Erythropoiesis: The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.Erythroblasts: Immature, nucleated ERYTHROCYTES occupying the stage of ERYTHROPOIESIS that follows formation of ERYTHROID PRECURSOR CELLS and precedes formation of RETICULOCYTES. The normal series is called normoblasts. Cells called MEGALOBLASTS are a pathologic series of erythroblasts.Erythropoietin: Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.Erythroid Precursor Cells: The cells in the erythroid series derived from MYELOID PROGENITOR CELLS or from the bi-potential MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS which eventually give rise to mature RED BLOOD CELLS. The erythroid progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E); BFU-E differentiate into CFU-E on stimulation by ERYTHROPOIETIN, and then further differentiate into ERYTHROBLASTS when stimulated by other factors.Erythroid Cells: The series of cells in the red blood cell lineage at various stages of differentiation.Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.Phenylhydrazines: Diazo derivatives of aniline, used as a reagent for sugars, ketones, and aldehydes. (Dorland, 28th ed)Hematopoiesis, Extramedullary: The formation and development of blood cells outside the BONE MARROW, as in the SPLEEN; LIVER; or LYMPH NODES.Receptors, Erythropoietin: Cell surface proteins that bind erythropoietin with high affinity and trigger intracellular changes influencing the behavior of cells.Erythrocyte Count: The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.Polycythemia: An increase in the total red cell mass of the blood. (Dorland, 27th ed)GATA1 Transcription Factor: A GATA transcription factor that is specifically expressed in hematopoietic lineages and plays an important role in the CELL DIFFERENTIATION of ERYTHROID CELLS and MEGAKARYOCYTES.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.beta-Thalassemia: A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.Iron: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.Hemoglobins: The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Hematocrit: The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.Reticulocyte Count: The number of RETICULOCYTES per unit volume of BLOOD. The values are expressed as a percentage of the ERYTHROCYTE COUNT or in the form of an index ("corrected reticulocyte index"), which attempts to account for the number of circulating erythrocytes.Iron Isotopes: Stable iron atoms that have the same atomic number as the element iron, but differ in atomic weight. Fe-54, 57, and 58 are stable iron isotopes.Reticulocytes: Immature ERYTHROCYTES. In humans, these are ERYTHROID CELLS that have just undergone extrusion of their CELL NUCLEUS. They still contain some organelles that gradually decrease in number as the cells mature. RIBOSOMES are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic "reticulum" (not the same as the ENDOPLASMIC RETICULUM), hence the name reticulocytes.Yolk Sac: The first of four extra-embryonic membranes to form during EMBRYOGENESIS. In REPTILES and BIRDS, it arises from endoderm and mesoderm to incorporate the EGG YOLK into the DIGESTIVE TRACT for nourishing the embryo. In placental MAMMALS, its nutritional function is vestigial; however, it is the source of INTESTINAL MUCOSA; BLOOD CELLS; and GERM CELLS. It is sometimes called the vitelline sac, which should not be confused with the VITELLINE MEMBRANE of the egg.Anemia, Hemolytic: A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Colony-Forming Units Assay: A cytologic technique for measuring the functional capacity of stem cells by assaying their activity.Hepcidins: Forms of hepcidin, a cationic amphipathic peptide synthesized in the liver as a prepropeptide which is first processed into prohepcidin and then into the biologically active hepcidin forms, including in human the 20-, 22-, and 25-amino acid residue peptide forms. Hepcidin acts as a homeostatic regulators of iron metabolism and also possesses antimicrobial activity.Globins: A superfamily of proteins containing the globin fold which is composed of 6-8 alpha helices arranged in a characterstic HEME enclosing structure.Receptors, Transferrin: Membrane glycoproteins found in high concentrations on iron-utilizing cells. They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released.Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Reticulocytosis: An increase in circulating RETICULOCYTES, which is among the simplest and most reliable signs of accelerated ERYTHROCYTE production. Reticulocytosis occurs during active BLOOD regeneration (stimulation of red bone marrow) and in certain types of ANEMIA, particularly CONGENITAL HEMOLYTIC ANEMIA.Anemia, Macrocytic: Anemia characterized by larger than normal erythrocytes, increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH).Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Hematopoiesis: The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).beta-Globins: Members of the beta-globin family. In humans, they are encoded in a gene cluster on CHROMOSOME 11. They include epsilon-globin, gamma-globin, delta-globin and beta-globin. There is also a pseudogene of beta (theta-beta) in the gene cluster. Adult HEMOGLOBIN is comprised of two ALPHA-GLOBIN chains and two beta-globin chains.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Bloodletting: Puncture of a vein to draw blood for therapeutic purposes. Bloodletting therapy has been used in Talmudic and Indian medicine since the medieval time, and was still practiced widely in the 18th and 19th centuries. Its modern counterpart is PHLEBOTOMY.Fetal Hemoglobin: The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.alpha-Globins: Members of the alpha-globin family. In humans, they are encoded in a gene cluster on CHROMOSOME 16. They include zeta-globin and alpha-globin. There are also pseudogenes of zeta (theta-zeta) and alpha (theta-alpha) in the cluster. Adult HEMOGLOBIN is comprised of 2 alpha-globin chains and 2 beta-globin chains.Anemia, Diamond-Blackfan: A rare congenital hypoplastic anemia that usually presents early in infancy. The disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (Curr Opin Hematol 2000 Mar;7(2):85-94)Spleen: An encapsulated lymphatic organ through which venous blood filters.Erythrocyte Aging: The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.Iron Radioisotopes: Unstable isotopes of iron that decay or disintegrate emitting radiation. Fe atoms with atomic weights 52, 53, 55, and 59-61 are radioactive iron isotopes.Erythroid-Specific DNA-Binding Factors: A group of transcription factors that were originally described as being specific to ERYTHROID CELLS.Anemia, Hypochromic: Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393)Glycophorin: The major sialoglycoprotein of the human erythrocyte membrane. It consists of at least two sialoglycopeptides and is composed of 60% carbohydrate including sialic acid and 40% protein. It is involved in a number of different biological activities including the binding of MN blood groups, influenza viruses, kidney bean phytohemagglutinin, and wheat germ agglutinin.Anemia, Dyserythropoietic, Congenital: A familial disorder characterized by ANEMIA with multinuclear ERYTHROBLASTS, karyorrhexis, asynchrony of nuclear and cytoplasmic maturation, and various nuclear abnormalities of bone marrow erythrocyte precursors (ERYTHROID PRECURSOR CELLS). Type II is the most common of the 3 types; it is often referred to as HEMPAS, based on the Hereditary Erythroblast Multinuclearity with Positive Acidified Serum test.Leukemia, Erythroblastic, Acute: A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.Hemoglobin E: An abnormal hemoglobin that results from the substitution of lysine for glutamic acid at position 26 of the beta chain. It is most frequently observed in southeast Asian populations.Polycythemia Vera: A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.Hematinics: Agents which improve the quality of the blood, increasing the hemoglobin level and the number of erythrocytes. They are used in the treatment of anemias.Antimicrobial Cationic Peptides: Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.Ferritins: Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types.Anemia, Iron-Deficiency: Anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. The erythrocytes are hypochromic and microcytic and the iron binding capacity is increased.Phlebotomy: The techniques used to draw blood from a vein for diagnostic purposes or for treatment of certain blood disorders such as erythrocytosis, hemochromatosis, polycythemia vera, and porphyria cutanea tarda.GATA2 Transcription Factor: An essential GATA transcription factor that is expressed primarily in HEMATOPOIETIC STEM CELLS.Stem Cell Factor: A hematopoietic growth factor and the ligand of the cell surface c-kit protein (PROTO-ONCOGENE PROTEINS C-KIT). It is expressed during embryogenesis and is a growth factor for a number of cell types including the MAST CELLS and the MELANOCYTES in addition to the HEMATOPOIETIC STEM CELLS.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Transferrin: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.K562 Cells: An ERYTHROLEUKEMIA cell line derived from a CHRONIC MYELOID LEUKEMIA patient in BLAST CRISIS.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Mice, Inbred C57BLThrombopoiesis: The process of generating thrombocytes (BLOOD PLATELETS) from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via the MEGAKARYOCYTES. The humoral factor with thrombopoiesis-stimulating activity is designated THROMBOPOIETIN.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Erythrocyte Indices: ERYTHROCYTE size and HEMOGLOBIN content or concentration, usually derived from ERYTHROCYTE COUNT; BLOOD hemoglobin concentration; and HEMATOCRIT. The indices include the mean corpuscular volume (MCV), the mean corpuscular hemoglobin (MCH), and the mean corpuscular hemoglobin concentration (MCHC).gamma-Globins: Members of the beta-globin family. In humans, two non-allelic types of gamma-globin - A gamma and G gamma are encoded in the beta-globin gene cluster on CHROMOSOME 11. Two gamma-globin chains combine with two ZETA-GLOBIN chains to form the embryonic hemoglobin Portland. Fetal HEMOGLOBIN F is formed from two gamma-globin chains combined with two ALPHA-GLOBIN chains.Basic Helix-Loop-Helix Transcription Factors: A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Iron Overload: An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Pregnanes: Saturated derivatives of the steroid pregnane. The 5-beta series includes PROGESTERONE and related hormones; the 5-alpha series includes forms generally excreted in the urine.Fetus: The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.Antigens, CD34: Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.Megakaryocytes: Very large BONE MARROW CELLS which release mature BLOOD PLATELETS.Blood Cell Count: The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.Splenomegaly: Enlargement of the spleen.SOXD Transcription Factors: A subclass of closely-related SOX transcription factors. In addition to a conserved HMG-BOX DOMAIN, members of this group contain a leucine zipper motif which mediates protein DIMERIZATION.Myelopoiesis: Formation of MYELOID CELLS from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via MYELOID STEM CELLS. Myelopoiesis generally refers to the production of leukocytes in blood, such as MONOCYTES and GRANULOCYTES. This process also produces precursor cells for MACROPHAGE and DENDRITIC CELLS found in the lymphoid tissue.Anemia, Sideroblastic: Anemia characterized by the presence of erythroblasts containing excessive deposits of iron in the marrow.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Anemia, Megaloblastic: A disorder characterized by the presence of ANEMIA, abnormally large red blood cells (megalocytes or macrocytes), and MEGALOBLASTS.Anemia, Aplastic: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.Kruppel-Like Transcription Factors: A family of zinc finger transcription factors that share homology with Kruppel protein, Drosophila. They contain a highly conserved seven amino acid spacer sequence in between their ZINC FINGER MOTIFS.Anemia, Refractory: A severe sometimes chronic anemia, usually macrocytic in type, that does not respond to ordinary antianemic therapy.Blood Transfusion: The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)Embryo, Mammalian: The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.Chromium Isotopes: Stable chromium atoms that have the same atomic number as the element chromium, but differ in atomic weight. Cr-50, 53, and 54 are stable chromium isotopes.Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.Stress, Physiological: The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions.Megaloblasts: Red blood cell precursors, corresponding to ERYTHROBLASTS, that are larger than normal, usually resulting from a FOLIC ACID DEFICIENCY or VITAMIN B 12 DEFICIENCY.Red-Cell Aplasia, Pure: Suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.STAT5 Transcription Factor: A signal transducer and activator of transcription that mediates cellular responses to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such as BCL-2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID LEUKEMIA.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Anoxia: Relatively complete absence of oxygen in one or more tissues.Janus Kinase 2: A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.Hematopoietic System: The blood-making organs and tissues, principally the bone marrow and lymph nodes.Bone Morphogenetic Protein 4: A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.Hematopoietic Cell Growth Factors: These growth factors comprise a family of hematopoietic regulators with biological specificities defined by their ability to support proliferation and differentiation of blood cells of different lineages. ERYTHROPOIETIN and the COLONY-STIMULATING FACTORS belong to this family. Some of these factors have been studied and used in the treatment of chemotherapy-induced neutropenia, myelodysplastic syndromes, and bone marrow failure syndromes.Iron Compounds: Organic and inorganic compounds that contain iron as an integral part of the molecule.LIM Domain Proteins: A large class of structurally-related proteins that contain one or more LIM zinc finger domains. Many of the proteins in this class are involved in intracellular signaling processes and mediate their effects via LIM domain protein-protein interactions. The name LIM is derived from the first three proteins in which the motif was found: LIN-11, Isl1 and Mec-3.Thalassemia: A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Doping in Sports: Illegitimate use of substances for a desired effect in competitive sports. It includes humans and animals.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.I Blood-Group System: A blood group related both to the ABO and P systems that includes several different antigens found in most people on erythrocytes, in milk, and in saliva. The antibodies react only at low temperatures.Erythrocytes, Abnormal: Oxygen-carrying RED BLOOD CELLS in mammalian blood that are abnormal in structure or function.Embryo Loss: Early pregnancy loss during the EMBRYO, MAMMALIAN stage of development. In the human, this period comprises the second through eighth week after fertilization.
... it stimulates red blood cell production (erythropoiesis) in the bone marrow. Low levels of EPO (around 10 mU/mL) are constantly ... Erythropoietin is an essential hormone for red blood cell production. Without it, definitive erythropoiesis does not take place ... is produced by recombinant DNA technology in cell culture and are collectively called erythropoiesis-stimulating agents (ESA): ... by promoting their survival through protecting these cells from apoptosis, or cell death. Erythropoietin is the primary ...
Erythropoietin in neuroprotection
Epo controls erythropoiesis, or red blood cell production. Erythropoietin and its receptor were thought to be present in the ... In Schwann cells, increased erythropoietin levels may stimulate Schwann cell proliferation via JAK2 and ERK/MAP kinase ... Cell culture models show that retinal ganglion cells can be prevented from dying by certain pharmacological treatments. ... Similar to stimulation of red blood cell precursor cells (erythrogenesis), erythropoietin stimulates non-differentiated Schwann ...
T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene. The protein encoded by ... "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357-66. doi:10.1038/sj. ... Cell. Biol. 10 (12): 6426-35. PMC 362919 . PMID 2247063. Chen Q, Cheng JT, Tasi LH, Schneider N, Buchanan G, Carroll A, Crist W ... Cell. Biol. 20 (6): 2248-59. doi:10.1128/mcb.20.6.2248-2259.2000. PMC 110841 . PMID 10688671. Lécuyer E, Herblot S, Saint-Denis ...
It stimulates erythropoiesis (increases red blood cell levels) by the same mechanism as rHuEpo (binding and activating the Epo ... It is an erythropoiesis-stimulating 165-amino acid protein. Use of darbepoetin alfa is contraindicated in patients with ... Darbepoetin is produced by recombinant DNA technology in modified Chinese hamster ovary cells. It differs from endogenous ... Darbepoetin alfa binds to the erythropoietin receptor on erythroid progenitor cells, stimulating RBC production and ...
"MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells". Mol Cell. 37 (5): 620-32 ... "Expression of microRNA-451 in normal and thalassemic erythropoiesis". Ann Hematol. 89 (10): 953-8. doi:10.1007/s00277-010-0980- ... Godlewski J, Bronisz A, Nowicki MO, Chiocca EA, Lawler S (2010). "microRNA-451: A conditional switch controlling glioma cell ... Bruchova-Votavova H, Yoon D, Prchal JT (2010). "miR-451 enhances erythroid differentiation in K562 cells". Leuk Lymphoma. 51 (4 ...
Cell. Biol. 18 (2): 846-58. PMC 108796 . PMID 9447981. Gamou T, Kitamura E, Hosoda F, Shimizu K, Shinohara K, Hayashi Y, Nagase ... "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357-66. doi:10.1038/sj. ... Cell. Biol. 21 (19): 6470-83. doi:10.1128/mcb.21.19.6470-6483.2001. PMC 99794 . PMID 11533236. Goardon N, Lambert JA, Rodriguez ...
"SOCS3 is essential in the regulation of fetal liver erythropoiesis". Cell. 98 (5): 617-27. doi:10.1016/S0092-8674(00)80049-5. ... Cell Biol. 3 (5): 460-5. doi:10.1038/35074525. PMID 11331873. Lena AM, Shalom-Feuerstein R, Rivetti di Val Cervo P, Aberdam D, ... Cell Biol. 3 (5): 460-5. doi:10.1038/35074525. PMID 11331873. Roberts AW, Robb L, Rakar S, Hartley L, Cluse L, Nicola NA, ... Genes Cells. 4 (6): 339-51. doi:10.1046/j.1365-2443.1999.00263.x. PMID 10421843. Marine JC, McKay C, Wang D, Topham DJ, ...
"MicroRNA expression profiling during human cord blood-derived CD34 cell erythropoiesis". Exp. Hematol. 35 (4): 551-64. doi: ... Mir-22 was originally identified in HeLa cells (an immortal cell line derived from cervical cancer cells), but was later found ... Expression of miR-22 can be induced by adding 12-O-Tetradecanoylphorbol-13-acetate (TPA) to HL-60 cells (leukaemia cell line). ... Li J, Liang S, Yu H, Zhang J, Ma D, Lu X (2010). "An inhibitory effect of miR-22 on cell migration and invasion in ovarian ...
Franz Ernst Christian Neumann
He demonstrated that erythropoiesis and leukopoiesis formulate in the bone marrow. "Ernst Neumann postulated a common stem cell ... Cell Stem Cell 1, July 2007, p.37: Ernst Neumann (1912) and others began to use the term stem cell to refer to the common ... "It is evident, that a continuing transformation of lymphoid cells into coloured blood cells takes place in the bone marrow ... Legend of the stem cell-picture: Draft by Ernst Neumann himself, showing the "great-lymphozyt-stem-cell" (1912) or "great- ...
Mir-154 microRNA precursor family
"MicroRNA expression profiling during human cord blood-derived CD34 cell erythropoiesis". Experimental Hematology. 35 (4): 551- ... Debernardi, S.; Dixon-Mciver, A. (2010). "MicroRNA Detection in Bone Marrow Cells by LNA-FISH". MicroRNAs and the Immune System ... "Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue". Clinical Cancer Research. 14 (9): 2588- ... "Differential MicroRNA Expression in Peripheral Blood Mononuclear Cells from Graves' Disease Patients". Journal of Clinical ...
Mir-185 microRNA precursor family
"MicroRNA expression profiling during human cord blood-derived CD34 cell erythropoiesis". Experimental Hematology. 35 (4): 551- ... "MiR-107 and MiR-185 Can Induce Cell Cycle Arrest in Human Non Small Cell Lung Cancer Cell Lines". PLoS ONE. 4 (8): e6677. doi: ... With application to clear cell Renal Cell Carcinoma". BMC Systems Biology. 4: 51. doi:10.1186/1752-0509-4-51. PMC 2876063 . ... "Regulation of Cancer Aggressive Features in Melanoma Cells by MicroRNAs". PLoS ONE. 6 (4): e18936. doi:10.1371/journal.pone. ...
"Identification of a human heme exporter that is essential for erythropoiesis". Cell. 118 (6): 757-66. doi:10.1016/j.cell. ... "A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily ... Blood Cells Mol. Dis. 35 (2): 189-92. doi:10.1016/j.bcmd.2005.01.005. PMID 15996880. Brown JK, Fung C, Tailor CS (2006). " ... a retrovirus that induces red cell aplasia". Blood. 95 (3): 1093-9. PMID 10648427. "Entrez Gene: FLVCR feline leukemia virus ...
Mir-32 microRNA precursor family
"MicroRNA expression profiling during human cord blood-derived CD34 cell erythropoiesis". Experimental Hematology. 35 (4): 551- ... "MiR-148 Regulates Mitf in Melanoma Cells". PLoS ONE. 5 (7): e11574. doi:10.1371/journal.pone.0011574. PMC 2904378 . PMID ... 25-Dihydroxyvitamin D3 in Human Myeloid Leukemia Cells Leads to Bim Targeting and Inhibition of AraC-Induced Apoptosis". Cancer ... "MiR-93 suppresses proliferation and colony formation of human colon cancer stem cells". World Journal of Gastroenterology. 17 ( ...
... which are the precursor cells to all types of blood cells, or primordial germ cells (PGCs), the precursor to cells passed on in ... "Mammalian homeobox B6 expression can be correlated with erythropoietin production sites and erythropoiesis during development, ... HOX B6 gene is only expressed in erythoid progenitor cells, which are the precursor to red blood cells used for transport of ... An oncoprotein can cause the transformation of a normal cell into a tumor cell. Overexpression of HOXB6, along with the ...
... embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis. Erythroid Krüppel-like Factor (EKLF or KLF1 ... T-cells are activated and more prone to apoptosis without KLF2, suggesting that KLF2 regulates T-cell quiescence and survival. ... and Myc control a regulatory network essential for embryonic erythropoiesis". Mol. Cell. Biol. 32 (13): 2628-44. doi:10.1128/ ... but it is also expressed temporally during embryogenesis in erythroid cells, endothelium, lymphoid cells, the spleen, and white ...
Hence SBDS is critical for normal erythropoiesis. This family is highly conserved in species ranging from archaea to ... Knockdown of SBDS expression results in increased apoptosis in erythroid cells undergoing differentiation due to elevated ROS ... is critical for normal erythropoiesis". Blood. 118 (24): 6407-17. doi:10.1182/blood-2011-02-335190. PMID 21963601. Savchenko A ...
Mir-24 microRNA precursor family
"miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA ... January 2008). "MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4". Blood. 111 (2): 588-95. doi ... "miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration". The Journal of Cell Biology. 199 ( ... Recently, miR-24 has been shown to suppress expression of two crucial cell cycle control genes, E2F2 and Myc in hematopoietic ...
Latent iron deficiency
... is present but red blood cell appearance remains normal. Changes in the appearance of red blood cells are the hallmark of stage ... Erythropoiesis impairment begins when the serum iron level falls to less than 50 μg/dL and transferrin saturation is less than ... Stage 2 - Erythropoiesis is impaired. In spite of an increased level of transferrin, serum iron level is decreased along with ... Latent iron deficiency (LID), also called iron-deficient erythropoiesis, is a medical condition in which there is evidence of ...
... plays a key role in areas where erythropoiesis and active cell division occur. The receptor helps maintain iron ... The main role of transferrin is to deliver iron from absorption centers in the duodenum and white blood cell macrophages to all ... The receptor with its ligand bound transferrin is then transported through the endocytic cycle back to the cell surface, ready ... Transferrin and its receptor have been shown to diminish tumour cells when the receptor is used to attract antibodies. ...
Vascular endothelial growth factor
... cancer cells, kidney epithelial cells). In vitro, VEGF-A has been shown to stimulate endothelial cell mitogenesis and cell ... HIF stimulates the release of VEGF-A, among other functions (including modulation of erythropoiesis). Circulating VEGF-A then ... VEGF-A production can be induced in cell that is not receiving enough oxygen. When a cell is deficient in oxygen, it produces ... "Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells". Biochemical ...
At this time several developing blood cell lines are available, like erythropoiesis and thrombopoiesis. The granulopoiesis is ... The wall of the sinuses is composed of two different types of cells, the endothelial cells and the adventitial reticular cells ... These cells descend from the primitive reticulum cells, which are found in the stroma of the marrow. There is also an ... There is a progressive accumulation of leukemic cells, because some blast progenitor cells renew themselves and will have a ...
DNA damage-inducible transcript 3
"Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C". Mol Cell ... and the ribosomal protein FTE/S3a modulates erythropoiesis". J. Biol. Chem. 275 (11): 7591-6. doi:10.1074/jbc.275.11.7591. PMID ... Cell. Biol. 16 (3): 1157-68. doi:10.1128/MCB.16.3.1157. PMC 231098 . PMID 8622660. Ubeda M, Vallejo M, Habener JF (November ... Cell. Biol. 19 (11): 7589-99. PMC 84780 . PMID 10523647. Hattori T, Ohoka N, Hayashi H, Onozaki K (April 2003). "C/EBP ...
2003). "Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family". Exp. Cell Res. 282 (2 ... Cell. Endocrinol. 225 (1-2): 109-18. doi:10.1016/j.mce.2004.07.009. PMID 15451575. Dias Neto E, Correa RG, Verjovski-Almeida S ... Cell. Endocrinol. 218 (1-2): 129-35. doi:10.1016/j.mce.2003.12.019. PMID 15130517. Zhang Z, Henzel WJ (2005). "Signal peptide ... sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells". J. Clin. Endocrinol. Metab. ...
"Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants". Blood. 127 (15 ... Cell. Biol. 22 (1): 161-70. doi:10.1128/mcb.22.1.161-170.2002. PMC 134232 . PMID 11739731. Perkins, Andrew; Sharpe, Ariene; ... KLF1 coordinates the regulation of six cellular pathways that are all essential to terminal erythroid differentiation: Cell ... cells. The molecule has two domains; the transactivation domain and the chromatin-remodeling domain. The carboxyl (C) terminal ...
... leukemic cells to healthy B cells and promote their transformation to tumorigenic-like cells Selection of competent B cells ... During myelopoeisis further cellular differentiation takes place including thrombopoiesis, erythropoeisis, granulopoeisis, and ... that was specific for hematopoietic cells including B-cells, T-cells, monocytes and granulocytes. Together these results ... Activated B and T cells show increased miR-155 expression, the same goes for macrophages and dendritic cells of the immune ...
... and mast cell differentiation. miR-223 down-regulation during erythropoiesis is required for erythrocyte proliferation and ... Cell. 129 (3): 617-31. doi:10.1016/j.cell.2007.02.048. PMID 17482553. Sun G, Li H, Rossi JJ (2010). "Sequence context outside ... Cell. 123 (5): 819-31. doi:10.1016/j.cell.2005.09.023. PMID 16325577. Sugatani T, Hruska KA (2007). "MicroRNA-223 is a key ... "MicroRNA-223 reversibly regulates erythroid and megakaryocytic differentiation of K562 cells". J Cell Mol Med. 13 (11-12): 4551 ...
Methoxy polyethylene glycol-epoetin beta
The drug stimulates erythropoiesis by interacting with the erythropoietin receptor on progenitor cells in the bone marrow. It ... It is the first approved, chemically modified erythropoiesis-stimulating agent (ESA). Mircera is supplied as a solution in pre- ... PEGylation Macdougall, Iain C; Eckardt, Kai-Uwe (2006). "Novel strategies for stimulating erythropoiesis and potential new ...
This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. ... Cell. 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. JARID1A protein, human at the US National Library of ... Knockdown of JARID1A promoted osteogenic differentiation of human adipose-derived stromal cells in vitro and in vivo and ... Mao S, Neale GA, Goorha RM (Apr 1997). "T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2". Oncogene ...
Reticulocytes are less efficient at carrying oxygen as mature red cells, and they are less deformable, causing impaired transit ... As the bone marrow increases erythropoiesis, the systemic reticulocyte count and the risk for hyperviscosity syndrome increases ... High red blood cell count Swollen or clubbed finger tips (clubbing) Fainting (also known as syncope) Heart failure Abnormal ... resulting in a compensatory increase in erythropoietin production and an increased production of red blood cells in an attempt ...
1996). "DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability". Nat. Genet ... Ligase I has also been found to be upregulated in proliferating tumor cells, as opposed to benign tumor cell lines and normal ... "Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells". Cell Res. 18 (1): 27-47. ... Although the N-terminus of the peptide has no catalytic activity it is needed for activity within the cells. The N-terminus of ...
ଜଣ୍ଡିସ୍ - ଉଇକିପିଡ଼ିଆ
ଲୋହିତ ରକ୍ତ କଣିକା ନିଜର ଜୀବନକାଳ(୧୨୦ ଦିନ) ସମାପ୍ତ କରିସାରିଲେ ବା କୌଣସି କାରଣରୁ ନଷ୍ଟ ହେଲେ ତାହାର କୋଷ ପରଦା(cell membrane) ଭଙ୍ଗୁର ହୋଇ ... erythropoiesis) ଅନ୍ୟ ହେମ ଥିବା ପ୍ରୋଟିନ ଯେପରିକି ମାୟୋଗ୍ଲୋବିନ ଓ ସାଇଟୋକ୍ରୋମ । ... ଅଧିକ ଅନକଞ୍ଜୁଗେଟେଡ ବିଲିରୁବିନ ହେବାର କାରଣ: ହେମୋଲାଇଟିକ ଆନିମିଆ (excess red blood cell breakdown), ବିରାଟ ଅଧଃକ୍ଷତ (large bruise), ...
When plasmin breaks down fibrin, a number of soluble parts are produced. These are called fibrin degradation products (FDPs). FDPs compete with thrombin, and thus slow down clot formation by preventing the conversion of fibrinogen to fibrin. This effect can be seen in the thrombin clotting time (TCT) test, which is prolonged in a person that has active fibrinolysis.. FDPs, and a specific FDP, the D-dimer, can be measured using antibody-antigen technology. This is more specific than the TCT, and confirms that fibrinolysis has occurred. It is therefore used to indicate deep-vein thrombosis, pulmonary embolism, DIC and efficacy of treatment in acute myocardial infarction. Alternatively, a more rapid detection of fibrinolytic activity, especially hyperfibrinolysis, is possible with thromboelastometry (TEM) in whole blood, even in patients on heparin. In this assay, increased fibrinolysis is assessed by comparing the TEM profile in the absence or presence of the fibrinolysis inhibitor aprotinin. ...
Innate immune system
Rather, NK cells destroy compromised host cells, such as tumor cells or virus-infected cells, recognizing such cells by a ... Mast cells. Main article: Mast cell. Mast cells are a type of innate immune cell that reside in connective tissue and in ... Natural killer cells. Main article: Natural killer cell. Natural killer cells (NK cells) are a component of the innate ... γδ T cells. Main article: gamma/delta T cells. Like other 'unconventional' T cell subsets bearing invariant T cell ...
Eritropoetin - Wikipédia
1957) „Role of the kidney in erythropoiesis". Nature 179 (4560), 633-4. o. DOI:10.1038/179633a0. PMID 13418752. ... 2007) „Does erythropoietin have a dark side? Epo signaling and cancer cells". Science's STKE 2007 (395), pe38. o. DOI:10.1126/ ... 2012) „The effect of erythropoietin on normal and neoplastic cells". Biologics 6, 163-89. o. DOI:10.2147/BTT.S32281. PMID ... 1996) „Erythropoietin production by interstitial cells of hypoxic monkey kidneys". British Journal of Haematology 95 (1), 27-32 ...
cell-cell signaling. • ephrin receptor signaling pathway. • axon guidance. • osteoclast differentiation. • bone remodeling. ... especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are ... Cells. 9 (4): 440-5. PMID 10515610.. *. Aasheim HC, Munthe E, Funderud S, et al. (2000). "A splice variant of human ephrin-A4 ... Eph Nomenclature Committee". Cell. 90 (3): 403-4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.. ...
Red blood cell
Human red blood cells are produced through a process named erythropoiesis, developing from committed stem cells to mature red ... Red blood cells, also known as RBCs, red cells, red blood corpuscles, haematids, erythroid cells or erythrocytes (from Greek ... Red blood cells of mammals cells have nuclei during early phases of erythropoiesis, but extrude them during development as they ... Red blood cells in mammals anucleate when mature, meaning that they lack a cell nucleus. In comparison, the red blood cells of ...
Since folate deficiency limits cell division, erythropoiesis, production of red blood cells, is hindered and leads to ... Folate is required to make red blood cells and white blood cells and folate deficiency may lead to anemia, which causes fatigue ... Folate is important for cells and tissues that divide rapidly. Cancer cells divide rapidly, and drugs that interfere with ... Folate deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of ...
මානව කායිකවේදය - විකිපීඩියා, නිදහස් විශ්වකෝෂය
As each red blood cell traverses through the reticuloendothelial system, its cell membrane ruptures when its membrane is ... However approximately 20 percent comes from other heme sources, including ineffective erythropoiesis, and the breakdown of ... breakdown of red blood cells). Unconjugated bilirubin comes from the breakdown of the heme pigment found in red blood cells' ... When red blood cells have completed their life span of approximately 120 days, or when they are damaged, their membranes become ...
RBCs are formed in the red bone marrow from hematopoietic stem cells in a process known as erythropoiesis. In adults, about 2.4 ... A blood cell, also called a hematopoietic cell, hemocyte, or hematocyte, is a cell produced through hematopoiesis and found ... Red blood cells are the most abundant cell in the blood, accounting for about 40-45% of its volume. Red blood cells are disk- ... "Blood Cells" redirects here. For the journal formerly known as Blood Cells, see Blood Cells, Molecules and Diseases. ...
In the maturation of the red blood cell lineage (see erythropoiesis) from mitochondria-bearing reticulocytes to mature ... Statins also inhibit PPARγ in human macrophages, vascular endothelial cells, and smooth muscle cells; this action may ... and export of the 13-OXO-glutathione conjugate in HT-29 cells". Biochimica et Biophysica Acta (BBA) - Molecular and Cell ... this receptor is highly expressed in mouse and human airway epithelial cells and in Beas 2B human airway epithelial cells and, ...
위키백과:미번역 문서/의학 - 위키백과, 우리 모두의 백과사전
Folate also aids in erythropoiesis, the production of red blood cells. ... It is essential in the production of blood cells in bone marrow, and for nerve sheaths and proteins. Vitamin B12 functions ... B vitamins are a class of water-soluble vitamins that play important roles in cell metabolism. Though these vitamins share ... Vitamin B14: cell proliferant, anti-anemia, rat growth factor, and antitumor pterin phosphate, named by Earl R. Norris. ...
Sakit na sickle-cell, ang malayang ensiklopedya
At krisis na ito ay normal na pinapagana ng parvovirus B19 na direktang umaapekto sa erythropoiesis sa pamamagitan ng pagsakop ... Ang sakit na sickle-cell (SCD), o sickle-cell anaemia (SCA) o drepanocytosis ay isang namamanang diperensiya sa dugo na ... Ang Sickle-cell anaemia ay isang anyo ng sakit na sickle-cell kung saan may homozygosity para sa mutasyon na nagsasanhi ng HbS ... Kung saan ang malaria ay karaniwan, ang pagdadala ng isang gene ng sickle cell(katangiang sickle cell) ay nagbibigay pag-akma ...
Harold M. Weintraub
Weintraub, H; Campbell Gle, M; Holtzer, H (1971). "Primitive erythropoiesis in early chick embryogenesis. I. Cell cycle ... The effects of bromodeoxyuridine on cell differentiation (conversion of a primitive cell into a more specialized cell) were ... Zhuang, Y; Soriano, P; Weintraub, H (1994). "The helix-loop-helix gene E2A is required for B cell formation". Cell. 79 (5): 875 ... This work included the study of cell cycle kinetics, hemoglobin synthesis, and the control of cell division. ...
Iron is present in all cells in the human body and has several vital functions, such as carrying oxygen to the tissues from the ... or iron-deficient erythropoiesis (IDE). ... Hemoglobin binds to oxygen, enabling red blood cells to supply ... which is taken up by cells by endocytosing transferrin, thus preventing its access to bacteria. Between 15 and 20 percent ... Anemia is a condition characterized by inadequate red blood cells (erythrocytes) or hemoglobin. When the body lacks sufficient ...
WHO Model List of Essential Medicines
It stimulates erythropoiesis (production of red blood cells) in the bone marrow. Calcitriol, the activated form of vitamin D, ... Interstitial kidney cells. Gene and protein expression. Further information: Bioinformatics § Gene and protein expression ... Filtration, which takes place at the renal corpuscle, is the process by which cells and large proteins are retained while ... About 20,000 protein coding genes are expressed in human cells and almost 70% of these genes are expressed in normal, adult ...
... is required for the stimulation of erythropoiesis (i.e. increase in red blood cell formation) in response to stress and 2 ... cell-cell signaling. • embryonic hemopoiesis. • cell development. • positive regulation of erythrocyte differentiation. • ... particularly red blood cells and platelets but also eosinophils, basophils, mast cells, and dendritic cells. The knock-out mice ... myeloid cell differentiation. • negative regulation of apoptotic process. • homeostasis of number of cells within a tissue. • ...
Anemia of chronic disease
This effect may be an important additional cause for the decreased erythropoiesis and red blood cell production seen in anemia ... Bone marrow produces both white blood cells and red blood cells from the same precursor stem cells. Therefore, the upregulation ... of white blood cells causes fewer stem cells to differentiate into red blood cells. ... the effect of locking up iron stores is to reduce the ability of the bone marrow to produce red blood cells. These cells ...
Obesity hypoventilation syndrome
Endothelial cell injury. Any inflammatory process, such as trauma, surgery or infection, can cause damage to the ... Erythropoiesis-stimulating agents.  Acute medical illness.  Inflammatory bowel disease.  ... Instead, the platelet-derived growth factor degranulated by the clotted platelets will attract a layer of smooth muscle cells ... The main causes of thrombosis are given in Virchow's triad which lists thrombophilia, endothelial cell injury, and disturbed ...
The alpha and beta cells are the endocrine cells in the pancreatic islets that release insulin and glucagon and smaller amounts ... diminished erythropoiesis in chronic renal failure), or structural enlargement in a critical site such as the thyroid (toxic ... The ability of a target cell to respond to a hormone depends on the presence of receptors, within the cell or on its plasma ... Interaction of hormones at target cells Permissiveness is the situation in which a hormone cannot exert its full effects ...
... regeneration of red blood cells via erythropoiesis occurs through the maturation of erythrocytes from hematopoietic stem cells ... Macrophages are a type of repairing cell that devour dead cells and pathogens, and trigger other immune cells to respond to ... First, adult cells de-differentiate into progenitor cells which will replace the tissues they are derived from. Second ... "Cell. 153 (6): 1219-1227. doi:10.1016/j.cell.2013.05.002. PMC 4394608 . PMID 23746839.. ...
Erythrocytes mature through erythropoiesis in the bone marrow, where they lose their nuclei, organelles, and ribosomes. The ... Anucleated cells. Human red blood cells, like those of other mammals, lack nuclei. This occurs as a normal part of the cells' ... At a certain point during the cell cycle in open mitosis, the cell divides to form two cells. In order for this process to be ... Other multinucleate cells in the human are osteoclasts a type of bone cell. Multinucleated and binucleated cells can also be ...
... it stimulates erythropoiesis (increasing red blood cell levels) and is used to treat anemia, commonly associated with chronic ... Epoetin alfa (rINN) /ɛˈpoʊ.ɪtɪn/ is a human erythropoietin produced in cell culture using recombinant DNA technology. ... "Information on Erythropoiesis Stimulating Agents (ESA) (marketed as Procrit, Epogen, and Aranesp)". U.S. Food and Drug ... "Erythropoiesis Stimulating Agents: Aranesp (darbepoetin alfa), Epogen (epoetin alfa), and Procrit (epoetin alfa)". MedWatch - ...
Hormones affect distant cells by binding to specific receptor proteins in the target cell resulting in a change in cell ... diminished erythropoiesis in chronic renal failure), or structural enlargement in a critical site such as the thyroid (toxic ... or protein components of a cell membrane, and may affect either the emitting cell or the immediately adjacent cells. ... Cell signallingEdit. The typical mode of cell signaling in the endocrine system is endocrine signaling, that is, using the ...
에리트로포이에틴 - 위키백과, 우리 모두의 백과사전
외인성 에리트로포이에틴(Exogenous EPO)이 신체 성능을 향상시키는 약물로 사용될때, erythropoiesis-stimulating agent (ESA)로 분류 되기도 한다. 외인성 에리트로포이에틴은 혈액에서 검출 될 ... Sytkowski AJ (2007). "Does erythropoietin have a dark side? Epo signaling and cancer cells". 《Sci. STKE》 2007 (395): e38. PMID ... Jacobson LO, Goldwasser E, Fried W, Plzak L (1957년 3월). "Role of the kidney in erythropoiesis". 《Nature》 179 (4560): 633-4. ... Fisher JW, Koury S, Ducey T, Mendel S (1996년 10월). "Erythropoietin production by interstitial cells of hypoxic monkey kidneys ...
Congenital dyserythropoietic anaemia: response to splenectomy and quantitation of ineffective erythropoiesis. | Journal of...
Regulation of red cell life-span, erythropoiesis, survival, senescence and clearance | Projects | H2020 | CORDIS | European...
Reduction in red blood cell (RBC) number can be caused by blood loss, diet, stress conditions including...,MSCA-ITN-2015-ETN, ... Regulation of red cell life-span, erythropoiesis, survival, senescence and clearance. Von 2015-09-01 bis 2019-08-31, Laufendes ... Periodic Reporting for period 1 - RELEVANCE (Regulation of red cell life-span, erythropoiesis, survival, senescence and ... 3D tomography of cells in micro-channels Author(s): S. Quint, A. F. Christ, A. Guckenberger, S. Himbert, L. Kaestner, S. Gekle ...
MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation | PNAS
104 cells per mouse), together with γ-irradiated (2,000 cGy) CB CD34-accessory cells (1 × 106 cells per mouse). Mice were ... TF-1 cells transduced with miR 221 or 222 showed a reduced proliferative rate as compared with control cells (Fig. 5A Top). The ... CD34+ cells E culture. CD34+ cells were first incubated in E medium supplemented with KL for 24 h, and then transduced with a ... TF-1 erythroleukemic cell line. We investigated the effects of miR 221 and 222 in the kit+ TF-1 erythroleukemic cell line (Fig ...
JCI - The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice
The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. ... The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. ... To investigate the role of glial cells as a component of the systemic response to hypoxia, we created astrocyte-specific ... However, both neurons and astrocytes (the largest subpopulation of glial cells in the CNS) also express EPO following ischemic ...
Osteoclasts Are Required for Hematopoietic Stem and Progenitor Cell Mobilization but Not for Stress Erythropoiesis in...
... biological response modifiers and the family of cell adhesion-promoting molecules. ... erythroid cells (b), lineage− cells (c), and hematopoietic stem cells (d) by cytofluorometry. Data are mean ± SEM from 3 ... mast cells, and myeloid cells in calcitonin-treated mice, although decreased numbers of B cells were noticed. The exacerbated ... cells (c), and hematopoietic stem cells (e) by cytofluorometry. Identification panel of hematopoietic stem cells (Lineage-7AAD− ...
8/3- Stem Cell Hematopoiesis, Erythropoiesis & Marrow Failure Flashcards by Kathryn Kudlaty | Brainscape
Stem Cell Hematopoiesis, Erythropoiesis & Marrow Failure flashcards from Kathryn Kudlaty ... 8/3- Stem Cell Hematopoiesis, Erythropoiesis & Marrow Failure Flashcards Preview _MS2 HemeOnc , 8/3- Stem Cell Hematopoiesis, ... Drives erythropoeisis (increased RBC production). - Produced by interstitial renal tubular cells (about 10% produced by the ... Red cell destruction (or acute blood loss) decreases red cell mass and blood volume; decreased vascularity then triggers the ...
Increased Expression of Erythropoiesis Inhibiting Cytokines (IFN-γ, TNF-α, IL-10, and IL-13) by T Cells in Patients Exhibiting...
T Cell Activation Demonstrated at the Single Cell Level in the Three Subject Groups. Ex vivo T cell expression of cytokines was ... Cells were stimulated with PMA/ionomycin, and cell staining was carried out as described. The cells were stained for IFN-γ and ... cells were CD4+ T cells. The percentage of CD4 cells that were positive for a cytokine was determined as described for CD8. ... Increased Expression of Erythropoiesis Inhibiting Cytokines (IFN-γ, TNF-α, IL-10, and IL-13) by T Cells in Patients Exhibiting ...
Measurement of Anti-Erythropoiesis-Stimulating Agent IgG4 Antibody as an Indicator of Antibody-Mediated Pure Red Cell Aplasia |...
Measurement of Anti-Erythropoiesis-Stimulating Agent IgG4 Antibody as an Indicator of Antibody-Mediated Pure Red Cell Aplasia. ... Measurement of Anti-Erythropoiesis-Stimulating Agent IgG4 Antibody as an Indicator of Antibody-Mediated Pure Red Cell Aplasia ... Measurement of Anti-Erythropoiesis-Stimulating Agent IgG4 Antibody as an Indicator of Antibody-Mediated Pure Red Cell Aplasia ... Measurement of Anti-Erythropoiesis-Stimulating Agent IgG4 Antibody as an Indicator of Antibody-Mediated Pure Red Cell Aplasia ...
Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis. « Research...
Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.. by Robert ... Hematopoietic stem cell differentiation involves the silencing of self-renewal genes and induction of a specific ... Using a replicative primary human hematopoietic stem/progenitor cell differentiation system, we demonstrate dynamic changes of ... and disrupted 5-hmC patterning in leukemia patient-derived CD34+ stem/early progenitor cells with TET methylcytosine ...
Gelsolin is expressed in early erythroid progenitor cells and negatively regulated during erythropoiesis. | Journal of Cell...
Gelsolin is expressed in early erythroid progenitor cells and negatively regulated during erythropoiesis.. J Cell Biol 1 ... Gelsolin is expressed in early erythroid progenitor cells and negatively regulated during erythropoiesis. H Hinssen, H Hinssen ... Depending on either the presence of Ca2+ during cell lysis or on the preincubation of the intact cells with the Ca2+-ionophore ... to extend the meshwork of the spectrin-actin-based membrane skeleton in erythroid cells during erythropoiesis. ...
... : Making a Red Blood Cell. Cell differentiation along the erythroid lineage occurs over a two week span in humans ... Mature erythroblasts are smaller with a tightly compacted nucleus which is expelled as the cells become reticulocytes. Stages ... BFU-Es express the cell surface antigen, CD34, as do all other early hematopoietic progenitors allowing for its isolation using ... Cells were stained by the Romanowski water-based adaptation of Wright-Giemsa. ...
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. - PubMed - NCBI
Cell. 2000 Jul 21;102(2):221-31. Research Support, Non-U.S. Govt; Research Support, U.S. Govt, Non-P.H.S.; Research Support, ... Cell. 2000 Jul 21;102(2):221-31.. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in ... Inhibition of p38 activity also interferes with stabilization of Epo mRNA in human hepatoma cells undergoing hypoxic stress. ... The p38alpha MAP kinase plays a critical role linking developmental and stress-induced erythropoiesis through regulation of Epo ...
Daily variations of marrow and splenic erythropoiesis, pinna epidermal cell mitosis and physical activity in C57B1/6J mice<...
Daily variations of marrow and splenic erythropoiesis, pinna epidermal cell mitosis and physical activity in C57B1/6J mice. / ... Sharkis SJ, Palmer JD, Goodenough J. Daily variations of marrow and splenic erythropoiesis, pinna epidermal cell mitosis and ... Sharkis, S. J. ; Palmer, J. D. ; Goodenough, J. / Daily variations of marrow and splenic erythropoiesis, pinna epidermal cell ... T1 - Daily variations of marrow and splenic erythropoiesis, pinna epidermal cell mitosis and physical activity in C57B1/6J mice ...
Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis:...
... including CD34+ cells, correlating highly with the strength of the erythropoiesis signature. The erythropoiesis signature ... An erythropoiesis signature in active sJIA is associated with the expansion of CD34+ cells, also is seen in some patients with ... Patients with non-sJIA and anemia did not exhibit the erythropoiesis signature. The erythropoiesis signature was found to be ... The expansion of immature cells was most prominently seen in patients with sJIA and anemia, even in the absence of ...
Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin. - PubMed - NCBI
Number of Epo-expressing cells was counted in each renal cross-section and expressed as number of cells/mm2 (n = 3 each). (B) ... The black x indicates that the Epo gene in tubular epithelial cells (TEC) is not transcribed. The tilde indicates that Epo is ... The number of EPO-producing cells is reduced in P8;Vhlfl/fl Epofl/fl mutants. ... Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin.. Farsijani NM, Liu Q, Kobayashi H, ...
JCI - Loss of α-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates β-thalassemia
The half-life of wild-type red blood cells was 22 days, whereas that of the AHSP-/- red blood cells was 12 days. AHSP+/- ... Hematopoietic differentiation during embryonic stem cell differentiation in culture. Mol. Cell. Biol. 1993. 13:472-486. ... Percent mature cells = number of cells in d / (a + b + c + d); n = 6 animals for each genotype; **P , 0.05. (C-E) Detection of ... Single-cell suspensions were stained with PE-Ter119 and FITC-CD71 (BD Biosciences - Pharmingen). For exclusion of dead cells, 7 ...
Diverse of Erythropoiesis Responding to Hypoxia and Low Environmental Temperature in Vertebrates
Indeed, there is a wide range of variations in vertebrates erythropoiesis. This paper also focused on erythropoietic responses ... Therefore, it is considered that investigations of erythropoiesis in vertebrates provide a lead to the various erythropoietic ... Moreover, it has recently become increasingly clear that various environmental stresses could induce the erythropoiesis via ... This paper comparatively introduces the present understanding of erythropoiesis in vertebrates. ...
Molecular Biology of Erythropoiesis | SpringerLink
Expression of Homeobox Genes in Human Erythroleukemia Cells Wei-Fan Shen, Corey Largman, Patricia Lowney, Frank M. Hack, H. ... Erythropoiesis - Regulatory Aspects. * Tumor Necrosis Factor α and the Anemia of Chronic Disease: Effects of Chronic Exposure ... Its focus on erythropoiesis represents an attempt to cover a rapidly expanding field, which has gone from elegant studies of ... Heme Regulation and Erythropoiesis. * Studies of the Effect of Erythropoietin on Heme Synthesis ...
A Guide to Erythropoiesis - EPO Signaling and Erythroid Development
New Tools for the Ex Vivo Expansion of Human Hematopoietic Stem and Progenitor Cells. Publish Date: March 09, 2015 Views: 508 ... Webinar: A Guide to Erythropoiesis - EPO Signaling and Erythroid Development. . To view the webinar, please complete the form, ... Cytokines and Lineage Choice in Stem Cell Differentiation. Publish Date: May 13, 2010 Views: 140 ...
Characterization of the erythropoiesis in myelodysplasia by means of ferrokinetic studies, in vitro erythroid colony formation...
Bone Marrow Cells / pathology*. Cells, Cultured. Colony-Forming Units Assay. Erythropoiesis*. Erythropoietin / blood. ... Previous Document: Quality of IL-3 and G-CSF-mobilized peripheral blood stem cells in patients with early chronic phase.... ... Hematopoietic Stem Cells / pathology*, physiology. Humans. Leukocyte Count. Middle Aged. Platelet Count. Receptors, Transferrin ... Characterization of the erythropoiesis in myelodysplasia by means of ferrokinetic studies, in vitro erythroid colony formation ...
Unexpected role for p19INK4d in post-transcriptional regulation of GATA1 and modulation of human terminal erythropoiesis |...
Red Cell Physiology Laboratory, New York Blood Center, New York, NY, United States; ... Unexpected role for p19INK4d in post-transcriptional regulation of GATA1 and modulation of human terminal erythropoiesis. Xu ... Red Cell Physiology Laboratory, New York Blood Center, New York, NY, United States; ... Unexpectedly, p19INK4d knockdown did not affect cell cycle. Rather it led to decreased expression of GATA1 protein. Importantly ...
Differentiating Factors Between Erythropoiesis-Stimulating Agents | SpringerLink
Three of the four currently available erythropoiesis stimulating agents... ... Pure red-cell aplasia and recombinant erythropoietin [letter]. N Engl J Med 2002; 346: 1584-6PubMedCrossRefGoogle Scholar ... New insights into erythropoiesis. Curr Opin Hematol 2002; 9: 93-100PubMedCrossRefGoogle Scholar ... Novel erythropoiesis stimulating protein. Semin Nephrol 2000; 20: 375-81PubMedGoogle Scholar ...
Erythropoeisis | definition of Erythropoeisis by Medical dictionary
Erythropoeisis explanation free. What is Erythropoeisis? Meaning of Erythropoeisis medical term. What does Erythropoeisis mean? ... Looking for online definition of Erythropoeisis in the Medical Dictionary? ... erythropoiesis. Red cell production.. erythropoiesis. the formation of blood cells in bone marrow.. Erythropoiesis. The process ... erythropoiesis. formation of red blood cells. erythropoiesis (i·rith·rō·poiˑ·ē·sis),. n red blood cell production that occurs ...
Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis
Iron demand in bone marrow increases when erythropoiesis is stimulated by hypoxia via increased erythropoietin (EPO) synthesis ... Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis J Clin Invest. 2012 Dec;122(12):4635-44. ... Cell Line, Tumor * Erythropoiesis* * Erythropoietin / physiology* * Gene Expression * Gene Expression Regulation * Growth ... When erythropoiesis was inhibited pharmacologically, Hamp1 was no longer suppressed despite profound elevations in serum EPO, ...
Characterization of Erythropoiesis and Erythroid Cells. - Jeffery Miller
A major focus of the laboratory involves studies of erythropoiesis in real-time as stem cells undergo erythroid commitment and ... Characterization of Erythropoiesis and Erythroid Cells. Miller, Jeffery National Institute of Diabetes and Digestive and Kidney ... Characterization of Erythropoiesis and Erythroid Cells.. Miller, Jeffery / National Institute of Diabetes and Digestive and ... Characterization of Erythropoiesis and Erythroid Cells.. Miller, Jeffery / National Institute of Diabetes and Digestive and ...
Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C | Science Signaling
Tracing cell trajectories in a biofilm. *. Working Life. A child of the slums ... Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C. By Laura F. Bennett, Chang Liao, Michael ... Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C. By Laura F. Bennett, Chang Liao, Michael ... Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C Message Subject. (Your Name) has ...
SF3B1 KNOCKDOWN AT EARLY ERYTHROPOIESIS INDUCED CELL APOPTOSIS BY.... EHA Library. Huang Y. Jun 15 2019; 266845
SF3B1 KNOCKDOWN AT EARLY ERYTHROPOIESIS INDUCED CELL APOPTOSIS BY USING A TET-ON LENTIVIRAL VECTOR ... the deficiency of SF3B1 leads to significant cell apoptosis; however, it has no effect on cell growth at late stages of ... Undifferentiated CD34+ cells were transduced with the Lentivirus and SF3B1 gene knockdown was induced by doxycycline in ... However, the physiological roles of SF3B1 in erythropoiesis are poorly studied. Aims. To elucidate the biological functions of ...
Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis. - Nuffield...
Using a replicative primary human hematopoietic stem/progenitor cell differentiation system, we demonstrate dynamic changes of ... and disrupted 5-hmC patterning in leukemia patient-derived CD34+ stem/early progenitor cells with TET methylcytosine ... Hematopoietic stem cell differentiation involves the silencing of self-renewal genes and induction of a specific ... of multiple covalent cytosine modifications raises the question of how these derivatized bases influence stem cell commitment. ...
Erythropoiesis - Wikipedia
There are colony forming units that the cells follow during their formation. These cells are referred to as the committed cells ... erythropoiesis takes place in the mesodermal cells of the yolk sac. By the third or fourth month, erythropoiesis moves to the ... the production of red blood cells is equal to the destruction of red blood cells and the red blood cell number is sufficient to ... Loss of function of the erythropoietin receptor or JAK2 in mice cells causes failure in erythropoiesis, so production of red ...
Long non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development | Nature Communications
Here the authors reveal the role of lncRNA UCA1 in erythroid cell development. ... Differential UCA1 expression during human erythropoiesis. Human cord blood CD34+ progenitor cells were purified and subjected ... Cells were maintained at a density between 5 × 104 and 2 × 106 cells per ml, with medium changes every 3 to 4 days. Cells were ... After 48 h of lentivirus infection in K562 cells, the GFP and RFP double-positive cells were sorted as single cells using an ...
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis. | Sigma-Aldrich
Cell death and differentiation 2015-1-24 Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B ... Erythroid and B-cell development may be particularly vulnerable to Ant2 depletion-mediated mitochondrial dysfunction and ... Ant2 depletion caused anemia in a cell-autonomous manner by maturation arrest of erythroid precursors with increased reactive ... and splenocytes showed a reduction in maximal respiration capacity and cellular ATP levels as well as an increase in cell death ...
Ineffective erythropoiesisBoneBlood cellErythropoietinDifferentiationStress erythropoiesisProgenitorTerminal erythropoiesisIneffectiveHematopoiesisHumansTreatment with erythropoiesis-stimulRegulationVitroDefinitiveRegulatesSplenicHypoxiaInduceAnaemiaMetabolismMyelodysplastic SyndromesBiologyCD34AdultProliferationSurvivalApoptosisMiceBiolPathwayOxygenRBCsMyelopoiesisHSCsSpleenMacrophagesPure red celSuppressesRenalVitamin B12
- Congenital dyserythropoietic anemia (CDA) is a rare group of red blood cell disorders characterized by ineffective erythropoiesis and increased iron absorption. (ru.nl)
- To determine whether growth differentation factor 15 (GDF15) hyper-expression is associated with the ineffective erythropoiesis and iron-loading complications of CDA type I (CDA I), GDF15 levels and other markers of erythropoiesis and iron overload were studied in blood from 17 CDA I patients. (ru.nl)
- Association of red blood cell distribution width (RDW) with mortality in the Third National Health and Nutrition Examination Survey (NHANES III). (jamanetwork.com)
- Tonelli MSacks FArnold MMoye LDavis BPfeffer MCholesterol and Recurrent Events (CARE) Trial Investigators, Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. (jamanetwork.com)
- Does Erythropoietin Regulate TRPC Channels in Red Blood Cells? (europa.eu)
- A key adaptation to environmental hypoxia is an increase in erythropoiesis, driven by the hormone erythropoietin (EPO) through what is traditionally thought to be primarily a renal response. (jci.org)
- Using FACScan flow cytometry, the proportion of PMA/ionomycin-stimulated T cells expressing cytokines ex vivo was compared in 18 poor responders to erythropoietin, 14 good responders to erythropoietin, and 14 normal controls. (asnjournals.org)
- Anemia is a major complication of end-stage renal disease (ESRD), occurring primarily as a result of reduced erythropoietin production from the peritubular cells of the kidney ( 1 ). (asnjournals.org)
- Patients treated with erythropoietin-based erythropoiesis-stimulating agents (ESAs) can develop a rare but life-threatening condition called antibody-mediated pure red cell aplasia (amPRCA). (asm.org)
- Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. (nih.gov)
- Whereas some p38alpha(-/-) embryos die between embryonic days 11.5 and 12.5, those that develop past this stage have normal morphology but are anemic owing to failed definitive erythropoiesis, caused by diminished erythropoietin (Epo) gene expression. (nih.gov)
- Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin. (nih.gov)
- The adult kidney plays a central role in erythropoiesis and is the main source of erythropoietin (EPO), an oxygen-sensitive glycoprotein that is essential for red blood cell production. (nih.gov)
- Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. (springer.com)
- Differentiation and erythropoietin receptor gene expression in human erythroid progenitor cells. (springer.com)
- n red blood cell production that occurs in bone marrow and involves maturation of nucleated precursors into erythrocytes regulated by the hormone erythropoietin produced in the kidneys. (thefreedictionary.com)
- Iron demand in bone marrow increases when erythropoiesis is stimulated by hypoxia via increased erythropoietin (EPO) synthesis in kidney and liver. (nih.gov)
- A feedback loop involving erythropoietin helps regulate the process of erythropoiesis so that, in non-disease states, the production of red blood cells is equal to the destruction of red blood cells and the red blood cell number is sufficient to sustain adequate tissue oxygen levels but not so high as to cause sludging, thrombosis, or stroke. (wikipedia.org)
- Garlic accelerates red blood cell turnover and splenic erythropoietic gene expression in mice: evidence for erythropoietin-independent erythropoiesis. (duke.edu)
- Thus, garlic consumption not only causes increased energy demand from the faster RBC turnover but also increases the production of CO, which in turn stimulates splenic erythropoiesis by an erythropoietin-independent mechanism, thus completing the sequence of feedback regulation for RBC metabolism. (duke.edu)
- Erythropoietin is a hormone produced in the kidney, which increases the production of red blood cells. (cochrane.org)
- Experiments were performed to test the hypothesis that rats could be made permanently anemic by repeated mixed gamma-neutron irradiations, and that once the maintenance of normal circulatory red cell concentration was lost, the administration of exogenous erythropoietin could not restore the production of red cells to normal levels. (dtic.mil)
- This study indicates that murine foetal erythropoiesis is regulated by erythropoietin in the same way as later in life. (biologists.org)
- Exogenous erythropoietin, recombinant human erythropoietin (rhEPO) is produced by recombinant DNA technology in cell culture and are collectively called erythropoiesis-stimulating agents (ESA): two examples are epoetin alfa and epoetin beta. (wikipedia.org)
- Erythropoietin is an essential hormone for red blood cell production. (wikipedia.org)
- Under hypoxic conditions, the kidney will produce and secrete erythropoietin to increase the production of red blood cells by targeting CFU-E, proerythroblast and basophilic erythroblast subsets in the differentiation. (wikipedia.org)
- Erythropoietin has its primary effect on red blood cell progenitors and precursors (which are found in the bone marrow in humans) by promoting their survival through protecting these cells from apoptosis, or cell death. (wikipedia.org)
- The burst-forming unit-erythroid (BFU-E) cells start erythropoietin receptor expression and are sensitive to erythropoietin. (wikipedia.org)
- Precursors of red cells, the proerythroblasts and basophilic erythroblasts also express erythropoietin receptor and are therefore affected by it. (wikipedia.org)
- Erythropoietin was reported to have a range of actions beyond stimulation of erythropoiesis including vasoconstriction-dependent hypertension, stimulating angiogenesis, and promoting cell survival via activation of EPO receptors resulting in anti-apoptotic effects on ischemic tissues. (wikipedia.org)
- EPO binds to the erythropoietin receptor on the red cell progenitor surface and activates a JAK2 signaling cascade. (wikipedia.org)
- High level erythropoietin receptor expression is localized to erythroid progenitor cells. (wikipedia.org)
- In the bloodstream, red cells themselves do not express erythropoietin receptor, so cannot respond to EPO. (wikipedia.org)
- Treatment with erythropoiesis-stimulating agents (ESAs) has been used as a pharmacologic strategy when the blunted response of endogenous erythropoietin has been reported in critically-ill people. (cochrane.org)
- He later conducted important research on the formation of blood cells, studying the regulatory hormone erythropoietin, and the process of hemopoiesis, the formation of blood cells. (uchicago.edu)
- QGR significantly increased the cell viability of BMNCs even in hypoxic condition, and mRNA expressions of stem cell factor, granulocyte macrophage-colony stimulating factor and erythropoietin from bone marrow stromal cells. (pharmalicensing.com)
- In mammals, hypoxia-triggered erythropoietin release increases red blood cell mass to meet tissue oxygen demands. (sigmaaldrich.com)
- This is possible because erythropoietin is present in the central nervous system, because erythropoiesis-secreting tissues are widely distributed in humans, and because erythropoiesis receptors are expressed in human neurons, glia cells, astrocytes, and cerebral endothelial cells, they wrote. (medpagetoday.com)
- The JAK2 V617F point mutation makes the normal hematopoietic progenitor cells hypersensitive to thrombopoietin, erythropoietin, and myeloid progenitor cells, leading to trilinear hematopoietic myeloproliferation. (qxmd.com)
- During anemia erythropoiesis is bolstered by several factors including KIT ligand, oncostatin-M, glucocorticoids, and erythropoietin. (semanticscholar.org)
- For many years bone marrow anoxia was thought to stimulate erythropoiesis, but there is growing acceptance of the belief that a hormone, erythropoietin, provides the marrow with the immediate stimulus for blood production. (annals.org)
- ESAs work like the human protein erythropoietin, which stimulates bone marrow to make red blood cells. (ascopost.com)
- Cell Death and Differentiation, issue 24/9, 2017. (europa.eu)
- Functional studies show that treatment of CD34+ progenitors with miR 221 and 222, via oligonucleotide transfection or lentiviral vector infection, causes impaired proliferation and accelerated differentiation of E cells, coupled with down-modulation of kit protein: this phenomenon, observed in E culture releasing endogenous kit ligand, is magnified in E culture supplemented with kit ligand. (pnas.org)
- We have performed genomewide expression profiling of miRs ( 11 ) in the human hematopoietic lineages, as evaluated in unilineage differentiation/maturation culture of cord blood (CB) CD34+ hematopoietic progenitor cells (HPCs). (pnas.org)
- Hematopoietic stem cell differentiation involves the silencing of self-renewal genes and induction of a specific transcriptional program. (igsb.org)
- Using a replicative primary human hematopoietic stem/progenitor cell differentiation system, we demonstrate dynamic changes of 5-hydroxymethylcytosine (5-hmC) during stem cell commitment and differentiation to the erythroid lineage. (igsb.org)
- The functional importance of 5-hmC was demonstrated by impaired erythroid differentiation, with augmentation of myeloid potential, and disrupted 5-hmC patterning in leukemia patient-derived CD34+ stem/early progenitor cells with TET methylcytosine dioxygenase 2 (TET2) mutations. (igsb.org)
- Thus, chemical conjugation and affinity purification of 5-hmC-enriched sequences followed by sequencing serve as resources for deciphering functional implications for gene expression during stem cell commitment and differentiation along a particular lineage. (igsb.org)
- Cell differentiation along the erythroid lineage occurs over a two week span in humans. (upenn.edu)
- Terminal erythroid differentiation is tightly coordinated with cell cycle exit, which is regulated by cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors (CDKI), yet their roles in erythropoiesis remain to be fully defined. (bloodjournal.org)
- We show here that p19 INK4d , a member of CDKI family, is abundantly expressed in erythroblasts and that p19 INK4d knockdown delayed erythroid differentiation, inhibited cell growth, led to increased apoptosis and generation of abnormally nucleated late stage erythroblasts. (bloodjournal.org)
- A major focus of the laboratory involves studies of erythropoiesis in real-time as stem cells undergo erythroid commitment and differentiation. (grantome.com)
- Undifferentiated CD34+ cells were transduced with the Lentivirus and SF3B1 gene knockdown was induced by doxycycline in different differentiation stages across human erythropoiesis. (ehaweb.org)
- This hormone stimulates proliferation and differentiation of red cell precursors, which activates increased erythropoiesis in the hemopoietic tissues, ultimately producing red blood cells (erythrocytes). (wikipedia.org)
- In stem and progenitor cells, Bach2 and Bach1 were found to promote lymphoid cell differentiation by restricting the expression of myeloid transcription factors as well as their target genes important for myeloid cell differentiation. (nii.ac.jp)
- The RTN will generate a comprehensive molecular description of mechanisms governing erythropoiesis, from specification of hematopoietic stem cells in embryogenesis to terminal differentiation and post-mitotic maturation of red blood cels. (europa.eu)
- Vitamin A is involved in regulating the growth and specialization ( differentiation ) of virtually all cells in the human body. (oregonstate.edu)
- This results in differentiation, survival and proliferation of the erythroid cell. (wikipedia.org)
- Platelet assembly and release are the final events of a multi-step process involving commitment, proliferation and differentiation of hematopoietic stem cells (HSC) to megakaryocytes (MK). (sanquin.nl)
- Recent advances in the area of stem cell research suggest that redirected differentiation of stem cells may prove useful for the treatment of a variety of diseases including diabetes and other systemic diseases. (clinicaltrials.gov)
- In the hematopoietic system, recent studies have also demonstrated the ability of adult erythroid stem cells to undergo differentiation toward a fetal-like phenotype. (clinicaltrials.gov)
- In addition, it is clear that the stem cells from separate donors do not possess identical properties of growth and differentiation. (clinicaltrials.gov)
- The cells will then be studied in-depth for a better understanding of their biological properties, growth and differentiation. (clinicaltrials.gov)
- The molecular and cellular biological pathways involved in erythroid cell differentiation. (nih.gov)
- This includes not only adult or definitive erythropoiesis (differentiation), but also ontological or primitive erythropoiesis (development). (nih.gov)
- Our study establishes a mechanism for regulating tissue cell fate and differentiation through transcription elongation. (nih.gov)
- TNFα is also a potent activator of the sphingomyelinase (SMase)/ceramide pathway leading to ceramide synthesis and regulating cell differentiation, proliferation, apoptosis, senescence, and autophagy. (inpst.net)
- Analysis of cell morphology and colony formation demonstrated that erythropoiesis impairment was concomitant with a granulomonocytic differentiation in TNFα- and ceramide-treated EpoCD34/HSPCs. (inpst.net)
- Inhibition of erythropoiesis and induction of granulomonocytic differentiation were correlated to modulation of hematopoietic transcription factors (TFs) GATA-1, GATA-2, and PU.1. (inpst.net)
- We have therefore identified, for the first time, distinct gene expression dynamics during erythroblast differentiation from hiPSCs which may cause reduced proliferation and enucleation of hiPSC-derived erythroid cells. (ox.ac.uk)
- Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. (uniprot.org)
- Our group has identified at least three target sequence areas and one putative splicing factor involved in tissue-specific regulation of red cell isoforms during erythroid differentiation. (dana-farber.org)
- Moreover, as cells approach the state of terminal differentiation, there is a clear shift from the intranuclear localization of protein 4.1R to peripheral localization. (dana-farber.org)
- Current studies are pursuing the hypothesis that this complex shift in localization and association is indicative of a role for protein 4.1R in signaling terminal differentiation and initiating shutdown of cell proliferation and division. (dana-farber.org)
- These stem cells are dependent on vitamin A for differentiation into red blood cells. (livestrong.com)
- Globally, our results indicate that although osteoclast-dependent HSC mobilization from bone marrow to spleen is triggered in murine blood stage malaria, this activity is not essential for stress erythropoiesis. (hindawi.com)
- Stress Erythropoiesis. (nih.gov)
- Epo, stem cell factor, GATA-1, are also required for stress erythropoiesis, it is generally believed that the latter is controlled by additional and distinct molecular networks. (haematologica.org)
- In erythropoietic (E) culture of cord blood CD34+ progenitor cells, the level of miR 221 and 222 is gradually and sharply down-modulated. (pnas.org)
- In accord with this, erythroid progenitor cells and reticulocytes were substantially reduced in number in mice lacking HIF function in astrocytes following hypoxic stress. (jci.org)
- The activity of osteoclasts seems required for the mobilization of hematopoietic stem and progenitor cells (HSPC) from the bone marrow to the periphery. (hindawi.com)
- Recent studies involve bone resorbing osteoclasts in the homeostasis and mobilization of HSC and hematopoietic progenitor cells (HSPC) in conditions of stress, although this function remains controversial [ 8 - 11 ]. (hindawi.com)
- Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis. (igsb.org)
- Gelsolin is expressed in early erythroid progenitor cells and negatively regulated during erythropoiesis. (rupress.org)
- From quantitations of its steady-state molar ratio to actin, gelsolin is abundant in early progenitor cells as revealed from avian erythroblastosis virus- and S13 virus-transformed cells which are arrested at the colony forming unit erythroid (CFU-e) stage of erythroid development. (rupress.org)
- This down regulation is independent from that of actin, which is considerably less, and is observed also when S13-transformed erythroid progenitor cells are induced to differentiate under conditions where the actin content of these cells does not change. (rupress.org)
- The following stages of development all occur within the bone marrow: A Hemocytoblast, a multipotent hematopoietic stem cell, becomes a common myeloid progenitor or a multipotent stem cell, and then a unipotent stem cell, then a pronormoblast, also commonly called an proerythroblast or a rubriblast. (wikipedia.org)
- We show for the first time that the analyzed conformational mutations lead to higher cell viability in human hematopoietic stem progenitor cells. (oncotarget.com)
- Both hematopoietic cells and cells that form the hematopoietic stem and progenitor cell niche have been identified as targets of GvHD. (wiley.com)
- We previously developed a lentiviral system that allows us to over-express and knock-down MEIS1 in human hematopoietic stem and progenitor cells. (sanquin.nl)
- The harvested product will be purified for the primitive hematopoietic progenitor cells and viably preserved in multiple aliquots. (clinicaltrials.gov)
- BMNCs including hematopoietic stem cells (HSCs), early progenitor cells (EPCs), stromal cells and other precursor cells were isolated from femurs and tibias of 8 to 12-week-old male C57BL/6 mice. (pharmalicensing.com)
- Talving and colleagues explained that in TBI, ESAs may mediate anti-inflammatory and anti-apoptotic responses, and also may enhance angiogenic properties by recruiting endothelial progenitor cells in brain tissue. (medpagetoday.com)
- Here we evaluated the implication of the TNFα/SMase/ceramide pathway on inhibition of erythropoiesis in human CD34+ hematopoietic stem/progenitor cells (CD34/HSPCs) from healthy donors. (inpst.net)
- Orsini M, Chateauvieux S, Rhim J, Gaigneaux A, Cheillan D, Christov C, Dicato M, Morceau F, Diederich M. Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells . (inpst.net)
- DYRK3 is restricted to erythroid progenitor cells and testes. (semanticscholar.org)
- It has been proposed that during embryonic development haematopoietic cells arise from a mesodermal progenitor with both endothelial and haematopoietic potential called the haemangioblast 1 , 2 . (nature.com)
- 17 , 18 , 20 Since the ability of these special progenitor cells to respond to stress depends on cues from the microenvironment (ME) of the spleen rather than the bone marrow (BM), distinct erythroid cell/ME interactions are apparently at play in the former but not the latter environment under stress. (haematologica.org)
- Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells. (jove.com)
- Furthermore, terminal erythropoiesis has been reported to take place in a specialized microenvironment called the erythroblastic island. (frontiersin.org)
- Protein 4.1R Exon 16 3' Splice Site Activation Requires Coordination among TIA1, Pcbp1, and RBM39 during Terminal Erythropoiesis. (dana-farber.org)
- These observations demonstrate that different patterns of defects can be observed in the erythropoiesis of RA and RARS patients whereby normal to increased ETU levels and the presence of cytogenetic abnormalities differentiate between cases of RA with ineffective erythropoiesis associated with regular transfusions and cases who are relatively transfusion independent. (biomedsearch.com)
- This condition is characterized by ineffective erythropoeisis , bone-marrow expansion, and rapid destruction of erythrocytes. (thefreedictionary.com)
- We found that, at homeostasis, β1-deficient mice have a modest uncompensated anemia with ineffective erythropoiesis and decreased red blood cell survival. (haematologica.org)
- Which lab results are characteristic of ineffective erythropoiesis (ELB production) in unconjugated hyperbilirubinemia? (medscape.com)
- Ineffective erythropoiesis (ELB production) is characterized by a marked increase in fecal urobilinogen excretion and a normal or near-normal red blood cell lifespan. (medscape.com)
- While the thalassemia syndromes are heterogeneous, including homozygous or compound heterozygous β-globin defects, the pathophysiology is primarily related to ineffective erythropoiesis and systemic iron overload with tissue iron deposition. (hematology.org)
- Blood stage malaria causes systemic inflammation and acute hemolytic anemia in mice [ 20 ], which are events that trigger stress hematopoiesis to generate phagocytic cells involved in parasite clearance and new erythrocytes to cope with anemia [ 21 - 24 ]. (hindawi.com)
- In murine malaria models, stress hematopoiesis associates with egression of HSPC from the BM to spleen, which becomes the major site of erythropoiesis [ 25 , 26 ] and myelopoiesis [ 27 , 28 ]. (hindawi.com)
- However, in humans with certain diseases and in some animals, erythropoiesis also occurs outside the bone marrow, within the spleen or liver. (wikipedia.org)
- RELEVANCE includes 13 partners representing academic research centres, diagnostic labs, blood supply centres, and small industries that combines basic and translational research to improve prognostic, diagnostic and therapeutic approaches on red blood cells production, function, and clearance in healthy humans and patients. (eurobloodnet.eu)
Treatment with erythropoiesis-stimul1
- The p38alpha MAP kinase plays a critical role linking developmental and stress-induced erythropoiesis through regulation of Epo expression. (nih.gov)
- It is not clear whether HIF signaling in other renal cell types also contributes to the regulation of EPO production. (nih.gov)
- When erythropoiesis was inhibited pharmacologically, Hamp1 was no longer suppressed despite profound elevations in serum EPO, indicating that EPO by itself is not directly involved in Hamp1 regulation. (nih.gov)
- We hypothesised that substantial differential regulation of gene expression during erythroid development accounts for these important differences between hiPSC-derived cells and those from adult or cord-blood progenitors. (ox.ac.uk)
- RESULTS: Our high resolution transcriptional view of definitive erythropoiesis captures the regulation of genes relevant to cell-cycle control and confers statistical power to deploy novel bioinformatics methods. (ox.ac.uk)
- HiPSCs show reduced expression of c-KIT and key erythroid transcription factors SOX6, MYB and BCL11A, strong HBZ-induction, and aberrant expression of genes involved in protein degradation, lysosomal clearance and cell-cycle regulation. (ox.ac.uk)
- Our laboratory continues to focus on the molecular pathology and physiology of red cell development, the molecular basis of inherited hemolytic anemias, and the use of the red cell homeostatic system as a model to study gene regulation and growth control in other tissues. (dana-farber.org)
- This may be due to increased immune activation because pro-inflammatory cytokines inhibit erythropoiesis in vitro . (asnjournals.org)
- Finally, we analyze various regulators of erythropoiesis, both in vivo and in vitro. (springer.com)
- Characterization of the erythropoiesis in myelodysplasia by means of ferrokinetic studies, in vitro erythroid colony formation and soluble transferrin receptor. (biomedsearch.com)
- To study the in vivo and in vitro erythropoiesis in more detail erythron transferrin uptake (ETU), soluble transferrin receptor (sTfR) and erythroid in vitro colony formation were performed in 24 patients with RA and five patients with RARS. (biomedsearch.com)
- Within Sanquin a robust human in vitro culture system for the generation of mature MK from hematopoietic stem (CD34 + ) cells has been developed over the past 10 years. (sanquin.nl)
- BACKGROUND: Human-induced pluripotent stem cells (hiPSCs) are a potentially invaluable resource for regenerative medicine, including the in vitro manufacture of blood products. (ox.ac.uk)
- In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos. (nature.com)
- Without it, definitive erythropoiesis does not take place. (wikipedia.org)
- CONCLUSIONS: Together, these data suggest that hiPSC-derived cells may be specified to a primitive erythroid fate, and implies that definitive specification may more accurately reflect adult development. (ox.ac.uk)
- A common precursor for primitive erythropoiesis and definitive haematopoiesis. (nature.com)
- To investigate the role of glial cells as a component of the systemic response to hypoxia, we created astrocyte-specific deletions of the murine genes encoding the hypoxia-inducible transcription factors HIF-1α and HIF-2α and their negative regulator von Hippel-Lindau (VHL) as well as astrocyte-specific deletion of the HIF target gene Vegf. (jci.org)
- Thus, we have demonstrated that the glial component of the CNS is an essential component of hypoxia-induced erythropoiesis. (jci.org)
- Decreases of renal pO2 promote hypoxia-inducible factor 2-mediated (HIF-2-mediated) induction of EPO in peritubular interstitial fibroblast-like cells, which serve as the cellular site of EPO synthesis in the kidney. (nih.gov)
- To address the description of erythropoietic functions, this paper introduces the present understanding of erythropoiesis in vertebrates, focusing on erythropoietic responses to environmental stress, hypoxia, and lowered temperature. (hindawi.com)
- When the mothers were exposed to hypoxia during pregnancy, significantly higher haematocrit- and reticulocyte levels were observed, and there was no difference in erythropoiesis of anephric newborn compared with newborn with intact kidneys. (biologists.org)
- AKBA ), a biopharmaceutical company focused on delivering innovative therapies to patients with kidney disease through the biology of hypoxia-inducible factor ( HIF ), today announced that the Company dosed the first patient in its Phase 2 FORWARD study of vadadustat in dialysis-dependent chronic kidney disease (DD-CKD) patients who are hyporesponsive to erythropoiesis -stimulating agents (ESAs). (wn.com)
- Moreover, it has recently become increasingly clear that various environmental stresses could induce the erythropoiesis via various modulating systems, while all vertebrates live in various environments and habitually adapt to environmental stress. (hindawi.com)
- We demonstrate here that the TNFα/neutral SMase/ceramide pathway inhibits erythropoiesis to induce myelopoiesis via modulation of a hematopoietic TF/miR network and inhibition of late steps of autophagy. (inpst.net)
- 7 Sickle Cell Anaemia. (wiley.com)
- 4.1.1 The Assessment Group identified 23 randomised controlled trials (RCTs) evaluating the effectiveness and safety of erythropoiesis‑stimulating agents (ESAs) for treating cancer treatment‑related anaemia. (nice.org.uk)
- Some of the trials allowed concomitant treatments for anaemia including granulocyte colony‑stimulating factor, iron and red blood cell transfusions. (nice.org.uk)
- Its focus on erythropoiesis represents an attempt to cover a rapidly expanding field, which has gone from elegant studies of erythro- poietin physiology, to molecular biology, to clinical applications and again to physiology. (springer.com)
- Once purified, molecular biology applications have been developed for transcriptome analyses and quantitative analyses in single cells. (grantome.com)
- Research Studies of Erythropoiesis and Iron Biology. (grantome.com)
- Donor-specific information will be correlated with these research studies to identify factors that may assist with the understanding of adult stem cell biology. (clinicaltrials.gov)
- NSG™ mouse model variants are the most highly immunodeficient mice and the models of choice for cancer xenograft modeling, stem cell biology, humanized mice, and infectious disease research. (jax.org)
- BFU-Es express the cell surface antigen, CD34, as do all other early hematopoietic progenitors allowing for its isolation using anti-CD34 antibodies. (upenn.edu)
- Chromatin immunoprecipitation assays in human CD34(+) cells supported a TIF1gamma-dependent recruitment of positive elongation factors to erythroid genes to promote transcription elongation by counteracting Pol II pausing. (nih.gov)
- Adult erythropoiesis is a tightly regulated process which occurs in the bone marrow. (frontiersin.org)
- Distinct gene expression program dynamics during erythropoiesis from human induced pluripotent stem cells compared with adult and cord blood progenitors. (ox.ac.uk)
- Whilst the dynamics of erythroid program elaboration from adult and cord blood progenitors were very similar, the emerging erythroid transcriptome in hiPSCs revealed radically different program elaboration compared to adult and cord blood cells. (ox.ac.uk)
- Finally, miR 221 and 222 gene transfer impairs proliferation of the kit+ TF-1 erythroleukemic cell line. (pnas.org)
- 7 days were allowed for proliferation of these cells, and then the granulocytic or erythrocytic progeny was measured. (rupress.org)
- HiPSC-derived red blood cells are an attractive therapeutic option in hematology, yet exhibit unexplained proliferation and enucleation defects that presently preclude such applications. (ox.ac.uk)
- Reactive oxygen species (ROS) in cells play crucial roles in gene transcription, proliferation/survival of cells, and cellular defenses. (haematologica.org)
- Knowing that BALB/c mice with acute Plasmodium chabaudi adami malaria have profound alterations in bone remodelling cells, we evaluated the extent to which osteoclasts influence their hematopoietic response to infection. (hindawi.com)
- Here, we used a genetic approach in mice to investigate the role of renal epithelial HIF in erythropoiesis. (nih.gov)
- The role of the kidney in foetal erythropoiesis was studied in newborn SD mice on the day of birth. (biologists.org)
- Taken together, we provide in vivo evidence that Hamp1 suppression by the HIF pathway occurs indirectly through stimulation of EPO-induced erythropoiesis. (nih.gov)
- Using male Wistar rats, we unmask a previously unrecognized regulatory pathway of erythropoiesis involving suppressor control by the NO metabolite and ubiquitous dietary component nitrate. (sigmaaldrich.com)
- Autophagy plays an essential role during erythropoiesis and our results demonstrate that the TNFα/neutral SMase/ceramide pathway inhibits autophagy in EpoCD34/HSPCs. (inpst.net)
- Multipotent hematopoietic cells gain access to the T cell developmental pathway and then confirm that choice of fate by "burning their bridges" to other pathways. (jimmunol.org)
- Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. (uniprot.org)
- Genetically engineered bone marrow-derived mesenchymal stem cells co-expressing IFN-γ and IL-10 inhibit hepatocellular carcinoma by modulating MAPK pathway. (annals.org)
- Red blood cells (RBCs) mediate oxygen transport throughout the body, a function that is essential for life. (europa.eu)
- There is an increased tendency for reactive oxygen species accumulation in β1 Δ/Δ erythroid cells with decreased anti-oxidant defenses at homeostasis which are exaggerated after stress. (haematologica.org)
- Red Blood Cells (RBC's) also called erythrocytes, are oxygen carrying cells. (nursingcrib.com)
- Red blood cells are vital to your health and well-being, carrying oxygen to cells throughout your body and carbon dioxide away from them so that it can be expelled. (livestrong.com)
- During their development and mature life, red blood cells (RBC) interact numerous times with macrophages, first during their development in the bone marrow, later in the blood stream with macrophages in the liver and spleen. (frontiersin.org)
- Furthermore, expansion of erythroid cells in spleen post-stress is dependent on α5β1, likely through mechanisms activating focal adhesion kinase complexes that are distinct from α4β1-mediated responses. (haematologica.org)
- Macrophages tightly control the production and clearance of red blood cells (RBC). (frontiersin.org)
- New evidence suggests that not only under homeostasis but also under stress conditions, macrophages play an important role in promoting erythropoiesis. (frontiersin.org)
- In addition, we will discuss the interactions between these two cell types during transfer of immune complexes and pathogens from RBC to macrophages. (frontiersin.org)
Pure red cel2
- The most commonly used immunoassay methods in the industry for detection of binding antibodies (BAbs) are the enzyme-linked immunosorbent assay (ELISA), radioimmunoprecipitation assay (RIPA), electrochemiluminescence (ECL) assay, and surface plasmon resonance immunoassay (SPRIA), all of which have been demonstrated to detect the pathogenic antibodies in patients who develop antibody-mediated pure red cell aplasia (amPRCA) ( 3 ). (asm.org)
- A serious adverse effect of long-term administration of ESA is pure red cell aplasia. (springer.com)
- Cre activity was only detected in renal epithelial cells (arrows), whereas glomeruli were not stained (asterisks). (nih.gov)
- Erythropoiesis of the newborn with renal agenesis was not different from that of animals with intact kidneys. (biologists.org)
- By 2 to 3 months of age the urine becomes green due to hemosiderin and ferritin laden renal tubular cells and the urine later becomes red. (jax.org)