Central Nervous System Diseases
Central Nervous System Viral Diseases
Meningoencephalitis
Central Nervous System Infections
Nervous System Diseases
Central Nervous System
Subacute Sclerosing Panencephalitis
Brain
Brain Diseases
Maus Elberfeld virus
Meninges
Cerebrospinal Fluid
AIDS Dementia Complex
Demyelinating Diseases
Astrocytes
Magnetic Resonance Imaging
Disease Models, Animal
Neurons
Central Nervous System Neoplasms
Nervous System
Autonomic Nervous System Diseases
Cells, Cultured
Lamin Type A
Peripheral Nervous System
Digestive System Diseases
Peripheral Nervous System Diseases
Vasculitis, Central Nervous System
Neurologic complications of systemic cancer. (1/1158)
Neurologic complications occur frequently in patients with cancer. After routine chemotherapy, these complications are the most common reason for hospitalization of these patients. Brain metastases are the most prevalent complication, affecting 20 to 40 percent of cancer patients and typically presenting as headache, altered mental status or focal weakness. Other common metastatic complications are epidural spinal cord compression and leptomeningeal metastases. Cord compression can be a medical emergency, and the rapid institution of high-dose corticosteroid therapy, radiation therapy or surgical decompression is often necessary to preserve neurologic function. Leptomeningeal metastases should be suspected when a patient presents with neurologic dysfunction in more than one site. Metabolic encephalopathy is the common nonmetastatic cause of altered mental status in cancer patients. Cerebrovascular complications such as stroke or hemorrhage can occur in a variety of tumor-related conditions, including direct invasion, coagulation disorders, chemotherapy side effects and nonbacterial thrombotic endocarditis. Radiation therapy is the most commonly employed palliative measure for metastases. Chemotherapy or surgical removal of tumors is used in selected patients. (+info)Loss of 123I-MIBG uptake by the heart in Parkinson's disease: assessment of cardiac sympathetic denervation and diagnostic value. (2/1158)
Myocardial imaging with 123I-metaiodobenzylguanidine (MIBG) was performed on 35 patients with Parkinson's disease and 24 control subjects to evaluate cardiac sympathetic function in patients with Parkinson's disease, verify this phenomenon and examine whether myocardial MIBG uptake and clearance are correlated with the clinical severity of Parkinson's disease. METHODS: We studied 35 patients with Parkinson's disease and 24 control subjects with other central nervous system diseases. The latter group consisted of 12 subjects with other neurodegenerative disorders (4 with spinocerebellar degeneration, 2 with amyotrophic lateral sclerosis, 3 with progressive supranuclear palsy and 3 with corticobasal degeneration and 12 patients with cerebral infarction (CI), 6 with vascular parkinsonism and 6 without it. Early and delayed images of the anterior view were obtained 15 min and 4 h after injection of 123I-MIBG, respectively. MIBG uptake was quantified by calculating a heart-to-mediastinum count (H/M) ratio. RESULTS: The H/M ratio was markedly reduced in the patients with Parkinson's disease (II to V on the Hoehn and Yahr scale) compared with the control subjects. None of the subjects with neurodegenerative diseases showed a marked decrease in myocardial MIBG uptake nor did any subject with CI. CONCLUSION: Our findings indicate that, in Parkinson's disease, a reduction in myocardial MIBG uptake is a very common, specific phenomenon that can be used to detect cardiac autonomic dysfunction to diagnose Parkinson's disease, particularly in patients without typical signs and symptoms. (+info)A five-year assessment of controlled trials of in-patient and out-patient treatment and of plaster-of-Paris jackets for tuberculosis of the spine in children on standard chemotherapy. Studies in Masan and Pusan, Korea. Fifth report of the Medical Research Council Working Party on tuberculosis of the spine. (3/1158)
In two centres in Korea 350 patients with a diagnosis of tuberculosis of the thoracic and/or lumbar spine were allocated at random: in Masan to in-patient rest in bed (IP) for six months followed by out-patient treatment or to ambulatory out-patient treatment (OP) from the start; in Pusan to out-patient treatment with a plaster-of-Paris jacket (J) for nine months or to ambulatory treatment without any support (No J). All patients recieved chemotherapy with PAS with isoniazid for eighteen months, either supplemented with streptomycin for the first three months (SPH) or without this supplement (PH), by random allocation. The main analysis of this report concerns 299 patients (eighty-three IP, eighty-three OP, sixty-three J, seventy No J; 143 SPH, 156 PH). Pre-treatment factors were similar in both centres except that the patients in Pusan had, on average, less extensive lesions although in a greater proportion the disease was radiographically active. One patient (J/SPH) died with active spinal disease and three (all No J/SPH) with paraplegia. A fifth patient (IP/PH) who died from cardio respiratory failure also had pulmonary tuberculosis. Twenty-three patients required operation and/or additional chemotherapy for the spinal lesion. A sinus or clinically evident abscess was either present initially or developed during treatment in 41 per cent of patients. Residual lesions persisted in ten patients (four IP, two OP, one J, three No J; six SPH, four PH) at five years. Thirty-two patients had paraparesis on admission or developing later. Complete resolution occurred in twenty on the allocated regimen and in eight after operation or additional chemotherapy or both. Of the remaining four atients, all of whom had operation and additional chemotherapy, three died and one still had paraparesis at five years. Of 295 patients assessed at five years 89 per cent had a favourable status. The proportions of the patients responding favourably were similar in the IP (91 per cent) and OP (89 per cent) series, in the J (90 per cent) and No J (84 per cent) series and in the SPH (86 per cent) and PH (92 per cent) series. (+info)Fatal outcome due to cyclosporine neurotoxicity with associated pathological findings. (4/1158)
We present a case of death likely to be directly due to cyclosporine (CsA) neurotoxicity. To date, there have been no reports of deaths directly due to CsA neurotoxicity, nor has an associated histological lesion been described independent of confounding processes. A 54-year-old male received an HLA-matched-unrelated BMT for CML. He developed progressive encephalopathy and on day +79 had a generalized seizure. All CSF studies were negative for infectious causes. MRI revealed diffuse, symmetrical white matter abnormalities located in the occipital sub-cortex, thalamus, mid brain, pons, and cerebellum which were typical of CsA toxicity. The patient died of central respiratory failure within 72 h of discontinuing CsA. Autopsy revealed diffuse patchy white matter edema and astrocytic injury without evidence of axonopathy, demyelination, microvascular injury, or infectious/inflammatory process. This case demonstrates previously undescribed lethal CsA neurotoxicity and may reveal an associated primary pathological lesion. (+info)Molecular pathway involved in HIV-1-induced CNS pathology: role of viral regulatory protein, Tat. (5/1158)
The broad range of histological lesions associated with HIV-1 are somewhat subtle relative to the clinical manifestations that occur as a result of HIV infection. Although it is clear that HIV has a causative role in CNS disease, dementia appears to be a consequence of the infiltration of inflammatory cells and cytokine dysregulation rather than the amount of virus in CNS. The HIV transregulatory protein Tat plays an important intracellular as well as extracellular role in the dysregulation of cytokines. The cytokines and possibly chemokines that are induced by Tat modify the action of astrocytes such that the survival of neurons is compromised. Pathogenetic alteration induced by Tat involves a series of interactions between circulating monocyte/macrophages, endothelial cells, and astrocytes. Cytokine dysregulation induced by viral infection and extracellular Tat leads to alterations in expression of adhesion molecules and promotes migration of non-infected inflammatory cells into the CNS compartment. We demonstrate here that recombinant HIV-1 Tat protein introduced by stereotaxic injection into mouse brain can induce pathologically relevant alterations including macrophage invasion as well as astrocytosis. The mechanism of destruction of the CNS by Tat appears to involve autocrine and paracrine pathways that depend not only on Tat, but cytokine and chemokine signaling pathways that are altered by viral infection. In this review, we discuss various pathogenic effects of Tat in brain cells and provide experimental evidence for an increased TNF-alpha level in CSF in mice injected intracerebrally with Tat protein. (+info)Central nervous system sarcoidosis--diagnosis and management. (6/1158)
A series of 68 patients with neurosarcoidosis is reported, with particular emphasis on clinical aspects, diagnosis and treatment. A classification system based on clinical diagnostic probability is proposed, consisting of probable and definite disease, the latter being dependent on finding sarcoid granulomas on nervous system histology, which was obtained in 12 patients (18%). The role of investigations, including magnetic resonance imaging (MRI), chest radiography, Kveim skin test, Gallium 67 isotope scanning and cerebrospinal fluid (CSF) studies, is considered. Sixty-two percent of patients presented with nervous system disease, most commonly affecting the optic nerve and chiasm. Other common presentations included cranial nerve palsies, spinal cord and brainstem manifestations. Investigations yielding most diagnostic information included the Kveim test (41/48, 85% positive), raised CSF protein and/or cells (50/62, 81%) and gallium 67 scan (14/31, 45%). Eleven out of 29 patients (38%) patients showed meningeal enhancement on MRI scanning and 43% of scans demonstrated multiple white-matter lesions. Mean follow-up for the group was 4.6 years. Forty-seven patients were seen for > 18 months, and over half of these patients progressed despite corticosteroid and other immunosuppressive therapies. The benefit of a large patient database prospectively studied, with extended follow-up is discussed in order to learn more about prognosis and advance therapy in neurosarcoidosis. (+info)Complications of varicella in a defined central European population. (7/1158)
AIMS: To describe complications of varicella requiring hospitalisation in a defined population (canton of Bern) and to compare the hospitalisation rates for varicella with published data. METHODS: Retrospective analysis of hospital records of patients less than 16 years of age admitted with complications of varicella to the hospitals serving this population (University Children's Hospital of Bern and the Wildermeth Children's Hospital of Biel, Switzerland), and calculation of hospitalisation rates for varicella and its complications based on birth rates and varicella antibody prevalence rates. RESULTS: From 1986 to 1996, 113 cases (median age, 5.6 years) were identified. Younger siblings were overrepresented (odds ratio (OR), 1.42; 95% confidence interval (CI), 1.09 to 1.84). Central nervous system (CNS) complications (26 patients; 23%) were found predominantly in previously healthy children (relative risk, 7.1; 95% CI, 1.01 to 49.86). Group A beta haemolytic streptococci were recovered from only one of 35 patients with bacterial complications. The hospitalisation rates for primary varicella (9.2/10(4) cases; 95% CI, 7.4 to 11/10(4), skin infections (2.0/10(4) cases; 95% CI, 1.2 to 2.9/10(4), and pneumonia (0.8/10(4) cases; 95% CI, 0.3 to 1.3/10(4)) were significantly lower than reported previously. The CNS complication rate (2.2/10(4) cases; 95% CI, 1.3 to 3.1/10(4) was among the highest rates reported. CONCLUSIONS: The low hospitalisation rate in comparison with studies from elsewhere indicates that there is a large regional variability in complications associated with varicella. Such data should be taken into consideration when local varicella immunisation strategies are developed. (+info)C10 is a novel chemokine expressed in experimental inflammatory demyelinating disorders that promotes recruitment of macrophages to the central nervous system. (8/1158)
Chemokines may be important in the control of leukocytosis in inflammatory disorders of the central nervous system. We studied cerebral chemokine expression during the evolution of diverse neuroinflammatory disorders in transgenic mice with astrocyte glial fibrillary acidic protein-targeted expression of the cytokines IL-3, IL-6, or IFN-alpha and in mice with experimental autoimmune encephalomyelitis. Distinct chemokine gene expression patterns were observed in the different central nervous system inflammatory models that may determine the phenotype and perhaps the functions of the leukocytes that traffic into the brain. Notably, high expression of C10 and C10-related genes was found in the cerebellum and spinal cord of GFAP-IL3 mice with inflammatory demyelinating disease and in mice with experimental autoimmune encephalomyelitis. In both these neuroinflammatory models, C10 RNA and protein expressing cells were predominantly macrophage/microglia and foamy macrophages present within demyelinating lesions as well as in perivascular infiltrates and meninges. Intracerebroventricular injection of recombinant C10 protein promoted the recruitment of large numbers of Mac-1(+) cells and, to a much lesser extent, CD4(+) lymphocytes into the meninges, choroid plexus, ventricles, and parenchyma of the brain. Thus, C10 is a prominent chemokine expressed in the central nervous system in experimental inflammatory demyelinating disease that, we show, also acts as a potent chemotactic factor for the migration of these leukocytes to the brain. (+info)1. Neurodegenerative diseases: These are diseases that cause progressive loss of brain cells, leading to cognitive decline and motor dysfunction. Examples include Alzheimer's disease, Parkinson's disease, and Huntington's disease.
2. Stroke: A stroke occurs when blood flow to the brain is interrupted, leading to cell death and potential long-term disability.
3. Traumatic brain injury: This type of injury occurs when the brain is subjected to a sudden and forceful impact, such as in a car accident or fall.
4. Infections: Bacterial, viral, and fungal infections can all cause CNS diseases, such as meningitis and encephalitis.
5. Autoimmune disorders: These are conditions in which the immune system mistakenly attacks healthy cells in the brain, leading to inflammation and damage. Examples include multiple sclerosis and lupus.
6. Brain tumors: Tumors can occur in any part of the brain and can be benign or malignant.
7. Cerebrovascular diseases: These are conditions that affect the blood vessels in the brain, such as aneurysms and arteriovenous malformations (AVMs).
8. Neurodevelopmental disorders: These are conditions that affect the development of the brain and nervous system, such as autism spectrum disorder and attention deficit hyperactivity disorder (ADHD).
CNS diseases can have a significant impact on quality of life, and some can be fatal. Treatment options vary depending on the specific diagnosis and severity of the disease. Some CNS diseases can be managed with medication, while others may require surgery or other interventions.
Some common examples of CNSVD include:
1. Herpes simplex virus (HSV) encephalitis: This is an inflammation of the brain caused by the herpes simplex virus. It can cause fever, headache, confusion, and seizures.
2. West Nile virus (WNV) encephalitis: This is an infection of the brain caused by the West Nile virus, which is transmitted through the bite of an infected mosquito. Symptoms can include fever, headache, muscle weakness, and confusion.
3. Japanese encephalitis (JE): This is a viral infection that affects the brain and is transmitted through the bite of an infected mosquito. Symptoms can include fever, headache, seizures, and changes in behavior or cognitive function.
4. Rabies: This is a viral infection that affects the brain and is transmitted through the bite of an infected animal, usually a dog, bat, or raccoon. Symptoms can include fever, headache, agitation, and changes in behavior or cognitive function.
5. Enteroviral encephalitis: This is an infection of the brain caused by enteroviruses, which are common viruses that affect the gastrointestinal tract. Symptoms can include fever, vomiting, diarrhea, and changes in behavior or cognitive function.
The diagnosis of CNSVD typically involves a combination of physical examination, laboratory tests (such as blood tests or lumbar puncture), and imaging studies (such as CT or MRI scans). Treatment options vary depending on the specific disease and may include antiviral medications, supportive care, and rehabilitation.
Prevention of CNSVD includes avoiding exposure to mosquitoes and other vectors that can transmit disease, maintaining good hygiene practices (such as washing hands frequently), and getting vaccinated against diseases such as rabies and measles. In addition, taking steps to prevent head trauma and using protective equipment when engaging in activities that involve risk of head injury can help reduce the risk of CNSVD.
Overall, while central nervous system viral diseases can be serious and potentially life-threatening, early diagnosis and treatment can improve outcomes and prevent long-term complications. It is important to seek medical attention promptly if symptoms persist or worsen over time.
The symptoms of meningoencephalitis can vary depending on the cause, but common signs include fever, headache, stiff neck, confusion, seizures, and loss of consciousness. The disease can progress rapidly and can be fatal if not treated promptly.
Diagnosis is typically made through a combination of physical examination, laboratory tests (such as blood cultures and PCR), and imaging studies (such as CT or MRI scans). Treatment options depend on the underlying cause, but may include antibiotics, antiviral medications, and supportive care to manage symptoms and prevent complications.
Prognosis for meningoencephalitis depends on the severity of the disease and the promptness and effectiveness of treatment. In general, the prognosis is better for patients who receive prompt medical attention and have a mild form of the disease. However, the disease can be severe and potentially life-threatening, especially in young children, older adults, and those with weakened immune systems.
The most common types of CNS infections include:
1. Meningitis: Inflammation of the protective membranes (meninges) that cover the brain and spinal cord, often caused by bacteria or viruses.
2. Encephalitis: Inflammation of the brain tissue itself, usually caused by a virus.
3. Abscesses: Pockets of pus that form in the brain or spinal cord, typically caused by bacterial infections.
4. Cryptococcal infections: Caused by a fungus called Cryptococcus neoformans, often affecting people with weakened immune systems.
5. Toxoplasmosis: A parasitic infection caused by the Toxoplasma gondii parasite, which can affect the CNS in people with compromised immune systems.
Symptoms of CNS infections can vary depending on the specific type and severity of the infection, but may include fever, headache, confusion, seizures, weakness, and stiff neck. Diagnosis is typically made through a combination of physical examination, laboratory tests, and imaging studies such as CT or MRI scans.
Treatment of CNS infections depends on the underlying cause, but may involve antibiotics, antiviral medications, or antifungal drugs. In severe cases, hospitalization and supportive care such as intravenous fluids, oxygen therapy, and respiratory support may be necessary.
Prevention of CNS infections includes good hygiene practices such as frequent handwashing, avoiding close contact with people who are sick, and getting vaccinated against certain viruses that can cause CNS infections. Early diagnosis and prompt treatment are critical to preventing long-term complications of CNS infections and improving outcomes for patients.
Examples of Nervous System Diseases include:
1. Alzheimer's disease: A progressive neurological disorder that affects memory and cognitive function.
2. Parkinson's disease: A degenerative disorder that affects movement, balance and coordination.
3. Multiple sclerosis: An autoimmune disease that affects the protective covering of nerve fibers.
4. Stroke: A condition where blood flow to the brain is interrupted, leading to brain cell death.
5. Brain tumors: Abnormal growth of tissue in the brain.
6. Neuropathy: Damage to peripheral nerves that can cause pain, numbness and weakness in hands and feet.
7. Epilepsy: A disorder characterized by recurrent seizures.
8. Motor neuron disease: Diseases that affect the nerve cells responsible for controlling voluntary muscle movement.
9. Chronic pain syndrome: Persistent pain that lasts more than 3 months.
10. Neurodevelopmental disorders: Conditions such as autism, ADHD and learning disabilities that affect the development of the brain and nervous system.
These diseases can be caused by a variety of factors such as genetics, infections, injuries, toxins and ageing. Treatment options for Nervous System Diseases range from medications, surgery, rehabilitation therapy to lifestyle changes.
The word "SSPE" is an acronym for the disease name. It stands for "Subacute Sclerosing Panencephalitis."
Some common types of brain diseases include:
1. Neurodegenerative diseases: These are progressive conditions that damage or kill brain cells over time, leading to memory loss, cognitive decline, and movement disorders. Examples include Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS).
2. Stroke: This occurs when blood flow to the brain is interrupted, leading to cell death and potential long-term disability.
3. Traumatic brain injury (TBI): This refers to any type of head injury that causes damage to the brain, such as concussions, contusions, or penetrating wounds.
4. Infections: Viral, bacterial, and fungal infections can all affect the brain, leading to a range of symptoms including fever, seizures, and meningitis.
5. Tumors: Brain tumors can be benign or malignant and can cause a variety of symptoms depending on their location and size.
6. Cerebrovascular diseases: These conditions affect the blood vessels of the brain, leading to conditions such as aneurysms, arteriovenous malformations (AVMs), and Moyamoya disease.
7. Neurodevelopmental disorders: These are conditions that affect the development of the brain and nervous system, such as autism spectrum disorder, ADHD, and intellectual disability.
8. Sleep disorders: Conditions such as insomnia, narcolepsy, and sleep apnea can all have a significant impact on brain function.
9. Psychiatric disorders: Mental health conditions such as depression, anxiety, and schizophrenia can affect the brain and its functioning.
10. Neurodegenerative with brain iron accumulation: Conditions such as Parkinson's disease, Alzheimer's disease, and Huntington's disease are characterized by the accumulation of abnormal proteins and other substances in the brain, leading to progressive loss of brain function over time.
It is important to note that this is not an exhaustive list and there may be other conditions or factors that can affect the brain and its functioning. Additionally, many of these conditions can have a significant impact on a person's quality of life, and it is important to seek medical attention if symptoms persist or worsen over time.
The exact cause of ADC is not fully understood, but it is believed to be related to the progression of HIV infection in the brain. As HIV replicates in the brain, it can damage brain cells and disrupt normal brain function.
ADC typically affects individuals who have advanced HIV infection and a low CD4 cell count (a measure of immune system health). It is more common in women than men and tends to occur at an older age.
There are several symptoms of ADC, including:
1. Cognitive impairment: difficulty with memory, concentration, and decision-making.
2. Changes in personality and behavior: depression, anxiety, and agitation.
3. Difficulty with speech and language: slurred speech, trouble finding the right words.
4. Coordination and balance problems: unsteadiness, tremors, and difficulty with movement.
5. Seizures: ADC can cause seizures, which can be a sign of a more severe form of the disorder.
There is no cure for ADC, but treatment can help manage its symptoms and slow its progression. Treatment typically involves a combination of antiretroviral therapy (ART) to suppress HIV replication, and medications to manage cognitive and behavioral symptoms. In addition, supportive care, such as physical therapy and occupational therapy, can help improve quality of life.
In conclusion, AIDS Dementia Complex (ADC) is a serious neurological disorder that affects individuals with advanced HIV infection. It is characterized by cognitive impairment, changes in personality and behavior, and difficulty with speech and movement. While there is no cure for ADC, treatment can help manage its symptoms and slow its progression.
The most common demyelinating diseases include:
1. Multiple sclerosis (MS): An autoimmune disease that affects the CNS, including the brain, spinal cord, and optic nerves. MS causes inflammation and damage to the myelin sheath, leading to a range of symptoms such as muscle weakness, vision problems, and cognitive difficulties.
2. Acute demyelination: A sudden, severe loss of myelin that can be caused by infections, autoimmune disorders, or other factors. This condition can result in temporary or permanent nerve damage.
3. Chronic inflammatory demyelination (CIDP): A rare autoimmune disorder that causes progressive damage to the myelin sheath over time. CIDP can affect the CNS and the peripheral nervous system (PNS).
4. Moore's disease: A rare genetic disorder that results in progressive demyelination of the CNS, leading to a range of neurological symptoms including muscle weakness, seizures, and cognitive difficulties.
5. Leukodystrophies: A group of genetic disorders that affect the development or function of myelin-producing cells in the CNS. These conditions can cause progressive loss of myelin and result in a range of neurological symptoms.
Demyelinating diseases can be challenging to diagnose, as the symptoms can be similar to other conditions and the disease progression can be unpredictable. Treatment options vary depending on the specific condition and its severity, and may include medications to reduce inflammation and modulate the immune system, as well as rehabilitation therapies to help manage symptoms and improve quality of life.
The most common symptoms of enterovirus infections include:
* Diarrhea
* Vomiting
* Fever
* Abdominal pain
* Headache
* Fatigue
In some cases, enterovirus infections can lead to more severe complications, such as:
* Hand, foot, and mouth disease (HFMD)
* Aseptic meningitis
* Encephalitis
* Myocarditis
Enteroviruses are highly contagious and can be spread through:
* Close contact with an infected person
* Contaminated food and water
* Insect vectors
There is no specific treatment for enterovirus infections, but symptoms can be managed with supportive care, such as hydration, rest, and pain relief. Antiviral medications may be used in severe cases.
Prevention measures include:
* Good hygiene practices, such as frequent handwashing
* Avoiding close contact with people who are sick
* Properly preparing and storing food and water
* Avoiding sharing items that come into contact with the mouth, such as utensils and drinking glasses.
1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.
2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.
3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.
4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.
5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.
6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.
7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.
8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.
9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.
10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.
Benign CNS neoplasms include:
1. Meningiomas: These are the most common type of benign CNS tumor, arising from the meninges (the membranes covering the brain and spinal cord).
2. Acoustic neuromas: These tumors arise from the nerve cells that connect the inner ear to the brain.
3. Pineal gland tumors: These are rare tumors that occur in the pineal gland, a small gland located in the brain.
4. Craniopharyngiomas: These are rare tumors that arise from the remnants of the embryonic pituitary gland and can cause a variety of symptoms including headaches, vision loss, and hormonal imbalances.
Malignant CNS neoplasms include:
1. Gliomas: These are the most common type of malignant CNS tumor and arise from the supporting cells of the brain called glial cells. Examples of gliomas include astrocytomas, oligodendrogliomas, and medulloblastomas.
2. Lymphomas: These are cancers of the immune system that can occur in the CNS.
3. Melanomas: These are rare tumors that arise from the pigment-producing cells of the skin and can spread to other parts of the body, including the CNS.
4. Metastatic tumors: These are tumors that have spread to the CNS from other parts of the body, such as the breast, lung, or colon.
The diagnosis and treatment of central nervous system neoplasms depend on the type, size, location, and severity of the tumor, as well as the patient's overall health and medical history. Treatment options can include surgery, radiation therapy, chemotherapy, targeted therapy, and immunotherapy.
The prognosis for CNS neoplasms varies depending on the type of tumor and the effectiveness of treatment. In general, gliomas have a poorer prognosis than other types of CNS tumors, with five-year survival rates ranging from 30% to 60%. Lymphomas and melanomas have better prognoses, with five-year survival rates of up to 80%. Metastatic tumors have a more guarded prognosis, with five-year survival rates depending on the primary site of the cancer.
In summary, central nervous system neoplasms are abnormal growths of tissue in the brain and spinal cord that can cause a variety of symptoms and can be benign or malignant. The diagnosis and treatment of these tumors depend on the type, size, location, and severity of the tumor, as well as the patient's overall health and medical history. The prognosis for CNS neoplasms varies depending on the type of tumor and the effectiveness of treatment, but in general, gliomas have a poorer prognosis than other types of CNS tumors.
There are many different types of ANS diseases, including:
1. Dysautonomia: a general term that refers to dysfunction of the autonomic nervous system.
2. Postural orthostatic tachycardia syndrome (POTS): a condition characterized by rapid heart rate and other symptoms that occur upon standing.
3. Neurocardiogenic syncope: a form of fainting caused by a sudden drop in blood pressure.
4. Multiple system atrophy (MSA): a progressive neurodegenerative disorder that affects the autonomic nervous system and other parts of the brain.
5. Parkinson's disease: a neurodegenerative disorder that can cause autonomic dysfunction, including constipation, urinary incontinence, and erectile dysfunction.
6. Dopamine deficiency: a condition characterized by low levels of the neurotransmitter dopamine, which can affect the ANS and other body systems.
7. Autonomic nervous system disorders associated with autoimmune diseases, such as Guillain-Barré syndrome and lupus.
8. Trauma: physical or emotional trauma can sometimes cause dysfunction of the autonomic nervous system.
9. Infections: certain infections, such as Lyme disease, can affect the autonomic nervous system.
10. Genetic mutations: some genetic mutations can affect the functioning of the autonomic nervous system.
Treatment for ANS diseases depends on the specific condition and its underlying cause. In some cases, medication may be prescribed to regulate heart rate, blood pressure, or other bodily functions. Lifestyle changes, such as regular exercise and stress management techniques, can also be helpful in managing symptoms. In severe cases, surgery may be necessary to correct anatomical abnormalities or repair damaged nerves.
Some common examples of digestive system diseases include:
1. Irritable Bowel Syndrome (IBS): This is a chronic condition characterized by abdominal pain, bloating, and changes in bowel habits such as constipation or diarrhea.
2. Inflammatory Bowel Disease (IBD): This includes conditions such as Crohn's disease and ulcerative colitis, which cause chronic inflammation in the digestive tract.
3. Gastroesophageal Reflux Disease (GERD): This is a condition where stomach acid flows back up into the esophagus, causing heartburn and other symptoms.
4. Peptic Ulcer: This is a sore on the lining of the stomach or duodenum (the first part of the small intestine) that can cause pain, nausea, and vomiting.
5. Diverticulosis: This is a condition where small pouches form in the wall of the colon, which can become inflamed and cause symptoms such as abdominal pain and changes in bowel habits.
6. Constipation: This is a common condition where the stool is hard and difficult to pass, which can be caused by a variety of factors such as poor diet, dehydration, or certain medications.
7. Diabetes: This is a chronic condition that affects how the body regulates blood sugar levels, which can also affect the digestive system and cause symptoms such as nausea, vomiting, and abdominal pain.
8. Celiac Disease: This is an autoimmune disorder where the immune system reacts to gluten, a protein found in wheat, barley, and rye, causing inflammation and damage to the small intestine.
9. Lipidosis: This is a condition where there is an abnormal accumulation of fat in the body, which can cause symptoms such as abdominal pain, nausea, and vomiting.
10. Sarcoidosis: This is a chronic inflammatory disease that can affect various organs in the body, including the digestive system, causing symptoms such as abdominal pain, diarrhea, and weight loss.
It's important to note that this list is not exhaustive and there are many other conditions that can cause abdominal pain. If you are experiencing persistent or severe abdominal pain, it's important to seek medical attention to determine the underlying cause and receive proper treatment.
Peripheral Nervous System Diseases can result from a variety of causes, including:
1. Trauma or injury
2. Infections such as Lyme disease or HIV
3. Autoimmune disorders such as Guillain-Barré syndrome
4. Genetic mutations
5. Tumors or cysts
6. Toxins or poisoning
7. Vitamin deficiencies
8. Chronic diseases such as diabetes or alcoholism
Some common Peripheral Nervous System Diseases include:
1. Neuropathy - damage to the nerves that can cause pain, numbness, and weakness in the affected areas.
2. Multiple Sclerosis (MS) - an autoimmune disease that affects the CNS and PNS, causing a range of symptoms including numbness, weakness, and vision problems.
3. Peripheral Neuropathy - damage to the nerves that can cause pain, numbness, and weakness in the affected areas.
4. Guillain-Barré syndrome - an autoimmune disorder that causes muscle weakness and paralysis.
5. Charcot-Marie-Tooth disease - a group of inherited disorders that affect the nerves in the feet and legs, leading to muscle weakness and wasting.
6. Friedreich's ataxia - an inherited disorder that affects the nerves in the spine and limbs, leading to coordination problems and muscle weakness.
7. Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - an autoimmune disorder that causes inflammation of the nerves, leading to pain, numbness, and weakness in the affected areas.
8. Amyotrophic Lateral Sclerosis (ALS) - a progressive neurological disease that affects the nerve cells responsible for controlling voluntary muscle movement, leading to muscle weakness, atrophy, and paralysis.
9. Spinal Muscular Atrophy - an inherited disorder that affects the nerve cells responsible for controlling voluntary muscle movement, leading to muscle weakness and wasting.
10. Muscular Dystrophy - a group of inherited disorders that affect the nerve cells responsible for controlling voluntary muscle movement, leading to muscle weakness and wasting.
It's important to note that this is not an exhaustive list and there may be other causes of muscle weakness. If you are experiencing persistent or severe muscle weakness, it is important to see a healthcare professional for proper evaluation and diagnosis.
The exact cause of CNS vasculitis is not fully understood, but it is believed to be an autoimmune disorder, meaning that the immune system mistakenly attacks healthy tissues in the CNS. The condition can occur at any age, but it most commonly affects adults between the ages of 40 and 60.
Symptoms of CNS vasculitis can vary depending on the location and severity of the inflammation, but may include:
* Headaches
* Confusion
* Memory loss
* Seizures
* Weakness or numbness in the limbs
* Vision problems
* Speech difficulties
Diagnosis of CNS vasculitis typically involves a combination of physical examination, medical history, and diagnostic tests such as MRI or CT scans, lumbar puncture, and blood tests. Treatment options for CNS vasculitis vary depending on the severity of the condition and may include corticosteroids, immunosuppressive drugs, and plasmapheresis. In severe cases, surgery may be necessary to relieve pressure on the brain or spinal cord.
Overall, CNS vasculitis is a serious condition that can have significant neurological consequences if left untreated. Early diagnosis and aggressive treatment are critical to prevent long-term damage and improve outcomes for patients with this condition.
Central nervous system disease
Central nervous system viral disease
Inflammatory demyelinating diseases of the central nervous system
Nervous system disease
Lesional demyelinations of the central nervous system
Licarbazepine
Ziprasidone
Fluvoxamine
Athetosis
William Shell
Demyelinating disease
Jordi Casals i Ariet
White dog shaker syndrome
Diffuse myelinoclastic sclerosis
Granulomatous meningoencephalitis
Pericyte
Andrzej Grzybowski
White matter
Hans Reese
Poliovirus
Vincent Racaniello
Acute disseminated encephalomyelitis
Wernicke encephalopathy
Organ-on-a-chip
Vincent Zigas
Milroy Lectures
Pallesthesia
Oligoclonal band
Physical examination
Driving in the United States
Brain ischemia
Pauline Cafferkey
Susac's syndrome
Multiple system atrophy
Orotomide
Papillary tumors of the pineal region
Myelin-associated glycoprotein
Rocky Mountain spotted fever
Amphiura filiformis
Nkx2-2as
Meningococcal myelitis
Tetratricopeptide repeat protein 39B
Methylazoxymethanol acetate
List of Old Bedford Modernians
Toll-like receptor 6
Zinc deficiency
Conium maculatum
Zachary Smith Reynolds
List of diseases (C)
Prince Andrew, Duke of York
Jeffrey Macklis
Constantin Stere
COVID-19
Spinal cord
Pembrolizumab
Ferdinando Giorgetti
Revolutions of 1848
Striated muscle tissue
Milk-alkali syndrome
Histamine H3 receptor
Raccoon Roundworm Infection Associated with Central Nervous System Disease and Ocular Disease - Six States, 2013-2015 | MMWR
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WHO HQ Library catalog
Corvelva Association - Did you know that some vaccines have been associated with demyelinating diseases of the central nervous...
Treatment Protocol of Replagal for Patients With Fabry Disease - Full Text View - ClinicalTrials.gov
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CNN.com - Fear and mystery of cross-species killer - Oct. 17, 2002
Krabbe disease: MedlinePlus Medical Encyclopedia
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Autonomic nervou5
- Any problem with the functioning of the autonomic nervous system, which controls unconscious body functions that affect the bladder, bowels, sweating, sexual function and blood pressure. (michaeljfox.org)
- It also receives considerable innervation from the autonomic nervous system . (newworldencyclopedia.org)
- Thus, it generally is considered a part of the autonomic nervous system, which is one of the two main divisions of the peripheral nervous system. (newworldencyclopedia.org)
- It commonly is considered as part of the autonomic nervous system , which is that part of the peripheral nervous system that largely acts independent of conscious control (involuntarily). (newworldencyclopedia.org)
- The other subdivisions of the autonomic nervous system are the sympathetic nervous system and the parasympathetic nervous system. (newworldencyclopedia.org)
Including Parkinson's disease1
- In the pathological state α-syn changes from a soluble monomer to pathological oligomers and fibrils, which participate in the occurrence and development of various central nervous system diseases, including Parkinson's disease (PD), Lewy body dementia, and cerebrovascular diseases. (conditionmed.org)
Neurological6
- 7 The disease is characterised by demyelination and axonal loss leading to neurological impairment and severe disability. (businesswire.com)
- 8,9 Relapsing forms of MS include clinically isolated syndrome, relapsing-remitting MS (which makes up 85 percent of all MS cases), and secondary progressive MS. 10 In addition to the debilitating neurological symptoms of the disease, patients often also suffer from "hidden symptoms," namely fatigue and depression, both of which are major contributors to reduced quality of life. (businesswire.com)
- Neurological diseases are recognized as major causes of disability and mortality worldwide. (mdpi.com)
- A growing body of evidence suggests that inflammatory processes and an imbalance in the composition and function of the gut microbiome, which play a critical role in the pathogenesis of various neurological diseases and dietary interventions, such as the Mediterranean diet the DASH diet, or the ketogenic diet can have beneficial effects on their course. (mdpi.com)
- Myelin is also relevant from a clinical perspective, given that demyelination is often observed in several neurological diseases such as multiple sclerosis ( Höftberger & Lassmann, 2018 ). (biorxiv.org)
- In advanced stages the disease affects the central nervous system, causing severe neurological and mental disorders and making the individual dependent on others. (who.int)
Complications2
- However, there are many treatment -related complications , including organ disorders, graft-versus-host disease (GVHD), and infectious diseases . (bvsalud.org)
- Furthermore, there are many unclear points regarding central nervous system (CNS) complications , and the prognosis in patients with CNS complications is extremely poor. (bvsalud.org)
Symptoms4
- The study, which enrolled 200 U.S. patients with RMS measured multiple sclerosis (MS)-related fatigue and its impact on daily life using the Fatigue Symptoms and Impacts Questionnaire - Relapsing Multiple Sclerosis (FSIQ-RMS), a novel disease-specific scale developed using methods consistent with the U.S. Food & Drug Administration guidelines. (businesswire.com)
- Many of the symptoms of Parkinson's disease are brought on by loss of or damage to dopamine neurons in this region, which encompasses the striatum, the subthalamic nucleus, and the substantia nigra. (michaeljfox.org)
- The illness was first identified in 1985 when the vet, puzzled by odd symptoms he had seen in cattle, consulted scientists at the Central Veterinary Laboratory in Weybridge, Surrey. (cnn.com)
- The WHO says human sufferers of the disease usually experience psychiatric symptoms early in the illness, which most commonly take the form of depression and anxiety or less often, a schizophrenia-like psychosis. (cnn.com)
Disorders3
- Dr. Turner specializes in cognitive behavioral neurology, memory disorders, Alzheimer's disease and Neurodegenerative dementias. (healthwellfoundation.org)
- However, there are a number of disorders that can affect the enteric nervous system and some evidence for age-associated changes in innervation contributing to increasing disorders in the elderly. (newworldencyclopedia.org)
- The most-reported TEAEs among all treatment groups were nervous system disorders and infections and infestations. (medscape.com)
Affects2
- Multiple sclerosis (MS) is a potentially disabling disease that affects the brain and spinal cord. (medicalnewstoday.com)
- Rabies is a deadly disease that affects the central nervous system and is most commonly transferred to humans through a bite from a rabid animal. (cdc.gov)
Inflammatory2
- Pediatric central nervous system infections and inflammatory white matter disease. (wakehealth.edu)
- MS is a chronic autoimmune inflammatory disease of the central nervous system. (businesswire.com)
Intestinal1
- Intestinal blood supply and mucosal epithelial water and electrolyte transport are also regulated by the enteric nervous system. (newworldencyclopedia.org)
Emerging Infectio2
Infections1
- Virus infections and the developing nervous system / edited by R. T. Johnson and G. Lyon. (who.int)
Alzheimer's Disease5
- Alzheimer's disease ranks as one of the toughest nuts to crack within drug discovery and development. (healthwellfoundation.org)
- Dr. Porsteinsson is the Director of the University of Rochester Alzheimer's Disease Care, Research and Education Program and has devoted his career to the care and study of individuals with… more . (healthwellfoundation.org)
- According to a report from the Alzheimer's Foundation of America, as many as 5.1 million Americans may have Alzheimer's Disease (AD), a figure that is expected to triple to nearly 13.8 million by 2050. (healthwellfoundation.org)
- Due to the dynamic progress of diseases such as Alzheimer's disease (AD), Parkinson's Disease (PD), Schizophrenia, Depression, and Multiple Sclerosis (MD), scientists are mobilized to look for new and more effective methods of interventions. (mdpi.com)
- Herein, we will review advances in the understanding of the role of several proteins of the UPS in Alzheimer's disease (AD) and functional recovery after spinal cord injury (SCI). (frontiersin.org)
Zoonotic1
- My fascination for being a "disease detective" stuck with me as I grew older and I focused my schooling on microbiology and Zoonotic diseases (disease that is spread from animals to humans). (cdc.gov)
Therapeutic targets1
- We also propose potential clinical applications of α-syn as helpful biomarkers or therapeutic targets in different central nervous system diseases. (conditionmed.org)
Dysfunction1
- The copper panel revealed normal copper levels, which excluded Wilson disease as a cause of central nervous system dysfunction. (medscape.com)
Severe5
- Infection can result in fatal human disease or severe neurologic outcomes if it is not treated rapidly. (cdc.gov)
- Although raccoons are typically asymptomatic when infected with the parasite, the larval form of Baylisascaris procyonis can result in fatal human disease or severe neurologic outcomes if not treated rapidly. (cdc.gov)
- A movement disorder sometimes confused with Parkinson's disease that manifests in low, repetitive, involuntary, writhing movements of the arms, legs, hands, and neck that are often especially severe in the fingers and hands. (michaeljfox.org)
- PeV-A3 is most often associated with severe disease. (cdc.gov)
- Poorly controlled maternal diabetes mellitus (Oligohydramnios may also be seen if severe vascular disease is present. (medscape.com)
Nerveux central2
Multiple Sclerosis1
- Prof. Montalban established the first MS center in Spain (The Multiple Sclerosis Center of Catalonia - Cemcat), championing a holistic approach to managing the disease, and incorporating digital approaches to better track individuals' disease activity. (nationalmssociety.org)
Spinal cord3
- However, many researchers suggest that the condition is an autoimmune disease that attacks the myelin sheath - that is, the protective layer surrounding the nerves that help electrical signals to travel from the brain to the rest of the body - in the brain and spinal cord. (medicalnewstoday.com)
- The enteric nervous system is very complex and has many more neurons than the spinal cord . (newworldencyclopedia.org)
- The peripheral nervous system is that part of the vertebrate nervous system outside of the brain and spinal cord. (newworldencyclopedia.org)
Brain8
- Control of brain and nerve diseases : a world-wide challenge. (who.int)
- It is a type of brain disease called leukodystrophy. (medlineplus.gov)
- The chemical measurements are used to measure the effects of variability in function, disease, and pharmacology on the concentrations of brain glutamate, glutamine, GABA and other compounds that are important for brain activity. (yale.edu)
- It is possible to observe the synthesis of glutamate, glutamine, GABA, and other compounds in the intact brain, with collaborative studies to examine other systems. (yale.edu)
- The goals of the laboratory are to acquire the necessary data and create concrete mathematical expressions of the metabolic regulation of metabolism in the brain and other systems. (yale.edu)
- A decade later in 1996 the British Government conceded people were falling victim to a degenerative new brain disease linked to BSE. (cnn.com)
- His work on the natural history of MS and tracing the meaning of MRI lesions in specific areas of the brain have contributed much to our understanding of MS, as well as informing the development of the McDonald Diagnostic Criteria for MS, which have made diagnosing the disease faster and more precise. (nationalmssociety.org)
- Similarities between the enteric nervous system and the central nervous system has led to the the ENS being referred to as the "second brain. (newworldencyclopedia.org)
Myelin1
- Myelin is a key component of the central nervous system. (biorxiv.org)
Biomarker4
- In addition, various forms of α-syn can be transmitted through different body fluids, raising the possibility that it can be used as a biomarker to help diagnose central nervous system diseases. (conditionmed.org)
- This review explains the physiological functions of α-syn, the effects of different forms of pathological α-syn, summarizes the research progress relating to α-syn in different forms and sources as biomarkers for PD, and explores the potential role of α-syn in other central nervous system diseases and the possibility of α-syn as a biomarker for these diseases. (conditionmed.org)
- For example, high blood pressure is a biomarker of potential cardiovascular disease. (michaeljfox.org)
- No validated biomarker of Parkinson's disease currently exists. (michaeljfox.org)
Infectious agents1
- Novel infectious agents and the central nervous system. (who.int)
Therapies3
- With models, researchers can study the mechanisms of a disease and test therapies. (michaeljfox.org)
- At present, disease-modifying therapies (DMTs) are the best strategy to slow the course of MS. DMTs reduce the frequency and severity of relapses - or attacks and exacerbations - and the development of new lesions, and slow down the progression of disability. (medicalnewstoday.com)
- Disease-modifying therapies (DMTs), particularly targeted biologics, have revolutionized the treatment of MS, including RRMS. (medscape.com)
Cardiovascular1
- 45. Cardiovascular disease is diagnosed. (medscape.com)
Alpha-synuclein2
- Alpha-synuclein (α-syn) is a protein widely expressed in the central nervous system. (conditionmed.org)
- Aggregation of the protein alpha-synuclein is found in Lewy bodies, a pathological hallmark of Parkinson's disease. (michaeljfox.org)
Tuberculosis2
Progression3
- Preclinical studies have shown that AMT-130 lowers huntingtin protein and is associated with decreased progression of Huntington's Disease signs in animal models. (clinicaltrials.gov)
- This trial consists of a blinded 12-month (Cohort 1 & 2) and 12-month (Cohort 3A & 3B) Core Study Period to evaluate the safety and potential impact of AMT-130 on disease progression and an unblinded 4-year Long-Term Period with periodic follow-up visits to evaluate the safety of AMT-130 and disease progression in treated individuals. (clinicaltrials.gov)
- The aim of this review was to take a closer look at the role of diet and its ingredients in modulating inflammation associated with the development and/or progression of central nervous system diseases. (mdpi.com)
Gastrointestinal system3
- The enteric nervous system (ENS) is that part of the peripheral nervous system of vertebrates that plays a fundamental role in control of the gastrointestinal system. (newworldencyclopedia.org)
- The enteric nervous system is embedded in the lining of the gastrointestinal system, including innervating areas around the intestines , pancreas , and gall bladder . (newworldencyclopedia.org)
- Neoplasia are tumors that grow and obstruct the gastrointestinal system. (dog-health-guide.org)
Clinical3
- Baylisascariasis is not a nationally notifiable disease in the United States, and little is known about how commonly it occurs or the range of clinical disease in humans. (cdc.gov)
- One of the cardinal clinical features of Parkinson's disease, the slowing down and loss of spontaneous and voluntary movement. (michaeljfox.org)
- Ongoing surveillance will improve understanding of the incidence and clinical severity of this emerging disease. (cdc.gov)
Immune system3
- The idea behind autologous hematopoietic stem cell transplantation (AHSCT) is to "reboot" the immune system in people with MS. Hematopoietic, or blood cell-producing, stems cells derived from the person's own (autologous) blood or bone marrow are collected and stored. (medicalnewstoday.com)
- White blood cells, which form part of the immune system and are found in the lymph glands, were isolated as one of the high-risk tissues for BSE infection. (cnn.com)
- The enteric nervous system may also be involved in a complex interplay with the immune system (Hopley and van Schalkwyk 2006). (newworldencyclopedia.org)
Parasitic1
- HAT is the only vector-borne parasitic disease with a geographical distribution limited to the African continent. (who.int)
Parkinson's5
- A class of drugs used to treat mild to moderate dementia in Parkinson's disease. (michaeljfox.org)
- A genetic mutation in this protein is the basis for a rare inherited form of Parkinson's disease. (michaeljfox.org)
- A class of drugs often effective in reducing the tremor of Parkinson's disease. (michaeljfox.org)
- Some studies have linked oxidative damage to Parkinson's disease. (michaeljfox.org)
- A medicine used to treat Parkinson's disease. (michaeljfox.org)
Digestive system2
- It works harmoniously with the various organs of the digestive system, and in cooperation with the rest of the nervous system, to allow proper digestive function. (newworldencyclopedia.org)
- Conditions that block the digestive system and causes a dog stomach blockage includes ulcers and gastritis. (dog-health-guide.org)
DMTs1
- Progressive multifocal leukoencephalopathy (PML), a rare and potentially fatal demyelinating disease of the central nervous system, is associated with some DMTs - notably ref-NTZ. (medscape.com)
Bowel1
- The complex behaviors of the bowel are regulated by the enteric nervous system, including propulsive peristalitic movement and various movements that result in mixing. (newworldencyclopedia.org)
Diagnosis3
- Central nervous system diseases are characterized by slow onset, occultation, and progressive aggravation, which makes the diagnosis of these diseases very difficult. (conditionmed.org)
- Moreover, many diseases can only be identified at autopsy, so more effective methods are needed for early and differential diagnosis. (conditionmed.org)
- Confirmed diagnosis of Fabry disease. (clinicaltrials.gov)
Pulmonary2
- Concurrent culture positive pulmonary disease was found in 4 (50%) of 8 patients tested. (cdc.gov)
- 44. Pulmonary disease is diagnosed. (medscape.com)
Endocrine1
- 55. Endocrine disease is diagnosed. (medscape.com)
Progresses1
- 2. The disease progresses through two stages following an asymptomatic period of several weeks or months. (who.int)
Patients6
- During May 2013-December 2015, seven cases of baylisascariasis not already described in the literature were identified among patients in the United States through testing at CDC, including six cases of central nervous system disease and one of ocular disease. (cdc.gov)
- This study will evaluate the safety and efficacy of Replagal in patients with Fabry disease who are either naive to treatment, who were previously treated with agalsidase beta, or who had previously received Replagal. (clinicaltrials.gov)
- Patients diagnosed with Fabry disease who have not previously received treatment, who have received agalsidase beta, or who had previously received Replagal will be eligible to enroll in the study and will receive Replagal at a dose of 0.2 mg/kg body weight administered by an IV infusion over 40 minutes every other week. (clinicaltrials.gov)
- An Open-label Treatment Protocol to Evaluate the Safety of Replagal Treatment in Patients With Fabry Disease. (clinicaltrials.gov)
- Patients with HIV infection may have a form of the disease that closely resembles the juvenile type. (medscape.com)
- UBB+1, which arises through a frame-shift mutation in the ubiquitin gene that adds 19 amino acids to the C-terminus of ubiquitin, inhibits proteasomal function and is associated with increased neurofibrillary tangles in patients with AD, Pick's disease and Down's syndrome. (frontiersin.org)
Humans3
- Still mad cow disease, and its jump from cattle to humans, mystifies scientists and inspires public fear. (cnn.com)
- Despite previous denials that BSE could infect humans, ministers now accepted variant Creutzfeldt-Jakob disease (vCJD) was most likely caused by infected meat. (cnn.com)
- But many questions still need answers -- how did BSE develop in cattle, how did the disease cross species to infect humans as vCJD and what factors affect whether a human will contract the disease. (cnn.com)
Onset4
- Early-onset Krabbe disease appears in the first months of life. (medlineplus.gov)
- Late-onset Krabbe disease begins in late childhood or early adolescence. (medlineplus.gov)
- With late onset Krabbe disease, vision problems may appear first, followed by walking difficulties and rigid muscles. (medlineplus.gov)
- On average, infants with early-onset Krabbe disease die before age 2. (medlineplus.gov)
Drugs1
- Unfortunately, due to lack of regular surveillance activities and reduced resource allocation to HAT as well as changing health priorities and nonavailability of drugs, the disease has been neglected. (who.int)
Centers3
- Centers for Disease Control and Prevention. (cdc.gov)
- The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
- The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to inform clinicians and public health departments that parechovirus (PeV) is currently circulating in the United States. (cdc.gov)
Possibility1
- Turkey's geographical position, its close proximity to countries in a state of war and with low vaccination coverage, and receiving extensive immigration always raises the possibility of a reintroduction of formerly eradicated vaccine-preventable diseases such as polio (7). (who.int)
Coordination1
- This system is capable of autonomous functions, acting independent of conscious control, such as the coordination of reflexes. (newworldencyclopedia.org)
Protein3
- The most accepted explanation is that the disease is caused by prions -- self-replicating proteins that contaminate neighbouring protein cells. (cnn.com)
- The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in eukaryotes. (frontiersin.org)
- The ubiquitin-proteasome system (UPS) is a major intracellular protein degradation system ( Schwartz and Ciechanover, 2009 ). (frontiersin.org)
Dementia1
- Formed in 1980, the Alzheimer's Association advances research to end Alzheimer's and dementia while enhancing care for those living with the disease. (healthwellfoundation.org)
Treatment2
- There is no specific treatment for Krabbe disease. (medlineplus.gov)
- Some people have had a bone marrow transplant in the early stages of the disease, but this treatment has risks. (medlineplus.gov)