Drugs that act principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system. (From Smith and Reynard, Textbook of Pharmacology, 1991, p75)
A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252)
Drugs used for their effects on the respiratory system.
The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.
Drugs that act on neuronal sensory receptors resulting in an increase, decrease, or modification of afferent nerve activity. (From Smith and Reynard, Textbook of Pharmacology, 1991, p367)
Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
The observable response an animal makes to any situation.
A plant genus of the family FABACEAE. The gums and tanning agents obtained from Acacia are called GUM ARABIC. The common name of catechu is more often used for Areca catechu (ARECA).
Passing off as one's own the work of another without credit.
Authors' withdrawal or disavowal of their participation in performing research or writing the results of their study.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
Intentional falsification of scientific data by presentation of fraudulent or incomplete or uncorroborated findings as scientific fact.
Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
A source of inorganic fluoride which is used topically to prevent dental caries.
Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.
Substances that act in the brain stem or spinal cord to produce tonic or clonic convulsions, often by removing normal inhibitory tone. They were formerly used to stimulate respiration or as antidotes to barbiturate overdose. They are now most commonly used as experimental tools.
Induction of a stress reaction in experimental subjects by means of an electrical shock; applies to either convulsive or non-convulsive states.
A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
A chronic, acquired, idiopathic, progressive eruption of the skin that occurs in the context of RENAL FAILURE. It is sometimes accompanied by systemic fibrosis. The pathogenesis seems to be multifactorial, with postulated involvement of circulating fibrocytes. There is a strong association between this disorder and the use of gadolinium-based contrast agents.
Gadolinium. An element of the rare earth family of metals. It has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.
Substances used to allow enhanced visualization of tissues.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.
A series of structurally-related alkaloids that contain the ergoline backbone structure.
A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.
Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
Gases or volatile liquids that vary in the rate at which they induce anesthesia; potency; the degree of circulation, respiratory, or neuromuscular depression they produce; and analgesic effects. Inhalation anesthetics have advantages over intravenous agents in that the depth of anesthesia can be changed rapidly by altering the inhaled concentration. Because of their rapid elimination, any postoperative respiratory depression is of relatively short duration. (From AMA Drug Evaluations Annual, 1994, p173)
A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
A noble gas with the atomic symbol Xe, atomic number 54, and atomic weight 131.30. It is found in the earth's atmosphere and has been used as an anesthetic.
A group of compounds that contain the general formula R-OCH3.
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.
A species of gram-negative bacteria causing mild ANAPLASMOSIS in CATTLE. It also can infect SHEEP and GOATS. It is transmitted by TICKS.

PET and drug research and development. (1/267)

The use of PET to examine the behavioral, therapeutic and toxic properties of drugs and substances of abuse is emerging as a powerful new scientific tool. PET provides a new perspective on drug research by virtue of its ability to directly assess both pharmacokinetic and pharmacodynamic events in humans and in animals. These parameters can be assessed directly in the human body both in healthy volunteers and in patients. Moreover, the new generation of high-resolution, small-animal cameras hold the promise of introducing imaging in the early stages of drug development and make it possible to carry out longitudinal studies in animals and to study genetically altered animals. This places PET in a unique position to contribute significantly to the process of drug development through understanding the molecular mechanisms underlying drug action while addressing some very practical questions such as determining effective drug doses for clinical trials for new drugs, determining the duration of drug action and examining potential drug interactions.  (+info)

Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. (2/267)

Many psychotropic drugs interfere with the reuptake of dopamine, norepinephrine, and serotonin. Transport capacity is regulated by kinase-linked pathways, particularly those involving protein kinase C (PKC), resulting in transporter phosphorylation and sequestration. Phosphorylation and sequestration of the serotonin transporter (SERT) were substantially impacted by ligand occupancy. Ligands that can permeate the transporter, such as serotonin or the amphetamines, prevented PKC-dependent SERT phosphorylation. Nontransported SERT antagonists such as cocaine and antidepressants were permissive for SERT phosphorylation but blocked serotonin effects. PKC-dependent SERT sequestration was also blocked by serotonin. These findings reveal activity-dependent modulation of neurotransmitter reuptake and identify previously unknown consequences of amphetamine, cocaine, and antidepressant action.  (+info)

The prediction and prevention of Alzheimer's disease--towards a research agenda. (3/267)

This paper sets a research agenda for the prediction and prevention of future onset of Alzheimer's disease (AD). From a MEDLINE review of the literature, the authors found age to be a predictor of AD. The literature also indicates that memory and attentional impairments predict AD, although the relative risk is relatively low. Late-onset depression may also predict AD, but these data are limited by a lack of cohort studies. Studying cognitively impaired subjects with late-onset depression may identify a high-risk group, facilitating prevention trials. Characteristics of an "ideal" preventive agent are suggested. There is a biologic rationale, and preliminary evidence, that non-steroidal anti-inflammatory drugs (including ASA), estrogen and vitamin E may play a preventive role in AD. Other compounds (such as acetylcholinesterase inhibitors) are also promising, but costs, side effects, and lack of other health benefits may preclude their use in all but very high-risk groups.  (+info)

American ginseng extract reduces scopolamine-induced amnesia in a spatial learning task. (4/267)

OBJECTIVE: To determine if HT-1001, an extract of American ginseng, affects scopolamine-induced memory and performance deficits in a spatial learning task, alters brain concentrations of aminergic neurotransmitters, and alters choline uptake in synaptosome preparations. DESIGN: Animal study. ANIMALS: 48 Sprague Dawley rats. INTERVENTIONS: Long-term oral administration of a test material or control solution. Intraperitoneal administration of scopolamine (2 mg/kg) 30 minutes before testing. OUTCOME MEASURES: Performance on Morris water maze task, choline uptake, aminergic neurotransmitter analysis, in vitro monoamine oxidase analysis (of compounds). RESULTS: HT-1001 protected against scopolamine-induced amnesia and increased choline uptake in synaptosomal preparations. HT-1001 did not alter brain concentrations of norepinephrine, dopamine, 5-HT (serotonin), 3,4-dihydroxyphenylacetic acid or 5-hydroxyindoleactic acid. HT-1001 had a very weak ability to inhibit monoamine oxidase activity in vitro. CONCLUSIONS: HT-1001 demonstrates a capacity to protect against scopolamine-induced memory deficits.  (+info)

Synthesis of new derivatives of 1-alkyl-2-aryl-1H-2,3-dihydroimidazo[1,2-a]pyrimidin-5-one active in CNS. Part 2. Synthesis and results of preliminary pharmacological screening of 7-(substituted)amino-1-alkyl-2-aryl-1H-2,3-dihydroimidazo[1,2-a]pyrimid in-5- ones. (5/267)

Synthesis of new 7-(substituted)amino-1-alkyl-2-aryl-1H-2,3-dihydroimidazo[1,2-a]py rimidin-5- ones bearing the 4-arylpiperazin-1-yl moiety connected by ethyl or acetoyl two-carbonyl chain extension was described. The arylpiperazinyl moiety was introduced by alkylation or acylation with corresponding halogeno-derivatives. Preliminary pharmacological screening showed the 7-(substituted)-amino derivatives of the system investigated to exhibit the CNS activity lesser than that of the 7-amino derivatives and to have no effect on the serotonin neurotransmission pathway.  (+info)

Synthesis and biological activity of BIS-1,2,4-triazole and BIS-1,3,4-thiadiazole derivatives. (6/267)

Synthesis of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives via the condensation of N'-substituted amidrazones and p-phenylenediisothiocyanate (PPD) is presented. The reaction conditions are discussed. Results of a preliminary pharmacological screening are presented.  (+info)

A novel activation of Ca(2+)-activated Cl(-) channel in Xenopus oocytes by Ginseng saponins: evidence for the involvement of phospholipase C and intracellular Ca(2+) mobilization. (7/267)

1. The signal transduction mechanism of ginsenosides, the active ingredients of ginseng, was studied in Xenopus oocytes using two-electrode voltage-clamp technique. Ginseng total saponin (GTS), i.e., an unfractionated mixture of ginsenosides produced a large outward current at membrane potentials more positive than -20 mV when it was applied to the exterior of oocytes, but not when injected intracellularly. The effect of GTS was concentration-dependent (EC(50): 4.4 microg ml(-1)) and reversible. 2. Certain fractionated ginsenosides (Rb(1), Rb(2), Rc, Rf, Rg(2) and Ro) also produced an outward current in a concentration-dependent manner with the order of potency of Rf>Ro>Rb(1)=Rb(2)>Rg(2)>Rc. Other ginsenosides (Rd, Re and Rg(1)) had little or no effect. 3. The GTS effect was completely blocked by bath application of the Ca(2+)-activated Cl(-) channel blocker niflumic acid and by intracellular injection of the calcium chelator BAPTA or the IP(3) receptor antagonist heparin. Also, the effect was partially blocked by bath-applied U-73122, a phospholipase C (PLC) inhibitor and by intracellularly injected GTP gamma S, a non-hydrolyzable GTP analogue. Whereas, it was not altered by pertussin toxin (PTX) pretreatment. 4. These results indicate that: (1) interaction of ginsenosides with membrane component(s) at the extracellular side leads to Ca(2+)-activated Cl(-) channel opening in Xenopus oocyte membrane; and (2) this process involves PLC activation, the release of Ca(2+) from the IP(3)-sensitive intracellular store and PTX-insensitive G protein activation.  (+info)

G alpha(q/11) coupled to mammalian phospholipase C beta 3-like enzyme mediates the ginsenoside effect on Ca(2+)-activated Cl(-) current in the Xenopus oocyte. (8/267)

Recently we demonstrated that ginsenosides, the active ingredients of Panax ginseng, enhanced Ca(2+)-activated Cl(-) current in the Xenopus oocyte through a signal transduction mechanism involving the activation of pertussis toxin-insensitive G protein and phospholipase C (PLC). However, it has not yet been determined precisely which G protein subunit(s) and which PLC isoform(s) participate in the ginsenoside signaling. To provide answers to these questions, we investigated the changes in ginsenoside effect on the Cl(-) current after intraoocyte injections of the cRNAs coding various G protein subunits, a regulator of G protein signaling (RGS2), and G beta gamma-binding proteins. In addition, we examined which of mammalian PLC beta 1-3 antibodies injected into the oocyte inhibited the action of ginsenosides on the Cl(-) current. Injection of G alpha(q) or G alpha(11) cRNA increased the basal Cl(-) current recorded 48 h after, and it further prevented ginsenosides from enhancing the Cl(-) current, whereas G alpha(i2) and G alpha(oA) cRNA injection had no significant effect. The changes following G alpha(q) cRNA injection were prevented when G beta(1)gamma(2) and G alpha(q) subunits were co-expressed by simultaneous injection of the cRNAs coding these subunits. Injection of cRNA coding G alpha(q)Q209L, a constitutively active mutant that does not bind to G beta gamma, produced effects similar to those of G alpha(q) cRNA injection. The effects of G alpha(q)Q209L cRNA injection, however, were not prevented by co-injection of G beta(1)gamma(2) cRNA. Injection of the cRNA coding RGS2, which interacts most selectively with G alpha(q/11) among various identified RGS isoforms and stimulates the hydrolysis of GTP to GDP in active GTP-bound G alpha subunit, resulted in a severe attenuation of ginsenoside effect on the Cl(-) current. Finally, antibodies against PLC beta 3, but not -beta 1 and -beta 2, markedly attenuated the ginsenoside effect examined at 3-h postinjection. These results suggest that G alpha(q/11) coupled to mammalian PLC beta 3-like enzyme mediates ginsenoside effect on Ca(2+)-activated Cl(-) current in the Xenopus oocyte.  (+info)

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Other nervous system drugs | Other nervous system drugs Brokerage service for pharmaceutical and parapharmaceutical products active ingredients and precursors..
Global Central Nervous System Drugs Market Report by The Business Research Company is segmented as Analgesics, Anti-Parkinson drugs, Anesthetics, Anti-Epileptics
TY - JOUR. T1 - Adverse drug reactions reported by consumers for nervous system medications in Europe 2007 to 2011. AU - Aagaard, Lise. AU - Hansen, Ebba Holme. PY - 2013/6. Y1 - 2013/6. U2 - 10.1186/2050-6511-14-30. DO - 10.1186/2050-6511-14-30. M3 - Journal article. VL - 14. SP - 30. JO - BMC Pharmacology and Toxicology. JF - BMC Pharmacology and Toxicology. SN - 1472-6904. ER - ...
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This drug pipelines features 6 companies, including Abeona Therapeutics Inc, Amicus Therapeutics Inc, Exicure Inc, Circumvent Pharmaceuticals Inc, Blue Turtle Bio Technologies Inc
Find Digestive System Drugs & Medicines manufacturer, Digestive System Drugs & Medicines supplier, Digestive System Drugs & Medicines exporter and Digestive System Drugs & Medicines wholesaler online in India. Call morelife LONDON on +91-
Frontiers in CNS Drug Discovery is an eBook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to all pharmaceutical scientists involved in research in CNS drug design and discovery. Each volume is devoted to the major advances in CNS drug design and discovery. The eBook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.. ...
Frontiers in CNS Drug Discovery is an eBook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to all pharmaceutical scientists involved in research in CNS drug design and discovery. Each volume is devoted to the major advances in CNS drug design and discovery. The eBook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.. ...
J. T. Hanlon, R. M. Boudreau, Y. F. Roumani, A. B. Newman, C. M. Ruby, R. M. Wright, S. N. Hilmer, R. I. Shorr, D. C. Bauer, E. M. Simonsick, S. A. Studenski, Number and Dosage of Central Nervous System Medications on Recurrent Falls in Community Elders: The Health, Aging and Body Composition Study, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2009, 64A, 4, ...
In hospitals, the nursing staff is often confronted with the problem of the preparation and administration of drugs for their pediatric patients because of the lack of indication, pediatric dosage, and appropriate galenic form. The goal of this study was to give an overview of the nurses preparation habits in pediatric units and highlight their daily problems. This single-center prospective study was conducted through an observation of the nursing staff during the drug preparation process in medicine, surgery and intensive care units. We included 91 patients (55 boys and 36 girls), with an average age of 6.3 years (youngest child, 10 days old; oldest child, 18 years old). We observed a mean 2.16 drug preparations per patient [1-5]. We collected 197 observation reports regarding 66 injectable drugs and 131 oral drugs (71 liquid forms and 60 solid forms). The majority of these reports concerned central nervous system drugs (63/197), metabolism and digestive system drugs (50/197), and ...
aOrientation to medications -- Principles of drug action -- Measurement and dosage calculations -- Administering parenteral medications -- Medication therapy -- Vitamins, minerals, and herbs -- Antibiotics, antifungals, and antivirals -- Drugs for the eye and ear -- Drugs for the skin -- Drugs for the cardiovascular system -- Drugs for the respiratory system -- Drugs for the gastrointestinal system -- Drugs for the urinary system and fluid balance -- Drugs for the reproductive system -- Drugs for the endocrine system -- Drugs for the musculoskeletal system -- Drugs for the nervous and sensory systems -- Psychotropic drugs -- Antineoplastic drugs -- Drugs for the pediatric patient -- Drugs for the older adult patient ...
Respiratory system drugs is a term used to describe a wide variety of medicines used to relieve, treat, or prevent respiratory diseases such as asthma, chronic bronchitis, chronic obstructive pulmonary disease (COPD), or pneumonia. Today, Ddu, the leading global pharmaceutical & medical device B2B online platform, will share Chinas Import and Export Market Report of Respiratory System Drugs with you.
[101 Pages Report] Check for Discount on Global Endocrine System Drug Market Professional Survey Report 2017 report by QYResearch Group. This report studies Endocrine System Drug in Global market, especially...
Clinilabs is a global, full-service CRO dedicated to providing a full range of CNS drug development services to pharmaceutical and biotechnology companies, from first-in-human to Phase 3 trials. ...
Causation is unknown and treatments are limited for most of the 600 diseases in the CNS...CNS drug development is badly in need of innovative approaches.
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Carbazole is an aromatic heterocyclic organic compound. It has a tricyclic structure, consisting of two six-membered benzene rings fused on either side of a five-membered nitrogen-containing ring. The compounds structure is based on the indole structure, but in which a second benzene ring is fused onto the five-membered ring at the 2-3 position of indole (equivalent to the 9a-4a double bond in carbazole, respectively ...
This template is within the scope of WikiProject Pharmacology, a collaborative effort to improve the coverage of Pharmacology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks ...
Overactivity of the multidrug efflux transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) is believed to play an important role in resistance to central nervous system drug treatment. (R)-[11C]verapamil (VPM) PET can be used to measure the function of P-gp at the BBB, but low brain uptake of VPM hampers the mapping of regional differences in cerebral P-gp function and expression. The aim of this study was to evaluate the dose-response relationship of two potent P-gp inhibitors and to investigate if increased brain uptake of VPM mediated by P-gp inhibition can be used to assess regional differences in P-gp activity. Two groups of Sprague-Dawley rats (n = 12) underwent single VPM PET scans at 120 min after administration of different doses of the P-gp inhibitors tariquidar and elacridar. In an additional six rats, paired VPM PET scans were performed before and after administration of 3 mg/kg tariquidar. Inhibitor administration resulted in an up to 11-fold increase in VPM brain distribution
Last week on January 20, 2011, the FDAs Peripheral and Central Nervous System Drugs Advisory Committee decided not to recommend approval of Lillys Amyvid™ (florbetapir) in a 13:3 vote. Florbetapir is an imaging agent used with Positron Emission Tomography (PET) to show accumulation of beta-amyloid plaque in the brain. I previously wrote about Lillys acquisition of Avid Radiopharmaceuticals for florbetapir on this blog.. This imaging approach aids in the early detection of Alzheimers disease, as a negative scan, not showing any beta-amyloid plaque, would rule out Alzheimers disease. Given that it is currently, hard to distinguish age related memory less and different types of dementia, diagnostic imaging tools have an important role to play.. The FDA advisory committees decision would probably have come as a surprise to Lilly, since the clinical trial data showed clear efficacy and no safety concerns. While the committee rejected immediate approval, they did recommend approval (16:0), ...
All medications a patient is taking, including complementary and non-prescription drugs, must be accurately ascertained. Limited evidence suggests the brown paper bag method of asking patients (or carers) to physically bring all medicines with them to the clinical encounter is the best way to reconcile medications. Asking specific questions to detect non-adherence also helps identify drugs which may be ceased.. Patients at highest risk of ADRs are those prescribed the greatest number of drugs (up to 82% risk with seven drugs or more11) or which include high-risk drugs (antithrombotic agents, insulin, oral hypoglycaemic agents, cardiovascular and central nervous system drugs). Clinicians need to look for pre-existing drug toxicity presenting as falls, confusion and lethargy, effects too often inappropriately attributed to ageing.. Estimating a patients life expectancy is important in determining the goals of care and potential long-term value of many preventive medications. Patients with a ...
Todays action follows a March 8, 2006 unanimous recommendation by the FDAs Peripheral and Central Nervous System Drugs Advisory Committee to allow the reintroduction of Natalizumab. TOUCH (TYSABRI [Natalizumab] Outreach: Unified Commitment to Health) Prescribing Program was developed in conjunction with the FDA to facilitate the appropriate use of Natalizumab and to assess, on an ongoing basis, the incidence and risk factors for PML and other serious opportunistic infections associated with Natalizumab treatment. This program represents Biogen Idec and Elans commitment to making the unique benefits of Natalizumab available in a responsible manner. Elements of the TOUCH Prescribing Program include revised labeling with a prominent boxed warning of the risk of PML; and warnings against concurrent use of Natalizumab with chronic immunosuppressant or immunomodulatory therapies, and patients who are immunocompromised due to HIV, hematological malignancies, organ transplants or immunosuppressive ...
Johnson Chemical Pharmaceutical Works Co Ltd operates in the Pharmaceutical Preparations sector. Johnson Chemical Pharmaceutical Works Co., Ltd. is principally engaged in the manufacturing and distribution of western medicines and the related raw materials. The Companys medicine products mainly include solid dosage forms and liquor dosage forms. Its solid dosage forms include soft and hard capsules, sugar coated tablets, film-coated tablets, suppositories, powder, granules and tablets, among others. The Companys products portfolio includes central nervous system drugs, hormones and hormone function medicines, respiratory medicines, gastrointestinal drugs, vitamins and others.
Markets Covered: 1) By Type: Pharmaceutical Drugs; Biologics. 2) By Distribution Channel: Supermarkets/Hypermarkets; Convenience Stores; E-Commerce; Others. 3) By Nature: Organic; Conventional. Subsegments Covered: Cardiovascular Drugs; Dermatology Drugs; Gastrointestinal Drugs; Genito-Urinary Drugs; Hematology Drugs; Anti-Infective Drugs; Metabolic Disorders Drugs; Musculoskeletal Disorders Drugs; Central Nervous System Drugs; Oncology Drugs; Ophthalmology Drugs; Respiratory Diseases Drugs; Monoclonal Antibodies (MAbS); Therapeutic Proteins; Vaccines. Companies Mentioned: Pfizer; F. Hoffmann-La Roche Ltd; Sanofi; Johnson & Johnson; Merck & Co.. Metrics Covered: Number of Enterprises; Number of Employees. Countries: Argentina; Australia; Austria; Belgium; Brazil; Canada; Chile; China; Colombia; Czech Republic; Denmark; Egypt; Finland; France; Germany; Hong Kong; India; Indonesia; Ireland; Israel; Italy; Japan; Malaysia; Mexico; Netherlands; New Zealand; Nigeria; Norway; Peru; Philippines; ...
PDF Deerfield, Ill. - April 20, 2017 Baxter International Inc. (NYSE: BAX), a leader in innovative technology for medication delivery, today announced a new, comprehensive guide to building a smart infusion system drug library. The guide is available now on the website of the Institute for Safe Medication Practices (ISMP)-the leading medication safety organization-at www.ISMP.org.. Drug libraries help clinicians identify potential infusion errors before they harm patients by checking the pumps programming against a curated list of medications and fluids and their medically appropriate dose ranges. If programming exceeds drug library limits, smart pumps will alert clinicians.. A carefully built drug library is critical for the safe and effective use of any smart infusion system. This publication guides comprehensive drug library development and integration with an electronic health record, and is designed to advance infusion safety in all hospitals regardless of infusion system, said guide ...
PDF Deerfield, Ill. - April 20, 2017 Baxter International Inc. (NYSE: BAX), a leader in innovative technology for medication delivery, today announced a new, comprehensive guide to building a smart infusion system drug library. The guide is available now on the website of the Institute for Safe Medication Practices (ISMP)-the leading medication safety organization-at www.ISMP.org.. Drug libraries help clinicians identify potential infusion errors before they harm patients by checking the pumps programming against a curated list of medications and fluids and their medically appropriate dose ranges. If programming exceeds drug library limits, smart pumps will alert clinicians.. A carefully built drug library is critical for the safe and effective use of any smart infusion system. This publication guides comprehensive drug library development and integration with an electronic health record, and is designed to advance infusion safety in all hospitals regardless of infusion system, said guide ...
Research Report on Asia-Pacific Endocrine System Drug Market Report 2017. The Report includes market price, demand, trends, size, Share, Growth, Forecast, Analysis & Overview.
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A respiratory system drug applicator for a patient is disclosed which may include a number of features to enhance the administration of the aerosolized drug to the patient. For instance, an adjustable flow regulator may be utilized which regulates the air flow during inhalation by the patient (during which the aerosolized drug is also administered to the patients respiratory system), and thus affects the patients breathing pattern. Moreover, a distensible drug reservoir which changes shape during inhalation and exhalation by the patient may be utilized. This may be used to provide biofeedback to the patient regarding the patients breathing pattern.
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This webinar will focus on studies of neurotransmitter-activated ion channels as well as GABAA, NMDA, and nicotinic acetylcholine receptors, in that they are validated therapeutic targets in several neurological disorders.
Following the success of last years event, SMi will be bringing together leading industry experts to explore the current and future opportunities within CNS drug development. Representing the second largest therapeutic segment of the pharmaceutical market it is also one of the fastest growing. This year SMis conference aims to cover preclinical drug discovery activity as well as effective CNS drug development strategies and problems encountered in clinical trials, with in-depth discussions and case study presentations from the key industry players including, Johnson & Johnson, Eli Lilly and Novartis.. As CNS therapies become more complex and difficult to bring to market, the need to consider issues involved in effective trial design is increasingly important. Key issues include discussion on clinical research- the preclinical to clinical interface; clinical trials in disease specific therapeutics (with a focus on Alzheimers, Multiple Sclerosis, Pain, Anxiety, ADHD and Sleep disorders); ...
Despite enormous advances in CNS research, CNS disorders remain the worlds leading cause of disability. This accounts for more hospitalizations and prolonged care than almost all other diseases combined, and indicates a high unmet need for good CNS drugs and drug therapies. Following dosing, not only the chemical properties of the drug and blood-brain barrier (BBB) transport, but also many other processes will ultimately determine brain target site kinetics and consequently the CNS effects. The rate and extent of all these processes are regulated dynamically, and thus condition dependent. Therefore, heterogenious conditions such as species, gender, genetic background, tissue, age, diet, disease, drug treatment etc., result in considerable inter-individual and intra-individual variation, often encountered in CNS drug therapy. For effective therapy, drugs should access the CNS
禿頭藥品。第一章 神經係統藥物 (Drugs Acting on the Nervous System) 第一節 疼痛緩解劑 (Drugs used for Relief of pain) (A) 鎮痛劑 (Analgesics) a. 麻醉性鎮痛劑 (Narcotics) 藥品名稱: Morphine inj 處置代碼: MORP3 規格單位: 10mg/1ml, Amp.。找到了禿頭藥品相關的熱門資訊。
On behalf of the over 700 Rexall Pharma Plus pharmacists located in communities all across Ontario, we support the Ontario government in its efforts to expand access to essential health services and increase immunization rates across the province, which results in healthier communities and lower overall healthcare costs, Scorpiniti stated.. Pharmacists will now be able to provide additional services to patients, such as renewals and adaptations of existing prescriptions; prescribing medication to help people quit smoking; demonstrating how to use an asthma inhaler or inject insulin; chronic disease monitoring; and the administration of flu shots.. With flu season just around the corner, this announcement is particularly timely, as Ontarians now have the ability to receive flu shots in the pharmacy.. Rexall is committed to making it easy for Ontarians to feel good about their health. We have invested in training and infrastructure to ensure we are ready to make it easier to receive the flu shot ...
Baxter International Inc. (NYSE: BAX), a leader in innovative technology for medication delivery, today announced a new, comprehensive guide to buildi
symbol is not intended to imply any federal safety rating of the carrier pursuant to 49 USC 31144. Readers should not draw conclusions about a carriers overall safety condition simply based on the data displayed in this system. Unless a motor carrier in the SMS has received an UNSATISFACTORY safety rating pursuant to 49 CFR Part 385, or has otherwise been ordered to discontinue operations by the FMCSA, it is authorized to operate on the nations roadways. Motor carrier safety ratings are available at http://safer.fmcsa.dot.gov and motor carrier licensing and insurance status are available at http://li-public.fmcsa.dot.gov/. ...
There s no evidence to support the notion that people who get the flu vaccine every year somehow weaken their immune system over time, researchers say. In fact,
There are over 200 FDA-approved CNS drugs. It may take a while, but we plan to catalog and describe them as best we can in terms of medicinal chemistry features and any interesting drug discovery aspects we find and can learn from.. Alphabetically speaking, it will begin with Acamprosate, and after a quick look at its sulfonic acid structure, one might not think it even capable of crossing the blood-brain-barrier at all. Its pKa is less than -1, and the sweet spot for brain penetration is a pKa of between 4 and 10. A strong acid (e.g., pKa ,4), or a strong base for that matter (pKa ,10), will be fully ionized at physiological pH, and these compounds rarely penetrate the BBB (to a significant extent).. ​Guidelines limiting the pKa of a compound to between 4 and 10 for a CNS compound have been suggested; see Fischer, H., Gottschlich, R., Seelig, A. (1998). Blood-brain barrier permeation: molecular parameters governing passive diffusion. J. Membrane Biol. 165, 201-211.. ​Furthermore, the ...
CNS disorders remain the world s leading cause of disability. Currently, no cures are present, which indicates a high unmet need for good CNS drugs and drug th...
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According to be able to recent analyses, the traditional vial-to-syringe method is one of typically the major causes of occupational exposures to dangerous drugs. Sometimes the vials can end up being over pressurized that will direct to seapage and splatters. If Marijuana in your System plus leaks are unnoticed, they can significantly contaminate the atmosphere and will become very dangerous to the workers and typically the patients from the healthcare configurations.. In the development of medicines, a few hazardous medications are used that can result in health and fitness complications for often the staff involved in all varieties of drug related exercises. The closed system medication transfer devices are often the engineered safety units the fact that lower the risks of exposures to be able to dangerous drugs. All these programs present complete safety towards the workers and often the staff which might be engaged throughout reconstitution and copy regarding drugs. These safety gadgets have ...
Showcase of recent assignments:. SVP, Clinical Development & Medical Affairs (CDMA) & Chief Medical Officer for a US headquartered global pharmaceutical company, primarily developing innovative medicines for the treatment of CNS diseases. The company has a diversified product portfolio and a substantial clinical pipeline for chronic diseases including schizophrenia, depression, addiction and multiple sclerosis.. Project Leader, CNS Drug Discovery for a global drug discovery alliance and development partnership company, working specifically within a collaboration dedicated to developing therapies that slow the progression of Huntingtons disease.. Business Unit Lead, Multiple Sclerosis for the Danish subsidiary of a global healthcare leader with a presence in over 100 countries. With a direct report to the General Manager, the client was seeking a Business Unit Lead for the multiple sclerosis franchise in which it has two lead products.. Principal Scientist CNS Research for the CNS Diseases ...
The worlds expanding, aging population means diseases of the central nervous system, like Alzheimers and Parkinsons, are potential blockbuster areas for innovative pharma and biotech companies that are able to navigate clinical studies and get to market. Scrip looks at five emerging trends that are likely to affect the CNS drug development landscape in 2018. ...
Project Summary AbstractThere exists a dire need for new and more effective drugs to treat disorders of the central nervous systemCNSespecially in mental healthThe pace of approval for new chemical entities is anemicwith an average of just three compounds per year entering the market over the lastyearsUnsurprisinglyclinical trial failure rates for CNS drug development remain greater thanand many m .... ...
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The key therapeutic topic renin-angiotensin system drugs: dual therapy has been retired from the 2017 update of medicines optimisation: key therapeutic topics. The version published in 2016 is available here for information but it has not been updated since February 2016. Like all the other key therapeutic topics it is not formal NICE guidance. ...
Central Nervous System Agents. 2 (3): 175-186. doi:10.2174/1568015023357978. Betz, A.L.; Goldstein, G.W. "Brain capillaries: ... Begley, D.J. (1996). "The blood-brain barrier: principles for targeting peptides and drugs to the central nervous system". J. ... structure and function". In Lajtha, A. (ed.). Structural Elements of the Nervous System; Handbook of Neurochemistry, Vol. 7. ... One approach is the design of soft drugs (SDs), new, active therapeutic agents, often isosteric or isolelectronic analogs of a ...
Central nervous system (CNS) seizure agents. CNS seizure agents inhibit cellular signaling by acting as receptor antagonists. ... This results in continued nerve impulses across the synapses, which eventually cause nerve system damage. Examples of AChE ... Examples of CNS seizure agents are organochlorine pesticides. Respiratory blockers. These are toxicants that affect respiration ...
Central Nervous System seizure agents are associated with effects such as partial or whole body seizures and coughing. Dioxin ... 4. Central Nervous System Seizure Agent". Environmental Toxicology and Chemistry. 10 (1): 115-131. doi:10.1002/etc.5620100113. ... In the last experiment, central nervous system seizure agents were analyzed. These included an acetylcholinesterase inhibitor, ... central nervous system seizure agents, and uncouplers of oxidative phosphorylation. Acetylcholinesterase, an enzyme which ...
... actions and metabolism in the central nervous system". Central Nervous System Agents in Medicinal Chemistry. 12 (3): 189-216. ... It is also seen as a potential therapeutic agent for spinal cord injury (SCI); in low doses (10 mg/kg) it was seen to be ... In a test of phase shifted circadian cycle, TIK-301 showed efficacy in readjusting phase shifts in all physiological systems. ... Doghramji K (August 2007). "Melatonin and its receptors: a new class of sleep-promoting agents". Journal of Clinical Sleep ...
Central Nervous System Agents in Medicinal Chemistry. 9 (3): 197-204. doi:10.2174/1871524910909030197. PMID 20021354. Kobayashi ... A class of compounds with a novel profile of central nervous system activity". Journal of Medicinal Chemistry. 16 (9): 1003-11 ... it inhibits neuronal reuptake of serotonin and potentiates serotonergic activity in the central nervous system. It does not ... The American Society of Health-System Pharmacists. Retrieved 8 January 2018. Hoskins M, Pearce J, Bethell A, Dankova L, Barbui ...
Central Nervous System Agents in Medicinal Chemistry. 9 (3): 197-204. doi:10.2174/1871524910909030197. PMID 20021354. ... Journal of Central Nervous System Disease. 3: 51-65. doi:10.4137/JCNSD.S1611. PMC 3663615. PMID 23861638. Anttila AK, Rasanen L ... Silver H (2001). "Fluvoxamine as an adjunctive agent in schizophrenia". CNS Drug Reviews. 7 (3): 283-304. doi:10.1111/j.1527- ... Coquoz D, Porchet HC, Dayer P (September 1993). "Central analgesic effects of desipramine, fluvoxamine, and moclobemide after ...
Current Medicinal Chemistry-Central Nervous System Agents. 1 (2): 155-170. doi:10.2174/1568015013358536. Harel M, Schalk I, ... In the central nervous system it is associated with PRiMA which stands for Proline Rich Membrane anchor to form symmetric form ... Koelle GB (1954). "The histochemical localization of cholinesterases in the central nervous system of the rat". Journal of ... and are used to treat of a range of central nervous system diseases. Tetrahydroaminoacridine (THA) and donepezil are FDA- ...
Central Nervous System Agents in Medicinal Chemistry. 10 (4): 298-309. doi:10.2174/187152410793429746. PMID 20868357.. ... Nerve agents such as sarin, which were developed as chemical weapons, produce convulsions as a major part of their toxidrome, ... de Araujo Furtado M, Rossetti F, Chanda S, Yourick D (December 2012). "Exposure to nerve agents: from status epilepticus to ...
Central Nervous System Agents in Medicinal Chemistry. 10 (3): 218-237. doi:10.2174/1871524911006030218. PMID 20557283.CS1 maint ... The plant is native to Central and South America, and the Caribbean, a species characteristic of Montane cloud forests (in ...
Central Nervous System Agents in Medicinal Chemistry. 10 (3): 218-237. doi:10.2174/1871524911006030218. PMID 20557283 - via www ... central nervous system damage and death in sheep. Arundo donax, 0.0057% DMT in dried rhizome, no stem, 0.026% bufotenine, ...
Amongst analgesics there are a small number of agents which act on the central nervous system but not on the opioid receptor ... Central Nervous System Agents in Medicinal Chemistry. 9 (3): 172-83. doi:10.2174/1871524910909030172. PMID 20021351. Mitra S ( ... Vella-Brincat J, Macleod AD (2007). "Adverse effects of opioids on the central nervous systems of palliative care patients". ... They are found principally in the central and peripheral nervous system and the gastrointestinal tract. These receptors mediate ...
... and the central nervous system". Central Nervous System Agents in Medicinal Chemistry. 12 (3): 233-9. doi:10.2174/ ... Caldwell MD, Hu SS, Viswanathan S, Bradshaw H, Kelly ME, Straiker A (June 2013). "A GPR18-based signalling system regulates IOP ...
"Effects of snake venom polypeptides on central nervous system". Central Nervous System Agents in Medicinal Chemistry. 12 (4): ... Hemotoxic venom acts on the cardiovascular system, including the heart and blood. Neurotoxic venom acts on the nervous system, ... its action on the nervous system is not great, no individual group of nerve-cells appears to be picked out, and the effect upon ... is mainly on the nervous system, respiratory paralysis being quickly produced by bringing the venom into contact with the ...
Central Nervous System Agents in Medicinal Chemistry. 17 (3). doi:10.2174/1871524917666170717113524. ISSN 1871-5249. Sigstad, ...
Central Nervous System Agents in Medicinal Chemistry. 13 (3): 166-94. doi:10.2174/1871524913666140109113341. PMID 24450388. Two ... Brodal P (2016). "Chapter 5: Neurotransmitters and their receptors". The Central Nervous System. Oxford University Press. p. 75 ... Trendelenburg U (1991). "The interaction of transport mechanisms and intracellular enzymes in metabolizing systems". Journal of ...
Central Nervous System Agents in Medicinal Chemistry. 10 (3): 180-206. doi:10.2174/1871524911006030180. hdl:10261/61750. PMID ... a central nervous system stimulant. "Adzenys XR-ODT". United States Food and Drug Administration. Retrieved 7 March 2016. " ... but dextroamphetamine is a more potent central nervous system stimulant. Although it is effective in reducing primary ADHD ... While an effective agent for managing the symptoms, the development of liver failure in 14 cases over the next 27 years would ...
CIBA Foundation Symposium (30 April 2008). Novel Infectious Agents and the Central Nervous System. John Wiley & Sons. p. 61. ...
For the central nervous system[edit]. Drugs affecting the central nervous system include: Psychedelics, hypnotics, anaesthetics ... For the reproductive system or urinary system[edit]. antifungal, alkalinizing agents, quinolones, antibiotics, cholinergics, ... An elaborate and widely used classification system is the Anatomical Therapeutic Chemical Classification System (ATC system). ... An elaborate and widely used classification system is the Anatomical Therapeutic Chemical Classification System (ATC system). ...
... and the central nervous system". Central Nervous System Agents in Medicinal Chemistry. 12 (3): 233-239. doi:10.2174/ ...
Nath researches the effects of HIV and other infectious agents on the central nervous system. Amyotrophic lateral sclerosis ( ... At NINDS, Nath also leads the Section of Infections of the Nervous System and plans to institute a translational research ...
Despite the availability of antifungal agents, aspergillosis in the central nervous system carries a poor prognosis. Though ... However, in patients with suppressed immune systems, or if introduced directly into the spinal column, the fungus can be deadly ...
August 1999). "AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury". ...
The most studied chemotheraputic agent in PCNSL is methotrexate (a folate analogue that interferes with DNA repair). ... Central. nervous system. Encephalitis/. meningitis. DNA virus. JCV Progressive multifocal leukoencephalopathy. RNA virus. MeV ... A primary central nervous system lymphoma (PCNSL), also known as microglioma and primary brain lymphoma,[1] is a primary ... Fine HA, Mayer RJ (December 1993). "Primary central nervous system lymphoma". Ann. Intern. Med. 119 (11): 1093-104. doi:10.7326 ...
Current Medicinal Chemistry Central Nervous System Agents. 1 (2): 155-170. doi:10.2174/1568015013358536.. Šablon:Closed access ... Autonomic and Somatic Nervous Systems in Netter's Illustrated Pharmacology. Elsevier Health Science. str. 43. ISBN 978-1-929007 ... Tripathi A (October 2008). "Acetylcholinsterase: A Versatile Enzyme of Nervous System". Annals of Neuroscience 15 (4). ...
Patients on Amantadine should avoid combination with other central nervous system (CNS) depressing agents, such as alcohol. ... Due to its effects on the central nervous system, it should not be combined with additional CNS stimulants or anticholinergic ... Amantadine may affect the central nervous system due to dopaminergic and anticholinergic properties. The mechanisms of action ... Amantadine was approved by the U.S. Food and Drug Administration in October 1968, as a prophylactic agent against Asian (H2N2) ...
Kim, EJ; Shin, WH (2005). "General pharmacology of CKD-732, a new anticancer agent: effects on central nervous, cardiovascular ... and respiratory system". Biological & Pharmaceutical Bulletin. 28 (2): 217-23. doi:10.1248/bpb.28.217. PMID 15684472. "Zafgen ...
"Are North American Bunyamwera serogroup viruses etiologic agents of human congenital defects of the central nervous system?". ... Tensaw virus has been isolated from mosquitoes in southwest Alabama, southeast Georgia, and central and south Florida. Host ...
... is a central nervous system stimulant and nootropic agent belonging to the racetam family of drugs. It is marketed ...
... agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system. These ... Possible effects in the central nervous system resemble those associated with delirium, and may include: Confusion ... are divided into three categories in accordance with their specific targets in the central and peripheral nervous system: ... Several are depolarizing agents. Examples of common anticholinergics: Antimuscarinic agents Atropine Benztropine (Cogentin) ...
Agarwala SS, Kirkwood JM (2000). "Temozolomide, a novel alkylating agent with activity in the central nervous system, may ... If the cancer has central nervous system involvement, or with meningeal disease, intrathecal chemotherapy may be administered.[ ... Available agents[edit]. Main article: List of antineoplastic agents. There is an extensive list of antineoplastic agents. ... Alkylating agents[edit]. Main article: Alkylating antineoplastic agent. Alkylating agents are the oldest group of ...
... central nervous system or the respiratory tract,[12] you may speak of a syndromic form of craniosynostosis. More than 180 ... On the other hand, a recent evaluation of valproic acid (an anti-epilepticum), which has been implicated as a causative agent, ... Blount JP, Louis RG, Tubbs RS, Grant JH (October 2007). "Pansynostosis: a review". Child's Nervous System. 23 (10): 1103-9. doi ... Renier D, Lajeunie E, Arnaud E, Marchac D (November 2000). "Management of craniosynostoses". Child's Nervous System. 16 (10-11 ...
... so it affects the central nervous system, although its effects are qualitatively distinct relative to those of ... functioning as a selective norepinephrine releasing agent (with few or no effects on the release of dopamine), ... Central side effects may include anxiety, insomnia, and anorexia (loss of appetite).[citation needed] ...
... and inappropriate regulation of metabolism by the central nervous system.[10] However, not all people with insulin resistance ... A second oral agent of another class or insulin may be added if metformin is not sufficient after three months.[87] Other ... nervous system activity, or hormonal factors that may lead to diabetes.[34] ... "In Lee M (ed.). Basic Skills in Interpreting Laboratory Data (5th ed.). Bethesda, MD: American Society of Health-System ...
central nervous system development. • chloride transport. • ion transmembrane transport. • signal transduction. • chemical ... Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At ...
Nervous system. *Perinatal asphyxia. *Periventricular leukomalacia. Musculoskeletal. *Gray baby syndrome. *muscle tone * ... Other agents causing ophthalmia neonatorum include Herpes simplex virus (HSV 2), Staphylococcus aureus, Streptococcus ... Ocular ischemic syndrome / Central retinal vein occlusion. *Central retinal artery occlusion. *Branch retinal artery occlusion ...
... peripheral nervous system, and central nervous system.[61][84] Many of the signs and symptoms of Lyme disease are a consequence ... After the identification of B. burgdorferi as the causative agent of Lyme disease, antibiotics were selected for testing, ... Tryptophan, a precursor to serotonin, appears to be reduced within the central nervous system in a number of infectious ... they confirm a diagnosis of central nervous system (CNS) neuroborreliosis if positive, but do not exclude it if negative.[112] ...
Central nervous system. *Intracerebral. *Intrathecal. *Epidural. Circulatory,. musculoskeletal. *Intravenous. *Intracardiac. * ... Gases and other drugs used in anaesthesia include oxygen, nitrous oxide, helium, xenon, volatile anaesthetic agents. Medication ...
... and poisons the central nervous system,[219] which is dangerous as the required dosage of lithium to treat bipolar disorder is ... KC8 is a very strong reducing agent and is pyrophoric and explodes on contact with water.[114][115] While the larger alkali ... In the Solar SystemEdit. Estimated abundances of the chemical elements in the Solar system. Hydrogen and helium are most common ... In both the old IUPAC and the CAS systems for group numbering, this group is known as group IA (pronounced as "group one A", as ...
Of numerous grading systems in use for the classification of tumor of the central nervous system, the World Health Organization ... Contrast agent uptake, sometimes in characteristic patterns, can be demonstrated on either CT or MRI scans in most malignant ... WHO classification of the tumors of the central nervous system. Anaplastic astrocytoma, Astrocytoma, Central neurocytoma, ... The central nervous system cancer survival rate in children is approximately 60%. The rate varies with the type of cancer and ...
Neurosteroids are synthesized in the central nervous system (CNS) and the peripheral nervous system (PNS) from cholesterol and ... Sedative actions of benzodiazepines limit their usefulness as analgesic agents and they are therefore generally not considered ... Baulieu EE (1997). "Neurosteroids: of the nervous system, by the nervous system, for the nervous system". Recent Progress in ... GABA is a major inhibitory neurotransmitter in the central nervous system. Upon binding, it triggers the GABAA receptor to open ...
... the human brain and nervous system). Philosophical models of mind are divided into physical and non-physical expositions. ... The agent is assumed power to intervene in the physical world.[74][75][76][77][78][79][80][81] Agent (substance)-causal ... it is plausible that the central loci of our responsibility are our choices, or "willings".. ... Agent/substance-causal theories[edit]. Agent/substance-causal accounts of incompatibilist free will rely upon substance dualism ...
It is probably due to the genetic morphology of the immune system. Another possible side effect is an infection of the nervous ... Five genotypes (Angola, Central/East Africa, East Africa, West Africa I, and West Africa II) occur only in Africa. West Africa ... A local doctor concluded that some unspecified infectious agent had arrived in a package from New Orleans.[74][75] 650 ... From there, they reach the haemocoel (the blood system of mosquitoes) and from there the salivary glands. When the mosquito ...
... has good penetration across the blood brain barrier with peak plasma levels within the central nervous system ... Tikal K, Hrabánková M (June 1993). "[Indications for antidepressive agents in relation to diseases of the cardiovascular system ... 1998). "cAMP-dependent phosphorylation system after short and long-term administration of moclobemide". J Psychiatr Res. 32 (2 ... Coquoz D, Porchet HC, Dayer P (September 1993). "Central analgesic effects of desipramine, fluvoxamine, and moclobemide after ...
... due to damage of the central nervous system), aphasia (defect in expression causing distorted speech), or language ... the potential for harm from exposure to particular agents, the accuracy of diagnostic tests, and the predictive power of ... The rise of an understanding of the body and mind in terms of the nervous system led to the emergence of a new wave of music ... After 1800 books on music therapy often drew on the Brunonian system of medicine, arguing that the stimulation of the nerves ...
Central nervous system. *Intracerebral. *Intrathecal. *Epidural. Circulatory, musculoskeletal. *Intravenous. *Intracardiac. * ... "Chamomile: an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity" ...
Cells in the central nervous system (astrocytes) include MAO-B that oxidizes MPTP to 1-methyl-4-phenylpyridinium (MPP+), which ... Therefore, because of sulfa drugs' competitive inhibition, they are excellent antibacterial agents. An example of competitive ... We can therefore set up a system of equations:. [. E. ]. 0. =. [. E. ]. +. [. ES. ]. +. [. EI. ]. {\displaystyle {\ce {[E]_{0 ... As with the derivation of the Michaelis-Menten equation, assume that the system is at steady-state, i.e. the concentration of ...
Central. nervous system. Encephalitis/. meningitis. DNA virus. JCV Progressive multifocal leukoencephalopathy. RNA virus. MeV ... The JCV virus may also be a causative agent of aseptic meningitis (JCVM), as JCV was the only pathogen identified in the CSF of ... JCV can cross the blood-brain barrier into the central nervous system, where it infects oligodendrocytes and astrocytes, ... JCV found in the central nervous system of PML patients almost invariably have differences in promoter sequence to the JCV ...
... of pre-synaptic α2 receptors facilitates the release of several neurotransmitters in the central and peripheral nervous system ... "Yohimbine pharmacokinetics and interaction with the sympathetic nervous system in normal volunteers". European Journal of ... Yohimbe (Pausinystalia johimbe) is a tree that grows in western and central Africa;[25] yohimbine was named as originally ... Rao MR, Palada MC, Becker BN (2013). "Medicinal and aromatic plants in agroforestry systems". In Nain PK, Rao MR, Buck LE (eds ...
Monoamine releasing agents. *Substituted amphetamines. *Nervous system drug stubs. Hidden categories: *Drugs with non-standard ... This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.. *v ... Instead, it may act as a serotonin and/or norepinephrine releasing agent.[citation needed] ... Triggle, D. J. (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall / CRC. ISBN 0-412-46630-9.. .mw-parser- ...
... bind to dopaminergic receptors in the central nervous system.[39][72][73] Isotretinoin may affect dopaminergic ... Reproductive system and breast disorders *Sexual dysfunction, including erectile dysfunction and decreased libido ... Drugdex system, vol. 128. Greenwood Village (CO): Thomson Micromedex; 2006.[page needed] ... Isotretinoin is also thought to affect the serotonergic system - it increases expression of 5-HT1A receptors in the pre- ...
... of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system". ... An SOD-mimetic agent, TEMPOL, is currently in clinical trials for radioprotection and to prevent radiation-induced dermatitis.[ ... In biological systems, this means that its main reactions are with itself (dismutation) or with another biological radical such ...
In the central nervous system (CNS), the major mediators of the symptoms of anxiety disorders appear to be norepinephrine, ... "CDC - The Emergency Response Safety and Health Database: Systemic Agent: BENZENE - NIOSH". www.cdc.gov. Archived from the ... Peripherally, the autonomic nervous system, especially the sympathetic nervous system, mediates many of the symptoms. Increased ... stimulating the HPA Axis and sympathetic nervous system) and hippocampus (which is implicated in emotional memory along with ...
Many more specialized disciplines have emerged in recent years, e.g. neurochemistry the chemical study of the nervous system ( ... Chemistry: The Central Science. Prentice Hall; 8 edition (1999). ISBN 0-13-010310-1. pp. 3-4. ... Substances that have the ability to oxidize other substances are said to be oxidative and are known as oxidizing agents, ... and modifying the nervous system.. *Nuclear chemistry is the study of how subatomic particles come together and make nuclei. ...
The system was based on the existing counties (now known as the historic counties, since the major boundary changes of 1974). ... The king became increasingly nervous about the possibility of his daughter Mary inheriting the throne, as England's one ... During this breakdown of central authority, nobles built adulterine castles (i.e. castles erected without government permission ... presumably by agents of Isabella and Mortimer. ... The system was based on the existing counties (today known as ...
In African trypanosomiasis it is used for early disease before central nervous system involvement, as a second line option to ... However, these may increase with severe kidney problems.[20] Pentamidine can remain in the system for as long as 8 months after ... "The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 3 December 2016.. ... Neurological: Dizziness, drowsiness, neuralgia, confusion, hallucinations, seizures and other central side effects are reported ...
... helps remove infectious agents.[2] Also, mucus traps infectious agents.[2] The gut flora can prevent the colonization of ... but dendritic cells are not connected to the nervous system. Dendritic cells are very important in the process of antigen ... Type I interferons (IFN), secreted mainly by dendritic cells,[22] play a central role in antiviral host defense and a cell's ... Complement system[edit]. Main article: Complement system. The complement system is a biochemical cascade of the immune system ...
Luft BJ, Chua A (2000). "Central Nervous System Toxoplasmosis in HIV Pathogenesis, Diagnosis, and Therapy". Curr. Infect. Dis. ... 53.0 53.1 Coovadia H (2004). "Antiretroviral agents-how best to protect infants from HIV and save their mothers from AIDS". N. ... 2002). "Guidelines for using antiretroviral agents among HIV-infected adults and adolescents". Ann. Intern. Med. 137 (5 Pt 2): ... World Health Organization (1990). "Interim proposal for a WHO staging system for HIV infection and disease". WHO Wkly Epidem. ...
... is not surprising that what goes on in my mind affects and is affected by what goes on in my brain and central nervous system. ... Please feel free... I agree this is unclear: "consciousness is sufficiently described neurophysiological agents".. I'm troubled ... Breuer is talking to the operational reality of performing measurements on a quantum system which includes the observing system ... it doesn't appear to address a system like the brain or imply anything important regarding the analysis of a brain-like system. ...
... particularly the central nervous system, it is called a germinoma.[3] ... Modern radiotherapy techniques as well as one or two cycles of single-agent carboplatin have been shown to reduce the risk of ... Tumors of the male urogenital system (C60-C63/D29, 185-187/222) ...
Central nervous system. *Intracerebral. *Intrathecal. *Epidural. Circulatory, musculoskeletal. *Intravenous. *Intracardiac. * ... most commonly a vesicant or chemotherapeutic agent, in which case it is called extravasation and extensive necrosis can occur.[ ... Main article: Central venous catheter. Central IV lines have their catheters that are advanced through a vein and empty into a ... While some central lines have their catheter pass through the skin and then directly into the vein, other central lines called ...
Central Nervous System Agents. 2 (3): 175-186. doi:10.2174/1568015023357978. Betz, A.L.; Goldstein, G.W. "Brain capillaries: ... Begley, D.J. (1996). "The blood-brain barrier: principles for targeting peptides and drugs to the central nervous system". J. ... structure and function". In Lajtha, A. (ed.). Structural Elements of the Nervous System; Handbook of Neurochemistry, Vol. 7. ... One approach is the design of soft drugs (SDs), new, active therapeutic agents, often isosteric or isolelectronic analogs of a ...
Central nervous system (CNS) seizure agents. CNS seizure agents inhibit cellular signaling by acting as receptor antagonists. ... This results in continued nerve impulses across the synapses, which eventually cause nerve system damage. Examples of AChE ... Examples of CNS seizure agents are organochlorine pesticides. Respiratory blockers. These are toxicants that affect respiration ...
4. CENTRAL NERVOUS SYSTEM AGENTS. 5. ANTI-INFLAMMATORY AGENTS. 6. ADRENERGIC AGENTS. 7. ANTI-ANXIETY AGENTS. 8. ANTI-BACTERIAL ... ANTIDEPRESSIVE AGENTS. 18. ANTI-HIV AGENTS. 19. CARDIOVASCULAR AGENTS. 20. ANTI-ARRHYTHMIA AGENTS. ... AGENTS. 9. ANTICONVULSANTS. 10. ENZYME INHIBITORS. 11. ADJUVANTS, IMMUNOLOGIC. 12. ANALGESICS, OPIOID. 13. ANESTHETICS. 14. ... ANTI-ASTHMATIC AGENTS. 15. NARCOTICS. 16. ANALGESICS, NON-NARCOTIC. 17. ...
Rugo noted that data were expected late this year - as well as evidence of activity of the agent in the central nervous system ... every three weeks in combination with one of four chemotherapy agents (capecitabine, eribulin, gemcitabine or vinorelbine) ...
SPS 160.02(25) (25) "Substance" means a psychoactive agent or chemical which principally affects the central nervous system and ... SPS 160.02(21)(f) (f) Promoting healthy support systems in families, schools, workplaces and communities. ... means education on the comprehensive process of collecting pertinent data about patients or patient systems and their ...
SPS 160.02(25) (25) "Substance" means a psychoactive agent or chemical which principally affects the central nervous system and ... SPS 160.02(21)(f) (f) Promoting healthy support systems in families, schools, workplaces and communities. ... means education on the comprehensive process of collecting pertinent data about patients or patient systems and their ...
SPS 160.02(25) (25) "Substance" means a psychoactive agent or chemical which principally affects the central nervous system and ... SPS 160.02(21)(f) (f) Promoting healthy support systems in families, schools, workplaces and communities. ... means education on the comprehensive process of collecting pertinent data about patients or patient systems and their ...
ANTI-EPILEPTIC AGENT [EPC],DECREASED CENTRAL NERVOUS SYSTEM DISORGANIZED ELECTRICAL ACTIVITY [PE] ...
Therapeutic Class: Central Nervous System Agent Commonly used Brand names associated with Razadyne ER and its equivalents in ...
Central Nervous System Agents in Medicinal Chemistry Most Downloaded Article(s). *Targeting the JAK/STAT Signaling Pathway for ... Synthesis and Biological Evaluation of a New Series of Benzothiazole-Benzothiadiazine Conjugates as Antibacterial Agents. ...
Health Benefits: Central Nervous System Agent. Supporting Link(s):. https://pubchem.ncbi.nlm.nih.gov/compound/4-aminopyridine# ...
CENTRAL NERVOUS SYSTEM AGENTS * Therapeutic Class: PSYCHOTHERAPEUTIC AGENTS * Product Category: Hospital Unit Dose ...
CENTRAL NERVOUS SYSTEM AGENTS * Therapeutic Class: ANALGESICS AND ANTIPYRETICS * Product Category: Hospital Unit Dose ...
Central nervous system agents f.. Is ivermectin prescription in canada. Has been honing its ability to save wounded troops with ...
Central nervous system agents (CNS) prescriptions: Treating parts of the nervous system, such as the brain, and includes pain ... AAA East Central. All Rights Reserved. AAA East Central is a member club affiliated with the American Automobile Association ( ... AAA East Central is a not-for-profit association with 80 local offices in Kentucky, New York, Ohio, Pennsylvania and West ... Twitter RT @TRIP_Inc: Investment in the Interstate Highway System should be increased from $23 billion in 2018 to $57 billion ...
Blood Formation, Coagulation, and Thrombosis Agents (90) * 24. Cardiovascular Drugs (209) * 28. Central Nervous System Agents ( ...
Central Nervous System Agents in Medicinal Chemistry. Volume. 19. Issue. 2. DOI. https://doi.org/10.2174/ ... important biological compounds that warrant further investigation for their development as possible therapeutic agents. From an ...
Central Nervous System Agents in Medicinal Chemistry *Antiviral Natural Products Against Chronic Hepatitis B: Recent ... Anti-Cancer Agents in Medicinal Chemistry. * Neuroprotection by Natural Polyphenols: Molecular Mechanisms. ... Type 2 Diabetes and its Impact on the Immune System. Current Diabetes Reviews ... for anti-Cancer Gene Therapy of Glioma Cells Using a Third Generation Self-Inactivating Lentiviral Vector System in Combination ...
Drugs That Affect the Cardiovascular System • Drugs That Act on the Central Nervous System •Chemotherapeutic Agents • Drugs ... For this reason, authors Holland, Adams, and Brice have organized Core Concepts in Pharmacology according to body systems and ... 313 Pharmaceutics-1 Ansels Pharmaceutical Dosage Forms and Drug Delivery Systems. 3. ABC of Rheumatology 5th Edition pdf ... That Affect the Endocrine System • Miscellaneous Drugs If you are in need of a timesaving,stress-reducing approach to learning ...
Agents inhibiting the effect of narcotics on the central nervous system. Descriptor ID. D009292 ... Peripheral Nervous System Agents [D27.505.696.663]. *Sensory System Agents [D27.505.696.663.850] ... Bone Density Conservation Agents. *Central Nervous System Depressants. *Central Nervous System Stimulants ...
... to improve testing methods and to extend our understanding of how drugs modulate specific cognitive processes at the systems or ... Brain, Brain Diseases, Central Nervous System Agents, Cognition, Humans, Individuality, Neurotransmitter Agents ... to improve testing methods and to extend our understanding of how drugs modulate specific cognitive processes at the systems or ...
Some toxic agents have adverse effects on the central nervous system (CNS). Non-contrast computed tomography (CT) of the brain ... psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain ... psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain ... psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain ...
... as well as agents to evaluate other aspects of normal and abnormal function in the central nervous system using PET imaging ... This work led to the development of a new class of radiopharmaceutical agents, among which is Pittsburgh Compound-B, to non- ... Mathis focused primarily on the development of radiotracers to image the serotonin and dopamine neuroreceptor systems, ...
Remote appointments cannot be used to renew or issue central nervous system (CNS) agent prescriptions or prescriptions for ... All doctors need to sign in to the patient information and operating systems with their personal ID cards. ...
Calcium and Magnesium: these are natural relaxing agents for the central nervous system. Many headache sufferers are deficient ... the relaxation response to promote deep tranquility and balance and engages the rest and restore parasympathetic nervous system ... Identifying the cause of headaches is one of the central challenges that all practitioners face. In particular, migraine ...
Central Nervous System Agents in Medicinal Chemistry ... Child Abuse Research in South Africa ... Chinese Journal of Physiology ... Cardiovascular & Hematological Agents in Medicinal Chemistry * Cardiovascular & Hematological (Haematological) ...
Noopept - is considered to be a nootropic agent stimulating in the central nervous system. Its unique properties lead to an ... It supports the regeneration of the nervous system. Therefore, it is best to take this remedy before bedtime or rest.. ... Hupercine A is one of the most desirable substances in the group of agents that provide so-called brain doping. It allows you ... The amazing, proprietary blend of Insane Nitric Oxide System increases the amount of nitric oxide in the body, bringing with it ...
Levodopa is a central nervous system agent that converts to dopamine in the brain; carbidopa is a decarboxylase inhibitor that ... Levodopa is a central nervous system agent that converts to dopamine in the brain; carbidopa is a decarboxylase inhibitor that ...
Health Topics/Central Nervous System Agent/Pharmacology/Anticonvulsant. When should I call my doctor if I am taking Potiga?. ...
Nano-neuroparticulate agents: high central nervous system (CNS) aggregation lead/carbon-silicate nanofibers (network disrupters ... explained how neuroscience has made huge leaps by using technology to study and understand how the nervous system is structured ... neurovascular hemorrhagic agents (for in-close and population use as "stroke epidemic" induction agents).. These capabilities ... Pharmaceuticals and organic neurotoxins (i.e., ultra-low dose/high specify agents for use in targeting diplomatic/local culture ...
Central Nervous System Agents. Psychotropic Drugs. Therapeutic Uses Eukaryota. Pharmacologic Actions Chemical Actions and Uses ... HALLUCINOGENIC OR PSYCHOTOMIMETIC AGENTS: WHAT ARE THEY?; Chapter II: THE BOTANICAL DISTRIBUTION OF HALLUCINOGENS; Chapter III ...
  • In terms of categories, central nervous system agents , including analgesics, were most commonly inquired about, representing 21. (freethesaurus.com)
  • 3. Analgesics, Narcotic antagonists, and agents used to treat arthritis: Agents used to treat gout. (worldcat.org)
  • Prescription drugs that act on the central nervous system (CNS)-e.g. opioids, benzodiazepines, stimulants-are associated with various adverse effects, including cognitive and psychomotor impairments. (iwh.on.ca)
  • These include a class of drugs which effect the central nervous system. (avivadirectory.com)
  • A need a power point with a general review of the Central nervous system following a description of central nervious drugs including: classification of central nervous system drugs, their class, mode of action, indication, contraindication, side effects and commercial names. (essaypass.net)
  • This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes. (biomedcentral.com)
  • ASTA Medica AG is a 900 million dollar a year company with leading products in the fields of anticancer drugs, central nervous system agents , and respiratory therapies. (freethesaurus.com)
  • A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system. (ebi.ac.uk)
  • Whereas historically drugs such as heroin and cocaine have been considered the "dangerous" drugs, in recent years, prescription drug abuse has far surpassed "illegal" drugs as agents of lethal drug toxicity. (medscape.com)
  • Some commonly used pesticides (for example, the organophosphate (OP) Malathion and the carbamate Sevin) and some common therapeutic drugs (the carbamates pyridostigmine [Mestinon] and physostigmine [Antilirium]) also inhibit acetylcholinesterase and can be considered 'nerve agents. (fas.org)
  • The new drugs thus designed achieve selective organ and/or therapeutic site drug targeting and produce safe therapeutic agents and safe environmental chemicals. (wikipedia.org)
  • One approach is the design of soft drugs (SDs), new, active therapeutic agents, often isosteric or isolelectronic analogs of a lead compound, with a chemical structure specifically designed to allow predictable metabolism into inactive metabolites after exerting their desired therapeutic effect(s). (wikipedia.org)
  • The central nervous system (CNS) contains both types of receptors, but the pharmacology in the CNS is more complex and less well understood. (fas.org)
  • We are good quality supplier of Pharmaceutical Intermediates, Central Nervous System Agents Sex enhancement from China. (providepharmacy.com)
  • Bulk central nervous system agents , cardiovascular agents, humanized monoclonal antibodies for breast, ovarian and prostate cancer, along with thiazolidine-dione antidiabetic agents and anti-infective agents are expected to be in the most demand. (freethesaurus.com)
  • Anti-Infective Agents in Medicinal Chemistry was launched in 2002 and later renamed in 2010 as Anti-Infective Agents. (benthamscience.com)
  • While maintaining 1 MAC of one of those agents, nitrous oxide was again administered in the same previous concentrations. (scielo.br)
  • Likewise, the penetration of foscarnet into the central nervous system has been evaluated only from single determinations in cerebrospinal fluid (CSF) and single ratios of concentrations in CSF to concentrations in plasma in samples obtained at variable and arbitrary intervals from patients with nonuniform dosages. (asm.org)
  • Higher concentrations are central to innate immunity, but if unchecked this cytokine orchestrates much chronic and acute disease, both infectious and noninfectious. (hindawi.com)
  • These agents were dissolved into tissue culture media at various concentrations. (who.int)
  • Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. (biomedcentral.com)
  • Intranasal delivery does not necessarily require any modification to therapeutic agents. (biomedcentral.com)
  • The blood-brain barrier (BBB) restricts the use of numerous therapeutic agents that have been developed to treat memory loss and neurodegeneration because it limits CNS penetration, depending on drug size or charge. (biomedcentral.com)
  • Therapeutic Agents for Alsheimer's Disease", Curr. (freepatentsonline.com)
  • Since their introduction in the early 1980s, CDSs have also generated considerable research work, especially for brain and eye targeting of various therapeutic agents, including those that cannot cross the blood-brain barrier or the blood-retinal barrier on their own. (wikipedia.org)
  • Gadavist is the sixth gadolinium-based contrast agent (GBCA) approved by the FDA for use in patients undergoing magnetic resonance imaging of the central nervous system. (healthcanal.com)
  • Guerbet's Dotarem has the distinction of becoming the seventh gadolinium-based contrast agent approved by the FDA for patients undergoing central nervous system-related MRI exams. (fiercebiotech.com)
  • Outlines the various central nervous system stimulants and their affects on attention deficits, with or without hyperactivity. (avivadirectory.com)
  • Nerve agents are organophosphorous cholinesterase inhibitors. (fas.org)
  • Methodology: Applying microwave excitation for generation of hydrazide groups within the structure of small molecule carboxylic acids, five agents were prepared for evaluation of bacterial growth inhibition. (who.int)
  • Article contains a simplified, layman's definition of anticonvulsants, including information about various different agents of this group and the possible adverse reactions and side effects that may be pertinent. (avivadirectory.com)
  • 5. Gastrointestinal agents: Agents used to treat acid peptic disorders. (worldcat.org)
  • Central and peripheral nervous system toxicity of common chemotherapeutic agents. (nature.com)
  • Central nervous system medications treat various medical conditions such as alzheimer's disease, depression and parkinson's disease. (sharecare.com)
  • A wide variety of therapeutics, including both small molecules and macromolecules, can be targeted to the olfactory system and connected memory areas affected by Alzheimer's disease. (biomedcentral.com)
  • Using the intranasal delivery system, researchers have reversed neurodegeneration and rescued memory in a transgenic mouse model of Alzheimer's disease. (biomedcentral.com)
  • TNF neutralization by biological therapy (i.e., by in vitro biologically generated specific anti-TNF agents) has become an enormous success story in a number of chronic inflammatory diseases outside the brain but curiously has not yet been taken seriously enough by the relevant medical specialists for its possible widespread adoption to be objectively examined for the chronic neuroinflammatory disease states. (hindawi.com)
  • Mortality from invasive fungal disease involving the central nervous system (CNS) is excessive. (liverpoolwttc.org.uk)
  • Recent evidence suggests that in addition to the JC virus (the other member of the same family known to be strongly neurotropic and responsible for the progressive multifocal leukoencephalopathy ), BK virus can infect and cause clinically relevant disease in the human central nervous system . (bvsalud.org)
  • The combination of levodopa and carbidopa is used to treat the symptoms of Parkinson's disease and Parkinson's-like symptoms that may develop after encephalitis (swelling of the brain) or injury to the nervous system caused by carbon monoxide poisoning or manganese poisoning. (medlineplus.gov)
  • Dextromethorphan is in a class of medications called central nervous system agents. (medlineplus.gov)
  • Many pharmacological agents may induce a variety of movement disorders, including dystonia, tremor, parkinsonism, myoclonus and dyskinesia, with an acute, subacute or more chronic time course. (nih.gov)
  • Berkhout B. Infectious diseases of the nervous system: pathogenesis and worldwide impact. (medscape.com)
  • Multi-target agents for the treatment of multi-factorial diseases. (nyit.edu)
  • It can cause several central nervous system diseases. (answers.com)
  • Meningitis infectious agents are spread most often through which pathway to the central nervous system (CNS)? (medscape.com)
  • WHO HQ Library catalog › Details for: Novel infectious agents and the central nervous system. (who.int)
  • Novel infectious agents and the central nervous system. (who.int)
  • This study may help identify how abnormalities in brain systems that control the ability to ignore irrelevant information may contribute to the development of depression in older adults. (clinicaltrials.gov)
  • The injectable agent helps radiologists spot brain and spinal abnormalities. (fiercebiotech.com)
  • A pivotal clinical trial helped turn the tide toward U.S. approval: 245 adult and 38 pediatric patients as young as age 2 with suspected central nervous system abnormalities each received a baseline MRI minus Dotarem, and then another MRI with the Dotarem injection. (fiercebiotech.com)
  • To present evidence that these compounds will penetrate into the central nervous system. (who.int)
  • However, the agent can be removed from the enzyme and the enzyme 'reactivated' by several types of compounds, the most useful of which are the oximes. (fas.org)
  • Drug-induced movement disorders share a number of features that should make them easy to identify, including a clear temporal relationship between medication initiation and symptom onset, a dose-effect, and, with the exception of tardive syndromes, complete resolution after discontinuation of the offending agent. (nih.gov)
  • Jaijakul S, Arias CA, Hossain M, Arduino RC, Wootton SH, Hasbun R. Toscana meningoencephalitis: a comparison to other viral central nervous system infections. (medscape.com)
  • IMSEAR at SEARO: Novel Tuberculostatic Agents Suitable for Treatment of Mycobacterium tuberculosis Infections of the Central Nervous System. (who.int)
  • Bartzatt Ronald, Sule Preeti, Cirillo Suat L G, Cirillo Jeffrey D. Novel Tuberculostatic Agents Suitable for Treatment of Mycobacterium tuberculosis Infections of the Central Nervous System. (who.int)
  • A special focus is given to alert clinicians to the possibility of this association during the differential diagnosis of infections of the central nervous system in the immunocompromised host . (bvsalud.org)
  • Antimicrobial agents including antituberculosis (anti-TB) agents are the most common cause of idiosyncratic drug-induced liver injury (DILI) and drug-induced liver failure across the world. (qxmd.com)
  • Central Nervous Systems Agents -- analysis -- congresses. (powells.com)
  • It provides contrast-enhanced imaging of the central nervous system, helping to detect and visualize lesions that disrupt the cell barrier that normally separates the brain from the blood stream. (healthcanal.com)
  • Gadavist MRI scans improved the visualization of lesions in the central nervous system when compared to MRI scans without contrast," said Libero Marzella, M.D., acting division director, Division of Medical Imaging Products in the FDA's Center for Drug Evaluation and Research. (healthcanal.com)
  • In addition, their physicochemical properties are shown to allow high levels of penetration into the central nervous system. (who.int)
  • Gold nanoparticle s (GNPs) possess unique physicochemical properties that may facilitate entry into the central nervous system (CNS) where they may act therapeutically. (cdc.gov)
  • After acute exposure to a nerve agent, the erythrocyte enzyme activity most closely reflects the activity of the tissue enzyme, but during recovery the plasma enzyme activity more closely parallels tissue enzyme activity. (fas.org)
  • For most nerve agents the aging time is longer than the time within which acute casualties will be seen. (fas.org)
  • Bulk central nervous system agents demand will benefit from advances in a number of therapies. (freethesaurus.com)
  • The next-highest classes were anti-dementia agents 1.5 (1.5-1.6), antipsychotics 1.5 (1.4-1.6), anti-Parkinson agents 1.3 (1.2-1.5), and antidepressants 1.1 (1.1-1.2). (czeek.com)
  • Nerve agents inhibit acetylcholinesterase in tissue, and their effects are caused by the resulting excess acetylcholine. (fas.org)
  • CNS seizure agents inhibit cellular signaling by acting as receptor antagonists. (wikipedia.org)
  • However, while the OP pesticides cause the same biological effects as nerve agents, there are some important differences in the duration of biological activity and response to therapy. (fas.org)
  • Having various levels of tuberculostatic agents, then tuberculosis bacteria were added to determine level of growth inhibition. (who.int)
  • This decrease was also observed when nitrous oxide was used as a coadjuvant agent, however without clinical significance. (scielo.br)
  • The clinical effects from nerve agent exposure are caused by excess acetylcholine. (fas.org)
  • The beneficial agent may be in either or both of controlled release dosage form or non-controlled release dosage form and may be one or more of nutrients, medicaments, probiotics, electrolytes, rehydration solutions and diagnostic agents, to which a flavoring agent may be added. (google.com)
  • They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. (harvard.edu)
  • HESHUN is one of the leading China trauma implant, joint replacement, orthopedic drill and saw, spine system manufacturers and suppliers. (china-jinshu.com)