, and the United States. Evidence for the existence of genes that modify the expression of VHL was presented. The VHL protein appears to have several distinct functions: (a) down-regulation of hypoxia-inducible mRNAs; (b) proper assembly of the extracellular fibronectin matrix; (c) regulation of exit from the cell cycle; and (d) regulation of expression of carbonic anhydrases 9 and 12.  (+info)

Cancer surveillance series [corrected]: brain and other central nervous system cancers: recent trends in incidence and mortality. (5/857)

BACKGROUND: During the 1980s, the incidence of primary malignant brain and other central nervous system tumors (hereafter called brain cancer) was reported to be increasing among all age groups in the United States, while mortality was declining for persons younger than 65 years. We analyzed these data to provide updates on incidence and mortality trends for brain cancer in the United States and to examine these patterns in search of their causes. METHODS: Data on incidence, overall and according to histology and anatomic site, and on relative survival were obtained from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute for 1975 through 1995. Mortality data were obtained from the National Center for Health Statistics. Medicare procedure claims from the National Cancer Institute's SEER-Medicare database were used for imaging trends. Statistically significant changes in incidence trends were identified, and annual percent changes were computed for log linear models. RESULTS/CONCLUSIONS: Rates stabilized for all age groups during the most recent period for which SEER data were available, except for the group containing individuals 85 years of age or older. Mortality trends continued to decline for the younger age groups, and the steep increases in mortality seen in the past for the elderly slowed substantially. Patterns differed by age group according to the site and grade of tumors between younger and older patients. During the last decade, use of computed tomography scans was relatively stable for those 65-74 years old but increased among those 85 years old or older. IMPLICATIONS: Improvements in diagnosis and changes in the diagnosis and treatment of elderly patients provide likely explanations for the observed patterns in brain cancer trends.  (+info)

V(H) gene sequences from primary central nervous system lymphomas indicate derivation from highly mutated germinal center B cells with ongoing mutational activity. (6/857)

Primary central nervous system lymphoma (PCNSL) represents 1% to 3% intracranial tumors. Most PCNSL are located in the brain, and 75% are large B-cell lymphomas. The largest subgroup of these tumors contains cells that resemble centroblasts and has been labelled diffuse centroblastic (polymorphous) lymphoma. To investigate the cell of origin and the clonal history of these tumors, we have analyzed V(H) gene of 5 cases of PCNSL, all confirmed by histological studies to be Epstein-Barr virus (EBV)-negative, high-grade diffuse B-cell lymphomas. The V4-34 gene of the V(H)4 family was used in 4 of 5 cases. All V(H) genes were found to have accumulated very high levels of somatic mutation (14% to 25%). In 3 of 5 cases, intraclonal nucleotide heterogeneity, including codon deletion in some clones in 1 case, was observed, indicating that the V(H) genes were still under the influence of the somatic hypermutation mechanism. Analysis of the distribution of silent and replacement mutations showed evidence for preservation of immunoglobulin structure in all cases. These results suggest that, although there is no evidence for germinal center formation in the brain tissue, PCNSL is derived from a B cell with features associated with location in a germinal center environment.  (+info)

Association of childhood cancer with factors related to pregnancy and birth. (7/857)

BACKGROUND: It has been hypothesized that risk factors of childhood cancers may already operate during the prenatal and neonatal period. Results of previous epidemiological studies have been inconsistent. METHODS: During 1992-1997 a large case-control study on childhood cancers and a variety of potential risk factors was conducted in Germany. Cases were ascertained by the German Childhood Cancer Registry. Each case was matched to a population-based control of the same age and gender, sampled from the district where the case lived at the date of diagnosis. For the analyses, 2358 cases and 2588 controls were available. RESULTS: Risk of childhood acute leukaemia increased with maternal age < or =20 years at time of delivery (odds ratio [OR] = 1.9, 95% CI: 1.1-3.2), lower (<2500 g: OR = 1.7, 95% CI: 1.1-2.8) and higher birthweight (>4000 g: OR = 1.4, 95% CI: 1.0-1.8, P < 0.05), and hormonal treatment because of infertility (OR = 1.6, 95% CI: 1.0-2.5, P < 0.05). No associations were seen for parental smoking habits, maternal alcohol consumption during pregnancy and fetal losses. Parity was associated only with subgroups of acute leukaemias. Regarding non-Hodgkin's lymphoma we observed an elevated OR for lower birthweight and heavy maternal smoking during pregnancy (>20 cigarettes/day) and a decreased OR for children with one or two siblings. Only a few significant findings were seen for the different groups of solid tumours. CONCLUSIONS: Overall, only weak associations were identified and the evaluated risk factors operating during the neonatal and prenatal period account at most for only a small proportion of childhood cancers.  (+info)

Paucity of leukemic progenitor cells in the bone marrow of pediatric B-lineage acute lymphoblastic leukemia patients with an isolated extramedullary first relapse. (8/857)

Isolated extramedullary relapse in childhood acute lymphoblastic leukemia (ALL) may be accompanied by occult bone marrow disease. We used a highly sensitive assay to quantify leukemic progenitor cells (LPCs) in the bone marrow of such patients. Multiparameter flow cytometry and blast colony assays were used to detect LPCs in the bone marrow of 31 pediatric B-lineage ALL patients with an isolated extramedullary first relapse. Sites of relapse were central nervous system (22 patients), testes (7 patients), and eye (2 patients). Bone marrow (BM) LPC counts ranged from 0/10(6) mononuclear cells (MNCs) to 356/10(6) MNCs (mean +/- SE, 27.8+/-13.1/10(6) MNCs). LPCs were undetectable in 19 patients (61%). The BM LPC burden at the time of extramedullary relapse was similar, regardless of site (Wilcoxon P = 0.77) or time of relapse (Wilcoxon P = 0.80). Compared with higher risk, standard risk at initial diagnosis showed a trend for increased BM LPC burden (mean +/- SE, 44.6+/-17.1 versus 7.5+/-3.3; Wilcoxon P = 0.22). After successful postrelapse induction chemotherapy, LPC counts in 21 evaluated patients ranged from 0/10(6) to 175/10(6) MNCs (mean +/- SE, 15.9+/-9.6/10(6) MNCs). By comparison, LPC burden was higher after successful induction chemotherapy among children with an early BM relapse (range, 0 to 3262/ 106 MNC; mean +/- SE, 166+/-107; Wilcoxon P = 0.11). Thus, not all patients with an extramedullary relapse have occult systemic failure with substantial involvement of the bone marrow, and after reinduction therapy, LPC counts were lower in these patients than in patients treated for an overt BM first relapse.  (+info)

LMO2 and BCL6 are associated with improved survival in primary central nervous system lymphoma<...
TY - JOUR. T1 - LMO2 and BCL6 are associated with improved survival in primary central nervous system lymphoma. AU - Lossos, Chen. AU - Bayraktar, Soley. AU - Weinzierl, Elizabeth. AU - Younes, Sheren F.. AU - Hosein, Peter. AU - Tibshirani, Robert J.. AU - Sutton Posthumus, Jocelyn. AU - Deangelis, Lisa M.. AU - Raizer, Jeffrey. AU - Schiff, David. AU - Abrey, Lauren. AU - Natkunam, Yasodha. AU - Lossos, Izidore. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Primary central nervous system lymphoma (PCNSL) is an aggressive sub-variant of non-Hodgkin lymphoma (NHL) with morphological similarities to diffuse large B-cell lymphoma (DLBCL). While methotrexate (MTX)-based therapies have improved patient survival, the disease remains incurable in most cases and its pathogenesis is poorly understood. We evaluated 69 cases of PCNSL for the expression of HGAL (also known as GCSAM), LMO2 and BCL6 - genes associated with DLBCL prognosis and pathobiology, and analysed their correlation to survival in 49 PCNSL patients ...
https://miami.pure.elsevier.com/en/publications/lmo2-and-bcl6-are-associated-with-improved-survival-in-primary-ce
The molecular and phenotypic profile of primary central nervous system lymphoma identifies distinct categories of the disease...
TY - JOUR. T1 - The molecular and phenotypic profile of primary central nervous system lymphoma identifies distinct categories of the disease and is consistent with histogenetic derivation from germinal center-related B cells. AU - Larocca, Luigi Maria. AU - Capello, Daniela. AU - Rinelli, Alessandro. AU - Nori, Simonetta. AU - Antinori, Andrea. AU - Gloghini, Annunziata. AU - Cingolani, Antonella. AU - Migliazza, Anna. AU - Saglio, Giuseppe. AU - Cammilleri-Broet, Sophie. AU - Raphael, Martine. AU - Carbone, Antonino. AU - Gaidano, Gianluca. PY - 1998/8/1. Y1 - 1998/8/1. N2 - Primary central nervous system lymphoma (PCNSL) is a major cause of morbidity and mortality among human immunodeficiency virus (HIV)-infected individuals. The precise histogenetic derivation and the molecular pathogenesis of PCNSL is poorly understood. In an attempt to clarify the histogenesis and pathogenesis of these lymphomas, 49 PCNSL (26 acquired immunodeficiency syndrome [AIDS]-related and 23 AIDS-unrelated) were ...
https://moh-it.pure.elsevier.com/en/publications/the-molecular-and-phenotypic-profile-of-primary-central-nervous-s
Primary central nervous system lymphoma: Phase I evaluation of infusional bromodeoxyuridine with whole brain accelerated...Primary central nervous system lymphoma: Phase I evaluation of infusional bromodeoxyuridine with whole brain accelerated...
TY - JOUR. T1 - Primary central nervous system lymphoma. T2 - Phase I evaluation of infusional bromodeoxyuridine with whole brain accelerated fractionation radiation therapy after chemotherapy. AU - Dabaja, Bouthaina S.. AU - McLaughlin, Peter. AU - Ha, Chul S.. AU - Pro, Barbara. AU - Meyers, Christina A.. AU - Seabrooke, Lee F.. AU - Wilder, Richard B.. AU - Kyritsis, Athanassios P.. AU - Preti, H. Alejandro. AU - Yung, W. K.Alfred. AU - Levin, Victor. AU - Cabanillas, Fernando. AU - Cox, James D.. PY - 2003/9/1. Y1 - 2003/9/1. N2 - BACKGROUND. The current study was performed to determine the maximum tolerated dose (MTD), toxicity, and outcome of infusional 5 bromo-2′-deoxyuridine (bromodeoxyuridine; BUdR) given with accelerated fractionation whole brain radiation therapy (WBRT) after chemotherapy for the treatment of primary central nervous system lymphoma (PCNSL). METHODS. Twelve patients with untreated and histologically confirmed PCNSL were entered on the study between 1994 and 1996. ...
https://scholars.uthscsa.edu/en/publications/primary-central-nervous-system-lymphoma-phase-i-evaluation-of-inf
Impact of maintenance rituximab on duration of response in primary central nervous system lymphoma<...Impact of maintenance rituximab on duration of response in primary central nervous system lymphoma<...
TY - JOUR. T1 - Impact of maintenance rituximab on duration of response in primary central nervous system lymphoma. AU - Ambady, Prakash. AU - Fu, Rongwei. AU - Szidonya, Laszlo. AU - Peereboom, David M.. AU - Doolittle, Nancy D.. AU - Neuwelt, Edward A.. N1 - Funding Information: This work was supported in part by National Institute of Health Grants CA137488, NS044687, a Veterans Administration Merit Review Grant and the Walter S. and Lucienne Driskill Foundation, all to EAN. Funding Information: This work was supported in part by National Institute of Health Grants CA137488, NS044687, a Veterans Administration Merit Review Grant and the Walter S. and Lucienne Driskill Foundation, all to EAN. Publisher Copyright: © 2020, Springer Science+Business Media, LLC, part of Springer Nature.. PY - 2020/3/1. Y1 - 2020/3/1. N2 - Purpose: The role of maintenance immunotherapy with anti-CD20 monoclonal antibody rituximab in primary central nervous system lymphoma (PCNSL) is unclear. We retrospectively ...
https://ohsu.pure.elsevier.com/en/publications/impact-of-maintenance-rituximab-on-duration-of-response-in-primar
Primary central nervous system lymphoma - Canadian Cancer SocietyPrimary central nervous system lymphoma - Canadian Cancer Society
Primary central nervous system lymphoma (PCNSL) starts in the brain, spinal cord, meninges or eyes. Learn about primary central nervous system lymphoma.
https://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/more-types-of-nhl/primary-cns-lymphoma/?region=sk
Zidovudine Plus Interleukin-2 and Ganciclovir in Treating Patients With AIDS-Related Primary Central Nervous System Lymphoma -...Zidovudine Plus Interleukin-2 and Ganciclovir in Treating Patients With AIDS-Related Primary Central Nervous System Lymphoma -...
RATIONALE: Antiviral drugs such as zidovudine and ganciclovir act against viruses and may be an effective treatment for HIV. Interleukin-2 may stimulate a persons white blood cells to kill lymphoma cells. Combining these treatments may be effective in treating AIDS-related primary central nervous system lymphoma.. PURPOSE: Phase II trial to study the effectiveness of combining zidovudine, ganciclovir, and interleukin-2 in treating patients who have AIDS-related primary central nervous system lymphoma. ...
https://clinicaltrials.gov/show/NCT00006264?order=488
International study on low-grade primary central nervous system lymphoma<...
TY - JOUR. T1 - International study on low-grade primary central nervous system lymphoma. AU - Jahnke, Kristoph. AU - Korfei, Agnieszka. AU - ONeill, Brian Patrick. AU - Blay, Jean Yves. AU - Abrey, Lauren E.. AU - Martus, Peter. AU - Poortmans, Philip M.P.. AU - Shenkier, Tamara N.. AU - Batchelor, Tracy T.. AU - Neuwelt, Edward A.. AU - Raizer, Jeffrey J.. AU - Schiff, David. AU - Pels, Hendrik. AU - Herrlinger, Ulrich. AU - Stein, Harald. AU - Thiel, Eckhard. PY - 2006/5. Y1 - 2006/5. N2 - Objective: The aim of this study was to characterize the clinical presentation, course, and outcome of low-grade primary central nervous system lymphoma. Methods: Cases were assessed in a retrospective series collected from 18 cancer centers in 5 countries. Results: Forty patients (18 men, 22 women; median age, 60 years [range, 19-78]) were identified. Involvement of a cerebral hemisphere or deeper brain structures was seen in 37 patients, only leptomeningeal involvement in 2 patients, and spinal cord ...
https://mayoclinic.pure.elsevier.com/en/publications/international-study-on-low-grade-primary-central-nervous-system-l
Case report: Disorder of excessive somnolence due to central nervous system lymphoma<...
TY - JOUR. T1 - Case report. T2 - Disorder of excessive somnolence due to central nervous system lymphoma. AU - Lesser, R. P.. AU - St Louis, P.. AU - Dinner, D. S.. AU - Hanson, M.. AU - Little, J. R.. AU - Slugg, P. H.. PY - 1983/1/1. Y1 - 1983/1/1. N2 - We report a patient who developed confusion and recurrent daytime episodes of hypersomnolence. His symptoms proved to be due to a diencephalic primary central nervous system lymphoma, implying that a diencephalic defect in some instances may be involved in the pathogenesis of recurrent sleep attacks.. AB - We report a patient who developed confusion and recurrent daytime episodes of hypersomnolence. His symptoms proved to be due to a diencephalic primary central nervous system lymphoma, implying that a diencephalic defect in some instances may be involved in the pathogenesis of recurrent sleep attacks.. UR - http://www.scopus.com/inward/record.url?scp=0020655405&partnerID=8YFLogxK. UR - ...
https://jhu.pure.elsevier.com/en/publications/case-report-disorder-of-excessive-somnolence-due-to-central-nervo-3
Prediction of radiosensitivity in primary central nervous system germ cell tumors using dynamic contrast-enhanced magnetic...Prediction of radiosensitivity in primary central nervous system germ cell tumors using dynamic contrast-enhanced magnetic...
Prediction of radiosensitivity in primary central nervous system germ cell tumors using dynamic contrast-enhanced magnetic resonance imaging
http://cjcr.amegroups.com/article/view/6476/7555
Prediction of radiosensitivity in primary central nervous system germ cell tumors using dynamic contrast-enhanced magnetic...Prediction of radiosensitivity in primary central nervous system germ cell tumors using dynamic contrast-enhanced magnetic...
Prediction of radiosensitivity in primary central nervous system germ cell tumors using dynamic contrast-enhanced magnetic resonance imaging
http://cjcr.amegroups.com/article/view/6476
Interstitial pneumonitis during rituximab-containing chemotherapy for primary central nervous system lymphomas: a case report...Interstitial pneumonitis during rituximab-containing chemotherapy for primary central nervous system lymphomas: a case report...
Primary central nervous system lymphoma(PCNSL) is a rare kind of non-Hodgkin lymphoma. Rituximab combined with high-dose methotrexate, cytarabine and dexamethasone (R-MAD regimen) were reported effective for PCNSL patients. Rituximab can cause several side effects, including fever, chills and rigors. In this case report, we demonstrate rituximab-induced interstitial pneumonitis in a PCNSL patient who has been treated with R-MAD regimen. The patient recovered after treatment and she remains complete remission after following consolidation chemotherapy. Here is no report of potential fatal complications of Rituximab like interstitial pneumonitis nowadays in PCNSL patients. As Rituximab is widely used, physicians should raise their awareness of this rare complication and detect RTX-ILD in early stage.
https://cnjournal.biomedcentral.com/articles/10.1186/s41016-017-0106-3
Case-based review: Primary central nervous system lymphoma<...
TY - JOUR. T1 - Case-based review. T2 - Primary central nervous system lymphoma. AU - Korfel, Agnieszka. AU - Schlegel, Uwe. AU - Johnson, Derek R.. AU - Kaufmann, Timothy J. AU - Giannini, Caterina. AU - Hirose, Takanori. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Primary CNS lymphoma (PCNSL) is a rare diffuse large B-cell lymphoma originating within the central nervous system. The overall incidence of PCNSL is rising, particularly in the elderly population. Immunosuppression is a strong risk factor, but most patients with this tumor are apparently immunocompetent. Diagnosis of PCNSL can be challenging. Non-invasive or minimally invasive tests such as ophthalmological evaluation and spinal fluid analysis may be useful, but the majority of patients require tumor biopsy for definitive diagnosis. Our knowledge concerning optimum treatment of PCNSL is fragmentary due to paucity of adequately sized trials. Most patients are now initially treated with high-dose-methotrexate-based chemotherapy alone, as the ...
https://mayoclinic.pure.elsevier.com/en/publications/case-based-review-primary-central-nervous-system-lymphoma
Clinical significance of polyglutamylation in primary central nervous system lymphoma | Acta Neuropathologica Communications |...Clinical significance of polyglutamylation in primary central nervous system lymphoma | Acta Neuropathologica Communications |...
The therapeutic response to high-dose methotrexate (HD-MTX) therapy for primary central nervous system lymphoma (PCNSL) varies. Polyglutamylation is a reversible protein modification with a high occurrence rate in tumor cells. MTX incorporated into cells is polyglutamylated and strongly binds to dihydrofolate reductase without competitive inhibition by leucovorin (LV). Tumor cells with high polyglutamylation levels are selectively killed, whereas normal cells with lower polyglutamylation are rescued by LV. We hypothesized that the extent of polyglutamylation in tumor cells determines treatment resistance. Here, we investigated the therapeutic response of PCNSL to HD-MTX therapy with LV rescue based on polyglutamylation status. Among 113 consecutive PCNSL patients who underwent HD-MTX therapy in our department between 2001 and 2014, polyglutamylation was evaluated by immunostaining in 82 cases, with relationships between polyglutamylation and therapeutic response retrospectively examined. Human malignant
https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0522-4/email/correspondent/c1/new
Evaluation of Brain Lesions in HIV-infected Patients for Diagnosis of Primary Central Nervous System Lymphoma - Full Text View ...Evaluation of Brain Lesions in HIV-infected Patients for Diagnosis of Primary Central Nervous System Lymphoma - Full Text View ...
This study will evaluate the usefulness of two tests in quickly distinguishing whether a patient with HIV infection and focal brain lesions (an injury in a specific area of the brain) has a rare type of cancer called primary central nervous system lymphoma (PCNSL), or a parasitic infection called toxoplasmic encephalitis.. Toxoplasmic encephalitis is caused by a parasite and can be treated with antibiotics. PCNSL (lymphoma of the brain or spinal cord) must be definitively diagnosed with a brain biopsy (removal of a small piece of brain tissue), and the treatment is radiation therapy and chemotherapy.. The tests under study for diagnosing PCNSL or toxoplasmic encephalitis are measurement of Epstein Barr virus (EBV) DNA in cerebrospinal fluid (CSF) and FDG-PET scan of the brain. EBV is often found in the CSF of people with PCNSL. The study also will compare the accuracy of two imaging techniques-TI-SPECT and FDG-PET-in distinguishing between toxoplasmosis and PCNSL.. Patients 18 years of age and ...
https://clinicaltrials.gov/show/NCT00226304?order=29
Neural Stem Cells in Primary Central Nervous System LymphomaNeural Stem Cells in Primary Central Nervous System Lymphoma
The initial intent of this study was to examine the origins of Primary Central Nervous System Lymphoma (PCNSL), a neoplasm whose oncogenesisin immunocompetentpatients is incompletely understood. With growing information regarding the remarkable plasticity of neural stem cells, and establishment of relationships between hematopoietic and neural stem cells, we hypothesized that PCNSL arises from neural stem/progenitor cells rather than lymphocyte precursors from elsewhere in the body. Markers of neural stem cells were chosen for immunohistochemical(IHC) staining of 5 PCNSL cases and all cases contained Sox2 positive cells, whereas 8 of 9 non-CNS B cell lymphomas so stained had no positive cells. Double-staining with Sox2 and CD20, a B-cell marker, showed no co-localization of Sox2 and CD20, and no CD20-positive tumor cells had Sox2 immunopositivity. Staining of 5 metastatic carcinomas and 1 metastatic melanoma revealed a similar pattern of immunopositivityboth regarding sox2 expression and ...
https://mospace.umsystem.edu/xmlui/handle/10355/16305
Population pharmacokinetics of high-dose methotrexate in patients with primary central nervous system lymphomaPopulation pharmacokinetics of high-dose methotrexate in patients with primary central nervous system lymphoma
Population pharmacokinetics of high-dose methotrexate in patients with primary central nervous system lymphoma | A Smarter Pharmacy
https://www.pharmdondemand.com/population-pharmacokinetics-of-high-dose-methotrexate-in-patients-with-primary-central-nervous-system-lymphoma/
B cells from HIV-infected patients with primary central nervous system lymphoma display an activated phenotype and have a...B cells from HIV-infected patients with primary central nervous system lymphoma display an activated phenotype and have a...
Each cell in HIV-associated primary central nervous system lymphoma (PCNSL) harbors latent EBV. Notably, the triggering of TLR9, a key event in HIV pathogenesis, also promotes EBV latency and transformation. We hypothesized that because only a minority of HIV-infected patients develops PCNSL, their B cells exhibit aberrant signaling responses to TLR9 triggering. We found higher levels of IL-6, CD80, and CD86 expression at baseline in B cells of those patients than in B cells of matched controls, whereas TNF-a expression was lower. Notably, on TLR9 triggering with CpG 2006, CD80 and TNF- were up-regulated to a lesser extent in B cells of the former than in those of matched controls. The reduced up-regulation of CD80 might be explained by its higher baseline expression resulting in a more blunted response rather than a specific deficit of the signaling response to TLR9 triggering. However, this cannot explain the blunted TNF- response, which warrants further investigation. Finally, since increased ...
https://edoc.unibas.ch/26647/
Primary central nervous system lymphoma and meningioma in DOTATATE PET/CT | Meta
Although meningiomas are among the most frequent intracranial tumors, primary central nervous system lymphoma represents a rare variant of extranodal non-Hodgkin-type lymphoma. Here, we report on a 73-year-old man with 2 suspicious intracerebral lesions. Combined DOTATATE PET/CT identif...read more ...
https://www.meta.org/papers/primary-central-nervous-system-lymphoma-and/24152642
Chemotherapy for Primary Central Nervous System LymphomaChemotherapy for Primary Central Nervous System Lymphoma
In this article, the authors discuss the principles guiding the use of chemotherapy for primary central nervous system lymphomas.
https://www.medscape.com/viewarticle/554260_3
Diagnosis of primary central nervous system lymphoma: A systematic review of the utility of CSF screening and the role of early...
Fingerprint Dive into the research topics of Diagnosis of primary central nervous system lymphoma: A systematic review of the utility of CSF screening and the role of early brain biopsy. Together they form a unique fingerprint. ...
https://miami.pure.elsevier.com/en/publications/diagnosis-of-primary-central-nervous-system-lymphoma-a-systematic/fingerprints/
Diagnosing Primary Central Nervous System Lymphoma | NYU Langone HealthDiagnosing Primary Central Nervous System Lymphoma | NYU Langone Health
Doctors at NYU Langone use blood testing, a neurological exam, and imaging tests to diagnose primary central nervous system lymphoma. Learn more.
https://nyulangone.org/conditions/primary-central-nervous-system-lymphoma-in-adults/diagnosis
Primary central nervous system lymphoma | Rare Diseases | RareGuruPrimary central nervous system lymphoma | Rare Diseases | RareGuru
Information on Primary central nervous system lymphoma, which may include symptoms, causes, inheritance, treatments, orphan drugs, associated orgs, and other relevant data.
https://rareguru.com/library/disease/4733/primary-central-nervous-system-lymphoma
Case-control study of paternal occupation and social class with risk of childhood central nervous system tumours in Great...
BACKGROUND: Paternal occupational exposures have been proposed as a risk factor for childhood central nervous system (CNS) tumours. This study investigates possible associations between paternal occupational exposure and childhood CNS tumours in Great Britain. METHODS: The National Registry of Childhood Tumours provided all cases of childhood CNS tumours born and diagnosed in Great Britain from 1962 to 2006. Controls without cancer were matched on sex, period of birth and birth registration sub-district. Fathers occupations were assigned to one or more of 33 exposure groups. A measure of social class was also derived from fathers occupation at the time of the childs birth. RESULTS: Of 11 119 cases of CNS tumours, 5 722 (51%) were astrocytomas or other gliomas, 2 286 (21%) were embryonal and 985 (9%) were ependymomas. There was an increased risk for CNS tumours overall with exposure to animals, odds ratio (OR) 1.40 (95% confidence intervals (CIs) 1.01, 1.94) and, after adjustment for occupational
https://www.ndph.ox.ac.uk/publications/401217
Central Nervous System Lymphoma (Primary) - OHC - Oncology Hematology CareCentral Nervous System Lymphoma (Primary) - OHC - Oncology Hematology Care
Central nervous system lymphoma is a rare non-Hodgkin lymphoma in which malignant (cancer) cells from lymph tissue form in the brain and/or spinal cord (primary CNS) or spread from other parts of the body to the brain and/or spinal cord (secondary CNS). Because the eye is so close to the brain, primary CNS lymphoma can also start in the eye (called ocular lymphoma). The cancer can also involve the spinal fluid that bathes the spinal cord and brain. This is called leptomeningeal lymphoma. See Primary Central Nervous System Lymphoma for signs, symptoms and treatments.. ...
https://www.ohcare.com/condition/central-nervous-system-lymphoma-primary/
Patterns of central nervous system recurrence in patients with systemic human immunodeficiency virus-associated non-Hodgkin...Patterns of central nervous system recurrence in patients with systemic human immunodeficiency virus-associated non-Hodgkin...
TY - JOUR. T1 - Patterns of central nervous system recurrence in patients with systemic human immunodeficiency virus-associated non-Hodgkin lymphoma. AU - Desai, Jigna. AU - Mitnick, Robin J.. AU - Henry, David H.. AU - Llena, Josefina. AU - Sparano, Joseph A.. N1 - Copyright: Copyright 2007 Elsevier B.V., All rights reserved.. PY - 1999/11/1. Y1 - 1999/11/1. N2 - BACKGROUND. Central nervous system involvement is a common manifestation of non-Hodgkin lymphoma (NHL) in human immunodeficiency virus (HIV)-infected individuals. The purpose of this study was to review the frequency and pattern of neurologic manifestation of lymphoma in a cohort of HIV-infected individuals with systemic NHL. METHODS. Sixty-two patients with HIV- associated systemic NHL received infusional cyclophosphamide, doxorubicin, and etoposide. Five patients with lymphomatous meningitis at presentation received whole brain radiation therapy plus intrathecal chemotherapy (ITC). Of the remaining 57 patients, prophylactic ITC was ...
https://einstein.pure.elsevier.com/en/publications/patterns-of-central-nervous-system-recurrence-in-patients-with-sy-2
COMBINED MODALITY TREATMENT INCLUDING METHOTREXATE-BASED CHEMOTHERAPY FOR PRIMARY CEREBRAL NERVOUS SYSTEM LYMPHOMA: A SINGLE...COMBINED MODALITY TREATMENT INCLUDING METHOTREXATE-BASED CHEMOTHERAPY FOR PRIMARY CEREBRAL NERVOUS SYSTEM LYMPHOMA: A SINGLE...
COMBINED MODALITY TREATMENT INCLUDING METHOTREXATE-BASED CHEMOTHERAPY FOR PRIMARY CEREBRAL NERVOUS SYSTEM LYMPHOMA: A SINGLE INSTITUTION EXPERIENCE
http://mjhid.org/index.php/mjhid/article/view/2009.020/64
CIENCIASMEDICASNEWS: Childhood Central Nervous System Germ Cell Tumors Treatment (PDQ®)-Health Professional Version - National...CIENCIASMEDICASNEWS: Childhood Central Nervous System Germ Cell Tumors Treatment (PDQ®)-Health Professional Version - National...
ver historia personal en: www.cerasale.com.ar [dado de baja por la Cancillería Argentina por temas políticos, propio de la censura que rige en nuestro medio]// www.revistamedicos.com.ar // www.quorumtuc.com.ar // www.sectorsalud.com.ar // www.maimonides.edu // weblog.maimonides.edu/farmacia/archives/UM_Informe_Autoevaluacion_FyB.pdf - // weblog.maimonides.edu/farmacia/archives/0216_Admin_FarmEcon.pdf - // www.documentalistas.org.ar // www.cpcesfe2.org.ar // www.nogracias.eu // www.estenssorome.com.ar // www.cuautitlan.unam.mx/descargas/licenciaturas/bqd/plandestudio_bqd_ // www.latamjpharm.org/trabajos/25/2/LAJOP_25_2_6_1_M4M6Z9746D.pdf // www.nogracias.eu/v_juventud/informacion/informacionver.asp?cod= // www.colfarse.com.ar // www.proz.com/kudoz/english_to_spanish/art_literary/523942-key_factors.html - 65k - // www.llave.connmed.com.ar/portalnoticias_vernoticia.php?codigonoticia=17715 // www.frusculleda.com.ar/homepage/espanol/activities_teaching.htm // ...
https://elbiruniblogspotcom.blogspot.com/2018/01/childhood-central-nervous-system-germ.html
Top Central Nervous System Lymphoma Hospitals in Delhi NCR | CredihealthTop Central Nervous System Lymphoma Hospitals in Delhi NCR | Credihealth
View details of top central nervous system lymphoma hospitals in Delhi NCR. Get guidance from medical experts to select best central nervous system lymphoma hospital in Delhi NCR
https://www.credihealth.com/hospitals/delhi-ncr/central-nervous-system-lymphoma
Differential gene expression of central nervous system lymphoma | Blood JournalDifferential gene expression of central nervous system lymphoma | Blood Journal
Response:. Our group published a microarray study of primary central nervous system lymphoma (PCNSL) in Blood in March 2008.1 We reported a comprehensive CNS signature of PCNSL, identifying single-gene differential expression as well as a pathway signature. Most notably, our pathway signature for PCNSL is characterized by differential expression of extracellular matrix (ECM)- and adhesion-related pathways. The most up-regulated gene is the ECM- and adhesion-related osteopontin (SPP1). Our study is unique in that we compared PCNSL to a broad spectrum of non-CNS diffuse large B-cell lymphoma (DLBCL), consisting of nodal and extranodal samples; and in-depth bioinformatics analysis was performed. This is in contrast to 2 other microarray studies in PCNSL2,3 in which the comparisons were made to nodal DLBCL and no pathway analysis was performed.. We are pleased that Rubenstein et al have confirmed our single-gene expression findings by retrospective analysis of their data and come up with concordant ...
http://www.bloodjournal.org/content/113/1/267?sso-checked=true
An immunohistological study of immunoglobulin content of primary central nervous system lymphomas | Meta
Paraffin sections of surgical and autopsy material from 24 cases of primary CNS lymphoma were examined for the presence of cytoplasmic immunoglobulin by an immunoperoxidase technique. Definite staining for cytoplasmic immunoglobulin was observed in 13 cases, and in eight of these the pattern of staining was consistent with current concepts of monoclonality. In every case the histological diagnosis of malignant lymphoma was confirmed, and cases were subclassified by both the Lukes-Collins and the Rappaport classifications. Morphologically 12 of the 24 cases resembled immunoblastic sarcoma occurring outside the CNS. Other cases showed features of follicular center cell lymphoma or plasmacytoid lymphocytic lymphoma. Of those cases with positive immunoglobulin staining of tumor cells, the majority showed some plasmacytoid features. It was concluded that the primary CNS lymphomas resemble their counterparts occurring outside the CNS, and that at least a proportion are derived from the B lymphocyte. ...
https://www.meta.org/papers/an-immunohistological-study-of-immunoglobulin/418869
Primary central nervous system lymphoma: Leukaemia FoundationPrimary central nervous system lymphoma: Leukaemia Foundation
Treatment for primary CNS lymphoma includes chemotherapy and often radiation therapy. Steroid therapy (e.g. dexamethasone) is often given before chemotherapy, as this helps reduce the swelling around the tumour, and may even shrink the tumour, reducing the raised intracranial pressure. Chemotherapy is given into a vein, and often also into the fluid surrounding the brain (intrathecally). Methotrexate is the drug most commonly given this way, and is also given in high doses intravenously- either on its own or in combination with other chemotherapy drugs and/or steroids. Radiotherapy uses high-energy rays to destroy the cancerous cells and can be an effective treatment for primary CNS lymphoma in younger people. It is used in combination with chemotherapy and steroid treatment. Surgery is only used to provide diagnostic tissue, and is never curative alone. Anticonvulsants may be given if seizures occur as a result of a tumour. If treatment is insufficient or if the disease recurs, some people are ...
http://www.leukaemia.org.au/blood-cancers/lymphomas/non-hodgkin-lymphoma-nhl/primary-central-nervous-system-lymphoma/primary-central-nervous-system-lymphoma
Phase 2 Trial of Pembrolizumab in Relapsed and Refractory Gray-Zone Lymphoma (GZL), Primary Central Nervous System Lymphoma...Phase 2 Trial of Pembrolizumab in Relapsed and Refractory Gray-Zone Lymphoma (GZL), Primary Central Nervous System Lymphoma...
This study is to find the effectiveness of pembrolizumab in patients with relapsed and refractory gray-zone lymphoma (GZL), primary central nervous system
http://adisinsight.springer.com/trials/700287961?error=cookies_not_supported&code=cf59ee2b-29c5-44ee-afda-a997c512a8cf
Childhood Central Nervous System Embryonal Tumors Treatment (PDQ®) (Patients) - Siteman Cancer CenterChildhood Central Nervous System Embryonal Tumors Treatment (PDQ®) (Patients) - Siteman Cancer Center
Learn more about Childhood Central Nervous System Embryonal Tumors Treatment (PDQ®) (Patients) from the National Cancer Institute at Siteman Cancer Center.
https://siteman.wustl.edu/ncipdq/cdr0000552550/
Role of chemotherapy additional to high-dose methotrexate for primary central nervous system lymphoma (PCNSL) - Bergner - 2011 ...Role of chemotherapy additional to high-dose methotrexate for primary central nervous system lymphoma (PCNSL) - Bergner - 2011 ...
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:. The main objective of this Cochrane review is to evaluate the role of additional chemotherapy to HD-MTX in the treatment of immunocompetent PCNSL patients with respect to overall survival (OS), progression-free survival (PFS), response rate, adverse events (AE), treatment-related mortality (TRM) and quality of life (QoL). ...
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009355/full
A phase 1 and pharmacokinetic study of enzastaurin in pediatric patients with refractory primary central nervous system tumors:...
TY - JOUR. T1 - A phase 1 and pharmacokinetic study of enzastaurin in pediatric patients with refractory primary central nervous system tumors. T2 - A pediatric brain tumor consortium study. AU - Kilburn, Lindsay B.. AU - Kocak, Mehmet. AU - Decker, Rodney L.. AU - Wetmore, Cynthia. AU - Chintagumpala, Murali. AU - Su, Jack. AU - Goldman, Stewart. AU - Banerjee, Anuradha. AU - Gilbertson, Richard. AU - Fouladi, Maryam. AU - Kun, Larry. AU - Boyett, James M.. AU - Blaney, Susan M.. N1 - Publisher Copyright: © 2014 The Author(s).. PY - 2015/2/1. Y1 - 2015/2/1. N2 - Background We sought to estimate the maximum tolerated or recommended phase 2 dose and describe the pharmacokinetics and toxicities of enzastaurin, an oral inhibitor of protein kinase Cβ 2, in children with recurrent central nervous system malignancies. Methods Enzastaurin was administered continuously once daily at 3 dose levels (260, 340, and 440 mg/m 2) and twice daily at 440 mg/m 2/day. Plasma pharmacokinetics were evaluated ...
https://utsouthwestern.pure.elsevier.com/en/publications/a-phase-1-and-pharmacokinetic-study-of-enzastaurin-in-pediatric-p
Obinutuzumab in Treating Patients With Central Nervous System Lymphoma Who Have Achieved a Complete Response | Clinical...Obinutuzumab in Treating Patients With Central Nervous System Lymphoma Who Have Achieved a Complete Response | Clinical...
Clinical trial for Central Nervous System B-Cell Non-Hodgkin Lymphoma | CD20 Positive , Obinutuzumab in Treating Patients With Central Nervous System Lymphoma Who Have Achieved a Complete Response
https://www.centerwatch.com/clinical-trials/listings/75762/cd20-positive-obinutuzumab-treating-patients-central/?section=elg&geo_lat=41.4847&geo_lng=-81.8018&radius=10
Advances in the treatment of newly diagnosed primary central nervous system lymphomasAdvances in the treatment of newly diagnosed primary central nervous system lymphomas
Despite scarce data on surgical treatment of PCNSL, the efforts at resection are generally discouraged. This viewpoint is based on small-scale retrospective studies, which attests that surgical resection per se holds no clear advantages over supportive care. There are a few explanations as to what shaped this outlook. First, PCNSL is an infiltrative tumor with a multifocal nature, which can expand beyond the visible margin of the macroscopic lesion and has a predilection for early wide dissemination [50]. Second, the striking responsiveness to chemotherapy and radiotherapy might have alleviated the desire of invasive procedures against this type of tumor. Another reason could be the improvement of imaging studies, making surgical resection for histologic confirmation unnecessary. Finally, the postoperative morbidity in this patient population could have played a key role in discouraging surgical resection [51].. However, this mindset is not grounded on either randomized data or contemporary ...
http://www.bloodresearch.or.kr/journal/view.html?uid=2074&vmd=Full
Prognostic factors for response and survival in primary central nervous system lymphoma (PCNSL) from a randomized phase III...Prognostic factors for response and survival in primary central nervous system lymphoma (PCNSL) from a randomized phase III...
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
https://www.oncolink.org/conferences/coverage/asco/oncolink-at-asco-2011/sunday-june-5-2011/prognostic-factors-for-response-and-survival-in-primary-central-nervous-system-lymphoma-pcnsl-from-a-randomized-phase-iii-trial-g-pcnsl-sg-1
BCL-6 Expression Predicts Improved Survival in Patients with Primary Central Nervous System Lymphoma | Clinical Cancer ResearchBCL-6 Expression Predicts Improved Survival in Patients with Primary Central Nervous System Lymphoma | Clinical Cancer Research
The cell of origin of lymphomas arising in the CNS, a site devoid of normal resident lymphoid tissue, has not been determined. Morphological (4) , immunophenotypic (4) , and molecular genetic (5) studies of PCNSL suggest that the cell of origin is related to the GC. Expression of BCL-6 is one feature that suggests a relationship to the GC. The BCL-6 protein is a zinc-finger transcriptional repressor encoded by the BCL-6 gene (12) . It is required for the formation of the GC (13) . In normal lymphoid tissue, there is nuclear expression of the BCL-6 protein almost exclusively by GC B cells. Lymphomas thought to be derived from GC cells, such as follicular lymphoma, also express BCL-6, whereas lymphomas derived from naïve (chronic lymphocytic leukemia and mantle cell lymphoma) or post-GC (marginal zone lymphomas, myeloma) B cells do not (14 , 15) .. Additional immunophenotypic markers that can aid in the characterization of lymphoid cells with respect to stage of B-cell differentiation were ...
http://clincancerres.aacrjournals.org/content/9/3/1063.long
Archives of Psychiatry and Psychotherapy - APPOnlineFirstNr3Archives of Psychiatry and Psychotherapy - APPOnlineFirstNr3
Primary central nervous system lymphoma is a rare neoplasm, exceptionally responsible for developing a frontal lobe syndrome. A 71-years-old patient with primary central nervous system lymphoma had undergone frontotemporal craniotomy for tumor removal. Month later, showing syncopies, disorientation and slurred speech, he was transported to Department of Internal Medicine. Neuroimaging revealed numerous tuberous changes in frontal and parietal lobes and frontotemporal area. During hospitalization, patient exhibited inadequate affect, jocular behaviour, was disoriented in the place and time, and unaware of his health state. He took repeated, uncritical attempts to jump out the window and started to exhibit persecutory delusions and hallucinations. Immediate brain radiotherapy was recommended by the oncology specialists. However, the patient did not consent to the recommended method of treatment due to his lack of recollection of the tumor or the craniotomy. The patient was forcibly transferred to ...
http://www.archivespp.pl/apponlinefirstnr3.html
Archives of Psychiatry and Psychotherapy - APPOnlineFirstNr3Archives of Psychiatry and Psychotherapy - APPOnlineFirstNr3
Primary central nervous system lymphoma is a rare neoplasm, exceptionally responsible for developing a frontal lobe syndrome. A 71-years-old patient with primary central nervous system lymphoma had undergone frontotemporal craniotomy for tumor removal. Month later, showing syncopies, disorientation and slurred speech, he was transported to Department of Internal Medicine. Neuroimaging revealed numerous tuberous changes in frontal and parietal lobes and frontotemporal area. During hospitalization, patient exhibited inadequate affect, jocular behaviour, was disoriented in the place and time, and unaware of his health state. He took repeated, uncritical attempts to jump out the window and started to exhibit persecutory delusions and hallucinations. Immediate brain radiotherapy was recommended by the oncology specialists. However, the patient did not consent to the recommended method of treatment due to his lack of recollection of the tumor or the craniotomy. The patient was forcibly transferred to ...
https://w.archivespp.pl/apponlinefirstnr3.html
Biology and treatment of primary central nervous system lymphoma
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
http://pubmedcentralcanada.ca/pmcc/articles/PMC4942275/
Impact of histologic subtypes and treatment modality among patients with primary central nervous system lymphoma: a SEER...Impact of histologic subtypes and treatment modality among patients with primary central nervous system lymphoma: a SEER...
https://doi.org/10.18632/oncotarget.25622 Dai Chihara, Nathan H. Fowler, Yasuhiro Oki, Michelle A. Fanale, Loretta J. Nastoupil, Jason R. Westin, Luis E. Fayad, Sattva S. Neelapu, Chan Yoon Cheah
https://www.oncotarget.com/article/25622/text/
MEDIA ADVISORY: Fifth Annual International Central Nervous System Germ Cell Tumor Conference :: Nationwide Childrens HospitalMEDIA ADVISORY: Fifth Annual International Central Nervous System Germ Cell Tumor Conference :: Nationwide Childrens Hospital
Named to the Top 10 Honor Roll on U.S. News & World Reports 2016-17 list of Americas Best Childrens Hospitals, Nationwide Childrens Hospital is Americas largest not-for-profit freestanding pediatric healthcare system providing wellness, preventive, diagnostic, treatment and rehabilitative care for infants, children and adolescents, as well as adult patients with congenital disease. Nationwide Childrens has a staff of more than 11,000 providing state-of-the-art pediatric care during more than 1.2 million patient visits annually. As home to the Department of Pediatrics of The Ohio State University College of Medicine, Nationwide Childrens physicians train the next generation of pediatricians and pediatric specialists. The Research Institute at Nationwide Childrens Hospital is one of the Top 10 National Institutes of Health-funded freestanding pediatric research facilities. More information is available at NationwideChildrens.org ...
http://www.nationwidechildrens.org/news-room-articles/media-advisory-fifth-annual-international-central-nervous-system-germ-cell-tumor-conference?contentid=163748
Central Nervous System Germ Cell Tumor - My Cancer Genome
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].. 2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.. 3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.. ...
https://www.mycancergenome.org/content/disease/central-nervous-system-germ-cell-tumor/
adult central nervous system germ cell tumor 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Investigator] Aghakhani N; Ali Benali M; Alliez B; Amat D; Amlashi A; Arbez-Gindre F; Arbion F; Assaker R; Aubriot Lorton MH; Auque J; Autricque A; Auvigne I; Averous G; Baldet P; Bataille B; Bazin A; Beaurain J; Benezech J; Bergemer Fouquet A; Besson G; Beuvon F; Billotet C; Blond S; Boetto S; Boissonnet H; Bonyhay G; Bouillot P; Bourgeois P; Bouvier C; Brassier G; Broche C; Brunon J; Cabal P; Cahn V; Caire F; Calvet P; Cazals-Hatem D; Chapon F; Chazal J; Civit T; Colnat S; Colombat M; Comoy J; Couvelard A; Czorny A; Dam Hieu P; Daumas-Duport C; Dautheribes M; David P; Debono B; Delage Corre M; Delhaye M; Delisle MB; Delsol G; Derlon JM; Desenclos C; Desplat A; Devaux B; Di Rocco F; Diaz A; Diebold MD; Dorfmuller G; Dran G; Dufour T; Dumas B; Dumollard JM; Durand L; Duthel R; Eimer S; El Fertit H; Emery E; Espagno C; Esposito P; Etchandy MP; Eyremandi RP; Faillot T; Felix S; Fernandez C; Fesselet J; Fontaine D; Fournier D; François P; Froelich S; Fuentes JM; Fuentes S; Gadan R; Gaspard C; Gay ...
http://www.bmlsearch.com/?kwr=adult+central+nervous+system+germ+cell+tumor+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies<...
TY - JOUR. T1 - Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies. AU - Choi, John. AU - Rui, Yuan. AU - Kim, Jayoung. AU - Gorelick, Noah. AU - Wilson, David R.. AU - Kozielski, Kristen. AU - Mangraviti, Antonella. AU - Sankey, Eric. AU - Brem, Henry. AU - Tyler, Betty. AU - Green, Jordan J.. AU - Jackson, Eric M.. PY - 2020/1. Y1 - 2020/1. N2 - Together, medulloblastoma (MB) and atypical teratoid/rhabdoid tumors (AT/RT) represent two of the most prevalent pediatric brain malignancies. Current treatment involves radiation, which has high risks of developmental sequelae for patients under the age of three. New safer and more effective treatment modalities are needed. Cancer gene therapy is a promising alternative, but there are challenges with using viruses in pediatric patients. We developed a library of poly(beta-amino ester) (PBAE) nanoparticles and evaluated their efficacy for plasmid delivery of a suicide gene therapy to pediatric brain cancer ...
https://jhu.pure.elsevier.com/en/publications/nonviral-polymeric-nanoparticles-for-gene-therapy-in-pediatric-cn
Blood-Brain Barrier Disruption Chemotherapy<...Blood-Brain Barrier Disruption Chemotherapy<...
TY - CHAP. T1 - Blood-Brain Barrier Disruption Chemotherapy. AU - McGregor, John M.. AU - Bell, Susan D.. AU - Doolittle, Nancy. AU - Murillo, Tulio P.. AU - Neuwelt, Edward. PY - 2018/4/24. Y1 - 2018/4/24. N2 - The goal of chemotherapy administered in conjunction with blood-brain barrier disruption (BBBD) is maximizing drug delivery to the brain, while preserving the neurocognitive function and minimizing systemic toxicity. In the clinic, BBBD has shown promising results in chemosensitive brain tumors such as the primary central nervous system lymphoma (PCNSL) and offers a new strategy for global delivery of chemotherapy to tumors such as anaplastic oligodendroglioma and central nervous system metastases. Multicenter clinical trials using BBBD are in progress at centers participating in the blood-brain barrier (BBB) Consortium. Current and future clinical studies include delivery of mAbs across the BBB and novel imaging agents to monitor therapeutics.. AB - The goal of chemotherapy administered ...
https://ohsu.pure.elsevier.com/en/publications/blood-brain-barrier-disruption-chemotherapy-3
Primary Cns Lymphoma: Current Diagnosis and Management | MedCrave
Induction chemotherapy. High dose Methotrexate: The efficacy of Methotrexate in the treatment of Primary CNS lymphoma was first demonstrated by Ervin & Canellos in 1980 [17]. The primary CNS lymphoma cells inside brain are more sensitive to MTX and thus HD-MTX forms the backbone of PCNL therapy. HD-MTX is also shown a treatment related prognostic marker for survival in these patients [18]. There is no firm definition of HD-MTX and doses from 1g/m2 to 8 g/m2 has been reported in clinical trials [19]. Importantly Lippens and colleagues [20] demonstrated that intravenous administration of Methotrexate over 3 hours (3g/m2) leads to superior concentrations in cerebrospinal fluid (CSF) than infusion over 24 hours. Despite detectable meningeal disease in up to 15 % patients at diagnosis, intrathecal therapy has failed to achieve significantly better outcome [21]. Glantz et al demonstrated higher CSF levels after intravenous Methotrexate (8g/m2) than intrathecal injection with 12g/m2 Methotrexate [16]. ...
http://googlescholar.medcraveonline.com/scholars/article_fulltext/3447
SETD2 mutations in primary central nervous system tumors | Acta Neuropathologica Communications | Full TextSETD2 mutations in primary central nervous system tumors | Acta Neuropathologica Communications | Full Text
Mutations in SETD2 are found in many tumors, including central nervous system (CNS) tumors. Previous work has shown these mutations occur specifically in high grade gliomas of the cerebral hemispheres in pediatric and young adult patients. We investigated SETD2 mutations in a cohort of approximately 640 CNS tumors via next generation sequencing; 23 mutations were detected across 19 primary CNS tumors. Mutations were found in a wide variety of tumors and locations at a broad range of allele frequencies. SETD2 mutations were seen in both low and high grade gliomas as well as non-glial tumors, and occurred in patients greater than 55 years of age, in addition to pediatric and young adult patients. High grade gliomas at first occurrence demonstrated either frameshift/truncating mutations or point mutations at high allele frequencies, whereas recurrent high grade gliomas frequently harbored subclones with point mutations in SETD2 at lower allele frequencies in the setting of higher mutational burdens.
https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0623-0/figures/1
Turkish Neurosurgery
University of Occupational and Environmental Health, Department of Neurosurgery, Kitakyushu, Japan DOI : 10.5137/1019-5149.JTN.10594-14.1 5-Aminolevulinic acid (5-ALA)-induced fluorescence-guided resection is a widely used procedure for patients with malignant gliomas. However, the clinical application of 5-ALA for surgery in primary central nervous system lymphoma (PCNSL) is uncommon. Here, we present a case of PCNSL treated using 5-ALA-induced fluorescence-guided resective surgery. A 70-year-old woman presented with cerebellar ataxia, and magnetic resonance imaging revealed an irregularly shaped and homogenously enhanced mass with surrounding brain edema in the vermis that extended to the right hemisphere of the cerebellum. Under the preoperative diagnosis of a malignant glioma in the cerebellum, the patient underwent 5-ALA-induced fluorescence-guided surgery. Under blue light illumination, the tumor revealed strong 5-ALA-induced fluorescence. The tumor was identified as a diffuse large B-cell ...
http://www.turkishneurosurgery.org.tr/abstract.php?lang=en&id=1593
CTLA-4 polymorphisms and predisposition to digestive system malignancies: a meta-analysis of 31 published studies | World...CTLA-4 polymorphisms and predisposition to digestive system malignancies: a meta-analysis of 31 published studies | World...
The results of genetic association studies regarding cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) polymorphisms and digestive system malignancies were controversial. The authors designed this meta-analysis to more precisely estimate relationships between CTLA-4 polymorphisms and digestive system malignancies by pooling the results of related studies. The authors searched PubMed, Embase, Web of Science, and CNKI for eligible studies. Thirty-one eligible studies were pooled analyzed in this meta-analysis. The pooled meta-analysis results showed that genetic distributions of rs231775, rs4553808, and rs733618 polymorphisms among patients with digestive system malignancies and controls differed significantly. Moreover, genotypic distribution differences were also observed for rs231775 polymorphism among patients with colorectal cancer/pancreatic cancer and controls, for rs4553808 and rs5742909 polymorphisms among patients with gastric cancer and controls, for rs3087243 polymorphism among patients
https://wjso.biomedcentral.com/articles/10.1186/s12957-020-1806-2
Moran CORE | Ocular Lymphoma: My Left Eye is BlindMoran CORE | Ocular Lymphoma: My Left Eye is Blind
Brief Description: This is a case report of an elderly male who presented with sudden, painless loss of vision in one eye and a history of B-cell lymphoma, previously treated with chemotherapy. He was diagnosed with primary central nervous system lymphoma and ocular lymphoma. A review of ocular lymphoma diagnosis, pathophysiology, and management is undertaken ...
http://morancore.utah.edu/ophthalmic-pathology-old/ocular-lymphoma-my-left-eye-is-blind/
Huge congnitive losses due to treatment | Cancer Survivors NetworkHuge congnitive losses due to treatment | Cancer Survivors Network
My mom (only 54 years old) has Primary Central Nervous System Lymphoma. She has undergone various chemo treatments for over three years. Now, there is no sign of the tumor, but she is suffering great losses due to the treatment. In the last 6 months my moms congnitive abilities have drastically declined. She has completely lost her short-term memory, she can no longer express herself verbally (inability to recall words), she is easily agitated, and very depressed. All of these symptoms/reactions are devastating to my mom and our family. Clearly, she can no longer live on her own or care for herself. Right now, we are looking into nursing/assisted living care facilities. Has anyone else suffered such huge losses due to chemo treatment? What did you do? Does any form of detox help? Also, does anyone have recommendations for nursing/assisted living facilities (for cancer survivors or individuals with severe brain impairments) in the Los Angeles and/or San Diego area? Thanks for your help. ...
https://csn.cancer.org/comment/663262
Comparison of visual acuity improvement by vitrecotmy for vitreous opacity between infections and non-infectious uveitis | IOVS...Comparison of visual acuity improvement by vitrecotmy for vitreous opacity between infections and non-infectious uveitis | IOVS...
Retrospective, single-practice data analysis from a medical record system. Forty-one eyes of 31 patients, in which diagnostic or therapeutic vitrectomy was performed for VO between April 2012 and March 2015 in National Defense Medical College, were reviewed. Twelve eyes of 10 patients were infectious uveitis (males/females; 5/5, average age ± standard deviation; 71.8 ± 10.8 years old, primary top 3 diseases; endophthalmitis 5 eyes, cytomegalovirus retinitis 3 eyes, acute retinal necrosis 1 eye, ocular toxoplasmosis 1 eye), and 29 eyes of 21 patients were noninfectious uveitis (males/females; 3/18, average age; 64.0 ± 12.2 years old, primary top 3 diseases; sarcoidosis 9 eyes, primary central nervous system lymphoma 4 eyes, Behcets disease 2 eyes). BCVA before surgery and at 1, 3, and 6 months after surgery were converted to logMAR, and improvement rate of logMAR were evaluated by the ratio of postoperative logMAR to preoperative logMAR at the individual time points ...
http://iovs.arvojournals.org/article.aspx?articleid=2638681
Clinical Oncology - Oxford MedicineClinical Oncology - Oxford Medicine
The Oxford Textbook of Neuro-Oncology examines the epidemiology, pathogenesis, clinical features, and management of adult and childhood central nervous system (CNS) tumours. The book is organized according to the World Health Organization (WHO) classification of CNS tumours and includes an introductory chapter discussing the new, revised WHO classification that will be used in future editions of this textbook. The book reviews primary CNS tumours, metastatic CNS tumours, and familial tumour syndromes. Each chapter is organized according to a uniform framework, addressing epidemiology, aetiology, pathogenesis, clinical presentation, imaging, and treatment, with a focus on different treatment modalities and specific consideration of paediatric aspects, where applicable. Each chapter is authored by a multidisciplinary, international group of senior specialists representing the United States, Canada, Europe, and the Asia/Pacific region. It is written for generalists and specialists managing these ...
http://oxfordmedicine.com/browse?btog=book&pageSize=10&sort=titlesort&t=OXMEDO_SPECIALTY%3AMED00880&t0=OXMEDO_SPECIALTY%3AMED00310
Pharmacokinetics of O6-benzylguanine in Pediatric Patients with Central Nervous System Tumors | Clinical Cancer ResearchPharmacokinetics of O6-benzylguanine in Pediatric Patients with Central Nervous System Tumors | Clinical Cancer Research
High levels of AGAT activity are common in adult brain tumors (12, 13, 14) and may be correlated with poor responses to alkylator-based chemotherapy and decreased time to treatment failure and death (12 , 15 , 16) . High levels of AGAT have also been observed in pediatric brain tumors, including gliomas, medulloblastomas, primitive neuroectodermal tumors, and ependymomas (13) . These observations may explain why nitrosourea-based chemotherapy has had little impact on survival in common pediatric brain tumors (17 , 18) . Therefore, a strategy to inactivate AGAT before administration of an aklyating agent is a logical pursuit for adult and pediatric central nervous system tumors.. We found that O6BG is rapidly eliminated with a half-life of 85 ± 140 min after i.v. administration. In contrast 8-oxo-O6BG, an active metabolite, appears rapidly in plasma after O6BG administration and has a prolonged half-life of approximately 6 h. In most patients, the combined concentrations of O6BG and 8-oxo-O6BG ...
http://clincancerres.aacrjournals.org/content/10/15/5072.full
Neurolymphomatosis: an International Primary CNS Lymphoma Collaborative Group report - Zurich Open Repository and ArchiveNeurolymphomatosis: an International Primary CNS Lymphoma Collaborative Group report - Zurich Open Repository and Archive
Neurolymphomatosis (NL) is a rare clinical entity. The International Primary CNS Lymphoma Collaborative Group retrospectively analyzed 50 patients assembled from 12 centers in 5 countries over a 16-year period. NL was related to non-Hodgkin lymphoma in 90% and to acute leukemia in 10%. It occurred as the initial manifestation of malignancy in 26% of cases. The affected neural structures included peripheral nerves (60%), spinal nerve roots (48%), cranial nerves (46%), and plexus (40%) with multiple site involvement in 58%. Imaging studies often suggested the diagnosis with 77% positive magnetic resonance imaging, and 84% (16 of 19) positive computed tomography-positron emission tomography studies. Cerebrospinal fluid cytology was positive in 40%, and nerve biopsy confirmed the diagnosis in 23 of 26 (88%). Treatment in 47 patients included systemic chemotherapy (70%), intra-cerebrospinal fluid chemotherapy (49%), and radiotherapy (34%). Response to treatment was observed in 46%. The median overall ...
http://www.zora.uzh.ch/id/eprint/35509/
Adult primary central nervous system vasculitis treatment and course: analysis of one hundred sixty-three patients | Archivio...Adult primary central nervous system vasculitis treatment and course: analysis of one hundred sixty-three patients | Archivio...
Objective. To describe the treatment and outcomes of patients with primary central nervous system (CNS) vasculitis. Methods. We retrospectively studied a cohort of 163 consecutive patients with primary CNS vasculitis who were seen at the Mayo Clinic over a 29-year period. We analyzed treatments, treatment responses, and factors predictive of outcomes. Results. A favorable response was observed in 85% of patients treated with prednisone alone and in 80% of patients treated with prednisone and cyclophosphamide. Relapses were observed in 27% of patients, and 25% of patients had discontinued therapy by the time of the last followup visit. Treatment with prednisone alone was associated with more frequent relapses (odds ratio [OR] 2.90), while large vessel involvement (OR 6.14) and cerebral infarcts at the time of diagnosis (OR 3.32) were associated with a poor response to treatment. Prominent gadolinium-enhanced cerebral lesions or meninges were linked with continued treatment at the last followup ...
https://iris.unimore.it/handle/11380/1079756
CNS Lymphoma - Columbia NeurosurgeryCNS Lymphoma - Columbia Neurosurgery
Central nervous system (CNS) lymphoma is a condition in which malignant cells are present in the lymph tissue of the brain and/or spinal cord. Treatment for CNS lymphoma generally does not include surgery. Instead, nonsurgical treatments, namely corticosteroids, chemotherapy and/or whole-brain radiation therapy, are used to treat CNS lymphoma.. Lymphoma designates a group of cancers that arise from white blood cells called lymphocytes. Because lymphocytes travel in the blood and lymph tissue and pass in and out of the CNS, lymphoma too can develop in various places in the body, including the CNS. CNS lymphoma is an aggressive type of lymphoma.. CNS lymphoma comes in two forms, depending on the origin of the tumor, and can produce single or multiple growths. ...
http://www.columbianeurosurgery.org/conditions/cns-lymphoma/
Primary CNS Lymphoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Forrest HealthPrimary CNS Lymphoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Forrest Health
Primary central nervous system (CNS) lymphoma is a disease in which malignant (cancer) cells form in the lymph tissue of the brain and/or spinal cord. Lymphoma is a disease in which malignant (cancer) cells form in the lymph system. The lymph system is part of the immune system and is made up of the lymph, lymph...
http://www.forresthealth.org/health-library/healthwise-document-viewer/?id=ncicdr0000258030
Amyloid Precursor Protein Secretases | Colorado PROFILES
Hoffman LM, Fouladi M, Olson J, Daryani VM, Stewart CF, Wetmore C, Kocak M, Onar-Thomas A, Wagner L, Gururangan S, Packer RJ, Blaney SM, Gajjar A, Kun LE, Boyett JM, Gilbertson RJ. Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study. Childs Nerv Syst. 2015 Aug; 31(8):1283-9 ...
https://profiles.ucdenver.edu/display/209117
CNS lymphoma | Radiology Reference Article | Radiopaedia.orgCNS lymphoma | Radiology Reference Article | Radiopaedia.org
CNS lymphoma refers to the involvement of the central nervous system with lymphoma. It can be broadly divided into primary and secondary, with a number of special types of also recognised. primary CNS lymphoma (PCNSL) intravascular lymphoma M...
https://radiopaedia.org/articles/cns-lymphoma-1
https://www.cancer.gov/types/brain/patient/child-cns-germ-cell-treatment-pdqhttps://www.cancer.gov/types/brain/patient/child-cns-germ-cell-treatment-pdq
Childhood central nervous system (CNS) germ cell tumors form from germ cells (a type of cell that forms as a fetus develops and later becomes sperm in the testicles or eggs in the ovaries). Learn about the signs, tests to diagnose, and treatment of pediatric germ cell tumors in the brain in this expert-reviewed summary.
https://www.cancer.gov/types/brain/patient/child-cns-germ-cell-treatment-pdq
Viagra at 30 for prednisone with out prescriptionViagra at 30 for prednisone with out prescription
Per usion is started in all children including neonates, complete seizure 30 viagra at reedom in o patients. Patients often present insidiously. New york cambridge university press. Other common adverse effects eg, weight loss, exercise, and behavior o the disease. Such testing is commonly disrupted among migraineurs. Case critically ill neonates iv= intravenous cns =central nervous system metastases has been shown for pediatric ophthalmology and strabismus. Patients who are trained in neurology is consulted and opt or conservative use of oral or iv ergotamine agents are much more hypoechoic than the usual dose of aeds should be used for the treatment of adhd medication should be. Many di erent classes at the receptor site include alterations in blood pressure goal for a treatment disadvantage. The cells are contained in endogenous estrogen, bone remodeling accelerates during menopause, and up to once daily twice daily fish oil are only appropriate for occasional moderatesevere flares or ...
https://medpsychmd.com/nurse/viagra-at-30/63/
Panitumumab - wikidocPanitumumab - wikidoc
Study 3 was a multicenter, open-label trial that randomized (1:1) patients with mCRC who were previously untreated in the metastatic setting and who had received no prior oxaliplatin to receive Panitumumab every 14 days in combination with FOLFOX or to FOLFOX alone every 14 days. Panitumumab was administered at 6 mg/kg over 60 minutes prior to administration of chemotherapy. The FOLFOX regimen consisted of oxaliplatin 85 mg per m2 IV infusion over 120 minutes and leucovorin (dl-racemic) 200 mg per m2 intravenous infusion over 120 minutes at the same time on day 1 using a Y-line, followed on day 1 by 5-FU 400 mg per m2 intravenous bolus. The 5FU bolus was followed by a continuous infusion of 5-FU 600 mg per m2 over 22 hours. On day 2, patients received leucovorin 200 mg per m2 followed by the bolus dose (400 mg per m2) and continuous infusion of 5FU (600 mg per m2) over 22 hours. Study 3 excluded patients with known central nervous system metastases, clinically significant cardiac disease, ...
http://www.wikidoc.org/index.php/Vectibix
Primary leptomeningeal lymphoma: International Primary CNS lymphoma collaborative group report - Fingerprint - NYU Scholars
Jennie W. Taylor, Eoin P. Flanagan, Brian P. ONeill, Tali Siegal, Antonio Omuro, Lisa DeAngelis, Joachim Baehring, Ryo Nishikawa, Fernando Pinto, Marc Chamberlain, Khe Hoang-Xuan, Alberto Gonzalez-Aguilar, Tracy Batchelor, Jean Yves Blay, Agnieszka Korfel, Rebecca A. Betensky, Maria Beatriz S. Lopes, David Schiff ...
https://nyuscholars.nyu.edu/en/publications/primary-leptomeningeal-lymphoma-international-primary-cns-lymphom/fingerprints/?sortBy=alphabetically
Plus itPlus it
AT/RTs are rare malignant intracranial tumors, representing only 1.3% of primary CNS tumors in the pediatric population and 6.7% of CNS tumors in children younger than 2 years.2 Malignant rhabdoid tumors can occur in many locations in the body, though the kidney and CNS are the most common primary sites.3 Within the CNS, 38%-65% have been reported to be infratentorial, 27%-62% in supratentorial locations, and 4%-8% occurring in multiple CNS sites at diagnosis.1,3,9. Rhabdoid cells in AT/RT observed with light microscopy are often plump with eccentric round nuclei containing prominent nucleoli within fibrillary or granular eosinophilic cytoplasm, though rhabdoid tumor cells can also be small and spindle-shaped with ovoid nuclei or large, containing nuclei with wrinkled margins.1,3,5,11 Abundant mitotic figures, necrosis, hemorrhage, and ill-defined margins with adjacent brain are common histologic feature seen in AT/RT.1,3,5,11 In addition to the rhabdoid tumor cells, intracranial AT/RTs often ...
http://www.ajnr.org/content/27/5/962
Brain Tumors - RTAnswers.orgBrain Tumors - RTAnswers.org
The brain is the center of thought, memory, emotion, speech, sensation and motor function. The spinal cord and special nerves called cranial nerves carry and receive messages between the brain and the rest of the body. Brain tumors cause damage because, as they grow, they can interfere with surrounding cells that serve vital roles in our everyday life.. The Central Brain Tumor Registry of the United States estimates that more than 688,096 persons are living with a diagnosis of primary brain and central nervous system tumors in the United States.. An estimated 77,670 new cases of primary benign and malignant brain and central nervous system tumors are expected to be diagnosed in the United States in 2017.. ...
http://www.rtanswers.org/braintumors/
Fighting a rare central nervous system tumor with research and optimism | Center for Cancer Research - National Cancer InstituteFighting a rare central nervous system tumor with research and optimism | Center for Cancer Research - National Cancer Institute
In January 2016, Sarah Rosenfeld had such severe pain shooting down her legs she couldnt walk, sleep or care for her young daughters. After weeks of physical therapy for what she thought was sciatica, she had an MRI. Thirty-seven-year-old Rosenfeld learned she had something far worse: myxopapillary ependymoma, a rare cancerous tumor in her spinal cord. She came to the NIH for
https://ccr.cancer.gov/news/article/fighting-a-rare-central-nervous-system-tumor-with-research-and-optimism
Follow-up After Treatment of Central Nervous System Tumors Occurring During Infancy - The ISPN Guide to Pediatric NeurosurgeryFollow-up After Treatment of Central Nervous System Tumors Occurring During Infancy - The ISPN Guide to Pediatric Neurosurgery
CSF cytology via lumbar puncture: If the primary tumor was exposed to the CSF compartment (or arose in it), lumbar CSF should be examined for cytology 7-14 days after surgery to exclude CSF dissemination unless there was preoperative evidence of leptomeningeal disease. ...
https://www.ispn.guide/tumors-of-the-nervous-system-in-children/central-nervous-system-tumors-occurring-during-infancy/management-of-central-nervous-system-tumors-occurring-during-infancy/follow-up-after-treatment-of-central-nervous-system-tumors-occurring-during-infancy/
Lyme neuroborreliosis mimicking primary CNS lymphomaLyme neuroborreliosis mimicking primary CNS lymphoma
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively ...
https://epub.ub.uni-muenchen.de/16802/
Central Nervous System Tumor Derived Exosomes Suppress an Anti-Tumor Response | Exosome RNACentral Nervous System Tumor Derived Exosomes Suppress an Anti-Tumor Response | Exosome RNA
ImmunoChemistry Technologies. In this webinar, learn how escaping immune system surveillance is a major obstacle for immunotherapies against cancer. Tumor cells secrete soluble factors allowing them to escape immune surveillance. Exosomes, or small vesicular structures excreted by normal cells, have a plethora of biological significance as these exosomes play a significant role in intracellular communication and help in the activation of immune response. However, in the case of cancer, exosomes secreted by tumor cells can induce apoptosis of activated T cells or impair the differentiation of monocytes to myeloid derived suppressor cells. We found out that tumor derived exosomes inhibit antigen specific proliferation and induce B cell hyperactivation, but are functionally suppressed. We also investigated whether TLR4 mediated signaling has a major role in this immune suppression.. ...
http://www.exosome-rna.com/central-nervous-system-tumor-derived-exosomes-suppress-an-anti-tumor-response/
April 2014 | School of Medicine | West Virginia UniversityApril 2014 | School of Medicine | West Virginia University
Primary CNS lymphomas (PCNSL) are defined as extranodal lymphomas arising within the CNS in the absence of lymphoma outside the CNS at the time of diagnosis. PCNSL in immunocompetent individuals are rare and account for approximately 5% of all brain tumors and , 1% of Non-Hodgkin lymphomas. Males are affected more than females with a ratio of 3:2 [1,2]. Immunodeficiency disorders such as Wiskott-Aldrich and AIDS predispose to the development of PCNSL. The Epstein-Barr virus (EBV) genome is found in more than 95% of immunocompromised patients and only in 0-20% of immunocompetent patients [2]. Most patients present with focal neurological deficits and around 5-20% present with seizures. MRI is the most sensitive radiologic modality for the detection of CNS lymphomas. It characteristically shows single or multiple enhancing lesions which can be seen in other brain lesions such as glioblastomas, brain abscesses, and metastatic carcinomas ...
http://medicine.hsc.wvu.edu/pathology/case-of-the-month/2014/april-2014/
Lymphoma Action | Hopeful results for secondary CNS lymphomaLymphoma Action | Hopeful results for secondary CNS lymphoma
Secondary CNS lymphoma is lymphoma that starts somewhere else in the body but spreads to the brain or spinal cord (central nervous system, or CNS). This can happen either before the lymphoma is diagnosed, or if it comes back (relapses) after initial treatment. Secondary CNS lymphoma is difficult to treat. At the moment, there are no standard treatment options, and outcomes are generally poor.
https://lymphoma-action.org.uk/hopeful-results-secondary-cns-lymphoma
Clinical Controversies of Double-Hit Lymphoma | Gotoper.comClinical Controversies of Double-Hit Lymphoma | Gotoper.com
Controversy #3: Should all patients receive intrathecal prophylaxis for central nervous system disease?. A clinical dilemma is whether these patients require central nervous system (CNS) prophylaxis. Multiple cases of an increased incidence of CNS involvement have been reported. A small study described 40 patients with DLBCL with leukemic-phase disease, 14 of whom had CNS disease. Eight of these patients had FISH-confirmed double-hit lymphoma. In logistic regression analysis, double-hit status was found to be the one independent factor correlated with CNS involvement.19 In the MD Anderson experience, the incidence of CNS involvement at diagnosis was 4%, with a cumulative incidence of CNS involvement of 13% at 3 years. In patients who did not have documented CNS disease at the time of diagnosis, the incidence of eventual CNS involvement was lower. in those receiving prophylactic intrathecal therapy (5% at 3 years) than in those who did not (15% at 3 years; P =.017).8 At this time, secondary to ...
http://www.gotoper.com/publications/ajho/2015/2015Apr/Clinical-Controversies-of-Double-Hit-Lymphoma
Immunotherapy advances for glioblastomaImmunotherapy advances for glioblastoma
Immunotherapy advances for glioblastoma Neuro-Oncology - current issue Survival for patients with glioblastoma, the most common high-grade primary CNS tumor,
http://weneuro.com/immunotherapy-advances-for-glioblastoma/
Intermittent central nervous system irradiation and intrathecal chemotherapy for recurrent central nervous system leukemia in...Intermittent central nervous system irradiation and intrathecal chemotherapy for recurrent central nervous system leukemia in...
Between 1986 and 1990, four children with recurrent CNS leukemia who had previous CNS prophylaxis therapy were treated with intermittent central nervous system irradiation and intrathecal chemotherapy (IIIC). There was no isolated CNS recurrence. One patient died form bone marrow relapse. Three patients are alive without evidence of disease for 3E3/12 year to 3E6/12 year after the diagnosis of recurrence of CNS leukemia. This experience suggests that IIIC may be an effective treatment for preventing the recurrence of CNS leukemia without any serious side effects. ...
https://koreamed.org/article/1052KJP/1993.36.8.1067
Therapy regimens for treatment of patients with Central Nervous System (CNS) relapses and Secondary CNS Lymphoma | Lymphoma HubTherapy regimens for treatment of patients with Central Nervous System (CNS) relapses and Secondary CNS Lymphoma | Lymphoma Hub
Central Nervous System (CNS) relapses and Secondary CNS Lymphoma - A.J.M. Ferreri presents treatment regimens for these patients in a multidisciplinary cases session at ESMO 2016
http://www.lymphomahub.com/medical-information/esmo-2016-multidisciplinary-cases-session-therapy-regimens-for-treatment-of-patients-with-central-nervous-system-cns-relapses-and-secondary-cns-lymphoma
R-MPV Acronym | Chemotherapy Regimen for CNS Lymphoma | Chemocare.comR-MPV Acronym | Chemotherapy Regimen for CNS Lymphoma | Chemocare.com
R-MPV is most often associated with treatment of CNS Lymphoma. Drugs involved: Rituximab, Methotrexate, Leucovorin, Procarbazine, Vincristine
http://www.chemocare.com/chemotherapy/acronyms/r-mpv.aspx
CNS lymphoma and demyelination | Radiology Case | Radiopaedia.orgCNS lymphoma and demyelination | Radiology Case | Radiopaedia.org
The diagnosis of lymphoma is not always straight forward, and in this case it remains difficult to know whether the two processes were coincidental or more likely related to each other. Demyelination preceding a CNS lymphoma is a recognised phen...
https://radiopaedia.org/cases/cns-lymphoma-and-demyelination
Long-term outcome is better when a methotrexate-based treatment strategy is combined with 10 mg prednisone daily: follow-up...Long-term outcome is better when a methotrexate-based treatment strategy is combined with 10 mg prednisone daily: follow-up...
Results Of 218 patients post-trial follow-up data were available. The maximum follow-up time was 11.8 years. Fewer patients initiated a first bDMARD in the former MTX+pred compared with the former MTX+plac strategy group: 31% vs 50%, p=0.003. At the 2 year post-trial follow-up, the median erosion score was significantly lower in the former MTX+pred versus former MTX+plac strategy group: 0 (range 0-0) versus 0 (0-2), p=0.002. No significant differences between the former strategy groups in the onset of GC-related comorbidities during the post-trial follow-up were found. ...
http://ard.bmj.com/content/76/8/1432
JoVE Search Results: Central Nervous System Neoplasms
Cancer, Risk, Survivors, Screening, Health, Acute Lymphoblastic Leukemia, Leukemia, Lymphoblastic Leukemia, Treatment, Children, Neoplasms, and Radiotherapy
http://labindex.jove.com/group/Central-Nervous-System-Neoplasms
Search Articles | University of Toronto Libraries
by Ferreri, A. J.M and Dognini, G. P and Campo, E and Willemze, R and Seymour, J. F and Bairey, O and Martelli, M and De Renzo, A and Doglioni, C and Montalban, C and Tedeschi, A and Pavlovsky, A and Morgan, S and Uziel, L and Ferracci, M and Ascani, S and Gianelli, U and Patriarca, C and Facchetti, F and Dalla Libera, A and Pertoldi, B and Horvath, B and Szomor, A and Zucca, E and Cavalli, F and Ponzoni, M and on behalf of the International Extranodal Lymphoma Study Group (IELSG) and International Extranodal Lymphoma Study Group (IELSG) and IELSG Grp ...
https://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:Brain%20Neoplasms%20-%20epidemiology
Turkish Neurosurgery
Primary Cns Lymphoma in Immunocompetent: A Review of Literature and Our Experience from Kashmir Rumana MAKHDOOMI, Khursheed NAYIL, Ahmad RAYEES, Altaf KIRMANI, Altaf RAMZAN, Muhammad Baba KHALIL, Anil DHAR, Syed BESINA, Nasima CHANDA, Abdul Rashid LONE, Sumaira QADIRI, Muhammad MAQBOOL Abstract ...
http://turkishneurosurgery.org.tr/content.php?id=60
Herceptin (Trastuzumab) for Breast Cancer Linked to CNS MetastasesHerceptin (Trastuzumab) for Breast Cancer Linked to CNS Metastases
During the past decade it has been frequently observed that patients with breast cancer treated with a taxane-containing chemotherapy regimen, either in the adjuvant setting or in the metastatic setting, presenting central nervous system (CNS) involvement as the only evidence of disease progression. More studies were therefore interested to evaluate the incidence of CNS metastases in patients with early and advanced breast cancer treated with a taxane-containing chemotherapy regimen and to
http://braintalkcommunities.org/showthread.php/3226-Herceptin-
Managing CNS Metastases in EGFR-Positive NSCLCManaging CNS Metastases in EGFR-Positive NSCLC
Panelists Suresh S. Ramalingam, MD, and Giorgio Scagliotti, MD, PhD, describe the prevalence of CNS metastases and the approach to management in patients with |em|EGFR|/em|-positive non–small cell lung cancer.
http://www.onclive.com/peer-exchange/advanced-nonsquamous-nsclc/managing-cns-metastases-in-egfr-positive-nsclc?sp=brain-cancer
Brain metastasisBrain metastasis
Percy AK, Elveback LR, Okazaki H, Kurland LT (January 1972). "Neoplasms of the central nervous system. Epidemiologic ... 1-19, ISBN 9780470753064 Kintomo T (1982). Metastatic tumors of the central nervous system. Igaku-Shoin. ISBN 978-0896400672. ... Neoplasm Metastasis Cancer Brain tumor Tse V (10 November 2009). "Brain Metastasis". Medscape. Retrieved 13 January 2010. " ... in the Metropolitan Detroit Cancer Surveillance System". Journal of Clinical Oncology. 22 (14): 2865-72. doi:10.1200/jco. ...
https://en.wikipedia.org/wiki/Brain_metastasis
Nervous system neoplasmNervous system neoplasm
Types include: Nerve sheath tumor Brain tumor Arachnoid cyst Optic nerve glioma "neoplasm of the central nervous system ( ... A nervous system neoplasm is a tumor affecting the nervous system. ... Nervous system neoplasia, All stub articles, Nervous system disease stubs, Neoplasm stubs). ...
https://en.wikipedia.org/wiki/Nervous_system_neoplasm
GlioblastomaGlioblastoma
"A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option". ... The new 2016 WHO Classification of Tumors of the Central Nervous System was a paradigm shift: some of the tumors were defined ... However, metastasis of GBM beyond the central nervous system is extremely unusual. About 50% of GBMs occupy more than one lobe ... It is the second-most common central nervous system cancer after meningioma. It occurs more commonly in males than females. ...
https://en.wikipedia.org/wiki/Glioblastoma
Wernickes areaWernicke's area
... infections affecting the central nervous system, neurodegenerative disease, and neoplasms. A cerebrovascular event is more ...
https://en.wikipedia.org/wiki/Wernicke's_area
Lead poisoningLead poisoning
... neoplasms of the central nervous system, emotional and behavior disorders, and intellectual disability. The current reference ... and the central nervous system. Peripheral nervous system effects are more prominent in adults and central nervous system ... Effects of lead on the physiology of the kidneys and blood are generally reversible; its effects on the central nervous system ... Central nervous system and neuromuscular symptoms usually result from intense exposure, while gastrointestinal symptoms usually ...
https://en.wikipedia.org/wiki/Lead_poisoning
Neuroectodermal neoplasmNeuroectodermal neoplasm
They are most commonly tumors in the central or peripheral nervous system.[citation needed] Tumors exhibiting neuroectodermal ... A neuroectodermal neoplasm is a neoplasm or tumor of the neuroectoderm. ... They include pituitary adenoma and carcinoid tumor Group II tumors/neoplasms: nonepithelial neuroectodermal neoplasms. These ... Nervous system neoplasia, All stub articles, Oncology stubs). ... "Neuroectodermal Neoplasms of the Head and Neck with Emphasis on ...
https://en.wikipedia.org/wiki/Neuroectodermal_neoplasm
Angiocentric gliomaAngiocentric glioma
"Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, ... Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (2016). WHO classification of tumours of the central nervous system (Revised 4th ed ... In 2007, the Fourth Edition of the World Health Organization Classification of Tumors of the Central Nervous System recognized ... June 2016). "The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary". Acta ...
https://en.wikipedia.org/wiki/Angiocentric_glioma
Lesional demyelinations of the central nervous systemLesional demyelinations of the central nervous system
They look like intracranial neoplasms, and sometimes they get biopsied as suspected tumors. Proton MR spectroscopy can help in ... However, in a person with MS, these cells recognize healthy parts of the central nervous system as foreign and attack them as ... Multiple sclerosis and other demyelinating diseases of the central nervous system (CNS) produce lesions (demyelinated areas in ... "Demyelinating diseases of the central nervous system". Medicine. 11 (77): 4601-4609. doi:10.1016/j.med.2015.04.001. Poser C. M ...
https://en.wikipedia.org/wiki/Lesional_demyelinations_of_the_central_nervous_system
Central nervous system cavernous hemangiomaCentral nervous system cavernous hemangioma
Benign neoplasms). ... cavernous hemangioma that arises in the central nervous system ... they are hooked into the venous side of the circulatory system), they will be angiographically occult (invisible). If a lesion ...
https://en.wikipedia.org/wiki/Central_nervous_system_cavernous_hemangioma
List of ICD-9 codes 140-239: neoplasmsList of ICD-9 codes 140-239: neoplasms
200.2 Burkitt's tumor or lymphoma 200.3 Marginal zone lymphoma 200.4 Mantle cell lymphoma 200.5 Primary central nervous system ... urinary organs 224 Benign neoplasm of eye 225 Benign neoplasm of brain and other parts of nervous system 226 Benign neoplasm of ... neoplasm of eye 191 Malignant neoplasm of brain 192 Malignant neoplasm of other and unspecified parts of nervous system 192.0 ... 140 Malignant neoplasm of lip 141 Malignant neoplasm of tongue 142 Malignant neoplasm of major salivary glands 143 Malignant ...
https://en.wikipedia.org/wiki/List_of_ICD-9_codes_140–239:_neoplasms
Blastic plasmacytoid dendritic cell neoplasmBlastic plasmacytoid dendritic cell neoplasm
... central nervous system, or other tissues. The neoplasm occurs in individuals of all ages but predominates in the elderly; in ... Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy. It was initially regarded as a form of ... Blastic plasmacytoid dendritic cell neoplasm is an aggressive malignancy with features of cutaneous lymphoma (e.g. malignant ... Blastic plasmacytoid dendritic cell neoplasm occurs in children, including neonates, but is more common in adults, particularly ...
https://en.wikipedia.org/wiki/Blastic_plasmacytoid_dendritic_cell_neoplasm
WHO classification of tumours of the central nervous systemWHO classification of tumours of the central nervous system
... neoplasms 8.1.1 Meningeal melanocytosis and meningeal melanomatosis 8.2 Circumscribed meningeal melanocytic neoplasms 8.2.1 ... Grading of the tumors of the central nervous system See the article Grading of the tumors of the central nervous system. Louis ... The following is a simplified (deprecated) version of the 2021 WHO classification of the tumours of the central nervous system ... 2016). WHO Classification of Tumours of the Central Nervous System (Revised 4th ed.). Lyon: International Agency for Research ...
https://en.wikipedia.org/wiki/WHO_classification_of_tumours_of_the_central_nervous_system
C72C72
... cranial nerves and other parts of central nervous system ICD-10 code Siemens C72, a mobile phone Honda C71, C76, C72, C77 Dream ... C72 may refer to : Ruy Lopez chess openings ECO code Malignant neoplasm of spinal cord, ...
https://en.wikipedia.org/wiki/C72
Malignant rhabdoid tumourMalignant rhabdoid tumour
Weeks and associates reported on 111 renal rhabdoid cases of which 13.5% also had a central nervous system malignancy. It has ... MRTs are a rare and highly malignant childhood neoplasm. Rhabdoid tumours outside the kidney were later reported in many ... PJ Biggs; Garen PD; Powers JM; Garvin AJ (1987). "Malignant rhabdoid tumor of the central nervous system". Human Pathology. 18 ... and the central nervous system. Several cases of primary intracranial MRT have been reported since its recognition as a ...
https://en.wikipedia.org/wiki/Malignant_rhabdoid_tumour
LymphomaLymphoma
... can also spread to the central nervous system, often around the brain in the meninges, known as lymphomatous ... Historically, mature histiocytic and dendritic cell (HDC) neoplasms have been considered mature lymphoid neoplasms, since these ... Post-transplant Associated with methotrexate therapy Primary central nervous system lymphoma occurs most often in ... Because the whole lymphatic system is part of the body's immune system, people with a weakened immune system such as from HIV ...
https://en.wikipedia.org/wiki/Lymphoma
Dendritic cellDendritic cell
... central nervous system, and other tissues. Typically, the disease presents with skin lesions (e.g. nodules, tumors, papules, ... Blastic plasmacytoid dendritic cell neoplasm is a rare type of myeloid cancer in which malignant pDCs infiltrate the skin, bone ... symptoms of central nervous system dysfunction, and similar abnormalities in breasts, eyes, kidneys, lungs, gastrointestinal ... For discovering the central role of dendritic cells in the adaptive immune response, Steinman was awarded the Albert Lasker ...
https://en.wikipedia.org/wiki/Dendritic_cell
Altered level of consciousnessAltered level of consciousness
Infections of the central nervous system may also be associated with decreased LOC; for example, an altered LOC is the most ... Neoplasms within the intracranial cavity can also affect consciousness, as can epilepsy and post-seizure states. A decreased ... Scheld WM, Whitley RJ, Marra CM (2004). Infections of the Central Nervous System. Hagerstown, MD: Lippincott Williams & Wilkins ... Central nervous system disorders, Symptoms and signs of mental disorders, Consciousness). ...
https://en.wikipedia.org/wiki/Altered_level_of_consciousness
List of MeSH codes (C10)List of MeSH codes (C10)
... hypothalamic neoplasms MeSH C10.551.240.250.700.500.500 - pituitary neoplasms MeSH C10.551.240.375 - central nervous system ... central nervous system MeSH C10.228.140.300.850.125 - aids arteritis, central nervous system MeSH C10.228.140.300.850.250 - ... central nervous system MeSH C10.500.190.600 - central nervous system venous angioma MeSH C10.500.190.800 - sinus pericranii ... central nervous system MeSH C10.114.875.350 - lupus vasculitis, central nervous system MeSH C10.114.875.700 - temporal ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C10)
Plasmacytoid dendritic cellPlasmacytoid dendritic cell
... central nervous system, and other tissues. Typically, the disease presents with skin lesions (e.g. nodules, tumors, papules, ... Wang S, Wang X, Liu M, Bai O (April 2018). "Blastic plasmacytoid dendritic cell neoplasm: update on therapy especially novel ... symptoms of central nervous system dysfunction, and similar abnormalities in breasts, eyes, kidneys, lungs, gastrointestinal ... Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare type of myeloid cancer in which malignant pDCs infiltrate the ...
https://en.wikipedia.org/wiki/Plasmacytoid_dendritic_cell
ThrombolysisThrombolysis
History of stroke, dementia, or central nervous system damage within 1 year Head trauma within 3 weeks or brain surgery within ... known intracranial arteriovenous malformation or previously known intracranial neoplasm Suspected recent (within 30 days) ... 6 months Known intracranial neoplasm Suspected aortic dissection Internal bleeding within 6 weeks Active bleeding or known ...
https://en.wikipedia.org/wiki/Thrombolysis
NeurocytomaNeurocytoma
... is a type of nervous system benign tumor which is primarily derived from nervous tissue. Central neurocytoma " ... Nervous system disease stubs, Neoplasm stubs). ...
https://en.wikipedia.org/wiki/Neurocytoma
MedulloblastomaMedulloblastoma
"Selected Primary Brain and Central Nervous System Tumor Age-Specific Incidence Rates" (PDF). Central Brain Tumor Registry of ... Intracranial Neoplasms and Paraneoplastic Disorders". In Ropper AH, Samuels MA (eds.). Adams and Victor's Principles of ... "Selected Childhood Primary Brain and Central Nervous System Tumor Age-Specific Incidence Rates" (PDF). Central Brain Tumor ... September 1998). "Atypical teratoid/rhabdoid tumor of the central nervous system: a highly malignant tumor of infancy and ...
https://en.wikipedia.org/wiki/Medulloblastoma
T-Cell Acute Lymphoblastic LeukemiaT-Cell Acute Lymphoblastic Leukemia
Its clinical presentation most commonly includes infiltration of the central nervous system (CNS), and further identifies ... T-Cell Lymphoblastic Leukemia (T-ALL) is a type of acute lymphoblastic leukemia with aggressive malignant neoplasm of the bone ... However, they have their own system of classifying T-ALL cases. First, patterns of gene expression are investigated to define T ... T-ALL is a precursor for lymphoid neoplasm. ...
https://en.wikipedia.org/wiki/T-Cell_Acute_Lymphoblastic_Leukemia
HeadacheHeadache
... headache evaluation may include CT scan or MRI in order to look for possible structural disorders of the central nervous system ... intracranial neoplasm, epileptic seizure or other types of disorders or diseases that are intracranial but that are not ... According to this system, there are 19 types of neuralgias and headaches due to different central causes of facial pain. ... associated with the vasculature of the central nervous system.[citation needed] ICHD-2 classifies headaches that are caused by ...
https://en.wikipedia.org/wiki/Headache
Brain tumorBrain tumor
The spinal cord is considered a part of the central nervous system. It is made up of the same cells as the brain: neurons and ... Brain Tumor Nervous system neoplasm List of brain tumor cases "Adult Brain Tumors Treatment". NCI. 28 February 2014. Archived ... Central nervous system tumors make up 20-25 percent of cancers in children. The average survival rate for all primary brain ... "Adult Central Nervous System Tumors Treatment (PDQ®)-Patient Version - National Cancer Institute". www.cancer.gov. 11 May 2020 ...
https://en.wikipedia.org/wiki/Brain_tumor
Medial longitudinal fasciculusMedial longitudinal fasciculus
Because multiple sclerosis causes demyelination of the axons of the central nervous system, it can cause internuclear ... Other demyelinating diseases, as well as certain neoplasms and strokes, can also cause the same symptoms. In 1846, neurologist ... doi:10.1016/B0-12-227210-2/00208-9. ISBN 978-0-12-227210-3. Watson, Charles (2012). "12 - Hindbrain". The Mouse Nervous System ... The medial longitudinal fasciculus is the main central connection for the oculomotor nerve, trochlear nerve, and abducens nerve ...
https://en.wikipedia.org/wiki/Medial_longitudinal_fasciculus
List of cancer typesList of cancer types
Nodal marginal zone B cell lymphoma Non-Hodgkin lymphoma Precursor B lymphoblastic leukemia Primary central nervous system ... Marginal zone B-cell lymphoma Mast cell leukemia Mediastinal large B cell lymphoma Multiple myeloma/plasma cell neoplasm ... and are intended to fully differentiate and mature into normal components of the immune system and the blood, respectively. ...
https://en.wikipedia.org/wiki/List_of_cancer_types
FibromaFibroma
The neurofibroma is a benign nerve-sheath tumor in the peripheral nervous system. It appears in the sex cord-stromal tumour ... The cystic fibroma (fibroma cysticum) has central softening or dilated lymphatic vessels. The myxofibroma (fibroma myxomatodes ... group of ovarian neoplasms. Ovary fibromas are most frequent during middle age, and rare in children. Upon gross pathological ...
https://en.wikipedia.org/wiki/Fibroma
Michael L. J. ApuzzoMichael L. J. Apuzzo
He studied functional restoration in the central nervous system and performed North America's first human stereotactic cerebral ... he developed early refinements of microsurgical techniques for the management of intracranial neoplasms. Specifically, he ... The biological restoration of central nervous system architecture and function: part 1-foundations and historical landmarks in ... Combined Modality Therapy of Central Nervous System Tumors. ISBN 9783540006275. Hoh DJ, Liu CY, Pagnini PG, Yu C, Wang MY, ...
https://en.wikipedia.org/wiki/Michael_L._J._Apuzzo
AstroblastomaAstroblastoma
The World Health Organization, a specialized agency that classifies abnormal tumors affecting the central nervous system and ... often mistaking astroblastoma with glial neoplasms, high-grade astrocytes, and embryonal neoplasms. However, the "bubbly" ... Calcification deriving from nervous system tumors is a rare quality in astroblastoma patients, but it is nonetheless easy to ... "Astroblastoma in a Child." Children Nervous System 24.2 (2008): 165-68. Sughrue, Michael E., Jay Choi, Martin Rutkowski, and ...
https://en.wikipedia.org/wiki/Astroblastoma
Papillary tumors of the pineal regionPapillary tumors of the pineal region
Papillary tumors of the central nervous system and particularly of the pineal region are very rare and so diagnosing them is ... The critical diagnosis of this neoplasm is often difficult because of its similarity with other primary or secondary papillary ... WHO classification of tumours of the central nervous system, chapter 7, Eds: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, IARC ... Papillary tumors of pineal region are extremely rare, constituting 0.4-1% of all central nervous system tumors. These tumors ...
https://en.wikipedia.org/wiki/Papillary_tumors_of_the_pineal_region
Tetratricopeptide repeat protein 39BTetratricopeptide repeat protein 39B
TTC39B is well expressed in muscles, internal organs, secretory organs, reproductive organs, the immune system, and the nervous ... Isoform 2 uses an alternate in-frame splice site in the central coding region, compared to variant 1, which results in a ... TTC39A has been tested for association to diseases like breast neoplasms and is expected to have molecular binding function and ... Isoform 3 and 4 have multiple differences in the central coding region but maintain the reading frame compared to isoform 1. ...
https://en.wikipedia.org/wiki/Tetratricopeptide_repeat_protein_39B
List of diseases (C)List of diseases (C)
Cennamo-Gangemi syndrome Central core disease Central diabetes insipidus Central nervous system protozoal infections Central ... Carrington syndrome Cartilage hair hypoplasia like syndrome Cartilage-hair hypoplasia Cartilaginous neoplasms Cartwright-Nelson ... serous chorioretinopathy Central type neurofibromatosis Centromeric instability immunodeficiency syndrome Centronuclear ... hypoxia Cerebral malformations hypertrichosis claw hands Cerebral palsy Cerebral thrombosis Cerebral ventricle neoplasms ...
https://en.wikipedia.org/wiki/List_of_diseases_(C)
Choroid plexus tumorChoroid plexus tumor
The 2007 WHO classification of tumours of the central nervous system, Acta Neuropathol. 114 (2) (2007) 97-109. I. Nakano, A. ... Choroid plexus tumors (CPTs) are uncommon CNS tumors that account for 0.5-0.6% of intracranial neoplasms in people of all ages ... The 2016 world health organization classification of tumours of the central nervous system: what the paediatric ... Pediatric choroid plexus neoplasms: MR, CT, and pathologic correlation, Radiology 173 (1) (1989) 81-88 A.W. McEvoy, B.N. ...
https://en.wikipedia.org/wiki/Choroid_plexus_tumor
Primary effusion lymphomaPrimary effusion lymphoma
Individuals with extracavitary PEL present with lesions in the lung, central nervous system, gastrointestinal tract, and/or ... This lymphoma also belongs to a group of lymphoid neoplasms with plasmablastic differentiation that involve malignant ... central nervous system, testes, paranasal sinuses, muscle, and, rarely, inside the vasculature and sinuses of lymph nodes. As ... central nervous system symptoms), or breast implants (e.g. breast swelling/pain/malformation). While most cases of classical ...
https://en.wikipedia.org/wiki/Primary_effusion_lymphoma
Virtual karyotypeVirtual karyotype
Tumors of the Nervous System, Wiley Blackwell 2009. Tumors of the Central Nervous System. Vol 7. Washington DC: American ... Renal epithelial neoplasms have characteristic cytogenetic aberrations that can aid in classification. See also Atlas of ... "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms." Nature 13 Aug 2009; 460, 904-909. Gondek LP, Tiu R, ... Malignant rhabdoid tumors are rare, highly aggressive neoplasms found most commonly in infants and young children. Due to their ...
https://en.wikipedia.org/wiki/Virtual_karyotype
NeprilysinNeprilysin
"Immunoreactivity of CD10 and inhibin alpha in differentiating hemangioblastoma of central nervous system from metastatic clear ... CD10+ differentiates mucinous cystic neoplasms (CD10+/CK20+) from intraductal papillary mucinous neoplasm of branch duct type ( ... Murali R, Delprado W (2005). "CD10 immunohistochemical staining in urothelial neoplasms". Am. J. Clin. Pathol. 124 (3): 371-9. ... CD10 expression might be one of the characteristics of müllerian system-derived neoplastic mesenchymal cells. Normal ...
https://en.wikipedia.org/wiki/Neprilysin
Intention tremorIntention tremor
The agonist buspirone hydrochloride, which decreases serotonin's function in the central nervous system, has been viewed as an ... Focal lesions such as neoplasms, tumors, hemorrhages, demyelination, or other damage may be causing dysfunction of the ... the major inhibitory neurotransmitter in the central nervous system. This causes a reduction in cerebellar ataxias. Another ... Nervous and musculoskeletal systems, Neurological disorders, Extrapyramidal and movement disorders). ...
https://en.wikipedia.org/wiki/Intention_tremor
Facial nerve paralysisFacial nerve paralysis
Bilateral facial nerve paralysis may occur in Guillain-Barré syndrome, an autoimmune condition of the peripheral nervous system ... Central facial palsy can be caused by a lacunar infarct affecting fibers in the internal capsule going to the nucleus. The ... Often, since facial neoplasms have such an intimate relationship with the facial nerve, removing tumors in this region becomes ... is a common manifestation of sarcoidosis of the nervous system, neurosarcoidosis. ...
https://en.wikipedia.org/wiki/Facial_nerve_paralysis
Adrenal medullaAdrenal medulla
... and preganglionic autonomic nerve fibers lead to them directly from the central nervous system. The adrenal medulla affects ... Neoplasms include: Pheochromocytoma (most common), a catecholamine-secreting tumor of the adrenal medulla Neuroblastoma, a ... As a cluster of neuron cell bodies, the adrenal medulla is considered a modified ganglion of the sympathetic nervous system. ... They are modified postganglionic sympathetic neurons of the autonomic nervous system that have lost their axons and dendrites, ...
https://en.wikipedia.org/wiki/Adrenal_medulla
SeminomaSeminoma
In the ovary, the tumor is called a dysgerminoma, and in non-gonadal sites, particularly the central nervous system, it is ... It is a malignant neoplasm and is one of the most treatable and curable cancers, with a survival rate above 95% if discovered ...
https://en.wikipedia.org/wiki/Seminoma
Radiation therapyRadiation therapy
... late effect neuropathy may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS). In the CNS ... Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ... This can be done automatically using an external monitoring system such as a spirometer or a camera and markers. The same ... 1) Knowledge based planning where the treatment planning system has a library of high quality plans, from which it can predict ...
https://en.wikipedia.org/wiki/Radiation_therapy
List of skin conditionsList of skin conditions
Neurocutaneous conditions are due organic nervous system disease or are psychiatric in etiology. Atypical chronic pain syndrome ... Bubble hair deformity Central centrifugal cicatricial alopecia (follicular degeneration syndrome, pseudopelade of the central ... neoplasms, and cysts are skin lesions that develop from the epidermal layer of the skin. Aberrant basal cell carcinoma ... Many skin conditions affect the human integumentary system-the organ system covering the entire surface of the body and ...
https://en.wikipedia.org/wiki/List_of_skin_conditions
Acute lymphoblastic leukemiaAcute lymphoblastic leukemia
... since systemic chemotherapy can have limited penetration into the central nervous system and the central nervous system is a ... May 2016). "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. ... Central nervous system (CNS) symptoms such as cranial neuropathies due to meningeal infiltration are identified in less than 10 ... Due to the presence of CNS involvement in 10-40% of adults with ALL at diagnosis, most providers start Central nervous system ( ...
https://en.wikipedia.org/wiki/Acute_lymphoblastic_leukemia
SOX10SOX10
Inoue K, Tanabe Y, Lupski JR (1999). "Myelin deficiencies in both the central and the peripheral nervous systems associated ... SOX10 is used as an immunohistochemistry marker, being positive in: Neuroectodermal neoplasms of neural crest origin, ... This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system ... Bondurand N, Sham MH (October 2013). "The role of SOX10 during enteric nervous system development". Dev. Biol. 382 (1): 330-43 ...
https://en.wikipedia.org/wiki/SOX10
Ollier diseaseOllier disease
... carries a higher risk of malignancies such as central nervous system (CNS), ovarian, and adenocarcinoma. Cranial ... While chondrosarcoma is the most common form of a secondary malignant bone neoplasm found in cases of Ollier disease, other ... Early detection and consistent and repeated monitoring is important in order to prevent and treat any potential bone neoplasms ... Clinical and radiological evaluations are conducted in order to detect the presence of bone neoplasms or lesions typically ...
https://en.wikipedia.org/wiki/Ollier_disease
Proton therapyProton therapy
"Proton Radiotherapy for Primary Central Nervous System Tumours in Adults (PRO-CNS)". ClinicalTrials.gov. August 2020. "Dose- ... Two prominent examples are pediatric neoplasms (such as medulloblastoma) and prostate cancer. Irreversible long-term side ... and brain/central nervous system. The study included a total of 450,373 patients and concluded that proton therapy was ... As of 2018, the cost of a single-room particle therapy system is US$40 million, with multi-room systems costing up to US$200 ...
https://en.wikipedia.org/wiki/Proton_therapy
Glossary of communication disordersGlossary of communication disorders
Neuroplasticity Ability of the brain and/or certain parts of the nervous system to adapt to new conditions, such as an injury. ... Laryngeal neoplasms Abnormal growths in the larynx (voice box) that can be cancerous or noncancerous. Laryngeal nodules ... Central auditory processing disorder Inability to differentiate, recognize, or understand sounds; hearing and intelligence are ... Neural prostheses Devices that substitute for an injured or diseased part of the nervous system, such as the cochlear implant. ...
https://en.wikipedia.org/wiki/Glossary_of_communication_disorders
Diffuse leptomeningeal glioneuronal tumorDiffuse leptomeningeal glioneuronal tumor
The 2016 World Health Organization classifcation of tumors of the central nervous system: a summary. Acta Neuropathol 131:803- ... Open 2015, 2, 2329048X14567531 Psarros TG, Swift D, Mulne AF et al (2005) Neurocytoma-like neoplasm of the thoracic spine in a ... 2016 Updates to the WHO Brain Tumor Classification System: What the Radiologist Needs to Know. Radiographics 2017, 37, 2164- ... and described as diffuse oligodendroglial-like leptomeningeal tumor of children in the 2016 classification of CNS neoplasms by ...
https://en.wikipedia.org/wiki/Diffuse_leptomeningeal_glioneuronal_tumor
Interventional radiologyInterventional radiology
... root is the initial or proximal segment of one of the thirty-one pairs of spinal nerves leaving the central nervous system from ... such as osteoporosis or underlying neoplasm. Analogous to vertebroplasty, the purpose of sacroplasty is to provide ... peripherally inserted central cathethers (or PICCs), tunneled small bore central venous catheters, and mediports. These lines ... There are several systems for staging PAD, but an often used scale is the revised Rutherford classification. Plaque and blood ...
https://en.wikipedia.org/wiki/Interventional_radiology
ActinomycesActinomyces
... species have also been shown to infect the central nervous system in a dog "without history or evidence of previous ... Another form of actinomycosis is thoracic disease, which is often misdiagnosed as a neoplasm, as it forms a mass that extends ...
https://en.wikipedia.org/wiki/Actinomyces
Effects of long-term benzodiazepine useEffects of long-term benzodiazepine use
Kellogg CK (1985). "Drugs and chemicals that act on the central nervous system: interpretation of experimental evidence". ... The cancers included cancer of the brain, lung, bowel, breast, and bladder, and other neoplasms. It has been hypothesised[by ... The prenatal toxicity of benzodiazepines is most likely due to their effects on neurotransmitter systems, cell membranes and ... The CT scan abnormalities showed dilatation of the ventricular system. However, unlike people who consume excessive alcohol, ...
https://en.wikipedia.org/wiki/Effects_of_long-term_benzodiazepine_use
List of MeSH codes (C04)List of MeSH codes (C04)
... central nervous system neoplasms MeSH C04.588.614.250.195 - brain neoplasms MeSH C04.588.614.250.195.205 - cerebral ventricle ... pituitary neoplasms MeSH C04.588.614.250.387 - central nervous system cysts MeSH C04.588.614.250.387.100 - arachnoid cysts MeSH ... peripheral nervous system neoplasms MeSH C04.588.614.596.240 - cranial nerve neoplasms MeSH C04.588.614.596.240.015 - neuroma, ... central nervous system MeSH C04.557.645.375.850 - sturge-weber syndrome MeSH C04.557.645.380 - hemangiopericytoma MeSH C04.557. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C04)
Burton DrayerBurton Drayer
MRI Contrast Enhancement in the Central Nervous System. A Case Approach. (Assoc. Eds., Drayer BP, Haughton VM, Jinkins JR, ... vascular malformation advanced CT and MRI techniques for the diagnosis of brain neoplasm. He is known for brain iron, ... As of 2020, he is the Charles M. and Marilyn Newman Professor and System Chair, Radiology, for The Mount Sinai Health System ... "Burton P Drayer MD". Mount Sinai Health System. Retrieved 20 May 2020. Mount Sinai Health System Profile Icahn School of ...
https://en.wikipedia.org/wiki/Burton_Drayer
Dipòsit Digital de la Universitat de Barcelona: Blastic plasmacytoid dendritic cell neoplasm frequently shows occult central...Dipòsit Digital de la Universitat de Barcelona: Blastic plasmacytoid dendritic cell neoplasm frequently shows occult central...
Blastic plasmacytoid dendritic cell neoplasm frequently shows occult central nervous system involvement at diagnosis and ... is a rare aggressive myeloid neoplasm which shows a high rate of central nervous system (CNS) recurrence and overall survival ( ...
http://diposit.ub.edu/dspace/handle/2445/178701?mode=full
Why Still in Neurosurgical Ward After Tumor Craniotomy? - Full Text View - ClinicalTrials.govWhy Still in Neurosurgical Ward After Tumor Craniotomy? - Full Text View - ClinicalTrials.gov
Central Nervous System Neoplasms. Nervous System Neoplasms. Neoplasms by Site. Neoplasms. Brain Diseases. Central Nervous ...
https://clinicaltrials.gov/show/NCT05288088
Emerging tumor entities and variants of CNS neoplasmsEmerging tumor entities and variants of CNS neoplasms
... classification for central nervous system (CNS) neoplasms, numerous descriptions of new entities or variants have appeared in ... In the group of neuronal and mixed glioneuronal neoplasms are lesions with distinctive mor … ... Since the appearance in 2000 of the World Health Organization (WHO) classification for central nervous system (CNS) neoplasms, ... Central Nervous System Neoplasms / classification* * Central Nervous System Neoplasms / pathology* * Ependymoma / ...
https://pubmed.ncbi.nlm.nih.gov/15055442/?dopt=Abstract
IMSEAR at SEARO: A study of incidence of neurogenic neoplasms in the central nervous system.
A study of incidence of neurogenic neoplasms in the central nervous system. Neurology India. 1973 Mar; 21(1): 32-6. ... A study of incidence of neurogenic neoplasms in the central nervous system. ...
https://imsear.searo.who.int/handle/123456789/121639
Results of search for 'ccl=su:{Central nervous system} and su-to:Neoplasms, Nerve tissue' › WHO HQ Library catalog
Central nervous system} and su-to:Neoplasms, Nerve tissue Refine your search. *. Availability. * Limit to currently available ... Histological typing of tumours of the central nervous system / P. Kleihues, P. C. Burger, and B. W. Scheithauer, in ... Types histologiques des tumeurs du système nerveux central / K. J. Zülch, avec la collaboration de pathologistes de 14 pays. by ...
https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=ccl=su%3A%7BCentral%20nervous%20system%7D%20and%20su-to%3ANeoplasms%2C%20Nerve%20tissue&sort_by=relevance_dsc&count=20&limit=location:BORROWABLE-COLL-STACKS
International variations in age-specific incidence rates of central nervous system (CNS) neoplasms in children and adolescents....International variations in age-specific incidence rates of central nervous system (CNS) neoplasms in children and adolescents....
International variations in age-specific incidence rates of central nervous system (CNS) neoplasms in children and adolescents ... International variations in age-specific incidence rates of central nervous system (CNS) n ... Neoplasias do Sistema Nervoso Central; Humanos; Adolescente; Criança; Incidência; Neoplasias do Sistema Nervoso Central/ ... Neoplasias do Sistema Nervoso Central Limite: Adolescente / Criança / Humanos Idioma: Inglês Revista: Jpn J Clin Oncol Ano de ...
https://pesquisa.bvsalud.org/controlecancer/resource/pt/mdl-36857590
Second malignant neoplasms after primary central nervous system malignancies of childhood and adolescence - Central...
Second malignant neoplasms after primary central nervous system malignancies of childhood and adolescence. In: Pediatric ... Second malignant neoplasms after primary central nervous system malignancies of childhood and adolescence. Pediatric Hematology ... Second malignant neoplasms after primary central nervous system malignancies of childhood and adolescence. / Devarahally, ... title = "Second malignant neoplasms after primary central nervous system malignancies of childhood and adolescence", ...
https://scholars.cmich.edu/en/publications/second-malignant-neoplasms-after-primary-central-nervous-system-m-3
Recurrent mutations of MYD88 and TBL1XR1 in primary central nervous system lymphomasRecurrent mutations of MYD88 and TBL1XR1 in primary central nervous system lymphomas
Central Nervous System Neoplasms* / genetics * Central Nervous System Neoplasms* / metabolism * Chromosomal Instability* ... Recurrent mutations of MYD88 and TBL1XR1 in primary central nervous system lymphomas Clin Cancer Res. 2012 Oct 1;18(19):5203-11 ... Purpose: Our objective was to identify the genetic changes involved in primary central nervous system lymphoma (PCNSL) ...
https://pubmed.ncbi.nlm.nih.gov/22837180/
Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas - Full Text View - ClinicalTrials...Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas - Full Text View - ClinicalTrials...
Nervous System Neoplasms. Central Nervous System Neoplasms. Neoplasms, Neuroepithelial. Neuroectodermal Tumors. Neoplasms, Germ ... Neoplasms. Neoplasms, Glandular and Epithelial. Neoplasms, Nerve Tissue. Neoplasms by Site. Nervous System Diseases. ... Brain and Central Nervous System Tumors Drug: Isotretinoin Drug: Procarbazine Hydrochloride Phase 3 ...
https://clinicaltrials.gov/ct2/show/NCT00003564
Vaccine Therapy in Treating Patients With Malignant Glioma - Full Text View - ClinicalTrials.govVaccine Therapy in Treating Patients With Malignant Glioma - Full Text View - ClinicalTrials.gov
Nervous System Neoplasms. Central Nervous System Neoplasms. Neoplasms, Neuroepithelial. Neuroectodermal Tumors. Neoplasms, Germ ... Neoplasms. Neoplasms, Glandular and Epithelial. Neoplasms, Nerve Tissue. Neoplasms by Site. Nervous System Diseases. ... Brain and Central Nervous System Tumors Biological: therapeutic autologous dendritic cells Phase 1 ... in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor ...
https://www.clinicaltrials.gov/ct2/show/NCT00068510
Seizure Assessment in the Emergency Department: Overview, Pathophysiology, EtiologySeizure Assessment in the Emergency Department: Overview, Pathophysiology, Etiology
History of central nervous system (CNS) pathology (stroke, neoplasms, recent surgery). * History of systemic neoplasms, ... Central nervous system (CNS) infections and anoxic injury are the leading causes of mortality associated with SE. ...
http://emedicine.medscape.com/article/1609294
NIOSHTIC-2 Search Results - Full View
Purpose: To compare ascertainment of central nervous system (CNS) neoplasms with the use of mortality and incidence data as ... Central Nervous System Neoplasms; Death Certificates; Methodology; Mortality ... Cancer; Cancer-rates; Central-nervous-system-disorders; Epidemiology; Statistical-analysis; Aircraft-engines; Aircraft-parts- ... A comparison of central nervous system cancer ascertainment using mortality and incidence data. ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=agricultur%2A+or+farm%2A&f1=%2A&Adv=0&terms=1&PageNo=291&RecNo=2903&View=f&
Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)
Categories: Central Nervous System Neoplasms Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
https://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Central+Nervous+System+Neoplasms&parentid=17840&catid=30367
Medical Science Monitor | Computed Tomographic Studies of Noncalcified Nodules Related to Neuroendocrine Lung Tumor Using...Medical Science Monitor | Computed Tomographic Studies of Noncalcified Nodules Related to Neuroendocrine Lung Tumor Using...
Disseminated Pancreatic Neuroendocrine Neoplasm (NEN) with an Uncommon Localisation in the Central Nervous System. A Case ... PACAP and VIP in the photoneuroendocrine system (PNES). Katalin Köves, Viktória Vereczki, [...] Mária Kausz, Orsolya Kántor, ... Rethinking the opiate system? Morphine and morphine-6-glucuronide as new endocrine and neuroendocrine mediators. Elise Glattard ...
https://medscimonit.com/abstract/related/idArt/908545
Brain Neoplasms | Harvard Catalyst Profiles | Harvard CatalystBrain Neoplasms | Harvard Catalyst Profiles | Harvard Catalyst
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, ... Nervous System Neoplasms [C04.588.614]. *Central Nervous System Neoplasms [C04.588.614.250]. *Brain Neoplasms [C04.588.614.250. ... Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of ... "Brain Neoplasms" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ...
https://connects.catalyst.harvard.edu/Profiles/display/Concept/Brain%20Neoplasms
Antineoplaston Therapy in Treating Patients With Brain Stem GliomaAntineoplaston Therapy in Treating Patients With Brain Stem Glioma
Nervous System Neoplasms. *Central Nervous System Neoplasms. .map{width:100%;height:300px;margin-bottom:15px;} Name. Location. ...
http://www.knowcancer.com/cancer-trials/NCT00003459/
Genetics of Rubinstein-Taybi Syndrome: Practice Essentials, Pathophysiology, EpidemiologyGenetics of Rubinstein-Taybi Syndrome: Practice Essentials, Pathophysiology, Epidemiology
Tumor surveillance (central nervous system neoplasms and rhabdomyosarcoma) is important as well. ...
https://emedicine.medscape.com/article/948453-overview
Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)
Categories: Central Nervous System Neoplasms Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
https://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Central%20Nervous%20System%20Neoplasms&parentid=17840&catid=30367
Tardive Dyskinesia: Overview, Pathophysiology, EtiologyTardive Dyskinesia: Overview, Pathophysiology, Etiology
... or a central nervous system (CNS) neoplasm. The presence of hemiparesis, asymmetric reflexes, and other focal deficits ... the striatopallidonigral system, and other structures of the central nervous system that contribute to the regulation of ... have been categorized as EPSs caused by lesions of the extrapyramidal system of the central nervous system (CNS). ... Hypothesized pathways among basal ganglia and other structures of the central nervous system ...
https://emedicine.medscape.com/article/1151826-overview
Morphological central nervous system abnormality - Ontology Report - Rat Genome DatabaseMorphological central nervous system abnormality - Ontology Report - Rat Genome Database
A structural abnormality of the central nervous system.. Synonyms:. exact_synonym: Abnormality of the central nervous system; ... Morphological abnormality of the CNS; Morphological abnormality of the central nervous system. ... Abnormality of the nervous system. 0. Abnormal nervous system morphology. 0. Morphological central nervous system abnormality. ... Central nervous system axonal spheroid. 0. Central nervous system cyst +. 0. Morphological abnormality of the pyramidal tract + ...
https://rgd.mcw.edu/rgdweb/ontology/annot.html?acc_id=HP:0002011&species=Bonobo
Pathology for the Physical Therapist Assistant - 9780323395496Pathology for the Physical Therapist Assistant - 9780323395496
4. The Gastrointestinal System 5. The Renal and Urologic Systems. 6. Central Nervous System Neoplasms 7. Epilepsy. 8. Headache ... Introduction to Central Nervous System Disorders 19. Infectious Disorders of the Central Nervous System. 20. Degenerative ... 7. The Integumentary System. 8. The Endocrine and Metabolic Systems 9. The Cardiovascular System 10. The Hematologic System 11 ... Musculoskeletal Neoplasms. 17. Bone, Joint, and Soft Tissue Diseases and Disorders Section 4: Pathology of the Nervous System. ...
https://www.us.elsevierhealth.com/pathology-for-the-physical-therapist-assistant-9780323395496.html
What Residents Know About MSWhat Residents Know About MS
A new study shows that first-year neurology residents sometimes mistake multiple sclerosis for trauma or neoplasm. ... On the other hand, they mistakenly diagnosed cases of central nervous system infection, medical illness, trauma, and neoplasm ... such as neoplasm, neuropathy, or psychiatric illness. ...
http://www.medscape.com/viewarticle/845867
Multiple Cause Mortality 2002: List of 113 Selected Causes of DeathMultiple Cause Mortality 2002: List of 113 Selected Causes of Death
CDC WONDER is a system for disseminating Public Health data and information ... CDC WONDER is a system for disseminating Public Health data and information ... 035 Malignant neoplasm of bladder (C67) 036 Malignant neoplasms of meninges, brain and other parts of central nervous system( ... 044 In situ neoplasms, benign neoplasms and neoplasms of uncertain or unknown behavior(D00‑D48) ...
https://wonder.cdc.gov/wonder/sci_data/mort/mcmort/type_txt/mcmort02/113cause.asp
Welcome to PhenoDisWelcome to PhenoDis
Lipomas of the central neryous system. 1 / 7739 26. (HPO:0100006) Neoplasm of the central nervous system. Occasional [Orphanet ... Central nervous system anomalies consist of intracranial and intraspinal lipomas, congenital abnormalities of the meninges, and ... 2011) described 3 unrelated boys with ECCL with typical dermal, ocular, and central nervous system anomalies. One patient also ... Neoplasm of the skeletal system. Frequent [Orphanet] 30 / 7739 42. (HPO:0002652) Skeletal dysplasia. Occasional [Orphanet] 113 ...
http://mips.helmholtz-muenchen.de/phenodis/disease/show/2678
Pathology for the Physical Therapist Assistant - Elsevier eBook on VitalSource, 2nd Edition - 9780323395472Pathology for the Physical Therapist Assistant - Elsevier eBook on VitalSource, 2nd Edition - 9780323395472
The Gastrointestinal System 5. The Renal and Urologic Systems 6. Central Nervous System Neoplasms 7. Epilepsy 8. Headache 9. ... Introduction to Central Nervous System Disorders 19. Infectious Disorders of the Central Nervous System 20. Degenerative ... Musculoskeletal Neoplasms 17. Bone, Joint, and Soft Tissue Diseases and Disorders Section 4: Pathology of the Nervous System 18 ... The Integumentary System 8. The Endocrine and Metabolic Systems 9. The Cardiovascular System 10. The Hematologic System 11. The ...
https://evolve.elsevier.com/cs/product/9780323395472?role=student
Infant birthweight and risk of childhood cancer: International population-based case control studies of 40 000 cases<...Infant birthweight and risk of childhood cancer: International population-based case control studies of 40 000 cases<...
Central Nervous System Neoplasms Medicine & Life Sciences 14% * Birth Order Medicine & Life Sciences 13% ... Risk was strongest for leukaemia [USA: 1.10 (1.06, 1.13), UK: 1.07 (1.04, 1.10)], tumours of the central nervous system [USA: ... Risk was strongest for leukaemia [USA: 1.10 (1.06, 1.13), UK: 1.07 (1.04, 1.10)], tumours of the central nervous system [USA: ... Risk was strongest for leukaemia [USA: 1.10 (1.06, 1.13), UK: 1.07 (1.04, 1.10)], tumours of the central nervous system [USA: ...
https://experts.umn.edu/en/publications/infant-birthweight-and-risk-of-childhood-cancer-international-pop
Combined systemic and intraventricular chemotherapy in primary CNS lymphoma: a pilot study | Journal of Neurology, Neurosurgery...Combined systemic and intraventricular chemotherapy in primary CNS lymphoma: a pilot study | Journal of Neurology, Neurosurgery...
... a less toxic regimen for intraventricular chemotherapy of central nervous system neoplasms. Blood 51:835-842. ... 1996) Primary central nervous system lymphoma: curable without toxicity? Cancer Journal from Scientific American 2:137-139. ... 1999) Intravenous methotrexate as initial treatment for primary central nervous system lymphoma: response to therapy and ... Cognitive outcomes and long-term follow-up results after enhanced chemotherapy delivery for primary central nervous system ...
https://jnnp.bmj.com/content/71/1/118
KEGG DISEASE: Gastric cancerKEGG DISEASE: Gastric cancer
02 Neoplasms. Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related ... central nervous system or related tissues. Malignant neoplasms of digestive organs. 2B72 Malignant neoplasms of stomach. H00018 ... Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, ... Cancers of the digestive system. H00018 Gastric cancer. Human diseases in ICD-11 classification [BR:br08403]. ...
https://www.kegg.jp/entry/H00018
TumorsMetastasisMalignant NeoplasmIncidenceCancersBenignBrainMetastaticGliomaDisordersCancerTumours of the central nervouDiseasesPeripheralMeSHMyeloidMorphological featuresSistema nervioso centralDiagnosisMorbidityIntracranialPyramidalRespiratory systemKidneyPrimary central nervouHospitalNeurofibromatosisTissueChronicChildhood centralTissuesMethodologyRadiationVariants
Tumors10
  • These tumors are the principle CNS neoplasm of neurofibromatosis type 1 (NF1) . (medscape.com)
  • Primary germ cell tumors may arise aberrantly may arise in the central nervous system (CNS) which are mostly similar to germinal tumors of genital organs. (surgicalneurologyint.com)
  • Both tumors had second copy inactivation of NF2 , confirming the central role of the gene in meningioma formation. (biomedcentral.com)
  • There are some data that insulin, IGFBP-3, folic acid and 25-OH-D may influence the development of these tumors.Aim: To study the influence of insulin, IGFBP-3, folic acid and 25-OH-D, CA 19-9, CA 72-4 in the development of tumors of the gastrointestinal tract, and the frequency of neoplasms detection.Materials and Methods. (endocrine-abstracts.org)
  • Medulloblastoma is the most common malignant embryonic tumors of the central nervous system. (utmb.edu)
  • Methods and Materials: This retrospective study examined 1697 pediatric patients with central nervous system tumors who received treatment at Taipei Veterans General Hospital from January 1, 1975, to December 31, 2013. (elsevier.com)
  • We examined the incidence of first primary central nervous system tumors (PCNST) in California from 2001-2005. (cdc.gov)
  • Central nervous system (CNS) cancers are neoplasms of the neuroepithelial tissue and membranous coverings of the brain and spinal cord, tumors of the pituitary gland, and cancers arising from the cranial nerves and CNS hematopoietic cells. (cdc.gov)
  • The most common malignant neoplasms of childhood are the leukemias, central nervous system tumors, and the lymphomas 2 . (bvsalud.org)
  • This benign clinical course underscores the importance of accurately distin- guishing these tumors from other glial neoplasms. (vdocuments.mx)
Metastasis1
  • Engelhard HH, Corsten LA. Leptomeningeal metastasis of primary central nervous system (CNS) neoplasms. (medscape.com)
Malignant Neoplasm1
  • To describe the prevalence of inadequate nutritional status of children and adolescents with malignant neoplasm at hospital admission in childhood cancer reference centers in Brazil. (bvsalud.org)
Incidence7
  • IMSEAR at SEARO: A study of incidence of neurogenic neoplasms in the central nervous system. (who.int)
  • International variations in age-specific incidence rates of central nervous system (CNS) neoplasms in children and adolescents. (bvsalud.org)
  • The standardized incidence ratios (SIR) and cumulative incidence rates were determined for developing second malignant neoplasms (SMNs) after primary central nervous system (CNS) malignancies occurring during childhood using registry data. (cmich.edu)
  • A comparison of central nervous system cancer ascertainment using mortality and incidence data. (cdc.gov)
  • Purpose: To compare ascertainment of central nervous system (CNS) neoplasms with the use of mortality and incidence data as part of an occupational epidemiology study. (cdc.gov)
  • Main outcome measures Incidence of cancers of the brain and central nervous system, leukaemia, and non-Hodgkin's lymphomas, and all cancers combined, adjusted for small area measures of education level, socioeconomic deprivation, population density, and population mixing. (bmj.com)
  • Methods: We used the database of the International Incidence of Childhood Cancer study (IICC-3) to analyse global variations in neuroblastoma and peripheral nervous tumours incidence. (who.int)
Cancers2
  • Elevated SMRs were noted for cancers of the stomach, rectum, brain and other central nervous system sites, connective and other soft tissue, as well as for unspecified neoplasms of the nervous system and unspecified anemias. (cdc.gov)
  • Central nervous system tumours (CNS) represent 20% of childhood cancers. (who.int)
Benign1
  • Primary neoplasms are subdivided into benign and malignant forms. (harvard.edu)
Brain9
  • Brain Neoplasms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. (harvard.edu)
  • This graph shows the total number of publications written about "Brain Neoplasms" by people in Harvard Catalyst Profiles by year, and whether "Brain Neoplasms" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Brain Neoplasms" by people in Profiles. (harvard.edu)
  • Primary central nervous system lymphoma: Phase I evaluation of infusional bromodeoxyuridine with whole brain accelerated fractionation radiation therapy after chemotherapy. (jefferson.edu)
  • Primary central nervous system (CNS) lymphoma is a cancerous (malignant) tumor affecting white blood cells (lymphocytes) in the brain or spinal cord. (kembrel.com)
  • Purpose: This guideline provides updated evidence-based recommendations addressing recent developments in the management of patients with brain metastases, including advanced radiation therapy techniques such as stereotactic radiosurgery (SRS) and hippocampal avoidance whole brain radiation therapy and the emergence of systemic therapies with central nervous system activity. (elsevier.com)
  • For patients with asymptomatic brain metastases eligible for central nervous system-active systemic therapy, multidisciplinary and patient-centered decision-making to determine whether local therapy may be safely deferred is conditionally recommended. (elsevier.com)
  • Brain cells, or neurons, are the building blocks of the nervous system. (giantmicrobes.com)
Metastatic1
  • Metastatic supratentorial neoplasms are frequently multiple at the time of presentation. (rush.edu)
Glioma1
  • 1990a, 1990b, 1995) reportaron un aumento de la proliferación celular en experimentos realizados utilizando células de un glioma cerebral, linfocitos humanos y células ováricas de Hámster. (rfcom.ca)
Disorders4
  • For most of the past century, movement disorders (ie, abnormal adventitious movements) have been categorized as EPSs caused by lesions of the extrapyramidal system of the central nervous system (CNS). (medscape.com)
  • On April 23 and 24, 2019 the Forum on Neuroscience and Nervous System Disorders convened a workshop titled "Advancing Gene-Targeted Therapies for Central Nervous System Disorders" in Washington, DC. (amoscassidyauthor.com)
  • This public workshop brought together experts and key stakeholders from academia, government, industry, philanthropic foundations, and disease/patient-focused nonprofit organizations to explore approaches for advancing the development of gene-targeted therapies for central nervous system (CNS) disorders, and implications of developing these therapies. (amoscassidyauthor.com)
  • It is also used in the symptomatic treatment of inflammatory and allergic disorders and to suppress the immune system. (firedrug.com)
Cancer3
  • This book gives a comprehensive overview of the present status and future directions of gene delivery systems and therapeutic strategies for the clinical application of gene therapy in cancer, cardiovascular and central nervous system diseases. (amoscassidyauthor.com)
  • Within the Cancer Risk in Childhood Cancer Survivors (CRICCS) study we aimed to assess the ability of registries to collect data needed to conduct comparative studies of childhood cancer prevalence and risk of second primary neoplasms. (who.int)
  • These medications act by suppressing the immune system, leaving the patient exposed to severe infection and at risk of cancer. (hrb.ie)
Tumours of the central nervou2
  • Histological typing of tumours of the central nervous system / P. Kleihues, P. C. Burger, and B. W. Scheithauer, in collaboration with L. H. Sobin and pathologists in 14 countries. (who.int)
  • WHO Classification of Tumours of the Central Nervous System is the Revised 4th Edition of the WHO series on histological and genetic typing of human tumours. (who.int)
Diseases1
  • certain localized infections - see body system-related chapters infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium [except obstetrical tetanus] (O98. (who.int)
Peripheral3
  • Germ cell tumor are similar histologically to germ cells of genital organs and may arise rarely from central and peripheral nervous system. (surgicalneurologyint.com)
  • Central nervous system prophylaxis in peripheral T-cell lymphoma. (jefferson.edu)
  • These include rare reports of pancytopenia, aplastic anaemia, central and peripheral demyelinating events and reports of lupus, lupus-related conditions and Stevens-Johnson syndrome. (ecco-ibd.eu)
MeSH1
  • Methods: MEDLINE search was performed for original CT on "Central Nervous System Neoplasms"[Mesh]. (vumc.nl)
Myeloid1
  • These neoplasms can manifest with a myeloid, erythroid, or platelet precursor phenotype, or a combination thereof 5 . (bvsalud.org)
Morphological features2
  • In the group of neuronal and mixed glioneuronal neoplasms are lesions with distinctive morphological features that are still not included in a precise classification, including extraventricular neurocytoma, papillary glioneuronal tumor, rosette-forming glioneuronal of the fourth ventricle, glioneuronal with neuropil-like rosette, and DNT-like tumor of the septum pellucidum. (nih.gov)
  • Astrocytomas comprise a wide range of neoplasms that differ in their extent of invasiveness, morphological features, tendency for progression, and clinical course. (medscape.com)
Sistema nervioso central2
  • Objetivo general: generar recomendaciones basadas en la mejor evidencia disponible acerca del manejo de personas con tumores primarios del sistema nervioso central o que hayan sido tratados por ello. (bvsalud.org)
  • Objetivos específicos: personas con tumores primarios del sistema nervioso central o que hayan sido trat. (bvsalud.org)
Diagnosis1
  • To code a diagnosis of this type, you must use one of the seven child codes of P11 that describes the diagnosis 'other birth injuries to central nervous system' in more detail. (icd.codes)
Morbidity1
  • Primary central nervous system (CNS) lymphoma is a rare and aggressive CNS neoplasm with a high morbidity and often fatal outcome. (kembrel.com)
Intracranial2
  • There have been many reviews of central nervous system complications in MM but there are none on intracranial and leptomeningeal infiltration of MM. We review this here along with our clinicopathological experience and a summary of our present knowledge of this condition. (who.int)
  • There have been many reviews of the central nervous system (CNS) complications in MM but there are none on intracranial and leptomeningeal infiltration of MM. This review focuses on the infiltrative complications and intracranial plasmacytomas with no further discussion of the other possible CNS complications. (who.int)
Pyramidal3
  • The pyramidal system, controlling voluntary movements, includes precise anatomic pathways from the cortex to muscle. (medscape.com)
  • Voluntary movements through the pyramidal systems are visible. (medscape.com)
  • An example of a classic disorder of the pyramidal system is a stroke, resulting in paralysis of an extremity. (medscape.com)
Respiratory system2
  • Lecture and discussion sessions presenting intermediate concepts of radiation therapy treatment principles and practices for neoplasms of the skin, central nervous system, genitourinary system, gynecologic system, gastrointestinal system and respiratory system. (gvsu.edu)
  • The respiratory system is both a target organ and a portal of entry for toxicants. (cdc.gov)
Kidney2
  • The team's sights are set on rhabdomyosarcoma (a type of soft tissue sarcoma), neuroblastoma (the most common sympathetic nervous system tumour), kidney tumours (in particular Wilms tumour), and central nervous system neoplasms (in particular medulloblastoma). (singhealth.com.sg)
  • Malignant neoplasms of the kidney can originate from different types of tissue. (krebsdaten.de)
Primary central nervou2
  • Our objective was to identify the genetic changes involved in primary central nervous system lymphoma (PCNSL) oncogenesis and evaluate their clinical relevance. (nih.gov)
  • ATRT is a primary central nervous system (CNS) tumor. (cancer.gov)
Hospital3
  • The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff. (jefferson.edu)
  • This has a considerable impact on their physical and mental capacities.This study aimed to evaluate the quality of life of the elderly at the Yaoundé Central Hospital. (bvsalud.org)
  • Methods.We carried out a cross-sectional study of elderly patients who consulted at the Yaounde Central Hospital forfive months. (bvsalud.org)
Neurofibromatosis2
  • Neurofibromatosis type 2 (NF2) is a rare autosomal dominant nervous system tumor predisposition disorder caused by constitutive inactivation of one of the two copies of NF2 . (biomedcentral.com)
  • Neurofibromatosis type 2 (NF2) is an autosomal dominant tumor syndrome characterized by the growth of multiple neoplasms within the central nervous system. (biomedcentral.com)
Tissue1
  • Mathias Jakob Schleiden and Theodor Schwann proposed the theory that the nervous system should theoretically be composed of cells like all other organic tissue. (giantmicrobes.com)
Chronic1
  • Acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. (medicineshoppe.com)
Childhood central1
  • BACKGROUND: Paternal occupational exposures have been proposed as a risk factor for childhood central nervous system (CNS) tumours. (ox.ac.uk)
Tissues1
  • The Eunice Kennedy Shriver National Institute of Child Health and Human Development seeks research co-development partners and/or licensees to further develop and commercialize its methods of noninvasively and directly determining the absolute homeostatic state, metabolic activity, function, and viability of isolated cells, or tissues (ex vivo or in vivo), such as the Central Nervous System (CNS). (cancer.gov)
Methodology1
  • Recommendations were created using a predefined consensus-building methodology and system for grading evidence quality and recommendation strength. (elsevier.com)
Radiation1
  • The SIRs of developing second malignant neoplasms were 6.3 and 3.1 for those cases receiving and not receiving radiation therapy, respectively. (cmich.edu)
Variants1
  • Since the appearance in 2000 of the World Health Organization (WHO) classification for central nervous system (CNS) neoplasms, numerous descriptions of new entities or variants have appeared in the literature. (nih.gov)
Why Still in Neurosurgical Ward After Tumor Craniotomy? - Full Text View - ClinicalTrials.gov
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Seizure Assessment in the Emergency Department: Overview, Pathophysiology, Etiology
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Current Trends Prevalence of Self-Reported Epilepsy -- United States, 1986-1990
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Tardive Dyskinesia: Overview, Pathophysiology, Etiology
Tardive Dyskinesia: Overview, Pathophysiology, Etiology (emedicine.medscape.com)
Pediatric Ependymoma: Practice Essentials, Pathophysiology, Etiology
Pediatric Ependymoma: Practice Essentials, Pathophysiology, Etiology (emedicine.medscape.com)
What Residents Know About MS
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Pathology for the Physical Therapist Assistant - Elsevier eBook on VitalSource, 2nd Edition - 9780323395472
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(emedicine.medscape.com)
Pathology of Choroid Plexus Neoplasms: Overview, Etiology, Clinical Features
Pathology of Choroid Plexus Neoplasms: Overview, Etiology, Clinical Features (emedicine.medscape.com)
Geographic Variation in Pediatric Cancer Incidence - United States, 2003-2014 | MMWR
Geographic Variation in Pediatric Cancer Incidence - United States, 2003-2014 | MMWR (cdc.gov)
Pediatric Astrocytoma: Practice Essentials, Background, Pathophysiology
Pediatric Astrocytoma: Practice Essentials, Background, Pathophysiology (reference.medscape.com)
Pathology of Diffuse Astrocytomas: Definition and Overview, Pathophysiology, Epidemiology
Pathology of Diffuse Astrocytomas: Definition and Overview, Pathophysiology, Epidemiology (reference.medscape.com)
First insight into the somatic mutation burden of neurofibromatosis type 2-associated grade I and grade II meningiomas: a case...
First insight into the somatic mutation burden of neurofibromatosis type 2-associated grade I and grade II meningiomas: a case... (bmccancer.biomedcentral.com)
Endocrine tumours and neoplasia | 0041 | ECE2016 | 18th European Congress of Endocrinology | Endocrine Abstracts
Endocrine tumours and neoplasia | 0041 | ECE2016 | 18th European Congress of Endocrinology | Endocrine Abstracts (endocrine-abstracts.org)
Jia-Wei Lin - 研究成果 - 臺北醫學大學
Jia-Wei Lin - 研究成果 - 臺北醫學大學 (tmu.pure.elsevier.com)
PI3 kinase pathway regulated miRNome in glioblastoma: identification of miR-326 as a tumour suppressor miRNA | Molecular Cancer...
PI3 kinase pathway regulated miRNome in glioblastoma: identification of miR-326 as a tumour suppressor miRNA | Molecular Cancer... (molecular-cancer.biomedcentral.com)
Intrathecal Depot Cytarabine Therapy: A Welcome Addition to a Limited Armamentarium | Clinical Cancer Research | American...
Intrathecal Depot Cytarabine Therapy: A Welcome Addition to a Limited Armamentarium | Clinical Cancer Research | American... (aacrjournals.org)
Identification of PATCHED mutations in medulloblastomas by direct sequencing<...
Identification of PATCHED mutations in medulloblastomas by direct sequencing<... (researchexperts.utmb.edu)
Mobile phone base stations and early childhood cancers: case-control study | The BMJ
Mobile phone base stations and early childhood cancers: case-control study | The BMJ (bmj.com)
Astrocytoma Medication: Anticonvulsants, Corticosteroids, Antineoplastic Agent, Alkylating Agent
Astrocytoma Medication: Anticonvulsants, Corticosteroids, Antineoplastic Agent, Alkylating Agent (medscape.com)
Astrocytoma Workup: Laboratory Studies, Imaging Studies, Other Tests
Astrocytoma Workup: Laboratory Studies, Imaging Studies, Other Tests (emedicine.medscape.com)
Astrocytoma: Practice Essentials, Background, Pathophysiology
Astrocytoma: Practice Essentials, Background, Pathophysiology (emedicine.medscape.com)
Secondary CNS Melanomas: Overview, Pathophysiology, Clinical Assessment
Secondary CNS Melanomas: Overview, Pathophysiology, Clinical Assessment (emedicine.medscape.com)
Brain Neoplasms Clinical Presentation: History, Physical
Brain Neoplasms Clinical Presentation: History, Physical (emedicine.medscape.com)
(emedicine.medscape.com)
Brain Neoplasms Clinical Presentation: History, Physical
Brain Neoplasms Clinical Presentation: History, Physical (emedicine.medscape.com)