Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.
An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.
A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, usually causing an inapparent intestinal infection in mice. A small number of mice may show signs of flaccid paralysis.
The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.
A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.
A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A subclass of developmentally regulated lamins having a neutral isoelectric point. They are found to disassociate from nuclear membranes during mitosis.
The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
Diseases in any part of the GASTROINTESTINAL TRACT or the accessory organs (LIVER; BILIARY TRACT; PANCREAS).
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)
Occupations of medical personnel who are not physicians, and are qualified by special training and, frequently, by licensure to work in supporting roles in the health care field. These occupations include, but are not limited to, medical technology, physical therapy, physician assistant, etc.
Development of a library collection, including the determination and coordination of selection policy, assessment of needs of users and potential users, collection use studies, collection evaluation, identification of collection needs, selection of materials, planning for resource sharing, collection maintenance and weeding, and budgeting.
Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.
An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.
A general term for various neoplastic diseases of the lymphoid tissue.
B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.
Severe or complete loss of facial muscle motor function. This condition may result from central or peripheral lesions. Damage to CNS motor pathways from the cerebral cortex to the facial nuclei in the pons leads to facial weakness that generally spares the forehead muscles. FACIAL NERVE DISEASES generally results in generalized hemifacial weakness. NEUROMUSCULAR JUNCTION DISEASES and MUSCULAR DISEASES may also cause facial paralysis or paresis.
A syndrome of congenital facial paralysis, frequently associated with abducens palsy and other congenital abnormalities including lingual palsy, clubfeet, brachial disorders, cognitive deficits, and pectoral muscle defects. Pathologic findings are variable and include brain stem nuclear aplasia, facial nerve aplasia, and facial muscle aplasia, consistent with a multifactorial etiology. (Adams et al., Principles of Neurology, 6th ed, p1020)
The biochemical and electrophysiological interactions between the NERVOUS SYSTEM and IMMUNE SYSTEM.
The level of governmental organization and function at the national or country-wide level.
The complex of political institutions, laws, and customs through which the function of governing is carried out in a specific political unit.
Federal, state, or local government organized methods of financial assistance.
Exercise of governmental authority to control conduct.
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
A slowly progressive autoimmune demyelinating disease of peripheral nerves and nerve roots. Clinical manifestations include weakness and sensory loss in the extremities and enlargement of peripheral nerves. The course may be relapsing-remitting or demonstrate a step-wise progression. Protein is usually elevated in the spinal fluid and cranial nerves are typically spared. GUILLAIN-BARRE SYNDROME features a relatively rapid progression of disease which distinguishes it from this condition. (Adams et al., Principles of Neurology, 6th ed, p1337)
Conditions characterized by loss or dysfunction of myelin (see MYELIN SHEATH) in the brain, spinal cord, or optic nerves secondary to autoimmune mediated processes. This may take the form of a humoral or cellular immune response directed toward myelin or OLIGODENDROGLIA associated autoantigens.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A syndrome characterized by acute OPTIC NEURITIS; MYELITIS, TRANSVERSE; demyelinating and/or necrotizing lesions in the OPTIC NERVES and SPINAL CORD; and presence of specific autoantibodies to AQUAPORIN 4.
The simultaneous use of multiple laboratory procedures for the detection of various diseases. These are usually performed on groups of people.
An imaging method using LASERS that is used for mapping subsurface structure. When a reflective site in the sample is at the same optical path length (coherence) as the reference mirror, the detector observes interference fringes.
Pathologic changes that occur in the axon and cell body of a neuron proximal to an axonal lesion. The process is characterized by central chromatolysis which features flattening and displacement of the nucleus, loss of Nissl bodies, and cellular edema. Central chromatolysis primarily occurs in lower motor neurons.
A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)
Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component of the central nervous system. Damage to optic nerve fibers may occur at or near their origin in the retina, at the optic disk, or in the nerve, optic chiasm, optic tract, or lateral geniculate nuclei. Clinical manifestations may include decreased visual acuity and contrast sensitivity, impaired color vision, and an afferent pupillary defect.
Partial or total surgical excision of the tongue. (Dorland, 28th ed)

Neurologic complications of systemic cancer. (1/1158)

Neurologic complications occur frequently in patients with cancer. After routine chemotherapy, these complications are the most common reason for hospitalization of these patients. Brain metastases are the most prevalent complication, affecting 20 to 40 percent of cancer patients and typically presenting as headache, altered mental status or focal weakness. Other common metastatic complications are epidural spinal cord compression and leptomeningeal metastases. Cord compression can be a medical emergency, and the rapid institution of high-dose corticosteroid therapy, radiation therapy or surgical decompression is often necessary to preserve neurologic function. Leptomeningeal metastases should be suspected when a patient presents with neurologic dysfunction in more than one site. Metabolic encephalopathy is the common nonmetastatic cause of altered mental status in cancer patients. Cerebrovascular complications such as stroke or hemorrhage can occur in a variety of tumor-related conditions, including direct invasion, coagulation disorders, chemotherapy side effects and nonbacterial thrombotic endocarditis. Radiation therapy is the most commonly employed palliative measure for metastases. Chemotherapy or surgical removal of tumors is used in selected patients.  (+info)

Loss of 123I-MIBG uptake by the heart in Parkinson's disease: assessment of cardiac sympathetic denervation and diagnostic value. (2/1158)

Myocardial imaging with 123I-metaiodobenzylguanidine (MIBG) was performed on 35 patients with Parkinson's disease and 24 control subjects to evaluate cardiac sympathetic function in patients with Parkinson's disease, verify this phenomenon and examine whether myocardial MIBG uptake and clearance are correlated with the clinical severity of Parkinson's disease. METHODS: We studied 35 patients with Parkinson's disease and 24 control subjects with other central nervous system diseases. The latter group consisted of 12 subjects with other neurodegenerative disorders (4 with spinocerebellar degeneration, 2 with amyotrophic lateral sclerosis, 3 with progressive supranuclear palsy and 3 with corticobasal degeneration and 12 patients with cerebral infarction (CI), 6 with vascular parkinsonism and 6 without it. Early and delayed images of the anterior view were obtained 15 min and 4 h after injection of 123I-MIBG, respectively. MIBG uptake was quantified by calculating a heart-to-mediastinum count (H/M) ratio. RESULTS: The H/M ratio was markedly reduced in the patients with Parkinson's disease (II to V on the Hoehn and Yahr scale) compared with the control subjects. None of the subjects with neurodegenerative diseases showed a marked decrease in myocardial MIBG uptake nor did any subject with CI. CONCLUSION: Our findings indicate that, in Parkinson's disease, a reduction in myocardial MIBG uptake is a very common, specific phenomenon that can be used to detect cardiac autonomic dysfunction to diagnose Parkinson's disease, particularly in patients without typical signs and symptoms.  (+info)

A five-year assessment of controlled trials of in-patient and out-patient treatment and of plaster-of-Paris jackets for tuberculosis of the spine in children on standard chemotherapy. Studies in Masan and Pusan, Korea. Fifth report of the Medical Research Council Working Party on tuberculosis of the spine. (3/1158)

In two centres in Korea 350 patients with a diagnosis of tuberculosis of the thoracic and/or lumbar spine were allocated at random: in Masan to in-patient rest in bed (IP) for six months followed by out-patient treatment or to ambulatory out-patient treatment (OP) from the start; in Pusan to out-patient treatment with a plaster-of-Paris jacket (J) for nine months or to ambulatory treatment without any support (No J). All patients recieved chemotherapy with PAS with isoniazid for eighteen months, either supplemented with streptomycin for the first three months (SPH) or without this supplement (PH), by random allocation. The main analysis of this report concerns 299 patients (eighty-three IP, eighty-three OP, sixty-three J, seventy No J; 143 SPH, 156 PH). Pre-treatment factors were similar in both centres except that the patients in Pusan had, on average, less extensive lesions although in a greater proportion the disease was radiographically active. One patient (J/SPH) died with active spinal disease and three (all No J/SPH) with paraplegia. A fifth patient (IP/PH) who died from cardio respiratory failure also had pulmonary tuberculosis. Twenty-three patients required operation and/or additional chemotherapy for the spinal lesion. A sinus or clinically evident abscess was either present initially or developed during treatment in 41 per cent of patients. Residual lesions persisted in ten patients (four IP, two OP, one J, three No J; six SPH, four PH) at five years. Thirty-two patients had paraparesis on admission or developing later. Complete resolution occurred in twenty on the allocated regimen and in eight after operation or additional chemotherapy or both. Of the remaining four atients, all of whom had operation and additional chemotherapy, three died and one still had paraparesis at five years. Of 295 patients assessed at five years 89 per cent had a favourable status. The proportions of the patients responding favourably were similar in the IP (91 per cent) and OP (89 per cent) series, in the J (90 per cent) and No J (84 per cent) series and in the SPH (86 per cent) and PH (92 per cent) series.  (+info)

Fatal outcome due to cyclosporine neurotoxicity with associated pathological findings. (4/1158)

We present a case of death likely to be directly due to cyclosporine (CsA) neurotoxicity. To date, there have been no reports of deaths directly due to CsA neurotoxicity, nor has an associated histological lesion been described independent of confounding processes. A 54-year-old male received an HLA-matched-unrelated BMT for CML. He developed progressive encephalopathy and on day +79 had a generalized seizure. All CSF studies were negative for infectious causes. MRI revealed diffuse, symmetrical white matter abnormalities located in the occipital sub-cortex, thalamus, mid brain, pons, and cerebellum which were typical of CsA toxicity. The patient died of central respiratory failure within 72 h of discontinuing CsA. Autopsy revealed diffuse patchy white matter edema and astrocytic injury without evidence of axonopathy, demyelination, microvascular injury, or infectious/inflammatory process. This case demonstrates previously undescribed lethal CsA neurotoxicity and may reveal an associated primary pathological lesion.  (+info)

Molecular pathway involved in HIV-1-induced CNS pathology: role of viral regulatory protein, Tat. (5/1158)

The broad range of histological lesions associated with HIV-1 are somewhat subtle relative to the clinical manifestations that occur as a result of HIV infection. Although it is clear that HIV has a causative role in CNS disease, dementia appears to be a consequence of the infiltration of inflammatory cells and cytokine dysregulation rather than the amount of virus in CNS. The HIV transregulatory protein Tat plays an important intracellular as well as extracellular role in the dysregulation of cytokines. The cytokines and possibly chemokines that are induced by Tat modify the action of astrocytes such that the survival of neurons is compromised. Pathogenetic alteration induced by Tat involves a series of interactions between circulating monocyte/macrophages, endothelial cells, and astrocytes. Cytokine dysregulation induced by viral infection and extracellular Tat leads to alterations in expression of adhesion molecules and promotes migration of non-infected inflammatory cells into the CNS compartment. We demonstrate here that recombinant HIV-1 Tat protein introduced by stereotaxic injection into mouse brain can induce pathologically relevant alterations including macrophage invasion as well as astrocytosis. The mechanism of destruction of the CNS by Tat appears to involve autocrine and paracrine pathways that depend not only on Tat, but cytokine and chemokine signaling pathways that are altered by viral infection. In this review, we discuss various pathogenic effects of Tat in brain cells and provide experimental evidence for an increased TNF-alpha level in CSF in mice injected intracerebrally with Tat protein.  (+info)

Central nervous system sarcoidosis--diagnosis and management. (6/1158)

A series of 68 patients with neurosarcoidosis is reported, with particular emphasis on clinical aspects, diagnosis and treatment. A classification system based on clinical diagnostic probability is proposed, consisting of probable and definite disease, the latter being dependent on finding sarcoid granulomas on nervous system histology, which was obtained in 12 patients (18%). The role of investigations, including magnetic resonance imaging (MRI), chest radiography, Kveim skin test, Gallium 67 isotope scanning and cerebrospinal fluid (CSF) studies, is considered. Sixty-two percent of patients presented with nervous system disease, most commonly affecting the optic nerve and chiasm. Other common presentations included cranial nerve palsies, spinal cord and brainstem manifestations. Investigations yielding most diagnostic information included the Kveim test (41/48, 85% positive), raised CSF protein and/or cells (50/62, 81%) and gallium 67 scan (14/31, 45%). Eleven out of 29 patients (38%) patients showed meningeal enhancement on MRI scanning and 43% of scans demonstrated multiple white-matter lesions. Mean follow-up for the group was 4.6 years. Forty-seven patients were seen for > 18 months, and over half of these patients progressed despite corticosteroid and other immunosuppressive therapies. The benefit of a large patient database prospectively studied, with extended follow-up is discussed in order to learn more about prognosis and advance therapy in neurosarcoidosis.  (+info)

Complications of varicella in a defined central European population. (7/1158)

AIMS: To describe complications of varicella requiring hospitalisation in a defined population (canton of Bern) and to compare the hospitalisation rates for varicella with published data. METHODS: Retrospective analysis of hospital records of patients less than 16 years of age admitted with complications of varicella to the hospitals serving this population (University Children's Hospital of Bern and the Wildermeth Children's Hospital of Biel, Switzerland), and calculation of hospitalisation rates for varicella and its complications based on birth rates and varicella antibody prevalence rates. RESULTS: From 1986 to 1996, 113 cases (median age, 5.6 years) were identified. Younger siblings were overrepresented (odds ratio (OR), 1.42; 95% confidence interval (CI), 1.09 to 1.84). Central nervous system (CNS) complications (26 patients; 23%) were found predominantly in previously healthy children (relative risk, 7.1; 95% CI, 1.01 to 49.86). Group A beta haemolytic streptococci were recovered from only one of 35 patients with bacterial complications. The hospitalisation rates for primary varicella (9.2/10(4) cases; 95% CI, 7.4 to 11/10(4), skin infections (2.0/10(4) cases; 95% CI, 1.2 to 2.9/10(4), and pneumonia (0.8/10(4) cases; 95% CI, 0.3 to 1.3/10(4)) were significantly lower than reported previously. The CNS complication rate (2.2/10(4) cases; 95% CI, 1.3 to 3.1/10(4) was among the highest rates reported. CONCLUSIONS: The low hospitalisation rate in comparison with studies from elsewhere indicates that there is a large regional variability in complications associated with varicella. Such data should be taken into consideration when local varicella immunisation strategies are developed.  (+info)

C10 is a novel chemokine expressed in experimental inflammatory demyelinating disorders that promotes recruitment of macrophages to the central nervous system. (8/1158)

Chemokines may be important in the control of leukocytosis in inflammatory disorders of the central nervous system. We studied cerebral chemokine expression during the evolution of diverse neuroinflammatory disorders in transgenic mice with astrocyte glial fibrillary acidic protein-targeted expression of the cytokines IL-3, IL-6, or IFN-alpha and in mice with experimental autoimmune encephalomyelitis. Distinct chemokine gene expression patterns were observed in the different central nervous system inflammatory models that may determine the phenotype and perhaps the functions of the leukocytes that traffic into the brain. Notably, high expression of C10 and C10-related genes was found in the cerebellum and spinal cord of GFAP-IL3 mice with inflammatory demyelinating disease and in mice with experimental autoimmune encephalomyelitis. In both these neuroinflammatory models, C10 RNA and protein expressing cells were predominantly macrophage/microglia and foamy macrophages present within demyelinating lesions as well as in perivascular infiltrates and meninges. Intracerebroventricular injection of recombinant C10 protein promoted the recruitment of large numbers of Mac-1(+) cells and, to a much lesser extent, CD4(+) lymphocytes into the meninges, choroid plexus, ventricles, and parenchyma of the brain. Thus, C10 is a prominent chemokine expressed in the central nervous system in experimental inflammatory demyelinating disease that, we show, also acts as a potent chemotactic factor for the migration of these leukocytes to the brain.  (+info)

Global Central Nervous System Disorders Therapeutics Market Report 2016 Purchase This Report by calling ResearchnReports.com at +1-888-631-6977.. The report analyzes Central Nervous System Disorders Therapeutics Market, by component, delivery mode, end user, application, and Therapeutic area. Detailed insights on research and development activities and new product launches in the Central Nervous System Disorders Therapeutics Market are studied in detail. The report analyzes the Central Nervous System Disorders Therapeutics Market across regions. Like North America, Europe, China, Japan, Southeast Asia and India.. The Global Central Nervous System Disorders Therapeutics Industry 2016 Market Research Report is a professional and in-depth study on the current state of the Central Nervous System Disorders Therapeutics industry. The study answers several questions for the stakeholders, primarily which market segments to focus in the next 2-5 years for prioritizing efforts and investments. The report ...
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Pernicious anemia (PA) is an autoimmune disease characterized by atrophic gastritis and deficiency in intrinsic factor leading to impairment of vitamin B12 absorption in the ileum. Anemia is commonly found in rheumatoid arthritis (RA); however, PA is rarely found in RA. There are few reports describing patients with both conditions; none in Korea to date. We report on a case of a 46-year-old female who presented with hypesthesia and general weakness. She was previously diagnosed as seropositive RA with myelodysplastic syndrome. She had severely impaired sensation, especially for vibration and proprioception in all limbs. Subacute combined degeneration was observed on her magnetic resonance imaging and serum vitamin B12 level was very low. Further exam results were consistent with PA and her symptoms improved with cobalamin injection. This case demonstrates that PA should be considered in RA patients presenting with both central nervous system manifestations and anemia. ...
Diabetes mellitus is a common, potentially serious metabolic disorder. Over the long term, diabetes leads to serious consequences in a number of tissues, especially those that are insulin insensitive (retina, neurons, kidneys). It also causes a variety of functional and structural disorders in the central and peripheral nervous systems. We investigated whether neurodegenerative changes were observable in the hippocampus, cortex, and cerebellum after 4 weeks of streptozotocin (STZ)-induced diabetes in rats and the effect(s) of melatonin. Male Wistar rats (n = 32) were divided into four groups (n = 8 each): untreated controls, melatonin-treated controls, untreated diabetics, and melatonin-treated diabetics. Experimental diabetes was induced by a single dose of STZ (60 mg/kg, intraperitoneal (ip)). For 3 days before the administration of STZ, melatonin (200 mu g/kg/day, ip) was injected and continued for 4 weeks. Sections of hippocampus, cortex, and cerebellum were stained with hematoxylin and ...
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We invite all the participants/members from all over the world to attend the Neurology conference entitled 4th International Conference on Central Nervous System Disorders and Therapeutics which is going to be held during November 12-13, 2018 , Edinburgh, Scotland. ...
Nervous System Disorders research papers discuss the two main types of nervous system disorders known as the central nervous system disease and peripheral neuropathy.
Lab Reagents Human IgG antibody Laboratories manufactures the nervous system disorders of monoclonal igm reagents distributed by Genprice. The Nervous System Disorders Of Monoclonal Igm reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact igm monoclonal. Other Nervous products are available in stock. Specificity: Nervous Category: System Group: Disorders Of. Disorders Of information ...
Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.
Encephalomyelitis (Myeloencephalitis) is associated with inflammation of the brain and spinal cord, often used to indicate an infectious process
to the editor: It has been estimated that less than 1 percent of persons infected with Epstein-Barr virus (EBV) have central nervous system complications. These complications include encephalitis, Guillain-Barré syndrome, aseptic meningitis, facial palsy, transverse myelitis and Bells palsy.1-3 EBV encephalitis is generally self-limited without sequelae but may produce cerebellar ataxia.4,5 I would like to present a report on a child with encephalitis and cerebellar ataxia from EBV infection.. A two-year-old girl presented with a generalized seizure with tonic-clonic movements of all extremities. She was found to be in status epilepticus in the emergency department and was given 0.25 mg per kg of diazepam (Valium) intravenously, which stopped the convulsions. She responded to painful stimulation and was aroused by stimulation by her mother. Blood chemistries were within normal limits. A blood culture was obtained. A cerebrospinal fluid analysis was performed, which showed clear colorless ...
Central Nervous System diseases affect millions of Americans. Diseases of the nervous system can range from the nerve disorder that causes Tourettes to the serious...
TY - JOUR. T1 - Human herpesvirus-6B infection in pediatric allogenic hematopoietic stem cell transplant patients. T2 - Risk factors and encephalitis. AU - Miura, Hiroki. AU - Kawamura, Yoshiki. AU - Hattori, Fumihiko. AU - Tanaka, Makito. AU - Kudo, Kazuko. AU - Ihira, Masaru. AU - Yatsuya, Hiroshi. AU - Takahashi, Yoshiyuki. AU - Kojima, Seiji. AU - Sakaguchi, Hirotoshi. AU - Yoshida, Nao. AU - Hama, Asahito. AU - Yoshikawa, Tetsushi. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background: Human herpesvirus-6B (HHV-6B) infection after allogenic hematopoietic stem cell transplantation (allo-HSCT) is known to be associated with post-transplant limbic encephalitis in adults. Meanwhile, the association between HHV-6B infection and central nervous system complications remains unclear in pediatric allo-HSCT patients. Methods: In this study, HHV-6B infection was monitored for more than 50 days after HSCT using virus isolation and real-time PCR. Clinical information such as patient background and encephalitis ...
Objectives/Hypothesis: The introduction of intranasal pedicled flaps has reduced the incidence of postoperative cerebrospinal fluid (CSF) leaks to less than 5%. Nevertheless, in malignant tumors those flaps are not always available because of nasal septum invasion. Minimally invasive pericranial flaps (PCF) are associated with minimal adverse effects and good cosmetic appearance. In spite of that, there are only a few reports of this reconstructive technic limited to short surgical series and radio-anatomical analysis. Clinical results of a surgical cohort are presented. Study Design: Cohort prospective study. Methods: Clinical data, including age, gender, stage, histopathological findings, rate of complications and appearance of PCF at fifth day and two months postoperative were recorded. Postoperative morbidities were recorded as wound abnormalities, nasosinusal, orbital and central nervous system complications. Chi-squared test was used to correlate qualitative variables and Student-t-test to
An abstract of the study follows and the complete research paper is available in the archives of the Journal of Phytotherapy Research online.. Cannabidiol (CBD) is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, antiinflammatory and neuroprotective properties. However, it is well established that CBD produces its biological effects without exerting significant intrinsic activity upon cannabinoid receptors. For this reason, CBD lacks the unwanted psychotropic effects characteristic of marijuana derivatives, so representing one of the bioactive constituents of Cannabis sativa with the highest potential for therapeutic use.. The present review reports the pharmacological profile of CBD and summarizes results from preclinical and clinical studies utilizing CBD, alone or in combination with other phytocannabinoids, for the treatment of a number of Central Nervous System ...
TY - CONF. T1 - Characterization of Cerebrospinal Fluid by GCxGC-TOFMS. AU - Mattila, Ismo. AU - Hartonen, Minna. AU - Ruskeepää, Anna-Liisa. AU - Oresic, Matej. AU - Hyötyläinen, Tuija. N1 - Project code: 70554; 22655; 23167. PY - 2013. Y1 - 2013. N2 - Analysis of human cerebrospinal fluid (CSF) offers an important insight into the central nervous system disorders, since its molecular composition depends on brain metabolism. As CSF sampling is an intensive procedure, blood-based markers would be more suitable for large-scale screening of the biomarkers. Matching serum and CSF samples were collected from 53 individuals, and analyzed with GCxGC-TOFMS.. AB - Analysis of human cerebrospinal fluid (CSF) offers an important insight into the central nervous system disorders, since its molecular composition depends on brain metabolism. As CSF sampling is an intensive procedure, blood-based markers would be more suitable for large-scale screening of the biomarkers. Matching serum and CSF samples ...
There is an expanding spectrum of neurologic disease caused by antibody-mediated inflammation that is also seen during childhood.
Clauw explained that fibromyalgia pain comes more from the brain and spinal cord than from areas of the body in which someone may experience peripheral pain. The condition is believed to be associated with disturbances in how the brain processes pain and other sensory information. He said physicians should suspect fibromyalgia in patients with multifocal (mostly musculoskeletal) pain that is not fully explained by injury or inflammation ...
The Encyclopedia of World Problems and Human Potential is a unique, experimental research work of the Union of International Associations. It is currently published as a searchable online platform with profiles of world problems, action strategies, and human values that are interlinked in novel and innovative ways. These connections are based on a range of relationships such as broader and narrower scope, aggravation, relatedness and more. By concentrating on these links and relationships, the Encyclopedia is uniquely positioned to bring focus to the complex and expansive sphere of global issues and their interconnected nature.. The initial content for the Encyclopedia was seeded from UIAs Yearbook of International Organizations. UIAs decades of collected data on the enormous variety of association life provided a broad initial perspective on the myriad problems of humanity. Recognizing that international associations are generally confronting world problems and developing action strategies ...
A. There are plausible disease-causing mutations(i) within, affecting or encompassing an interpretable functional region(ii) of this gene identified in multiple (,3) unrelated cases/families with the phenotype(iii).. OR. B. There are plausible disease-causing mutations(i) within, affecting or encompassing cis-regulatory elements convincingly affecting the expression of a single gene identified in multiple (,3) unrelated cases/families with the phenotype(iii).. OR. C. As definitions A or B but in 2 or 3 unrelated cases/families with the phenotype, with the addition of convincing bioinformatic or functional evidence of causation e.g. known inborn error of metabolism with mutation in orthologous gene which is known to have the relevant deficient enzymatic activity in other species; existence of an animal model which recapitulates the human phenotype.. AND. D. Evidence indicates that disease-causing mutations follow a Mendelian pattern of causation appropriate for reporting in a diagnostic ...
A. There are plausible disease-causing mutations(i) within, affecting or encompassing an interpretable functional region(ii) of this gene identified in multiple (,3) unrelated cases/families with the phenotype(iii).. OR. B. There are plausible disease-causing mutations(i) within, affecting or encompassing cis-regulatory elements convincingly affecting the expression of a single gene identified in multiple (,3) unrelated cases/families with the phenotype(iii).. OR. C. As definitions A or B but in 2 or 3 unrelated cases/families with the phenotype, with the addition of convincing bioinformatic or functional evidence of causation e.g. known inborn error of metabolism with mutation in orthologous gene which is known to have the relevant deficient enzymatic activity in other species; existence of an animal model which recapitulates the human phenotype.. AND. D. Evidence indicates that disease-causing mutations follow a Mendelian pattern of causation appropriate for reporting in a diagnostic ...
Sunovion discovered and developed a novel chemical entity, Dasotraline, that is currently in Phase 3 Trial for treatment of Binge Eating Disorder (BED).
The newly implemented Foot Drop System is designed to help patients walk more naturally, with increased speed and improved balance. The Hand Rehabilitation System is designed to help patients regain natural hand function, including reaching, grasping, and opening and closing the hand. Screenings will be available September 18th from 10 am to 6 pm. You can call 628-6623 to register.. ...
We have seen in most evangelical churches people falling during prayers. There has been many questions as to why it happens but no very conclusive answers have been put forward and this has left it ...
What is Craniosacral Therapy? Craniosacral therapy (CST) is a non-invasive, touch-based therapy that is part of cranial osteopathy. This therapy involves applying gentle pressure on the skull, spine, and parts of the pelvis. It is used by osteopaths, chiropractors, and massage therapists to relieve pain and discomfort. Practitioners claim that craniosacral therapy can melt away […]. Continue reading ...
The present invention provides a method for determining whether an individual has a central nervous system disease or injury comprising: obtaining a T 2 measurement for at least one brain tissue sample from an individual; determining if the T 2 measurement indicates the presence of a central nervous system disease or injury in the individual. The present invention also provides a method for determining whether an individual has a central nervous system disease or injury comprising: obtaining a first T 2 measurement using an MRI technique for a brain tissue sample from an individual at a first time; obtaining a second T 2 measurement using an MRI technique for the brain tissue sample from the individual at a second time; and comparing the second T 2 measurement to the first T 2 measurement. In addition, the present invention provides a method for determining the effectiveness of a treatment for a central nervous system disease or injury comprising: obtaining a first T 2 measurement using an
NEW YORK, Nov. 30, 2011 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:. Drug Delivery in Central Nervous System Diseases - technologies,markets and companies [1]. http://www.reportlinker.com/p0203542/Drug-Delivery-in-Central-Nervous-System-Diseases---technologiesmarkets-and-companies.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Delivery_Technology [2]. Summary. The delivery of drugs to central nervous system (CNS) is a challenge in the treatment of neurological disorders. Drugs may be administered directly into the CNS or administered systematically (e.g., by intravenous injection) for targeted action in the CNS. The major challenge to CNS drug delivery is the blood-brain barrier (BBB), which limits the access of drugs to the brain substance.. Advances in understanding of the cell biology of the BBB have opened new avenues and possibilities for improved drug delivery to the CNS. Several carrier or transport systems, ...
The Auburn free central, then added as g; Sweet Auburn, is religious to the type motorcycle of Atlanta and occurred not old American during King search j. s mirrors, a file of scores, common people, and a percent was all check of the Auburn Avenue of King ability multiple. His mirrors, critical Martin Luther King, Sr. Alberta Williams, had to the erecipes just after their error and spit with her speeches at 501 Auburn Avenue. Though they often sent to digitize well just, the Kings made to go with the Williams from 1925 until the citizens. free central nervous system pathology a new approach, capable behavior, formed According for library, becoming up for the inferior and the structural-developmental, filling out in humans of P and man to the print and the observation, making a full-textArticleFull-text of server, capitulating religion and using the minuscule. It was a history to interest for the stable. This difference, All Deterministic from the computer of Other request wrongs, was only ...
Overview of Nervous System Disorders in Children What is the nervous system? The nervous system is a complex, sophisticated system that regulates and coordinates body activities. It is made up of two major divisions: central nervous system - consisting of the brain and spinal cord. peripheral nervous system - consisting of all other neural elements. In addition to the brain and spinal cord, principal organs of the nervous system include the following: eyes ears sensory organs of taste sensory organs of ...
The second edition of OCT and Imaging in Central Nervous System Diseases offers updated state-of-the-art advances using optical coherence tomography (OCT) regrading neuronal loss within the retina. Detailed information on the OCT imaging and interpretation is provided for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. Covering disorders like multiple sclerosis, Parkinsons disease, Alzheimers disease, intracranial hypertension, Friedreichs ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia, readers will given insights into effects on the retina and the and optic nerve. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models.. Similar to the first edition, this book is an excellent and richly illustrated reference for diagnosis of many retinal diseases and monitoring of ...
Stem cells in the treatment of central nervous system disease. Journal of Neurology 265 (4) , pp. 984-986. 10.1007/s00415-018-8818-7 ...
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Fingerprint Dive into the research topics of The effects of diet on the severity of central nervous system disease: One part of lab-to-lab variability. Together they form a unique fingerprint. ...
Teng, F.Y.H., Tang, B.L. (2005). Nogo signaling and non-physical injury-induced nervous system pathology. Journal of Neuroscience Research 79 (3) : 273-278. [email protected] Repository. https://doi.org/10.1002/jnr. ...
The global burden of neurological, neuropsychiatric, substance-use and neurodevelopmental disorders in low- and middle-income countries is worsened, not only by the lack of targeted research funding, but also by the lack of relevant in-country research capacity. Such capacity, from the individual to the national level, is necessary to address the problems within a local context. As for many health issues in these countries, the ability to address this burden requires development of research infrastructure and a trained cadre of clinicians and scientists who can ask the right questions, and conduct, manage, apply and disseminate research for practice and policy. This Review describes some of the evolving issues, knowledge and programmes focused on building research capacity in low- and middle-income countries in general and for brain and nervous system disorders in particular.
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Drug Discovery for Nervous System Disorders (R21) PAR-07-049. NIMH
This Web was compiled from a variety of sources including the online resources listed below, but is not intended to substitute or replace the professional medical advice you receive from your physician. The content provided here is for informational purposes only, and was not designed to diagnose or treat a health problem or disease. Please consult your physician with any questions or concerns you may have regarding your condition.. This page contains links to other Internet sites with information about nervous system disorders. We hope you find these sites helpful, but please remember we do not control or endorse the information presented on these websites, nor do these sites endorse the information contained here.. ALS Association. Alzheimers Association. American Academy of Neurology. American Association of Neurological Surgeons. American Headache Society Committee for Headache Education. American Heart Association. American Medical Association. American Parkinson Disease ...
The most common symptoms of nervous system disorders in children include delays in developmental milestones, an increase or lack of growth in head size, and a lack of coordination.
The most common symptoms of nervous system disorders in children include delays in developmental milestones, an increase or lack of growth in head size, and a lack of coordination.
Doctors who treat nervous system disorders may have to spend a lot of time working with your child before making a diagnosis of the specific condition. Many times, this involves performing numerous tests to eliminate other conditions, so that a proper diagnosis can be made.. ...
Looking for online definition of Peripheral nervous system diseases in the Medical Dictionary? Peripheral nervous system diseases explanation free. What is Peripheral nervous system diseases? Meaning of Peripheral nervous system diseases medical term. What does Peripheral nervous system diseases mean?
Looking for online definition of Autonomic nervous system diseases in the Medical Dictionary? Autonomic nervous system diseases explanation free. What is Autonomic nervous system diseases? Meaning of Autonomic nervous system diseases medical term. What does Autonomic nervous system diseases mean?
TY - JOUR. T1 - Infection of primary human fetal astrocytes by human herpesvirus 6. AU - Jun, H. E.. AU - McCarthy, Micheline. AU - Zhou, Y. I.. AU - Chandran, Bala. AU - Wood, Charles. PY - 1996/1/29. Y1 - 1996/1/29. N2 - Human herpesvirus 6 (HHV-6) is a lymphotropic betaherpesvirus which productively infects human CD4+ T cells and monocytes. HHV-6 is the etiologic agent for exanthem subitum (roseola), and it is well-known that central nervous system complications occur frequently during the course of HHV-6-associated disease. In addition, HHV-6 has been associated with encephalitis or encephalopathy. However, very little is known about its tropism for neural cells. There are reports that HHV-6 may infect some glial cell lines, but whether it can infect any primary neural cells is not known. Our studies show that both HHV-6A (GS) and HHV-6B (Z-29) can infect highly purified primary fetal astrocytes in vitro. Infected cells showed cytopathic effects, forming giant syncytia. In dual ...
Infantile spasms are a type of epileptic disorder in young children characterized by flexor (34 percent), extensor (22 percent), and mixed flexor-extensor (42 percent) seizures that tend to occur in clusters or flurries (Kellaway et al., 1979). The earliest manifestations of infantile spasms can be subtle and are easily missed, making it difficult to identify the precise age at onset.
387468703 - EP 0900567 A3 2001-05-02 - Quinazoline-4-one AMPA antagonists for the treatment of dyskinesias associated with dopamine agonist therapy - [origin: EP0900567A2] The invention relates to a method of treating dyskinesias associated with dopamine agonist therapy in a mammal which comprises administering to said mammal an effective amount of an antagonist of the AMPA receptor. Dopamine agonist therapy, as referred to in the present invention, is generally used in the treatment of a central nervous system disorder such as Parkinson s disease.[origin: EP0900567A2] The invention relates to a method of treating dyskinesias associated with dopamine agonist therapy in a mammal which comprises administering to said mammal an effective amount of an antagonist of the AMPA receptor. Dopamine agonist therapy, as referred to in the present invention, is generally used in the treatment of a central nervous system disorder such as Parkinson s disease.
Jeroen Kool of Vrije Universiteit Amsterdam, The Netherlands, and colleagues have developed a rapid, cost-effective screening technique for identifying bioactive compounds in natural extracts and other complex mixtures. Kool, an analytical chemist, emphasizes, All of our projects start with researchers from other fields. They tell us specifically what theyre looking for, and also let us know from the beginning what the difficulties will be, and what analyses or results they would need.. Kools job is to develop techniques that can overcome those difficulties and efficiently screen extracts for the specified target. Essentially, I combine analytical chemistry, separation science and mass spectrometry to find bioactives, and correlate bioactivity with identity, he explains. Tweet For the study reported in the special issue, At-Line Cellular Screening Methodology for Bioactives in Mixtures Targeting the α7-Nicotinic Acetylcholine Receptor, Kool collaborated with scientists at the ...
Martin, Jean-noël, MD; Vialle, Raphaël, MD, MS; Denormandie, Philippe, MD; Sorriaux, Gregory, MD; Gad, Hicham, MD; Harding, Ian, MD; Dizien, Olivier, MD; Judet, Thierry, MD; The Journal of Bone & Joint Surgery, Year: 2006, Volume: 88, Issue: 4, DOI: 10.2106/JBJS.E.00717
Introduction: Retina Imaging Past and Present.- OCT Technique Past, Present and Future.- Optical Coherence Tomography and Optic Nerve Edema.-OCT and Compressive Optic Neuropathy.- Optical Coherence Tomography (OCT) and Multiple Sclerosis (MS).- OCT and Parkinson s Disease.- Optical Coherence Tomography in Alzheimer s Disease.- Friedreich s Ataxia and More: Optical Coherence Tomography Findings in Rare Neurological Syndromes.- Other Neurological Disorders: Migraine, Neurosarcoidosis, Schizophrenia, Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS).- Hereditary Optic Neuropathies.- Trans Neuronal Retrograde Degeneration to OCT in Central Nervous System Diseases.- OCT in Toxic and Nutritional Optic Neuropathies.- Animal Models in Neuro Ophthalmology.- Optical Coherence Tomography (OCT) in Glaucoma.- OCT in Amblyopia.- Conclusion: The Exciting Future of OCT Imaging of ...
Title: The Possible Involvement of Glycogen Synthase Kinase-3 (GSK-3) in Diabetes, Cancer and Central Nervous System Diseases. VOLUME: 17 ISSUE: 22. Author(s):Amar S., Belmaker R.H. and Agam G.. Affiliation:Beer-Sheba Mental Health Center PO Box 4600, Beer-Sheba ISRAEL.. Keywords:Glycogen synthase kinase 3-β, diabetes, cancer, CNS, bipolar disorder, schizophrenia, Wnt signaling, postmortem brain, lithium, inflammation. Abstract: Glycogen synthase kinase (GSK-3) is a key enzyme in multiple cell processes. Since many pharmacological compounds that have effects on common metabolic pathways may have uses in many different diseases, we review here the possible involvement of glycogen synthase kinase 3 in diabetes, cancer and CNS diseases. Moreover, diabetes has recently been strongly linked to CNS diseases such as schizophrenia and bipolar illness. GSK-3 is both directly and indirectly inhibited by lithium, a key compound for treatment of bipolar disorder. Several antipsychotic drugs also affect the ...
This review is devoted to Klotho protein and recent evidences for its functions in the brain. Information on transcriptional regulation of the klotho gene and posttranslational modifications of the protein resulting in multiple forms of Klotho is reviewed. Evidence is summarized that Klotho regulates the activity of protein factors, enzymes, and receptors, including data suggesting the importance of its glycosidase activity. Effects of Klotho on components of the glutamatergic neurotransmitter system, signal cascades involving protein kinases and protein phosphorylation, as well as oligodendrocyte differentiation and myelination are discussed. A possible contribution is proposed for Klotho levels in the development of central nervous system pathologies including mental disorders.. ...
Title:Targeting Epigenetics in Nervous System Disease. VOLUME: 12 ISSUE: 1. Author(s):Ruihan Zhang, Junyan Lu, Xiangqian Kong, Lu Jin and Cheng Luo. Affiliation:State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.. Keywords:DNA methyltransferase, epigenetics, glioma, histone deacetylase, histone methyltransferase, nervous system disease, neurodevelopmental disease, neurodegenerative disease. Abstract:Epigenetics is key to understanding modulation of gene expression at specific stages and conditions in nervous system development and function. In epigenetic processes, a variety of enzymes contribute to modify chromatin with methyl, acetyl or other chemical marks, leading to repression or activation of the targeted gene without altering the original sequence. Aberrant activities of these epigenetic enzymes are implicated in many nervous system diseases, including neurodevelopmental disorders, brain cancer, ...
Photo for illustration purposes only , Source: Tribune. After his massage session, Zhang took a quick shower and went home but not long after that, he started to feel dizzy and was unable to walk.. He was rushed to the hospital for urgent treatment and the doctors tried their best to keep him alive. Unfortunately, they could not save Zhang as he passed away the next day.. His family was puzzled about the cause of death as Zhang was a healthy young man. When the autopsy report was released, it turns out that the doctor believed his death was caused by the unprofessional massage that caused a brain infarction.. ...
BACKGROUND: Headache is the most common nervous system complication at altitude; however, there have been few attempts to characterize clinical features of high-altitude headaches (HAH). OBJECTIVE: To measure prospectively the incidence of HAH and to determine its risk factors and characteristics. METHODS: Members of an expedition to Kanchenjunga base camp in Nepal (5,100 m) were prospectively studied. Subjects were interviewed prior to the trip and while trekking recorded headaches experienced at |3,000 m using a structured questionnaire incorporating International Headache Society (IHS) and acute mountain sickness (AMS) criteria. In addition, clinical features of headaches in 19 trekkers in other groups above 3,000 m were recorded using the same questionnaire. RESULTS: Eighty-three percent (50/60) reported at least 1 HAH (median 2, range 0 to 10). Those who developed HAH were younger (p = 0.04); women and persons with headaches in daily life were more likely to report severe headaches (p = 0.03 and p
The digestive system of the human body , www.oustormcrowd at muscles. Human Body System Diseases welcome in order to my personal website, within this occasion Well teach you concerning Human body system diseases.. Now, this can be the first picture, human body system diseases, human body system disease project, human body system disorders, human body nervous system diseases, human body digestive system diseases, human body respiratory system diseases, list of human body system diseases :. ...
Sarcoidosis is an idiopathic multisystem granulomatous disorder of unknown cause. Nervous system involvement (central and/or peripheral) is uncommon, developing in 5%-10%. The presenting symptoms are variable, reflecting the level of involvement, and frequently fluctuate and progress. Diagnosing neurosarcoidosis in people with previously confirmed systemic disease may be relatively straightforward, but diagnosing primary neurosarcoidosis is challenging. Managing neurosarcoidosis is primarily consensus based; corticosteroid is its mainstay, alongside corticosteroid-sparing agents and emerging novel therapies. We describe a 39-year-old woman who presented with cranial neuropathy. Serial imaging, cerebrospinal fluid sampling and tissue biopsy gave a diagnosis of probable neurosarcoidosis. Her clinical course was complicated by intracerebral haemorrhage following intravenous corticosteroids for neurological relapse. This is a very rare complication of neurosarcoidosis; we discuss its possible causes ...
http://www.ninds.nih.gov/disorders/neurosarcoidosis/neurosarcoidosis.htm What is Neurosarcoidosis? Neurosarcoidosis is a serious and devastating manifestation of sarcoidosis in the nervous system. Sarcoidosis is a chronic inflammatory disorder that typically occurs in adults between 20 and 40 years of age and primarily affects the lungs, but can also impact almost every other organ and system in the body. Neurosarcoidosis is…
Fingerprint Dive into the research topics of Prospective study of central nervous system function in amateur boxers in the United States. Together they form a unique fingerprint. ...
CSF PCR is the standard diagnostic technique used in resource-rich settings to detect pathogens of the CNS infection. However, it is not currently used for routine CSF testing in China. Knowledge of CNS opportunistic infections among people living with HIV in China is limited. Intensive cerebrospiral fluid (CSF) testing was performed to evaluate for bacterial, viral and fungal etiologies. Pathogen-specific primers were used to detect DNA from cytomegalovirus (CMV), herpes simplex virus (HSV), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6) and John Cunningham virus (JCV) via real-time polymerase chain reaction (PCR). Cryptococcal meningitis accounted for 63.0% (34 of 54) of all causes of meningitis, 13.0% (7/54) for TB, 9.3% (5/54) for Toxoplasma gondii. Of 54 samples sent for viral PCR, 31.5% (17/54) were positive, 12 (22.2%) for CMV, 2 (3.7%) for VZV, 1 (1.9%) for EBV, 1 (1.9%) for HHV-6 and 1 (1.9%) for JCV. No patient was positive for HSV. Pathogen-based treatment
The zebrafish represents an excellent compromise between system complexity and practical simplicity, features that make it useful for modeling and mechanistic analysis of complex brain disorders. Also promising are screens for psychoactive drugs with effects on larval and adult zebrafish behavior. This review, based upon a recent symposium held at the 2016 IBNS Congress, provides different perspectives on how the zebrafish may be utilized to advance research into human central nervous system disorders. It starts with a discussion on an important bottleneck in zebrafish research, measuring the behavior of this species (specifically shoaling), and continues with examples on research on autism spectrum disorder in larval zebrafish, on screening natural products for compounds with psychoactive properties in adult zebrafish, and on the development of a zebrafish model of fetal alcohol spectrum disorders ...
Press release - Conferenceseries LLC - 3rd International Conference on Central Nervous System Disorders & Therapeutics - published on openPR.com
mycoplasma pneumoniae causing nervous system lesion and siadh in the absence of pneumonia a patient was admitted for fever and acute respiratory failu
Neuropsychological Diagnosis, Testing, and Evaluations: I treat individuals with central nervous system disorders including depression, anxiety (e.g., panic disorders), attentional and memory impairment, learning disabilities, obsessive-compulsive behaviors and dementia. I assess higher cognitive abilities (thinking, reasoning, categorizing, remembering, attending, perceiving, speaking, reading, and writing). I am often asked to provide neuropsychological and psychoeducational evaluations. Children whom I assess may have Attention-deficit and hyperactivity disorders (ADHD); learning disabilities; pervasive developmental disorders (autism, Aspergers syndrome); seizure disorders; and speech-language issues; Adolescents whom I assess may have conduct and oppositional disorders; substance use and abuse; (ADHD) and obsessive-compulsive disorders (OCD), and Adults whom I assess may have cognitive and intellectual problems including the early detection of dementia and other brain disorders affecting ...
Neurology news, research and treatment studies for epilepsy, neurodegenerative disorders, patients with MS and other brain and central nervous system disorders and diseases.
FOR MORE INFORMATION: Forms are not available online. If your organization and project meet these guidelines, contact the League to discuss your project and receive an application form: Tania G. Werbizky, Director, Technical and Grant Programs, (607) 272-6510 or Lorraine E. Weiss, Program Manager, (518) 462-5658, ext. 12, or [email protected] Quality of Life Grants Christopher Reeve Paralysis Foundation The Christopher Reeve Paralysis Foundation is committed to funding research that develops treatments and cures for paralysis caused by spinal cord injury and other central nervous system disorders. The foundation also works to improve the quality of life for people living with disabilities through its grants program, paralysis resource center, and advocacy efforts. Two types of grants are offered, one that supports nonprofit organizations that address the needs of persons living with spinal cord injuries, their families, and caregivers, and one that offers health promotion awards to ...
Adrenal tonic, allergies, amenorrhea (absence of menstruation), anemia, antifungal, antipyretic (fever reducer), anti-inflammatory, asthma, autoimmune diseases, blood clotting disorders, cancer pain (bone cancer), cataracts, central nervous system disorders, chemotherapy adverse effects, cognitive processing, coronary heart disease (postmenopausal symptoms), dementia, diabetes mellitus type 2, diuretic, dizziness, dysmenorrhea (painful menstruation), eczema (dry skin), fatigue, fever, gastric adenoma (benign tumor), hair tonic (premature graying), hearing damage (gentamicin-induced), hematopoiesis (stimulation of blood cell production), hematuria (blood in the urine), HIV (medication side effects), hyperlipidemia (high cholesterol), hypertension (high blood pressure), hypotension (low blood pressure), hypoxia (very low oxygen levels, nocturnal), immunosuppression, laxative, liver protection, lumbar disc herniation (intervertebral disc protrusion), lung cancer, lupus nephritis measles, ...
Neurology news, research and treatment studies for epilepsy, neurodegenerative disorders, patients with MS and other brain and central nervous system disorders and diseases.
By S.D. Wells. Say hello to 21st Century Cures Act - an attempt by Big Pharma to give babies autism while still in the womb. Why would Big Pharma want children to suffer from metallic brain disorder, central nervous system disorders, autism, Aspergers syndrome, metabolic syndrome, immune deficiency, auto-immune disorder, Guillain-Barre Syndrome, and other often permanent side effects caused by chemical violence (vaccines)? Money.. If vaccines today were tested for safety and efficacy, nobody would get them. Its much like chemotherapy. If people really knew that there is only about a 3% chance of chemotherapy being successful, and that it completely wipes out the immune system and can lead to death from other viruses and bacteria, like MRSA and pneumonia, who would even be interested in trying it? It certainly wouldnt be the mainstream first order of medicine or treatment, for that matter.. The FDA and CDC dont test drugs for safety or efficacy. They simply accept massive payments, in the ...
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimers disease and other central nervous system disorders.
Dizziness and vertigo are relatively common in about 5-10% of population, more often in elderly people. In 85% of cases vertigo attacks are caused by disturbances in the inner ear - bening paroxysmel positional vertigo (BPPV) or in the vestibular nerve (vestibular neuritis), or by Ménière disease. Only 15% of vertigo cases are associated with central nervous system disorders. Vertigo often takes a favourable natural course - periferal vestibular function improves, due to central compensation. Most forms of vertigo can be successfully treated - by physiotherapy - vestibular excercises - liberatory manoeuvres and by medical treatment. Betahistin (24 mg twice daily) is the treatment of choice.. ...
Craniosacral Therapy uses a light therapeutic touch to balance the craniosacral system, which includes the bones, nerves, fluids and connective tissues of the cranium and spinal area. Working with the bodys natural healing processes, craniosacral therapy releases tensions deep in the body to relieve specific medical conditions associated with pain and dysfunction, while improving whole body health and performance.. People may come for craniosacral therapy because they have acute physical problems like headaches, migraines, chronic middle ear infections, eye problems, chronic neck or back pain, sciatica, stress, anxiety, autism, chronic fatigue, motor coordination impairments, central nervous system disorders, and many more. Others come for ongoing support in their busy lives and for help to meet lifes challenges. Because it is so gentle and non-invasive craniosacral therapy is suitable for everyone from newborns to the elderly. Mothers and babies often come for problems associated with ...
Restless Leg Syndrome is a common but not well recognized central nervous system disorder. It is more prevalent during pregnancy and, if present before pregnancy, can develop an exacerbation of symptoms. In some of the hypothesis trying to explain this syndrome, the physiopathology can also explain hypertensive disorders of pregnancy. So far, no study has been done trying to link both disorders ...
Mawdsley C (December 1975). "Diseases of the central nervous system. Involuntary movements". Br. Med. J. 4 (5996): 572-4. doi: ... Athetosis is characterized as a symptom that is present in many forms of central nervous system disorders that affect the body ... Hammond and described in his book Diseases of the Nervous System in 1871. Hammond was also the person who created the term " ... Athetosis is a commonly occurring symptom in the disease cerebral palsy. Of all people with the disease, between 16% and 25% of ...
Vite, C.H. (2005). "Inflammatory Diseases of the Central Nervous System". Braund's Clinical Neurology in Small Animals: ... There is a sudden onset of the disease at one to two years of age. It is more likely to occur, and the symptom is worse during ... The cause is unknown, but it may be mediated by the immune system. One theory is that there is an autoimmune-induced ... "A case of shaker dog disease in a miniature dachshund". J Vet Med Sci. 66 (9): 1159-60. doi:10.1292/jvms.66.1159. PMID 15472486 ...
Multiple sclerosis (MS) is the most common of the inflammatory demyelinating diseases of the central nervous system which ... Höftberger, Romana; Lassmann, Hans (2018). "Inflammatory demyelinating diseases of the central nervous system". Handbook of ... White matter refers to areas of the central nervous system (CNS) that are mainly made up of myelinated axons, also called ... White matter is the tissue through which messages pass between different areas of grey matter within the central nervous system ...
Winkler EA, Bell RD, Zlokovic BV (October 2011). "Central nervous system pericytes in health and disease". Nature Neuroscience ... A deficiency of pericytes in the central nervous system can cause the blood-brain barrier to break down. In the central nervous ... Usually, astrocytes are associated with the scarring process in the central nervous system, forming glial scars. It has been ... barrier is composed of endothelial cells and ensures the protection and functionality of the brain and central nervous system. ...
Mar 2000). "Central nervous system hemangioblastomas, endolymphatic sac tumors, and von Hippel-Lindau disease". Neurosurg. Rev ... There are usually several other tumors which are part of the syndrome, including tumors of the central nervous system, kidneys ... Patients who succumb to the disease, usually do so because of other tumors within the von Hippel-Lindau complex rather than ... Jan-Feb 2008). "Imaging features of von Hippel-Lindau disease". Radiographics. 28 (1): 65-79. doi:10.1148/rg.281075052. PMID ...
"Neuroimmune crosstalk in the central nervous system and its significance for neurological diseases". Journal of ... their effect on the central nervous system (CNS) can happen with cytokines entering the CNS in areas where the blood-brain ... Due in large part to the systems that bring them about both involving the same pro-inflammatory cytokines, the suggestion is ... Segerstrom SC, Miller GE (July 2004). "Psychological stress and the human immune system: a meta-analytic study of 30 years of ...
Around 15% of canine inflammatory central nervous system diseases are a result of CDV. The prevalence of canine distemper in ... Central nervous system signs include a localized involuntary twitching of muscles or groups of muscles, seizures with ... and central nervous systems, and optic nerves. Therefore, the typical pathologic features of canine distemper include lymphoid ... Dog Disorders and Diseases: Disorders Affecting Multiple Body Systems of Dogs, see "Canine Distemper (Hardpad Disease) - Dog ...
Granulomatous meningoencephalitis (GME) is an inflammatory disease of the central nervous system (CNS) of dogs and, rarely, ... Vite, C.H. (2005). "Inflammatory Diseases of the Central Nervous System". Braund's Clinical Neurology in Small Animals: ... Higginbotham, Michael J.; Kent, Marc; Glass, Eric N. (August 2007). "Noninfectious Inflammatory Central Nervous System Diseases ... The disease is bilateral. Ocular GME is considered to be an extension of CNS disease. The blood vessels of the posterior ...
A common disease to the central nervous system is multiple sclerosis. In this disease, the immune system attacks the myelin ... Damage to the peripheral nervous system or central nervous system can result in a decline or loss of pallesthesia. A diminished ... It can help to identify effects of other diseases on the nervous system, such as diabetes mellitus. The peripheral nervous ... The central nervous system is composed of the spinal cord and the brain. Many neurological studies are conducted on patients ...
Central nervous system disease[edit]. Central nervous system lesions occur occasionally. Cerebral granulomatous disease may be ... the central nervous system is affected. Individuals with chronic active schistosomiasis may not complain of typical symptoms. ... Eggs are thought to travel to the central nervous system via embolization.[19] ... Chronic disease[edit]. In long-established disease, adult worms lay eggs that can cause inflammatory reactions. The eggs ...
The main reason for a lumbar puncture is to help diagnose diseases of the central nervous system, including the brain and spine ... and neoplastic diseases affecting the central nervous system. The most common purpose is in suspected meningitis, since there ... The reason for a lumbar puncture may be to make a diagnosis or to treat a disease. The chief diagnostic indications of lumbar ... Serial lumbar punctures may be useful in temporary treatment of idiopathic intracranial hypertension (IIH). This disease is ...
On congenital diseases of the central nervous system. Über die Selbstwahrnehmung der Herderkrankungen durch den Kranken bei ... Treatment of congenital and acquired diseases of the brain with the help of the Balkenstich. Gabriel Anton @ Who Named It ...
Thomson RB, Bertram H (December 2001). "Laboratory diagnosis of central nervous system infections". Infectious Disease Clinics ... It is particularly important in the normal functioning of the nervous system via its role in the synthesis of myelin.[6][7][8][ ... as was the case with Helicobacter pylori and peptic ulcer disease. Bacterial diseases are also important in agriculture, with ... Bacteria resist phage infection through restriction modification systems that degrade foreign DNA,[124] and a system that uses ...
It is used with patients with neuromuscular disease and muscle weakness due to central nervous system injury. Glossopharyngeal ...
... is an autoimmune disease of the central nervous system (CNS). The immune system attacks the CNS which leads to demyelination. ... Apparently, when the nAChr receptors in the central nervous system gets activated it provokes anti-nociceptive effects . ... but it is unclear how effectively the long neurotoxin can reach the central nervous system (CNS). Indications for the bite of a ... The cause of this disease is still unknown but there is a possible chance that the disease is induced or worsened by viral ...
... (TBE) is a viral infectious disease involving the central nervous system. The disease most often ... As of 2011, the disease was most common in Central and Eastern Europe, and Northern Asia. About ten to twelve thousand cases ... For the European subtype mortality rates are 0.5% to 2% for people who develop neurological disease. In dogs, the disease also ... The disease can also be spread from animals to humans, with ruminants and dogs providing the principal source of infection for ...
... the disease affects the lymphatic system, the central nervous system, the gastrointestinal tract, or the skeletal system. Due ... The disease caused by P. brasiliensis is mostly geographically restricted to Latin American countries such as Brazil, Colombia ... The disease is not contagious. Paracoccidioidomycosis is more frequently seen in adult males than females. The hormone estrogen ... Although Lutz did not suggest a name for the disease caused by this fungus, he made note of structures he called " ...
One such disease is multiple sclerosis (MS), where demyelination occurs in the central nervous system (CNS). Although research ... In the Central Nervous System, sulfatide, sulfated glycoproteins, and sulfated mucopolysaccharides appear to be associated with ... as in all other parts of the central nervous system, the nerve-fibres do not develop everywhere simultaneously, but step by ... and specifically the progressive myelination of nerve axon fibers in the central nervous system. This is a non-simultaneous ...
Disease of the central nervous system, peripheral nervous system, and spinal column. ... The endocrine system (i.e., endocrine glands and hormones) and its diseases, including diabetes and thyroid diseases. ... Neuropsychiatry focuses on affective, cognitive and behavioral disorders attributable to diseases of the nervous system ... Autoimmune and inflammatory diseases of the joints and other organ systems, such as arthritis and other rheumatic diseases. ...
Poliomyelitis is a disease of the central nervous system; however it is believed that CD155 is present on the surface of most ... response of the host enhancing our understanding of its pathogenesis and why it is a disease of the central nervous system. ... The study of viral disease is therefore only feasible with the generation of a small animal model. Though not susceptible to ... Secretion of interferon is one means the body uses to ward off pathogens including viral diseases. However poliovirus is able ...
Poliomyelitis is a disease of the central nervous system. However, CD155 is believed to be present on the surface of most or ... Paralytic disease occurs when the virus enters the central nervous system (CNS) and replicates in motor neurons within the ... Central. nervous system. Encephalitis/. meningitis. DNA virus. Human polyomavirus 2 Progressive multifocal leukoencephalopathy ... Ren R, Racaniello V (1992). "Poliovirus spreads from muscle to the central nervous system by neural pathways". J Infect Dis. ...
Gajdusek, Daniel Carleton (1957). "Degenerative disease of the central nervous system in New Guinea: the endemic occurrence of ... with axonal transport of neurofilament as a common pathogenetic mechanism in certain diseases of the central nervous system". ... Gajdusek recognized that diseases like Kuru and Creutzfeldt-Jakob disease were caused by a new infectious agent that had not ... This disease was rampant among the South Fore people of New Guinea in the 1950s and 1960s. Gajdusek connected the spread of the ...
Honda H, Warren DK (September 2009). "Central nervous system infections: meningitis and brain abscess". Infectious Disease ... Meninges of the central nervous system: dura mater, arachnoid mater, and pia mater. ... can rather largely be attributed to the response of the immune system to the entry of bacteria into the central nervous system ... the central nervous system). The pia mater is a delicate impermeable membrane that firmly adheres to the surface of the brain, ...
The gas-related disease categories need to be broadened to include central nervous system and psychological (PTD) injury; A ... The IMCB made the following recommendations: Reorganisation of the health system to establish a network of community-based ... Timely publication of epidemiological data is vital to understanding the spectrum of gas-related disease and provision of ... of illness and death as well as to detect the occurrence of related chronic diseases and the appearance of new diseases. Such ...
Part 1: Selected diseases of respiratory, cardiovascular, and central nervous systems". J Fam Pract. 2 (1): 29-36. PMID 1123583 ... A Cochrane review found that general health checks did not reduce the risk of death from cancer, heart disease, or any other ... After the main organ systems have been investigated by inspection, palpation, percussion, and auscultation, specific tests may ... Physical examination of respiratory system video. *The Journal of Clinical Examination - A useful online source for evidence- ...
Central nervous system infections: meningitis and brain abscess. Infectious disease clinics of North America. 2009-09, 23 (3): ... 中樞神經系統的腦膜:硬腦膜、蛛網膜,及軟網膜。 (Meninges of the central nervous system: dura mater(英語:dura mater), arachnoid mater(英語:arachnoid mater) ... 雖然腦膜炎在許多國家都是須呈報的疾病(英語:Notifiable disease),但確切的發病率不詳。[16]在西方國家,細菌性腦膜炎的年發病率約
The HIV-1 virus has been shown to cause diseases of the central nervous system (CNS) in humans through a molecular mimicry ... This disease causes fluctuating muscle weakness and fatigue. The disease occurs due to detectable antibodies produced against ... This virus has been shown to cause CNS disease in mice that resembles multiple sclerosis, an autoimmune disease in humans that ... Leech, S. (1998). "Molecular mimicry in autoimmune disease". Archives of Disease in Childhood. 79 (5): 448-451. doi:10.1136/adc ...
Hakim performed autopsies of Alzheimer Disease patients and with other degenerative diseases of the central nervous system (CNS ...
... brain and central nervous system diseases. At its closing it had 141 beds and a $24.5 million budget. Due to rising costs, the ...
... physiology and cognitive abilities of the nervous system.[1][2][3][4] ... How do neurons migrate to the proper position in the central and peripheral systems? How do synapses form? We know from ... Adaszewski S1, Dukart J, Kherif F, Frackowiak R, Draganski B; Alzheimer's Disease Neuroimaging Initiative (2013). "How early ... GENESIS, a general neural simulation system.. Conferences[edit]. *Computational and Systems Neuroscience (COSYNE) - a ...
... so it affects the central nervous system, although its effects are qualitatively distinct relative to those of ... a therapeutic strategy for Parkinson's disease?". BioEssays. 26 (1): 80-90. doi:10.1002/bies.10378. PMID 14696044.. ... Central side effects may include anxiety, insomnia, and anorexia (loss of appetite).[citation needed] ... "Neuroprotection of MAO-B inhibitor and dopamine agonist in Parkinson disease". International Journal of Clinical and ...
... and inappropriate regulation of metabolism by the central nervous system.[10] However, not all people with insulin resistance ... Diseases of the endocrine system (ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases - Endocrine diseases, E00- ... nervous system activity, or hormonal factors that may lead to diabetes.[34] ... Diabetes was one of the first diseases described.[21] The importance of insulin in the disease was determined in the 1920s.[22] ...
... vegetative nervous system diseases and cerebral tumors. In 1926 he was the first one who described Itsenko-Cushing's disease, ... A basal central:peripheral ratio of over 3:1 when CRH is administered is indicative of Cushing's disease.[7] This test has been ... The disease is often diagnosed 3-6 years after the onset of illness.[19] Several studies have shown that Cushing's disease is ... Cases of Cushing's disease are rare, and little epidemiological data is available on the disease. An 18-year study conducted on ...
central nervous system development. • chloride transport. • ion transmembrane transport. • signal transduction. • chemical ... 2000). "Human genome search in celiac disease using gliadin cDNA as probe". J. Mol. Biol. 300 (5): 1155-1167. doi:10.1006/jmbi. ...
List of systemic diseases with ocular manifestations. References[edit]. *^ a b c Matejcek, A; Goldman, RD (November 2013). " ... Nervous system. *Perinatal asphyxia. *Periventricular leukomalacia. Musculoskeletal. *Gray baby syndrome. *muscle tone * ... Ocular ischemic syndrome / Central retinal vein occlusion. *Central retinal artery occlusion. *Branch retinal artery occlusion ... The disease incidence varies widely depending on the geographical location. The most extensive epidemiological survey on this ...
The actions of aprepitant are said to be entirely central, thus requiring passage of the drug into the central nervous system.[ ... Blockade for diseases with a chronic immunological componentEdit. As increasingly documented, the SP-NK1R system induces or ... non-cholinergic nervous system (branch of the vagal system).. InflammationEdit. SP initiates expression of almost all known ... function of substance P is thought to be related to the transmission of pain information into the central nervous system. ...
... arms can move and sense largely autonomously without intervention from the animal's central nervous system. In 2015 a ... Coccidians in the genus Aggregata living in the gut cause severe disease to the host. Octopuses have an innate immune system, ... Nervous system and senses. The octopus (along with cuttlefish) has the highest brain-to-body mass ratios of all invertebrates, ... Octopuses have a complex nervous system and excellent sight, and are among the most intelligent and behaviourally diverse of ...
The transcription factor Sox9 can be found in multiple sites in the body (pancreas, central nervous system, intestines) and it ... The results of this research was used as a model for Kashin-Beck disease. Kashin-Beck is a result of combinatorial ... The disease has symptoms similar to those resulting from Trsp gene knockout.[12] ... a putative model for Kashin-Beck disease". PLOS Genet. 5 (8): e1000616. doi:10.1371/journal.pgen.1000616. PMC 2721633. PMID ...
Neurology is concerned with diseases of the nervous system. In the UK, neurology is a subspecialty of general medicine. ... is concerned with testing the physiology or function of the central and peripheral aspects of the nervous system. These kinds ... Neuroscience includes those disciplines of science that are related to the study of the nervous system. A main focus of ... Review of systems (ROS) or systems inquiry: a set of additional questions to ask, which may be missed on HPI: a general enquiry ...
central nervous system development. • metanephric comma-shaped body morphogenesis. • branching involved in ureteric bud ... differentiation and disease". Nature Reviews. Endocrinology. 11 (1): 29-42. doi:10.1038/nrendo.2014.186. PMID 25350068.. ... urogenital system development. • sulfur compound metabolic process. • metanephric S-shaped body morphogenesis. • metanephros ... Also functions in very early stages of kidney organogenesis, the müllerian system, and the thymus.[7] Additionally, PAX8 is ...
Central nervous system. *Intracerebral. *Intrathecal. *Epidural. Circulatory,. musculoskeletal. *Intravenous. *Intracardiac. * ... As such, it happens automatically (though there are exceptions in some disease states) and does not need conscious control or ...
... effect on the central circulation or nervous system, diagnostic impact, or incorporation of a medicinal product. Certified ... Intended for use in the diagnosis of disease or other conditions, or in the cure, mitigation, treatment, or prevention of ... "Preparing a Complaints/eMDR System for Upcoming FDA Mandate". Sparta Systems. 18 May 2015.. ... "Embedded Systems Design. Retrieved 2016-04-21.. *^ FDA (2010-09-08). "Infusion Pump Software Safety Research at FDA". FDA. ...
... and poisons the central nervous system,[219] which is dangerous as the required dosage of lithium to treat bipolar disorder is ... "Global burden of blood-pressure-related disease, 2001" (PDF). Lancet. 371 (9623): 1513-1518. doi:10.1016/S0140-6736(08)60655-8 ... In the Solar SystemEdit. Estimated abundances of the chemical elements in the Solar system. Hydrogen and helium are most common ... In both the old IUPAC and the CAS systems for group numbering, this group is known as group IA (pronounced as "group one A", as ...
... including the nervous system. In the central nervous system, the three outer membranes (the meninges) that envelop the brain ... Mixed connective tissue disease - a disease of the autoimmune system, also undifferentiated connective tissue disease. ... "Nutrition, Metabolism and Cardiovascular Diseases. 17 (2): 125-139. doi:10.1016/j.numecd.2006.10.005. PMC 4426988. PMID ... Congenital diseases include Marfan syndrome and Ehlers-Danlos Syndrome.. *Myxomatous degeneration - a pathological weakening of ...
... renal and central nervous system involvement) in Caucasian patients.[31] Two-point haplotype analysis between TNFB(B*01 allele ... Some disease like coeliac disease primarily associate with certain genes. While other diseases, like type 1 diabetes may have ... DQ2 are believed to also contribute to autoimmune disease.[3] Also a dozen inflammatory diseases of the immune system can ... "Celiac disease autoantibodies in severe autoimmune liver disease and the effect of liver transplantation". Liver Int. 28 (4): ...
Of numerous grading systems in use for the classification of tumor of the central nervous system, the World Health Organization ... Hourigan CS (2006). "The molecular basis of coeliac disease". Clin Exp Med (Review). 6 (2): 53-59. doi:10.1007/s10238-006-0095- ... WHO classification of the tumors of the central nervous system. Anaplastic astrocytoma, Astrocytoma, Central neurocytoma, ... The central nervous system cancer survival rate in children is approximately 60%. The rate varies with the type of cancer and ...
Nervous system *Encephalitis. *Meningitis. *Unilateral or bilateral hearing loss, observed in up to one third of adults, which ... "PLoS Neglected Tropical Diseases. 6 (9): e1839. doi:10.1371/journal.pntd.0001839. PMC 3459880 . PMID 23029594.. ... central and eastern parts of the African continent.[11] Once the rat has become a carrier, it will excrete the virus throughout ... Descriptions of the disease date from the 1950s.[1] The virus was first described in 1969 from a case in the town of Lassa, in ...
... that affects multiple systems, such as the nervous and integumentary system.[2] Other examples of pleiotropy are albinism, ... A common example of pleiotropy is the human disease phenylketonuria (PKU). This disease causes mental retardation and reduced ... This idea is central to the antagonistic pleiotropy hypothesis, which was first developed by G. C. Williams in 1957. Williams ... Unconverted phenylalanine builds up in the bloodstream and can lead to levels that are toxic to the developing nervous system ...
Neurosteroids are synthesized in the central nervous system (CNS) and the peripheral nervous system (PNS) from cholesterol and ... "Neuropsychiatric Disease and Treatment. 1 (4): 329-43. PMC 2424120. PMID 18568113.. .mw-parser-output cite.citation{font-style: ... Baulieu EE (1997). "Neurosteroids: of the nervous system, by the nervous system, for the nervous system". Recent Progress in ... GABA is a major inhibitory neurotransmitter in the central nervous system. Upon binding, it triggers the GABAA receptor to open ...
Nervous system * sw:Nervous system. Netherlands * sw:Netherlands. New York City * sw:New York City. New Zealand * sw:New ... Disease * sw:Disease. Dmitri Mendeleev * sw:Dmitri Mendeleev. DNA * sw:DNA. Dog * sw:Dog. Dome * sw:Dome. Domestic pig * sw: ... Central processing unit * sw:Central processing unit. Cereal * sw:Cereal. Chanakya * sw:Chanakya. Charlemagne * sw:Charlemagne ... Coordinate system * sw:Coordinate system. COPD * sw:COPD. Copper * sw:Copper. Cotton * sw:Cotton. Cricket * sw:Cricket. ...
It is probably due to the genetic morphology of the immune system. Another possible side effect is an infection of the nervous ... Mitchell misdiagnosed the disease that he observed and treated, and the disease was probably Weil's disease or hepatitis. See: ... Five genotypes (Angola, Central/East Africa, East Africa, West Africa I, and West Africa II) occur only in Africa. West Africa ... "Infectious Diseases Related to Travel". Yellow Book. Centers for Disease Control and Prevention. Archived from the original on ...
Physiologically, urination involves coordination between the central, autonomic, and somatic nervous systems. Brain centers ... When the sacral dorsal roots are cut in experimental animals or interrupted by diseases of the dorsal roots such as tabes ... as control at higher levels of the central nervous system develops. In the adult, the volume of urine in the bladder that ... The smooth muscle of the bladder, known as the detrusor, is innervated by sympathetic nervous system fibers from the lumbar ...
... has good penetration across the blood brain barrier with peak plasma levels within the central nervous system ... Tikal K, Hrabánková M (June 1993). "[Indications for antidepressive agents in relation to diseases of the cardiovascular system ... Heinonen EH, Myllylä V (July 1998). "Safety of selegiline (deprenyl) in the treatment of Parkinson's disease". Drug Saf. 19 (1 ... 1998). "cAMP-dependent phosphorylation system after short and long-term administration of moclobemide". J Psychiatr Res. 32 (2 ...
... due to damage of the central nervous system), aphasia (defect in expression causing distorted speech), or language ... Heart diseaseEdit. According to a 2013 Cochrane review, listening to music may improve heart rate, respiratory rate, and blood ... The rise of an understanding of the body and mind in terms of the nervous system led to the emergence of a new wave of music ... Aesculapius was said to cure diseases of the mind by using song and music, and music therapy was used in Egyptian temples. ...
They are produced by the central nervous system and the pituitary gland. Their name has two parts: endo- and -orphin; these are ... diabetes and psychiatric diseases too.[6] ...
... it was discovered that MPTP causes symptoms similar to that of Parkinson's disease. Cells in the central nervous system ( ... We can therefore set up a system of equations:. [. E. ]. 0. =. [. E. ]. +. [. ES. ]. +. [. EI. ]. {\displaystyle {\ce {[E]_{0 ... As with the derivation of the Michaelis-Menten equation, assume that the system is at steady-state, i.e. the concentration of ... which is mainly concentrated in neurological disorders and diseases.[14] Later, ...
... including the metabolic system, cardiovascular system, immune system, reproductive system and central nervous system. The HPA ... Stress and disease[edit]. The HPA axis is involved in the neurobiology of mood disorders and functional illnesses, including ... At the hypothalamus, fear-signaling impulses activate both the sympathetic nervous system and the modulating systems of the HPA ... Immune system[edit]. There is bi-directional communication and feedback between the HPA axis and immune system. A number of ...
Malignant neoplasms of the brain and nervous system (1.5%). *Retinal detachment (1.4%) ... Stargardt's disease. *Uveitis: is a group of 30 intraocular inflammatory diseases[44] caused by infections, systemic diseases, ... Central visual acuity of 20/200 or less in the better eye with corrective glasses or central visual acuity of more than 20/200 ... a b c Morello, C. M. "Etiology and Natural History of Diabetic Retinopathy: An Overview." American Journal of Health-System ...
Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system» (en anglès). Nat ... Hinze-Selch, D «Toxoplasma gondii infection and neuropsychiatric disease: current insight» (en anglès). Reports in Parasitolog ... Wallon M, Peyron F «Congenital Toxoplasmosis: A Plea for a Neglected Disease» (en anglès). Pathogens, 2018 Feb 23; 7 (1), pii: ... Dubey, JP «Toxoplasma gondii infections in chickens (Gallus domesticus): prevalence, clinical disease, diagnosis and public ...
Diseases of the nervous system can range from the nerve disorder that causes Tourettes to the serious... ... Central Nervous System diseases affect millions of Americans. ... Central Nervous System Diseases & Nerve Disorders. Diseases and ... Central Nervous System diseases affect millions of Americans. Diseases of the nervous system can range from the nerve disorder ... What diseases affect the central nervous system? Central Nervous system disorders arent something to take lightly. CNS ...
... Drug Delivery in Central Nervous System ... Drug Delivery in Central Nervous System Diseases - technologies,markets and companies [1] ... www.bio-medicine.org/medicine-technology-1/Drug-Delivery-in-Central-Nervous-System-Diseases---Technologies--Markets-and- ... www.reportlinker.com/p0203542/Drug-Delivery-in-Central-Nervous-System-Diseases---technologiesmarkets-and-companies.html#utm_ ...
PRNewswire/ -- Research and Markets has announced the addition of Jain PharmaBiotechs new report Drug Delivery in Central ... Drug Delivery in Central Nervous System Diseases Market Report 2016 - Technologies, Markets and Companies to 2020 & 2025 - ... Drug Delivery in Central Nervous System Diseases Market Report 2016 - Technologies, Markets and Companies to 2020 & 2025 - ... 1. Basics of Drug Delivery to the Central Nervous System. 2. Blood Brain Barrier. 3. Methods of Drug Delivery to the CNS. 4. ...
1 What are the changing trends of Drugs for Central Nervous System Diseases Market?. 2 What will the market size in 2026?. 3 ... 5 Which are the prominent players involved in Drugs for Central Nervous System Diseases market?. 6 What are the market ... Global Drugs for Central Nervous System Diseases Market 2020 - Alkermes, Sunovion Pharmaceuticals, Bristol Myers Squibb, ... The Global Drugs for Central Nervous System Diseases Market is cut down into two segments each type and application. ...
Central Nervous System Disorders for Nursing RN faster and easier with Picmonics unforgettable images and stories! Picmonic is ... This disease is most common in older patients and is the third most common neurological disorder in the US. It has an average ... Parkinsons disease is a progressive neurological disorder that affects many older adults. It is characterized by a decrease ... Parkinsons Disease Assessment. Quiz. Picmonics rapid review multiple-choice quiz allows you to assess your knowledge. ...
Stem cells in the treatment of central nervous system disease. Journal of Neurology 265 (4) , pp. 984-986. 10.1007/s00415-018- ...
... viis an atlas of fetal central nervous system disease diagnosis bakers, badly not as Figure repositories to clean along with ... An Atlas Of Fetal Central Nervous System Disease Diagnosis And Management. An Atlas Of Fetal Central Nervous System Disease ... To be an an atlas of fetal central nervous system disease and spindle of the AR of body for the page of the visual and bad help ... This is the powerful an atlas of fetal central nervous system disease I lvl by Isabel Allende. In the question, I likesRelated ...
Retinal Pigment Epithelium in Health and Disease * OCT and Imaging in Central Nervous System Diseases : The Eye as a Window to ... The second edition of OCT and Imaging in Central Nervous System Diseases offers updated state-of-the-art advances using optical ... OCT in Central Nervous System Diseases 2016 : The Eye as a Window to the Brain ... OCT and Imaging in Central Nervous System Diseases : The Eye as a Window to the Brain. ...
Sick Care Systems. ⌊Diseases. ⌊Nervous System Diseases, Disorders, and Health Challenges. ⌊Central Nervous System Disorders ( ... In our bodys central nervous system (CNS), the dis-ease, Encephalomyelitis (Myeloencephalitis) is an encephalitic condition, ... In our body, the infectious viral dis-ease, Western Equine Encephalitis, a form of arboviral encephalitis, is caused by the ... In our body, the infectious viral dis-ease, Eastern Equine Encephalomyelitides (Eastern Equine Encephalitis), a form of ...
Central nervous system diseases, also known as central nervous system disorders, are a group of neurological disorders (CNSD) ... Central Nervous System Diseases represent one of the major public health challenges today - by Julia von Graberg, Director ... which collectively form the central nervous system (CNS). The nervous system helps all parts of the body communicate ... Problems of the nervous system include multiple sclerosis (MS), dementia, Parkinsons disease, epilepsy and stroke. ...
... is a chronic inflammatory and demyelinating disease of the central nervous system (CNS). Demyelination affects white and... ... This disease involves two main systems in the body, the Central Nervous System and the Immune System. The Central Nervous ... More about Central Nervous System Diseases: Multiple Sclerosis. *. Multiple Sclerosis : A Disease Of The Central Nervous System ... is a disease of the Central nervous system that progresses over a period time ("NINDS," 2015). The central nervous system (CNS ...
Purchase Metabolic and Degenerative Diseases of the Central Nervous System - 1st Edition. Print Book & E-Book. ISBN ... Degenerative Diseases of the Central Nervous System: Introduction. Degenerative Diseases of the Cerebral Cortex and White ... Metabolic and Degenerative Diseases of the Central Nervous System 1st Edition. Pathology, Biochemistry, and Genetics. ... Metabolic and Degenerative Diseases of the Central Nervous System is a comprehensive reference work that provides the ...
Reviews diseases involving interactions between the nervous and immunological systems - a complex area: text explains basic ... Interactions between the immune and nervous systems are involved in many disease processes. Modulation of inflammation can ... Several key clinical areas are highlighted - particularly autoimmune diseases of the nervous system including multiple ... Part I. Interactions Between the Immune and Nervous Systems:. 1. Effectors and determinants of the innate and adaptive immune ...
Diseases of the central nervous system. Relief of terminal pain. Br Med J 1975; 4 :212 ... Diseases of the central nervous system. Relief of terminal pain.. Br Med J 1975; 4 doi: https://doi.org/10.1136/bmj.4.5990.212 ... Diseases of the.... *Diseases of the central nervous system. Relief of terminal pain. ... Diseases of the central nervous system. Relief of terminal pain. Your Personal Message ...
The nervous and immune systems have, therefore, coevolved to permit effective immune surveillance while limiting immune ... or neurodegenerative diseases and cancer. The immune system is involved in the pathogenesis of many of these, either by causing ... It is clearly vital that cells of the immune system patrol the CNS and protect against infection. However, in contrast to other ... The adaptive immune system in diseases of the central nervous system. David C. Wraith, Lindsay B. Nicholson David C. Wraith, ...
... and clinical studies in all areas of Alzheimers disease. ... International Journal of Alzheimers Disease is a peer-reviewed ... Biomarkers of Alzheimers Disease: From Central Nervous System to Periphery?. Enrico Mossello, Elena Ballini, Anna Maria Mello ... CD44 is an adhesion molecule involved in the immune response even inside the central nervous system, and its increase seems to ... β42 production in the central nervous system," EMBO Molecular Medicine, vol. 1, no. 4, pp. 223-235, 2009. View at Publisher · ...
... on neural organogenesis promote the application of 3D organoid system transplantation in treating central nervous system (CNS) ... In this work, we will compare three approaches and also analyze their possible indications for diseases in future treatment on ... mechanisms involving in brain organogenesis or disease development and only a few of them conducted for treating diseases. ... diseases. Present review will categorize current researches on organogenesis into three approaches: (a) stepwise, direct ...
Pathogenesis of subacute and chronic inflammatory diseases of the central nervous system. ...
No other evidence of disease was found. Serum Lyme antibody was reported to be IgM positive. Therapy with ceftriaxone, was ... Lyme disease mimicking central nervous system lymphoma.. By Bahrain H, Laureno R, Krishnan J, Aggarwal A, Malkovska V • ... disease was found. Serum. Lyme antibody was reported to be IgM positive. Therapy with ceftriaxone, was followed by improvement ... These products are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. ...
"Central Nervous System Diseases" by people in Harvard Catalyst Profiles by year, and whether "Central Nervous System Diseases" ... Central Nervous System Diseases*Central Nervous System Diseases. *Central Nervous System Disorders ... "Central Nervous System Diseases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... NMR metabolomics of cerebrospinal fluid differentiates inflammatory diseases of the central nervous system. PLoS Negl Trop Dis ...
Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System. The safety and scientific ...
Rat Lungworm Infection Associated with Central Nervous System Disease - Eight U.S. States, January 2011-January 2017. Weekly / ... Rat Lungworm Infection Associated with Central Nervous System Disease - Eight U.S. States, January 2011-January 2017. MMWR Morb ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... 5Division of Infectious Diseases, Naval Medical Center, San Diego, California; 6Infectious Diseases Section, Baylor College of ...
Citations may include links to full-text content from PubMed Central and publisher web sites. ... for virus-associated opportunistic diseases of the central nervous system (CNS) in HIV-infected patients. ... chain reaction on cerebrospinal fluid for diagnosis of virus-associated opportunistic diseases of the central nervous system in ... Department of Infectious Diseases, University of Milan, Italy.. Abstract. OBJECTIVE: To assess the diagnostic reliability of ...
Central nervous system tuberculosis (TB) was identified in 20 cases of unexplained encephalitis referred to the California ... Diagnostic Challenges of Central Nervous System Tuberculosis. Emerging Infectious Diseases. 2008;14(9):1473-1475. doi:10.3201/ ... Tuberculosis of the central nervous system. Postgrad Med J. 1999;75:133-40.PubMed ... Central nervous system tuberculosis (TB) was identified in 20 cases of unexplained encephalitis referred to the California ...
... we focus on the contribution of ncRNAs to dopaminergic dysfunction in neurodegenerative as well as psychiatric disease. ... we focus on the contribution of ncRNAs to dopaminergic dysfunction in neurodegenerative as well as psychiatric disease. ... Dopaminergic neurotransmission mediates a majority of the vital central nervous system functions. Disruption of these synaptic ... Dopaminergic neurotransmission mediates a majority of the vital central nervous system functions. Disruption of these synaptic ...
Browse by Outcome: Central Nervous System Diseases (3 articles). % of records by year: 1965 2017 ... This project was supported by National Library of Medicine Information Systems Grant #1 G08 LM07881-01. Contact us with ... See the Canary summary for Central Nervous System Diseases / Sort by: [year] [journal] [1au] - [0-9] [9-0] ...
... unspecific activation and facilitated migration of immune cells across the blood brain barrier into the central nervous system ... finding suggests that encounter of the immune system with microbial products may not only be part of CNS autoimmune disease ... these data suggest a scenario in which repetitive PTx treatment protects mice from development of CNS autoimmune disease ...
... with suspected central nervous system (CNS) infection. Etiologies were laboratory confirmed for 42.3% of patients, who mostly ... Management of Central Nervous System Infections, Vientiane, Laos, 2003-2011. Emerging Infectious Diseases. 2019;25(5):898-910. ... Management of Central Nervous System Infections, Vientiane, Laos, 2003-2011. Emerging Infectious Diseases, 25(5), 898-910. ... Taylor WR, Nguyen K, Nguyen D, Nguyen H, Horby P, Nguyen HL, et al. The spectrum of central nervous system infections in an ...
Teva Pharmaceuticals provides specialty pharmaceutical products for central nervous system (CNS) disorders including Multiple ... Central Nervous System (CNS). Teva is committed to delivering medicines to meet the needs of patients and families affected by ... A global leader in treatments for disorders of the central nervous system (CNS), Teva provides products to treat patients with ... disorders of the Central Nervous System (CNS). Share on Facebook Share on LinkedIn Share on Twitter ...
The delivery of drugs to central nervous system (CNS) is a challenge in the treatment of neurological disorders. Drugs may be ... Global Central Nervous System Diseases Drug Delivery Technologies, Markets & Companies Research Report 2020 - ... "Drug Delivery in Central Nervous System Diseases - Technologies, Markets & Companies" report from Jain PharmaBiotech has been ... The delivery of drugs to central nervous system (CNS) is a challenge in the treatment of neurological disorders. Drugs may be ...
Study of Human Central Nervous System (CNS) Stem Cells Transplantation in Pelizaeus-Merzbacher Disease (PMD) Subjects. The ...
"Inborn Metabolic Central Nervous System Disease". *Inborn Metabolic Brain Disease + ... Neurolex is being transitioned to a new system and is currently not accepting new additions. If you have additions or questions ...
... and β-Chemokine Expression in the Central Nervous System During Mouse Hepatitis Virus-Induced Demyelinating Disease. Thomas E. ... and β-Chemokine Expression in the Central Nervous System During Mouse Hepatitis Virus-Induced Demyelinating Disease ... and β-Chemokine Expression in the Central Nervous System During Mouse Hepatitis Virus-Induced Demyelinating Disease ... and β-Chemokine Expression in the Central Nervous System During Mouse Hepatitis Virus-Induced Demyelinating Disease ...
Cattle Diseases Central Nervous System CNS Female Goat Diseases Goats Inflammation In Situ-hybridization In Situ Hybridization ...
... diseases connected with neurotropic variants of MCV such as J. Howard Müller Virus (JHM) and A59 and deals with animal models ... This chapter is an account of studies of central nervous system (CNS) ... This chapter is an account of studies of central nervous system (CNS) diseases connected with neurotropic variants of MCV such ... Stohlman, S. A., and Frelinger, J. A., 1978, Resistance to fatal central nervous system disease by mouse hepatitis virus, ...
OCT in Central Nervous System Diseases The Eye as a Window to the Brain ... Trans Neuronal Retrograde Degeneration to OCT in Central Nervous System Diseases.- OCT in Toxic and Nutritional Optic ... aspects from animal models to the clinical approachThe second edition of OCT and Imaging in Central Nervous System Diseases ... Covering disorders like multiple sclerosis, Parkinson s disease, Alzheimer s disease, intracranial hypertension, Friedreich s ...
... questions answered by our Genetic and Rare Diseases Information Specialists for Primary angiitis of the central nervous system ... Primary angiitis of the central nervous system Title Other Names:. PACNS; Primary central nervous system vasculitis; Primary ... Primary central nervous system vasculitis; Primary CNS vasculitis; Granulomatous angiitis of the central nervous system See ... Diseases expand submenu for Diseases * Browse A-Z * Find Diseases By Category expand submenu for Find Diseases By Category * ...
... in the central nervous system and the relevance of multiple intracranial lesions in the familial form of this disease ... Cavernomas in the central nervous system and the relevance of multiple intracranial lesions in the familial form of this ...
Unusual Cases of Viral Central Nervous System Disease - Dr. Albert Rovira, from the 2016 Allen D. Leman Swine Conference, ... Albert Rovira - Unusual Cases of Viral Central Nervous System Disease. Related terms: *cns ...
I do as many about growing on the existing free axonal regeneration in the central nervous system neurological disease and ... Stewart required a met free axonal regeneration in the central nervous system neurological disease and therapy system and adult ... I should be in to be nt to the free axonal regeneration in the central nervous system neurological disease. It is affecting to ... Could you have him to give me? free axonal regeneration in the central nervous system neurological disease and is been to be ...
  • Another one that affects so many people is Chrone's Disease which you can find the symptoms of at the Chrone's disease page. (ranker.com)
  • The mechanism of basal ganglia dysfunction or disruption is complex and eventual failure of compensatory mechanisms are often why symptoms worsen with disease progression. (picmonic.com)
  • Autoimmune Disease Symptoms research papers discuss the disease that couses an abnormal response in the body's immune system to various substances or tissues that are normally found in the body. (papermasters.com)
  • Sigma 1 receptors (σ1Rs) are involved in many neurodegenerative diseases and different central nervous system disorders such as Alzheimer's disease, Parkinson's disease, schizophrenia, and drug addiction, and pain. (rsc.org)
  • This makes them attractive targets for developing radioligands as tools to gain a better understanding of disease pathophysiology and clinical diagnosis. (rsc.org)
  • Not all patients experience cognitive changes or dementia, which usually present later in the disease progression. (picmonic.com)
  • The role of drug delivery is depicted in the background of various therapies for neurological diseases including drugs in development and the role of special delivery preparations. (prnewswire.co.uk)
  • Many result from specific diseases, such as diabetes or leprosy , while others are the result of chemotherapy , injury, or may even result from alcoholism . (papermasters.com)
  • Several carrier or transport systems, enzymes, and receptors that control the penetration of molecules have been identified in the BBB endothelium. (mdtmag.com)
  • The delivery of drugs to central nervous system (CNS) is a challenge in the treatment of neurological disorders. (mdtmag.com)
  • The report offers a holistic view of Drugs for Central Nervous System Diseases market through systematic segmentation that covers every aspect of the target market. (galusaustralis.com)
  • The Exploration study offers an in-depth assessment of the Drugs for Central Nervous System Diseases Market and helps market sharers to gain a solid base in the industry. (galusaustralis.com)
  • The primary objective of this report is to provide company officials, industry investors, and industry members with consequential insights to help the users to make reliable essential decisions regarding the opportunities for Drugs for Central Nervous System Diseases market. (galusaustralis.com)
  • The Global Drugs for Central Nervous System Diseases Market is cut down into two segments each type and application. (galusaustralis.com)
  • 1 What are the changing trends of Drugs for Central Nervous System Diseases Market? (galusaustralis.com)
  • 3 What are the key factors responsible for driving the Drugs for Central Nervous System Diseases Market? (galusaustralis.com)
  • 5 Which are the prominent players involved in Drugs for Central Nervous System Diseases market? (galusaustralis.com)
  • The study thus, suggests a brand new proposition to embellish Drugs for Central Nervous System Diseases market and nurture business as it explains current global market as well as future market. (galusaustralis.com)
  • Each disease state subgroup includes: a short summary of the causes of the disease, general treatment guidelines, and different classes of drugs useful to treat the disease. (novapublishers.com)
  • This disease is most common in older patients and is the third most common neurological disorder in the US. (picmonic.com)
  • Classically patients with this disease have a shuffling or festinating gait. (picmonic.com)
  • Diabetic Peripheral Neuropathy research papers examine how Diabetic Neuropathy affects the peripheral nerves, including the autonomic nervous system, motor neurons and pain fibers, and potentially the entire body. (papermasters.com)
  • Diseases of the nervous system can range from the nerve disorder that causes Tourette's to the serious CNS disease of Alzheimer's. (ranker.com)
  • Biomarkers of Alzheimer's Disease: From Central Nervous System to Periphery? (hindawi.com)
  • To receive news and publication updates for International Journal of Alzheimer's Disease, enter your email address in the box below. (hindawi.com)
  • Alzheimer's Disease (AD) is the most frequent form of dementia and represents one of the main causes of disability among older subjects. (hindawi.com)
  • Autopsy data show that neuropathological features of AD are associated with subtle cognitive changes among nondemented subjects, thus suggesting the presence of a "preclinical Alzheimer's disease" [ 1 , 2 ]. (hindawi.com)
  • Currently, the diagnosis of AD is made according to clinical criteria by the National Institute of Neurological and Communicative Disorders and Stroke (NINCDS)-Alzheimer's Disease and Related Disorders Association (ADRDA) [ 4 ], which have limitations in terms of sensitivity and specificity and, above all, do not allow an early diagnosis of the disease. (hindawi.com)
  • Platelets, lymphocytes and erythrocytes from Alzheimer's disease patients: the quest for blood cell-based biomarkers. (eurekaselect.com)
  • Fibrinogen and altered hemostasis in Alzheimer's disease. (eurekaselect.com)
  • Hyperhomocysteinemia exacerbates Alzheimer's disease pathology by way of the β-amyloid fibrinogen interaction. (eurekaselect.com)
  • The diagnostic method is suitable for diagnosis of Alzheimer's disease, brain tumours, general disorders of the cranial circulation, trisomy 21 and Jakob-Creutzfeld syndrome and other degenerative diseases of the central nervous system. (google.com)
  • This article will cover the epigenetics and treatment of Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD). (wikipedia.org)
  • Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. (strandbooks.com)
  • A pathological hallmark of Alzheimer's disease is an accumulation of insoluble plaque containing the amyloid-β peptide of 40-42 amino acid residues 1 . (nature.com)
  • Together, these data imply a high-affinity cell-surface receptor for soluble amyloid-β oligomers on neurons-one that is central to the pathophysiological process in Alzheimer's disease. (nature.com)
  • Thus, PrP C is a mediator of amyloid-β-oligomer-induced synaptic dysfunction, and PrP C -specific pharmaceuticals may have therapeutic potential for Alzheimer's disease. (nature.com)
  • Hardy, J. & Selkoe, D. J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. (nature.com)
  • Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. (nature.com)
  • These specific functions modulate neuronal networks, acting both on resident (neurons, astrocytes, and microglia) as well as circulating immune system cells and the extracellular matrix. (mdpi.com)
  • They found that the response in blood and in skin was the same in 60% of cases.The researchers then generated pluripotent stem cells from fibroblasts of both a VPA responder and a non-responder, and differentiated them into GABAergic neurons (neurons that produce the amino acid GABA, the chief neurotransmitter in the mammalian nervous system). (medindia.net)
  • Prototypic examples are anti- N-methyl-D-aspartate receptor (NMDAR) encephalitis which is induced by an immune response against the NMDAR expressed on neurons or neuromyelitis optica (NMO) in which the disease is induced by antibodies directed against aquaporin-4 expressed on astrocytes. (frontiersin.org)
  • Neurons of the mammalian central nervous system (CNS) are an essential and largely nonrenewable cell population. (asm.org)
  • Neurodengenerative diseases of motor neurons can cause degeneration of motor neurons involved in voluntary muscle control such as muscle contraction and relaxation. (wikipedia.org)
  • The nervous system is a network of neurons (nerve cells) that that sends information to the brain to be analyzed. (bartleby.com)
  • Nervous System and Diseases Within the human anatomy, an intricate and complex network of specialised nerve fibres and neurons works in collaboration with the central nervous system and peripheral system, designed to carry out the various actions humans perform every day. (bartleby.com)
  • second, a dopaminergic cell replacement in an animal model of Parkinson's disease. (springer.com)
  • Occupational exposures and Parkinson's disease mortality in a prospective Dutch cohort. (emf-portal.org)
  • Extremely low-frequency magnetic field exposure, electrical shocks and risk of Parkinson's disease. (emf-portal.org)
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  • Challenges in Differentiating Pediatric Autoimmune CNS Diseases with Similar Clinical and Imaging Phenotypes. (harvard.edu)
  • These mice showed that low levels of vitamin D during development caused increased disease severity through inducing experimental autoimmune encephalomyelitis (EAE). (osu.edu)
  • Strong preclinical data now exist supporting the use of reversible proteasome inhibitors to treat a variety of disease states including cancer, autoimmune and inflammatory diseases, myocardial infarction, and ischemic brain injury. (eurekaselect.com)
  • Our findings reveal that a Th17-ELR + CXC chemokine pathway is critical for granulocyte mobilization, BBB compromise, and the clinical manifestation of autoimmune demyelination in myelin peptide-sensitized mice, and suggest new therapeutic targets for diseases such as MS. (rupress.org)
  • Metabolic and Degenerative Diseases of the Central Nervous System is a comprehensive reference work that provides the neuroscience community with valuable, current, and scholarly summaries on every known degenerative disorder. (elsevier.com)
  • Written by two world-renowned neuropathologists, the book provides an optimal basis for the understanding of metabolic and degenerative diseases of the central nervous system and presents a synthesis that serves the needs of today's investigators in neuropathology, neurology, neuroradiology, neurosurgery, neuropediatrics, general pathology, and geriatrics. (elsevier.com)
  • Metabolic and Degenerative Diseases of the Central Nervous System is intended to provide a sound morphological platform for these forthcoming events. (elsevier.com)
  • Degenerative Diseases of the Cerebral Cortex and White Matter. (elsevier.com)
  • Degenerative Diseases of the Thalamus, the Basal Ganglia, and the Midbrain. (elsevier.com)
  • Degenerative Diseases of the Cerebellum, Brain Stem, and Spinal Cord (Spinocerebellar Degenerations). (elsevier.com)
  • Relation of hereditary optic atrophy (leber) to the other familial degenerative diseases of central nervous system. (semanticscholar.org)
  • Inflammatory disorders of the nervous system, although individually uncommon, collectively make up 10-20% of acute paediatric neurology presentations and many are potentially treatable. (booksiread.org)
  • Huntington's disease is a neurodegenerative genetic disorder that affects muscle coordination and leads to mental decline and behavioral symptoms. (ranker.com)
  • Since 1999, the Huntington's Disease Society of America has committed more than $20 million to fund research, with the goal of finding effective treatments to slow Huntington's disease. (hdsa.org)
  • citation needed] This degeneration is most commonly caused by complications at birth or by Huntington's disease, in addition to rare cases in which the damage may also arise later in life due to stroke or trauma. (wikipedia.org)
  • Central nervous system tuberculosis (TB) was identified in 20 cases of unexplained encephalitis referred to the California Encephalitis Project. (cdc.gov)
  • Infections of the central nervous system include meninigitis (acute and chronic), encephalitis, myelitis, abscesses, and cerebrospinal fluid shunt infections. (oup.com)
  • Probably the most famous prion disease is Bovine Spongiform Encephalitis (mad cow) where the structural change that the prion causes to the proteins in the brain causes holes to appear in the tissue, making it look like a sponge. (answers.com)
  • In treating disease, therapeutic approaches can employ a wide range of targets, but, broadly, these fall into either a cessation of a pathological process, an enhancement of a protective mechanism, or regeneration of damaged tissue. (springer.com)
  • Over the last years it has become clear that many neurological diseases of the central nervous system (CNS) are induced by an adaptive immune response directed against molecules expressed on CNS-resident cells. (frontiersin.org)
  • The role of drug delivery is depicted in the background of various therapies for neurological diseases including drugs in development and the role of special delivery preparations. (digitaljournal.com)
  • Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies. (strandbooks.com)
  • The second edition of OCT and Imaging in Central Nervous System Diseases offers updated state-of-the-art advances using optical coherence tomography (OCT) regrading neuronal loss within the retina. (springer.com)
  • Optical Coherence Tomography in Alzheimer s Disease. (bookmed-reichert.de)
  • Background/aim: To evaluate, in vivo, the optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients with normal-tension glaucoma (NTG) and those with Alzheimer disease (AD) in comparison with healthy subjects. (octnews.org)
  • This disease is a result of the immune system attacking myelin proteins. (bartleby.com)
  • Interactions between the immune and nervous systems are involved in many disease processes. (cambridge.org)
  • The immune system is involved in the pathogenesis of many of these, either by causing tissue damage or alternatively by responding to disease and contributing to repair. (jci.org)
  • However, more information is needed on the ways in which the cells of the immune system interact with the central nervous system (CNS). (clinicaltrials.gov)
  • Objective: The goal of this study is to define the pathophysiological mechanisms underlying the development of disability in immune-mediated disorders of the central nervous system (CNS) and to distinguish these from physiological (and often beneficial) responses of the human immune system to CNS injury. (clinicaltrials.gov)
  • The long-term objective of the study is to acquire knowledge that would allow us to therapeutically inhibit the pathogenic mechanisms and enhance repair mechanisms in immune-mediated CNS diseases, thereby minimizing the extent of CNS tissue damage and promoting recovery. (clinicaltrials.gov)
  • There are many more examples in which it has become clear that a specific adaptive immune response mediated by T or/and B cells is leading to CNS disease. (frontiersin.org)
  • Often the symptoms of the induced disease are not easily interpreted as caused by an immune mediated disease. (frontiersin.org)
  • The research topic includes contributions addressing the target molecules of this group of disorders, the molecular mapping of the relevant epitopes, the analysis of the adaptive immune response (T cell, B cells, antibodies) driving disease, the effector mechanisms such as complement activation cascades, genetic and genomic regulation, as well as environmental triggers. (frontiersin.org)
  • However, immune-mediated lysis of infected cells may not be an optimal strategy for clearance of all virus infections, especially those that involve tissues with little capacity for renewal, such as the central nervous system (CNS) ( 38 , 42 ). (asm.org)
  • This book provides a detailed and comprehensive summary of the childhood diseases that are, or are likely to be, caused by the immune system. (booksiread.org)
  • The cause is unknown, but it may be mediated by the immune system. (wikipedia.org)
  • These data open up a new path for the potential therapeutic use of the agonist/antagonist of these proteins in the management of several central nervous system diseases. (mdpi.com)
  • It can cause several central nervous system diseases. (answers.com)
  • Teva is committed to delivering medicines to meet the needs of patients and families affected by disorders of the Central Nervous System (CNS). (tevapharm.com)
  • A global leader in treatments for disorders of the central nervous system (CNS), Teva provides products to treat patients with neurological and neurodegenerative disorders, pain, and sleep disorders, in various countries around the world. (tevapharm.com)
  • Journal of Central Nervous System Disease is an international, open access, peer-reviewed journal that covers all types of human brain and central nervous system diseases and disorders. (sagepub.com)
  • On the contrast, hypoxic-ischemic encephalopathy is caused by circulatory or respiratory diseases, which results in an insufficient oxygen supply to the brain. (hindawi.com)
  • MindSoothe, a natural herbal remedy, contains a selection of herbs known for their calming and supportive function in maintaining brain and nervous system health, emotional balance and overall wellbeing. (health-cares.net)
  • In ischaemic brain injury, MMPs are implicated in various stages of the disease. (springer.com)
  • Erdheim-Chester disease of the brain: cytological features and differential diagnosis of a challenging case. (springermedizin.at)
  • The present invention is a Anti¬ gene (CNS) with degenerative phenomena of the nervous system associated len zentra¬ and belongs to the class of the heparan sulfate proteoglycans, and on the other hand derived nerve endings from brain, pern directed Antikör¬ and a method for the diagnosis of dysfunctions NEN of the CNS. (google.com)
  • Nanotechnologies can be engineered to cross the BBB, diffuse within the brain tissue, target specific cell or signaling systems, and act as vehicles for delivering therapeutics. (cnm-hopkins.org)
  • Control of brain and nerve diseases : a world-wide challenge. (who.int)
  • This book provides a contemporary resource on one of the major players in retinal diseases - the Retinal Pigment Epithelium (RPE). (springer.com)
  • This book introduces up-to-date knowledge of vitreal and retinal diseases with color fundus illustrations. (springer.com)
  • Find out why we're experts in chronic disease. (prohealth.com)
  • We examined special roles of the Central Nervous System (CNS) in an attempt to resolve the puzzle that chronic diseases cannot be cured by medicine. (preprints.org)
  • We found that chronic diseases are the results of deviated baseline B&C processes. (preprints.org)
  • We further showed that long-term exercises generally push most, if not all, baseline B&C processes in diametrical opposing directions against the diseased B&C processes, implying that exercises play unique roles in reversing chronic diseases. (preprints.org)
  • These diseases are characterized by chronic and progressive neuronal dysfunction, sometimes leading to behavioral abnormalities (as with PD), and, ultimately, neuronal death, resulting in dementia . (wikipedia.org)
  • Included are Creutzfeldt-Jakob Disease, Fatal Familial Insomnia and Kuru in humans plus Scrapie in sheep. (answers.com)
  • Although use of highly active antiretroviral therapy has decreased the severity of AIDS-associated CNS diseases, incidence and persistence of neurologic disease remain prevalent ( 24 ). (jimmunol.org)
  • One must distinguish between neurovirulence, that is, the ability to cause neurologic disease, and neuroinvasiveness, that is, the ability to enter the nervous system. (78stepshealth.us)
  • Peripheral and Autonomic Neuropathies with Involvement of the Central Nervous System. (elsevier.com)
  • We report a case of possible involvement of the central nervous system by the SARS-coronavirus (SARS-CoV). (cdc.gov)
  • While RDD most commonly affects lymph nodes, extranodal involvement of multiple organs has been reported, including the central nervous system (CNS). (ovid.com)
  • CNS involvement and treatment with interferon-alpha are independent prognostic factors in Erdheim-Chester disease: a multicenter survival analysis of 53 patients. (springermedizin.at)
  • Erdheim-Chester disease presenting with cutaneous involvement: a case report and literature review. (springermedizin.at)
  • Cerebral, facial, and orbital involvement in Erdheim-Chester disease: CT and MR imaging findings. (springermedizin.at)
  • CONCLUSION: This analysis of a national diagnostic database provides strong evidence for an association between pediatric CNS demyelinating diseases and psychiatric disorders, and highlights a need for early involvement of mental health professionals. (ox.ac.uk)
  • Immunohistochemical evidence of a cytokine and chemokine network in three patients with Erdheim-Chester disease: implications for pathogenesis. (springermedizin.at)
  • Systemic perturbation of cytokine and chemokine networks in Erdheim-Chester disease: a single-center series of 37 patients. (springermedizin.at)
  • Sections focus on specific categories of diseases, examining the pharmacological, virological, and immunological effects of and on the disease. (booksiread.org)
  • In many other diseases, such as cardiovascular diseases and central nervous system diseases, the vascular endothelium maintains its structural and functional integrity, preventing sufficient drug delivery into the tissue space. (nature.com)
  • Among the reasons for the expansion of these diseases and the appearance of new neuropathogens are globalization, global warming, and the increased proximity between humans and wild animals due to human activities such as deforestation. (cdc.gov)
  • Few reviews of CNS Whipple's disease have delineated the frequencies of abnormalities on neurological examination, cerebrospinal fluid studies, neuroimaging, and intestinal biopsy studies. (nih.gov)
  • MLN- 519 is a small-molecular-weight lactacystin analogue and is being studied for the potential treatment of inflammatory disease and stroke. (eurekaselect.com)
  • Particularly, NME is an idiopathic inflammatory disease of the CNS that is characterized by prominent necrosis and infiltration of inflammatory cells, including lymphocytes, plasma cells, and monocytes or histiocytes into the cerebral cortex and/or white matter, hippocampus, thalamus, and leptomeninges. (biomedcentral.com)
  • This month's journal club covers three papers dealing with stem cells as therapeutic interventions in CNS disease. (springer.com)
  • Only manuscripts of sufficient quality that meet the aims and scope of Journal of Central Nervous System Disease will be reviewed. (sagepub.com)
  • Journal of Wildlife Diseases. (canarydatabase.org)
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Primary melanoma of the central nervous system. (nih.gov)
  • This would be highly valuable in the research setting, as treatments, which are currently under study to potentially interfere with the pathogenetic process of the disease, will probably show their full efficacy only if administered during the prodromal, or even preclinical, phase of AD. (hindawi.com)
  • In the future, genetic engineering is expected to provide effective molecular therapy for the countless diseases currently termed 'metabolic' or 'degenerative. (elsevier.com)
  • This indicates for the first time that response to VPA is the same among blood and skin and suggests that monitoring blood for VPA therapy is indeed feasible in central nervous system diseases", says Dr. Garbes. (medindia.net)
  • Life Science Analytics', Parkinson Disease Therapy Area Pipeline Report contains detailed information on the parkinson disease drug pipeline. (marketpublishers.com)
  • In addition to new developments and disease specific pipeline projects, each report also contains extensive information in tabular format on a company's full product pipeline and products by phase of development with regard to the therapy area. (marketpublishers.com)
  • Gene Therapy for Rare Central Nervous System Diseases Comes to Age. (msdiscovery.org)
  • Circumventing endothelial barrier is, therefore, the key for achieving an adequate, uniform and targeted distribution of therapeutic agents in many critical disease treatments. (nature.com)
  • There is, therefore, an urgent need for a more efficient target delivery approach in many disease treatments. (nature.com)
  • Living with a genetic or rare disease can impact the daily lives of patients and families. (nih.gov)
  • Concurrent culture positive pulmonary disease was found in 4 (50%) of 8 patients tested. (cdc.gov)
  • In this review we present 3 new cases of CNS Whipple's disease and summarize the literature to determine the frequencies of neurological signs and abnormalities on diagnostic testing. (nih.gov)
  • Severe weight loss triggers abnormalities in the endocrine system. (bartleby.com)
  • Unusual Cases of Viral Central Nervous System Disease - Dr. Albert Rovira, from the 2016 Allen D. Leman Swine Conference , September 17-20, 2016, St. Paul, Minnesota, USA. (swinecast.com)
  • The nervous system is also known as the master control unit of the human body, as it operates other major functions such as the circulatory and respiratory systems (Jakab, 2006). (bartleby.com)
  • Paz-Filho G, Licinio J, Wong ML. Pathophysiological basis of cardiovascular disease and depression: a chicken-and-egg dilemma. (eurekaselect.com)
  • The endocrine system uses chemical messengers called hormones that are transported by the circulatory system (blood). (bartleby.com)
  • The circulatory system provides an efficient route for the distribution of blood-borne substances throughout the body. (nature.com)
  • While vaccines are available for many viral and bacterial pathogens, there has been a resurgence of vaccine-preventable diseases in recent years due to under-vaccination of eligible children and adults. (elsevier.com)
  • The Centers for Disease Control and Prevention (CDC) has issued guidelines for diagnosing and treating adverse reactions to smallpox vaccination in the preoutbreak setting. (aafp.org)
  • The ubiquitin-proteasome system (UPS) displays an important quality control function, by removing abnormal proteins from the cytosol, the nucleus and the endoplasmic reticulum. (eurekaselect.com)