A nucleocytoplasmic transport protein that binds to ALPHA KARYOPHERINS and RAN GTP BINDING PROTEIN inside the CELL NUCLEUS and participates in their export into CYTOPLASM. It is also associated with the regulation of APOPTOSIS and microtubule assembly.
Crk-associated substrate was originally identified as a highly phosphorylated 130 kDa protein that associates with ONCOGENE PROTEIN CRK and ONCOGENE PROTEIN SRC. It is a signal transducing adaptor protein that undergoes tyrosine PHOSPHORYLATION in signaling pathways that regulate CELL MIGRATION and CELL PROLIFERATION.
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Toxins produced, especially by bacterial or fungal cells, and released into the culture medium or environment.
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small molecules. Transfer of ADP-ribose to water (i.e., hydrolysis) is catalyzed by the NADASES. The mono(ADP-ribose)transferases transfer a single ADP-ribose. POLY(ADP-RIBOSE) POLYMERASES transfer multiple units of ADP-ribose to protein targets, building POLY ADENOSINE DIPHOSPHATE RIBOSE in linear or branched chains.
An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.
Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
Short, predominantly basic amino acid sequences identified as nuclear import signals for some proteins. These sequences are believed to interact with specific receptors at the NUCLEAR PORE.
Proteins that form the structure of the NUCLEAR PORE. They are involved in active, facilitated and passive transport of molecules in and out of the CELL NUCLEUS.
Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING PROTEIN causes release of karyopherin beta.
An opening through the NUCLEAR ENVELOPE formed by the nuclear pore complex which transports nuclear proteins or RNA into or out of the CELL NUCLEUS and which, under some conditions, acts as an ion channel.
A family of proteins involved in NUCLEOCYTOPLASMIC TRANSPORT. Karyopherins are heteromeric molecules composed two major types of components, ALPHA KARYOPHERINS and BETA KARYOPHERINS, that function together to transport molecules through the NUCLEAR PORE COMPLEX. Several other proteins such as RAN GTP BINDING PROTEIN and CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN bind to karyopherins and participate in the transport process.
The orderly segregation of CHROMOSOMES during MEIOSIS or MITOSIS.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
A sulfhydryl reagent that is widely used in experimental biochemical studies.
A monomeric GTP-binding protein involved in nucleocytoplasmic transport of proteins into the nucleus and RNA into the cytoplasm. This enzyme was formerly listed as EC 3.6.1.47.
A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
Protein factors that promote the exchange of GTP for GDP bound to GTP-BINDING PROTEINS.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The field of medicine concerned with understanding the biochemical basis of health and disease and involved in developing diagnostic and therapeutic methods that utilize MOLECULAR BIOLOGY techniques.
Gated transport mechanisms by which proteins or RNA are moved across the NUCLEAR MEMBRANE.
Discarded electronic devices containing valuable and sometimes hazardous materials such as LEAD, NICKEL, CADMIUM, and MERCURY. (from http://www.epa.gov/osw/conserve/materials/ecycling/faq.htm#impact accessed 4/25/2010)
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal PRIONS. These diseases are characterized by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature DEMENTIA; ATAXIA; and a fatal outcome. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The older literature occasionally refers to these as unconventional SLOW VIRUS DISEASES. (From Proc Natl Acad Sci USA 1998 Nov 10;95(23):13363-83)
Normal cellular isoform of prion proteins (PRIONS) encoded by a chromosomal gene and found in normal and scrapie-infected brain tissue, and other normal tissue. PrPC are protease-sensitive proteins whose function is unknown. Posttranslational modification of PrPC into PrPSC leads to infectivity.
Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
Abnormal isoform of prion proteins (PRIONS) resulting from a posttranslational modification of the cellular prion protein (PRPC PROTEINS). PrPSc are disease-specific proteins seen in certain human and animal neurodegenerative diseases (PRION DISEASES).
Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)

Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. (1/50)

Importin alpha plays a pivotal role in the classical nuclear protein import pathway. Importin alpha shuttles between nucleus and cytoplasm, binds nuclear localization signal-bearing proteins, and functions as an adapter to access the importin beta-dependent import pathway. In contrast to what is found for importin beta, several isoforms of importin alpha, which can be grouped into three subfamilies, exist in higher eucaryotes. We describe here a novel member of the human family, importin alpha7. To analyze specific functions of the distinct importin alpha proteins, we recombinantly expressed and purified five human importin alpha's along with importin alpha from Xenopus and Saccharomyces cerevisiae. Binding affinity studies showed that all importin alpha proteins from humans or Xenopus bind their import receptor (importin beta) and their export receptor (CAS) with only marginal differences. Using an in vitro import assay based on permeabilized HeLa cells, we compared the import substrate specificities of the various importin alpha proteins. When the substrates were tested singly, only the import of RCC1 showed a strong preference for one family member, importin alpha3, whereas most of the other substrates were imported by all importin alpha proteins with similar efficiencies. However, strikingly different substrate preferences of the various importin alpha proteins were revealed when two substrates were offered simultaneously.  (+info)

Recycling of importin alpha from the nucleus is suppressed by loss of RCC1 function in living mammalian cells. (2/50)

We previously reported that the nuclear import of substrates containing SV40 T antigen nuclear localization signal (NLS) was suppressed in a temperature-sensitive RCC1 mutant cell line, tsBN2, at nonpermissive temperature. Moreover, it was shown that import into wild type BHK21 cell-derived nuclei gradually decreased in heterokaryons between the tsBN2 and BHK21 cells, although the BHK21 nuclei retained wild type RCC1 and should contain RanGTP (Tachibana et al., 1994). In this study, it was found that in the heterokaryons cultured at non-permissive temperature, endogenous importin alpha was not detected immunocytochemically in the cytoplasm or BHK21 nuclei but only in the tsBN2 nuclei, suggesting that importin alpha cannot be exported from the RCC1-depleted nuclei. In fact, importin alpha microinjected into the nucleus of tsBN2 cells at non-permissive temperature remained in the nucleus. These results strongly support the hypothesis that the recycling of importin alpha from the nucleus requires nuclear RanGTP. Moreover, it was found that cytoplasmic injection of importin alpha restored the import of SV40 T-NLS substrates in the BHK21 nuclei but not the tsBN2 nuclei in the heterokaryons. This indicates that the decrease of importin alpha from the cytoplasm in the heterokaryons leads to a suppression of the efficiency of nuclear import of the T-NLS substrate and provides support for the view that nuclear RanGTP is essential for the nuclear entry of the substrates.  (+info)

Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export. (3/50)

We present here a detailed analysis of a rat polypeptide termed Nup50 (formerly NPAP60) that was previously found to be associated with the nuclear pore complex (F. Fan et al., Genomics 40:444-453, 1997). We have found that Nup50 (and/or a related 70-kDa polypeptide) is present in numerous rat cells and tissues. By immunofluorescence microscopy, Nup50 was found to be highly concentrated at the nuclear envelope of rat liver nuclei, whereas in cultured NRK cells it also is abundant in intranuclear regions. On the basis of immunogold electron microscopy of both rat liver nuclear envelopes and NRK cells, we determined that Nup50 is specifically localized in the nucleoplasmic fibrils of the pore complex. Microinjection of anti-Nup50 antibodies into the nucleus of NRK cells resulted in strong inhibition of nuclear export of a protein containing a leucine-rich nuclear export sequence, whereas nuclear import of a protein containing a classical nuclear localization sequence was unaffected. Correspondingly, CRM1, the export receptor for leucine-rich export sequences, directly bound to a fragment of Nup50 in vitro, whereas several other import and export receptors did not significantly interact with this fragment. Taken together, our data indicate that Nup50 has a direct role in nuclear protein export and probably serves as a binding site on the nuclear side of the pore complex for export receptor-cargo complexes.  (+info)

G(i)-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways. (4/50)

Since blood platelets release sphingosine 1-phosphate (Sph-1-P) upon activation, it is important to examine the effects of this bioactive lipid on vascular endothelial cell functions from the viewpoint of platelet-endothelial cell interactions. In the present study, we examined Sph-1-P-stimulated signaling pathways related to human umbilical vein endothelial cell (HUVEC) motility, with a special emphasis on the cytoskeletal docking protein Crk-associated substrate (Cas). Sph-1-P stimulated tyrosine phosphorylation of Cas, which was inhibited by the G(i) inactivator pertussis toxin but not by the Rho inactivator C3 exoenzyme or the Rho kinase inhibitor Y-27632. Fyn constitutively associated with and phosphorylated Cas, suggesting that Cas tyrosine phosphorylation may be catalyzed by Fyn. Furthermore, upon HUVEC stimulation with Sph-1-P, Crk, through its SH2 domain, interacted with tyrosine-phosphorylated Cas, and the Cas-Crk complex translocated to the cell periphery (membrane ruffles), through mediation of G(i) (Fyn) but not Rho. In contrast, tyrosine phosphorylation of focal adhesion kinase, and formation of stress fibers and focal adhesion were mediated by Rho but not G(i) (Fyn). Finally, Sph-1-P-enhanced HUVEC motility, assessed by a phagokinetic assay using gold sol-coated plates and a Boyden's chamber assay, was markedly inhibited not only by pertussis toxin (or the Fyn kinase inhibitor PP2) but also by C3 exoenzyme (or Y-27632). In HUVECs stimulated with Sph-1-P, these data suggest the following: (i) cytoskeletal signalings may be separable into G(i)-mediated signaling pathways (involving Cas) and Rho-mediated ones (involving FAK), and (ii) coordinated signalings from both pathways are required for Sph-1-P-enhanced HUVEC motility. Since HUVECs reportedly express the Sph-1-P receptors EDG-1 (coupled with G(i)) and EDG-3 (coupled with G(13) and G(q)) and the EDG-3 antagonist suramin was found to block specifically Rho-mediated responses, it is likely that Cas-related responses following G(i) activation originate from EDG-1, whereas Rho-related responses originate from EDG-3.  (+info)

Identification of residues in the N-terminal domain of the Yersinia tyrosine phosphatase that are critical for substrate recognition. (5/50)

YopH is a 468-amino acid protein-tyrosine phosphatase that is produced by pathogenic Yersinia species. YopH is translocated into host mammalian cells via a type III protein secretion system. Translocation of YopH into human epithelial cells results in dephosphorylation of p130(Cas) and paxillin, disruption of focal adhesions, and inhibition of integrin-mediated bacterial phagocytosis. Previous studies have shown that the N-terminal 129 amino acids of YopH comprise a bifunctional domain. This domain binds to the SycH chaperone in Yersinia to orchestrate translocation and to tyrosine-phosphorylated target proteins in host cells to mediate substrate recognition. We used random mutagenesis in combination with the yeast two-hybrid system to identify residues in the YopH N-terminal domain that are involved in substrate-binding activity. Four single codon changes (Q11R, V31G, A33D, and N34D) were identified that interfered with binding of the YopH N-terminal domain to tyrosine-phosphorylated p130(Cas) but not to SycH. These mutations did not impair YopH translocation into HeLa cells infected with Yersinia pseudotuberculosis. Introduction of the V31G substitution into catalytically inactive (substrate-trapping) forms of YopH interfered with the ability of these proteins to bind to p130(Cas) and to localize to focal adhesions in HeLa cells. In addition, the V31G substitution reduced the ability of catalytically active YopH to dephosphorylate target proteins in HeLa cells. These data indicate that the substrate- and SycH-binding activities of the YopH N-terminal domain can be separated and that the former activity is important for recognition and dephosphorylation of substrates by YopH in vivo.  (+info)

Cse1l is essential for early embryonic growth and development. (6/50)

The CSE1L gene, the human homologue of the yeast chromosome segregation gene CSE1, is a nuclear transport factor that plays a role in proliferation as well as in apoptosis. CSE1 and CSE1L are essential genes in Saccharomyces cerevisiae and mammalian cells, as shown by conditional yeast mutants and mammalian cell culture experiments with antisense-mediated depletion of CSE1L. To analyze whether CSE1L is also essential in vivo and whether its absence can be compensated for by other genes or mechanisms, we have cloned the murine CSE1L gene (Cse1l) and analyzed its tissue- and development-specific expression: Cse1l was detected at embryonic day 7.0 (E7.0), E11.0, E15.0, and E17.0, and in adults, high expression was observed in proliferating tissues. Subsequently, we inactivated the Cse1l gene in embryonic stem cells to generate heterozygous and homozygous knockout mice. Mice heterozygous for Cse1l appear normal and are fertile. However, no homozygous pups were born after interbreeding of heterozygous mice. In 30 heterozygote interbreeding experiments, 50 Cse1l wild-type mice and 100 heterozygotes were born but no animal with both Cse1l alleles deleted was born. Embryo analyses showed that homozygous mutant embryos were already disorganized and degenerated by E5.5. This implicates with high significance (P < 0.0001, Pearson chi-square test) an embryonically lethal phenotype of homozygous murine CSE1 deficiency and suggests that Cse1l plays a critical role in early embryonic development.  (+info)

Functions of the adapter protein Cas: signal convergence and the determination of cellular responses. (7/50)

Since Cas was first identified as a highly phosphorylated 130 kilodalton protein that associated with the v-Src and v-Crk-oncoproteins, considerable effort has been made to determine its function. Its predicted role as a scaffolding molecule based on its domain structure has been largely confirmed. Through its ability to undergo rapid changes in phosphorylation, subcellular localization and association with heterologous proteins, Cas may spatially and temporally regulate the function of its binding partners. Numerous proteins have been identified that bind to Cas in vitro and/or in vivo, but in only a few cases is there an understanding of how Cas may function in these protein complexes. To date, Cas-Crk and Cas-Src complexes have been most frequently implicated in Cas function, particularly in regards to processes involving regulation of the actin cytoskeleton and proliferation. These and other Cas protein complexes contribute to the critical role of Cas in cell adhesion, migration, proliferation and survival of normal cycling cells. However, under conditions in which these processes are deregulated, Cas appears to play a role in oncogenic transformation and perhaps metastasis. Therefore, in its capacity as an adapter protein, Cas serves as a point of convergence for many distinct signaling inputs, ultimately contributing to the generation of specific cellular responses.  (+info)

Characterization of the nuclear export signal of polypyrimidine tract-binding protein. (8/50)

The polypyrimidine tract-binding protein (PTB) is a nuclear protein that regulates alternative splicing. In addition, it plays a role in the cytoplasm during infection by some viruses and functions as a positive effector of hepatitis B virus RNA export. Thus, it presumably contains a nuclear export signal (NES). Using a heterokaryon export assay in transfected cultured cells, we have shown that the N-terminal 25 amino acid residues of PTB function as an autonomous NES, with residues 11-16 being important for its activity. Unlike the heteronuclear ribonucleoprotein A1 NES, this NES is separable from the nuclear localization signal, which spans the entire N-terminal 60 residues of PTB. The PTB NES cannot be shown to bind to CAS or Crm1, cellular receptors known to export proteins from the nucleus, and it functions in the presence of leptomycin B, a specific inhibitor of Crm1-dependent export. PTB deleted of its NES, unlike wild type PTB, does not stimulate the export of hepatitis B virus RNA. Therefore, the PTB NES is a functionally important domain of this multifunctional protein that utilizes an unknown export receptor.  (+info)

Description: Cellular apoptosis susceptibility protein, the product of the CAS gene, is associated with microtubules and the mitotic spindle. CAS is the human homologue of the yeast chromosome-segregation gene, CSE-1. The molecular mechanism or function by which CAS is associated with cell proliferation and apoptosis is not yet fully understood. High expression of cytoplasmic CAS protein appears to correlate with proliferation of lymphoid cells. CAS expression may be useful in the identification of proliferating cells and in the elucidation of the function of cellular apoptosis.. Primary Antibody. ...
Cellular Apoptosis Susceptibility Protein: A nucleocytoplasmic transport protein that binds to ALPHA KARYOPHERINS and RAN GTP BINDING PROTEIN inside the CELL NUCLEUS and participates in their export into CYTOPLASM. It is also associated with the regulation of APOPTOSIS and microtubule assembly.
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The IPL1 gene is required for high-fidelity chromosome segregation in the budding yeast Saccharomyces cerevisiae. Conditional ipl1ts mutants missegregate chromosomes severely at 37 degrees C. Here, we report that IPL1 encodes an essential putative protein kinase whose function is required during the later part of each cell cycle. At 26 degrees C, the permissive growth temperature, ipl1 mutant cells are defective in the recovery from a transient G2/M-phase arrest caused by the antimicrotubule drug nocodazole. In an effort to identify additional gene products that participate with the Ipl1 protein kinase in regulating chromosome segregation in yeast, a truncated version of the previously identified DIS2S1/GLC7 gene was isolated as a dosage-dependent suppressor of ipl1ts mutations. DIS2S1/GLC7 is predicted to encode a catalytic subunit (PP1C) of type 1 protein phosphatase. Overexpression of the full-length DIS2S1/GLC7 gene results in chromosome missegregation in wild-type cells and exacerbates the ...
Given the availability of TALE-based or nuclease-defective Cas9 (dCas9)-based designed transcription factor systems, which is better?. Gao et al (2014) publish their investigations into this problem in Nucleic Acids Research in the context of mouse embryonic fibroblast cells in vitro.. Using a number of gene expression metrics including luciferase assays, endogenous gene expression measurements and induction pluripotent stem cells Gao et al. found each system had their own characteristics. Clearly CRISPR/Cas9 was more cost effective, scalable and capable of trageting multiple loci but the TALE system has the advantage of customizable length of DNA binding domain. (from Gao et al.). Performance of these two systems was also distinguishable with dCas9-Activators consistently less effective than TALE-Acitvators of transcription while, on the other hand, dCas9-Repressors were as good or better than TALE-Repressors of transcription. The authors report that binding of dCas9 resulted in physical ...
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Baxter J, Aragón L, 2010, Physical linkages between sister chromatids and their removal during yeast chromosome segregation., Cold Spring Harb Symp Quant Biol, Vol: 75, Pages: 389-394 The fidelity of chromosome inheritance is of paramount importance to all living organisms. In eukaryotic cells, the strategy to ensure physical segregation of chromosomes to daughter cells relies on two basic steps ordered in time: an initial linkage, or cohesion, of sister chromatids and its timely and complete dissolution during anaphase. The current view is that these two basic steps are accomplished around the regulation of a protein complex called cohesin that serves as clamp brackets distributed at intervals throughout the genome. However, many of the DNA metabolic activities during interphase also produce physical linking of chromatids. For example, during replication, intertwines between sister chromatids are formed. Here, we review our understanding of the processes that generate physical linkages ...
Plasmid dCas9-KRAB-MeCP2 from Dr. George Churchs lab contains the insert dCas9-KRAB-MeCP2 and is published in Nat Methods. 2018 Jul 16. pii: 10.1038/s41592-018-0048-5. doi: 10.1038/s41592-018-0048-5. This plasmid is available through Addgene.
I love solving mysteries and problems, which is how I would describe what I do for a living. Technically speaking, I am a biochemist - a structural biologist. I like looking at the 3-dimensional structure of proteins and understanding how other things (other proteins, DNA, small molecules, etc) fit into those proteins. And while I have some interest in understanding the biological processes of cancer, I am not a cancer researcher. However, I have been spending a lot of my spare time trying to understanding more about BRCA2 (pronounced as bracka two and stands for Breast Cancer Type 2 susceptibility protein). For most genes and proteins, the gene is in italics while the protein remains in normal font.. BRCA2 was discovered in 1995 by Professor Michael Stratton and Dr. Richard Wooster in cooperation with the Wellcome Trust Sanger Institute. This institute is a charitably funded genomic research center and is located about 9 miles south of Cambridge in a town called Hinxton. The Sanger Institute ...
human HCCA2 protein: activates NDR1; suppressed expression in a subpopulation of cortical pyramidal neurons in the Alzheimer Disease brain; do not confuse with human hepatocellular carcinoma susceptibility protein, also known as HCCA2 and YAP; RefSeq NM_053005
Plasmid pCXLE-dCas9VP192-T2A-EGFP from Dr. Timo Otonkoskis lab contains the insert dCas9-dCas9VP192-EGFP and is published in Stem Cell Reports. 2015 Sep 8;5(3):448-59. doi: 10.1016/j.stemcr.2015.08.001. This plasmid is available through Addgene.
Prices shown reflect U.S. list pricing for orders shipped to U.S. addresses. Non-U.S. pricing may vary depending on geography. Please contact [email protected] for a quote or check our distributor page to see if Cellecta has an authorized reseller in your region. ...
After transfection with sgRNA-guided dCas9-E, the BM-MSCs acquired significantly higher transcription and expression of EDA by doxycycline (Dox) induction. Intriguingly, the specific markers (CEA, CK7, CK14, and CK19) of sweat glands were also positive in the transfected BM-MSCs, suggesting that EDA plays a critical role in promoting BM-MSC differentiation into sweat glands. Furthermore, when the dCas9-E BM-MSCs with Dox induction were implanted into a wound in a laboratory animal model, iodine-starch perspiration tests revealed that the treated paws were positive for perspiration, while the paws treated with saline showed a negative manifestation. For the regulatory mechanism, the expression of downstream genes of NF-κB (Shh and cyclin D1) was also enhanced accordingly.. CONCLUSIONS ...
Mammalian Cas proteins regulate cell migration, division and survival, and are often deregulated in cancer. However, the presence of four paralogous Cas family members in mammals (BCAR1/p130Cas, EFS/Sin1, NEDD9/HEF1/Cas-L, and CASS4/HEPL) has limited their analysis in development. We deleted the single Drosophila Cas gene, Dcas, to probe the developmental function of Dcas. Loss of Dcas had limited effect on embryonal development. However, we found that Dcas is an important modulator of the severity of the developmental phenotypes of mutations affecting integrins (If and mew) and their downstream effectors Fak56D or Src42A. Strikingly, embryonic lethal Fak56D-Dcas double mutant embryos had extensive cell polarity defects, including mislocalization and reduced expression of E-cadherin. Further genetic analysis established that loss of Dcas modified the embryonal lethal phenotypes of embryos with mutations in E-cadherin (Shg) or its signaling partners p120- and beta-catenin (Arm). These results ...
dCas9 binds DNA complementary to its guide RNA (gRNA). The location it binds to may therefore be controlled by producing specific gRNAs.. By targeting dCas9 fused to a RNAP recruiting subunit (dCas9-ω) to an adequate distance from the transcription starting site (TSS), PAM-rich_J23117 (BBa_K1723001) was successfully induced, which represents a PNP transistor in on state.. The bio-transistor was designed to produce GFPmut2. Promoter activity for each input combination was assessed by measuring Relative Fluorescence Units (RFU) and normalised by OD600 which should be correlate linearly to the promoters strength [1].. We chose to test two sites close enough to the TSS to (likely) sterically hinder RNA Polymerase (RNAP) attachement when bound by dCas9-ω. By itself, targeting dCas9-ω to inhibition sites (R1, R2), sometimes resulted in slight activation (experiment 3) and sometimes in slight inhibition (experiment 1). This might be explained by the already low promoter strength of J23117 (close ...
Plasmids, strains and primers used in this study are listed in Additional file 7: Table S1, Additional file 8: Table S2, Additional file 9: S3 1. Oligonucleotides and gBlocks were ordered from IDT and Eurofins. All fragments obtained by PCR were gel- or column purified (Nucleospin® Gel and PCR Clean-up columns) before cloning, and resulting plasmids were verified by sequencing (Eurofins). Yeast transformations were done using lithium acetate and PEG3350, and genomic integrations were performed with various helper plasmids and pre-expressed iCas9 from plasmid pCT (Addgene #60620) and plated on Sc-Leu+cloNAT. Strains were cured for pCT and helper plasmids after genome engineering and before proceeding to transcriptional regulation using dCas9.. EasyClone-MarkerFree vectors pCfB2909, pCfB3035, pCfB3037 and helper plasmids pCfB3042, pCfB3046, and pCfB3050 as well as genomic integration verification primers were adapted as previously described [46]. Yeast strains were plated according to ...
Control of DSB formation and meiotic CO repair is crucial for execution of the meiotic program. Too few, or too many, COs, COs placed at the wrong location, or DSB formation within at-risk regions jeopardize genome stability (Sasaki et al. 2010). Many factors influence CO formation, either by influencing DSB activity or post-DSB repair decisions (Keeney 2001; Hunter 2015), and manipulating these factors leads to global DSB and/or recombination effects. In addition, localized systems that control recombination within specific genomic regions exist (e.g., Ellermeier et al. 2010; Vader et al. 2011; Vincenten et al. 2015; Nambiar and Smith 2018). One such localized mechanism is kinetochore-derived, and minimizes DSB activity and CO formation within pericentromeres (Vincenten et al. 2015). Here, we shed light on this mechanism. We developed a dCas9-based system to target individual kinetochore/Ctf19c subunits, and to dissect the mechanism of kinetochore-driven CO regulation. Using this system, we ...
To ensure that the attached RNA module both retains targeting functionality as well as the resulting complex drive transcriptional activation at a specific site of interest, transient reporter gene expression of luciferase and fluorescent protein was measured. Two variations of such a transcription activator assay was performed; directly with a dCas9 fused to a transcriptional activator/repressor (VP64, a factor known to enhance gene expression) (Direct activation) or indirectly where the transcriptional activator is fused to an RNA binding protein module on the sgRNA (Bridged activation). Reporter gene activation through direct activation imply the sgRNA variant binds and targets dCas9 efficiently. All the five topologies showed direct activation except TOP3 and TOP4, which showed reduced activity. Bridged activation indicates that the fused RNA accessory domain is intact in mature dCas9 complexes. Bridged activation was observed with TOP1, TOP3 and INT. The results were recapitulated at ...
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In addition to the Cas9 protein that bacteria use to bind ... DNA, bacteria have other Cas proteins that know where to insert ... team has discovered how these proteins -- Cas1 and Cas2 -- locate and ...
We sell ELISA, IFA, RIA kits, antibody/antibodies for many antigens and hosts, IgA, IgD, IgE, IgG, IgM. Antibody application for WB, ELISA, IHC-P, IF, FCM.
Mutations in the breast cancer susceptibility protein, BRCA1, are heavily implicated in familial breast and ovarian cancers that are classified as triple negati...
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR ...
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR ...
DNA methylation is an essential DNA modification that plays a crucial role in genome regulation during differentiation and development, and is disrupted in a range of disease states. The recent development of CRISPR/catalytically dead CRISPR/Cas9 (dCas9)-based targeted DNA methylation editing tools has enabled new insights into the roles and functional relevance of this modification, including its importance at regulatory regions and the role of aberrant methylation in various diseases. However, while these tools are advancing our ability to understand and manipulate this regulatory layer of the genome, they still possess a variety of limitations in efficacy, implementation, and targeting specificity. Effective targeted DNA methylation editing will continue to advance our fundamental understanding of the role of this modification in different genomic and cellular contexts, and further improvements may enable more accurate disease modeling and possible future treatments. In this review, we ...
I have a lot more to say on the organizational issues here, but that last section was getting too long anyway, and I figured this would be a good place to change subjects entirely. That is why I want to talk about distributed coordinated attacks (DCAs). For those of you who havent read about this sort of attack, you will be hearing about it soon. As of this writing, a few initial tools have been widely distributed over the Internet to allow attackers to break into site after site and plant Trojan Horses there which are designed to be remotely controlled. These tools generate a series of remotely exploitable hosts and then provide the means for their use to attack targets of choice as commanded by their originator. By the time this article hits paper form, you will likely have heard a lot more about them, and you may even be one of those affected by them. Now the important thing to note about DCAs from the standpoint of this discussion is that defense against them requires a distributed ...
Read independent reviews on Science IP - Online Scientific Literature and Patent Search from Chemical Abstracts Service (CAS) on SelectScience
High-throughput genetic screens are powerful methods to identify genes linked to a given phenotype. The catalytic null mutant of the Cas9 RNA-guided nuclease (dCas9) can be conveniently used to silence genes of interest in a method also known as CRISPRi. Here, we report a genome-wide CRISPR-dCas9 sc …
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গুণ স্থানীয় অবেদনবিদ নির্মাতারা & রপ্তানিকারক - কেনা 99% বিশুদ্ধ সাদা বৃদ্ধি হরমোন পাউডার CAS 73-78-9 লিডোকাইন হাইড্রোক্লোরাইড চীন থেকে উত্পাদক.
গুণ স্থানীয় অ্যানেশথিক ড্রাগস নির্মাতারা & রপ্তানিকারক - কেনা ফার্মেসি CAS 132112-35-7 জন্য রপাইয়েসিনা এইচ এইচ স্থানীয় অ্যানেশেশিয়া ঔষধ চীন থেকে উত্পাদক.
Tetrahydrothiopyran-4-one S,S-dioxide,CAS#:17396-35-9/4-Chloropyrimidine hydrochloride, CAS#:17180-93-7/Ethyl 3,3-diethoxypropionate,CAS#:10601-80-6
2019年の世界のハイドロタルサイトの生産量は約81,926トンで、2026年には106,591トンに達する見込みです。一方、収益は2019年に2億2,240万米ドルで、2026年には3億1,100万米ドルとなり、2021年から2026年の間にCAGR5.5%で拡大する見込みです。
Restekの検索可能なクロマトグラムライブラリはRestekの化学者、パートナー、お客様のアプリケーションから得た、多数のクロマトグラムの総合的なデータベースです。 当社の独自のライブラリは、化合物名、同義語、CAS #、化合物クラス、Restekまたは競合のカラム名、カタログ番号、またはキーワードでクロマトグラムを検索できます。 結果を絞るためにもっと検索用語を使えます。ライブラリのサイドバー内のリンクを使って検索結果を素早く絞り込むことも可能です。 ここに示すアプリケーションに関して質問があれば、Restekのテクニカルサービスグループにご連絡ください。. ...
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR ...
Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous recombination is therefore controlled by chromatin. ...
BRCA1 / RNF53, 50 µg. BRCA1 (breast and ovarian cancer susceptibility protein 1) is a RING finger protein containing a BRCT domain.
BRCA1 / RNF53, 50 µg. BRCA1 (breast and ovarian cancer susceptibility protein 1) is a RING finger protein containing a BRCT domain.
PND-1186, also known as SR-2156 and VS-4718, is a potent FAK inhibitor with a 50% inhibitory concentration (IC50) of 1.5 nM in vitro. PND-1186 has an IC50 of ~100 nM in breast carcinoma cells. Notably, 1.0 µM PND-1186 (|5-fold above IC50) had limited effects on cell proliferation. However, under non-adherent conditions as spheroids and as colonies in soft agar, 0.1 µM PND-1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase-3 activation, and triggered cell apoptosis. PND-1186 inhibited 4T1 breast carcinoma subcutaneous tumor growth correlated with elevated tumor cell apoptosis and caspase 3 activation.
A core concept of synthetic biology is controlling gene expression, often achieved through inducers and protein repressors to create feedback loops and switches. Our team has combined the CRISPRi system with RNA regulators to achieve a toggle switch. The switch utilizes the catalytically inactive form of Cas9 (dCas9) to achieve targeted and reversible repression of genes via specific single-guide RNAs (sgRNAs). Alternatively, the transcription of antisense RNA (asRNAs) reverses the effect of the dCas9 modulated repression on the desired genes ...
CAS Number, CAS NO. Search, cas no. of chemicals Search,cas number database free for lookchem-CasNo list - 1,141743-14-8,141504-13-4
CAS Number, CAS NO. Search, cas no. of chemicals Search,cas number database free for lookchem-CasNo list - 8,813439-58-6,81168-17-4
Listing of chemicals CAS Number: 129885-04-7 through CAS Number: 1343-88-0 with links to more detailed information for each chemical.
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CAS NO:20151-40-0; Chemical name:2,4-Dibromoquinoline ; physical and chemical property of 20151-40-0, 2,4-Dibromoquinoline is provided by ChemNet.com
CAS NO:1004-38-2; Chemical name:2,4,6-Triaminopyrimidine ; physical and chemical property of 1004-38-2, 2,4,6-Triaminopyrimidine is provided by ChemNet.com
DCPLA-ME 是 DCPLA 的甲酯形式。DCPLA-ME 是一种有效的 PKCε 激活剂。DCPLA-ME 可用于治疗神经退行性疾病 ...
香豆素-3-羧酸乙酯 Ethyl 3-coumarincarboxylate 是一种香豆素衍生物。Ethyl 3-coumarincarboxylate 可作为伪模板,用于制备对黄曲霉毒素具有较为特异性识别能力的分子印迹聚合物 (MIP ...
Products CAS number 2,3-Dibromosuccinic acid 526-78-3 2-Bromoacetic acid 79-08-3 2-Bromobutyric acid 80
CAS (cellular apoptosis susceptibility protein) is part of the importin-β superfamily of karyopherins and is defined as a ... but the key proteins involved had not been elucidated up until that point. A 60 kDa cytosolic protein, essential for protein ... Many different cargo proteins can be transported into the nucleus by importin. Often, different proteins will require different ... breast cancer type 1 susceptibility protein), into the nucleus. The overexpression of importin-α has also been linked with poor ...
Then the cellular apoptosis susceptibility protein (CAS), an exportin which in the nucleus is bound to RanGTP, displaces ... The proteins that make up the nuclear pore complex are known as nucleoporins; each NPC contains at least 456 individual protein ... This remodelling seems to allow the protein complex cdc2/cyclinB to enter the nucleus as well as many other proteins, such as ... Each of the eight protein subunits surrounding the actual pore (the outer ring) projects a spoke-shaped protein over the pore ...
... cellular apoptosis susceptibility protein MeSH D12.776.543.585.750.500 - karyopherins MeSH D12.776.543.585.750.500.100 - alpha ... gtp-binding protein alpha subunit, gi2 MeSH D12.776.543.325.100.300 - gtp-binding protein alpha subunits, gq-g11 MeSH D12.776. ... proto-oncogene proteins c-kit MeSH D12.776.543.750.060.186 - proto-oncogene proteins c-met MeSH D12.776.543.750.060.217 - proto ... q-snare proteins MeSH D12.776.543.512.249.500.500 - qa-snare proteins MeSH D12.776.543.512.249.500.500.700 - syntaxin 1 MeSH ...
"Cas Proteins". www.sinobiological.com. Retrieved 2019-12-04. Cellular+Apoptosis+Susceptibility+Protein at the US National ... The Cas family of proteins are a family of proteins that induce cellular apoptosis and cell proliferation. Apoptosis is a ... The cellular apoptosis susceptibility protein (CAS) is an exportin which in the nucleus is bound to RanGTP. ... ALong with this correlation, in the absence of the CAS protein in a cell, there is an inhibition of apoptosis Along with being ...
Cellular apoptosis susceptibility protein. *E2F. *Maturation promoting factor. *Wee. *Cullin (CUL7). Phases and. checkpoints. ... protein kinase inhibitor activity. • protein kinase binding. • macromolecular complex binding. Cellular component. • cytoplasm ... protein binding. • cyclin-dependent protein serine/threonine kinase inhibitor activity. • ubiquitin protein ligase binding. • ... This article is about the p21Cip1 protein. For the p21/ras protein, see Ras (protein). For other uses, see P21 (disambiguation) ...
Cellular apoptosis susceptibility protein. *E2F. *Maturation promoting factor. *Wee. *Cullin (CUL7). Phases and. checkpoints. ... Motor proteins then push the centrosomes along these microtubules to opposite sides of the cell. Although centrosomes help ... Volume 15 of Protein Reviews. Berlin: Springer Science & Business Media. p. 15. ISBN 9781461405146.. ... Prescott DM, Bender MA (March 1962). "Synthesis of RNA and protein during mitosis in mammalian tissue culture cells". ...
Cellular apoptosis susceptibility protein. *E2F. *Maturation promoting factor. *Wee. *Cullin (CUL7). Phases and. checkpoints. ... MPFs activate other proteins through phosphorylation. These phosphorylated proteins, in turn, are responsible for specific ... Protein cyclin A governs this process by keeping the process going until the errors are eliminated. In normal cells, persistent ... Cyclins, when bound with the dependent kinases, such as the p34/cdc2/cdk1 protein, form the maturation-promoting factor. ...
Cellular apoptosis susceptibility protein. *E2F. *Maturation promoting factor. *Wee. *Cullin (CUL7). Phases and. checkpoints. ... cyclin-dependent protein serine/threonine kinase activity. Cellular component. • mediator complex. • nucleoplasm. • Cell ... protein kinase activity. • nucleotide binding. • kinase activity. • protein binding. • RNA polymerase II carboxy-terminal ... The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK8 and cyclin C associate ...
... cellular apoptosis susceptibility protein MeSH D12.776.157.530.750.500 - karyopherins MeSH D12.776.157.530.750.500.100 - alpha ... rap1 gtp-binding proteins MeSH D12.776.157.325.515.500 - ras proteins MeSH D12.776.157.325.515.500.300 - oncogene protein p21( ... smad1 protein MeSH D12.776.157.057.170.500.200 - smad2 protein MeSH D12.776.157.057.170.500.300 - smad3 protein MeSH D12.776. ... smad proteins, inhibitory MeSH D12.776.157.057.170.249.600 - smad6 protein MeSH D12.776.157.057.170.249.700 - smad7 protein ...
Cellular apoptosis susceptibility protein. *E2F. *Maturation promoting factor. *Wee. *Cullin (CUL7). Phases and. checkpoints. ... The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene ... cellular response to interleukin-4. • cellular response to phorbol 13-acetate 12-myristate. • cellular response to ionomycin. • ... protein kinase activity. • kinase activity. • protein serine/threonine kinase activity. • cyclin-dependent protein serine/ ...
Cellular apoptosis susceptibility protein. *E2F. *Maturation promoting factor. *Wee. *Cullin (CUL7). المراحل ونقاط التحقق. ... negative regulation of cyclin-dependent protein serine/threonine kinase activity. • G1/S transition of mitotic cell cycle. • ... regulation of cyclin-dependent protein serine/threonine kinase activity. • oligodendrocyte differentiation. • negative ... Venkataramani R, Swaminathan K, Marmorstein R (1998). "Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides ...
细胞凋亡易感蛋白(英语:Cellular apoptosis susceptibility protein) ... CDK抑制因子(英语:Cyclin-dependent kinase inhibitor protein). *INK4a/ARF(p14arf/p16、p15、p18、p19) ... Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. BioEssays. June 1995, 17 (6): 471-80. PMID ...
HIV may increase the level of cellular proteins that prompt Fas-mediated apoptosis. ... for potential death from signaling-related diseases involves either increasing or decreasing the susceptibility of apoptosis in ... Apoptosis in HeLa[b] cells is inhibited by proteins produced by the cell; these inhibitory proteins target retinoblastoma tumor ... These receptors bind to the proteinTRAIL and mediate apoptosis. Apoptosis is known to be one of the primary mechanisms of ...
Cellular apoptosis susceptibility protein. *E2F. *Maturation promoting factor. *Wee. *Cullin (CUL7). Phases and. checkpoints. ... Apoptosis Interest Group (1999). "About apoptosis". Retrieved 2006-12-15.. *↑ ೯.೦ ೯.೧ Thompson, CB (1995). "Apoptosis in the ... "About Apoptosis". Retrieved November 2009. Apoptosis Interest Group, prefered pronunciation of National Institute of Health. ... "Sequential degradation of proteins from the nuclear envelope during apoptosis". Journal of Cell Science. 114 (20): 3643-53. ...
Deleting the GSNOR gene from both yeast and mice increased the cellular levels of GSNO and nitrosylated proteins, and the yeast ... cells showed increased susceptibility to nitrosative stress. Null mice show increased levels of S-nitrosated proteins, ... trans-nitrosylates the active site cysteine of caspase-3 thus inactivating caspase-3 and preventing induction of apoptosis. As ... Through this catabolic process, GSNOR regulates the cellular concentrations of GSNO and plays a central role in regulating the ...
Activated FANCD2 protein co-localizes with BRCA1 (breast cancer susceptibility protein) at ionizing radiation-induced foci and ... The main cellular phenotype is hypersensitivity to DNA damage, particularly inter-strand DNA crosslinks. The FA proteins ... Loss of FANCG causes neural progenitor apoptosis during forebrain development, likely related to defective DNA repair. (Sii- ... Fanconi anemia group G protein is a protein that in humans is encoded by the FANCG gene. FANCG, involved in Fanconi anemia, ...
... leads to premature cellular senescence and therefore inhibition of haemopoietic function. Senescence, together with apoptosis, ... that is detected by the FANCM protein. Following assembly, the protein core complex activates FANCL protein which acts as an E3 ... D'Andrea AD (2010). "Susceptibility pathways in Fanconi's anemia and breast cancer". N. Engl. J. Med. 362 (20): 1909-19. doi: ... Recent studies have shown that eight of these proteins, FANCA, -B, -C, -E, -F, -G, -L and -M, assemble to form a core protein ...
Cellular apoptosis susceptibility protein. *E2F. *Maturation promoting factor. *Wee. *Cullin (CUL7). Phases and. checkpoints. ... protein kinase binding. • nucleotide binding. • GTP binding. • identical protein binding. Cellular component. • cytoplasm. • ... GTP-dependent protein binding. • GTPase activity. • mitogen-activated protein kinase kinase kinase binding. • protein binding. ... "Protein Data Bank in Europe. EMBL-EBI. Retrieved 2016-04-22.. *^ "CDC42 (cell division cycle 42 (GTP binding protein, 25kDa))" ...
HIV may increase the level of cellular proteins that prompt Fas-mediated apoptosis. ... of treatment for death from signaling-related diseases involves either increasing or decreasing the susceptibility of apoptosis ... PROTEINS: Structure, Function, and Genetics 50, 44-48.. *^ Chen Y. L.; Li Q. Z. (2007). "Prediction of apoptosis protein ... Apoptosis in HeLa[b] cells is inhibited by proteins produced by the cell; these inhibitory proteins target retinoblastoma tumor ...
An enhanced susceptibility to pyocyanin is seen in cells with certain mutant proteins or complexes. Mutations in genes ... Additionally, neutrophil apoptosis, immunoglobulin release from B-lymphocytes, and interleukin release (e.g. IL-8 and CCL5) are ... Pyocyanin is able to target a wide range of cellular components and pathways. Pathways that are affected by pyocyanin include ... Secondly, phosphorylation of CFTR by Protein kinase A II should occur in order for the channel to be operational. PKA II is ...
Targeted therapies are designed to affect cellular proteins or processes that are utilised by the cancer cells. This allows a ... Cancer cells can also cause defects in the cellular pathways of apoptosis (programmed cell death). As most chemotherapy drugs ... The susceptibility of an individual to liver damage can be altered by other factors such as the cancer itself, viral hepatitis ... Microtubules are an important cellular structure composed of two proteins, α-tubulin and β-tubulin. They are hollow, rod-shaped ...
Mechanisms of control via regulation of extracellular matrix proteins, cellular surface markers, cellular adhesion molecules, ... Apoptosis, or induced cell suicide, usually serves as a mechanism to prevent excessive cellular growth. Gatekeeper genes ... A third group of genes in which mutations lead to a significant susceptibility to cancer is the class of landscaper genes. ... Cellular senescence, also encoded by a gatekeeper gene, is arrest of the cell cycle in the G1 phase. Qualitative differences ...
The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the ... "Localization of a susceptibility gene for common forms of stroke to 5q12". American Journal of Human Genetics. 70 (3): 593-603 ... Cellular Signalling. 13 (7): 507-13. doi:10.1016/S0898-6568(01)00167-X. PMID 11516626. Michot C, Le Goff C, Goldenberg A, ... "Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia". ...
"Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration". Biochemical and ... it is suggested that susceptibility to FASTKD2-mediated apoptosis requires certain factors to associate with the DIF-1 complex ... FAST kinase domain-containing protein 2 (FASTKD2) is a protein that in humans is encoded by the FASTKD2 gene on chromosome 2. ... plasma membrane breakdown and cellular disintegration. Apoptosis occurs in many physiological and pathological processes. It ...
Examples of caspase cascade during apoptosis:. *Intrinsic apoptopic pathway: During times of cellular stress, mitochondrial ... which is facilitated by binding to adaptor proteins via protein-protein interaction motifs that are collectively referred to as ... Insufficient activation of these caspases can increase an organism's susceptibility to infection, as an appropriate immune ... Apoptosis[edit]. Apoptosis is a form of programmed cell death where the cell undergoes morphological changes, to minimize its ...
Examples of caspase cascade during apoptosis: *Intrinsic apoptopic pathway: During times of cellular stress, mitochondrial ... which is facilitated by binding to adaptor proteins via protein-protein interaction motifs that are collectively referred to as ... Insufficient activation of these caspases can increase an organism's susceptibility to infection, as an appropriate immune ... This leads to degradation of cellular components for apoptosis.. *Extrinsic apoptopic pathway: The caspase cascade is also ...
... susceptibility to leukemia and other cancers, and cellular hypersensitivity to interstrand DNA cross-linking agents. Generally ... Amongst known FANC proteins, most evidence points for a direct interaction primarily between FANCA protein and BRCA1. Evidence ... Also apoptosis is increased in the mutant germ cells. The Fanconi anemia DNA repair pathway appears to play a key role in ... This mechanic is also supported by the protein-protein interactions between BRG1 and both BRCA1 and FANCA, that serve to ...
Here, the single-stranded DNA curls around in a long circle, stabilized by telomere-binding proteins. At the very end of the T- ... The cell may detect this uncapping as DNA damage and then either stop growing, enter cellular old age (senescence), or begin ... Since this damage cannot be repaired in normal somatic cells, the cell may even go into apoptosis. Many aging-related diseases ... However, shortened telomeres impair immune function that might also increase cancer susceptibility. If telomeres become too ...
In addition, INK4 proteins play roles in cellular senescence, apoptosis and DNA repair. INK4 proteins are tumor suppressors and ... p15INK4b/p16INK4a homolog were found to segregate with melanoma susceptibility in the Xiphophorus indicating that INK4 proteins ... The other family of CKIs, CIP/KIP proteins are capable of inhibiting all CDKs. Enforced expression of INK4 proteins can lead to ... INK4 proteins are cell-cycle inhibitors. When they bind to CDK4 and CDK6, they induce an allosteric change that leads to the ...
Accelerated apoptosis occurs in the neutrophils and bone marrow. X-linked SCN (SCNX) is caused by mutation in the WASP gene on ... The GATA2 protein is a transcription factor critical for the embryonic development, maintenance, and functionality of blood- ... These autosomal dominant mutations cause a reduction, i.e. a haploinsufficiency, in the cellular levels of the gene's product, ... Over time, however, the deficiency commonly progresses to include thrombocytopenia, increases susceptibility to infections due ...
This protein is also found to interact with PALB2[10] and BRCA2, which may be important for the cellular response to DNA damage ... The breast cancer susceptibility protein BRCA2 and PALB2 controls the function of Rad51 in the pathway for DNA repair by ... DNA damage-induced oocyte apoptosis depends on the efficiency of the DNA repair machinery that in turn declines with age. ... protein C-terminus binding. • protein binding. • four-way junction DNA binding. • identical protein binding. • ...
Nelson AM, Gilliland KL, Cong Z, Thiboutot DM (October 2006). "13-cis Retinoic acid induces apoptosis and cell cycle arrest in ... Isotretinoin has been speculated to down-regulate the enzyme telomerase and hTERT, inhibiting "cellular immortalization and ... Isotretinoin is primarily (99.9%) bound to plasma proteins, mostly albumin. Three metabolites of Isotretinoin are detectable in ... and an increased susceptibility to sunburn. Uncommon and rare side effects include muscle aches and pains (myalgias), and ...
Protein khas CNS seperti pancortin-2 akan berinteraksi dengan protein modulator aktin, Wiskott-Aldrich syndrome protein ... "Cellular and molecular mechanisms of neural repair after stroke: making waves". Department of Neurology, David Geffen School of ... Di area penumbra, apoptosis neural akan berusaha dihambat oleh kedua mekanisme eksitotoksik dan peradangan,[20] oleh karena sel ... "Silent cerebral microbleeds on susceptibility-weighted imaging of patients with ischemic stroke and leukoaraiosis". Department ...
mitogen-activated protein kinase kinase kinase binding. Cellular component. • cytoplasm. • cell body. • cytosol. • dendritic ... induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose ... This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 ... protein kinase inhibitor activity. • protein binding. • kinesin binding. • protein kinase binding. • JUN kinase binding. • ...
T cells that attack the body's own proteins are eliminated in the thymus. Thymic epithelial cells express major proteins from ... Involution of the thymus has been linked to loss of immune function in the elderly, susceptibility to infection and to cancer. ... but the neck of the flask persists for some time as a cellular cord. By further proliferation of the cells lining the flask, ... whereby T cells with high affinity interaction are eliminated through apoptosis (to avoid autoimmunity), and those with ...
ALOX5 binds with the F actin-binding protein, coactin-like protein. Based on in vitro studies, this protein binding serves to ... Cellular component. • cytoplasm. • cytosol. • nuclear membrane. • membrane. • nuclear matrix. • nuclear envelope lumen. • cell ... These studies suggest genetic variants may play a role, albeit a relatively minor one, in the overall susceptibility to ... and the pharmacological inhibition of ALOX5 in these human cell lines causes them to die by entering apoptosis.[18][19][20][21] ...
Induction of autoantibodies against tyrosinase-related proteins following DNA vaccination: Unexpected reactivity to a protein ... Dendritic cell apoptosis - immune system cells called dendritic cells present antigens to active lymphocytes. Dendritic cells ... This susceptibility is associated with multiple genes plus other risk factors. Genetically predisposed individuals do not ... All that is required is that a B cell recognising antigen X endocytoses and processes a protein Y (normally =X) and presents it ...
Microtubules are an important cellular structure composed of two proteins; α-tubulin and β-tubulin. They are hollow rod shaped ... Cancer cells can also cause defects in the cellular pathways of apoptosis (programmed cell death). As most chemotherapy drugs ... The susceptibility of an individual to liver damage can be altered by other factors such as the cancer itself, viral hepatitis ... Targeted therapies are designed to affect cellular proteins or processes that are utilised by the cancer cells. This allows a ...
Recombinant activated protein C (drotrecogin alpha) was originally introduced for severe sepsis (as identified by a high APACHE ... Neutrophils, monocytes, macrophages, dendritic cells, CD4+ T cells, and B cells all undergo apoptosis, whereas regulatory T ... January 1980). "Genetic control of susceptibility to Salmonella typhimurium in mice: Role of the LPS gene". Journal of ... Heart: systolic and diastolic heart failure, likely due to chemical signals that depress myocyte function, cellular damage, ...
Jönsson TJ, Lowther WT (2007). The peroxiredoxin repair proteins. Sub-Cellular Biochemistry. Subcellular Biochemistry. 44. pp. ... show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide". The Journal of ... protection against oxidant toxicity and regulation of stress-mediated apoptosis". Antioxidants & Redox Signaling. 6 (2): 289- ... The thioredoxin system contains the 12-kDa protein thioredoxin and its companion thioredoxin reductase.[149] Proteins related ...
Cellular adaptation. Atrophy. Hypertrophy. Hyperplasia. Dysplasia. Metaplasia Squamous. Glandular. Cell death. Necrosis ... The ability of the viral protein hemagglutinin to bind red blood cells together into a detectable matrix may also be ... Those with compromised or weakened immune systems have an increased susceptibility to chronic or persistent infections. ... Apoptosis. Pyknosis. Karyorrhexis. Karyolysis. Accumulations. pigment Hemosiderin. Lipochrome/Lipofuscin. Melanin. Steatosis. ...
Examples of caspase cascade during apoptosis: *Intrinsic apoptopic pathway: During times of cellular stress, mitochondrial ... which is facilitated by binding to adaptor proteins via protein-protein interaction motifs that are collectively referred to as ... Insufficient activation of these caspases can increase an organism's susceptibility to infection, as an appropriate immune ... This leads to degradation of cellular components for apoptosis.. *Extrinsic apoptopic pathway: The caspase cascade is also ...
in Apoptosis miR-181d is disregulated in Duchenne Muscular Dystrophy (DMD). miR-181d is disregulated in nemaline myopathy (NM ... miR-181 expression has a reverse correlation with Tcl1 protein expression. mir-181 a and b are over-expressed and act as bad ... The increased expression of miR-181a in mature T cells increases susceptibility to peptide antigens, while inhibiting the ... annotation and profiling of microRNAs as targets for cellular engineering". Journal of Biotechnology. 153 (1-2): 62-75. doi: ...
MHC class II protein binding. Cellular component. • membrane. • external side of plasma membrane. • integral component of ... Scientists working with AstraZeneca reported in March 2005 that SNPs on LAG3 conferred susceptibility to multiple sclerosis[48] ... showed that the binding of MHC class II molecules on melanoma cells to LAG3 would increase resistance to apoptosis, providing ... Protein[edit]. The LAG3 protein, which belongs to immunoglobulin (Ig) superfamily, comprises a 503-amino acid type I ...
Renal disorder: More than 0.5 g per day protein in urine or cellular casts seen in urine under a microscope; sensitivity = 51 ... express CD68 protein. These cells normally engulf B cells that have undergone apoptosis after somatic hypermutation. In some ... SLE is presumably caused by a genetic susceptibility coupled with an environmental trigger which results in defects in the ... Each protein is a link on the autoimmune chain, and researchers are trying to find drugs to break each of those links.[10][56][ ...
... which produces the APC protein. The APC protein prevents the accumulation of β-catenin protein. Without APC, β-catenin ... The microscopic cellular characteristics of the tumor are reported from the analysis of tissue taken from a biopsy or surgery. ... Certain markers isolated from the tumor can indicate specific cancer types or susceptibility to different treatments.[71] ... Srikumar Chakravarthi; Baba Krishnan; Malathy Madhavan (1999). "Apoptosis and expression of p53 in colorectal neoplasms". ...
NDV triggers apoptosis[17] in a wide range of cancer cell types via the mitochondrial/intrinsic pathway, through loss of ... A study[15] demonstrated the engineered Hitcher B1 NDV/F3aa strain could be modified to express a highly fusogenic F-protein in ... Its effects are most notable in domestic poultry due to their high susceptibility and the potential for severe impacts of an ... by suppressing the induction of the cellular interferons.[16] ... apoptosis-inducing ligand-induced, NDV-mediated apoptosis in a ...
2007). «ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study.». Lancet ... induced apoptosis of human T-lymphoma cells.». Cell Calcium. 27 (6): 315-28. PMID 11013462. doi:10.1054/ceca.2000.0126. ... 5-trisphosphate receptors can occur as integral plasma membrane proteins.». J. Biol. Chem. 275 (35): 27488-93. PMID 10874040. ... cellular response to cAMP. •cellular response to ethanol. Sources: Amigo / QuickGO. Ortólogos. ...
Cytolytic granule mediated cell apoptosis[edit]. NK cells are cytotoxic; small granules in their cytoplasm contain proteins ... Cellular and Molecular Immunology by Abbul K. Abbas & Andrew Lichtman Saunders Copyright 2003 ... a firm conclusion has not yet been drawn as to what combination provides decreased HIV and AIDS susceptibility. ... inducing either apoptosis or osmotic cell lysis. The distinction between apoptosis and cell lysis is important in immunology: ...
Mahley RW, Rall SC (2002). "Apolipoprotein E: far more than a lipid transport protein". Annual Review of Genomics and Human ... Jiang L, Zhong J, Dou X, Cheng C, Huang Z, Sun X (Aug 2015). "Effects of ApoE on intracellular calcium levels and apoptosis of ... Huang Y, Weisgraber KH, Mucke L, Mahley RW (2004). "Apolipoprotein E: diversity of cellular origins, structural and biophysical ... "Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis". ...
Bosman GJ, Willekens FL, Werre JM (2005). "Erythrocyte aging: a more than superficial resemblance to apoptosis?". Cellular ... Any limitations of glycolysis can result in more susceptibility to oxidative damage and a short or abnormal lifecycle. If the ... a protein that binds free hemoglobin. Examination of a peripheral blood smear and some other laboratory studies can contribute ... February 1998). "Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review". Biochimie. ...
Mature Th cells express the surface protein CD4 and are referred to as CD4+ T cells. Such CD4+ T cells are generally treated as ... Cellular immune system. Maximizes the killing efficacy of the macrophages and the proliferation of cytotoxic CD8+ T cells. Also ... These cells are generally believed to circulate throughout the body with no value until they undergo apoptosis. ... TH2 and TH-17 effector cells selectively regulates susceptibility to cell death". Nat Immunol. 8 (8): 825-34. doi:10.1038/ ...
It affects the production of multiple proteins, including lipoproteins, binding proteins, and proteins responsible for blood ... "Molecular and Cellular Endocrinology. 389 (1-2): 71-83. doi:10.1016/j.mce.2014.02.002. PMC 4040308. PMID 24530924.. ... to prevent apoptosis of male sperm cells.[15] While some studies in the early 1990s claimed a connection between globally ... Magnetic susceptibility (χ). -186.6·10−6 cm3/mol Pharmacology ATC code ...
"Cas Proteins". www.sinobiological.com. Retrieved 2019-12-04. Cellular+Apoptosis+Susceptibility+Protein at the US National ... The Cas family of proteins are a family of proteins that induce cellular apoptosis and cell proliferation. Apoptosis is a ... The cellular apoptosis susceptibility protein (CAS) is an exportin which in the nucleus is bound to RanGTP. ... ALong with this correlation, in the absence of the CAS protein in a cell, there is an inhibition of apoptosis Along with being ...
A nucleocytoplasmic transport protein that binds to ALPHA KARYOPHERINS and RAN GTP BINDING PROTEIN inside the CELL NUCLEUS and ... It is also associated with the regulation of APOPTOSIS and microtubule assembly. ... Cellular Apoptosis Susceptibility Protein. Subscribe to New Research on Cellular Apoptosis Susceptibility Protein ... Carrier Proteins: 11456*Membrane Transport Proteins: 165*Nucleocytoplasmic Transport Proteins*Cellular Apoptosis Susceptibility ...
... Description: Cellular ... apoptosis susceptibility protein, the product of the CAS gene, is associated with microtubules and the mitotic spindle. CAS is ... proliferation and apoptosis is not yet fully understood. High expression of cytoplasmic CAS protein appears to correlate with ... CAS expression may be useful in the identification of proliferating cells and in the elucidation of the function of cellular ...
The cellular apoptosis susceptibility (CSE1L/CAS) protein has been shown to regulate MMP-2 secretion.. METHODS: We examined if ... Tung A, Tsao A, Chen H, Tai H, Shen H, Cheng A, Jiang I, Presence of secretory cellular apoptosis susceptibility protein in ... Presence of secretory cellular apoptosis susceptibility protein in cerebrospinal fluids of patients with intracerebral ... Cellular Apoptosis Susceptibility Protein:cerebrospinal fluid, Cerebral Hemorrhage:cerebrospinal fluid, Humans, Interferon- ...
Cellular Apoptosis Susceptibility Protein Clone 30F12 \ MC-128 for more molecular products just contact us ... Cellular Apoptosis Susceptibility Protein Clone 30F12. Related products : Cellular Apoptosis Susceptibility Protein Clone 30F12 ... Cellular Apoptosis Susceptibility Protein Clone 30F12 / Product Detail : MC-128 Cellular Apoptosis Susceptibility Protein Clone ... Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) ( ...
Overexpression of Sxm1p, a protein related to Cse1p in yeast and to the human cellular apoptosis susceptibility protein, ... to human cellular apoptosis susceptibility protein (CAS) (44), and 14.5% to Lph2p. The phylogenetic relationship between these ... four yeast Cse1p-like proteins and a human homolog, the cellular apoptosis susceptibility protein, is shown in Fig. 4C. ... green fluorescent protein;. SV40,. simian virus 40;. hnRNP,. heterogeneous nuclear ribonucleoprotein;. CAS,. cellular apoptosis ...
The present invention also relates to a method for the preparation of said protein. This chimeric protein is prepared by ... The said chimeric protein is comprised of a cell targeting moiety for FcεRI expressing cells and a cell killing moiety. The ... The chimeric protein, produced in E. coli, specifically and efficiently kills mouse mast cell lines expressing the FcεRI ... The present invention provides a chimeric protein for targeted elimination of FcεRI expressing cells especially useful for the ...
Rabbit recombinant monoclonal Cellular Apoptosis Susceptibility/CSE1L antibody [EPR10326(B)]. Validated in WB and tested in ... Cellular and biochemical assays. By product type. Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists ... Anti-Cellular Apoptosis Susceptibility/CSE1L antibody [EPR10326(B)]. See all Cellular Apoptosis Susceptibility/CSE1L primary ... All lanes : Anti-Cellular Apoptosis Susceptibility/CSE1L antibody [EPR10326(B)] (ab150432) at 1/1000 dilution. Lane 1 : HeLa ...
We now show that Npap60 (also called Nup50), a protein previously believed to be a structural component of the NPC, is a Ran ... Many nuclear-targeted proteins are transported through the nuclear pore complex (NPC) by the importin-alpha:beta receptor. ... binding protein and a cofactor for importin-alpha:be … ... Cellular Apoptosis Susceptibility Protein / genetics * Cellular ... Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import Cell. 2002 Aug 9;110(3 ...
cellular apoptosis susceptibility protein. chromosome segregation 1-like protein. epididymis secretory sperm binding protein. ... Title: The Cellular Apoptosis Susceptibility Protein (CAS) Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand ( ... Expression of CAS/CSE1L, the Cellular Apoptosis Susceptibility Protein, Correlates With Neoplastic Progression in Barretts ... Title: Expression of CAS/CSE1L, the Cellular Apoptosis Susceptibility Protein, Correlates With Neoplastic Progression in ...
Tung J, Tsao T, Chen S, Tai C, Shen S, Cheng Y, Jiang M. Presence of secretory cellular apoptosis susceptibility protein in ... Presence of secretory cellular apoptosis susceptibility protein in cerebrospinal fluids of patients with intracerebral ... Cellular Apoptosis Susceptibility Protein:cerebrospinal fluid, Cerebral Hemorrhage:cerebrospinal fluid, Humans, Interferon- ... OBJECTIVE: Protein Isl-1 RNA interference and over expression in early chicken embryo dorsal root ganglia (DRG) were used to ...
Serum cellular apoptosis susceptibility protein is a potential prognostic marker for metastatic colorectal cancer. Am J Pathol ... Protein lysine acetylation in cellular function and its role in cancer manifestation. Biochim Biophys Acta 2010;1799:702-16. ... Ecto-protein kinase substrate p120 revealed as the cell-surface-expressed nucleolar phosphoprotein Nopp140: a candidate protein ... For some of nuclear proteins, there is a nuclear export system in which the factor CRM1 recognizes a special protein sequence ...
... cellular apoptosis susceptibility protein). ... The proapoptotic proteins Bax and Bak also mediate T cell ... Clusters of about 75 molecules of the membrane protein syntaxin result from weak attraction among the proteins balanced by ... Optineurin and NEMO both bind to proteins with lysine 63-linked polyubiquitin chains, but have opposing effects on NF-κB ... Structure and Function of the PB1 Domain, a Protein Interaction Module Conserved in Animals, Fungi, Amoebas, and Plants ...
The cellular apoptosis susceptibility protein (CAS) promotes TRAIL-induced apoptosis and cell proliferation: P. Monian & X. ... Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins ... An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells: H. Zhu, et al ... TRAIL-induces apoptosis but not necroptosis in colorectal and pancreatic cancer cells preferentially via the TRAIL-R2/DR5 ...
Several other proteins such as RAN GTP BINDING PROTEIN and CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN bind to karyopherins and ... Protein Transport. The process of moving proteins from one cellular compartment (including extracellular) to another by various ... Vesicular Transport Proteins. A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT ... Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the ...
Protein Aliases: Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; CSE1; CSE1 chromosome ... CAS (cellular apoptosis susceptibility contains 971 amino acids with 59% overall sequence homology as compared to yeast ... protein import into nucleus protein export from nucleus apoptotic process cell proliferation ...
... of a gene encoding a protein with a high degree of similarity to the mammalian protein cellular apoptosis susceptibility factor ... 2000 Serine/threonine protein kinases and apoptosis. Exp. Cell Res. 256: 34-41. ... 1998 Apoptosis of nurse cells at the late stages of oogenesis of Drosophila melanogaster. Dev. Genes Evol. 208: 106-112. ... The predicted protein encoded by this gene was related to human ACAT1 and ACAT2 more closely than to human DGAT (Figure 3C). ...
Abbreviations used in this paper: CAS, cellular apoptosis susceptibility; GAP, GTPase activating protein; GEF, guanine ... cellular apoptosis susceptibility) protein carrier (Kutay et al., 1997a). CAS requires bound RanGTP to bind Kap-α with high ... Contributing to the rapid loss of free GTP upon ATP depletion is probably the presence of many cellular ATP-using proteins that ... The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature. ...
CAS (cellular apoptosis susceptibility protein) is part of the importin-β superfamily of karyopherins and is defined as a ... but the key proteins involved had not been elucidated up until that point. A 60 kDa cytosolic protein, essential for protein ... Many different cargo proteins can be transported into the nucleus by importin. Often, different proteins will require different ... breast cancer type 1 susceptibility protein), into the nucleus. The overexpression of importin-α has also been linked with poor ...
... the Cellular Apoptosis Susceptibility Protein, Correlates With Neoplastic Progression in Barretts Esophagus. Appl ... Jiang K, Tan E, Sayegh Z, Centeno B, Malafa M, Coppola D. Cancer Antigen 125 (CA125, MUC16) Protein Expression in the Diagnosis ... Johnson DR, Abdelbaqui M, Tahmasbi M, Mayer Z, Lee HW, Malafa MP, Coppola D. CDX2 protein expression compared to alcian blue ... EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells. J Nutr Biochem. 2015 ...
... the Cellular Apoptosis Susceptibility Protein, Correlates With Neoplastic Progression in Barretts Esophagus. Appl ... Laminar shear stress stimulates vascular smooth muscle cell apoptosis via the Akt pathway. J Cell Physiol. 2008 Aug.216(2):389- ...
The phosphorylation of MEK and ERK proteins was inhibited by ChPL in breast cancer cells and ChPL-induced apoptosis increased ... ChPL inhibited the phosphorylation of MEK and ERK proteins in breast cancer cells, and increased apoptosis induction in cells ... The induction of apoptosis by ChPL was found to be mediated through MAP kinase signaling inhibition. ... The induction of apoptosis by ChPL was found to be mediated through MAP kinase signaling inhibition. ...
... cellular apoptosis susceptibility protein的用法,cellular apoptosis susceptibility protein翻 ... 专业出版cellular apoptosis susceptibility protein是什么意思, ...
... cellular apoptosis susceptibility protein).. Cell Polarity.. ZBP-1 and staufen expression in MTLn3 cells was much lower ... MTC cells and tumors express more programmed cell death and cellular apoptosis susceptibility proteins such as Pdcd and Casp ( ... IGF-binding protein 5 (IGFBP5), mitogen-activated protein kinase 7, lymphoid enhancer factor 1 (Lef1), G protein-coupled ... and protein concentrations were measured by bicinchoninic acid protein assay (Bio-Rad). Equal amounts of proteins were resolved ...
PEIRO ET AL.: "CAS (Cellular Apoptosis Susceptibility) Gene Expression in Ovarian Carcinoma: Correlation With 20q13.2 Copy ... Chromosomal probes may be prepared, for example, from protein nucleic acids, cloned human DNA such as plasmids, bacterial ... Number and Cyclin D1, p53, and Rb Protein Expression.", AM J CLIN PATHOL., vol. 118, no. 6, 2002, pages 922 - 929. ...
Cellular Apoptosis Susceptibility Protein Catenins Brain Caspase 9 In this issue. Kopper, L., 2007, In : Pathology and Oncology ... Collagen XVII/BP180 protein expression in squamous cell carcinoma of the skin detected with novel monoclonal antibodies in ... Expression of mTORC1/2-related proteins in primary and brain metastatic lung adenocarcinoma. Krencz, I., Sebestyén, A., Fábián ... Notch-regulation upon Dll4-stimulation of TGFb-induced apoptosis and gene expression in human B-cell non-hodgkin lymphomas. ...
Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis.J. Immunol. 162 1999 5205 5211 ... A human cellular homolog of v-FLIPs was found and termed cellular FLICE-inhibitory protein (c-FLIP; also called FLAME-1, I- ... Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE- ... FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis. Andreas Krueger, Sven Baumann, Peter H. Krammer, ...
Herein, we report that cellular apoptosis susceptibility (CAS) (or CSE1L) protein regulates the secretion of HT-29 human ... Herein, we report that cellular apoptosis susceptibility (CAS) (or CSE1L) protein regulates the secretion of HT-29 human ... Herein, we report that cellular apoptosis susceptibility (CAS) (or CSE1L) protein regulates the secretion of HT-29 human ... Herein, we report that cellular apoptosis susceptibility (CAS) (or CSE1L) protein regulates the secretion of HT-29 human ...
CAS (cellular apoptosis susceptibility) gene expression in ovarian carcinoma: Correlation with 20q13.2 copy number and cyclin ... SeOvCa protein interactions. We scanned the Human Protein Atlas (HPR, 38) for SeOvCa protein expression and identified positive ... Protein Interaction Network Analysis (PINA) was used to predict PPIs. PINA represents an integrated platform for protein ... Integrated network analysis platform for protein-protein interactions. Nat Methods 2009;6:75-7. ...
Altogether, these results reveal that the absence of the cellular prion protein impairs copper metabolism and copper-dependent ... In prion protein-null mouse total brain and hippocampus, metal ion content shows a fluctuating trend, suggesting the presence ... In prion protein-null mouse total brain and hippocampus, metal ion content shows a fluctuating trend, suggesting the presence ... Prion protein, for instance, interacts with divalent cations via multiple metal-binding sites and it modulates several metal- ...
  • The cellular apoptosis susceptibility (CSE1L/CAS) protein has been shown to regulate MMP-2 secretion. (nel.edu)
  • Synthetic peptide within Human Cellular Apoptosis Susceptibility/CSE1L aa 1-100 (N terminal). (abcam.com)
  • Expression of CAS/CSE1L, the Cellular Apoptosis Susceptibility Protein, Correlates With Neoplastic Progression in Barrett's Esophagus. (nih.gov)
  • Herein, we report that cellular apoptosis susceptibility (CAS) (or CSE1L) protein regulates the secretion of HT-29 human colorectal cells. (elsevier.com)
  • 2003). The CSE1L/CAS protein is a Ran-binding protein which acts as nuclear transport (export) factor, and simultaneously plays a role in the mitotic spindle checkpoint, which assures genomic stability during cell division. (scielo.org.ar)
  • The Cas family of proteins are a family of proteins that induce cellular apoptosis and cell proliferation. (wikipedia.org)
  • Cas is a 2 terminal protein, a N-terminal and a C-terminal, and there is a positive correlation between the presence of CAS and the degree of cellular proliferation. (wikipedia.org)
  • The molecular mechanism or function by which CAS is associated with cell proliferation and apoptosis is not yet fully understood. (ihcworld.com)
  • High expression of cytoplasmic CAS protein appears to correlate with proliferation of lymphoid cells. (ihcworld.com)
  • In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. (nih.gov)
  • The proapoptotic proteins Bax and Bak also mediate T cell proliferation. (sciencemag.org)
  • The results showed that ChPL inhibited breast cancer cell proliferation and induced apoptosis through the intrinsic pathway through down-regulation of anti-apoptotic Bcl-2 family proteins. (frontiersin.org)
  • CAS might have a key role in the apoptosis induced by toxins, acting as anti-apoptotic factor, stimulating the cellular proliferation and the cell contact stabilization. (bvsalud.org)
  • These results suggest a dual role of CAS in the cellular cycle control during the CY-induced apoptosis: induction of cell proliferation and stabilization of the cell-cell junctions by modulating CAMs expression. (bvsalud.org)
  • Cellular apoptosis susceptibility protein and proliferation in human hepatocellular carcinoma. (termsreign.cf)
  • IREB2 is a gene that produces iron regulatory protein 2 (IRP2), which is critical to intracellular iron homeostasis and which relates to the rate of cellular proliferation. (ersjournals.com)
  • and proliferation, apoptosis and migration were assessed. (ersjournals.com)
  • Surprisingly, imatinib inhibited cell proliferation and TRAIL-mediated apoptosis in melanoma cells. (nih.gov)
  • We now show that a synthetic analogue of noscapine, 9-bromonoscapine, is ∼10-fold to 15-fold more potent than noscapine in inhibiting cell proliferation and induces apoptosis following G 2 -M arrest in hormone-insensitive human breast cancers (MDA-MB-231). (aacrjournals.org)
  • During postlactational regression of breasts, extensive apoptosis of ductal cells is required, whereas myoepithelial cells and basal lamina persist, and are reused during the resumption of extensive cell proliferation ( 5 , 6 ). (aacrjournals.org)
  • 2001). CAS is also implicated in the nuclear to cytoplasmic reshuffling of importin alpha, which itself is necessary for the nuclear transport of several proliferation activating proteins, transcription factors, oncogene and tumor suppressor gene products such as p53 and BRCA1 (Behrens et al . (scielo.org.ar)
  • 2003). Furthermore, CAS may have a dual function in mammalian cells, one in cell proliferation and another in apoptosis (Brinkmann et al . (scielo.org.ar)
  • The CAS proteins (p130 CAS , HEF1/CAS-L and Efs/Sin), a family of docking proteins, are important components of integrin receptor signaling and have been implicated in cell-matrix adhesion, cellular migration, proliferation, transformation and apoptosis (O'Neill et al . (scielo.org.ar)
  • HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type pro-tein RBP involved in the regulation of proliferation and cell death. (handmade4u.ro)
  • Cellular apoptosis susceptibility protein, the product of the CAS gene, is associated with microtubules and the mitotic spindle. (ihcworld.com)
  • The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. (nih.gov)
  • Two new players in the game controlling p53 target gene promoter choice are Hzf and CAS (cellular apoptosis susceptibility protein). (sciencemag.org)
  • The midway gene encodes a protein similar to mammalian acyl coenzyme A: diacylglycerol acyltransferase (DGAT), which converts diacylglycerol (DAG) into triacylglycerol (TAG). (genetics.org)
  • The discovery of specific genes that correlate with metastatic potential cannot be related to mechanism unless the metastatic step at the cellular level in which the gene is involved is identified. (aacrjournals.org)
  • Ideally, high-resolution methods for the analysis of metastasis at the cellular level, such as imaging of cells within tumors, when combined with array-based approaches, could be used to accurately evaluate the roles of specific gene products in the individual steps of metastasis. (aacrjournals.org)
  • More importantly, the predicted network-based interactions and known functionality of the identified gene set provide novel insights toward a mechanistic understanding of cellular transformation processes. (aacrjournals.org)
  • The protein encoded by the CCT6A gene is a molecular chaperone, which is a member of the chaperone containing the TCP1 complex (CCT). (researchsquare.com)
  • Cell division protein kinase 7 is an enzyme that in humans is encoded by the CDK7 gene . (wikidoc.org)
  • The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. (wikidoc.org)
  • The protein encoded by this gene is a DNA-binding leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. (bio-rad.com)
  • The nuclear bodies contain, in addition to PML (in normal individuals), several important regulatory proteins including SUMO-1 (see next page), CREB-binding protein, retinoblastoma-susceptibility gene product (pRB), the death-domain-associated protein (Daxx), and p53. (thefreelibrary.com)
  • V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog ( MAF ) is a gene that encodes a protein that, depending on the binding site and binding partner, functions as a transcriptional activator or repressor. (mycancergenome.org)
  • Cell susceptibility to TRAIL-mediated apoptosis was found to be correlated with gene expression signatures in this model. (nih.gov)
  • The prognostic and predictive values of parameters such as microsatellite instability, angiogenesis, Maspin gene/protein, K-ras and BRAF mutations are discussed in relationship to the classical antibodies such as Keratin 7/20, p53 or HER2. (rjme.ro)
  • Since their addition to the BCERP in 2009, the investigators for the Windows of Susceptibility (WOS) studies have been pursuing novel experimental and ancillary epidemiological, clinical, or population studies involving human subjects focusing on the gene-environment interactions as well as molecular mechanisms of environmental influences on breast cancer risk operational during relevant windows of susceptibility over the life span of an organism. (bcerp.org)
  • Overexpression of A20 by means of adenovirus-mediated gene transfer protects islets from IL-1β and interferon γ-induced apoptosis. (rupress.org)
  • Isolated, purified, and recombinant nucleic acids and proteins corresponding to the human GC6 gene and its mRNA and protein products, as well as peptides and antibodies corresponding to the GC6 protein can be used to identify. (google.es)
  • The present invention relates to cellular senescence, markers of cellular senescence, and methods and reagents for identifying senescent cells and agents that alter senescent gene expression expression of cells, as well as for detecting, diagnosing, preventing, and treating senescence-related diseases and conditions in humans and other mammals. (google.es)
  • The invention provides oligonucleotide probes and primers, polynucleotide plasmids or vectors, peptides, proteins, and antibodies relating to genes and gene products associated with the senescence in mammalian cells. (google.es)
  • HSV-1 modulation of apoptosis is tied to its stepwise pattern of viral gene regulation. (dmu.edu)
  • The CAS (cellular apoptosis susceptibility) gene is the human homolog of the yeast chromosome segregation gene CSE1 (Brinkmann et al . (scielo.org.ar)
  • The results of this research indicate that ChPL induces apoptosis in breast cancer cells through MAPK-mediated Mcl-1 inhibition, suggesting further research into its potential in breast cancer treatment. (frontiersin.org)
  • Cellular stress induces p53‐dependent responses. (embopress.org)
  • p73 induces apoptosis by different mechanisms. (wikiwand.com)
  • It has also been reported that ATRA induces a specific degradation of PML-RAR [alpha] protein possibly through a proteasome pathway. (thefreelibrary.com)
  • CAS expression may be useful in the identification of proliferating cells and in the elucidation of the function of cellular apoptosis. (ihcworld.com)
  • Overexpression of Sxm1p, a protein related to Cse1p in yeast and to the human cellular apoptosis susceptibility protein, relieves the defects of cells lacking Pse1p and Kap123p. (pnas.org)
  • The chimeric protein, produced in E. coli , specifically and efficiently kills mouse mast cell lines expressing the FcεRI receptor, as well as primary mast cells derived from bone marrow. (google.com)
  • The present invention provides a chimeric protein for targeted elimination of FcεRI expressing cells especially useful for the therapy of allergic responses. (google.com)
  • The said chimeric protein is comprised of a cell targeting moiety for FcεRI expressing cells and a cell killing moiety. (google.com)
  • 1. A chimeric protein comprising the amino acid sequence of SEQ ID NO: 2 for therapy of allergic responses by targeted elimination of FCεRI expressing cells. (google.com)
  • More specifically the present invention relates to Fcε-PE chimeric protein for targeted elimination of FcεRI expressing cells, a method for its production, and pharmaceutical compositions containing the same. (google.com)
  • This chimeric protein is composed of cell targeting which is a part of IgE molecule linked to cell killing moieties for recognizing and distroying cells overexpressing the specific receptor. (google.com)
  • We found that N-acetyltransferase 10 (NAT10), which is a nucleolar protein, undergoes subcellular redistribution from the nucleolus in normal tissues to the cytoplasm and membrane in colorectal carcinoma cells. (aacrjournals.org)
  • In addition, final cytoplasm transport from nurse cells to the oocyte depends upon apoptosis of the nurse cells. (genetics.org)
  • ChPL inhibited the phosphorylation of MEK and ERK proteins in breast cancer cells, and increased apoptosis induction in cells with reduced ERK expression. (frontiersin.org)
  • We have developed animal models of breast cancer that allow the direct examination of the behavior of individual green fluorescent protein-expressing carcinoma cells in live nonmetastatic and metastatic primary tumors in situ . (aacrjournals.org)
  • By analyzing ~ 1700 proteins using quantitative mass spectrometry in HCC cells we found that CAS depletion by RNA i leads to de-regulation of integrins, particularly down-regulation of integrin β1. (oncotarget.com)
  • identified a protein p21 (WAF1) which was present in cells expressing wild type p53 but not those with mutant p53, moreover constitutive expression of p21 led to cell cycle arrest in a number of cell types. (wikipedia.org)
  • [1] In general, mitosis (division of the nucleus) is preceded by the S stage of interphase (during which the DNA is replicated) and is often accompanied or followed by cytokinesis , which divides the cytoplasm , organelles and cell membrane into two new cells containing roughly equal shares of these cellular components. (wikipedia.org)
  • Gaining a clear understanding of the mechanisms controlling cell fate determination by p53 could lead to the identification of molecular targets for therapy, which could selectively sensitize cancer cells to apoptosis. (embopress.org)
  • This analysis was stimulated by the observation that 293 cells stain strongly and specifically with antibodies to several neurofilament proteins, which are generally thought of as excellent markers for neuronal lineage cells. (novoprolabs.com)
  • A dysfunctional apoptotic system can lead to either excessive removal or prolonged survival of cells and thus dysregulated apoptosis is implicated in pathogenesis of a variety of diseases including oral pathologies. (hindawi.com)
  • The present study investigate the mechanisms by which O2(-) radical mediates signals from Ras protein to the nucleus, leading to cellular responses such as apoptosis in Cr(VI)-stimulated cells. (cdc.gov)
  • Compared to Ras(-) cells, Ras(+) cells exhibited higher susceptibility to apoptosis induced by Cr(VI). (cdc.gov)
  • Results shown above support the following conclusions: (a) Ras protein mediates O2(-) radical generation through reduction of molecular oxygen by NADPH oxidase in Cr(VI)-stimulated cells. (cdc.gov)
  • Arsenic trioxide seems to induce apoptosis in APL cells [4]. (thefreelibrary.com)
  • In order to define genetic determinants of primary and metastatic melanoma cell susceptibility to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), we have applied oligonucleotide microarrays to TRAIL-sensitive primary T1 cells and TRAIL-resistant metastatic G1 cells treated or not with TRAIL. (nih.gov)
  • Moreover, c-FLIP(L) knockdown sensitized T1 cells to TRAIL-mediated apoptosis, with a sensitivity similar to that of cells previously treated with imatinib. (nih.gov)
  • The division of a bacterial cell into two daughter cells is accomplished by a protein called FtsZ. (allisonoutside.com)
  • In this study, the antitumor effects of terpinen-4-ol and the cellular and molecular mechanisms responsible for it were evaluated and studied, respectively on human nonsmall cell lung cancer (NSCLC) cells. (hindawi.com)
  • Diminution of p53 by RNA interference induced necrosis instead of apoptosis in A549 cells following terpinen-4-ol treatment, indicating that terpinen-4-ol-elicited apoptosis is p53-dependent. (hindawi.com)
  • Collectively, these data provide insight into the molecular mechanisms underlying terpinen-4-ol-induced apoptosis in NSCLC cells, rendering this compound a potential anticancer drug for NSCLC. (hindawi.com)
  • Recent reports have indicated that terpinen-4-ol exerts its antitumor effects by triggering caspase-dependent apoptosis in human melanoma cells or by inducing necrotic cell death and cell-cycle arrest in mouse mesothelioma and melanoma cell lines without affecting normal cells [ 14 , 15 ]. (hindawi.com)
  • converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis. (anaspec.com)
  • PTEN dephosphorylates PIP3, yielding PI(4,5)P2, thus PI3K activity (for example, in response to receptor protein tyrosine kinase activation) in Pten-deficient cells results in higher and more sustained levels of PIP3. (monossabios.com)
  • Cytokine-mediated β cell apoptosis requires the active participation of the β cells. (rupress.org)
  • One way to achieve successful islet transplantation for the treatment of IDDM would be to genetically engineer β cells to express antiapoptotic and antiinflammatory proteins ( 24 ). (rupress.org)
  • The zinc finger protein A20 represents one such candidate for genetic engineering of β cells. (rupress.org)
  • Taken together, these data point to a mitochondrially mediated apoptosis of hormone-insensitive breast cancer cells. (aacrjournals.org)
  • One fundamental cause of cellular senescence is the progressive loss of telomeric DNA in somatic cells that lack the enzyme, telomerase (Nakamura et al. (google.es)
  • Instead, IFITM3 promoted antiviral cellular immunity through the restriction of virus-induced lymphopenia, apoptosis-independent NK cell death, and loss of T cells. (jci.org)
  • F ) WT and Ifitm3 -/- FLT3L-, GM-CSF- and M-CSF-generated myeloid cells and primary MEFs were infected with MCMV (MOI = 1), and IL-6 protein was measured 6 hours later. (jci.org)
  • In the present report, we generated clones of FL5.12 lymphoid cells with similar levels of Bcl-2 and Bcl-XL using the Flag epitope to determine if these survival proteins could provide equivalent protection when challenged with chemotherapy or γ-irradiation. (bloodjournal.org)
  • In the present studies, we transfected FL5.12 lymphoid cells with expression constructs that produce Flag-epitope tagged Bcl-2 and Bcl-XL and developed cell clones that express similar levels of these proteins as determined with a Flag-specific antibody. (bloodjournal.org)
  • A common cellular defense mechanism against viral invasion is the elimination of infected cells through apoptotic cell death. (dmu.edu)
  • Apoptosis induction during HSV-1 infection was initially recognized in human carcinoma HEp-2 cells, which undergo apoptosis when treated with a protein synthesis inhibitor during infection (Koyama and Adachi, 1997 J Gen Virol , 78, 2909-12). (dmu.edu)
  • The Human Papillomavirus E6 protein is a key mediator of HSV-1-dependent apoptosis in HeLa cells. (dmu.edu)
  • Strongly induced by the presence of single DNA strand breaks, ADPRT interacts with XRCC1 protein to participate in DNA repair and in the recovery of cells from DNA damage ( 18 - 21 ). (aacrjournals.org)
  • In cultured HL-60 cells treated with trans, trans -muconaldehyde, hydroquinone, and their mixtures, the formation of DNA-protein cross-links and DNA strand breaks was observed ( 12 ), and increased homologous recombination repair was detected in cultured Chinese hamster ovary cells administrated with phenol, catechol, and benzoquinone ( 22 ). (aacrjournals.org)
  • Cellular apoptosis susceptibility (CAS) is overexpressed in thyroid carcinoma and maintains tumor cell growth: A potential link to the BRAFV600E mutation. (nih.gov)
  • It has been shown that CCT6A protein expression levels are elevated in tumor tissues of patients with hepatocellular carcinoma and that the overall survival of these patients is relatively shorter [ 5 ] . (researchsquare.com)
  • These are the caspases, Bcl-2 family of proteins, tumor necrosis factor receptor (TNF-R) superfamily, and adaptor proteins [ 3 ]. (hindawi.com)
  • More than 20 years ago, it was initially predicted that hormones and growth factors might promote cell growth by binding and thereby inactivating tumor suppressors, as exemplified by the proposed complex formation between insulin and retinoblastoma protein (RB). (rjme.ro)
  • 7 Interestingly, expression levels of the Bcl-2 family of proteins change as tumors become more malignant or after treatment suggesting that expression of these survival proteins is critical not only for tumor development, but also for tumor progression and resistance to therapy. (bloodjournal.org)
  • Can be used as a broad spectrum caspase inhibitor in conjunction with apoptosis detection assays. (enzolifesciences.com)
  • DMSO concentration above 0.2% may cause cellular toxicity thus masking the effect of the caspase inhibitor. (enzolifesciences.com)
  • According to recent findings, FADD and caspase 8 are also recruited to the DISC of TNF-related apoptosis-inducing ligand R1 (TRAIL-R1) and TRAIL-R2 ( 7 , 37 , 71 ) and are essential for death induction via TRAIL-R2 ( 71 ). (asm.org)
  • This protein was reported to be specifically cleaved by CASP3 -like caspases , which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. (wikipedia.org)
  • Chen X, Wang Y, Chen YZ, Harry BL, Nakagawa A, Lee ES, Guo H, Xue D. Regulation of CED-3 caspase localization and activation by C. elegans nuclear-membrane protein NPP-14. (harvard.edu)
  • Mildronate pivotally zebeta generic cost (50 mg/kg) normalizes the increase in caspase-3, cellular apoptosis susceptibility protein (CAS) and iNOS expression. (moonlightingproduction.com)
  • Mildronate (50 mg/kg) normalizes the increase in caspase-3, buy keflex antibiotics lanoxin 50mg 0812 cellular apoptosis susceptibility protein (CAS) and iNOS expression. (revedecabane.com)
  • 1997). Fluorometric and colorimetric detection of caspase activity associated with apoptosis. (anaspec.com)
  • Activated caspase 8 can also cleave a small cytosolic protein called Bid, enabling Bid to bind to mitochondria and to release cytochrome c into the cytoplasm. (jimmunol.org)
  • In some cell types (type 1) sufficient amounts of caspase 8 are activated at the death-inducing signaling complex so as to efficiently initiate apoptosis, whereas others (type 2) form less caspase 8 and must use the mitochondrial pathway to amplify the Fas signal ( 8 ). (jimmunol.org)
  • In this study, we systematically investigated how protein phosphorylation affects susceptibility to caspase cleavage using an N-terminomic strategy, namely, a modified terminal amino isotopic labeling of substrates (TAILS) workflow, to identify proteins for which caspase-catalyzed cleavage is modulated by phosphatase treatment. (mcponline.org)
  • With its history as an original manufacturer, Abcepta has a deep and practical understanding of the production process for antibodies, peptides, and recombinant proteins. (abcepta.com)
  • Caspases are a family of aspartate-specific cysteine proteases that are necessary for execution of apoptosis. (asm.org)
  • Activated effector caspases cleave a variety of cellular protein substrates, leading to apoptotic cell death. (jimmunol.org)
  • For example, in apoptosis, caspases promote cell death via cleavage of key structural and enzymatic proteins that in some instances is inhibited by phosphorylation near the scissile bond. (mcponline.org)
  • The recent identification of a role for the importin β homolog transportin, in the nuclear import of heterogeneous nuclear ribonucleoprotein (hnRNP) A1 raised the possibility that different classes of nuclear proteins would be transported by different pathways, defined by the identity of the β subunit involved ( 11 , 12 ). (pnas.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Their metabolism is strictly regulated by cellular pathways, since dysregulation of metal homeostasis is responsible for many detrimental effects. (frontiersin.org)
  • They are involved in a variety of cellular pathways, from electrochemical gradient generation to enzyme active site formation, DNA replication, oxygen transport, and oxidative/nitrosative stress regulation. (frontiersin.org)
  • Although ion-specific transporters and metal-binding proteins exist, absorption/excretion pathways are highly interconnected and interdependent among different ionic species. (frontiersin.org)
  • The influx of data from these experiments has been utilized to build informative tools that aggregate and interpret these observations to place input proteins into predicted functionally related pathways [ 5 - 8 ]. (prolekare.cz)
  • Human Cdc42 is a small GTPase of the Rho family , which regulates signaling pathways that control diverse cellular functions including cell morphology , cell migration , endocytosis and cell cycle progression. (wikidoc.org)
  • While the initiation mechanisms of these pathway are different, both pathways converge (common pathway) resulting ultimately in cellular morphologic and biochemical alterations characteristic of apoptosis [ 5 , 6 ]. (hindawi.com)
  • The fusion protein seems to block promyelocytic differentiation in a dominant-negative manner by interfering with either retinoic acid- or PML-mediated transcription pathways. (thefreelibrary.com)
  • My general research interests lie in understanding how viruses manipulate cellular pathways to ensure their own propagation. (dmu.edu)
  • CAS (cellular apoptosis susceptibility contains 971 amino acids with 59% overall sequence homology as compared to yeast chromosome segregation homolog, CSE1. (thermofisher.com)
  • The NLS is a sequence of basic amino acids that tags the protein as cargo destined for the nucleus. (wikipedia.org)
  • Diverse stimuli control plant metabolism through a pair of protein kinases related to the adenosine monophosphate-activated protein kinase of mammals. (sciencemag.org)
  • These neurodegenerative maladies involve proteins that bind metals and mediate their metabolism through not well-defined mechanisms. (frontiersin.org)
  • In this work we focused on the effect of prion protein absence on copper and iron metabolism during development and adulthood. (frontiersin.org)
  • Altogether, these results reveal that the absence of the cellular prion protein impairs copper metabolism and copper-dependent oxidase activity, with ensuing alteration of iron mobilization from cellular storage compartments. (frontiersin.org)
  • Depending on which genes are activated or repressed, p53 can induce cell cycle arrest, DNA repair, apoptosis and senescence, as well as regulate other processes such as energy metabolism. (embopress.org)
  • ARHGEF11 is 1 of 85 activators of Rho GTPases that play a fundamental role in G protein signaling and therefore many aspects of cellular regulation ( 9 , 10 ), including β-cell apoptosis, insulin secretion ( 11 - 13 ), insulin signaling ( 14 - 18 ), and lipid metabolism ( 19 , 20 ). (diabetesjournals.org)
  • Clusters of about 75 molecules of the membrane protein syntaxin result from weak attraction among the proteins balanced by steric repulsion induced by crowding. (sciencemag.org)
  • Importin is a type of karyopherin that transports protein molecules from the cell's cytoplasm to the nucleus. (wikipedia.org)
  • To start to elucidate their role in the brain apoptosis of Bufo arenarum induced by cypermethrin (CY), the expression patterns of CAS and several cell adhesion molecules (CAMs) were established. (bvsalud.org)
  • We investigated the possible involvement of several molecules, including c-ABL, platelet-derived growth factor receptor (PDGFR), cellular FADD-like interleukin-1 alpha-converting enzyme-like inhibitory protein (c-FLIP)(L/S), Fas-associated DD kinase, p53, p21(WAF1), proteins of B-cell leukemia/lymphoma 2 (Bcl-2) family and cytochrome c. (nih.gov)
  • Important effectors lying downstream of PIP3 that promote tumorigenesis include such molecules as PDK1, Akt/protein kinase B (PKB), and the two mammalian target of rapamycin-containing complexes, mTOR1 and mTOR2 [10], [11]. (monossabios.com)
  • The Cas family of proteins can be divided into 4 functional domains: expression, interference, adaption, and ancillary. (wikipedia.org)
  • ALong with this correlation, in the absence of the CAS protein in a cell, there is an inhibition of apoptosis Along with being an inducer of apoptosis, CAS also plays a role in being a checkpoint for cell cycle. (wikipedia.org)
  • The induction of apoptosis by ChPL was found to be mediated through MAP kinase signaling inhibition. (frontiersin.org)
  • p21 Cip1 (alternatively p21 Waf1 ), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1 , is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, [5] though is primarily associated with inhibition of CDK2 . (wikipedia.org)
  • Address correspondence to Mary Shannon Moore, Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. (rupress.org)
  • This protein forms a trimeric complex with cyclin H and MAT1 , which functions as a Cdk-activating kinase (CAK). (wikidoc.org)
  • Several groups reported activity of the soluble CD95 ligand (CD95L) ( 38 ), whereas others ascribe the capacity to induce apoptosis to the membrane-bound form ( 66 , 74 ). (asm.org)
  • The cytoplasmic region of Fas contains a death domain that, upon ligand-induced clustering, forms a binding site for an adaptor protein called Fas-associated death domain protein (FADD). (jimmunol.org)
  • They affect susceptibility to bacterial and viral pathogens, constitute as risk factors for IgG or IgE mediated inflammatory diseases, and impact the development of many autoimmune conditions. (jove.com)
  • The antiviral restriction factor IFN-induced transmembrane protein 3 (IFITM3) inhibits cell entry of a number of viruses, and genetic diversity within IFITM3 determines susceptibility to viral disease in humans. (jci.org)
  • APOPTOSIS, a morphologically distinguished type of programmed cell death, is critical not only during development but also in the pathogenesis of a variety of diseases including cancer, autoimmune disease, viral infection, and neurodegenerative disorders. (bloodjournal.org)
  • Initially, apoptosis is triggered through the transcription of immediate early (α) viral genes (Sanfilippo, Chirimuuta et al. (dmu.edu)
  • During these later stages of the viral life cycle anti-apoptotic proteins are synthesized that prevent apoptotic cell death from proceeding. (dmu.edu)
  • Even though early studies that utilized the HEp-2 strain of HeLa cell provided information crucial to understanding the viral factors involved in HSV-dependent apoptosis (HDAP), analysis of host factor involvement was limited. (dmu.edu)
  • Evaluation of TV cell line viral susceptibility using conventional cell culture techniques. (bethlen-foundation.ro)
  • Proteins have been identified that mediate both inward and outward macromolecular movement and both processes appear to be regulated by some of the same factors (reviewed in refs. (pnas.org)
  • It was originally identified in S. cerevisiae (yeast) as a mediator of cell division , and is now known to influence a variety of signaling events and cellular processes in a variety of organisms from yeast to mammals. (wikidoc.org)
  • Lipocalin-2 is involved in multiple cellular processes including apoptosis, innate immunity and renal development. (abcam.com)
  • Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. (abcam.com)
  • This protein plays a role in the regulation of several cellular processes including embryonic lens fiber cell development increased T-cell susceptibility to apoptosis and chondrocyte terminal differentiation. (bio-rad.com)
  • These proteins are involved with a number of cellular processes such as senescence, apoptosis and transcriptional regulation. (thefreelibrary.com)
  • Whether related to hypoxia, loss of nutrients, induction of nonspecific inflammatory reactions, or immune effectors implicated in the development of autoimmune disease or allograft rejection, the final outcome of these processes is destruction of the transplanted islets by apoptosis. (rupress.org)
  • A nucleocytoplasmic transport protein that binds to ALPHA KARYOPHERINS and RAN GTP BINDING PROTEIN inside the CELL NUCLEUS and participates in their export into CYTOPLASM. (curehunter.com)
  • The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin - CDK2 , - CDK1 , and - CDK4 /6 complexes, and thus functions as a regulator of cell cycle progression at G 1 and S phase . (wikipedia.org)
  • Released cytochrome c binds to apoptosis-activating factor 1, forming a complex that in the presence of ATP can bind and promote autocatalytic activation of procaspase 9. (jimmunol.org)
  • The use Cellular Apoptosis Susceptibility Protein Clone 30F12 is much more reproducable than with a polyclonal antibody. (antibody-antibodies.com)
  • 4,5 Moreover, immunohistochemical analysis of the Bcl-2 protein has indicated that alterations in either the levels or patterns of Bcl-2 expression, or both, can occur in a variety of solid tumors. (bloodjournal.org)
  • Post-translational modifications of proteins regulate diverse cellular functions, with mounting evidence suggesting that hierarchical cross-talk between distinct modifications may fine-tune cellular responses. (mcponline.org)
  • It is also associated with the regulation of APOPTOSIS and microtubule assembly. (curehunter.com)
  • To study the regulation of germline apoptosis, we analyzed the midway mutant, in which egg chambers undergo premature nurse cell death and degeneration. (genetics.org)
  • A variety of malignancies including hepatocellular carcinoma (HCC) show de-regulation of nuclear transport factors such as overexpression of the exportin Cellular Apoptosis Susceptibility (CAS). (oncotarget.com)
  • Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. (etigararunway.ro)
  • Cell division control protein 42 homolog , also known as Cdc42 , is a protein involved in regulation of the cell cycle . (wikidoc.org)
  • This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. (wikidoc.org)
  • Apoptosis is a well defined mode of cell death which plays an imperative role in the development, regulation, and maintenance of the cell populations in multicellular organisms. (hindawi.com)
  • Understanding the regulation of IP in normal pubertal mammary gland development, as well as in carcinogenesis, may provide relevant information about how other environmental factors (i.e., endocrine disrupters, toxicants) may increase susceptibility to mammary cancer. (bcerp.org)
  • A key factor contributing to drug resistance is apoptosis suppression associated with the upregulation of anti-apoptotic Bcl-2 family proteins. (frontiersin.org)
  • Specifically, the anti-apoptotic Mcl-1 protein has been shown to play a significant role in drug resistance, making it an important therapeutic target. (frontiersin.org)
  • Specifically, the upregulation of the anti-apoptotic Bcl-2 family proteins has been shown to suppress cell death induced by cytotoxic anticancer drugs ( Yip and Reed, 2008 ). (frontiersin.org)
  • This renders the anti-apoptotic Bcl-2 proteins important targets in cancer drug design ( Yip and Reed, 2008 ). (frontiersin.org)
  • NAT10 (N-acetyltransferase 10) is a nucleolar protein, but may show subcellular redistribution in colorectal carcinoma. (aacrjournals.org)
  • The transcription factor p53 is a tumour suppressor that is often referred to as 'the cellular gatekeeper', as it is an essential regulator of cellular stress responses [ 1 ]. (embopress.org)
  • It is broadly accepted that these modifications contribute to the increase in p53 protein stability and modulate its function as a transcription factor [ 4 , 5 ]. (embopress.org)
  • Independently of its effects on transcription, cytoplasmic p53 has been reported to trigger apoptosis, as well as necrosis. (embopress.org)
  • The p53 protein has been well characterized as a sequence‐specific transcription factor [ 12 ]. (embopress.org)
  • Proteins that contain nuclear localization sequences are recognized in the cytoplasm and delivered to the nucleus by the heterodimeric importin complex. (pnas.org)
  • In contrast to protein import, how RNAs are exported from the nucleus to the cytoplasm is less well understood. (pnas.org)
  • Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. (nih.gov)
  • The NLS-Importin α-Importin β trimer dissociates after binding to Ran GTP inside the nucleus, with the two importin proteins being recycled to the cytoplasm for further use. (wikipedia.org)
  • Once the cargo protein is bound, importin-β interacts with the NPC, and the complex diffuses into the nucleus from the cytoplasm. (wikipedia.org)
  • The concentration of RanGTP is kept low in the cytoplasm and high inside the nucleus by localizing the Ran GTPase activating protein (GAP) to the cytoplasm and the Ran guanine nucleotide exchange factor (GEF) (RCC1) to the nucleus. (rupress.org)
  • Your search returned 7 Cellular Apoptosis Susceptibility ELISA ELISA Kit across 4 suppliers. (biocompare.com)
  • PSE1 was previously identified in a screen for effectors of protein secretion but its mechanism of action was not defined ( 23 ). (pnas.org)
  • Rho guanine nucleotide exchange factor 11 (ARHGEF11), located on chromosome 1q21, is involved in G protein signaling and is a pathway known to play a role in both insulin secretion and action. (diabetesjournals.org)
  • We hypothesized that variation in ARHGEF11 may affect insulin secretion and/or action and, as a result, type 2 diabetes susceptibility. (diabetesjournals.org)
  • In order to study the specificity of cellular immune responses against SARS CoV-2 and potential immunity caused by other human Corona Viruses, Abcepta provides Spike peptide individually, as pools and in plate. (abcepta.com)
  • However, the differential ability of Bcl-XL and Bcl-2 against chemotherapy-induced apoptosis was not universal and appeared to be dependent on the molecular mechanism or cellular target of the drug rather than its cell-cycle phase specificity. (bloodjournal.org)
  • The primary function of importin is to mediate the translocation of proteins with nuclear localization signals into the nucleus, through nuclear pore complexes (NPC), in a process known as the nuclear protein import cycle. (wikipedia.org)
  • The cytoprotective effect of A20 against apoptosis correlates with and is dependent on the abrogation of cytokine-induced NO production. (rupress.org)
  • Susceptibility to HSV-1-dependent apoptosis correlates with cellular transformation status. (dmu.edu)
  • Under normal physiological conditions, the p53 protein is maintained at low intracellular levels by its negative regulator, the E3 ubiquitin ligase Mdm2, which targets p53 for ubiquitin‐dependent degradation through the proteasome [ 2 ]. (embopress.org)
  • Extrinsic/death receptor activated pathway involves the initiation of apoptosis through ligation of plasma membrane death receptors whereas intrinsic/mitochondrial cell death pathway involves initiation of apoptosis as a result of disturbance of intracellular homeostasis and mitochondria being critical executioner of cell death. (hindawi.com)
  • For instance, DNA damage activates two main p53‐dependent responses: cell cycle arrest and attendant DNA repair or apoptosis (cell death). (embopress.org)
  • Apart from necrotic cell death occurring upon tissue injury, several distinct types of apoptosis have been observed. (asm.org)
  • Apoptosis, or programmed cell death, is critical for tissue homeostasis in multicellular organisms. (asm.org)
  • Proteins do not exert their function in isolation, but rather exist within intricate networks of molecular relationships that can be revealed through high-throughput analyses of protein-protein interactions, tissue-specific expressivity and shared regulatory elements to name a few. (prolekare.cz)
  • Benzene metabolites bind covalently to macromolecules, such as proteins and DNA in the tissue, and therefore cause genotoxicity ( 10 , 12 ) as a result of oxidative damage to DNA or DNA double-strand breaks caused by reactive oxygen species. (aacrjournals.org)
  • Cellular Apoptosis Susceptibility Protein Clone 30F12 monclonal andibody monoclonal antobodies are directed against a specific epitope. (antibody-antibodies.com)
  • Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology. (wikiwand.com)
  • As part of a heterodimer, importin-β mediates interactions with the pore complex, while importin-α acts as an adaptor protein to bind the nuclear localization signal (NLS) on the cargo. (wikipedia.org)
  • A large proportion of the importin-α adaptor protein is made up of several armadillo repeats (ARM) arranged in tandem. (wikipedia.org)
  • Importin can perform this function as a monomeric importin-β protein, but usually requires the presence of importin-α, which acts as an adaptor to cargo proteins (via interactions with the NLS). (wikipedia.org)
  • The cellular apoptosis susceptibility protein (CAS) is an exportin which in the nucleus is bound to RanGTP. (wikipedia.org)
  • The yeast Saccharomyces cerevisiae contains three proteins (Kap104p, Pse1p, and Kap123p) that share similarity to the 95-kDa β subunit of the nuclear transport factor importin (also termed karyopherin and encoded by KAP95/RSL1 in yeast). (pnas.org)
  • Nuclear transport receptors are an integral part of the transport system and belong predominantly to the karyopherin protein superfamily [ 5 ]. (oncotarget.com)
  • Mouse Lipocalin-2 has 81% and 62% protein sequence identity to rat and human Lipocalin-2, respectively. (abcam.com)
  • Transduction of Bcl-2 completely protects human EC from huCTL, but has no effect on huCTL-mediated killing of porcine EC despite its efficacy vs drug-induced apoptosis. (jimmunol.org)
  • These data reveal differences in the susceptibility of human and porcine targets to huCTL. (jimmunol.org)
  • Human papillomavirus HPV - Early Vaccination paraziti v jatrech Dysbiosis gut hpv wart virus symptoms, papiloma en perros en la boca tratamiento hpv warts child. (coboramlaprima.ro)
  • Virus del papiloma humano tambien se busco papiloma humano virus concepto, papiloma humano en hombres sintomas human papillomavirus genome sequence tratamiento eozinofile crescute paraziti. (bethlen-foundation.ro)
  • The salient point of death receptor signaling is the formation of a multimolecular complex of proteins triggered by receptor cross-linking either with agonistic antibodies ( 77 ) or with death ligands. (asm.org)
  • For new targets we consult with leading experts to accelerate development of antibodies that will propel state-of-the-art research in cellular health and disease. (abcepta.com)
  • Not to be confused with cellular differentiation . (bioscience.ws)
  • Our knowledge of the mechanism by which proteins are imported into and RNAs exported from the nucleus has grown significantly in recent years. (pnas.org)
  • Import of proteins into the nucleus is a highly conserved, multistep process initiated by recognition of a nuclear localization sequence (NLS) by a cognate receptor, followed by docking of the complex at the nuclear pore, and GTP-dependent translocation into the nucleoplasm. (pnas.org)
  • Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. (nih.gov)
  • A 60 kDa cytosolic protein, essential for protein import into the nucleus, and with a 44% sequence identity to SRP1p, was purified from Xenopus eggs. (wikipedia.org)
  • These groups found that importin-α requires another protein, importin-β to function, and that together they form a receptor for nuclear localization signals (NLS), thus allowing transport into the nucleus. (wikipedia.org)
  • Now that the importin-α/cargo complex is free of importin-β, the cargo protein can be released into the nucleus. (wikipedia.org)
  • Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS. (harvard.edu)
  • One mechanism that has been proposed to trigger the accumulation of TDP-43 which may lead to the cause of MND is a defective transport system of the protein into the nucleus - the control centre of the cell. (wordpress.com)
  • The research group first silenced (quite literally stopping the function) 82 proteins that are known to be involved with the transport of cargo, such as TDP-43 into the nucleus. (wordpress.com)
  • From this they identified five proteins that when silenced result in an accumulation of TDP-43 outside of the nucleus. (wordpress.com)
  • However, three of these are known to be involved in the general transport of all proteins into the nucleus and so were discarded from the study. (wordpress.com)
  • The two proteins that were found to cause an accumulation of TDP-43 outside of the nucleus are called CAS (which stands for Cellular Apoptosis Susceptibility) and Karopherin-β1. (wordpress.com)
  • The receptor for the canonical NLS is a heterodimeric protein complex variously called importin or karyopherin, composed of an α (NLS-binding) and a β (docking) subunit ( 3 - 6 ). (pnas.org)
  • However, cross-linkage of cell surface-bound IgE by multivalent antigen causes receptor aggregation, triggering explosive cellular degranulation whereby mediators of allergy such as cellular degranulation whereby mediators of allergy such as histamine and seretonin are released. (google.com)
  • Many nuclear-targeted proteins are transported through the nuclear pore complex (NPC) by the importin-alpha:beta receptor. (nih.gov)
  • Apoptosis is initiated by a variety of stimuli, including growth factor withdrawal ("death by neglect"), UV or γ-irradiation, chemotherapeutic drugs, and death receptor signals. (asm.org)
  • These studies identify ANTXR1, a class of receptor that is shared by a mammalian virus and a bacterial toxin, as the cellular receptor for SVV. (jci.org)
  • To make sure the results were not a fluke they repeated their experiments in a total of three cellular models originating from humans and mice. (wordpress.com)
  • The recently completed yeast genome sequence identified three additional genes encoding proteins with similarity to importin β. (pnas.org)
  • Except for lymphotoxin α, the death ligands are type II transmembrane proteins which can be converted into a soluble form by the activity of metalloproteases. (asm.org)
  • NO-mediated toxicity is the predominant mechanism responsible for β cell dysfunction and apoptosis induced by soluble mediators. (rupress.org)
  • This chimeric protein is prepared by genetically fusing the Fc region of the mouse IgE molecule to PE 40 , a truncated form of PE lacking the cell binding domain. (google.com)
  • Apoptosis is a genetically programmed form of cell death which is indispensable for development and homeostasis of multicellular organism. (hindawi.com)
  • However p21 may inhibit apoptosis and does not induce cell death on its own. (wikipedia.org)
  • Translocation through the nuclear pore is driven by GTP hydrolysis, catalyzed by the small ras-related GTP-binding protein Ran and its regulators ( 7 - 10 ). (pnas.org)
  • Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. (wikipedia.org)
  • In summary, whereas mitochondrial base substitution and deletions previously have been shown to correlate with premature and natural aging, respectively, we show that a high level of apyrimidinic sites lead to mitochondrial DNA cytotoxicity, which causes apoptosis, followed by neurodegeneration. (asm.org)
  • Depending on the binding site and binding partner the encoded protein can be a transcriptional activator or repressor. (bio-rad.com)
  • The killing moiety used in the chimeric protein of the present invention is the bacterial toxin Pseudomonas exotoxin (PE) (a product of Pseudomonas aeruginosa ). (google.com)
  • Mice deficient in Lipocalin-2 appear normal but have increased susceptibility to bacterial infection. (abcam.com)