Glycoside Hydrolases
Cellulose
Cellulose 1,4-beta-Cellobiosidase
Cellulose, Oxidized
Cellulase
Gluconacetobacter xylinus
Interleukin-1beta
Electrophoresis, Cellulose Acetate
Carboxymethylcellulose Sodium
beta 2-Microglobulin
Cellulases
Cellobiose
Glucosyltransferases
Trichoderma
Microfibrils
Receptors, Adrenergic, beta
Integrin beta3
Pectins
Lignin
Methylcellulose
Transforming Growth Factor beta
Cell Wall
Acetobacter
Clostridium thermocellum
Dietary Fiber
beta-Glucosidase
Molecular Sequence Data
Integrin alpha5beta1
Clostridium
Integrin beta4
Excipients
Cellulosomes
Glucans
Integrin alpha6beta4
Integrin beta Chains
beta 2-Glycoprotein I
Base Sequence
Integrin alpha4beta1
Polysaccharides
Dextrins
Integrin alpha2beta1
Receptors, Adrenergic, beta-2
Clostridium cellulolyticum
RNA, Messenger
Fermentation
Clostridium cellulovorans
Tablets
Integrins
Peptococcaceae
Cells, Cultured
Interleukin-1
Antigens, CD29
Integrin alpha6beta1
Psyllium
Cloning, Molecular
Glycoside hydrolases are a class of enzymes that catalyze the hydrolysis of glycosidic bonds found in various substrates such as polysaccharides, oligosaccharides, and glycoproteins. These enzymes break down complex carbohydrates into simpler sugars by cleaving the glycosidic linkages that connect monosaccharide units.
Glycoside hydrolases are classified based on their mechanism of action and the type of glycosidic bond they hydrolyze. The classification system is maintained by the International Union of Biochemistry and Molecular Biology (IUBMB). Each enzyme in this class is assigned a unique Enzyme Commission (EC) number, which reflects its specificity towards the substrate and the type of reaction it catalyzes.
These enzymes have various applications in different industries, including food processing, biofuel production, pulp and paper manufacturing, and biomedical research. In medicine, glycoside hydrolases are used to diagnose and monitor certain medical conditions, such as carbohydrate-deficient glycoprotein syndrome, a rare inherited disorder affecting the structure of glycoproteins.
Cellulose is a complex carbohydrate that is the main structural component of the cell walls of green plants, many algae, and some fungi. It is a polysaccharide consisting of long chains of beta-glucose molecules linked together by beta-1,4 glycosidic bonds. Cellulose is insoluble in water and most organic solvents, and it is resistant to digestion by humans and non-ruminant animals due to the lack of cellulase enzymes in their digestive systems. However, ruminants such as cows and sheep can digest cellulose with the help of microbes in their rumen that produce cellulase.
Cellulose has many industrial applications, including the production of paper, textiles, and building materials. It is also used as a source of dietary fiber in human food and animal feed. Cellulose-based materials are being explored for use in biomedical applications such as tissue engineering and drug delivery due to their biocompatibility and mechanical properties.
Cellulose 1,4-beta-Cellobiosidase is an enzyme that catalyzes the hydrolysis of cellulose, a complex carbohydrate and the main structural component of plant cell walls, into simpler sugars. Specifically, this enzyme breaks down cellulose by cleaving the 1,4-beta-glycosidic bonds between the cellobiose units that make up the cellulose polymer, releasing individual cellobiose molecules (disaccharides consisting of two glucose molecules). This enzyme is also known as cellobiohydrolase or beta-1,4-D-glucan cellobiohydrolase. It plays a crucial role in the natural breakdown of plant material and is widely used in various industrial applications, such as biofuel production and pulp and paper manufacturing.
Oxidized cellulose is a type of modified cellulose that has undergone oxidation, resulting in the introduction of functional groups such as carboxylic acid or aldehyde groups along the cellulose chain. This process can alter the physical and chemical properties of cellulose, making it more soluble in water and capable of forming gels or films.
Oxidized cellulose is used in a variety of applications, including as a wound dressing material, where it can help to promote healing by providing a moist environment that supports tissue regeneration. It can also be used as a thickening or stabilizing agent in food and cosmetic products, or as a component in the manufacture of specialized papers and textiles.
Cellulase is a type of enzyme that breaks down cellulose, which is a complex carbohydrate and the main structural component of plant cell walls. Cellulases are produced by certain bacteria, fungi, and protozoans, and are used in various industrial applications such as biofuel production, food processing, and textile manufacturing. In the human body, there are no known physiological roles for cellulases, as humans do not produce these enzymes and cannot digest cellulose.
*Gluconacetobacter xylinus*, also known as *Acetobacter xylinum*, is a gram-negative, acetic acid-producing bacterium that is commonly found in fermenting fruits, vegetables, and other plant materials. It is an obligate aerobe, which means it requires oxygen to grow. This bacterium is well-known for its ability to produce cellulose, a complex carbohydrate, as a major component of its extracellular matrix. The cellulose produced by *G. xylinus* is pure and highly crystalline, making it an attractive material for various industrial applications, including the production of biodegradable plastics, nanocomposites, and medical materials. In the medical field, the cellulose produced by this bacterium has been studied for its potential use in wound healing, tissue engineering, and drug delivery systems.
Interleukin-1 beta (IL-1β) is a member of the interleukin-1 cytokine family and is primarily produced by activated macrophages in response to inflammatory stimuli. It is a crucial mediator of the innate immune response and plays a key role in the regulation of various biological processes, including cell proliferation, differentiation, and apoptosis. IL-1β is involved in the pathogenesis of several inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis. It exerts its effects by binding to the interleukin-1 receptor, which triggers a signaling cascade that leads to the activation of various transcription factors and the expression of target genes.
Electrophoresis, cellulose acetate is a laboratory technique used to separate and analyze proteins or other charged molecules based on their size and charge. The sample is applied to a sheet of cellulose acetate, a type of porous plastic film, and an electric field is applied. The proteins migrate through the film towards the electrode with the opposite charge, with smaller and more negatively charged molecules moving faster than larger and less negatively charged ones. This allows for the separation and identification of different protein components in a mixture. It is a simple and rapid method for routine protein separations and is commonly used in biochemistry and molecular biology research.
Carboxymethylcellulose sodium is a type of cellulose derivative that is widely used in the medical and pharmaceutical fields as an excipient or a drug delivery agent. It is a white, odorless powder with good water solubility and forms a clear, viscous solution.
Chemically, carboxymethylcellulose sodium is produced by reacting cellulose, which is derived from plant sources such as wood or cotton, with sodium hydroxide and chloroacetic acid. This reaction introduces carboxymethyl groups (-CH2COO-) to the cellulose molecule, making it more soluble in water and providing negative charges that can interact with positively charged ions or drugs.
In medical applications, carboxymethylcellulose sodium is used as a thickening agent, binder, disintegrant, and suspending agent in various pharmaceutical formulations such as tablets, capsules, liquids, and semisolids. It can also be used as a lubricant in the manufacture of tablets and capsules to facilitate their ejection from molds or dies.
Carboxymethylcellulose sodium has been shown to have good biocompatibility and low toxicity, making it a safe and effective excipient for use in medical and pharmaceutical applications. However, like any other excipient, it should be used with caution and in appropriate amounts to avoid any adverse effects or interactions with the active ingredients of the drug product.
Beta-2 microglobulin (β2M) is a small protein that is a component of the major histocompatibility complex class I molecule, which plays a crucial role in the immune system. It is found on the surface of almost all nucleated cells in the body and is involved in presenting intracellular peptides to T-cells for immune surveillance.
β2M is produced at a relatively constant rate by cells throughout the body and is freely filtered by the glomeruli in the kidneys. Under normal circumstances, most of the filtrated β2M is reabsorbed and catabolized in the proximal tubules of the nephrons. However, when the glomerular filtration rate (GFR) is decreased, as in chronic kidney disease (CKD), the reabsorption capacity of the proximal tubules becomes overwhelmed, leading to increased levels of β2M in the blood and its subsequent appearance in the urine.
Elevated serum and urinary β2M levels have been associated with various clinical conditions, such as CKD, multiple myeloma, autoimmune disorders, and certain infectious diseases. Measuring β2M concentrations can provide valuable information for diagnostic, prognostic, and monitoring purposes in these contexts.
Cellulases are a group of enzymes that break down cellulose, which is a complex carbohydrate and the main structural component of plant cell walls. These enzymes are produced by various organisms, including bacteria, fungi, and protozoa. They play an important role in the natural decomposition process and have various industrial applications, such as in the production of biofuels, paper, and textiles.
Cellulases work by hydrolyzing the beta-1,4 glycosidic bonds between the glucose molecules that make up cellulose, breaking it down into simpler sugars like glucose. This process is known as saccharification. The specific type of cellulase enzyme determines where on the cellulose molecule it will cleave the bond.
There are three main types of cellulases: endoglucanases, exoglucanases, and beta-glucosidases. Endoglucanases randomly attack internal bonds in the amorphous regions of cellulose, creating new chain ends for exoglucanases to act on. Exoglucanases (also known as cellobiohydrolases) cleave cellobiose units from the ends of the cellulose chains, releasing cellobiose or glucose. Beta-glucosidases convert cellobiose into two molecules of glucose, which can then be further metabolized by the organism.
In summary, cellulases are a group of enzymes that break down cellulose into simpler sugars through hydrolysis. They have various industrial applications and play an essential role in natural decomposition processes.
Cellobiose is a disaccharide made up of two molecules of glucose joined by a β-1,4-glycosidic bond. It is formed when cellulose or beta-glucans are hydrolyzed, and it can be further broken down into its component glucose molecules by the action of the enzyme beta-glucosidase. Cellobiose has a sweet taste, but it is not as sweet as sucrose (table sugar). It is used in some industrial processes and may have potential applications in the food industry.
Glucosyltransferases (GTs) are a group of enzymes that catalyze the transfer of a glucose molecule from an activated donor to an acceptor molecule, resulting in the formation of a glycosidic bond. These enzymes play crucial roles in various biological processes, including the biosynthesis of complex carbohydrates, cell wall synthesis, and protein glycosylation. In some cases, GTs can also contribute to bacterial pathogenesis by facilitating the attachment of bacteria to host tissues through the formation of glucans, which are polymers of glucose molecules.
GTs can be classified into several families based on their sequence similarities and catalytic mechanisms. The donor substrates for GTs are typically activated sugars such as UDP-glucose, TDP-glucose, or GDP-glucose, which serve as the source of the glucose moiety that is transferred to the acceptor molecule. The acceptor can be a wide range of molecules, including other sugars, proteins, lipids, or small molecules.
In the context of human health and disease, GTs have been implicated in various pathological conditions, such as cancer, inflammation, and microbial infections. For example, some GTs can modify proteins on the surface of cancer cells, leading to increased cell proliferation, migration, and invasion. Additionally, GTs can contribute to bacterial resistance to antibiotics by modifying the structure of bacterial cell walls or by producing biofilms that protect bacteria from host immune responses and antimicrobial agents.
Overall, Glucosyltransferases are essential enzymes involved in various biological processes, and their dysregulation has been associated with several human diseases. Therefore, understanding the structure, function, and regulation of GTs is crucial for developing novel therapeutic strategies to target these enzymes and treat related pathological conditions.
Trichoderma is a genus of fungi that are commonly found in soil, decaying wood, and other organic matter. While there are many different species of Trichoderma, some of them have been studied for their potential use in various medical and industrial applications. For example, certain Trichoderma species have been shown to have antimicrobial properties and can be used to control plant diseases. Other species are being investigated for their ability to produce enzymes and other compounds that may have industrial or medicinal uses.
However, it's important to note that not all Trichoderma species are beneficial, and some of them can cause infections in humans, particularly in individuals with weakened immune systems. These infections can be difficult to diagnose and treat, as they often involve multiple organ systems and may require aggressive antifungal therapy.
In summary, Trichoderma is a genus of fungi that can have both beneficial and harmful effects on human health, depending on the specific species involved and the context in which they are encountered.
Microfibrils are tiny, thread-like structures that are found in the extracellular matrix (the material that surrounds and supports cells) of many types of biological tissues. They are made up of bundles of long, thin proteins called fibrillins, which are joined together by other proteins such as microfibril-associated glycoproteins (MAGPs).
Microfibrils play an important role in providing structural support and elasticity to tissues. They are particularly abundant in the connective tissue that surrounds blood vessels, where they help to regulate the diameter of the vessels and maintain blood pressure. Microfibrils are also found in the elastic fibers of the lungs, skin, and other tissues, where they contribute to the ability of these tissues to stretch and recoil.
In addition to their structural roles, microfibrils have been shown to play a role in regulating cell behavior and signaling. For example, they can bind to growth factors and other signaling molecules, helping to control the activity of these molecules and influence cellular processes such as proliferation, differentiation, and migration.
Abnormalities in microfibril structure or function have been linked to a number of diseases, including Marfan syndrome, Loeys-Dietz syndrome, and cutis laxa. These conditions are characterized by problems with connective tissue strength and elasticity, which can lead to a range of symptoms such as skeletal abnormalities, cardiovascular disease, and skin fragility.
Adrenergic receptors are a type of G protein-coupled receptor that binds and responds to catecholamines, such as epinephrine (adrenaline) and norepinephrine (noradrenaline). Beta adrenergic receptors (β-adrenergic receptors) are a subtype of adrenergic receptors that include three distinct subclasses: β1, β2, and β3. These receptors are widely distributed throughout the body and play important roles in various physiological functions, including cardiovascular regulation, bronchodilation, lipolysis, and glucose metabolism.
β1-adrenergic receptors are primarily located in the heart and regulate cardiac contractility, chronotropy (heart rate), and relaxation. β2-adrenergic receptors are found in various tissues, including the lungs, vascular smooth muscle, liver, and skeletal muscle. They mediate bronchodilation, vasodilation, glycogenolysis, and lipolysis. β3-adrenergic receptors are mainly expressed in adipose tissue, where they stimulate lipolysis and thermogenesis.
Agonists of β-adrenergic receptors include catecholamines like epinephrine and norepinephrine, as well as synthetic drugs such as dobutamine (a β1-selective agonist) and albuterol (a non-selective β2-agonist). Antagonists of β-adrenergic receptors are commonly used in the treatment of various conditions, including hypertension, angina pectoris, heart failure, and asthma. Examples of β-blockers include metoprolol (a β1-selective antagonist) and carvedilol (a non-selective β-blocker with additional α1-adrenergic receptor blocking activity).
Integrin β3 is a subunit of certain integrin heterodimers, which are transmembrane receptors that mediate cell-cell and cell-extracellular matrix (ECM) adhesion. Integrin β3 combines with either integrin αv (to form the integrin αvβ3) or integrin αIIb (to form the integrin αIIbβ3). These integrins are involved in various cellular processes, including platelet aggregation, angiogenesis, and tumor metastasis.
Integrin αIIbβ3 is primarily expressed on platelets and mediates platelet aggregation by binding to fibrinogen, von Willebrand factor, and other adhesive proteins in the ECM. Integrin αvβ3 is widely expressed in various cell types and participates in diverse functions such as cell migration, proliferation, differentiation, and survival. It binds to a variety of ECM proteins, including fibronectin, vitronectin, and osteopontin, as well as to soluble ligands like vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β).
Dysregulation of integrin β3 has been implicated in several pathological conditions, such as thrombosis, atherosclerosis, tumor metastasis, and inflammatory diseases.
Pectins are complex polysaccharides that are commonly found in the cell walls of plants. In the context of food and nutrition, pectins are often referred to as dietary fiber. They have a variety of important functions within the body, including promoting digestive health by adding bulk to stools and helping to regulate bowel movements.
Pectins are also used in the medical field as a demulcent, which is a substance that forms a soothing film over mucous membranes. This can be helpful in treating conditions such as gastroesophageal reflux disease (GERD) and inflammatory bowel disease (IBD).
In addition to their use in medicine, pectins are widely used in the food industry as a gelling agent, thickener, and stabilizer. They are commonly found in jams, jellies, and other preserved fruits, as well as in baked goods and confectionery products.
Xylans are a type of complex carbohydrate, specifically a hemicellulose, that are found in the cell walls of many plants. They are made up of a backbone of beta-1,4-linked xylose sugar molecules and can be substituted with various side groups such as arabinose, glucuronic acid, and acetyl groups. Xylans are indigestible by humans, but they can be broken down by certain microorganisms in the gut through a process called fermentation, which can produce short-chain fatty acids that have beneficial effects on health.
I'm sorry for any confusion, but "Lignin" is not a medical term. It is a term used in the field of biology and chemistry, particularly in botany and wood science. Lignin is a complex organic polymer that binds cellulose fibers together, providing strength and rigidity to the cell walls of plants. It is a major component of wood and bark.
If you have any medical terms you would like defined or any other questions, please let me know!
Methylcellulose is a semisynthetic, inert, viscous, and tasteless white powder that is soluble in cold water but not in hot water. It is derived from cellulose through the process of methylation. In medical contexts, it is commonly used as a bulk-forming laxative to treat constipation, as well as a lubricant in ophthalmic solutions and a suspending agent in pharmaceuticals.
When mixed with water, methylcellulose forms a gel-like substance that can increase stool volume and promote bowel movements. It is generally considered safe for most individuals, but like any medication or supplement, it should be used under the guidance of a healthcare provider.
Transforming Growth Factor-beta (TGF-β) is a type of cytokine, which is a cell signaling protein involved in the regulation of various cellular processes, including cell growth, differentiation, and apoptosis (programmed cell death). TGF-β plays a critical role in embryonic development, tissue homeostasis, and wound healing. It also has been implicated in several pathological conditions such as fibrosis, cancer, and autoimmune diseases.
TGF-β exists in multiple isoforms (TGF-β1, TGF-β2, and TGF-β3) that are produced by many different cell types, including immune cells, epithelial cells, and fibroblasts. The protein is synthesized as a precursor molecule, which is cleaved to release the active TGF-β peptide. Once activated, TGF-β binds to its receptors on the cell surface, leading to the activation of intracellular signaling pathways that regulate gene expression and cell behavior.
In summary, Transforming Growth Factor-beta (TGF-β) is a multifunctional cytokine involved in various cellular processes, including cell growth, differentiation, apoptosis, embryonic development, tissue homeostasis, and wound healing. It has been implicated in several pathological conditions such as fibrosis, cancer, and autoimmune diseases.
A cell wall is a rigid layer found surrounding the plasma membrane of plant cells, fungi, and many types of bacteria. It provides structural support and protection to the cell, maintains cell shape, and acts as a barrier against external factors such as chemicals and mechanical stress. The composition of the cell wall varies among different species; for example, in plants, it is primarily made up of cellulose, hemicellulose, and pectin, while in bacteria, it is composed of peptidoglycan.
'Acetobacter' is a genus of gram-negative, aerobic, rod-shaped bacteria that are commonly found in various environments such as soil, water, and plant surfaces. They are known for their ability to oxidize alcohols to aldehydes and then to carboxylic acids, particularly the oxidation of ethanol to acetic acid. This property makes them important in the production of vinegar and other fermented foods. Some species of Acetobacter can also cause food spoilage and may be associated with certain human infections, although they are not considered primary human pathogens.
'Clostridium thermocellum' is a type of anaerobic, gram-positive bacterium that is known for its ability to produce cellulases and break down cellulose. It is thermophilic, meaning it grows optimally at higher temperatures, typically between 55-70°C. This organism is of interest in the field of bioenergy because of its potential to convert plant biomass into useful products such as biofuels. However, it's important to note that this bacterium can also produce harmful metabolic byproducts and can be potentially pathogenic to humans.
Dietary fiber, also known as roughage, is the indigestible portion of plant foods that makes up the structural framework of the plants we eat. It is composed of cellulose, hemicellulose, pectin, gums, lignins, and waxes. Dietary fiber can be classified into two categories: soluble and insoluble.
Soluble fiber dissolves in water to form a gel-like material in the gut, which can help slow down digestion, increase feelings of fullness, and lower cholesterol levels. Soluble fiber is found in foods such as oats, barley, fruits, vegetables, legumes, and nuts.
Insoluble fiber does not dissolve in water and passes through the gut intact, helping to add bulk to stools and promote regular bowel movements. Insoluble fiber is found in foods such as whole grains, bran, seeds, and the skins of fruits and vegetables.
Dietary fiber has numerous health benefits, including promoting healthy digestion, preventing constipation, reducing the risk of heart disease, controlling blood sugar levels, and aiding in weight management. The recommended daily intake of dietary fiber is 25-38 grams per day for adults, depending on age and gender.
Beta-glucosidase is an enzyme that breaks down certain types of complex sugars, specifically those that contain a beta-glycosidic bond. This enzyme is found in various organisms, including humans, and plays a role in the digestion of some carbohydrates, such as cellulose and other plant-based materials.
In the human body, beta-glucosidase is produced by the lysosomes, which are membrane-bound organelles found within cells that help break down and recycle various biological molecules. Beta-glucosidase is involved in the breakdown of glycolipids and gangliosides, which are complex lipids that contain sugar molecules.
Deficiencies in beta-glucosidase activity can lead to certain genetic disorders, such as Gaucher disease, in which there is an accumulation of glucocerebrosidase, a type of glycolipid, within the lysosomes. This can result in various symptoms, including enlargement of the liver and spleen, anemia, and bone pain.
Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.
Integrin α5β1, also known as very late antigen-5 (VLA-5) or fibronectin receptor, is a heterodimeric transmembrane receptor protein composed of two subunits: α5 and β1. This integrin is widely expressed in various cell types, including endothelial cells, smooth muscle cells, and fibroblasts.
Integrin α5β1 plays a crucial role in mediating cell-matrix adhesion by binding to the arginine-glycine-aspartic acid (RGD) sequence present in the extracellular matrix protein fibronectin. The interaction between integrin α5β1 and fibronectin is essential for various biological processes, such as cell migration, proliferation, differentiation, and survival. Additionally, this integrin has been implicated in several pathological conditions, including tumor progression, angiogenesis, and fibrosis.
'Clostridium' is a genus of gram-positive, rod-shaped bacteria that are widely distributed in nature, including in soil, water, and the gastrointestinal tracts of animals and humans. Many species of Clostridium are anaerobic, meaning they can grow and reproduce in environments with little or no oxygen. Some species of Clostridium are capable of producing toxins that can cause serious and sometimes life-threatening illnesses in humans and animals.
Some notable species of Clostridium include:
* Clostridium tetani, which causes tetanus (also known as lockjaw)
* Clostridium botulinum, which produces botulinum toxin, the most potent neurotoxin known and the cause of botulism
* Clostridium difficile, which can cause severe diarrhea and colitis, particularly in people who have recently taken antibiotics
* Clostridium perfringens, which can cause food poisoning and gas gangrene.
It is important to note that not all species of Clostridium are harmful, and some are even beneficial, such as those used in the production of certain fermented foods like sauerkraut and natto. However, due to their ability to produce toxins and cause illness, it is important to handle and dispose of materials contaminated with Clostridium species carefully, especially in healthcare settings.
Integrin beta4, also known as ITGB4 or CD104, is a type of integrin subunit that forms part of the integrin receptor along with an alpha subunit. Integrins are transmembrane proteins involved in cell-cell and cell-extracellular matrix (ECM) adhesion, signal transduction, and regulation of various cellular processes such as proliferation, differentiation, and migration.
Integrin beta4 is unique among the integrin subunits because it has a large cytoplasmic domain that can interact with several intracellular signaling molecules, making it an important regulator of cell behavior. Integrin beta4 is widely expressed in various tissues, including epithelial cells, endothelial cells, and hematopoietic cells.
Integrin beta4 forms heterodimers with integrin alpha6 to form the receptor for laminins, which are major components of the basement membrane. This receptor is involved in maintaining the integrity of epithelial tissues and regulating cell migration during development, tissue repair, and cancer progression. Mutations in ITGB4 have been associated with several human diseases, including epidermolysis bullosa, a group of inherited skin disorders characterized by fragile skin and blistering.
Excipients are inactive substances that serve as vehicles or mediums for the active ingredients in medications. They make up the bulk of a pharmaceutical formulation and help to stabilize, preserve, and enhance the delivery of the active drug compound. Common examples of excipients include binders, fillers, coatings, disintegrants, flavors, sweeteners, and colors. While excipients are generally considered safe and inert, they can sometimes cause allergic reactions or other adverse effects in certain individuals.
Cellulosomes are large, complex enzymatic structures produced by certain anaerobic bacteria that allow them to break down and consume cellulose, a major component of plant biomass. These structures are composed of multiple enzymes that work together in a coordinated manner to degrade cellulose into simpler sugars, which the bacteria can then use as a source of energy and carbon.
The individual enzymes in a cellulosome are non-covalently associated with a central scaffoldin protein, forming a multi-enzyme complex. The scaffoldin protein contains cohesin modules that bind to dockerin modules on the enzyme subunits, creating a highly organized and stable structure.
Cellulosomes have been identified in several species of anaerobic bacteria, including members of the genera Clostridium and Ruminococcus. They are thought to play a key role in the global carbon cycle by breaking down plant material and releasing carbon dioxide back into the atmosphere.
Glucans are polysaccharides (complex carbohydrates) that are made up of long chains of glucose molecules. They can be found in the cell walls of certain plants, fungi, and bacteria. In medicine, beta-glucans derived from yeast or mushrooms have been studied for their potential immune-enhancing effects. However, more research is needed to fully understand their role and effectiveness in human health.
Integrin α6β4 is a type of cell surface receptor that is composed of two subunits, α6 and β4. It is also known as CD49f/CD104. This integrin is primarily expressed in epithelial cells and plays important roles in cell adhesion, migration, and signal transduction.
Integrin α6β4 specifically binds to laminin-332 (also known as laminin-5), a component of the basement membrane, and forms a stable anchorage complex that links the cytoskeleton to the extracellular matrix. This interaction is critical for maintaining the integrity of epithelial tissues and regulating cell behavior during processes such as wound healing and tissue regeneration.
Mutations in the genes encoding integrin α6β4 have been associated with various human diseases, including epidermolysis bullosa, a group of inherited skin disorders characterized by fragile skin and blistering. Additionally, integrin α6β4 has been implicated in cancer progression and metastasis, as its expression is often upregulated in tumor cells and contributes to their invasive behavior.
Integrin beta chains are a type of subunit that make up integrin receptors, which are heterodimeric transmembrane proteins involved in cell-cell and cell-extracellular matrix (ECM) adhesion. These receptors play crucial roles in various biological processes such as cell signaling, migration, proliferation, and differentiation.
Integrin beta chains combine with integrin alpha chains to form functional heterodimeric receptors. In humans, there are 18 different alpha subunits and 8 different beta subunits that can combine to form at least 24 distinct integrin receptors. The beta chain contributes to the cytoplasmic domain of the integrin receptor, which is involved in intracellular signaling and cytoskeletal interactions.
The beta chains are characterized by a conserved cytoplasmic region called the beta-tail domain, which interacts with various adaptor proteins to mediate downstream signaling events. Additionally, some integrin beta chains have a large inserted (I) domain in their extracellular regions that is responsible for ligand binding specificity.
Examples of integrin beta chains include β1, β2, β3, β4, β5, β6, β7, and β8, each with distinct functions and roles in various tissues and cell types. Mutations or dysregulation of integrin beta chains have been implicated in several human diseases, including cancer, inflammation, fibrosis, and developmental disorders.
Beta 2-glycoprotein I, also known as apolipoprotein H, is a plasma protein that belongs to the family of proteins called immunoglobulin-binding proteins. It has a molecular weight of approximately 44 kDa and is composed of five domains with similar structures.
Beta 2-glycoprotein I is primarily produced in the liver and circulates in the bloodstream, where it plays a role in several physiological processes, including coagulation, complement activation, and lipid metabolism. It has been identified as an autoantigen in certain autoimmune disorders, such as antiphospholipid syndrome (APS), where autoantibodies against beta 2-glycoprotein I can cause blood clots, miscarriages, and other complications.
In medical terminology, the definition of "beta 2-glycoprotein I" is as follows:
A plasma protein that belongs to the family of immunoglobulin-binding proteins and has a molecular weight of approximately 44 kDa. It is primarily produced in the liver and circulates in the bloodstream, where it plays a role in several physiological processes, including coagulation, complement activation, and lipid metabolism. Autoantibodies against beta 2-glycoprotein I are associated with certain autoimmune disorders, such as antiphospholipid syndrome (APS), where they can cause blood clots, miscarriages, and other complications.
A base sequence in the context of molecular biology refers to the specific order of nucleotides in a DNA or RNA molecule. In DNA, these nucleotides are adenine (A), guanine (G), cytosine (C), and thymine (T). In RNA, uracil (U) takes the place of thymine. The base sequence contains genetic information that is transcribed into RNA and ultimately translated into proteins. It is the exact order of these bases that determines the genetic code and thus the function of the DNA or RNA molecule.
Integrin α4β1, also known as Very Late Antigen-4 (VLA-4), is a heterodimeric transmembrane receptor protein composed of two subunits, α4 and β1. It is involved in various cellular activities such as adhesion, migration, and signaling. This integrin plays a crucial role in the immune system by mediating the interaction between leukocytes (white blood cells) and the endothelial cells that line blood vessels. The activation of Integrin α4β1 allows leukocytes to roll along and then firmly adhere to the endothelium, followed by their migration into surrounding tissues, particularly during inflammation and immune responses. Additionally, Integrin α4β1 also interacts with extracellular matrix proteins such as fibronectin and helps regulate cell survival, proliferation, and differentiation in various cell types.
Hydrolysis is a chemical process, not a medical one. However, it is relevant to medicine and biology.
Hydrolysis is the breakdown of a chemical compound due to its reaction with water, often resulting in the formation of two or more simpler compounds. In the context of physiology and medicine, hydrolysis is a crucial process in various biological reactions, such as the digestion of food molecules like proteins, carbohydrates, and fats. Enzymes called hydrolases catalyze these hydrolysis reactions to speed up the breakdown process in the body.
Polysaccharides are complex carbohydrates consisting of long chains of monosaccharide units (simple sugars) bonded together by glycosidic linkages. They can be classified based on the type of monosaccharides and the nature of the bonds that connect them.
Polysaccharides have various functions in living organisms. For example, starch and glycogen serve as energy storage molecules in plants and animals, respectively. Cellulose provides structural support in plants, while chitin is a key component of fungal cell walls and arthropod exoskeletons.
Some polysaccharides also have important roles in the human body, such as being part of the extracellular matrix (e.g., hyaluronic acid) or acting as blood group antigens (e.g., ABO blood group substances).
Dextrins are a group of carbohydrates that are produced by the hydrolysis of starches. They are made up of shorter chains of glucose molecules than the original starch, and their molecular weight and physical properties can vary depending on the degree of hydrolysis. Dextrins are often used in food products as thickeners, stabilizers, and texturizers, and they also have applications in industry as adhesives and binders. In a medical context, dextrins may be used as a source of calories for patients who have difficulty digesting other types of carbohydrates.
Integrin α2β1, also known as very late antigen-2 (VLA-2) or laminin receptor, is a heterodimeric transmembrane receptor protein composed of α2 and β1 subunits. It belongs to the integrin family of adhesion molecules that play crucial roles in cell-cell and cell-extracellular matrix (ECM) interactions.
Integrin α2β1 is widely expressed on various cell types, including fibroblasts, endothelial cells, smooth muscle cells, and some hematopoietic cells. It functions as a receptor for several ECM proteins, such as collagens (type I, II, III, and V), laminin, and fibronectin. The binding of integrin α2β1 to these ECM components mediates cell adhesion, migration, proliferation, differentiation, and survival, thereby regulating various physiological and pathological processes, such as tissue repair, angiogenesis, inflammation, and tumor progression.
In addition, integrin α2β1 has been implicated in several diseases, including fibrosis, atherosclerosis, and cancer. Therefore, targeting this integrin with therapeutic strategies may provide potential benefits for treating these conditions.
Adrenergic receptors are a type of G protein-coupled receptor that bind and respond to catecholamines, such as epinephrine (adrenaline) and norepinephrine (noradrenaline). Beta-2 adrenergic receptors (β2-ARs) are a subtype of adrenergic receptors that are widely distributed throughout the body, particularly in the lungs, heart, blood vessels, gastrointestinal tract, and skeletal muscle.
When β2-ARs are activated by catecholamines, they trigger a range of physiological responses, including relaxation of smooth muscle, increased heart rate and contractility, bronchodilation, and inhibition of insulin secretion. These effects are mediated through the activation of intracellular signaling pathways involving G proteins and second messengers such as cyclic AMP (cAMP).
β2-ARs have been a major focus of drug development for various medical conditions, including asthma, chronic obstructive pulmonary disease (COPD), heart failure, hypertension, and anxiety disorders. Agonists of β2-ARs, such as albuterol and salmeterol, are commonly used to treat asthma and COPD by relaxing bronchial smooth muscle and reducing airway obstruction. Antagonists of β2-ARs, such as propranolol, are used to treat hypertension, angina, and heart failure by blocking the effects of catecholamines on the heart and blood vessels.
In the context of medicine and pharmacology, "kinetics" refers to the study of how a drug moves throughout the body, including its absorption, distribution, metabolism, and excretion (often abbreviated as ADME). This field is called "pharmacokinetics."
1. Absorption: This is the process of a drug moving from its site of administration into the bloodstream. Factors such as the route of administration (e.g., oral, intravenous, etc.), formulation, and individual physiological differences can affect absorption.
2. Distribution: Once a drug is in the bloodstream, it gets distributed throughout the body to various tissues and organs. This process is influenced by factors like blood flow, protein binding, and lipid solubility of the drug.
3. Metabolism: Drugs are often chemically modified in the body, typically in the liver, through processes known as metabolism. These changes can lead to the formation of active or inactive metabolites, which may then be further distributed, excreted, or undergo additional metabolic transformations.
4. Excretion: This is the process by which drugs and their metabolites are eliminated from the body, primarily through the kidneys (urine) and the liver (bile).
Understanding the kinetics of a drug is crucial for determining its optimal dosing regimen, potential interactions with other medications or foods, and any necessary adjustments for special populations like pediatric or geriatric patients, or those with impaired renal or hepatic function.
'Clostridium cellulolyticum' is a species of gram-positive, rod-shaped, anaerobic bacteria found in soil and aquatic environments. It is known for its ability to break down complex carbohydrates such as cellulose and hemicellulose into simple sugars through the process of fermentation. This makes it a potential candidate for biofuel production from plant biomass.
The bacterium produces a range of enzymes that can degrade these polysaccharides, including cellulases and xylanases. These enzymes work together in a complex system to break down the cellulose and hemicellulose into monosaccharides, which can then be fermented by the bacterium to produce various end products such as acetate, ethanol, hydrogen, and carbon dioxide.
'Clostridium cellulolyticum' is also known to produce a number of other enzymes and metabolites that have potential applications in industry, including amylases, proteases, and lipases. However, further research is needed to fully understand the biology and potential uses of this organism.
Messenger RNA (mRNA) is a type of RNA (ribonucleic acid) that carries genetic information copied from DNA in the form of a series of three-base code "words," each of which specifies a particular amino acid. This information is used by the cell's machinery to construct proteins, a process known as translation. After being transcribed from DNA, mRNA travels out of the nucleus to the ribosomes in the cytoplasm where protein synthesis occurs. Once the protein has been synthesized, the mRNA may be degraded and recycled. Post-transcriptional modifications can also occur to mRNA, such as alternative splicing and addition of a 5' cap and a poly(A) tail, which can affect its stability, localization, and translation efficiency.
Fermentation is a metabolic process in which an organism converts carbohydrates into alcohol or organic acids using enzymes. In the absence of oxygen, certain bacteria, yeasts, and fungi convert sugars into carbon dioxide, hydrogen, and various end products, such as alcohol, lactic acid, or acetic acid. This process is commonly used in food production, such as in making bread, wine, and beer, as well as in industrial applications for the production of biofuels and chemicals.
'Clostridium cellulovorans' is a species of gram-positive, rod-shaped, anaerobic bacteria that is commonly found in soil and aquatic environments. It is known for its ability to break down complex carbohydrates, such as cellulose and xylan, into simpler sugars, which it then ferments to produce various end products, including acetate, ethanol, hydrogen, and carbon dioxide.
The bacterium is of interest in the field of bioenergy, as its ability to efficiently convert plant biomass into useful chemicals has potential applications in the production of biofuels and other bioproducts. Additionally, 'C. cellulovorans' has been studied for its potential use in bioremediation, as it is capable of degrading a variety of pollutants, including polycyclic aromatic hydrocarbons (PAHs) and pesticides.
It is important to note that while 'C. cellulovorans' is generally considered to be a non-pathogenic bacterium, it can cause infections in individuals with compromised immune systems or underlying medical conditions. As with any potential pathogen, appropriate precautions should be taken when handling this organism in the laboratory setting.
In the context of medical terminology, tablets refer to pharmaceutical dosage forms that contain various active ingredients. They are often manufactured in a solid, compressed form and can be administered orally. Tablets may come in different shapes, sizes, colors, and flavors, depending on their intended use and the manufacturer's specifications.
Some tablets are designed to disintegrate or dissolve quickly in the mouth, making them easier to swallow, while others are formulated to release their active ingredients slowly over time, allowing for extended drug delivery. These types of tablets are known as sustained-release or controlled-release tablets.
Tablets may contain a single active ingredient or a combination of several ingredients, depending on the intended therapeutic effect. They are typically manufactured using a variety of excipients, such as binders, fillers, and disintegrants, which help to hold the tablet together and ensure that it breaks down properly when ingested.
Overall, tablets are a convenient and widely used dosage form for administering medications, offering patients an easy-to-use and often palatable option for receiving their prescribed treatments.
Integrins are a type of cell-adhesion molecule that play a crucial role in cell-cell and cell-extracellular matrix (ECM) interactions. They are heterodimeric transmembrane receptors composed of non-covalently associated α and β subunits, which form more than 24 distinct integrin heterodimers in humans.
Integrins bind to specific ligands, such as ECM proteins (e.g., collagen, fibronectin, laminin), cell surface molecules, and soluble factors, through their extracellular domains. The intracellular domains of integrins interact with the cytoskeleton and various signaling proteins, allowing them to transduce signals from the ECM into the cell (outside-in signaling) and vice versa (inside-out signaling).
These molecular interactions are essential for numerous biological processes, including cell adhesion, migration, proliferation, differentiation, survival, and angiogenesis. Dysregulation of integrin function has been implicated in various pathological conditions, such as cancer, fibrosis, inflammation, and autoimmune diseases.
Peptococcaceae is a family of obligately anaerobic, non-spore forming, gram-positive cocci that are found as normal flora in the human gastrointestinal tract. These bacteria are commonly isolated from feces and are known to be associated with various human infections, particularly intra-abdominal abscesses, bacteremia, and brain abscesses. The genus Peptococcus includes several species, such as Peptococcus niger and Peptococcus saccharolyticus, which are known to be associated with human infections. However, it is important to note that the taxonomy of this group of bacteria has undergone significant revisions in recent years, and some species previously classified as Peptococcaceae have been reassigned to other families.
"Cells, cultured" is a medical term that refers to cells that have been removed from an organism and grown in controlled laboratory conditions outside of the body. This process is called cell culture and it allows scientists to study cells in a more controlled and accessible environment than they would have inside the body. Cultured cells can be derived from a variety of sources, including tissues, organs, or fluids from humans, animals, or cell lines that have been previously established in the laboratory.
Cell culture involves several steps, including isolation of the cells from the tissue, purification and characterization of the cells, and maintenance of the cells in appropriate growth conditions. The cells are typically grown in specialized media that contain nutrients, growth factors, and other components necessary for their survival and proliferation. Cultured cells can be used for a variety of purposes, including basic research, drug development and testing, and production of biological products such as vaccines and gene therapies.
It is important to note that cultured cells may behave differently than they do in the body, and results obtained from cell culture studies may not always translate directly to human physiology or disease. Therefore, it is essential to validate findings from cell culture experiments using additional models and ultimately in clinical trials involving human subjects.
Interleukin-1 (IL-1) is a type of cytokine, which are proteins that play a crucial role in cell signaling. Specifically, IL-1 is a pro-inflammatory cytokine that is involved in the regulation of immune and inflammatory responses in the body. It is produced by various cells, including monocytes, macrophages, and dendritic cells, in response to infection or injury.
IL-1 exists in two forms, IL-1α and IL-1β, which have similar biological activities but are encoded by different genes. Both forms of IL-1 bind to the same receptor, IL-1R, and activate intracellular signaling pathways that lead to the production of other cytokines, chemokines, and inflammatory mediators.
IL-1 has a wide range of biological effects, including fever induction, activation of immune cells, regulation of hematopoiesis (the formation of blood cells), and modulation of bone metabolism. Dysregulation of IL-1 production or activity has been implicated in various inflammatory diseases, such as rheumatoid arthritis, gout, and inflammatory bowel disease. Therefore, IL-1 is an important target for the development of therapies aimed at modulating the immune response and reducing inflammation.
CD29, also known as integrin β1, is a type of cell surface protein called an integrin that forms heterodimers with various α subunits to form different integrin receptors. These integrin receptors play important roles in various biological processes such as cell adhesion, migration, and signaling.
CD29/integrin β1 is widely expressed on many types of cells including leukocytes, endothelial cells, epithelial cells, and fibroblasts. It can bind to several extracellular matrix proteins such as collagen, laminin, and fibronectin, and mediate cell-matrix interactions. CD29/integrin β1 also participates in intracellular signaling pathways that regulate cell survival, proliferation, differentiation, and migration.
CD29/integrin β1 can function as an antigen, which is a molecule capable of inducing an immune response. Antibodies against CD29/integrin β1 have been found in some autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus (SLE). These antibodies can contribute to the pathogenesis of these diseases by activating complement, inducing inflammation, and damaging tissues.
Therefore, CD29/integrin β1 is an important molecule in both physiological and pathological processes, and its functions as an antigen have been implicated in some autoimmune disorders.
Integrin α6β1, also known as CD49f/CD29, is a heterodimeric transmembrane receptor protein composed of α6 and β1 subunits. It is widely expressed in various tissues, including epithelial cells, endothelial cells, fibroblasts, and hematopoietic cells. Integrin α6β1 plays a crucial role in cell-matrix adhesion, particularly to the laminin component of the extracellular matrix (ECM). This receptor is involved in various biological processes such as cell migration, proliferation, differentiation, and survival. Additionally, integrin α6β1 has been implicated in tumor progression, metastasis, and drug resistance in certain cancers.
Psyllium is a type of fiber derived from the seeds of the Plantago ovata plant. It's often used as a bulk-forming laxative to help promote regularity and relieve constipation. When psyllium comes into contact with water, it swells and forms a gel-like substance that helps move waste through the digestive tract. In addition to its laxative effects, psyllium has also been shown to help lower cholesterol levels and control blood sugar levels in people with diabetes. It's available in various forms such as powder, capsules, and wafers, and can be found in many over-the-counter supplements and medications.
Molecular cloning is a laboratory technique used to create multiple copies of a specific DNA sequence. This process involves several steps:
1. Isolation: The first step in molecular cloning is to isolate the DNA sequence of interest from the rest of the genomic DNA. This can be done using various methods such as PCR (polymerase chain reaction), restriction enzymes, or hybridization.
2. Vector construction: Once the DNA sequence of interest has been isolated, it must be inserted into a vector, which is a small circular DNA molecule that can replicate independently in a host cell. Common vectors used in molecular cloning include plasmids and phages.
3. Transformation: The constructed vector is then introduced into a host cell, usually a bacterial or yeast cell, through a process called transformation. This can be done using various methods such as electroporation or chemical transformation.
4. Selection: After transformation, the host cells are grown in selective media that allow only those cells containing the vector to grow. This ensures that the DNA sequence of interest has been successfully cloned into the vector.
5. Amplification: Once the host cells have been selected, they can be grown in large quantities to amplify the number of copies of the cloned DNA sequence.
Molecular cloning is a powerful tool in molecular biology and has numerous applications, including the production of recombinant proteins, gene therapy, functional analysis of genes, and genetic engineering.
A cell line is a culture of cells that are grown in a laboratory for use in research. These cells are usually taken from a single cell or group of cells, and they are able to divide and grow continuously in the lab. Cell lines can come from many different sources, including animals, plants, and humans. They are often used in scientific research to study cellular processes, disease mechanisms, and to test new drugs or treatments. Some common types of human cell lines include HeLa cells (which come from a cancer patient named Henrietta Lacks), HEK293 cells (which come from embryonic kidney cells), and HUVEC cells (which come from umbilical vein endothelial cells). It is important to note that cell lines are not the same as primary cells, which are cells that are taken directly from a living organism and have not been grown in the lab.
Cellulose 1,4-β-cellobiosidase (reducing end)
Avicelase
Cellobiohydrolase
Cellulose 1,4-β-cellobiosidase (non-reducing end)
Non-homologous isofunctional enzymes
Cellulase
CELSS
Β-Glucosidase
Cels
List of MeSH codes (D08)
Cellulose 1,4-β-cellobiosidase (reducing end) - Wikipedia
SCOPe 2.08: Family a.102.1.2: Cellulases catalytic domain
Metagenomic discovery of biomass-degrading genes and genomes from cow rumen - PubMed
Sequence search - BRENDA Enzyme Database
Enzyme recovery in high-solids enzymatic hydrolysis of steam-pretreated willow: Requirements for the enzyme composition -...
1H-NMR stereospecific assignments by conformational data-base searches - PubMed
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PMID- 9339686
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Cellobiose1
- Lower microbial diversity, different taxonomic composition and functional profiles, and a greater abundance of genes involved in nitrogen fixation (nifB), cellulose degradation (beta-glucosidase), and cellobiose transport (cellulose 1, 4-beta-cellobiosidase) were found in the bamboo root endosphere than in the other rhizocompartments. (bvsalud.org)
Hydrolysis6
- Cellulases are a group of enzymes, which catalyse different steps of cellulose hydrolysis, and are broadly used in industry as unpurified mixtures of several enzymes. (springeropen.com)
- The total activity of cellulase is defined as the ability of the enzyme to produce glucose, which is the final product of cellulose hydrolysis, and is expressed in cellulase units. (springeropen.com)
- However, common strategies for the determination of the cellulolytic activity of industrial cellulase preparations are based on the assessment of different steps of cellulose hydrolysis, and the results obtained with different methods are not similar. (springeropen.com)
- The aim of the present study was to develop an assay for the determination of cellulase activity that relies on the amperometric determination of the final product of cellulose hydrolysis glucose. (springeropen.com)
- 2019 ). The enzyme mixture acts synergistically on the hydrolysis of cellulose which is gradually broken down from crystalline and/or amorphous cellulose to smaller, soluble fragments and finally to glucose (Dimarogona et al. (springeropen.com)
- During cellulose hydrolysis, endoglucanases first attack the amorphous area of the polysaccharide chain, breaking the β-1,4-glycosidic bonds releasing cellodextrin and creating new chain ends. (springeropen.com)
Cellobiohydrolase1
- Cellulose 1,4-β-cellobiosidase (reducing end) (EC 3.2.1.176, CelS, CelSS, endoglucanase SS, cellulase SS, cellobiohydrolase CelS, Cel48A) is an enzyme with systematic name 4-beta-D-glucan cellobiohydrolase (reducing end). (wikipedia.org)
Cellulase1
- The name "cellulase" is commonly used for a natural mixture of enzymes that in general includes three major glycosylases: endoglucanase (EC 3.2.1.4), exoglucanase (cellulase 1,4-beta-cellobiosidase (non-reducing end), EC 3.2.1.91), and cellobiase or β- d -glucosidase (EC 3.2.1.21) (Anoop Kumar et al. (springeropen.com)
Amino1
- Gene functional classification showed that most of enzyme-coding genes were related to cellulose digestion and amino acids metabolic pathways. (animbiosci.org)
Mechanism1
- 2006 ). The mechanism of cellulolytic action is illustrated in Fig. 1 . (springeropen.com)
ENZYME1
- All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1. (expasy.org)
Family1
- Some exocellulases, most of which belong to the glycoside hydrolase family 48 (GH48), act at the reducing ends of cellulose and similar substrates. (expasy.org)
Protein1
- Moreover, compounds + 1 and -1 could significantly suppress inflammation and inhibit the Akt signaling pathway by decreasing the phosphorylated protein levels of Akt. (bvsalud.org)
Found1
- The microbial flora in animals' gastrointestinal tract is a unique and diverse ecosystem, which has one of the highest cell density systems found so far [ 4 ]. (animbiosci.org)
Expression1
- Intriguingly, compound -1 treatment showed a much greater inhibition of TNF-α expression with an EC50 value of 1.80 µM, while compound + 1 had more advantages in reducing IL-1ß expression with an EC50 value of 19.93 µM. (bvsalud.org)
PMID3
- PMID- 9339686 OWN - NLM STAT- MEDLINE DA - 19971114 DCOM- 19971114 LR - 20061115 PUBM- Print IS - 0028-3878 (Print) VI - 49 IP - 4 DP - 1997 Oct TI - Higher neonatal cerebral blood flow correlates with worse childhood neurologic outcome. (nih.gov)
- PMID- 9357896 OWN - NLM STAT- MEDLINE DA - 19971120 DCOM- 19971120 LR - 20061115 PUBM- Print IS - 0003-3022 (Print) VI - 87 IP - 4 DP - 1997 Oct TI - Bupivacaine inhibition of L-type calcium current in ventricular cardiomyocytes of hamster. (nih.gov)
- PMID- 9298188 OWN - NLM STAT- MEDLINE DA - 19971117 DCOM- 19971117 LR - 20061115 PUBM- Print IS - 0003-6072 (Print) VI - 72 IP - 2 DP - 1997 Aug TI - Formation of formate and hydrogen, and flux of reducing equivalents and carbon in Ruminococcus flavefaciens FD-1. (nih.gov)
Data2
- the second is a systematic data base derived from conformations of a short peptide fragment with idealized geometry by systematically varying the phi, psi, and chi 1 torsion angles. (nih.gov)
- Both approaches are tested for beta-methylene groups with model data obtained from 20 crystal structures. (nih.gov)