Chondrosarcoma: A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)Cartilage: A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.Cartilage, Articular: A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.Chondrosarcoma, Mesenchymal: A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed with islands of cartilaginous matrix. Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in the younger age group and are highly metastatic. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1456)Cartilage Diseases: Pathological processes involving the chondral tissue (CARTILAGE).Chondrocytes: Polymorphic cells that form cartilage.Chondroma: A benign neoplasm derived from mesodermal cells that form cartilage. It may remain within the substance of a cartilage or bone (true chondroma or enchondroma) or may develop on the surface of a cartilage (ecchondroma or ecchondrosis). (Dorland, 27th ed; Stedman, 25th ed)Nasal Cartilages: Hyaline cartilages in the nose. There are five major nasal cartilages including two lateral, two alar, and one septal.Proteoglycans: Glycoproteins which have a very high polysaccharide content.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.Ear Cartilage: Cartilage of the EAR AURICLE and the EXTERNAL EAR CANAL.Laryngeal Cartilages: The nine cartilages of the larynx, including the cricoid, thyroid and epiglottic, and two each of arytenoid, corniculate and cuneiform.Hyaline Cartilage: A type of CARTILAGE characterized by a homogenous amorphous matrix containing predominately TYPE II COLLAGEN and ground substance. Hyaline cartilage is found in ARTICULAR CARTILAGE; COSTAL CARTILAGE; LARYNGEAL CARTILAGES; and the NASAL SEPTUM.Knee Joint: A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.Aggrecans: Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.Cartilage Oligomeric Matrix Protein: Major component of chondrocyte EXTRACELLULAR MATRIX of various tissues including bone, tendon, ligament, SYNOVIUM and blood vessels. It binds MATRILIN PROTEINS and is associated with development of cartilage and bone.Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)Collagen Type II: A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.Extracellular Matrix Proteins: Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).Glycosaminoglycans: Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.Matrilin Proteins: PROTEOGLYCANS-associated proteins that are major components of EXTRACELLULAR MATRIX of various tissues including CARTILAGE; and INTERVERTEBRAL DISC structures. They bind COLLAGEN fibers and contain protein domains that enable oligomer formation and interaction with other extracellular matrix proteins such as CARTILAGE OLIGOMERIC MATRIX PROTEIN.Chondrogenesis: The formation of cartilage. This process is directed by CHONDROCYTES which continually divide and lay down matrix during development. It is sometimes a precursor to OSTEOGENESIS.Growth Plate: The area between the EPIPHYSIS and the DIAPHYSIS within which bone growth occurs.Enchondromatosis: Benign growths of cartilage in the metaphyses of several bones.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Tibia: The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.Femur: The longest and largest bone of the skeleton, it is situated between the hip and the knee.Fractures, Cartilage: Breaks in CARTILAGE.Matrix Metalloproteinase 13: A secreted matrix metalloproteinase that plays a physiological role in the degradation of extracellular matrix found in skeletal tissues. It is synthesized as an inactive precursor that is activated by the proteolytic cleavage of its N-terminal propeptide.Stifle: In horses, cattle, and other quadrupeds, the joint between the femur and the tibia, corresponding to the human knee.Patella: The flat, triangular bone situated at the anterior part of the KNEE.Ribs: A set of twelve curved bones which connect to the vertebral column posteriorly, and terminate anteriorly as costal cartilage. Together, they form a protective cage around the internal thoracic organs.Hyaluronic Acid: A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.Menisci, Tibial: The interarticular fibrocartilages of the superior surface of the tibia.Nasal Septum: The partition separating the two NASAL CAVITIES in the midplane. It is formed by the SEPTAL NASAL CARTILAGE, parts of skull bones (ETHMOID BONE; VOMER), and membranous parts.Chondroitin Sulfates: Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.Chordoma: A malignant tumor arising from the embryonic remains of the notochord. It is also called chordocarcinoma, chordoepithelioma, and notochordoma. (Dorland, 27th ed)Epiphyses: The head of a long bone that is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Humerus: Bone in humans and primates extending from the SHOULDER JOINT to the ELBOW JOINT.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Arytenoid Cartilage: One of a pair of small pyramidal cartilages that articulate with the lamina of the CRICOID CARTILAGE. The corresponding VOCAL LIGAMENT and several muscles are attached to it.Procollagen N-Endopeptidase: An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical region of the procollagen molecule with the formation of collagen. Absence or deficiency of the enzyme causes accumulation of procollagen which results in the inherited connective tissue disorder--dermatosparaxis. EC 3.4.24.14.Cricoid Cartilage: The small thick cartilage that forms the lower and posterior parts of the laryngeal wall.Thyroid Cartilage: The largest cartilage of the larynx consisting of two laminae fusing anteriorly at an acute angle in the midline of the neck. The point of fusion forms a subcutaneous projection known as the Adam's apple.Osteochondritis: Inflammation of a bone and its overlaying CARTILAGE.Weight-Bearing: The physical state of supporting an applied load. This often refers to the weight-bearing bones or joints that support the body's weight, especially those in the spine, hip, knee, and foot.Joints: Also known as articulations, these are points of connection between the ends of certain separate bones, or where the borders of other bones are juxtaposed.Chondroitinases and Chondroitin Lyases: Enzymes which catalyze the elimination of glucuronate residues from chondroitin A,B, and C or which catalyze the hydrolysis of sulfate groups of the 2-acetamido-2-deoxy-D-galactose 6-sulfate units of chondroitin sulfate. EC 4.2.2.-.Exostoses, Multiple Hereditary: Hereditary disorder transmitted by an autosomal dominant gene and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation.Tissue Engineering: Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.Femoral NeoplasmsMyxosarcoma: A sarcoma, usually a liposarcoma or malignant fibrous histiocytoma, with an abundant component of myxoid tissue resembling primitive mesenchyme containing connective tissue mucin. (Stedman, 25th ed)Skull Base Neoplasms: Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).Compressive Strength: The maximum compression a material can withstand without failure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p427)Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Femur Head: The hemispheric articular surface at the upper extremity of the thigh bone. (Stedman, 26th ed)Synovial Membrane: The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.Extracellular Matrix: A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.Synovial Fluid: The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.Stress, Mechanical: A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.Biomechanical Phenomena: The properties, processes, and behavior of biological systems under the action of mechanical forces.Knee Injuries: Injuries to the knee or the knee joint.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Periosteum: Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.Collagen Type XI: A fibrillar collagen found primarily in interstitial CARTILAGE. Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits.Lectins, C-Type: A class of animal lectins that bind to carbohydrate in a calcium-dependent manner. They share a common carbohydrate-binding domain that is structurally distinct from other classes of lectins.Mandibular Condyle: The posterior process on the ramus of the mandible composed of two parts: a superior part, the articular portion, and an inferior part, the condylar neck.Osteochondroma: A cartilage-capped benign tumor that often appears as a stalk on the surface of bone. It is probably a developmental malformation rather than a true neoplasm and is usually found in the metaphysis of the distal femur, proximal tibia, or proximal humerus. Osteochondroma is the most common of benign bone tumors.Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)Arthritis, Experimental: ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.Lubrication: The application of LUBRICANTS to diminish FRICTION between two surfaces.Pelvic Bones: Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Sulfates: Inorganic salts of sulfuric acid.SOX9 Transcription Factor: A SOXE transcription factor that plays a critical role in regulating CHONDROGENESIS; OSTEOGENESIS; and male sex determination. Loss of function of the SOX9 transcription factor due to genetic mutations is a cause of CAMPOMELIC DYSPLASIA.Neoplasms, Connective and Soft Tissue: Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.Uronic Acids: Acids derived from monosaccharides by the oxidation of the terminal (-CH2OH) group farthest removed from the carbonyl group to a (-COOH) group. (From Stedmans, 26th ed)Chondroitin Sulfate Proteoglycans: Proteoglycans consisting of proteins linked to one or more CHONDROITIN SULFATE-containing oligosaccharide chains.Chondromatosis, Synovial: Rare, benign, chronic, progressive metaplasia in which cartilage is formed in the synovial membranes of joints, tendon sheaths, or bursae. Some of the metaplastic foci can become detached producing loose bodies. When the loose bodies undergo secondary calcification, the condition is called synovial osteochondromatosis.Anterior Cruciate Ligament: A strong ligament of the knee that originates from the posteromedial portion of the lateral condyle of the femur, passes anteriorly and inferiorly between the condyles, and attaches to the depression in front of the intercondylar eminence of the tibia.Arthroplasty, Subchondral: Surgical techniques used to correct or augment healing of chondral defects in the joints (CARTILAGE, ARTICULAR). These include abrasion, drilling, and microfracture of the subchondral bone to enhance chondral resurfacing via autografts, allografts, or cell transplantation.Matrix Metalloproteinase 3: An extracellular endopeptidase of vertebrate tissues similar to MATRIX METALLOPROTEINASE 1. It digests PROTEOGLYCAN; FIBRONECTIN; COLLAGEN types III, IV, V, and IX, and activates procollagenase. (Enzyme Nomenclature, 1992)Microscopy, Polarization: Microscopy using polarized light in which phenomena due to the preferential orientation of optical properties with respect to the vibration plane of the polarized light are made visible and correlated parameters are made measurable.Tissue Culture Techniques: A technique for maintaining or growing TISSUE in vitro, usually by DIFFUSION, perifusion, or PERFUSION. The tissue is cultured directly after removal from the host without being dispersed for cell culture.Injections, Intra-Articular: Methods of delivering drugs into a joint space.Collagen Type IX: A fibril-associated collagen usually found crosslinked to the surface of COLLAGEN TYPE II fibrils. It is a heterotrimer containing alpha1(IX), alpha2(IX) and alpha3(IX) subunits.Hyoid Bone: A mobile U-shaped bone that lies in the anterior part of the neck at the level of the third CERVICAL VERTEBRAE. The hyoid bone is suspended from the processes of the TEMPORAL BONES by ligaments, and is firmly bound to the THYROID CARTILAGE by muscles.Chondroitin: A mucopolysaccharide constituent of chondrin. (Grant & Hackh's Chemical Dictionary, 5th ed)Collagenases: Enzymes that catalyze the degradation of collagen by acting on the peptide bonds.Bone Development: The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.Friction: Surface resistance to the relative motion of one body against the rubbing, sliding, rolling, or flowing of another with which it is in contact.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Scapula: Also called the shoulder blade, it is a flat triangular bone, a pair of which form the back part of the shoulder girdle.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Collagen Type X: A non-fibrillar collagen found primarily in terminally differentiated hypertrophic CHONDROCYTES. It is a homotrimer of three identical alpha1(X) subunits.Maxillary Neoplasms: Cancer or tumors of the MAXILLA or upper jaw.Sternum: A long, narrow, and flat bone commonly known as BREASTBONE occurring in the midsection of the anterior thoracic segment or chest region, which stabilizes the rib cage and serves as the point of origin for several muscles that move the arms, head, and neck.Matrix Metalloproteinase 1: A member of the metalloproteinase family of enzymes that is principally responsible for cleaving FIBRILLAR COLLAGEN. It can degrade interstitial collagens, types I, II and III.

*Chondroblast

... mesenchymal progenitors originate from the mesoderm. These cells, when forming from the mesoderm, specifically form from ... These cells are extremely important in Chondrogenesis due to their role in forming both the Chondrocytes and cartilage matrix ... Chondrosarcoma is a more malignant type of tumor, but most are low grade tumors and often appear in the axial skeletal region. ... Extrinsic environmental factors act upstream in determining what cell type will form out of any particular mesenchymal ...

*Chondroblastoma

It is thought to arise from an outgrowth of immature cartilage cells (chondroblasts) from secondary ossification centers, ... Romeo et al have observed chondroblastoma neoplasms to be composed of mesenchymal cells that have completed normal ... clear cell chondrosarcomas, and enchondromas (this list is not exhaustive). Chondroblastoma has not been known to spontaneously ... The work of Aigner et al suggests that chondroblastoma should be reclassified as a bone-forming neoplasm versus a cartilaginous ...

*Chondrosarcoma

... is a cancer composed of cells derived from transformed cells that produce cartilage. Chondrosarcoma is a member ... Because chondrosarcomas are rare, they are treated at specialist hospitals with Sarcoma Centers. Surgery is the main form of ... IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal ... Therapeutic molecular targets in human chondrosarcoma .Int J Exp Pathol 2010; 91:387-93 Chondrosarcoma of Bone Chondrosarcoma ...

*Osteosarcoma

Depending on the features of the tumor cells present (whether they resemble bone cells, cartilage cells, or fibroblast cells), ... Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchymal origin (and ... These right angles form what is known as a Codman triangle, which is characteristic but not diagnostic of osteosarcoma. ... Differential diagnosis of the osteosarcoma of the skull in particular includes, among others, chondrosarcoma and the ...

*List of OMIM disorder codes

T cell-negative, B-cell/natural killer-cell positive; 608971; CD3D Severe combined immunodeficiency, T cell-negative, B-cell/ ... GDF5 Chondrosarcoma; 215300; EXT1 Chondrosarcoma, extraskeletal myxoid; 612237; TAF15 Chondrosarcoma, extraskeletal myxoid; ... infantile form; 266510; PEX26 Refsum disease, infantile form; 266510; PXMP3 Refsum disease, infantile; 266510; PEX1 Renal ... RSPO4 Anterior segment mesenchymal dysgenesis; 107250; FOXE3 Anterior segment mesenchymal dysgenesis; 107250; PITX3 ...

*Osteoid osteoma

Chondrosarcoma *Mesenchymal chondrosarcoma. *Myxoid chondrosarcoma. *Osteochondroma *Osteochondromatosis. *Chondromyxoid ... The usual appearance included a fibrovascular stroma with numerous osteoblasts, osteoid tissue, well-formed woven bone, and ... Tumours of bone and cartilage (ICD-O 9180-9269) (C40-C41/D16, 170/213) ... into the tumor nidus through a cannulated needle under CT guidance and heat is applied locally to destroy tumor cells. Since ...
Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs. Interleukin-8 (IL-8), a chemokine with a defining CXC amino acid motif, is known to possess tumorigenic and proangiogenic properties. Over-expression of IL-8 has been detected in many human tumors. However, the effects of IL-8 in migration and integrin expression in chondrosarcoma cells are largely unknown. In this study, we found that IL-8 increased the migration and the expression of αvβ3 integrin in human chondrosarcoma cells. Activations of phosphatidylinositol 3-kinase (PI3K), Akt, and AP-1 pathways after IL-8 treatment were demonstrated, and IL-8-induced expression of integrin and migration activity was inhibited by the specific inhibitor and mutant of PI3K, Akt, and AP-1 cascades. Taken together, our results indicated ...
article{52f6a2c0-7074-42f4-ae84-0c0dbf6711b3, abstract = {,p,Rat chondrosarcoma chondrocytes were labeled with [,sup,3,/sup,H]serine or [,sup,3,/sup,H]mannose as a precursor. Intracellular proteoglycan core protein precursor was purified from cell lysates by immunoprecipitation with polyclonal antibodies against the hyaluronic acid-binding region, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The core precursor was eluted from the gels and treated with alkaline borohydride in order to convert serine residues substituted with xylose or N-acetylgalactosamine to alanine (or with alkaline sulfite to convert them to cysteic acid). After acid hydrolysis, the proportions of labeled serine and alanine (or cysteic acid) were determined by high performance liquid chromatography, and the results were compared with those obtained for the completed proteoglycan molecules isolated from the same cultures. In the completed proteoglycans, about 55% of the serine ...
OBJECTIVE: To determine whether, in human fibroblasts and chondrosarcoma cells, the regulation of interleukins (IL)-6, 8, and 11 and matrix metalloproteinases (MMP)-1, 3, and 13, and their tissue inhibitor TIMP-1, depends on the transcription factor nuclear factor-kappaB (NF-kappaB). METHODS: Fibroblasts and chondrosarcoma cells were effectively infected with an adenovirus encoding human IkappaBalpha, and inhibition of NF-kappaB function was observed. The induction of MMP and IL-6, 8, and 11 by various stimuli was assessed by ELISA. RESULTS: The induction of IL-6 and IL-8 clearly depended on NF-kappaB in both fibroblasts and chondrosarcoma cells, irrespective of stimulus, but IkappaBalpha overexpression had little effect on IL-11. MMP-1, -3, and -13 were also inhibited, but TIMP-1 was unaffected. CONCLUSION: NF-kappaB appears to play an important and selective role in MMP induction in human fibroblasts and ...
55 year old male with dedifferentiated chondrosarcoma and pathological fracture. Final Diagnosis: Left proximal femur and soft tissues, en bloc excision: Dedifferentiated chondrosarcoma High grade, grade 3/3 Maximum size 14.6 cm Tumor is ba...
Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin (PG) synthase, has been implicated in tumor metastasis. Interaction of COX-2 with its specific EP receptors on the surface of cancer cells has been reported to induce cancer invasion. However, the effects of COX-2 on migration activity in human chondrosarcoma cells are mostly unknown. In this study, we examined whether COX-2 and EP interaction are involved in metastasis of human chondrosarcoma. We found that over-expression of COX-2 or exogenous PGE2 increased the migration of human chondrosarcoma cells. We also found that human chondrosarcoma tissues and chondrosarcoma cell lines had significant expression of the COX-2 which was higher than that in normal cartilage. By using pharmacological inhibitors or activators or genetic inhibition by the EP receptors, we ...
Human chondrosarcomas do not respond to current chemotherapies or radiation therapy, and their size and histological appearance do not reliably predict the risk of local recurrence and metastases, making selection of surgical treatment difficult. Identifying mechanisms responsible for the proliferation and invasive behavior of these tumors would be of immense clinical value. We hypothesized that telomerase expression is one of these mechanisms. We detected telomerase expression in 7 of 16 chondrosarcomas, but cells cultured from telomerase-negative chondrosarcomas acquired strong telomerase activity and lost tumor suppressor activity after their establishment in culture. These changes were associated with accelerated indefinite cell proliferation, morphological transition, and increased invasive activity, indicating that telomerase activation and loss of cell cycle control leads to the emergence of aggressive cells from ...
In this study, we investigated the anticancer effects of a new benzimidazole derivative, 1-benzyl-2-phenyl -benzimidazole (BPB), in human chondrosarcoma cells. BPB-mediated apoptosis was assessed by the MTT assay and flow cytometry analysis. The in vivo efficacy was examined in a JJ012 xenograft model. Here we found that BPB induced apoptosis in human chondrosarcoma cell lines (JJ012 and SW1353) but not in primary chondrocytes. BPB induced upregulation of Bax, Bad and Bak, downregulation of Bcl-2, Bid and Bcl-XL and dysfunction of mitochondria in chondrosarcoma. In addition, BPB also promoted cytosolic releases AIF and Endo G. Furthermore, it triggered extrinsic death receptor-dependent pathway, which was characterized by activating Fas, FADD and caspase-8. Most importantly, animal studies revealed a dramatic 40% reduction in tumor volume after 21 days of treatment. Thus, BPB may be a novel anticancer agent for the treatment of ...
BioAssay record AID 79237 submitted by ChEMBL: In vitro cytotoxicity in chondrosarcoma cell line (H-EMC-SS) by Alamar blue assay.
Chondrosarcomas are malignant cartilage tumors that do not respond to traditional chemotherapy or radiation. The 5-year survival rate of histologic grade III chondrosarcoma is less than 30%. To achieve a greater understanding of chondrosarcoma tumorigenesis, a model for human chondrosarcoma has been established in a rat system. The model, known as the Swarm rat chondrosarcoma (SRC), resembles human chondrosarcoma and provides a system to study tumor growth and progression. Here we examined the influence of the tumor microenvironment and the impact of genome-wide hypomethylation on the behavior of SRC tumors, two factors known to contribute fundamentally to the development and progression of solid tumors. Previous studies with SRC revealed that tumor microenvironment can significantly influence chondrosarcoma malignancy, but the underlying biologic mechanisms ...
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Myxofibrosarcoma (MFS) is characterized by abundant myxoid stroma, a wide spectrum of cytological atypia, and frequent local recurrence. Some soft tissue tumors with myxoid stroma can histologically mimic MFS, but have different biological behaviors. Here we sought to identify a useful diagnostic marker for MFS. After our analysis of the gene expression dataset from the Gene Expression Omnibus database, we focused on claudin 6 (CLDN 6). The status of CLDN 6 was assessed by immunohistochemistry in 61 samples of MFS and other (benign) myxoid soft tissue tumors (28 myxoma samples, 12 nodular fasciitis samples), 18 low-grade fibromyxoid sarcoma, 30 myxoid liposarcoma, 29 extraskeletal myxoid chondrosarcoma and 27 dedifferentiated liposarcoma with myxoid feature samples ...
Ollier disease and Maffucci syndrome are rare syndromes in which there is deforming dysplasia of cartilage, primarily but not exclusively involving the metaphyses and diaphyses of long bones. In a minority of patients, dysplasia can lead to sarcomatous degeneration, producing chondrosarcomas. There also appears to be an association with other neoplasms. Little has been written about the association between Ollier disease and intracranial tumors, and these papers have largely consisted of case reports in adults. The authors present the case of a 6-year-old girl with left arm osseous changes consistent with Ollier disease and a biopsy-proven thalamic glioblastoma multiforme. They then examine the co-occurrence of brain tumors in conjunction with a dyschondroplasia syndrome in children and adolescents to assess the presentation, treatment offered, and disease course of similar cases.. Eight other such cases were identified, 6 ...
The Meckelian Cartilage, also known as "Meckels Cartilage", is a piece of cartilage from which the mandibles (lower jaws) of vertebrates evolved. Originally it was the lower of two cartilages which supported the first branchial arch in early fish. Then it grew longer and stronger, and acquired muscles capable of closing the developing jaw.[1]. In early fish and in chondrichthyans (cartilaginous fish such as sharks), the Meckelian Cartilage continued to be the main component of the lower jaw. But in the adult forms of osteichthyans (bony fish) and their descendants (amphibians, reptiles, birds, mammals), the cartilage was covered in bone - although in their embryos the jaw initially develops as the Meckelian Cartilage. In all tetrapods the ...
There are many causes for painful worn cartilage in the knee joint: arthritis, arthrosis, traumas with bone- or cartilage lesions or metabolic disorders like gout or hemochromatosis. © bilderzwerg @ fotolia. Osteoarthritis (worn cartilage) is the most common joint condition. The most common form of osteoarthritis is osteoarthritis of the knee. Osteoarthritis of the knee causes chronic pain and limits movement. The cartilage in the knee wears away over many years. Since the cartilage has no sensitive nerve endings (pain sensors), damage is only noticed when the defects already affect the bone beneath the cartilage.. A cartilage transplant, or cartilage cell or chondrocyte transplant, is a new surgical procedure: in which ...
An enchondroma is a cartilage cyst found in the bone marrow. Typically, enchondroma is discovered on an X-ray scan. Enchondromas have a characteristic appearance on Magnetic Resonance Imaging (MRI) as well. They have also been reported to cause increased uptake on PET examination. Enchondroma is a type of benign bone tumor that originates from cartilage. The exact etiology of it is not known. An enchondroma most often affects the cartilage that lines the inside of the bones. The bones most often involved with this benign tumor are the miniature long bones of the hands and feet. It may, however, also involve other bones such as the femur, humerus, or tibia. While it may affect an individual at any age, it is most common in adulthood. The occurrence between males and females is equal. It is not very likely that the enchondroma will grow back in the same spot; the rate is less than ten percent. While the exact ...
Chordomas and chondrosarcomas are difficult to manage using conventional cancer treatment methods. Areas of the body frequently affected by this type of cancer include the spine, skull, pelvis, hip, and shoulder.. Effective treatment of these tumours using surgical resection is not usually achievable due to neurovascular involvement. As a result, recurrence of the tumour when surgery is used in isolation poses a significant risk for both chordomas and chondrosarcomas. Due to the low risk of metastasis and relative chemoresistance, the use of definitive radiotherapy or perioperative radiotherapy is very important in maintaining local control.. Previous research has shown proton therapy to be beneficial in treating these types of tumours. Using protons, health professionals are able to treat chordoma and chondrosarcoma with higher doses of radiation due to the increased accuracy of proton therapy.. A 2019 study published in the journal Cancer entitled: The ...
Wilson R, Norris EL, Brachvogel B, Angelucci C, Zivkovic S, Gordon L, Bernardo BC, Stermann J, Sekiguchi K, Gorman JJ, Bateman JF. Changes in the Chondrocyte and Extracellular Matrix Proteome during Post-natal Mouse Cartilage Development. Molecular and cellular proteomics (2011) PubMed ...
AbstractBackgroundDistinguishing a benign enchondroma from a low-grade chondrosarcoma is a common diagnostic challenge for orthopaedic oncologists. Low interrater agreement has been observed for the diagnosis of cartilaginous neoplasms among radiologists and pathologists, but, to our knowledge, no s
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BioAssay record AID 606382 submitted by ChEMBL: Biodistribution in Sprague-Dawley rat cartilage at 3.2 to 18.6 MBq, iv after 120 mins by micro PET analysis.
Twenty-eight patients with histologically confirmed chordomas (18) or chondrosarcomas (10) underwent Gamma Knife SRS either as primary or adjuvant treatment. Their ages ranged from 17 to 72 years (median 44 years). The most common presenting symptom was diplopia (26 patients, 93%). In two patients, SRS was the sole treatment. Twenty-six patients underwent between one and five additional surgical procedures. Two underwent an initial trans-sphenoidal biopsy. The average tumor volume was 9.8 cm3. The median dose to the tumor margin was 16 Gy. ...
Published papers: 1. K N Srikanth, J H Stilwell, S A Shahane, Modified matched ulnar resection for arthrosis of distal radioulnar joint in rheumatoid arthritis, Hand Surgery, 2006 Jul; 11(1-2): 15-9. PMID:17080523 2. K N Srikanth, M Chong, K Porter. Acute exertional compartment syndrome of superficial posterior compartment of the leg, Acta Orthopædica Belgica, 2006:Vol. 72 -4:507-510. 3. K N Srikanth, A Kulkarni, AM Davies, RJ Grimer, Clear cell chondrosarcoma in association with Neimann-pick disease, Sarcoma,March/June 2005;9(1/2):33-36.A Gadgil, R Dias, 4. K.N. Srikanth, Nutcracker Fracture of The Cuboid Associated With Metatarsal Dislocation And Its Treatment. The Internet Journal of Orthopedic Surgery. 2006. Volume 3 Number 1. 5. Effect of sodium hyaluronate on recovery after arthroscopic knee surgery-a RCT, S Anand, K N Srikanth,C Bamforth, K Buch, T Asumu, Journal of Knee Surgery 2015. ...
Hereditary multiple exostosis (HME) / Hereditäre Multiple Exostose, Multiple exostosis disease, Multiple cartilagenous exostoses, Multiple osteochondroma, Multiple cartilagenous exostosis, Diaphyseal aclasis, Endochondromatosis
MULLER, Daniel Curvello de Mendonça et al. Hemipelvectomy in the treatment of chondrosarcoma of the acetabulum dog. Cienc. Rural [online]. 2010, vol.40, n.5, pp.1218-1222. ISSN 1678-4596. http://dx.doi.org/10.1590/S0103-84782010000500036.. Hemipelvectomy is the removal of part of the pelvis and is indicated for the surgical treatment of malignant tumors. This study presents the case of a canine patient with recurrent chondrosarcoma, submitted to hemipelvectomy with limb amputation. The report aims to highlight the importance of surgery in the treatment of radial bone chondrosarcoma, addressing a viable and unconventional alternative for patients suffering from tumors in the pelvis, which against the extension of the lesion may be misdiagnosed as intractable cancer. After the partial hemipelvectomy with amputation of the limb the animal satisfactory returned to ambulation without difficulty in supporting or alteration in balance.. Keywords : neoplasm; pelvis; ...
Surgery may also be necessary to correct painful limb abnormalities that are caused by multiple osteochondromas. Surgery may be needed to cut and realign the bones that have become deformed, which is known as osteotomy.[2] If the legs are not equal in length, treatment may include a procedure to slow down the growth of the longer leg. Surgery may also be needed to correct the forearm deformity seen in this condition. Adults with this condition who have untreated forearm deformities usually do not have significant functional limitations.[1] Although rare, an osteochondroma can become cancerous (malignant), which usually takes the form of a low grade chondrosarcoma. This type of malignant tumor is unlikely to spread elsewhere in the body. Higher grades of ...
Pain is the usual presenting symptom; alternatively the tumour may be found incidentally on imaging. Signs are localise to the involved bone. Imaging appearances are difficult as most chondrosarcomas resemble benign chondroma. The most common features are of central lucency with expansion and thickening of the overlying cortex.. ...
: Hereditary multiple exostoses (HME) is a rare genetic disorder, which can be associated with severe complications that may significantly affect the health-related quality of life (HRQL). Our primary objective was to describe the baseline HRQL in HM
NIH Rare Diseases : 50 ollier disease is a skeletal disorder characterized by multiple enchondromas, which are noncancerous (benign) growths of cartilage that develop within the bones. these growths may lead to skeletal deformities, limb discrepancy, and fractures. the enchondromas primarily occur in the limb bones, especially the bones of the hands and feet. they tend to develop near the ends of the bones, where growth occurs. symptoms often appear in the first decade of life. the underlying cause of ollier disease is not fully understood. in many people, the condition can be attributed to somatic mutations in the idh1 or idh2 gene. the disease is not typically inherited. treatment is conservative in most cases, although surgery may be indicated in cases where complications (pathological fractures, growth defects, malignant transformation) arise. last updated: 12/12/2016 ...
Chondroid tumors are predominantly lesions of the axial skeleton but can infrequently have an extraskeletal origin. Primary intracranial chondrosarcomas constitute ,0.16% of all brain tumors, an overwhelming majority of which are skull base tumors (1, 2). They are thought to arise from undifferentiated cells from cartilaginous synchondroses (1-3, 6, 7). Much less common sites include the falx, choroid plexus, and convexity. The histogenesis at this site is uncertain but is thought to arise from the pluripotent cells of the meninges.. Primary chondrosarcomas can be classified as mesenchymal, myxoid, or classical based on their cytoarchitecture. In the series published by Korten et al (2), which included 15 case reports plus 177 cases from a review of the literature, no sex dominance was shown. Ages varied from 3 months to 76 years, with a mean age of 37 years. Considering the rarity of occurrence of intracranial ...
Ollier disease is a rare nonhereditary disorder characterized by cartilage cysts found in the bone marrow. It is also known as enchondromatosis.
Sarcoma is a peer-reviewed, Open Access journal dedicated to publishing papers covering all aspects of connective tissue oncology research. It brings together work from scientists and clinicians carrying out a broad range of research in this field, including the basic sciences, molecular biology and pathology and the clinical sciences of epidemiology, surgery, radiotherapy and chemotherapy. High-quality papers concerning the entire range of bone and soft tissue sarcomas in both adults and children, including Kaposis sarcoma, are published as well as preclinical and animal studies.
The anatomic junction of the neural and facial viscerocranium is termed the skull base (). This area is critically important because it supports the brain and allows all the neurovascular structures to either enter or exit the skull.Neoplasms may ori
TY - JOUR. T1 - Inhibitory effect of midazolam on MMP-9, MMP-1 and MMP-13 expression in PMA-stimulated human chondrocytes via recovery of NF-κB signaling. AU - Wang, Jen Jui. AU - Huan, Steven Kuan Hua. AU - Hsieh, Kuo Hsien. AU - Chou, Hsiu Chu. AU - Hsiao, George. AU - Jayakumar, Thanasekaran. AU - Sheu, Joen Rong. PY - 2013/4. Y1 - 2013/4. N2 - Introduction: Midazolam, a benzodiazepine, has a hypnotic effect and is widely used as an intravenous sedative. Past studies have clearly established that midazolam has beneficial effects in attenuating ischemia-reperfusion injury more than other currently used sedative drugs. However, the role of midazolam on chondroprotection via inhibition of matrix metalloproteinases (MMPs) is warrant investigation. The aim of this study was to examine the mechanisms of action of midazolam on MMP expression via nuclear factor κB (NF-κB) signaling in activated chondrosarcoma cells maintained in vitro. Material and methods: Chondrocytes, SW1353 ...
Case Reports in Otolaryngology is a peer-reviewed, Open Access journal that publishes case reports in all areas of otolaryngology, including head and neck surgery, facial plastic and reconstructive surgery, maxillofacial surgery, and pediatric otolaryngology.
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An adult male squirrel monkey with severe bilateral exophthalmia and conjunctivitis was euthanatized. Necropsy revealed, in a sagittal section of the head (Fig. 135), a gray-white mass involving the...
VS38c is a monoclonal antibody that recognises a rough endoplasmic reticulum (rER) intracellular antigen termed cytoskeleton-linking membrane protein 63. rER is typically found in viable tumour cells and is abundant in osteosarcoma cells. The aim of this study was to determine the diagnostic and prognostic utility of VS38c in the histological assessment of osteosarcoma and other bone tumours/tumour-like leisons.Immunohistochemical staining with VS38c was carried out on formalin-fixed specimens of osteosarcoma (pre/post-chemotherapy) and a wide range of benign and malignant bone lesions. In addition, VS38c staining of cultures of MG63 and Sa0S2 osteosarcoma cell cultures. (±cisplatin and actinomycin D-treatment) was analysed.VS38c strongly stained tumour cells in all low-grade and high-grade osteosarcomas and in undifferentiated sarcomas and high-grade chondrosarcomas. There was little or no VS38c staining of low-grade ...
Hereditary multiple exostoses a dominantly inherited hereditary disorder seen as a multiple cartilaginous tumors is certainly due to mutations PF-2545920 in associates from the gene family or and assays we present that EXT2 will not harbor significant glycosyltransferase activity in the lack of EXT1. in the growth bowl of endochondral bone tissue (1). This problem can result in skeletal abnormalities brief stature and occasionally malignant change from exostoses to chondrosarcomas (2 3 or osteosarcomas (4 5 Although hereditary linkage analysis provides discovered three different loci for HME on 8q24.1 on 11p11-13 and on 19p (6-8) most HME situations have been related to missense or frameshift mutations in either or (9-15). and encode 746- and 718-aa protein respectively that are PF-2545920 portrayed ubiquitously in individual tissue (9 16 Prior research using epitope-tagged constructs possess confirmed that EXT1 is certainly a mostly endoplasmic reticulum (ER)-localized glycoprotein whose ...
TBX3, a member of the T-box family of transcription factors, is essential in development and has emerged as an important player in the oncogenic process. TBX3 is overexpressed in several cancers and has been shown to contribute directly to tumour formation, migration and invasion. However, little is known about the molecular basis for its role in development and oncogenesis because there is a paucity of information regarding its target genes. The cyclin-dependent kinase inhibitor p21WAF1 plays a pivotal role in a myriad of processes including cell cycle arrest, senescence and apoptosis and here we provide a detailed mechanism to show that it is a direct and biologically relevant target of TBX3. Using a combination of luciferase reporter gene assays and in vitro and in vivo binding assays we show that TBX3 directly represses the p21WAF1 promoter by binding a T-element close to its initiator. Furthermore, we show that the TBX3 DNA binding domain is required for the ...
The importance of understanding how costal cartilage chondrocytes respond to stimuli such as oxidative stress and low pH has been largely overlooked in studies involving tissue culturing due to major differences between oxygen and pH levels during incubation and the natural environment of hyaline cartilage. Hyaline cartilage is avascular and naturally hypoxic which subsequently leads to increased glycolytic metabolism and ultimately causes a decrease in extracellular pH. To examine how healthy costal cartilage responds to these extreme growth conditions, we examined responses in three hyaline cartilage diseases. Our ability to identify the disease mechanisms responsible for pectus excavatum, pectus carinatum, and chondrosarcoma are limited by our understanding of how these mechanisms operate. This study aimed to determine ...
However, differential diagnosis may be problematic at early stages with other ossified lesions of soft tissues: benign lesions such as myositis ossificans circumscripta (MOC), ossifying lipoma, soft tissue osteoma or chondroma, and ossifying fibromyxoid tumour, as well as malignant lesions such as classical high-grade ESOS, parosteal OS, mesenchymal chondrosarcoma, and synovial sarcoma. MOC is a benign heterotopic ossification of soft tissues characteristically associated with direct trauma [15]. It is one of the most important differential diagnoses, which was initially evoked - based on radiological and/or pathological aspects - in at least 3 out of the 7 reported cases of low-grade ESOS. Furthermore, a number of cases of ESOS presumably arising from MOC have been reported [16-19]. In MOC, both mature and immature bone is seen, as well as a prominent spindle cell and chondroid component, with a specific architecture described as the "zonal phenomenon". This phenomenon ...
Purified proteoglycan subunits from human articular, bovine articular and nasal cartilages, and a rat chondrosarcoma were phosphorylated in vitro by beef heart cAMP-dependent protein kinase in the presence of gamma 32P-ATP. In these experiments, a maximum of 1.7 moles of 32P were incorporated per mole of proteoglycan from human cartilage. Phosphorylation was dependent on the presence of cAMP. Analysis by autoradiography revealed that serine residues in the core protein of the proteoglycan were the sites of phosphorylation. Treatment of proteoglycan subunits with chondroitinase ABC and alkaline phosphatase prior to reaction with cAMP-dependent protein kinase increased the incorporation of 32P by 12-30% when compared with untreated proteoglycans. These data indicate that proteoglycans in cartilage can be phosphorylated by cAMP-dependent protein kinase.
An enchondroma is a type of noncancerous bone tumor that begins in cartilage. An enchondroma most often affects the cartilage that lines the inside of the bones. It often affects the tiny long bones of the hands and feet. It may also affect other bones such as the femur (thighbone), humerus (upper arm bone), or tibia (one of the two lower leg bones).
The primary purpose of this study is to determine if the administration of a higher dose would decrease the chance of tumor recurrence, compared to the risk of tumor recurrence with a lower dose. Most of the treatment will be given protons, but participants may receive a small portion of treatment with x-rays, because less radiation is given to the skin with x-rays. This study uses two slightly different doses of radiation It is not clear at this time which of the dose levels is better ...
The primary purpose of this study is to determine if the administration of a higher dose would decrease the chance of tumor recurrence, compared to the risk of tumor recurrence with a lower dose. Most of the treatment will be given protons, but participants may receive a small portion of treatment with x-rays, because less radiation is given to the skin with x-rays. This study uses two slightly different doses of radiation It is not clear at this time which of the dose levels is better ...
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
LAUBSCHER, M; HELD, M e DUNN, RN. Primary bone tumours of the spine: Presentation, surgical treatment and outcome. SA orthop. j. [online]. 2015, vol.14, n.2, pp.22-28. ISSN 2309-8309. http://dx.doi.org/10.17159/2309-8309.. BACKGROUND: Primary bone tumours of the spine are a group of rare tumours that include both benign and malignant lesions. Resection is associated with a high morbidity rate. METHODS: We retrospectively reviewed all the primary bone tumours of the spine that were surgically treated at our unit between 2005 and 2012 (haematological malignancies were excluded. RESULTS: Fifteen cases were included that presented at a median age of 36 years (range 8 to 65 years). Pain was the most common presenting symptom. Three patients had significant neurological deficits at time of presentation and in two cases there was an improvement after surgery. The median delay in diagnosis was 7 months (range 1 to 36 months). A variety of surgical strategies was employed with the use of adjuvant radio- ...
Chordoma is a rare slow-growing neoplasm thought to arise from cellular remnants of the notochord. The evidence for this is the location of the tumors (along the neuraxis), the similar immunohistochemical staining patterns, and the demonstration that notochordal cells are preferentially left behind in the clivus and sacrococcygeal regions when the remainder of the notochord regresses during fetal life. There are three histological variants of chordoma: classical (or "conventional"), chondroid and dedifferentiated. The histological appearance of classical chordoma is of a lobulated tumor composed of groups of cells separated by fibrous septa. The cells have small round nuclei and abundant vacuolated cytoplasm, sometimes described as physaliferous (having bubbles or vacuoles). Chondroid chordomas histologically show features of both chordoma and chondrosarcoma. Chordomas can arise from bone in the skull base and anywhere along the spine. The ...
Radiographic findings of 15 untreated chondrosarcomas of the cranial and facial bones were reviewed. These tumors have a propensity to occur in the wall of a maxillary sinus, at the junction of sphenoid and ethmoid sinuses and vomer, and at the undersurface of the sphenoid bone. Because of its slow-growing nature, chondrosarcomas tend to be large, multilobulated, and sharply demarcated when detected. Frequent bone changes are a combination of erosion and destruction, with sharp transitional zones and absent periosteal reaction. Tumor matrix calcifications, not necessarily chondroid, are almost always present. Both CT and MR may be necessary for thorough evaluation of tumor extent. ...
Chondromas are benign tumours composed of mature hyaline cartilage. We present here the first case in the English language medical literature of juxtaarticular chondroma of the temporomandibular joint in the parotid region. Within the rarity of cartilage disorders of the temporo-mandibular joint (TMJ), this particular condition is a diagnostic curiosity. The patient, a 54 year old woman, presented a right preauricular tumour of 3.5 cm. which had been developing for 4 years. It was not painful but there was a recent symptomology of TMJ dysfunction, with pain and clicks. The diagnostic possibilities of a parotid pleomorphic adenoma and of a cartilage tumour of the TMJ suggested a difficult preoperative differential diagnosis, which influenced our approach regarding therapy. The tumour was excised, preserving the parotid gland. This enabled us to confirm the histological diagnosis of chondroma, composed solely ...
This two day European workshop is aimed at young researchers (post-docs, PhD, etc.) working on Bone Sarcoma/Sarcoma. The meeting aims to provide training in bone sarcoma and more specifically osteosarcoma, chondrosarcoma and Ewing sarcoma. Invited speaker presentations will be complemented by oral communications and poster presentations from attending delegates (priority given to young researchers).. ...
Figure 1 -- Multiple bony thoracic sessile & pedunculated osteochondromas. Note the abnormal dysplastic bones. The underlying inferior aspect of the posterior 6th rib ...
This type of cancer forms as a painful lump (tumour) in the bone. During a bone sarcomas growth stage, the cancer cells multiply and start to destroy the bone. This then causes the affected bone to become weak.. The most common places where bone sarcoma develops are around the knee, the wrist, the shoulder and the pelvis. They are mostly found in children, teenagers and young adults.. The most common type of bone cancer is osteosarcoma, which accounts for 5% of the tumours in children. This form of bone cancer is characterised by its millions of abnormal bone producing cells. Ewings sarcoma is another type of bone cancer, however this type of sarcoma can also occur as a soft tissue sarcoma, depending on the location of the tumour. Chondrosarcoma is also a bone sarcoma characterised by its millions of abnormal cartilage cells.. Symptoms of bone sarcomas depend on multiple ...
Although the clinical classification of Maffucci syndrome is well defined, physical manifestation of the disease is often heterogeneous. Symptoms are not present at birth but generally occur in early childhood with several pleiotropic phenotypes.3 Skeletal deformations associated with enchondromas are variable, affecting both long and flat bones,4 and malignant transformation to chondrosarcoma is common. Furthermore, a broad spectrum of other cellular dysplasias has been reported, including ovarian, pancreatic, parathyroid, and pituitary tumors.5-7 A recent study suggests a receptor mutation for the parathyroid hormone, and related proteins may play a role in the broad spectrum of associated phenotypes.8 However, another study failed to confirm this finding, suggesting that multiple mechanisms are involved in the pathogenesis.9 Similarly, vascular lesions, although easily identified by small blue subcutaneous nodules, may appear in various other sites. Large ...
The economic burden of bone cancers can be great. The more advanced the disease, the worse the prognosis and, accordingly, the more expensive the treatments. It is likely that early detection, and, certainly, prevention if possible, could drastically reduce costs. A number of expensive treatments are required to address these tumors. In the 2007 report by Damron, Ward, and Stewart,1 it was noted that the most frequent initial treatments varied widely based on the type of sarcoma. Although not reported, these treatments vary widely based on the stage of the disease as well.. Collectively, they reported that surgery alone was the most common initial treatment for chondrosarcomas (69%), whereas for Ewing sarcoma, treatments were divided between surgery and chemotherapy (24% of cases), radiation and chemotherapy (23%), and chemotherapy alone in 18%. With osteosarcoma, when initial treatment was known, the largest group received surgery and chemotherapy (46%). Surgery was reported as part of the ...
Cancer that appears in the bone in the form of tumors is considered bone cancer or bone sarcoma. The most common form of bone cancer is Osteosarcoma which often appear in the knees, upper legs, and upper arms. Other forms of bone sarcoma include Chondrosarcoma which affects the cartilage in pelvis, upper legs, and shoulders; Chordoma which affects from base of the skull, all along the spine; and Ewings Sarcoma which affects the bone marrow and bones.
Multiple exostoses is a condition in which people develop multiple abnormal bone growths on the surface of a pre-existing bone. The number and locations of the exostoses varies greatly among individuals with the condition. Affected individuals usually do not have exostoses at birth, but develop them by the time they are around twelve years of age. The growth of exostoses usually stops when an individual reaches physical maturity and the bones stop growing. Multiple exostoses can cause stunted growth, uneven limb lengths, and other skeletal abnormalities. They can often be painful and affect movement. Although exostoses are usually benign, they may become cancerous in some instances. Multiple exostoses may be treated by surgically removing the growths ...
Osteosarcoma, a primary bone cancer. The osteosarcoma is one of the primary cancers of the bone, that is to say developed from bone cells, cartilage or fibrous tissue, as opposed to secondary cancers of the bone metastases that are of cancer in another organ. The osteosarcoma is primary bone cancer the most common, before the chondrosarcoma, Ewings sarcoma and multiple myeloma . Of unknown cause, osteosarcoma usually occurs in children and young adults, between 10 and 25 years. The bones are usually affected long bones near the knee or shoulder: tibia, femur and humerus. We traditionally distinguish two forms of osteosarcoma: one attacks the central part of the bone (medullary bone), the other in the peripheral zone of the bone, destroying the periosteum, the membrane that surrounds the bone and is responsible for its growth in thickness. You should also remember that osteosarcoma can spread through the bloodstream and ...
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CLINICAL STAGING. Thoracic CT scans are recommended to assess for metastasis to the lungs, and this can be done at the same time as assessment of the primary rib tumor.. TREATMENT. Chest wall resection and reconstruction is recommended for dogs with rib tumors. Six, and may be more, ribs can be resected without adversely affecting ventilatory function. In one study of 39 dogs with rib tumors, the rib tumor was either adhered to or invaded into the lungs in 31% of dogs, the pericardium in 13% of dogs, and the diaphragm in 5% of dogs. In these cases, contiguous organs or structures should be excised en bloc with the rib tumor. The chest wall defect is reconstructed with muscle flaps, prosthetic mesh, or diaphragmatic advancement depending on the location and size of the defect. Chemotherapy is recommended for dogs with osteosarcoma, but not chondrosarcoma.. PROGNOSIS. Osteosarcoma. The prognosis for dogs with rib osteosarcoma is guarded. Local recurrence is uncommon (12%). Local tumor ...
Nine patients with enchondromas in the hand were treated by endoscopic curettage of the tumour without bone grafting. The procedure was performed on an out-patient basis using axillary block anaesthesia. New bone formation and remodelling of the lesi
Conditions: Soft Tissue Sarcoma; Bone Sarcoma; Chondrosarcoma; Gastrointestinal Stromal Sarcoma; Ewings Tumor Metastatic; Ewings Tumor Recurrent; Osteosarcoma; Desmoplastic Small Round Cell ...
Angiosarcoma, carcinosarcoma, chondrosarcoma, clear cell, dermatofibrosarcoma protuberans, epithelioid, ewings, gastrointestinal stromal tumor, hemangiopericytoma, histiocytic, leiomyosarcoma, liposarcoma, malignant fibrous histiocytoma, myxofibrosarcoma, osteosarcoma, primitive neuro-echtodermal, rhabdomyosarcoma, sarcoma, soft tissue, synovial, undifferentiated pleomorphic, Wilms Tumor This is an open group, members can apply to join.. ...
Looking for online definition of Ollier's layer in the Medical Dictionary? Ollier's layer explanation free. What is Ollier's layer? Meaning of Ollier's layer medical term. What does Ollier's layer mean?
BACKGROUND: We analyzed our experience in sternal resections (SRs) for primary or secondary neoplasm focusing on technical aspects of reconstruction, post-operative outcomes and long term survival. METHODS: From January 2005 to December 2015, 36 patients (24 males, 67%) underwent surgical excision of primary (chondrosarcoma n=18 patients, 50%; osteosarcoma n=2, 6%; Ewing sarcoma n=1, 3%; other n=2, 6%) or secondary (breast cancer n=7, 19%; kidney carcinoma n=2, 6%) sternal tumour. We performed n=30 partial sternectomy and n=6 total sternectomy with en-bloc resection of the sternocostal cartilages in all patient and extended resection in 7 patients. Stability was obtained with prosthetic material, rigid and non-rigid and a muscular flap: rigid material [Strasbourg Thoracic Osteosynthesis System (STRATOS), MedXpert GmbH] and muscle flap n=11 (30.6%); polytetrafluoroethylene patch and muscle flap n=6 (16.7%); muscle flap alone n=19 (52.8%). ...
Osteochondromas are the rare benign and malignant tumour of the growing bone, usually affecting the young adults. Solitary osteocartilaginous exostosis is more common than the hereditary multiple exostosis (HME). The first 3 decades of life has maximum chances of getting affected with osteochondroma and hardly occurs in craniofacial bones because of the fact that these bones are not formed by endochondral ossification. Most of the symptoms occur at the periphery of the bone tissues, with causes of osteochondroma being unknown. It involves in genetic condition and is associated with mutations of EXT1 or EXT2 genes. Diagnosis is difficult at symptomless stage, incidentally it is diagnosed when X-ray is carried out. Detection of tumor by ultra sound is accurate than other diagnosis process. No treatment is required other than regular monitoring of tumor. Standard allele specific PCR based techniques on osteochondroma showing both recombine and intact alleles were reported. The observation shows ...
A combination of computed tomography (CT) and magnetic resonance imaging (MRI) is now established as the optimum assessment of sinonasal malignancy. CT and MRI are of particular value in assessing the skull base, orbit and pteryo-palatine and infratemporal fossae. Although MRI offers better differentiation of tumour from surrounding tissue and fluid, coronal CT is still required for the demonstration of bone erosion particularly in the region of the cribriform plate. Thus the extent of local tumour spread may be determined with a degree of accuracy in excess of 98 per cent. However, the final determinant of penetration of the dura and orbital periosteum requires per-operative frozen section assessment. A knowledge of the tissue characteristics and site of origin can be of value in distinguishing some of the commoner sinonasal malignancies such as squamous cell carcinoma, adenocarcinoma, adenoid cystic carcinoma, olfactory neuroblastoma and chondrosarcoma. Imaging, ...
The search for evidence to support the growing use of proton therapy for more cancers continues to uncover valuable findings. New data from clinical trials demonstrate the potential advantages of proton therapy over conventional radiation for pancreatic cancer, late-stage non-small cell lung cancer, chordoma, and chondrosarcoma.
Our specialists see patients with all sarcomas and a variety of mesenchymal tumors, including chondrosarcoma, desmoid tumor, liposarcoma, neurofibrosarcoma, osteosarcoma, and rhabdomyosarcoma. Our group is also dedicated to clinical research to develop innovative treatment strategies for soft tissue and bone malignancies.
Ongoing Research Support. P20GM104937 Chen (PI) 09/15/12-08/31/17. Center of Biomedical Research Excellence in Skeletal Health and Repair. The goal of this project is to establish a multi-disciplinary research center to treat cartilage joint diseases.. Role: PI. R01 AR 059142-01A1 Wei (PI) 04/01/11-01/31/16 Histone Deacetylation Regulates Growth Plate Development. The goal of this project is to understand how HDAC4 regulates growth plate development by CaMKIV, P38 MAPK, and miR-1.. Role: Co-Investigator. R01CA166089-01A1 Terek (PI) 09/25/13-07/31/18. Targeting CXCR4 and microRNA as Therapy. The goal of this project is to develop therapy to treat chondrosarcoma.. Role: Co-Investigator. R01AR066746-01A1 Yang (PI) 09/01/15-08/30/20. The goal of this project is to study how the property of cartilage stem cells is regulated by the protein tyrosine phosphatase SHP2 under physiological and pathological conditions. ...
White jw a case series reporting unacceptably high rates of revision arthroscopic rotator cuff tears. The the temporal bone. A claviculectomy is also not routinely indicated. , the axilla. The part of a posterior communicating arteries left supraorbital posterior cerebral arteries internal carotid artery head and glenoid labrum. The patient went on to the contralateral shoulder instability often observed as a hip joint mechanics, and low - grade, chondrosarcoma arising out of the congenital undescended scapula. Shows a large overlap and are not painful, figure. This ensures that the patient is placed in the development of humeral metastases analysis of cases. Intracervical apophyseal joints is often followed by progressive superior migration of leukocytes of the distal clavicle excision. Stimson h traumatic rupture of the capsule all the supercial infraclavicular triangle formed by layers of blood arriving from the lateral approach will meet that challenge. If one nutrients, ...
ThinPrep (TP) and TriPath PREP (TriP) are two liquid-based cytologic preparations that produce a thin layer of cells. This study compares the diagnostic accuracy and different cytomorphologic alterations produced by these preparations in nongynecologic specimens. Samples from 10 urines (3 urothelial carcinomas and 7 negative), 4 positive serous fluids, and 7 fine-needle aspirates (FNAs) were prepared by both techniques. FNAs represented one each of: Hashimotos thyroiditis (HT), hyperplastic colloid nodule (HCN), Hodgkins lymphoma, liposarcoma, chondrosarcoma, squamous-cell carcinoma (SCC) metastatic to the lymph node, and carcinoid tumor. All 5 participants, none of whom had prior knowledge of the clinical history or histologic diagnosis, reviewed and interpreted the slides. Both techniques produced a clean background and were equally accurate in urines, serous fluids, and three FNAs. TriP was slightly more accurate in four FNAs: HCN and HT where colloid and lymphocytes were ...
Autosomal dominant disorder characterized by cone-shaped Epiphyses in the hands and Multiple Cartilaginous Exostoses. Intellectual Disability and abnormalities of Chromosome 8 are often present. The Exostoses in this Syndrome appear identical to those of Hereditary Multiple Exostoses (Exostoses, Hereditary Multiple ...
HISTORY S.G. is a 12 year old BF who presented with a chief complaint of left knee pain on the medial aspect of the proximal tibia. The pain was described as a dull, aching pain present for one years time, occassionally awakening her from sleep and occassionally worsening with sports activities. Her past medical history was essentially unremarkable. There was a questionable family history for bony tumors. PHYSICAL EXAMINATION Physical examination revealed full range of motion of all her extremities. She was neurovascularly intact. DTRs were normal and symmetric. Palpation at the left knee revealed an asymptomatic mass at the distal femur medially and a painful protrusion at the medial proximal tibia. XRAYS X-rays of her left knee in the AP/lat/oblique views revealed multiple exostoses of the distal femur and proximal tibia. These were also noted in bilateral forearm films at the proximal and distal poles ...
As for Genehunter1s query... Aspergillie is again right on. We gave up on commercial so-called primary chondrocyte lines early on, because they lost their phenotype quickly. Some people also use various chondrosarcomas for matrix studies too, usually in the context of protein production for structural biology, but you dont want to read too much into normal cartilage biology from these cell types. Weve found that isolating our own from weanling rat rib/costal cartilage works best for our studies. This (Bone. 1988;9(3):185-94) is a GREAT paper describing this method in detail especially regarding ECM characteristics. We can maintain growth cells in monloayer for about 15 passages before they get weird. The phenotypic shift is quite dramatic...they become spindly rather than their normal rounded/cuboid morphology and they just suddenly stop proliferating at the usual pace of a 36-48h doubling time to a week or ...
Looking for online definition of chondroid in the Medical Dictionary? chondroid explanation free. What is chondroid? Meaning of chondroid medical term. What does chondroid mean?
Cardiovasc. 4. Persistent pleural effusion causes dullness on percussion and postural hypotension and flank painif bladder involved. 2. Slow, reddish oozing or heavy bleeding, iv access for excision of the gallbladder, and ulcerative colitis and crohn disease. Myoclonicbrief involuntary muscle contractions of one or more negative viral diagnostic tests may be restricted while hospitalized based on income level and the cutaneous roots of adjacent tissue are known and organism is identified. 2018, ). New york: Elsevier. 5. Perform a more severe and is well regulated other drugs: Optic agents such as runs of atrial fibrillation, cardiomyopathy, valvular heart disease, congestive heart failure, hypotension, ventricular ectopy (because of inhalation injury 1. Maintain neurologic flow sheet; identify emerging trends in treatment. Chondrosarcomas can occur through the aorta. (2012). 3. Patient may complain of pain and tenderness; may mimic mittelschmerz, pid, appendicitis, or ...
Primary extraskeletal osteosarcoma (ESOS) presenting in thoracic locations is very rare and associated with a poor prognosis. The current study presents a case involving a large anterior mediastinal mass, which was histologically confirmed as a primary osteosarcoma. The literature concerning primary …
Hereditary multiple exostoses (EXT; MIM 133700) is an autosomal dominant bone disorder. It is genetically heterogeneous with at least three chromosomal loci: EXT1 on 8q24.1, EXT2 on 11p11, and EXT3 on 19p. EXT1 and EXT2, the two genes responsible for EXT1 and EXT2, respectively, have been cloned. Recently, three other members of the EXT gene family, named the EXT-like genes (EXTL: EXTL1, EXTL2, and EXTL3), have been isolated. EXT1, EXT2, and the three EXTLs are homologous with one another. We have identified the intron-exon boundaries of EXTL1 and EXTL3 and analyzed EXT1, EXT2, EXTL1, and EXTL3, in 36 Chinese families with EXT, to identify underlying disease-related mutations in the Chinese population. Of the 36 families, five and 12 family groups have mutations in EXT1 and EXT2, respectively. No disease-related mutation has been found in either EXTL1 or EXTL2, although one polymorphism has been detected in EXTL1. Of the 15 different mutations (three families share a common mutation in EXT2), 12 ...
Looking for Chondroma? Find out information about Chondroma. A benign tumor of bone, cartilage, or other tissue which simulates the structure of cartilage in its growth. a benign tumor of mature cartilage tissue.... Explanation of Chondroma
Osteosarcomas are the most common primary malignant bone tumor that occurs in children and adolescents, and they frequently occur around the knee. In the past, amputation or joint disarticulation was the standard of care. Currently, more than 90% of osteosarcoma resections are limb-sparing procedures because of advancements in chemotherapeutic regimens and three-dimensional imaging studies, including CT and MRI. In addition, joint-sparing surgery is possible in select patients. To preserve the joint structure for good limb function in patients with osteosarcoma, we have been performing epiphyseal or metaphyseal osteotomy and biologic reconstruction via frozen autograft treated with liquid nitrogen. Several advantages are expected with the use of the freezing technique. This strategy involves simple surgical technique without specialized devices. A perfect fit is achieved because the managed bone is the patients own and bone strength is maintained postoperatively. Satisfactory bone union and
Osteosarcoma is the most common primary malignant bone tumor that most frequently affects young adults. There is increasing evidence that miRNAs (miRs) are important modulators of gene expression and their deregulation has been reported in various human tumors. This study investigated differences in miR expression in normal human osteoblast cells versus malignant human osteosarcoma cells differ in their miR expression. Analysis of miRNA expression in normal osteoblast cell lines (hOBc, NHOST, hFOB) and osteosarcoma cell lines (KHOS, Saos, U-2OS) were completed using miR microarray technology with unsupervised hierarchical clustering analysis. The relative expression levels of these miRs were confirmed by real-time quantitative RT-PCR. A number of miRs were found to have different expression in the osteosarcoma cells when compared to normal human osteoblasts. Three miRs, miR-199a-3p, miR-127-3p and miR-376c were significantly decreased in osteosarcoma cell ...
Osteosarcoma is a rare neoplasm that develops in bone tissue. Our osteosarcoma patients receive efficient, coordinated treatment from a multidisciplinary team of specialists that include pediatric ...
Osteosarcoma (OS) is the most common, non-hematopoietic, primary malignant bone tumor. OS is characterized by its aggressive local growth and systemic dissemination. Although combination of surgical operation and adjuvant chemotherapy greatly improved the prognosis, more than 20% of patients still cannot get long-term survival. Therefore, novel therapeutic approaches should be expected to be developed. Previously, we developed an OS mouse model by overexpressing c-MYC in bone marrow stromal cells derived from Ink4a/Arf knockout mice. We isolated highly tumorigenic cells (designated AXT cells) from tumors after serial transplantation. Inoculation of AXT cells into syngeneic C57BL/6 mice results in the development of lethal OS with metastatic lesions including lung, which pathologically and clinically mimics human osteoblastic osteosarcoma. To obtain the novel therapeutic agents for OS, we performed drug screening using ...
Exhibit Distinct MiRNA Expression Profiles. Background: Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Despite aggressive treatment around 40% of patients still die of their disease, which may be due to the heterogeneous nature of the tumor. Previously in our lab, we were able to identify and isolate tumorigenic and non-tumorigenic cells within the same tumor based on their ability to activate an exogenous Oct-4/GFP human promoter. Oct-4/GFP positive fraction probed to be at least 100-fold more tumorigenic than Oct-4/GFP negative fraction. The global transcription profile of these two populations revealed G2/M, spindle assembly checkpoint override and proliferation pathways more active in GFP positive cells. Stress induced differentiation and reversion pathways were more active in Oct-4/GFP negative cells.There are several molecular mechanisms controlling the expression of genes. One important level of ...
Cancer involving bones of cats is rare. An estimate of the incidence of all bone tumors in cats is 4.9 per 100,000. Anywhere between 67% to 90% of bone tumors in cats are histologically malignant, and tumors occur in long bones approximately twice as often as in axial skeleton sites. The hind limbs are affected nearly twice as often as the front limbs. Osteosarcomas account for 70% to 80% of all primary malignant cancer of cats. The disease in cats differs from that in dogs in that the primary lesions occur more often in hind limbs in cats, and the disease is far less metastatic than in dogs. Osteosarcoma generally affects older cats (mean 10.2 years), but the age range of reported cases is large (1-20 years). In one study, males outnumbered females, but the opposite was found in a second study. Osteosarcoma was reported to arise after a limb fracture was repaired with an intramedullary pin in one cat. A case of suspected radiation-induced osteosarcoma has been reported in a cat.. Multiple ...
Bone sarcomas are primary bone tumors, which means that they start in the bones. They are usually found in children. Osteosarcoma, the most common type of primary bone cancer, usually occurs in the thigh, upper arm or shin.
Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma, Ewing sarcoma and...
Acta Neurochir (2017) 159:1835-1845. Chordoma is a rare bony malignancy known to have a high rate of local recurrence after surgery. The best treatment paradigm is still being evaluated. We report our experience and review the literature. We emphasize on the difference between endoscopic and open craniotomy in regard to the anatomical compartment harboring the tumor, the limitations of the approaches and the rate of surgical resection.. Method: We retrospectively collected all patients with skullbase chordomas operated on between 2004 and 2014. Detailed radiological description of the compartments being occupied by the tumor and the degree of surgical resection is discussed.. Results: Eighteen patients were operated on in our facility for skull-base chordoma. Seventeen endoscopic surgeries were done in 15 patients, and 7 craniotomies were done in 5 patients. The mean age was 48.9 years (±19.8 years). When reviewing the anatomical compartments, we found that the most common were the upper clivus ...
The high rate of multicentric gliomas, the identification of IDH mutations in all of the gliomas in which it could be fully assessed and the identical IDH mutations found in both the glioma and the skeletal tumor of two patients strongly suggest that, in most cases, similar to cartilaginous tumors, the development of gliomas in enchondromatosis patients results from somatic IDH mosaicism. The very rare IDH1 R132H and ATRX positive cells with a normal morphology found in patient 3 may further support this hypothesis. Consistent with the demonstration of occasional IDH mutated cells in the normal bone, blood and bone marrow of some enchondromatosis patients, we speculate that these cells may correspond to normal glial cells with IDH mutations [3, 36]. However, this observation must be taken with caution since morphology is subjective and ATRX expression can be heterogeneous [41].. IDH mutations are considered to be the earliest oncogenic ...
Operative schema for total en bloc spondylectomy.(A) Pediculotomy using a T-saw and en bloc resection of the posterior element; (B) Anterior column osteotomy an
... Association AMETIST a pour mission daider les enfants ayant un cancer et daider leur famille dans cette preuve. Son but est galement de sauvegarder le service du docteur nicole del pine traitant les ost osarcomes et autres tumeurs osseuses
Harsh, G.; Ojemann, R.; Varvares, M.; Swearingen, B.; Cheney, M.; Joseph, M., 2006: Pedicled rhinotomy for clival chordomas invaginating the brainstem
Glucosamine stimulates the cartilage cells to produce the needed proteoglycans, large molecules that give cartilage strength and resilience, allowing it to stretch and then resume its normal form as the joints moves. A deficiency of glucosamine will result in low levels of proteoglycans that are inadequate in maintaining healthy joints. Glucosamine is one of the main ingredients of the synovial fluid that lubricates and provides nutrients for the joint structures. This synovial fluid reduces friction in the joints allowing for effortless motion. It not only lubricates the joints but it also acts as a comfortable shock absorber. Furthermore, glucosamine inhibits several enzymes whose job is the break down of old proteoglycan molecules nearing the end of their normal life span. In summary, glucosamine not only stimulates the production of cartilage but it can also improve ...
Learn about Carticel (Autologous Cultured Chondrocytes for Implantation) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.

Tumors and Tumorlike Lesions of Bone - Fritz Schajowicz - Häftad (9783642499562) | BokusTumors and Tumorlike Lesions of Bone - Fritz Schajowicz - Häftad (9783642499562) | Bokus

Mesenchymal Chondrosarcoma.- 4. Clear-Cell Chondrosarcoma.- III Giant-Cell Tumor (Osteoclastoma).- Giant-Cell Tumor in Paget ... II Cartilage-Forming Tumors.- A. Benign.- 1. Chondroma.- 2. Osteochondroma (Osteocartilaginous Exostosis).- 3. Chondroblastoma ... Giant-Cell (Reparative) Granuloma (Giant-Cell Reaction).- X Current Concepts of Treatment of Bone Tumors.- 1. Giant-Cell Tumor ... Murali Sundaram.- The Role of Pathology.- Classification of Bone Tumors.- I Bone-Forming Tumors.- A. Benign.- 1. Osteoma.- 2. ...
more infohttps://www.bokus.com/bok/9783642499562/tumors-and-tumorlike-lesions-of-bone/

Chondrosarcoma facts, information, pictures | Encyclopedia.com articles about ChondrosarcomaChondrosarcoma facts, information, pictures | Encyclopedia.com articles about Chondrosarcoma

Make research projects and school reports about Chondrosarcoma easy with credible articles from our FREE, online encyclopedia ... mesenchymal chondrosarcoma, and dedifferentiated chondrosarcoma. Clear cell chondrosarcoma is the most rare form of ... Chondrosarcomas arise from chondroblasts, cells that form cartilage. Cartilage is the matrix found at the tip of the nose and ... chondrosarcoma (kon-droh-sar-koh-ma) n. (pl. chondrosarcomata) an uncommon malignant tumour of cartilage cells occurring in a ...
more infohttp://www.encyclopedia.com/medicine/diseases-and-conditions/pathology/chondrosarcoma

Chondrosarcoma - Foot and Ankle | BONETUMOR.ORGChondrosarcoma - Foot and Ankle | BONETUMOR.ORG

Clear cell chondrosarcoma has clear cells with vacuolated cytoplasm. The cartilage matrix has significantly calcified ... This tumor has several subtypes, including clear cell chondrosarcoma, and mesenchymal chondrosarcoma, which can occur in bone ... Dedifferentiated chondrosarcoma is the most malignant form of chondrosarcoma. This tumor is a mix of low grade chondrosarcoma ... Clear cell chondrosarcoma is a malignant cartilage tumor that may be the adult variant of chondroblastoma. It is a rare, low- ...
more infohttps://bonetumor.org/tumors-foot-and-ankle/chondrosarcoma-foot-and-ankle

Bone SarcomasBone Sarcomas

... rare form of chondrosarcoma is a deadly high grade sarcoma consisting of primitive mesenchymal cells and islands of cartilage ... Clear Cell Chondrosarcoma. Clear Cell Chondrosarcoma is a destructive low-grade malignant tumor which presents in adults. Clear ... any cells from which connective tissue is developed in the body. These cells form scars as well as perform other important ... Periosteal Chondrosarcoma. Periosteal chondroma is a rare benign surface lesion composed of cartilage. It is similar in ...
more infohttps://www.reininsarcoma.org/what-is-sarcoma-2/bone-sarcomas/

Soft Tissue Sarcoma | Vanderbilt-Ingram Cancer CenterSoft Tissue Sarcoma | Vanderbilt-Ingram Cancer Center

Bone and Cartilage Tumors. Extraskeletal mesenchymal chondrosarcoma. Treatment of extraskeletal mesenchymal chondrosarcoma may ... Tumors of unknown cell origin. Tumors of unknown cell origin (the type of cell the tumor first formed in is not known) include ... Bone and cartilage tumors. Bone and cartilage tumors are a mix of bone cells and cartilage cells. Bone and cartilage tumors ... Extraskeletal mesenchymal chondrosarcoma . This type of bone and cartilage tumor often affects young adults and occurs in the ...
more infohttps://www.vicc.org/cancer-info/childhood-soft-tissue-sarcoma

Childhood Soft Tissue Sarcoma Treatment (PDQ®): Treatment - Patient Information [NCI] - North Kansas City Hospital, Kansas City...Childhood Soft Tissue Sarcoma Treatment (PDQ®): Treatment - Patient Information [NCI] - North Kansas City Hospital, Kansas City...

A mix of bone and cartilage. Fibrous tissue. Muscles. Nerves. Tendons (bands of... ... cells form in soft tissues of the body. Soft tissues of the body connect, support, and surround other body parts and organs. ... Bone and cartilage tumors include the following types:. *Extraskeletal mesenchymal chondrosarcoma. This type of bone and ... Desmoplastic small round cell tumor. This tumor most often forms in the abdomen, pelvis or tissues around the testes, but it ...
more infohttp://www.nkch.org/patients-visitors/health-library/healthwise-document-viewer/?id=ncicdr0000258672

Type II & III Pathology Diagnosis and Differential Diagnosis - The International Pleuropulmonary Blastoma RegistryType II & III Pathology Diagnosis and Differential Diagnosis - The International Pleuropulmonary Blastoma Registry

Cartilaginous differentiation, either in the form of chondroid matrix or well-formed islands of hyaline cartilage, is found in ... Anaplastic cells are not found in the blastematous or chondroid foci, but rather in the uncommitted mesenchymal foci or, less ... The nodules of cartilage, when present, have a degree of cellularity and atypia to qualify as chondrosarcoma in most cases. In ... Focal cellular anaplasia in the form of giant, bizarre-appearing pleomorphic cells with irregular hyperchromatic nuclei is ...
more infohttps://www.ppbregistry.org/health-professionals/pathology/type-ii-and-iii-pathology-diagnosis-and-differential-diagnosis

Diagnostic Pathology: Bone. Edition No. 2 - Research and MarketsDiagnostic Pathology: Bone. Edition No. 2 - Research and Markets

19 Conventional Chondrosarcoma. 20 Dedifferentiated Chondrosarcoma. 21 Clear Cell Chondrosarcoma. 22 Mesenchymal Chondrosarcoma ... Benign Bone-Forming Tumors 1 Bone Island/Osteopoikilosis. 2 Osteoma. 3 Osteoid Osteoma. 4 Osteoblastoma. Malignant Bone-Forming ... Benign Cartilage Tumors 11 Vascular Cartilaginous Hamartoma of Chest Wall. 12 Osteochondroma. 13 Multiple Hereditary ... 34 Benign Notochordal Cell Tumor. 35 Chordoma. Giant Cell-Rich Tumors 36 Giant Cell Tumor. 37 Brown Tumor. 38 Giant Cell ...
more infohttps://www.researchandmarkets.com/reports/3773981/diagnostic-pathology-bone-edition-no-2

Chondrosarcoma: Practice Essentials, Background, PathophysiologyChondrosarcoma: Practice Essentials, Background, Pathophysiology

Chondrosarcoma is a collective term for a group of tumors that consist predominantly of cartilage and that range from low-grade ... Chondrosarcoma is a tumor of mesenchymal origin that predominantly is made of cartilage; it is the second most common primary ... Clear cell chondrosarcoma. Although clear cell chondrosarcomas are low-grade tumors, they can lead to distant metastasis. Late ... Tumors with the aforementioned elements (ie, the presence of bone-forming elements and primitive mesenchymal elements in ...
more infohttps://emedicine.medscape.com/article/1258236-overview

Diagnostic Radiology/Musculoskeletal Imaging/Tumors Advanced - Wikibooks, open books for an open worldDiagnostic Radiology/Musculoskeletal Imaging/Tumors Advanced - Wikibooks, open books for an open world

6. Bone and cartilage forming a. Fibro-osseous pseudotumor of the digit 7. Miscellaneous a. Myxoma b. Alveolar soft part ... 1. Cartilaginous a. Mesenchymal chondrosarcoma 2. Osseous a. High grade surface osteosarcoma 3. Fibrous and fibrohistiocytic a ... 5. Peripheral nerve a. Plexiform neurofibroma b. Granular cell tumor c. Clear cell sarcoma d. Extraskeletal Ewing sarcoma i. ... Round cell iiii. Pleomorphic iiiii. Dedifferentiated 2. Vascular and lymphatic a. Glomus tumor b. Hemangiopericytoma c. ...
more infohttps://en.wikibooks.org/wiki/Diagnostic_Radiology/Musculoskeletal_Imaging/Tumors_Advanced

Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways | DevelopmentSox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways | Development

... osteoclasts and hematopoietic cells then invade and form primary ossification centers (Lefebvre and Smits, 2005). Cartilage at ... A possible explanation for the rapid death of SW1353 cells is that these chondrosarcoma cells undergo rapid cell cycles, such ... most chondroprogenitor cells are arrested as condensed mesenchymal cells, whereas a few cells differentiate into chondrocytes ... Apoptosis of SW1353 chondrosarcoma cells by SOX9 knockdown and Akt phosphorylation in SW1353 cells and mice. (A) Immunoblot ...
more infohttps://dev.biologists.org/content/138/8/1507.long

Hepatoblastoma en el adultoHepatoblastoma en el adulto

In the mixed hepatoblastomas (epithelial and mesenchymal) -45 % of AHB-, osteoid and cartilage tissue can be identified showing ... The microscopic study confirmed the AHB diagnosis, revealing the presence of epithelial cells forming clusters, trabecular ... chondrosarcoma, angiosarcoma and rhabdomyosarcoma features have been described (1,10). ... Microscopic description: epithelial tumor composed by epithelial cells forming nets and tubular structures, and trabeculae as ...
more infohttp://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082013000400009

Tumor Surgery > Tumor Education > Bone Tumors > General...Tumor Surgery > Tumor Education > Bone Tumors > General...

... the mesenchymal cells that form a sarcoma can grow along a specific pathway and form tissue that looks like bone, cartilage, ... A patient can have a malignant bone tumor that produces cartilage. This is called a chondrosarcoma (chondro means cartilage). ... They are derived from cells that look like epithelial cells or glandular cells. These cells do not form bone, muscle, nerve, ... mesenchymal cells in the body form the bones, muscles, cartilage, connective tissue, blood vessels, blood cells, and nerves. ...
more infohttp://tumorsurgery.org/tumor-education/bone-tumors/general-information.aspx

Case Reports - Reviews sub-cluster 54Case Reports - Reviews sub-cluster 54

In this paper we report the 1st case of a congenital intracranial mesenchymal chondrosarcoma in a 2-month-old infant, ... while microscopy revealed a mixture of undifferentiated small cells and mature hyaline cartilage islands, positive for vimentin ... Lymphoplasmacytic sclerosing pancreatitis forming a localized mass: a variant form of autoimmune ... ... Congenital intracranial mesenchymal chondrosarcoma: case report and review of the literature in ... ...
more infohttp://www.biomedsearch.com/cluster/53/Case-Reports-Reviews/sub-54-p5.html

NAD Synthesis Pathway Interference Is a Viable Therapeutic Strategy for Chondrosarcoma | Molecular Cancer ResearchNAD Synthesis Pathway Interference Is a Viable Therapeutic Strategy for Chondrosarcoma | Molecular Cancer Research

... this tumor cell line is most likely derived from a dedifferentiated chondrosarcoma (14). MCS170 (mesenchymal chondrosarcoma; ... Chondrosarcoma represents a heterogeneous group of cartilage-forming tumors. It is the second most common primary bone ... Chondrosarcoma cell lines are sensitive for NAD+ depletion. A, Eleven chondrosarcoma cell lines and a chondrocyte cell line ... all chondrosarcoma cell lines showed dose-dependent decreases in cell viability and 8 of 11 chondrosarcoma cell lines showed ...
more infohttps://mcr.aacrjournals.org/content/15/12/1714

Fibrosarcoma: Diagnosis, Treatment, Research and SupportFibrosarcoma: Diagnosis, Treatment, Research and Support

Sarcomas are spindle cell malignancies of mesenchymal cell origin and are named and classified after the predominant cell line ... whereas chondrosarcoma neoplasms make abundant cartilage. In contrast, fibrosarcomas produces neither bone nor cartilage. ... Fiber-forming tumors and tumor-like lesions of bone fall into one of two categories: benign or malignant. Benign conditions ... Derivatives of mesenchymal cells, fibroblasts are found throughout the body and are the cells primarily responsible for ...
more infohttp://sarcomahelp.org/fibrosarcoma.html

Chondrosarcoma Research Study: IDH1 and IGH2 Mutations in Cartilage TumorsChondrosarcoma Research Study: IDH1 and IGH2 Mutations in Cartilage Tumors

... causing enchondroma and chondrosarcoma and was funded by the Liddy Shriver Sarcoma Initiative. ... This chondrosarcoma research study aimed to identify the gene(s) ... Four cell lines derived from solitary central chondrosarcomas ... Chondrosarcoma is the second most frequent malignant bone tumor that forms cartilage. Adults in the third to sixth decade are ... Adults in the third to sixth decade are affected (1). Chondrosarcoma is unique amongst mesenchymal tumours since it has benign ...
more infohttp://sarcomahelp.org/chondrosarcoma-research.html

Chondrosarcoma | Article about Chondrosarcoma by The Free DictionaryChondrosarcoma | Article about Chondrosarcoma by The Free Dictionary

Find out information about Chondrosarcoma. A malignant tumor of cartilage. a malignant tumor of cartilage tissue, sometimes ... ADAMTS12 depletion by insulin in OUMS-27 human chondrosarcoma cells. Chondrosarcoma is a malignant mesenchymal tumor that ... Bethany Priest and George Blakemore who has Stage 2 Chondrosarcoma, a rare form of bone cancer which has spread to his lungs. ... Related to Chondrosarcoma: osteosarcoma, mesenchymal chondrosarcoma. chondrosarcoma. [¦kän·drō·sär′kō·mə] (medicine) A ...
more infohttps://encyclopedia2.thefreedictionary.com/Chondrosarcoma

Sarcoma | definition of sarcoma by Medical dictionarySarcoma | definition of sarcoma by Medical dictionary

A malignancy of mesenchymal tissues-e.g., bone (osteosarcoma), cartilage (chondrosarcoma), fat (liposarcoma), fibrous tissue ( ... giant cell sarcoma a malignant form of giant cell tumor of bone. ... 2. Non-mesenchymal and malignant, most commonly spindle cell ... Oncology A CA of mesenchymal tissues-eg, bone-osteosarcoma, cartilage-chondrosarcoma, fat-liposarcoma, fibrous tissue- ... chondrosarcoma in cartilage; rhabdosarcoma in muscle; and liposarcoma in fat cells. adj., adj sarco´matous. ...
more infohttps://medical-dictionary.thefreedictionary.com/sarcoma

XXI - Musculoskeletal System Flashcards by Kathryn Reunilla | BrainscapeXXI - Musculoskeletal System Flashcards by Kathryn Reunilla | Brainscape

Identify the bone cell: most numerous than any other bone forming cell ... They exhibit malignant hyaline and myxoid cartilage. Conventional chondrosarcomas (TOPNOTCH)Robbins Basic Pathology,8th ed., ... A bone-producing malignant mesenchymal tumor, characterized as gritty, gray-white tumors, often exhibiting hemorrhage and ... Morphology: histological hallmark is the dual line of differentiation of tumor cells, epithelial like cells and spindle cells ...
more infohttps://www.brainscape.com/flashcards/xxi-musculoskeletal-system-2357110/packs/4171963

XXI - Musculoskeletal System Flashcards by Kate Ng | BrainscapeXXI - Musculoskeletal System Flashcards by Kate Ng | Brainscape

... multinucleated giant cells and a background of mononuclear cells (D) malignant mesenchymal cells with osteoid formation ... forming a pannus that destroys the underlying cartilage. ... Myxoid chondrosarcomas(TOPNOTCH)Robbins Basic Pathology,8th ed ... Identify the bone cell: most numerous than any other bone forming cell ... Morphology: histological hallmark is the dual line of differentiation of tumor cells, epithelial like cells and spindle cells ...
more infohttps://www.brainscape.com/flashcards/xxi-musculoskeletal-system-3875813/packs/5716662

Pulmonary Sarcomatous Tumors - RedorbitPulmonary Sarcomatous Tumors - Redorbit

These pure forms are extremely rare. A tumor consisting of a poorly differentiated squamous cell carcinoma, adenocarcinoma, or ... and a primitive mesenchymal stroma that occasionally has foci of osteosarcoma, chondrosarcoma, or rhabdomyosarcoma. This tumor ... cartilage, or striated muscle, have been described in many primary organ sites, including the lung. The classification of these ... Tumors that are composed exclusively of spindle cells or giant cells are termed spindle cell carcinoma and giant cell carcinoma ...
more infohttp://www.redorbit.com/news/health/1480009/pulmonary_sarcomatous_tumors/

Chondrosarcoma - MyPathologyReport.caChondrosarcoma - MyPathologyReport.ca

Chondrosarcomas can start within a bone or any other part of the body where cartilage is normally including the nose and ears. ... Chondrosarcoma is a cancer made up of cartilage. It is a type of cancer called a sarcoma. ... clear cell chondrosarcoma is always a grade 1 (low grade) tumour. In contrast, mesenchymal and dedifferentiated chondrosarcomas ... Cartilage is found throughout the body although most cartilage is found between bones where it helps form a cushion that ...
more infohttps://www.mypathologyreport.ca/chondrosarcoma/

A Rare and Interesting Case of a Massive Secondary Spinal Chondrosarcoma and Review of the LiteratureA Rare and Interesting Case of a Massive Secondary Spinal Chondrosarcoma and Review of the Literature

Chondrosarcoma, the second most common primary malignancy of the bone, is malignant cartilage forming tumour that very rarely ... Spinal chondrosarcoma usually belongs to a mesenchymal or clear cell histological subtype. However, our patient displayed a low ... Chondrosarcomas are a heterogeneous group of tumours, composed entirely of hyaline cartilage matrix and chondrocytes and range ... W. Hsu, E. McCarthy, Z. L. Gokaslan, and J.-P. Wolinsky, "Clear-cell chondrosarcoma of the lumbar spine: case report and review ...
more infohttps://www.hindawi.com/journals/crior/2015/386482/

Biology of Bone Sarcomas and New Therapeutic Developments | Springer for Research & DevelopmentBiology of Bone Sarcomas and New Therapeutic Developments | Springer for Research & Development

Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. ... Ewing sarcoma and chondrosarcoma [2, 3, 4]. Mesenchymal stem cells (MSCs) located in most of the tissues have the ability to ... Chondrosarcoma can form benign lesions in which the Hedgehog signalling pathway (such as EXT1 and EXT2 involved in the ... differentiate into various mesenchymal tissues including bone and cartilage [5]. Bone marrow and the bone environment are ...
more infohttps://rd.springer.com/article/10.1007/s00223-017-0372-2
  • The far most prevalent subtype (72% of the cases) is conventional central chondrosarcoma, in which the tumor arises centrally in the medulla of the bone. (aacrjournals.org)
  • It is cancer which arises from the cervix, it happens due to the abnormal growth of cells that possess the ability to spread and infecting the different parts of the body organs, some of the symptoms of cervical cancer that may include in this are vaginal bleeding, pelvic pain or pain during the sexual intercourse. (healthlove.in)
  • It arises from red marrow due to monoclonal proliferation of plasma cells and manifests in a wide range of radiographic abnormalities. (radiopaedia.org)
  • Under a microscope, the cells appear round and contain spindle cell elements and neoplastic cartilage formation. (encyclopedia.com)
  • When the specimen is predominantly cystic, Type II PPB is differentiated from Type I PPB by thickened or plaque-like areas composed of an overgrowth of rhabdomyosarcomatous, spindle cell sarcomatous, or blastematous elements. (ppbregistry.org)
  • Intranodal palisaded myofibroblastoma (IPM) also called as intranodal hemorrhagic spindle cell tumor with amianthoid fibers is a distinctive and rare mesenchymal neoplasm of lymph nodes. (biomedsearch.com)
  • Sarcomas are spindle cell malignancies of mesenchymal cell origin and are named and classified after the predominant cell line that is present. (sarcomahelp.org)
  • In particular, a spindle cell lesion of the lung in a woman should always prompt an inquiry into gynecologic history. (redorbit.com)
  • Therefore, tumor behavior and results of advanced diagnostic imaging are often used in conjunction with histopathologic findings to help distinguish a low-grade chondrosarcoma from a chondroma. (umn.edu)
  • Degenerative fraying and underlying cartilage abnormalities can often mimic tears of the labrum on conventional MRI. (duke.edu)
  • Enchondromas are common, benign, and usually asymptomatic hyaline cartilage forming neoplasms in the metaphyses and diaphyses of the short and long tubular bones of the limbs, especially the hands and feet [ 1 , 2 ]. (pubmedcentralcanada.ca)
  • On plain radiographs, chondrosarcoma of the long bones is a fusiform, lucent defect with scalloping of the inner cortex and periosteal reaction. (bonetumor.org)
  • Cartilage is found throughout the body although most cartilage is found between bones where it helps form a cushion that protects the ends of the bones from damage. (mypathologyreport.ca)
  • A key role for FGF signaling was made apparent by the discovery that gain of function mutations within FGF receptor 3 (FGFR3) * cause several forms of human dwarfism including achondroplasia, hypochondroplasia, and thanathophoric dysplasia, which are all characterized by the reduced growth of long bones ( Ornitz and Marie, 2002 ). (rupress.org)
  • Osteosarcomas can form where these bones are growing the fastest in children and adolescents, which is called the growth plate. (rarediseases.org)
  • This mesenchymal tumor usually affects the epiphyseal region or apophysis of the long bones particularly the femur and humerus. (biomedcentral.com)
  • Chondrosarcoma patients, especially those of high histologic grade with lower expression and hypermethylation of NAPRT, may benefit from inhibition of the NAD synthesis pathway. (aacrjournals.org)
  • citation needed] Testing of this pathway has indicated that the Wnt/β-Catenin increases β-Catenin levels before the activation of the Runx2 and Osx transcription factors which seems to suggest that early β-Catenin levels can be a sign of whether an early mesenchymal progenitor cell will progress to a chondrocyte or to an osteoblast. (wikipedia.org)
  • Our results indicated that PGE 2 enhances the migration of chondrosarcoma cells by increasing α2β1 integrin expression through the EP1/PLC/PKCα/c-Src/NF-κB signal transduction pathway. (biomedcentral.com)
  • For right now, my understanding of chondrosarcoma is very limited and I also realize that many websites on the internet has said that the exact genetics or pathway mechanism on how chondrosarcoma develops is not well understood. (naturalheightgrowth.com)
  • Right now I can't see or connect how learning more about chondrosarcoma will help lead to possible height increase since not even the medical professionals have figured even one pathway mechanism yet. (naturalheightgrowth.com)
  • Given the role of the Wnt pathway in cell fate and in the development of breast cancer, we hypothesized that defects in this pathway may contribute to the development of metaplastic carcinomas. (aacrjournals.org)
  • When the Wnt signaling pathway is activated, β-catenin translocates from the membrane and accumulates in the nucleus where it interacts with members of the lymphoid enhancer factor/T-cell factor family of transcriptional activators as a critical intermediate in signal transduction pathways. (aacrjournals.org)
  • Performing a truly representative biopsy of a chondrosarcoma is challenging because the lesion is composed of areas that carry different histologic grades. (medscape.com)
  • A chondrosarcoma is first suspected when an x-ray is taken and it shows a suspicious lesion in the area of the patient's complaint. (limbpreservation.org)
  • Skip metastases are found in high grade sarcomas, where tumor embolizes via marrow sinusoids, forming a lesion that is discontinuous from the primary tumor, but in the same bone. (aapmr.org)
  • During endochondral bone formation, Sox9 expression starts in mesenchymal progenitors, continues in the round and flat chondrocyte stages at high levels, and ceases just prior to the hypertrophic chondrocyte stage. (biologists.org)
  • Inactivation of Sox9 in the last few cell layers resulted in the absence of Col10a1 expression, suggesting that continued expression of Sox9 just prior to hypertrophy is necessary for chondrocyte hypertrophy. (biologists.org)
  • Signaling molecules regulating chondrocyte activities in growth cartilage may thus also be involved in OA pathogenesis. (biomedcentral.com)
  • The Gordon Research Seminar on Cartilage Biology and Pathology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. (grc.org)
  • The primary focus of this student run and organized meeting is to bring together young investigators from a variety of geographic and scientific backgrounds to further our understand of cartilage biology from the perspective of development, normal physiology, and pathology. (grc.org)
  • Over recent years, the link between cartilage/bone development and cartilage pathology has been reinforced by numerous groups. (grc.org)
  • This GRS will be held in conjunction with the "Cartilage Biology and Pathology" Gordon Research Conference (GRC). (grc.org)
  • The paper " Pathology in Practice ," outlines a case of chondrosarcoma in a 12-year-old, male, boston terrier. (umn.edu)
  • For many years, it has been appreciated that, during in vitro cultivation, glioblastoma cells can express a variety of heterogeneous markers, including multiple mesenchymal markers, and were generally thought to be due to mesenchymal drift or cultures are overgrown by mesenchymal cells from the abnormal vascular proliferations of the original glioma ( 10 , 11 ). (aacrjournals.org)
  • Our results revealed that CMSs form a heterogeneous group, therefore, immunohistochemical examinations could support differential and final diagnosis. (biomedcentral.com)
  • Depending on the type and location of the chondrosarcoma, the tumor can either be high grade and aggressive or low grade and not as invasive. (encyclopedia.com)
  • however, higher mitotic indices may be evident with more aggressive forms. (umn.edu)
  • Overall, he has remained unimpaired and in good condition despite his aggressive form of cancer. (worldwidescience.org)
  • a cytogenetic and DNA flow cytometric analysis of chondrosarcoma subtypes. (thefreedictionary.com)
  • Some authors have described subtypes that resemble those seen in dogs: chondroblastic, fibroblastic, and telangiectatic, as well as the giant cell variant. (maxshouse.com)
  • Furthermore, these studies indicated that cancer cells express multiple subtypes of the PGE receptor and that each subtype might be linked to different actions of PGE 2 . (biomedcentral.com)
  • For the dog of the present report, a diagnosis of chondrosarcoma was suspected from the cytologic findings for the fine-needle aspirate specimens, and was confirmed during histologic examination of sections of the hard palate mass. (umn.edu)