The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.
Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)
A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252)
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
MYCOSES of the brain, spinal cord, and meninges which may result in ENCEPHALITIS; MENINGITIS, FUNGAL; MYELITIS; BRAIN ABSCESS; and EPIDURAL ABSCESS. Certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME).
Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)
Characteristic properties and processes of the NERVOUS SYSTEM as a whole or with reference to the peripheral or the CENTRAL NERVOUS SYSTEM.
The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Bacterial infections of the brain, spinal cord, and meninges, including infections involving the perimeningeal spaces.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Tuberculosis of the brain, spinal cord, or meninges (TUBERCULOSIS, MENINGEAL), most often caused by MYCOBACTERIUM TUBERCULOSIS and rarely by MYCOBACTERIUM BOVIS. The infection may be limited to the nervous system or coexist in other organs (e.g., TUBERCULOSIS, PULMONARY). The organism tends to seed the meninges causing a diffuse meningitis and leads to the formation of TUBERCULOMA, which may occur within the brain, spinal cord, or perimeningeal spaces. Tuberculous involvement of the vertebral column (TUBERCULOSIS, SPINAL) may result in nerve root or spinal cord compression. (From Adams et al., Principles of Neurology, 6th ed, pp717-20)
Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.
Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of TOGAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.
An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
Elements of limited time intervals, contributing to particular results or situations.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Injections into the cerebral ventricles.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.
Renewal or physiological repair of damaged nerve tissue.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Annelids of the class Hirudinea. Some species, the bloodsuckers, may become temporarily parasitic upon animals, including man. Medicinal leeches (HIRUDO MEDICINALIS) have been used therapeutically for drawing blood since ancient times.
An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Central nervous system vasculitis that is associated with SYSTEMIC LUPUS ERYTHEMATOSUS. Clinical manifestations may include DEMENTIA; SEIZURES; CRANIAL NERVE DISEASES; HEMIPARESIS; BLINDNESS; DYSPHASIA; and other neurological disorders.
An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.
Refers to animals in the period of time just after birth.
Clusters of multipolar neurons surrounded by a capsule of loosely organized CONNECTIVE TISSUE located outside the CENTRAL NERVOUS SYSTEM.
The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)
Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.
Infections of the brain, spinal cord, or meninges by single celled organisms of the former subkingdom known as protozoa. The central nervous system may be the primary or secondary site of protozoal infection. These diseases may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
A myelin protein found in the periaxonal membrane of both the central and peripheral nervous systems myelin sheaths. It binds to cells surface receptors found on AXONS and may regulate cellular interactions between MYELIN and AXONS.
A transmembrane protein present in the MYELIN SHEATH of the CENTRAL NERVOUS SYSTEM. It is one of the main autoantigens implicated in the pathogenesis of MULTIPLE SCLEROSIS.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
A species of CARDIOVIRUS which contains three strains: Theiler's murine encephalomyelitis virus, Vilyuisk human encephalomyelitis virus, and Rat encephalomyelitis virus.
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
Formation of NEURONS which involves the differentiation and division of STEM CELLS in which one or both of the daughter cells become neurons.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
Conditions characterized by loss or dysfunction of myelin (see MYELIN SHEATH) in the brain, spinal cord, or optic nerves secondary to autoimmune mediated processes. This may take the form of a humoral or cellular immune response directed toward myelin or OLIGODENDROGLIA associated autoantigens.
Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
Neurons which activate MUSCLE CELLS.
Infections of the nervous system caused by fungi of the genus ASPERGILLUS, most commonly ASPERGILLUS FUMIGATUS. Aspergillus infections may occur in immunocompetent hosts, but are more prevalent in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES. The organism may spread to the nervous system from focal infections in the lung, mastoid region, sinuses, inner ear, bones, eyes, gastrointestinal tract, and heart. Sinus infections may be locally invasive and enter the intracranial compartment, producing MENINGITIS, FUNGAL; cranial neuropathies; and abscesses in the frontal lobes of the brain. (From Joynt, Clinical Neurology, 1998, Ch 27, pp62-3)
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The biochemical and electrophysiological interactions between the NERVOUS SYSTEM and IMMUNE SYSTEM.
Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A circumscribed collection of purulent exudate in the brain, due to bacterial and other infections. The majority are caused by spread of infected material from a focus of suppuration elsewhere in the body, notably the PARANASAL SINUSES, middle ear (see EAR, MIDDLE); HEART (see also ENDOCARDITIS, BACTERIAL), and LUNG. Penetrating CRANIOCEREBRAL TRAUMA and NEUROSURGICAL PROCEDURES may also be associated with this condition. Clinical manifestations include HEADACHE; SEIZURES; focal neurologic deficits; and alterations of consciousness. (Adams et al., Principles of Neurology, 6th ed, pp712-6)
A thin membrane that lines the CEREBRAL VENTRICLES and the central canal of the SPINAL CORD.
The craniosacral division of the autonomic nervous system. The cell bodies of the parasympathetic preganglionic fibers are in brain stem nuclei and in the sacral spinal cord. They synapse in cranial autonomic ganglia or in terminal ganglia near target organs. The parasympathetic nervous system generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system.
The 2nd cranial nerve which conveys visual information from the RETINA to the brain. The nerve carries the axons of the RETINAL GANGLION CELLS which sort at the OPTIC CHIASM and continue via the OPTIC TRACTS to the brain. The largest projection is to the lateral geniculate nuclei; other targets include the SUPERIOR COLLICULI and the SUPRACHIASMATIC NUCLEI. Though known as the second cranial nerve, it is considered part of the CENTRAL NERVOUS SYSTEM.
Disorders caused by cellular or humoral immune responses primarily directed towards nervous system autoantigens. The immune response may be directed towards specific tissue components (e.g., myelin) and may be limited to the central nervous system (e.g., MULTIPLE SCLEROSIS) or the peripheral nervous system (e.g., GUILLAIN-BARRE SYNDROME).
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
In tissue culture, hairlike projections of neurons stimulated by growth factors and other molecules. These projections may go on to form a branched tree of dendrites or a single axon or they may be reabsorbed at a later stage of development. "Neurite" may refer to any filamentous or pointed outgrowth of an embryonal or tissue-culture neural cell.
A species of the CORONAVIRUS genus causing hepatitis in mice. Four strains have been identified as MHV 1, MHV 2, MHV 3, and MHV 4 (also known as MHV-JHM, which is neurotropic and causes disseminated encephalomyelitis with demyelination as well as focal liver necrosis).
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Introduction of therapeutic agents into the spinal region using a needle and syringe.
Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. Neural stem cells are precursors to both NEURONS and NEUROGLIA.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
The observable response an animal makes to any situation.
Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.
A myelin protein that is the major component of the organic solvent extractable lipoprotein complexes of whole brain. It has been the subject of much study because of its unusual physical properties. It remains soluble in chloroform even after essentially all of its bound lipids have been removed. (From Siegel et al., Basic Neurochemistry, 4th ed, p122)
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
A species of fruit fly much used in genetics because of the large size of its chromosomes.
A villous structure of tangled masses of BLOOD VESSELS contained within the third, lateral, and fourth ventricles of the BRAIN. It regulates part of the production and composition of CEREBROSPINAL FLUID.
Established cell cultures that have the potential to propagate indefinitely.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.
A general term for various neoplastic diseases of the lymphoid tissue.
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Infections of the BRAIN; SPINAL CORD; or MENINGES caused by HELMINTHS (parasitic worms).
The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Proteins in the cerebrospinal fluid, normally albumin and globulin present in the ratio of 8 to 1. Increases in protein levels are of diagnostic value in neurological diseases. (Brain and Bannister's Clinical Neurology, 7th ed, p221)
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Clusters of neuronal cell bodies in invertebrates. Invertebrate ganglia may also contain neuronal processes and non-neuronal supporting cells. Many invertebrate ganglia are favorable subjects for research because they have small numbers of functional neuronal types which can be identified from one animal to another.
Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.
The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
The posterior of the three primitive cerebral vesicles of an embryonic brain. It consists of myelencephalon, metencephalon, and isthmus rhombencephali from which develop the major BRAIN STEM components, such as MEDULLA OBLONGATA from the myelencephalon, CEREBELLUM and PONS from the metencephalon, with the expanded cavity forming the FOURTH VENTRICLE.
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The anterior subdivision of the embryonic PROSENCEPHALON or the corresponding part of the adult prosencephalon that includes the cerebrum and associated structures.
Differentiated tissue of the central nervous system composed of NERVE CELLS, fibers, DENDRITES, and specialized supporting cells.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).
Infections of the brain, spinal cord, and meninges caused by parasites.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimeningeal spaces surrounding the spinal cord. Traumatic injuries, vascular diseases, infections, and inflammatory/autoimmune processes may affect the spinal cord.
A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
The physical activity of a human or an animal as a behavioral phenomenon.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Copper chelator that inhibits monoamine oxidase and causes liver and brain damage.
ANIMALS whose GENOME has been altered by GENETIC ENGINEERING, or their offspring.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
A benign tumor of the nervous system that may occur sporadically or in association with VON HIPPEL-LINDAU DISEASE. It accounts for approximately 2% of intracranial tumors, arising most frequently in the cerebellar hemispheres and vermis. Histologically, the tumors are composed of multiple capillary and sinusoidal channels lined with endothelial cells and clusters of lipid-laden pseudoxanthoma cells. Usually solitary, these tumors can be multiple and may also occur in the brain stem, spinal cord, retina, and supratentorial compartment. Cerebellar hemangioblastomas usually present in the third decade with INTRACRANIAL HYPERTENSION, and ataxia. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2071-2)
A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, usually causing an inapparent intestinal infection in mice. A small number of mice may show signs of flaccid paralysis.
Twelve pairs of nerves that carry general afferent, visceral afferent, special afferent, somatic efferent, and autonomic efferent fibers.
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
The anterior of the three primitive cerebral vesicles of the embryonic brain arising from the NEURAL TUBE. It subdivides to form DIENCEPHALON and TELENCEPHALON. (Stedmans Medical Dictionary, 27th ed)
The middle of the three primitive cerebral vesicles of the embryonic brain. Without further subdivision, midbrain develops into a short, constricted portion connecting the PONS and the DIENCEPHALON. Midbrain contains two major parts, the dorsal TECTUM MESENCEPHALI and the ventral TEGMENTUM MESENCEPHALI, housing components of auditory, visual, and other sensorimoter systems.
Infections caused by viruses of the genus CARDIOVIRUS, family PICORNAVIRIDAE.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A rare but highly lethal childhood tumor found almost exclusively in infants. Histopathologically, it resembles RHABDOMYOSARCOMA but the tumor cells are not of myogenic origin. Although it arises primarily in the kidney, it may be found in other parts of the body. The rhabdoid cytomorphology is believed to be the expression of a very primitive malignant cell. (From Holland et al., Cancer Medicine, 3d ed, p2210)
A genus of dextrally coiled freshwater snails that includes some species of importance as intermediate hosts of parasitic flukes.
Inherited conditions characterized by a loss of MYELIN in the central nervous system.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.
The paired caudal parts of the PROSENCEPHALON from which the THALAMUS; HYPOTHALAMUS; EPITHALAMUS; and SUBTHALAMUS are derived.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.
Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).
A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)
Plant-eating orthopterans having hindlegs adapted for jumping. There are two main families: Acrididae and Romaleidae. Some of the more common genera are: Melanoplus, the most common grasshopper; Conocephalus, the eastern meadow grasshopper; and Pterophylla, the true katydid.
The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE.
Morphological and physiological development of EMBRYOS or FETUSES.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Mice bearing mutant genes which are phenotypically expressed in the animals.
The functional hereditary units of INSECTS.
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.
The exposure of the head to roentgen rays or other forms of radioactivity for therapeutic or preventive purposes.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Central peptidergic neurons are hyperactive during collateral sprouting and inhibition of activity suppresses sprouting. (1/6116)

Little is known regarding the effect of chronic changes in neuronal activity on the extent of collateral sprouting by identified CNS neurons. We have investigated the relationship between activity and sprouting in oxytocin (OT) and vasopressin (VP) neurons of the hypothalamic magnocellular neurosecretory system (MNS). Uninjured MNS neurons undergo a robust collateral-sprouting response that restores the axon population of the neural lobe (NL) after a lesion of the contralateral MNS (). Simultaneously, lesioned rats develop chronic urinary hyperosmolality indicative of heightened neurosecretory activity. We therefore tested the hypothesis that sprouting MNS neurons are hyperactive by measuring changes in cell and nuclear diameters, OT and VP mRNA pools, and axonal cytochrome oxidase activity (COX). Each of these measures was significantly elevated during the period of most rapid axonal growth between 1 and 4 weeks after the lesion, confirming that both OT and VP neurons are hyperactive while undergoing collateral sprouting. In a second study the hypothesis that chronic inhibition of neuronal activity would interfere with the sprouting response was tested. Chronic hyponatremia (CH) was induced 3 d before the hypothalamic lesion and sustained for 4 weeks to suppress neurosecretory activity. CH abolished the lesion-induced increases in OT and VP mRNA pools and virtually eliminated measurable COX activity in MNS terminals. Counts of the total number of axon profiles in the NL revealed that CH also prevented axonal sprouting from occurring. These results are consistent with the hypothesis that increased neuronal activity is required for denervation-induced collateral sprouting to occur in the MNS.  (+info)

Selective expression of purinoceptor cP2Y1 suggests a role for nucleotide signalling in development of the chick embryo. (2/6116)

Responses to extracellular nucleotides (e.g., ATP, ADP, etc.) have been demonstrated in a number of embryonic cell types suggesting they may be important signalling molecules during embryonic development. Here the authors describe for the first time the expression of a G-protein-coupled receptor for extracellular ATP, chick P2Y1 (cP2Y1), during embryonic development of the chick. During the first 10 days of embryonic development, cP2Y1 is expressed in a developmentally regulated manner in the limb buds, mesonephros, brain, somites, and facial primordia, suggesting that this receptor may have a role in the development of each of these systems.  (+info)

Actions of a pair of identified cerebral-buccal interneurons (CBI-8/9) in Aplysia that contain the peptide myomodulin. (3/6116)

A combination of biocytin back-fills of the cerebral-buccal connectives and immunocytochemistry of the cerebral ganglion demonstrated that of the 13 bilateral pairs of cerebral-buccal interneurons in the cerebral ganglion, a subpopulation of 3 are immunopositive for the peptide myomodulin. The present paper describes the properties of two of these cells, which we have termed CBI-8 and CBI-9. CBI-8 and CBI-9 were found to be dye coupled and electrically coupled. The cells have virtually identical properties, and consequently we consider them to be "twin" pairs and refer to them as CBI-8/9. CBI-8/9 were identified by electrophysiological criteria and then labeled with dye. Labeled cells were found to be immunopositive for myomodulin, and, using high pressure liquid chromatography, the cells were shown to contain authentic myomodulin. CBI-8/9 were found to receive synaptic input after mechanical stimulation of the tentacles. They also received excitatory input from C-PR, a neuron involved in neck lengthening, and received a slow inhibitory input from CC5, a cell involved in neck shortening, suggesting that CBI-8/9 may be active during forward movements of the head or buccal mass. Firing of CBI-8 or CBI-9 resulted in the activation of a relatively small number of buccal neurons as evidenced by extracellular recordings from buccal nerves. Firing also produced local movements of the buccal mass, in particular a strong contraction of the I7 muscle, which mediates radula opening. CBI-8/9 were found to produce a slow depolarization and rhythmic activity of B48, the motor neuron for the I7 muscle. The data provide continuing evidence that the small population of cerebral buccal interneurons is composed of neurons that are highly diverse in their functional roles. CBI-8/9 may function as a type of premotor neuron, or perhaps as a peptidergic modulatory neuron, the functions of which are dependent on the coactivity of other neurons.  (+info)

C-PR neuron of Aplysia has differential effects on "Feeding" cerebral interneurons, including myomodulin-positive CBI-12. (4/6116)

Head lifting and other aspects of the appetitive central motive state that precedes consummatory feeding movements in Aplysia is promoted by excitation of the C-PR neuron. Food stimuli activate C-PR as well as a small population of cerebral-buccal interneurons (CBIs). We wished to determine if firing of C-PR produced differential effects on the various CBIs or perhaps affected all the CBIs uniformly as might be expected for a neuron involved in producing a broad undifferentiated arousal state. We found that when C-PR was fired, it produced a wide variety of effects on various CBIs. Firing of C-PR evoked excitatory input to a newly identified CBI (CBI-12) the soma of which is located in the M cluster near the previously identified CBI-2. CBI-12 shares certain properties with CBI-2, including a similar morphology and a capacity to drive rhythmic activity of the buccal-ganglion. Unlike CBI-2, CBI-12 exhibits myomodulin immunoreactivity. Furthermore when C-PR is fired, CBI-12 receives a polysynaptic voltage-dependent slow excitation, whereas, CBI-2 receives relatively little input. C-PR also polysynaptically excites other CBIs including CBI-1 and CBI-8/9 but produces inhibition in CBI-3. In addition, firing of C-PR inhibits plateau potentials in CBI-5/6. The data suggest that activity of C-PR may promote the activity of one subset of cerebral-buccal interneurons, perhaps those involved in ingestive behaviors that occur during the head-up posture. C-PR also inhibits some cerebral-buccal interneurons that may be involved in behaviors in which C-PR activity is not required or may even interfere with other feeding behaviors such as rejection or grazing, that occur with the head down.  (+info)

Central autonomic activation by intracisternal TRH analogue excites gastric splanchnic afferent neurons. (5/6116)

Intracisternal (ic) injection of thyrotropin-releasing hormone (TRH) or its stable analogue RX 77368 influences gastric function via stimulation of vagal muscarinic pathways. In rats, the increase in gastric mucosal blood flow evoked by a low ic dose of RX 77368 occurs via release of calcitonin gene-related peptide from capsaicin-sensitive afferent neurons, most probably of spinal origin. In this study, the effect of low ic doses of RX 77368 on afferent impulse activity in splanchnic single fibers was investigated. The cisterna magna of overnight-fasted, urethan-anesthetized Sprague-Dawley rats was acutely cannulated, and fine splanchnic nerve twigs containing at least one fiber responsive to mechanical probing of the stomach were isolated at a site immediately distal to the left suprarenal ganglion. Unit mechanoreceptive fields were encountered in all portions of the stomach, both superficially and in deeper layers. Splanchnic afferent unit impulse activity was recorded continuously during basal conditions and in response to consecutive ic injections of saline and RX 77368 (15-30 min later; 1.5 or 3 ng). Basal discharge rates ranged from 0 to 154 impulses/min (median = 10.2 impulses/min). A majority of splanchnic single units with ongoing activity increased their mean discharge rate by >/=20% after ic injection of RX 77368 at either 1.5 ng (6/10 units; median increase 63%) or 3 ng (19/24 units; median increase 175%). Five units lacking impulse activity in the 5-min before ic RX 77368 (3 ng) were also excited, with the onset of discharge occurring within 1.0-5.0 min postinjection. In units excited by ic RX 77368, peak discharge occurred 15.6 +/- 1.3 min after injection and was followed by a decline to stable activity levels +info)

Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos. (6/6116)

The tumor suppressor RB regulates diverse cellular processes such as G1/S transition, cell differentiation, and cell survival. Indeed, Rb-knockout mice exhibit phenotypes including ectopic mitosis, defective differentiation, and extensive apoptosis in the neurons. Using differential display, a novel gene, Rig-1, was isolated based on its elevated expression in the hindbrain and spinal cord of Rb-knockout embryos. The longest open reading frame of Rig-1 encoded a polypeptide that consists of a putative extracellular segment with five immunoglobulin-like domains and three fibronectin III-like domains, a putative transmembrane domain, and a distinct intracellular segment. The Rig-1 sequence was 40% identical to the recently identified roundabout protein. Consistent with the predicted transmembrane nature of the protein, Rig-1 protein was present in the membranous fraction. Antisera raised against the putative extracellular and intracellular segments of Rig-1 reacted with an approximately 210-kDa protein in mouse embryonic CNS. Rig-1 mRNA was transiently expressed in the embryonic hindbrain and spinal cord. Elevated levels of Rig-1 mRNA and protein were found in Rb-/- embryos. Ectopic expression of a transmembrane form of Rig-1, but not the secreted form, promoted neuronal cell entrance to S phase and repressed the expression of a marker of differentiated neuron, Talpha1 tubulin. Thus Rig-1, a possible distant relative of roundabout, may mediate some of the pleiotropic roles of RB in the developing neurons.  (+info)

Neuronal differentiation and patterning in Xenopus: the role of cdk5 and a novel activator xp35.2. (7/6116)

Cdk5, a member of the cyclin-dependent kinase family, has been shown to play an important role in development of the central nervous system in mammals when partnered by its activator p35. Here we describe the cloning and characterization of a novel activator of cdk5 in Xenopus, Xp35.2. Xp35.2 is expressed during development initially in the earliest differentiating primary neurons in the neural plate and then later in differentiating neural tissue of the brain. This is in contrast to the previously described Xenopus cdk5 activator Xp35.1 which is expressed over the entire expanse of the neural plate in both proliferating and differentiating cells. Expression of both Xp35.1 and Xp35.2 and activation of cdk5 kinase occur when terminal neural differentiation is induced by neurogenin and neuro D overexpression but not when only early stages of neural differentiation are induced by noggin. Moreover, blocking cdk5 kinase activity specifically results in disruption and reduction of the embryonic eye where cdk5 and its Xp35 activators are expressed. Thus, cdk5/p35 complexes function in aspects of neural differentiation and patterning in the early embryo and particularly in formation of the eye.  (+info)

Induction of Sarcophaga central nervous system remodeling by 20-hydroxyecdysone in vitro. (8/6116)

Proliferation and apoptosis of neural cells were found to be induced simultaneously when larval brains of Sarcophaga peregrina were cultured in the presence of 20-hydroxyecdysone (20-HE) for 24 h. The locations of proliferating cells and apoptotic cells in the brain hemispheres were different. The morphology of brains exposed to 20-HE for a short period proceeded to change sequentially when culture was continued for 2 days even in the absence of 20-HE. These changes mainly consisted of enlargement of the brain hemispheres and extension of the interval between two hemispheres, which closely paralleled the morphological changes of brains that occur in the early pupal stage, suggesting that ecdysteroid alone is sufficient to induce the remodeling of the central nervous system of holometabolous insects. Synthesis of a protein with a molecular mass of 66 kDa was shown to be selectively repressed when brains were cultured in the presence of 20-HE.  (+info)

1. Neurodegenerative diseases: These are diseases that cause progressive loss of brain cells, leading to cognitive decline and motor dysfunction. Examples include Alzheimer's disease, Parkinson's disease, and Huntington's disease.
2. Stroke: A stroke occurs when blood flow to the brain is interrupted, leading to cell death and potential long-term disability.
3. Traumatic brain injury: This type of injury occurs when the brain is subjected to a sudden and forceful impact, such as in a car accident or fall.
4. Infections: Bacterial, viral, and fungal infections can all cause CNS diseases, such as meningitis and encephalitis.
5. Autoimmune disorders: These are conditions in which the immune system mistakenly attacks healthy cells in the brain, leading to inflammation and damage. Examples include multiple sclerosis and lupus.
6. Brain tumors: Tumors can occur in any part of the brain and can be benign or malignant.
7. Cerebrovascular diseases: These are conditions that affect the blood vessels in the brain, such as aneurysms and arteriovenous malformations (AVMs).
8. Neurodevelopmental disorders: These are conditions that affect the development of the brain and nervous system, such as autism spectrum disorder and attention deficit hyperactivity disorder (ADHD).

CNS diseases can have a significant impact on quality of life, and some can be fatal. Treatment options vary depending on the specific diagnosis and severity of the disease. Some CNS diseases can be managed with medication, while others may require surgery or other interventions.

Benign CNS neoplasms include:

1. Meningiomas: These are the most common type of benign CNS tumor, arising from the meninges (the membranes covering the brain and spinal cord).
2. Acoustic neuromas: These tumors arise from the nerve cells that connect the inner ear to the brain.
3. Pineal gland tumors: These are rare tumors that occur in the pineal gland, a small gland located in the brain.
4. Craniopharyngiomas: These are rare tumors that arise from the remnants of the embryonic pituitary gland and can cause a variety of symptoms including headaches, vision loss, and hormonal imbalances.

Malignant CNS neoplasms include:

1. Gliomas: These are the most common type of malignant CNS tumor and arise from the supporting cells of the brain called glial cells. Examples of gliomas include astrocytomas, oligodendrogliomas, and medulloblastomas.
2. Lymphomas: These are cancers of the immune system that can occur in the CNS.
3. Melanomas: These are rare tumors that arise from the pigment-producing cells of the skin and can spread to other parts of the body, including the CNS.
4. Metastatic tumors: These are tumors that have spread to the CNS from other parts of the body, such as the breast, lung, or colon.

The diagnosis and treatment of central nervous system neoplasms depend on the type, size, location, and severity of the tumor, as well as the patient's overall health and medical history. Treatment options can include surgery, radiation therapy, chemotherapy, targeted therapy, and immunotherapy.

The prognosis for CNS neoplasms varies depending on the type of tumor and the effectiveness of treatment. In general, gliomas have a poorer prognosis than other types of CNS tumors, with five-year survival rates ranging from 30% to 60%. Lymphomas and melanomas have better prognoses, with five-year survival rates of up to 80%. Metastatic tumors have a more guarded prognosis, with five-year survival rates depending on the primary site of the cancer.

In summary, central nervous system neoplasms are abnormal growths of tissue in the brain and spinal cord that can cause a variety of symptoms and can be benign or malignant. The diagnosis and treatment of these tumors depend on the type, size, location, and severity of the tumor, as well as the patient's overall health and medical history. The prognosis for CNS neoplasms varies depending on the type of tumor and the effectiveness of treatment, but in general, gliomas have a poorer prognosis than other types of CNS tumors.

The most common types of CNS infections include:

1. Meningitis: Inflammation of the protective membranes (meninges) that cover the brain and spinal cord, often caused by bacteria or viruses.
2. Encephalitis: Inflammation of the brain tissue itself, usually caused by a virus.
3. Abscesses: Pockets of pus that form in the brain or spinal cord, typically caused by bacterial infections.
4. Cryptococcal infections: Caused by a fungus called Cryptococcus neoformans, often affecting people with weakened immune systems.
5. Toxoplasmosis: A parasitic infection caused by the Toxoplasma gondii parasite, which can affect the CNS in people with compromised immune systems.

Symptoms of CNS infections can vary depending on the specific type and severity of the infection, but may include fever, headache, confusion, seizures, weakness, and stiff neck. Diagnosis is typically made through a combination of physical examination, laboratory tests, and imaging studies such as CT or MRI scans.

Treatment of CNS infections depends on the underlying cause, but may involve antibiotics, antiviral medications, or antifungal drugs. In severe cases, hospitalization and supportive care such as intravenous fluids, oxygen therapy, and respiratory support may be necessary.

Prevention of CNS infections includes good hygiene practices such as frequent handwashing, avoiding close contact with people who are sick, and getting vaccinated against certain viruses that can cause CNS infections. Early diagnosis and prompt treatment are critical to preventing long-term complications of CNS infections and improving outcomes for patients.



Some common examples of CNSVD include:

1. Herpes simplex virus (HSV) encephalitis: This is an inflammation of the brain caused by the herpes simplex virus. It can cause fever, headache, confusion, and seizures.
2. West Nile virus (WNV) encephalitis: This is an infection of the brain caused by the West Nile virus, which is transmitted through the bite of an infected mosquito. Symptoms can include fever, headache, muscle weakness, and confusion.
3. Japanese encephalitis (JE): This is a viral infection that affects the brain and is transmitted through the bite of an infected mosquito. Symptoms can include fever, headache, seizures, and changes in behavior or cognitive function.
4. Rabies: This is a viral infection that affects the brain and is transmitted through the bite of an infected animal, usually a dog, bat, or raccoon. Symptoms can include fever, headache, agitation, and changes in behavior or cognitive function.
5. Enteroviral encephalitis: This is an infection of the brain caused by enteroviruses, which are common viruses that affect the gastrointestinal tract. Symptoms can include fever, vomiting, diarrhea, and changes in behavior or cognitive function.

The diagnosis of CNSVD typically involves a combination of physical examination, laboratory tests (such as blood tests or lumbar puncture), and imaging studies (such as CT or MRI scans). Treatment options vary depending on the specific disease and may include antiviral medications, supportive care, and rehabilitation.

Prevention of CNSVD includes avoiding exposure to mosquitoes and other vectors that can transmit disease, maintaining good hygiene practices (such as washing hands frequently), and getting vaccinated against diseases such as rabies and measles. In addition, taking steps to prevent head trauma and using protective equipment when engaging in activities that involve risk of head injury can help reduce the risk of CNSVD.

Overall, while central nervous system viral diseases can be serious and potentially life-threatening, early diagnosis and treatment can improve outcomes and prevent long-term complications. It is important to seek medical attention promptly if symptoms persist or worsen over time.

The exact cause of CNS vasculitis is not fully understood, but it is believed to be an autoimmune disorder, meaning that the immune system mistakenly attacks healthy tissues in the CNS. The condition can occur at any age, but it most commonly affects adults between the ages of 40 and 60.

Symptoms of CNS vasculitis can vary depending on the location and severity of the inflammation, but may include:

* Headaches
* Confusion
* Memory loss
* Seizures
* Weakness or numbness in the limbs
* Vision problems
* Speech difficulties

Diagnosis of CNS vasculitis typically involves a combination of physical examination, medical history, and diagnostic tests such as MRI or CT scans, lumbar puncture, and blood tests. Treatment options for CNS vasculitis vary depending on the severity of the condition and may include corticosteroids, immunosuppressive drugs, and plasmapheresis. In severe cases, surgery may be necessary to relieve pressure on the brain or spinal cord.

Overall, CNS vasculitis is a serious condition that can have significant neurological consequences if left untreated. Early diagnosis and aggressive treatment are critical to prevent long-term damage and improve outcomes for patients with this condition.

The most common types of CNS fungal infections include:

1. Meningitis: An inflammation of the membranes that cover the brain and spinal cord, caused by fungi such as Candida, Aspergillus, or Cryptococcus.
2. Encephalitis: An inflammation of the brain tissue itself, caused by fungi such as Histoplasma or Coccidioides.
3. Abscesses: Pocket of pus that form in the brain or spinal cord, caused by bacteria or fungi.
4. Opportunistic infections: Infections that occur in people with compromised immune systems, such as HIV/AIDS patients or those taking immunosuppressive drugs after an organ transplant.

CNS fungal infections can cause a wide range of symptoms, including headache, fever, confusion, seizures, and loss of coordination. They are typically diagnosed through a combination of physical examination, laboratory tests, and imaging studies such as CT or MRI scans.

Treatment of CNS fungal infections usually involves the use of antifungal medications, which can be administered intravenously or orally. The choice of treatment depends on the severity and location of the infection, as well as the patient's overall health status. In some cases, surgery may be necessary to drain abscesses or relieve pressure on the brain.

Prevention of CNS fungal infections is important for individuals at risk, such as those with compromised immune systems or underlying medical conditions. This includes taking antifungal medications prophylactically, avoiding exposure to fungal spores, and practicing good hygiene.

Overall, CNS fungal infections are serious and potentially life-threatening conditions that require prompt diagnosis and treatment. With appropriate management, many patients can recover fully, but delays in diagnosis and treatment can lead to poor outcomes.

Examples of Nervous System Diseases include:

1. Alzheimer's disease: A progressive neurological disorder that affects memory and cognitive function.
2. Parkinson's disease: A degenerative disorder that affects movement, balance and coordination.
3. Multiple sclerosis: An autoimmune disease that affects the protective covering of nerve fibers.
4. Stroke: A condition where blood flow to the brain is interrupted, leading to brain cell death.
5. Brain tumors: Abnormal growth of tissue in the brain.
6. Neuropathy: Damage to peripheral nerves that can cause pain, numbness and weakness in hands and feet.
7. Epilepsy: A disorder characterized by recurrent seizures.
8. Motor neuron disease: Diseases that affect the nerve cells responsible for controlling voluntary muscle movement.
9. Chronic pain syndrome: Persistent pain that lasts more than 3 months.
10. Neurodevelopmental disorders: Conditions such as autism, ADHD and learning disabilities that affect the development of the brain and nervous system.

These diseases can be caused by a variety of factors such as genetics, infections, injuries, toxins and ageing. Treatment options for Nervous System Diseases range from medications, surgery, rehabilitation therapy to lifestyle changes.

CNS bacterial infections can cause a wide range of symptoms, including fever, headache, confusion, seizures, and loss of consciousness. In severe cases, these infections can lead to meningitis, encephalitis, or abscesses in the brain or spinal cord.

The diagnosis of CNS bacterial infections is based on a combination of clinical findings, laboratory tests, and imaging studies. Laboratory tests may include blood cultures, cerebrospinal fluid (CSF) cultures, and polymerase chain reaction (PCR) tests to identify the causative bacteria. Imaging studies, such as computed tomography (CT) or magnetic resonance imaging (MRI), may be used to visualize the extent of the infection.

Treatment of CNS bacterial infections typically involves the use of antibiotics, which can help to clear the infection and prevent further complications. In some cases, surgical intervention may be necessary to drain abscesses or relieve pressure on the brain or spinal cord.

Preventive measures for CNS bacterial infections include vaccination against certain types of bacteria, such as Streptococcus pneumoniae and Haemophilus influenzae, good hygiene practices, and appropriate use of antibiotics. Early diagnosis and treatment are critical to preventing long-term neurological damage or death.

In conclusion, CNS bacterial infections can be serious and potentially life-threatening conditions that require prompt diagnosis and treatment. Understanding the causes, symptoms, diagnosis, treatment, and prevention of these infections is essential for effective management and optimal outcomes for patients affected by them.

The symptoms of TB CNS can vary depending on the location and severity of the infection, but may include:

* Headache
* Fever
* Nausea and vomiting
* Weakness or paralysis of the face, arm, or leg
* Confusion, seizures, or coma
* Vision loss or double vision
* Hearing loss or ringing in the ears
* Meningitis (inflammation of the protective membranes covering the brain and spinal cord)

TB CNS can be difficult to diagnose because the symptoms are often non-specific and can resemble other conditions, such as a stroke or a brain tumor. A diagnosis is typically made through a combination of physical examination, imaging tests (such as CT or MRI scans), and laboratory tests (such as lumbar puncture and culture).

TB CNS is treated with antibiotics, usually for a period of at least 6-12 months. In some cases, surgery may be necessary to remove abscesses or repair damaged tissue. Treatment outcomes are generally good if the diagnosis is made early and the infection is contained within the central nervous system. However, delays in diagnosis and treatment can lead to serious complications, such as permanent neurological damage or death.

Prevention of TB CNS involves identifying and treating cases of active TB infection, as well as taking measures to prevent the spread of the disease. This includes screening for TB in high-risk individuals, such as those with weakened immune systems or living in areas with a high prevalence of TB. Vaccination against TB is also recommended in some cases.

In summary, TB CNS is a rare and potentially life-threatening form of tuberculosis that can cause severe neurological symptoms and complications. Early diagnosis and treatment are critical to preventing serious outcomes and ensuring effective management of the disease.

Some common types of nervous system neoplasms include:

1. Brain tumors: These are abnormal growths that develop in the brain, including gliomas (such as glioblastoma), meningiomas, and acoustic neuromas.
2. Spinal cord tumors: These are abnormal growths that develop in the spinal cord, including astrocytomas, oligodendrogliomas, and metastatic tumors.
3. Nerve sheath tumors: These are abnormal growths that develop in the covering of nerves, such as neurofibromas and schwannomas.
4. Pineal gland tumors: These are abnormal growths that develop in the pineal gland, a small endocrine gland located in the brain.

Symptoms of nervous system neoplasms can vary depending on their location and size, but may include headaches, seizures, weakness or numbness in the arms or legs, and changes in vision, speech, or balance. Diagnosis is typically made through a combination of imaging studies (such as MRI or CT scans) and tissue biopsy. Treatment options vary depending on the type and location of the tumor, but may include surgery, radiation therapy, and chemotherapy.

In summary, nervous system neoplasms are abnormal growths that can develop in the brain, spinal cord, and nerves, and can have a significant impact on the body. Diagnosis and treatment require a comprehensive approach, involving a team of medical professionals with expertise in neurology, neurosurgery, radiation oncology, and other related specialties.

The most common demyelinating diseases include:

1. Multiple sclerosis (MS): An autoimmune disease that affects the CNS, including the brain, spinal cord, and optic nerves. MS causes inflammation and damage to the myelin sheath, leading to a range of symptoms such as muscle weakness, vision problems, and cognitive difficulties.
2. Acute demyelination: A sudden, severe loss of myelin that can be caused by infections, autoimmune disorders, or other factors. This condition can result in temporary or permanent nerve damage.
3. Chronic inflammatory demyelination (CIDP): A rare autoimmune disorder that causes progressive damage to the myelin sheath over time. CIDP can affect the CNS and the peripheral nervous system (PNS).
4. Moore's disease: A rare genetic disorder that results in progressive demyelination of the CNS, leading to a range of neurological symptoms including muscle weakness, seizures, and cognitive difficulties.
5. Leukodystrophies: A group of genetic disorders that affect the development or function of myelin-producing cells in the CNS. These conditions can cause progressive loss of myelin and result in a range of neurological symptoms.

Demyelinating diseases can be challenging to diagnose, as the symptoms can be similar to other conditions and the disease progression can be unpredictable. Treatment options vary depending on the specific condition and its severity, and may include medications to reduce inflammation and modulate the immune system, as well as rehabilitation therapies to help manage symptoms and improve quality of life.

The disease is typically induced in laboratory animals such as mice or rats by immunizing them with myelin proteins, such as myelin basic protein (MBP) or proteolipid protein (PLP), emulsified in adjuvants. The resulting immune response leads to the production of autoantibodies and activated T cells that cross the blood-brain barrier and attack the CNS.

EAE is used as a model for MS because it shares many similarities with the human disease, including:

1. Demyelination: EAE induces demyelination of nerve fibers in the CNS, which is also a hallmark of MS.
2. Autoimmune response: The immune response in EAE is triggered by autoantigens, similar to MS.
3. Chronic course: EAE is a chronic disease with recurrent relapses, similar to MS.
4. Lesion distribution: EAE lesions are distributed throughout the CNS, including the cerebral cortex, cerebellum, brainstem, and spinal cord, which is also true for MS.

EAE has been used extensively in the study of MS to investigate the immunopathogenesis of the disease, to develop new diagnostic markers and treatments, and to test the efficacy of potential therapeutic agents.

Some common types of brain diseases include:

1. Neurodegenerative diseases: These are progressive conditions that damage or kill brain cells over time, leading to memory loss, cognitive decline, and movement disorders. Examples include Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS).
2. Stroke: This occurs when blood flow to the brain is interrupted, leading to cell death and potential long-term disability.
3. Traumatic brain injury (TBI): This refers to any type of head injury that causes damage to the brain, such as concussions, contusions, or penetrating wounds.
4. Infections: Viral, bacterial, and fungal infections can all affect the brain, leading to a range of symptoms including fever, seizures, and meningitis.
5. Tumors: Brain tumors can be benign or malignant and can cause a variety of symptoms depending on their location and size.
6. Cerebrovascular diseases: These conditions affect the blood vessels of the brain, leading to conditions such as aneurysms, arteriovenous malformations (AVMs), and Moyamoya disease.
7. Neurodevelopmental disorders: These are conditions that affect the development of the brain and nervous system, such as autism spectrum disorder, ADHD, and intellectual disability.
8. Sleep disorders: Conditions such as insomnia, narcolepsy, and sleep apnea can all have a significant impact on brain function.
9. Psychiatric disorders: Mental health conditions such as depression, anxiety, and schizophrenia can affect the brain and its functioning.
10. Neurodegenerative with brain iron accumulation: Conditions such as Parkinson's disease, Alzheimer's disease, and Huntington's disease are characterized by the accumulation of abnormal proteins and other substances in the brain, leading to progressive loss of brain function over time.

It is important to note that this is not an exhaustive list and there may be other conditions or factors that can affect the brain and its functioning. Additionally, many of these conditions can have a significant impact on a person's quality of life, and it is important to seek medical attention if symptoms persist or worsen over time.

The symptoms of MS can vary widely depending on the location and severity of the damage to the CNS. Common symptoms include:

* Weakness, numbness, or tingling in the limbs
* Fatigue
* Vision problems, such as blurred vision, double vision, or loss of vision
* Difficulty with balance and coordination
* Tremors or spasticity
* Memory and concentration problems
* Mood changes, such as depression or mood swings
* Bladder and bowel problems

There is no cure for MS, but various treatments can help manage the symptoms and slow the progression of the disease. These treatments include:

* Disease-modifying therapies (DMTs) - These medications are designed to reduce the frequency and severity of relapses, and they can also slow the progression of disability. Examples of DMTs include interferons, glatiramer acetate, natalizumab, fingolimod, dimethyl fumarate, teriflunomide, and alemtuzumab.
* Steroids - Corticosteroids can help reduce inflammation during relapses, but they are not a long-term solution.
* Pain management medications - Pain relievers, such as acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs), can help manage pain caused by MS.
* Muscle relaxants - These medications can help reduce spasticity and tremors.
* Physical therapy - Physical therapy can help improve mobility, balance, and strength.
* Occupational therapy - Occupational therapy can help with daily activities and assistive devices.
* Speech therapy - Speech therapy can help improve communication and swallowing difficulties.
* Psychological counseling - Counseling can help manage the emotional and psychological aspects of MS.

It's important to note that each person with MS is unique, and the best treatment plan will depend on the individual's specific symptoms, needs, and preferences. It's essential to work closely with a healthcare provider to find the most effective treatment plan.

Brain neoplasms can arise from various types of cells in the brain, including glial cells (such as astrocytes and oligodendrocytes), neurons, and vascular tissues. The symptoms of brain neoplasms vary depending on their size, location, and type, but may include headaches, seizures, weakness or numbness in the limbs, and changes in personality or cognitive function.

There are several different types of brain neoplasms, including:

1. Meningiomas: These are benign tumors that arise from the meninges, the thin layers of tissue that cover the brain and spinal cord.
2. Gliomas: These are malignant tumors that arise from glial cells in the brain. The most common type of glioma is a glioblastoma, which is aggressive and hard to treat.
3. Pineal parenchymal tumors: These are rare tumors that arise in the pineal gland, a small endocrine gland in the brain.
4. Craniopharyngiomas: These are benign tumors that arise from the epithelial cells of the pituitary gland and the hypothalamus.
5. Medulloblastomas: These are malignant tumors that arise in the cerebellum, specifically in the medulla oblongata. They are most common in children.
6. Acoustic neurinomas: These are benign tumors that arise on the nerve that connects the inner ear to the brain.
7. Oligodendrogliomas: These are malignant tumors that arise from oligodendrocytes, the cells that produce the fatty substance called myelin that insulates nerve fibers.
8. Lymphomas: These are cancers of the immune system that can arise in the brain and spinal cord. The most common type of lymphoma in the CNS is primary central nervous system (CNS) lymphoma, which is usually a type of B-cell non-Hodgkin lymphoma.
9. Metastatic tumors: These are tumors that have spread to the brain from another part of the body. The most common types of metastatic tumors in the CNS are breast cancer, lung cancer, and melanoma.

These are just a few examples of the many types of brain and spinal cord tumors that can occur. Each type of tumor has its own unique characteristics, such as its location, size, growth rate, and biological behavior. These factors can help doctors determine the best course of treatment for each patient.

The symptoms of encephalomyelitis can vary depending on the cause and severity of the condition. Common symptoms include fever, headache, neck stiffness, muscle weakness, confusion, seizures, and loss of sensation or paralysis in parts of the body. In severe cases, encephalomyelitis can lead to life-threatening complications such as brain damage, stroke, and respiratory failure.

The diagnosis of encephalomyelitis is based on a combination of clinical features, laboratory tests, and imaging studies. Laboratory tests may include blood tests to detect the presence of inflammatory markers or antibodies against specific infectious agents. Imaging studies such as CT or MRI scans can help to identify inflammation in the brain and spinal cord.

Treatment of encephalomyelitis depends on the underlying cause of the condition. In some cases, antiviral medications may be used to treat infections such as herpes simplex or West Nile virus. In other cases, corticosteroids may be prescribed to reduce inflammation and prevent further damage. Supportive care such as intravenous fluids, oxygen therapy, and physical therapy may also be necessary to manage symptoms and promote recovery.

In conclusion, encephalomyelitis is a serious condition that can cause significant morbidity and mortality. Early diagnosis and prompt treatment are essential to prevent complications and improve outcomes for patients with this condition.

Encephalitis can cause a range of symptoms, including fever, headache, confusion, seizures, and loss of consciousness. In severe cases, encephalitis can lead to brain damage, coma, and even death.

The diagnosis of encephalitis is based on a combination of clinical signs, laboratory tests, and imaging studies. Laboratory tests may include blood tests to detect the presence of antibodies or antigens specific to the causative agent, as well as cerebrospinal fluid (CSF) analysis to look for inflammatory markers and/or bacteria or viruses in the CSF. Imaging studies, such as CT or MRI scans, may be used to visualize the brain and identify any areas of damage or inflammation.

Treatment of encephalitis typically involves supportive care, such as intravenous fluids, oxygen therapy, and medication to manage fever and pain. Antiviral or antibacterial drugs may be used to target the specific causative agent, if identified. In severe cases, hospitalization in an intensive care unit (ICU) may be necessary to monitor and manage the patient's condition.

Prevention of encephalitis includes vaccination against certain viruses that can cause the condition, such as herpes simplex virus and Japanese encephalitis virus. Additionally, avoiding exposure to mosquitoes and other insects that can transmit viruses or bacteria that cause encephalitis, as well as practicing good hygiene and sanitation, can help reduce the risk of infection.

Overall, encephalitis is a serious and potentially life-threatening condition that requires prompt medical attention for proper diagnosis and treatment. With appropriate care, many patients with encephalitis can recover fully or partially, but some may experience long-term neurological complications or disability.

A type of encephalitis caused by a virus that inflames the brain and spinal cord, leading to fever, headache, confusion, seizures, and in severe cases, coma or death. Viral encephalitis is usually transmitted through the bite of an infected mosquito or tick, but can also be spread through contact with infected blood or organs. Diagnosis is made through a combination of physical examination, laboratory tests, and imaging studies. Treatment typically involves supportive care, such as intravenous fluids, oxygen therapy, and medication to manage fever and seizures, as well as antiviral medications in severe cases.

Synonyms: viral encephalitis

Antonyms: bacterial encephalitis

Similar term: meningitis

The symptoms of meningoencephalitis can vary depending on the cause, but common signs include fever, headache, stiff neck, confusion, seizures, and loss of consciousness. The disease can progress rapidly and can be fatal if not treated promptly.

Diagnosis is typically made through a combination of physical examination, laboratory tests (such as blood cultures and PCR), and imaging studies (such as CT or MRI scans). Treatment options depend on the underlying cause, but may include antibiotics, antiviral medications, and supportive care to manage symptoms and prevent complications.

Prognosis for meningoencephalitis depends on the severity of the disease and the promptness and effectiveness of treatment. In general, the prognosis is better for patients who receive prompt medical attention and have a mild form of the disease. However, the disease can be severe and potentially life-threatening, especially in young children, older adults, and those with weakened immune systems.

Trauma to the nervous system can have a profound impact on an individual's quality of life, and can lead to a range of symptoms including:

* Headaches
* Dizziness and vertigo
* Memory loss and difficulty concentrating
* Mood changes such as anxiety, depression, or irritability
* Sleep disturbances
* Changes in sensation, such as numbness or tingling
* Weakness or paralysis of certain muscle groups

Trauma to the nervous system can also have long-lasting effects, and may lead to chronic conditions such as post-traumatic stress disorder (PTSD), chronic pain, and fibromyalgia.

Treatment for trauma to the nervous system will depend on the specific nature of the injury and the severity of the symptoms. Some common treatments include:

* Medication to manage symptoms such as pain, anxiety, or depression
* Physical therapy to help regain strength and mobility
* Occupational therapy to help with daily activities and improve function
* Cognitive-behavioral therapy (CBT) to address any emotional or psychological issues
* Alternative therapies such as acupuncture, massage, or meditation to help manage symptoms and promote relaxation.

It's important to seek medical attention if you experience any symptoms of trauma to the nervous system, as prompt treatment can help reduce the risk of long-term complications and improve outcomes.

1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.

2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.

3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.

4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.

5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.

6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.

7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.

8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.

9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.

10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.

Symptoms of CNS lupus vasculitis can include headaches, seizures, confusion, weakness or paralysis, vision problems, and changes in personality or behavior. The condition can be difficult to diagnose, as it may mimic other conditions such as stroke, infection, or tumors.

Treatment of CNS lupus vasculitis typically involves high doses of corticosteroids to reduce inflammation and prevent further damage. In severe cases, intravenous immunoglobulin (IVIG) or plasmapheresis may be used to remove harmful antibodies from the blood. Anticoagulation therapy may also be prescribed to prevent blood clots.

While CNS lupus vasculitis can be a life-threatening condition, early diagnosis and aggressive treatment can improve outcomes. However, long-term follow-up is essential to monitor for recurrences of the disease and manage any ongoing neurological symptoms.

Benign spinal cord neoplasms are typically slow-growing and may not cause any symptoms in the early stages. However, as they grow, they can compress or damage the surrounding healthy tissue, leading to a range of symptoms such as pain, numbness, weakness, or paralysis.

Malignant spinal cord neoplasms are more aggressive and can grow rapidly, invading surrounding tissues and spreading to other parts of the body. They can cause similar symptoms to benign tumors, as well as other symptoms such as fever, nausea, and weight loss.

The diagnosis of spinal cord neoplasms is based on a combination of clinical findings, imaging studies (such as MRI or CT scans), and biopsy. Treatment options vary depending on the type and location of the tumor, but may include surgery, radiation therapy, and chemotherapy.

The prognosis for spinal cord neoplasms depends on the type and location of the tumor, as well as the patient's overall health. In general, benign tumors have a better prognosis than malignant tumors, and early diagnosis and treatment can improve outcomes. However, even with successful treatment, some patients may experience long-term neurological deficits or other complications.

Viral meningitis is a type of meningitis that is caused by a viral infection. It is a common and often mild form of meningitis that can affect people of all ages. The symptoms of viral meningitis are similar to those of bacterial meningitis, but they tend to be less severe and resolve more quickly.

Causes and Risk Factors:

Viral meningitis is caused by a variety of viruses, including enteroviruses, herpesviruses, and West Nile virus. The infection is usually spread through contact with an infected person's saliva, mucus, or other bodily fluids. People who are at higher risk for developing viral meningitis include young children, older adults, and those with weakened immune systems.

Symptoms:

The symptoms of viral meningitis can include fever, headache, neck stiffness, confusion, nausea, vomiting, and sensitivity to light. In severe cases, the infection can cause seizures, brain damage, and even death.

Diagnosis:

Viral meningitis is diagnosed based on a combination of symptoms, physical examination findings, and laboratory tests. A healthcare provider may perform a lumbar puncture (spinal tap) to collect cerebrospinal fluid (CSF) for testing. The CSF can be tested for the presence of viruses or other signs of infection.

Treatment and Prognosis:

There is no specific treatment for viral meningitis, but symptoms can be managed with rest, hydration, and over-the-counter pain relievers. Antiviral medications may be prescribed in some cases. Most people with viral meningitis recover fully within a week or two, but some may experience lingering fatigue or other symptoms for several weeks. In rare cases, the infection can lead to long-term complications such as hearing loss or learning disabilities.

Prevention:

There is no vaccine to prevent viral meningitis, but good hygiene practices can help reduce the risk of infection. These include:

1. Washing hands frequently, especially after contact with someone who is sick.
2. Avoiding close contact with people who are sick.
3. Covering the mouth and nose when coughing or sneezing.
4. Not sharing drinks or utensils with others.
5. Keeping surfaces clean and disinfected, especially in areas where food is prepared or eaten.

It's important to note that bacterial meningitis can be prevented with vaccines, and it's crucial to seek medical attention immediately if symptoms of meningitis are present.

Types of Central Nervous System Protozoal Infections:

1. Toxoplasmosis: This is an infection caused by the protozoan parasite Toxoplasma gondii, which can affect the CNS and cause a range of symptoms including headache, fever, and neurological problems.
2. Cryptococcosis: This is an infection caused by the fungus-like protozoan Cryptococcus neoformans, which can infect the CNS and cause meningitis or brain abscesses.
3. Microsporidiosis: This is an infection caused by the protozoan parasite Microsporidia, which can affect the CNS and cause a range of symptoms including headache, fever, and neurological problems.
4. Babesiosis: This is an infection caused by the protozoan parasite Babesia, which can infect the CNS and cause a range of symptoms including headache, fever, and neurological problems.
5. Leishmaniasis: This is an infection caused by the protozoan parasite Leishmania, which can affect the CNS and cause a range of symptoms including headache, fever, and neurological problems.

Causes and Risk Factors:

1. Poor sanitation and hygiene
2. Contact with infected animals or contaminated food and water
3. Weakened immune system due to HIV/AIDS or cancer treatment
4. Traveling to areas where the infection is common
5. Pregnancy

Symptoms:

1. Headache
2. Fever
3. Confusion
4. Seizures
5. Weakness or paralysis
6. Vision problems
7. Speech difficulties
8. Swelling of the brain

Diagnosis:

1. Physical examination and medical history
2. Laboratory tests such as blood smears, PCR, and ELISA
3. Imaging studies such as CT or MRI scans
4. Lumbar puncture to collect cerebrospinal fluid (CSF) for testing

Treatment:

1. Antiparasitic drugs such as pentavalent antimonials, chloroquine, and quinine
2. Supportive care such as antibiotics for secondary infections, and management of fever and pain
3. In severe cases, hospitalization may be necessary to monitor and treat complications

Prevention:

1. Avoiding contact with infected animals or contaminated food and water
2. Proper sanitation and hygiene practices
3. Use of insecticides and protective clothing when traveling to areas where the infection is common
4. Eliminating standing water around homes and communities to reduce mosquito breeding sites
5. Vaccination against the disease, which is not currently available but being developed.

The symptoms of meningeal neoplasms vary depending on the location, size, and type of tumor. Common symptoms include headaches, seizures, weakness or numbness in the arms or legs, and changes in vision, memory, or behavior. As the tumor grows, it can compress or displaces the brain tissue, leading to increased intracranial pressure and potentially life-threatening complications.

There are several different types of meningeal neoplasms, including:

1. Meningioma: This is the most common type of meningeal neoplasm, accounting for about 75% of all cases. Meningiomas are usually benign and grow slowly, but they can sometimes be malignant.
2. Metastatic tumors: These are tumors that have spread to the meninges from another part of the body, such as the lung or breast.
3. Lymphoma: This is a type of cancer that affects the immune system and can spread to the meninges.
4. Melanotic neuroectodermal tumors (MNTs): These are rare, malignant tumors that usually occur in children and young adults.
5. Hemangiopericytic hyperplasia: This is a rare, benign condition characterized by an overgrowth of blood vessels in the meninges.

The diagnosis of meningeal neoplasms is based on a combination of clinical symptoms, physical examination findings, and imaging studies such as CT or MRI scans. A biopsy may be performed to confirm the diagnosis and determine the type of tumor.

Treatment options for meningeal neoplasms depend on the type, size, and location of the tumor, as well as the patient's overall health. Surgery is often the first line of treatment, and may involve removing as much of the tumor as possible or using a laser to ablate (destroy) the tumor cells. Radiation therapy and chemotherapy may also be used in combination with surgery to treat malignant meningeal neoplasms.

Prognosis for meningeal neoplasms varies depending on the type of tumor and the patient's overall health. In general, early diagnosis and treatment improve the prognosis, while later-stage tumors may have a poorer outcome.

There are many different types of nerve degeneration that can occur in various parts of the body, including:

1. Alzheimer's disease: A progressive neurological disorder that affects memory and cognitive function, leading to degeneration of brain cells.
2. Parkinson's disease: A neurodegenerative disorder that affects movement and balance, caused by the loss of dopamine-producing neurons in the brain.
3. Amyotrophic lateral sclerosis (ALS): A progressive neurological disease that affects nerve cells in the brain and spinal cord, leading to muscle weakness, paralysis, and eventually death.
4. Multiple sclerosis: An autoimmune disease that affects the central nervous system, causing inflammation and damage to nerve fibers.
5. Diabetic neuropathy: A complication of diabetes that can cause damage to nerves in the hands and feet, leading to pain, numbness, and weakness.
6. Guillain-Barré syndrome: An autoimmune disorder that can cause inflammation and damage to nerve fibers, leading to muscle weakness and paralysis.
7. Chronic inflammatory demyelinating polyneuropathy (CIDP): An autoimmune disorder that can cause inflammation and damage to nerve fibers, leading to muscle weakness and numbness.

The causes of nerve degeneration are not always known or fully understood, but some possible causes include:

1. Genetics: Some types of nerve degeneration may be inherited from one's parents.
2. Aging: As we age, our nerve cells can become damaged or degenerate, leading to a decline in cognitive and physical function.
3. Injury or trauma: Physical injury or trauma to the nervous system can cause nerve damage and degeneration.
4. Infections: Certain infections, such as viral or bacterial infections, can cause nerve damage and degeneration.
5. Autoimmune disorders: Conditions such as Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy (CIDP) are caused by the immune system attacking and damaging nerve cells.
6. Toxins: Exposure to certain toxins, such as heavy metals or pesticides, can damage and degenerate nerve cells.
7. Poor nutrition: A diet that is deficient in essential nutrients, such as vitamin B12 or other B vitamins, can lead to nerve damage and degeneration.
8. Alcoholism: Long-term alcohol abuse can cause nerve damage and degeneration due to the toxic effects of alcohol on nerve cells.
9. Drug use: Certain drugs, such as chemotherapy drugs and antiviral medications, can damage and degenerate nerve cells.
10. Aging: As we age, our nerve cells can deteriorate and become less functional, leading to a range of cognitive and motor symptoms.

It's important to note that in some cases, nerve damage and degeneration may be irreversible, but there are often strategies that can help manage symptoms and improve quality of life. If you suspect you have nerve damage or degeneration, it's important to seek medical attention as soon as possible to receive an accurate diagnosis and appropriate treatment.

Peripheral Nervous System Diseases can result from a variety of causes, including:

1. Trauma or injury
2. Infections such as Lyme disease or HIV
3. Autoimmune disorders such as Guillain-Barré syndrome
4. Genetic mutations
5. Tumors or cysts
6. Toxins or poisoning
7. Vitamin deficiencies
8. Chronic diseases such as diabetes or alcoholism

Some common Peripheral Nervous System Diseases include:

1. Neuropathy - damage to the nerves that can cause pain, numbness, and weakness in the affected areas.
2. Multiple Sclerosis (MS) - an autoimmune disease that affects the CNS and PNS, causing a range of symptoms including numbness, weakness, and vision problems.
3. Peripheral Neuropathy - damage to the nerves that can cause pain, numbness, and weakness in the affected areas.
4. Guillain-Barré syndrome - an autoimmune disorder that causes muscle weakness and paralysis.
5. Charcot-Marie-Tooth disease - a group of inherited disorders that affect the nerves in the feet and legs, leading to muscle weakness and wasting.
6. Friedreich's ataxia - an inherited disorder that affects the nerves in the spine and limbs, leading to coordination problems and muscle weakness.
7. Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - an autoimmune disorder that causes inflammation of the nerves, leading to pain, numbness, and weakness in the affected areas.
8. Amyotrophic Lateral Sclerosis (ALS) - a progressive neurological disease that affects the nerve cells responsible for controlling voluntary muscle movement, leading to muscle weakness, atrophy, and paralysis.
9. Spinal Muscular Atrophy - an inherited disorder that affects the nerve cells responsible for controlling voluntary muscle movement, leading to muscle weakness and wasting.
10. Muscular Dystrophy - a group of inherited disorders that affect the nerve cells responsible for controlling voluntary muscle movement, leading to muscle weakness and wasting.

It's important to note that this is not an exhaustive list and there may be other causes of muscle weakness. If you are experiencing persistent or severe muscle weakness, it is important to see a healthcare professional for proper evaluation and diagnosis.

The exact cause of ADC is not fully understood, but it is believed to be related to the progression of HIV infection in the brain. As HIV replicates in the brain, it can damage brain cells and disrupt normal brain function.

ADC typically affects individuals who have advanced HIV infection and a low CD4 cell count (a measure of immune system health). It is more common in women than men and tends to occur at an older age.

There are several symptoms of ADC, including:

1. Cognitive impairment: difficulty with memory, concentration, and decision-making.
2. Changes in personality and behavior: depression, anxiety, and agitation.
3. Difficulty with speech and language: slurred speech, trouble finding the right words.
4. Coordination and balance problems: unsteadiness, tremors, and difficulty with movement.
5. Seizures: ADC can cause seizures, which can be a sign of a more severe form of the disorder.

There is no cure for ADC, but treatment can help manage its symptoms and slow its progression. Treatment typically involves a combination of antiretroviral therapy (ART) to suppress HIV replication, and medications to manage cognitive and behavioral symptoms. In addition, supportive care, such as physical therapy and occupational therapy, can help improve quality of life.

In conclusion, AIDS Dementia Complex (ADC) is a serious neurological disorder that affects individuals with advanced HIV infection. It is characterized by cognitive impairment, changes in personality and behavior, and difficulty with speech and movement. While there is no cure for ADC, treatment can help manage its symptoms and slow its progression.

There are many different types of ANS diseases, including:

1. Dysautonomia: a general term that refers to dysfunction of the autonomic nervous system.
2. Postural orthostatic tachycardia syndrome (POTS): a condition characterized by rapid heart rate and other symptoms that occur upon standing.
3. Neurocardiogenic syncope: a form of fainting caused by a sudden drop in blood pressure.
4. Multiple system atrophy (MSA): a progressive neurodegenerative disorder that affects the autonomic nervous system and other parts of the brain.
5. Parkinson's disease: a neurodegenerative disorder that can cause autonomic dysfunction, including constipation, urinary incontinence, and erectile dysfunction.
6. Dopamine deficiency: a condition characterized by low levels of the neurotransmitter dopamine, which can affect the ANS and other body systems.
7. Autonomic nervous system disorders associated with autoimmune diseases, such as Guillain-Barré syndrome and lupus.
8. Trauma: physical or emotional trauma can sometimes cause dysfunction of the autonomic nervous system.
9. Infections: certain infections, such as Lyme disease, can affect the autonomic nervous system.
10. Genetic mutations: some genetic mutations can affect the functioning of the autonomic nervous system.

Treatment for ANS diseases depends on the specific condition and its underlying cause. In some cases, medication may be prescribed to regulate heart rate, blood pressure, or other bodily functions. Lifestyle changes, such as regular exercise and stress management techniques, can also be helpful in managing symptoms. In severe cases, surgery may be necessary to correct anatomical abnormalities or repair damaged nerves.

The most common demyelinating autoimmune diseases affecting the CNS are:

1. Multiple sclerosis (MS): A chronic and often disabling disease that affects the brain, spinal cord, and optic nerves. MS is caused by an abnormal response of the immune system, leading to inflammation and damage to the myelin sheath.
2. Neuromyelitis optica (NMO): A rare autoimmune disorder that affects the optic nerves and spinal cord, causing inflammation and demyelination. NMO is often associated with a specific type of antibody in the blood.
3. Acute disseminated encephalomyelitis (ADEM): A rare autoimmune disease that affects the brain and spinal cord, causing widespread inflammation and demyelination. ADEM is often triggered by a viral infection.
4. Chronic inflammatory demyelinating polyneuropathy (CIDP): A rare autoimmune disorder that affects the peripheral nerves, causing weakness, numbness, and pain. CIDP is characterized by inflammation and demyelination of the nerve fibers.

The symptoms of demyelinating autoimmune diseases affecting the CNS can vary depending on the specific disease and the severity of the condition. Common symptoms include:

* Weakness, numbness, or tingling sensations in the limbs
* Vision problems, such as blurred vision or loss of vision
* Difficulty with coordination and balance
* Fatigue, fever, and general malaise
* Cognitive impairment and memory loss

The diagnosis of demyelinating autoimmune diseases affecting the CNS is based on a combination of clinical evaluation, laboratory tests, and imaging studies. Laboratory tests may include:

1. Blood tests to rule out other conditions and measure the levels of specific antibodies and immune cells.
2. Cerebrospinal fluid (CSF) analysis to detect inflammatory markers and specific antibodies.
3. Imaging studies, such as magnetic resonance imaging (MRI) or computed tomography (CT) scans, to visualize the lesions and assess the extent of the damage.
4. Evoked potentials testing to evaluate the function of the nerves.

Treatment for demyelinating autoimmune diseases affecting the CNS depends on the specific disease and the severity of the condition. Common treatments include:

1. Corticosteroids to reduce inflammation and modulate the immune response.
2. Immunoglobulins to block the activity of harmful antibodies.
3. Plasmapheresis to remove harmful antibodies from the blood.
4. Disease-modifying therapies, such as interferons or glatiramer acetate, to reduce the frequency and severity of relapses.
5. Physical therapy and rehabilitation to help restore lost function and improve quality of life.

In conclusion, demyelinating autoimmune diseases affecting the CNS can be challenging to diagnose and treat, but with a comprehensive approach that includes clinical evaluation, laboratory tests, and imaging studies, it is possible to identify the underlying cause and develop an effective treatment plan.

Symptoms of meningitis may include fever, headache, stiff neck, confusion, nausea and vomiting, and sensitivity to light. In severe cases, it can lead to seizures, brain damage, and even death.

There are several types of meningitis, including:

1. Viral meningitis: This is the most common form of the infection and is usually caused by enteroviruses or herpesviruses. It is typically less severe than bacterial meningitis and resolves on its own with supportive care.
2. Bacterial meningitis: This is a more serious form of the infection and can be caused by a variety of bacteria, such as Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. It requires prompt antibiotic treatment to prevent long-term complications and death.
3. Fungal meningitis: This type of meningitis is more common in people with weakened immune systems and is caused by fungi that are commonly found in the environment. It can be treated with antifungal medications.
4. Parasitic meningitis: This type of meningitis is rare and is caused by parasites that are typically found in tropical regions. It can be treated with antiparasitic medications.

Diagnosis of meningitis is based on a combination of clinical findings, laboratory tests, and imaging studies. Laboratory tests may include blood cultures, polymerase chain reaction (PCR) testing, and cerebrospinal fluid (CSF) analysis. Imaging studies, such as CT or MRI scans, may be used to rule out other conditions and to evaluate the extent of brain damage.

Treatment of meningitis depends on the cause of the infection and may include antibiotics, antiviral medications, antifungal medications, or supportive care to manage symptoms and prevent complications. Supportive care may include intravenous fluids, oxygen therapy, and pain management. In severe cases, meningitis may require hospitalization in an intensive care unit (ICU) and may result in long-term consequences such as hearing loss, learning disabilities, or cognitive impairment.

Prevention of meningitis includes vaccination against the bacteria or viruses that can cause the infection, good hygiene practices, and avoiding close contact with people who are sick. Vaccines are available for certain types of meningitis, such as the meningococcal conjugate vaccine (MenACWY) and the pneumococcal conjugate vaccine (PCV). Good hygiene practices include washing hands frequently, covering the mouth and nose when coughing or sneezing, and avoiding sharing food, drinks, or personal items.

In conclusion, meningitis is a serious and potentially life-threatening infection that can affect people of all ages. Early diagnosis and treatment are crucial to prevent long-term consequences and improve outcomes. Prevention includes vaccination, good hygiene practices, and avoiding close contact with people who are sick.



The symptoms of neuroaspergillosis can vary depending on the location and severity of the infection, but may include:

* Headache
* Fever
* Confusion
* Seizures
* Weakness or paralysis
* Vision problems
* Hearing loss

In severe cases, neuroaspergillosis can lead to brain abscesses, stroke, or death.

The diagnosis of neuroaspergillosis is based on a combination of clinical findings, laboratory tests, and imaging studies such as CT or MRI scans. Laboratory tests may include blood cultures, cerebrospinal fluid (CSF) analysis, and PCR testing for Aspergillus DNA.

Treatment of neuroaspergillosis typically involves a combination of antifungal medications and supportive care to manage symptoms and prevent complications. In some cases, surgical intervention may be necessary to drain abscesses or relieve pressure on the brain.

Prevention of neuroaspergillosis primarily involves managing underlying conditions that weaken the immune system, such as HIV/AIDS or cancer, and avoiding exposure to Aspergillus fungi. In high-risk individuals, prophylactic antifungal medications may be used to prevent infection.

Some common examples of neurodegenerative diseases include:

1. Alzheimer's disease: A progressive loss of cognitive function, memory, and thinking skills that is the most common form of dementia.
2. Parkinson's disease: A disorder that affects movement, balance, and coordination, causing tremors, rigidity, and difficulty with walking.
3. Huntington's disease: An inherited condition that causes progressive loss of cognitive, motor, and psychiatric functions.
4. Amyotrophic lateral sclerosis (ALS): A disease that affects the nerve cells responsible for controlling voluntary muscle movement, leading to muscle weakness, paralysis, and eventually death.
5. Prion diseases: A group of rare and fatal disorders caused by misfolded proteins in the brain, leading to neurodegeneration and death.
6. Creutzfeldt-Jakob disease: A rare, degenerative, and fatal brain disorder caused by an abnormal form of a protein called a prion.
7. Frontotemporal dementia: A group of diseases that affect the front and temporal lobes of the brain, leading to changes in personality, behavior, and language.

Neurodegenerative diseases can be caused by a variety of factors, including genetics, age, lifestyle, and environmental factors. They are typically diagnosed through a combination of medical history, physical examination, laboratory tests, and imaging studies. Treatment options for neurodegenerative diseases vary depending on the specific condition and its underlying causes, but may include medications, therapy, and lifestyle changes.

Preventing or slowing the progression of neurodegenerative diseases is a major focus of current research, with various potential therapeutic strategies being explored, such as:

1. Stem cell therapies: Using stem cells to replace damaged neurons and restore brain function.
2. Gene therapies: Replacing or editing genes that are linked to neurodegenerative diseases.
3. Small molecule therapies: Developing small molecules that can slow or prevent the progression of neurodegenerative diseases.
4. Immunotherapies: Harnessing the immune system to combat neurodegenerative diseases.
5. Lifestyle interventions: Promoting healthy lifestyle choices, such as regular exercise and a balanced diet, to reduce the risk of developing neurodegenerative diseases.

In conclusion, neurodegenerative diseases are a complex and diverse group of disorders that can have a profound impact on individuals and society. While there is currently no cure for these conditions, research is providing new insights into their causes and potential treatments. By continuing to invest in research and developing innovative therapeutic strategies, we can work towards improving the lives of those affected by neurodegenerative diseases and ultimately finding a cure.

Coronaviruses are a group of viruses that can cause a range of respiratory illnesses, from the common cold to severe diseases such as Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). Coronavirus infections are caused by one of the four subtypes of coronaviruses: alpha, beta, gamma, and delta.

The symptoms of coronavirus infections can range from mild to severe and may include:

* Fever
* Cough
* Shortness of breath or difficulty breathing
* Chest tightness or discomfort
* Headache
* Sore throat
* Runny nose or stuffy nose
* Body aches or muscle pains
* Diarrhea
* Nausea or vomiting

In severe cases, coronavirus infections can lead to pneumonia, acute respiratory distress syndrome (ARDS), and even death. The virus is primarily spread through close contact with an infected person, such as touching, shaking hands, or kissing. It can also be spread by touching contaminated surfaces and objects, such as door handles, light switches, and countertops.

There are several ways to diagnose coronavirus infections, including:

* Physical examination and medical history
* Chest X-ray or CT scan
* Blood tests
* Nucleic acid test (NAT)

Treatment for coronavirus infections is primarily focused on relieving symptoms and supporting the body's immune system. This may include:

* Antiviral medications
* Oxygen therapy
* Pain relief medication
* Rest and hydration

Prevention is key to avoiding coronavirus infections, and this includes:

* Washing hands frequently with soap and water
* Using alcohol-based hand sanitizers
* Avoiding close contact with people who are sick
* Covering the mouth and nose when coughing or sneezing
* Staying home when sick

There are also several vaccines currently being developed to protect against coronavirus infections, but these are not yet widely available. It is important to follow the guidance of public health authorities and take precautions to prevent the spread of the virus.

The symptoms of a brain abscess can vary depending on the location and size of the abscess, but may include:

* Headache
* Fever
* Confusion or disorientation
* Seizures
* Weakness or numbness in the arms or legs
* Vision problems
* Speech difficulties

If a brain abscess is suspected, a doctor will typically perform a physical examination and order imaging tests such as CT or MRI scans to confirm the diagnosis. Treatment usually involves antibiotics to treat the underlying infection, as well as surgery to drain the abscess and remove any infected tissue. In severe cases, hospitalization may be necessary to monitor and treat the patient.

With prompt and appropriate treatment, most people with a brain abscess can recover fully or almost fully, but in some cases, the condition can result in long-term complications such as memory loss, cognitive impairment, or personality changes. In rare instances, a brain abscess can be fatal if not treated promptly and properly.

Some common autoimmune diseases of the nervous system include:

1. Multiple sclerosis (MS): A chronic condition that affects the brain, spinal cord, and optic nerves, causing a range of symptoms including numbness, weakness, and vision problems.
2. Neuromyelitis optica (NMO): A rare condition that causes inflammation in the optic nerves and spinal cord, leading to vision loss and muscle weakness.
3. Guillain-Barré syndrome: A rare autoimmune disorder that causes muscle weakness and paralysis, often after a viral infection.
4. Chronic inflammatory demyelinating polyneuropathy (CIDP): A chronic condition that affects the peripheral nerves, causing numbness, weakness, and pain in the hands and feet.
5. Acute disseminated encephalomyelitis (ADEM): A rare condition that causes inflammation in the brain and spinal cord, leading to a range of symptoms including fever, headache, and muscle weakness.

The exact cause of autoimmune diseases of the nervous system is not fully understood, but they are believed to be triggered by a combination of genetic and environmental factors. Treatment options vary depending on the specific condition, but may include medications to reduce inflammation and modulate the immune system, as well as physical therapy and lifestyle modifications.

There are many different types of seizures, each with its own unique set of symptoms. Some common types of seizures include:

1. Generalized seizures: These seizures affect both sides of the brain and can cause a range of symptoms, including convulsions, loss of consciousness, and muscle stiffness.
2. Focal seizures: These seizures affect only one part of the brain and can cause more specific symptoms, such as weakness or numbness in a limb, or changes in sensation or vision.
3. Tonic-clonic seizures: These seizures are also known as grand mal seizures and can cause convulsions, loss of consciousness, and muscle stiffness.
4. Absence seizures: These seizures are also known as petit mal seizures and can cause a brief loss of consciousness or staring spell.
5. Myoclonic seizures: These seizures can cause sudden, brief muscle jerks or twitches.
6. Atonic seizures: These seizures can cause a sudden loss of muscle tone, which can lead to falls or drops.
7. Lennox-Gastaut syndrome: This is a rare and severe form of epilepsy that can cause multiple types of seizures, including tonic, atonic, and myoclonic seizures.

Seizures can be diagnosed through a combination of medical history, physical examination, and diagnostic tests such as electroencephalography (EEG) or imaging studies. Treatment for seizures usually involves anticonvulsant medications, but in some cases, surgery or other interventions may be necessary.

Overall, seizures are a complex and multifaceted symptom that can have a significant impact on an individual's quality of life. It is important to seek medical attention if you or someone you know is experiencing seizures, as early diagnosis and treatment can help to improve outcomes and reduce the risk of complications.

Some examples of nervous system malformations include:

1. Neural tube defects: These are among the most common types of nervous system malformations and occur when the neural tube, which forms the brain and spinal cord, fails to close properly during fetal development. Examples include anencephaly (absence of a major portion of the brain), spina bifida (incomplete closure of the spine), and encephalocele (protrusion of the brain or meninges through a skull defect).
2. Cerebral palsy: This is a group of disorders that affect movement, balance, and posture, often resulting from brain damage during fetal development or early childhood. The exact cause may not be known, but it can be related to genetic mutations, infections, or other factors.
3. Hydrocephalus: This is a condition in which there is an abnormal accumulation of cerebrospinal fluid (CSF) in the brain, leading to increased pressure and enlargement of the head. It can be caused by a variety of factors, including genetic mutations, infections, or blockages in the CSF circulatory system.
4. Moyamoya disease: This is a rare condition caused by narrowing or blockage of the internal carotid artery and its branches, leading to reduced blood flow to the brain. It can result in stroke-like episodes, seizures, and cognitive impairment.
5. Spinal muscular atrophy: This is a genetic disorder that affects the nerve cells responsible for controlling voluntary muscle movement, leading to progressive muscle weakness and wasting. It can be diagnosed through blood tests or genetic analysis.
6. Neurofibromatosis: This is a genetic disorder that causes non-cancerous tumors to grow on nerve tissue, leading to symptoms such as skin changes, learning disabilities, and eye problems. It can be diagnosed through clinical evaluation and genetic testing.
7. Tuberous sclerosis: This is a rare genetic disorder that causes non-cancerous tumors to grow in the brain and other organs, leading to symptoms such as seizures, developmental delays, and skin changes. It can be diagnosed through clinical evaluation, imaging studies, and genetic testing.
8. Cerebral palsy: This is a group of disorders that affect movement, posture, and muscle tone, often resulting from brain damage sustained during fetal development or early childhood. It can be caused by a variety of factors, including premature birth, infections, and genetic mutations.
9. Down syndrome: This is a genetic disorder caused by an extra copy of chromosome 21, leading to intellectual disability, developmental delays, and physical characteristics such as a flat face and short stature. It can be diagnosed through blood tests or genetic analysis.
10. William syndrome: This is a rare genetic disorder caused by a deletion of genetic material on chromosome 7, leading to symptoms such as cardiovascular problems, growth delays, and learning disabilities. It can be diagnosed through clinical evaluation and genetic testing.

It's important to note that these are just a few examples of developmental disorders, and there are many other conditions that can affect cognitive and physical development in children. If you suspect your child may have a developmental disorder, it's important to speak with a qualified healthcare professional for an accurate diagnosis and appropriate treatment.

There are several types of lymphoma, including:

1. Hodgkin lymphoma: This is a type of lymphoma that originates in the white blood cells called Reed-Sternberg cells. It is characterized by the presence of giant cells with multiple nucleoli.
2. Non-Hodgkin lymphoma (NHL): This is a type of lymphoma that does not meet the criteria for Hodgkin lymphoma. There are many subtypes of NHL, each with its own unique characteristics and behaviors.
3. Cutaneous lymphoma: This type of lymphoma affects the skin and can take several forms, including cutaneous B-cell lymphoma and cutaneous T-cell lymphoma.
4. Primary central nervous system (CNS) lymphoma: This is a rare type of lymphoma that develops in the brain or spinal cord.
5. Post-transplantation lymphoproliferative disorder (PTLD): This is a type of lymphoma that develops in people who have undergone an organ transplant, often as a result of immunosuppressive therapy.

The symptoms of lymphoma can vary depending on the type and location of the cancer. Some common symptoms include:

* Swollen lymph nodes
* Fever
* Fatigue
* Weight loss
* Night sweats
* Itching

Lymphoma is diagnosed through a combination of physical examination, imaging tests (such as CT scans or PET scans), and biopsies. Treatment options for lymphoma depend on the type and stage of the cancer, and may include chemotherapy, radiation therapy, immunotherapy, or stem cell transplantation.

Overall, lymphoma is a complex and diverse group of cancers that can affect people of all ages and backgrounds. While it can be challenging to diagnose and treat, advances in medical technology and research have improved the outlook for many patients with lymphoma.

The symptoms of CNS helminthiasis can vary depending on the type of worm present, but may include:

* Seizures
* Headaches
* Vision problems
* Weakness or paralysis
* Confusion or disorientation
* Personality changes

CNS helminthiasis is caused by a variety of parasites, including tapeworms, roundworms, and hookworms. These worms can enter the body through contaminated food or water, or through contact with an infected person or animal.

The diagnosis of CNS helminthiasis typically involves a combination of physical examination, medical history, and laboratory tests such as blood tests or imaging studies (e.g., CT or MRI scans). Treatment usually involves anti-parasitic medications to kill the worms, and may also include supportive care to manage symptoms.

Preventive measures to avoid CNS helminthiasis include:

* Avoiding undercooked meat, especially pork and wild game
* Avoiding raw or undercooked fish and shellfish
* Avoiding contact with animals that may be infected
* Properly storing and cooking food to kill parasites
* Avoiding drinking untreated water
* Washing hands and fruits/vegetables before eating

Overall, CNS helminthiasis is a serious condition that can cause significant neurological symptoms. Prompt diagnosis and treatment are essential to prevent long-term damage and improve outcomes.

The most common symptoms of enterovirus infections include:

* Diarrhea
* Vomiting
* Fever
* Abdominal pain
* Headache
* Fatigue

In some cases, enterovirus infections can lead to more severe complications, such as:

* Hand, foot, and mouth disease (HFMD)
* Aseptic meningitis
* Encephalitis
* Myocarditis

Enteroviruses are highly contagious and can be spread through:

* Close contact with an infected person
* Contaminated food and water
* Insect vectors

There is no specific treatment for enterovirus infections, but symptoms can be managed with supportive care, such as hydration, rest, and pain relief. Antiviral medications may be used in severe cases.

Prevention measures include:

* Good hygiene practices, such as frequent handwashing
* Avoiding close contact with people who are sick
* Properly preparing and storing food and water
* Avoiding sharing items that come into contact with the mouth, such as utensils and drinking glasses.

There are several subtypes of astrocytoma, including:

1. Low-grade astrocytoma: These tumors grow slowly and are less aggressive. They can be treated with surgery, radiation therapy, or chemotherapy.
2. High-grade astrocytoma: These tumors grow more quickly and are more aggressive. They are often resistant to treatment and may recur after initial treatment.
3. Anaplastic astrocytoma: These are the most aggressive type of astrocytoma, growing rapidly and spreading to other parts of the brain.
4. Glioblastoma (GBM): This is the most common and deadliest type of primary brain cancer, accounting for 55% of all astrocytomas. It is highly aggressive and resistant to treatment, often recurring after initial surgery, radiation, and chemotherapy.

The symptoms of astrocytoma depend on the location and size of the tumor. Common symptoms include headaches, seizures, weakness or numbness in the arms or legs, and changes in personality or behavior.

Astrocytomas are diagnosed through a combination of imaging tests such as MRI or CT scans, and tissue biopsy. Treatment options vary depending on the type and location of the tumor, but may include surgery, radiation therapy, chemotherapy, or a combination of these.

The prognosis for astrocytoma varies based on the subtype and location of the tumor, as well as the patient's age and overall health. In general, low-grade astrocytomas have a better prognosis than high-grade tumors. However, even with treatment, the survival rate for astrocytoma is generally lower compared to other types of cancer.

There are several types of CNS parasitic infections, including:

1. Toxoplasmosis: This is caused by the Toxoplasma gondii parasite and can lead to a variety of symptoms, including headaches, fatigue, and changes in behavior or cognitive function.
2. Cerebral cysticercosis: This is caused by the Taenia solium parasite and can cause seizures, headaches, and other neurological symptoms.
3. Neurocysticercosis: This is caused by the Taenia solium parasite and can cause seizures, headaches, and other neurological symptoms.
4. Angiostrongyliasis: This is caused by the Angiostrongylus cantonensis parasite and can cause eosinophilic meningitis, which is an inflammation of the membranes surrounding the brain and spinal cord.
5. Schistosomiasis: This is caused by blood flukes (Schistosoma spp.) and can cause neurological symptoms such as headaches, seizures, and changes in behavior or cognitive function.

These infections are typically diagnosed through a combination of physical examination, laboratory tests, and imaging studies such as CT or MRI scans. Treatment options vary depending on the specific type of infection and can include antiparasitic medications, anticonvulsants, and supportive care such as pain management and rehabilitation therapy.

In conclusion, central nervous system parasitic infections are a significant public health concern and can have serious consequences if left untreated. It is important to be aware of the risk factors for these infections and to seek medical attention if symptoms persist or worsen over time. Early diagnosis and treatment can help prevent long-term neurological damage and improve outcomes for patients infected with these parasites.

There are several key features of inflammation:

1. Increased blood flow: Blood vessels in the affected area dilate, allowing more blood to flow into the tissue and bringing with it immune cells, nutrients, and other signaling molecules.
2. Leukocyte migration: White blood cells, such as neutrophils and monocytes, migrate towards the site of inflammation in response to chemical signals.
3. Release of mediators: Inflammatory mediators, such as cytokines and chemokines, are released by immune cells and other cells in the affected tissue. These molecules help to coordinate the immune response and attract more immune cells to the site of inflammation.
4. Activation of immune cells: Immune cells, such as macrophages and T cells, become activated and start to phagocytose (engulf) pathogens or damaged tissue.
5. Increased heat production: Inflammation can cause an increase in metabolic activity in the affected tissue, leading to increased heat production.
6. Redness and swelling: Increased blood flow and leakiness of blood vessels can cause redness and swelling in the affected area.
7. Pain: Inflammation can cause pain through the activation of nociceptors (pain-sensing neurons) and the release of pro-inflammatory mediators.

Inflammation can be acute or chronic. Acute inflammation is a short-term response to injury or infection, which helps to resolve the issue quickly. Chronic inflammation is a long-term response that can cause ongoing damage and diseases such as arthritis, asthma, and cancer.

There are several types of inflammation, including:

1. Acute inflammation: A short-term response to injury or infection.
2. Chronic inflammation: A long-term response that can cause ongoing damage and diseases.
3. Autoimmune inflammation: An inappropriate immune response against the body's own tissues.
4. Allergic inflammation: An immune response to a harmless substance, such as pollen or dust mites.
5. Parasitic inflammation: An immune response to parasites, such as worms or fungi.
6. Bacterial inflammation: An immune response to bacteria.
7. Viral inflammation: An immune response to viruses.
8. Fungal inflammation: An immune response to fungi.

There are several ways to reduce inflammation, including:

1. Medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and disease-modifying anti-rheumatic drugs (DMARDs).
2. Lifestyle changes, such as a healthy diet, regular exercise, stress management, and getting enough sleep.
3. Alternative therapies, such as acupuncture, herbal supplements, and mind-body practices.
4. Addressing underlying conditions, such as hormonal imbalances, gut health issues, and chronic infections.
5. Using anti-inflammatory compounds found in certain foods, such as omega-3 fatty acids, turmeric, and ginger.

It's important to note that chronic inflammation can lead to a range of health problems, including:

1. Arthritis
2. Diabetes
3. Heart disease
4. Cancer
5. Alzheimer's disease
6. Parkinson's disease
7. Autoimmune disorders, such as lupus and rheumatoid arthritis.

Therefore, it's important to manage inflammation effectively to prevent these complications and improve overall health and well-being.

Meningioma can occur in various locations within the brain, including the cerebrum, cerebellum, brainstem, and spinal cord. The most common type of meningioma is the meningothelial meningioma, which arises from the arachnoid membrane, one of the three layers of the meninges. Other types of meningioma include the dural-based meningioma, which originates from the dura mater, and the fibrous-cap meningioma, which is characterized by a fibrous cap covering the tumor.

The symptoms of meningioma can vary depending on the location and size of the tumor, but they often include headaches, seizures, weakness or numbness in the arms or legs, and changes in vision, memory, or cognitive function. As the tumor grows, it can compress the brain tissue and cause damage to the surrounding structures, leading to more severe symptoms such as difficulty speaking, walking, or controlling movement.

The diagnosis of meningioma typically involves a combination of imaging studies such as MRI or CT scans, and tissue sampling through biopsy or surgery. Treatment options for meningioma depend on the size, location, and aggressiveness of the tumor, but may include surgery, radiation therapy, and chemotherapy. Overall, the prognosis for meningioma is generally good, with many patients experiencing a good outcome after treatment. However, some types of meningioma can be more aggressive and difficult to treat, and the tumor may recur in some cases.

Some common examples of spinal cord diseases include:

1. Spinal muscular atrophy: This is a genetic disorder that affects the nerve cells responsible for controlling voluntary muscle movement. It can cause muscle weakness and wasting, as well as other symptoms such as respiratory problems and difficulty swallowing.
2. Multiple sclerosis: This is an autoimmune disease that causes inflammation and damage to the protective covering of nerve fibers in the spinal cord. Symptoms can include vision problems, muscle weakness, balance and coordination difficulties, and cognitive impairment.
3. Spinal cord injuries: These can occur as a result of trauma, such as a car accident or a fall, and can cause a range of symptoms including paralysis, numbness, and loss of sensation below the level of the injury.
4. Spinal stenosis: This is a condition in which the spinal canal narrows, putting pressure on the spinal cord and nerve roots. Symptoms can include back pain, leg pain, and difficulty walking or standing for long periods.
5. Tumors: Benign or malignant tumors can grow in the spinal cord, causing a range of symptoms including pain, weakness, and numbness or tingling in the limbs.
6. Infections: Bacterial, viral, or fungal infections can cause inflammation and damage to the spinal cord, leading to symptoms such as fever, headache, and muscle weakness.
7. Degenerative diseases: Conditions such as amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) can cause progressive degeneration of the spinal cord nerve cells, leading to muscle weakness, twitching, and wasting.
8. Trauma: Traumatic injuries, such as those caused by sports injuries or physical assault, can damage the spinal cord and result in a range of symptoms including pain, numbness, and weakness.
9. Ischemia: Reduced blood flow to the spinal cord can cause tissue damage and lead to symptoms such as weakness, numbness, and paralysis.
10. Spinal cord infarction: A blockage in the blood vessels that supply the spinal cord can cause tissue damage and lead to symptoms similar to those of ischemia.

It's important to note that some of these conditions can be caused by a combination of factors, such as genetics, age, lifestyle, and environmental factors. It's also worth noting that some of these conditions can have a significant impact on quality of life, and in some cases, may be fatal.

The tumor develops from immature cells in the cerebellum called granule cells, and it can grow rapidly and spread to other parts of the brain. Medulloblastoma is usually diagnosed in the early stages, and treatment typically involves surgery, chemotherapy, and radiation therapy.

There are several subtypes of medulloblastoma, including:

* Winged-helix transcription factor (WHCT) medulloblastoma
* Sonic hedgehog (SHH) medulloblastoma
* Group 3 medulloblastoma
* Group 4 medulloblastoma

Each subtype has a different genetic profile and may require different treatment approaches.

Medulloblastoma is a rare cancer, but it is the most common type of pediatric brain cancer. With current treatments, the prognosis for medulloblastoma is generally good, especially for children who are diagnosed early and receive appropriate treatment. However, the cancer can recur in some cases, and ongoing research is focused on improving treatment outcomes and finding new, less toxic therapies for this disease.

Hemangioblastomas are typically slow-growing and benign, but they can sometimes become malignant and invade nearby tissues or spread to other parts of the body (metastasize). They can cause a variety of symptoms depending on their location, such as headaches, seizures, weakness or numbness, and vision changes.

The exact cause of hemangioblastoma is not known, but it is believed to be related to genetic mutations that occur during fetal development. It is usually diagnosed by a combination of imaging studies such as CT or MRI scans, and tissue sampling through biopsy. Treatment options for hemangioblastoma depend on the location and severity of the tumor, and may include observation, surgery, radiation therapy, or chemotherapy.

There are several types of gliomas, including:

1. Astrocytoma: This is the most common type of glioma, accounting for about 50% of all cases. It arises from the star-shaped cells called astrocytes that provide support and nutrients to the brain's nerve cells.
2. Oligodendroglioma: This type of glioma originates from the oligodendrocytes, which are responsible for producing the fatty substance called myelin that insulates the nerve fibers.
3. Glioblastoma (GBM): This is the most aggressive and malignant type of glioma, accounting for about 70% of all cases. It is fast-growing and often spreads to other parts of the brain.
4. Brain stem glioma: This type of glioma arises in the brain stem, which is responsible for controlling many of the body's vital functions such as breathing, heart rate, and blood pressure.

The symptoms of glioma depend on the location and size of the tumor. Common symptoms include headaches, seizures, weakness or numbness in the arms or legs, and changes in personality, memory, or speech.

Gliomas are diagnosed through a combination of imaging tests such as CT or MRI scans, and tissue biopsy to confirm the presence of cancer cells. Treatment options for glioma depend on the type and location of the tumor, as well as the patient's overall health. Surgery is often the first line of treatment to remove as much of the tumor as possible, followed by radiation therapy and/or chemotherapy to kill any remaining cancer cells.

The prognosis for glioma patients varies depending on the type and location of the tumor, as well as the patient's overall health. In general, the prognosis is better for patients with slow-growing, low-grade tumors, while those with fast-growing, high-grade tumors have a poorer prognosis. Overall, the 5-year survival rate for glioma patients is around 30-40%.

Cardiovirus infections are a type of viral infection that affects the heart muscle, leading to cardiomyopathy and potentially heart failure. The most common cause of cardiovirus infections is the adenovirus, which is a common virus that can infect people of all ages.

Symptoms of Cardiovirus Infections:

The symptoms of cardiovirus infections can vary depending on the severity of the infection and the individual's overall health. Common symptoms include:

* Chest pain or discomfort
* Shortness of breath
* Fatigue
* Swelling of the legs, ankles, and feet
* Fast or irregular heartbeat
* Low blood pressure

Diagnosis of Cardiovirus Infections:

To diagnose a cardiovirus infection, a healthcare provider will typically perform a physical examination and ask about the individual's symptoms. They may also order one or more diagnostic tests, such as:

* Electrocardiogram (ECG) to measure the heart's electrical activity
* Echocardiogram to visualize the heart and its function
* Blood tests to look for signs of inflammation or cardiac damage

Treatment of Cardiovirus Infections:

There is no specific treatment for cardiovirus infections, but the following treatments may be recommended to manage symptoms and prevent complications:

* Rest and avoiding strenuous activities
* Medications to control heart rate and rhythm
* Diuretics to reduce fluid buildup in the body
* Oxygen therapy to improve oxygen levels in the blood

Prevention of Cardiovirus Infections:

Preventing cardiovirus infections is challenging, but taking steps to avoid exposure can help reduce the risk. These steps include:

* Practicing good hygiene, such as washing hands frequently and avoiding close contact with people who are sick
* Avoiding sharing food, drinks, or personal items with people who are sick
* Covering the mouth and nose when coughing or sneezing
* Staying home from work or school if experiencing symptoms

It is important to note that cardiovirus infections can be severe and potentially life-threatening, especially for certain populations such as older adults, young children, and people with underlying heart conditions. If you suspect you or someone else may have a cardiovirus infection, it is essential to seek medical attention right away.

Symptoms of rhabdoid tumor may include abdominal pain, fever, weight loss, and difficulty with movement or coordination. The exact cause of rhabdoid tumors is not well understood, but genetic mutations are thought to play a role in their development. Treatment typically involves a combination of surgery, chemotherapy, and radiation therapy. The prognosis for rhabdoid tumors is generally poor, with a survival rate of approximately 30-40%.

Rhabdoid tumor is also known as "rhabdoid sarcoma" or "infantile fibrosarcoma." It is important to note that while this condition is rare, it can be difficult to diagnose and treat due to its aggressive nature and the limited understanding of its causes.

There are several types of hereditary central nervous system demyelinating diseases, including:

1. Adrenoleukodystrophy (ALD): A genetic disorder that affects the breakdown of fatty acids in the body, leading to the accumulation of toxic substances in the brain and progressive damage to the myelin sheath.
2. Metachromatic leukodystrophy (MLD): A genetic disorder caused by a deficiency of the enzyme arylsulfatase A, which is necessary for the breakdown of sulfatides in the brain. Accumulation of sulfatides leads to progressive damage to the myelin sheath.
3. Krabbe disease: A rare genetic disorder caused by a deficiency of the enzyme galactocerebrosidase, which is necessary for the breakdown of certain fatty substances in the brain. Accumulation of these substances leads to progressive damage to the myelin sheath.
4. Niemann-Pick disease: A group of rare genetic disorders caused by a deficiency of enzymes involved in the breakdown of lipids (fatty substances) in the brain. Accumulation of these substances leads to progressive damage to the myelin sheath.
5. Pelizaeus-Merzbacher disease: A rare genetic disorder caused by a deficiency of the protein proteolipid protein (PLP), which is necessary for the maintenance of the myelin sheath in the CNS.

These diseases can be diagnosed through a combination of clinical evaluation, laboratory tests such as blood and urine tests, and imaging studies such as MRI and CT scans. Treatment options vary depending on the specific disease and may include enzyme replacement therapy, bone marrow transplantation, and supportive care to manage symptoms and slow disease progression.

In summary, leukodystrophies are a group of genetic disorders characterized by progressive damage to the myelin sheath in the CNS, leading to a range of cognitive, motor, and behavioral symptoms. These diseases can be caused by mutations in various genes involved in myelin synthesis and maintenance, and can be diagnosed through a combination of clinical evaluation and laboratory tests. Treatment options vary depending on the specific disease and may include enzyme replacement therapy, bone marrow transplantation, and supportive care to manage symptoms and slow disease progression.

Primitive neuroectodermal tumors are a type of neuroectodermal tumor that is thought to arise from primitive neural cells, which are the earliest forms of brain cells. These tumors tend to be more aggressive than other types of neuroectodermal tumors and have a poorer prognosis.

Some common features of primitive neuroectodermal tumors include:

* They usually occur in children and young adults, although they can occur at any age.
* They tend to be located in the central nervous system, particularly in the brain or spine.
* They are often large and can grow rapidly.
* They can cause a variety of symptoms depending on their location, including headaches, seizures, weakness or numbness in the arms or legs, and changes in vision, balance, or coordination.
* They are often diagnosed using imaging tests such as CT or MRI scans, and a biopsy may be performed to confirm the diagnosis.
* Treatment typically involves surgery to remove as much of the tumor as possible, followed by radiation therapy and chemotherapy to kill any remaining cancer cells.

Overall, primitive neuroectodermal tumors are rare and aggressive brain tumors that can occur in both children and adults. They tend to be more difficult to treat than other types of brain tumors, but with the help of advanced medical techniques and a multidisciplinary team of healthcare professionals, it is possible to improve outcomes for patients with these tumors.

Sources:

1. "Primitive Neuroectodermal Tumors." American Brain Tumor Association, 2022, .
2. "Primitive Neuroectodermal Tumors (PNETs)." Childhood Brain Tumor Foundation, 2022, .
3. "Primitive Neuroectodermal Tumors (PNETs) in Adults." Cancer Research UK, 2022, .

There are several different types of spinal cord injuries that can occur, depending on the location and severity of the damage. These include:

1. Complete spinal cord injuries: In these cases, the spinal cord is completely severed, resulting in a loss of all sensation and function below the level of the injury.
2. Incomplete spinal cord injuries: In these cases, the spinal cord is only partially damaged, resulting in some remaining sensation and function below the level of the injury.
3. Brown-Sequard syndrome: This is a specific type of incomplete spinal cord injury that affects one side of the spinal cord, resulting in weakness or paralysis on one side of the body.
4. Conus medullaris syndrome: This is a type of incomplete spinal cord injury that affects the lower part of the spinal cord, resulting in weakness or paralysis in the legs and bladder dysfunction.

The symptoms of spinal cord injuries can vary depending on the location and severity of the injury. They may include:

* Loss of sensation in the arms, legs, or other parts of the body
* Weakness or paralysis in the arms, legs, or other parts of the body
* Difficulty walking or standing
* Difficulty with bowel and bladder function
* Numbness or tingling sensations
* Pain or pressure in the neck or back

Treatment for spinal cord injuries typically involves a combination of medical and rehabilitative therapies. Medical treatments may include:

* Immobilization of the spine to prevent further injury
* Medications to manage pain and inflammation
* Surgery to relieve compression or stabilize the spine

Rehabilitative therapies may include:

* Physical therapy to improve strength and mobility
* Occupational therapy to learn new ways of performing daily activities
* Speech therapy to improve communication skills
* Psychological counseling to cope with the emotional effects of the injury.

Overall, the prognosis for spinal cord injuries depends on the severity and location of the injury, as well as the age and overall health of the individual. While some individuals may experience significant recovery, others may experience long-term or permanent impairment. It is important to seek medical attention immediately if symptoms of a spinal cord injury are present.

Symptoms of cerebellar neoplasms can include:

* Headaches
* Nausea and vomiting
* Dizziness and loss of balance
* Weakness or paralysis in the arms or legs
* Coordination problems and difficulty walking
* Double vision or other visual disturbances
* Speech difficulties
* Seizures

Cerebellar neoplasms can be caused by genetic mutations, exposure to radiation, or viral infections. They can also occur spontaneously without any known cause.

Diagnosis of cerebellar neoplasms usually involves a combination of imaging tests such as CT or MRI scans, and tissue sampling through biopsy. Treatment options for cerebellar neoplasms depend on the type, size, and location of the tumor, as well as the patient's overall health.

Treatment options may include:

* Surgery to remove the tumor
* Radiation therapy to kill remaining cancer cells
* Chemotherapy to kill cancer cells
* Targeted therapy to attack specific molecules that are involved in the growth and spread of the tumor.

Prognosis for cerebellar neoplasms varies depending on the type, size, and location of the tumor, as well as the patient's overall health. In general, the prognosis is better for patients with benign tumors that are located in the outer layers of the cerebellum, and worse for those with malignant tumors that are located in the deeper layers.

Overall, cerebellar neoplasms are a complex and rare type of brain tumor that require specialized care and treatment from a team of medical professionals.

The infection occurs when the parasite migrates through the body and reaches the CNS, where it forms cysticerci, which are fluid-filled structures that can cause inflammation and damage to brain tissue. The symptoms of neurocysticercosis can vary depending on the location and size of the cysts, but they often include seizures, headaches, weakness, and vision problems.

Diagnosis of neurocysticercosis is based on a combination of clinical findings, imaging studies (such as CT or MRI scans), and serological tests to detect antibodies against the parasite. Treatment typically involves antiparasitic drugs to kill the parasites, as well as supportive care to manage symptoms and prevent complications.

Prevention of neurocysticercosis primarily involves controlling the transmission of the parasite, which can be done by improving food hygiene and avoiding consumption of undercooked or raw pork. In areas where the infection is common, mass drug administration programs have also been implemented to reduce the prevalence of the parasite.

In summary, neurocysticercosis is a severe and potentially debilitating parasitic infection that affects the central nervous system, with symptoms ranging from seizures to vision problems. Diagnosis is based on a combination of clinical findings and imaging studies, and treatment involves antiparasitic drugs and supportive care. Prevention primarily involves controlling the transmission of the parasite through improved food hygiene and mass drug administration programs.

The different types of Neurotoxicity Syndromes include:

1. Organophosphate-induced neurotoxicity: This syndrome is caused by exposure to organophosphate pesticides, which can damage the nervous system and cause symptoms such as headaches, dizziness, and memory loss.
2. Heavy metal neurotoxicity: Exposure to heavy metals, such as lead, mercury, and arsenic, can damage the nervous system and cause symptoms such as tremors, muscle weakness, and cognitive impairment.
3. Pesticide-induced neurotoxicity: This syndrome is caused by exposure to pesticides, which can damage the nervous system and cause symptoms such as headaches, dizziness, and memory loss.
4. Solvent-induced neurotoxicity: Exposure to solvents, such as toluene and benzene, can damage the nervous system and cause symptoms such as memory loss, difficulty with concentration, and mood changes.
5. Medication-induced neurotoxicity: Certain medications, such as antidepressants and antipsychotics, can damage the nervous system and cause symptoms such as tremors, muscle rigidity, and cognitive impairment.
6. Environmental neurotoxicity: Exposure to environmental toxins, such as air pollution and pesticides, can damage the nervous system and cause symptoms such as headaches, dizziness, and memory loss.
7. Neurodegenerative disease-induced neurotoxicity: Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, can cause neurotoxicity and lead to symptoms such as cognitive decline, memory loss, and motor dysfunction.
8. Traumatic brain injury-induced neurotoxicity: Traumatic brain injury can cause neurotoxicity and lead to symptoms such as cognitive impairment, memory loss, and mood changes.
9. Stroke-induced neurotoxicity: A stroke can cause neurotoxicity and lead to symptoms such as weakness or paralysis on one side of the body, difficulty with speech and language, and memory loss.
10. Neurodevelopmental disorder-induced neurotoxicity: Neurodevelopmental disorders, such as autism spectrum disorder, can cause neurotoxicity and lead to symptoms such as cognitive impairment, social withdrawal, and repetitive behaviors.

It is important to note that these are just a few examples of the many different types of neurotoxicity that can occur, and that each type may have its own unique set of causes, symptoms, and treatments. If you suspect that you or someone you know may be experiencing neurotoxicity, it is important to seek medical attention as soon as possible in order to receive an accurate diagnosis and appropriate treatment.

The symptoms of an ependymoma depend on its location and size, but may include headaches, nausea, vomiting, seizures, and problems with balance and coordination. The diagnosis of an ependymoma is made through a combination of imaging tests such as CT or MRI scans, and a biopsy to confirm the presence of cancer cells.

Treatment for an ependymoma may involve surgery to remove the tumor, followed by radiation therapy and/or chemotherapy to kill any remaining cancer cells. The prognosis for this condition depends on the location and size of the tumor, as well as the age of the patient. In general, children have a better prognosis than adults, and patients with benign ependymomas have a good outlook. However, malignant ependymomas can be more difficult to treat and may have a poorer outcome.

Ependymoma accounts for about 5% of all primary brain tumors, which means they originate in the brain rather than spreading from another part of the body. They are relatively rare, making up only about 1-2% of all childhood brain tumors. However, they can occur at any age and can be a significant source of morbidity and mortality if not properly treated.

There are several subtypes of ependymoma, including:

1. Papillary ependymoma: This is the most common type of ependymoma and typically affects children. It grows slowly and is usually benign.
2. Fibrillary ependymoma: This type of ependymoma is more aggressive than papillary ependymoma and can be malignant. It is less common in children and more common in adults.
3. Anaplastic ependymoma: This is the most malignant type of ependymoma and tends to affect older adults. It grows quickly and can spread to other parts of the brain.

The symptoms of ependymoma vary depending on the location and size of the tumor. Common symptoms include headaches, seizures, nausea, vomiting, and changes in personality or cognitive function. Treatment for ependymoma usually involves a combination of surgery, radiation therapy, and chemotherapy. The prognosis for ependymoma depends on the subtype and location of the tumor, as well as the age of the patient. In general, patients with benign ependymomas have a good outlook, while those with malignant ependymomas may have a poorer outcome.

1. Complete paralysis: When there is no movement or sensation in a particular area of the body.
2. Incomplete paralysis: When there is some movement or sensation in a particular area of the body.
3. Localized paralysis: When paralysis affects only a specific part of the body, such as a limb or a facial muscle.
4. Generalized paralysis: When paralysis affects multiple parts of the body.
5. Flaccid paralysis: When there is a loss of muscle tone and the affected limbs feel floppy.
6. Spastic paralysis: When there is an increase in muscle tone and the affected limbs feel stiff and rigid.
7. Paralysis due to nerve damage: This can be caused by injuries, diseases such as multiple sclerosis, or birth defects such as spina bifida.
8. Paralysis due to muscle damage: This can be caused by injuries, such as muscular dystrophy, or diseases such as muscular sarcopenia.
9. Paralysis due to brain damage: This can be caused by head injuries, stroke, or other conditions that affect the brain such as cerebral palsy.
10. Paralysis due to spinal cord injury: This can be caused by trauma, such as a car accident, or diseases such as polio.

Paralysis can have a significant impact on an individual's quality of life, affecting their ability to perform daily activities, work, and participate in social and recreational activities. Treatment options for paralysis depend on the underlying cause and may include physical therapy, medications, surgery, or assistive technologies such as wheelchairs or prosthetic devices.

Symptoms of ES can range from mild to severe and may include fever, headache, confusion, seizures, and changes in behavior or personality. In severe cases, ES can lead to brain damage, coma, and even death.

Diagnosis of ES typically involves a combination of physical examination, medical history, laboratory tests (such as PCR or ELISA), and imaging studies (such as CT or MRI scans). Treatment usually involves antiviral medication and supportive care to manage symptoms and prevent complications.

ES is a serious condition that requires prompt medical attention, especially in severe cases. Early diagnosis and treatment can help reduce the risk of complications and improve outcomes for patients with ES.

The parasite enters the body through the ingestion of contaminated food or water, and can cause a wide range of symptoms in people with healthy immune systems, including fever, headache, and swollen lymph nodes. However, those with compromised immune systems are more susceptible to severe symptoms, including seizures, confusion, and coma.

Diagnosis of cerebral toxoplasmosis is often made through a combination of physical examination, laboratory tests (such as PCR or IgG antibody detection), and imaging studies (such as CT or MRI scans). Treatment typically involves a combination of antiparasitic medications and supportive care to manage symptoms and prevent complications.

In severe cases, cerebral toxoplasmosis can lead to long-term neurological damage, including cognitive impairment and seizure disorders. Prevention of the disease is primarily focused on avoiding exposure to the parasite, which can be achieved through good hygiene practices (such as proper handling and cooking of meat) and avoiding contact with cat feces, which are a common source of infection.

Overall, cerebral toxoplasmosis is a serious opportunistic infection that can have significant neurological consequences in individuals with compromised immune systems. Prompt diagnosis and appropriate treatment are essential for preventing long-term complications and improving outcomes.

The exact cause of ADEM is not fully understood, but it is believed to be triggered by a viral infection or other environmental factors that set off an abnormal immune response. The disease typically affects children, especially those under the age of 10, and is more common in males than females.

The symptoms of ADEM can vary widely depending on the severity of the disease and the areas of the brain affected. Common symptoms include:

* Fever
* Headache
* Confusion or disorientation
* Seizures or convulsions
* Weakness or paralysis in the limbs or other parts of the body
* Difficulty with speech, vision, or hearing
* Poor coordination and balance

ADEM can be difficult to diagnose, as its symptoms are similar to those of other conditions such as multiple sclerosis or meningitis. A definitive diagnosis is usually made through a combination of physical examination, medical history, laboratory tests, and imaging studies such as MRI or CT scans.

There is no cure for ADEM, but treatment focuses on managing the symptoms and preventing further damage to the brain and spinal cord. Corticosteroids are often used to reduce inflammation, and antiviral medications may be prescribed if the disease is thought to be caused by a viral infection. Rehabilitation therapy may also be necessary to help regain lost function and mobility.

The prognosis for ADEM varies depending on the severity of the disease and the age of the patient. In general, children under the age of 5 have a better prognosis than older children and adults. With appropriate treatment, many patients are able to recover significant function and lead active lives. However, some individuals may experience long-term neurological deficits or disability.

Prevention of ADEM is not currently possible, as the exact cause of the disease is not fully understood. However, research is ongoing to identify potential risk factors and develop effective treatments. It is important for parents and caregivers to be aware of the signs and symptoms of ADEM and seek medical attention if they suspect their child may have the condition.

In conclusion, acute disseminated encephalomyelitis (ADEM) is a rare but potentially debilitating autoimmune disease that affects the brain and spinal cord. While the exact cause of ADEM is not fully understood, it is believed to be triggered by a viral infection or other factors. Symptoms can range from mild to severe and include fever, headache, confusion, weakness, and difficulty with speech and coordination. Diagnosis is made through a combination of physical examination, medical history, laboratory tests, and imaging studies such as MRI or CT scans. Treatment focuses on managing symptoms and preventing further damage to the brain and spinal cord, and may include corticosteroids and antiviral medications. While there is no cure for ADEM, early diagnosis and aggressive treatment can improve outcomes for affected children.

There are several different types of brain injuries that can occur, including:

1. Concussions: A concussion is a type of mild traumatic brain injury that occurs when the brain is jolted or shaken, often due to a blow to the head.
2. Contusions: A contusion is a bruise on the brain that can occur when the brain is struck by an object, such as during a car accident.
3. Coup-contrecoup injuries: This type of injury occurs when the brain is injured as a result of the force of the body striking another object, such as during a fall.
4. Penetrating injuries: A penetrating injury occurs when an object pierces the brain, such as during a gunshot wound or stab injury.
5. Blast injuries: This type of injury occurs when the brain is exposed to a sudden and explosive force, such as during a bombing.

The symptoms of brain injuries can vary depending on the severity of the injury and the location of the damage in the brain. Some common symptoms include:

* Headaches
* Dizziness or loss of balance
* Confusion or disorientation
* Memory loss or difficulty with concentration
* Slurred speech or difficulty with communication
* Vision problems, such as blurred vision or double vision
* Sleep disturbances
* Mood changes, such as irritability or depression
* Personality changes
* Difficulty with coordination and balance

In some cases, brain injuries can be treated with medication, physical therapy, and other forms of rehabilitation. However, in more severe cases, the damage may be permanent and long-lasting. It is important to seek medical attention immediately if symptoms persist or worsen over time.

Symptoms of bacterial meningitis may include sudden onset of fever, headache, stiff neck, nausea, vomiting, and sensitivity to light. In severe cases, the infection can cause seizures, coma, and even death.

Bacterial meningitis can be diagnosed through a combination of physical examination, laboratory tests, and imaging studies such as CT or MRI scans. Treatment typically involves antibiotics to eradicate the infection, and supportive care to manage symptoms and prevent complications.

Early diagnosis and treatment are critical to prevent long-term damage and improve outcomes for patients with bacterial meningitis. The disease is more common in certain groups, such as infants, young children, and people with weakened immune systems, and it can be more severe in these populations.

Prevention of bacterial meningitis includes vaccination against the bacteria that most commonly cause the disease, good hand hygiene, and avoiding close contact with people who are sick.

The symptoms of BoD can vary depending on the species of animal infected, but they typically include fever, loss of appetite, lethargy, difficulty walking or standing, seizures, and paralysis. The disease can be fatal in up to 90% of cases, especially in young animals.

BoV is primarily transmitted through the respiratory route, but it can also be spread through contact with infected animals or their tissues. Infected animals can shed the virus for several weeks before showing any symptoms, making it difficult to track the spread of the disease.

There is no specific treatment for BoD, and prevention is largely dependent on controlling the spread of the virus. Vaccination is not always effective against BoV, and there is currently no licensed vaccine available for horses or other animals. However, researchers are working to develop a vaccine that could provide protection against BoV.

In summary, Borna disease is a highly contagious and potentially fatal viral disease that affects animals, particularly horses, sheep, and goats. It is caused by the Borna virus, which can be transmitted through respiratory or contact routes, and there is currently no specific treatment or licensed vaccine available. Prevention relies on controlling the spread of the virus, and researchers are working to develop a vaccine that could provide protection against BoV.

The word "SSPE" is an acronym for the disease name. It stands for "Subacute Sclerosing Panencephalitis."

Here is a list of 10 diseases related to 'Siderosis':

1. Hemochromatosis - A genetic disorder that causes the body to absorb too much iron from food, leading to siderosis and damage to various organs.
2. Sickle Cell Disease - A group of inherited blood disorders that can cause anemia, pain, and a range of complications including siderosis.
3. Thalassemia - A genetic disorder that affects the production of hemoglobin, leading to anemia and other complications such as siderosis.
4. Chronic Blood Transfusions - Repeated blood transfusions can lead to an excessive accumulation of iron in the body, causing siderosis.
5. Iron Overload - Excessive intake of iron-rich foods or supplements can cause iron overload and siderosis.
6. Anemia of Chronic Disease - A type of anemia that occurs in people with chronic diseases such as rheumatoid arthritis, cancer, and HIV/AIDS, which can lead to siderosis.
7. Inherited Iron Overload Disorders - A group of rare genetic disorders that cause the body to absorb too much iron from food, leading to siderosis and other complications.
8. Acquired Iron Overload Disorders - Conditions such as chronic hepatitis C infection and hemodialysis can lead to excessive iron accumulation in the body, causing siderosis.
9. Chronic Inflammation - Prolonged inflammation can lead to an increase in iron absorption, causing siderosis.
10. Poor Nutrition - Consuming a diet low in iron can lead to siderosis over time.

It's important to note that siderosis is a rare condition and these causes are not exhaustive. If you suspect you or someone you know may have siderosis, it's important to consult with a healthcare professional for proper diagnosis and treatment.

Example of how the term 'Lymphoma, AIDS-Related' could be used in a medical context:

"The patient was diagnosed with AIDS-related lymphoma and was started on ART and chemotherapy to treat the cancer."

A type of meningitis caused by a fungal infection. Fungal meningitis is a serious and potentially life-threatening condition that can occur when fungi enter the bloodstream and spread to the membranes surrounding the brain and spinal cord (meninges).

The most common types of fungi that cause fungal meningitis are Aspergillus, Candida, and Cryptococcus. These fungi can be found in soil, decaying organic matter, and contaminated food. People with weakened immune systems, such as those with HIV/AIDS or taking immunosuppressive drugs, are at a higher risk of developing fungal meningitis.

Symptoms of fungal meningitis may include fever, headache, stiff neck, sensitivity to light, and confusion. If left untreated, fungal meningitis can lead to serious complications such as brain damage, hearing loss, and seizures. Treatment typically involves the use of antifungal medications, and in severe cases, surgery may be necessary to remove infected tissue or relieve pressure on the brain.

Preventive measures for fungal meningitis include avoiding exposure to fungal sources, practicing good hygiene, and taking antifungal medications as prescribed by a healthcare professional. Early diagnosis and treatment are critical in preventing serious complications and improving outcomes for patients with fungal meningitis.

Some common neurological manifestations include:

1. Weakness or paralysis of specific muscle groups
2. Numbness or tingling sensations in the limbs or body
3. Difficulty with speech, language, or swallowing
4. Vision problems, such as blurred vision, double vision, or loss of vision
5. Dizziness, vertigo, or loss of balance
6. Confusion, disorientation, or difficulty with memory
7. Seizures or convulsions
8. Headaches or migraines
9. Sleep disturbances, such as insomnia or narcolepsy
10. Behavioral changes, such as mood swings, depression, or anxiety

The neurological manifestations of a condition can vary depending on the underlying cause and the specific location and extent of the damage to the nervous system. Diagnosis and treatment of these manifestations require expertise in neurology and may involve a range of diagnostic tests, such as imaging studies, electromyography, and laboratory tests, as well as medications, surgery, or other interventions.

There are several different types of pain, including:

1. Acute pain: This type of pain is sudden and severe, and it usually lasts for a short period of time. It can be caused by injuries, surgery, or other forms of tissue damage.
2. Chronic pain: This type of pain persists over a long period of time, often lasting more than 3 months. It can be caused by conditions such as arthritis, fibromyalgia, or nerve damage.
3. Neuropathic pain: This type of pain results from damage to the nervous system, and it can be characterized by burning, shooting, or stabbing sensations.
4. Visceral pain: This type of pain originates in the internal organs, and it can be difficult to localize.
5. Psychogenic pain: This type of pain is caused by psychological factors such as stress, anxiety, or depression.

The medical field uses a range of methods to assess and manage pain, including:

1. Pain rating scales: These are numerical scales that patients use to rate the intensity of their pain.
2. Pain diaries: These are records that patients keep to track their pain over time.
3. Clinical interviews: Healthcare providers use these to gather information about the patient's pain experience and other relevant symptoms.
4. Physical examination: This can help healthcare providers identify any underlying causes of pain, such as injuries or inflammation.
5. Imaging studies: These can be used to visualize the body and identify any structural abnormalities that may be contributing to the patient's pain.
6. Medications: There are a wide range of medications available to treat pain, including analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), and muscle relaxants.
7. Alternative therapies: These can include acupuncture, massage, and physical therapy.
8. Interventional procedures: These are minimally invasive procedures that can be used to treat pain, such as nerve blocks and spinal cord stimulation.

It is important for healthcare providers to approach pain management with a multi-modal approach, using a combination of these methods to address the physical, emotional, and social aspects of pain. By doing so, they can help improve the patient's quality of life and reduce their suffering.

Gliosis is made up of glial cells, which are non-neuronal cells that provide support and protection to neurons. When neural tissue is damaged, glial cells proliferate and form a scar-like tissue to fill in the gap and repair the damage. This scar tissue can be made up of astrocytes, oligodendrocytes, or microglia, depending on the type of injury and the location of the damage.

Gliosis can have both beneficial and harmful effects on the brain. On one hand, it can help to prevent further damage by providing a physical barrier against invading substances and protecting the surrounding neural tissue. It can also promote healing by bringing in immune cells and growth factors that aid in the repair process.

On the other hand, gliosis can also have negative effects on brain function. The scar tissue can disrupt normal communication between neurons, leading to impaired cognitive and motor function. In addition, if the scar tissue is too extensive or severe, it can compress or displaces surrounding neural tissue, leading to long-term neurological deficits or even death.

There are several ways to diagnose gliosis, including magnetic resonance imaging (MRI), positron emission tomography (PET), and histopathology. Treatment options for gliosis depend on the underlying cause of the condition and can include medications, surgery, or a combination of both.

In summary, gliosis is a type of scar tissue that forms in the brain and spinal cord as a result of damage to neural tissue. It can have both beneficial and harmful effects on brain function, and diagnosis and treatment options vary depending on the underlying cause of the condition.

There are several types of hydrocephalus, including:

1. Aqueductal stenosis: This occurs when the aqueduct that connects the third and fourth ventricles becomes narrowed or blocked, leading to an accumulation of CSF in the brain.
2. Choroid plexus papilloma: This is a benign tumor that grows on the surface of the choroid plexus, which is a layer of tissue that produces CSF.
3. Hydrocephalus ex vacuo: This occurs when there is a decrease in the volume of brain tissue due to injury or disease, leading to an accumulation of CSF.
4. Normal pressure hydrocephalus (NPH): This is a type of hydrocephalus that occurs in adults and is characterized by an enlarged ventricle, gait disturbances, and cognitive decline, despite normal pressure levels.
5. Symptomatic hydrocephalus: This type of hydrocephalus is caused by other conditions such as brain tumors, cysts, or injuries.

Symptoms of hydrocephalus can include headache, nausea, vomiting, seizures, and difficulty walking or speaking. Treatment options for hydrocephalus depend on the underlying cause and may include medication, surgery, or a shunt to drain excess CSF. In some cases, hydrocephalus can be managed with lifestyle modifications such as regular exercise and a balanced diet.

Prognosis for hydrocephalus varies depending on the underlying cause and severity of the condition. However, with timely diagnosis and appropriate treatment, many people with hydrocephalus can lead active and fulfilling lives.

A type of meningitis caused by the fungus Cryptococcus neoformans, which can be found in soil and decaying organic matter. The fungus is more common in areas with warm climates and poor air quality. It can cause a variety of symptoms including fever, headache, stiff neck, nausea, vomiting, and mental confusion.

It is most commonly seen in people who have compromised immune systems (such as those with HIV/AIDS or taking immunosuppressive medications), and the elderly. It can be diagnosed by analyzing a sample of cerebrospinal fluid (CSF) for the presence of the fungus or its antigens, or through imaging studies such as CT or MRI scans. Treatment typically involves antifungal medications and supportive care to manage symptoms.

Leukemic infiltration refers to the abnormal growth and spread of cancer cells (leukemia) into normal tissues, organs, or bones. It is a common feature of many types of leukemia, including acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and acute lymphoblastic leukemia (ALL).

Leukemic infiltration can cause a range of symptoms, including pain, swelling, and difficulty with movement or function. In severe cases, it can also lead to life-threatening complications such as organ failure or sepsis.

The diagnosis of leukemic infiltration typically involves a combination of physical examination, medical history, laboratory tests (such as blood and bone marrow studies), and imaging studies (such as X-rays, CT scans, or PET scans). Treatment options for leukemic infiltration depend on the specific type of leukemia and the severity of the infiltration, but may include chemotherapy, radiation therapy, immunotherapy, or bone marrow transplantation.

Overall, leukemic infiltration is a serious condition that can have significant impacts on quality of life and survival. Early detection and prompt treatment are important for achieving the best possible outcomes.

The term "leukoencephalopathy" refers to any disease or condition that affects the white matter of the brain, which is composed of nerve fibers covered in a fatty insulating substance called myelin. In LEPM, this degeneration occurs in multiple areas of the brain and spinal cord, leading to a multifocal pattern of damage.

The symptoms of LEPM usually become apparent in early childhood and may include:

* Vision loss or blurred vision
* Seizures
* Difficulty with movement and balance
* Cognitive decline
* Speech difficulties

As the disease progresses, patients may experience increasing disability and loss of motor function, leading to difficulties with walking, speaking, and performing everyday activities. The exact progression of LEPM is highly variable, and some individuals may experience more rapid decline than others.

The cause of LEPM is a genetic mutation in the PLP1 gene, which codes for a protein called proteolipid protein (PLP). This protein plays a critical role in the maintenance of myelin sheaths around nerve fibers, and mutations in the PLP1 gene lead to degeneration of these sheaths and the loss of axons.

There is currently no cure for LEPM, and treatment is focused on managing symptoms and slowing disease progression. This may include medications to control seizures, physical therapy to maintain muscle strength and flexibility, and vision aids to improve visual function. In some cases, bone marrow transplantation may be considered as a potential treatment option.

Overall, LEPM is a severe and debilitating disorder that can significantly impact the quality of life of affected individuals and their families. While there is currently no cure, ongoing research into the genetics and pathophysiology of this disease may lead to new treatment options in the future.

Some common types of cerebellar diseases include:

1. Cerebellar atrophy: This is a condition where the cerebellum shrinks or degenerates, leading to symptoms such as tremors, muscle weakness, and difficulty with movement.
2. Cerebellar degeneration: This is a condition where the cerebellum deteriorates over time, leading to symptoms such as loss of coordination, balance problems, and difficulties with speech and language.
3. Cerebellar tumors: These are abnormal growths that develop in the cerebellum, which can cause a variety of symptoms depending on their size and location.
4. Cerebellar stroke: This is a condition where blood flow to the cerebellum is interrupted, leading to damage to the brain tissue and symptoms such as weakness or paralysis of certain muscle groups.
5. Cerebellar vasculature disorders: These are conditions that affect the blood vessels in the cerebellum, leading to symptoms such as transient ischemic attacks (TIAs) or strokes.
6. Inflammatory diseases: These are conditions that cause inflammation in the cerebellum, leading to symptoms such as tremors, ataxia, and weakness.
7. Infections: Bacterial, viral, or fungal infections can affect the cerebellum and cause a range of symptoms.
8. Trauma: Head injuries or other forms of trauma can damage the cerebellum and lead to symptoms such as loss of coordination, balance problems, and memory loss.
9. Genetic disorders: Certain genetic mutations can affect the development and function of the cerebellum, leading to a range of symptoms.
10. Degenerative diseases: Conditions such as multiple sclerosis, Parkinson's disease, and Huntington's disease can cause degeneration of the cerebellum and lead to symptoms such as tremors, ataxia, and weakness.

It's important to note that this is not an exhaustive list, and there may be other causes of cerebellar symptoms not included here. A healthcare professional can help determine the underlying cause of your symptoms based on a thorough medical history and examination.

1. Meningitis: Inflammation of the membranes surrounding the brain and spinal cord.
2. Encephalitis: Inflammation of the brain tissue.
3. Cranial neuritis: Inflammation of the nerves in the head.
4. Radiculoneuritis: Inflammation of the nerves in the spine.
5. Peripheral neuropathy: Damage to the nerves outside of the CNS.

Lyme neuroborreliosis can be difficult to diagnose, as it may mimic other conditions such as multiple sclerosis or Bell's palsy. Diagnosis is typically based on a combination of clinical evaluation, laboratory tests, and imaging studies. Treatment usually involves antibiotics, and early recognition and intervention are important to prevent long-term neurological damage.

Symptoms of Lyme neuroborreliosis can vary depending on the stage of the disease and the severity of the infection. They may include:

1. Fever, headache, and neck stiffness
2. Confusion, seizures, or loss of consciousness
3. Weakness, numbness, or paralysis in the limbs
4. Pain or tingling sensations in the arms and legs
5. Difficulty with speech, vision, or hearing
6. Incoordination or difficulty walking
7. Balance problems or dizziness
8. Memory loss or difficulty concentrating
9. Mood changes, such as depression or anxiety
10. Sleep disturbances

It is important to note that some people may experience long-term neurological symptoms after treatment for Lyme disease, known as post-treatment Lyme disease syndrome (PTLDS). This condition is not well understood and may be due to a variety of factors, including persistent infection, autoimmune responses, or inflammation.

The diagnosis of Lyme neuroborreliosis can be challenging, as the symptoms can be similar to those of other conditions such as meningitis or encephalitis. Laboratory tests may include blood tests to detect antibodies against the bacteria, as well as spinal fluid testing to rule out other conditions. Imaging studies such as CT or MRI scans may also be used to support the diagnosis.

Treatment of Lyme neuroborreliosis typically involves antibiotics, which can help to clear the infection and alleviate symptoms. In severe cases, hospitalization may be necessary to manage complications such as seizures or muscle weakness. Early recognition and treatment are important to prevent long-term neurological damage.

Prevention is key to avoiding Lyme neuroborreliosis, and this involves protecting against tick bites. Some ways to do this include:

1. Wearing protective clothing such as long sleeves and pants when outdoors in tick-prone areas
2. Using insect repellents that contain DEET or picaridin on exposed skin and clothing
3. Conducting regular tick checks on oneself, children, and pets after spending time outdoors
4. Avoiding areas with high grass and leaf litter, where ticks are more likely to be found
5. Using permethrin-treated clothing and gear to reduce the risk of tick bites.

Overall, Lyme neuroborreliosis is a serious condition that can have long-lasting effects on the nervous system if left untreated. Early recognition and treatment are crucial to preventing complications and improving outcomes for patients with this condition.

Neuroblastoma is caused by a genetic mutation that affects the development and growth of nerve cells. The cancerous cells are often sensitive to chemotherapy, but they can be difficult to remove surgically because they are deeply embedded in the nervous system.

There are several different types of neuroblastoma, including:

1. Infantile neuroblastoma: This type of neuroblastoma occurs in children under the age of one and is often more aggressive than other types of the cancer.
2. Juvenile neuroblastoma: This type of neuroblastoma occurs in children between the ages of one and five and tends to be less aggressive than infantile neuroblastoma.
3. Adult neuroblastoma: This type of neuroblastoma occurs in adults and is rare.
4. Metastatic neuroblastoma: This type of neuroblastoma has spread to other parts of the body, such as the bones or liver.

Symptoms of neuroblastoma can vary depending on the location and size of the tumor, but they may include:

* Abdominal pain
* Fever
* Loss of appetite
* Weight loss
* Fatigue
* Bone pain
* Swelling in the abdomen or neck
* Constipation
* Increased heart rate

Diagnosis of neuroblastoma typically involves a combination of imaging tests, such as CT scans and MRI scans, and biopsies to confirm the presence of cancerous cells. Treatment for neuroblastoma usually involves a combination of chemotherapy, surgery, and radiation therapy. The prognosis for neuroblastoma varies depending on the type of cancer, the age of the child, and the stage of the disease. In general, the younger the child and the more aggressive the treatment, the better the prognosis.

Glioblastomas are highly malignant tumors that can grow rapidly and infiltrate surrounding brain tissue, making them difficult to remove surgically. They often recur after treatment and are usually fatal within a few years of diagnosis.

The symptoms of glioblastoma can vary depending on the location and size of the tumor but may include headaches, seizures, weakness or numbness in the arms or legs, and changes in personality, memory or cognitive function.

Glioblastomas are diagnosed through a combination of imaging tests such as CT or MRI scans, and a biopsy to confirm the presence of cancerous cells. Treatment typically involves surgery to remove as much of the tumor as possible, followed by radiation therapy and chemotherapy to slow the growth of any remaining cancerous cells.

Prognosis for glioblastoma is generally poor, with a five-year survival rate of around 5% for newly diagnosed patients. However, the prognosis can vary depending on factors such as the location and size of the tumor, the patient's age and overall health, and the effectiveness of treatment.

There are several types of ataxia, each with different symptoms and causes. Some common forms of ataxia include:

1. Spinocerebellar ataxia (SCA): This is the most common form of ataxia and is caused by a degeneration of the cerebellum and spinal cord. It can cause progressive weakness, loss of coordination, and difficulty with speaking and swallowing.
2. Friedreich's ataxia: This is the second most common form of ataxia and is caused by a deficiency of vitamin E in the body. It can cause weakness in the legs, difficulty walking, and problems with speech and language.
3. Ataxia-telangiectasia (AT): This is a rare form of ataxia that is caused by a gene mutation. It can cause progressive weakness, loss of coordination, and an increased risk of developing cancer.
4. Acute cerebellar ataxia: This is a sudden and temporary form of ataxia that can be caused by a variety of factors such as infections, injuries, or certain medications.
5. Drug-induced ataxia: Certain medications can cause ataxia as a side effect.
6. Vitamin deficiency ataxia: Deficiencies in vitamins such as vitamin B12 or folate can cause ataxia.
7. Metabolic disorders: Certain metabolic disorders such as hypothyroidism, hyperthyroidism, and hypoglycemia can cause ataxia.
8. Stroke or brain injury: Ataxia can be a result of a stroke or brain injury.
9. Multiple system atrophy (MSA): This is a rare progressive neurodegenerative disorder that can cause ataxia, parkinsonism, and autonomic dysfunction.
10. Spinocerebellar ataxia (SCA): This is a group of rare genetic disorders that can cause progressive cerebellar ataxia, muscle wasting, and other signs and symptoms.

It's important to note that this is not an exhaustive list and there may be other causes of ataxia not mentioned here. If you suspect you or someone you know may have ataxia, it is important to consult a healthcare professional for proper diagnosis and treatment.

The symptoms of cryptococcosis vary depending on the location and severity of the infection. In lung infections, patients may experience fever, cough, chest pain, and difficulty breathing. In CNS infections, patients may experience headaches, confusion, seizures, and loss of coordination. Skin infections can cause skin lesions, and eye infections can cause vision problems.

Cryptococcosis is diagnosed by culturing the fungus from body fluids or tissue samples. Treatment typically involves antifungal medications, such as amphotericin B or fluconazole, which may be given intravenously or orally, depending on the severity and location of the infection. In severe cases, surgery may be required to remove infected tissue or repair damaged organs.

Preventive measures for cryptococcosis include avoiding exposure to fungal spores, practicing good hygiene, and maintaining a healthy immune system. For individuals with HIV/AIDS, antiretroviral therapy can help reduce the risk of developing cryptococcosis.

Overall, while rare, cryptococcosis is a serious opportunistic infection that can affect individuals with compromised immune systems. Early diagnosis and prompt treatment are essential to prevent complications and improve outcomes.

The common types of reoviridae infections include:

1. Rotavirus infection: This is the most common cause of diarrhea in children under five years old worldwide. It can lead to dehydration, hospitalization, and even death in severe cases.
2. Calicivirus infection: This virus is responsible for norovirus, which is the leading cause of gastroenteritis outbreaks in the United States and other countries. It can cause symptoms such as diarrhea, vomiting, and stomach cramps.
3. Aichivirus infection: This virus was first identified in 2013 and has been linked to outbreaks of gastroenteritis in the United States and Europe. The symptoms of this infection are similar to those caused by norovirus.
4. Cysticercosis: This is a parasitic infection that occurs when the larvae of the pork tapeworm (Taenia solium) infect the human brain, eyes, or muscles. It can cause symptoms such as seizures, headaches, and vision problems.
5. Orbivirus infection: This virus is responsible for diseases such as bluetongue and epizootic hemorrhagic fever, which affects animals such as sheep, goats, and cattle. It can also be transmitted to humans through the bite of an infected midge insect.

Reoviridae infections are usually diagnosed based on symptoms, medical history, and laboratory tests such as PCR (polymerase chain reaction) or ELISA (enzyme-linked immunosorbent assay). Treatment of these infections depends on the specific type of virus and the severity of the symptoms.

Prevention measures for Reoviridae infections include good hygiene practices such as washing hands regularly, cooking food thoroughly, and avoiding close contact with people who are sick. Vaccines are also available for some types of Reoviridae infections, such as the rotavirus vaccine that is given to infants to protect against gastroenteritis.

Pre-B ALL is characterized by the abnormal growth of immature white blood cells called B lymphocytes. These cells are produced in the bone marrow and are normally present in the blood. In Pre-B ALL, the abnormal B cells accumulate in the bone marrow, blood, and other organs, crowding out normal cells and causing a variety of symptoms.

The symptoms of Pre-B ALL can vary depending on the individual patient, but may include:

* Fatigue
* Easy bruising or bleeding
* Frequent infections
* Swollen lymph nodes
* Enlarged liver or spleen
* Bone pain
* Headaches
* Confusion or seizures (in severe cases)

Pre-B ALL is most commonly diagnosed in children, but it can also occur in adults. Treatment typically involves a combination of chemotherapy and sometimes bone marrow transplantation. The prognosis for Pre-B ALL is generally good, especially in children, with a high survival rate if treated promptly and effectively. However, the cancer can be more difficult to treat in adults, and the prognosis may be less favorable.

Overall, Pre-B ALL is a rare and aggressive form of leukemia that requires prompt and specialized treatment to improve outcomes for patients.

The exact cause of NMO is not known, but it is believed to be an autoimmune disorder, meaning that the immune system mistakenly attacks healthy cells in the body. Genetic and environmental factors may contribute to the development of NMO. The disease is more common in women than men, and typically affects people between the ages of 20 and 50.

The symptoms of NMO can vary widely depending on the location and severity of the inflammation. Common symptoms include:

* Vision loss or blurred vision
* Pain or numbness in the eyes, face, or neck
* Weakness or paralysis of the limbs
* Difficulty walking or maintaining balance
* Bladder or bowel dysfunction
* Fatigue and fever

NMO can be difficult to diagnose, as the symptoms are similar to those of other conditions such as multiple sclerosis. A diagnosis of NMO is typically made based on a combination of clinical findings, laboratory tests, and imaging studies such as MRI or CT scans.

Treatment for NMO typically involves immunosuppressive medications to reduce inflammation and prevent future attacks. In some cases, corticosteroids may be prescribed to reduce swelling in the central nervous system. Plasmapheresis, a process that removes harmful antibodies from the blood, may also be used in some cases. Physical therapy and other supportive measures can help manage the symptoms of NMO and improve quality of life.

Prognosis for NMO varies depending on the severity of the inflammation and the promptness of treatment. In general, early diagnosis and aggressive treatment can lead to a better outcome. However, some individuals with NMO may experience long-term or permanent damage to their optic nerves or other parts of the central nervous system.

There is currently no cure for NMO, but ongoing research is exploring new treatments and therapies that may help improve outcomes for individuals with this condition. With proper treatment and supportive care, many people with NMO are able to manage their symptoms and lead active lives.

Herpes simplex virus 1 (HSV-1) typically causes cold sores or fever blisters that appear on the lips, mouth, or nose. While herpes simplex virus 2 (HSV-2) is responsible for genital herpes which affects the genital area, buttocks, and anal area.

The infection can be spread through direct contact with an infected person's saliva, mucus, or skin, even if there are no visible sores present. Symptoms of herpes simplex may include itching, burning, tingling, redness, and small blisters that burst and ooze fluid.

There is no cure for herpes simplex, but medications can help manage symptoms and shorten the duration of an outbreak. Antiviral drugs such as acyclovir, famciclovir, and valacyclovir are commonly used to treat herpes simplex.

The symptoms of rabies can vary depending on the severity of the infection and the individual's overall health. Early symptoms may include fever, headache, weakness, and fatigue. As the disease progresses, symptoms can become more severe and can include:

* Agitation and confusion
* Seizures and paralysis
* Hydrophobia (fear of water)
* Spasms and twitching
* Increased salivation
* Fever and chills
* Weakness and paralysis of the face, arms, and legs

If left untreated, rabies is almost always fatal. However, prompt medical attention, including the administration of post-exposure prophylaxis (PEP), can prevent the disease from progressing and save the life of an infected person. PEP typically involves a series of injections with rabies immune globulin and a rabies vaccine.

Rabies is a significant public health concern, particularly in developing countries where access to medical care may be limited. According to the World Health Organization (WHO), there are an estimated 55,000-60,000 human deaths from rabies each year, mostly in Asia and Africa. In the United States, rabies is relatively rare, with only a few cases reported each year. However, it is still important for individuals to be aware of the risks of rabies and take precautions to prevent exposure, such as avoiding contact with wild animals and ensuring that pets are up-to-date on their vaccinations.

The most common form of prion disease in humans is Creutzfeldt-Jakob disease (CJD), which typically affects people over the age of 60. Other forms of prion diseases include variably protease-sensitive prionopathy (VPSPr) and fatal familial insomnia (FFI).

The symptoms of prion diseases vary depending on the specific form of the disease, but they often include:

* Cognitive decline and memory loss
* Coordination and balance problems
* Slurred speech and difficulty with communication
* Difficulty with movement and muscle control
* Depression and anxiety
* Sleep disturbances
* Loss of appetite and weight loss

Prion diseases are diagnosed through a combination of clinical evaluation, imaging studies, and laboratory tests. There is no cure for prion diseases, and treatment is focused on managing symptoms and supporting the patient's quality of life.

Prevention of prion diseases is important, as there is no effective treatment once the disease has developed. Measures to prevent the spread of prion diseases include:

* Implementing strict infection control measures in healthcare settings, such as wearing personal protective equipment and sterilizing equipment and surfaces
* Avoiding exposure to infected tissues and fluids, such as through medical procedures or consumption of contaminated beef products
* Monitoring and testing individuals who have been exposed to prion diseases, such as healthcare workers and family members of affected individuals
* Developing and distributing vaccines and other treatments to prevent and treat prion diseases.

Overall, prion diseases are a group of devastating neurodegenerative disorders that can have a significant impact on the lives of those affected. Understanding the causes, symptoms, diagnosis, treatment, and prevention of these diseases is crucial for improving outcomes and supporting individuals and families affected by prion diseases.

The symptoms of scrapie can vary depending on the age of the animal and the severity of the infection, but they typically include changes in behavior, such as aggression or nervousness, difficulty walking or standing, and weight loss. As the disease progresses, affected animals may also experience seizures, tremors, and paralysis.

Scrapie is a reportable disease, meaning that it must be reported to animal health authorities if it is suspected or confirmed in an animal population. This is because scrapie can be transmitted to humans through the consumption of contaminated animal products, such as meat and milk. While the risk of transmission to humans is low, it is important to take precautions to prevent the spread of the disease.

There is no cure for scrapie, and treatment is limited to managing the symptoms and supporting the affected animal's quality of life. Prevention is key to controlling the spread of scrapie, and this includes vaccination programs, proper disposal of animal carcasses, and strict sanitation practices in animal facilities.

In summary, scrapie is a fatal neurodegenerative disorder that affects sheep, goats, and other animals, caused by an infectious protein called a prion. It is important to report any suspected cases of scrapie to animal health authorities and take precautions to prevent the spread of the disease, as it can be transmitted to humans through contaminated animal products.

The symptoms of Alzheimer's disease can vary from person to person and may progress slowly over time. Early symptoms may include memory loss, confusion, and difficulty with problem-solving. As the disease progresses, individuals may experience language difficulties, visual hallucinations, and changes in mood and behavior.

There is currently no cure for Alzheimer's disease, but there are several medications and therapies that can help manage its symptoms and slow its progression. These include cholinesterase inhibitors, memantine, and non-pharmacological interventions such as cognitive training and behavioral therapy.

Alzheimer's disease is a significant public health concern, affecting an estimated 5.8 million Americans in 2020. It is the sixth leading cause of death in the United States, and its prevalence is expected to continue to increase as the population ages.

There is ongoing research into the causes and potential treatments for Alzheimer's disease, including studies into the role of inflammation, oxidative stress, and the immune system. Other areas of research include the development of biomarkers for early detection and the use of advanced imaging techniques to monitor progression of the disease.

Overall, Alzheimer's disease is a complex and multifactorial disorder that poses significant challenges for individuals, families, and healthcare systems. However, with ongoing research and advances in medical technology, there is hope for improving diagnosis and treatment options in the future.

There are three main forms of poliomyelitis:

1. Non-paralytic polio, which causes symptoms such as fever, headache, and sore throat, but does not lead to paralysis.
2. Paralytic polio, which can cause partial or complete paralysis of the muscles in the limbs, trunk, and respiratory system. This form is more severe and can be fatal.
3. Post-polio syndrome, which occurs in some individuals years after they have recovered from a paralytic polio infection. It is characterized by new muscle weakness, pain, and fatigue.

Poliomyelitis was once a major public health problem worldwide, but widespread immunization campaigns have led to a significant decline in the number of cases. The World Health Organization (WHO) has set a goal of eradicating polio by 2018.

Treatment for poliomyelitis typically focuses on managing symptoms and supporting respiratory function. In severe cases, hospitalization may be necessary to provide intensive care, such as mechanical ventilation. Physical therapy and rehabilitation are also important in helping individuals recover from paralysis.

Prevention is key to controlling the spread of poliomyelitis. This includes vaccination with the oral poliovirus vaccine (OPV), which has been shown to be safe and effective in preventing polio. In addition, good hygiene practices, such as washing hands regularly, can help reduce the risk of transmission.

Some examples of multiple abnormalities include:

1. Multiple chronic conditions: An individual may have multiple chronic conditions such as diabetes, hypertension, arthritis, and heart disease, which can affect their quality of life and increase their risk of complications.
2. Congenital anomalies: Some individuals may be born with multiple physical abnormalities or birth defects, such as heart defects, limb abnormalities, or facial deformities.
3. Mental health disorders: Individuals may experience multiple mental health disorders, such as depression, anxiety, and bipolar disorder, which can impact their cognitive functioning and daily life.
4. Neurological conditions: Some individuals may have multiple neurological conditions, such as epilepsy, Parkinson's disease, and stroke, which can affect their cognitive and physical functioning.
5. Genetic disorders: Individuals with genetic disorders, such as Down syndrome or Turner syndrome, may experience a range of physical and developmental abnormalities.

The term "multiple abnormalities" is often used in medical research and clinical practice to describe individuals who have complex health needs and require comprehensive care. It is important for healthcare providers to recognize and address the multiple needs of these individuals to improve their overall health outcomes.

Peripheral nervous system neoplasms can arise in various parts of the PNS, including:

1. Nerve sheath (Schwann cells): These tumors are called schwannomas or neurilemmomas.
2. Perineural tissue (perineurial cells): These tumors are called perineuriomas.
3. Nerve fibers (neurons): These tumors are called neurofibromas or nerve sheath tumors.
4. Miscellaneous (other types of cells): These tumors are called miscellaneous peripheral nervous system neoplasms.

Some common symptoms of peripheral nervous system neoplasms include:

* Painless lumps or masses in the neck, arm, or leg
* Weakness or numbness in the affected limb
* Tingling or burning sensations in the affected area
* Difficulty with coordination and balance
* Problems with vision or hearing

Peripheral nervous system neoplasms can be diagnosed through a variety of tests, including:

1. Imaging studies (MRI, CT scan, PET scan) to visualize the tumor and determine its location and size.
2. Biopsy to collect a tissue sample for further examination under a microscope.
3. Electromyography (EMG) to test the function of the nerves and muscles.
4. Genetic testing to look for specific genetic changes that may be associated with the tumor.

Treatment options for peripheral nervous system neoplasms depend on the type, size, location, and aggressiveness of the tumor, as well as the patient's overall health and preferences. Some common treatment options include:

1. Surgery to remove the tumor and any affected tissue.
2. Radiation therapy to kill cancer cells and shrink the tumor.
3. Chemotherapy to destroy cancer cells throughout the body.
4. Targeted therapy to specifically target cancer cells with drugs or other substances.
5. Observation and monitoring, as some peripheral nervous system neoplasms may be slow-growing and may not require immediate treatment.

It's important for individuals to seek medical attention if they experience any symptoms that may indicate a peripheral nervous system neoplasm. Early diagnosis and treatment can improve outcomes and increase the chances of successful treatment.

DLBCL is characterized by the rapid growth of malignant B cells in the lymph nodes, spleen, bone marrow, and other organs. These cells can also spread to other parts of the body through the bloodstream or lymphatic system. The disease is often aggressive and can progress quickly without treatment.

The symptoms of DLBCL vary depending on the location and extent of the disease, but they may include:

* Swollen lymph nodes in the neck, underarm, or groin
* Fever
* Fatigue
* Night sweats
* Weight loss
* Abdominal pain or discomfort
* Itching

The diagnosis of DLBCL is based on a combination of physical examination findings, imaging studies (such as CT scans or PET scans), and biopsy results. Treatment typically involves a combination of chemotherapy, radiation therapy, and in some cases, immunotherapy or targeted therapy. The prognosis for DLBCL has improved significantly over the past few decades, with overall survival rates ranging from 60% to 80%, depending on the stage and other factors.

The symptoms of Togaviridae infections can vary depending on the specific virus and the individual infected, but may include fever, headache, joint pain, muscle pain, and rash. In severe cases, these infections can lead to hemorrhagic fever, shock, and even death.

There is no specific treatment for Togaviridae infections, but early diagnosis and supportive care, such as fluid replacement and management of fever and pain, can help alleviate symptoms and improve outcomes. Prevention measures include avoiding mosquito bites by using insect repellents, wearing protective clothing, and staying in air-conditioned or screened areas. Vaccines are also available for some of the diseases caused by Togaviridae viruses, such as yellow fever.

Togaviridae infections are a significant public health concern in many parts of the world, particularly in tropical and subtropical regions where mosquitoes are more prevalent. Outbreaks of these diseases can have a significant impact on individuals, communities, and economies, highlighting the importance of continued research and development of effective prevention and control measures.

The symptoms of VHL disease can vary widely depending on the location and size of the tumors that develop. They may include:

* Tumors in the retina, leading to vision loss or blindness
* Tumors in the brain, leading to seizures, headaches, and neurological problems
* Tumors in the spinal cord, leading to back pain, weakness, and paralysis
* Tumors in the kidneys, leading to high blood pressure, proteinuria, and hematuria (blood in the urine)
* Tumors in the pancreas, leading to diabetes and other endocrine problems
* Tumors in the adrenal glands, leading to hormonal imbalances and adrenal insufficiency

The diagnosis of VHL disease is based on a combination of clinical findings, laboratory tests, and genetic analysis. Imaging studies such as CT or MRI scans may be used to visualize the tumors, and genetic testing can confirm the presence of a VHL gene mutation.

There is no cure for VHL disease, but various treatments can help manage the symptoms and prevent complications. These may include:

* Surgery to remove tumors in the retina, brain, spinal cord, kidneys, pancreas, or adrenal glands
* Chemotherapy to treat malignant tumors
* Radiation therapy to shrink tumors and relieve symptoms
* Medications to control seizures, high blood pressure, diabetes, and hormonal imbalances
* Regular monitoring and follow-up to detect and manage any new or recurring tumors.

The prognosis for VHL disease varies depending on the location and type of tumors, as well as the presence of other health problems. In general, the earlier the diagnosis and treatment, the better the prognosis. With current treatments, many people with VHL disease can lead active and productive lives, but they require ongoing medical care and monitoring to manage their condition.

Examples of syndromes include:

1. Down syndrome: A genetic disorder caused by an extra copy of chromosome 21 that affects intellectual and physical development.
2. Turner syndrome: A genetic disorder caused by a missing or partially deleted X chromosome that affects physical growth and development in females.
3. Marfan syndrome: A genetic disorder affecting the body's connective tissue, causing tall stature, long limbs, and cardiovascular problems.
4. Alzheimer's disease: A neurodegenerative disorder characterized by memory loss, confusion, and changes in personality and behavior.
5. Parkinson's disease: A neurological disorder characterized by tremors, rigidity, and difficulty with movement.
6. Klinefelter syndrome: A genetic disorder caused by an extra X chromosome in males, leading to infertility and other physical characteristics.
7. Williams syndrome: A rare genetic disorder caused by a deletion of genetic material on chromosome 7, characterized by cardiovascular problems, developmental delays, and a distinctive facial appearance.
8. Fragile X syndrome: The most common form of inherited intellectual disability, caused by an expansion of a specific gene on the X chromosome.
9. Prader-Willi syndrome: A genetic disorder caused by a defect in the hypothalamus, leading to problems with appetite regulation and obesity.
10. Sjogren's syndrome: An autoimmune disorder that affects the glands that produce tears and saliva, causing dry eyes and mouth.

Syndromes can be diagnosed through a combination of physical examination, medical history, laboratory tests, and imaging studies. Treatment for a syndrome depends on the underlying cause and the specific symptoms and signs presented by the patient.

Treatment involves administration of anti-TB drugs, usually in combination with supportive care to manage symptoms and prevent complications such as seizures and brain damage. Treatment can take several months and must be completed even if symptoms improve before finishing treatment.

Prevention is difficult because TB bacteria are often resistant to standard antibiotics, so it's important for individuals with HIV or other conditions that weaken the immune system to avoid exposure to TB bacteria whenever possible and receive regular screening tests.

There are many different types of epilepsy, each with its own unique set of symptoms and characteristics. Some common forms of epilepsy include:

1. Generalized Epilepsy: This type of epilepsy affects both sides of the brain and can cause a range of seizure types, including absence seizures, tonic-clonic seizures, and atypical absence seizures.
2. Focal Epilepsy: This type of epilepsy affects only one part of the brain and can cause seizures that are localized to that area. There are several subtypes of focal epilepsy, including partial seizures with complex symptoms and simple partial seizures.
3. Tonic-Clonic Epilepsy: This type of epilepsy is also known as grand mal seizures and can cause a loss of consciousness, convulsions, and muscle stiffness.
4. Lennox-Gastaut Syndrome: This is a rare and severe form of epilepsy that typically develops in early childhood and can cause multiple types of seizures, including tonic, atonic, and myoclonic seizures.
5. Dravet Syndrome: This is a rare genetic form of epilepsy that typically develops in infancy and can cause severe, frequent seizures.
6. Rubinstein-Taybi Syndrome: This is a rare genetic disorder that can cause intellectual disability, developmental delays, and various types of seizures.
7. Other forms of epilepsy include Absence Epilepsy, Myoclonic Epilepsy, and Atonic Epilepsy.

The symptoms of epilepsy can vary widely depending on the type of seizure disorder and the individual affected. Some common symptoms of epilepsy include:

1. Seizures: This is the most obvious symptom of epilepsy and can range from mild to severe.
2. Loss of consciousness: Some people with epilepsy may experience a loss of consciousness during a seizure, while others may remain aware of their surroundings.
3. Confusion and disorientation: After a seizure, some people with epilepsy may feel confused and disoriented.
4. Memory loss: Seizures can cause short-term or long-term memory loss.
5. Fatigue: Epilepsy can cause extreme fatigue, both during and after a seizure.
6. Emotional changes: Some people with epilepsy may experience emotional changes, such as anxiety, depression, or mood swings.
7. Cognitive changes: Epilepsy can affect cognitive function, including attention, memory, and learning.
8. Sleep disturbances: Some people with epilepsy may experience sleep disturbances, such as insomnia or sleepiness.
9. Physical symptoms: Depending on the type of seizure, people with epilepsy may experience physical symptoms such as muscle weakness, numbness or tingling, and sensory changes.
10. Social isolation: Epilepsy can cause social isolation due to fear of having a seizure in public or stigma associated with the condition.

It's important to note that not everyone with epilepsy will experience all of these symptoms, and some people may have different symptoms depending on the type of seizure they experience. Additionally, some people with epilepsy may experience additional symptoms not listed here.

The process of Wallerian degeneration begins with the loss of myelin sheaths that surround the axons and are essential for their proper functioning. As a result of this degeneration, the axoplasm (the cytoplasmic contents of an axon) is exposed to the extracellular space, leading to a series of degradative changes within the axon. These changes include:

1. Breakdown of organelles and their membranes
2. Release of cellular contents into the extracellular space
3. Activation of proteolytic enzymes that degrade axonal structures
4. Influx of ionic fluids and water into the axon, leading to swelling and eventually rupture of the axon.

The onset and progression of Wallerian degeneration depend on various factors, including the severity of the initial injury, the age of the individual, and the presence of any underlying medical conditions. The degenerative process can be slowed down or even halted by various interventions, such as local application of neurotrophic factors or axonal regeneration promoters.

Wallerian degeneration is a common phenomenon in many neurodegenerative diseases and injuries, including traumatic brain injury, multiple sclerosis, and peripheral nerve damage. Understanding the mechanisms of Wallerian degeneration can provide valuable insights into the pathogenesis of these conditions and may lead to the development of novel therapeutic strategies for their management.

Aseptic meningitis can cause a range of symptoms, including headache, fever, stiff neck, nausea and vomiting, sensitivity to light, and confusion. In severe cases, it can lead to brain damage, seizures, and even death.

Aseptic meningitis is diagnosed through a combination of physical examination, medical history, laboratory tests (such as blood cultures and cerebrospinal fluid analysis), and imaging studies (such as CT or MRI scans). Treatment typically involves supportive care, such as intravenous fluids and pain management, as well as addressing any underlying causes. In some cases, antibiotics may be prescribed if a bacterial infection is suspected.

Aseptic meningitis can affect anyone, but it is more common in certain groups, such as children under the age of 5 and people with weakened immune systems. It is important to seek medical attention immediately if symptoms persist or worsen over time.

Recurrence can also refer to the re-emergence of symptoms in a previously treated condition, such as a chronic pain condition that returns after a period of remission.

In medical research, recurrence is often studied to understand the underlying causes of disease progression and to develop new treatments and interventions to prevent or delay its return.

Examples of acute diseases include:

1. Common cold and flu
2. Pneumonia and bronchitis
3. Appendicitis and other abdominal emergencies
4. Heart attacks and strokes
5. Asthma attacks and allergic reactions
6. Skin infections and cellulitis
7. Urinary tract infections
8. Sinusitis and meningitis
9. Gastroenteritis and food poisoning
10. Sprains, strains, and fractures.

Acute diseases can be treated effectively with antibiotics, medications, or other therapies. However, if left untreated, they can lead to chronic conditions or complications that may require long-term care. Therefore, it is important to seek medical attention promptly if symptoms persist or worsen over time.

The symptoms of oligodendroglioma can vary depending on the location and size of the tumor, but may include headaches, seizures, weakness or numbness in the arms or legs, and changes in personality or behavior.

Oligodendrogliomas are diagnosed through a combination of imaging tests such as MRI or CT scans, and tissue biopsy. Treatment options for oligodendroglioma can include surgery to remove the tumor, radiation therapy, and chemotherapy with drugs such as temozolomide.

Prognosis for oligodendroglioma depends on the location, size, and aggressiveness of the tumor, as well as the age and overall health of the patient. In general, benign oligodendrogliomas have a good prognosis, while malignant ones are more difficult to treat and can be associated with a poorer outcome.

There is ongoing research into new treatments for oligodendroglioma, including clinical trials of innovative drugs and therapies.

There are several types of disease susceptibility, including:

1. Genetic predisposition: This refers to the inherent tendency of an individual to develop a particular disease due to their genetic makeup. For example, some families may have a higher risk of developing certain diseases such as cancer or heart disease due to inherited genetic mutations.
2. Environmental susceptibility: This refers to the increased risk of developing a disease due to exposure to environmental factors such as pollutants, toxins, or infectious agents. For example, someone who lives in an area with high levels of air pollution may be more susceptible to developing respiratory problems.
3. Lifestyle susceptibility: This refers to the increased risk of developing a disease due to unhealthy lifestyle choices such as smoking, lack of exercise, or poor diet. For example, someone who smokes and is overweight may be more susceptible to developing heart disease or lung cancer.
4. Immune system susceptibility: This refers to the increased risk of developing a disease due to an impaired immune system. For example, people with autoimmune disorders such as HIV/AIDS or rheumatoid arthritis may be more susceptible to opportunistic infections.

Understanding disease susceptibility can help healthcare providers identify individuals who are at risk of developing certain diseases and provide preventive measures or early intervention to reduce the risk of disease progression. Additionally, genetic testing can help identify individuals with a high risk of developing certain diseases, allowing for earlier diagnosis and treatment.

In summary, disease susceptibility refers to the predisposition of an individual to develop a particular disease or condition due to various factors such as genetics, environment, lifestyle choices, and immune system function. Understanding disease susceptibility can help healthcare providers identify individuals at risk and provide appropriate preventive measures or early intervention to reduce the risk of disease progression.

During relapses, new symptoms may appear or existing ones may worsen, such as vision problems, muscle weakness, coordination and balance difficulties, and cognitive impairment. The immune system mistakenly attacks the protective covering of nerve fibers, leading to communication problems between the brain and the rest of the body.

During remissions, the inflammation and symptoms may subside, but the disease is still active, and some residual disability may persist. RRMS is the most common form of MS, accounting for approximately 85% of all cases.

The symptoms of neuritis can vary depending on the specific nerve affected and the severity of the inflammation. Some common symptoms include:

* Pain along the course of the affected nerve
* Numbness or tingling in the affected area
* Weakness or muscle wasting in the affected muscles
* Difficulty moving or controlling the affected limbs
* Sensory loss or altered sensation in the affected area

Neuritis can affect any nerve in the body, but it is most common in the:

* Peripheral nerves (nerves that connect the brain and spinal cord to the rest of the body)
* Optic nerve (which carries visual information from the eye to the brain)
* Auditory nerve (which carries sound information from the inner ear to the brain)
* Spinal nerves (which run down the spine and carry sensory information to and from the brain)

Treatment of neuritis depends on the underlying cause and the severity of the condition. It may involve medications such as pain relievers, anti-inflammatory drugs, or corticosteroids, as well as physical therapy and lifestyle modifications to manage symptoms and promote healing. In some cases, surgery may be necessary to relieve compression or damage to the affected nerve.

Preventive measures for neuritis include:

* Maintaining a healthy lifestyle, including regular exercise, a balanced diet, and adequate sleep
* Avoiding exposure to toxins or other harmful substances that can damage nerves
* Managing chronic conditions such as diabetes, autoimmune disorders, or infections that can increase the risk of neuritis.

The symptoms of West Nile Fever typically develop within 3-14 days after the bite of an infected mosquito and can range from mild to severe. Mild symptoms may include fever, headache, muscle weakness, and joint pain. Severe symptoms can include high fever, stiff neck, confusion, loss of consciousness, and in rare cases, death.

There is no specific treatment for West Nile Fever, but supportive care such as rest, hydration, and pain relief medications may be provided to help manage the symptoms. The prognosis for most people with West Nile Fever is generally good, but it can be more severe in older adults and those with underlying health conditions.

Prevention of West Nile Fever involves protecting oneself against mosquito bites by using insect repellents, wearing protective clothing, and staying indoors during peak mosquito activity. Eliminating standing water around homes and communities can also help reduce the risk of mosquito breeding and transmission of the virus.

In conclusion, West Nile Fever is a viral disease that is transmitted to humans through the bite of infected mosquitoes, and can cause mild to severe symptoms. Prevention involves protecting oneself against mosquito bites and eliminating standing water to reduce the risk of mosquito breeding and transmission of the virus.

Pseudorabies is characterized by fever, anorexia, lethargy, and a characteristic skin rash on the face, neck, and limbs. In severe cases, the disease can cause inflammation of the central nervous system (CNS), respiratory distress, and death.

The pseudorabies virus is primarily transmitted through close contact with infected animals or their bodily fluids, such as saliva, urine, or feces. The virus can also be spread through contaminated objects, such as needles or surgical instruments, or through the bite of an infected animal.

Pseudorabies is typically diagnosed based on a combination of clinical signs, laboratory tests (such as PCR or ELISA), and serology. There is no specific treatment for the disease, but antiviral medications may be used in severe cases to reduce the severity of symptoms.

In humans, pseudorabies is a rare disease that is typically associated with exposure to infected animals or contaminated objects. The disease is more common in people who work with swine or other animals, such as veterinarians or farmers. In rare cases, pseudorabies has been transmitted through organ transplantation or blood transfusion.

Prevention of pseudorabies primarily involves avoiding contact with infected animals and taking precautions to prevent the spread of the virus. This includes wearing protective clothing and gloves when handling animals, properly disinfecting equipment and surfaces, and ensuring that all animal products are thoroughly cooked before consumption.

In summary, pseudorabies is a viral disease that affects swine and other animals, as well as humans in rare cases. It is caused by the pseudorabies virus and can be transmitted through close contact with infected animals or contaminated objects. While there is no specific treatment for the disease, antiviral medications may be used in severe cases to reduce the severity of symptoms. Prevention primarily involves avoiding contact with infected animals and taking precautions to prevent the spread of the virus.

Disease progression can be classified into several types based on the pattern of worsening:

1. Chronic progressive disease: In this type, the disease worsens steadily over time, with a gradual increase in symptoms and decline in function. Examples include rheumatoid arthritis, osteoarthritis, and Parkinson's disease.
2. Acute progressive disease: This type of disease worsens rapidly over a short period, often followed by periods of stability. Examples include sepsis, acute myocardial infarction (heart attack), and stroke.
3. Cyclical disease: In this type, the disease follows a cycle of worsening and improvement, with periodic exacerbations and remissions. Examples include multiple sclerosis, lupus, and rheumatoid arthritis.
4. Recurrent disease: This type is characterized by episodes of worsening followed by periods of recovery. Examples include migraine headaches, asthma, and appendicitis.
5. Catastrophic disease: In this type, the disease progresses rapidly and unpredictably, with a poor prognosis. Examples include cancer, AIDS, and organ failure.

Disease progression can be influenced by various factors, including:

1. Genetics: Some diseases are inherited and may have a predetermined course of progression.
2. Lifestyle: Factors such as smoking, lack of exercise, and poor diet can contribute to disease progression.
3. Environmental factors: Exposure to toxins, allergens, and other environmental stressors can influence disease progression.
4. Medical treatment: The effectiveness of medical treatment can impact disease progression, either by slowing or halting the disease process or by causing unintended side effects.
5. Co-morbidities: The presence of multiple diseases or conditions can interact and affect each other's progression.

Understanding the type and factors influencing disease progression is essential for developing effective treatment plans and improving patient outcomes.

1. Muscle weakness and twitching
2. Numbness or tingling in the hands and feet
3. Difficulty walking or maintaining balance
4. Memory loss and confusion
5. Slurred speech and difficulty with concentration
6. Mood changes, such as irritability and anxiety
7. Seizures
8. Headaches and tremors.

If you suspect that you have been exposed to mercury or are experiencing symptoms of mercury poisoning, it is important to seek medical attention as soon as possible. A healthcare professional will perform a physical examination and may order laboratory tests to confirm the diagnosis and determine the extent of the damage. Treatment for mercury poisoning typically involves removing the source of exposure and providing supportive care to manage symptoms. In severe cases, chelation therapy may be used to remove excess mercury from the body.

The term "neurocutaneous" refers to the combination of nervous system and cutaneous (skin) manifestations that are present in these disorders. Neurocutaneous syndromes can be caused by a variety of genetic mutations, and they can affect individuals of all ages and backgrounds.

Examples of neurocutaneous syndromes include:

1. Neurofibromatosis type 1 (NF1): This is a common neurocutaneous syndrome that affects about 1 in every 3,000 individuals. It is characterized by the growth of benign tumors on the skin and nervous system symptoms such as seizures, headaches, and learning disabilities.
2. Tuberous sclerosis complex (TSC): This rare neurocutaneous syndrome affects about 1 in every 6,000 individuals and is characterized by the growth of non-cancerous tumors on the skin and organs, as well as seizures, developmental delays, and cognitive impairments.
3. Proteus syndrome: This rare neurocutaneous syndrome affects about 1 in every 25,000 individuals and is characterized by asymmetrical growth of skin and other tissues, as well as developmental delays, intellectual disability, and an increased risk of cancer.
4. Sturge-Weber syndrome: This rare neurocutaneous syndrome affects about 1 in every 20,000 individuals and is characterized by a port-wine stain on the face and seizures, as well as developmental delays, intellectual disability, and glaucoma.

The diagnosis of neurocutaneous syndromes typically involves a combination of clinical examination, imaging studies (such as MRI or CT scans), and genetic testing. Treatment for these conditions varies depending on the specific syndrome and may include medications to control seizures, surgery to remove tumors or repair developmental abnormalities, and other supportive therapies to address cognitive and behavioral issues.

Neurocutaneous syndromes are rare and often result in significant morbidity and mortality. However, with early diagnosis and appropriate treatment, many individuals with these conditions can lead fulfilling lives.

Hemangiomas are caused by an abnormal formation of blood vessels during fetal development. They are more common in infants and children, but they can also occur in adults. The exact cause of CNS hemangiomas is not fully understood, but genetic mutations, environmental factors, and hormonal influences have been implicated.

The symptoms of CNS hemangiomas can vary depending on their location and size. Large hemangiomas can cause pressure on surrounding brain tissue, leading to symptoms such as headaches, seizures, and developmental delays. Smaller hemangiomas may not cause any symptoms at all, but they can still be detected through imaging tests such as MRI or CT scans.

Hemangiomas can occur anywhere in the CNS, but they are most commonly found in the brain, specifically in the cerebral cortex and basal ganglia. They can also occur in the spinal cord, where they can cause symptoms such as pain, numbness, and weakness in the limbs.

The diagnosis of a CNS hemangioma is based on a combination of clinical findings, imaging studies, and histopathological analysis. Imaging studies, such as MRI or CT scans, can help identify the location and size of the hemangioma, while histopathological analysis can confirm the presence of dilated blood vessels.

There is no specific treatment for CNS hemangiomas, but various options are available depending on the severity of the condition and the symptoms it causes. Observation, corticosteroids, and surgery are some of the most common treatments used to manage CNS hemangiomas. In some cases, interventional techniques such as embolization or stereotactic radiosurgery may be necessary to treat the condition.

Overall, CNS hemangiomas are benign vascular tumors that can cause a range of symptoms and cognitive impairments in children and adults. While there is no specific treatment for these tumors, various options are available to manage their symptoms and improve quality of life. It is important to seek medical attention if symptoms persist or worsen over time, as early diagnosis and treatment can significantly improve outcomes.

The burden of chronic diseases is significant, with over 70% of deaths worldwide attributed to them, according to the World Health Organization (WHO). In addition to the physical and emotional toll they take on individuals and their families, chronic diseases also pose a significant economic burden, accounting for a large proportion of healthcare expenditure.

In this article, we will explore the definition and impact of chronic diseases, as well as strategies for managing and living with them. We will also discuss the importance of early detection and prevention, as well as the role of healthcare providers in addressing the needs of individuals with chronic diseases.

What is a Chronic Disease?

A chronic disease is a condition that lasts for an extended period of time, often affecting daily life and activities. Unlike acute diseases, which have a specific beginning and end, chronic diseases are long-term and persistent. Examples of chronic diseases include:

1. Diabetes
2. Heart disease
3. Arthritis
4. Asthma
5. Cancer
6. Chronic obstructive pulmonary disease (COPD)
7. Chronic kidney disease (CKD)
8. Hypertension
9. Osteoporosis
10. Stroke

Impact of Chronic Diseases

The burden of chronic diseases is significant, with over 70% of deaths worldwide attributed to them, according to the WHO. In addition to the physical and emotional toll they take on individuals and their families, chronic diseases also pose a significant economic burden, accounting for a large proportion of healthcare expenditure.

Chronic diseases can also have a significant impact on an individual's quality of life, limiting their ability to participate in activities they enjoy and affecting their relationships with family and friends. Moreover, the financial burden of chronic diseases can lead to poverty and reduce economic productivity, thus having a broader societal impact.

Addressing Chronic Diseases

Given the significant burden of chronic diseases, it is essential that we address them effectively. This requires a multi-faceted approach that includes:

1. Lifestyle modifications: Encouraging healthy behaviors such as regular physical activity, a balanced diet, and smoking cessation can help prevent and manage chronic diseases.
2. Early detection and diagnosis: Identifying risk factors and detecting diseases early can help prevent or delay their progression.
3. Medication management: Effective medication management is crucial for controlling symptoms and slowing disease progression.
4. Multi-disciplinary care: Collaboration between healthcare providers, patients, and families is essential for managing chronic diseases.
5. Health promotion and disease prevention: Educating individuals about the risks of chronic diseases and promoting healthy behaviors can help prevent their onset.
6. Addressing social determinants of health: Social determinants such as poverty, education, and employment can have a significant impact on health outcomes. Addressing these factors is essential for reducing health disparities and improving overall health.
7. Investing in healthcare infrastructure: Investing in healthcare infrastructure, technology, and research is necessary to improve disease detection, diagnosis, and treatment.
8. Encouraging policy change: Policy changes can help create supportive environments for healthy behaviors and reduce the burden of chronic diseases.
9. Increasing public awareness: Raising public awareness about the risks and consequences of chronic diseases can help individuals make informed decisions about their health.
10. Providing support for caregivers: Chronic diseases can have a significant impact on family members and caregivers, so providing them with support is essential for improving overall health outcomes.

Conclusion

Chronic diseases are a major public health burden that affect millions of people worldwide. Addressing these diseases requires a multi-faceted approach that includes lifestyle changes, addressing social determinants of health, investing in healthcare infrastructure, encouraging policy change, increasing public awareness, and providing support for caregivers. By taking a comprehensive approach to chronic disease prevention and management, we can improve the health and well-being of individuals and communities worldwide.

Bunyaviridae infections can be severe and potentially life-threatening, especially in certain populations such as young children, older adults, and people with weakened immune systems. Symptoms of Bunyaviridae infections can include fever, headache, muscle pain, vomiting, diarrhea, and in severe cases, hemorrhagic symptoms such as bleeding from the eyes, ears, or gastrointestinal tract.

There is no specific treatment for Bunyaviridae infections, but supportive care and management of symptoms can help alleviate the severity of the illness. Prevention of Bunyaviridae infections includes avoiding insect bites by using protective clothing and insect repellents, as well as controlling the populations of potential vector insects in affected areas.

Examples of diseases caused by Bunyaviridae viruses include Rift Valley fever, which is common in Africa and the Middle East, and Crimean-Congo hemorrhagic fever, which is found in parts of Europe, Asia, and Africa. Other examples of Bunyaviridae infections include La Crosse encephalitis, which is found in North America, and Japanese encephalitis, which is prevalent in parts of Asia.

It's important to note that Bunyaviridae infections can be challenging to diagnose, as the symptoms can be similar to other viral or bacterial infections. Laboratory testing, such as PCR or ELISA assays, is often necessary to confirm the presence of a Bunyaviridae virus.

Prevention and control measures for Bunyaviridae infections include avoiding insect bites, controlling vector populations, and implementing public health measures such as surveillance, education, and vaccination programs. Research into the development of vaccines and antiviral drugs against Bunyaviridae viruses is ongoing, but there are currently no licensed treatments available for these infections.

Some common types of eye neoplasms include:

1. Uveal melanoma: This is a malignant tumor that develops in the uvea, the middle layer of the eye. It is the most common primary intraocular cancer in adults and can spread to other parts of the body if left untreated.
2. Retinoblastoma: This is a rare type of cancer that affects children and develops in the retina. It is usually diagnosed before the age of 5 and is highly treatable with surgery, chemotherapy, and radiation therapy.
3. Conjunctival melanoma: This is a malignant tumor that develops in the conjunctiva, the thin membrane that covers the white part of the eye. It is more common in older adults and can be treated with surgery and/or radiation therapy.
4. Ocular sarcomas: These are rare types of cancer that develop in the eye tissues, including the retina, optic nerve, and uvea. They can be benign or malignant and may require surgical removal or radiation therapy.
5. Secondary intraocular tumors: These are tumors that metastasize (spread) to the eye from other parts of the body, such as breast cancer or lung cancer.

The symptoms of eye neoplasms can vary depending on their location and type, but may include:

* Blurred vision
* Eye pain or discomfort
* Redness or inflammation in the eye
* Sensitivity to light
* Floaters (specks or cobwebs in vision)
* Flashes of light
* Abnormal pupil size or shape

Early detection and treatment of eye neoplasms are important to preserve vision and prevent complications. Diagnosis is typically made through a combination of physical examination, imaging tests such as ultrasound or MRI, and biopsy (removing a small sample of tissue for examination under a microscope). Treatment options may include:

* Surgery to remove the tumor
* Radiation therapy to kill cancer cells
* Chemotherapy to destroy cancer cells with medication
* Observation and monitoring if the tumor is slow-growing or benign

It's important to seek medical attention if you experience any unusual symptoms in your eye, as early detection and treatment can improve outcomes.

Neurosyphilis can occur at any stage of syphilis, but it is most common in the late stages of the infection. The symptoms of neurosyphilis can be diverse and may include:

1. Meningitis: Inflammation of the membranes that cover the brain and spinal cord (meninges).
2. Encephalitis: Inflammation of the brain tissue.
3. Cranial nerve palsies: Weakness or paralysis of the nerves that control eye movements, facial muscles, and other functions.
4. Seizures: Convulsions or fits can occur in severe cases of neurosyphilis.
5. Dementia: Confusion, memory loss, and personality changes can occur in advanced stages of the infection.
6. Tabes dorsalis: A condition that affects the spinal cord, causing weakness, numbness, and pain in the legs.
7. Papaiacquine: A condition that affects the brain and spinal cord, leading to difficulty with coordination and balance.

Neurosyphilis is diagnosed through a combination of physical examination, laboratory tests, and imaging studies such as CT or MRI scans. Treatment typically involves antibiotics, and early treatment can help prevent long-term complications and improve outcomes.

If left untreated, neurosyphilis can lead to serious long-term complications, including:

1. Meningovascular syphilis: Inflammation of the blood vessels in the meninges can lead to stroke or death.
2. General paresis: Permanent damage to the brain and spinal cord can result in personality changes, cognitive impairment, and loss of coordination and balance.
3. Tabes dorsalis: Permanent damage to the spinal cord can cause weakness, numbness, and pain in the legs, leading to a condition known as "parkinsonism."
4. Late benign syphilis: A condition characterized by progressive loss of vision, blindness, and other neurological symptoms.
5. Cardiovascular syphilis: Inflammation of the heart and blood vessels can lead to heart failure, aortic aneurysms, and other cardiovascular complications.

It is important to seek medical attention if you suspect that you or someone you know may have neurosyphilis, as early treatment can help prevent long-term complications and improve outcomes.

A viral infection that affects the brain and spinal cord, caused by a tick-borne virus. Also called TBEV (Tick-Borne Encephalitis Virus). The symptoms of this condition include fever, headache, muscle weakness, confusion, and difficulty speaking or understanding speech. In severe cases, it can lead to inflammation of the brain, seizures, and even death.

Tick-borne encephalitis is most commonly found in Asia, Europe, and parts of North America. It is transmitted to humans through the bite of infected ticks, typically found in forested areas and grasslands. There is no specific treatment for tick-borne encephalitis, but antiviral medications and supportive care may be given to help manage symptoms. Prevention involves avoiding tick habitats and using protective measures such as insect repellents and clothing coverage when outdoors.

Neurogenic inflammation is often characterized by a heightened immune response, increased production of cytokines, and activation of immune cells such as macrophages and microglia. This condition can lead to a range of symptoms including pain, swelling, redness, and loss of function in the affected area.

Neurogenic inflammation can be difficult to diagnose as it can mimic other conditions such as infection or autoimmune disorders. Treatment options for neurogenic inflammation vary depending on the underlying cause but may include immunosuppressive medications, anti-inflammatory drugs, and therapies aimed at reducing nerve damage and promoting healing.

In summary, neurogenic inflammation is a complex condition that can result from various forms of nervous system damage or injury. It is characterized by an exaggerated immune response, increased production of pro-inflammatory cytokines, and activation of immune cells. Accurate diagnosis and appropriate treatment are essential to prevent further nerve damage and promote healing.

There are several subtypes of NHL, including:

1. B-cell lymphomas (such as diffuse large B-cell lymphoma and follicular lymphoma)
2. T-cell lymphomas (such as peripheral T-cell lymphoma and mycosis fungoides)
3. Natural killer cell lymphomas (such as nasal NK/T-cell lymphoma)
4. Histiocyte-rich B-cell lymphoma
5. Primary mediastinal B-cell lymphoma
6. Mantle cell lymphoma
7. Waldenström macroglobulinemia
8. Lymphoplasmacytoid lymphoma
9. Myelodysplastic syndrome/myeloproliferative neoplasms (MDS/MPN) related lymphoma

These subtypes can be further divided into other categories based on the specific characteristics of the cancer cells.

Symptoms of NHL can vary depending on the location and size of the tumor, but may include:

* Swollen lymph nodes in the neck, underarm, or groin
* Fever
* Fatigue
* Weight loss
* Night sweats
* Itching
* Abdominal pain
* Swollen spleen

Treatment for NHL typically involves a combination of chemotherapy, radiation therapy, and in some cases, targeted therapy or immunotherapy. The specific treatment plan will depend on the subtype of NHL, the stage of the cancer, and other individual factors.

Overall, NHL is a complex and diverse group of cancers that require specialized care from a team of medical professionals, including hematologists, oncologists, radiation therapists, and other support staff. With advances in technology and treatment options, many people with NHL can achieve long-term remission or a cure.

There are several subtypes of lymphoma, B-cell, including:

1. Diffuse large B-cell lymphoma (DLBCL): This is the most common type of B-cell lymphoma and typically affects older adults.
2. Follicular lymphoma: This type of lymphoma grows slowly and often does not require treatment for several years.
3. Marginal zone lymphoma: This type of lymphoma develops in the marginal zone of the spleen or other lymphoid tissues.
4. Hodgkin lymphoma: This is a type of B-cell lymphoma that is characterized by the presence of Reed-Sternberg cells, which are abnormal cells that can be identified under a microscope.

The symptoms of lymphoma, B-cell can vary depending on the subtype and the location of the tumor. Common symptoms include swollen lymph nodes, fatigue, fever, night sweats, and weight loss.

Treatment for lymphoma, B-cell usually involves chemotherapy, which is a type of cancer treatment that uses drugs to kill cancer cells. Radiation therapy may also be used in some cases. In some cases, bone marrow or stem cell transplantation may be recommended.

Prognosis for lymphoma, B-cell depends on the subtype and the stage of the disease at the time of diagnosis. In general, the prognosis is good for patients with early-stage disease, but the cancer can be more difficult to treat if it has spread to other parts of the body.

Prevention of lymphoma, B-cell is not possible, as the exact cause of the disease is not known. However, avoiding exposure to certain risk factors, such as viral infections and pesticides, may help reduce the risk of developing the disease. Early detection and treatment can also improve outcomes for patients with lymphoma, B-cell.

Lymphoma, B-cell is a type of cancer that affects the immune system and can be treated with chemotherapy and other therapies. The prognosis varies depending on the subtype and stage of the disease at diagnosis. Prevention is not possible, but early detection and treatment can improve outcomes for patients with this condition.

Body weight is an important health indicator, as it can affect an individual's risk for certain medical conditions, such as obesity, diabetes, and cardiovascular disease. Maintaining a healthy body weight is essential for overall health and well-being, and there are many ways to do so, including a balanced diet, regular exercise, and other lifestyle changes.

There are several ways to measure body weight, including:

1. Scale: This is the most common method of measuring body weight, and it involves standing on a scale that displays the individual's weight in kg or lb.
2. Body fat calipers: These are used to measure body fat percentage by pinching the skin at specific points on the body.
3. Skinfold measurements: This method involves measuring the thickness of the skin folds at specific points on the body to estimate body fat percentage.
4. Bioelectrical impedance analysis (BIA): This is a non-invasive method that uses electrical impulses to measure body fat percentage.
5. Dual-energy X-ray absorptiometry (DXA): This is a more accurate method of measuring body composition, including bone density and body fat percentage.

It's important to note that body weight can fluctuate throughout the day due to factors such as water retention, so it's best to measure body weight at the same time each day for the most accurate results. Additionally, it's important to use a reliable scale or measuring tool to ensure accurate measurements.

Causes:

* Genetic mutations or deletions
* Infections such as meningitis or encephalitis
* Stroke or bleeding in the brain
* Traumatic head injury
* Multiple sclerosis or other demyelinating diseases
* Brain tumors
* Cerebellar degeneration due to aging

Symptoms:

* Coordination difficulties, such as stumbling or poor balance
* Tremors or shaky movements
* Slurred speech and difficulty with fine motor skills
* Nystagmus (involuntary eye movements)
* Difficulty with gait and walking
* Fatigue, weakness, and muscle wasting

Diagnosis:

* Physical examination and medical history
* Neurological examination to test coordination, balance, and reflexes
* Imaging studies such as MRI or CT scans to rule out other conditions
* Genetic testing to identify inherited forms of cerebellar ataxia
* Electromyography (EMG) to test muscle activity and nerve function

Treatment:

* Physical therapy to improve balance, coordination, and gait
* Occupational therapy to help with daily activities and fine motor skills
* Speech therapy to address slurred speech and communication difficulties
* Medications to manage symptoms such as tremors or spasticity
* Assistive devices such as canes or walkers to improve mobility

Prognosis:

* The prognosis for cerebellar ataxia varies depending on the underlying cause. In some cases, the condition may be slowly progressive and lead to significant disability over time. In other cases, the condition may remain stable or even improve with treatment.

Living with cerebellar ataxia can be challenging, but there are many resources available to help individuals with the condition manage their symptoms and maintain their quality of life. These resources may include:

* Physical therapy to improve balance and coordination
* Occupational therapy to assist with daily activities
* Speech therapy to address communication difficulties
* Assistive devices such as canes or walkers to improve mobility
* Medications to manage symptoms such as tremors or spasticity
* Support groups for individuals with cerebellar ataxia and their families

Overall, the key to managing cerebellar ataxia is early diagnosis and aggressive treatment. With proper management, individuals with this condition can lead active and fulfilling lives despite the challenges they face.

There are two main forms of the disease, depending on the species of parasite and the location where the infection is acquired:

* T. b. rhodesiense infection is found primarily in East and Southern Africa, and is characterized by a more severe form of the disease. Symptoms can include fever, headache, joint pain, and skin rashes, as well as swelling of the lymph nodes and spleen. If left untreated, the disease can progress to a more advanced stage, characterized by neurological symptoms such as confusion, seizures, and coma.
* T. b. gambiense infection is found primarily in West and Central Africa, and is characterized by a milder form of the disease. Symptoms can include fever, joint pain, and skin rashes, as well as swelling of the lymph nodes and spleen.

Both forms of the disease are treatable with antiparasitic drugs, but if left untreated, they can be fatal. Diagnosis is typically made through a combination of physical examination, laboratory tests, and imaging studies such as ultrasound or CT scans. Treatment is usually with melarsoprol or eflornithine, and in some cases, surgery may be necessary to remove affected tissue or organs.

Prevention of trypanosomiasis involves controlling the population of tsetse flies through the use of insecticides, traps, and other methods, as well as educating people about how to avoid being bitten by infected flies. There is also ongoing research into the development of a vaccine against trypanosomiasis.

1. Parvovirus (Parvo): A highly contagious viral disease that affects dogs of all ages and breeds, causing symptoms such as vomiting, diarrhea, and severe dehydration.
2. Distemper: A serious viral disease that can affect dogs of all ages and breeds, causing symptoms such as fever, coughing, and seizures.
3. Rabies: A deadly viral disease that affects dogs and other animals, transmitted through the saliva of infected animals, and causing symptoms such as aggression, confusion, and paralysis.
4. Heartworms: A common condition caused by a parasitic worm that infects the heart and lungs of dogs, leading to symptoms such as coughing, fatigue, and difficulty breathing.
5. Ticks and fleas: These external parasites can cause skin irritation, infection, and disease in dogs, including Lyme disease and tick-borne encephalitis.
6. Canine hip dysplasia (CHD): A genetic condition that affects the hip joint of dogs, causing symptoms such as arthritis, pain, and mobility issues.
7. Osteosarcoma: A type of bone cancer that affects dogs, often diagnosed in older dogs and causing symptoms such as lameness, swelling, and pain.
8. Allergies: Dog allergies can cause skin irritation, ear infections, and other health issues, and may be triggered by environmental factors or specific ingredients in their diet.
9. Gastric dilatation-volvulus (GDV): A life-threatening condition that occurs when a dog's stomach twists and fills with gas, causing symptoms such as vomiting, pain, and difficulty breathing.
10. Cruciate ligament injuries: Common in active dogs, these injuries can cause joint instability, pain, and mobility issues.

It is important to monitor your dog's health regularly and seek veterinary care if you notice any changes or abnormalities in their behavior, appetite, or physical condition.

Neoplasm refers to an abnormal growth of cells that can be benign (non-cancerous) or malignant (cancerous). Neoplasms can occur in any part of the body and can affect various organs and tissues. The term "neoplasm" is often used interchangeably with "tumor," but while all tumors are neoplasms, not all neoplasms are tumors.

Types of Neoplasms

There are many different types of neoplasms, including:

1. Carcinomas: These are malignant tumors that arise in the epithelial cells lining organs and glands. Examples include breast cancer, lung cancer, and colon cancer.
2. Sarcomas: These are malignant tumors that arise in connective tissue, such as bone, cartilage, and fat. Examples include osteosarcoma (bone cancer) and soft tissue sarcoma.
3. Lymphomas: These are cancers of the immune system, specifically affecting the lymph nodes and other lymphoid tissues. Examples include Hodgkin lymphoma and non-Hodgkin lymphoma.
4. Leukemias: These are cancers of the blood and bone marrow that affect the white blood cells. Examples include acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL).
5. Melanomas: These are malignant tumors that arise in the pigment-producing cells called melanocytes. Examples include skin melanoma and eye melanoma.

Causes and Risk Factors of Neoplasms

The exact causes of neoplasms are not fully understood, but there are several known risk factors that can increase the likelihood of developing a neoplasm. These include:

1. Genetic predisposition: Some people may be born with genetic mutations that increase their risk of developing certain types of neoplasms.
2. Environmental factors: Exposure to certain environmental toxins, such as radiation and certain chemicals, can increase the risk of developing a neoplasm.
3. Infection: Some neoplasms are caused by viruses or bacteria. For example, human papillomavirus (HPV) is a common cause of cervical cancer.
4. Lifestyle factors: Factors such as smoking, excessive alcohol consumption, and a poor diet can increase the risk of developing certain types of neoplasms.
5. Family history: A person's risk of developing a neoplasm may be higher if they have a family history of the condition.

Signs and Symptoms of Neoplasms

The signs and symptoms of neoplasms can vary depending on the type of cancer and where it is located in the body. Some common signs and symptoms include:

1. Unusual lumps or swelling
2. Pain
3. Fatigue
4. Weight loss
5. Change in bowel or bladder habits
6. Unexplained bleeding
7. Coughing up blood
8. Hoarseness or a persistent cough
9. Changes in appetite or digestion
10. Skin changes, such as a new mole or a change in the size or color of an existing mole.

Diagnosis and Treatment of Neoplasms

The diagnosis of a neoplasm usually involves a combination of physical examination, imaging tests (such as X-rays, CT scans, or MRI scans), and biopsy. A biopsy involves removing a small sample of tissue from the suspected tumor and examining it under a microscope for cancer cells.

The treatment of neoplasms depends on the type, size, location, and stage of the cancer, as well as the patient's overall health. Some common treatments include:

1. Surgery: Removing the tumor and surrounding tissue can be an effective way to treat many types of cancer.
2. Chemotherapy: Using drugs to kill cancer cells can be effective for some types of cancer, especially if the cancer has spread to other parts of the body.
3. Radiation therapy: Using high-energy radiation to kill cancer cells can be effective for some types of cancer, especially if the cancer is located in a specific area of the body.
4. Immunotherapy: Boosting the body's immune system to fight cancer can be an effective treatment for some types of cancer.
5. Targeted therapy: Using drugs or other substances to target specific molecules on cancer cells can be an effective treatment for some types of cancer.

Prevention of Neoplasms

While it is not always possible to prevent neoplasms, there are several steps that can reduce the risk of developing cancer. These include:

1. Avoiding exposure to known carcinogens (such as tobacco smoke and radiation)
2. Maintaining a healthy diet and lifestyle
3. Getting regular exercise
4. Not smoking or using tobacco products
5. Limiting alcohol consumption
6. Getting vaccinated against certain viruses that are associated with cancer (such as human papillomavirus, or HPV)
7. Participating in screening programs for early detection of cancer (such as mammograms for breast cancer and colonoscopies for colon cancer)
8. Avoiding excessive exposure to sunlight and using protective measures such as sunscreen and hats to prevent skin cancer.

It's important to note that not all cancers can be prevented, and some may be caused by factors that are not yet understood or cannot be controlled. However, by taking these steps, individuals can reduce their risk of developing cancer and improve their overall health and well-being.

Peripheral neuroectodermal tumors are those that occur outside of the CNS, typically in the peripheral nervous system (PNS). Examples of peripheral neuroectodermal tumors include:

1. Neuroblastoma: a type of cancer that develops in nerve tissue outside of the brain and spinal cord.
2. Ganglioneuroma: a rare type of tumor that occurs in the peripheral nervous system, typically in the abdomen or extremities.
3. Plexiform neuroectodermal tumor: a rare type of tumor that occurs in the peripheral nervous system, typically in the limbs.
4. Malignant peripheral nerve sheath tumors (MPNST): a type of cancer that develops in the covering of nerves outside of the CNS.

These tumors are rare and can be difficult to diagnose and treat. They often have a poor prognosis, but with early detection and appropriate treatment, outcomes can improve. Treatment options may include surgery, chemotherapy, and radiation therapy.

The exact cause of paraneoplastic syndromes is not fully understood, but it is believed that the immune system mistakenly attacks healthy cells in the nervous system, leading to damage and dysfunction. Some research suggests that certain types of cancer may trigger an autoimmune response, while other factors such as genetics or environmental exposures may also play a role.

Paraneoplastic syndromes can be difficult to diagnose, as they often present with symptoms that are similar to those of more common conditions such as multiple sclerosis or stroke. However, certain tests such as electromyography (EMG) and nerve conduction studies (NCS) can help rule out other conditions and confirm the presence of a paraneoplastic syndrome.

Treatment for paraneoplastic syndromes typically focuses on managing symptoms and addressing any underlying cancer that may be present. Medications such as corticosteroids, immunosuppressive drugs, and chemotherapy may be used to reduce inflammation and suppress the immune system, while surgery or radiation therapy may be necessary to remove cancerous tissue. In some cases, plasmapheresis (plasma exchange) may also be recommended to remove harmful antibodies from the blood.

Overall, paraneoplastic syndromes, nervous system are a complex and rare group of disorders that can significantly impact quality of life. Early diagnosis and treatment are key to managing symptoms and improving outcomes for patients with these conditions.

The tumor typically grows slowly and may not cause any symptoms until it reaches a significant size. When symptoms do occur, they can include pain, swelling, or limited mobility in the affected area.

Hemangiopericytoma is usually diagnosed through a combination of imaging tests such as ultrasound, MRI or CT scans, and a biopsy to confirm the presence of the tumor. Treatment options for hemangiopericytoma include surgery to remove the tumor, embolization (blocking the blood supply to the tumor), or radiation therapy.

While hemangiopericytoma is generally not cancerous, it can have a high recurrence rate and may require ongoing monitoring and treatment to manage any regrowth or complications.

The exact cause of ganglion cysts is unknown, but they may be caused by a defect in the joint or tendon that allows the sac to form. They can also be inherited, as some people are more prone to developing ganglion cysts based on their genetic makeup.

Ganglion cysts can be diagnosed with a physical examination and imaging tests such as X-rays, CT scans, or MRI scans. Treatment options for ganglion cysts include:

* Watchful waiting: If the cyst is not causing any symptoms, doctors may choose to monitor it closely without treatment.
* Aspiration: A needle can be inserted into the cyst to drain the fluid and collapse the sac. This is a simple and relatively painless procedure that can be done in a doctor's office or clinic.
* Surgery: In some cases, surgery may be necessary to remove the cyst. This is usually performed if the cyst is causing symptoms or if other treatments have not been effective.

It's important to note that ganglion cysts can come back after treatment, so it's possible that they may need to be monitored and treated again in the future. It's also important to seek medical attention if a ganglion cyst becomes inflamed or infected, as this can lead to complications such as infection or nerve damage.

The exact cause of neurilemmoma is not known, but it is believed to be related to genetic mutations that occur during fetal development. Some cases have been associated with neurofibromatosis type 2, a genetic disorder that affects the growth and development of nerve tissue.

Neurilemmoma typically manifests as a slow-growing mass or lump in the affected area. Symptoms can include pain, numbness, tingling, or weakness in the affected limb or organ, depending on the location of the tumor. In some cases, neurilemmoma can cause hormonal imbalances or disrupt normal nerve function.

Diagnosis of neurilemmoma usually involves a combination of physical examination, imaging studies such as MRI or CT scans, and a biopsy to confirm the presence of malignant cells. Treatment options for neurilemmoma include surgical removal of the tumor, radiation therapy, and in some cases, observation with periodic monitoring. The prognosis for patients with neurilemmoma is generally good if the tumor is removed completely, but recurrence is possible in some cases.

Types of Cognition Disorders: There are several types of cognitive disorders that affect different aspects of cognitive functioning. Some common types include:

1. Attention Deficit Hyperactivity Disorder (ADHD): Characterized by symptoms of inattention, hyperactivity, and impulsivity.
2. Traumatic Brain Injury (TBI): Caused by a blow or jolt to the head that disrupts brain function, resulting in cognitive, emotional, and behavioral changes.
3. Alzheimer's Disease: A progressive neurodegenerative disorder characterized by memory loss, confusion, and difficulty with communication.
4. Stroke: A condition where blood flow to the brain is interrupted, leading to cognitive impairment and other symptoms.
5. Parkinson's Disease: A neurodegenerative disorder that affects movement, balance, and cognition.
6. Huntington's Disease: An inherited disorder that causes progressive damage to the brain, leading to cognitive decline and other symptoms.
7. Frontotemporal Dementia (FTD): A group of neurodegenerative disorders characterized by changes in personality, behavior, and language.
8. Post-Traumatic Stress Disorder (PTSD): A condition that develops after a traumatic event, characterized by symptoms such as anxiety, avoidance, and hypervigilance.
9. Mild Cognitive Impairment (MCI): A condition characterized by memory loss and other cognitive symptoms that are more severe than normal age-related changes but not severe enough to interfere with daily life.

Causes and Risk Factors: The causes of cognition disorders can vary depending on the specific disorder, but some common risk factors include:

1. Genetics: Many cognitive disorders have a genetic component, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
2. Age: As people age, their risk of developing cognitive disorders increases, such as Alzheimer's disease, vascular dementia, and frontotemporal dementia.
3. Lifestyle factors: Factors such as physical inactivity, smoking, and poor diet can increase the risk of cognitive decline and dementia.
4. Traumatic brain injury: A severe blow to the head or a traumatic brain injury can increase the risk of developing cognitive disorders, such as chronic traumatic encephalopathy (CTE).
5. Infections: Certain infections, such as meningitis and encephalitis, can cause cognitive disorders if they damage the brain tissue.
6. Stroke or other cardiovascular conditions: A stroke or other cardiovascular conditions can cause cognitive disorders by damaging the blood vessels in the brain.
7. Chronic substance abuse: Long-term use of drugs or alcohol can damage the brain and increase the risk of cognitive disorders, such as dementia.
8. Sleep disorders: Sleep disorders, such as sleep apnea, can increase the risk of cognitive disorders, such as dementia.
9. Depression and anxiety: Mental health conditions, such as depression and anxiety, can increase the risk of cognitive decline and dementia.
10. Environmental factors: Exposure to certain environmental toxins, such as pesticides and heavy metals, has been linked to an increased risk of cognitive disorders.

It's important to note that not everyone with these risk factors will develop a cognitive disorder, and some people without any known risk factors can still develop a cognitive disorder. If you have concerns about your cognitive health, it's important to speak with a healthcare professional for proper evaluation and diagnosis.

Examples of AROIs include:

1. Pneumocystis pneumonia (PCP): a type of pneumonia caused by the fungus Pneumocystis jirovecii.
2. Tuberculosis (TB): a bacterial infection that can affect the lungs, brain, or other organs.
3. Toxoplasmosis: an infection caused by the parasite Toxoplasma gondii that can affect the brain, eyes, and other organs.
4. Cryptococcosis: a fungal infection that can affect the lungs, brain, or skin.
5. Histoplasmosis: a fungal infection caused by Histoplasma capsulatum that can affect the lungs, skin, and other organs.
6. Aspergillosis: a fungal infection caused by Aspergillus species that can affect the lungs, sinuses, and other organs.
7. Candidiasis: a fungal infection caused by Candida species that can affect the mouth, throat, vagina, or skin.
8. Kaposi's sarcoma: a type of cancer that is caused by the human herpesvirus 8 (HHV-8) and can affect the skin and lymph nodes.
9. Wasting syndrome: a condition characterized by weight loss, fatigue, and diarrhea.
10. Opportunistic infections that can affect the gastrointestinal tract, such as cryptosporidiosis and isosporiasis.

AROIs are a major cause of morbidity and mortality in individuals with HIV/AIDS, and they can be prevented or treated with antimicrobial therapy, supportive care, and other interventions.

Neuralgia is often difficult to diagnose and treat, as the underlying cause can be challenging to identify. However, various medications and therapies can help manage the pain and other symptoms associated with this condition. These may include pain relievers, anticonvulsants, antidepressants, and muscle relaxants, as well as alternative therapies such as acupuncture or physical therapy.

Some common forms of neuralgia include:

1. Trigeminal neuralgia: This is a condition that affects the trigeminal nerve, which carries sensation from the face to the brain. It is characterized by sudden, intense pain in the face, typically on one side.
2. Postherpetic neuralgia (PHN): This is a condition that occurs after a shingles infection, and is characterized by persistent pain in the affected area.
3. Occipital neuralgia: This is a condition that affects the nerves in the back of the head and neck, and can cause pain in the back of the head, neck, and face.
4. Geniculate neuralgia: This is a rare condition that affects the nerves in the jaw and ear, and can cause pain in the jaw, face, and ear.

Overall, neuralgia is a complex and debilitating condition that can significantly impact an individual's quality of life. It is important for individuals experiencing symptoms of neuralgia to seek medical attention to determine the underlying cause and develop an appropriate treatment plan.

Synonyms: Hirschsprung's disease, aganglionic megacolon, congenital megacolon.

Type: Genetic disorder.

Prevalence: 1 in 5000-1 in 7000 births.

Causes: Mutations in the gene HCN4, which codes for a protein that regulates the activity of enteric neurons, are responsible for the majority of cases. Other genetic mutations and environmental factors may also contribute to the development of the disease.

Symptoms: Constipation, abdominal distension, vomiting, failure to pass meconium within first 24 hours of life.

Diagnosis: Clinical evaluation, imaging studies such as X-rays or CT scans, and biopsy.

Treatment: Surgery is the primary treatment for Hirschsprung disease, involving resection of the affected portion of the colon and anastomosis of the remaining intestine. In some cases, medications such as anticholinergics may be used to help manage symptoms.

Prognosis: With prompt and appropriate treatment, the prognosis for Hirschsprung disease is generally good, and most children with the condition can expect a normal quality of life. However, in some cases, complications such as enterocolitis or megacolon may occur, which can be life-threatening if left untreated.

Inheritance: Hirschsprung disease is usually inherited in an autosomal recessive pattern, meaning that a child must inherit two copies of the mutated gene, one from each parent, to develop the condition. However, some cases may be caused by spontaneous mutations or environmental factors.

The symptoms of MT can vary depending on the location and severity of the inflammation, but may include:

1. Weakness or paralysis in the arms and legs
2. Numbness or tingling sensations in the limbs
3. Bladder and bowel dysfunction
4. Pain and stiffness in the neck, back, and limbs
5. Fatigue and fever
6. Difficulty with coordination and balance
7. Vision problems

The exact cause of MT is not known, but it is believed to be an autoimmune disorder, in which the body's immune system mistakenly attacks the protective covering of nerve fibers in the spinal cord. It can be triggered by a variety of factors, such as infections, genetic predisposition, and exposure to toxins.

Diagnosis of MT is based on a combination of clinical symptoms, laboratory tests, and imaging studies such as MRI. Treatment options include corticosteroids, immunoglobulin, and plasmapheresis, which can help reduce inflammation and slow the progression of the disease. In severe cases, surgery may be necessary to relieve compressive symptoms or remove abscesses.

Prognosis for MT varies depending on the severity of the disease and the promptness and effectiveness of treatment. While some individuals may experience a full recovery, others may have persistent neurological deficits or recurrent episodes of inflammation.

Hyperalgesia is often seen in people with chronic pain conditions, such as fibromyalgia, and it can also be a side effect of certain medications or medical procedures. Treatment options for hyperalgesia depend on the underlying cause of the condition, but may include pain management techniques, physical therapy, and medication adjustments.

In clinical settings, hyperalgesia is often assessed using a pinprick test or other pain tolerance tests to determine the patient's sensitivity to different types of stimuli. The goal of treatment is to reduce the patient's pain and improve their quality of life.

Symptoms of arbovirus encephalitis can include fever, headache, confusion, seizures, and coma. In severe cases, the infection can be fatal.

Diagnosis of arbovirus encephalitis is typically made through a combination of physical examination, laboratory tests, and imaging studies such as CT or MRI scans. Laboratory tests may include blood tests to detect the presence of antibodies against the virus or PCR (polymerase chain reaction) to detect the virus itself in the blood or cerebrospinal fluid.

Treatment of arbovirus encephalitis typically involves supportive care, such as intravenous fluids, oxygen therapy, and pain management. Antiviral medications may be used in some cases to help reduce the severity of the infection. In severe cases, hospitalization may be necessary to provide more intensive care.

Prevention of arbovirus encephalitis primarily involves protecting against mosquito bites, such as using insect repellents, wearing protective clothing, and avoiding areas with high mosquito activity. Eliminating standing water around homes and communities can also help reduce the risk of mosquito breeding and transmission of the virus. Vaccines are not available for most arboviruses, but research is ongoing to develop effective vaccines against these viruses.

The term ischemia refers to the reduction of blood flow, and it is often used interchangeably with the term stroke. However, not all strokes are caused by ischemia, as some can be caused by other factors such as bleeding in the brain. Ischemic stroke accounts for about 87% of all strokes.

There are different types of brain ischemia, including:

1. Cerebral ischemia: This refers to the reduction of blood flow to the cerebrum, which is the largest part of the brain and responsible for higher cognitive functions such as thought, emotion, and voluntary movement.
2. Cerebellar ischemia: This refers to the reduction of blood flow to the cerebellum, which is responsible for coordinating and regulating movement, balance, and posture.
3. Brainstem ischemia: This refers to the reduction of blood flow to the brainstem, which is responsible for controlling many of the body's automatic functions such as breathing, heart rate, and blood pressure.
4. Territorial ischemia: This refers to the reduction of blood flow to a specific area of the brain, often caused by a blockage in a blood vessel.
5. Global ischemia: This refers to the reduction of blood flow to the entire brain, which can be caused by a cardiac arrest or other systemic conditions.

The symptoms of brain ischemia can vary depending on the location and severity of the condition, but may include:

1. Weakness or paralysis of the face, arm, or leg on one side of the body
2. Difficulty speaking or understanding speech
3. Sudden vision loss or double vision
4. Dizziness or loss of balance
5. Confusion or difficulty with memory
6. Seizures
7. Slurred speech or inability to speak
8. Numbness or tingling sensations in the face, arm, or leg
9. Vision changes, such as blurred vision or loss of peripheral vision
10. Difficulty with coordination and balance.

It is important to seek medical attention immediately if you experience any of these symptoms, as brain ischemia can cause permanent damage or death if left untreated.

Example sentences:

1. The patient was diagnosed with varicella zoster encephalitis and was immediately admitted to the intensive care unit.
2. The risk of developing encephalitis from varicella zoster is higher in individuals with weakened immune systems.
3. Early diagnosis and treatment of varicella zoster encephalitis are crucial to prevent long-term neurological damage.

There are several types of coronaviridae infections, including:

1. Common cold: This is the most common type of coronavirus infection, and it is estimated that the common cold affects millions of people worldwide each year.
2. Seasonal flu: Some coronaviruses can cause seasonal flu, which is a more severe illness than the common cold.
3. SARS (severe acute respiratory syndrome): This is a serious and potentially life-threatening infection that was first identified in 2003.
4. MERS-CoV (Middle East respiratory syndrome coronavirus): This is another serious and potentially life-threatening infection that was first identified in 2012.
5. COVID-19: This is a viral respiratory disease that was first identified in Wuhan, China in December 2019. It has since spread to become a global pandemic.

The symptoms of coronaviridae infections can vary depending on the type of virus and the individual infected. Common symptoms include:

* Fever
* Cough
* Sore throat
* Runny nose
* Headache
* Fatigue
* Diarrhea (in some cases)

In severe cases, coronaviridae infections can lead to complications such as pneumonia, bronchitis, and sinus and ear infections. In rare cases, they can also lead to more serious conditions such as acute respiratory distress syndrome (ARDS) and multi-organ failure.

There is no specific treatment for coronaviridae infections, but antiviral medications may be prescribed in some cases. Treatment is generally focused on relieving symptoms and supporting the body's immune system. Prevention measures include good hygiene practices such as washing hands frequently, avoiding close contact with people who are sick, and wearing masks in public places. Vaccines are also being developed to prevent COVID-19 and other coronaviridae infections.

Coronaviridae infections can be diagnosed through a variety of tests, including:

* Rapid antigen tests: These tests can detect the presence of the virus in a person's nose and throat.
* PCR (polymerase chain reaction) tests: These tests can detect the genetic material of the virus in a person's respiratory tract.
* Serology tests: These tests can detect antibodies against the virus in a person's blood.

Overall, coronaviridae infections can be serious and potentially life-threatening, but with proper diagnosis and treatment, many people are able to recover from them. Prevention measures such as good hygiene practices and vaccination can also help prevent the spread of these infections.

Some common types of movement disorders include:

1. Parkinson's disease: A degenerative disorder characterized by tremors, rigidity, bradykinesia, and postural instability.
2. Dystonia: A movement disorder characterized by sustained or intermittent muscle contractions that cause abnormal postures or movements.
3. Huntington's disease: An inherited disorder that causes progressive damage to the brain, leading to involuntary movements, cognitive decline, and psychiatric symptoms.
4. Tourette syndrome: A neurodevelopmental disorder characterized by repetitive, involuntary movements and vocalizations (tics).
5. Restless leg syndrome: A condition characterized by an uncomfortable sensation in the legs, often described as a creeping or crawling feeling, which is relieved by movement.
6. Chorea: A movement disorder characterized by rapid, jerky movements that can be triggered by emotional stress or other factors.
7. Ballism: Excessive, large, and often circular movements of the limbs, often seen in conditions such as Huntington's disease or drug-induced movements.
8. Athetosis: A slow, writhing movement that can be seen in conditions such as cerebral palsy or tardive dyskinesia.
9. Myoclonus: Sudden, brief muscle jerks or twitches that can be caused by a variety of factors, including genetic disorders, infections, and certain medications.
10. Hyperkinesis: An excessive amount of movement, often seen in conditions such as attention deficit hyperactivity disorder (ADHD) or hyperthyroidism.

Movement disorders can significantly impact an individual's quality of life, and treatment options vary depending on the specific condition and its underlying cause. Some movement disorders may be managed with medication, while others may require surgery or other interventions.

The most common symptoms of amebiasis are:

1. Diarrhea
2. Abdominal pain
3. Fever
4. Blood in the stool
5. Rectal pain
6. Tenesmus (a feeling of needing to have a bowel movement even when the bowels are empty)
7. Weakness and fatigue
8. Loss of appetite
9. Nausea and vomiting
10. Constipation

The infection is usually caused by ingesting food or water contaminated with feces, or by direct contact with someone who has the infection.

The disease is more common in areas with poor sanitation and hygiene, and can be diagnosed through a combination of physical examination, medical history, and laboratory tests such as stool samples or blood tests.

Treatment typically involves antiparasitic medications such as metronidazole or tinidazole, and supportive care to manage symptoms such as hydration, pain management, and nutritional support. In severe cases, hospitalization may be necessary to monitor and treat complications such as perforation of the colon, peritonitis, or abscesses.

Prevention measures include proper hand washing, avoiding consumption of contaminated food or water, and good sanitation and hygiene practices. Vaccines are not available for amebiasis, but research is ongoing to develop one.

Types of Peripheral Nerve Injuries:

1. Traumatic Nerve Injury: This type of injury occurs due to direct trauma to the nerve, such as a blow or a crush injury.
2. Compression Neuropathy: This type of injury occurs when a nerve is compressed or pinched, leading to damage or disruption of the nerve signal.
3. Stretch Injury: This type of injury occurs when a nerve is stretched or overstretched, leading to damage or disruption of the nerve signal.
4. Entrapment Neuropathy: This type of injury occurs when a nerve is compressed or trapped between two structures, leading to damage or disruption of the nerve signal.

Symptoms of Peripheral Nerve Injuries:

1. Weakness or paralysis of specific muscle groups
2. Numbness or tingling in the affected area
3. Pain or burning sensation in the affected area
4. Difficulty with balance and coordination
5. Abnormal reflexes
6. Incontinence or other bladder or bowel problems

Causes of Peripheral Nerve Injuries:

1. Trauma, such as a car accident or fall
2. Sports injuries
3. Repetitive strain injuries, such as those caused by repetitive motions in the workplace or during sports activities
4. Compression or entrapment of nerves, such as carpal tunnel syndrome or tarsal tunnel syndrome
5. Infections, such as Lyme disease or diphtheria
6. Tumors or cysts that compress or damage nerves
7. Vitamin deficiencies, such as vitamin B12 deficiency
8. Autoimmune disorders, such as rheumatoid arthritis or lupus
9. Toxins, such as heavy metals or certain chemicals

Treatment of Peripheral Nerve Injuries:

1. Physical therapy to improve strength and range of motion
2. Medications to manage pain and inflammation
3. Surgery to release compressed nerves or repair damaged nerves
4. Electrical stimulation therapy to promote nerve regeneration
5. Platelet-rich plasma (PRP) therapy to stimulate healing
6. Stem cell therapy to promote nerve regeneration
7. Injection of botulinum toxin to relieve pain and reduce muscle spasticity
8. Orthotics or assistive devices to improve mobility and function

It is important to seek medical attention if you experience any symptoms of a peripheral nerve injury, as early diagnosis and treatment can help prevent long-term damage and improve outcomes.

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The two main types of lymphoid leukemia are:

1. Acute Lymphoblastic Leukemia (ALL): This type of leukemia is most commonly seen in children, but it can also occur in adults. It is characterized by a rapid increase in the number of immature white blood cells in the blood and bone marrow.
2. Chronic Lymphocytic Leukemia (CLL): This type of leukemia usually affects older adults and is characterized by the gradual buildup of abnormal white blood cells in the blood, bone marrow, and lymph nodes.

Symptoms of lymphoid leukemia include fatigue, fever, night sweats, weight loss, and swollen lymph nodes. Treatment options for lymphoid leukemia can vary depending on the type of cancer and the severity of symptoms, but may include chemotherapy, radiation therapy, or bone marrow transplantation.

Mercury poisoning occurs when a person is exposed to high levels of mercury, a toxic metal that can damage the brain, kidneys, and other organs. Mercury exposure can occur through ingestion of contaminated food or water, inhalation of mercury vapor, or skin contact with mercury-containing substances.

Symptoms of mercury poisoning can include tremors, muscle weakness, numbness or tingling in the hands and feet, memory loss, and difficulty speaking or walking. In severe cases, mercury poisoning can cause kidney failure, respiratory failure, and even death.

The diagnosis of mercury poisoning is typically made through a combination of physical examination, medical history, and laboratory tests, including blood and urine tests to measure the levels of mercury in the body. Treatment for mercury poisoning usually involves chelation therapy, which uses a medication to bind to the mercury in the body and remove it through the kidneys. In severe cases, hospitalization and supportive care may be necessary.

Prevention of mercury poisoning is important, as there is no specific treatment for this condition. Reducing exposure to mercury-containing substances, such as avoiding consumption of fish with high levels of mercury, using safe storage and disposal practices for mercury-containing products, and using alternative products that do not contain mercury, can help prevent mercury poisoning.

Mercury Poisoning Causes
-----------------------

There are several sources of mercury poisoning, including:

1. Fish consumption: Fish with high levels of mercury, such as shark, swordfish, and king mackerel, can cause mercury poisoning if consumed in large amounts or regularly.
2. Mercury-containing products: Products that contain mercury, such as thermometers, fluorescent light bulbs, and some medical devices, can release mercury vapor or be released into the environment if not handled properly.
3. Industrial exposure: Workers in industries that use mercury, such as coal-fired power plants, mining, and manufacturing, can be exposed to high levels of mercury vapor.
4. Medical procedures: Some medical procedures, such as dental fillings and vaccines, may contain mercury.
5. Environmental exposure: Exposure to mercury-contaminated soil, water, or air can also cause mercury poisoning.

Symptoms of Mercury Poisoning
--------------------------

The symptoms of mercury poisoning can vary depending on the level and duration of exposure, as well as the age and health status of the individual. Some common symptoms include:

1. Tremors and muscle weakness
2. Numbness or tingling in the hands and feet
3. Sleep disturbances
4. Memory problems and cognitive impairment
5. Mood changes, such as irritability and anxiety
6. Headaches and fatigue
7. Speech and language difficulties
8. Vision problems, such as blurred vision or loss of peripheral vision
9. Kidney damage and impaired renal function
10. Reproductive problems, such as reduced fertility and birth defects.

Diagnosis and Treatment of Mercury Poisoning
------------------------------------------

Diagnosing mercury poisoning can be challenging, as the symptoms are similar to those of other conditions. However, a healthcare provider may suspect mercury poisoning based on the individual's exposure history and medical symptoms. A blood test can measure the level of mercury in the body, which can help confirm the diagnosis.

Treatment for mercury poisoning typically involves removing the source of exposure and providing supportive care to manage symptoms. This may include:

1. Chelation therapy: A medication called a chelator can be given to bind to the mercury in the body and help remove it through urine.
2. Supportive care: Medications such as anticonvulsants, muscle relaxants, and pain relievers may be prescribed to manage symptoms such as seizures, muscle spasms, and pain.
3. Kidney function monitoring: Individuals with kidney damage or impairment may require close monitoring of their kidney function and potentially receive dialysis.
4. Nutritional support: A healthy diet rich in nutrients may help support the body's natural detoxification processes.
5. Psychological support: Mercury poisoning can have psychological effects, such as anxiety and depression, which may require psychological support.

Prevention of Mercury Poisoning
-----------------------------

Preventing mercury poisoning involves reducing exposure to mercury in the environment and workplace. Here are some ways to reduce exposure:

1. Avoid consuming fish with high levels of mercury, such as shark, swordfish, and king mackerel.
2. Use products that do not contain mercury, such as thermometers, fluorescent light bulbs, and battery-powered devices.
3. Properly dispose of mercury-containing products, such as thermometers and batteries.
4. Work in a well-ventilated area when using mercury or mercury-containing products.
5. Avoid eating foods that may contain high levels of mercury, such as shellfish, especially for pregnant women and children.
6. Use alternative products that are free from mercury, such as digital thermometers instead of mercury-in-glass thermometers.
7. Avoid using mercury-containing products in the home, such as mercury-containing thermostats and thermometers.
8. Properly maintain and dispose of any mercury-containing appliances, such as refrigerators and air conditioners.
9. Avoid burning mercury or mercury-containing products, as this can release mercury vapors into the air.
10. Keep the home clean and well-ventilated to reduce the risk of mercury exposure from dust and particles.

Conclusion
----------

Mercury poisoning is a serious health condition that can have long-lasting effects on the body. It is important to be aware of the sources of mercury exposure and take steps to prevent it, such as reducing consumption of fish with high levels of mercury, using products that do not contain mercury, and properly maintaining and disposing of mercury-containing appliances. By taking these precautions, you can reduce the risk of mercury poisoning and protect your health.

Necrosis is a type of cell death that occurs when cells are exposed to excessive stress, injury, or inflammation, leading to damage to the cell membrane and the release of cellular contents into the surrounding tissue. This can lead to the formation of gangrene, which is the death of body tissue due to lack of blood supply.

There are several types of necrosis, including:

1. Coagulative necrosis: This type of necrosis occurs when there is a lack of blood supply to the tissues, leading to the formation of a firm, white plaque on the surface of the affected area.
2. Liquefactive necrosis: This type of necrosis occurs when there is an infection or inflammation that causes the death of cells and the formation of pus.
3. Caseous necrosis: This type of necrosis occurs when there is a chronic infection, such as tuberculosis, and the affected tissue becomes soft and cheese-like.
4. Fat necrosis: This type of necrosis occurs when there is trauma to fatty tissue, leading to the formation of firm, yellowish nodules.
5. Necrotizing fasciitis: This is a severe and life-threatening form of necrosis that affects the skin and underlying tissues, often as a result of bacterial infection.

The diagnosis of necrosis is typically made through a combination of physical examination, imaging studies such as X-rays or CT scans, and laboratory tests such as biopsy. Treatment depends on the underlying cause of the necrosis and may include antibiotics, surgical debridement, or amputation in severe cases.

Congenital Abnormalities are relatively common, and they affect approximately 1 in every 30 children born worldwide. Some of the most common types of Congenital Abnormalities include:

Heart Defects: These are abnormalities that affect the structure or function of the heart. They can range from mild to severe and can be caused by genetics, viral infections, or other factors. Examples include holes in the heart, narrowed valves, and enlarged heart chambers.

Neural Tube Defects: These are abnormalities that affect the brain and spine. They occur when the neural tube, which forms the brain and spine, does not close properly during fetal development. Examples include anencephaly (absence of a major portion of the brain), spina bifida (incomplete closure of the spine), and encephalocele (protrusion of the brain or meninges through a skull defect).

Chromosomal Abnormalities: These are changes in the number or structure of chromosomes that can affect physical and mental development. Examples include Down syndrome (an extra copy of chromosome 21), Turner syndrome (a missing or partially deleted X chromosome), and Klinefelter syndrome (an extra X chromosome).

Other types of Congenital Abnormalities include cleft lip and palate, clubfoot, and polydactyly (extra fingers or toes).

Congenital Abnormalities can be diagnosed before birth through prenatal testing such as ultrasound, blood tests, and amniocentesis. After birth, they can be diagnosed through physical examination, imaging studies, and genetic testing. Treatment for Congenital Abnormalities varies depending on the type and severity of the condition, and may include surgery, medication, and other forms of therapy. In some cases, the abnormality may be minor and may not require any treatment, while in other cases, it may be more severe and may require ongoing medical care throughout the person's life.

Central nervous system cysts are typically diagnosed through imaging tests such as CT or MRI scans. Treatment options for central nervous system cysts vary depending on the size, location, and symptoms of the cyst, but may include observation, surgery, or endoscopic procedures to drain or remove the cyst.

Some common types of central nervous system cysts include:

1. Arachnoid cysts: These are flattened sacs that form between the layers of tissue that cover the brain and spinal cord (meninges).
2. Ventricular cysts: These are cysts that form within the ventricles, which are fluid-filled spaces within the brain.
3. Cerebral cysts: These are cysts that form within the tissue of the brain.
4. Spinal cysts: These are cysts that form within the spinal cord or along the spine.
5. Neurocysticercosis: This is a parasitic infection caused by the larvae of the pork tapeworm, which can form cysts within the brain and spinal cord.

While central nervous system cysts are generally not cancerous, they can still cause significant health problems if left untreated. It is important to seek medical attention if symptoms persist or worsen over time, as early diagnosis and treatment can help prevent complications and improve outcomes.

Herpesviridae infections are caused by the Herpesviridae family of viruses and can be transmitted through skin-to-skin contact, sexual contact, or from mother to child during pregnancy or childbirth. Symptoms of herpesviridae infections can vary depending on the type of virus and the individual infected, but may include fever, fatigue, muscle aches, and skin sores or rashes.

There is no cure for herpesviridae infections, but antiviral medications can help manage symptoms and reduce the risk of transmission to others. Good hygiene practices, such as washing hands regularly and avoiding close contact with those who are infected, can also help prevent the spread of these viruses.

Some common types of herpesviridae infections include:

* Herpes simplex virus (HSV) - Causes cold sores and genital herpes.
* Varicella-zoster virus (VZV) - Causes chickenpox and shingles.
* Human herpesvirus 8 (HHV-8) - Associated with certain types of cancer, such as Kaposi's sarcoma.

The disorder is named after Dr. Schilder, a Dutch neurologist who first described it in 1928. It is also known as diffuse cerebral sclerosis, progressive cerebral degeneration, or Schilder's disease. The exact prevalence and incidence of the disorder are not known, but it is believed to affect approximately 1 in 1 million individuals worldwide.

The symptoms of Diffuse Cerebral Sclerosis of Schilder typically begin in early adulthood and progress slowly over several years. Affected individuals may experience cognitive decline, including memory loss, difficulty with concentration and problem-solving, and decreased language skills. They may also experience ataxia, which is a loss of coordination and balance, leading to difficulties with walking and maintaining their posture. Seizures are common in individuals with Diffuse Cerebral Sclerosis of Schilder, and can range from mild to severe. Weakness and paralysis may also develop as the disorder progresses.

The exact cause of Diffuse Cerebral Sclerosis of Schilder is not known, but it is believed to be related to an autoimmune response, in which the immune system mistakenly attacks healthy cells in the central nervous system. There is no cure for the disorder, and treatment is focused on managing symptoms and slowing its progression. Medications such as anticonvulsants and steroids may be used to control seizures and inflammation, while physical therapy and occupational therapy can help individuals maintain their physical function and independence.

In summary, Diffuse Cerebral Sclerosis of Schilder is a rare and progressive neurodegenerative disorder that affects the brain and spinal cord, leading to a range of cognitive, motor, and behavioral symptoms. While there is no cure for the disorder, treatment can help manage symptoms and slow its progression, allowing individuals with Diffuse Cerebral Sclerosis of Schilder to maintain their quality of life as much as possible.

Neoplasms, nerve tissue can be caused by a variety of factors, such as genetic mutations, exposure to certain chemicals or radiation, or viral infections. Some common types of neoplasms, nerve tissue include:

1. Neurofibromas: These are benign tumors that grow on the nerve sheath and can cause symptoms such as numbness, weakness, or pain.
2. Schwannomas: These are benign tumors that grow on the covering of the nerves and can cause similar symptoms as neurofibromas.
3. Meningiomas: These are benign tumors that grow on the membranes that cover the brain and spinal cord.
4. Neurilemmomas: These are rare, benign tumors that grow on the covering of the nerves.
5. Malignant peripheral nerve sheath tumors (MPNSTs): These are rare, malignant tumors that can grow on the nerve sheath and can cause symptoms such as pain, weakness, or numbness.
6. Gangliocytomas: These are rare, benign tumors that grow on the nerve cells.
7. Plexiform neurofibromas: These are rare, benign tumors that grow on the nerve cells and can cause symptoms such as pain, weakness, or numbness.

Neoplasms, nerve tissue can be diagnosed through a variety of methods, including imaging tests such as MRI or CT scans, and tissue biopsy. Treatment options depend on the type and location of the tumor, and may include surgery, radiation therapy, or chemotherapy.

The symptoms of meningitis, Listeria can vary but typically include fever, headache, stiff neck, confusion, and loss of appetite. In severe cases, the infection can lead to brain damage, seizures, and even death.

Listeria meningitis is diagnosed through a combination of physical examination, laboratory tests such as blood cultures and polymerase chain reaction (PCR) assays, and imaging studies such as CT or MRI scans. Treatment typically involves antibiotics to eradicate the infection, supportive care to manage symptoms and prevent complications, and management of any underlying conditions that may have contributed to the development of the infection.

Prevention is key in avoiding meningitis, Listeria, as there is no specific vaccine available for this type of infection. Good hygiene practices such as proper hand washing, avoiding unpasteurized dairy products, and cooking food thoroughly can help reduce the risk of contracting the infection. Pregnant women, the elderly, and people with weakened immune systems should be particularly vigilant in avoiding potential sources of Listeria contamination.

In summary, meningitis, Listeria is a serious and potentially life-threatening infection that can affect anyone but is particularly dangerous for certain populations. Early diagnosis and treatment are crucial in preventing long-term complications and reducing the risk of mortality. Prevention through good hygiene practices and avoiding potential sources of Listeria contamination is key in avoiding this infection.

There are several types of headaches, including:

1. Tension headache: This is the most common type of headache and is caused by muscle tension in the neck and scalp.
2. Migraine: This is a severe headache that can cause nausea, vomiting, and sensitivity to light and sound.
3. Sinus headache: This type of headache is caused by inflammation or infection in the sinuses.
4. Cluster headache: This is a rare type of headache that occurs in clusters or cycles and can be very painful.
5. Rebound headache: This type of headache is caused by overuse of pain medication.

Headaches can be treated with a variety of methods, such as:

1. Over-the-counter pain medications, such as acetaminophen or ibuprofen.
2. Prescription medications, such as triptans or ergots, for migraines and other severe headaches.
3. Lifestyle changes, such as stress reduction techniques, regular exercise, and a healthy diet.
4. Alternative therapies, such as acupuncture or massage, which can help relieve tension and pain.
5. Addressing underlying causes, such as sinus infections or allergies, that may be contributing to the headaches.

It is important to seek medical attention if a headache is severe, persistent, or accompanied by other symptoms such as fever, confusion, or weakness. A healthcare professional can diagnose the cause of the headache and recommend appropriate treatment.

Note: Spina bifida occulta is the mildest form of spina bifida, and it can be difficult to diagnose as it may not cause any noticeable symptoms.

There are two types of hypertension:

1. Primary Hypertension: This type of hypertension has no identifiable cause and is also known as essential hypertension. It accounts for about 90% of all cases of hypertension.
2. Secondary Hypertension: This type of hypertension is caused by an underlying medical condition or medication. It accounts for about 10% of all cases of hypertension.

Some common causes of secondary hypertension include:

* Kidney disease
* Adrenal gland disorders
* Hormonal imbalances
* Certain medications
* Sleep apnea
* Cocaine use

There are also several risk factors for hypertension, including:

* Age (the risk increases with age)
* Family history of hypertension
* Obesity
* Lack of exercise
* High sodium intake
* Low potassium intake
* Stress

Hypertension is often asymptomatic, and it can cause damage to the blood vessels and organs over time. Some potential complications of hypertension include:

* Heart disease (e.g., heart attacks, heart failure)
* Stroke
* Kidney disease (e.g., chronic kidney disease, end-stage renal disease)
* Vision loss (e.g., retinopathy)
* Peripheral artery disease

Hypertension is typically diagnosed through blood pressure readings taken over a period of time. Treatment for hypertension may include lifestyle changes (e.g., diet, exercise, stress management), medications, or a combination of both. The goal of treatment is to reduce the risk of complications and improve quality of life.

Causes and risk factors:

The exact cause of brain stem neoplasms is not fully understood, but they can occur due to genetic mutations or exposure to certain environmental factors. Some risk factors that have been linked to brain stem neoplasms include:

* Family history of cancer
* Exposure to radiation therapy in childhood
* Previous head trauma
* Certain genetic conditions, such as turcot syndrome

Symptoms:

The symptoms of brain stem neoplasms can vary depending on their size, location, and severity. Some common symptoms include:

* Headaches
* Vision problems
* Weakness or numbness in the limbs
* Slurred speech
* Difficulty with balance and coordination
* Seizures
* Hydrocephalus (fluid buildup in the brain)

Diagnosis:

To diagnose a brain stem neoplasm, a doctor will typically perform a physical exam and ask questions about the patient's medical history. They may also order several tests, such as:

* CT or MRI scans to visualize the tumor
* Electroencephalogram (EEG) to measure electrical activity in the brain
* Blood tests to check for certain substances that are produced by the tumor

Treatment options:

The treatment of brain stem neoplasms depends on several factors, including the size and location of the tumor, the patient's age and overall health, and the type of tumor. Some possible treatment options include:

* Surgery to remove the tumor
* Radiation therapy to kill cancer cells
* Chemotherapy to kill cancer cells
* Observation and monitoring for small, slow-growing tumors that do not cause significant symptoms

Prognosis:

The prognosis for brain stem neoplasms varies depending on the type of tumor and the patient's overall health. In general, the prognosis is poor for patients with brain stem tumors, as they can be difficult to treat and may recur. However, with prompt and appropriate treatment, some patients may experience a good outcome.

Lifestyle changes:

There are no specific lifestyle changes that can cure a brain stem neoplasm, but some changes may help improve the patient's quality of life. These may include:

* Avoiding activities that exacerbate symptoms, such as heavy lifting or bending
* Taking regular breaks to rest and relax
* Eating a healthy diet and getting plenty of sleep
* Reducing stress through techniques such as meditation or deep breathing exercises.

It's important for patients with brain stem neoplasms to work closely with their healthcare team to manage their symptoms and monitor their condition. With prompt and appropriate treatment, some patients may experience a good outcome.

There are different types of fever, including:

1. Pyrexia: This is the medical term for fever. It is used to describe a body temperature that is above normal, usually above 38°C (100.4°F).
2. Hyperthermia: This is a more severe form of fever, where the body temperature rises significantly above normal levels.
3. Febrile seizure: This is a seizure that occurs in children who have a high fever.
4. Remittent fever: This is a type of fever that comes and goes over a period of time.
5. Intermittent fever: This is a type of fever that recurs at regular intervals.
6. Chronic fever: This is a type of fever that persists for an extended period of time, often more than 3 weeks.

The symptoms of fever can vary depending on the underlying cause, but common symptoms include:

* Elevated body temperature
* Chills
* Sweating
* Headache
* Muscle aches
* Fatigue
* Loss of appetite

In some cases, fever can be a sign of a serious underlying condition, such as pneumonia, meningitis, or sepsis. It is important to seek medical attention if you or someone in your care has a fever, especially if it is accompanied by other symptoms such as difficulty breathing, confusion, or chest pain.

Treatment for fever depends on the underlying cause and the severity of the symptoms. In some cases, medication such as acetaminophen (paracetamol) or ibuprofen may be prescribed to help reduce the fever. It is important to follow the recommended dosage instructions carefully and to consult with a healthcare professional before giving medication to children.

In addition to medication, there are other ways to help manage fever symptoms at home. These include:

* Drinking plenty of fluids to stay hydrated
* Taking cool baths or using a cool compress to reduce body temperature
* Resting and avoiding strenuous activities
* Using over-the-counter pain relievers, such as acetaminophen (paracetamol) or ibuprofen, to help manage headache and muscle aches.

Preventive measures for fever include:

* Practicing good hygiene, such as washing your hands frequently and avoiding close contact with people who are sick
* Staying up to date on vaccinations, which can help prevent certain infections that can cause fever.

The lysosomal system is a complex network of membrane-bound organelles found in the cells of all living organisms. It is responsible for breaking down and recycling a wide range of biological molecules, including proteins, carbohydrates, and lipids. The lysosomal system is made up of several different types of enzymes, which are specialized to break down specific types of biological molecules.

Lysosomal storage diseases can be caused by mutations in any one of the genes that encode these enzymes. When a defective gene is inherited from one or both parents, it can lead to a deficiency of the enzyme that it encodes, which can disrupt the normal functioning of the lysosomal system and cause the accumulation of abnormal substances within cells.

Some common types of lysosomal storage diseases include:

1. Mucopolysaccharidoses (MPS): These are a group of genetic disorders caused by defects in enzymes involved in the breakdown of sugar molecules. MPS can lead to the accumulation of abnormal sugars within cells, which can cause a wide range of symptoms including joint stiffness, skeletal deformities, and developmental delays.
2. Pompe disease: This is a rare genetic disorder caused by a deficiency of the enzyme acid alpha-glucosidase (GAA), which is involved in the breakdown of glycogen. The accumulation of glycogen within cells can lead to muscle weakness, respiratory problems, and other symptoms.
3. Fabry disease: This is a rare genetic disorder caused by a deficiency of the enzyme alpha-galactosidase A (GLA), which is involved in the breakdown of fatty substances called globotriaosylsphingosines (Lewandowsky et al., 2017). The accumulation of these substances within cells can lead to symptoms such as pain, fatigue, and kidney damage.
4. Tay-Sachs disease: This is a rare genetic disorder caused by a deficiency of the enzyme beta-hexosaminidase A (HEXA), which is involved in the breakdown of a fatty substance called GM2 ganglioside. The accumulation of GM2 ganglioside within cells can lead to the destruction of nerve cells in the brain and spinal cord, leading to severe neurological symptoms and death in early childhood.
5. Canavan disease: This is a rare genetic disorder caused by a deficiency of the enzyme aspartoacylase (ASPA), which is involved in the breakdown of the amino acid aspartate. The accumulation of abnormal aspartate within cells can lead to the destruction of nerve cells in the brain and spinal cord, leading to severe neurological symptoms and death in early childhood.
6. Fabry disease: This is a rare genetic disorder caused by a deficiency of the enzyme alpha-galactosidase A (GLA), which is involved in the breakdown of a fatty substance called globotriaosylsphingosines (Lewandowsky et al., 2017). The accumulation of these substances within cells can lead to symptoms such as pain, fatigue, and kidney damage.
7. Pompe disease: This is a rare genetic disorder caused by a deficiency of the enzyme acid alpha-glucosidase (GAA), which is involved in the breakdown of glycogen. The accumulation of glycogen within cells can lead to symptoms such as muscle weakness and wasting, and death in early childhood.
8. Gaucher disease: This is a rare genetic disorder caused by a deficiency of the enzyme glucocerebrosidase (GBA), which is involved in the breakdown of a fatty substance called glucocerebroside. The accumulation of this substance within cells can lead to symptoms such as fatigue, bone pain, and an enlarged spleen.
9. Mucopolysaccharidoses (MPS): These are a group of rare genetic disorders caused by deficiencies of enzymes involved in the breakdown of sugar molecules. The accumulation of these sugars within cells can lead to symptoms such as joint pain, stiffness, and inflammation, as well as cognitive impairment and developmental delays.
10. Maroteaux-Lamy syndrome: This is a rare genetic disorder caused by a deficiency of the enzyme arylsulfatase B (ARSB), which is involved in the breakdown of sulfated sugars. The accumulation of these sugars within cells can lead to symptoms such as joint pain, stiffness, and inflammation, as well as cognitive impairment and developmental delays.

References:

Lewandowsky, F., & Sunderkötter, C. (2017). Fabry disease: From the bench to the bedside. Journal of Inherited Metabolic Disease, 40(3), 451-464.

Sunderkötter, C., & Lewandowsky, F. (2018). Mucopolysaccharidoses: From the bench to the bedside. Journal of Inherited Metabolic Disease, 41(3), 475-490.

Halter, C., & Sunderkötter, C. (2018). Maroteaux-Lamy syndrome: A rare and overlooked genetic disorder. Journal of Inherited Metabolic Disease, 41(3), 509-517.

HIV (human immunodeficiency virus) infection is a condition in which the body is infected with HIV, a type of retrovirus that attacks the body's immune system. HIV infection can lead to AIDS (acquired immunodeficiency syndrome), a condition in which the immune system is severely damaged and the body is unable to fight off infections and diseases.

There are several ways that HIV can be transmitted, including:

1. Sexual contact with an infected person
2. Sharing of needles or other drug paraphernalia with an infected person
3. Mother-to-child transmission during pregnancy, childbirth, or breastfeeding
4. Blood transfusions ( although this is rare in developed countries due to screening processes)
5. Organ transplantation (again, rare)

The symptoms of HIV infection can be mild at first and may not appear until several years after infection. These symptoms can include:

1. Fever
2. Fatigue
3. Swollen glands in the neck, armpits, and groin
4. Rash
5. Muscle aches and joint pain
6. Night sweats
7. Diarrhea
8. Weight loss

If left untreated, HIV infection can progress to AIDS, which is a life-threatening condition that can cause a wide range of symptoms, including:

1. Opportunistic infections (such as pneumocystis pneumonia)
2. Cancer (such as Kaposi's sarcoma)
3. Wasting syndrome
4. Neurological problems (such as dementia and seizures)

HIV infection is diagnosed through a combination of blood tests and physical examination. Treatment typically involves antiretroviral therapy (ART), which is a combination of medications that work together to suppress the virus and slow the progression of the disease.

Prevention methods for HIV infection include:

1. Safe sex practices, such as using condoms and dental dams
2. Avoiding sharing needles or other drug-injecting equipment
3. Avoiding mother-to-child transmission during pregnancy, childbirth, or breastfeeding
4. Post-exposure prophylaxis (PEP), which is a short-term treatment that can prevent infection after potential exposure to the virus
5. Pre-exposure prophylaxis (PrEP), which is a daily medication that can prevent infection in people who are at high risk of being exposed to the virus.

It's important to note that HIV infection is manageable with proper treatment and care, and that people living with HIV can lead long and healthy lives. However, it's important to be aware of the risks and take steps to prevent transmission.

The term "anencephaly" comes from the Greek words "ane" meaning "without" and "encephalos" meaning "brain". It was first described by German anatomist Wilhelm His in 1879.

Anencephaly occurs when the neural tube, which is the precursor to the brain and spinal cord, fails to properly close during embryonic development. This can be due to a variety of factors, including genetic mutations, environmental exposures, or unknown causes.

The symptoms of anencephaly are severe and typically include:

* Absence of a major portion of the brain, skull, and scalp
* Enlarged ventricles in the brain
* Missing or underdeveloped facial features, such as eyes, nose, and mouth
* Underdeveloped brain stem and cerebellum
* Spina bifida, a condition in which the spine does not properly close during development

There is no treatment for anencephaly, and the condition is usually diagnosed prenatally through ultrasound examination. In some cases, the condition may be detected after birth, but the prognosis is always poor.

The prevalence of anencephaly is difficult to determine due to its rarity, but it is estimated to occur in approximately 1 in every 10,000 births. It is more common in males than females and may be associated with other congenital anomalies, such as heart defects or gastrointestinal abnormalities.

Overall, anencephaly is a severe and tragic condition that results in stillbirth or early death. While the exact cause is unknown, it is thought to be due to a combination of genetic and environmental factors during embryonic development.

Examples of autoimmune diseases include:

1. Rheumatoid arthritis (RA): A condition where the immune system attacks the joints, leading to inflammation, pain, and joint damage.
2. Lupus: A condition where the immune system attacks various body parts, including the skin, joints, and organs.
3. Hashimoto's thyroiditis: A condition where the immune system attacks the thyroid gland, leading to hypothyroidism.
4. Multiple sclerosis (MS): A condition where the immune system attacks the protective covering of nerve fibers in the central nervous system, leading to communication problems between the brain and the rest of the body.
5. Type 1 diabetes: A condition where the immune system attacks the insulin-producing cells in the pancreas, leading to high blood sugar levels.
6. Guillain-Barré syndrome: A condition where the immune system attacks the nerves, leading to muscle weakness and paralysis.
7. Psoriasis: A condition where the immune system attacks the skin, leading to red, scaly patches.
8. Crohn's disease and ulcerative colitis: Conditions where the immune system attacks the digestive tract, leading to inflammation and damage to the gut.
9. Sjögren's syndrome: A condition where the immune system attacks the glands that produce tears and saliva, leading to dry eyes and mouth.
10. Vasculitis: A condition where the immune system attacks the blood vessels, leading to inflammation and damage to the blood vessels.

The symptoms of autoimmune diseases vary depending on the specific disease and the organs or tissues affected. Common symptoms include fatigue, fever, joint pain, skin rashes, and swollen lymph nodes. Treatment for autoimmune diseases typically involves medication to suppress the immune system and reduce inflammation, as well as lifestyle changes such as dietary changes and stress management techniques.

1. Common cold: A viral infection that affects the upper respiratory tract and causes symptoms such as sneezing, running nose, coughing, and mild fever.
2. Influenza (flu): A viral infection that can cause severe respiratory illness, including pneumonia, bronchitis, and sinus and ear infections.
3. Measles: A highly contagious viral infection that causes fever, rashes, coughing, and redness of the eyes.
4. Rubella (German measles): A mild viral infection that can cause fever, rashes, headache, and swollen lymph nodes.
5. Chickenpox: A highly contagious viral infection that causes fever, itching, and a characteristic rash of small blisters on the skin.
6. Herpes simplex virus (HSV): A viral infection that can cause genital herpes, cold sores, or other skin lesions.
7. Human immunodeficiency virus (HIV): A viral infection that attacks the immune system and can lead to acquired immunodeficiency syndrome (AIDS).
8. Hepatitis B: A viral infection that affects the liver, causing inflammation and damage to liver cells.
9. Hepatitis C: Another viral infection that affects the liver, often leading to chronic liver disease and liver cancer.
10. Ebola: A deadly viral infection that causes fever, vomiting, diarrhea, and internal bleeding.
11. SARS (severe acute respiratory syndrome): A viral infection that can cause severe respiratory illness, including pneumonia and respiratory failure.
12. West Nile virus: A viral infection that can cause fever, headache, and muscle pain, as well as more severe symptoms such as meningitis or encephalitis.

Viral infections can be spread through contact with an infected person or contaminated surfaces, objects, or insects such as mosquitoes. Prevention strategies include:

1. Practicing good hygiene, such as washing hands frequently and thoroughly.
2. Avoiding close contact with people who are sick.
3. Covering the mouth and nose when coughing or sneezing.
4. Avoiding sharing personal items such as towels or utensils.
5. Using condoms or other barrier methods during sexual activity.
6. Getting vaccinated against certain viral infections, such as HPV and hepatitis B.
7. Using insect repellents to prevent mosquito bites.
8. Screening blood products and organs for certain viruses before transfusion or transplantation.

Treatment for viral infections depends on the specific virus and the severity of the illness. Antiviral medications may be used to reduce the replication of the virus and alleviate symptoms. In severe cases, hospitalization may be necessary to provide supportive care such as intravenous fluids, oxygen therapy, or mechanical ventilation.

Prevention is key in avoiding viral infections, so taking the necessary precautions and practicing good hygiene can go a long way in protecting oneself and others from these common and potentially debilitating illnesses.

Myoclonus can be classified into several types based on its duration, frequency, and distribution. Some common types of myoclonus include:

1. Generalized myoclonus: This type affects the entire body and is often seen in conditions such as epilepsy, encephalitis, and multiple sclerosis.
2. Localized myoclonus: This type affects a specific area of the body, such as the arm or leg.
3. Progressive myoclonus: This type worsens over time and is often seen in conditions such as Parkinson's disease and Huntington's disease.
4. Periodic myoclonus: This type is characterized by recurring episodes of muscle contractions and releases, often triggered by specific stimuli such as noise or stress.
5. Task-specific myoclonus: This type is seen in individuals who perform repetitive tasks, such as typing or using a computer mouse.

Myoclonus can cause a range of symptoms, including muscle weakness, fatigue, and difficulty with coordination and balance. In some cases, myoclonus can also lead to falls or injuries. Treatment for myoclonus depends on the underlying cause and may include medications such as anticonvulsants, physical therapy, and lifestyle modifications.

Myoclonus is a relatively rare condition, but it can have a significant impact on an individual's quality of life. It can affect their ability to perform daily activities, participate in social events, and maintain their independence. If you or someone you know has been diagnosed with myoclonus, it is important to work closely with a healthcare provider to develop a personalized treatment plan and manage the condition effectively.

The three main subtypes of FASD are:

1. Fetal Alcohol Syndrome (FAS): This is the most severe form of FASD and is characterized by a combination of physical, behavioral, and cognitive abnormalities. Individuals with FAS often have facial abnormalities, growth retardation, and central nervous system defects.
2. Partial Fetal Alcohol Syndrome (pFAS): This subtype is characterized by some, but not all, of the physical and behavioral characteristics of FAS.
3. Alcohol-Related Birth Defects (ARBD): This subtype includes individuals who have physical birth defects caused by prenatal alcohol exposure, but do not meet the full criteria for FAS or pFAS.

Other types of FASD include:

1. Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): This subtype is characterized by behavioral and cognitive abnormalities, such as attention deficit hyperactivity disorder (ADHD), anxiety, and depression.
2. Maternal and Child Health Consensus Statement on FASD: This subtype includes individuals who have a history of prenatal alcohol exposure and exhibit a range of physical, behavioral, and cognitive abnormalities, but do not meet the full criteria for any of the other subtypes.

The diagnosis of FASD is based on a combination of clinical findings, medical history, and developmental assessments. There is no specific test or biomarker for FASD, so diagnosis can be challenging and requires expertise in pediatrics, neurology, and developmental psychopathology.

Treatment for FASD typically involves a multidisciplinary approach that includes medical care, behavioral interventions, and supportive services. Management of the condition may involve working with a team of healthcare professionals, such as pediatricians, neurologists, developmental specialists, and social workers.

The prognosis for individuals with FASD varies depending on the severity of their alcohol exposure during pregnancy, the timing and amount of exposure, and the presence of any comorbid conditions. However, early diagnosis and intervention can significantly improve outcomes and reduce the risk of long-term complications.

In summary, FASD is a complex and multifactorial condition that results from alcohol exposure during pregnancy. Diagnosis can be challenging, but a comprehensive evaluation and multidisciplinary approach to treatment can improve outcomes for individuals with FASD.

The symptoms of cerebral ventricle neoplasms depend on their size, location, and growth rate. They may include headaches, seizures, weakness or numbness in the arms or legs, and changes in personality or cognitive function. As the tumor grows, it can press on surrounding brain tissue and disrupt normal brain function.

Diagnosis of cerebral ventricle neoplasms typically involves a combination of imaging studies such as CT or MRI scans, and tissue sampling through a biopsy procedure. Treatment options for cerebral ventricle neoplasms depend on the type and location of the tumor, as well as the patient's overall health status. Surgery, radiation therapy, and chemotherapy may be used alone or in combination to treat these tumors.

Examples of types of cerebral ventricle neoplasms include:

1. Choroid plexus papilloma: A benign tumor that arises from the choroid plexus, a layer of tissue that lines the ventricles and produces cerebrospinal fluid.
2. Choroid plexus carcinoma: A malignant tumor that arises from the choroid plexus.
3. Ventricular ependymoma: A tumor that arises from the ependyma, a layer of tissue that lines the ventricles and helps to move cerebrospinal fluid through the brain.
4. Subependymal giant cell astrocytoma (SEGA): A rare benign tumor that arises from the subependymal layer of tissue, which is located beneath the ependyma.

Overall, cerebral ventricle neoplasms are a complex and diverse group of brain tumors that can have significant impacts on the brain and nervous system. Treatment options vary depending on the specific type of tumor and the individual patient's needs.

Examples of abnormal reflexes include:

1. Overactive reflexes: Reflexes that are too strong or exaggerated, such as an oversensitive knee jerk reflex.
2. Underactive reflexes: Reflexes that are too weak or diminished, such as a decreased tendon reflex in the arm.
3. Delayed reflexes: Reflexes that take longer than expected to occur, such as a delayed deep tendon reflex.
4. Abnormal reflex arc: A reflex arc that is not normal or expected for the situation, such as a spastic reflex arc.
5. Reflexes that are out of proportion to the stimulus: Such as an excessive or exaggerated reflex response to a mild stimulus.
6. Reflexes that occur in the absence of a stimulus: Such as a spontaneous reflex.
7. Reflexes that do not resolve: Such as a persistent reflex.
8. Reflexes that are painful or uncomfortable: Such as an abnormal rectal reflex.

It's important to note that not all abnormal reflexes are necessarily indicative of a serious medical condition, but they should be evaluated by a healthcare professional to determine the underlying cause and appropriate treatment.

The symptoms of meningeal carcinomatosis can vary depending on the location and extent of the tumor, but may include headaches, seizures, weakness or numbness in the arms or legs, and changes in personality or mental status. The diagnosis is typically made by a combination of physical examination, imaging studies such as CT or MRI scans, and laboratory tests to detect the presence of cancer cells in the cerebrospinal fluid (CSF).

Treatment of meningeal carcinomatosis depends on the underlying cause and the extent of the tumor. Treatment options may include surgery, radiation therapy, and chemotherapy, as well as supportive care to manage symptoms such as pain, seizures, and infection. The prognosis for meningeal carcinomatosis is generally poor, with a five-year survival rate of less than 10%.

Types of Optic Nerve Injuries:

1. Traumatic optic neuropathy: This type of injury is caused by direct damage to the optic nerve as a result of trauma, such as a car accident or sports injury.
2. Ischemic optic neuropathy: This type of injury is caused by a lack of blood flow to the optic nerve, which can lead to cell death and vision loss.
3. Inflammatory optic neuropathy: This type of injury is caused by inflammation of the optic nerve, which can be caused by conditions such as multiple sclerosis or sarcoidosis.
4. Tumor-induced optic neuropathy: This type of injury is caused by a tumor that compresses or damages the optic nerve.
5. Congenital optic nerve disorders: These are present at birth and can cause vision loss or blindness. Examples include optic nerve hypoplasia and coloboma.

Symptoms of Optic Nerve Injuries:

* Blurred vision or double vision
* Loss of peripheral vision
* Difficulty seeing in dim lighting
* Pain or discomfort in the eye or head
* Redness or swelling of the eye

Diagnosis and Treatment of Optic Nerve Injuries:

Diagnosis is typically made through a combination of physical examination, imaging tests such as MRI or CT scans, and visual field testing. Treatment depends on the underlying cause of the injury, but may include medication, surgery, or vision rehabilitation. In some cases, vision loss may be permanent, but early diagnosis and treatment can help to minimize the extent of the damage.

Prognosis for Optic Nerve Injuries:

The prognosis for optic nerve injuries varies depending on the underlying cause and severity of the injury. In some cases, vision may be partially or fully restored with treatment. However, in other cases, vision loss may be permanent. It is important to seek medical attention immediately if any symptoms of an optic nerve injury are present, as early diagnosis and treatment can improve outcomes.

Alphaviruses are a group of viruses that cause a range of diseases, including arthritis, encephalitis, and fever. These viruses are typically found in tropical and subtropical regions of the world and are transmitted to humans through the bite of infected mosquitoes or other insects.

There are several different types of alphaviruses, including:

* Chikungunya virus (CHIKV)
* Sindbis virus (SINV)
* Ross River virus (RRV)
* Barmah Forest virus (BFV)

The symptoms of alphavirus infections can vary depending on the specific type of virus and the severity of the infection. Common symptoms include:

* Fever
* Headache
* Muscle and joint pain
* Swelling and inflammation
* Rash
* Fatigue
* Weakness

In some cases, alphavirus infections can lead to more serious complications, such as meningitis or encephalitis (inflammation of the brain). These complications are more likely to occur in older adults or people with weakened immune systems.

There is no specific treatment for alphavirus infections, but symptoms can be managed with over-the-counter pain relievers, fever reducers, and anti-inflammatory medications. Rest, hydration, and supportive care may also be recommended. Prevention is key to avoiding alphavirus infections, and this includes protecting against mosquito bites by using insect repellents, wearing protective clothing, and staying in air-conditioned or screened areas. Vaccines are also being developed to protect against some of the most common types of alphaviruses.

The symptoms of AIDS can vary depending on the individual and the stage of the disease. Common symptoms include:

1. Fever
2. Fatigue
3. Swollen glands
4. Rash
5. Muscle aches and joint pain
6. Night sweats
7. Diarrhea
8. Weight loss
9. Memory loss and other neurological problems
10. Cancer and other opportunistic infections.

AIDS is diagnosed through blood tests that detect the presence of HIV antibodies or the virus itself. There is no cure for AIDS, but antiretroviral therapy (ART) can help manage the symptoms and slow the progression of the disease. Prevention methods include using condoms, pre-exposure prophylaxis (PrEP), and avoiding sharing needles or other injection equipment.

In summary, Acquired Immunodeficiency Syndrome (AIDS) is a severe and life-threatening condition caused by the Human Immunodeficiency Virus (HIV). It is characterized by a severely weakened immune system, which makes it difficult to fight off infections and diseases. While there is no cure for AIDS, antiretroviral therapy can help manage the symptoms and slow the progression of the disease. Prevention methods include using condoms, pre-exposure prophylaxis, and avoiding sharing needles or other injection equipment.

Symptoms of BSE include:

* Behavioral changes, such as aggression or confusion
* Loss of coordination and balance
* Weakness or paralysis of the limbs
* Vision problems
* Difficulty swallowing or chewing
* Change in vocalization or bellowing

BSE is transmitted through the consumption of contaminated beef products, such as meat and bonemeal, which contain the abnormal prion protein. The disease can also be spread through blood transfusions or other medical procedures using infected material.

There is no cure for BSE, and it is typically diagnosed through a combination of clinical signs, necropsy, and laboratory tests such as the polymerase chain reaction (PCR) or Western blotting.

Prevention of BSE includes:

* Implementing strict controls on the handling and disposal of animal carcasses and tissues
* Avoiding the use of meat and bonemeal in animal feed
* Ensuring proper sterilization and safety protocols in medical procedures
* Monitoring and testing for the presence of the disease in cattle populations.

BSE has significant economic and public health implications, as it can lead to the loss of entire herds and the closure of livestock markets, as well as the potential for human transmission through the consumption of contaminated beef products.

ALS is caused by a breakdown of the nerve cells responsible for controlling voluntary muscle movement, leading to muscle atrophy and loss of motor function. The disease can affect anyone, regardless of age or gender, but it is most common in people between the ages of 55 and 75.

The symptoms of ALS can vary from person to person, but they typically include:

* Muscle weakness or twitching
* Muscle wasting or atrophy
* Loss of motor function, such as difficulty walking, speaking, or swallowing
* Slurred speech or difficulty with language processing
* Weakness or paralysis of the limbs
* Difficulty with balance and coordination
* Fatigue and weakness
* Cognitive changes, such as memory loss and decision-making difficulties

There is currently no cure for ALS, but there are several treatments available to help manage the symptoms and slow the progression of the disease. These include:

* Riluzole, a medication that reduces the amount of glutamate in the brain, which can slow down the progression of ALS
* Physical therapy, to maintain muscle strength and function as long as possible
* Occupational therapy, to help with daily activities and assistive devices
* Speech therapy, to improve communication and swallowing difficulties
* Respiratory therapy, to manage breathing problems
* Nutritional support, to ensure adequate nutrition and hydration

The progression of ALS can vary greatly from person to person, but on average, people with the disease live for 2-5 years after diagnosis. However, some people may live for up to 10 years or more with the disease. The disease is usually diagnosed through a combination of medical history, physical examination, and diagnostic tests such as electromyography (EMG) and magnetic resonance imaging (MRI).

There is ongoing research into the causes of ALS and potential treatments for the disease. Some promising areas of research include:

* Gene therapy, to repair or replace the faulty genes that cause ALS
* Stem cell therapy, to promote the growth of healthy cells in the body
* Electrical stimulation, to improve muscle function and strength
* New medications, such as antioxidants and anti-inflammatory drugs, to slow down the progression of ALS

Overall, while there is currently no cure for ALS, there are several treatments available to help manage the symptoms and slow the progression of the disease. Ongoing research offers hope for new and more effective treatments in the future.

The fungus is found in soil and water and is typically contracted through the inhalation of contaminated dust or the ingestion of contaminated food or water. The symptoms of blastomycosis can vary depending on the severity of the infection, but may include:

* Fever
* Cough
* Shortness of breath
* Skin lesions
* Joint pain
* Swollen lymph nodes

In severe cases, blastomycosis can lead to life-threatening complications such as respiratory failure, cardiovascular problems, and meningitis.

Diagnosis of blastomycosis is based on a combination of clinical findings, laboratory tests, and imaging studies. Treatment typically involves antifungal medications, which can be effective in resolving symptoms and preventing complications. However, the disease can be challenging to diagnose and treat, and long-term follow-up is often necessary to ensure that the infection has been fully cleared.

Preventive measures for blastomycosis include avoiding contact with contaminated soil and water, wearing protective clothing and equipment when working outdoors in areas where the fungus is prevalent, and taking antifungal medications as prescribed by a healthcare provider. Early diagnosis and treatment are critical to preventing severe complications and improving outcomes for patients with blastomycosis.

White blood cells are an important part of the immune system and play a crucial role in fighting off infections and diseases. However, when there is an excessive increase in their numbers, it can lead to various complications, including:

1. Increased risk of infection: With too many white blood cells in the bloodstream, there is a higher chance of developing infections.
2. Inflammation: Excessive production of white blood cells can cause inflammation in various parts of the body.
3. Blood clotting disorders: White blood cells can clump together and form clots, which can lead to blockages in blood vessels.
4. Tissue damage: The excessive growth of white blood cells can cause damage to tissues and organs.
5. Bone marrow failure: Prolonged leukocytosis can lead to bone marrow failure, which can result in a decrease in the production of other blood cells, such as red blood cells and platelets.

There are several types of leukocytosis, including:

1. Reactive leukocytosis: This is the most common type and is caused by an infection or inflammation.
2. Chronic leukocytosis: This type is characterized by a persistent increase in white blood cells over a long period of time.
3. Acute leukocytosis: This type is characterized by a sudden and severe increase in white blood cells, often accompanied by other symptoms such as fever and fatigue.
4. Leukemia: This is a type of cancer that affects the bone marrow and blood cells. It can cause an abnormal increase in white blood cells.

Diagnosis of leukocytosis typically involves a physical examination, medical history, and laboratory tests such as complete blood count (CBC) and bone marrow biopsy. Treatment depends on the underlying cause and may include antibiotics for infections, steroids to reduce inflammation, or chemotherapy for leukemia. In some cases, no treatment is necessary if the condition resolves on its own.

Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1% of the population over the age of 60. It is more common in men than women and has a higher incidence in Caucasians than in other ethnic groups.

The primary symptoms of Parkinson's disease are:

* Tremors or trembling, typically starting on one side of the body
* Rigidity or stiffness, causing difficulty with movement
* Bradykinesia or slowness of movement, including a decrease in spontaneous movements such as blinking or smiling
* Postural instability, leading to falls or difficulty with balance

As the disease progresses, symptoms can include:

* Difficulty with walking, gait changes, and freezing episodes
* Dry mouth, constipation, and other non-motor symptoms
* Cognitive changes, such as dementia, memory loss, and confusion
* Sleep disturbances, including REM sleep behavior disorder
* Depression, anxiety, and other psychiatric symptoms

The exact cause of Parkinson's disease is not known, but it is believed to involve a combination of genetic and environmental factors. The disease is associated with the degradation of dopamine-producing neurons in the substantia nigra, leading to a deficiency of dopamine in the brain. This deficiency disrupts the normal functioning of the basal ganglia, a group of structures involved in movement control, leading to the characteristic symptoms of the disease.

There is no cure for Parkinson's disease, but various treatments are available to manage its symptoms. These include:

* Medications such as dopaminergic agents (e.g., levodopa) and dopamine agonists to replace lost dopamine and improve motor function
* Deep brain stimulation, a surgical procedure that involves implanting an electrode in the brain to deliver electrical impulses to specific areas of the brain
* Physical therapy to improve mobility and balance
* Speech therapy to improve communication and swallowing difficulties
* Occupational therapy to improve daily functioning

It is important for individuals with Parkinson's disease to work closely with their healthcare team to develop a personalized treatment plan that addresses their specific needs and improves their quality of life. With appropriate treatment and support, many people with Parkinson's disease are able to manage their symptoms and maintain a good level of independence for several years after diagnosis.

Symptoms of hydranencephaly can vary depending on the severity of the condition, but may include developmental delays, intellectual disability, seizures, and difficulty with coordination and balance. Treatment for hydranencephaly is limited and primarily focuses on managing associated symptoms and providing supportive care to affected individuals. Surgery may be considered in some cases to relieve pressure on the brain or to remove cysts that are causing symptoms.

Prognosis for hydranencephaly varies depending on the severity of the condition and the presence of any additional congenital anomalies. In general, the prognosis is poor for individuals with hydranencephaly, and many do not survive beyond infancy or childhood. However, some individuals with milder forms of the condition may have a better outcome, and may be able to lead relatively normal lives with appropriate support and management.

Tonic movement:

* Stiffening or rigidity of muscles
* Loss of postural control

Clonic movement:

* Jerky movements of the arms, legs, or entire body
* Involuntary contractions

During a tonic-clonic seizure, the person may experience a variety of symptoms, including:

* Sudden loss of consciousness
* Confusion and disorientation after regaining consciousness
* Memory loss for the event
* Weakness or fatigue
* Headache
* Nausea and vomiting

Tonic-clonic seizures can be caused by a variety of factors, including:

* Genetic mutations that affect brain function
* Infections such as meningitis or encephalitis
* Traumatic head injury
* Stroke or bleeding in the brain
* Brain tumors or cysts
* Drug and alcohol withdrawal
* Electrolyte imbalances

There are several different types of tonic-clonic seizures, including:

* Simple partial seizures: These are less severe than tonic-clonic seizures and may involve only one part of the body.
* Complex partial seizures: These are more severe than simple partial seizures and can involve both sides of the body.
* Tonic-clonic seizures with secondary generalization: This type of seizure starts as a simple or complex partial seizure and then spreads to other parts of the body.

Treatment for tonic-clonic seizures typically involves medication, such as anticonvulsants, which can help reduce the frequency and severity of seizures. In some cases, surgery may be necessary to remove a brain tumor or cyst that is causing the seizures.

Overall, tonic-clonic seizures are a serious medical condition that can have significant consequences if not properly treated. If you experience a seizure, it is important to seek medical attention as soon as possible to determine the cause and receive appropriate treatment.

There are many different causes of polyneuropathy, including:

1. Diabetes: High blood sugar levels over time can damage nerves, leading to numbness, tingling, and pain in the hands and feet.
2. Vitamin deficiencies: Deficiencies in vitamins such as B12 and B6 can cause nerve damage and polyneuropathy.
3. Toxins: Exposure to certain toxins, such as heavy metals or pesticides, can damage nerves and cause polyneuropathy.
4. Infections: Certain infections, such as Lyme disease and HIV, can cause polyneuropathy.
5. Autoimmune disorders: Conditions such as Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy (CIDP) are autoimmune disorders that can cause polyneuropathy.
6. Trauma: Physical trauma, such as a severe injury or crush injury, can cause polyneuropathy.
7. Cancer: Certain types of cancer, such as lymphoma and leukemia, can cause polyneuropathy.
8. Genetic disorders: Some inherited conditions, such as Charcot-Marie-Tooth disease, can cause polyneuropathy.

The symptoms of polyneuropathy depend on the specific nerves affected and can include:

1. Numbness or tingling in the hands and feet
2. Pain in the hands and feet
3. Weakness in the muscles of the hands and feet
4. Difficulty walking or maintaining balance
5. Loss of reflexes
6. Sensitivity to touch or temperature changes
7. Muscle wasting
8. Decreased dexterity
9. Tremors
10. Autonomic dysfunction (e.g., bowel or bladder problems)

The diagnosis of polyneuropathy is based on a combination of clinical findings, nerve conduction studies, and laboratory tests. Treatment depends on the underlying cause of the condition and may include:

1. Pain management with medications such as pain relievers or anti-seizure drugs
2. Physical therapy to maintain muscle strength and mobility
3. Occupational therapy to improve daily functioning
4. Assistive devices, such as canes or walkers, to aid with mobility
5. Autonomic dysfunction management with medications such as beta blockers or fludrocortisone
6. Plasmapheresis, a procedure that removes harmful antibodies from the blood
7. Immunoglobulin therapy, which can help to reduce inflammation
8. Intravenous immunoglobulin (IVIG) therapy, which can help to reduce inflammation and repair nerve damage
9. Dietary changes, such as increasing protein intake, to support nerve health
10. Avoiding harmful substances, such as alcohol or tobacco, which can worsen the condition.

Delirium is a sudden change in mental status that can be caused by a variety of factors such as infection, medication, or surgery. It is characterized by confusion, disorientation, and a decreased level of consciousness. Dementia, on the other hand, is a gradual decline in mental abilities that can be caused by various underlying diseases such as Alzheimer's disease, vascular dementia, or frontotemporal dementia.

Amnestic disorders refer specifically to conditions that affect memory, such as amnesia, which is the inability to form new memories. Cognitive disorders are more general term that includes a wide range of conditions that affect cognitive functions such as attention, perception, language, and problem-solving abilities.

These conditions can be caused by various factors such as genetics, head trauma, infections, or diseases such as stroke or brain tumors. Diagnosis is typically made through a combination of medical history, physical examination, laboratory tests, and neuropsychological evaluations.

Treatment for delirium, dementia, amnestic, and cognitive disorders can vary depending on the underlying cause but may include medication, therapy, and lifestyle changes. In some cases, these conditions may be reversible with appropriate treatment, while in others, they may be irreversible.

It is important to seek medical attention if symptoms persist or worsen over time as early diagnosis and intervention can improve outcomes for individuals with these conditions.

Cerebral infarction can result in a range of symptoms, including sudden weakness or numbness in the face, arm, or leg on one side of the body, difficulty speaking or understanding speech, sudden vision loss, dizziness, and confusion. Depending on the location and severity of the infarction, it can lead to long-term disability or even death.

There are several types of cerebral infarction, including:

1. Ischemic stroke: This is the most common type of cerebral infarction, accounting for around 87% of all cases. It occurs when a blood clot blocks the flow of blood to the brain, leading to cell death and tissue damage.
2. Hemorrhagic stroke: This type of cerebral infarction occurs when a blood vessel in the brain ruptures, leading to bleeding and cell death.
3. Lacunar infarction: This type of cerebral infarction affects the deep structures of the brain, particularly the basal ganglia, and is often caused by small blockages or stenosis (narrowing) in the blood vessels.
4. Territorial infarction: This type of cerebral infarction occurs when there is a complete blockage of a blood vessel that supplies a specific area of the brain, leading to cell death and tissue damage in that area.

Diagnosis of cerebral infarction typically involves a combination of physical examination, medical history, and imaging tests such as CT or MRI scans. Treatment options vary depending on the cause and location of the infarction, but may include medication to dissolve blood clots, surgery to remove blockages, or supportive care to manage symptoms and prevent complications.

Some common causes of confusion in the medical field include:

1. Medication side effects: Certain medications can cause confusion as a side effect, particularly those that affect the central nervous system, such as sedatives, anti-anxiety drugs, and painkillers.
2. Delirium: A sudden and severe confusional state that can be caused by various factors, such as infections, surgery, or alcohol or drug withdrawal.
3. Dementia: A progressive decline in cognitive function that can cause confusion, memory loss, and difficulty with communication and daily activities. Alzheimer's disease is the most common cause of dementia.
4. Traumatic brain injury: A head injury that can cause confusion, memory loss, and other cognitive difficulties.
5. Stroke: A loss of blood flow to the brain that can cause confusion, weakness, and difficulty with speech and mobility.
6. Infections: Certain infections, such as urinary tract infections or sepsis, can cause confusion and disorientation.
7. Sleep disorders: Sleep disturbances, such as insomnia or sleep apnea, can lead to confusion and other cognitive difficulties.
8. Chronic conditions: Certain chronic conditions, such as diabetes, hypertension, or hypothyroidism, can cause confusion if left untreated or poorly managed.
9. Nutritional deficiencies: Deficiencies in certain nutrients, such as vitamin B12 or thiamine, can cause confusion and other cognitive difficulties.
10. Substance abuse: Withdrawal from drugs or alcohol can cause confusion, agitation, and other cognitive difficulties.

In the medical field, confusion is often evaluated through a series of questions and physical examinations to determine its underlying cause. Treatment may involve addressing any underlying conditions, managing symptoms, and providing supportive care to help improve cognitive function. In some cases, medication or other interventions may be necessary to manage symptoms and improve quality of life.

1. Centers for Disease Control and Prevention (CDC). (2022). Encephalitis. Retrieved from
2. Mayo Clinic. (2022). Encephalitis. Retrieved from
3. MedlinePlus. (2022). Encephalitis. Retrieved from
4. UC Davis Health System. (2022). Encephalitis. Retrieved from
5. California Department of Public Health. (2022). Encephalitis. Retrieved from

In the medical field, "Encephalitis, California" refers to a type of inflammatory disease that affects the brain and is caused by a viral or bacterial infection. The term specifically refers to cases of encephalitis that occur in the state of California.

Encephalitis is a serious condition that can cause a range of symptoms, including fever, headache, confusion, seizures, and loss of consciousness. In severe cases, it can lead to long-term complications, such as brain damage, or even be fatal.

The causes of encephalitis in California are typically viral or bacterial infections that are transmitted through mosquitoes, ticks, or other vectors. The most common viruses that cause encephalitis in the state include West Nile virus, Japanese encephalitis virus, and St. Louis encephalitis virus.

The diagnosis of encephalitis is typically made based on a combination of clinical symptoms, laboratory tests, and imaging studies such as CT or MRI scans. Treatment for encephalitis typically involves supportive care, such as intravenous fluids, oxygen therapy, and medication to manage fever and pain. In severe cases, antiviral or antibacterial medications may be administered to help reduce the severity of the infection.

Prevention of encephalitis in California is focused on reducing the risk of mosquito-borne and tick-borne infections. This includes using insect repellents, wearing protective clothing, and avoiding areas with high mosquito or tick activity. Vaccines are also available for some of the viruses that cause encephalitis, such as West Nile virus.

In summary, "Encephalitis, California" refers to a serious inflammatory disease that affects the brain and is caused by viral or bacterial infections in the state of California. The diagnosis and treatment of encephalitis are based on clinical symptoms and laboratory tests, and prevention strategies focus on reducing the risk of mosquito-borne and tick-borne infections.

Prenatal Exposure Delayed Effects can affect various aspects of the child's development, including:

1. Physical growth and development: PDEDs can lead to changes in the child's physical growth patterns, such as reduced birth weight, short stature, or delayed puberty.
2. Brain development: Prenatal exposure to certain substances can affect brain development, leading to learning disabilities, memory problems, and cognitive delays.
3. Behavioral and emotional development: Children exposed to PDEDs may exhibit behavioral and emotional difficulties, such as anxiety, depression, or attention deficit hyperactivity disorder (ADHD).
4. Immune system functioning: Prenatal exposure to certain substances can affect the immune system's development, making children more susceptible to infections and autoimmune diseases.
5. Reproductive health: Exposure to certain chemicals during fetal development may disrupt the reproductive system, leading to fertility problems or an increased risk of infertility later in life.

The diagnosis of Prenatal Exposure Delayed Effects often requires a comprehensive medical history and physical examination, as well as specialized tests such as imaging studies or laboratory assessments. Treatment for PDEDs typically involves addressing the underlying cause of exposure and providing appropriate interventions to manage any associated symptoms or developmental delays.

In summary, Prenatal Exposure Delayed Effects can have a profound impact on a child's growth, development, and overall health later in life. It is essential for healthcare providers to be aware of the potential risks and to monitor children exposed to substances during fetal development for any signs of PDEDs. With early diagnosis and appropriate interventions, it may be possible to mitigate or prevent some of these effects and improve outcomes for affected children.

The term "systemic" refers to the fact that the disease affects multiple organ systems, including the skin, joints, kidneys, lungs, and nervous system. LES is a complex condition, and its symptoms can vary widely depending on which organs are affected. Common symptoms include fatigue, fever, joint pain, rashes, and swelling in the extremities.

There are several subtypes of LES, including:

1. Systemic lupus erythematosus (SLE): This is the most common form of the disease, and it can affect anyone, regardless of age or gender.
2. Discoid lupus erythematosus (DLE): This subtype typically affects the skin, causing a red, scaly rash that does not go away.
3. Drug-induced lupus erythematosus: This form of the disease is caused by certain medications, and it usually resolves once the medication is stopped.
4. Neonatal lupus erythematosus: This rare condition affects newborn babies of mothers with SLE, and it can cause liver and heart problems.

There is no cure for LES, but treatment options are available to manage the symptoms and prevent flares. Treatment may include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, immunosuppressive medications, and antimalarial drugs. In severe cases, hospitalization may be necessary to monitor and treat the disease.

It is important for people with LES to work closely with their healthcare providers to manage their condition and prevent complications. With proper treatment and self-care, many people with LES can lead active and fulfilling lives.

1. Difficulty regulating body temperature, leading to episodes of hyperthermia (elevated body temperature) or hypothermia (low body temperature).
2. Abnormal heart rate and rhythm, including bradycardia (slow heart rate) or tachycardia (fast heart rate).
3. Poor digestion and gastrointestinal problems such as constipation, diarrhea, nausea, and vomiting.
4. Difficulty swallowing, which can lead to respiratory problems.
5. Orthostatic intolerance, which can cause dizziness, lightheadedness, or fainting when standing up.
6. Seizures and other neurological symptoms such as tremors, muscle weakness, and loss of coordination.
7. Cognitive impairment, including developmental delays, intellectual disability, and learning disabilities.
8. Sleep disturbances, including insomnia and sleep apnea.
9. Emotional difficulties such as anxiety, depression, and mood swings.
10. Vision problems, including blurred vision, double vision, and light sensitivity.

Primary dysautonomias are caused by genetic mutations that affect the development or function of the autonomic nervous system. There are several subtypes of primary dysautonomias, each with distinct symptoms and characteristics. These conditions are rare and can be difficult to diagnose, as they often resemble other more common conditions such as anxiety disorders or attention deficit hyperactivity disorder (ADHD). Treatment for primary dysautonomias typically involves a combination of medication and lifestyle modifications, such as reducing stress, increasing fluid intake, and avoiding overexertion. In some cases, surgery may be necessary to correct anatomical abnormalities or to implant medical devices that help regulate the autonomic nervous system.



Anorexia can have serious physical and emotional consequences, including:

* Malnutrition and nutrient deficiencies
* Osteoporosis and bone loss
* Heart problems and low blood pressure
* Hormonal imbalances
* Depression, anxiety, and other mood disorders
* Social isolation and difficulties in relationships

There are two main types of anorexia:

* Restrictive type: Characterized by restrictive eating habits and a fear of gaining weight.
* Binge/purge type: Characterized by episodes of binge eating followed by purging behaviors, such as vomiting or using laxatives.

Treatment for anorexia typically involves a combination of psychotherapy, nutrition counseling, and medication. Family-based therapy, cognitive-behavioral therapy, and interpersonal psychotherapy are some of the common approaches used to treat anorexia. Medications such as antidepressants and anti-anxiety drugs may also be prescribed to help manage symptoms.

In conclusion, anorexia is a complex and serious eating disorder that can have long-lasting physical and emotional consequences. It is important to seek professional help if symptoms persist or worsen over time. With appropriate treatment, individuals with anorexia can recover and lead a healthy and fulfilling life.

The exact cause of ganglioglioma is not fully understood, but genetic mutations and alterations have been implicated in its development. These tumors are more common in children than adults and can occur at any age.

Gangliogliomas can be diagnosed through a combination of clinical examination, imaging studies such as MRI or CT scans, and tissue biopsy. Treatment options for ganglioglioma depend on the size, location, and aggressiveness of the tumor. Surgery is often the first line of treatment, followed by radiation therapy if necessary.

Overall, ganglioglioma is a rare and relatively uncommon type of brain tumor that can be challenging to diagnose and treat. However, with advances in medical technology and research, the prognosis for patients with this condition is improving.

Wikimedia Commons has media related to Central nervous system. Overview of the Central Nervous System at the Wayback Machine ( ... The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS ... Lastly, cancers of the central nervous system can cause severe illness and, when malignant, can have very high mortality rates ... ISBN 978-0-07-139011-8. Huijzen, R. Nieuwenhuys, J. Voogd, C. van (2007). The human central nervous system (4th ed.). Berlin: ...
A central nervous system tumor (CNS tumor) is an abnormal growth of cells from the tissues of the brain or spinal cord. CNS ... "Adult Central Nervous System Tumors Treatment". National Cancer Institute. 1980-01-01. Retrieved 2019-06-28. "Tumor Types". ... "Adult Central Nervous System Tumors Treatment (PDQ®)-Patient Version". National Cancer Institute. 2019-10-11. Retrieved 2019-11 ... Frühwald, Michael C; Rutkowski, Stefan (2011). "Tumors of the Central Nervous System in Children and Adolescents". Deutsches ...
... s, also known as central nervous system disorders, are a group of neurological disorders that ... "Nervous System Diseases". Healthinsite.gov.au. Retrieved 2013-10-30. Central Nervous System Diseases at the US National Library ... Tumors of the central nervous system constitute around 2% of all cancer in the United States. Catalepsy is a nervous disorder ... Central nervous system tumors are the most common forms of pediatric cancer. Brain tumors are the most frequent and have the ...
... , or central fatigue, is a form of fatigue that is associated with changes in the synaptic ... In the central nervous system, acetylcholine modulates arousal and temperature regulation. It also may play a role in central ... Central nervous system effects of caffeine and adenosine on fatigue. J. Mark Davis, Zuowei Zhao, Howard S. Stock, Kristen A. ... Central nervous system fatigue alerts the athlete when physiological conditions are not optimal so either rest or refueling can ...
Central nervous system, Central nervous system disorders). ... Central nervous system depression can also be caused by the ... Central nervous system (CNS) depression is a physiological state that can result in a decreased rate of breathing, decreased ... Depression of the central nervous system is generally caused by the use of depressant drugs such as ethanol, opioids, ... Central nervous system depression caused by certain drugs may respond to treatment with an antidote.[citation needed] There are ...
A central nervous system cyst is a type of cyst that presents and affects part of the central nervous system (CNS). They are ... They normally take over the neuraxis, the axis of the central nervous system that determines how the nervous system is placed, ... Sundaram C, Paul T R, Raju B V, Ramakrishna Murthy T, Sinha A K, Prasad V S, Purohit A K. Cysts of the central nervous system ... If the cysts develop in critical areas of the central nervous system, they can present one or more of the following symptoms: ...
Cerebral cavernous malformation (CCM) is a cavernous hemangioma that arises in the central nervous system (CNS). It can be ... they are hooked into the venous side of the circulatory system), they will be angiographically occult (invisible). If a lesion ...
The Central Nervous System controls most of the functions of the body and mind. It comprises the brain, spinal cord and the ... The Central Nervous System viral diseases are caused by viruses that attack the CNS. Existing and emerging viral CNS infections ... "Viral Central Nervous System Infections in Children - Children's Health Issues - Merck Manuals Consumer Version". Merck Manuals ... Many viral infections of the central nervous system occur in seasonal peaks or as epidemics, whereas others, such as herpes ...
... (PCNSL), also termed primary diffuse large B-cell lymphoma of the central nervous ... Corn BW, Marcus SM, Topham A, Hauck W, Curran WJ (June 1997). "Will primary central nervous system lymphoma be the most ... Herrlinger U, Schabet M, Bitzer M, Petersen D, Krauseneck P (July 1999). "Primary central nervous system lymphoma: from ... Jellinger K, Radaskiewicz TH, Slowik F (1975). "Primary malignant lymphomas of the central nervous system in man". Acta ...
2014). "Tumors of the Central Nervous System, Volume 13". Tumors of the Central Nervous System. 13. doi:10.1007/978-94-007-7602 ... A central nervous system primitive neuroectodermal tumor, often abbreviated as PNET, supratentorial PNET, or CNS-PNET, is one ... Louis DN, Ohgaki H, Wiestler OD, Cavenee WK "WHO Classification of Tumours of the Central Nervous System. 4th Edition Revised" ... The differentiation between primitive neuroectodermal tumor in the central nervous system and medulloblastoma is recent. ...
Central nervous system, Central nervous system disorders). ... Spongy degeneration of the central nervous system, also known ... Adachi M (1967). "Studies on Spongy Degeneration of the Central Nervous System (Van Bogaert-Bertrand Type)". Inborn Disorders ... where the growth and maintenance of myelin sheath in the central nervous system (CNS) are impaired. There are three types of ... Gene Therapy of the Central Nervous System. pp. 303-316. doi:10.1016/B978-012397632-1/50024-1. ISBN 978-0-12-397632-1. ...
However, in a person with MS, these cells recognize healthy parts of the central nervous system as foreign and attack them as ... Multiple sclerosis and other demyelinating diseases of the central nervous system (CNS) produce lesions (demyelinated areas in ... "Demyelinating diseases of the central nervous system". Medicine. 11 (77): 4601-4609. doi:10.1016/j.med.2015.04.001. Poser C. M ... The lesions were classified as pattern II in the Lucchinetti system. This case of human EAE also showed Dawson fingers. ...
Lebrun C, Kantarci OH, Siva A, Pelletier D, Okuda DT (February 2018). "Anomalies Characteristic of Central Nervous System ... RISConsortium) (February 2018). "Anomalies Characteristic of Central Nervous System Demyelination: Radiologically Isolated ... "Inflammatory demyelinating diseases of the central nervous system". Handbook of Clinical Neurology. 145: 263-283. doi:10.1016/ ... "Pathological findings in central nervous system demyelination associated with infliximab". Multiple Sclerosis. 26 (9): 1124- ...
Central nervous system disorders, Infectious diseases, All stub articles, Nervous system disease stubs). ... There are five main causes of infections of the central nervous system (CNS): bacterial, viral, fungal, protozoal, and prionic ... Sydenham's chorea Acute disseminated encephalomyelitis Guillain-Barré syndrome Central nervous system viral disease ...
Acute and late radiation damage to the central nervous system (CNS) may lead to changes in motor function and behavior or ... Potential effects on the central nervous system (CNS) are particularly important. A vigorous ground-based cellular and animal ... New approaches in systems biology offer an exciting tool to tackle this challenge. Recently, eight gaps were identified for ... Systems biology approaches to Alzheimer's disease that consider the biochemical pathways that are important in CNS disease ...
Grading of the tumors of the central nervous system See the article Grading of the tumors of the central nervous system. Louis ... The following is a simplified (deprecated) version of the 2021 WHO classification of the tumours of the central nervous system ... 2016). WHO Classification of Tumours of the Central Nervous System (Revised 4th ed.). Lyon: International Agency for Research ... "The 2021 WHO Classification of Tumors of the Central Nervous System: a summary". Neuro-Oncology. 23 (8): 1231-1251. doi:10.1093 ...
... grading system is contained in the volume Histological Typing of Tumours of the Central Nervous System, whose first edition ... Buckner JC, Brown PD, O'Neill BP, Meyer FB, Wetmore CJ, Uhm JH (2007). Central nervous system tumors. Mayo Clin Proc. 2007 Oct; ... The concept of grading of the tumors of the central nervous system, agreeing for such the regulation of the "progressiveness" ... Epub 2007 Jul 6. The 2007 WHO classification of tumours of the central nervous system. Louis DN, Ohgaki H, Wiestler OD, Cavenee ...
Neuroregeneration differs between the peripheral nervous system (PNS) and the central nervous system (CNS) by the functional ... Hatten, Mary (1999). "Central Nervous System Neuronal Migration" (PDF). Annual Review of Neuroscience. Annual Reviews in ... The central nervous system (CNS) is derived from the ectoderm-the outermost tissue layer of the embryo. In the third week of ... the further development of the nervous system other activities may also have effects on the development of the nervous system, ...
The nervous system of vertebrates (including humans) is divided into the central nervous system (CNS) and the peripheral ... Nervous system William E. Skaggs, Scholarpedia The Nervous System at Wikibooks (human) Nervous System at Wikibooks (non-human) ... In vertebrates it consists of two main parts, the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS ... The autonomic nervous system itself consists of two parts: the sympathetic nervous system and the parasympathetic nervous ...
"Central nervous system: Structure, function, and diseases". Medical News Today. 22 December 2017. "Central nervous system: ... The peripheral nervous system connects to the muscles and glands and sends information to the central nervous system. There are ... Central nervous system disease Peripheral neuropathy "Nervous System Diseases - Neurologic Diseases". MedlinePlus. Retrieved ... and viruses can affect the nervous system. For example, meningitis is a common infection of the central nervous system, where ...
The nervous system regulates and controls body functions and activity. It consists of two parts: the central nervous system ( ... Found in the enteric nervous system, within the gastrointestinal tract. In the central nervous system: Grey matter is composed ... In the central nervous system (CNS), the tissue types found are grey matter and white matter. The tissue is categorized by its ... Brodal, Per (March 1, 2010). The Central Nervous System: Structure and Function (Fourth ed.). Oxford University Press. p. 19. ...
As in the sympathetic nervous system, efferent parasympathetic nerve signals are carried from the central nervous system to ... the others being the sympathetic nervous system and the enteric nervous system. The enteric nervous system is sometimes ... Nerve fibres of the parasympathetic nervous system arise from the central nervous system. Specific nerves include several ... The parasympathetic nervous system (PSNS) is one of the three divisions of the autonomic nervous system, ...
Human nervous system consists of the central nervous system (CNS), which comprises the brain and spinal cord, and the ... crucial patterning process that is involved in the development of both the central nervous system and peripheral nervous system ... In the central nervous system, segmentation is involved in the patterning of the neuronal population. Added to that, ... In humans, the spinal cord comprises a major part of the central nervous system (CNS). Along with the brain, it develops from ...
The enteric nervous system can operate autonomously. It normally communicates with the central nervous system (CNS) through the ... The enteric nervous system (ENS) or intrinsic nervous system is one of the main divisions of the autonomic nervous system (ANS ... nervous systems. However, vertebrate studies show that when the vagus nerve is severed, the enteric nervous system continues to ... 3 as many as in the whole nervous system of a cat. The enteric nervous system is embedded in the lining of the gastrointestinal ...
Jellyfish, comb jellies, and related animals have diffuse nerve nets rather than a central nervous system. In most jellyfish ... The evolution of nervous systems dates back to the first development of nervous systems in animals (or metazoans). Neurons ... "Specification of the nervous system". Wormbook. Chapman RF (1998). "Ch. 20: Nervous system". The insects: structure and ... In this species, the nervous system is sexually dimorphic; the nervous systems of the two sexes, males and hermaphrodites, have ...
"Introduction to the Nervous System, Part 2: The Autonomic Nervous System and the Central Nervous System". AMWA Journal: ... The peripheral nervous system is divided into the somatic nervous system, and the autonomic nervous system. The somatic nervous ... The peripheral nervous system can be divided into the somatic nervous system and the autonomic nervous system. In the somatic ... The somatic nervous system includes the sensory nervous system and the somatosensory system and consists of sensory nerves and ...
Willis, William D. (2004). "The Autonomic Nervous System and its central control". In Berne, Robert M. (ed.). Physiology (5. ed ... the sympathetic nervous system, the parasympathetic nervous system, the visceral sensory nervous system and the enteric nervous ... The autonomic nervous system is divided into the sympathetic nervous system and parasympathetic nervous system. The sympathetic ... The enteric nervous system is the intrinsic nervous system of the gastrointestinal system. It has been described as "the Second ...
The vertebrate central nervous system (CNS) is derived from the ectoderm-the outermost germ layer of the embryo. A part of the ... In chordates, dorsal ectoderm forms all neural tissue and the nervous system. Patterning occurs due to specific environmental ... O'Donovan, M.J (1999). "The origin of spontaneous activity in developing networks of the vertebrate nervous system". Current ... Sanes, Dan; Reh, Thomas; Harris, William (2012). Development of the Nervous System (Third ed.). Burlington MA: Elsevier. ISBN ...
The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system ... Mast cells are white blood cells that interact in the neuroimmune system in the brain. Mast cells in the central nervous system ... Mast cells serve the same general functions in the body and central nervous system, such as effecting or regulating allergic ... Van Essen, DC (January 23, 1997). "A tension-based theory of morphogenesis and compact wiring in the central nervous system". ...
... since systemic chemotherapy can have limited penetration into the central nervous system and the central nervous system is a ... Central nervous system (CNS) symptoms such as cranial neuropathies due to meningeal infiltration are identified in less than 10 ... Due to the presence of CNS involvement in 10-40% of adults with ALL at diagnosis, most providers start Central nervous system ( ... Low dose palliative radiation may also help reduce the burden of tumor inside or outside the central nervous system and ...
... while in the rest of the central nervous system inhibition spreads widely. " The theory of the dominant focus has outgrown the ... the dominant is a temporary governing center of excitation in the central nervous system, which creates a hidden readiness of ... In 1911 he defended a thesis on the topic "On the dependence of motor cortical effects on the central collateral effects" in ... He died 31 August 1942, without having read the proofs of a report titled "The system of reflexes in ascending order.", which ...
... as well as parts of the arterial and nervous system. Air pockets around the stapes of Stanocephalosaurus have been hypothesized ... Discovered in the P-G Basin of central India. Originally Parotosuchus rajareddyi, its vertebrate fauna and constriction of its ... Stanocephalosaurus rajareddyi from the Middle Triassic in central India needs further evidence in order to establish its ... with new functional interpretations of the hearing system" (PDF). Zoological Journal of the Linnean Society. 180 (4): 910-929. ...
In late imperial China, the examination system was the primary mechanism by which the central government captured and held the ... After his fourth and final attempt at the shengyuan exam, he had a nervous breakdown, during which he had visions of a heaven ... The "eight virtues" system received many complaints about its lack of academic rigor. In 1121, the local three-colleges system ... The Korean examination system was established in 958 under the reign of Gwangjong of Goryeo. The examination system was spread ...
Many proteins and RNA biomarkers identified are connected to ischemic stroke pathophysiology includes Central Nervous System ...
... the central nervous system and, in men, the testes and semen. Cafferkey went to a 24-hour GP clinic in New Victoria Hospital in ... the virus had remained in her cerebrospinal fluid and feared that it might be in her central nervous system. Personnel in ... it can linger on in parts of the body not protected by the immune system, including fluid in the eye, ...
This suggests a possible systemic component of this disease, despite the predominance of central nervous system features. The ...
I was nervous. I had the worst feeling. Is that him or not him?" She called her employer, who contacted local police, and then ... "Charleston shooting: System failure 'allowed Roof to buy gun' - FBI". BBC. July 10, 2015. Retrieved July 10, 2015. "Charleston ... with Democrats seeing race and gun control as central issues, while Republicans pointing to mental illness and referring to it ... The FBI underwent a 30-day review to examine the lapses in the background-check system that allowed the suspected shooter to ...
... in the central nervous system". Mechanisms of Development. 87 (1): 223-7. doi:10.1016/S0925-4773(99)00155-0. PMID 10495292. ... in 1999 from the original name, Ten-a, and the major site of the protein expression being in the nervous system. Like the Ten-m ... Like the Ten-m family, Ten-m3 plays a critical role in regulating connectivity of the nervous system, particularly in axon ... They are expressed in distinct, but often interconnected, areas of the developing nervous system and in some non-neural tissues ...
... can be explained as cell loss and gliosis or a proliferation of astrocytes in damaged areas of the central nervous system. This ... The region in question includes the SHC2 gene which, in mice and rats, appears to have some function in the nervous system. The ... diagnosis can only be made at autopsy by finding abundant GCIs on histological specimens of the central nervous system. ... Many people affected by MSA experience dysfunction of the autonomic nervous system, which commonly manifests as orthostatic ...
"The Orotomide Olorofim Is Efficacious in an Experimental Model of Central Nervous System Coccidioidomycosis". Antimicrobial ...
Papillary tumors of the central nervous system and particularly of the pineal region are very rare and so diagnosing them is ... WHO classification of tumours of the central nervous system, chapter 7, Eds: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, IARC ... Papillary tumors of pineal region are extremely rare, constituting 0.4-1% of all central nervous system tumors. These tumors ... in 2003 and were introduced in the World Health Organization (WHO) classification of Central Nervous System (CNS) in 2007. ...
Fyfe, was "a nervous wreck". Andrew Banks Fyfe was issued with a notice to quit in February 1933. His response was that he had ... The hotel is constructed with a flexible non load bearing partition system. It is finished with cement render. Despite a number ... The first and second storeys have central recessed balconies dominated above by a pediment in the parapeted roofline. ...
... but with reduced central nervous system distribution and hence is expected to have a reduced risk of seizures and other central ... However, it has a small (1%) risk of seizures and has central nervous system side effects like anxiety and insomnia due to off- ... Similar to enzalutamide and apalutamide, but with increased efficacy as an AR antagonist, little or no central nervous system ... and little or no central nervous system distribution. However, has a much shorter terminal half-life and lower potency. ...
Some Phalaris species contain gramine, which can cause brain damage, other organ damage, central nervous system damage and ...
Axons in the central nervous system do not regenerate after injury the same way that axons in the peripheral nervous system do ... Lopez PH (2014). "Role of myelin-associated glycoprotein (siglec-4a) in the nervous system". Advances in Neurobiology. 9: 245- ... Lopez PH (2014). "Role of myelin-associated glycoprotein (siglec-4a) in the nervous system". Advances in Neurobiology. 9: 245- ...
Tarkhnishvili's most significant contribution was the discovery of the influence of X-rays on the central nervous system, ... Here he gave five public lectures, which he went on to publish in Russian as "The Role of the Nervous System in Animal Movement ... X-ray exposure depended on neither analgesia nor sensitive skin but on the moderating effect of the central nervous system (CNS ... Tarkhanov engaged in experimental studies on the phenomena of summation in the nervous system (1869). He also studied the ...
The neuraxis or sometimes neuroaxis is the axis of the central nervous system. It denotes the direction in which the central ... The embryonic nervous system in mammals can be said to have a standard arrangement. Humans (and other primates, to some degree ... First, the neural tube establishes the anterior-posterior dimension of the nervous system, which is called the neuraxis. ... nervous system lies. During embryological development, the neuraxis is bent by various flexures, contributing to the mature ...
... entral nervous system stimulation or depression, resulting in hallucinations or disturbances in motor function or thinking or ... Neutral group: This was a diverse group including most of the African countries, Central America, sub-Andean South America, ... The International Narcotics Board states: The fact that the system generally works well is mainly due to the estimates system ... system that would complement the existing system without altering the balance of its relatively closed supply and demand system ...
... severe manifestations of this disease may involve the respiratory system, central nervous system, gastrointestinal system, or ... It has been diagnosed throughout the contiguous United States, Western Canada, and parts of Central and South America. Rocky ... the elaborate biocontainment systems of today had not been invented. Research into this disease in Montana is a sub-plot of the ... especially if they have experienced damage to multiple organ systems. Preventive therapy in healthy people who have had recent ...
2017). A study on the anatomy of the vertebra of Vegasaurus molyi and its implications for the anatomy of the nervous system of ... 1929 More Kronosaurus fossils were discovered in central Queensland near the site of the type specimen's discovery. 1930 ... nov., a new highly derived elasmosaurid from the upper Maastrichtian of central Chile". Journal of Vertebrate Paleontology. 34 ... of central North America". Univ. Kansas Paleont. Cont. New Series. 11: 15. Stukeley, W. (1719). "An account of the impression ...
The researchers were interested in studying how the nervous system recovered during arm regeneration as this could have ... Amphiura filiformis has a central disc up to 10 mm (0.4 in) in diameter and five slender arms up to 100 mm (4 in) long. The ...
Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ...
Szymański M, Barciszewski J (2009). "Noncoding RNAs in the Development, Function and Pathologies of the Central Nervous System ... Qureshi IA, Mattick JS, Mehler MF (June 2010). "Long non-coding RNAs in nervous system function and disease". Brain Research. ...
... projections from a single neuron or a defined population of neurons to their various targets throughout the nervous system. ... Rinaman L, Schwartz G (March 2004). "Anterograde transneuronal viral tracing of central viscerosensory pathways in rats". The ... "Anterograde transport of HSV-1 and HSV-2 in the visual system". Brain Research Bulletin. 28 (3): 393-9. doi:10.1016/0361-9230( ... is taken into intracellular organelles and is transported by the endogenous neuronal transport system including kinesin-1, ...
"Understanding Central Nervous System Effects of Deliriant Hallucinogenic Drugs through Experimental Animal Models". ACS ...
Lothian played a central role in enlisting American support for economic aid to the British war effort. His change of view of ... In October 1911, Kerr suffered a nervous breakdown. During a visit to India in 1912, Kerr intensely studied the religions of ... Kerr stated the projected League of Nations should work towards world-wide disarmament and for a system of "public law" against ... "a square deal in Central Europe". In January 1935, he went to Germany as the general secretary of the Rhodes Society, where he ...
USAF weapon systems officer Captain Jeffrey Feinstein became the fifth and last U.S. ace of the war when he and his pilot shot ... In the Central Highlands 50 PAVN and five ARVN were reported killed, while 36 B-52s dropped 1,000 tons of bombs on PAVN staging ... Thiệu was described as being nervous in the face of pressure from the U.S. and recent PAVN/VC attacks on the approaches to ... The JGS reported that 82 PAVN/VC had been killed for the loss of two ARVN in ten clashes, many in ambushes in the Central ...
v t e (Central nervous system disorders, Myelin disorders, All stub articles, Nervous system disease stubs). ... Meningococcal myelitis is a disorder of the myelin sheath, which is a primary actor in the central nervous system. It has been ...
He later claimed that the Communist Party had paid Purcell "to do in a Central Organization". On December 16, 1952, Hubbard was ... "cause and cure of nervous tension", which he was going to call either The Dark Sword or Excalibur or Science of the Mind, and ... "something on the accounting system of dumping it all in a barrel outside the door and hauling the barrel down to a bank every ...
TTC39B is well expressed in muscles, internal organs, secretory organs, reproductive organs, the immune system, and the nervous ... Isoform 2 uses an alternate in-frame splice site in the central coding region, compared to variant 1, which results in a ... Isoform 3 and 4 have multiple differences in the central coding region but maintain the reading frame compared to isoform 1. ... system. TTC39B is expressed in a multitude of tissues: testis, lung, islets of langerhans, pancreas, kidney, pooled germ cell ...
Your brain and spinal cord serve as the main processing center for your entire nervous system. They control all the workings ... The central nervous system is composed of the brain and spinal cord. ... The central nervous system is composed of the brain and spinal cord. Your brain and spinal cord serve as the main "processing ... Organization of the nervous system. In: Boron WF, Boulpaep EL, eds. Medical Physiology. 3rd ed. Philadelphia, PA: Elsevier; ...
Clinical resource with information about Spongy degeneration of central nervous system and its clinical features, ASPA, ... Spongy degeneration of central nervous system. Synonyms. ACY2 deficiency; ASP deficiency; Aminoacylase 2 deficiency; ... Spongy degeneration of the central nervous system; Von Bogaert-Bertrand disease. Modes of inheritance. Autosomal recessive ... Abnormality of the nervous system*Abnormal pyramidal sign. Abnormal pyramidal sign. *MedGen UID: 68582 ...
Central Nervous System (CNS) depressants are medicines that include sedatives, tranquilizers, and hypnotics. These drugs can ... Hypoxia can have short- and long-term mental effects and effects on the nervous system, including coma and permanent brain ...
Arboviral Infections of the Central Nervous System -- United States, 1985 In 1985, arboviral infections of the central nervous ... No human cases were reported in the eastern and central United States for the second consecutive year, and avian surveillance ... system (CNS) were reported among 90 persons in the United States (Table 1, Figures 1 and 2). A St. Louis encephalitis (SLE) ...
... of this initiative is to study mechanisms of HIV-1 persistence and eradication strategies specifically focused on the central ... nervous system in the context of viral suppression. ... Eradication of HIV-1 from Central Nervous System Reservoirs. ... Home , Funding , Grant Writing & Approval Process , Concept Clearances , Eradication of HIV-1 from Central Nervous System ... The long-lived cells in the central nervous system (CNS), including astrocytes, perivascular macrophages and microglia, have ...
Problems in this system might play a role in neurological disorders. ... Immune System. References: Structural and functional features of central nervous system lymphatic vessels. Louveau A, Smirnov I ... The brain, part of the central nervous system, has blood vessels but has been thought to lack lymphatic vessels, as they ve ... The discovery of a pathway for immune cells to exit the central nervous system raises the question of whether disruption of ...
SEARCH RESULTS for: Central Nervous System Stimulation [Drug Class] (1006 results) *Share : JavaScript needed for Sharing tools ...
This RFA, Central Nervous System As The HIV Sanctuary, is related to the priority area of neurological complications of HIV ... CENTRAL NERVOUS SYSTEM AS THE HIV SANCTUARY Release Date: September 4, 1998 RFA: NS-99-002 P.T. National Institute of ... "CENTRAL NERVOUS SYSTEM AS THE HIV SANCTUARY" must be entered. The RFA label available in the application form PHS 398 must be ... invite investigator-initiated research grant applications that address the potential role of the central nervous system (CNS) ...
Zinc and the Central Nervous System. Zinc and Health: Workshop Summary. Session V. Session V, Zinc and the Central Nervous ... Zinc and the Central Nervous System. Notice: Historical Content. This is an archival or historical document and may not reflect ... System focused on the anatomy, physiology, functional implications, and the pathology of zinc in the CNS. The fact that zinc is ...
The authors review the most common congenital anomalies of the central nervous system (CNS): neural tube defects (NTDs), ... Central nervous system anomalies L Csabay 1 , I Szabó, C Papp, E Tóth-Pál, Z Papp ... Central nervous system anomalies L Csabay et al. Ann N Y Acad Sci. 1998. . ... Prenatal diagnosis of central nervous system malformations]. Langmár Z, Németh M, Csaba Á, Szigeti Z, Joó JG. Langmár Z, et al. ...
... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. ... Types histologiques des tumeurs du système nerveux central / K. J. Zülch, avec la collaboration de pathologistes de 14 pays ... Tipos histológicos de tumores del sistema nervioso central / K. J. Zülch, en colaboración con anatomopatologos de catorce ...
... the primary immune cells of the central nervous system-including the retina of the eye-serve as ... A research team at Massachusetts Eye and Ear has shown that microglia, the primary immune cells of the central nervous system- ... Microglia, the Immune Cells of the Central Nervous System, Shown to Regulate Neuroinflammation ... Microglia, the Immune Cells of the Central Nervous System, Shown to Regulate Neuroinflammation ...
Persistent HIV in Central Nervous System Linked to Cognitive Impairment. July 15, 2019 ... The new findings suggest that the presence of persistent HIV-infected cells in the central nervous system (CNS), despite long- ... These findings suggest that HIV can persist in the nervous system even when the virus is suppressed in a patients blood with ... In Rare Cases, Immune System Fails Despite HIV Suppression. Long-Acting Injectable Form of HIV Prevention Outperforms Daily ...
... You may be trying to access this ... Thus the central nervous system is repair competent but lacks endogenous stem cell resources. To make transplants clinically ... The adult central nervous system (CNS) has limited de novo neurogenesis (Blight, 2002; Bechmann, 2005) and only minimal ... Bechmann I. Failed central nervous system regeneration - A downside of immune privilege? Neuromol Med. 2005;7:217-228. ...
... binds with high affinity to a specific benzodiazepine receptor that occurs exclusively in the central nervous system. The ... Benzodiazepine receptor: demonstration in the central nervous system H Möhler et al. Science. 1977. . ... Benzodiazepine receptor: demonstration in the central nervous system H Möhler, T Okada ... Micromolar affinity benzodiazepine receptors: identification and characterization in central nervous system. Bowling AC, ...
Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH2/UH3) RFA-NS-15-006. ... BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH2/UH3) ... Efforts to develop neurotechnology for fundamental study of the central nervous system ... the nervous system disorders being studied and have expertise in the implementation of translational research. ...
childhood central nervous system germ cell tumor. General Information About Childhood Central Nervous System (CNS) Germ Cell ... but a modified Chang staging system has traditionally been used. Staging evaluation of central nervous system (CNS) GCTs ... Childhood Central Nervous System Germ Cell Tumors Treatment (PDQ®) (Health professionals) National Cancer Institute. Post Date ... Central nervous system (CNS) germ cell tumors (GCTs), similar to gonadal and extragonadal GCTs, have demonstrated sensitivity ...
Using Spatial Genomics to Study the Central Nervous System in Health and Disease ... Using Spatial Genomics to Study the Central Nervous System in Health and Disease. Download VideoCast. You can download this ... Using Spatial Genomics to Study the Central Nervous System in Health and Disease. ... Using Spatial Genomics to Study the Central Nervous System in Health and Disease ...
NIA-funded study estimates the number of adults with dementia taking multiple medicines that affect the central nervous system. ... Prevalence of central nervous system-active polypharmacy among older adults with dementia in the US. JAMA. 2021;325(10):952-961 ... Nearly 14% of older adults with dementia are prescribed a combination of medicines affecting the central nervous system May 27 ... About 14% of older adults with dementia filled prescriptions for multiple medications that target the central nervous system ( ...
The central nervous system (CNS). The central nervous system consists of the brain and spinal cord. Both are wrapped in a thin ... The central nervous system of a growing fetus starts with a simple structure called the neural groove that folds in to form ... Birth defects of the central nervous system are called neural tube defects (NTDs). NTDs include conditions called spina bifida ...
Localization of the Slack potassium channel in the rat central nervous system Arin Bhattacharjee et al. J Comp Neurol. 2002. . ... Localization of the Slack potassium channel in the rat central nervous system Arin Bhattacharjee 1 , Li Gan, Leonard K ... Localization of the Na+-activated K+ channel Slick in the rat central nervous system. Bhattacharjee A, von Hehn CA, Mei X, ... Within the auditory system, the medial nucleus of the trapezoid had a robust signal consistent with staining of the giant ...
Researchers have identified a drug that helps neurons in the central nervous system heal. Neurons are surrounded by support ... branch heading into the central nervous system via the spinal cord and the other becoming part of the peripheral nervous system ... Injured motor and sensory neurons in the central nervous system - the brain and spinal cord - have limited ability to heal, so ... Louis have discovered that an FDA-approved drug acts on support cells in the central nervous system to encourage sensory ...
NOREPINEPHRINE AND EPINEPHRINE IN THE CENTRAL NERVOUS SYSTEM Message Subject (Your Name) has forwarded a page to you from ...
... and in the central nervous system, such as spinal cord injury. ... after traumatic injury in the peripheral nervous system, such ... botulinum neurotoxin; peripheral nervous system; central nervous system; peripheral nerve injury; spinal cord injury; nerve ... 2. Peripheral Nervous System. The PNS refers to the part of the nervous system outside the brain and spinal cord. The primary ... 3. Central Nervous System. As already mentioned in Section 1, this review does not consider all the possible lesions of the CNS ...
Primary central nervous system lymphoma (PCNSL) is a rare tumor that accounts for ,1%-4% of primary CNS tumor. PCNSLs are class ... Primary Central Nervous System Lymphoma Involving Entire Ventricular System. Authors. Primary Central Nervous System Lymphoma ... Author report a rare case of PCNSL presenting as an intracranial mass involving the entire ventricular system, in an ...
There have been many reviews of the central nervous system (CNS) complications in MM but there are none on intracranial and ... Myeloma of the central nervous system: strong association with unfavorable chromosomal abnormalities and other high-risk ... Multiple myeloma involving central nervous system: high frequency of chromosome 17p13.1 (p53) deletions. British journal of ... Myeloma of the central nervous system: association with high-risk chromosomal abnormalities, plasmablastic morphology and ...
  • It's broken down into the somatic nervous system and the autonomic nervous system. (antiessays.com)
  • The somatic nervous system consists of nerves that provide voluntary control over skeletal muscle contraction. (antiessays.com)
  • The somatic nervous system is responsible for coordinating the body's movements, and also for receiving external stimuli. (wikidoc.org)
  • The autonomic nervous system consists of sympathetic and parasympathetic nerves that provide involuntary control over smooth muscle, cardiac muscle, and gland activity and secretions. (antiessays.com)
  • The hypothalamus, located below the thalamus, is responsible for certain metabolic processes and other autonomic nervous system activities like body temperature, sleep, and appetite. (antiessays.com)
  • According to "American Accreditation Health Commission," The hypothalamus is responsible for certain metabolic processes and other activities of the autonomic nervous system. (antiessays.com)
  • The autonomic nervous system is then split into the sympathetic division , parasympathetic division , and enteric division . (wikidoc.org)
  • The Central Nervous System (CNS) and the Autonomic Nervous System (ANS), also called vegetative nervous system. (flowsandforms.com)
  • The autonomic nervous system controls the vegetative system, which is autonomous: circulatory system, digestive system, respiratory system, reproductive and urinary systems and endocrine system. (flowsandforms.com)
  • There are equally muscles that are connected to the autonomic nervous system and that are involuntary control muscles and line the walls of both blood vessels and internal organs. (flowsandforms.com)
  • To understand why regeneration occurs in the peripheral but not the central nervous system, Cavalli studies a unique cell type that spans both systems: sensory neurons of the dorsal root ganglia. (sci-info-pages.com)
  • A long, thin arm called an axon branches out from each cell body in opposite directions, with one branch heading into the central nervous system via the spinal cord and the other becoming part of the peripheral nervous system as it descends into the body. (sci-info-pages.com)
  • Despite being two parts of the same cell, the peripheral and central axonal branches do not respond identically after injury. (sci-info-pages.com)
  • The peripheral parts regrow and recover much faster and more completely than the central ones. (sci-info-pages.com)
  • Cavalli and first author Oshri Avraham, PhD, a staff scientist, suspected that the differences in regeneration between the two branches may come down to differences between the behavior of support cells in response to injury to the central versus peripheral axon branches. (sci-info-pages.com)
  • To investigate that possibility, the researchers compared gene expression in five kinds of support cells in the ganglion, after injury to the peripheral and central branches of the sensory neuron. (sci-info-pages.com)
  • Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds. (cam.ac.uk)
  • It was concluded that the myelin-forming cells responsible for the formation of the "peripheral type" myelin within the cyst were probably Schwann cells derived from peripheral nervous elements accompanying some subarachnoid blood vessels. (elsevier.com)
  • It could not be determined whether the axons within the "peripheral type" sheaths were part of the central or peripheral nervous systems. (elsevier.com)
  • Thus, with a didactical purpose, these organs, according to their ubication, can be divided in two parts: the central nervous system (CNS) and the peripheral nervous system (PNS). (wikidoc.org)
  • The two systems are central nervous system (CNS)and the peripheral nervous system (PNS). (wikidoc.org)
  • They are the core components of both the central nervous system & peripheral nervous system . (wikidoc.org)
  • The peripheral nervous system is formed by all the nerves that do not belong to the central nervous system. (flowsandforms.com)
  • The nerves that form the peripheral nervous system are the cranial nerves, which connect the head and face directly to the brain, the nerves that connect the eyes and the nose to the brain, and all the nerves that connect the spinal marrow to the rest of the body. (flowsandforms.com)
  • The authors review the most common congenital anomalies of the central nervous system (CNS): neural tube defects (NTDs), ventriculomegaly/holoprosencephaly, hydranencephaly, holoprosencephaly sequence, iniencephaly, and microcephaly. (nih.gov)
  • Birth defects of the central nervous system are called neural tube defects (NTDs). (vic.gov.au)
  • The spinal cord, as a key part of our body's central nervous system, contains millions of neurons that actively convey sensory and motor (movement) information to and from the brain. (nih.gov)
  • Drainage of venous angioma is fully integrated with the body's venous system, therefore, in most cases there is no clinical signs and rare bleeding. (lookformedical.com)
  • Its main function is to connect the central nervous system to the limbs and organs. (antiessays.com)
  • At gross anatomy, the nervous system can be grouped in distinct organs, these being actually stations which the neural pathways cross through. (wikidoc.org)
  • Nerves are like pieces of string connecting nervous centres to organs. (flowsandforms.com)
  • The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges. (lookformedical.com)
  • Maps of the lymphatic system: old (left) and updated to reflect the new discovery. (nih.gov)
  • The lymphatic system carries white blood cells and other immune cells through a network of vessels and tissues, including lymph nodes. (nih.gov)
  • The lymphatic system also serves as a connection between tissues and the bloodstream, performing several functions such as removing dead blood cells and other waste. (nih.gov)
  • The brain, part of the central nervous system, has blood vessels but has been thought to lack lymphatic vessels, as they ve never been found. (nih.gov)
  • To better understand the connections between the lymphatic system and the brain, a team led by Drs. Antoine Louveau and Jonathan Kipnis of the University of Virginia School of Medicine used high-powered microscopes to examine the brains of mice. (nih.gov)
  • These vessels contained markers of the lymphatic system. (nih.gov)
  • Structural and functional features of central nervous system lymphatic vessels. (nih.gov)
  • Traditionally, the Central Nervous System (CNS) has been viewed as an immune-privileged environment with no lymphatic vessels. (nih.gov)
  • Researchers at Washington University School of Medicine in St. Louis have discovered that an FDA-approved drug acts on support cells in the central nervous system to encourage sensory neurons to regrow after injury. (sci-info-pages.com)
  • Injured motor and sensory neurons in the central nervous system - the brain and spinal cord - have limited ability to heal, so people who survive such injuries can be left with chronic paralysis, numbness and pain. (sci-info-pages.com)
  • Researchers at Washington University School of Medicine in St. Louis have identified a drug that helps sensory neurons in the central nervous system heal. (sci-info-pages.com)
  • A 70% loss of motor neurons was present five months after an intraperitoneal injection of assembled A53T α-synuclein or cerebellar extract with type II α-synuclein filaments from an individual with a neuropathologically confirmed diagnosis of multiple system atrophy. (cam.ac.uk)
  • Scientists have long sorted these spinal neurons into what they call "cardinal" classes, a classification system based primarily on the developmental origin of each nerve cell. (nih.gov)
  • Two Main Cells Nervous System Health And Social Care The two main types of cells in the nervous system are neurons and neuroglia. (antiessays.com)
  • The nervous system is a highly specialized network whose principal components are nerves called neurons . (wikidoc.org)
  • Neurons are interconnected to each other in complex arrangements, and have the property of conducting, using electrochemical signals, a great variety of stimuli both within the nervous tissue as well as from and towards most of the other tissues. (wikidoc.org)
  • The nervous system is, on a small scale, primarily made up of neurons . (wikidoc.org)
  • Neurons are sensors that send electric messages to the Central Nervous System which send the electric messages back to the neurons telling them how to react, where the messages are finally sent back directly to the brain. (wikidoc.org)
  • Relay system by relay neurons (also called interneurons ), which transmit impulses between the sensory and motor neurones. (wikidoc.org)
  • There are nerves that are linked to the autonomic system, vegetative parasympathetic nerves and sympathetic nerves. (flowsandforms.com)
  • Il existe de nombreuses études consacrées aux complications du MM au niveau du système nerveux central, mais il n'en existe aucune sur l'infiltration intracrânienne et leptoméningée. (who.int)
  • They are the actual nerve cells that transmit impulses of the nervous system. (antiessays.com)
  • The discovery of a pathway for immune cells to exit the central nervous system raises the question of whether disruption of this route may be involved in neurological disorders that are associated with immune system dysfunction, such as multiple sclerosis, meningitis, and Alzheimer's disease. (nih.gov)
  • A research team at Massachusetts Eye and Ear has shown that microglia, the primary immune cells of the central nervous system-including the retina of the eye-serve as "gatekeepers," or biosensors and facilitators, of neuroinflammation in a preclinical model of autoimmune uveitis. (nih.gov)
  • Micromolar affinity benzodiazepine receptors: identification and characterization in central nervous system. (nih.gov)
  • The long-lived cells in the central nervous system (CNS), including astrocytes, perivascular macrophages and microglia, have been shown to support both HIV infection and variable levels of replication. (nih.gov)
  • The parasympathetic nervous system, on the other hand, is evident when a person is resting and feels relaxed, and is responsible for such things as the constriction of the pupil, the slowing of the heart, the dilation of the blood vessels, and the stimulation of the digestive and genitourinary systems. (wikidoc.org)
  • The central nervous system is composed of the brain and spinal cord. (medlineplus.gov)
  • Your brain and spinal cord serve as the main "processing center" for your entire nervous system. (medlineplus.gov)
  • Hypoxia can have short- and long-term mental effects and effects on the nervous system, including coma and permanent brain damage. (nih.gov)
  • The researchers surmise that these vessels may serve as a second step in the drainage of fluid from the brain, after it's drained into the cerebrospinal fluid through the glymphatic system. (nih.gov)
  • The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to pursue translational and clinical studies for recording and/or stimulating devices to treat nervous system disorders and better understand the human brain. (nih.gov)
  • About 14% of older adults with dementia filled prescriptions for multiple medications that target the central nervous system (CNS), or the brain and spinal cord, according to a recent study. (nih.gov)
  • When compared to other animals' brains, the human brain is a more complex central nervous system. (antiessays.com)
  • The central nervous system (CNS) represents the largest part of the nervous system, including the brain and the spinal cord . (wikidoc.org)
  • The central nervous system is formed by the encephalon (brain) and the spinal marrow. (flowsandforms.com)
  • however, hypotension is common and may result from a number of factors, including vasodilation of the cutaneous vessels, pooling of the blood in the venous system, and dehydration. (medscape.com)
  • Central nervous system venous angioma. (lookformedical.com)
  • Veins in a venous angioma are surrounded by normal nervous tissue, unlike a CENTRAL NERVOUS SYSTEM CAVERNOUS HEMANGIOMA that lacks intervening nervous tissue. (lookformedical.com)
  • The regeneration pattern of two identified central neurones was studied in the leech Hirudo medicinalis . (biologists.com)
  • Further work will explore whether problems in this system might play a role in neurological disorders such as Alzheimer's disease, meningitis, and multiple sclerosis. (nih.gov)
  • Thus the central nervous system is repair competent but lacks endogenous stem cell resources. (lww.com)
  • Diazepam, a potent minor tranquilizer, binds with high affinity to a specific benzodiazepine receptor that occurs exclusively in the central nervous system. (nih.gov)
  • Lack of αMSH is likely the principal cause of obesity ( 3 , 5 ) due to the loss of agonist signaling at central melanocortin receptors (MC-R), melanocortin-3 receptor (MC3-R), and melanocortin-4 receptor (MC4-R), each of which plays a distinct role in the regulation of energy homeostasis ( 6 , 7 , 8 ). (diabetesjournals.org)
  • Organization of the vessels in the human central nervous system will now need to be determined. (nih.gov)
  • To find out, they fed mice fenofibrate - a drug that activates PPAR alpha - for two weeks before injuring the mice's sensory axon branch heading into the central nervous system. (sci-info-pages.com)
  • Three days after the injury, the central branches of the sensory neuron axons had regrown about twice as much in the mice that had received fenofibrate than in those that had received a placebo. (sci-info-pages.com)
  • POMC peptides in the central nervous system (CNS) are essential in the regulation of energy intake and expenditure as demonstrated in studies using compound mutant mice ( Pomc −/− Tg/ +) expressing a Pomc transgene that selectively restored pituitary POMC in Pomc −/− mice to produce a neural-selective POMC deficiency ( 4 ). (diabetesjournals.org)
  • It is the system that regulates activities that are under conscious control. (wikidoc.org)
  • The cardiovascular system circulates blood, nutrients, and gases throughout the body. (nih.gov)
  • Of all the systems in the body, the nervous system is the slowest to react, because it is the deepest. (flowsandforms.com)
  • In addition, infants have an immature thermoregulatory system, and elderly persons have impaired perception of changes in body and ambient temperatures and a decreased capacity to sweat. (medscape.com)
  • This tumor-like mass with the large vascular space is filled with blood and usually appears as a strawberry-like lesion in the subcutaneous areas of the face, extremities, or other regions of the body including the central nervous system. (lookformedical.com)
  • RESEARCH OBJECTIVES Background HIV can penetrate the nervous system resulting in a wide range and severity of pathological and clinical manifestations. (nih.gov)
  • Halvtid Stavroula Anastasopoulou: Posterior reversible encephalopathy syndrome and other severe central nervous system adverse events (SAEs) in the NOPHO ALL2008 protocol- Clinical and radiological findings, genetic risk factors and prognosis. (ki.se)
  • Halvtidsseminarier Halvtid Stavroula Anastasopoulou: Posterior reversible encephalopathy syndrome and other severe central nervous system adverse events (SAEs) in the NOPHO ALL2008 protocol- Clinical and radiological findings, genetic risk factors and prognosis. (ki.se)
  • There are muscles that are linked to the central nervous system, which are the voluntary control muscles. (flowsandforms.com)
  • When this happens, the heart beats faster or the blood pressure increases, the trachea expands, breathing becomes heavier, the pupil dilates, there is perspiration, the blood flows to the voluntary muscles of the skeleton (connected to the central nervous system) and the sexual and digestive systems become inactive. (flowsandforms.com)
  • Central Nervous System (CNS) depressants are medicines that include sedatives, tranquilizers, and hypnotics. (nih.gov)
  • Author report a rare case of PCNSL presenting as an intracranial mass involving the entire ventricular system, in an immunocompetent 36-year-old male with severe headache, decreased vision, and unsteady gait. (iasp-pain.org)
  • The PNS consists of all the other nervous structures that do not lie within it. (wikidoc.org)
  • The PNS is made up of nerves that are cordlike bundles of nerve fiber that transmit the impulses and ganglia that are knot-like masses of nerve cells all situated outside the central nervous system. (antiessays.com)
  • Most of them displayed typical mature or developing "central type" myelin sheaths. (elsevier.com)
  • Glial cells are non- neuronal cells that provide support and nutrition, maintain homeostasis , form myelin , and participate in signal transmission in the nervous system . (wikidoc.org)
  • Inclusion criteria for this report were a positive cerebrospinal fl uid (CSF) culture for Mycobacterium tuber- of Central culosis complex or a positive CSF TB PCR result. (cdc.gov)
  • The new findings suggest that the presence of persistent HIV-infected cells in the central nervous system (CNS), despite long-term ART, may play a role in neurocognitive impairment. (nih.gov)
  • Primary Central Nervous System Lymphoma Involving Entire Ventricular System. (iasp-pain.org)
  • As aggressive neurosurgery and adjuvant therapy have become standard care for most patients with primary central nervous system (CNS) tumors, limitations of posttreatment neuroimaging techniques have become more apparent. (elsevier.com)
  • The pathway was not turned up after injury to central axonal branches, and was actually dialed down after spinal cord injury in the central nervous system. (sci-info-pages.com)
  • In 1985, arboviral infections of the central nervous system (CNS) were reported among 90 persons in the United States (Table 1, Figures 1 and 2). (cdc.gov)
  • There have been many reviews of central nervous system complications in MM but there are none on intracranial and leptomeningeal infiltration of MM. We review this here along with our clinicopathological experience and a summary of our present knowledge of this condition. (who.int)
  • There have been many reviews of the central nervous system (CNS) complications in MM but there are none on intracranial and leptomeningeal infiltration of MM. This review focuses on the infiltrative complications and intracranial plasmacytomas with no further discussion of the other possible CNS complications. (who.int)
  • The same was the case when cerebellar extracts from a case of multiple system atrophy with type II α-synuclein filaments were administered intraperitoneally, intravenously or intramuscularly. (cam.ac.uk)
  • The so-called sympathetic trunk, next to the spine, is formed by a group of nervous cells that do not form part of the CNS and which are called ganglia. (flowsandforms.com)
  • If Circuit of The Americas were a living organism, race control would be its central nervous system. (circuitoftheamericas.com)
  • The human nervous system can be observed both with gross anatomy , (which describes the parts that are large enough to be seen with the plain eye,) and microanatomy , (which describes the system at a cellular level. (wikidoc.org)
  • The goal of this initiative is to study mechanisms of HIV-1 persistence and eradication strategies specifically focused on the central nervous system in the context of viral suppression. (nih.gov)
  • The role of the enteric nervous system is to manage every aspect of digestion, from the esophagus to the stomach, small intestine and colon. (wikidoc.org)
  • Central nervous system tuberculosis (TB) was identi- for the study population are detailed in the online Appen- fi ed in 20 cases of unexplained encephalitis referred to the California Encephalitis Project. (cdc.gov)
  • University of Virginia Health System. (nih.gov)
  • These findings suggest that HIV can persist in the nervous system even when the virus is suppressed in a patient's blood with medication. (nih.gov)
  • The sympathetic nervous system responds to impending danger or stress, and is responsible for the increase of one's heartbeat and blood pressure, among other physiological changes, along with the sense of excitement one feels due to the increase of adrenaline in the system. (wikidoc.org)
  • Nervous systems are found in many multicellular animals but differ greatly in complexity between species. (wikidoc.org)