Cellular Apoptosis Susceptibility Protein
National Institute of Environmental Health Sciences (U.S.)
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic and applied research to reduce the burden of human illness and dysfunction from environmental causes by, defining how environmental exposures, genetic susceptibility, and age interact to affect an individual's health. It was established in 1969.
DNA-Directed DNA Polymerase
DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
DNA Mismatch Repair
A DNA repair pathway involved in correction of errors introduced during DNA replication when an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. Excinucleases recognize the BASE PAIR MISMATCH and cause a segment of polynucleotide chain to be excised from the daughter strand, thereby removing the mismatched base. (from Oxford Dictionary of Biochemistry and Molecular Biology, 2001)
National Institutes of Health (U.S.)
Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. (1/50)Importin alpha plays a pivotal role in the classical nuclear protein import pathway. Importin alpha shuttles between nucleus and cytoplasm, binds nuclear localization signal-bearing proteins, and functions as an adapter to access the importin beta-dependent import pathway. In contrast to what is found for importin beta, several isoforms of importin alpha, which can be grouped into three subfamilies, exist in higher eucaryotes. We describe here a novel member of the human family, importin alpha7. To analyze specific functions of the distinct importin alpha proteins, we recombinantly expressed and purified five human importin alpha's along with importin alpha from Xenopus and Saccharomyces cerevisiae. Binding affinity studies showed that all importin alpha proteins from humans or Xenopus bind their import receptor (importin beta) and their export receptor (CAS) with only marginal differences. Using an in vitro import assay based on permeabilized HeLa cells, we compared the import substrate specificities of the various importin alpha proteins. When the substrates were tested singly, only the import of RCC1 showed a strong preference for one family member, importin alpha3, whereas most of the other substrates were imported by all importin alpha proteins with similar efficiencies. However, strikingly different substrate preferences of the various importin alpha proteins were revealed when two substrates were offered simultaneously. (+info)
Recycling of importin alpha from the nucleus is suppressed by loss of RCC1 function in living mammalian cells. (2/50)We previously reported that the nuclear import of substrates containing SV40 T antigen nuclear localization signal (NLS) was suppressed in a temperature-sensitive RCC1 mutant cell line, tsBN2, at nonpermissive temperature. Moreover, it was shown that import into wild type BHK21 cell-derived nuclei gradually decreased in heterokaryons between the tsBN2 and BHK21 cells, although the BHK21 nuclei retained wild type RCC1 and should contain RanGTP (Tachibana et al., 1994). In this study, it was found that in the heterokaryons cultured at non-permissive temperature, endogenous importin alpha was not detected immunocytochemically in the cytoplasm or BHK21 nuclei but only in the tsBN2 nuclei, suggesting that importin alpha cannot be exported from the RCC1-depleted nuclei. In fact, importin alpha microinjected into the nucleus of tsBN2 cells at non-permissive temperature remained in the nucleus. These results strongly support the hypothesis that the recycling of importin alpha from the nucleus requires nuclear RanGTP. Moreover, it was found that cytoplasmic injection of importin alpha restored the import of SV40 T-NLS substrates in the BHK21 nuclei but not the tsBN2 nuclei in the heterokaryons. This indicates that the decrease of importin alpha from the cytoplasm in the heterokaryons leads to a suppression of the efficiency of nuclear import of the T-NLS substrate and provides support for the view that nuclear RanGTP is essential for the nuclear entry of the substrates. (+info)
Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export. (3/50)We present here a detailed analysis of a rat polypeptide termed Nup50 (formerly NPAP60) that was previously found to be associated with the nuclear pore complex (F. Fan et al., Genomics 40:444-453, 1997). We have found that Nup50 (and/or a related 70-kDa polypeptide) is present in numerous rat cells and tissues. By immunofluorescence microscopy, Nup50 was found to be highly concentrated at the nuclear envelope of rat liver nuclei, whereas in cultured NRK cells it also is abundant in intranuclear regions. On the basis of immunogold electron microscopy of both rat liver nuclear envelopes and NRK cells, we determined that Nup50 is specifically localized in the nucleoplasmic fibrils of the pore complex. Microinjection of anti-Nup50 antibodies into the nucleus of NRK cells resulted in strong inhibition of nuclear export of a protein containing a leucine-rich nuclear export sequence, whereas nuclear import of a protein containing a classical nuclear localization sequence was unaffected. Correspondingly, CRM1, the export receptor for leucine-rich export sequences, directly bound to a fragment of Nup50 in vitro, whereas several other import and export receptors did not significantly interact with this fragment. Taken together, our data indicate that Nup50 has a direct role in nuclear protein export and probably serves as a binding site on the nuclear side of the pore complex for export receptor-cargo complexes. (+info)
G(i)-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways. (4/50)Since blood platelets release sphingosine 1-phosphate (Sph-1-P) upon activation, it is important to examine the effects of this bioactive lipid on vascular endothelial cell functions from the viewpoint of platelet-endothelial cell interactions. In the present study, we examined Sph-1-P-stimulated signaling pathways related to human umbilical vein endothelial cell (HUVEC) motility, with a special emphasis on the cytoskeletal docking protein Crk-associated substrate (Cas). Sph-1-P stimulated tyrosine phosphorylation of Cas, which was inhibited by the G(i) inactivator pertussis toxin but not by the Rho inactivator C3 exoenzyme or the Rho kinase inhibitor Y-27632. Fyn constitutively associated with and phosphorylated Cas, suggesting that Cas tyrosine phosphorylation may be catalyzed by Fyn. Furthermore, upon HUVEC stimulation with Sph-1-P, Crk, through its SH2 domain, interacted with tyrosine-phosphorylated Cas, and the Cas-Crk complex translocated to the cell periphery (membrane ruffles), through mediation of G(i) (Fyn) but not Rho. In contrast, tyrosine phosphorylation of focal adhesion kinase, and formation of stress fibers and focal adhesion were mediated by Rho but not G(i) (Fyn). Finally, Sph-1-P-enhanced HUVEC motility, assessed by a phagokinetic assay using gold sol-coated plates and a Boyden's chamber assay, was markedly inhibited not only by pertussis toxin (or the Fyn kinase inhibitor PP2) but also by C3 exoenzyme (or Y-27632). In HUVECs stimulated with Sph-1-P, these data suggest the following: (i) cytoskeletal signalings may be separable into G(i)-mediated signaling pathways (involving Cas) and Rho-mediated ones (involving FAK), and (ii) coordinated signalings from both pathways are required for Sph-1-P-enhanced HUVEC motility. Since HUVECs reportedly express the Sph-1-P receptors EDG-1 (coupled with G(i)) and EDG-3 (coupled with G(13) and G(q)) and the EDG-3 antagonist suramin was found to block specifically Rho-mediated responses, it is likely that Cas-related responses following G(i) activation originate from EDG-1, whereas Rho-related responses originate from EDG-3. (+info)
Identification of residues in the N-terminal domain of the Yersinia tyrosine phosphatase that are critical for substrate recognition. (5/50)YopH is a 468-amino acid protein-tyrosine phosphatase that is produced by pathogenic Yersinia species. YopH is translocated into host mammalian cells via a type III protein secretion system. Translocation of YopH into human epithelial cells results in dephosphorylation of p130(Cas) and paxillin, disruption of focal adhesions, and inhibition of integrin-mediated bacterial phagocytosis. Previous studies have shown that the N-terminal 129 amino acids of YopH comprise a bifunctional domain. This domain binds to the SycH chaperone in Yersinia to orchestrate translocation and to tyrosine-phosphorylated target proteins in host cells to mediate substrate recognition. We used random mutagenesis in combination with the yeast two-hybrid system to identify residues in the YopH N-terminal domain that are involved in substrate-binding activity. Four single codon changes (Q11R, V31G, A33D, and N34D) were identified that interfered with binding of the YopH N-terminal domain to tyrosine-phosphorylated p130(Cas) but not to SycH. These mutations did not impair YopH translocation into HeLa cells infected with Yersinia pseudotuberculosis. Introduction of the V31G substitution into catalytically inactive (substrate-trapping) forms of YopH interfered with the ability of these proteins to bind to p130(Cas) and to localize to focal adhesions in HeLa cells. In addition, the V31G substitution reduced the ability of catalytically active YopH to dephosphorylate target proteins in HeLa cells. These data indicate that the substrate- and SycH-binding activities of the YopH N-terminal domain can be separated and that the former activity is important for recognition and dephosphorylation of substrates by YopH in vivo. (+info)
Cse1l is essential for early embryonic growth and development. (6/50)The CSE1L gene, the human homologue of the yeast chromosome segregation gene CSE1, is a nuclear transport factor that plays a role in proliferation as well as in apoptosis. CSE1 and CSE1L are essential genes in Saccharomyces cerevisiae and mammalian cells, as shown by conditional yeast mutants and mammalian cell culture experiments with antisense-mediated depletion of CSE1L. To analyze whether CSE1L is also essential in vivo and whether its absence can be compensated for by other genes or mechanisms, we have cloned the murine CSE1L gene (Cse1l) and analyzed its tissue- and development-specific expression: Cse1l was detected at embryonic day 7.0 (E7.0), E11.0, E15.0, and E17.0, and in adults, high expression was observed in proliferating tissues. Subsequently, we inactivated the Cse1l gene in embryonic stem cells to generate heterozygous and homozygous knockout mice. Mice heterozygous for Cse1l appear normal and are fertile. However, no homozygous pups were born after interbreeding of heterozygous mice. In 30 heterozygote interbreeding experiments, 50 Cse1l wild-type mice and 100 heterozygotes were born but no animal with both Cse1l alleles deleted was born. Embryo analyses showed that homozygous mutant embryos were already disorganized and degenerated by E5.5. This implicates with high significance (P < 0.0001, Pearson chi-square test) an embryonically lethal phenotype of homozygous murine CSE1 deficiency and suggests that Cse1l plays a critical role in early embryonic development. (+info)
Functions of the adapter protein Cas: signal convergence and the determination of cellular responses. (7/50)Since Cas was first identified as a highly phosphorylated 130 kilodalton protein that associated with the v-Src and v-Crk-oncoproteins, considerable effort has been made to determine its function. Its predicted role as a scaffolding molecule based on its domain structure has been largely confirmed. Through its ability to undergo rapid changes in phosphorylation, subcellular localization and association with heterologous proteins, Cas may spatially and temporally regulate the function of its binding partners. Numerous proteins have been identified that bind to Cas in vitro and/or in vivo, but in only a few cases is there an understanding of how Cas may function in these protein complexes. To date, Cas-Crk and Cas-Src complexes have been most frequently implicated in Cas function, particularly in regards to processes involving regulation of the actin cytoskeleton and proliferation. These and other Cas protein complexes contribute to the critical role of Cas in cell adhesion, migration, proliferation and survival of normal cycling cells. However, under conditions in which these processes are deregulated, Cas appears to play a role in oncogenic transformation and perhaps metastasis. Therefore, in its capacity as an adapter protein, Cas serves as a point of convergence for many distinct signaling inputs, ultimately contributing to the generation of specific cellular responses. (+info)
Characterization of the nuclear export signal of polypyrimidine tract-binding protein. (8/50)The polypyrimidine tract-binding protein (PTB) is a nuclear protein that regulates alternative splicing. In addition, it plays a role in the cytoplasm during infection by some viruses and functions as a positive effector of hepatitis B virus RNA export. Thus, it presumably contains a nuclear export signal (NES). Using a heterokaryon export assay in transfected cultured cells, we have shown that the N-terminal 25 amino acid residues of PTB function as an autonomous NES, with residues 11-16 being important for its activity. Unlike the heteronuclear ribonucleoprotein A1 NES, this NES is separable from the nuclear localization signal, which spans the entire N-terminal 60 residues of PTB. The PTB NES cannot be shown to bind to CAS or Crm1, cellular receptors known to export proteins from the nucleus, and it functions in the presence of leptomycin B, a specific inhibitor of Crm1-dependent export. PTB deleted of its NES, unlike wild type PTB, does not stimulate the export of hepatitis B virus RNA. Therefore, the PTB NES is a functionally important domain of this multifunctional protein that utilizes an unknown export receptor. (+info)
Cellular apoptosis susceptibility protein
"Cas Proteins". www.sinobiological.com. Retrieved 2019-12-04. Cellular+Apoptosis+Susceptibility+Protein at the US National ... The Cas family of proteins are a family of proteins that induce cellular apoptosis and cell proliferation. Apoptosis is a ... The cellular apoptosis susceptibility protein (CAS) is an exportin which in the nucleus is bound to RanGTP. ... ALong with this correlation, in the absence of the CAS protein in a cell, there is an inhibition of apoptosis Along with being ...
CAS (cellular apoptosis susceptibility protein) is part of the importin-β superfamily of karyopherins and is defined as a ... but the key proteins involved had not been elucidated up until that point. A 60 kDa cytosolic protein, essential for protein ... Many different cargo proteins can be transported into the nucleus by importin. Often, different proteins will require different ... breast cancer type 1 susceptibility protein), into the nucleus. The overexpression of importin-α has also been linked with poor ...
Then the cellular apoptosis susceptibility protein (CAS), an exportin which in the nucleus is bound to RanGTP, displaces ... The proteins that make up the nuclear pore complex are known as nucleoporins; each NPC contains at least 456 individual protein ... This remodelling seems to allow the protein complex cdc2/cyclinB to enter the nucleus as well as many other proteins, such as ... Each of the eight protein subunits surrounding the actual pore (the outer ring) projects a spoke-shaped protein over the pore ...
List of MeSH codes (D12.776.543)
... cellular apoptosis susceptibility protein MeSH D12.776.543.585.750.500 - karyopherins MeSH D12.776.543.585.750.500.100 - alpha ... gtp-binding protein alpha subunit, gi2 MeSH D12.776.543.325.100.300 - gtp-binding protein alpha subunits, gq-g11 MeSH D12.776. ... proto-oncogene proteins c-kit MeSH D12.776.543.750.060.186 - proto-oncogene proteins c-met MeSH D12.776.543.750.060.217 - proto ... q-snare proteins MeSH D12.776.543.512.249.500.500 - qa-snare proteins MeSH D12.776.543.512.249.500.500.700 - syntaxin 1 MeSH ...
List of MeSH codes (D12.776.157)
... cellular apoptosis susceptibility protein MeSH D12.776.157.530.750.500 - karyopherins MeSH D12.776.157.530.750.500.100 - alpha ... rap1 gtp-binding proteins MeSH D12.776.157.325.515.500 - ras proteins MeSH D12.776.157.325.515.500.300 - oncogene protein p21( ... smad1 protein MeSH D12.776.157.057.170.500.200 - smad2 protein MeSH D12.776.157.057.170.500.300 - smad3 protein MeSH D12.776. ... smad proteins, inhibitory MeSH D12.776.157.057.170.249.600 - smad6 protein MeSH D12.776.157.057.170.249.700 - smad7 protein ...
Deleting the GSNOR gene from both yeast and mice increased the cellular levels of GSNO and nitrosylated proteins, and the yeast ... cells showed increased susceptibility to nitrosative stress. Null mice show increased levels of S-nitrosated proteins, ... trans-nitrosylates the active site cysteine of caspase-3 thus inactivating caspase-3 and preventing induction of apoptosis. As ... Through this catabolic process, GSNOR regulates the cellular concentrations of GSNO and plays a central role in regulating the ...
"Arginylated calreticulin at plasma membrane increases susceptibility of cells to apoptosis". The Journal of Biological ... This way of modifying proteins post-translationally does not occur in any other amino acid addition to proteins, such as in ... Lamon KD, Kaji H (1980). "Arginyl-tRNA transferase activity as a marker of cellular aging in peripheral rat tissues". ... Kashina AS (2015). "Protein Arginylation: Over 50 Years of Discovery". Protein Arginylation. Methods in Molecular Biology. Vol ...
FA proteins have cellular roles in autophagy and ribosome biogenesis in addition to DNA repair. FANCC, FANCA, FANCF, FANCL, ... leads to premature cellular senescence and therefore inhibition of haemopoietic function. Senescence, together with apoptosis, ... D'Andrea AD (2010). "Susceptibility pathways in Fanconi's anemia and breast cancer". N. Engl. J. Med. 362 (20): 1909-19. doi: ... that is detected by the FANCM protein. Following assembly, the protein core complex activates FANCL protein which acts as an E3 ...
An enhanced susceptibility to pyocyanin is seen in cells with certain mutant proteins or complexes. Mutations in genes ... Additionally, neutrophil apoptosis, immunoglobulin release from B-lymphocytes, and interleukin release (e.g. IL-8 and CCL5) are ... Pyocyanin is able to target a wide range of cellular components and pathways. Pathways that are affected by pyocyanin include ... Secondly, phosphorylation of CFTR by Protein kinase A II should occur in order for the channel to be operational. PKA II is ...
Targeted therapies are designed to affect cellular proteins or processes that are utilised by the cancer cells. This allows a ... Cancer cells can also cause defects in the cellular pathways of apoptosis (programmed cell death). As most chemotherapy drugs ... The susceptibility of an individual to liver damage can be altered by other factors such as the cancer itself, viral hepatitis ... Microtubules are an important cellular structure composed of two proteins, α-tubulin and β-tubulin. They are hollow, rod-shaped ...
Mechanisms of control via regulation of extracellular matrix proteins, cellular surface markers, cellular adhesion molecules, ... Apoptosis, or induced cell suicide, usually serves as a mechanism to prevent excessive cellular growth. Gatekeeper genes ... A third group of genes in which mutations lead to a significant susceptibility to cancer is the class of landscaper genes. ... Some key caretaker proteins that contribute to cell survival by acting in DNA repair processes when the level of damage is ...
"Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration". Biochemical and ... it is suggested that susceptibility to FASTKD2-mediated apoptosis requires certain factors to associate with the DIF-1 complex ... FAST kinase domain-containing protein 2 (FASTKD2) is a protein that in humans is encoded by the FASTKD2 gene on chromosome 2. ... plasma membrane breakdown and cellular disintegration. Apoptosis occurs in many physiological and pathological processes. It ...
The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the ... "Localization of a susceptibility gene for common forms of stroke to 5q12". American Journal of Human Genetics. 70 (3): 593-603 ... Cellular Signalling. 13 (7): 507-13. doi:10.1016/S0898-6568(01)00167-X. PMID 11516626. Michot C, Le Goff C, Goldenberg A, ... "Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia". ...
Synthesis of viral proteins begins within hours of viral entry with necrosis or apoptosis occurring as early as a few hours ... Pearman, Peter B.; Garner, Trenton W. J. (2005). "Susceptibility of Italian agile frog populations to an emerging strain of ... This decrease in immune function and warmer environmental temperatures allows for greater viral replication and cellular damage ... The main structural component of the protein capsid is the major capsid protein (MCP). Ranaviral replication is well-studied ...
... susceptibility to leukemia and other cancers, and cellular hypersensitivity to interstrand DNA cross-linking agents. Generally ... Amongst known FANC proteins, most evidence points for a direct interaction primarily between FANCA protein and BRCA1. Evidence ... Also apoptosis is increased in the mutant germ cells. The Fanconi anemia DNA repair pathway appears to play a key role in ... This mechanic is also supported by the protein-protein interactions between BRG1 and both BRCA1 and FANCA, that serve to ...
Severe congenital neutropenia
Accelerated apoptosis occurs in the neutrophils and bone marrow. X-linked SCN (SCNX) is caused by mutation in the WASP gene on ... The GATA2 protein is a transcription factor critical for the embryonic development, maintenance, and functionality of blood- ... These autosomal dominant mutations cause a reduction, i.e. a haploinsufficiency, in the cellular levels of the gene's product, ... Over time, however, the deficiency commonly progresses to include thrombocytopenia, increases susceptibility to infections due ...
Inhibitor of apoptosis
The Inhibitors of apoptosis proteins (IAP) are a family of functionally and structurally related proteins that serve as ... Callus BA, Vaux DL (January 2007). "Caspase inhibitors: viral, cellular and chemical". Cell Death and Differentiation. 14 (1): ... reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shock". Oncogenesis. 5: e216. ... Inhibitors of apoptosis are a group of proteins that mainly act on the intrinsic pathway that block programmed cell death, ...
Activated FANCD2 protein co-localizes with BRCA1 (breast cancer susceptibility protein) at ionizing radiation-induced foci and ... The main cellular phenotype is hypersensitivity to DNA damage, particularly inter-strand DNA crosslinks. The FA proteins ... Loss of FANCG causes neural progenitor apoptosis during forebrain development, likely related to defective DNA repair. (Sii- ... Fanconi anemia group G protein is a protein that in humans is encoded by the FANCG gene. FANCG, involved in Fanconi anemia, ...
Phorbol-12-myristate-13-acetate-induced protein 1
"The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells". Immunity. 24 (6): 703- ... Sun Y, Leaman DW (2005). "Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus ... Apoptosis Apoptosome Bcl-2 Bcl-2-associated X protein (BAX) BH3 interacting domain death agonist (BID) Caspases Cytochrome c ... Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known ...
In addition, INK4 proteins play roles in cellular senescence, apoptosis and DNA repair. INK4 proteins are tumor suppressors and ... p15INK4b/p16INK4a homolog were found to segregate with melanoma susceptibility in the Xiphophorus indicating that INK4 proteins ... The other family of CKIs, CIP/KIP proteins are capable of inhibiting all CDKs. Enforced expression of INK4 proteins can lead to ... INK4 proteins are cell-cycle inhibitors. When they bind to CDK4 and CDK6, they induce an allosteric change that leads to the ...
Germinal center B-cell like diffuse large B-cell lymphoma
Apoptosis is one of the major mechanisms of cell death targeted by cancer therapies. Reduced susceptibility to apoptosis ... Bcl-2 proteins prevent the activation of the caspases that lead to programmed cell death (apoptosis).[self-published source?] ... BCL-6 is also an inhibitor of cellular senescence. Cellular senescence is a programmed response that prevents a cell from ... 14-3-3 proteins exert anti-apoptotic activity by interfering with the function of BH3-only proteins and has been validated as a ...
Indeed, TBX3 can bypass cellular senescence, apoptosis and anoikis as well as promote uncontrolled cell proliferation, tumor ... December 2011). "Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43". Cellular and Molecular Life ... Genome wide association studies also causally linked TBX3 to rheumatoid arthritis (RA) susceptibility and a recent study ... T-box transcription factor TBX3 is a protein that in humans is encoded by the TBX3 gene. T-box 3 (TBX3) is a member of the T- ...
... a protein known to rescue red blood cell progenitors from apoptosis. The D'Andrea laboratory at the Dana Farber Cancer ... anemia is an autosomal-recessive cancer susceptibility disorder characterized by developmental defects and increased cellular ... D'Andrea's research at the Dana Farber Cancer Institute focuses on chromosome instability and cancer susceptibility. He is ... D'Andrea, Alan D. (2010-05-20). "Susceptibility pathways in Fanconi's anemia and breast cancer". The New England Journal of ...
"Association analysis of cystatin A and zinc finger protein 148, two genes located at the psoriasis susceptibility locus PSORS5 ... a Krüppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter". Molecular and Cellular ... Bai L, Yoon SO, King PD, Merchant JL (Jun 2004). "ZBP-89-induced apoptosis is p53-independent and requires JNK". Cell Death and ... Zinc finger protein 148 is a protein that in humans is encoded by the ZNF148 gene. ZNF148 has been shown to interact with PTRF ...
Similar to p53 the protein product of p73 induces cell cycle arrest or apoptosis, hence its classification as a tumor ... Adenoviruses that cause cellular transformations have also been found to result in increased p73 expression. Furthermore, ... which do not exhibit an increased susceptibility to spontaneous tumorigenesis, have neurological and immunological defects. ... p73 is a protein related to the p53 tumor protein. Because of its structural resemblance to p53, it has also been considered a ...
... of the novel protein PHACTR-1 from human endothelial cells abolishes tube formation and induces cell death receptor apoptosis ... Fan X, Wang J, Fan W, Chen L, Gui B, Tan G, Zhou J (April 2014). "Replication of migraine GWAS susceptibility loci in Chinese ... Cellular Signalling. 24 (1): 214-23. doi:10.1016/j.cellsig.2011.09.003. PMID 21939755. Reschen ME, Lin D, Chalisey A, Soilleux ... PHACTR1 is an actin and protein phosphatase 1 (PP1) binding protein that binds actin and regulates the reorganization of the ...
... is a transmembrane protein of the G protein-coupled receptor 1 (GPCR1) family and the only known member of the CX3C chemokine ... CX3CR1 is also a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and ... All of those signalling cascades are responsible for diverse cellular behaviours and regulations, in terms of increased ... proliferation and apoptosis resistance, for facilitating metastasis). Therefore, it has a lot of potential as therapeutical ...
"Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1". Nat. Med. 7 (7): ... different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to ... and cellular transport". Exp. Cell Res. 289 (2): 211-21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622. Wang T, Arifoglu P, ... influence of polymorphism on cancer susceptibility". IARC Sci. Publ. (148): 231-49. PMID 10493261. Kellen E, Hemelt M, Broberg ...
RAP80, a subunit of the DNA repair breast cancer type 1 susceptibility protein complex (BRCA1-A), binds ubiquitin attached to ... BRCA1-A activity arrests the cell cycle at the G2/M checkpoint, allowing time for DNA repair, or apoptosis may be initiated. In ... A high level of H2A.Z expression is detected in many cancers and is significantly associated with cellular proliferation and ... HMGA2 protein specifically targets the promoter of ERCC1, thus reducing expression of this DNA repair gene. ERCC1 protein ...
This leads to degradation of cellular components for apoptosis. Extrinsic apoptopic pathway: The caspase cascade is also ... which is facilitated by binding to adaptor proteins via protein-protein interaction motifs that are collectively referred to as ... Insufficient activation of these caspases can increase an organism's susceptibility to infection, as an appropriate immune ... In animals apoptosis is induced by caspases and in fungi and plants, apoptosis is induced by arginine and lysine-specific ...
Germ cell nest
These intra-cellular bridges promote germ cell communication and sharing of cytoplasmic constituents, and allow for ... The germ cells that donate their cytoplasm undergo apoptosis. Besides this function, it has been proposed that germ-line cysts ... Developing sperm carrying a Y chromosome can be supplied with essential proteins encoded by genes on the X chromosome. de ... which reduces its susceptibility to mutations and parasites (largely applies to insect models). However, there doesn't seem to ...
Cyclin D-CDK4/6 complexes in turn mono-phosphorylates the retinoblastoma susceptibility protein (Rb) to pRb. The un- ... Cellular model Eukaryotic DNA replication Origin recognition complex Retinoblastoma protein Synchronous culture - ... Thus there is a net increase in cell number as the number of cells that die by apoptosis or senescence remains the same. The ... Cellular senescence occurs in response to DNA damage and external stress and usually constitutes an arrest in G1. Cellular ...
Secondly, another insert of 20 amino acids in the 10th spectrin repeat, termed SH3i+, contains protein kinase A and protein ... Molecular and Cellular Biology. 8 (1): 1-9. doi:10.1128/MCB.8.1.1. PMC 363070. PMID 3336352. McMahon AP, Giebelhaus DH, ... Alpha II-spectrin has shown promising utility as a biomarker for brain necrosis and apoptosis in infants with congenital heart ... "Site-directed mutagenesis of alpha II spectrin at codon 1175 modulates its mu-calpain susceptibility". Biochemistry. 36 (1): 57 ...
"Expression of X-linked inhibitor of apoptosis protein in human prostate cancer specimens with and without neo-adjuvant hormonal ... November 1996). "Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search". Science. ... One theory is that tumour cells undergo several genetic changes during transformation which alter the cellular rate of growth ... Transport protein ZIP1 is responsible for the transport of zinc into prostate cells. One of zinc's important roles is to change ...
DNA damage theory of aging
... whereby DNA crosslinks occur when both normal cellular repair processes fail and cellular apoptosis does not occur. ... At the cellular level, mutations can cause alterations in protein function and regulation. Mutations are replicated when the ... 2015). "Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1- ... Nuclear DNA damage can contribute to aging either indirectly (by increasing apoptosis or cellular senescence) or directly (by ...
... protein-L-isoaspartate (D-aspartate) O-methyltransferase (6q25.1) PERP: p53 apoptosis effector related to PMP-22 (6q23.3) PKIB ... dyslexia susceptibility 4 ECT2L: encoding protein Epithelial cell transforming sequence 2 oncogene-like ESR1: Estrogen receptor ... cellular)-related 6 SENP6: SUMO1/sentrin specific peptidase 6 (6q14.1) SERAC1: serine active site containing 1 (6q25.3) SERINC1 ... encoding protein Absent in melanoma 1 protein (6q21) AIG1: encoding protein Androgen-induced protein 1 (6q24.2) AKIRIN2: akirin ...
... including the Akt protein kinase and the cell death-associated protein IκB. Progesterone inhibits apoptosis in immortalized ... Crudden G, Chitti RE, Craven RJ (Jan 2006). "Hpr6 (heme-1 domain protein) regulates the susceptibility of cancer cells to ... Molecular and Cellular Biology. 25 (5): 1669-79. doi:10.1128/MCB.25.5.1669-1679.2005. PMC 549369. PMID 15713626. Thompson AM, ... is a protein which co-purifies with progesterone binding proteins in the liver and ovary. In humans, the PGRMC1 protein is ...
... half of the protein). The unregulated expression of this protein activates other proteins that are involved in cell cycle and ... Bishop and Varmus were awarded the Nobel Prize in Physiology or Medicine in 1989 for their discovery of the cellular origin of ... Most normal cells will undergo a programmed form of rapid cell death (apoptosis) when critical functions are altered and ... gene Oncogenomics Tumor suppressor gene Oncovirus Genetic predisposition Quantitative trait locus Genetic susceptibility ...
... which respectively encode the canalicular transport proteins BSEP and multidrug resistance protein 3 (MDR3). MDR3 is ... Crawford JM (1997). "Cellular and molecular biology of the inflamed liver". Current Opinion in Gastroenterology. 13 (3): 175- ... E.g., with Alagille syndrome limited degeneration occurs, however, there may be a small amount of apoptosis and enlarged ... Further evidence for genetic predisposition include the identification of 23 non-HLA susceptibility loci and a higher disease ...
Nelson AM, Gilliland KL, Cong Z, Thiboutot DM (October 2006). "13-cis Retinoic acid induces apoptosis and cell cycle arrest in ... The most common adverse effects are dry lips (cheilitis), dry and fragile skin, and an increased susceptibility to sunburn. ... Isotretinoin is primarily (99.9%) bound to plasma proteins, mostly albumin. Three metabolites of isotretinoin are detectable in ... "cellular immortalization and tumorigenesis." In a 2007 study, isotretinoin was proven to inhibit the action of the ...
Overexpression of p28 in cells causes cellular rounding and detachment, and induces apoptosis, probably because of a dominant- ... novel SH2-containing protein family), and other proteins such as the Id family of helix-loop-helix proteins. In terms of post- ... "Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease". ... Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) is a protein that in humans is encoded by the ...
Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene. EGR2 (also termed Krox20) is a ... Unoki M, Nakamura Y (April 2003). "EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and ... September 2015). "Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite". Nature ... Molecular and Cellular Biology. 9 (2): 787-97. doi:10.1128/mcb.9.2.787. PMC 362656. PMID 2496302. Joseph LJ, Le Beau MM, ...
Allosteric inhibition and activation by Protein-protein interactions (PPI). Indeed, some proteins interact with and regulate ... In the cellular environment, all three hydroxyl groups of ADP dissociate into −O− and H+, giving ADP3−, and this ion tends to ... July 2006). "TIGAR, a p53-inducible regulator of glycolysis and apoptosis". Cell. 126 (1): 107-120. doi:10.1016/j.cell.2006.05. ... Often these enzymes are Isoenzymes, of traditional glycolysis enzymes, that vary in their susceptibility to traditional ...
Cell cycle analysis
The concurrent measurement of cellular DNA and RNA content, or DNA susceptibility to denaturation at low pH using the ... during apoptosis, the DNA is degraded by cellular endonucleases. Therefore, nuclei of apoptotic cells contain less DNA than ... Darzynkiewicz Z, Gong JP, Juan G, Ardelt B, Traganos F (1996). "Cytometry of cyclin proteins". Cytometry. 25 (1): 1-13. doi: ... The cellular DNA content of individual cells is often plotted as their frequency histogram to provide information about ...
Paraskevas S, Huizinga JD, Loos BG (April 2008). "A systematic review and meta-analyses on C-reactive protein in relation to ... Both periodontal disease and cancer risk are associated with genetic susceptibility and it is possible that there is a positive ... Oxidative stress favours the development and progression of heart failure as it causes cellular dysfunction, oxidation of ... resulting in cell necrosis or apoptosis. Furthermore, individuals with uncontrolled diabetes mellitus who have frequent ...
3DG induces apoptosis in macrophage-derived cell lines and is toxic to cultured cortical neurons and PC12 cells. 3DG induces ... 3DG reacts with protein to form advanced glycation end-products (AGEs), which contribute to diseases such as the vascular ... Aldehyde reductase is the cellular enzyme that protects the body from 3DG. Detoxification of 3DG to 3-deoxyfructose (3DF) is ... Beisswenger PJ, Drummond KS, Nelson RG, Howell SK, Szwergold BS, Mauer M (November 2005). "Susceptibility to diabetic ...
Epigenetics of neurodegenerative diseases
Normal SOD protein is also implicated in other cases of ALS due to potentially cellular stress. An ALS mouse model through gain ... and counteract apoptosis initiation. Furthermore, HDAC inhibitors are known to prevent SOD1 protein aggregates in vitro. Sodium ... which is the link with which it is thought that smoking can induce epigenetic changes that increase susceptibility to MS. ... As that gene's name suggests, BACE1 is an enzymatic protein that cleaves the Amyloid Precursor Protein into the insoluble ...
The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed ... A. Cellular T Cell Response The first evidence of survivin-specific CTL recognition and killing was shown in an assay wherein ... targeting survivin and blocking it would enhance prostate cancer cell susceptibility to anti-androgen therapy. (Anti-androgen ... Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded ...
... induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose ... This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 ... lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular ... It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has ...
DNA-binding protein Ikaros also known as Ikaros family zinc finger protein 1 is a protein that in humans is encoded by the ... The two effects appear to be in opposite directions, with the allele marking susceptibility to ALL protecting from T1D and vice ... The deregulation then can result in low proliferation rate and increased apoptosis of the B cells. The deregulation may be ... Molecular and Cellular Biology. 14 (11): 7111-23. doi:10.1128/mcb.14.11.7111. PMC 359245. PMID 7935426. "Entrez Gene: IKZF1 ...
A T cell with a receptor that doesn't react, or reacts weakly will die by apoptosis. A T cell that does react will survive and ... Immunophenotyping will reveal cells that are CD3, a protein found on T cells, and help further distinguish the maturity of the ... but the neck of the flask persists for some time as a cellular cord. By further proliferation of the cells lining the flask, ... results in severe immunodeficiency and subsequent high susceptibility to infection by viruses, protozoa, and fungi. Nude mice ...
Using agents which mimic the virus-associated protein (VAP) and bind to the cellular receptors. This may include VAP anti- ... DRACO effects cell death via one of the last steps in the apoptosis pathway in which complexes containing intracellular ... Antiviral resistance can be defined by a decreased susceptibility to a drug caused by changes in viral genotypes. In cases of ... or parts of proteins, that can be disabled. These "targets" should generally be as unlike any proteins or parts of proteins in ...
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... Lung Cellular and Molecular Physiology. 306 (11): L1006-15. doi:10.1152/ajplung.00015.2014. PMC 4042193. PMID 24705725. ... Knock-out models of MMP9 result in delayed apoptosis, vascularization, and ossification of hypertrophic chondrocytes. Lastly, ... was protective against placental malaria which suggests a possible role of MMP-9 in susceptibility to malaria. Dry eye patients ...
While it is known that these domains are present in the protein, their role in protein function remains unclear. AGGF1 was the ... "AGGF1 protects from myocardial ischemia/reperfusion injury by regulating myocardial apoptosis and angiogenesis". Apoptosis. 19 ... Single nucleotide polymorphisms in intron 11 and exon 7 were associated with KTS susceptibility even though neither of these ... Cellular and Molecular Life Sciences. 62 (13): 1434-47. doi:10.1007/s00018-005-4523-7. PMC 1579804. PMID 15905966. Kihiczak GG ...
C-protein facilitates budding by interacting with AIP1/Alix, which is a host protein that is involved in apoptosis and ... Two of SeV proteins: HA and F, after their binding directly to a cellular membrane, promote a cell-cell fusion, which leads to ... Parker JC, Whiteman MD, Richter CB (January 1978). "Susceptibility of inbred and outbred mouse strains to Sendai virus and ... matrix protein (M), fusion protein (F), neuraminidase (NA) and large protein (L). All these proteins have variable functions ...
Cellular Apoptosis Susceptibility Protein - Preferred Concept UI. M0253556. Scope note. A nucleocytoplasmic transport protein ... Cellular Apoptosis Susceptibility Protein Entry term(s). CAPTS gene product CAS Export Factor CSE1L Protein Chromosome ... Cellular Apoptosis Susceptibility Protein Descriptor Spanish: Proteína de Susceptibilidad a Apoptosis Celular Spanish from ... CELLULAR APOPTOSIS SUSCEPTABILITY PROTEIN was indexed under PROTEINS 1995-2001. History Note:. 2002; use CELLULAR APOPTOSIS ...
Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma | Cancer Cell International |...
Cellular apoptosis susceptibility (CSE1L/CAS) protein in cancer metastasis and chemotherapeutic drug-induced apoptosis. J Exp ... CSE1L, also named as CAS (cellular apoptosis susceptibility protein), has been reported as an oncogene in several cancers [20, ... c The representative protein expression of the six genes in HCC and normal liver tissue. Data were from the Human Protein Atlas ... 3b). We further explored the protein expression of the six genes in the Human Protein Profiles and shown the characteristic ...
International Master/Ph.D. Program in Medicine - Research output - Taipei Medical University
Cellular Apoptosis Susceptibility Protein 100% * Microphthalmia-Associated Transcription Factor 74% * Cyclic AMP Response ... Lee, S. F., Huang, H. M., Chao, J. R., Lin, S., Yang-Yen, H. F. & Yen, J. J. Y., Nov 1999, In: Molecular and Cellular Biology. ... Cytotoxic T-lymphocyte antigen 4 polymorphisms and breast cancer susceptibility: Evidence from a meta-analysis. Chang, H. Y., ... Cytokine receptor common β chain as a potential activator of cytokine withdrawal-induced apoptosis. ...
Pesquisa | Prevenção e Controle de Câncer
We report here that the human cellular apoptosis susceptibility protein (hCAS/CSE1L) associates with a subset of p53 target ... The p53 tumor suppressor protein regulates many genes that can determine different cellular outcomes such as growth arrest or ... Deficiency in DNA repair proteins confers susceptibility to DNA damage, making cancer cells vulnerable to various cancer ... Heat-shock protein 90 (HSP90) is one of the chaperone molecules required for appropriate folding of proteins such as KIT. ...
Pseudotuberculosis (Yersinia pseudotuberculosis Infection): Practice Essentials, Background, Pathophysiology
... which promotes cellular attachment, the outer proteins (Yops), which inhibit host defense by inducing apoptosis, and a ... 12] explaining the susceptibility among individuals with hemochromatosis or hemophilia. Other factors include YadA, which is ... owing to outer-protein inhibition of phagocytosis.  The infection then spreads to the Peyer patches and draining mesenteric ... responsible, but apparently not necessary, for invasion, the surface protein MyfA, ...
Cullin Proteins | Profiles RNS
Cellular Apoptosis Susceptibility Protein. *Cullin Proteins. *Cyclin-Dependent Kinase Inhibitor Proteins. *Cyclin-Dependent ... "Cullin Proteins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Cullin Proteins" by people in this website by year, and ... A family of structurally related proteins that were originally discovered for their role in cell-cycle regulation in ...
NIOSHTIC-2 Search Results - Full View
Exposure to freshly fractured or aged silica produced divergent cellular responses in certain downstream cellular events, ... p53 protein was present in the BEAS-IIB and was absent in cancer cell lines after silica exposure. Exposure to freshly ... Apoptosis showed a comparable enhanced level of induction with freshly fractured or aged silica in both cancer lines with p53 ... and thereby enhances susceptibility and augments cell proliferation and lung cancer development. ...
CometAssay 96 ES Starter Kit plus Power Supply for UK
Cellular repair resolves the DNA damage and nucleoids containing specific DNA and the breaks are tested with the comet assay. ... For measuring DNA damage from apoptosis, cell death by cytotoxicity and strand breaks at incomplete excision repair sites or ... Endonucleases damage increases the DNA migration, whereas DNA-DNA and DNA-protein cross-links result in retarded DNA migration ... Performed on Drosophila melanogaster cells or for human DNA damage studies for cancer susceptibility by environmental factors, ...
Extracts and Essential Oils from Medicinal Plants and Their Neuroprotective Effect | IntechOpen
Misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4- and cytochrome c-related mechanisms. American Journal of ... activation has been shown to be a fundamental step in the apoptosis process and its inhibition may block cellular apoptosis. ... consequently decreasing the susceptibility to oxidation. In step B: essential oils from different medicinal plants demonstrated ... Curcumin acts by preventing the formation and aggregation of β-amyloid protein and hyperphosphorylation of tau protein, ...
Find Research outputs - Discovery - the University of Dundee Research Portal
Susceptibility of lens epithelial and fibre cells at different stages of differentiation to apoptosis. Dahm, R., Gribbon, C., ... Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. ... Molecular and Cellular Biology. 34, 17, p. 3305-3320 16 p.. Research output: Contribution to journal › Article › peer-review ... Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline. Kreutzfeld, O., Tumwebaze, P. K., ...
Frontiers | Microbial dysbiosis in the gut drives systemic autoimmune diseases
... affecting gene expression at the post-transcriptional level or production of microbial metabolites that interact with cellular ... affecting gene expression at the post-transcriptional level or production of microbial metabolites which interact with cellular ... modulates susceptibility to T1D through a variety of possible mechanisms such as upregulation of tight junction proteins (94). ... Lactobacilli stimulates cellular receptors involved in translocation of glucose, production of phosphatidyl inositol-3- ...
β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer |...
The interaction of mutp53 proteins with transcription regulators, and other cellular proteins can reshape the tumor cell ... Overall these findings reveal the role of YAP as an effector of ET-1R/β-arr1 pathway in inducing apoptosis protection and that ... metastasis and reduced platinum susceptibility in HG-SOC (Fig. 7f). In parallel, we establish ET-1 as an external cue that ... e, g pYAP (S127) and YAP protein expression of PMOV10 PDX ip nodules extracts (e) or pYAP, YAP, β-arr1, and p53 protein ...
Viruses | Free Full-Text | The Incorporation of Host Proteins into the External HIV-1 Envelope
While this mechanism might seemingly imply that host protein incorporation is a passive uptake of all cellular antigens ... We discuss how HIV-1 virions displaying host proteins on their surface can exhibit a myriad of altered phenotypes, with notable ... Given the broad range of biologically active host proteins acquired on the surface of HIV-1, additional studies on the ... Herein, we review the evidence indicating that host protein incorporation can be a selective and conserved process. ...
Dr. Peter D'Adamo / Cancer and ABO Blood Group
... then apoptosis is a final suicidal crash.. Most, if not all, of the many proteins encoded by cellular oncogenes are involved ... This oral disease susceptibility is reflected in the occurrence of epithelial dysplasia, for example, which is found almost ... Blood type B generally acts a bit more like blood type O, imparting a degree of reduced susceptibility or reduced risk. This is ... Possible linkage of a breast cancer-susceptibility locus to the ABO locus: sensitivity of LOD scores to a single new ...
Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy
Under oxidative stress conditions, excessive ROS can damage cellular proteins, lipids, and DNA, leading to cell damage that may ... and their products are components of cell signaling pathways and play important roles in cellular physiology and ... Apoptosis Signal-Regulating Kinase 1 (ASK1) and p38 MAPK. Apoptosis signal-regulating kinase 1 (ASK1) has been shown to act as ... While GSH loss, or a decrease in glutathione/glutathione disulphide ratio (GSH/GSSG), leads to an increased susceptibility to ...
Micronutrients and many important factors that affect the physiological functions of toll-like receptors | Bulletin of the...
Among these are inflammation, cytokines, some cellular process, air pollution, depression, stress, some drugs, genetic ... 2001), cellular processes such as cell migration and apoptosis (Herrera et al. 2011), air pollution (Zhang and Gallo 2016), ... Comparative microarray analysis of gene expression during apoptosis-induction by growth factor deprivation or protein kinase C ... 2016) and increased susceptibility to infection and diseases (Maggini et al. 2007). B12 deficiency increased the level of TNF-α ...
Making Cholesterol-Lowering Statin Drugs More Effective Against Cancer - Cancer Treatments - from Research to Application
... and initiates cellular apoptosis. This unique tumor cell-specific sensitivity allows isoprenoids to be used for tumor therapy, ... resulting in up-regulation of proapoptotic protein p53 up-regulated modulator of apoptosis (PUMA). In support of these findings ... The elevated reductase expression and greater demand for nonsterol products to maintain growth amplify the susceptibility of ... initiate apoptosis, and suppress cellular signaling activities. Perillyl alcohol, the isoprenoid of greatest clinical interest ...
Novel Human Reovirus Isolated from Children with Acute Necrotizing Encephalopathy - Volume 17, Number 8-August 2011 - Emerging...
The reproduction of symptoms in an animal model and in vitro studies of the cellular interactions and apoptosis of MRV2Tou05 ... we observed a signal directed against the λ proteins as well as 2 additional bands corresponding to the μ proteins (75 kDa and ... by confirming susceptibility to viral infection and clarifying the possible role of other common viruses in its pathogenicity. ... Binding to selected regions of reovirus mRNAs by a nonstructural reovirus protein. Proc Natl Acad Sci U S A. 1982;79:3457-61. ...
Human Genome Epidemiology Literature Finder|Home|PHGKB
DNA repair and apoptosis: Roles in radiotherapy-related acute reactions in breast cancer patients. Cellular and molecular ... XPC as breast cancer susceptibility gene: evidence from genetic profiling, statistical inferences and protein structural ... Current evidences on XPC polymorphisms and breast cancer susceptibility: a meta-analysis. Breast cancer research and treatment ... Association of XPC polymorphisms with susceptibility and clinical outcome to chemotherapy in breast cancer patients. Cancer ...
Sars-Cov-2 Kills T-Cells, Just Like HIV - by Igor Chudov
It turns out that HIVs gp120 protein is the one that "Activates LFA-1 on CD4 T-Lymphocytes and Increases Cell Susceptibility ... This depletion was caused by cellular suicide (apoptosis) of T cells after infection ... Additionally, gp120 protein is located in the spike protein of Sars-Cov-2, and spike protein is used in all "Covid vaccines". ... So, spike protein in Sars-Cov-2 has gp120, we know that it affects lymphocytes, and "Covid Vaccines" also make spike protein. ...
We investigated the consequences ofApocynum venetumleaf extract (AVLE) on depressive actions - biobender.com
... referred to as the main mediators of apoptosis widely. Among the suspected susceptibility genes mixed up in etiology of ... apoptotic proteins inside the cell . In response to tension, these proteins regulate the discharge of cyt-C, which in turn ... Depression is associated with impairments in structural plasticity and cellular atrophy , and volume decreases have been ... Apoptosis plays a key role in tissue homeostasis, and considerable evidence suggests that apoptosis and the molecular ...
About Syllabus - Jobriya
h) Veterinary Pathology:- Causes of diseases, haemodynamic derangements, cellular degeneration and necrosis, apoptosis, ... evaluation of protein quality for ruminants and non-ruminants. Non-protein nitrogen utilization in ruminants diets. Imp01iance ... Resistance and susceptibility of the host, Bacterial genetics, Plasmids, Antibiotic resistance. General prope11ies, Replication ... Energy and protein requirement for maintenance, growth, pregnancy, lactation, egg, wool and meat production, ...
Fight Aging! Newsletter, March 27th 2023 - Fight Aging!
... they either die by apoptosis or undergo irreversible cell proliferation arrest by induction of cellular senescence. These ... One such pathologic protein whose normal clearance is dependent on a healthy BBB is the 42 amino acid Aβ peptide (Aβ42), ... This accounts for the reduced ability of the elderly to respond to antigens and correlates with increased susceptibility to ... Cellular senescence is a major hallmark of senescence in organs and the whole body. Accumulated senescent cells in aged organs ...
Fluoride Action Network | Study Tracker
Categories: Bones/Joints, Bone Mineralization/Quality, Mechanism of Toxicity, Mechanisms of Cellular Toxicity, Apoptosis, ... Fluoride increases the susceptibility of developmental dysplasia of the hip via increasing capsular laxity triggered by cell ... fluoride in drinking water induce hypertrophy versus atrophy in mouse skeletal muscle via modulation of sarcomeric proteins.. ... Categories: Bones/Joints, Bone Cells, Mechanisms of Cellular Toxicity, DNA effects, Osteoblasts, Fluoridation ...
Microdissected Pyramidal Cell Proteomics of Alzheimer Brain Reveals Alterations in Creatine Kinase B-Type, 14-3-3-γ, and Heat...
2020). PERK-mediated induction of microRNA-483 disrupts cellular ATP homeostasis during the unfolded protein response. J. Biol ... Nelson, T. J., and Alkon, D. L. (2007). Protection against beta-amyloid-induced apoptosis by peptides interacting with beta- ... mossy fibre field size and determination of seizure susceptibility. Eur. J. Neurosci. 15, 1692-1706. doi: 10.1046/j.1460- ... Protein abundance ratios and SDs were calculated for all proteins containing at least one unique peptide. This was performed by ...
HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2...
The data suggest that HIPK2 plays a critical role in p53 mediated cellular responses by removing the p53 inhibitor protein Mdm2 ... Instead, HIPK2 leads to a downregulation of p53-induced Mdm2 protein and this may lead to stabilization of p53. Overexpression ... Overexpression of HIPK2 leads to an increase of p53 protein expression or stability, which becomes enhanced further in the ... via modification of the protein itself or its intracellular movement. ...
... or protein kinases are encoded by the genome? What are the largest genes and proteins? How similar are human proteins to those ... Pancreatic α- and β-cellular clocks have distinct molecular properties and impact on islet hormone secretion and gene ... Means to an End: Apoptosis and Other Cell Death Mechanisms. 11/02/2010. COLD SPRING HARBOR, N.Y. (Nov. 2, 2010) - One million ... Recombination hotspot stacks the DNA deck in finding a new diabetes susceptibility gene ...
... or protein kinases are encoded by the genome? What are the largest genes and proteins? How similar are human proteins to those ... Pancreatic α- and β-cellular clocks have distinct molecular properties and impact on islet hormone secretion and gene ... Recombination hotspot stacks the DNA deck in finding a new diabetes susceptibility gene 11/04/2010. The autoimmune disease type ... Means to an End: Apoptosis and Other Cell Death Mechanisms 11/02/2010. COLD SPRING HARBOR, N.Y. (Nov. 2, 2010) - One million ...
Oxidative stressChromosome SegregationProliferationSuppressMediatorsInhibitionSurvivalMeshPathwaysCytokineDifferentiationDownstreamCarcinogensApoptoticKinasesCysteineKinasePhosphorylationEnzymesReceptors2002ActivatorMechanismRegulatesDRUGSIncreasesAtrophySignaling moleculesModulationGenesRegulationFunctionsProcessesLigandsMolecularFamilyCellsRoleExposureGrowthMetabolismStudiesCancerDamageLiverIncludesEvidenceEssentialMajorSurfaceType
- Under oxidative stress conditions, excessive ROS can damage cellular proteins, lipids, and DNA, leading to cell damage that may contribute to carcinogenesis. (hindawi.com)
- Fluoride increases the susceptibility of developmental dysplasia of the hip via increasing capsular laxity triggered by cell apoptosis and oxidative stress in vivo and in vitro. (fluoridealert.org)
- CAS/CSE protein family includes the mammalian cellular apoptosis susceptibility (CAS) proteins and the yeast chromosome-segregation protein, CSE1. (mekineer.com)
- 1. Overexpression of far upstream element binding proteins: a mechanism regulating proliferation and migration in liver cancer cells. (nih.gov)
- Pimitespib, a heat shock protein 90α/ß inhibitor, and Telaglenastat, a selective glutaminase 1 inhibitor, inhibited proliferation of DeGISTL1 cells and the combination of these showed an additive effect. (bvsalud.org)
- CAS is involved in both cellular apoptosis and proliferation. (mekineer.com)
- These results suggest that altered and deficient p53 affects the cellular response to freshly fractured silica exposure, and thereby enhances susceptibility and augments cell proliferation and lung cancer development. (cdc.gov)
- At low and moderate levels ROS can act as signaling molecules that sustain cellular proliferation and differentiation and activate stress-responsive survival pathways [ 3 ]. (hindawi.com)
- Our results indicate that AVLE has potent antidepressant activity, likely due to its ability to suppress neuronal apoptosis. (biobender.com)
- These results reveal that an antiapoptotic role for the PI3K/Akt pathway induced by PCV2 contamination to suppress premature apoptosis for improved computer virus growth after contamination extending our understanding of the molecular mechanism of PCV2 contamination. (hiv-proteases.com)
- These results suggest that PCV2 contamination activates the PI3K/Akt pathway to suppress premature apoptosis for improved computer virus growth after contamination. (hiv-proteases.com)
- In response to tension, these proteins regulate the discharge of cyt-C, which in turn causes activation from the caspase category of cysteine proteases, referred to as the main mediators of apoptosis widely. (biobender.com)
- Several proteins identified in the latter study have been investigated as biomarkers and pathological mediators in AD (Hashimoto M. et al. (proquest.com)
- As a result, in today's research we hypothesized that AVLE may exert antidepressant results via the inhibition of neuronal apoptosis using the chronic unstable mild tension rat style of unhappiness. (biobender.com)
- Inhibition of PI3K activation prospects to reduced computer virus yield which is usually associated with decreased viral DNA replication and lower computer virus protein expression. (hiv-proteases.com)
- Inhibition of PI3K activation induced a lesser PCV2 virus produce aswell as reduced viral DNA deposition and proteins synthesis. (hiv-proteases.com)
- Furthermore this enhanced early apoptosis after inhibition of MGL-3196 PI3K activation could be largely overcome by the pancaspase inhibitor zVAD.fmk. (hiv-proteases.com)
- Research opportunities include identifying mechanisms of cellular injury and survival, understanding genetic factors influencing susceptibility, and identifying pharmacologic avenues for protection and rescue from NIHL. (nih.gov)
- Apoptosis plays a key role in tissue homeostasis, and considerable evidence suggests that apoptosis and the molecular mechanisms underlying cell death and survival are highly relevant to depressive disorder. (biobender.com)
- Virus infections activates web host cellular signaling pathways like the phosphatidylinositol 3-kinase (PI3K)/Akt pathway which regulates diverse cellular actions related to cell growth survival and apoptosis. (hiv-proteases.com)
- Cullin Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- Recent advances in the molecular biology of cancer, stemming from the study of cancer-causing viruses ('oncoviruses')and transforming DNA, are providing new ways of investigating cancer-forming genes ('oncogenes') and cellular pathways which are involved in the mechanisms of viral, chemical, and physical carcinogenesis. (dadamo.com)
- Reactive oxygen species (ROS) and their products are components of cell signaling pathways and play important roles in cellular physiology and pathophysiology. (hindawi.com)
- 2015 ). The binding of ligand to TLR resulted in the recruitment of several adaptor proteins and led to activation of many transcriptional factors which drive the expression of cytokine genes (Kawasaki and Kawai 2014 ). (springeropen.com)
- The approach is to encourage collaboration between nutrition and epigenetic /DNA methylation experts to study bioactive food components with cancer preventative properties, and to examine key epigenetic events in cancer processes (i.e., carcinogen metabolism, cell division, differentiation, apoptosis) so that investigators can begin to establish linkages between epigenetics, methylation pattern, and tumor incidence/behavior. (nih.gov)
- Taxol may increase cellular susceptibility to apoptosis by amplifying the normal downstream events associated with mitotic kinase activation. (nih.gov)
- Exposure to freshly fractured or aged silica produced divergent cellular responses in certain downstream cellular events, including ROS production, apoptosis, cell cycle and chromosomal changes, and gene expression. (cdc.gov)
- Many independent factors, such as gender, diet, age and a slew of environmental factors may have a modifying role in increasing, or decreasing, the susceptibility to carcinogens. (dadamo.com)
- Herein, we report that the anti-apoptotic protein, Bcl-2, undergoes cell cycle-dependent phosphorylation during mitosis when there is elevated Cdc2 activity. (nih.gov)
- The apoptotic process is programmed and managed by the total amount between pro- (Bax) and anti- (Bcl-2) apoptotic proteins inside the cell . (biobender.com)
- As a role for the PI3K/Akt pathway in virus-induced apoptotic replies of many various other viruses continues to be reported we also wished to know if the PI3K/Akt pathway is certainly involved with PCV2 infections and plays a part in PCV2-induced cell success and avoidance of apoptosis hence favoring virus development. (hiv-proteases.com)
- Manual 26.29 HN - 2002 MH - Activin Receptors UI - D029404 MN - D8.586.913.696.620.682.700.62 MN - D12.776.543.750.750.400.820.500 MS - Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). (nih.gov)
- 14-3-3-γ belongs to a highly conserved protein family mainly expressed in the brain where it regulates diverse functions by binding to kinases, signaling proteins, hydroxylases, and about 170 other ligands (Umahara et al. (proquest.com)
- H 2 O 2 is the more stable and diffusible form of ROS, it is selectively reactive towards cysteine residues on proteins, and, in the low nanomolar range, it can control cellular signaling (Figure 1 ). (hindawi.com)
- 12. P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation. (nih.gov)
- For instance, ROS can stimulate the phosphorylation of protein kinase C (PKC), p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase (ERK)1/2, phosphoinositide 3-kinase/serine-threonine kinase (PI3K/Akt), protein kinase B (PKB), and JUN N-terminal kinase (JNK) [ 4 - 6 ]. (hindawi.com)
- In addition we exhibited that PCV2 contamination induces the activation of JNK and p38 kinase and that MGL-3196 the activation of JNK and p38 pathway is usually involved in PCV2-induced apoptosis (63). (hiv-proteases.com)
- However, the role, if any, of prolonged Bcl-2 phosphorylation in Taxol-mediated apoptosis awaits further definition of Bcl-2 mechanism of action. (nih.gov)
- A variety of regulatory proteins including DNA methyltransferases, methyl-CpG binding proteins, histone- modifying enzymes, chromatin remodeling factors, and their multimolecular complexes are involved in the overall epigenetic process. (nih.gov)
- 2014). One such element is the amyloid β-peptide (Aβ), which is generated physiologically by proteolytic cleavage of the amyloid precursor protein (APP) by the enzymes β- and γ-secretase (De-Paula et al. (proquest.com)
- Gut microbes directly interact with the immune system by multiple mechanisms including modulation of the host microRNAs affecting gene expression at the post-transcriptional level or production of microbial metabolites that interact with cellular receptors such as TLRs and GPCRs. (frontiersin.org)
- The endothelin-1 (ET-1) receptors (ET-1R) ET A R and ET B R, members of G-protein coupled receptors (GPCR) family, are well-known drivers of tumor progression in many human malignancies, including OC 3 . (nature.com)
- Their deficiencies could impair innate immunity and increase susceptibility to infections (Chandra 2002 ). (springeropen.com)
- ROS are also involved in the increased expression of antioxidant genes related to the activation of transcription factors such as the nuclear factor erythroid 2-related factor 2 (Nrf2), activator protein 1 (AP-1), nuclear factor κ B (NF- κ B), hypoxia-inducible transcription factor 1a (HIF-1a), and p53 [ 7 - 9 ]. (hindawi.com)
- The incorporation of biologically active host proteins into HIV-1 is a well-established phenomenon, particularly due to the budding mechanism of viral egress in which viruses acquire their external lipid membrane directly from the host cell. (mdpi.com)
- While this mechanism might seemingly imply that host protein incorporation is a passive uptake of all cellular antigens associated with the plasma membrane at the site of budding, this is not the case. (mdpi.com)
- Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. (nih.gov)
- Many of our modern conveniences from drugs to cellular telephones have also received media attention for possible links to cancer. (dadamo.com)
- 2. Coordinated expression of stathmin family members by far upstream sequence element-binding protein-1 increases motility in non-small cell lung cancer. (nih.gov)
- Endonucleases damage increases the DNA migration, whereas DNA-DNA and DNA-protein cross-links result in retarded DNA migration, Tice, 2000. (gentaur.com)
- High concentration of sodium fluoride in drinking water induce hypertrophy versus atrophy in mouse skeletal muscle via modulation of sarcomeric proteins. (fluoridealert.org)
- Depression is associated with impairments in structural plasticity and cellular atrophy , and volume decreases have been observed in limbic, hippocampal, and prefrontal cortical brain regions . (biobender.com)
- The host responds to the presence of dividing bacteria by releasing numerous extra- and intra-cellular signaling molecules. (nih.gov)
- The modulation of intracellular ROS levels is crucial for cellular homeostasis, and different ROS levels can induce different biological responses. (hindawi.com)
- The goal would be to identify specific genes or groups of genes showing expression patterns that would warrant further follow-up in the search for the proteins that appear to be essential for the initiation, continuation, or resolution of the disease process. (nih.gov)
- Among the suspected susceptibility genes mixed up in etiology of unhappiness, evidence from scientific and preliminary research suggests a dysregulation from the pleiotropic transcription aspect cAMP response component binding proteins (CREB), and among its focus on genes, brain-derived neurotrophic aspect (BDNF) [9, 10]. (biobender.com)
- It is also associated with the regulation of APOPTOSIS and microtubule assembly. (nih.gov)
- A family of structurally related proteins that were originally discovered for their role in cell-cycle regulation in CAENORHABDITIS ELEGANS. (uchicago.edu)
- They play important roles in regulation of the CELL CYCLE and as components of UBIQUITIN-PROTEIN LIGASES. (uchicago.edu)
- Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular hpv high risk other genotype and regulation of immune responses. (thecroppers.ro)
- It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. (bvsalud.org)
- For example, several repair processes operate prior to DNA replication to remove the many types of DNA damage generated by endogenous cellular metabolism or exposure to the environment. (nih.gov)
- While external ligands include lipopeptides, lipopolysccharides (LPS), and bacterial flagellin (Ayres and Schneider 2012 ), internal ligands include hyaluronan, fibrinogen, heat shock proteins, and elements of damaged/fragmented DNA and RNA (Fig. 1 ) (Murad 2014 ). (springeropen.com)
- The role of p53 in silica -induced cellular and molecular responses associated with carcinogenesis. (cdc.gov)
- Moreover, AVLE (120?mg/kg) significantly increased Bcl-2, BDNF, and CREB protein expression and decreased Bax, cyt-C, and caspase family protein expression. (biobender.com)
- 6. PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells. (nih.gov)
- Phages infect prokaryotic cells by binding to surface proteins, injecting their DNA through the cell wall, and hijacking the cell's protein machinery to replicate the DNA. (mekineer.com)
- Furthermore, phosphorylated Bcl-2 remained complexed with Bax in Taxol-treated cells undergoing apoptosis. (nih.gov)
- Performed on Drosophila melanogaster cells or for human DNA damage studies for cancer susceptibility by environmental factors, food habits, sport. (gentaur.com)
- The more relevant factors include hypoxia, enhanced cellular metabolic activity, mitochondrial dysfunction, oncogene activity, increased activity of oxidases, lipoxygenases and cyclooxygenases, and the cross talk between cancer cells and immune cells recruited to the tumor site. (hindawi.com)
- Although ROS has been linked to apoptosis, DNA damage, and carcinogenesis, the role of enhanced ROS production by silica in silica -induced carcinogenesis is not completely understood. (cdc.gov)
- p53 protein was present in the BEAS-IIB and was absent in cancer cell lines after silica exposure. (cdc.gov)
- 5. Overexpression of far upstream element (FUSE) binding protein (FBP)-interacting repressor (FIR) supports growth of hepatocellular carcinoma. (nih.gov)
- In vitro analysis demonstrated that PIM and sunitinib combination therapy strongly inhibited growth and induced apoptosis in imatinib-resistant GIST cell lines by inhibiting KIT signaling and decreasing auto-phosphorylated KIT in the Golgi apparatus. (bvsalud.org)
- Availability and Utilization of Methyl Groups SAM and S-adenosylhomocysteine (SAH), as components of methyl metabolism, are the substrate and product of essential cellular methyltransferase reactions. (nih.gov)
- Apoptosis showed a comparable enhanced level of induction with freshly fractured or aged silica in both cancer lines with p53 functional changes. (cdc.gov)
- For measuring DNA damage from apoptosis, cell death by cytotoxicity and strand breaks at incomplete excision repair sites or alkali-labile sites about 6500 papers have been published in PubMed and identified by GENTAUR. (gentaur.com)
- Cellular repair resolves the DNA damage and nucleoids containing specific DNA and the breaks are tested with the comet assay. (gentaur.com)
- 14. 2-D DIGE profiling of hepatocellular carcinoma tissues identified isoforms of far upstream binding protein (FUBP) as novel candidates in liver carcinogenesis. (nih.gov)
- Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
- In other cases, the only evidence of a flare is a laboratory test showing a low white blood cell or platelet count or protein in the urine, for example. (nih.gov)
- Once identified, such gene products would represent new targets for the development of therapeutic agents that would block proteins essential to the disease process or augment proteins involved in resolving the infection and its sequelae. (nih.gov)
- GGPP is an intermediate on the mevalonate pathway, essential for the anchoring of Ras protein to the cell membranes ( Ref .). ( Here is a map showing where HMGCR and GGPP are located on the mevalonate pathway. (cancertreatmentsresearch.com)
- This graph shows the total number of publications written about "Cullin Proteins" by people in this website by year, and whether "Cullin Proteins" was a major or minor topic of these publications. (uchicago.edu)
- 2012). Together with neurofibrillary tangles (NFT) composed of hyperphosphorylated Tau protein, plaques composed of fibrillar Aβ is the major neuropathological hallmark of AD (Mott and Hulette, 2005). (proquest.com)
- We discuss how HIV-1 virions displaying host proteins on their surface can exhibit a myriad of altered phenotypes, with notable impacts on infectivity, homing, neutralization, and pathogenesis. (mdpi.com)
- 2010). CRISPR DNA sequences and their associated proteins are one such type of protection. (mekineer.com)