A non-steroidal anti-fertility agent with anti-hormonal properties.
Delay in the attachment and implantation of BLASTOCYST to the uterine ENDOMETRIUM. The blastocyst remains unattached beyond the normal duration thus delaying embryonic development.
A fold of the mucous membrane of the CONJUNCTIVA in many animals. At rest, it is hidden in the medial canthus. It can extend to cover part or all of the cornea to help clean the CORNEA.
Spasmodic contraction of the smooth muscle of the bronchi.

Antimutagenic effects of centchroman--a contraceptive and a candidate drug for breast cancer in multiple mutational assays. (1/5)

Centchroman (CC), a non-steroidal oral contraceptive and a candidate drug for breast cancer, has been reported to exhibit partial to complete remission of lesions in 40.5% of breast cancer patients. The potent anti-oestrogenic activity, negligible side-effects and anti-breast cancer activity of CC prompted us to evaluate the antimutagenic effects of this compound in a bacterial mutagenicity assay and CHO/HPRT and AS52/GPT mutation assays in vitro and in vivo in female Swiss albino mice as measured by both sister chromatid exchange (SCE) and chromosome aberrations (CA) against three known positive mutagen compounds, dimethylbenz[a]anthracene (DMBA), cyclophosphamide (CP) and mitomycin C (MMC). Antimutagenicity assays in Salmonella strains TA97a, TA100, TA98 and TA102 were carried out against commonly used known positive mutagens, sodium azide, 4-nitro-o-phenylenediamine, cumine hydroperoxide, 2-aminofluorene and danthron. A significantly reduced number of bacterial histidine revertant colonies was observed in the plates treated with 0.1, 1, 5 and 10 microg/plate CC and a positive compound when compared with bacterial plates treated with the respective positive compound alone. Ethyl methanesulfonate (EMS), a commonly used positive mutagen for CHO/HPRT and AS52/GPT gene mutation assays, was used for antimutagenicity assay in these cells. CC exhibited protective effects against the mutagenicity of EMS in these two mammalian cell mutation assays, CHO/HPRT and AS52/GPT. In the in vivo studies, pretreatment with CC reduced DMBA-induced SCE and CA and CP- and MMC-induced CA when compared with the group treated only with the positive compounds. These results indicate that CC can reduce the mutagenic effects of known genotoxic compounds.  (+info)

Polyphenols sensitization potentiates susceptibility of MCF-7 and MDA MB-231 cells to Centchroman. (2/5)

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Effect of centchroman on tubal transport and preimplantation embryonic development in rats. (3/5)

A single oral administration of centchroman (1.25 mg/kg) to adult female rats within 24 h of mating induced slight acceleration in the rate of transport of embryos through the oviducts. The compound did not seem to produce any deleterious effect on preimplantation embryonic development since well organized and apparently normal embryos were collected from the genital tract up to Day 12 of pregnancy. The recovery rate of embryos from centchroman-treated rats was, however, significantly reduced after Day 4 of pregnancy. There was some stimulation in the rate of cleavage of embryos and morula to blastocyst transformation, but retardation in the shedding of the zona pellucida. The rate of blastocyst formation was not altered when 6-8-cell embryos collected from the oviducts of control rats were transferred to the uteri of control or centchroman-treated females. A delay in zona shedding was observed in the centchroman-treated recipients.  (+info)

Viability and development of 'tube-locked' mouse embryos. (4/5)

'Tube-locked' morulae and blastocysts were recovered from the ampulla of the oviduct of centchroman-treated mice between Days 4 and 12 post coitum and transferred to the uteri of pseudopregnant female mice. Pregnancy and implantation rates were lower and the post-implantation resorption rate was higher in the treated than in the control group. There was little difference in the pregnancy or implantation rates between embryos recovered on Days 4 or 12 post coitum, but the resorption rate increased with increasing duration of embryos in the oviducts and was 100% for the Day-12 embryos. The resorption rate was similar even when these embryos were transferred to the sterile uterine horn of unilaterally pregnant mice. Centchroman did not produce any deleterious effect on embryos which survived until Day 19 of pregnancy in foster mothers. The average fetal weight was also comparable to those of control fetuses.  (+info)

Duration of anti-implantation action of the triphenylethylene anti-oestrogen centchroman in adult female rats. (5/5)

The duration of the anti-implantation action of a single oral post-coital dose (1.25 mg kg-1) of a triphenylethylene anti-oestrogen, centchroman, was determined in adult rats. The effects of centchroman were compared with those of tamoxifen. In rats undergoing delay, centchroman administered orally on day 7 post-coitum prevented the induction of implantation of delayed blastocysts by an implantation inducing dose (1 micrograms per rat, s.c.) of oestrone which was administered earlier than 120 h after centchroman treatment. In tamoxifen (0.2 mg kg-1, orally) pretreated rats, oestrone administered at 144 h or later induced implantation. In cyclic rats treated with centchroman at intervals of 168 h and mated with males of proven fertility, implantation was prevented only when the interval between centchroman treatment and nidatory oestrogen secretion was less than 120 h. None of the females conceived when treated regularly at intervals of 120 h during exposure to fertile males. Discontinuation of treatment resulted in the occurrence of normal implantations in rats that mated 48 h or later after the last dose of centchroman, since in these animals the interval between anti-oestrogen treatment and nidatory oestrogen secretion was greater than 120 h. These findings suggest that the duration of the anti-implantation action of a single oral antifertility dose of centchroman in rats is about 120 h. Recovery of normal blastocysts from rats treated continuously with this dose of centchroman at these intervals suggests lack of significant effect on follicular maturation, ovulation, fertilization, preimplantation development or mating behaviour.(ABSTRACT TRUNCATED AT 250 WORDS)  (+info)

Centchroman is a synthetic, non-steroidal selective estrogen receptor modulator (SERM) that was developed for use as a potential contraceptive. It works by binding to estrogen receptors and inhibiting the action of estrogen in certain tissues, such as the uterus and ovaries, while having no effect or agonistic effects in other tissues, such as bone and liver.

Centchroman was investigated for its potential to prevent ovulation, thicken cervical mucus, and alter endometrial receptivity, thereby preventing pregnancy. However, it has not been approved for use as a contraceptive or for any other medical indication in many countries, including the United States.

Like other SERMs, centchroman may have both beneficial and adverse effects on various organs and systems of the body, depending on the specific tissue and context. Therefore, further research is needed to fully understand its potential therapeutic uses and risks.

Delayed embryo implantation is a medical condition that occurs when the fertilized egg (embryo) does not attach to the uterine lining (endometrium) within the expected time frame, typically within 7-10 days after ovulation. In delayed implantation, the embryo may take longer than usual to implant, which can result in a prolonged menstrual cycle or irregular bleeding.

There are several possible reasons for delayed implantation, including hormonal imbalances, uterine abnormalities, immune system dysfunction, and chromosomal abnormalities in the embryo. In some cases, delayed implantation may be a sign of infertility or recurrent pregnancy loss.

Diagnosis of delayed implantation typically involves monitoring hormone levels and tracking menstrual cycles. Imaging tests such as ultrasound or hysteroscopy may also be used to assess the uterine lining and detect any abnormalities that could be contributing to the delay in implantation.

Treatment for delayed implantation depends on the underlying cause. Hormonal therapies, medications to suppress the immune system, or surgery to correct uterine abnormalities may be recommended in some cases. In vitro fertilization (IVF) with embryo transfer may also be considered as a treatment option for couples experiencing delayed implantation and infertility.

The nictitating membrane, also known as the third eyelid, is a thin, translucent or transparent partial eyelid located in the inner corner of the eye in many animals. It moves horizontally across the eye and serves to clean, moisten, and protect the eye, especially during sleep or when the animal's eyes are closed. This membrane is present in some birds, reptiles, amphibians, and mammals, including seals and dogs, but is typically absent or poorly developed in primates, including humans.

Bronchial spasm refers to a sudden constriction or tightening of the muscles in the bronchial tubes, which are the airways that lead to the lungs. This constriction can cause symptoms such as coughing, wheezing, and difficulty breathing. Bronchial spasm is often associated with respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), and bronchitis. In these conditions, the airways are sensitive to various triggers such as allergens, irritants, or infections, which can cause the muscles in the airways to contract and narrow. This can make it difficult for air to flow in and out of the lungs, leading to symptoms such as shortness of breath, wheezing, and coughing. Bronchial spasm can be treated with medications that help to relax the muscles in the airways and open up the airways, such as bronchodilators and anti-inflammatory drugs.

"Centchroman". CSIR-CDRI. Archived from the original on 14 February 2019. Retrieved 25 September 2018. Lal J (April 2010). " ... Nigam M, Ranjan V, Srivastava S, Sharma R, Balapure AK (March 2008). "Centchroman induces G0/G1 arrest and caspase-dependent ... Ormeloxifene, also known as centchroman, is one of the selective estrogen receptor modulators, or SERMs, a class of medication ... Levormeloxifene Gupta RC, Paliwal JK, Nityanand S, Asthana OP, Lal J (November 1995). "Centchroman: a new non-steroidal oral ...
"Centchroman". Reproductive Health Online. 2003. Retrieved 2009-08-29. Nelson AL, Cwiak C (2011). "Combined oral contraceptives ... Ormeloxifene is a selective estrogen receptor modulator (SERM). Marketed as Centchroman, Centron, or Saheli, it is pill that is ... 1988). "Results of multicentric trial of Centchroman". In Dhwan B. N., et al. (eds.). Pharmacology for Health in Asia : ... 1990). "Clinical evaluation of Centchroman: a new oral contraceptive". In Puri, Chander P., Van Look, Paul F. A. (eds.). ...
see Combined oral contraceptive pill ยง Role of Placebo Pills Puri V (1988). "Results of multicentric trial of Centchroman". In ... Nityanand S (1990). "Clinical evaluation of Centchroman: a new oral contraceptive". In Puri CP, Van Look PF (eds.). Hormone ...
Dhar A, Srivastava A (June 2007). "Role of centchroman in regression of mastalgia and fibroadenoma". World Journal of Surgery. ...
Centchroman/Ormeloxifene https://www.indiabudget.gov.in/doc/eb/sbe45.pdf[bare URL PDF] cosmic. "CDRI , Home". cdri.res.in. ...
... centchroman MeSH D03.438.150.266 - chromones MeSH D03.438.150.266.300 - cromolyn sodium MeSH D03.438.150.266.450 - flavonoids ... centchroman MeSH D03.830.219.266 - chromones MeSH D03.830.219.266.300 - cromolyn sodium MeSH D03.830.219.266.450 - flavonoids ...
... or centchroman) This set index page lists chemical structure articles associated with the same molecular formula. If an ...
Literature References: Estrogen antagonist; synthetic nonsteroidal postcoital antifertility agent. Pharmacology: V. P. Kamboj et al., Indian J. Exp. Biol. 9, 103 (1971); idem et al., ibid. 15, 1144 (1977). Prepd (not claimed): J. W. Bolger, DE 2329201 (1974 to Riker); idem, US 3822287 (1974 to Rexall); S. Ray et al., J. Med. Chem. 19, 276 (1976). Mechanism of action: M. S. Sankaran, M. R. N. Prasad, Contraception 9, 279 (1974). Clinical pharmacology: R. Vaidya et al., ibid. 1173. Physicochemical properties: R. K. Seth et al., Indian J. Pharm. Sci. 45, 14 (1983). Resolution and stereoselective binding of enantiomers: M. Salman et al., J. Med. Chem. 29, 1801 (1986). Absolute configuration: N. Srivastava et al., Bioorg. Med. Chem. Lett. 6, 1747 (1996). HPLC determn in serum and milk: J. Lal et al., J. Chromatogr. B 658, 193 (1994). Clinical pharmacokinetics: idem et al., Contraception 52, 297 (1995). Toxicity: I. M. Chak et al., Indian J. Exp. Biol. 15, 1159 (1977). Review of clinical experience: ...
"Centchroman". CSIR-CDRI. Archived from the original on 14 February 2019. Retrieved 25 September 2018. Lal J (April 2010). " ... Nigam M, Ranjan V, Srivastava S, Sharma R, Balapure AK (March 2008). "Centchroman induces G0/G1 arrest and caspase-dependent ... Ormeloxifene, also known as centchroman, is one of the selective estrogen receptor modulators, or SERMs, a class of medication ... Levormeloxifene Gupta RC, Paliwal JK, Nityanand S, Asthana OP, Lal J (November 1995). "Centchroman: a new non-steroidal oral ...
Return to Article Details QI initiative to improve utilization of centchroman: a non-steroidal contraceptive Download Download ...
Ormeloxifene (Centchroman). Ormeloxifene, also known as centchroman, belongs to a class of drugs known as selective estrogen ... Sharma N, Gupta A, Jha PK, Rajput P. Mastalgia cured! Randomized trial comparing centchroman to evening primrose oil. The ... Jain BK, Bansal A, Choudhary D, Garg PK, Mohanty D. Centchroman vs tamoxifen for regression of mastalgia: A randomized ... Tejwani PL, Srivastava A, Nerkar H, Dhar A, Hari S, Thulkar S, ... Kumar S. Centchroman regresses mastalgia: a randomized ...
What is normal glucose level? A blood sugar level less than 140 mg/dL (7.8 mmol/L) is normal. A reading of more than 200 mg/dL (11.1 mmol/L) after two hours indicates diabetes. A reading between 140 and 199 mg/dL (7.8 mmol/L and 11.0 mmol/L) indicates prediabetes. What is an alarming glucose level? In general, a blood. ...
Ormeloxifene (a.k.a. Centchroman). Intra-uterine:. IUD (copper or progestogen), IUS (progestogen) ...
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Ormeloxifene (a.k.a. Centchroman). Intra-uterine:. IUD (copper or progestogen), IUS (progestogen) ...
Expected to be: Centchroman / Ormeloxifene Has Been Tried: Yes Lab comments:. Apr 18 2023: Many large molecules including ...
Centchroman 30 mg. Pricing Information. *Min cost19.04. *Avg Cost 21.28. *Max cost 22.4 ...
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RESULTS: Of 120 women who opted for centchroman, continuation rate was 91% at 12 months. There was one case of user failure and ... CONCLUSIONS: Centchroman is safe, effective, has good acceptance, and continuation rate post abortion with infrequent menstrual ... IMPLICATIONS: Centchroman, available in Government scheme for contraception, has good acceptance and continuation rate post ... Following spontaneous/induced abortion, women were offered centchroman, 30-mg tablet twice weekly for first 3 months, then once ...
Centchroman did not cause any consistent pattern of alteration in lipid contents of uterus, cervix and vagina of female rhesus ... Effect of centchroman on lipid metabolism in genital organs of female rhesus monkeys (macaca mulatta) ... Abstract: Effect of Centchroman (3,4-trans-2, 2-dimenthyl-3-phenyl-4-p (B-pyrrolidinoethoxy)-phenyl-7-methoxy chroman)treatment ... of responses in the genital organs may be due to manifestation of estrogenic-cum-antiestrogenic properties of centchroman. ...
Centchroman inhibits proliferation of head and neck cancer cells through the modulation of PI3K/mTOR pathway. Biochem Biophys ...
Sharma N, Gupta A, Jha PK, Rajput P. Mastalgia Cured! Randomized Trial Comparing Centchroman to Evening Primrose Oil. Breast J ... Sharma N, Gupta A, Jha PK, Rajput P. Mastalgia Cured! Randomized Trial Comparing Centchroman to Evening Primrose Oil. Breast J ...
Diindolylmethane Promotes Metabolic Crisis and Enhances the Efficacy of Centchroman in Breast Cancer: A 1H NMR-Based Approach. ...
Saheli contains the molecule Centchroman which instead of using estrogen to prevent pregnancy, blocks the estrogen to do the ...
Ormeloxifene (also known as Centchroman) is a selective oestrogen receptor modulator which is taken one to two times per week. ...
Oral contraceptive pill, Saheli contains a nonsteroidal preparation called centchroman which is taken once a week after an ...
Environment stress include shifting houses or cities, or an acute and sudden change in the weather can cause the periods to become delayed. Infection -infections of the membranes of the brain (meninigitis) or the brain (encephalitis) can affect the hormonal axis. Psychoses - like Schizophrenia, mood disorders or treatment procedures for psychoses like electric convulsive therapy (ECT), or even drugs like antidepressants and antipsychotic drugs are also important causes. Anorexia Nervosa- Anorexia Nervosa is an important psychological condition in which a girl eats too little food - this causes acute weight loss and amenorrhea. When the body does not have enough energy from food, it is unable to produce the hormones necessary for a regular menstrual cycle. Read more... Pseudocyesis - Pseudocyesis is a condition in which a woman believes that she is pregnant and subconsciously suppresses her menstruation. She can also develop other signs of pregnancy like nausea and vomiting, an increase in body ...
Centchroman D3.830.219.240.225 D3.383.663.283.240.225 Centers for Disease Control and Prevention (U.S.) I1.409.137.500.600.650. ...
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Centchroman D3.830.219.240.225 D3.383.663.283.240.225 Centers for Disease Control and Prevention (U.S.) I1.409.137.500.600.650. ...
Centchroman D3.830.219.240.225 D3.383.663.283.240.225 Centers for Disease Control and Prevention (U.S.) I1.409.137.500.600.650. ...
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Centchroman with around 4 million doses of Injectable contraceptive having been administered cumulatively till now; more than ...
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  • Ormeloxifene, also known as centchroman, is one of the selective estrogen receptor modulators, or SERMs, a class of medication which acts on the estrogen receptor. (wikipedia.org)
  • In India, ormeloxifene has been available as birth control since the early 1990s, and it was marketed there under the trade name Saheli, currently available free-of-cost for the women in India as Chhaya (Centchroman). (wikipedia.org)
  • Ormeloxifene (also known as Centchroman) is a selective oestrogen receptor modulator which is taken one to two times per week. (wikidoc.org)
  • Saheli contains the molecule Centchroman which instead of using estrogen to prevent pregnancy, blocks the estrogen to do the same. (homegrown.co.in)
  • Oral contraceptive pill, Saheli contains a nonsteroidal preparation called centchroman which is taken once a week after an initial intake of twice a week dose for three months. (chemistrypage.in)
  • What is centchroman tablet used for? (steadyprintshop.com)
  • Following spontaneous/induced abortion, women were offered centchroman, 30-mg tablet twice weekly for first 3 months, then once weekly with 1 year of follow-up. (bvsalud.org)
  • Since 2018, Centchroman is provided free-of-cost to the women in India by the government under the brand name Chhaya. (wikipedia.org)
  • RESULTS: Of 120 women who opted for centchroman, continuation rate was 91% at 12 months. (bvsalud.org)
  • In India, ormeloxifene has been available as birth control since the early 1990s, and it was marketed there under the trade name Saheli, currently available free-of-cost for the women in India as Chhaya (Centchroman). (wikipedia.org)
  • Since 2018, Centchroman is provided free-of-cost to the women in India by the government under the brand name Chhaya. (wikipedia.org)
  • The current contraceptive basket comprising condoms, combined oral contraceptive pills, emergency contraceptive pills, intrauterine contraceptive device (IUCD) and sterilization is expanded with inclusion of new contraceptives namely Injectable contraceptive MPA (Antara Programme) and Centchroman (Chhaya). (indiancentury.in)