Dental Cementum: The bonelike rigid connective tissue covering the root of a tooth from the cementoenamel junction to the apex and lining the apex of the root canal, also assisting in tooth support by serving as attachment structures for the periodontal ligament. (Jablonski, Dictionary of Dentistry, 1992)Dental Enamel Proteins: The proteins that are part of the dental enamel matrix.Tooth Root: The part of a tooth from the neck to the apex, embedded in the alveolar process and covered with cementum. A root may be single or divided into several branches, usually identified by their relative position, e.g., lingual root or buccal root. Single-rooted teeth include mandibular first and second premolars and the maxillary second premolar teeth. The maxillary first premolar has two roots in most cases. Maxillary molars have three roots. (Jablonski, Dictionary of Dentistry, 1992, p690)Cementogenesis: The formation of DENTAL CEMENTUM, a bone-like material that covers the root of the tooth.Dental Enamel: A hard thin translucent layer of calcified substance which envelops and protects the dentin of the crown of the tooth. It is the hardest substance in the body and is almost entirely composed of calcium salts. Under the microscope, it is composed of thin rods (enamel prisms) held together by cementing substance, and surrounded by an enamel sheath. (From Jablonski, Dictionary of Dentistry, 1992, p286)Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Periodontal Ligament: The fibrous CONNECTIVE TISSUE surrounding the TOOTH ROOT, separating it from and attaching it to the alveolar bone (ALVEOLAR PROCESS).Amelogenin: A major dental enamel-forming protein found in mammals. In humans the protein is encoded by GENES found on both the X CHROMOSOME and the Y CHROMOSOME.Guided Tissue Regeneration, Periodontal: Techniques for enhancing and directing cell growth to repopulate specific parts of the PERIODONTIUM that have been damaged by PERIODONTAL DISEASES; TOOTH DISEASES; or TRAUMA, or to correct TOOTH ABNORMALITIES. Repopulation and repair is achieved by guiding the progenitor cells to reproduce in the desired location by blocking contact with surrounding tissue by use of membranes composed of synthetic or natural material that may include growth inducing factors as well.Molar: The most posterior teeth on either side of the jaw, totaling eight in the deciduous dentition (2 on each side, upper and lower), and usually 12 in the permanent dentition (three on each side, upper and lower). They are grinding teeth, having large crowns and broad chewing surfaces. (Jablonski, Dictionary of Dentistry, 1992, p821)PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Odontogenesis: The process of TOOTH formation. It is divided into several stages including: the dental lamina stage, the bud stage, the cap stage, and the bell stage. Odontogenesis includes the production of tooth enamel (AMELOGENESIS), dentin (DENTINOGENESIS), and dental cementum (CEMENTOGENESIS).Periodicals as Topic: A publication issued at stated, more or less regular, intervals.OdontoblastsBooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Tooth Eruption, Ectopic: An abnormality in the direction of a TOOTH ERUPTION.Tooth: One of a set of bone-like structures in the mouth used for biting and chewing.Diastema: An abnormal opening or fissure between two adjacent teeth.Tooth Germ: The collective tissues from which an entire tooth is formed, including the DENTAL SAC; ENAMEL ORGAN; and DENTAL PAPILLA. (From Jablonski, Dictionary of Dentistry, 1992)Mandible: The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.Body Patterning: The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.Dentition: The teeth collectively in the dental arch. Dentition ordinarily refers to the natural teeth in position in their alveoli. Dentition referring to the deciduous teeth is DENTITION, PRIMARY; to the permanent teeth, DENTITION, PERMANENT. (From Jablonski, Dictionary of Dentistry, 1992)Hydatidiform Mole: Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.Ectoderm: The outer of the three germ layers of an embryo.Calcium Phosphates: Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.Spectroscopy, Fourier Transform Infrared: A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.Amelogenesis: The elaboration of dental enamel by ameloblasts, beginning with its participation in the formation of the dentino-enamel junction to the production of the matrix for the enamel prisms and interprismatic substance. (Jablonski, Dictionary of Dentistry, 1992).Amelogenesis Imperfecta: A clinically and genetically heterogeneous group of hereditary conditions characterized by malformed DENTAL ENAMEL, usually involving DENTAL ENAMEL HYPOPLASIA and/or TOOTH HYPOMINERALIZATION.Minerals: Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.Matrix Metalloproteinase 20: A secreted matrix metalloproteinase that is the predominant proteolytic activity in the enamel matrix. The enzyme has a high specificity for dental enamel matrix protein AMELOGENIN.Photosynthesis: The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide using energy obtained from light rather than from the oxidation of chemical compounds. Photosynthesis comprises two separate processes: the light reactions and the dark reactions. In higher plants; GREEN ALGAE; and CYANOBACTERIA; NADPH and ATP formed by the light reactions drive the dark reactions which result in the fixation of carbon dioxide. (from Oxford Dictionary of Biochemistry and Molecular Biology, 2001)Software Design: Specifications and instructions applied to the software.Plant Leaves: Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)Chlorophyll: Porphyrin derivatives containing magnesium that act to convert light energy in photosynthetic organisms.Light: That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.Carbon Dioxide: A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.Ribulose-Bisphosphate Carboxylase: A carboxy-lyase that plays a key role in photosynthetic carbon assimilation in the CALVIN-BENSON CYCLE by catalyzing the formation of 3-phosphoglycerate from ribulose 1,5-biphosphate and CARBON DIOXIDE. It can also utilize OXYGEN as a substrate to catalyze the synthesis of 2-phosphoglycolate and 3-phosphoglycerate in a process referred to as photorespiration.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Flaveria: A plant genus of the family ASTERACEAE that is used for experiments in molecular genetic studies in plant physiology and development.Plant Transpiration: The loss of water vapor by plants to the atmosphere. It occurs mainly from the leaves through pores (stomata) whose primary function is gas exchange. The water is replaced by a continuous column of water moving upwards from the roots within the xylem vessels. (Concise Dictionary of Biology, 1990)Peer Group: Group composed of associates of same species, approximately the same age, and usually of similar rank or social status.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.Videotape Recording: Recording of visual and sometimes sound signals on magnetic tape.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Peer Review: An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.Television: The transmission and reproduction of transient images of fixed or moving objects. An electronic system of transmitting such images together with sound over a wire or through space by apparatus that converts light and sound into electrical waves and reconverts them into visible light rays and audible sound. (From Webster, 3rd ed)Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)

The root surface in human teeth: a microradiographic study. (1/33)

In an attempt to clarify the nature of the human cemento-dentinal junction, ground sections of incompletely formed and fully formed extracted teeth were prepared and their histology compared with their microradiographic appearances. The results showed that incompletely formed teeth possess distinctive surface layers outside the granular layer of Tomes. The evidence indicates that these layers are of dentinal origin; their presence during development supports previous explanations by the author of the hyaline layer of Hopewell-Smith and of so-called intermediate cementum. The results also indicate that the granular layer of Tomes does not represent the outer limit of root dentine. The relationship of these surface layers to the definitive cementum which is present in fully formed teeth was studied in both young and older patients. From the results it was concluded that cementum formation begins in the more apical region of the teeth at a time when root formation is well advanced, and that it spreads towards the crown rather than in the generally accepted reverse direction.  (+info)

On the configuration of incremental lines in human dentine as revealed by tetracycline labelling. (2/33)

The pattern of tetracycline labelling in dentine was investigated in ground sections of human teeth under visible and ultraviolet light. The tetracycline lines presented different appearances near the enamel-junction region, near the dentine-cementum junction, in the mantle dentine, and in the circumpulpal dentine, depending on whether the mineralization front was linear, globular or linear-globular.  (+info)

The developmental biology of cementum. (3/33)

In conclusion, we have reviewed an extensive literature on early cementogenesis and performed a detailed morphological and molecular analysis to illustrate and verify key issues in the current debate about epithelial and mesenchymal contributions to root cementum. We have demonstrated that prior to cementogenesis, Hertwig's epithelial root sheath disintegrates and dental follicle cells penetrate the epithelial layer to invade the root surface. Our studies confirmed that HERS became disrupted or disintegrated prior to cementum deposition. We visualized how mesenchymal cells from the dental follicle penetrated the HERS bilayer and deposited initial cementum, while immediately adjacent epithelial cells were separated from the root surface by a basal lamina and did not secrete any cementum. Human specimen from the Gottlieb collection indicated that HERS was removed from the root surface prior to cementum deposition. Our in situ hybridization and immolocalization data revealed that both amelogenin mRNAs and enamel proteins were restricted to the crown enamel and were absent from the root surface and from the cervical-most ameloblasts adjacent to the root margin. On Western blots, cementum protein extracts did not cross-react with amelogenin antibodies. Our studies in conjunction with our literature review together confirmed the classical theory of cementum as a dental follicle derived connective tissue that forms subsequent to HERS disintegration.  (+info)

Lesions related to the formation of bone, cartilage or cementum arising in the oral area: a statistical study and review of the literature. (4/33)

This report contains a statistical review of 559 cases of lesions forming hard tissues that were diagnosed by the departments of Clinical Pathophysiology and of Pathology at Tokyo Dental College from 1966 to 2001. Sixteen kinds of lesions which were related to the formation of bone, cartilage or cementum were analysed: osteoma, osteo-chondroma, chondroma, osteoid osteoma, osteoblastoma, ossifying fibroma, cemento-ossifying fibroma, cementifying fibroma, so-called cementoma, cementoblastoma, gigantiform cementoma, periapical cemental dysplasia, osteosarcoma, chondrosarcoma, fibro-osseous lesion, and fibrous dysplasia of bone. The most common lesion was osteoma (203 cases). There is a marked tendency for this condition to occur in females (201 males cases and 358 female cases). The patients' ages ranged from 3 to 84 years, and the mean was 40.1 years old. Lesions with hard tissue formation were observed most frequently in the third decade and in the mandibular molar region.  (+info)

Cementum and periodontal wound healing and regeneration. (5/33)

The extracellular matrix (ECM) of cementum resembles other mineralized tissues in composition; however, its physiology is unique, and it contains molecules that have not been detected in other tissues. Cementum components influence the activities of periodontal cells, and they manifest selectivity toward some periodontal cell types over others. In light of emerging evidence that the ECM determines how cells respond to environmental stimuli, we hypothesize that the local environment of the cementum matrix plays a pivotal role in maintaining the homeostasis of cementum under healthy conditions. The structural integrity and biochemical composition of the cementum matrix are severely compromised in periodontal disease, and the provisional matrix generated during periodontal healing is different from that of cementum. We propose that, for new cementum and attachment formation during periodontal regeneration, the local environment must be conducive for the recruitment and function of cementum-forming cells, and that the wound matrix is favorable for repair rather than regeneration. How cementum components may regulate and participate in cementum regeneration, possible new regenerative therapies using these principles, and models of cementoblastic cells are discussed.  (+info)

Gene therapy of bone morphogenetic protein for periodontal tissue engineering. (6/33)

BACKGROUND: The reconstruction of lost periodontal support including bone, ligament, and cementum is a major goal of therapy. Bone morphogenetic proteins (BMPs) have shown much potential in the regeneration of the periodontium. Limitations of BMP administration to periodontal lesions include need for high-dose bolus delivery, BMP transient biological activity, and low bioavailability of factors at the wound site. Gene transfer offers promise as an alternative treatment strategy to deliver BMPs to periodontal tissues. METHODS: This study utilized ex vivo BMP-7 gene transfer to stimulate tissue engineering of alveolar bone wounds. Syngeneic dermal fibroblasts (SDFs) were transduced ex vivo with adenoviruses encoding either green fluorescent protein (Ad-GFP or control virus), BMP-7 (Ad-BMP-7), or an antagonist of BMP bioactivity, noggin (Ad-noggin). Transduced cells were seeded onto gelatin carriers and then transplanted to large mandibular alveolar bone defects in a rat wound repair model. RESULTS: Ad-noggin treatment tended to inhibit osteogenesis as compared to the control-treated and Ad-BMP-7-treated specimens. The osseous lesions treated by Ad-BMP-7 gene delivery demonstrated rapid chrondrogenesis, with subsequent osteogenesis, cementogenesis and predictable bridging of the periodontal bone defects. CONCLUSION: These results demonstrate the first successful evidence of periodontal tissue engineering using ex vivo gene transfer of BMPs and offers a new approach for repairing periodontal defects.  (+info)

Cementoblast delivery for periodontal tissue engineering. (7/33)

BACKGROUND: Predictable periodontal regeneration following periodontal disease is a major goal of therapy. The objective of this proof of concept investigation was to evaluate the ability of cementoblasts and dental follicle cells to promote periodontal regeneration in a rodent periodontal fenestration model. METHODS: The buccal aspect of the distal root of the first mandibular molar was denuded of its periodontal ligament (PDL), cementum, and superficial dentin through a bony window created bilaterally in 12 athymic rats. Treated defects were divided into three groups: 1) carrier alone (PLGA polymer sponges), 2) carrier + follicle cells, and 3) carrier + cementoblasts. Cultured murine primary follicle cells and immortalized cementoblasts were delivered to the defects via biodegradable PLGA polymer sponges, and mandibulae were retrieved 3 weeks and 6 weeks post-surgery for histological evaluation. In situ hybridization, for gene expression of bone sialoprotein (BSP) and osteocalcin (OCN), and histomorphometric analysis were further done on 3-week specimens. RESULTS: Three weeks after surgery, histology of defects treated with carrier alone indicated PLGA particles, fibrous tissue, and newly formed bone scattered within the defect area. Defects treated with carrier + follicle cells had a similar appearance, but with less formation of bone. In contrast, in defects treated with carrier + cementoblasts, mineralized tissues were noted at the healing site with extension toward the root surface, PDL region, and laterally beyond the buccal plate envelope of bone. No PDL-bone fibrous attachment was observed in any of the groups at this point. In situ hybridization showed that the mineralized tissue formed by cementoblasts gave strong signals for both BSP and OCN genes, confirming its nature as cementum or bone. The changes noted at 3 weeks were also observed at 6 weeks. Cementoblast-treated and carrier alone-treated defects exhibited complete bone bridging and PDL formation, whereas follicle cell-treated defects showed minimal evidence of osteogenesis. No new cementum was formed along the root surface in the above two groups. Cementoblast-treated defects were filled with trabeculated mineralized tissue similar to, but more mature, than that seen at 3 weeks. Furthermore, the PDL region was maintained with well-organized collagen fibers connecting the adjacent bone to a thin layer of cementum-like tissue observed on the root surface. Neoplastic changes were observed at the superficial portions of the implants in two of the 6-week cementoblast-treated specimens, possibly due in part to the SV40-transformed nature of the implanted cell line. CONCLUSIONS: This pilot study demonstrates that cementoblasts have a marked ability to induce mineralization in periodontal wounds when delivered via polymer sponges, while implanted dental follicle cells seem to inhibit periodontal healing. These results confirm the selective behaviors of different cell types in vivo and support the role of cementoblasts as a tool to better understand periodontal regeneration and cementogen-  (+info)

Effect of sustained gene delivery of platelet-derived growth factor or its antagonist (PDGF-1308) on tissue-engineered cementum. (8/33)

BACKGROUND: Cementum, a mineralized tissue lining the tooth root surface, is destroyed during the inflammatory process of periodontitis. Restoration of functional cementum is considered a criterion for successful regeneration of periodontal tissues, including formation of periodontal ligament, cementum, and alveolar bone. Short-term administration of platelet-derived growth factor (PDGF) has been shown to partially regenerate periodontal structures. Nonetheless, the role of PDGF in cementogenesis is not well understood. The aim of the present study was to determine the effect of sustained PDGF gene transfer on cementum formation in an ex vivo ectopic biomineralization model. METHODS: Osteocalcin (OC) promoter-driven SV40 transgenic mice were used to obtain immortalized cementoblasts (OCCM). The OCCM cells were transduced with adenoviruses (Ad) encoding either PDGF-A, an antagonist of PDGF signaling (PDGF-1308), a control virus (green fluorescent protein, GFP), or no treatment (NT). The transduced cells were incorporated into polymer scaffolds and implanted subcutaneously into severe combined immunodeficient (SCID) mice. The implants were harvested at 3 and 6 weeks for histomorphometric analysis of the newly formed mineralized tissues. Northern blot analysis was performed to determine the expression levels of mineral-associated genes including bone sialoprotein (BSP), OC, and osteopontin (OPN) in the cell-implant specimens at 3 and 6 weeks. RESULTS: The results indicated mineralization was significantly reduced in both the Ad/PDGF-A and Ad/PDGF-1308 treated specimens when compared to the NT or Ad/GFP groups at 3 and 6 weeks (P<0.01). In addition, the size of the implants treated with Ad/PDGF-A and Ad/PDGF-1308 was significantly reduced compared to implants from Ad/GFP and NT groups at 3 weeks (P<0.05). At 6 weeks, the size of implants and mineral formation increased in NT, Ad/GFP, and Ad/PDGF-A groups, while the Ad/PDGF-1308 treated implants continued to decrease in size and mineral formation (P<0.01). Northern blot analysis revealed that in the Ad/PDGF-A treated implants OPN was increased, whereas OC gene expression was downregulated at 3 weeks. In the Ad/PDGF-1308 treated implants, BSP, OC, and OPN were all downregulated at 3 weeks. At 3 weeks, the Ad/PDGF-A treated implants contained significantly higher multinucleated giant cell (MNGC) density compared to NT, Ad/GFP, and Ad/PDGF-1308 specimens. The MNGC density in NT, Ad/GFP, and Ad/PDGF-A treated groups reduced over time, while the Ad/PDGF-1308 transduced implants continued to exhibit significantly higher MNGC density compared with the other treatment groups at 6 weeks. CONCLUSIONS: The results showed that continuous exposure to PDGF-A had an inhibitory effect on cementogenesis, possibly via the upregulation of OPN and subsequent enhancement of MNGCs at 3 weeks. On the other hand, Ad/PDGF-1308 inhibited mineralization of tissue-engineered cementum possibly due to the observed downregulation of BSP and OC and a persistence of stimulation of MNGCs. These findings suggest that continuous exogenous delivery of PDGF-A may delay mineral formation induced by cementoblasts, while PDGF is clearly required for mineral neogenesis.  (+info)

*Cementogenesis

... is the formation of cementum, one of the three mineralized substances of a tooth. Cementum covers the roots of ... The cementoblasts then disperse to cover the root dentin area and undergo cementogenesis, laying down cementoid. During the ... For cementogenesis to begin, Hertwig epithelial root sheath (HERS) must fragment. HERS is a collar of epithelial cells derived ... This then stimulates the activation of cementoblasts to begin cementogenesis. The external shape of each root is fully ...

*Index of oral health and dental articles

Cementogenesis • Cementum • Central giant cell granuloma • Central odontogenic fibroma • Central ossifying fibroma • Central ...

*Cementoblastoma

Cementum Cementogenesis Cementoblast Sankari Leena S, Ramakrishnan K (2011). "Benign cementoblastoma". Journal of Oral and ...

*Cementoblast

Cementum Cementogenesis Tooth development Cementoblastoma Ten Cate's Oral Histology, Nanci, Elsevier, 2013, page 207 Luan, X.; ... and whose biological function is cementogenesis, which is the formation of cementum (hard tissue that covers the tooth root). ...

*Enamel matrix derivative

... known as cementogenesis. The presence of acellular cementum acts to signal the development of periodontal ligament fibers, ...

*Epithelial root sheath

... but HERS may be involved in cementogenesis and the secreting of cementum, or that HERS-derived products might be related to ...

*List of MeSH codes (G07)

... cementogenesis MeSH G07.574.500.325.377.750.461 --- dentinogenesis MeSH G07.574.500.325.520 --- sex differentiation MeSH ...
Υπόβαθρο: Η παγκόσμια οικονομική κρίση επηρεάζει τις πολιτικές υγείας παγκοσμίως, ενώ το Ευρωπαϊκό πλαίσιο πολιτικής «Υγεία 2020» επιδιώκει τη δημιουργία βιώσιμων, ισότιμα προσβάσιμων, υψηλής ποιότητας, ασθενοκεντρικών ...
Purpose/Aim: Cementogenesis is a critical step in periodontal tissue regeneration given the essential role of cementum in anchoring teeth to the alveolar bone. This study is designed to achieve integrated cementum formation on the root surfaces of human teeth using growth factor-releasing scaffolds with periodontal ligament stem/progenitor cells (PDLSCs). Materials and methods: Human PDLSCs were sorted by CD146 expression, and characterized using CFU-F assay and induced multi-lineage differentiation. Polycaprolactone scaffolds were fabricated using 3D printing, embedded with poly(lactic-co-glycolic acids) (PLGA) microspheres encapsulating connective tissue growth factor (CTGF), bone morphogenetic protein-2 (BMP-2), or bone morphogenetic protein-7 (BMP-7). After removing cementum on…. ...
The speed of degradation of Syn Oss = Rate of bone formation Degrades fully within 6 - 12 months, depending upon regeneration dynamics of the patient.. Syn Oss is indicated for filling of mostly non-stressed, multiple bone defects of the skeleton. The augmentation site should be free of inflamation, soft tissue, granulation tissue & infection. Indications include : Post extraction ridge ...
Background. Stem cells have contributed to the development of tissue-engineered-based regenerative periodontal therapies. In order to find the best stem cell sources for such therapies, the biologic properties of stem cells isolated from periodontal ligaments (PDL) of deciduous (DePDLSC) and permanent (PePDLSC) teeth were comparatively evaluated. Methods. PDL stem cells were isolated from six sound fully erupted premolars and six deciduous canines of healthy subjects. In vitro biologic characteristics such as colony formation, viability, stem cell marker identification and osteogenic differentiation (using alkaline phosphatase analysis and Alizarin red staining) were comparatively assessed using one-way ANOVA and post hoc Tukey tests using SPSS 13 ...
Meanwhile, since he was sedated for the ultrasound, the vets took a closer look at Fitz teeth. His gums were receding so much that the roots of two teeth were almost entirely exposed. One had a huge tartar cap on it that was so hard it took a Dremel to drill through it and break it apart. (Weve since heard this abnormal tartar buildup called a "cementoblast.") As the vet drilled into the cementoblast, the bit went right through what should have been tooth behind it and into dead bone. The infection in the tooth had moved into the bone and caused some decay. A second infected incisor was also removed, but there was no bone involvement in relation to that one. That left one more incisor with most of the root exposed, but it still seemed to be firmly in place and not infected, so it was left alone for the time being ...
Molecules involved in periodontal regeneration, Cytokines, Growth factors, Adhesion molecules, Fibroblast growth factor-1 and -2, Bone morphogenetic proteins, Insulin-like growth factor-I and II, Platelet-derived growth factor.
Fu, J.-H.,Wang, H.-L. (2013-04-05). Clinical Correlate: Periodontal Regeneration. Mineralized Tissues in Oral and Craniofacial Science: Biological Principles and Clinical Correlates : 201-205. [email protected] Repository. https://doi.org/10.1002/9781118704868.ch23 ...
TY - JOUR. T1 - Effect of platelet-rich plasma on the healing of intrabony defects treated with beta tricalcium phosphate and expanded polytetrafluoroethylene membranes. AU - Döri, Ferenc. AU - Huszár, Tamás. AU - Nikolidakis, Dimitris. AU - Tihanyi, Dora. AU - Horváth, Attila. AU - Arweiler, Nicole B.. AU - Gera, I.. AU - Sculean, Anton. PY - 2008/4. Y1 - 2008/4. N2 - Background: Regenerative periodontal therapy using platelet-rich plasma (PRP) and different types of bone substitutes with or without guided tissue regeneration (GTR) has been proposed as a modality to enhance the outcome of regenerative surgery. However, there are limited data from controlled clinical studies evaluating the effect of PRP on the healing of deep intrabony defects treated with a combination of bone substitutes and GTR. The aim of this study was to clinically evaluate the effect of PRP on the healing of deep intrabony defects treated with beta tricalcium phosphate (β-TCP) and GTR by means of a non-bioresorbable ...
There are three hard tissues that comprise human teeth: enamel, dentin and cementum. The majority of the tooth structure is formed from dentin, and the enamel serves as the superficial layer of the crown while the cementum serves to cover the root. In the mid-1990s, however, it was discovered that a very thin layer of enamel actually exists between the dentin and cementum on the roots of adult human teeth. This led researchers to conclude that enamel matrix proteins (or EMPs) laid down by Hertwigs epithelial root sheath serve as precursors to acellular cementum during its formation, known as cementogenesis.[1] The presence of acellular cementum acts to signal the development of periodontal ligament fibers, followed by new alveolar bone, thus leading to the formation of the tissues of the periodontium.[2]. ...
Regenics bone regeneration synthetic materials regenics bone regeneration help regeneration of bone synthetic materials materials regenics synthetic
0033] In a particular embodiment of the present invention, the concentration of the growth and differentiation factors incorporated in cell-guiding scaffolds can be adjusted according to the release kinetics influenced by the scaffold material, the presence of the intermediate binding agent (protein, glycoprotein, glycosaminoglycan, polysaccharide) and the type of the binding (covalent crosslinking or otherwise). According to a specific aspect of the embodiment, basic fibroblast growth factor (bFGF) concentration varies in the range of 1 μg/ml-1000 μg/ml, and more preferably between 5 μg/ml-500 μg/ml, and still more preferably between 10 μg/ml-300 μg/ml. In a multicenter randomized double-blinded clinical study, the bFGF application to periodontal defects at concentration ranging between 300 μg/ml-3000 μg/ml resulted with a significant attachment gain and 2-fold bone height gain after 36 months postoperatively (Kitamura et al. PLoS ONE. 2008; 3(7):e2611.) According to another aspect of ...
Principal Investigator:TANAKA SAORI, Project Period (FY):2013-04-01 - 2016-03-31, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Conservative dentistry
Hyaluronic acid (HA) is a natural-non sulphated high molecular weight glycosaminoglycan that forms a critical component of the extracellular matrix and contributes significantly to tissue hydrodynamics, cell migration and proliferation. The use of HA
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
1PC3: Crystal structure of M tuberculosis ABC phosphate transport receptor: specificity and charge compensation dominated by ion-dipole interactions.
Looking for online definition of tip of tooth root in the Medical Dictionary? tip of tooth root explanation free. What is tip of tooth root? Meaning of tip of tooth root medical term. What does tip of tooth root mean?
The use of guided tissue regeneration procedures has intensified the need to determine the types and quantity of tissues formed in healing. Regeneration is differentiated from new attachment in one basic, but very important manner: alveolar bone formation with new inserted periodontal fibers in new cementum is a prerequisite for the regeneration of periodontium (4-6). Areas of new cementum deposition without adjacent bone, and vice-versa, and areas of ankylosis, for example, do not satisfy the criteria for regeneration (7). Furthermore, recent advances in the understanding of functions and mechanisms of action of growth factors to regulate the healing process have provided evidence that these proteins may serve as therapeutic agents to enhance the healing of periodontal wounds (8-11). Sigurdsson et al. (12) found a significant enhancement in periodontal regeneration using the rhBMP-2 in dog models. They described limited root resorption and ankylosis generally limited immediately apical to the ...
The case shown here is of a 46 year-old female patient diagnosed with a severe generalised Chronic Periodontitis. The x-rays revealed the presence of several angular bony defects, known to progress quickly if left untreated, leading to tooth loss.. ...
Normal Periodontium and its components including gingiva, periodontal ligament, cementum, alveolar bone. Formation, classification and functions of these components.
NotesSales, means the sales volume of Tricalcium CitrateRevenue, means the sales value of Tricalcium CitrateThis report studies sales (consumption) of Tricalcium Citrate in Global market, especially in USA, China, Europe,
Periodontal regeneration is now FDA-approved -- for the first time ever. Your periodontist in Florham Park is excited to share the news about the treatment.
Thank you for your interest in spreading the word about The BMJ.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Business Directory for Tricalcium Phosphate Suppliers in Mumbai - Get contact details of Tricalcium Phosphate Manufacturers, Wholesale Tricalcium Phosphate Exporters, Best Tricalcium Phosphate Traders & Distributors Across the Mumbai.
Principal Investigator:Toyoda Kyosuke, Project Period (FY):2015-08-28 - 2017-03-31, Research Category:Grant-in-Aid for Research Activity start-up, Research Field:Periodontology
The report generally describes tricalcium phosphate, examines its uses, production methods, patents. Tricalcium phosphate market situation is overviewed;
A high purity α-tricalcium phosphate ceramic having a superior biocompatibility for use mainly as a bone filler, is produced by shaping a powder material formed by a wet method, followed by sintering it and then cooling at a predetermined rate.
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TY - JOUR. T1 - Reaction of bone to tricalcium phosphate ceramic pellets. AU - Cutright, Duane E.. AU - Bhaskar, Surindar N.. AU - Brady, John M.. AU - Getter, Lee. AU - Posey, William R.. PY - 1972/1/1. Y1 - 1972/1/1. N2 - This study indicates that tricalcium phosphate is well accepted by the tissue and may actually contribute mineral salts for the formation of bone at the site as the ceramic is broken down into granules.. AB - This study indicates that tricalcium phosphate is well accepted by the tissue and may actually contribute mineral salts for the formation of bone at the site as the ceramic is broken down into granules.. UR - http://www.scopus.com/inward/record.url?scp=0015337449&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0015337449&partnerID=8YFLogxK. U2 - 10.1016/0030-4220(72)90457-4. DO - 10.1016/0030-4220(72)90457-4. M3 - Article. C2 - 4502161. AN - SCOPUS:0015337449. VL - 33. SP - 850. EP - 856. JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral ...
Detail of the period when the root sheath cells (blue) secrete enamel matrix proteins. Following formation of the protein matrix on the surface of the mineralizing dentin, cementoblasts (Red) start producing cementum (Light blue) which anchors collagen fibers.. The Next Generation. In the mid 1980s, a revolutionary breakthrough in the basic biology of tooth development took place at the Karolinska Institutes department of Oral Pathology in Stockholm. The discovery revealed a native complex of enamel matrix proteins and the key if not crucial , role they play in the development of tooth-supporting tissues. These enamel related proteins mediate the formation of acellular cementum on the root of the developing tooth, providing a foundation for all of the necessary tissues associated with a functional periodontal attachment.. This groundbreaking discovery has fueled the development of a new generation in periodontal therapy, and makes the recreation of lost tooth support an attainable goal in the ...
Sintering Behavior and Mechanical Properties of Magnesium/β-Tricalcium Phosphate Composites Sintered by Spark Plasma SinteringSintering Behavior and Mechanical Properties of Magnesium/β-Tricalcium Phosphate Composites Sintered by Spark Plasma Sintering ...
The good news is that cementum can repair itself. Cementoblasts - cells in your tooth root - make cementum continuously throughout your life as the old cementum ages and thins. This way your teeth stay firmly embedded in your jawbone.. Your goal is to support this natural repair process, to neatly close off your exposed dentinal tubules with cementum.. Cementum is about 50% hydroxylapatite. Tooth enamel is 90% hydroxylapatite, and bone is 70%. Hydroxylapatite is a calcium phosphate mineral, also known as the bone mineral.. Acid food and drinks dissolve hydroxylapatite, and hence cementum. Enamel begins to demineralize at a pH of 5.5.. Yet another reason to eat a high-alkaline diet! When raw fooders eat too much acidic citrus, it dissolves their tooth enamel. They get sensitive teeth. Watch those oranges and lemons. Juice them, or rinse your mouth after eating.. The other 50% of cementum (the part that isnt calcified hydroxylapatite) is mainly collagen and protein polysaccharides (compounds of ...
Research Report on EMEA (Europe, Middle East and Africa) Tricalcium Phosphate (TCP) Market Report 2017. The Report includes market price, demand, trends, size, Share, Growth, Forecast, Analysis & Overview.
In this study, DNA analyses were employed to verify the identity of six morphologically similar species that occur in the coastal waters of Taiwan: the black seabream complex (Acanthopagrus latus, Acanthopagrus schlegelii, Acanthopagrus sivicolus, Acanthopagrus taiwanensis, Acanthopagrus chinshira and Acanthopagrus pacificus). Amplified fragment‐length polymorphism (AFLP) analyses clearly distinguished the same six species that are morphologically diagnosable based on subtle differences in scale counts and anal‐fin colouration. In contrast, mitochondrial DNA analyses based on cytochrome b gene sequences did not distinguish individuals of A. schlegelii and A. sivicolus, reflecting either historical introgression or recent speciation and incomplete sorting of their mitochondrial lineages. Phylogenetic relationships among these six north‐west Pacific Ocean species of Acanthopagrus analysed using AFLP data were consistent with scale rows above the lateral line (TRac), sperm ultrastructure and ...
Objective: To evaluate the kinetics of bone formation of Pool 7 EMD, by concentration, on the amount of marrow formation and study factors relating to angiogenesis associated with EMD-induced bone formation. Methods: Fractionated commercial Emdogain® (EMD) was obtained from Straumann International. 60 CDI 7 day old outbred mice were injected using 50 μl aliquots of 10 µg EMD, 10 µg Pool 7 EMD, 2 µg TGF-β (positive control) or phosphate buffered saline (PBS, negative control) delivered in a calvarial injection model. Injections were done for 5 consecutive days. The animals were sacrificed on days 6, 8, 12, 16 and 21 with 6 animals per factor for each time point and were prepared for histological evaluation. Nikon NIS Elements software was used to analyze vascular growth and new bone formation over the five time intervals at 20x magnification. Immunocytochemistry (IHC) was used to identify the kinetics of osteogenesis by evaluating the osteoblast transcription factor Osterix, and the ...
Tissue sections showed that the replanted tooth was surrounded by newly formed, functional periodontal ligament fibres and new cementum, the essential ingredients of a healthy tooth attachment. In contrast, tooth molars that were replanted without new stem/progenitor cells were either lost or loosely attached and were resorbed, the scientists found. The study, published in an online issue of the journal Tissue Engineering, was funded through a grant by the National Institutes of Health. The natural surface of the tooth played an essential role in the study. To verify that the ligament was formed by the transplanted stem cells and not by the animals own cells, stem cells were labelled with green fluorescent protein prior to seeding them on the molars and re-inserting the teeth into the animals mouth. According to Tom Diekwisch, director of the Brodie Laboratory and senior author on the paper, this is the first progenitor cell-based regeneration of a complete periodontal ligament in which a ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Results of the treatment of the marginal periodontium inflammation with the use of diode laser prior to orthopedic rehabilitation
Tricalcium Citrate Market size demand is mainly driven by growth in applications across industries, such as food & beverage, healthcare and personal care.
List View Map View 3560Diego A. Adrianzen Herrera, MDDiegoA.Adrianzen HerrerafalseUVM Medical Group/Center51Cancer (Medical Oncology), Hematology802-8

Cementogenesis - WikipediaCementogenesis - Wikipedia

Cementogenesis is the formation of cementum, one of the three mineralized substances of a tooth. Cementum covers the roots of ... The cementoblasts then disperse to cover the root dentin area and undergo cementogenesis, laying down cementoid. During the ... For cementogenesis to begin, Hertwig epithelial root sheath (HERS) must fragment. HERS is a collar of epithelial cells derived ... This then stimulates the activation of cementoblasts to begin cementogenesis. The external shape of each root is fully ...
more infohttps://en.wikipedia.org/wiki/Cementogenesis

KAKEN - Research Projects | Development of poiodontal regenerative medicine that based on molecular mechanism of cementogenesis...KAKEN - Research Projects | Development of poiodontal regenerative medicine that based on molecular mechanism of cementogenesis...

Journal Article] Experimental Model for Cementogenesis using Dental Follicle2003. *. Author(s). K.Handa, M.Saito, A.Tsunoda, S. ... Transplantation study of the dental follicle provides a useful model for investigating molecular mechanisms of cementogenesis. ... Development of poiodontal regenerative medicine that based on molecular mechanism of cementogenesis.. Research Project ...
more infohttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390580/

Hertwigs Epithelial Root Sheath Fate during Initial Cellular Cementogenesis in Rat Molars : HUSCAPHertwig's Epithelial Root Sheath Fate during Initial Cellular Cementogenesis in Rat Molars : HUSCAP

Hertwigs Epithelial Root Sheath Fate during Initial Cellular Cementogenesis in Rat Molars. Files in This Item: A20_48_15006. ... To elucidate the fate of the epithelial root sheath during initial cellular cementogenesis, we examined developing maxillary ... Hertwigs Epithelial Root Sheath Fate during Initial Cellular Cementogenesis in Rat Molars. ... where initial cellular cementogenesis begins. After fragmentation of the epithelial sheath, many keratin-positive epithelial ...
more infohttps://eprints.lib.hokudai.ac.jp/dspace/handle/2115/72272

Enamel matrix derivative - WikipediaEnamel matrix derivative - Wikipedia

Discovery of EMPs role in cementogenesis[edit]. There are three hard tissues that comprise human teeth: enamel, dentin and ... known as cementogenesis.[1] The presence of acellular cementum acts to signal the development of periodontal ligament fibers, ...
more infohttps://en.wikipedia.org/wiki/Enamel_matrix_derivative

Index of oral health and dental articles - WikipediaIndex of oral health and dental articles - Wikipedia

Cementogenesis • Cementum • Central giant cell granuloma • Central odontogenic fibroma • Central ossifying fibroma • Central ...
more infohttps://en.wikipedia.org/wiki/Index_of_oral_health_and_dental_articles

Cementum - WikipediaCementum - Wikipedia

Main article: Cementogenesis. Cementum is secreted by cells called cementoblasts within the root of the tooth and is thickest ...
more infohttps://en.wikipedia.org/wiki/Cementum

Free Dentistry Flashcards about PeriodontologyFree Dentistry Flashcards about Periodontology

Cementogenesis. the formation of cementum. Cementoid. the most recent uncalcified layer covering the surface of cementum. ...
more infohttps://www.studystack.com/flashcard-1823782

Fate of HERS during tooth root development.  - PubMed - NCBIFate of HERS during tooth root development. - PubMed - NCBI

... a few are embedded into the cementum during cementogenesis (N, indicated by arrow). Dental mesenchymal cells are detectable ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/19576204?dopt=Abstract

9780867154290: Oral Cells and Tissues - AbeBooks - Philias R. Garant: 08671542929780867154290: Oral Cells and Tissues - AbeBooks - Philias R. Garant: 0867154292

7 Root Formation and Cementogenesis 8 Bone 9 Salivary Glands 10 Oral Somatosensory Systems 11 Muscle 12 Cartilage and ...
more infohttps://www.abebooks.com/9780867154290/Oral-Cells-Tissues-Philias-Garant-0867154292/plp

Current knowledge of tooth development: patterning and mineralization of the murine dentition - Catón - 2009 - Journal of...Current knowledge of tooth development: patterning and mineralization of the murine dentition - Catón - 2009 - Journal of...

... has been shown to have a role in the upregulation of osteopontin in cementogenesis via the MAPK pathway (Boabaid et al. 2004). ... a candidate signaling molecule during cementogenesis. J Periodontol 75, 1126-1136. *CrossRef , ...
more infohttp://onlinelibrary.wiley.com/doi/10.1111/j.1469-7580.2008.01014.x/full

Foundations of clinical practice - Flashcards in University DentistryFoundations of clinical practice - Flashcards in University Dentistry

Copyright Get Revising 2018 all rights reserved. Get Revising is one of the trading names of The Student Room Group Ltd. Register Number: 04666380 (England and Wales), VAT No. 806 8067 22 Registered office: International House, Queens Road, Brighton, BN1 3XE ...
more infohttps://getrevising.co.uk/revision-tests/foundations-of-clinical-practice

Draft:Human teeth - WikiversityDraft:Human teeth - Wikiversity

Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and ... "Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis". International Journal of Oral ...
more infohttps://en.wikiversity.org/wiki/Draft:Human_teeth

Bone Morphogenetic Proteins: From Local to Systemic Therapeutics BuchBone Morphogenetic Proteins: From Local to Systemic Therapeutics Buch

Induction of cementogenesis and periodontal ligament regeneration by the bone morphogenetic proteins.- Control of bone mass by ...
more infohttps://www.weltbild.de/artikel/buch/bone-morphogenetic-proteins-from-local-to-systemic_14925366-1

Frontiers | Immunophenotyping Reveals the Diversity of Human Dental Pulp Mesenchymal Stromal Cells In vivo and Their Evolution...Frontiers | Immunophenotyping Reveals the Diversity of Human Dental Pulp Mesenchymal Stromal Cells In vivo and Their Evolution...

2014). Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis. Int. J. Oral Sci. 7, 27-41 ...
more infohttps://www.frontiersin.org/articles/10.3389/fphys.2016.00512/full

Characterization of the apical bridge barrier formed following amelogenin apexification | Springer for Research & DevelopmentCharacterization of the apical bridge barrier formed following amelogenin apexification | Springer for Research & Development

Leucine-rich amelogenin peptide: a candidate signaling molecule during cementogenesis. J Periodontol. 2004;75(8):1126-36. ...
more infohttps://rd.springer.com/article/10.1186%2Fs12903-018-0641-0

Paper: Bmp-Wnt Interaction Determines Dental Epithelia Cytodifferentiation through Regulation of EMT (AADR Annual Meeting ...Paper: Bmp-Wnt Interaction Determines Dental Epithelia Cytodifferentiation through Regulation of EMT (AADR Annual Meeting ...

Notably, simultaneous β-catenin knockout rescued ectopic cementogenesis caused by Bmpr1a knockout by inhibiting EMT; while ... this study provided the direct in vivo evidences for epithelia-originated cementogenesis through EMT. ... simultaneous Wnt1 over-expression advanced Bmpr1a knockout-induced ectopic cementogenesis by further promoting EMT. Conclusions ...
more infohttp://www-personal.umich.edu/~sbayne/DMG/DMG-Publications/IADR-AADR-Meeting-Program-Books/2012-AADR-Tampa/2012-AADR-Tampa-CD/AADR12/Paper156170.html

JoVE | Peer Reviewed Scientific Video Journal - Methods and ProtocolsJoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

PDL-derived cells (PDLCs) express both osteo/cementogenesis and teno/ligamentogenesis genes. However, an efficient method to ...
more infohttps://www.jove.com/visualize?author=Simon%20D%20Tran%20

Patent US7621963 - Composite bone graft material - Google PatentsPatent US7621963 - Composite bone graft material - Google Patents

Nagaishi, The effect of various implant materials on cementogenesis, Nippon Shishubyo Gakkai Kaishi, 31(2):551-572 (1989).. ...
more infohttp://www.google.ca/patents/US7621963
  • These are the lacunae of the former cementocytes, collagen-producing cells that become entrapped in the extracellular matrix they excrete during cementogenesis. (intarch.ac.uk)
  • Transplantation study of the dental follicle provides a useful model for investigating molecular mechanisms of cementogenesis. (nii.ac.jp)
  • PDL-derived cells (PDLCs) express both osteo/cementogenesis and teno/ligamentogenesis genes. (jove.com)
  • Cementum-forming cells (cementoblasts) are known to be differentiated from periodontal-lineage mesenchymal stem cells (MSCs), which are derived from the dental follicle (DF) in developing tissues and the periodontal ligament (PDL) in adult tissues, but the periodontal-lineage MSC type that is optimal for inducing de novo cementogenesis remains unidentified, as does the method to isolate these cells from harvested tissues. (nih.gov)