Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.
An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.
A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, usually causing an inapparent intestinal infection in mice. A small number of mice may show signs of flaccid paralysis.
The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.
A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.
A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A subclass of developmentally regulated lamins having a neutral isoelectric point. They are found to disassociate from nuclear membranes during mitosis.
The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
Diseases in any part of the GASTROINTESTINAL TRACT or the accessory organs (LIVER; BILIARY TRACT; PANCREAS).
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)

Neurologic complications of systemic cancer. (1/1158)

Neurologic complications occur frequently in patients with cancer. After routine chemotherapy, these complications are the most common reason for hospitalization of these patients. Brain metastases are the most prevalent complication, affecting 20 to 40 percent of cancer patients and typically presenting as headache, altered mental status or focal weakness. Other common metastatic complications are epidural spinal cord compression and leptomeningeal metastases. Cord compression can be a medical emergency, and the rapid institution of high-dose corticosteroid therapy, radiation therapy or surgical decompression is often necessary to preserve neurologic function. Leptomeningeal metastases should be suspected when a patient presents with neurologic dysfunction in more than one site. Metabolic encephalopathy is the common nonmetastatic cause of altered mental status in cancer patients. Cerebrovascular complications such as stroke or hemorrhage can occur in a variety of tumor-related conditions, including direct invasion, coagulation disorders, chemotherapy side effects and nonbacterial thrombotic endocarditis. Radiation therapy is the most commonly employed palliative measure for metastases. Chemotherapy or surgical removal of tumors is used in selected patients.  (+info)

Loss of 123I-MIBG uptake by the heart in Parkinson's disease: assessment of cardiac sympathetic denervation and diagnostic value. (2/1158)

Myocardial imaging with 123I-metaiodobenzylguanidine (MIBG) was performed on 35 patients with Parkinson's disease and 24 control subjects to evaluate cardiac sympathetic function in patients with Parkinson's disease, verify this phenomenon and examine whether myocardial MIBG uptake and clearance are correlated with the clinical severity of Parkinson's disease. METHODS: We studied 35 patients with Parkinson's disease and 24 control subjects with other central nervous system diseases. The latter group consisted of 12 subjects with other neurodegenerative disorders (4 with spinocerebellar degeneration, 2 with amyotrophic lateral sclerosis, 3 with progressive supranuclear palsy and 3 with corticobasal degeneration and 12 patients with cerebral infarction (CI), 6 with vascular parkinsonism and 6 without it. Early and delayed images of the anterior view were obtained 15 min and 4 h after injection of 123I-MIBG, respectively. MIBG uptake was quantified by calculating a heart-to-mediastinum count (H/M) ratio. RESULTS: The H/M ratio was markedly reduced in the patients with Parkinson's disease (II to V on the Hoehn and Yahr scale) compared with the control subjects. None of the subjects with neurodegenerative diseases showed a marked decrease in myocardial MIBG uptake nor did any subject with CI. CONCLUSION: Our findings indicate that, in Parkinson's disease, a reduction in myocardial MIBG uptake is a very common, specific phenomenon that can be used to detect cardiac autonomic dysfunction to diagnose Parkinson's disease, particularly in patients without typical signs and symptoms.  (+info)

A five-year assessment of controlled trials of in-patient and out-patient treatment and of plaster-of-Paris jackets for tuberculosis of the spine in children on standard chemotherapy. Studies in Masan and Pusan, Korea. Fifth report of the Medical Research Council Working Party on tuberculosis of the spine. (3/1158)

In two centres in Korea 350 patients with a diagnosis of tuberculosis of the thoracic and/or lumbar spine were allocated at random: in Masan to in-patient rest in bed (IP) for six months followed by out-patient treatment or to ambulatory out-patient treatment (OP) from the start; in Pusan to out-patient treatment with a plaster-of-Paris jacket (J) for nine months or to ambulatory treatment without any support (No J). All patients recieved chemotherapy with PAS with isoniazid for eighteen months, either supplemented with streptomycin for the first three months (SPH) or without this supplement (PH), by random allocation. The main analysis of this report concerns 299 patients (eighty-three IP, eighty-three OP, sixty-three J, seventy No J; 143 SPH, 156 PH). Pre-treatment factors were similar in both centres except that the patients in Pusan had, on average, less extensive lesions although in a greater proportion the disease was radiographically active. One patient (J/SPH) died with active spinal disease and three (all No J/SPH) with paraplegia. A fifth patient (IP/PH) who died from cardio respiratory failure also had pulmonary tuberculosis. Twenty-three patients required operation and/or additional chemotherapy for the spinal lesion. A sinus or clinically evident abscess was either present initially or developed during treatment in 41 per cent of patients. Residual lesions persisted in ten patients (four IP, two OP, one J, three No J; six SPH, four PH) at five years. Thirty-two patients had paraparesis on admission or developing later. Complete resolution occurred in twenty on the allocated regimen and in eight after operation or additional chemotherapy or both. Of the remaining four atients, all of whom had operation and additional chemotherapy, three died and one still had paraparesis at five years. Of 295 patients assessed at five years 89 per cent had a favourable status. The proportions of the patients responding favourably were similar in the IP (91 per cent) and OP (89 per cent) series, in the J (90 per cent) and No J (84 per cent) series and in the SPH (86 per cent) and PH (92 per cent) series.  (+info)

Fatal outcome due to cyclosporine neurotoxicity with associated pathological findings. (4/1158)

We present a case of death likely to be directly due to cyclosporine (CsA) neurotoxicity. To date, there have been no reports of deaths directly due to CsA neurotoxicity, nor has an associated histological lesion been described independent of confounding processes. A 54-year-old male received an HLA-matched-unrelated BMT for CML. He developed progressive encephalopathy and on day +79 had a generalized seizure. All CSF studies were negative for infectious causes. MRI revealed diffuse, symmetrical white matter abnormalities located in the occipital sub-cortex, thalamus, mid brain, pons, and cerebellum which were typical of CsA toxicity. The patient died of central respiratory failure within 72 h of discontinuing CsA. Autopsy revealed diffuse patchy white matter edema and astrocytic injury without evidence of axonopathy, demyelination, microvascular injury, or infectious/inflammatory process. This case demonstrates previously undescribed lethal CsA neurotoxicity and may reveal an associated primary pathological lesion.  (+info)

Molecular pathway involved in HIV-1-induced CNS pathology: role of viral regulatory protein, Tat. (5/1158)

The broad range of histological lesions associated with HIV-1 are somewhat subtle relative to the clinical manifestations that occur as a result of HIV infection. Although it is clear that HIV has a causative role in CNS disease, dementia appears to be a consequence of the infiltration of inflammatory cells and cytokine dysregulation rather than the amount of virus in CNS. The HIV transregulatory protein Tat plays an important intracellular as well as extracellular role in the dysregulation of cytokines. The cytokines and possibly chemokines that are induced by Tat modify the action of astrocytes such that the survival of neurons is compromised. Pathogenetic alteration induced by Tat involves a series of interactions between circulating monocyte/macrophages, endothelial cells, and astrocytes. Cytokine dysregulation induced by viral infection and extracellular Tat leads to alterations in expression of adhesion molecules and promotes migration of non-infected inflammatory cells into the CNS compartment. We demonstrate here that recombinant HIV-1 Tat protein introduced by stereotaxic injection into mouse brain can induce pathologically relevant alterations including macrophage invasion as well as astrocytosis. The mechanism of destruction of the CNS by Tat appears to involve autocrine and paracrine pathways that depend not only on Tat, but cytokine and chemokine signaling pathways that are altered by viral infection. In this review, we discuss various pathogenic effects of Tat in brain cells and provide experimental evidence for an increased TNF-alpha level in CSF in mice injected intracerebrally with Tat protein.  (+info)

Central nervous system sarcoidosis--diagnosis and management. (6/1158)

A series of 68 patients with neurosarcoidosis is reported, with particular emphasis on clinical aspects, diagnosis and treatment. A classification system based on clinical diagnostic probability is proposed, consisting of probable and definite disease, the latter being dependent on finding sarcoid granulomas on nervous system histology, which was obtained in 12 patients (18%). The role of investigations, including magnetic resonance imaging (MRI), chest radiography, Kveim skin test, Gallium 67 isotope scanning and cerebrospinal fluid (CSF) studies, is considered. Sixty-two percent of patients presented with nervous system disease, most commonly affecting the optic nerve and chiasm. Other common presentations included cranial nerve palsies, spinal cord and brainstem manifestations. Investigations yielding most diagnostic information included the Kveim test (41/48, 85% positive), raised CSF protein and/or cells (50/62, 81%) and gallium 67 scan (14/31, 45%). Eleven out of 29 patients (38%) patients showed meningeal enhancement on MRI scanning and 43% of scans demonstrated multiple white-matter lesions. Mean follow-up for the group was 4.6 years. Forty-seven patients were seen for > 18 months, and over half of these patients progressed despite corticosteroid and other immunosuppressive therapies. The benefit of a large patient database prospectively studied, with extended follow-up is discussed in order to learn more about prognosis and advance therapy in neurosarcoidosis.  (+info)

Complications of varicella in a defined central European population. (7/1158)

AIMS: To describe complications of varicella requiring hospitalisation in a defined population (canton of Bern) and to compare the hospitalisation rates for varicella with published data. METHODS: Retrospective analysis of hospital records of patients less than 16 years of age admitted with complications of varicella to the hospitals serving this population (University Children's Hospital of Bern and the Wildermeth Children's Hospital of Biel, Switzerland), and calculation of hospitalisation rates for varicella and its complications based on birth rates and varicella antibody prevalence rates. RESULTS: From 1986 to 1996, 113 cases (median age, 5.6 years) were identified. Younger siblings were overrepresented (odds ratio (OR), 1.42; 95% confidence interval (CI), 1.09 to 1.84). Central nervous system (CNS) complications (26 patients; 23%) were found predominantly in previously healthy children (relative risk, 7.1; 95% CI, 1.01 to 49.86). Group A beta haemolytic streptococci were recovered from only one of 35 patients with bacterial complications. The hospitalisation rates for primary varicella (9.2/10(4) cases; 95% CI, 7.4 to 11/10(4), skin infections (2.0/10(4) cases; 95% CI, 1.2 to 2.9/10(4), and pneumonia (0.8/10(4) cases; 95% CI, 0.3 to 1.3/10(4)) were significantly lower than reported previously. The CNS complication rate (2.2/10(4) cases; 95% CI, 1.3 to 3.1/10(4) was among the highest rates reported. CONCLUSIONS: The low hospitalisation rate in comparison with studies from elsewhere indicates that there is a large regional variability in complications associated with varicella. Such data should be taken into consideration when local varicella immunisation strategies are developed.  (+info)

C10 is a novel chemokine expressed in experimental inflammatory demyelinating disorders that promotes recruitment of macrophages to the central nervous system. (8/1158)

Chemokines may be important in the control of leukocytosis in inflammatory disorders of the central nervous system. We studied cerebral chemokine expression during the evolution of diverse neuroinflammatory disorders in transgenic mice with astrocyte glial fibrillary acidic protein-targeted expression of the cytokines IL-3, IL-6, or IFN-alpha and in mice with experimental autoimmune encephalomyelitis. Distinct chemokine gene expression patterns were observed in the different central nervous system inflammatory models that may determine the phenotype and perhaps the functions of the leukocytes that traffic into the brain. Notably, high expression of C10 and C10-related genes was found in the cerebellum and spinal cord of GFAP-IL3 mice with inflammatory demyelinating disease and in mice with experimental autoimmune encephalomyelitis. In both these neuroinflammatory models, C10 RNA and protein expressing cells were predominantly macrophage/microglia and foamy macrophages present within demyelinating lesions as well as in perivascular infiltrates and meninges. Intracerebroventricular injection of recombinant C10 protein promoted the recruitment of large numbers of Mac-1(+) cells and, to a much lesser extent, CD4(+) lymphocytes into the meninges, choroid plexus, ventricles, and parenchyma of the brain. Thus, C10 is a prominent chemokine expressed in the central nervous system in experimental inflammatory demyelinating disease that, we show, also acts as a potent chemotactic factor for the migration of these leukocytes to the brain.  (+info)

1. Neurodegenerative diseases: These are diseases that cause progressive loss of brain cells, leading to cognitive decline and motor dysfunction. Examples include Alzheimer's disease, Parkinson's disease, and Huntington's disease.
2. Stroke: A stroke occurs when blood flow to the brain is interrupted, leading to cell death and potential long-term disability.
3. Traumatic brain injury: This type of injury occurs when the brain is subjected to a sudden and forceful impact, such as in a car accident or fall.
4. Infections: Bacterial, viral, and fungal infections can all cause CNS diseases, such as meningitis and encephalitis.
5. Autoimmune disorders: These are conditions in which the immune system mistakenly attacks healthy cells in the brain, leading to inflammation and damage. Examples include multiple sclerosis and lupus.
6. Brain tumors: Tumors can occur in any part of the brain and can be benign or malignant.
7. Cerebrovascular diseases: These are conditions that affect the blood vessels in the brain, such as aneurysms and arteriovenous malformations (AVMs).
8. Neurodevelopmental disorders: These are conditions that affect the development of the brain and nervous system, such as autism spectrum disorder and attention deficit hyperactivity disorder (ADHD).

CNS diseases can have a significant impact on quality of life, and some can be fatal. Treatment options vary depending on the specific diagnosis and severity of the disease. Some CNS diseases can be managed with medication, while others may require surgery or other interventions.

Some common examples of CNSVD include:

1. Herpes simplex virus (HSV) encephalitis: This is an inflammation of the brain caused by the herpes simplex virus. It can cause fever, headache, confusion, and seizures.
2. West Nile virus (WNV) encephalitis: This is an infection of the brain caused by the West Nile virus, which is transmitted through the bite of an infected mosquito. Symptoms can include fever, headache, muscle weakness, and confusion.
3. Japanese encephalitis (JE): This is a viral infection that affects the brain and is transmitted through the bite of an infected mosquito. Symptoms can include fever, headache, seizures, and changes in behavior or cognitive function.
4. Rabies: This is a viral infection that affects the brain and is transmitted through the bite of an infected animal, usually a dog, bat, or raccoon. Symptoms can include fever, headache, agitation, and changes in behavior or cognitive function.
5. Enteroviral encephalitis: This is an infection of the brain caused by enteroviruses, which are common viruses that affect the gastrointestinal tract. Symptoms can include fever, vomiting, diarrhea, and changes in behavior or cognitive function.

The diagnosis of CNSVD typically involves a combination of physical examination, laboratory tests (such as blood tests or lumbar puncture), and imaging studies (such as CT or MRI scans). Treatment options vary depending on the specific disease and may include antiviral medications, supportive care, and rehabilitation.

Prevention of CNSVD includes avoiding exposure to mosquitoes and other vectors that can transmit disease, maintaining good hygiene practices (such as washing hands frequently), and getting vaccinated against diseases such as rabies and measles. In addition, taking steps to prevent head trauma and using protective equipment when engaging in activities that involve risk of head injury can help reduce the risk of CNSVD.

Overall, while central nervous system viral diseases can be serious and potentially life-threatening, early diagnosis and treatment can improve outcomes and prevent long-term complications. It is important to seek medical attention promptly if symptoms persist or worsen over time.

The symptoms of meningoencephalitis can vary depending on the cause, but common signs include fever, headache, stiff neck, confusion, seizures, and loss of consciousness. The disease can progress rapidly and can be fatal if not treated promptly.

Diagnosis is typically made through a combination of physical examination, laboratory tests (such as blood cultures and PCR), and imaging studies (such as CT or MRI scans). Treatment options depend on the underlying cause, but may include antibiotics, antiviral medications, and supportive care to manage symptoms and prevent complications.

Prognosis for meningoencephalitis depends on the severity of the disease and the promptness and effectiveness of treatment. In general, the prognosis is better for patients who receive prompt medical attention and have a mild form of the disease. However, the disease can be severe and potentially life-threatening, especially in young children, older adults, and those with weakened immune systems.

The most common types of CNS infections include:

1. Meningitis: Inflammation of the protective membranes (meninges) that cover the brain and spinal cord, often caused by bacteria or viruses.
2. Encephalitis: Inflammation of the brain tissue itself, usually caused by a virus.
3. Abscesses: Pockets of pus that form in the brain or spinal cord, typically caused by bacterial infections.
4. Cryptococcal infections: Caused by a fungus called Cryptococcus neoformans, often affecting people with weakened immune systems.
5. Toxoplasmosis: A parasitic infection caused by the Toxoplasma gondii parasite, which can affect the CNS in people with compromised immune systems.

Symptoms of CNS infections can vary depending on the specific type and severity of the infection, but may include fever, headache, confusion, seizures, weakness, and stiff neck. Diagnosis is typically made through a combination of physical examination, laboratory tests, and imaging studies such as CT or MRI scans.

Treatment of CNS infections depends on the underlying cause, but may involve antibiotics, antiviral medications, or antifungal drugs. In severe cases, hospitalization and supportive care such as intravenous fluids, oxygen therapy, and respiratory support may be necessary.

Prevention of CNS infections includes good hygiene practices such as frequent handwashing, avoiding close contact with people who are sick, and getting vaccinated against certain viruses that can cause CNS infections. Early diagnosis and prompt treatment are critical to preventing long-term complications of CNS infections and improving outcomes for patients.



Examples of Nervous System Diseases include:

1. Alzheimer's disease: A progressive neurological disorder that affects memory and cognitive function.
2. Parkinson's disease: A degenerative disorder that affects movement, balance and coordination.
3. Multiple sclerosis: An autoimmune disease that affects the protective covering of nerve fibers.
4. Stroke: A condition where blood flow to the brain is interrupted, leading to brain cell death.
5. Brain tumors: Abnormal growth of tissue in the brain.
6. Neuropathy: Damage to peripheral nerves that can cause pain, numbness and weakness in hands and feet.
7. Epilepsy: A disorder characterized by recurrent seizures.
8. Motor neuron disease: Diseases that affect the nerve cells responsible for controlling voluntary muscle movement.
9. Chronic pain syndrome: Persistent pain that lasts more than 3 months.
10. Neurodevelopmental disorders: Conditions such as autism, ADHD and learning disabilities that affect the development of the brain and nervous system.

These diseases can be caused by a variety of factors such as genetics, infections, injuries, toxins and ageing. Treatment options for Nervous System Diseases range from medications, surgery, rehabilitation therapy to lifestyle changes.

The word "SSPE" is an acronym for the disease name. It stands for "Subacute Sclerosing Panencephalitis."

Some common types of brain diseases include:

1. Neurodegenerative diseases: These are progressive conditions that damage or kill brain cells over time, leading to memory loss, cognitive decline, and movement disorders. Examples include Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS).
2. Stroke: This occurs when blood flow to the brain is interrupted, leading to cell death and potential long-term disability.
3. Traumatic brain injury (TBI): This refers to any type of head injury that causes damage to the brain, such as concussions, contusions, or penetrating wounds.
4. Infections: Viral, bacterial, and fungal infections can all affect the brain, leading to a range of symptoms including fever, seizures, and meningitis.
5. Tumors: Brain tumors can be benign or malignant and can cause a variety of symptoms depending on their location and size.
6. Cerebrovascular diseases: These conditions affect the blood vessels of the brain, leading to conditions such as aneurysms, arteriovenous malformations (AVMs), and Moyamoya disease.
7. Neurodevelopmental disorders: These are conditions that affect the development of the brain and nervous system, such as autism spectrum disorder, ADHD, and intellectual disability.
8. Sleep disorders: Conditions such as insomnia, narcolepsy, and sleep apnea can all have a significant impact on brain function.
9. Psychiatric disorders: Mental health conditions such as depression, anxiety, and schizophrenia can affect the brain and its functioning.
10. Neurodegenerative with brain iron accumulation: Conditions such as Parkinson's disease, Alzheimer's disease, and Huntington's disease are characterized by the accumulation of abnormal proteins and other substances in the brain, leading to progressive loss of brain function over time.

It is important to note that this is not an exhaustive list and there may be other conditions or factors that can affect the brain and its functioning. Additionally, many of these conditions can have a significant impact on a person's quality of life, and it is important to seek medical attention if symptoms persist or worsen over time.

The exact cause of ADC is not fully understood, but it is believed to be related to the progression of HIV infection in the brain. As HIV replicates in the brain, it can damage brain cells and disrupt normal brain function.

ADC typically affects individuals who have advanced HIV infection and a low CD4 cell count (a measure of immune system health). It is more common in women than men and tends to occur at an older age.

There are several symptoms of ADC, including:

1. Cognitive impairment: difficulty with memory, concentration, and decision-making.
2. Changes in personality and behavior: depression, anxiety, and agitation.
3. Difficulty with speech and language: slurred speech, trouble finding the right words.
4. Coordination and balance problems: unsteadiness, tremors, and difficulty with movement.
5. Seizures: ADC can cause seizures, which can be a sign of a more severe form of the disorder.

There is no cure for ADC, but treatment can help manage its symptoms and slow its progression. Treatment typically involves a combination of antiretroviral therapy (ART) to suppress HIV replication, and medications to manage cognitive and behavioral symptoms. In addition, supportive care, such as physical therapy and occupational therapy, can help improve quality of life.

In conclusion, AIDS Dementia Complex (ADC) is a serious neurological disorder that affects individuals with advanced HIV infection. It is characterized by cognitive impairment, changes in personality and behavior, and difficulty with speech and movement. While there is no cure for ADC, treatment can help manage its symptoms and slow its progression.

The most common demyelinating diseases include:

1. Multiple sclerosis (MS): An autoimmune disease that affects the CNS, including the brain, spinal cord, and optic nerves. MS causes inflammation and damage to the myelin sheath, leading to a range of symptoms such as muscle weakness, vision problems, and cognitive difficulties.
2. Acute demyelination: A sudden, severe loss of myelin that can be caused by infections, autoimmune disorders, or other factors. This condition can result in temporary or permanent nerve damage.
3. Chronic inflammatory demyelination (CIDP): A rare autoimmune disorder that causes progressive damage to the myelin sheath over time. CIDP can affect the CNS and the peripheral nervous system (PNS).
4. Moore's disease: A rare genetic disorder that results in progressive demyelination of the CNS, leading to a range of neurological symptoms including muscle weakness, seizures, and cognitive difficulties.
5. Leukodystrophies: A group of genetic disorders that affect the development or function of myelin-producing cells in the CNS. These conditions can cause progressive loss of myelin and result in a range of neurological symptoms.

Demyelinating diseases can be challenging to diagnose, as the symptoms can be similar to other conditions and the disease progression can be unpredictable. Treatment options vary depending on the specific condition and its severity, and may include medications to reduce inflammation and modulate the immune system, as well as rehabilitation therapies to help manage symptoms and improve quality of life.

The most common symptoms of enterovirus infections include:

* Diarrhea
* Vomiting
* Fever
* Abdominal pain
* Headache
* Fatigue

In some cases, enterovirus infections can lead to more severe complications, such as:

* Hand, foot, and mouth disease (HFMD)
* Aseptic meningitis
* Encephalitis
* Myocarditis

Enteroviruses are highly contagious and can be spread through:

* Close contact with an infected person
* Contaminated food and water
* Insect vectors

There is no specific treatment for enterovirus infections, but symptoms can be managed with supportive care, such as hydration, rest, and pain relief. Antiviral medications may be used in severe cases.

Prevention measures include:

* Good hygiene practices, such as frequent handwashing
* Avoiding close contact with people who are sick
* Properly preparing and storing food and water
* Avoiding sharing items that come into contact with the mouth, such as utensils and drinking glasses.

1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.

2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.

3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.

4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.

5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.

6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.

7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.

8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.

9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.

10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.

Benign CNS neoplasms include:

1. Meningiomas: These are the most common type of benign CNS tumor, arising from the meninges (the membranes covering the brain and spinal cord).
2. Acoustic neuromas: These tumors arise from the nerve cells that connect the inner ear to the brain.
3. Pineal gland tumors: These are rare tumors that occur in the pineal gland, a small gland located in the brain.
4. Craniopharyngiomas: These are rare tumors that arise from the remnants of the embryonic pituitary gland and can cause a variety of symptoms including headaches, vision loss, and hormonal imbalances.

Malignant CNS neoplasms include:

1. Gliomas: These are the most common type of malignant CNS tumor and arise from the supporting cells of the brain called glial cells. Examples of gliomas include astrocytomas, oligodendrogliomas, and medulloblastomas.
2. Lymphomas: These are cancers of the immune system that can occur in the CNS.
3. Melanomas: These are rare tumors that arise from the pigment-producing cells of the skin and can spread to other parts of the body, including the CNS.
4. Metastatic tumors: These are tumors that have spread to the CNS from other parts of the body, such as the breast, lung, or colon.

The diagnosis and treatment of central nervous system neoplasms depend on the type, size, location, and severity of the tumor, as well as the patient's overall health and medical history. Treatment options can include surgery, radiation therapy, chemotherapy, targeted therapy, and immunotherapy.

The prognosis for CNS neoplasms varies depending on the type of tumor and the effectiveness of treatment. In general, gliomas have a poorer prognosis than other types of CNS tumors, with five-year survival rates ranging from 30% to 60%. Lymphomas and melanomas have better prognoses, with five-year survival rates of up to 80%. Metastatic tumors have a more guarded prognosis, with five-year survival rates depending on the primary site of the cancer.

In summary, central nervous system neoplasms are abnormal growths of tissue in the brain and spinal cord that can cause a variety of symptoms and can be benign or malignant. The diagnosis and treatment of these tumors depend on the type, size, location, and severity of the tumor, as well as the patient's overall health and medical history. The prognosis for CNS neoplasms varies depending on the type of tumor and the effectiveness of treatment, but in general, gliomas have a poorer prognosis than other types of CNS tumors.

There are many different types of ANS diseases, including:

1. Dysautonomia: a general term that refers to dysfunction of the autonomic nervous system.
2. Postural orthostatic tachycardia syndrome (POTS): a condition characterized by rapid heart rate and other symptoms that occur upon standing.
3. Neurocardiogenic syncope: a form of fainting caused by a sudden drop in blood pressure.
4. Multiple system atrophy (MSA): a progressive neurodegenerative disorder that affects the autonomic nervous system and other parts of the brain.
5. Parkinson's disease: a neurodegenerative disorder that can cause autonomic dysfunction, including constipation, urinary incontinence, and erectile dysfunction.
6. Dopamine deficiency: a condition characterized by low levels of the neurotransmitter dopamine, which can affect the ANS and other body systems.
7. Autonomic nervous system disorders associated with autoimmune diseases, such as Guillain-Barré syndrome and lupus.
8. Trauma: physical or emotional trauma can sometimes cause dysfunction of the autonomic nervous system.
9. Infections: certain infections, such as Lyme disease, can affect the autonomic nervous system.
10. Genetic mutations: some genetic mutations can affect the functioning of the autonomic nervous system.

Treatment for ANS diseases depends on the specific condition and its underlying cause. In some cases, medication may be prescribed to regulate heart rate, blood pressure, or other bodily functions. Lifestyle changes, such as regular exercise and stress management techniques, can also be helpful in managing symptoms. In severe cases, surgery may be necessary to correct anatomical abnormalities or repair damaged nerves.

Some common examples of digestive system diseases include:

1. Irritable Bowel Syndrome (IBS): This is a chronic condition characterized by abdominal pain, bloating, and changes in bowel habits such as constipation or diarrhea.
2. Inflammatory Bowel Disease (IBD): This includes conditions such as Crohn's disease and ulcerative colitis, which cause chronic inflammation in the digestive tract.
3. Gastroesophageal Reflux Disease (GERD): This is a condition where stomach acid flows back up into the esophagus, causing heartburn and other symptoms.
4. Peptic Ulcer: This is a sore on the lining of the stomach or duodenum (the first part of the small intestine) that can cause pain, nausea, and vomiting.
5. Diverticulosis: This is a condition where small pouches form in the wall of the colon, which can become inflamed and cause symptoms such as abdominal pain and changes in bowel habits.
6. Constipation: This is a common condition where the stool is hard and difficult to pass, which can be caused by a variety of factors such as poor diet, dehydration, or certain medications.
7. Diabetes: This is a chronic condition that affects how the body regulates blood sugar levels, which can also affect the digestive system and cause symptoms such as nausea, vomiting, and abdominal pain.
8. Celiac Disease: This is an autoimmune disorder where the immune system reacts to gluten, a protein found in wheat, barley, and rye, causing inflammation and damage to the small intestine.
9. Lipidosis: This is a condition where there is an abnormal accumulation of fat in the body, which can cause symptoms such as abdominal pain, nausea, and vomiting.
10. Sarcoidosis: This is a chronic inflammatory disease that can affect various organs in the body, including the digestive system, causing symptoms such as abdominal pain, diarrhea, and weight loss.

It's important to note that this list is not exhaustive and there are many other conditions that can cause abdominal pain. If you are experiencing persistent or severe abdominal pain, it's important to seek medical attention to determine the underlying cause and receive proper treatment.

Peripheral Nervous System Diseases can result from a variety of causes, including:

1. Trauma or injury
2. Infections such as Lyme disease or HIV
3. Autoimmune disorders such as Guillain-Barré syndrome
4. Genetic mutations
5. Tumors or cysts
6. Toxins or poisoning
7. Vitamin deficiencies
8. Chronic diseases such as diabetes or alcoholism

Some common Peripheral Nervous System Diseases include:

1. Neuropathy - damage to the nerves that can cause pain, numbness, and weakness in the affected areas.
2. Multiple Sclerosis (MS) - an autoimmune disease that affects the CNS and PNS, causing a range of symptoms including numbness, weakness, and vision problems.
3. Peripheral Neuropathy - damage to the nerves that can cause pain, numbness, and weakness in the affected areas.
4. Guillain-Barré syndrome - an autoimmune disorder that causes muscle weakness and paralysis.
5. Charcot-Marie-Tooth disease - a group of inherited disorders that affect the nerves in the feet and legs, leading to muscle weakness and wasting.
6. Friedreich's ataxia - an inherited disorder that affects the nerves in the spine and limbs, leading to coordination problems and muscle weakness.
7. Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - an autoimmune disorder that causes inflammation of the nerves, leading to pain, numbness, and weakness in the affected areas.
8. Amyotrophic Lateral Sclerosis (ALS) - a progressive neurological disease that affects the nerve cells responsible for controlling voluntary muscle movement, leading to muscle weakness, atrophy, and paralysis.
9. Spinal Muscular Atrophy - an inherited disorder that affects the nerve cells responsible for controlling voluntary muscle movement, leading to muscle weakness and wasting.
10. Muscular Dystrophy - a group of inherited disorders that affect the nerve cells responsible for controlling voluntary muscle movement, leading to muscle weakness and wasting.

It's important to note that this is not an exhaustive list and there may be other causes of muscle weakness. If you are experiencing persistent or severe muscle weakness, it is important to see a healthcare professional for proper evaluation and diagnosis.

The exact cause of CNS vasculitis is not fully understood, but it is believed to be an autoimmune disorder, meaning that the immune system mistakenly attacks healthy tissues in the CNS. The condition can occur at any age, but it most commonly affects adults between the ages of 40 and 60.

Symptoms of CNS vasculitis can vary depending on the location and severity of the inflammation, but may include:

* Headaches
* Confusion
* Memory loss
* Seizures
* Weakness or numbness in the limbs
* Vision problems
* Speech difficulties

Diagnosis of CNS vasculitis typically involves a combination of physical examination, medical history, and diagnostic tests such as MRI or CT scans, lumbar puncture, and blood tests. Treatment options for CNS vasculitis vary depending on the severity of the condition and may include corticosteroids, immunosuppressive drugs, and plasmapheresis. In severe cases, surgery may be necessary to relieve pressure on the brain or spinal cord.

Overall, CNS vasculitis is a serious condition that can have significant neurological consequences if left untreated. Early diagnosis and aggressive treatment are critical to prevent long-term damage and improve outcomes for patients with this condition.

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A common disease to the central nervous system is multiple sclerosis. In this disease, the immune system attacks the myelin ... Damage to the peripheral nervous system or central nervous system can result in a decline or loss of pallesthesia. A diminished ... It can help to identify effects of other diseases on the nervous system, such as diabetes mellitus. The peripheral nervous ... The central nervous system is composed of the spinal cord and the brain. Many neurological studies are conducted on patients ...
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It affects people with heart disease and the central nervous system. Sulfur oxides are the cause of acid rain that damages the ... The U.S. has an extensive system of highways, including the National Highway System begun in the early 20th century and the ... "Intelligent Transportation Systems - Congestion Initiative". U.S. Department of Transportation. Archived from the original on ... It particularly aggravates heart and lung diseases in children and the elderly. Nitrogen oxides are the main ingredients in the ...
Many proteins and RNA biomarkers identified are connected to ischemic stroke pathophysiology includes Central Nervous System ... Moyamoya disease has also been identified as a potential cause for brain ischemia. Moyamoya disease is an extremely rare ... Brain ischemia has been linked to a variety of diseases or abnormalities. Individuals with sickle cell anemia, compressed blood ... Sparks, Gareth (2002). "What is Moyamoya disease?". eSSORTMENT. Archived from the original on 2009-03-27. Retrieved 2009-04-13 ...
... the central nervous system and, in men, the testes and semen. Cafferkey went to a 24-hour GP clinic in New Victoria Hospital in ... "Study of Ebola Virus Disease Survivors in Guinea: Table 1". Clinical Infectious Diseases. 61 (7): 1035-1042. doi:10.1093/cid/ ... the virus had remained in her cerebrospinal fluid and feared that it might be in her central nervous system. Personnel in ... The prognosis after recovery from Ebola virus disease can include joint pains, muscular pain, skin peeling, or hair loss. In a ...
This suggests a possible systemic component of this disease, despite the predominance of central nervous system features. The ... Autoimmune diseases, Neurological disorders, Vascular diseases, Rare syndromes, Syndromes affecting the nervous system). ... Susac's syndrome is a very rare disease, of unknown cause, and many persons who experience it do not display the bizarre ... Despite this being an extremely rare disease, there are 4 registries collecting data on the illness; two are the United States ...
Rare diseases, Neurodegenerative disorders, Peripheral nervous system disorders). ... can be explained as cell loss and gliosis or a proliferation of astrocytes in damaged areas of the central nervous system. This ... Parkinson's disease and multiple system atrophy, being the first process to give an objective diagnosis of Multiple System ... The region in question includes the SHC2 gene which, in mice and rats, appears to have some function in the nervous system. The ...
"The Orotomide Olorofim Is Efficacious in an Experimental Model of Central Nervous System Coccidioidomycosis". Antimicrobial ... New Opportunities for Treatment of Multidrug-Resistant Fungal Disease". mBio. 8 (4). e01157-17. doi:10.1128/mBio.01157-17. PMC ... The Journal of Infectious Diseases. 217 (7): 1118-1127. doi:10.1093/infdis/jix479. PMC 5909626. PMID 28968675. (Antifungals, ...
Papillary tumors of the central nervous system and particularly of the pineal region are very rare and so diagnosing them is ... The value of radiotherapy as well as chemotherapy on disease progression will need to be investigated in future trials. With ... WHO classification of tumours of the central nervous system, chapter 7, Eds: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, IARC ... Papillary tumors of pineal region are extremely rare, constituting 0.4-1% of all central nervous system tumors. These tumors ...
Axons in the central nervous system do not regenerate after injury the same way that axons in the peripheral nervous system do ... Mutations to the MAG gene are implicated in demyelination diseases such as multiple sclerosis. ... Lopez PH (2014). "Role of myelin-associated glycoprotein (siglec-4a) in the nervous system". Advances in Neurobiology. 9: 245- ... Lopez PH (2014). "Role of myelin-associated glycoprotein (siglec-4a) in the nervous system". Advances in Neurobiology. 9: 245- ...
... severe manifestations of this disease may involve the respiratory system, central nervous system, gastrointestinal system, or ... "Tickborne Rickettsial Diseases". Rocky Mountain Spotted Fever. Centers for Disease Control. 2018-10-26. Dantas-Torres, Filipe ( ... the elaborate biocontainment systems of today had not been invented. Research into this disease in Montana is a sub-plot of the ... of rickettsial diseases. "Delay in treatment of rickettsial diseases may lead to severe illness or death. Children are five ...
The researchers were interested in studying how the nervous system recovered during arm regeneration as this could have ... Amphiura filiformis has a central disc up to 10 mm (0.4 in) in diameter and five slender arms up to 100 mm (4 in) long. The ... applications for understanding and treating neurodegenerative diseases in humans. Stöhr, Sabine (2012). "Amphiura filiformis (O ...
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v t e (Central nervous system disorders, Myelin disorders, All stub articles, Nervous system disease stubs). ... Meningococcal myelitis is a disorder of the myelin sheath, which is a primary actor in the central nervous system. It has been ... "Vaccine-preventable disease control in the People's Republic of China: 1949-2016". Vaccine. 36 (52): 8131-8137. doi:10.1016/j. ...
TTC39B is well expressed in muscles, internal organs, secretory organs, reproductive organs, the immune system, and the nervous ... Isoform 2 uses an alternate in-frame splice site in the central coding region, compared to variant 1, which results in a ... TTC39A has been tested for association to diseases like breast neoplasms and is expected to have molecular binding function and ... Isoform 3 and 4 have multiple differences in the central coding region but maintain the reading frame compared to isoform 1. ...
It selectively targets neuroblasts in the central nervous system. In rats, administration of MAM affects structures in the ... is a neurotoxin which reduces DNA synthesis used in making animal models of neurological diseases including schizophrenia and ...
ISBN 978-0-19-954089-1. Who's Who of Rhodesia, Mauritius, Central and East Africa: Supplement to the Who's Who of Southern ... ISBN 978-0-19-954088-4. "BBC News - Don Broco 'nervous' about double festivals date". BBC News. Retrieved 29 January 2015. " ... systems engineer, author and expert on survivor guilt Professor John Richard Anthony Pearson FRS FIMMM MIChemE (born 1930), ... Surgeon to the Hospital for Diseases of the Throat, Golden Square". WHO'S WHO & WHO WAS WHO. 2007. doi:10.1093/ww/ ...
Olson JK, Miller SD (September 2004). "Microglia initiate central nervous system innate and adaptive immune responses through ... Disease. Increased occurrence of asthma in some populations may be associated with Ser249Pro polymorphism, also present in the ... disease". Genes and Immunity. 14 (7): 420-6. doi:10.1038/gene.2013.34. PMC 3791179. PMID 23823019. Lien E, Ingalls RR (January ... "Toll-like receptor polymorphism in host immune response to infectious diseases: A review". Scandinavian Journal of Immunology. ...
... brain and central nervous system, immune, skeletal, and reproductive systems. Zinc deficiency in humans is caused by reduced ... Wilson's disease, sickle cell disease, chronic kidney disease, chronic liver disease have all been associated with zinc ... This phenomenon is central to the high risk of zinc deficiency worldwide. Soil zinc is an essential micronutrient for crops. ... Central Anatolia, in Turkey, was a region with zinc-deficient soils and widespread zinc deficiency in humans. In 1993, a ...
Coniine acts directly on the central nervous system through inhibitory action on nicotinic acetylcholine receptors. In high ... Avian Diseases. 34 (2): 433-437. doi:10.2307/1591432. JSTOR 1591432. PMID 2369382. Blamey, M.; Fitter, R.; Fitter, A. (2003). ...
The People and Hospitals that Became Appalachian Regional Healthcare System'". Appalachian Regional Healthcare System. 21 ... The house was four stories and divided into a central section with two wings, each attached to the main house at a 20 degree ... In the deposition of the divorce, Cannon reported that Reynolds would curse at her and made her feel "terribly nervous and ... foundation's first grant in 1937 went towards the North Carolina State Health Department's activities to treat venereal disease ...
Cennamo-Gangemi syndrome Central core disease Central diabetes insipidus Central nervous system protozoal infections Central ... Marie-Tooth disease type 1A Charcot-Marie-Tooth disease type 1B Charcot-Marie-Tooth disease type 1C Charcot-Marie-Tooth disease ... Marie-Tooth disease type 2C Charcot-Marie-Tooth disease type 2D Charcot-Marie-Tooth disease type 4A Charcot-Marie-Tooth disease ... Tooth disease Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease deafness dominant type Charcot-Marie-Tooth disease ...
Rachael Maskell York Central MP said Andrew was the "first to ever have their freedom removed". There have also been calls to ... "Prince Andrew's 'nervous' move after Ghislaine Maxwell's arrest". NewsComAu. 6 July 2020. Retrieved 13 September 2021. Casciani ... "gaming the system" and should not have won as "he may have used bots - autonomous internet programs - to boost his vote". ... a charity dedicated to research into the prevention and treatment of blindness and eye disease, and was a member of the Scout ...
In 2004, Macklis founded the Neuroscience / Nervous System Diseases Program at the Harvard Stem Cell Institute at Harvard ... and corticobasal degeneration The Macklis lab studies mechanisms of endogenous regeneration in the central nervous system which ... Nervous System Diseases Program at the Harvard Stem Cell Institute. Macklis received a dual S.B. in bioelectrical engineering ... where he was the founding Director of the MGH-HMS Center for Nervous System Repair (2002-2011). He also co-directed the ...
... culminating in Brătianu's arrival to power after the premier fell victim to a nervous disease -, Stere replaced Petre Poni at ... One of the central figures of the Bessarabian intelligentsia at the time, Stere was a key actor during the Union of Bessarabia ... in Journal of World Systems Research, XI, 1, July 2005, p. 3-26 Ion Coman, "Un pretext, un şantaj, o mostră a politicianismului ... At the time, a physician who examined him noted that he had suffered a nervous breakdown, and had him moved to a prison ...
The virus is not detected in the central nervous system (CNS) of the majority of COVID-19 patients with neurological issues. ... Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a virus, the severe acute respiratory syndrome ... The cells of the central nervous system, the microglia, neurons, and astrocytes, are also involved in the release of pro- ... The involvement of both the central and peripheral nervous system in COVID‑19 has been reported in many medical publications. ...
Within the Central Nervous System (CNS), nerve cell bodies are generally organized into functional clusters, called nuclei. ... Spinal cord injury can also be non-traumatic and caused by disease (transverse myelitis, polio, spina bifida, Friedreich's ... The brain and spinal cord together make up the central nervous system (CNS). In humans, the spinal cord begins at the occipital ... "Radial glia and neural progenitors in the adult zebrafish central nervous system". Glia. 63 (8): 1406-1428. doi:10.1002/glia. ...
... kidney or liver disease, active Central nervous system (CNS) metastases, active systemic autoimmune disease, interstitial lung ... This allows the immune system to target and destroy cancer cells, but also blocks a key mechanism preventing the immune system ... It is an IgG4 isotype antibody that blocks a protective mechanism of cancer cells and thereby, allows the immune system to ... This receptor is generally responsible for preventing the immune system from attacking the body's own tissues; it is a so- ...
... the fall of Napoleon and the contraction of a mysterious disease affecting his nervous system which left him paralyzed from the ... the year in which two central occurrences took place in his life: ... When he was a guest of Giorgetti's in Florence, Rossini was at the mercy of his depression and nervous crises, which Giorgetti ...
... out of the empire's control system and into a new democratic model", a stable democratic system which has lasted to the present ... Central to long-term peasant grievances were the loss of communal lands, forest restrictions (such as the French Forest Code of ... Many unskilled laborers toiled from 12 to 15 hours per day when they had work, living in squalid, disease-ridden slums. ... The Revolutions of 1848 were followed by new centrist coalitions dominated by liberals nervous of the threat of working-class ...
These cells respond to signals from the autonomic nervous system to either increase or decrease the heart rate. Pacemaker cells ... Coronary artery disease (narrowed coronary arteries) Arrhythmia (irregular heartbeat) Cardiomyopathy (disease of the heart ... Cardiac muscle cells generally only contain one nucleus, located in the central region. They contain many mitochondria and ...
... central nervous system, liver, kidneys, adrenal, bones, and lungs. If ingestion of calcium and alkali is continued, neurologic ... Underlying kidney disease is a risk factor for MAS, but even people with healthy kidneys can develop the syndrome. For a ... In the early years after the discovery of milk-alkali syndrome, the prevalence of the disease among people treated with Sippy's ... Increasing education in both people and clinicians surrounding milk-alkali syndrome can help prevent the disease. Over recent ...
... s are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where ... "Histamine H3 Receptor as a Potential Target for Cognitive Symptoms in Neuropsychiatric Diseases." Behavioural Brain Research ... Central nervous system Peripheral nervous system Heart Lungs Gastrointestinal tract Endothelial cells Like all histamine ... because it is linked to the central nervous system and its regulation of other neurotransmitters. Examples of such disorders ...
Raccoon Roundworm Infection Associated with Central Nervous System Disease and Ocular Disease - Six States, 2013-2015. Weekly ... Raccoon Roundworm Infection Associated with Central Nervous System Disease and Ocular Disease - Six States, 2013-2015. MMWR ... including six cases of central nervous system disease and one of ocular disease. Laboratory and clinical information for each ... which is often found in Baylisascaris procyonis central nervous system disease (8). In the single case of ocular larva migrans ...
Diagnostic Challenges of Central Nervous System Tuberculosis. Emerging Infectious Diseases. 2008;14(9):1473-1475. doi:10.3201/ ... Tuberculosis of the central nervous system. Postgrad Med J. 1999;75:133-40.PubMedGoogle Scholar ... Central nervous system tuberculosis (TB) was identified in 20 cases of unexplained encephalitis referred to the California ... Tuberculosis (TB) of the central nervous system (CNS) is classically described as meningitis. However, altered mental status, ...
19/04/2011 - Masitinib as an adjunct therapy for mild-tomoderate Alzheimers disease: a randomised, placebo-controlled phase 2 ...
Central nervous system diseases are characterized by slow onset, occultation, a... ... thus participating in the occurrence and development of various central nervous system diseases, such as Parkinsons disease ( ... α-Syn is associated with other central nervous system diseases. The association between α-syn and PD has been studied ... which participate in the occurrence and development of various central nervous system diseases, including Parkinsons disease ( ...
Pediatric central nervous system infections and inflammatory white matter disease. Pediatr Clin North Am. 2005 Aug; 52(4):1107- ... Pediatric central nervous system infections and inflammatory white matter disease.. *See All Pages ...
Results of search for su:{Central nervous system diseases} Refine your search. *. Availability. * Limit to currently ... Novel infectious agents and the central nervous system. Series: Ciba Foundation symposium ; 135Material type: Text; Format: ... Histological typing of tumours of the central nervous system / P. Kleihues, P. C. Burger, and B. W. Scheithauer, in ... Virus infections and the developing nervous system / edited by R. T. Johnson and G. Lyon. by Johnson, Richard Tidball , Lyon, ...
Did you know that some vaccines have been associated with demyelinating diseases of the central nervous system? ... "The most commonly reported vaccinations that have been associated with CNS (central nervous system) demyelinating diseases ...
Brain Diseases, Metabolic, Inborn. Brain Diseases, Metabolic. Brain Diseases. Central Nervous System Diseases. Nervous System ... Fabry Disease. Sphingolipidoses. Lysosomal Storage Diseases, Nervous System. ... Cerebral Small Vessel Diseases. Cerebrovascular Disorders. Vascular Diseases. Cardiovascular Diseases. Genetic Diseases, X- ... Genetic and Rare Diseases Information Center resources: Fabry Disease Sphingolipidosis U.S. FDA: Expanded Access (Compassionate ...
Huntington Disease. Basal Ganglia Diseases. Brain Diseases. Central Nervous System Diseases. Nervous System Diseases. Dementia ... Heredodegenerative Disorders, Nervous System. Neurodegenerative Diseases. Genetic Diseases, Inborn. Cognition Disorders. ... Condition or disease Intervention/treatment Phase Huntingtons Disease Genetic: intra-striatal rAAV5-miHTT Other: Imitation ( ... MedlinePlus related topics: Huntington's Disease Genetic and Rare Diseases Information Center resources: Huntington ...
Central Autonomic Nervous System Diseases; Disorders of the Autonomic Nervous System; Nervous System Diseases, Autonomic; ... Parasympathetic Nervous System Diseases; Peripheral Autonomic Nervous System Diseases; Sympathetic Nervous System Diseases. On- ... Nervous System Diseases, Parasympathetic; Nervous System Diseases, Sympathetic; ... Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms ...
New Series to Launch: Alzheimers Disease and the Central Nervous System. According to a report from the Alzheimers Foundation ... Alzheimers disease ranks as one of the toughest nuts to crack within drug discovery and development. Current treatments merely ... President Nixon made fighting this disease a priority in his 1971 State of the Union address: "I will also ask for an ... Patient Agitation in Alzheimers Disease: Implications for Patients and Caregivers. Real World Health Care recently sat down ...
... central nervous system complications; central nervous system graft-versus-host disease; graft-versus-host disease ... Central Nervous System-related Graft-versus-host Disease after Allogeneic Hematopoietic Stem Cell Transplantation. ... Central Nervous System-related Graft-versus-host Disease after Allogeneic Hematopoietic St ... and infectious diseases. Furthermore, there are many unclear points regarding central nervous system (CNS) complications, and ...
Peripheral nervous system (PNS) is a term referring to the nerves that lie outside of the central nervous system (brain and ... A nerve cell used to transmit information within the central nervous system. Parkinsons disease involves death of and/or ... of certain brain systems in conditions such as Parkinsons disease, Alzheimers disease and Lou Gehrigs disease (ALS). ... A thin layer of tightly packed cells separating the central nervous system from the bodys blood stream. This layer is crucial ...
... is a fungal infection endemic to South and Central America, most notably Brazil, Argentina, Colombia, and Venezuela (see the ... formerly known as South American blastomycosis and Lutz-Splendore-Almeida disease, ... Central nervous system involvement - Meningitis and parenchymal granulomatous disease; observed in 5-25% of patients; can cause ... Central nervous system paracoccidioidomycosis: clinical features and laboratorial findings. J Infect. 2004 Feb. 48(2):193-8. [ ...
... others as a disease of the peripheral nervous system; others as a disease of the central nervous system". They further wrote ... cramp is a disease of the central nervous system, and is the result of a weakening or breakdown of the cerebral controlling ... nervous system, kidney, bladder and haematological disease), as well as cancer, allergies, regular medication use, and a ... Underlying chronic disease, medication use, history of running injuries and being a more experienced runner are independent ...
disease of anatomical entity. 18156. nervous system disease. 13996. central nervous system disease. 12287. ... Diseases Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes ... Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory ... RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically ...
Alcoholic Intoxication; Alcoholism; Amino Acids; Carbohydrates; Central Nervous System Diseases; Fatty Acids; Mathematical ... Diabetes Mellitus - Type 1; Diseases of the Endocrine System; Diseases of the Nervous System. Impact of Hypoglycemia on Brain ... Diseases of the Nervous System; Mental Health & Behavioral Research. Biomarkers of Clinical Subtype and Treatment Response in ... Diseases of the Nervous System; Mental Health & Behavioral Research. Examination of Glutamate and mGluR5 in Psychiatric ...
CDC WONDER is a system for disseminating Public Health data and information ... Diseases of Central Nervous system , Encephalitis , Encephalomyelitis , Epilepsy , Mastoiditis , Menieres disease , Meningitis ... disease, cerebrovascular disease, arteriosclerosis, other diseases of the circulating system ... Other disease of the circulatory system Aortic aneurysm Arterial embolism and thrombosis Buergers disease Chilblains ...
MS is a chronic autoimmune inflammatory disease of the central nervous system.3 It affects more than 700,000 people in Europe, ... 5 Gitto L. Multiple Sclerosis patients awareness of disease and compliance to pharmacological treatment with Disease Modifying ... Poster Presentation Shares New Data on the Symptoms and Impacts of Fatigue Using a New Disease-Specific Scale1 ... United in our collective power to do something about MS now and end this disease forever. The gathering place for people with ...
Look up free coding details for ICD-10 code range G00-G99 that cover Diseases of the nervous system. ... Inflammatory diseases of the central nervous system. *G00 Bacterial meningitis, not elsewhere clas... ... Diseases of the eye and adnexa. *H00-H05 Disorders of eyelid, lacrimal system and... ... Polyneuropathies and other disorders of the peripheral nervous system. Type 1 Excludes*neuralgia NOS (M79.2) ...
Central Nervous System Diseases. en. dc.subject.mesh. Peripheral Nervous System Diseases. en. ... Control of brain and nerve diseases : a world-wide challenge. en. dc.title.alternative. Un défi au monde entier : la lutte ... Control of brain and nerve diseases : a world-wide challenge. dc.contributor.author. World Health Organization. en. ... contre les maladies du système nerveux central et périphérique. en. ...
Skin-diseases; Central-nervous-system-disorders; Bladder-cancer; Bladder-disorders; Bladder-disease; Gastrointestinal-system- ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ...
... ingredients in modulating inflammation associated with the development and/or progression of central nervous system diseases. ... Due to the dynamic progress of diseases such as Alzheimers disease (AD), Parkinsons Disease (PD), Schizophrenia, Depression, ... which play a critical role in the pathogenesis of various neurological diseases and dietary interventions, such as the ... create a positive brain environment and is associated with a reduced risk of neurological diseases. Personalized nutritional ...
Multiple sclerosis is a long-term disease that attacks the central nervous system. Learn more about MS here. ... In learning how the nervous system and cells are damaged in MS, scientists have used their findings to investigate therapies ... Researchers are making headway in testing approaches that protect the nervous system from MS-related damage. These strategies ... Training with weights may help to protect the nervous systems and slow MS progression.. ...
The human form of mad cow disease, vCJD, attacks the central nervous system ... how did the disease cross species to infect humans as vCJD and what factors affect whether a human will contract the disease. ... The BSE disease can be particularly concentrated in cow brains, spinal cords and certain organs such as the spleen. ... White blood cells, which form part of the immune system and are found in the lymph glands, were isolated as one of the high- ...
It is a type of brain disease called leukodystrophy. ... Krabbe disease is a rare genetic disorder of the nervous system ... This disease damages the central nervous system. It can cause:. *Blindness. *Deafness ... Krabbe disease is a rare genetic disorder of the nervous system. It is a type of brain disease called leukodystrophy. ... People who develop the disease at a later age have survived into adulthood with nervous system disease. ...
Central Nervous System Diseases. Treatment:. Surgery is used to correct the dog stomach blockage or obstruction. Sudden ... The disease causes enlarged (hypertrophic) mucosa (membrane that lines the stomach) and the circular smooth muscle. ... Conditions that block the digestive system and causes a dog stomach blockage includes ulcers and gastritis. Other causes ... Neoplasia: (rare in dogs). Neoplasia are tumors that grow and obstruct the gastrointestinal system. ...
Herein we will review advances in the understanding of the role of several proteins of the UPS in Alzheimers disease (AD) and ... Herein, we will review advances in the understanding of the role of several proteins of the UPS in Alzheimers disease (AD) and ... Picks disease and Downs syndrome. These advances in understanding of the roles of the UPS in AD and SCI raise new questions ... is a crucial protein degradation system in eukaryotes. ... is a crucial protein degradation system in eukaryotes. ...
Höftberger, R., & Lassmann, H. (2018). Chapter 19 - Inflammatory demyelinating diseases of the central nervous system. In G. G. ... Myelin is a key component of the central nervous system. The myelin sheaths insulate axons with a triple effect: allowing fast ... Nave, K. A., & Werner, H. B. (2014). Myelination of the nervous system: mechanisms and functions. Annu Rev Cell Dev Biol, 30, ... Beaulieu, C. (2002). The basis of anisotropic water diffusion in the nervous system - a technical review. NMR in Biomedicine, ...
  • Any problem with the functioning of the autonomic nervous system, which controls unconscious body functions that affect the bladder, bowels, sweating, sexual function and blood pressure. (michaeljfox.org)
  • It also receives considerable innervation from the autonomic nervous system . (newworldencyclopedia.org)
  • Thus, it generally is considered a part of the autonomic nervous system, which is one of the two main divisions of the peripheral nervous system. (newworldencyclopedia.org)
  • It commonly is considered as part of the autonomic nervous system , which is that part of the peripheral nervous system that largely acts independent of conscious control (involuntarily). (newworldencyclopedia.org)
  • The other subdivisions of the autonomic nervous system are the sympathetic nervous system and the parasympathetic nervous system. (newworldencyclopedia.org)
  • In the pathological state α-syn changes from a soluble monomer to pathological oligomers and fibrils, which participate in the occurrence and development of various central nervous system diseases, including Parkinson's disease (PD), Lewy body dementia, and cerebrovascular diseases. (conditionmed.org)
  • 7 The disease is characterised by demyelination and axonal loss leading to neurological impairment and severe disability. (businesswire.com)
  • 8,9 Relapsing forms of MS include clinically isolated syndrome, relapsing-remitting MS (which makes up 85 percent of all MS cases), and secondary progressive MS. 10 In addition to the debilitating neurological symptoms of the disease, patients often also suffer from "hidden symptoms," namely fatigue and depression, both of which are major contributors to reduced quality of life. (businesswire.com)
  • Neurological diseases are recognized as major causes of disability and mortality worldwide. (mdpi.com)
  • A growing body of evidence suggests that inflammatory processes and an imbalance in the composition and function of the gut microbiome, which play a critical role in the pathogenesis of various neurological diseases and dietary interventions, such as the Mediterranean diet the DASH diet, or the ketogenic diet can have beneficial effects on their course. (mdpi.com)
  • Myelin is also relevant from a clinical perspective, given that demyelination is often observed in several neurological diseases such as multiple sclerosis ( Höftberger & Lassmann, 2018 ). (biorxiv.org)
  • In advanced stages the disease affects the central nervous system, causing severe neurological and mental disorders and making the individual dependent on others. (who.int)
  • However, there are many treatment -related complications , including organ disorders, graft-versus-host disease (GVHD), and infectious diseases . (bvsalud.org)
  • Furthermore, there are many unclear points regarding central nervous system (CNS) complications , and the prognosis in patients with CNS complications is extremely poor. (bvsalud.org)
  • The study, which enrolled 200 U.S. patients with RMS measured multiple sclerosis (MS)-related fatigue and its impact on daily life using the Fatigue Symptoms and Impacts Questionnaire - Relapsing Multiple Sclerosis (FSIQ-RMS), a novel disease-specific scale developed using methods consistent with the U.S. Food & Drug Administration guidelines. (businesswire.com)
  • Many of the symptoms of Parkinson's disease are brought on by loss of or damage to dopamine neurons in this region, which encompasses the striatum, the subthalamic nucleus, and the substantia nigra. (michaeljfox.org)
  • The illness was first identified in 1985 when the vet, puzzled by odd symptoms he had seen in cattle, consulted scientists at the Central Veterinary Laboratory in Weybridge, Surrey. (cnn.com)
  • The WHO says human sufferers of the disease usually experience psychiatric symptoms early in the illness, which most commonly take the form of depression and anxiety or less often, a schizophrenia-like psychosis. (cnn.com)
  • Dr. Turner specializes in cognitive behavioral neurology, memory disorders, Alzheimer's disease and Neurodegenerative dementias. (healthwellfoundation.org)
  • However, there are a number of disorders that can affect the enteric nervous system and some evidence for age-associated changes in innervation contributing to increasing disorders in the elderly. (newworldencyclopedia.org)
  • The most-reported TEAEs among all treatment groups were nervous system disorders and infections and infestations. (medscape.com)
  • Multiple sclerosis (MS) is a potentially disabling disease that affects the brain and spinal cord. (medicalnewstoday.com)
  • Rabies is a deadly disease that affects the central nervous system and is most commonly transferred to humans through a bite from a rabid animal. (cdc.gov)
  • Pediatric central nervous system infections and inflammatory white matter disease. (wakehealth.edu)
  • MS is a chronic autoimmune inflammatory disease of the central nervous system. (businesswire.com)
  • Intestinal blood supply and mucosal epithelial water and electrolyte transport are also regulated by the enteric nervous system. (newworldencyclopedia.org)
  • Emerging Infectious Diseases , 29 (9), 1719-1729. (cdc.gov)
  • Emerging Infectious Diseases , 29 (9), 1730-1737. (cdc.gov)
  • Virus infections and the developing nervous system / edited by R. T. Johnson and G. Lyon. (who.int)
  • Alzheimer's disease ranks as one of the toughest nuts to crack within drug discovery and development. (healthwellfoundation.org)
  • Dr. Porsteinsson is the Director of the University of Rochester Alzheimer's Disease Care, Research and Education Program and has devoted his career to the care and study of individuals with… more . (healthwellfoundation.org)
  • According to a report from the Alzheimer's Foundation of America, as many as 5.1 million Americans may have Alzheimer's Disease (AD), a figure that is expected to triple to nearly 13.8 million by 2050. (healthwellfoundation.org)
  • Due to the dynamic progress of diseases such as Alzheimer's disease (AD), Parkinson's Disease (PD), Schizophrenia, Depression, and Multiple Sclerosis (MD), scientists are mobilized to look for new and more effective methods of interventions. (mdpi.com)
  • Herein, we will review advances in the understanding of the role of several proteins of the UPS in Alzheimer's disease (AD) and functional recovery after spinal cord injury (SCI). (frontiersin.org)
  • My fascination for being a "disease detective" stuck with me as I grew older and I focused my schooling on microbiology and Zoonotic diseases (disease that is spread from animals to humans). (cdc.gov)
  • We also propose potential clinical applications of α-syn as helpful biomarkers or therapeutic targets in different central nervous system diseases. (conditionmed.org)
  • The copper panel revealed normal copper levels, which excluded Wilson disease as a cause of central nervous system dysfunction. (medscape.com)
  • Infection can result in fatal human disease or severe neurologic outcomes if it is not treated rapidly. (cdc.gov)
  • Although raccoons are typically asymptomatic when infected with the parasite, the larval form of Baylisascaris procyonis can result in fatal human disease or severe neurologic outcomes if not treated rapidly. (cdc.gov)
  • A movement disorder sometimes confused with Parkinson's disease that manifests in low, repetitive, involuntary, writhing movements of the arms, legs, hands, and neck that are often especially severe in the fingers and hands. (michaeljfox.org)
  • PeV-A3 is most often associated with severe disease. (cdc.gov)
  • Poorly controlled maternal diabetes mellitus (Oligohydramnios may also be seen if severe vascular disease is present. (medscape.com)
  • Types histologiques des tumeurs du système nerveux central / K. J. Zülch, avec la collaboration de pathologistes de 14 pays. (who.int)
  • Un défi au monde entier : la lutte contre les maladies du système nerveux central et périphérique. (who.int)
  • Prof. Montalban established the first MS center in Spain (The Multiple Sclerosis Center of Catalonia - Cemcat), championing a holistic approach to managing the disease, and incorporating digital approaches to better track individuals' disease activity. (nationalmssociety.org)
  • However, many researchers suggest that the condition is an autoimmune disease that attacks the myelin sheath - that is, the protective layer surrounding the nerves that help electrical signals to travel from the brain to the rest of the body - in the brain and spinal cord. (medicalnewstoday.com)
  • The enteric nervous system is very complex and has many more neurons than the spinal cord . (newworldencyclopedia.org)
  • The peripheral nervous system is that part of the vertebrate nervous system outside of the brain and spinal cord. (newworldencyclopedia.org)
  • Control of brain and nerve diseases : a world-wide challenge. (who.int)
  • It is a type of brain disease called leukodystrophy. (medlineplus.gov)
  • The chemical measurements are used to measure the effects of variability in function, disease, and pharmacology on the concentrations of brain glutamate, glutamine, GABA and other compounds that are important for brain activity. (yale.edu)
  • It is possible to observe the synthesis of glutamate, glutamine, GABA, and other compounds in the intact brain, with collaborative studies to examine other systems. (yale.edu)
  • The goals of the laboratory are to acquire the necessary data and create concrete mathematical expressions of the metabolic regulation of metabolism in the brain and other systems. (yale.edu)
  • A decade later in 1996 the British Government conceded people were falling victim to a degenerative new brain disease linked to BSE. (cnn.com)
  • His work on the natural history of MS and tracing the meaning of MRI lesions in specific areas of the brain have contributed much to our understanding of MS, as well as informing the development of the McDonald Diagnostic Criteria for MS, which have made diagnosing the disease faster and more precise. (nationalmssociety.org)
  • Similarities between the enteric nervous system and the central nervous system has led to the the ENS being referred to as the "second brain. (newworldencyclopedia.org)
  • Myelin is a key component of the central nervous system. (biorxiv.org)
  • In addition, various forms of α-syn can be transmitted through different body fluids, raising the possibility that it can be used as a biomarker to help diagnose central nervous system diseases. (conditionmed.org)
  • This review explains the physiological functions of α-syn, the effects of different forms of pathological α-syn, summarizes the research progress relating to α-syn in different forms and sources as biomarkers for PD, and explores the potential role of α-syn in other central nervous system diseases and the possibility of α-syn as a biomarker for these diseases. (conditionmed.org)
  • For example, high blood pressure is a biomarker of potential cardiovascular disease. (michaeljfox.org)
  • No validated biomarker of Parkinson's disease currently exists. (michaeljfox.org)
  • Novel infectious agents and the central nervous system. (who.int)
  • With models, researchers can study the mechanisms of a disease and test therapies. (michaeljfox.org)
  • At present, disease-modifying therapies (DMTs) are the best strategy to slow the course of MS. DMTs reduce the frequency and severity of relapses - or attacks and exacerbations - and the development of new lesions, and slow down the progression of disability. (medicalnewstoday.com)
  • Disease-modifying therapies (DMTs), particularly targeted biologics, have revolutionized the treatment of MS, including RRMS. (medscape.com)
  • Alpha-synuclein (α-syn) is a protein widely expressed in the central nervous system. (conditionmed.org)
  • Aggregation of the protein alpha-synuclein is found in Lewy bodies, a pathological hallmark of Parkinson's disease. (michaeljfox.org)
  • Central nervous system tuberculosis (TB) was identified in 20 cases of unexplained encephalitis referred to the California Encephalitis Project. (cdc.gov)
  • Tuberculosis (TB) of the central nervous system (CNS) is classically described as meningitis. (cdc.gov)
  • Preclinical studies have shown that AMT-130 lowers huntingtin protein and is associated with decreased progression of Huntington's Disease signs in animal models. (clinicaltrials.gov)
  • This trial consists of a blinded 12-month (Cohort 1 & 2) and 12-month (Cohort 3A & 3B) Core Study Period to evaluate the safety and potential impact of AMT-130 on disease progression and an unblinded 4-year Long-Term Period with periodic follow-up visits to evaluate the safety of AMT-130 and disease progression in treated individuals. (clinicaltrials.gov)
  • The aim of this review was to take a closer look at the role of diet and its ingredients in modulating inflammation associated with the development and/or progression of central nervous system diseases. (mdpi.com)
  • The enteric nervous system (ENS) is that part of the peripheral nervous system of vertebrates that plays a fundamental role in control of the gastrointestinal system. (newworldencyclopedia.org)
  • The enteric nervous system is embedded in the lining of the gastrointestinal system, including innervating areas around the intestines , pancreas , and gall bladder . (newworldencyclopedia.org)
  • Neoplasia are tumors that grow and obstruct the gastrointestinal system. (dog-health-guide.org)
  • Baylisascariasis is not a nationally notifiable disease in the United States, and little is known about how commonly it occurs or the range of clinical disease in humans. (cdc.gov)
  • One of the cardinal clinical features of Parkinson's disease, the slowing down and loss of spontaneous and voluntary movement. (michaeljfox.org)
  • Ongoing surveillance will improve understanding of the incidence and clinical severity of this emerging disease. (cdc.gov)
  • The idea behind autologous hematopoietic stem cell transplantation (AHSCT) is to "reboot" the immune system in people with MS. Hematopoietic, or blood cell-producing, stems cells derived from the person's own (autologous) blood or bone marrow are collected and stored. (medicalnewstoday.com)
  • White blood cells, which form part of the immune system and are found in the lymph glands, were isolated as one of the high-risk tissues for BSE infection. (cnn.com)
  • The enteric nervous system may also be involved in a complex interplay with the immune system (Hopley and van Schalkwyk 2006). (newworldencyclopedia.org)
  • HAT is the only vector-borne parasitic disease with a geographical distribution limited to the African continent. (who.int)
  • A class of drugs used to treat mild to moderate dementia in Parkinson's disease. (michaeljfox.org)
  • A genetic mutation in this protein is the basis for a rare inherited form of Parkinson's disease. (michaeljfox.org)
  • A class of drugs often effective in reducing the tremor of Parkinson's disease. (michaeljfox.org)
  • Some studies have linked oxidative damage to Parkinson's disease. (michaeljfox.org)
  • A medicine used to treat Parkinson's disease. (michaeljfox.org)
  • It works harmoniously with the various organs of the digestive system, and in cooperation with the rest of the nervous system, to allow proper digestive function. (newworldencyclopedia.org)
  • Conditions that block the digestive system and causes a dog stomach blockage includes ulcers and gastritis. (dog-health-guide.org)
  • Progressive multifocal leukoencephalopathy (PML), a rare and potentially fatal demyelinating disease of the central nervous system, is associated with some DMTs - notably ref-NTZ. (medscape.com)
  • The complex behaviors of the bowel are regulated by the enteric nervous system, including propulsive peristalitic movement and various movements that result in mixing. (newworldencyclopedia.org)
  • Central nervous system diseases are characterized by slow onset, occultation, and progressive aggravation, which makes the diagnosis of these diseases very difficult. (conditionmed.org)
  • Moreover, many diseases can only be identified at autopsy, so more effective methods are needed for early and differential diagnosis. (conditionmed.org)
  • Confirmed diagnosis of Fabry disease. (clinicaltrials.gov)
  • Concurrent culture positive pulmonary disease was found in 4 (50%) of 8 patients tested. (cdc.gov)
  • 44. Pulmonary disease is diagnosed. (medscape.com)
  • 2. The disease progresses through two stages following an asymptomatic period of several weeks or months. (who.int)
  • During May 2013-December 2015, seven cases of baylisascariasis not already described in the literature were identified among patients in the United States through testing at CDC, including six cases of central nervous system disease and one of ocular disease. (cdc.gov)
  • This study will evaluate the safety and efficacy of Replagal in patients with Fabry disease who are either naive to treatment, who were previously treated with agalsidase beta, or who had previously received Replagal. (clinicaltrials.gov)
  • Patients diagnosed with Fabry disease who have not previously received treatment, who have received agalsidase beta, or who had previously received Replagal will be eligible to enroll in the study and will receive Replagal at a dose of 0.2 mg/kg body weight administered by an IV infusion over 40 minutes every other week. (clinicaltrials.gov)
  • An Open-label Treatment Protocol to Evaluate the Safety of Replagal Treatment in Patients With Fabry Disease. (clinicaltrials.gov)
  • Patients with HIV infection may have a form of the disease that closely resembles the juvenile type. (medscape.com)
  • UBB+1, which arises through a frame-shift mutation in the ubiquitin gene that adds 19 amino acids to the C-terminus of ubiquitin, inhibits proteasomal function and is associated with increased neurofibrillary tangles in patients with AD, Pick's disease and Down's syndrome. (frontiersin.org)
  • Still mad cow disease, and its jump from cattle to humans, mystifies scientists and inspires public fear. (cnn.com)
  • Despite previous denials that BSE could infect humans, ministers now accepted variant Creutzfeldt-Jakob disease (vCJD) was most likely caused by infected meat. (cnn.com)
  • But many questions still need answers -- how did BSE develop in cattle, how did the disease cross species to infect humans as vCJD and what factors affect whether a human will contract the disease. (cnn.com)
  • Early-onset Krabbe disease appears in the first months of life. (medlineplus.gov)
  • Late-onset Krabbe disease begins in late childhood or early adolescence. (medlineplus.gov)
  • With late onset Krabbe disease, vision problems may appear first, followed by walking difficulties and rigid muscles. (medlineplus.gov)
  • On average, infants with early-onset Krabbe disease die before age 2. (medlineplus.gov)
  • Unfortunately, due to lack of regular surveillance activities and reduced resource allocation to HAT as well as changing health priorities and nonavailability of drugs, the disease has been neglected. (who.int)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to inform clinicians and public health departments that parechovirus (PeV) is currently circulating in the United States. (cdc.gov)
  • Turkey's geographical position, its close proximity to countries in a state of war and with low vaccination coverage, and receiving extensive immigration always raises the possibility of a reintroduction of formerly eradicated vaccine-preventable diseases such as polio (7). (who.int)
  • This system is capable of autonomous functions, acting independent of conscious control, such as the coordination of reflexes. (newworldencyclopedia.org)
  • The most accepted explanation is that the disease is caused by prions -- self-replicating proteins that contaminate neighbouring protein cells. (cnn.com)
  • The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in eukaryotes. (frontiersin.org)
  • The ubiquitin-proteasome system (UPS) is a major intracellular protein degradation system ( Schwartz and Ciechanover, 2009 ). (frontiersin.org)
  • Formed in 1980, the Alzheimer's Association advances research to end Alzheimer's and dementia while enhancing care for those living with the disease. (healthwellfoundation.org)
  • There is no specific treatment for Krabbe disease. (medlineplus.gov)
  • Some people have had a bone marrow transplant in the early stages of the disease, but this treatment has risks. (medlineplus.gov)