Cells erythropoiesis. Medical search

Congenital dyserythropoietic anemia (CDA) is a rare group of red blood cell disorders characterized by ineffective erythropoiesis and increased iron absorption. (ru.nl)
To determine whether growth differentation factor 15 (GDF15) hyper-expression is associated with the ineffective erythropoiesis and iron-loading complications of CDA type I (CDA I), GDF15 levels and other markers of erythropoiesis and iron overload were studied in blood from 17 CDA I patients. (ru.nl)

Chemical and genetic inhibition of NLK increases erythroid expansion in mouse and human progenitors, including bone marrow cells from DBA patients. (lu.se)

Association of red blood cell distribution width (RDW) with mortality in the Third National Health and Nutrition Examination Survey (NHANES III). (jamanetwork.com)
Tonelli MSacks FArnold MMoye LDavis BPfeffer MCholesterol and Recurrent Events (CARE) Trial Investigators, Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. (jamanetwork.com)

Does Erythropoietin Regulate TRPC Channels in Red Blood Cells? (europa.eu)
A key adaptation to environmental hypoxia is an increase in erythropoiesis, driven by the hormone erythropoietin (EPO) through what is traditionally thought to be primarily a renal response. (jci.org)
Using FACScan flow cytometry, the proportion of PMA/ionomycin-stimulated T cells expressing cytokines ex vivo was compared in 18 poor responders to erythropoietin, 14 good responders to erythropoietin, and 14 normal controls. (asnjournals.org)
Anemia is a major complication of end-stage renal disease (ESRD), occurring primarily as a result of reduced erythropoietin production from the peritubular cells of the kidney ( 1 ). (asnjournals.org)
Patients treated with erythropoietin-based erythropoiesis-stimulating agents (ESAs) can develop a rare but life-threatening condition called antibody-mediated pure red cell aplasia (amPRCA). (asm.org)
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. (nih.gov)
Whereas some p38alpha(-/-) embryos die between embryonic days 11.5 and 12.5, those that develop past this stage have normal morphology but are anemic owing to failed definitive erythropoiesis, caused by diminished erythropoietin (Epo) gene expression. (nih.gov)
Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin. (nih.gov)
The adult kidney plays a central role in erythropoiesis and is the main source of erythropoietin (EPO), an oxygen-sensitive glycoprotein that is essential for red blood cell production. (nih.gov)
Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. (springer.com)
Differentiation and erythropoietin receptor gene expression in human erythroid progenitor cells. (springer.com)
n red blood cell production that occurs in bone marrow and involves maturation of nucleated precursors into erythrocytes regulated by the hormone erythropoietin produced in the kidneys. (thefreedictionary.com)
Iron demand in bone marrow increases when erythropoiesis is stimulated by hypoxia via increased erythropoietin (EPO) synthesis in kidney and liver. (nih.gov)
A feedback loop involving erythropoietin helps regulate the process of erythropoiesis so that, in non-disease states, the production of red blood cells is equal to the destruction of red blood cells and the red blood cell number is sufficient to sustain adequate tissue oxygen levels but not so high as to cause sludging, thrombosis, or stroke. (wikipedia.org)
Garlic accelerates red blood cell turnover and splenic erythropoietic gene expression in mice: evidence for erythropoietin-independent erythropoiesis. (duke.edu)
Thus, garlic consumption not only causes increased energy demand from the faster RBC turnover but also increases the production of CO, which in turn stimulates splenic erythropoiesis by an erythropoietin-independent mechanism, thus completing the sequence of feedback regulation for RBC metabolism. (duke.edu)
Erythropoietin is a hormone produced in the kidney, which increases the production of red blood cells. (cochrane.org)
Experiments were performed to test the hypothesis that rats could be made permanently anemic by repeated mixed gamma-neutron irradiations, and that once the maintenance of normal circulatory red cell concentration was lost, the administration of exogenous erythropoietin could not restore the production of red cells to normal levels. (dtic.mil)
This study indicates that murine foetal erythropoiesis is regulated by erythropoietin in the same way as later in life. (biologists.org)
Exogenous erythropoietin, recombinant human erythropoietin (rhEPO) is produced by recombinant DNA technology in cell culture and are collectively called erythropoiesis-stimulating agents (ESA): two examples are epoetin alfa and epoetin beta. (wikipedia.org)
Erythropoietin is an essential hormone for red blood cell production. (wikipedia.org)
Under hypoxic conditions, the kidney will produce and secrete erythropoietin to increase the production of red blood cells by targeting CFU-E, proerythroblast and basophilic erythroblast subsets in the differentiation. (wikipedia.org)
Erythropoietin has its primary effect on red blood cell progenitors and precursors (which are found in the bone marrow in humans) by promoting their survival through protecting these cells from apoptosis, or cell death. (wikipedia.org)
The burst-forming unit-erythroid (BFU-E) cells start erythropoietin receptor expression and are sensitive to erythropoietin. (wikipedia.org)
Precursors of red cells, the proerythroblasts and basophilic erythroblasts also express erythropoietin receptor and are therefore affected by it. (wikipedia.org)
Erythropoietin was reported to have a range of actions beyond stimulation of erythropoiesis including vasoconstriction-dependent hypertension, stimulating angiogenesis, and promoting cell survival via activation of EPO receptors resulting in anti-apoptotic effects on ischemic tissues. (wikipedia.org)
EPO binds to the erythropoietin receptor on the red cell progenitor surface and activates a JAK2 signaling cascade. (wikipedia.org)
High level erythropoietin receptor expression is localized to erythroid progenitor cells. (wikipedia.org)
In the bloodstream, red cells themselves do not express erythropoietin receptor, so cannot respond to EPO. (wikipedia.org)
Treatment with erythropoiesis-stimulating agents (ESAs) has been used as a pharmacologic strategy when the blunted response of endogenous erythropoietin has been reported in critically-ill people. (cochrane.org)
He later conducted important research on the formation of blood cells, studying the regulatory hormone erythropoietin, and the process of hemopoiesis, the formation of blood cells. (uchicago.edu)
QGR significantly increased the cell viability of BMNCs even in hypoxic condition, and mRNA expressions of stem cell factor, granulocyte macrophage-colony stimulating factor and erythropoietin from bone marrow stromal cells. (pharmalicensing.com)
In mammals, hypoxia-triggered erythropoietin release increases red blood cell mass to meet tissue oxygen demands. (sigmaaldrich.com)
This is possible because erythropoietin is present in the central nervous system, because erythropoiesis-secreting tissues are widely distributed in humans, and because erythropoiesis receptors are expressed in human neurons, glia cells, astrocytes, and cerebral endothelial cells, they wrote. (medpagetoday.com)
The JAK2 V617F point mutation makes the normal hematopoietic progenitor cells hypersensitive to thrombopoietin, erythropoietin, and myeloid progenitor cells, leading to trilinear hematopoietic myeloproliferation. (qxmd.com)
During anemia erythropoiesis is bolstered by several factors including KIT ligand, oncostatin-M, glucocorticoids, and erythropoietin. (semanticscholar.org)
For many years bone marrow anoxia was thought to stimulate erythropoiesis, but there is growing acceptance of the belief that a hormone, erythropoietin, provides the marrow with the immediate stimulus for blood production. (annals.org)
ESAs work like the human protein erythropoietin, which stimulates bone marrow to make red blood cells. (ascopost.com)

Cell Death and Differentiation, issue 24/9, 2017. (europa.eu)
Functional studies show that treatment of CD34+ progenitors with miR 221 and 222, via oligonucleotide transfection or lentiviral vector infection, causes impaired proliferation and accelerated differentiation of E cells, coupled with down-modulation of kit protein: this phenomenon, observed in E culture releasing endogenous kit ligand, is magnified in E culture supplemented with kit ligand. (pnas.org)
We have performed genomewide expression profiling of miRs ( 11 ) in the human hematopoietic lineages, as evaluated in unilineage differentiation/maturation culture of cord blood (CB) CD34+ hematopoietic progenitor cells (HPCs). (pnas.org)
Hematopoietic stem cell differentiation involves the silencing of self-renewal genes and induction of a specific transcriptional program. (igsb.org)
Using a replicative primary human hematopoietic stem/progenitor cell differentiation system, we demonstrate dynamic changes of 5-hydroxymethylcytosine (5-hmC) during stem cell commitment and differentiation to the erythroid lineage. (igsb.org)
The functional importance of 5-hmC was demonstrated by impaired erythroid differentiation, with augmentation of myeloid potential, and disrupted 5-hmC patterning in leukemia patient-derived CD34+ stem/early progenitor cells with TET methylcytosine dioxygenase 2 (TET2) mutations. (igsb.org)
Thus, chemical conjugation and affinity purification of 5-hmC-enriched sequences followed by sequencing serve as resources for deciphering functional implications for gene expression during stem cell commitment and differentiation along a particular lineage. (igsb.org)
Cell differentiation along the erythroid lineage occurs over a two week span in humans. (upenn.edu)
Terminal erythroid differentiation is tightly coordinated with cell cycle exit, which is regulated by cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors (CDKI), yet their roles in erythropoiesis remain to be fully defined. (bloodjournal.org)
We show here that p19 INK4d , a member of CDKI family, is abundantly expressed in erythroblasts and that p19 INK4d knockdown delayed erythroid differentiation, inhibited cell growth, led to increased apoptosis and generation of abnormally nucleated late stage erythroblasts. (bloodjournal.org)
A major focus of the laboratory involves studies of erythropoiesis in real-time as stem cells undergo erythroid commitment and differentiation. (grantome.com)
Undifferentiated CD34+ cells were transduced with the Lentivirus and SF3B1 gene knockdown was induced by doxycycline in different differentiation stages across human erythropoiesis. (ehaweb.org)
This hormone stimulates proliferation and differentiation of red cell precursors, which activates increased erythropoiesis in the hemopoietic tissues, ultimately producing red blood cells (erythrocytes). (wikipedia.org)
In stem and progenitor cells, Bach2 and Bach1 were found to promote lymphoid cell differentiation by restricting the expression of myeloid transcription factors as well as their target genes important for myeloid cell differentiation. (nii.ac.jp)
The RTN will generate a comprehensive molecular description of mechanisms governing erythropoiesis, from specification of hematopoietic stem cells in embryogenesis to terminal differentiation and post-mitotic maturation of red blood cels. (europa.eu)
Vitamin A is involved in regulating the growth and specialization ( differentiation ) of virtually all cells in the human body. (oregonstate.edu)
This results in differentiation, survival and proliferation of the erythroid cell. (wikipedia.org)
Platelet assembly and release are the final events of a multi-step process involving commitment, proliferation and differentiation of hematopoietic stem cells (HSC) to megakaryocytes (MK). (sanquin.nl)
Recent advances in the area of stem cell research suggest that redirected differentiation of stem cells may prove useful for the treatment of a variety of diseases including diabetes and other systemic diseases. (clinicaltrials.gov)
In the hematopoietic system, recent studies have also demonstrated the ability of adult erythroid stem cells to undergo differentiation toward a fetal-like phenotype. (clinicaltrials.gov)
In addition, it is clear that the stem cells from separate donors do not possess identical properties of growth and differentiation. (clinicaltrials.gov)
The cells will then be studied in-depth for a better understanding of their biological properties, growth and differentiation. (clinicaltrials.gov)
The molecular and cellular biological pathways involved in erythroid cell differentiation. (nih.gov)
This includes not only adult or definitive erythropoiesis (differentiation), but also ontological or primitive erythropoiesis (development). (nih.gov)
Our study establishes a mechanism for regulating tissue cell fate and differentiation through transcription elongation. (nih.gov)
TNFα is also a potent activator of the sphingomyelinase (SMase)/ceramide pathway leading to ceramide synthesis and regulating cell differentiation, proliferation, apoptosis, senescence, and autophagy. (inpst.net)
Analysis of cell morphology and colony formation demonstrated that erythropoiesis impairment was concomitant with a granulomonocytic differentiation in TNFα- and ceramide-treated EpoCD34/HSPCs. (inpst.net)
Inhibition of erythropoiesis and induction of granulomonocytic differentiation were correlated to modulation of hematopoietic transcription factors (TFs) GATA-1, GATA-2, and PU.1. (inpst.net)
We have therefore identified, for the first time, distinct gene expression dynamics during erythroblast differentiation from hiPSCs which may cause reduced proliferation and enucleation of hiPSC-derived erythroid cells. (ox.ac.uk)
Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. (uniprot.org)
Our group has identified at least three target sequence areas and one putative splicing factor involved in tissue-specific regulation of red cell isoforms during erythroid differentiation. (dana-farber.org)
Moreover, as cells approach the state of terminal differentiation, there is a clear shift from the intranuclear localization of protein 4.1R to peripheral localization. (dana-farber.org)
Current studies are pursuing the hypothesis that this complex shift in localization and association is indicative of a role for protein 4.1R in signaling terminal differentiation and initiating shutdown of cell proliferation and division. (dana-farber.org)
These stem cells are dependent on vitamin A for differentiation into red blood cells. (livestrong.com)

Globally, our results indicate that although osteoclast-dependent HSC mobilization from bone marrow to spleen is triggered in murine blood stage malaria, this activity is not essential for stress erythropoiesis. (hindawi.com)
Stress Erythropoiesis. (nih.gov)
Epo, stem cell factor, GATA-1, are also required for stress erythropoiesis, it is generally believed that the latter is controlled by additional and distinct molecular networks. (haematologica.org)

In erythropoietic (E) culture of cord blood CD34+ progenitor cells, the level of miR 221 and 222 is gradually and sharply down-modulated. (pnas.org)
In accord with this, erythroid progenitor cells and reticulocytes were substantially reduced in number in mice lacking HIF function in astrocytes following hypoxic stress. (jci.org)
The activity of osteoclasts seems required for the mobilization of hematopoietic stem and progenitor cells (HSPC) from the bone marrow to the periphery. (hindawi.com)
Recent studies involve bone resorbing osteoclasts in the homeostasis and mobilization of HSC and hematopoietic progenitor cells (HSPC) in conditions of stress, although this function remains controversial [ 8 - 11 ]. (hindawi.com)
Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis. (igsb.org)
Gelsolin is expressed in early erythroid progenitor cells and negatively regulated during erythropoiesis. (rupress.org)
From quantitations of its steady-state molar ratio to actin, gelsolin is abundant in early progenitor cells as revealed from avian erythroblastosis virus- and S13 virus-transformed cells which are arrested at the colony forming unit erythroid (CFU-e) stage of erythroid development. (rupress.org)
This down regulation is independent from that of actin, which is considerably less, and is observed also when S13-transformed erythroid progenitor cells are induced to differentiate under conditions where the actin content of these cells does not change. (rupress.org)
The following stages of development all occur within the bone marrow: A Hemocytoblast, a multipotent hematopoietic stem cell, becomes a common myeloid progenitor or a multipotent stem cell, and then a unipotent stem cell, then a pronormoblast, also commonly called an proerythroblast or a rubriblast. (wikipedia.org)
We show for the first time that the analyzed conformational mutations lead to higher cell viability in human hematopoietic stem progenitor cells. (oncotarget.com)
Both hematopoietic cells and cells that form the hematopoietic stem and progenitor cell niche have been identified as targets of GvHD. (wiley.com)
We previously developed a lentiviral system that allows us to over-express and knock-down MEIS1 in human hematopoietic stem and progenitor cells. (sanquin.nl)
The harvested product will be purified for the primitive hematopoietic progenitor cells and viably preserved in multiple aliquots. (clinicaltrials.gov)
BMNCs including hematopoietic stem cells (HSCs), early progenitor cells (EPCs), stromal cells and other precursor cells were isolated from femurs and tibias of 8 to 12-week-old male C57BL/6 mice. (pharmalicensing.com)
Talving and colleagues explained that in TBI, ESAs may mediate anti-inflammatory and anti-apoptotic responses, and also may enhance angiogenic properties by recruiting endothelial progenitor cells in brain tissue. (medpagetoday.com)
Here we evaluated the implication of the TNFα/SMase/ceramide pathway on inhibition of erythropoiesis in human CD34+ hematopoietic stem/progenitor cells (CD34/HSPCs) from healthy donors. (inpst.net)
Orsini M, Chateauvieux S, Rhim J, Gaigneaux A, Cheillan D, Christov C, Dicato M, Morceau F, Diederich M. Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells . (inpst.net)
DYRK3 is restricted to erythroid progenitor cells and testes. (semanticscholar.org)
It has been proposed that during embryonic development haematopoietic cells arise from a mesodermal progenitor with both endothelial and haematopoietic potential called the haemangioblast 1 , 2 . (nature.com)
17 , 18 , 20 Since the ability of these special progenitor cells to respond to stress depends on cues from the microenvironment (ME) of the spleen rather than the bone marrow (BM), distinct erythroid cell/ME interactions are apparently at play in the former but not the latter environment under stress. (haematologica.org)
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells. (jove.com)

Furthermore, terminal erythropoiesis has been reported to take place in a specialized microenvironment called the erythroblastic island. (frontiersin.org)
Protein 4.1R Exon 16 3' Splice Site Activation Requires Coordination among TIA1, Pcbp1, and RBM39 during Terminal Erythropoiesis. (dana-farber.org)

These observations demonstrate that different patterns of defects can be observed in the erythropoiesis of RA and RARS patients whereby normal to increased ETU levels and the presence of cytogenetic abnormalities differentiate between cases of RA with ineffective erythropoiesis associated with regular transfusions and cases who are relatively transfusion independent. (biomedsearch.com)
This condition is characterized by ineffective erythropoeisis , bone-marrow expansion, and rapid destruction of erythrocytes. (thefreedictionary.com)
We found that, at homeostasis, β1-deficient mice have a modest uncompensated anemia with ineffective erythropoiesis and decreased red blood cell survival. (haematologica.org)
Which lab results are characteristic of ineffective erythropoiesis (ELB production) in unconjugated hyperbilirubinemia? (medscape.com)
Ineffective erythropoiesis (ELB production) is characterized by a marked increase in fecal urobilinogen excretion and a normal or near-normal red blood cell lifespan. (medscape.com)
While the thalassemia syndromes are heterogeneous, including homozygous or compound heterozygous β-globin defects, the pathophysiology is primarily related to ineffective erythropoiesis and systemic iron overload with tissue iron deposition. (hematology.org)

Blood stage malaria causes systemic inflammation and acute hemolytic anemia in mice [ 20 ], which are events that trigger stress hematopoiesis to generate phagocytic cells involved in parasite clearance and new erythrocytes to cope with anemia [ 21 - 24 ]. (hindawi.com)
In murine malaria models, stress hematopoiesis associates with egression of HSPC from the BM to spleen, which becomes the major site of erythropoiesis [ 25 , 26 ] and myelopoiesis [ 27 , 28 ]. (hindawi.com)

However, in humans with certain diseases and in some animals, erythropoiesis also occurs outside the bone marrow, within the spleen or liver. (wikipedia.org)
RELEVANCE includes 13 partners representing academic research centres, diagnostic labs, blood supply centres, and small industries that combines basic and translational research to improve prognostic, diagnostic and therapeutic approaches on red blood cells production, function, and clearance in healthy humans and patients. (eurobloodnet.eu)

Despite treatment with erythropoiesis-stimulating agents (ESAs), some patients experienced ESA hyporesponsiveness. (biomedsearch.com)

The p38alpha MAP kinase plays a critical role linking developmental and stress-induced erythropoiesis through regulation of Epo expression. (nih.gov)
It is not clear whether HIF signaling in other renal cell types also contributes to the regulation of EPO production. (nih.gov)
When erythropoiesis was inhibited pharmacologically, Hamp1 was no longer suppressed despite profound elevations in serum EPO, indicating that EPO by itself is not directly involved in Hamp1 regulation. (nih.gov)
We hypothesised that substantial differential regulation of gene expression during erythroid development accounts for these important differences between hiPSC-derived cells and those from adult or cord-blood progenitors. (ox.ac.uk)
RESULTS: Our high resolution transcriptional view of definitive erythropoiesis captures the regulation of genes relevant to cell-cycle control and confers statistical power to deploy novel bioinformatics methods. (ox.ac.uk)
HiPSCs show reduced expression of c-KIT and key erythroid transcription factors SOX6, MYB and BCL11A, strong HBZ-induction, and aberrant expression of genes involved in protein degradation, lysosomal clearance and cell-cycle regulation. (ox.ac.uk)
Our laboratory continues to focus on the molecular pathology and physiology of red cell development, the molecular basis of inherited hemolytic anemias, and the use of the red cell homeostatic system as a model to study gene regulation and growth control in other tissues. (dana-farber.org)

This may be due to increased immune activation because pro-inflammatory cytokines inhibit erythropoiesis in vitro . (asnjournals.org)
Finally, we analyze various regulators of erythropoiesis, both in vivo and in vitro. (springer.com)
Characterization of the erythropoiesis in myelodysplasia by means of ferrokinetic studies, in vitro erythroid colony formation and soluble transferrin receptor. (biomedsearch.com)
To study the in vivo and in vitro erythropoiesis in more detail erythron transferrin uptake (ETU), soluble transferrin receptor (sTfR) and erythroid in vitro colony formation were performed in 24 patients with RA and five patients with RARS. (biomedsearch.com)
Within Sanquin a robust human in vitro culture system for the generation of mature MK from hematopoietic stem (CD34 + ) cells has been developed over the past 10 years. (sanquin.nl)
BACKGROUND: Human-induced pluripotent stem cells (hiPSCs) are a potentially invaluable resource for regenerative medicine, including the in vitro manufacture of blood products. (ox.ac.uk)
In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos. (nature.com)

Without it, definitive erythropoiesis does not take place. (wikipedia.org)
CONCLUSIONS: Together, these data suggest that hiPSC-derived cells may be specified to a primitive erythroid fate, and implies that definitive specification may more accurately reflect adult development. (ox.ac.uk)
A common precursor for primitive erythropoiesis and definitive haematopoiesis. (nature.com)

In this study, we elucidated a lncRNA (UCA1)-mediated mechanism that regulates heme metabolism in human erythroid cells. (nature.com)
Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. (uniprot.org)

Regular daily fluctuations in spontaneous physical activity and in the mitotic indices of marrow and splenic erythroid elements and pinna cells, were observed. (elsevier.com)
The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis. (semanticscholar.org)

To investigate the role of glial cells as a component of the systemic response to hypoxia, we created astrocyte-specific deletions of the murine genes encoding the hypoxia-inducible transcription factors HIF-1α and HIF-2α and their negative regulator von Hippel-Lindau (VHL) as well as astrocyte-specific deletion of the HIF target gene Vegf. (jci.org)
Thus, we have demonstrated that the glial component of the CNS is an essential component of hypoxia-induced erythropoiesis. (jci.org)
Decreases of renal pO2 promote hypoxia-inducible factor 2-mediated (HIF-2-mediated) induction of EPO in peritubular interstitial fibroblast-like cells, which serve as the cellular site of EPO synthesis in the kidney. (nih.gov)
To address the description of erythropoietic functions, this paper introduces the present understanding of erythropoiesis in vertebrates, focusing on erythropoietic responses to environmental stress, hypoxia, and lowered temperature. (hindawi.com)
When the mothers were exposed to hypoxia during pregnancy, significantly higher haematocrit- and reticulocyte levels were observed, and there was no difference in erythropoiesis of anephric newborn compared with newborn with intact kidneys. (biologists.org)
AKBA ), a biopharmaceutical company focused on delivering innovative therapies to patients with kidney disease through the biology of hypoxia-inducible factor ( HIF ), today announced that the Company dosed the first patient in its Phase 2 FORWARD study of vadadustat in dialysis-dependent chronic kidney disease (DD-CKD) patients who are hyporesponsive to erythropoiesis -stimulating agents (ESAs). (wn.com)

Moreover, it has recently become increasingly clear that various environmental stresses could induce the erythropoiesis via various modulating systems, while all vertebrates live in various environments and habitually adapt to environmental stress. (hindawi.com)
We demonstrate here that the TNFα/neutral SMase/ceramide pathway inhibits erythropoiesis to induce myelopoiesis via modulation of a hematopoietic TF/miR network and inhibition of late steps of autophagy. (inpst.net)

7 Sickle Cell Anaemia. (wiley.com)
4.1.1 The Assessment Group identified 23 randomised controlled trials (RCTs) evaluating the effectiveness and safety of erythropoiesis‑stimulating agents (ESAs) for treating cancer treatment‑related anaemia. (nice.org.uk)
Some of the trials allowed concomitant treatments for anaemia including granulocyte colony‑stimulating factor, iron and red blood cell transfusions. (nice.org.uk)

Dr. Richard Levere was a pioneer in many studies of heme metabolism and of erythropoiesis. (springer.com)
Adenine nucleotide translocases (ANTs) transport ADP and ATP through mitochondrial inner membrane, thus playing an essential role for energy metabolism of eukaryotic cells. (sigmaaldrich.com)

Can iron overload in patients with lower-risk myelodysplastic syndromes be reduced using erythropoiesis-stimulating agents? (aamds.org)
Does addition of erythropoiesis stimulating agents improve the outcome of higher-risk myelodysplastic syndromes treated with azacitidine? (aamds.org)

Its focus on erythropoiesis represents an attempt to cover a rapidly expanding field, which has gone from elegant studies of erythro- poietin physiology, to molecular biology, to clinical applications and again to physiology. (springer.com)
Once purified, molecular biology applications have been developed for transcriptome analyses and quantitative analyses in single cells. (grantome.com)
Research Studies of Erythropoiesis and Iron Biology. (grantome.com)
Donor-specific information will be correlated with these research studies to identify factors that may assist with the understanding of adult stem cell biology. (clinicaltrials.gov)
NSG™ mouse model variants are the most highly immunodeficient mice and the models of choice for cancer xenograft modeling, stem cell biology, humanized mice, and infectious disease research. (jax.org)

BFU-Es express the cell surface antigen, CD34, as do all other early hematopoietic progenitors allowing for its isolation using anti-CD34 antibodies. (upenn.edu)
Chromatin immunoprecipitation assays in human CD34(+) cells supported a TIF1gamma-dependent recruitment of positive elongation factors to erythroid genes to promote transcription elongation by counteracting Pol II pausing. (nih.gov)

Adult erythropoiesis is a tightly regulated process which occurs in the bone marrow. (frontiersin.org)
Distinct gene expression program dynamics during erythropoiesis from human induced pluripotent stem cells compared with adult and cord blood progenitors. (ox.ac.uk)
Whilst the dynamics of erythroid program elaboration from adult and cord blood progenitors were very similar, the emerging erythroid transcriptome in hiPSCs revealed radically different program elaboration compared to adult and cord blood cells. (ox.ac.uk)

Finally, miR 221 and 222 gene transfer impairs proliferation of the kit+ TF-1 erythroleukemic cell line. (pnas.org)
7 days were allowed for proliferation of these cells, and then the granulocytic or erythrocytic progeny was measured. (rupress.org)
HiPSC-derived red blood cells are an attractive therapeutic option in hematology, yet exhibit unexplained proliferation and enucleation defects that presently preclude such applications. (ox.ac.uk)
Reactive oxygen species (ROS) in cells play crucial roles in gene transcription, proliferation/survival of cells, and cellular defenses. (haematologica.org)

Giving erythropoiesis-stimulating agents after traumatic brain injury may improve survival without increasing comorbidities, researchers found. (medpagetoday.com)

19. A method according to claim 1, in which apoptosis of the animal cell in the cell culture medium is reduced to enhance cell viability. (freepatentsonline.com)

Knowing that BALB/c mice with acute Plasmodium chabaudi adami malaria have profound alterations in bone remodelling cells, we evaluated the extent to which osteoclasts influence their hematopoietic response to infection. (hindawi.com)
Here, we used a genetic approach in mice to investigate the role of renal epithelial HIF in erythropoiesis. (nih.gov)
The role of the kidney in foetal erythropoiesis was studied in newborn SD mice on the day of birth. (biologists.org)

J Cell Biol (1987) 105 (3): 1425-1433. (rupress.org)
Int J Biochem Cell Biol. (medlineplus.gov)
Mol Cell Biol. (dana-farber.org)

Taken together, we provide in vivo evidence that Hamp1 suppression by the HIF pathway occurs indirectly through stimulation of EPO-induced erythropoiesis. (nih.gov)
Using male Wistar rats, we unmask a previously unrecognized regulatory pathway of erythropoiesis involving suppressor control by the NO metabolite and ubiquitous dietary component nitrate. (sigmaaldrich.com)
Autophagy plays an essential role during erythropoiesis and our results demonstrate that the TNFα/neutral SMase/ceramide pathway inhibits autophagy in EpoCD34/HSPCs. (inpst.net)
Multipotent hematopoietic cells gain access to the T cell developmental pathway and then confirm that choice of fate by "burning their bridges" to other pathways. (jimmunol.org)
Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. (uniprot.org)
Genetically engineered bone marrow-derived mesenchymal stem cells co-expressing IFN-γ and IL-10 inhibit hepatocellular carcinoma by modulating MAPK pathway. (annals.org)

Red blood cells (RBCs) mediate oxygen transport throughout the body, a function that is essential for life. (europa.eu)
There is an increased tendency for reactive oxygen species accumulation in β1 Δ/Δ erythroid cells with decreased anti-oxidant defenses at homeostasis which are exaggerated after stress. (haematologica.org)
Red Blood Cells (RBC's) also called erythrocytes, are oxygen carrying cells. (nursingcrib.com)
Red blood cells are vital to your health and well-being, carrying oxygen to cells throughout your body and carbon dioxide away from them so that it can be expelled. (livestrong.com)

RBCs are continuously produced via a process called erythropoiesis. (europa.eu)
Anemias (insufficient numbers of functional RBCs), caused by failure of erythropoiesis, are a major cause of disease in the EC. (europa.eu)
What is the mother cell of RBCs? (studystack.com)

Moreover, rapamycin prevented the inhibitory effect of TNFα and ceramides on erythropoiesis while inhibiting induction of myelopoiesis. (inpst.net)

Quiescent hematopoietic stem cells (HSCs) reside in the bone marrow (BM) near the endosteum, in specific microenvironments called endosteal niches [ 1 - 3 ]. (hindawi.com)

During their development and mature life, red blood cells (RBC) interact numerous times with macrophages, first during their development in the bone marrow, later in the blood stream with macrophages in the liver and spleen. (frontiersin.org)
Furthermore, expansion of erythroid cells in spleen post-stress is dependent on α5β1, likely through mechanisms activating focal adhesion kinase complexes that are distinct from α4β1-mediated responses. (haematologica.org)

Macrophages tightly control the production and clearance of red blood cells (RBC). (frontiersin.org)
New evidence suggests that not only under homeostasis but also under stress conditions, macrophages play an important role in promoting erythropoiesis. (frontiersin.org)
In addition, we will discuss the interactions between these two cell types during transfer of immune complexes and pathogens from RBC to macrophages. (frontiersin.org)

The most commonly used immunoassay methods in the industry for detection of binding antibodies (BAbs) are the enzyme-linked immunosorbent assay (ELISA), radioimmunoprecipitation assay (RIPA), electrochemiluminescence (ECL) assay, and surface plasmon resonance immunoassay (SPRIA), all of which have been demonstrated to detect the pathogenic antibodies in patients who develop antibody-mediated pure red cell aplasia (amPRCA) ( 3 ). (asm.org)
A serious adverse effect of long-term administration of ESA is pure red cell aplasia. (springer.com)

Suppresses fetal liver erythropoiesis. (uniprot.org)

Cre activity was only detected in renal epithelial cells (arrows), whereas glomeruli were not stained (asterisks). (nih.gov)
Erythropoiesis of the newborn with renal agenesis was not different from that of animals with intact kidneys. (biologists.org)
By 2 to 3 months of age the urine becomes green due to hemosiderin and ferritin laden renal tubular cells and the urine later becomes red. (jax.org)

Essential for the maturation of red blood cells are Vitamin B12 (cobalamin) and Vitamin B9 (Folic acid). (wikipedia.org)

Anatomy19

Organisms3

Diseases23

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes17

Anthropology, Education, Sociology and Social Phenomena1

Erythropoietin

Erythropoietin in neuroprotection

TAL1

Darbepoetin alfa

Mir-451 microRNA

CBFA2T3

SOCS3

Mir-22

Franz Ernst Christian Neumann

Mir-154 microRNA precursor family

Mir-185 microRNA precursor family

FLVCR1

Mir-32 microRNA precursor family

HOXB6

KLF2

SBDS

Mir-24 microRNA precursor family

Latent iron deficiency

Transferrin

Vascular endothelial growth factor

Myeloblast

DNA damage-inducible transcript 3

FSTL3

KLF1

MiR-155

Mir-223

Methoxy polyethylene glycol-epoetin beta

KDM5A

Eisenmenger's syndrome

LIG1

ଜଣ୍ଡିସ୍ - ଉଇକିପିଡ଼ିଆ

Fibrinolysis

Innate immune system

Eritropoetin - Wikipédia

Ephrin A4

Red blood cell

Folate

මානව කායිකවේදය - විකිපීඩියා, නිදහස් විශ්වකෝෂය

Jaundice

Blood cell

13-Hydroxyoctadecadienoic acid

위키백과:미번역 문서/의학 - 위키백과, 우리 모두의 백과사전

B vitamins

Sakit na sickle-cell, ang malayang ensiklopedya

Harold M. Weintraub

Iron deficiency

WHO Model List of Essential Medicines

Kidney

GATA1

Anemia of chronic disease

Obesity hypoventilation syndrome

Thrombosis

Endocrine gland

Regeneration (biology)

Cell nucleus

Epoetin alfa

Endocrine system

에리트로포이에틴 - 위키백과, 우리 모두의 백과사전

Androstanolone

Congenital dyserythropoietic anaemia: response to splenectomy and quantitation of ineffective erythropoiesis. | Journal of...

Regulation of red cell life-span, erythropoiesis, survival, senescence and clearance | Projects | H2020 | CORDIS | European...

MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation | PNAS

JCI - The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice

Osteoclasts Are Required for Hematopoietic Stem and Progenitor Cell Mobilization but Not for Stress Erythropoiesis in...

8/3- Stem Cell Hematopoiesis, Erythropoiesis & Marrow Failure Flashcards by Kathryn Kudlaty | Brainscape

Increased Expression of Erythropoiesis Inhibiting Cytokines (IFN-γ, TNF-α, IL-10, and IL-13) by T Cells in Patients Exhibiting...

Measurement of Anti-Erythropoiesis-Stimulating Agent IgG4 Antibody as an Indicator of Antibody-Mediated Pure Red Cell Aplasia |...

Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis. « Research...

Gelsolin is expressed in early erythroid progenitor cells and negatively regulated during erythropoiesis. | Journal of Cell...

Erythropoiesis

Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. - PubMed - NCBI

Daily variations of marrow and splenic erythropoiesis, pinna epidermal cell mitosis and physical activity in C57B1/6J mice<...

Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis:...

Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin. - PubMed - NCBI

JCI - Loss of α-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates β-thalassemia

Diverse of Erythropoiesis Responding to Hypoxia and Low Environmental Temperature in Vertebrates

Molecular Biology of Erythropoiesis | SpringerLink

A Guide to Erythropoiesis - EPO Signaling and Erythroid Development

Characterization of the erythropoiesis in myelodysplasia by means of ferrokinetic studies, in vitro erythroid colony formation...

Unexpected role for p19INK4d in post-transcriptional regulation of GATA1 and modulation of human terminal erythropoiesis |...