A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ B with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the BRONCHI.
A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ A with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the URINARY BLADDER and UTERUS.
A class of cell surface receptors for tachykinins that prefers neurokinin A; (NKA, substance K, neurokinin alpha, neuromedin L), neuropeptide K; (NPK); or neuropeptide gamma over other tachykinins. Neurokinin-2 (NK-2) receptors have been cloned and are similar to other G-protein coupled receptors.
A class of cell surface receptors for TACHYKININS with a preference for SUBSTANCE P. Neurokinin-1 (NK-1) receptors have been cloned and are members of the G protein coupled receptor superfamily. They are found on many cell types including central and peripheral neurons, smooth muscle cells, acinar cells, endothelial cells, fibroblasts, and immune cells.
A family of biologically active peptides sharing a common conserved C-terminal sequence, -Phe-X-Gly-Leu-Met-NH2, where X is either an aromatic or a branched aliphatic amino acid. Members of this family have been found in mammals, amphibians, and mollusks. Tachykinins have diverse pharmacological actions in the central nervous system and the cardiovascular, genitourinary, respiratory, and gastrointestinal systems, as well as in glandular tissues. This diversity of activity is due to the existence of three or more subtypes of tachykinin receptors.
A class of cell surface receptors for tachykinins that prefers neurokinin B (neurokinin beta, neuromedin K) over other tachykinins. Neurokinin-3 (NK-3) receptors have been cloned and are members of the G-protein coupled receptor superfamily. They have been found in the central nervous system and in peripheral tissues.
An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.
Cell surface proteins that bind TACHYKININS with high affinity and trigger intracellular changes influencing the behavior of cells. Three classes of tachykinin receptors have been characterized, the NK-1; NK-2; and NK-3; which prefer, respectively, SUBSTANCE P; NEUROKININ A; and NEUROKININ B.
Compounds that inhibit or block the activity of NEUROKININ-1 RECEPTORS.
Cell surface receptors that bind signalling molecules released by neurons and convert these signals into intracellular changes influencing the behavior of cells. Neurotransmitter is used here in its most general sense, including not only messengers that act to regulate ion channels, but also those which act on second messenger systems and those which may act at a distance from their release sites. Included are receptors for neuromodulators, neuroregulators, neuromediators, and neurohumors, whether or not located at synapses.
Intercellular signaling peptides that were originally characterized by their ability to suppress NEOPLASM METASTASIS. Kisspeptins have since been found to play an important role in the neuroendocrine regulation of REPRODUCTION.
A peptide extracted from the posterior salivary glands of certain small octopi (Eledone spp., Mollusca), or obtained by synthesis. Its actions resemble those of SUBSTANCE P; it is a potent vasodilator and increases capillary permeability. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1364)
Benzopyrroles with the nitrogen at the number two carbon, in contrast to INDOLES which have the nitrogen adjacent to the six-membered ring.
An oligopeptide isolated from the skin of Physalaemus fuscumaculatus, a South American frog. It is a typical kinin, resembling SUBSTANCE P in structure and action and has been proposed as a sialagogue, antihypertensive, and vasodilator.
An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.
A family of hexahydropyridines.
A nucleus located in the middle hypothalamus in the most ventral part of the third ventricle near the entrance of the infundibular recess. Its small cells are in close contact with the ependyma.
Compounds that specifically inhibit PHOSPHODIESTERASE 5.
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.
Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
A tubular duct that conveys TEARS from the LACRIMAL GLAND to the nose.
An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.
The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
Inflammation caused by an injurious stimulus of peripheral neurons and resulting in release of neuropeptides which affect vascular permeability and help initiate proinflammatory and immune reactions at the site of injury.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.
A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Use of electric potential or currents to elicit biological responses.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).
Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).
Neurons in the SPINAL CORD DORSAL HORN whose cell bodies and processes are confined entirely to the CENTRAL NERVOUS SYSTEM. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to ANTERIOR HORN CELLS or to the WHITE MATTER ascending and descending longitudinal fibers.
The flattened, funnel-shaped expansion connecting the URETER to the KIDNEY CALICES.
A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.
Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).
Part of the brain located in the MEDULLA OBLONGATA and PONS. It receives neural, chemical and hormonal signals, and controls the rate and depth of respiratory movements of the DIAPHRAGM and other respiratory muscles.
The use of animals as investigational subjects.
The lower portion of the BRAIN STEM. It is inferior to the PONS and anterior to the CEREBELLUM. Medulla oblongata serves as a relay station between the brain and the spinal cord, and contains centers for regulating respiratory, vasomotor, cardiac, and reflex activities.
Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor". The Journal ... C alpha activation mediate arachidonic acid mobilization by the human NK-2 receptor expressed in Chinese hamster ovary cells". ... This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A.[5] ... Gerard NP, Eddy RL, Shows TB, Gerard C (Jan 1991). "The human neurokinin A (substance K) receptor. Molecular cloning of the ...
2004). "Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1". J. ... Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor". J. Biol. ... 2003). "Neurokinin B peptide serum levels are higher in normotensive pregnant women than in preeclamptic pregnant women". Am. J ... 2003). "Neurokinin B is a paracrine vasodilator in the human fetal placental circulation". J. Clin. Endocrinol. Metab. 88 (5): ...
"Neurokinin-1 receptors located in human retinoblastoma cell lines: antitumor action of its antagonist, L-732,138". ... Bang R, Sass G, Kiemer AK, Vollmar AM, Neuhuber WL, Tiegs G (April 2003). "Neurokinin-1 receptor antagonists CP-96,345 and L- ... Rittner HL, Lux C, Labuz D, Mousa SA, Schäfer M, Stein C, Brack A (December 2007). "Neurokinin-1 receptor antagonists inhibit ... Yu J, Allison S, Ibrahim D, Cadet JL, Angulo JA (June 2002). "Ontogeny of neurokinin-1 receptor mediation of methamphetamine ...
Its receptor - the neurokinin type 1 - is distributed over cytoplasmic membranes of many cell types (neurons, glia, endothelia ... Other neurokinin subtypes and neurokinin receptors that interact with SP have been reported as well. Amino acid residues that ... Substance P has been known to stimulate cell growth in normal and cancer cell line cultures, and it was shown that substance P ... "Hepatoblastoma cells express truncated neurokinin-1 receptor and can be growth inhibited by aprepitant in vitro and in vivo". ...
Chemotherapy interferes with cell division, which particularly affects rapidly dividing cells like those of the ... In the final common pathway, substance P, which activates the neurokinin-1 receptor, appears to be involved. Additionally, the ... It is now widely known that cytotoxic chemotherapeutic agents cause enterochromaffin cells to produce more serotonin in ... 2004). "Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant". Biological ...
Natural killer cells misinterpret the fetal cells as cancer cells and attack them. An individual that presents with ... For this purpose, it uses several mechanisms: It secretes Neurokinin B containing phosphocholine molecules. This is the same ... These phospholipids are essential in the aiding the cells of the fetus to remain attached to the cells of the uterus with ... Also, there is presence of small lymphocytic suppressor cells in the fetus that inhibit maternal cytotoxic T cells by ...
There is presence of small lymphocytic suppressor cells in the fetus that inhibit maternal cytotoxic T cells by inhibiting the ... For this purpose, the placenta uses several mechanisms: It secretes Neurokinin B-containing phosphocholine molecules. This is ... About 20,000 protein coding genes are expressed in human cells and 70% of these genes are expressed in the normal mature ... Williams Z, Zepf D, Longtine J, Anchan R, Broadman B, Missmer SA, Hornstein MD (March 2008). "Foreign fetal cells persist in ...
Cell-penetrating peptide is a peptide able to penetrate the cell membrane. Acetyl hexapeptide-3 Beefy meaty peptide Collagen ... Magainin family Cecropin family Cathelicidin family Defensin family Substance P Kassinin Neurokinin A Eledoisin Neurokinin B ... All of these peptides are synthesized by cells as longer "propeptides" or "proproteins" and truncated prior to exiting the cell ...
... of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells". ...
... innate immune cells, including immature dendritic cells (DCs), natural killer (NK) cells, and T cells, as well as (5) their ... Other peptides include cGRP, galanin, somatostatin, and neurokinin A-B. The biological effects of SP are expressed by the ... B cells and T cells are the major lymphocytes involved. A variety of cytokines have been observed in the pulp. Patients with ... Dendritic cells (DCs) are a heterogeneous leukocyte (white blood cell) population. DCs in healthy peripheral tissues (steady ...
Its receptor - the neurokinin type 1 - is distributed over cytoplasmic and nuclear membranes of many cell types (neurons, glia ... Substance P has been known to stimulate cell growth in normal and cancer cell line cultures,[37] and it was shown that ... "Hepatoblastoma cells express truncated neurokinin-1 receptor and can be growth inhibited by aprepitant in vitro and in vivo". ... on cells (including cancer cells) bestowing upon them mobility.[40] and metastasis.[41] It has been suggested that cancer ...
Neurokinin-1 receptors located in human retinoblastoma cell lines: antitumor action of its antagonist, L-732,138". ... Noailles, PA; Angulo, JA (2002). „Neurokinin receptors modulate the neurochemical actions of cocaine". Annals of the New York ... Bang, R; Sass, G; Kiemer, AK; Vollmar, AM; Neuhuber, WL; Tiegs, G (2003). „Neurokinin-1 receptor antagonists CP-96,345 and L- ... Rittner, HL; Lux, C; Labuz, D; Mousa, SA; Schäfer, M; Stein, C; Brack, A (2007). „Neurokinin-1 receptor antagonists inhibit the ...
Kisspeptin, neurokinin B, and dynorphin (KNDy) neurons are neurons in the hypothalamus of the brain that are central to the ... Moore, Aleisha M; Coolen, Lique M; Porter, Danielle T; Goodman, Robert L; Lehman, Michael N (2018-07-11). "KNDy Cells Revisited ... KNDy neurons in the hypothalamus coexpress kisspeptin, neurokinin B (NKB) and dynorphin. They are involved in the negative ... KNDy neurons control GnRH pulse generation by through release of three known peptides: neurokinin B (NKB), dynorphin and ...
... neurokinin-1, and cholecystokinin-1 receptors. Various local mediators located in enterochromaffin cells of the gut mucosa play ... material released by body or cancer cells into the blood can be detected directly in the area postrema of the brain and trigger ... a neurokinin-1 antagonist) given before chemotherapy. A common consequence of cancer treatment is the development of ...
"Entrez Gene: TAC1 tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha ... These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They ... Neurokinin A can also be further modified to produce neuropeptide K (also known as neurokinin K) and neuropeptide gamma. ... In cow brains, PPT-1 primarily encodes substance P, but not other neurokinin A-derived peptides. GRCh38: Ensembl release 89: ...
The main target cells of LH are the Leydig cells of testes and the theca cells of the ovaries. LH secretion changes more ... A study discovered that a mutation in genes encoding both neurokinin B as well as the neurokinin B receptor can alter the ... The main target cells of FSH are the ovarian follicles and the Sertoli cells and spermatogenic tissue of the testes. ... Much of the testosterone moves into nearby cells called granulosa cells. Smaller increases of FSH induce an increase in the ...
neuronal cell body membrane. • cell nucleus. • sperm midpiece. Biological process. • response to estradiol. • aging. • ... Neurokinin B - endogenous peptide ligand, also interacts with other neurokinin receptors but has highest affinity for NK3 ... This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.[6] ... Khawaja AM, Rogers DF (Jul 1996). "Tachykinins: receptor to effector". The International Journal of Biochemistry & Cell Biology ...
Cell. Biol. 18 (10): 5880-7. doi:10.1128/mcb.18.10.5880. PMC 109174. PMID 9742105. Zhang F, Lin M, Abidi P, Thiel G, Liu J ( ... giving rise to substance P and neurokinin A and the choline acetyltransferase responsible for the biosynthesis of the important ... Cell. 4 (5): 735-43. doi:10.1016/s1097-2765(00)80384-6. PMID 10619021. Liu YW, Tseng HP, Chen LC, Chen BK, Chang WC (July 2003 ... Cell. Biol. 23 (12): 4066-82. doi:10.1128/mcb.23.12.4066-4082.2003. PMC 156132. PMID 12773552. Mo X, Kowenz-Leutz E, Xu H, ...
The kisspeptin, neurokinin B, and dynorphin cell groups are found to be co-localized to more than 95% of all of the ... The main receptor neurokinin B interacts with is the neurokinin 3 receptor (NK3R). The Neurokinin 3 receptor is a part of a ... Neurokinin b is expressed along with the peptides kisspeptin and dynorphin A in the neuronal cells of the arcuate nucleus. Five ... A review of neurokinin B and its sister peptides, kisspeptin and dynorphin, in sheep found that these KNDy cell groups ( ...
... has an inhibitory effect on the formation of myeloid cells, and appear to be involved in one specific receptor ... Neurokinin A was shown to be a potent chemo attractor for T-cells increasing the migration into infected tissues. This ... 2008 Sep;295(3):C679-91 Like Substance P [SP], Neurokinin A is present in excitatory neurons and secretory cells of the ... Inflammation, tissue healing and cell proliferation have been linked to both SP and neurokinin A release into surrounding ...
Therefore, this class of molecules has both a cell-cell adhesion role and a cell-surface receptor role, in axon navigation. ... Wei X-Y, Zhao Y, Wong-Riley MTT, Ju G and Liu Y-Y (2012). Synaptic relationship between somatostatin- and neurokinin-1 receptor ... Cadherin domains take part in homophilic cell-cell adhesion. Classical cadherins are characterized by a conserved catenin- ... It is the cell bodies of the follower neurons that follow the axons of the pioneer neurons, instead of what it was thought ...
"A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain". Cell. 178 (6): 1362-1374.e16. doi: ... neurokinin A (NKA), and endothelin-3 (ET-3). In such neurons, release of these pro-inflammatory mediators is thought to be ... Once released, these neuropeptides induce the release of histamine from adjacent mast cells. In turn, histamine evokes the ... 10.1016/j.cell.2019.07.014. ISSN 1097-4172. PMC 6731142. PMID 31447178. Zhao, Jianhua; King, John V. Lin; Cheng, Yifan; Julius ...
Finally, GPNMB expression in breast cancer cells is capable of promoting cell migration, invasion, and metastasis both in vitro ... "Hematopoietic growth factor inducible neurokinin-1 type: a transmembrane protein that is similar to neurokinin 1 interacts with ... dendritic cells, and it is overexpressed in various cancer types. In melanocytic cells and osteoclasts the GPNMB gene is ... relevance to cell cycle regulation". Cell Cycle. 4 (2): 315-22. doi:10.4161/cc.4.2.1468. PMID 15684612. Haralanova-Ilieva B, ...
"Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of novel ... Receptors,+Neurokinin-1 at the US National Library of Medicine Medical Subject Headings (MeSH) Overview of all the structural ... The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein ... Fong TM, Yu H, Huang RR, Strader CD (December 1992). "The extracellular domain of the neurokinin-1 receptor is required for ...
Other cell populations include: A small population of neurons that sensitive to ghrelin. The role of this population is not ... These neurons express estrogen receptors and also coexpress neurokinin B in female rats. GHRH neurons help to control growth ... These cells are important in the regulation of appetite, and, when activated, they inhibit feeding. These neurons are activated ... The arcuate nucleus also contains a population of specialized ependymal cells, called tanycytes. Astrocytes in the arcuate ...
1997). „Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of ... Receptors,+Neurokinin-1 на US National Library of Medicine Medical Subject Headings (MeSH) ... Jordan, K (2006). „Neurokinin-1-receptor antagonists: a new approach in antiemetic therapy". Onkologie. 29 (1-2): 39-43. PMID ... Ho, Z W.., Douglas S. D. (decembar 2004). „Substance P and neurokinin-1 receptor modulation of HIV". Journal of Neuroimmunology ...
Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor". J. Biol. ... 2003). "Ocular TFF-peptides: new mucus-associated secretory products of conjunctival goblet cells". Adv. Exp. Med. Biol. ... Bhogal N, Donnelly D, Findlay JB (1994). "The ligand binding site of the neurokinin 2 receptor. ...
Microglia, the brain and spinal cord resident immune cells, respond to extrinsic cues. The source of these cues may include ... Molecules such as substance P may be involved in potentiation via neurokinin receptors. NMDA activation also triggers a change ... The inciting cause of neuropathy has important consequences for its mechanistic basis as different tissues and cells are ... Rr, Ji; A, Chamessian; Yq, Zhang (2016-11-04). "Pain Regulation by Non-Neuronal Cells and Inflammation". Science. 354 (6312): ...
Like the others of this class, the α1 subunit forms the pore through which calcium enters the cell and determines most of the ... Meza U, Thapliyal A, Bannister RA, Adams BA (January 2007). "Neurokinin 1 receptors trigger overlapping stimulation and ... Cell Physiology. 292 (1): C573-80. doi:10.1152/ajpcell.00219.2006. PMID 16855219. Catterall WA, Perez-Reyes E, Snutch TP, ... They are poorly understood, but like Q-type calcium channels, they appear to be present in cerebellar granule cells. They have ...
... neurokinin A - neurokinin K - neurokinin-1 receptor - neurokinin-2 receptor - neuron - neuronal cell adhesion molecule - ... cell - cell adhesion molecule - Cell biology - cell cycle protein - cell membrane - cell membrane transport - cell nucleus - ... T cell - T-cell antigen receptors - tachykinin - tachykinin receptor - talin protein - tandem repeat sequence - taste bud - ... Hela cell - helminth protein - helper T cell - hemopexin - hemoglobin - herpes simplex virus protein vmw65 - heterocyclic ...
Cell 176, 459-467 (2019). doi: 10.1016/j.cell.2018.12.011 NIHMSID: 1516560 S. Chen, M. Lu, D. Liu, L. yang, C. Ui, L. Ma, H. ... the human neurokinin 1 receptor, and the melatonin receptors MT1 and MT2 2020:The human melanocortin 4 receptor (MC4) , , In ... Cell 172, 719-730 (2018). Online 01Feb2018. DOI: 10.1016/j.cell.2018.01.001. PMC6309861, 364. Z. Yang, S. Han, M. Keller, A. ... Crystal structure of human lysophosphatidic acid receptor 1 Cell 161: 1633-1643 H. Zhang, H. Unal, C. Gati, G.W. Han, W. Liu, N ...
Many neuronal cells are unresponsive to stimulation by IL-6 alone, but differentiation and survival of neuronal cells can be ... May 2013). "Full central neurokinin-1 receptor blockade is required for efficacy in depression: evidence from orvepitant ... It supports the growth of B cells and is antagonistic to regulatory T cells. It is capable of crossing the blood-brain barrier ... IL-6 was seen to have roles in tumor microenvironment regulation, production of breast cancer stem cell-like cells, metastasis ...
"Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type ... "MicroRNAs may mediate the down-regulation of neurokinin-1 receptor in chronic bladder pain syndrome". The American Journal of ... "MTA1 gene silencing inhibits invasion and alters the microRNA expression profile of human lung cancer cells". Oncology Reports ...
In the gut, 5-HT is found mostly in mucosal enterochromaffin cells. Enterochromaffin cells are sensory transducers that release ... on responses to injection of a neurokinin agonist into the ventral tegmental area of the rat brain". Eur. J. Pharmacol. 138 (2 ... Serotonin is released by the enterochromaffin cells of the small intestine in response to chemotherapeutic agents and may ... disorders that cause vomiting have been found to cause release of large amounts of serotonin from enterochromaffin cells in the ...
... also called Oligodendrocyte progenitor cell) cells. Type 2: Antigenically A2B5+, GFAP+, FGFR3−, Ran 2−. These cells can develop ... and neurokinin 1 receptor (NK1R), as well as activation of metabotropic glutamate receptors and release of BDNF. Persistent ... Müller cells of the retina and Bergmann glia cells of the cerebellar cortex represent an exception, being present still during ... Astrocytes are a sub-type of glial cells in the central nervous system. They are also known as astrocytic glial cells. Star- ...
... s in the dorsal raphe nucleus are co-localized with neurokinin 1 (NK1) receptors and have been shown to inhibit ... 5-HT1A receptors can be located on the cell body, dendrites, axons, and both presynaptically and postsynaptically in nerve ... April 2007). "Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function". European ... Journal of Cell Science. 125 (Pt 10): 2486-99. doi:10.1242/jcs.101337. PMID 22357950. S2CID 970339. Salim K, Fenton T, Bacha J ...
Not only is PHY closely related to Substance P (SP), but it also has a higher affinity for the mammalian neurokinin receptors ... Cell Biochemistry and Biophysics. 64 (1): 29-44. doi:10.1007/s12013-012-9364-z. ISSN 1085-9195. v t e. ... This helical conformation is essential to allow the binding of PHY to neurokinin-1 (NK1) receptors. Consensus sequences between ...
... and digestive processes Cell density sensing: A novel GPCR role in regulating cell density sensing. Homeostasis modulation (e.g ... neurokinin, thyrotropin-releasing hormone [​TRH​], and oxytocin); and endocannabinoids. GPCRs that act as receptors for stimuli ... Cell. 172 (1-2): 41-54.e19. doi:10.1016/j.cell.2017.11.033. PMC 5766829. PMID 29249361. Royal Swedish Academy of Sciences (10 ... Protein kinase A is an important enzyme in cell metabolism due to its ability to regulate cell metabolism by phosphorylating ...
Neuropeptides found in the basal ganglia include substance P, neurokinin A, cholecystokinin, neurotensin, neurokinin B, ... During development, the cells that migrate tangentially to form the basal ganglia are directed by the lateral and medial ... Since the great majority of caudate cells fire at very low rates, this activity almost always shows up as an increase in firing ... Movement disorders include, most notably Parkinson's disease, which involves degeneration of the dopamine-producing cells in ...
More therapies are being developed to target the more discreet modulators of the HPG axis including kisspeptin and neurokinin B ... Huang AW, Muneyyirci-Delale O (July 2017). "Reproductive endocrine issues in men with sickle cell anemia". Andrology. 5 (4): ... Chronic conditions such as sickle cell disease and thalassemia, cystic fibrosis, HIV/AIDS, hypothyroidism, chronic kidney ... Aeddula NR, Baradhi KM (2018), "Sickle Cell Nephropathy", StatPearls, StatPearls Publishing, PMID 30252273, retrieved 2019-01- ...
In the mid 1980s, the additional mammalian tachykinin neurokinin A (NKA) and neurokinin B (NKB) were discovered. This led to ... pyridine do have an anchoring function in the phospholipid component of the cell membrane. In the development of MK-869, it was ... The discovery of neurokinin 1 (NK1) receptor antagonists was a turning point in the prevention of nausea and vomiting ... Neurokinin 1 (NK1) antagonists (-pitants) are a novel class of medications that possesses unique antidepressant, anxiolytic, ...
... such as neurokinin A and neurokinin B, specifically in the sympathetic portion of these fibres. General somatic afferent fibers ... where the cell body of the visceral afferent nerve is located. Finally, the signal continues along the dorsal root from the ...
Neurokinin-1 Receptor-Expressing Cells of the Ventral Respiratory Group Are Functionally Heterogeneous and Predominantly ... Neurokinin-1 Receptor-Expressing Cells of the Ventral Respiratory Group Are Functionally Heterogeneous and Predominantly ... Neurokinin-1 Receptor-Expressing Cells of the Ventral Respiratory Group Are Functionally Heterogeneous and Predominantly ... Neurokinin-1 Receptor-Expressing Cells of the Ventral Respiratory Group Are Functionally Heterogeneous and Predominantly ...
... the precursor of neurokinin B, constitute 5% of neurons in the dorsal striatum and project to the substantia innominata (SI) ... Neurokinin B-producing projection neurons in the lateral stripe of the striatum and cell clusters of the accumbens nucleus in ... In the ventral striatum, PPTB-producing neurons are collected mainly in the lateral stripe of the striatum (LSS) and cell ... Thus, we divided the PPTB-immunoreactive cell clusters into the LSS-associated and non-LSS-associated ones. We next ...
Neurokinin-1 cells in laminae III/IV project to regions of the brain which are involved in nociceptive processing and are ... of laminae III/IV neurons which possess the neurokinin-1 receptor. Statistical analysis confirms that cells belonging to this ... evidence for selective modulation by serotonin of a subpopulation of dorsal horn cells which possess the neurokinin-1 receptor ... In this study we report that serotonin-containing axons form basket-like clusters which are intimately woven around cell bodies ...
... simple luminescent calcium flux assays using an AequoScreen cell line stably-transfected with human neurokinin NK2 receptor. ... AequoScreen® Double Transfected Cell Lines: Neurokinin, NK2 subtype. Human Recombinant, in CHO-K1 host cell. Two vials of ... This product contains living cells. Some cells may be restricted for sale in specified countries. Please inquire at your local ... All cell lines are tested for the absence of mycoplasma. Terms and conditions apply. Some products are not available in some ...
Lack of neurokinin-1 receptor expression affects tissue mast cell numbers but not their spatial relationship with nerves. ... Fingerprint Dive into the research topics of Lack of neurokinin-1 receptor expression affects tissue mast cell numbers but not ...
Stable recombinant cell line expressing the Neurokinin, NK2 receptor. Human recombinant, in CHO-K1 host cell. We provide: Two ... Disclaimer: This product contains living cells. Some cells may be restricted for sale in specified countries. Please inquire at ... vials of the recombinant cell line as frozen cells; Detailed product information including sequence, cell line properties, ... In our ""standard"" cell lines where clonal selection is carried out with receptor binding: high and low expressors are then ...
Category Archives: Neurokinin Receptors MicroRNAs (miRNAs) are critical regulators of nervous program function, and in Leave a ... This entry was posted in Neurokinin Receptors and tagged ITF2357, Rabbit Polyclonal to EDG2. on May 16, 2017. by Gordon Gregory ... Supplementary MaterialsS1 Table: IC50 ideals of BT and paclitaxel in various ovarian malignancy cell lines, at 48 hours post- ... In this relative line, fluorescent tdTomato was portrayed in every cells having undergone Cre recombination; tdTomato could ...
Adoptive transfer; Dendritic cells; Neuropeptides; Type-1 T cell responses; Cellular immunity; Tachykinins; Cell survival. ... Role of Neurokinin 1 Receptor in Modulating the Immune-Stimulatory Function of Dendritic Cells ... Janelsins, Brian Mark (2010) Role of Neurokinin 1 Receptor in Modulating the Immune-Stimulatory Function of Dendritic Cells. ... favors cellular immunity by binding the neurokinin 1 receptor (NK1R) to promote immune cell survival and activation. Dendritic ...
Neurokinin receptors were present at the cell surface and in endosomes of neurons, interstitial cells, and myocytes. SP and NKA ... Cell lines. Sarcoma virus-transformed rat kidney epithelial cells (KNRK) and Chinese hamster ovary cells (CHO) were from ... Cells were screened for functional expression of neurokinin receptors by measurement of changes in [Ca2+]i in response to ... Neurokinin receptors have been localized in cells with high resolution using fluorescent ligands (Garland et al., 1994; Bunnett ...
... human IM9 cells, Ki = 0.42 μM; human cortex,Ki = 1.5 μM; guinea pig cortex,Ki = 7.6 μM; rat brain,Ki = 23.5 μM; mouse brain,Ki ... 1995) Antinociceptive profiles of non-peptidergic neurokinin 1 and neurokinin 2 receptor antagonists: A comparison to other ... LY303870, a Centrally Active Neurokinin-1 Antagonist with a Long Duration of Action. S. Iyengar, P. A. Hipskind, D. R. Gehlert ... LY303870, a Centrally Active Neurokinin-1 Antagonist with a Long Duration of Action. S. Iyengar, P. A. Hipskind, D. R. Gehlert ...
Data are presented as total mRNA (number of cells × grains/cell) assessed by in situ hybridization. * p , 0.05, by unpaired ... Human genetic studies have revealed that neurokinin B (NKB) and its receptor, neurokinin-3 receptor (NK3R), are essential ... Role of neurokinin B in the control of female puberty and its modulation by metabolic status.. Navarro VM1, Ruiz-Pino F, ... Role of Neurokinin B in the Control of Female Puberty and Its Modulation by Metabolic Status ...
Changes in bone tissue cells structure during brittle bones likely disrupt the mechanical environment of bone tissue cells and ... This lead in a total of 240 cells, with 160 and 80 of each cell type for both Scam and OVX pets, at 5 and. ... and evaluate these to cells within the bone tissue cells of sham-operated settings. Strategies and Components Custom-designed ... Changes in bone tissue cells structure during brittle bones likely disrupt On February 17, 2018 by Elmer Brooks With 0 Comments ...
bloodstream NK cells. We directed to measure the distinctions in percentage of uNK cells and their phenotypical ... an activating receptor of uNK cells, is normally portrayed in endometrial uNK cells in the nonpregnant endometrium of human ... bloodstream NK cells. We directed On May 28, 2019 by Elmer Brooks With 0 Comments - Main ... We suggest that the menstrual bloodstream NK cells researched by vehicle der Molen et al. will probably result from the. ...
A, CD34+ progenitor cells from human peripheral blood (hPB) express neuropeptide receptors. NK1 indicates neurokinin 1; CRLR, ... A, SP (SPmig cells) and CGRP (CGRPmig cells) induce migration and enrichment of progenitor cells that express the stem cell ... A substantial fraction of NK1+, RAMP-1+, and CRLR+ cells are Lin− and express the progenitor cell markers c-Kit (c-Kit+) and ... J, Levels of SP and abundance of NK1+CD34+CD45+ cells and NK1+CD34+CD45− cells in hearts of transplanted (n=6) and ...
Effects of bone marrow reconstitution with WT cells in WT and PPT-A gene-deleted (PPT-A-/-) mice and with PPT-A-/- cells in WT ... and possibly other cells such as mast cells into the inflammatory process, rather than the contrary. Inflammatory cells then ... These mice exhibit no evidence of neurokinin receptor downregulation in NK-1R-expressing cells (17) and, as noted above (see ... Cells were counted and diluted to administer a total dose of 2 × 106 nucleated cells. A wait period of at least 145 days was ...
Neurokinin A suppresses a voltage-gated K+ current in smooth muscle cells from rat vas deferens. In: European Journal of ... Neurokinin A suppresses a voltage-gated K+ current in smooth muscle cells from rat vas deferens. / Ken Nakazawa, Nakazawa; ... The effects of neurokinin A (NKA) on freshly isolated smooth muscle cells from the rat vas deferens were investigated ... Neurokinin A suppresses a voltage-gated K+ current in smooth muscle cells from rat vas deferens. ...
Bone marrow transplantation reveals an essential synergy between neuronal and hemopoietic cell neurokinin production in ... Bone marrow transplantation reveals an essential synergy between neuronal and hemopoietic cell neurokinin production in ... these findings demonstrate a critical synergy between capsaicin-sensitive sensory fibers and hemopoietic cells in neurokinin- ... revealing that PPT-A gene expression in hemopoietic cells has a previously unanticipated essential role in tissue injury. Taken ...
Cell Membrane / drug effects * Cell Membrane / metabolism * Guinea Pigs * Lung / drug effects ... Studies on Neurokinin Antagonists. 1. The Design of Novel Tripeptides Possessing the glutaminyl-D-tryptophylphenylalanine ...
... neurokinin-1 antagonist aprepitant in combination with a 5HT3 receptor antagonist and dexamethasone in patients with germ cell ... Neoplasms, Germ Cell and Embryonal. Neoplasms by Histologic Type. Neoplasms. Dexamethasone acetate. Dexamethasone. Aprepitant. ... Cisplatin-based regimen for germ cell tumors containing 20mg/m2/day IV days 1 through 5, first day of chemotherapy ... Histologic, serologic or clinical evidence of germ cell tumor.. *Patients scheduled to receive a 5 day fractionated cisplatin- ...
A direct neurokinin B projection from the arcuate nucleus regulates magnocellular vasopressin cells of the supraoptic nucleus. ... A direct neurokinin B projection from the arcuate nucleus regulates magnocellular vasopressin cells of the supraoptic nucleus. ... A direct neurokinin B projection from the arcuate nucleus regulates magnocellular vasopressin cells of the supraoptic nucleus. ... A direct neurokinin B projection from the arcuate nucleus regulates magnocellular vasopressin cells of the supraoptic nucleus. ...
Neurokinin A has an inhibitory effect on the formation of myeloid cells, and appear to be involved in one specific receptor ... Neurokinin A was shown to be a potent chemo attractor for T-cells increasing the migration into infected tissues. This ... 2008 Sep;295(3):C679-91 Like Substance P [SP], Neurokinin A is present in excitatory neurons and secretory cells of the ... Inflammation, tissue healing and cell proliferation have been linked to both SP and neurokinin A release into surrounding ...
Recent studies suggested that cell apoptosis and autophagy might play key roles in acupuncture therapy. Therefore, we searched ... These findings demonstrated that acupuncture has a potential role in modulating cell apoptosis and autophagy in animal models, ... aiming to find the potential relationship between acupuncture and cell apoptosis and autophagy. To provide readers with ... neurokinin 1 receptor; BrdU: 5-bromo-2′-deoxyuridine; ERK1/2: Ras-dependent extracellular signal-regulated kinase 1/2; CUS: ...
Buy Neurokinin A (CAS 86933-74-6), an endogenous tachykinin agonist with preference for the NK-2R, from Santa Cruz. MF: ... along with paralleled increase in intracellular free Ca2+ in BHK-21 cells with the NK-2R gene were stimulated with Neurokinin A ... Neurokinin 2 receptor: IC50 = 1 nM (human); Neurokinin 1 receptor: IC50 = 3.5 nM (human); Neurokinin 3 receptor: IC50 = 45 nM ( ... Neurokinin A (CAS 86933-74-6) Neurokinin A , CAS 86933-74-6 is rated 5.0 out of 5 by 1. ...
An antiangiogenic neurokinin-B/thromboxane A2 regulatory axis. J Cell Biol. 2006;174:1047-1058. doi: 10.1083/jcb.200603152. [ ... Liu Y, Chen X, Chen H. Placental and umbilical cord levels of neurokinin B and neurokinin B receptor in pre-eclampsia. Int J ... Vasoactive effects of neurokinin B on human blood vessels. Am J Obstet Gynecol. 2003;188:196-202. doi: 10.1067/mob.2003.114. [ ... Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia. Mol Hum Reprod. 2006;12:427-433. doi ...
Context: Kisspeptin and neurokinin B (NKB) are obligate for regular gonadotropin. Context: Kisspeptin and neurokinin B (NKB) ... Purpose Patients receiving intravenous cells plasminogen activator (tPA) for ischemic heart. May 21, 2016. FLT3 ... Purpose Patients receiving intravenous cells plasminogen activator (tPA) for ischemic heart stroke are monitored within an ...
... cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and ... Antitumoral action of the neurokinin-1 receptor antagonist L-733 060 on human melanoma cell lines. Muñoz, Miguel; Pérez, Ana; ...
Cells were cultured in 5% CO. 2 and 95% air at 37° C. Exponentially growing cells were harvested and washed twice in phosphate ... Neurokinin B. Asp. 1. -Met. 2. -His. 3. -. Asp. 4. -Phe. 5. -. Phe. 6. -Val. 7. -. Gly. 8. -. Leu. 9. -. Met. 10. -NH2. ... Stimulation of epithelial cell growth by the neuropeptide substance P," J. Cell. Biochem. 52:476-485. ... Unlike hormones that are produced by specialized cells or glands, cytokines are secreted proteins produced by a number of cell ...
ABBREVIATIONS: SP, substance P; NK-1R, neurokinin-1 receptor; NF, nuclear factor; IL-8, interleukin-8; TNFα, tumor necrosis ... Substance P-Stimulated Interleukin-8 Expression in Human Colonic Epithelial Cells Involves Protein Kinase Cδ Activation. Hon- ... Substance P-Stimulated Interleukin-8 Expression in Human Colonic Epithelial Cells Involves Protein Kinase Cδ Activation. Hon- ... Substance P-Stimulated Interleukin-8 Expression in Human Colonic Epithelial Cells Involves Protein Kinase Cδ Activation. Hon- ...
Pre-Bötzinger Complex Neurokinin-1 Receptor Expressing Neurons in Primary Cell Culture ... Stimulatory Actions of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Rat Carotid Glomus Cells ...
Natural killer cells misinterpret the fetal cells as cancer cells and attack them. An individual that presents with ... For this purpose, it uses several mechanisms: It secretes Neurokinin B containing phosphocholine molecules. This is the same ... These phospholipids are essential in the aiding the cells of the fetus to remain attached to the cells of the uterus with ... Also, there is presence of small lymphocytic suppressor cells in the fetus that inhibit maternal cytotoxic T cells by ...
  • We raised antisera by immunizing rabbits with peptides corresponding to portions of the intracellular tails of the rat neurokinin 1, 2, and 3 receptors (NK1-R, NK2-R, NK3-R). Receptors were localized by immunofluorescence and confocal microscopy. (jneurosci.org)
  • Each antiserum only stained cells transfected with the appropriate receptor and did not stain cells transfected with the other receptors. (jneurosci.org)
  • Therefore, the antisera are specific and do not cross-react with other neurokinin receptors. (jneurosci.org)
  • We examined the distribution of the neurokinin receptors in the gastrointestinal tract of the rat. (jneurosci.org)
  • Cells expressing the receptors were closely associated with tachykinin-containing nerve fibers. (jneurosci.org)
  • Far less is known about the distribution of the neurokinin receptors, because specific antisera have not been available. (jneurosci.org)
  • However, fluorescent and radiolabeled peptides interact with more than one neurokinin receptor or may detect binding sites that are not receptors. (jneurosci.org)
  • The selective neurokinin (NK)-1 antagonist LY303870 has high affinity and specificity for human and guinea pig brain NK-1 receptors labeled with 125 I-substance P. It has approximately 15- to 30-fold lower affinity for rat and mouse brain NK-1 receptors, consistent with previously reported species differences in the affinities of nonpeptide antagonists for NK-1 receptors. (aspetjournals.org)
  • This drug is highly selective for NK-1 receptors and binds with very high affinity to human NK-1 sites labeled by 125 I-SP, both in the periphery (IM9 cells, K i = 0.15 nM) and in brain (cortex, K i = 0.10 nM). (aspetjournals.org)
  • Curated secretory stage endometrial microarray datasets had been interrogated for NK cell receptors and their ligands. (neurokinin-receptor.info)
  • Bioinformatics analysis The part of important receptors on human being NK cells was examined by collating a list of inhibitory and activating receptors, adhesion molecules or co-stimulatory molecules [33]. (neurokinin-receptor.info)
  • Bone marrow progenitor cells express substance P and calcitonin gene-related peptide receptors. (nih.gov)
  • Central administration of neurokinin B (NKB) agonists stimulates immediate early gene expression in the hypothalamus and increases secretion of vasopressin from the posterior pituitary through a mechanism that depends on the activation of neurokinin receptor 3 receptors (NK3R). (ed.ac.uk)
  • Since lymphocytes must be positioned correctly to interact with other cells, the pattern of chemokine receptors and the type and distribution of chemokines in tissues critically influence immune responses. (wikipedia.org)
  • Neurokinin A has also been used to discover the location of tachykinin receptors. (scbt.com)
  • PubMed ID 10889154) found that neurokinin A activated Gq-linked NK(2) receptors, inducing contraction and increase in cytosolic Ca(2+) in human sigmoid circular smooth muscle. (scbt.com)
  • Over several days in vivo, saporin-mediated destruction of preBötC neurons that express neurokinin-1 receptors (NK1Rs) causes sleep-disordered breathing and fatal respiratory pathology ( 5 , 6 ). (pnas.org)
  • Inositol phosphate accumulation by Gq-coupled M3-muscarinic, thromboxane-A2, and 5-HT2 receptors was desensitized in airway smooth muscle cells from βAR-/- mice and sensitized in cells from β2AR-OE mice. (jci.org)
  • The Neurokinin 3 receptor is a part of a larger family of G-protein coupled receptors that binds all tachykinin proteins. (wikipedia.org)
  • While neurokinin B has the ability to bind to other Neurokinin receptors, the highest affinity lies in that of the NK3R receptor group. (wikipedia.org)
  • Neurokinin B has also been found to co-localize certain gonadal steroid hormone receptors. (wikipedia.org)
  • The kisspeptin, neurokinin B, and dynorphin cell groups are found to be co-localized to more than 95% of all of the aforementioned receptors in the arcuate nucleus. (wikipedia.org)
  • G protein-coupled receptors (GPCR) constitute by far the largest family of transmembrane cell-surface proteins involved in signal transduction and are the most important targets for the development of novel therapeutic compounds. (epfl.ch)
  • T-cell activation results from signals delivered by antigen presenting cells (APC) to the antigen-specific T-cell receptor (TCR) and to costimulatory or coinhibitory receptors on T cells. (aacrjournals.org)
  • Role of protein kinase C in caerulein induced expression of substance P and neurokinin-1-receptors in murine pancreatic acinar cells. (otago.ac.nz)
  • [9] Other neurokinin subtypes and neurokinin receptors that interact with SP have been reported as well. (wikipedia.org)
  • Mast cells are found in areas exposed to the external environment and are activated by diverse stimuli, including IgE receptor (FcεRI) cross-linking and neuropeptides such as substance P (SP) 4 that act on G protein-coupled receptors. (jimmunol.org)
  • While it was thought that receptors function at the surface of nerve cells, they discovered that activated receptors move within the cell to a compartment called the endosome. (brightsurf.com)
  • The researchers suspected that these drugs failed to work because they were designed to block receptors at the surface of cells rather than in endosomes. (brightsurf.com)
  • We recently reported that both neurokinin 1 receptors and bradykinin 2 receptors are upregulated in dorsal root ganglion (DRG) neurones (the cell bodies of sensory fibres) in the course of acute and chronic antigen-induced arthritis in the rat. (biomedcentral.com)
  • The proportion of DRG neurones expressing bradykinin 2 receptors was slightly upregulated in the presence of FLS cells from normal joints but upregulation was more pronounced in DRG neurones co-cultured with FLS cells from acutely inflamed joints. (biomedcentral.com)
  • Upregulation of neurokinin 1 receptors but not of bradykinin 2 and TRPV1 receptors was also observed when only the supernatant of FLS cells from acutely inflamed joint was added to DRG neurones. (biomedcentral.com)
  • Collectively, these data show that FLS cells are able to induce an upregulation of pain-related receptors in sensory neurones and, thus, they could contribute to the generation of joint pain. (biomedcentral.com)
  • Netupitant is a selective antagonist of human substance P/neurokinin 1 (NK 1 ) receptors. (mims.com)
  • Delayed emesis has been associated with the activation of tachykinin family neurokinin 1 (NK 1 ) receptors (broadly distributed in the central and peripheral nervous systems) by substance P. As shown in in vitro and in vivo studies, netupitant inhibits substance P mediated responses. (mims.com)
  • Rat gastrointestinal motor responses mediated via activation of neurokinin receptors. (wikigenes.org)
  • Netupitant is a selective antagonist of substance P/neurokinin 1 receptors. (ascopost.com)
  • Delayed emesis is largely associated with substance P activation of tachykinin family neurokinin 1 receptors, distributed in the central and peripheral nervous systems. (ascopost.com)
  • the neurokinin-1 receptor (NK1R)-immunoreactive (ir) neurons of the ventral respiratory group (VRG) are confined to the pre-Bötzinger complex (pre-BötC) and might be glutamatergic interneurons that drive respiratory rhythmogenesis. (jneurosci.org)
  • We also examined whether different groups of NK1R-ir neurons coexist in the VRG on the basis of whether these cells contain preproenkephalin (PPE) mRNA or project to the spinal cord. (jneurosci.org)
  • In summary, NK1R-expressing cells of the VRG are a heterogeneous group of predominantly glutamatergic neurons that include subpopulations of respiratory premotor neurons. (jneurosci.org)
  • However, this theory is based on three basically undemonstrated assumptions: namely, the NK1R-immunoreactive (ir) cells of the adult VRG are glutamatergic neurons and confined to the pre-BötC, they are propriomedullary, and they are functionally homogeneous. (jneurosci.org)
  • To determine whether VRG NK1R-ir cells are a functionally homogeneous population, we analyzed the pattern of expression of another marker, preproenkephalin (PPE) mRNA and found that this marker is associated with two morphologically different types of VRG NK1R-ir neurons. (jneurosci.org)
  • Neurons producing preprotachykinin B (PPTB), the precursor of neurokinin B, constitute 5% of neurons in the dorsal striatum and project to the substantia innominata (SI) selectively. (nih.gov)
  • In the ventral striatum, PPTB-producing neurons are collected mainly in the lateral stripe of the striatum (LSS) and cell clusters of the accumbens nucleus (Acb). (nih.gov)
  • In the present study, we first examined the distribution of PPTB-immunoreactive neurons in rat ventral striatum and found that a large part of the PPTB-immunoreactive cell clusters was continuous to the LSS, but a smaller part was not. (nih.gov)
  • After injection of Fluoro-Gold into the basal component of the SI (SIb) and medial part of the interstitial nucleus of posterior limb of the anterior commissure, many PPTB-immunoreactive neurons were retrogradely labeled in the LSS-associated cell clusters and LSS, respectively. (nih.gov)
  • When the injection site included the ventral part of the sublenticular component of the SI(SIsl), retrogradely labeled neurons showed PPTB-immunoreactivity frequently in non-LSS-associated cell clusters. (nih.gov)
  • In this study we report that serotonin-containing axons form basket-like clusters which are intimately woven around cell bodies and proximal dendrites of a subpopulation (≈ 50%) of laminae III/IV neurons which possess the neurokinin-1 receptor. (gla.ac.uk)
  • NK1-R was detected in myenteric and submucosal neurons and in interstitial cells of Cajal. (jneurosci.org)
  • SP-containing terminals appose nociception-specific dorsal horn neurons, and SP selectively activates dorsal horn cells that normally receive nociceptive inputs ( Henry, 1976 ), causing a powerful sustained excitation of second-order sensory neurons in the spinal cord. (aspetjournals.org)
  • In addition, the detection of PPT-A mRNAs and substance P-like immunoreactivity in intrinsic airway neurons ( 8 , 9 ) and, more recently, in inflammatory cells ( 10 - 15 ) has uncovered the existence of two cellular reservoirs of neurokinins in the lungs, one constitutive and the other migrant. (jci.org)
  • 2008 Sep;295(3):C679-91 Like Substance P [SP], Neurokinin A is present in excitatory neurons and secretory cells of the hypothalamic-pituitary-adrenal axis. (wikipedia.org)
  • Similarly, acute cell-silencing of a subset of the same NK1R-expressing population of preBötC neurons stops spontaneous breathing in awake adult rats ( 7 ). (pnas.org)
  • Its receptor - the neurokinin type 1 - is distributed over cytoplasmic and nuclear membranes of many cell types (neurons, glia, endothelia of capillaries and lymphatics, fibroblasts, stem cells, white blood cells) in many tissues and organs. (wikipedia.org)
  • This conjugate should be taken up selectively by neurokinin receptor expressing neurons resulting in enhanced adenylate cyclase activity and neuronal firing. (sigmaaldrich.com)
  • The finding that stimulation of adenylate cyclase in neurokinin receptor expressing neurons in the spinal cord produces thermal hyperalgesia is consistent with the known actions of these neurons. (sigmaaldrich.com)
  • Gastrointestinal (GI) motility function and its regulation is a complex process involving collaboration and communication of multiple cell types such as enteric neurons, interstitial cells of Cajal (ICC), and smooth muscle cells. (biomedsearch.com)
  • Interstitial cells of Cajal (ICC) were initially identified by Cajal[ 1 ] who first described nerve-like cells at the ends of motor neurons in organs innervated by peripheral nerves, and on the basis of staining characteristics with methylene blue and silver chromate, he classified them as primitive neurons. (biomedsearch.com)
  • Taxi,[ 2 , 3 ] on the other hand, using light and electron microscopy, referred these cells as neuronoids in an attempt to distinguish them from neurons, Schwann cells, smooth muscle cells, fibroblasts, and macrophages, although these cells co-stained with nerves. (biomedsearch.com)
  • Significantly not all ICC do express c-Kit, such as those in the deep muscular plexus in the human small intestine[ 10 ] and still other different cell types besides ICC do also express c-Kit, such as mast cells, melanocytes, neurons, and glia. (biomedsearch.com)
  • Secretion of pro-inflammatory neuropeptides from the tachykinin family, including substance P (SP) and hemokinin-1 (HK-1), favors cellular immunity by binding the neurokinin 1 receptor (NK1R) to promote immune cell survival and activation. (pitt.edu)
  • The tachykinin family of neuropeptides includes substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). (jneurosci.org)
  • Neurokinin A (formally known as substance K) is a member of the tachykinin family of neuropeptide neurotransmitters. (wikipedia.org)
  • The neurokinin 1 receptor (NK-1R) is the main receptor for the tachykinin family of peptides. (hindawi.com)
  • The three classical members of the mammalian tachykinin family are SP and neurokinin A (NKA), both encoded by the TAC1 gene, and neurokinin B (NKB), encoded by the TAC3 gene. (hindawi.com)
  • Jointly, these results demonstrate for the very first time the results of conditional, particular miRNA reduction in the mammalian cortex aswell as reveal a significant non-cell-autonomous function for miRNAs on inhibitory synaptic transmitting and interneuron advancement. (cp-724714.com)
  • Neurokinin A has many excitatory effects on mammalian nervous systems and is also influential on the mammalian inflammatory and pain responses. (wikipedia.org)
  • Neurokinin A is ubiquitous in both the central and peripheral mammalian nervous systems, and seems to be involved in reactions to pain and the inflammatory responses. (wikipedia.org)
  • This neuropeptide family is composed of substance P, neurokinin A, and neurokinin B, which are widely distributed in mammalian central and peripheral nervous systems. (genscript.com)
  • Our measurements provide an upper limit for tolerance to cell destruction in a mammalian CPG. (pnas.org)
  • If you generate more plasmid DNA by bacterial transformation, we recommend isolating the plasmid DNA using an endotoxin-free plasmid prep kit prior to transfection into mammalian cells. (neb.com)
  • A major alternative left by elimination is that the NK1R-ir cells of the VRG are glutamatergic (H. (jneurosci.org)
  • To test whether the NK1R-expressing cells are confined to the Pre-BötC and exclusively propriomedullary, we examined whether any of them project to the cervical and thoracic cord. (jneurosci.org)
  • Since DCs home strategically to peripheral and lymphoid tissues where tachykinins are secreted, we hypothesized that signaling via the NK1R enhances DC longevity and their T cell-stimulatory function, including the induction of type-1 CD4+ T cell helper (Th1) and CD8+ cytotoxic T cell (CTL/Tc1) responses. (pitt.edu)
  • However, both the CD14 + NK1R + population and MFI of NK1R expression on CD14 + cells were enhanced in the blood of AD patients. (biomedcentral.com)
  • Since peripheral blood mononuclear cells (PBMCs) from AD patients proliferate at a high rate [ 10 ] and human monocyte/macrophage cell line THP-1 expresses functional SP receptor NK1R [ 11 ], it is likely that SP and NK1R expressing monocytes are enhanced in patients with AD. (biomedcentral.com)
  • The thesis presented here describes investigations on the neurokinin-1 receptor (NK1R), a member of the GPCR family, using fluorescence techniques. (epfl.ch)
  • Here, the NK1R was immobilized directly on a surface using a cell membrane preparation. (epfl.ch)
  • The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). (wikipedia.org)
  • The aim of the present study was to investigate the inhibitory effect of BTX-A on rat pyloric muscle contractile response to SP in vitro and the distributions of SP and neurokinin 1 receptor (NK1R) immunoreactive (IR) cells and fibers within pylorus. (mdpi.com)
  • SP-IR fibers and NK1R-IR cells both located within pylorus including mucosa and circular muscle layer. (mdpi.com)
  • Synthesis and Evaluation of a Novel 64Cu- and 67Ga-Labeled Neurokinin 1 Receptor Antagonist for in Vivo Targeting of NK1R-Positive Tumor Xenografts. (purdue.edu)
  • This control plasmid contains the gene encoding the seven-pass transmembrane protein Neurokinin-1 receptor (NK1R), a member of the G-protein coupled receptor family. (neb.com)
  • The CLIP f -NK1R fusion protein gives plasma membrane labeling when labeled with cell permeable CLIP-Cell™ substrates and non-cell permeable CLIP-Surface substrates. (neb.com)
  • Live CHO-K1 cells transiently transfected with pCLIP f -NK1R. (neb.com)
  • Surprisingly, reconstitution of WT mice with PPT-A gene-deficient bone marrow also confers protection against pulmonary injury, revealing that PPT-A gene expression in hemopoietic cells has a previously unanticipated essential role in tissue injury. (jci.org)
  • Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene. (wikipedia.org)
  • It is produced from the same preprotachykinin A gene as the neuropeptide substance P. Both substance P and neurokinin A are encoded by the same mRNA, which when alternatively spliced can be translated into either compound. (wikipedia.org)
  • Modified from: Sun J, Ramnath RD, Tamizhselvi R, Bhatia M."Neurokinin A engages neurokinin-1 receptor to induce NF-kappaB-dependent gene expression in murine macrophages: implications of ERK1/2 and PI 3-kinase/Akt pathways. (wikipedia.org)
  • An increase in inositol 1,4,5-trisphosphate (IP3) levels along with paralleled increase in intracellular free Ca 2+ in BHK-21 cells with the NK-2R gene were stimulated with Neurokinin A. The compound has also been observed to induce contraction in muscle strips and single cells of the human sigmoid colon circular muscle. (scbt.com)
  • 2 The genetic and molecular bases are fully characterized: SCD originates from a single nucleotide mutation of the β-globin gene, leading to polymerization of the abnormal deoxygenated hemoglobin S (HbS), which results in obstruction of small vessels by sickle-shaped red blood cells (RBC). (haematologica.org)
  • Among the alpha, beta, and gamma transcripts of the substance P gene, only the beta and gamma transcripts are detectable in these cells. (jimmunol.org)
  • In the present study, the Stat-3 gene was selectively deleted in respiratory epithelial cells by conditional expression of Cre-recombinase under control of the surfactant protein C gene promoter. (jci.org)
  • Neurokinin b (NKB), is encoded by the TAC3 gene in humans and Tac2 in rodent species. (wikipedia.org)
  • Five exon segments in the TAC3 gene encode for the NKB precursor known as preprotachykinin B. Preprotachykinin B is then proteolytically cleaved into the pro-peptide proneurokinin B. A second proteolytic cleavage of proneurokinin B produces the final product neurokinin B. During the ovarian cycle, GnRH secretion along with that of luteinizing hormone (LH) is highly regulated. (wikipedia.org)
  • Much like the neurokinin B peptide, the NK3R receptor that it binds to is encoded within five exons of the TACR3 gene in humans and the Tacr3 gene in mice and other rodents. (wikipedia.org)
  • The extracellular domain of DC-HIL contains a cell-adhesion (RGD) motif, a proline-rich region, and an immunoglobulin-like polycystic kidney disease domain shared by polycystic kidney disease-susceptible gene products ( 18 ). (aacrjournals.org)
  • Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity of LPS-activated RAW264.7 cells. (otago.ac.nz)
  • [1] [2] Substance P and its closely related neurokinin A (NKA) are produced from a polyprotein precursor after differential splicing of the preprotachykinin A gene . (wikipedia.org)
  • IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. (peprotech.com)
  • It is known that SP, neurokinin A (NKA), neuropeptide K and neuropeptide Gamma (the two latter elongated forms of NKA) are derived from the preprotachykinin A gene, whereas neurokinin B (NKB) is derived from the preprotachykinin B gene. (mdpi.com)
  • Studies have shown that stress-induced activation of the noradrenergic prefrontal lobe system may be under the control of both endogenously released corticotrophin-releasing hormone and SP and neurokinin A. This study directly links the secretion of neurokinin A and SP to certain forms of depression characterized by the corticoid receptor hypothesis of depression. (wikipedia.org)
  • Neurokinin A has been reported to effect reproduction by controlling at the hypothalamus level gonadotropin and prolactin secretion along with steroid secretion at the ovarian and gonadal level. (scbt.com)
  • Particularly, NK-1R is found in the nervous system and in peripheral tissues and are involved in cellular responses such as pain transmission, endocrine and paracrine secretion, vasodilation, and modulation of cell proliferation. (hindawi.com)
  • Neurokinin B is implicated in a variety of human functions and pathways such as the secretion of gonadotropin-releasing hormone. (wikipedia.org)
  • On the other hand, tumors can use a variety of mechanisms that allow their escape from immunologic surveillance and destruction, including poorly expressed tumor-associated antigens (TAA), self-tolerance to TAA, downregulated MHC molecules, secretion of immunosuppressive cytokines [transforming growth factor, interleukin (IL)-10, and vascular endothelial growth factor], and deficient T-cell costimulation ( 2 , 3 ). (aacrjournals.org)
  • Sex steroids and odorants modulate gonadotropin-releasing hormone secretion in primary cultures of human olfactory cells. (springer.com)
  • Uncoupling protein 2 (UCP2) is a mitochondrial protein that inhibits insulin secretion from β cells, possibly through down-regulation of reactive oxygen species production. (jimmunol.org)
  • Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. (peprotech.com)
  • Cortisol secretion induced by substance P from bovine adrenocortical cells and its inhibition by calmodulin inhibitors. (wikigenes.org)
  • The effects of neurokinin A (NKA) on freshly isolated smooth muscle cells from the rat vas deferens were investigated electrophysiologically. (elsevier.com)
  • The ability of a tachykinin to interact with a receptor depends on the proximity of sites of peptide release to receptor-bearing cells, so that the required peptide concentration for receptor activation is achieved, and on whether a receptor is available and appropriately coupled. (jneurosci.org)
  • At the start of the last decade, we provided evidence that levels of the peptide neurokinin B were highly elevated in pre-eclampsia. (pubmedcentralcanada.ca)
  • Neurokinin B is found in humans as a ten-peptide chain (decapeptide) attached to a terminal amide group. (wikipedia.org)
  • The tachykinin peptide family in mammals comprises three peptides, substance P, neurokinin A and neurokinin B, which bind to the tachykinin receptor family of GPCRs, NK1, NK2 and NK3. (creative-biogene.com)
  • These data demonstrate that cholera toxin can be targeted to specific cell types by coupling the catalytic subunit to a peptide agonist for a g-protein coupled receptor. (sigmaaldrich.com)
  • In a 2014 Cell paper (10.1016/j.cell.2013.11.045), they found that the peptide controls the effects of social isolation to increase aggression in Drosophila. (eurekalert.org)
  • Inflammation, tissue healing and cell proliferation have been linked to both SP and neurokinin A release into surrounding tissues. (wikipedia.org)
  • A sufficient supply of progenitor stem cells to facilitate epithelial cell proliferation is important for the cornea. (medscape.com)
  • The Met-Janus kinase 1-STAT3 signaling pathway may be a major signaling pathway for DCP-induced cell proliferation. (labome.org)
  • The ED 50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10 6 units/mg. (peprotech.com)
  • Melatonin, as a new member of an expanding group of regulatory factors that control cell proliferation and loss, is the only known chronobiotic, hormonal regulator of neoplastic cell growth. (eurekaselect.com)
  • At physiological circulating concentrations, this indoleamine is cytostatic and inhibits cancer cell proliferation in vitro via specific cell cycle effects. (eurekaselect.com)
  • It has been recently demonstrated that substance P (SP) and neurokinin-1 (NK-1) receptor antagonists induce cell proliferation and cell inhibition in human melanoma cells, respectively. (mdpi.com)
  • Whereas wild-type PAR2 activates ERK1/2 by a PKC-dependent and probably a ras-independent pathway, PAR2(δST363/6A) appears to activate ERK1/2 by a ras-dependent pathway, resulting in increased cell proliferation. (rupress.org)
  • If a given agonist is intended to induce ERK-dependent phosphorylation of cytosolic substrates, but not induce proliferation, how does the cell ensure that ERK activation results in the correct response? (rupress.org)
  • RATIONALE: Antiemetic drugs, such as aprepitant, ondansetron, and dexamethasone, may help lessen or prevent nausea and vomiting in patients undergoing a stem cell transplant. (clinicaltrials.gov)
  • PURPOSE: This randomized clinical trial is studying aprepitant, ondansetron, and dexamethasone to see how well they work compared to placebo, ondansetron, and dexamethasone in preventing nausea and vomiting in patients who are undergoing a stem cell transplant. (clinicaltrials.gov)
  • Bunnett and his colleagues encapsulated into nanoparticles a neurokinin receptor blocker called aprepitant, an FDA-approved drug used to prevent nausea and vomiting that failed clinical trials as a pain medication. (brightsurf.com)
  • The nanoparticles were designed to enter nerves that transmit pain signals and release their aprepitant cargo in endosomes containing the neurokinin receptor. (brightsurf.com)
  • Hargreaves R, Ferreira JC, Hughes D, Brands J, Hale J, Mattson B, Mill S. Development of aprepitant, the first neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting. (vandapharma.com)
  • The main receptor neurokinin B interacts with is the neurokinin 3 receptor (NK3R). (wikipedia.org)
  • Taken together, these findings demonstrate a critical synergy between capsaicin-sensitive sensory fibers and hemopoietic cells in neurokinin-mediated inflammation and suggest that such synergy may be the basis for a stereotypical mechanism of response to injury in the respiratory tract. (jci.org)
  • Activation of NK-1R in smooth muscle cells, endothelial cells, and leukocytes decreases vascular tone, increases endothelial permeability, and promotes local inflow of inflammatory cells ( 4 ), thereby enhancing the inflammation induced by the original stimulus. (jci.org)
  • Substance P (SP) participates in acute intestinal inflammation via binding to the G-protein-coupled neurokinin-1 receptor (NK-1R) and release of nuclear factor κ B (NF-κB)-driven proinflammatory cytokines from colonic epithelial cells. (aspetjournals.org)
  • It has been increasingly suggested that innate immune cells, including monocytes, neutrophils, invariant natural killer T cells, platelets and mast cells, have a role in promoting inflammation, adhesion and pain in SCD. (haematologica.org)
  • To test safety and efficacy of topical application of the Neurokinin 1 receptor antagonist Fosaprepitant for the treatment of corneal inflammation in an alkali burn model. (arvojournals.org)
  • We conclude that topical application of Fosaprepitant can significantly inhibit inflammatory cell infiltration in the cornea after inflammation has occurred. (arvojournals.org)
  • Numerous cytokines and growth factors that are up-regulated in corneal cells further contribute to tissue inflammation. (medscape.com)
  • Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. (rndsystems.com)
  • Mast cells are immune effector cells that are involved in allergies and inflammation through the release of mediators such as histamine, PGs, and cytokines. (jimmunol.org)
  • In addition, the expression of the transient receptor potential V1 (TRPV1) receptor, which is involved in inflammation-evoked thermal hyperalgesia, was mainly upregulated by co-culturing DRG neurones with FLS cells from chronically inflamed joints. (biomedcentral.com)
  • Additionally both SP neurokinin A is found in the neurosensory system and modulates a wide range of inflammatory and tissue repairing processes [1]. (wikipedia.org)
  • Neurokinin A has been associated with the chemokines interleukin-1 and interleukin-6, both of which are heavily involved in the inflammatory process during infections. (wikipedia.org)
  • Inflammatory cell infiltration was quantified by means of: (a) immunofluorescence microscopy of CD45+ cells in the stroma of corneal whole mounts, and (b) flow cytometry of dissociated corneal stromal cells, stained with: CD45, CD11b, F4/80, Ly6G/Ly6C(GR1). (arvojournals.org)
  • Treatment with topical Fosaprepitant was effective in reducing inflammatory cell infiltration. (arvojournals.org)
  • Epithelial cell injury and inflammatory responses were increased in the Stat-3-deleted mice. (jci.org)
  • We, therefore, hypothesized that UCP2 could inhibit mast cell activation and decrease mast cell-mediated inflammatory responses. (jimmunol.org)
  • Our results indicate that UCP2 is a novel regulator of mast cell function with implications for treatment of mast cell-mediated allergic and inflammatory diseases. (jimmunol.org)
  • The inflammatory response in organs is produced by numerous inflammatory cell types. (biomedcentral.com)
  • These cell types communicate with each other in order to develop an appropriate inflammatory reaction. (biomedcentral.com)
  • These data have established the importance of both cell-cell contacts and mediators for the production of the inflammatory activity. (biomedcentral.com)
  • Despite the functional cross-talk between the inflammatory process and neurones, the mechanistic analysis of interactions between non-neuronal inflammatory cells and neurones has not been carried out in great detail. (biomedcentral.com)
  • Selective liposome targeting of folate receptor positive immune cells in inflammatory diseases. (purdue.edu)
  • What is the physiological significance of neurokinin B in the placenta? (pubmedcentralcanada.ca)
  • However, these antibodies do not target fetal cells, unless any fetal material has escaped across the placenta where it can come in contact with maternal B cells and make those B cells start to produce antibodies against fetal targets. (wikipedia.org)
  • The mother does produce antibodies against foreign ABO blood types, where the fetal blood cells are possible targets, but these preformed antibodies are usually of the IgM type, and therefore usually do not cross the placenta. (wikipedia.org)
  • Cell-selective deletion of Stat-3 in respiratory epithelial cells did not alter prenatal lung morphogenesis or postnatal lung function. (jci.org)
  • Expression of Stat-3 in respiratory epithelial cells is not required for lung formation, but plays a critical role in maintenance of surfactant homeostasis and lung function during oxygen injury. (jci.org)
  • Within minutes after a small corneal epithelial injury, cells at the edge of the abrasion begin to migrate centripetally to cover the defect rapidly at a rate of 60-80 µm/h. (medscape.com)
  • Epithelial cells adjacent to the area of the defect flatten, lose their hemidesmosome attachments, and migrate on transient focal contact zones that are formed between cytoplasmic actin filaments and extracellular matrix proteins. (medscape.com)
  • After 24-30 hours, mitosis begins to restore epithelial cell population. (medscape.com)
  • A deficiency of limbal stem cells, from either disease (eg, aniridia) or trauma (eg, chemical burn), can preclude adequate epithelial wound healing. (medscape.com)
  • Metalloproteinases are secreted as proenzymes by neutrophils infiltrating the wound, injured epithelial cells, and keratocytes. (medscape.com)
  • Germ cell tumors are relatively rare and represent a highly curable epithelial cancer. (renalandurologynews.com)
  • The concentration of serotoninergic axons around proximal regions of some of these cells indicates that serotonin may have a powerful influence on transmission through this pathway. (gla.ac.uk)
  • the serotonin, neurokinin and glucocorticoid systems. (www.nhs.uk)
  • Chemotherapeutic substances produce nausea and vomiting by stimulating the release of serotonin from the enterochromaffin cells of the small intestine. (mims.com)
  • Thus, NK1-R and NK3-R mediate neurotransmission by tachykinins within enteric nerve plexuses, and NK1-R and NK2-R mediate the effects of tachykinins on interstitial and smooth muscle cells, respectively. (jneurosci.org)
  • Tachykinins thus have a number of neuroprotective physiological roles in medical conditions The immune system is a highly integrated system which receives input from many sources, such as sites of injury, nociceptors and white blood cells. (wikipedia.org)
  • Substance P (SP), neurokinin A (NKA), neurokinin B (NKB), hemokinin-1, endokinin A and endokinin B are the major tachykinins found in mammals. (sigmaaldrich.com)
  • In addition to the primary (mechanical) injury caused at the time of the traumatic event, secondary injury factors play a major role in resultant neuronal cell death that results in lifelong disability experienced by many survivors. (frontiersin.org)
  • Sequence analysis of the RT-PCR products from both monocytes and macrophages also confirmed the structure of these transcripts, which are identical to those found in human neuronal cells. (jimmunol.org)
  • Neurokinin b is expressed along with the peptides kisspeptin and dynorphin A in the neuronal cells of the arcuate nucleus. (wikipedia.org)
  • A review of neurokinin B and its sister peptides, kisspeptin and dynorphin, in sheep found that these KNDy cell groups (kisspeptin, neurokinin B, dynorphin), are in direct contact with the GnRH neuronal bodies in both the preoptic area and the mediobasal hypothalamus. (wikipedia.org)
  • The basic premise of the eu-FEDS hypothesis is that both soluble and cell surface associated glycoproteins, present in the reproductive system and expressed on gametes, suppress any potential immune responses, and inhibit rejection of the fetus. (wikipedia.org)
  • The uncomplexed Bcl-xL is then capable of suppressing cell death responses by blocking the release of mitochondrial cytochrome c ( 24 ). (asm.org)
  • UCP2 activity inhibits exocytosis of insulin granules from pancreatic β cells ( 9 ) and dopamine-containing vesicles from rat PC12 cells ( 10 ). (jimmunol.org)
  • Pancreatic trypsin and mast cell tryptase cleave PAR2 within its extracellular NH 2 terminus (SKGR ↓ SLIGRL/KV, ↓ cleavage site for rat/human PAR2), exposing a tethered ligand domain (SLIGRL/KV) that binds to and activates the cleaved receptor. (rupress.org)
  • Experiments with selective antagonists of NK2, SR 48,968 and MEN 10,376 indicate that NK2 mediates neurokinin-induced constriction of pulmonary artery and bronchus. (creative-biogene.com)
  • An open label trial of folate receptor-targeted intraoperative molecular imaging to localize pulmonary squamous cell carcinomas. (purdue.edu)
  • 4 In vitro , the interaction of RBC from SCD patients with cultured human umbilical vein endothelial cells was responsible for enhanced cellular oxidant stress, resulting in a two-fold increase in transendothelial migration of human peripheral blood monocytes. (haematologica.org)
  • Other tissues, including endothelial cells and immune cells, also express NK-1R and could be considered to be targets for NK-1R antagonists2. (vandapharma.com)
  • In addition, using nested RT-PCR analysis, we identified the presence of mRNA for neurokinin-1 receptor (the receptor for substance P) in human peripheral blood-isolated monocytes and macrophages, which was confirmed by DNA sequencing analysis. (jimmunol.org)
  • Human Recombinant, in CHO-K1 host cell. (perkinelmer.com.cn)
  • We have demonstrated also, that NKp30, an activating receptor of uNK cells, is normally portrayed in endometrial uNK cells in the nonpregnant endometrium of human beings and in baboons which the NKp30 appearance boosts in the past due secretory stage in human beings. (neurokinin-receptor.info)
  • Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects. (nih.gov)
  • Here, we examined participation of protein kinase C (PKC) in SP-induced IL-8 production in human nontransformed NCM460 colonocytes stably transfected with the human NK-1R (NCM460-NK-1R cells). (aspetjournals.org)
  • The human neurokinin A (substance K) receptor. (wikipedia.org)
  • Human monocytes and macrophages express substance P and neurokinin-1 receptor. (jimmunol.org)
  • The demonstration that human monocytes and macrophages express substance P and its receptor support the notion that substance P is biologically involved in regulating the functions of these cells in an autocrine fashion. (jimmunol.org)
  • OVA-sensitized AD mice showed an elevated proportion and MFI of SP-expressing CD8 + T cells in the blood, which agrees with the SP expression situation in human AD blood. (biomedcentral.com)
  • Mineshiba J, Myokai F, Mineshiba F, Matsuura K, Nishimura F, Takashiba S. Transcriptional regulation of beta-defensin-2 by lipopolysaccharide in cultured human cervical carcinoma (HeLa) cells. (labome.org)
  • In this study, we show that mouse bone marrow mast cells (BMMCs) and human leukemic LAD2 mast cells express UCP2. (jimmunol.org)
  • Intradermal administration of substance P, an activator of skin mast cells, and challenge with DNP-human serum albumin after passive sensitization induced significantly greater vascular permeability in the skin of Ucp2 − / − mice in vivo. (jimmunol.org)
  • In this article, we show that UCP2 is expressed in both murine and human mast cells. (jimmunol.org)
  • Selective labeling and isolation of functional classes of interstitial cells of Cajal of human and murine small intestine. (semanticscholar.org)
  • Paracrine inhibition of GM-CSF signaling by human cytomegalovirus in monocytes differentiating to dendritic cells. (peprotech.com)
  • Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells. (peprotech.com)
  • Expression profiles of human interferon-alpha and interferon-lambda subtypes are ligand- and cell-dependent. (peprotech.com)
  • Human UC11 astrocytoma cells were used to investigate the role of protein kinase C (PKC) and other kinases in neurokinin (NK)1 receptor desensitization. (wmin.ac.uk)
  • The aim of this study was to demonstrate an antitumor action of L-732,138 against three human melanoma cell lines (COLO 858, MEL HO, COLO 679). (mdpi.com)
  • Bone edges are indicated by dashed lines, and hematopoietic cells are decorated by anti-CD45 antibody (red fluorescence). (nih.gov)
  • A , Immunostaining of lineage-negative (Lin − ) cells (selected with the use of magnetic beads and a cocktail of antibodies against committed hematopoietic cells) expressing neurokinin 1 (NK1) ( a ), receptor activity-modifying protein 1 (RAMP-1) ( b ), and calcitonin receptor-like receptor (CRLR) ( c ) (green). (nih.gov)
  • It has also been reported that SP interacts with fibronectin (FN) and hematopoietic growth factor inducible neurokinin-1 type (HGFIN) [ 13 , 14 ]. (hindawi.com)
  • ref. 15 ), osteoactivin ( 16 ), and hematopoietic growth factor-inducible neurokinin-1 type ( 17 ). (aacrjournals.org)
  • BCDA-01, our CardiAMP autologous cell therapy under Phase III clinical development for the treatment of ischemic heart failure remains the Company's top priority. (yahoo.com)
  • BCDA-02, our CardiAMP autologous cell therapy is under Phase III development for the treatment of chronic myocardial ischemia. (yahoo.com)
  • This is a big year ahead for BioCardia as we advance our two pivotal autologous cell therapy cardiac programs and ramp manufacturing activities for our allogenic cell therapy programs," said Peter Altman, Ph.D., BioCardia's CEO. (yahoo.com)
  • Recent results in the field have enhanced recognition for our technological and strategic approach to autologous cardiac cell therapy with the CardiAMP Cell Potency Assay to reduce patient variability, trial designs targeting patient populations sick enough to benefit greatly but not so ill that comorbidities drive outcomes, and the use of our leading Helix transendocardial biotherapeutic delivery system for enhanced dosage efficiency. (yahoo.com)
  • CardiAMP autologous and Neurokinin-1 Receptor Positive allogenic cell therapies are the Company's biotherapeutic platforms in clinical development. (yahoo.com)
  • Based on these results, we believe that DCP acts as an autologous mitogen for HCC cell lines. (labome.org)
  • These cells were cultured in RPMI 1640 supplemented with 10% heat-inactivated FBS, 2 mM l -glutamine, 100 U/ml penicillin, 100 μg/ml streptomycin, nonessential amino acids, sodium pyruvate, 10 ng/ml murine stem cell factor (SCF), and 10 ng/ml murine IL-3 (both from PeproTech). (jimmunol.org)
  • Neurokinin B (NKB) belongs in the family of tachykinin peptides. (wikipedia.org)
  • Neurokinin B along with its sister peptides of the KNDy subpopulation regulate this feedback. (wikipedia.org)
  • Dipeptidyl peptidase-4 (DPP4) is a ubiquitously expressed cell surface protease that preferentially cleaves dipeptides from the amino terminus of peptides containing a penultimate alanine or proline. (ahajournals.org)
  • An immunoevasive action was the initial normal behavior of the viral protein, in order to avail for the virus to spread to other cells by simply merging them with the infected one. (wikipedia.org)
  • Reproductive function is highly dependent on levels of both neurokinin B and also the G-protein coupled receptor ligand kisspeptin. (wikipedia.org)
  • Fluorescence resonance energy transfer (FRET), the technique of preference in this work, is used to measure ligand-protein and protein-protein interactions in living cells. (epfl.ch)
  • Vinculin, a plasma protein, links fibers to talin, which is a cell membrane protein. (medscape.com)
  • In their study in Nature Nanotechnology , researchers at NYU College of Dentistry, Monash University, Columbia University, and the University of Santiago in Chile focused on a G protein-coupled receptor called the neurokinin 1 receptor. (brightsurf.com)
  • The scna protein transports calcium ions into cells to the hav. (roanokechowan.edu)
  • CLIP f displays faster kinetics in in vitro labeling and fast, specific and efficient labeling in live and fixed cell applications, thereby rendering it a desired research tool for analysis of protein dynamics. (neb.com)
  • Recent studies suggested that cell apoptosis and autophagy might play key roles in acupuncture therapy. (hindawi.com)
  • Therefore, we searched PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI), aiming to find the potential relationship between acupuncture and cell apoptosis and autophagy. (hindawi.com)
  • These findings demonstrated that acupuncture has a potential role in modulating cell apoptosis and autophagy in animal models, suggesting it as a candidate mechanism in acupuncture therapy to maintain physiologic homeostasis. (hindawi.com)
  • Apoptosis and autophagy are two important cellular processes which control cell survival or death [ 4 ] and are also considered as a balanced response to pathogens and other immune stimuli that play an important role in maintaining physiologic homeostasis [ 5 ]. (hindawi.com)
  • However, there are few effective and safe ways to regulate cell apoptosis and autophagy in clinical practice right now. (hindawi.com)
  • Based on recent studies, the mechanism of acupuncture to treat medical disorders has a high degree of overlap with cell apoptosis and autophagy, which may provide a new direction for the clinical application and basic research. (hindawi.com)
  • Up to now, there has been no review to clarify the potential relationship between acupuncture and cell apoptosis and autophagy. (hindawi.com)
  • Herein, we performed a review, in particular focused on the therapy of acupuncture, including design method, acupoints selection, acupuncture intervention measure, and related diseases, trying to find out the detailed mechanism and objective evidence for modulation of acupuncture on cell apoptosis and autophagy. (hindawi.com)
  • REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer. (labome.org)
  • The specific antitumor action of L-732,138 occurred through the NK-1 receptor and melanoma cell death was by apoptosis. (mdpi.com)
  • Overexpression of a constitutively active PAK mutant (PAK1-T423E) promoted cell survival of FL5.12 and NIH 3T3 cells, while overexpression of the autoinhibitory domain of PAK (amino acids 83 to 149) enhanced apoptosis. (asm.org)
  • The ability of multicellular organisms to maintain cellular homeostasis is critically dependent on a balance between cell survival and cell death (apoptosis). (asm.org)
  • The deduced amino acid sequence of neurokinin A is as follows: His Lys Asp Ser Phe Val Gly Leu Met (HKTDSFVGLM) with amidation at the C-terminus. (wikipedia.org)
  • In an effort to specifically stimulate cells rather than kill them we have conjugated the neuropeptide substance P to the catalytic subunit of cholera toxin (SP-CTA). (sigmaaldrich.com)
  • We hypothesized that UCP2 could also regulate mast cell activation. (jimmunol.org)
  • Our results suggest that UCP2 can regulate mast cell activation. (jimmunol.org)
  • Despite the increasing importance of mast cells in regulating immune processes ( 4 ), little is still known about how mast cell activation is regulated. (jimmunol.org)
  • Both mitochondrial and cytosolic ROS are produced by mast cell activation ( 6 ). (jimmunol.org)
  • Studies on Neurokinin Antagonists. (nih.gov)
  • We hypothesized that elevated levels of neurokinin B may be an indicator of pre-eclampsia and that treatment with certain neurokinin receptor antagonists may be useful in alleviating the symptoms. (pubmedcentralcanada.ca)
  • Major pharmaceutical companies had programs to develop neurokinin receptor antagonists for chronic diseases, including pain and depression. (brightsurf.com)
  • TLR3-induced activation of mast cells modulates CD8 + T-cell recruitment. (nature.com)
  • The principal costimulatory signal is transmitted by CD80 or CD86 on APC to the CD28 receptor on T cells, which amplifies TCR activation signals ( 4 ). (aacrjournals.org)
  • Recently, we found DC-HIL to inhibit T-cell activation by binding syndecan-4 (SD-4) on activated (but not resting) T cells in mice and humans ( 19 - 21 ). (aacrjournals.org)
  • Unlike other known coinhibitors of T-cell activation, DC-HIL/Gpnmb is expressed constitutively and abundantly by mouse melanoma lines, a finding that prompted us to question whether DC-HIL/Gpnmb on melanoma provides resistance to immunologic recognition and destruction by melanoma-reactive T cells. (aacrjournals.org)
  • Our results indicate that DC-HIL/Gpnmb promotes the growth of B16F10 melanoma in syngeneic mice by inhibiting the activation of tumor-reactive T cells, thereby making the DC-HIL/SD-4 pathway a potentially useful target for antimelanoma immunotherapy. (aacrjournals.org)
  • Studies using AlF4-, an agent that can directly activate G proteins, and Ro31-8220 suggested that PKC can exert inhibitory effects 'downstream' of receptor activation, although immunoprecipitation of the G proteins alpha q/alpha 11 demonstrated that they do not undergo phosphorylation in UC11 cells and are unlikely to be the target of PKC-mediated inhibitory feedback. (wmin.ac.uk)
  • However, none of these studies have addressed the question of why the β-arrestin-bound, internalized receptor would be required for activation of ERK1/2 when other signals transduced by the receptor occur while it is still at the cell surface. (rupress.org)
  • p21-activated kinase 1 (PAK1) is activated by IL-3 in FL5.12 cells, and this activation is reduced by the phosphatidylinositol 3-kinase inhibitor LY294002. (asm.org)
  • Interstitial cells of Cajal (ICC) are a fundamental component of the pacemaker apparatus of the gastrointestinal (GI) tract. (semanticscholar.org)
  • The importance of interstitial cells of cajal in the gastrointestinal tract. (biomedsearch.com)
  • Furthermore, these PPTB-immunoreactive projections were confirmed by the double-fluorescence method after anterograde tracer injection into the ventral striatum containing the cell clusters. (nih.gov)
  • Both the percentage of SP expression in the population and mean fluorescence intensity (MFI) of SP expression were elevated in CD8 + T cells in the blood of AD patients. (biomedcentral.com)
  • This delay is required for preparatory cellular changes prior to rapid cell movement. (medscape.com)
  • Importantly, the influence of FLS cells on DRG neurones is dependent on their state of activity, and soluble factors as well as direct cellular contacts are crucial for their interaction with neurones. (biomedcentral.com)
  • This observation was backed in the baboon model where induction of endometriosis had not been connected with a significant upsurge in %Compact disc56+ cells Obatoclax mesylate inhibitor database in the mid-secretory eutopic endometrial Obatoclax mesylate inhibitor database examples weighed against pre-inoculation control examples. (neurokinin-receptor.info)
  • ii) a 2- fold higher affinity than paclitaxel (iii) 2.5-fold more potent than paclitaxel as an inhibitor of cell replication and (iv) docetaxel acts at the S-phase whereas paclitaxel at the G2 / M phases of the cell cycle. (eurekaselect.com)
  • activated mast cells also de novo synthesize numerous proinflammatory eicosanoids and cytokines, many of which can be released selectively ( 2 ). (jimmunol.org)
  • Optimal management of patients with germ cell tumors requires effective multidisciplinary management with medical oncology, urology, and in some instances, radiation oncology, working as a team. (renalandurologynews.com)
  • The fusion of the cells is apparently caused by viral fusion proteins from endosymbiotic endogenous retrovirus (ERV). (wikipedia.org)
  • The major sources of all of the proteins investigated immunohistochemically in sections of wisdom teeth were odontoblasts, cementoblasts and cell colonies in the pulpal mesenchyme. (wikiversity.org)
  • Using fluorescently tagged proteins combined with resonance energy transfer and image cross-correlation spectroscopy approaches, we show in live cells that β2-adaptin phosphorylation is an important regulatory process for the dissociation of β-arrestin-AP-2 complexes in CCPs. (biologists.org)
  • CLIP-tag and SNAP-tag ® can be used for orthogonal and complementary labeling of two proteins simultaneously in the same cells. (neb.com)
  • Bad is a critical regulatory component of the intrinsic cell death machinery that exerts its death-promoting effect upon heterodimerization with the antiapoptotic proteins Bcl-2 and Bcl-x L . Growth factors promote cell survival through phosphorylation of Bad, resulting in its dissociation from Bcl-2 and Bcl-x L and its association with 14-3-3τ. (asm.org)
  • Members of the Bcl-2 family are intracellular proteins that can either promote survival (Bcl-2, Bcl-x L , Mcl-1, and A1) or augment cell death (Bad, Bax, Bak, and Bcl-x S ) ( 38 , 41 ). (asm.org)
  • Bcl-2 family proteins homo- and heterodimerize, and it has been suggested that susceptibility to cell death is dictated by the relative levels and interactions of Bcl family members ( 57 ). (asm.org)
  • Innate immune cells include circulating cells, such as monocytes, dendritic cells, neutrophils, eosinophils, basophils, natural killer (NK) cells, invariant natural killer T (iNKT) cells and platelets, along with tissue-resident macrophages and mast cells. (haematologica.org)
  • Here we review the evidence for a contribution of innate immune cells to the pathophysiology of SCD. (haematologica.org)
  • Still, the placental barrier is not the sole means to evade the immune system, as foreign fetal cells also persist in the maternal circulation, on the other side of the placental barrier. (wikipedia.org)
  • Other examples of insufficient immune tolerance in pregnancy are Rh disease and pre-eclampsia: Rh disease is caused by the mother producing antibodies (including IgG antibodies) against the Rhesus D antigen on her baby's red blood cells. (wikipedia.org)
  • NK cells are part of the immune system and protect the body from viruses and tumours. (www.nhs.uk)
  • During this assessment, a blood sample was taken so the researchers could look at the activity of immune cells in the sample. (www.nhs.uk)
  • Blood samples were tested to determine the HIV viral load of each woman (the severity of infection with the virus) and to check the levels and function of different white blood cells, including NK cells, that make up the immune system. (www.nhs.uk)
  • Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming. (peprotech.com)
  • Folate-conjugated liposomes target and deliver therapeutics to immune cells in a rat model of rheumatoid arthritis. (purdue.edu)
  • What information is suggestive of an extremely premature infants, infants with transient subclinical or mild to moderate ad, is a vesicant, and is often low as that used for neuropsychiatric symptoms in these patients must be included in the peripheral smear lymphocytosis with small, matureappearing cells suggestive of. (roanokechowan.edu)
  • DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells. (peprotech.com)
  • Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells. (peprotech.com)
  • Poly I: C-activated dendritic cells that were generated in CellGro for use in cancer immunotherapy trials. (peprotech.com)
  • 9 Mononuclear cells from SCD patients also show increased production of superoxide anions, which may be explained by the upregulation of NADPH oxidase components in SCD mono-cytes. (haematologica.org)
  • CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. (rndsystems.com)
  • American Journal of Respiratory Cell & Molecular Biology , 46 (5), 566-572. (otago.ac.nz)
  • Trainees in the research laboratories learn a wide variety of molecular biology and cell biology techniques that are applied to the study of skin disorders. (mcw.edu)
  • Subtractive cDNA cloning of dendritic APCs (DC) led us to discover DC-HIL, a highly glycosylated (95-120 kDa) type I transmembrane receptor expressed constitutively at high levels by many APC subsets and at lower levels by some nonlymphoid cells ( 14 ). (aacrjournals.org)
  • Total RNA (1 μg) isolated from B16F10 cells or DCs was converted to cDNA by reverse transcriptase (Life Technologies, Inc. (aacrjournals.org)
  • Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. (perkinelmer.com.cn)
  • Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays. (perkinelmer.com)