Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.Colitis, Ulcerative: Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.Colitis, Ischemic: Inflammation of the COLON due to colonic ISCHEMIA resulting from alterations in systemic circulation or local vasculature.Colitis, Microscopic: A condition characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. This syndrome was first described in 1980 by Read and associates. Subtypes include COLLAGENOUS COLITIS and LYMPHOCYTIC COLITIS. Both have similar clinical symptoms and are distinguishable only by histology.Dextran Sulfate: Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.Colitis, Collagenous: A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show larger-than-normal band of subepithelial COLLAGEN.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Trinitrobenzenesulfonic Acid: A reagent that is used to neutralize peptide terminal amino groups.Colitis, Lymphocytic: A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show infiltration of LYMPHOCYTES in the superficial EPITHELIUM and the underlying connective tissue (lamina propria).Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Inflammatory Bowel Diseases: Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)Rectum: The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)Peroxidase: A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 126.96.36.199.Gastrointestinal Agents: Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.Colectomy: Excision of a portion of the colon or of the whole colon. (Dorland, 28th ed)Proctocolectomy, Restorative: A surgical procedure involving the excision of the COLON and RECTUM and the formation of an ILEOANAL RESERVOIR (pouch). In patients with intestinal diseases, such as ulcerative colitis, this procedure avoids the need for an OSTOMY by allowing for transanal defecation.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Colonoscopy: Endoscopic examination, therapy or surgery of the luminal surface of the colon.Dysentery, Amebic: DYSENTERY caused by intestinal amebic infection, chiefly with ENTAMOEBA HISTOLYTICA. This condition may be associated with amebic infection of the LIVER and other distant sites.Ileostomy: Surgical creation of an external opening into the ILEUM for fecal diversion or drainage. This replacement for the RECTUM is usually created in patients with severe INFLAMMATORY BOWEL DISEASES. Loop (continent) or tube (incontinent) procedures are most often employed.Administration, Rectal: The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.Enterocolitis, Pseudomembranous: An acute inflammation of the INTESTINAL MUCOSA that is characterized by the presence of pseudomembranes or plaques in the SMALL INTESTINE (pseudomembranous enteritis) and the LARGE INTESTINE (pseudomembranous colitis). It is commonly associated with antibiotic therapy and CLOSTRIDIUM DIFFICILE colonization.Pouchitis: Acute INFLAMMATION in the INTESTINAL MUCOSA of the continent ileal reservoir (or pouch) in patients who have undergone ILEOSTOMY and restorative proctocolectomy (PROCTOCOLECTOMY, RESTORATIVE).Mice, Inbred C57BLEnterocolitis: Inflammation of the MUCOSA of both the SMALL INTESTINE and the LARGE INTESTINE. Etiology includes ISCHEMIA, infections, allergic, and immune responses.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.Colonic Pouches: Sacs or reservoirs created to function in place of the COLON and/or RECTUM in patients who have undergone restorative proctocolectomy (PROCTOCOLECTOMY, RESTORATIVE).Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)Intestines: The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.Probiotics: Live microbial DIETARY SUPPLEMENTS which beneficially affect the host animal by improving its intestinal microbial balance. Antibiotics and other related compounds are not included in this definition. In humans, lactobacilli are commonly used as probiotics, either as single species or in mixed culture with other bacteria. Other genera that have been used are bifidobacteria and streptococci. (J. Nutr. 1995;125:1401-12)Interleukin-10: A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Cecum: The blind sac or outpouching area of the LARGE INTESTINE that is below the entrance of the SMALL INTESTINE. It has a worm-like extension, the vermiform APPENDIX.Citrobacter rodentium: A species of gram-negative bacteria in the genus CITROBACTER, family ENTEROBACTERIACEAE. As an important pathogen of laboratory mice, it serves as a model for investigating epithelial hyperproliferation and tumor promotion. It was previously considered a strain of CITROBACTER FREUNDII.Ileitis: Inflammation of any segment of the ILEUM and the ILEOCECAL VALVE.Feces: Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.Helicobacter hepaticus: A species of HELICOBACTER that colonizes the CECUM and COLON of several strains of MICE, and is associated with HEPATITIS and carcinogenesis.Mice, Inbred BALB CAnti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Megacolon, Toxic: An acute form of MEGACOLON, severe pathological dilatation of the COLON. It is associated with clinical conditions such as ULCERATIVE COLITIS; CROHN DISEASE; AMEBIC DYSENTERY; or CLOSTRIDIUM ENTEROCOLITIS.Ileum: The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.Oxazolone: Immunologic adjuvant and sensitizing agent.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Clostridium difficile: A common inhabitant of the colon flora in human infants and sometimes in adults. It produces a toxin that causes pseudomembranous enterocolitis (ENTEROCOLITIS, PSEUDOMEMBRANOUS) in patients receiving antibiotic therapy.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.Colon, Sigmoid: A segment of the COLON between the RECTUM and the descending colon.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Sigmoidoscopy: Endoscopic examination, therapy or surgery of the sigmoid flexure.Colonic Diseases: Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).Proctitis: INFLAMMATION of the MUCOUS MEMBRANE of the RECTUM, the distal end of the large intestine (INTESTINE, LARGE).Intestine, Large: A segment of the LOWER GASTROINTESTINAL TRACT that includes the CECUM; the COLON; and the RECTUM.Cholangitis, Sclerosing: Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.Mucous Membrane: An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)Colonic Neoplasms: Tumors or cancer of the COLON.Proctocolitis: Inflammation of the RECTUM and the distal portion of the COLON.Acute Disease: Disease having a short and relatively severe course.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Dinitrofluorobenzene: Irritants and reagents for labeling terminal amino acid groups.Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.Bacterial Translocation: The passage of viable bacteria from the GASTROINTESTINAL TRACT to extra-intestinal sites, such as the mesenteric lymph node complex, liver, spleen, kidney, and blood. Factors that promote bacterial translocation include overgrowth with gram-negative enteric bacilli, impaired host immune defenses, and injury to the INTESTINAL MUCOSA resulting in increased intestinal permeability. Bacterial translocation from the lung to the circulation is also possible and sometimes accompanies MECHANICAL VENTILATION.Mesentery: A layer of the peritoneum which attaches the abdominal viscera to the ABDOMINAL WALL and conveys their blood vessels and nerves.Clostridium Infections: Infections with bacteria of the genus CLOSTRIDIUM.Collagen Diseases: Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)CD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.Mucin-2: A gel-forming mucin found predominantly in SMALL INTESTINE and variety of mucous membrane-containing organs. It provides a protective, lubricating barrier against particles and infectious agents.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.
Cohen BA, Colas P, Brent R (Nov 1998). "An artificial cell-cycle inhibitor isolated from a combinatorial library". Proceedings ... cell visualization, and tracking cells in vivo. They can also be used to modulate activities of cell receptors and deliver ... Cell. Proteomics. 12 (7): 1939-1952. doi:10.1074/mcp.M112.024612. PMC 3708177 . PMID 23579184. Colas P.; Cohen B.; Ko Ferrigno ... Colas P.; Cohen B.; Jessen T.; Grishina I.; McCoy, J.; Brent, R. (1996). "Genetic selection of peptide aptamers that recognize ...
History of the Time Lords
ISBN 978-1-904419-73-0. Anghelides, Peter; Cole, Stephen (July 2000). The Ancestor Cell. Eighth Doctor Adventures. BBC Books. ... Cole, Stephen (writer); Briggs, Nicholas (director) (June 2000). The Apocalypse Element. Doctor Who: Main Range. Big Finish ... In The Ancestor Cell, the Eighth Doctor apparently destroys Gallifrey and retroactively wipes the Time Lords from history to ... are able to revitalise their body's cells when facing death, resulting in them completely changing their appearance and parts ...
Sherwood, Lauralee (2001). Human physiology: from cells to systems. Pacific Grove, CA: Brooks/Cole. ISBN 0-534-56826-2. OCLC ... which pumps three sodium ions out of the cell, into the interstitial fluid and two potassium ions into the cell from the ... Hu C, Rusin CG, Tan Z, Guagliardo NA, Barrett PQ (June 2012). "Zona glomerulosa cells of the mouse adrenal cortex are intrinsic ... The increased potassium level works to regulate aldosterone synthesis by depolarizing the cells in the zona glomerulosa, which ...
Sherwood, L. (2001). Human Physiology: From Cells to Systems (4th ed.). Pacific Grove, CA: Brooks-Cole. ISBN 0-534-37254-6. ... The cells that make up the primary motor cortex are Betz cells, which are a type of pyramidal cell. The axons of these cells ... Human lower motor neurons can be generated in vitro from embryonic stem cells and induced pluripotent stem cells. Betz cell ... Their cell bodies are in the ventral horn of the spinal cord and they are sometimes called ventral horn cells. A single motor ...
Some cells split via budding (for example baker's yeast), resulting in a "mother" and "daughter" cell. The offspring organism ... Kathleen M. Cole; Robert G. Sheath (1990). Biology of the red algae. Cambridge University Press. pp. 469-. ISBN 978-0-521-34301 ... In the sexual pathway, two cells fuse to form a giant cell that develops into a large cyst. When this macrocyst germinates, it ... Merogony results in merozoites, which are multiple daughter cells, that originate within the same cell membrane, sporogony ...
Cole, CN; Scarcelli, JJ (2006). "Transport of messenger RNA from the nucleus to the cytoplasm". Curr Opin Cell Biol. 18 (3): ... Görlich, Dirk; Ulrike Kutay (1999). "Transport between the cell nucleus and the cytoplasm". Annu. Rev. Cell Dev. Biol. (15): ... 2002). Molecular Biology of the Cell (4th ed.). Garland Science. Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP ... The entry and exit of large molecules from the cell nucleus is tightly controlled by the nuclear pore complexes (NPCs). ...
G-CSF factor stem-loop destabilising element
In unstimulated cells G-CSF mRNA is unstable but becomes stabilised in response to IL-1 or tumour necrosis factor alpha, and ... Putland, RA; Sassinis TA; Harvey JS; Diamond P; Coles LS; Brown CY; Goodall GJ (2002). "RNA destabilization by the granulocyte ... The G-CSF factor stem-loop destabilising element (SLDE) is an RNA element secreted by fibroblasts and endothelial cells in ... colony-stimulating factor stem-loop destabilizing element involves a single stem-loop that promotes deadenylation". Mol Cell ...
Tapas Kumar Kundu
Tapas K Kundu; Vikas B Palhan; Zhengxin Wang; Woojin An; Philip A Cole; Robert G Roeder (September 2000). "Activator-dependent ... transcription from chromatin in vitro involving targeted histone acetylation by p300". Molecular Cell. 6 (3): 551-561. doi: ... Philip A Cole (March 2000). "HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF". ...
Human physiology from cells to systems (6th ed.). Thomson Brooks/Cole. ISBN 0-495-01485-0. Stoelting, R., & Shafer, S. (2015). ... Thyroid hormone increases the number of receptors available for epinephrine at the latter's target cell, thereby increasing ... in which the presence of one hormone is required in order for another hormone to exert its full effects on a target cell. ... epinephrine's effect on that cell. Without the thyroid hormone, epinephrine would have only a weak effect. Cortisol exerts a ...
The luminal cells secrete netrin 1, which binds to the receptor neogenin (a homologue of DCC) on the cap cells. This allows for ... Bradford, Danakai; Cole, Stacey J.; Cooper, Helen M. (2009). "Netrin-1: Diversity in development". The International Journal of ... Also, the migration of adult neural progenitor cell and adult spinal cord progenitor cells to the spine is netrin 1 dependent. ... Netrins also act as growth factors, encouraging cell growth activities in target cells. Mice deficient in netrin fail to form ...
doi:10.1016/j.cell.2008.01.049. PMC 2442466 . PMID 18394996. Pedmale, Ullas V.; Huang, Shao-shan Carol; Zander, Mark; Cole, ... Cell. 164 (1-2): 233-245. doi:10.1016/j.cell.2015.12.018. PMC 4721562 . PMID 26724867. Biography and research at the Howard ... She is also an adjunct professor in the Section of Cell and Developmental Biology, UC San Diego. She obtained her bachelor's ... Cell. 74 (5): 787-799. doi:10.1016/0092-8674(93)90459-4. Larkin, Robert M.; Alonso, Jose M.; Ecker, Joseph R.; Chory, Joanne ( ...
This leads to decreased proliferation of tumor cells.Trastuzumad targets tumor cells and causes apoptosis through the immune ... Qiu C, Tarrant M, Choi S, Sathyamurthy A, Bose R, Banjade S, Pal A, Bommann W, Lemmon M, Cole P, Leahy D. (2008). "Mechanism of ... Cell. 125 (6): 1137-1149. doi:10.1016/j.cell.2006.05.013. ISSN 0092-8674. PMID 16777603. Garrett TP, McKern NM, et al. (2002 ... Lack of Schwann cell maturation leads to degeneration of motor and sensory neurons. Excessive ErbB signaling is associated with ...
Cell. 125 (6): 1137-1149. doi:10.1016/j.cell.2006.05.013. PMID 16777603. Aertgeerts, K.; Skene, R.; Yano, J.; Sang, B. -C.; Zou ... Qiu, C.; Tarrant, M. K.; Choi, S. H.; Sathyamurthy, A.; Bose, R.; Banjade, S.; Pal, A.; Bornmann, W. G.; Lemmon, M. A.; Cole, P ... Zhang, X.; Gureasko, J.; Shen, K.; Cole, P. A.; Kuriyan, J. (2006). "An Allosteric Mechanism for Activation of the Kinase ...
Cole NB, Murphy DD (2002). "The cell biology of alpha-synuclein: a sticky problem?". Neuromolecular Medicine. 1 (2): 95-109. ... It is predominantly a neuronal protein, but can also be found in the neuroglial cells. In melanocytic cells, ... Bonini NM, Giasson BI (Nov 2005). "Snaring the function of alpha-synuclein". Cell. 123 (3): 359-61. doi:10.1016/j.cell.2005.10. ... Cell. 123 (3): 383-96. doi:10.1016/j.cell.2005.09.028. PMID 16269331. Burré J, Sharma M, Tsetsenis T, Buchman V, Etherton MR, ...
A band of cells, each with multiple cilia, runs along the sides of the tentacles, connecting each tentacle to its neighbors, ... Ruppert, E.E.; Fox, R.S. & Barnes, R.D. (2004). "Mollusca". Invertebrate Zoology (7th ed.). Brooks / Cole. pp. 290-291. ISBN 0- ... These unusual cells lie around the mouth, and may provide an additional means of capturing prey. The stomach and intestine are ... This is lined with a membrane consisting of a single layer of cells, each of which has multiple cilia. The stalks of colonial ...
Skin cancer in horses
Squamous-cell carcinoma is the second-most prevalent skin cancer, followed by melanoma. Squamous-cell carcinoma and melanoma ... 422 MacGillivray, Katherine Cole; Raymond W. Sweeney; Fabio Del Piero (July 2002). "Metastatic Melanoma in Horses". Journal of ... 694 Knottenbelt and McGarry, Squamous cell carcinoma, pg. 427 Knottenbelt and McGarry. Squamous cell carcinoma., pg. 433. ... epidermal skin cells that become keratinized. Squamous-cell carcinomas are often solitary, slow-growing tumors that cause ...
"Using Coca-Cola's Distribution Muscle". "Is Coca-Cola it?". BBC. "On this week's iPM: coke, games and 'cell' phones". "Designs ... In 2008 Coca-Cola's participation at the Business Call To Action event re-kindled the idea. The active work for ColaLife was ... This Blog post did not attract Coca-Cola's attention, so Berry decided to try to get the idea debated on the BBC Radio 4 ... The organisation is not affiliated to The Coca-Cola Company (TCCC) or any other organisation and its work with others does not ...
2010). Human physiology : from cells to system. Australia ; United States: Brooks/Cole. ISBN 978-0-495-39184-5. Page 76 in: ... doi:10.1016/j.cell.2005.06.031. PMID 16051153. Johnson J, Canning J, Kaneko T, Pru J, Tilly J (2004). "Germline stem cells and ... Each type of cell behaves differently in response to FSH. Theca interna cells express receptors for luteinizing hormone (LH). ... In addition, as more estrogen is secreted, more LH receptors are made by the theca cells, inciting theca cells to create more ...
Anghelides, Peter; Cole, Stephen (July 2000). The Ancestor Cell. Eighth Doctor Adventures. BBC Books. ISBN 0-563-53809-0. ... In the Eighth Doctor Adventures novel The Ancestor Cell by Peter Anghelides and Stephen Cole, Gallifrey is destroyed as a ... The Ancestor Cell suggests that he is a future version of the Doctor, but this is retconned in The Gallifrey Chronicles, to him ... are able to revitalise their body's cells when facing death, resulting in them completely changing their appearance and parts ...
ISBN 0-495-11280-1. Alberts B, Johnson A, Lewis J, Raff M, Roberts K & Wlater P (2002). Molecular biology of the cell (4th ed ... Slabaugh, Michael R. & Seager, Spencer L. (2007). Organic and Biochemistry for Today (6th ed.). Pacific Grove: Brooks Cole. ... They may either be produced in different organs or cell types to perform the same function, or several isoenzymes may be ... This is required, for instance, to protect the secretory cell from the activity of that protein. Apoenzymes becomes active ...
2010). Human physiology : from cells to system. Australia ; United States: Brooks/Cole. ISBN 978-0-495-39184-5. Page 76 in: ... Each type of cell behaves differently in response to FSH. Theca cells express receptors for luteinizing hormone (LH). LH kicks ... The basic structure of the mature follicle has formed and no novel cells are detectable. Granulosa and theca cells continue to ... By command of an oocyte-secreted morphogenic gradient, the antral follicle's granulosa cells begin to differentiate themselves ...
... or cell receptor, receives information from outside the cell; a cell transducer processes this information across the cell ... Coles, H (October 1994). "Nobel honours pursuit of G proteins". Nature. England. 371 (6498): 547. doi:10.1038/371547b0. PMID ... could reverse the binding action of glucagon to the cell receptor and thus dissociate the glucagon from the cell altogether. He ... and the amplifier intensifies these signals to initiate reactions within the cell or to transmit information to other cells. In ...
Purton, Jared F; Boyd, Richard L; Cole, Timothy J; Godfrey, Dale I (2000). "Intrathymic T Cell Development and Selection ... Purton, Jared F; Martin, Chris E; Surh, Charles D (2008). "Enhancing T cell memory: IL-7 as an adjuvant to boost memory T-cell ... Cole, Timothy J; Godfrey, Dale I (2000). "Intrathymic T Cell Development and Selection Proceeds Normally in the Absence of ... Purton, J. F.; Tan, J. T.; Rubinstein, M. P.; Kim, D. M.; Sprent, J.; Surh, C. D. (2007). "Antiviral CD4+ memory T cells are IL ...
There have been several studies that have clearly indicated Myc's role in cell competition. A major effect of Myc is B cell ... McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD (August 1998). "The novel ATM-related protein TRRAP is an essential ... In the experimental transformation process of normal cells into cancer cells, the MYC gene can cooperate with the RAS gene. ... Cell. 142 (3): 480-93. doi:10.1016/j.cell.2010.06.037. PMC 2923036 . PMID 20691906. Nie Z, Hu G, Wei G, Cui K, Yamane A, Resch ...
Fletcher, Lisa; Kazdin, Cole (March 8, 2010). "Cell Phone Spying Nightmare: 'You're Never the Same'". ABC News. Retrieved 26 ... "Cell Phone Spying Software". Cell Phone Spying. V., Prevelakis; D., Spinellis (July 2007). "The Athens Affair". Volume:44, ... "A Cell Network Flaw Lets Hackers Drain Bank Accounts. Here's How to Fix It". wired.com. Retrieved 7 June 2017. "iPhone spying ... Intentionally hiding a cell phone in a location is a bugging technique. Some hidden cellphone bugs rely on Wifi hotspots, ...
Cole, Wendy (2007-02-16). "Cell Phones for the SpongeBob Set". TIME Magazine. "Calling All Kids". TIME Magazine. 2007-03-01. ... On May 16, 2007, Kajeet was featured in "Marketing Cell Phones to Kids," part of a five-part CBS News report on marketing to ... In July 2017, Kajeet announced that it would be shutting down and discontinuing its cell phone service on 8/23/2017 to focus on ... Kajeet has won several parenting awards for its unique cell phone service. This list of awards includes: Parent Tested, Parent ...
Cell Genet. 50 (4): 234-5. doi:10.1159/000132767. PMID 2530061. Baudier J, Cole RD (1988). "Interactions between the ... Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. ... Cell Res. 246 (2): 501-9. doi:10.1006/excr.1998.4314. PMID 9925766. Deloulme JC, Assard N, Mbele GO, Mangin C, Kuwano R, ... Cell. 3 (6): 729-39. doi:10.1016/S1097-2765(01)80005-8. PMID 10394361. Schäfer BW, Heizmann CW (1996). "The S100 family of EF- ...
Sherwood, Lauralee (2001). Human physiology: from cells to systems. Pacific Grove, CA: Brooks/Cole. ISBN 0-534-56826-2. OCLC ... Cells of the adrenal medulla are called chromaffin cells because they contain granules that stain with chromium salts, a ... Its small cells form irregular cords and clusters, separated by capillaries and connective tissue. The cells contain relatively ... ACTH acts on the adrenal cells first by increasing the levels of StAR within the cells, and then of all steroidogenic P450 ...
1156 patients with a mean of 87 CD4 cell counts and mean viral load of 100,000 copies/ml were randomized to one of the two ... Viral resistance to the drug leads to the drug becoming useless since the virus evolves to have cells that are able to resist ... There were higher CD4 cell counts and less viral load in patients assigned to the three-drug group, proving that a three-drug ... Eligible patients were those who received AZT for at least 6 months and have CD4 cell counts between 50 and 400, viral loads of ...
Cole, J.L., Hansen, J.C. Analytical Ultracentrifugation as a Contemporary Biomolecular Research Tool. Methods and Reviews, 1999 ... Cells are homogenised in a blender and filtered to remove debris. *The homogenised sample is placed in an ultracentrifuge and ... General method of fractionation: Cell sample is stored in a suspension which is: *Buffered - neutral pH, preventing damage to ... Garrett, Reginald H.; Grisham, Charles M. (2013). Biochemistry (5th ed.). Belmont, CA: Brooks/Cole, Cengage Learning. p. 111. ...
... cells in destroying these B cells. When an NK cell latched onto the cap, it had an 80% success rate at killing the cell. In ... colo-" (colonic tumor). Edrecolomab. Nacolomab tafenatox. Chimeric ("-tuxi-"). *Amatuximab§. *Bavituximab§. *Brentuximab ... The antibody binds to the cell surface protein CD20. CD20 is widely expressed on B cells, from early pre-B cells to later in ... It induces apoptosis of CD20+ cells.. The combined effect results in the elimination of B cells (including the cancerous ones) ...
... has been known to stimulate cell growth in normal and cancer cell line cultures, and it was shown that ... and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease". Proceedings of the ... on cells (including cancer cells) bestowing upon them mobility. and metastasis. It has been suggested that cancer ... stem cells, white blood cells) in many tissues and organs. SP amplifies or excites most cellular processes. ...
Taylor Cole as Vicky Roberts - a woman who Sean and Leila meet while on a cruise. She is later revealed to be an assassin ... At the same time, Michael confronts Leila over the call made using the stolen cell phone. He then kills Leila's handler as he ... At the end, Leila manages to contact Sean using a stolen cell phone and informs him of Sophia's plan. ... Taylor Cole), whom Sean and Leila met on a Caribbean cruise. Michael is told that his daughters will be killed if he does not ...
... contain glucosinolates as well as myrosinases inside their cells. When the cell is damaged, the myrosinases ... UC IPM Pest Management Guidelines Cole Crops. UC ANR Publication 3442. Oakland, CA. ... Hairs consist of one cell and occur in many forms: from simple to forked, star-, tree- or T-shaped, rarely taking the form of a ... less than 3.425 million base pairs per cell), varying from 150 Mbp in Arabidopsis thaliana and Sphaerocardamum spp., to 2375 ...
ادرار کردن - ویکیپدیا، دانشنامهٔ آزاد
When the bladder is fully distended the superficial cells become squamous (flat) and the stratification of the cuboidal cells ... Brooks/Cole Publishing Company. ISBN 978-0-8185-0388-7. Retrieved 17 October 2013.. ... transitional epithelium which contains a superficial layer of dome-like cells and multiple layers of stratified cuboidal cells ...
Mycobacterium avium subspecies paratuberculosis
DNA from a rhabdomyosarcoma cell line and a fibrosarcoma cell line transformed a NIH/3T3 mouse fibroblast cell line. After ... Trahey, M; Milley, RJ; Cole, GE; Innis, M; Patterson, H; Marshall, CJ; Hall, A; McCormick, F (1987). "Biochemical and ... cells. Downregulation of RhoA in the HBE cell lines using siRNAs showed a lack of apical junction formation in contrast with ... made seminal contributions to our understanding of cell signalling in animal cells, in particular the role of Rho and Ras small ...
Gall - Simple English Wikipedia, the free encyclopedia
Index of HIV/AIDS-related articles
T suppressor cells - T4 cell - T4 cells (T-helper cells) - T8 cells - Tanner staging - TAT - TB - template - TeachAIDS - ... colitis - combination therapy - community planning - Community Programs for Clinical Research on AIDS (CPCRA) - community-based ... B-cell lymphoma - B cells - B lymphocytes (B cells) - bactericidal - bacteriostatic - bacterium - baculovirus - baseline - ... cells - CDC National Prevention Information Network (CDC-NPIN) - cell lines - cell-mediated immunity (CMI) - cellular immunity ...
White blood cell
... ulcerative colitis, granulomatous infections (for example, tuberculosis), and chronic hepatitis ... T cells: *CD4+ helper T cells: T cells displaying co-receptor CD4 are known as CD4+ T cells. These cells have T-cell receptors ... B cells: releases antibodies and assists activation of T cells. *T cells: *CD4+ Th (T helper) cells: activate and regulate T ... Natural killer cells: virus-infected and tumor cells.. Deeply staining, eccentric. NK-cells and cytotoxic (CD8+) T-cells. Years ...
Brain-derived neurotrophic factor
cell-cell signaling. • positive regulation of brain-derived neurotrophic factor receptor signaling pathway. • collateral ... regulation of protein localization to cell surface. • regulation of receptor activity. • activation of phospholipase C activity ... BDNF binds at least two receptors on the surface of cells that are capable of responding to this growth factor, TrkB ( ... The expression of reelin by Cajal-Retzius cells goes down during development under the influence of BDNF. The latter also ...
The phagocytosis theory is based on the notion that phagocytes are cells that have the power to englobe foreign bodies - and ... Stewart Cole (Director). Website. www.pasteur.fr. Medical Center of Institut Pasteur, Paris, Rue de Vaugirard ... In 1985, the first human vaccine obtained by genetic engineering from animal cells, the vaccine against hepatitis B, was ...
Cell death may be instigated in the meibomian glands, hypothalamic cells, hippocampus cells and-important ... ulcerative colitis, but not Crohn's disease. There are also reports of people developing irritable bowel syndrome (IBS) and ... programmatic cell death) in various cells in the body. ... suppresses hippocampal cell survival in mice". Annals of the ... It is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to ...
"The expression of different superoxide dismutase forms is cell-type dependent in olive (Olea europaea L.) leaves". Plant & Cell ... For example, SOD is a highly effective experimental treatment of chronic inflammation in colitis. Treatment ... The cytosols of virtually all eukaryotic cells contain an SOD enzyme with copper and zinc (Cu-Zn-SOD). For example, Cu-Zn-SOD ... Human white blood cells use enzymes such as NADPH oxidase to generate superoxide and other reactive oxygen species to kill ...
Water vascular system
Anatomical terms of location
Royal Society of New South Wales
Their work discovered how T-cells recognize their targets and led to a much-improved understanding of the immune system ... T.W. Cole. Engineering. 1983. R.S. Vagg. Chemistry. 1984. R.S. Bhathal. Astronomy. Secretary 1989-91 ... recognises virus-infected cells. Professor Barry Jones AO FAA FAHA FTSE FASSA Dist FRSN. Politician. 2012. He was the longest ...
Place cells are also found in the hippocampus. The parietal cortex encodes spatial information using an egocentric frame of ... Cole, M.R.; Chappell-Stephenson, Robyn (2003). "Exploring the limits of spatial memory using very large mazes". Learning & ... Brun, V. H.; Otnaess, M. K.; Molden, S.; Steffenach, H.; Witter, M. P.; Moser, M.; Moser, E. I. (2002). "Place cells and place ... Participants are presented with a series of matrix patterns that have half their cells coloured and the other half blank. The ...
Urinary tract infection
... looks for the presence of red blood cells, white blood cells, or bacteria. Urine culture is deemed positive if it shows a ... Multiple white cells seen in the urine of a person with a urinary tract infection using a microscopy. ... Multiple bacilli (rod-shaped bacteria, here shown as black and bean-shaped) shown between white blood cells in urinary ... In those who have bacteria or white blood cells in their urine but have no symptoms, antibiotics are generally not needed, ...
List of atheists in science and technology
... of cells in the cell cycle.. *Mark Oliphant (1901-2000): Australian physicist and humanitarian. He played a fundamental ... K. C. Cole (2012). Something Incredibly Wonderful Happens: Frank Oppenheimer and His Astonishing Exploratorium. University of ... She is the George Barth Geller Professor of Research in Molecular Biology and Chair of the Department of Cell Biology at Duke ... Brigid Hogan FRS (1943-): British developmental biologist noted for her contributions to stem cell research and transgenic ...
"Journal of Cell Biology. 202 (3): 463-78. doi:10.1083/jcb.201211127. PMC 3734082 . PMID 23918938.. ... Dutta D, Williamson CD, Cole NB, Donaldson JG (Sep 2012). "Pitstop 2 is a potent inhibitor of clathrin-independent endocytosis" ... "J Cell Biol. 202 (3): 463-78. doi:10.1083/jcb.201211127. PMC 3734082 . PMID 23918938.. ... In a cell, a triskelion floating in the cytoplasm binds to an adaptor protein, linking one of its feet to the membrane at a ...
Mucosal cell proliferation of the rectal stump in ulcerative colitis patients after ileorectal anastomosis. | IRIS Università...
In ulcerative colitis patients the labeling index was significantly increased, and labeled cells were shifted toward the upper ... In ulcerative colitis patients the labeling index was significantly increased, and labeled cells were shifted toward the upper ... Mucosal cell proliferation of the rectal stump in ulcerative colitis patients after ileorectal anastomosis. ... Mucosal cell proliferation of the rectal stump in ulcerative colitis patients after ileorectal anastomosis. ...
Gemini Cell (Audiobook) by Myke Cole | Audible.com
Written by Myke Cole, Audiobook narrated by Korey Jackson. Sign-in to download and listen to this audiobook today! First time ... But Jim is raised from the dead by a sorcerer and recruited by a secret unit known only as the Gemini Cell. ... If you could sum up Gemini Cell in three words, what would they be? ...
Low white blood cell count - Ulcerative Colitis - HealingWell.com Forum
Ischemic Colitis in Sickle Cell Disease: A Case Report of a Diagnostic Challenge
Storm Cell: A Lewis Cole Mystery by Brendan DuBois, Hardcover | Barnes & Noble®
... defense analyst Lewis Cole must try to save a close friend from a death row murder ... In Storm Cell, Lewis Cole uncovers closely guarded secrets and makes clever use of some unwitting allies, but he still has to ... Storm Cell: A Lewis Cole Mystery. 256 by Brendan DuBoisBrendan DuBois ... Lewis Cole is at his best when hes styling himself as the not-much-to-lose wiseguy, down on his luck but not out for the count ...
Hookworm Secreted Extracellular Vesicles Interact With Host Cells and Prevent Inducible Colitis in Mice. - PubMed - NCBI
Arrows point to normal goblet cells (A,C) and goblet cell destruction (B). (1) Tissue erosion and (2) cellular infiltrates and ... Hookworm Secreted Extracellular Vesicles Interact With Host Cells and Prevent Inducible Colitis in Mice.. Eichenberger RM1, ... Hookworm Secreted Extracellular Vesicles Interact With Host Cells and Prevent Inducible Colitis in Mice ... Hookworm Secreted Extracellular Vesicles Interact With Host Cells and Prevent Inducible Colitis in Mice ...
Frontiers | Cigarette Smoking Triggers Colitis by IFN-γ+ CD4+ T Cells | Immunology
The adoptive transfer of effector T cells from CS-exposed WT mice into colitis-prone mice caused these mice to develop colitis ... of effector T cells from CS-exposed WT mice into colitis-prone mice caused these mice to develop colitis, while the AT of ... Interestingly, the colitis is mainly mediated by Th1, but not Th17, responses. CD4+ T-cell depletion or T-bet/IFN-γ deficiency ... Interestingly, the colitis is mainly mediated by Th1, but not Th17, responses. CD4+ T cell depletion or T-bet/IFN-γ deficiency ...
T-cell regulation of neutrophil infiltrate at the early stages of a murine colitis model. - PubMed - NCBI
Tacrolimus suppresses colitis directly through inhibition of T-cell activation and by suppression of T-cell-mediated ... Tacrolimus-treated wildtype mice were less sensitive to colitis and had fewer activated T-cells. Inhibition of T-cell function ... T-cell regulation of neutrophil infiltrate at the early stages of a murine colitis model.. van Lierop PP1, de Haar C, ... these drugs may impair innate immune cell recruitment and activation through inhibition of T-cells or act independent of T-cell ...
Innate lymphoid cells and colitis in leukocyte adhesion deficiency | The Journal of Immunology
Innate lymphoid cells and colitis in leukocyte adhesion deficiency. Baomei Wang, Xiaofei Li, Tetsuhiro Kajikawa, Niki M ... Innate lymphoid cells and colitis in leukocyte adhesion deficiency. Baomei Wang, Xiaofei Li, Tetsuhiro Kajikawa, Niki M ... Innate lymphoid cells and colitis in leukocyte adhesion deficiency Message Subject (Your Name) has forwarded a page to you from ... Innate lymphoid cells and colitis in leukocyte adhesion deficiency. Baomei Wang, Xiaofei Li, Tetsuhiro Kajikawa, Niki M ...
Applikon ZC3MB3000C BIOBUNDLE, 3000 ml, CELL CULTURE from Cole-Parmer
CELL CULTURE and more from our comprehensive selection of Applikon MINIBio Lab Reactor Bundles ... User can configure for both microbial and cell culture applications. Control parameters include batch, fed-batch, perfusion, ... Cole-Parmer 625 East Bunker Ct Vernon Hills , IL 60061 United States ... Mimic lab-scale bioreactors on a small scale - configure to microbial or cell culture ...
Colitis-associated cancer: the role of T cells in tumor development
... a role for the adaptive immune system has been implicated in colitis-assoc … ... Colitis-associated cancer: the role of T cells in tumor development Semin Immunopathol. 2009 Jul;31(2):249-56. doi: 10.1007/ ... a role for the adaptive immune system has been implicated in colitis-associated cancer (CAC). In fact, CD4+ effector T cells, ... This review discusses the role of the adaptive immune response and especially T cells in the pathogenesis CAC and possible ...
Antagonizing Arachidonic Acid-Derived Eicosanoids Reduces Inflammatory Th17 and Th1 Cell-Mediated Inflammation and Colitis...
... biological response modifiers and the family of cell adhesion-promoting molecules. ... During colitis, activation of two inflammatory T cell subsets, Th17 and Th1 cells, promotes ongoing intestinal inflammatory ... and IL-23), decreased percentages of Th17 cells and, improved colon injury scores (. ). Thus, during colitis, similar outcomes ... Antagonizing Arachidonic Acid-Derived Eicosanoids Reduces Inflammatory Th17 and Th1 Cell-Mediated Inflammation and Colitis ...
TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal...
Neurath and colleagues show that TH9 cells are also important for the pathogenesis of mouse and human colitis by disrupting gut ... Neurath and colleagues show that TH9 cells are also important for the pathogenesis of mouse and human colitis by disrupting gut ... The TH9 subset of helper T cells has specialized roles in parasite immunity. ... The TH9 subset of helper T cells has specialized roles in parasite immunity. ...
Colo. doctors discover link between fat cells and arthritis | FOX31 Denver
Doctors and professors at the University of Colorado School of Medicine have made a discovery linking fat cells to rheumatoid ... Colo. doctors discover link between fat cells and arthritis. Posted 9:55 am, May 8, 2013, by Brooke Way ... AURORA, Colo. - Doctors and professors at the University of Colorado School of Medicine have made a discovery linking fat cells ...
OX40 is required for regulatory T cell-mediated control of colitis | JEM
OX40 expression on T reg cells is required to suppress T cell induced colitis. RAG−/− mice received WT CD4+CD45RBhi T cells ... Our previous work has shown that T reg cells act on T cells and innate immune cells to inhibit colitis (Maloy et al., 2003). ... OX40 expression on T reg cells is required to suppress T cell-induced colitis. To determine if OX40 expression by T reg cells ... T eff cell. effector T cell. T reg cell. regulatory T cell. ... T reg cells were unable to prevent T cell-induced colitis as a ...
For those with active/recurring Fistula's - Stem Cell Treatment Results - Ulcerative Colitis - HealingWell.com Forum
HealingWell.com Forum , Diseases & Conditions , Ulcerative Colitis , For those with active/recurring Fistulas - Stem Cell ... Long-term results of adipose-derived stem cell therapy for the treatment of Crohns fistula:. www.ncbi.nlm.nih.gov/pubmed/ ... A previous phase II clinical trial of adipose-derived stem cell (ASC) therapy for fistulae associated with Crohns disease, a ... Diagnosed Crohns-Colitis 12-13 years ago - Past Meds: Antibiotics, Prednisone, Methotrexate, Imuran, Remicade - Current Meds: ...
Frontiers | Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis | Immunology
In these mice not only the Tbet deficient Tregs but also the Tbet proficient conventional T cells showed reduced IFN-gamma ... Indeed, Tbet knockout mice developed milder colitis and showed an impaired Th1 immune respon... ... Indeed, Tbet knockout mice developed milder colitis and showed an impaired Th1 immune response. ... we investigated the functional role of Th1-like Tregs in the dextran sulfate model of colitis. As observed in human IBD, Th1- ...
Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-β-deficient...
MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis. J Immunol. ... Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-β-deficient ... Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-β-deficient ... Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol. 2003; 170: 3939-3943.. *CrossRef, ...
CX3CR1+ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22 | JEM
CX3CR1+ cells protect against C. rodentium-induced colitis. To investigate the role of the expanded population of CX3CR1+ cells ... cells (Fig. 2, C- E). Depletion of CX3CR1+ cells did not affect the absolute number of ILC3 (Fig. 2 F). Although T cells can ... Intestinal CX3CR1+ cells protect mice from C. rodentium-induced colitis. (A and B) Depletion efficiency in the Cx3cr1DTR/GFP ... CX3CR1+ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. Randy S. Longman, Gretchen ...
Chronic colitis induces expression of β-defensins in murine intestinal epithelial cells
... Rahman, Arman Umeå University, Faculty ... Similarly mBD-3 was expressed in epithelial cells of DSS treated mice with chronic colitis but not in DSS treated mice with ... These cells were identified as mature plasma cells by the highly specific CD138 marker, by their prominent IgA or IgG ... Defensin expression was studied in large intestinal mucosa before and after onset of colitis in two colitis models - the IL-2 ...
Mouse Model of Colitis-Associated Colorectal Cancer (CAC): Isolation and Characterization of Mucosal-Associated Lymphoid Cells ...
Colitis-associated cancer (CAC) Azoxymethane (AOM) Lamina propria Monocyte cells (LPMCs) Intraepithelial lymphocytes (IELs) ... Mouse Model of Colitis-Associated Colorectal Cancer (CAC): Isolation and Characterization of Mucosal-Associated Lymphoid Cells ... beta-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells. Sci Transl Med 6( ... Single immune cell suspensions from lamina propria and epithelium can be purified combining selective tissue digestion and ...
Budesonide Treatment of Patients With Collagenous Colitis Restores Normal Eosinophil and T-cell Activity in the Colon
Collagenous colitis, inflammatory bowel disease, ulcerative colitis, Crohn´s disease, faecal markers, eosinophil, T-cells, ECP ... Budesonide Treatment of Patients With Collagenous Colitis Restores Normal Eosinophil and T-cell Activity in the Colon. Wagner, ... neutrophils and CD4+ as well as CD8+ T-cells in eleven patients with active collagenous colitis (CC) before and after eight ... derived from EEC cells and cells in the enteric nervous system.. We found that a normalised FC level can serve as a surrogate ...
Accumet CP-620-164 Four-electrode conductivity cell, glass, K=10.0 from Cole-Parmer
Allogeneic Adipose Tissue-derived Mesenchymal Stem Cells for the Induction of Remission in Ulcerative Colitis - Full Text View ...
... ischaemic colitis, radiation colitis, diverticular disease associated colitis, or microscopic colitis ... Allogeneic Adipose Tissue-derived Mesenchymal Stem Cells for the Induction of Remission in Ulcerative Colitis (ALOASCU). The ... Ulcerative Colitis Drug: Allogeneic adipose tissue-derived mesenchymal stem cells Phase 1 Phase 2 ... The cells will be given in different sites within the affected colonic submucosa at a total dose of 60 million cells with the ...
The effect of intestinal alkaline phosphatase on intestinal epithelial cells, macrophages and chronic colitis in mice. | Sigma...
... and on chronic colitis in interleukin-10-deficient (IL-10(-/-)) mice. Human intestinal epithelial cells COLO 205 and peritoneal ... The effect of intestinal alkaline phosphatase on intestinal epithelial cells, macrophages and chronic colitis in mice.. [ ... Oral administration of IAP significantly reduced the severity of colitis and down-regulated colitis-induced IκBα ... Colitis was quantified by histopathologic scoring, and the phosphorylation of IκBα in the colonic mucosa was assessed using ...
Cutting Edge: CD4+CD25+ Regulatory T Cells Impaired for Intestinal Homing Can Prevent Colitis | The Journal of Immunology
... mice causes colitis, which can be prevented by CD4+CD25+ regulatory T cells (Treg). Colitis induction by CD4+CD45RBhigh T cells ... Therefore, while T cell pathogenesis in this colitis model is dependent on β7 integrin expression (16), T cell-mediated ... CD45RBhigh cells) or TCRβ+CD45.2+ (from donor CD4+CD25+ cells). The composite ratios of CD4+CD45RBhigh:CD4+CD25+ T cells after ... In a previous colitis study, it was found that cotransfer of equal numbers of Treg and CD4+CD45RBhigh T cells reduced the ...
Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer | Cancer Research
Regulatory T cells (Treg) are supportive to cancer development in most tissues but their role in colitis-associated colon ... Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer. Eva Pastille, Katrin ... Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer ... Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer ...
Cancers | Free Full-Text | Overexpression of CYP3A4 in a COLO 205 Colon Cancer Stem Cell Model in vitro
We established an in vitro colon CSC-like model using the COLO 205 cell line, which revealed transiently increased expression ... Assessment of global gene expression of COLO 205 cells under these conditions identified a set of upregulated genes including ... In conclusion, this COLO 205 model provides evidence for CD133 induction concomitant with overexpression of CYP3A4, which, ... Low proliferation rates, protection in a stem cell niche and overexpression of drug resistance proteins are considered to ...
Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis
Background: Integrins are transmembrane cell surface receptors that mediate cell-cell and cell-matrix contacts. Integrin-linked ... Home » Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis ... Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis. ... In order to study how cells change their traction forces at focal adhesions (FAs) following cell contraction, we observed the ...
Effect of jiaweiwumel decoction on regulatory T cells and interleukin-10 in a rat model of ulcerative colitis. | Sigma-Aldrich
Effect of jiaweiwumel decoction on regulatory T cells and interleukin-10 in a rat model of ulcerative colitis.. [Mei Tao, Xuyan ... After peripheral blood lymphocyte separation, CD4+ T cells and CD4+/CD25+ T cell percentage was detected by flow cytometry. The ... Jiaweiwumei decoction had significant effects on regulatory T cells and IL-10 in rats with TNBS-induced ulcerative colitis. ... in a rat model of ulcerative colitis induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS). Rat ulcerative colitis was induced ...
Aldehyde Dehydrogenase-Expressing Colon Stem Cells Contribute to Tumorigenesis in the Transition from Colitis to Cancer |...
Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell 2007; 1: 389- ... Therefore, our findings indicate that the in vivo transformation of colitis cells to adenocarcinoma cells may be a useful tool ... Isolated cells were placed into a low-attachment six-well plate at a density of 2,000 to 10,000 cells per well. These cells ... We used fluorescence-activated cell sorting to identify precursor colon cancer stem cells from colitis patients and report both ...
Inflammatory bowel diInflammationIschemicColonicMicroscopicBowelMucosalSevereUlcerative colitis patientsClinicalPatientsCrohnDigestiveMicePatients with ulcerative colitisPathogenesisEffectorSulfateRegulationDendritic cellsVivoColorectalInductionSeverity of colitisTNBSMSCsCytokinesLaminaColon cancerImmunityRegulatoryInducesIntestineModelExperimentalInduceUlcerative Colitis PatientsStem cellsInnateDevelopment of colitisMETHODSLymphoidMediatorsImmune system
Inflammatory bowel di1
- Ischemic colitis occurs when blood flow to part of the large intestine (colon) is reduced, usually due to narrowed or blocked blood vessels (arteries). (mayoclinic.org)
- Ischemic colitis can cause pain and may damage your colon. (mayoclinic.org)
- Any part of the colon can be affected, but ischemic colitis usually causes pain on the left side of the belly area (abdomen). (mayoclinic.org)
- Ischemic colitis may heal on its own. (mayoclinic.org)
- But you may need medication to treat ischemic colitis or prevent infection, or you may need surgery if your colon has been damaged. (mayoclinic.org)
- Pain tends to be more severe with this type of ischemic colitis. (mayoclinic.org)
- Certain medicines also can lead to ischemic colitis, though this is rare. (mayoclinic.org)
- Conditions that affect the way the blood clots, such as Factor V Leiden, may increase the risk of ischemic colitis. (mayoclinic.org)
- Ischemic colitis usually gets better on its own within two to three days. (mayoclinic.org)
- Microscopic Colitis in Patients with Diarrhea o. (neliti.com)
- Microscopic colitis (MC) is fairly common cause of chronic non-bloody diarrhea. (neliti.com)
- Microscopic colitis which was previously regarded rare, now has emerged as a common cause of chronic diarrhea. (neliti.com)
- Microscopic colitis mainly includes two diseases, collagenous colitis (CC) and lymphocytic colitis (LC). (neliti.com)
- Randomized controlled trials (RCTs) assessing therapies for microscopic colitis have been performed. (neliti.com)
- We report a unique case of a 10-year-old Danish boy with severe small duct autoimmune sclerosing cholangitis and synchronic Crohn colitis. (biomedcentral.com)
- We present a case of a 10-year-old boy, diagnosed as AISC with an unusual, severe small duct lesion and concomitant Crohn colitis. (biomedcentral.com)
Ulcerative colitis patients2
- The proliferative activity and polyamine levels of the rectal epithelium in unoperated ulcerative colitis patients and in ulcerative colitis patients after total colectomy and ileorectal anastomosis were determined and compared with control subjects. (unifi.it)
- In ulcerative colitis patients the labeling index was significantly increased, and labeled cells were shifted toward the upper part of the crypt when compared with controls. (unifi.it)
- Hookworm Secreted Extracellular Vesicles Interact With Host Cells and Prevent Inducible Colitis in Mice. (nih.gov)
- Here, we demonstrate that CS exposure is sufficient to induce colitis in mice. (frontiersin.org)
- The adoptive transfer (AT) of effector T cells from CS-exposed WT mice into colitis-prone mice caused these mice to develop colitis, while the AT of effector T cells from IFN-γ knock-out mice did not. (frontiersin.org)
- We validated the role of the Th1 response in CS exposure-induced colitis using specific CD4 + /8 + T-cell depletion or IFN-γ/T-bet knock-out mice. (frontiersin.org)
- Finally, we confirmed that IFN-γ plays a substantial role in colitis induced by lung draining lymph node CD4 + CD25 − T-cell adoptive transfer (AT) in colitis-prone mice. (frontiersin.org)
- We assessed the effects of tacrolimus on trinitro-benzene sulphonic acid (TNBS) colitis in wildtype and Rag2-deficient mice. (nih.gov)
- Tacrolimus-treated wildtype mice were less sensitive to colitis and had fewer activated T-cells. (nih.gov)
- Rag2-deficient mice displayed an enhanced baseline level of lamina propria neutrophils that was moderately increased in TNBS colitis and remained unaffected by tacrolimus. (nih.gov)
- To answer this question, we utilized as model the CD18 −/− mice after demonstrated that CD18 deficiency renders mice highly susceptible to Citrobacter rodentium -induced colitis, a widely used model of human colitis caused by enteropathogenic and enterohaemorrhagic Escherichia coli . (jimmunol.org)
- Strikingly, we found that CD18 −/− mice displayed significantly reduced IL-22 production and IL-22 producing Group 3 innate lymphoid cells (ILC3s). (jimmunol.org)
- In an animal model, citrine reporter mice had more IL-9-expressing mucosal T cells in experimental oxazolone-induced colitis. (nature.com)
- Mice with PU.1 deficiency in T cells were protected from colitis, whereas treatment with antibody to IL-9 suppressed colitis. (nature.com)
- As observed in human IBD, Th1-like Tregs were upregulated in the inflamed lamina propria of treated mice and the expression of Tbet and IFNγ in Tregs preceded the accumulation of conventional Th1 cells. (frontiersin.org)
- Indeed, Tbet knockout mice developed milder colitis and showed an impaired Th1 immune response. (frontiersin.org)
- In these mice not only the Tbet deficient Tregs but also the Tbet proficient conventional T cells showed reduced IFNγ expression. (frontiersin.org)
- Hardenberg, G., Yao, Y., Piccirillo, C. A., Levings, M. K. and Steiner, T. S. (2012), Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-β-deficient mice. (wiley.com)
- Mouse β-defensin 3 (mBD-3, orthologue to hBD-2) was up-regulated strongly in colonic epithelium of 15-week-old IL-2(-/-) mice and DSS-induced colitis mice with chronic bowel inflammation, but not in apparently healthy IL-2(-/-) 5-week-old mice, IL-2(+/-) 15-week-old mice or in acute stage DSS mice. (diva-portal.org)
- The mRNA expression level of the constitutively expressed α-defensin, cryptdin-4, was up-regulated marginally in acute stage DSS-colitis mice and in IL-2(-/-) mice before signs of colitis. (diva-portal.org)
- O'Brien CA, Pollett A, Gallinger S, Dick JE (2007) A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. (springer.com)
- The effect of intestinal alkaline phosphatase on intestinal epithelial cells, macrophages and chronic colitis in mice. (sigmaaldrich.com)
- The aims of this study were to evaluate the effect of IAP on intestinal epithelial cells and macrophages, and on chronic colitis in interleukin-10-deficient (IL-10(-/-)) mice. (sigmaaldrich.com)
- Human intestinal epithelial cells COLO 205 and peritoneal macrophages from IL-10(-/-) mice were pretreated with IAP and then stimulated with lipopolysaccharide (LPS). (sigmaaldrich.com)
- For the in vivo study, colitis was induced in IL-10(-/-) mice with piroxicam, the mice were then treated with 100 or 300 units of IAP by oral gavage for 2 weeks. (sigmaaldrich.com)
- Oral administration of IAP significantly reduced the severity of colitis and down-regulated colitis-induced IκBα phosphorylation in IL-10(-/-) mice. (sigmaaldrich.com)
- Transfer of CD4 + CD45RB high T cells into RAG −/− mice causes colitis, which can be prevented by CD4 + CD25 + regulatory T cells (Treg). (jimmunol.org)
- The transfer of naive or CD4 + CD45RB high T cells into SCID or RAG −/− mice leads to colitis mediated by Th1 cytokines ( 1 , 2 ), and this can be prevented by cotransfer of CD4 + CD25 + regulatory T lymphocytes (Treg) 5 ( 3 ). (jimmunol.org)
- Methods: To create intestinal epithelial cell ILK knockout animals, Fabp/Cre mice )Cre recombinase expressed under the control of a modified Fabp promoter) were used, and they were mated with mice carrying a IoxP-flanked (floxed) ILK gene )lLKflox/flox). (ebscohost.com)
- In this current study, we selected ALDH+ cells from colitic patient samples to determine their potential for differentiation and their ability to generate tumors in mice. (aacrjournals.org)
- In this study, we induced DSS colitis in Th1 dominant (T-bet transgenic (Tg)) mice, Th2 dominant (GATA-3 Tg) mice, and Th17 dominant (RORγt Tg) mice to elucidate the roles of T helper cell in DSS colitis. (go.jp)
- The results showed that GATA-3 Tg mice developed the most severe DSS colitis compared with the other groups. (go.jp)
- Design The dextran sodium sulfate (DSS)-induced colitis model was used in wild-type (WT), LMIR3 −/− , mast cell-deficient Kit W-sh/W-sh , Kit W-sh/W-sh LMIR3 −/− or Kit W-sh/W-sh mice engrafted with WT or LMIR3 −/− bone marrow-derived mast cells (BMMCs). (bmj.com)
- The severity of DSS-induced colitis was assessed in mice given either an Fc fusion protein containing an extracellular domain of LMIR3, and anticeramide antibody, or ceramide liposomes. (bmj.com)
- Results LMIR3 deficiency exacerbated DSS-induced colitis in mice. (bmj.com)
- Kit W-sh/W-sh mice harbouring LMIR3 −/− mast cells exhibited more severe colitis than those harbouring WT mast cells. (bmj.com)
- Conclusions LMIR3-deficient colonic mast cells were pivotal in the exacerbation of DSS-induced colitis in LMIR3 −/− mice. (bmj.com)
- An inhibitory receptor LMIR3/CD300f suppresses immunoglobulin E-dependent and mast cell-dependent allergic responses in mice. (bmj.com)
- We used isogenic p53 +/+ and p53 −/− inflammatory cell lines as well as primary CD4 + /CD25 − effector T cells from p53 +/+ and p53 −/− mice to show that AG drives apoptosis in a p53-dependent manner. (aacrjournals.org)
- Moreover, we used a dextran sulfate sodium (DSS) model of colitis in C57BL/6 p53 +/+ and p53 −/− mice to test whether the protective effect of AG against colitis is p53 dependent. (aacrjournals.org)
- C57BL/6 p53 +/+ mice are responsive to the protective effects of AG against DSS-induced colitis, whereas AG fails to protect from colitis in p53 −/− mice. (aacrjournals.org)
- Furthermore, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling of inflammatory cells within the colonic mesenteric lymph nodes is elevated in p53 +/+ mice consuming DSS + AG but not in p53 −/− mice consuming DSS + AG. (aacrjournals.org)
- Splenic CD19(+) B cells isolated from mice infected 7 [HdBc(7(d))] and 14(d) (but not 3(d)) previously with H. diminuta and transferred to naive mice significantly reduced the severity of dinitrobenzene sulfonic acid (DNBS)-, oxazolone-, and dextran-sodium sulfate-induced colitis. (diva-portal.org)
- This study examined the pathogenesis of IBD, focusing on innate immunity using mice with spontaneous innate immune colitis. (iupui.edu)
- TNFAIP3 x RAG1-/- (TRAG) mice developed 100% penetrant colitis by 6 weeks of age that was not observed in TNFAIP3 or RAG1-/- littermates. (iupui.edu)
- Increased numbers of caspase-3+ cells were found in TRAG mice compared to RAG mice. (iupui.edu)
- This investigation suggests that cell death in TRAG mice were increased due to deficient innate immunity in IECs. (iupui.edu)
- C57BL/6 mice were randomly assigned to four groups: normal control, DSS colitis group (DSS + saline), low dose TMSC group (DSS + TMSCs 1x106), and high dose TMSC group (DSS + TMSCs 2x106). (ecco-ibd.eu)
- For the induction of acute colitis, mice were treated with 3% DSS in drinking water for 7 days. (ecco-ibd.eu)
- Using Vβ5-deficient mice, we show that these Vβ5+ iTreg cells are dispensable for limiting anti-viral immunity. (uzh.ch)
- Rather, the delayed replenishment of Treg cells in Vβ5-deficient mice compromises suppression of microbiota-dependent activation of CD8+ T cells, resulting in colitis. (uzh.ch)
- To test the hypothesis that rBmAsnRS might induce an anti-inflammatory effect in vivo , we studied the effects of rBmAsnRS in an established murine colitis model using T-cell transfer mice. (asm.org)
- T-cell transfer colitis mice treated intraperitoneally with 100 μg of rBmAsnRS four times over 2 weeks showed resolution of cellular infiltration in the colonic mucosa, along with induction of a CD8 + cellular response. (asm.org)
- Male BALB/c mice were administrated 5% DSS in distilled water for 7 days ad libitum for induction of experimental colitis. (ovid.com)
- For histological analysis of DSS-induced colitis mice, hematoxylin and eosin (HandE) staining and immunohistochemistry were performed. (ovid.com)
- Chronic colitis was induced in Bim-deficient mice (Bim(-/-) ) with dextran sulphate sodium (DSS). (uzh.ch)
- Upon chronic dextran sulphate sodium (DSS)-induced colitis, Bim(-/-) animals exhibited an increased infiltrate of lymphocytes into the mucosa compared to wild-type mice. (uzh.ch)
- The number of autoreactive T cell receptor (TCR) Vβ8(+) lymphocytes was significantly higher in Bim(-/-) mice compared to wild-type controls. (uzh.ch)
- Impaired removal of autoreactive lymphocytes in Bim(-/-) mice upon chronic DSS-induced colitis may therefore contribute to aggravated mucosal inflammation. (uzh.ch)
- Mesenchymal Stem Cells from Human Umbilical Cord Blood Decrease Ulcerative Colitis in Mice / News and Articles on Ulcerative Colitis and Crohn's Disease / Ulcerativni kolitis. (emcell.com)
- In a new study published in the journal Clinical and Experimental Pharmacology and Physiology, the researchers used umbilical mesenchymal stem cells to treat mice with ulcerative colitis induced by special drugs. (emcell.com)
- This induced colitis in mice has many in common with ulcerative colitis in humans. (emcell.com)
- When the mice with induced colitis were treated with umbilical mesenchymal stem cells, the severity of the disease in them diminished. (emcell.com)
- Treating the mice with umbilical mesenchymal stem cells lead to decrease in intestine permeability and increase in tight junction proteins levels, which are responsible for keeping the colonic cells together and ensuring the structural integrity of the colon. (emcell.com)
- To investigate the role of CHI3L1 in bacterial infectious colitis , we orally inoculated pathogenic Salmonella typhimurium and potentially pathogenic adherent-invasive Escherichia coli (AIEC) LF82 virulent strain into C57Bl/6 wild-type mice or CHI3L1 knockout (KO) mice. (curehunter.com)
- Here, upon infection with Citrobacter rodentium , a model for enteropathogenic Escherichia coli infection in humans, induced the infiltration of a large number of S100A4 + cells into the colon in wild type (WT) mice. (medicalrecords.com)
- Both EPEC and EHEC are poorly pathogenic in mice, but C . rodentium is a Gram-negative A/E bacterium that specifically infects the mouse colon epithelial cells and causes damage to the epithelial layer 10 , 11 . (medicalrecords.com)
- Therefore, infection of mice with C . rodentium is an excellent in vivo model of colitis. (medicalrecords.com)
- For this purpose, we used S100A4 knock out ( S100A4 −/− ) and wild-type (WT) mice orally challenged with C . rodentium to establish a model for studying the role of S100A4 and its related molecular mechanism in colitis. (medicalrecords.com)
- explored this connection in mice and found that CARD9 amplified Toll-like receptor signaling and subsequent cytokine production in Lyn-deficient bone marrow-derived dendritic cells, but not in macrophages. (sciencemag.org)
- Deleting Card9 or genes encoding Src family kinases in dendritic cells prevented the development of Lyn deficiency-associated colitis in mice. (sciencemag.org)
- We found that genetic deletion of CARD9 was sufficient to reduce the development of both spontaneous autoimmune disease as well as DSS- or IL-10 deficiency-associated colitis in Lyn −/− mice. (sciencemag.org)
- Dendritic cell-specific deletion of CARD9 reversed the development of autoimmune and experimental colitis observed in dendritic cell-specific, Lyn-deficient mice. (sciencemag.org)
- Omentum Cells Promote Healing of Colonic Tissues in Dextran Sulfate Sodium (DSS) Induced Model of Colitis in Mice. (nih.gov)
- C57BL/6 mice were administered 2% DSS for 10 days and then injected in the peritoneum with cells isolated from the murine omentum. (nih.gov)
- 2% DSS-mice injected with omentum cells exhibited a decrease in body weight loss, decreased inflammation in the colon and decreased levels of the inflammatory cytokine KC in the serum compared to mice given 2% DSS alone. (nih.gov)
- In addition, mice administered a lethal dose of 4% DSS exhibited a 50% decrease in mortality when injected with omentum cells. (nih.gov)
- Mice were administered 2% DSS for 10 days and then injected intraperitoneally with omentum cells (2% DSS + omentum) or PBS (2% DSS). (nih.gov)
- To determine if omentum protects against histological damage induced by DSS treatment, mice were administered 2% DSS for 10 days, injected with omentum cells and then euthanized 14 days later (day 24). (nih.gov)
- Data already produced in VilCre/pik3r1fl/fl mice given DSS colitis suggest that PI3K-mediated B-catenin activation plays a major role in wound healing. (grantome.com)
- Acute and chronic forms of DSS colitis will be generated in VilCre/pik3r1fl/fl mice for in vivo studies in AIM 1 to examine the role of IEC class 1A PI3K in mucosal healing, B-catenin activation and ISC/PC gene expression (using novel enteroid cultures). (grantome.com)
- Studies in AIM 2 utilize bone marrow chimera (BMC) mice to examine TNF-induced IEC B-catenin signaling in radioresistant epithelial populations in DSS colitis mice. (grantome.com)
- AIM 3 studies examine the role of Nox1 in B-catenin activation using B6->Nox1-/- BMC DSS colitis mice. (grantome.com)
- In this model, immunodeficient mice (RAG-/-recipients) are reconstituted with naive CD4+ T cells from healthy wild type hosts. (ucc.ie)
- These two questions will be addressed in three aims, the first two will separately address the roles of mast cell-derived histamine and IL-6 utilizing mast cell reconstitution of mast cell-deficient mice in models of colitis, and the final aim is an analysis of cellular expression of H4R and IL-6 in UC biopsies and controls. (grantome.com)
- In this research, mucus was isolated and analyzed from the intestine of healthy mice, from pigs, and from a human intestinal cell line. (medicalxpress.com)
- In addition, genetically engineered mice lacking intestinal mucus and mice with colitis were given mucus from healthy mice. (medicalxpress.com)
- Acute inflammation and recovery in wild-type (WT) and CCR9 −/− mice was studied in a model of dextran sulfate sodium (DSS)-induced colitis. (pubmedcentralcanada.ca)
- CCR9 −/− mice are more susceptible to DSS colitis than WT littermate controls as shown by higher mortality, increased IBD score and delayed recovery. (pubmedcentralcanada.ca)
- Administration of Dextran Sulfate Sodium (DSS) in drinking water induces a reversible form of colitis in mice . (pubmedcentralcanada.ca)
- The aim of this study was to further define the characteristics of Gpr83 expression and to investigate the role of Gpr83 in T(R)-cell development and function through the generation and analysis of Gpr83-deficient mice. (ox.ac.uk)
- Thymic nT(R)-cell development was unaffected by a lack of Gpr83 expression and peripheral nT(R)-cell homeostasis was normal when compared with that of wild-type mice. (ox.ac.uk)
- LY294002 inhibited mast cell and TAM-mediated tumor invasion, and in mice, blocked stromal PI3K, colitis, and cancer. (northwestern.edu)
- Results Injection of BM-MSCs reduced colitis in mice, increasing body weight and reducing markers of intestinal inflammation, compared with control mice. (elsevier.com)
- Injection of TSG6 reduced the severity of colitis in mice, along with the numbers of CD45+ cells, neutrophils and metalloproteinase activity in the mucosa, while increasing the percentage of Foxp3CD45+ cells. (elsevier.com)
- Tsg6-/- MSCs did not suppress the mucosal inflammatory response in mice with colitis. (elsevier.com)
- Conclusions BM-MSCs injected into mice with colitis do not localize to the intestine but instead form aggregates in the peritoneum where they produce immunoregulatory molecules, including TSG6, that reduce intestinal inflammation. (elsevier.com)
- TSG6 is sufficient to reduce intestinal inflammation in mice with colitis. (elsevier.com)
Patients with ulcerative colitis6
- Here we found more T cells expressing the transcription factor PU.1 and interleukin 9 (IL-9) in patients with ulcerative colitis. (nature.com)
- However, for those patients with ulcerative colitis, surveillance colonoscopy-seeking evidence of malignant transformation has proved challenging to interpret, whereas subsequent referral for surgical intervention may be controversial ( 16 , 17 ). (aacrjournals.org)
- Consistent with this hypothesis is that patients with ulcerative colitis have an elevated p53 mutation load in noncancerous colon epithelial cells ( 9 , 10 ). (aacrjournals.org)
- At UNIQUE CELL TREATMENT CLINIC we have developed schemes of suspensions containing fetal stem cells in treating patients with ulcerative colitis. (placidway.com)
- To investigate whether anxiety and depression levels are associated with Heat Shock Protein 70 (HSP70) induction in the colon of patients with ulcerative colitis (UC). (biomedcentral.com)
- Just as patients with diabetes, hypertension, or other chronic diseases have to remain aware of their conditions in order to maintain dietary and medication regimens that optimize disease management, patients with ulcerative colitis, even when in remission, may be cautiously avoiding certain stress, food, or other triggers. (wholehealthmd.com)
- As the innate immune system is also implicated in the pathogenesis of these diseases, T-cell suppressors may not only inhibit T-cell-dependent production of proinflammatory mediators but also affect innate immune cell function. (nih.gov)
- This review discusses the role of the adaptive immune response and especially T cells in the pathogenesis CAC and possible implications for the therapeutic applications. (nih.gov)
- There also is evidence from experimental models that interaction of α 4 β 7 integrin with mucosal addressin cell adhesion molecule 1 is important for colitis pathogenesis ( 16 , 17 , 18 ). (jimmunol.org)
- Ulcerative colitis (UC) is an inflammatory bowel disease, and its pathogenesis includes genetic, environmental, and immunological factors, such as T helper cells and their secreted cytokines. (go.jp)
- Mast cells are involved in the pathogenesis of IBD. (bmj.com)
- A key mechanism for immune suppression is apoptosis of overly aggressive effector T cells, and defects in mucosal T-cell apoptosis are likely to be critical in the pathogenesis of colitis. (aacrjournals.org)
- There is increasing evidence that iNKRs like NKG2A expressed on T cells are importantly involved in the regulation of immune responses though no studies have addressed the potential role in the pathogenesis of IBD. (ovid.com)
- These results suggest that inadequate local infiltration of NKG2A+ T cells may be involved in the pathogenesis of UC. (ovid.com)
- Growing evidence supports a role for T cell-mediated immune response and release of various cytokines in the pathogenesis of colitis-associated cancer (CAC). (begellhouse.com)
- Many trypsin-like serine proteases such as β-tryptase are involved in the pathogenesis of colitis and inflammatory bowel diseases. (aspetjournals.org)
- This proposal aims to determine the cellular source of histamine, along with the target cell in which H4R is activated to trigger te release of inflammatory mediators that drive UC pathogenesis. (grantome.com)
- Fetal stem cells possess immunocorrecting properties and are able to stop the pathological reaction against one's own mucosa of small and large intestines, influencing the pathogenesis (development) of the disease (ulcerative colitis). (placidway.com)
- The immune response in the gastrointestinal tract is a tightly controlled balance between effector and regulatory cell responses. (rupress.org)
- OX40 −/− T reg cells showed reduced accumulation in the colon and peripheral lymphoid organs, resulting in their inability to keep pace with the effector response. (rupress.org)
- As OX40 also promoted the colitogenic Th1 response, its expression on T reg cells may be required for effective competition with OX40-dependent effector responses. (rupress.org)
- Understanding how particular co-stimulatory pathways affect both effector T (T eff) cell and T reg cell responses is crucial for development of antiinflammatory strategies based on co-stimulatory blockade, as interventions that inhibit both types of response may not reset the immunological balance in favor of T reg cells. (rupress.org)
- Treg expanded in vivo to the same extent as CD4 + CD45RB high T cells after transfer and they did not inhibit CD4 + CD45RB high T cell expansion in lymphoid tissues, although they prevented the accumulation of Th1 effector cells in the intestine. (jimmunol.org)
- These data demonstrate that Treg can prevent colitis by inhibiting the accumulation of tissue-seeking effector cells and that Treg accumulation in the intestine is dispensable for colitis suppression. (jimmunol.org)
- Transient ablation of CD4+Foxp3+ regulatory T during tumor development in the CAC model suppressed tumor outgrowth and distribution, accompanied by an increased number of CD8+IFN-γ-/granzyme B-producing effector T cells. (aacrjournals.org)
- While quiescent T cells use oxidative phosphorylation (OXPHOS) for energy production, and effector T cells (Teffs) rely on glycolysis for proliferation, the distinct metabolic features of regulatory T cells (Tregs) are less well established. (pnas.org)
- Collectively, these data suggest that CD103+ and CD103- DCs represent functionally distinct subsets and that CD103 expression on DCs influences the balance between effector and regulatory T cell activity in the intestine. (ox.ac.uk)
- Starting from the observation that Tregs isolated from the lamina propria of active but not inactive IBD patients or uninflamed controls express Tbet and IFNγ, we investigated the functional role of Th1-like Tregs in the dextran sulfate model of colitis. (frontiersin.org)
- Moreover, S100A4 is secreted from both tumor and non-malignant cells and exerts extracellular effects regulating cell mobility, invasion, and angiogenesis by interacting with annexin II, RAGE, and heparan sulfate proteoglycans 18 , 19 , 20 . (medicalrecords.com)
- RESULTS -There was no significant difference between glargine and regular human insulin with respect to regulation of proliferation and apoptosis of Colo-357 cells. (diabetesjournals.org)
- Understanding how innate immune activation drives cell death in IECs, may lead to a better understanding of the complex regulation of IBD, and improved therapeutic agents targeting novel cell types in the remission of chronic IBD. (iupui.edu)
- Here, we demonstrate that Blimp-1 in CD103 + dendritic cells (DCs) critically contributes to the regulation of macrophage homeostasis in the colon. (springer.com)
- Filaria have often been referred to as "masters of regulation" because of their profound effect on host immunity, which includes parasite antigen-specific CD4 + T-cell hyporesponsiveness and interleukin 10 (IL-10) responses ( 10 ). (asm.org)
- As Bim is induced for the killing of autoreactive cells we determined the role of Bim in the regulation of lymphocyte survival at mucosal sites. (uzh.ch)
- IL-18 has been implicated in inflammatory bowel disease (IBD), however its role in the regulation of intestinal CD4+ T-cell function remains unclear. (dtu.dk)
- Stem cell therapy for Crohn's helps to reset and repair the immune system using lab enhanced/differentiated Hematopoietic mesenchymal stem cells that do not induce interferon-γ production, lymphocyte proliferation or up-regulation of the activation markers. (stemcellthailand.org)
- Mechanistically, CARD9 was a vital component of the Lyn-mediated regulation of Toll-like receptor (TLR2 and TLR4) signaling in dendritic cells, but not in macrophages. (sciencemag.org)
- Gpr83 expression is not required for the maintenance of intestinal immune homeostasis and regulation of T-cell-dependent colitis. (ox.ac.uk)
- Essential role for CD103 in the T cell-mediated regulation of experimental colitis. (ox.ac.uk)
- We have analyzed the functional role of CD103 in intestinal immune regulation using the T cell transfer model of colitis. (ox.ac.uk)
- However, wild-type CD4+CD25+ T cells were unable to prevent colitis in immune-deficient recipients lacking CD103, demonstrating a nonredundant functional role for CD103 on host cells in T reg cell-mediated intestinal immune regulation. (ox.ac.uk)
- Moreover, bulk assays fail to identify if a change in the expression profile is due to a change in regulation or composition, in which one cell type arises to dominate the population. (wikipedia.org)
- CX 3 CR1 + MNPs from both mouse and human tissue produced more IL-23 and IL-1β than conventional CD103 + dendritic cells (cDCs) and were more efficient than cDCs in supporting IL-22 production in ILC3 in vitro and in vivo. (rupress.org)
- In addition, dendritic cells (DCs) are important components of antitumor immunity. (begellhouse.com)
- Dendritic cells (DCs) and macrophages lacking CARD9 have signaling defects downstream of C-type lectin receptors (CLRs), nucleotide-binding oligomerization domain (NOD)-like receptors, retinoic acid-inducible gene-I (RIG)-like receptors, and Toll-like receptors (TLRs) ( 1 ). (sciencemag.org)
- We asked ourselves whether dendritic cells in the gut could capture mucus, as well as bacteria and food antigens," said Andrea Cerutti, MD, PhD, the study's senior author and Professor in the Department of Medicine at the Immunology Institute at the Icahn School of Medicine. (medicalxpress.com)
- Dendritic cells are a type of immune cell found in the mucosa that launch an immune response . (medicalxpress.com)
- Activated plasmacytoid dendritic cells (DCs) accumulate in mesenteric lymph nodes (MLNs) of CCR9 −/− animals, altering the local ratio of DC subsets. (pubmedcentralcanada.ca)
- Our results demonstrate that CCL25/CCR9 interactions regulate inflammatory immune responses in the large intestinal mucosa by balancing different subsets of dendritic cells. (pubmedcentralcanada.ca)
- Non-T cell expression of CD103 is restricted primarily to CD11c(high)MHC class II(high) dendritic cells (DCs). (ox.ac.uk)
- However, Tbet deficiency did not affect the Tregs suppressive capacity in vitro and in vivo in the adoptive transfer model of colitis. (frontiersin.org)
- Here, we show that in vivo depletion of CX 3 CR1 + mononuclear phagocytes (MNPs) resulted in more severe colitis and death after infection with Citrobacter rodentium . (rupress.org)
- These Treg were increased strongly in number in a mouse model of CAC and in the peripheral blood of colon cancer patients, exhibiting an activated phenotype as defined by elevated expression of GARP, CD103, CTLA-4 and IL-10, along with an increased suppressive effect on the proliferation and Th1 cytokine expression of CD4+CD25- responder T cells ex vivo. (aacrjournals.org)
- Results are consistent with our in vitro data and with the hypothesis that AG drives inflammatory cell apoptosis in vivo , providing a mechanism by which AG protects from colitis in this DSS mouse model. (aacrjournals.org)
- Recently, miR-133α was further examined forits role in NT-associated proinflammatory signaling cascades and acute colitis in vivo. (escholarship.org)
- Recent studies demonstrate that bone marrow-derived mesenchymal stem cells (MSCs) have potent immunoregulatory activity in vitro and in vivo. (labome.ru)
- Mechanistic insights were gained from ex vivo studies of cell interactions, the piroxicam/IL-10 -/- mouse model of progressive colitis, and use of the PI3K inhibitor LY294002. (northwestern.edu)
- Mast cells recruited macrophages in ex vivo migration assays, and both mast cells and TAMs promoted invasion of cancer cells. (northwestern.edu)
- Patients with chronic ulcerative colitis are at increased risk of developing colorectal cancer. (aacrjournals.org)
- Although current hypotheses suggest that sporadic colorectal cancer is due to inability to control cancer stem cells, the cancer stem cell hypothesis has not yet been validated in colitis-associated cancer. (aacrjournals.org)
- Recent reports showed that it was effective in curing colitis and ameliorating the major manifestations of postoperational colorectal cancer (CRC). (biomedcentral.com)
- Experimental Design: We conducted immunostaining of phosphorylated AKT (pAKT) and unbiased high-throughput image acquisition and quantitative analysis of samples of noninflamed normal colon, colitis, dysplasia, and colorectal cancer. (northwestern.edu)
- Colitis induction by CD4 + CD45RB high T cells requires β 7 integrin-dependant intestinal localization, but the importance of β 7 integrins for Treg function is unknown. (jimmunol.org)
- In this study, we have analyzed these issues by comparing transferred β 7 +/+ and β 7 −/− Treg for their ability to accumulate in different sites and their effects on cotransferred CD4 + CD45RB high T cells and colitis induction. (jimmunol.org)
- In conclusion, this COLO 205 model provides evidence for CD133 induction concomitant with overexpression of CYP3A4, which, together with ATP-binding cassette, subfamily G, member 2 (ABCG2) and others, may have a role in chemoresistant colon CSCs and a negative impact on disease-free survival in colon cancer patients. (mdpi.com)
- Induction of cell proliferation would be particularly relevant for insulin treatment of subjects with diabetes and the potential of bearing tumor cells (e.g., a history of a malignant disease). (diabetesjournals.org)
- In addition, intracolonicinjection of antisense-miR-133α before colitis induction improves histological scores and proinflammatory cytokine transcription. (escholarship.org)
- Culture of UC LPMCs with lyso-sulfatide glycolipid to determine sulfatide induction of epithelial cell cytotoxicity, IL-13 production and IL-13Rα2 expression. (uni-regensburg.de)
- Animals in the MSC treatment groups received either 1 × 10 5 , 1 × 10 6 or 3 × 10 6 MSCs by enema 3 hours after induction of colitis. (biomedcentral.com)
- HSP70 is induced in PMN cells of UC patients and its induction correlates with depression and anxiety levels. (biomedcentral.com)
Severity of colitis1
- Both the innate and the adaptive mucosal immune system contribute to TNBS colitis. (nih.gov)
- We utilized two genetic mouse models, which differentially antagonize PGE 2 levels, to examine the effect on Th17 cells and disease outcomes in trinitrobenzene sulfonic acid- (TNBS-) induced colitis. (hindawi.com)
- To investigate the effect of a decoction made from the Traditional Chinese Medicine wumei pill, on regulatory T cells and interleukin-10 (IL-10) in a rat model of ulcerative colitis induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS). (sigmaaldrich.com)
- Rat ulcerative colitis was induced with TNBS. (sigmaaldrich.com)
- Jiaweiwumei decoction had significant effects on regulatory T cells and IL-10 in rats with TNBS-induced ulcerative colitis. (sigmaaldrich.com)
- GB88) was evaluated for the blockade of intracellular calcium release in colonocytes and anti-inflammatory activity in acute (PAR2 agonist-induced) versus chronic [2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced] models of colitis in Wistar rats. (aspetjournals.org)
- Chronic TNBS-induced colitis in rats was ameliorated by GB88 (10 mg/kg/day p.o.), which reduced mortality and pathology (including colon obstruction, ulceration, wall thickness, and myeloperoxidase release) more effectively than the clinically used drug sulfasalazine (100 mg/kg/day p.o. (aspetjournals.org)
- The neuroprotective effect of MSCs in TNBS colitis is dose-dependent. (biomedcentral.com)
- Background: Mesenchymal stem cells (MSCs) are a well-established immunosuppressive agent which can also promote tissue repair and regeneration. (researchsquare.com)
- We herein compared MSCs and their associated EVs side-by-side using a DSS-induced colitis model. (researchsquare.com)
- Conclusions: These results suggest that (i) both MSCs and EVs are effective therapeutic candidates for a DSS-induced mouse colitis model, (ii) MSCs and EVs have similar immunosuppressive and anti-inflammatory functions, and (iii) EVs may present a novel future therapeutic for the treatment of IBD. (researchsquare.com)
- 18 - 22 ) These cells have proven to be safe and effective in the local treatment of Crohn's perianal fistulizing disease( 13 - 17 ) and early data from limited studies suggest MSCs may also be effective for the treatment of intestinal UC and CD. (researchsquare.com)
- Identification of mesenchymal stem cells (MSCs) isolated from feline adipose tissue. (biomedcentral.com)
- Mesenchymal stem cells (MSCs) are gaining wide recognition as a potential therapy for many diseases due to their immunomodulatory and neuroprotective qualities. (biomedcentral.com)
- A fe recent studies have reported that mouse or human MSCs attenuate the erosive, self-limiting colitis induced by the oral or rectal administration of toxic chemicals. (labome.ru)
- Therefore, we will evaluate the therapeutic efficacy of human or mouse bone marrow-derived MSCs in a well-characterized, mouse model of chronic colitis. (labome.ru)
- The infused MSCs cells help to improve the autoimmune disease by helping to promote a change in the production of pro-inflammatory cytokines to the beneficial anti-inflammatory cytokines at and near the site of injury. (stemcellthailand.org)
- IL-17, but not several other cytokines, including interferon (IFN)-γ, induced mBD-3 mRNA expression in mouse colon carcinoma cells. (diva-portal.org)
- During CAC development, immune cells, cytokines, and other immune mediators are involved in both tumorigenesis and the elimination of cancer cells during immunotherapy. (springer.com)
- In contrast, regulatory T cells (Tregs) release the immunosuppressive cytokines IL-10, TGF-β and thus have protective effects in CAC. (begellhouse.com)
- This review discusses the role of T cell-mediated immune response, and DCs and involved cytokines in the immunopathogenesis of CAC in an animal model, which may also provide future therapeutic targets in CAC. (begellhouse.com)
- Cells lacking CARD9 fail to produce cytokines upon Dectin-1 ligation and show defective fungal killing ( 4 ). (sciencemag.org)
- We found that whenever mucus was present, it was stimulating the production of anti-inflammatory cytokines [ regulatory proteins released by the cells of the immune system that act to regulate an immune response]," he added. (medicalxpress.com)
- Animal research depicts a causal relationship between experimentally induced depression and increased secretion of proinflammatory cytokines leading to reactivation of colitis. (biomedcentral.com)
- Thus, the study of mucosal immune responses (including lamina propria mononuclear cells and intraepithelial lymphocytes) is important to understand the role of the immune system during development and therapy in CRC. (springer.com)
- Single immune cell suspensions from lamina propria and epithelium can be purified combining selective tissue digestion and Percoll gradient centrifugation. (springer.com)
- Isolated splenocytes, peripheral lymph node cells, mesenteric lymph node (MLN) cells, intraepithelial lymphocyte, and lamina propria lymphocyte (LPL) were stained with PE-Cy5 or allophycocyanin anti-TCRβ (H57-597), FITC anti-CD45.1 (A20), PE anti-CD25 (PC61), and PE-Cy5 or allophycocyanin anti-CD4 (GK1.5) (BD Pharmingen). (jimmunol.org)
- Production of chemical mediators from lamina propria cells was measured by real-time reverse transcription PCR. (bmj.com)
- Various immune cell infiltrations in the epithelium and lamina propria are seen in MC immunopathology. (diva-portal.org)
- Objective: Previous studies have shown that ulcerative colitis (UC) is associated with the presence of lamina propria non-invariant (Type II) NKT cells producing IL-13 and mediating epithelial cell cytotoxicity. (uni-regensburg.de)
- Here we sought to define the antigen(s) stimulating the NKT cells and to quantitate these cells in the UC lamina propria. (uni-regensburg.de)
- These studies show that UC lamina propria is replete with Type II NKT cells responsive to lyso-sulfatide glycolipid and bearing IL-13Rα2. (uni-regensburg.de)
- Additionally, infection with these pathogens induces infiltration of immune cells and edema within the lamina propria 8 , 9 . (medicalrecords.com)
- The anti-inflammatory effect of FP7, active as TLR4 antagonist, was evaluated on peripheral blood mononuclear cells (PBMCs) and lamina propria mononuclear cells (LPMCs) isolated from IBD patients, and in a mouse model of ulcerative colitis. (springer.com)
- This model allows the examination of interactions between APCs and T cells in the lamina propria. (ucc.ie)
- Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C, De Maria R (2007) Identification and expansion of human colon-cancer-initiating cells. (springer.com)
- Regulatory T cells (Treg) are supportive to cancer development in most tissues but their role in colitis-associated colon cancer (CAC) remains unclear. (aacrjournals.org)
- We recently showed that epithelial cells with the increased expression of aldehyde dehydrogenase in sporadic colon cancer correlate closely with tumor-initiating ability. (aacrjournals.org)
- Similar to sporadic colon cancer, these colitis-derived tumors were capable of propagation as sphere cultures. (aacrjournals.org)
- Colon cancer tumor-initiating cells have been reported, using markers such as CD44 and CD133 ( 2 - 4 ). (aacrjournals.org)
- Furthermore, use of these markers to identify colon cancer-initiating cells has revealed their properties of self-renewal, multipotency, and chemoresistance. (aacrjournals.org)
- We recently showed that ALDH+ cells from colon cancer can be used as a marker for the tumor-initiating subset ( 10 ) and may reflect a chemoresistant subset within CD44+/CD166+ tumor-initiating colon cancer ( 11 ). (aacrjournals.org)
- Ulcerative colitis is a dynamic, chronic inflammatory condition associated with an increased colon cancer risk. (aacrjournals.org)
- The research proposal focuses on ulcerative colitis (UC), a type of inflammatory bowel disease (IBD), isolated to the colon, which causes chronic abdominal pain and bloody diarrhea, and ultimately, colon cancer. (grantome.com)
- CARD9 is an immune adaptor protein in myeloid cells that is involved in C-type lectin signaling and antifungal immunity. (sciencemag.org)
- Regulatory T (T(R)) cells are integral to the maintenance of intestinal homeostasis, where an intricate balance between tolerance and immunity must be maintained. (ox.ac.uk)
- Here, we have investigated the role of OX40 in influencing the balance between conventional T cells and Foxp3 + regulatory T (T reg) cells. (rupress.org)
- In normal conditions gut homeostasis is maintained by the suppressive activity of regulatory T cells (Tregs), characterized by the expression of the transcription factor FoxP3. (frontiersin.org)
- Regulatory T cells (Tregs) are a class of T cells which negatively control the pro-inflammatory activity of adaptive and innate immune cells and they play a key role in the maintenance of the gut immune homeostasis ( 2 ). (frontiersin.org)
- Effect of jiaweiwumel decoction on regulatory T cells and interleukin-10 in a rat model of ulcerative colitis. (sigmaaldrich.com)
- With the goal of harnessing the immunomodulatory capacity of infection with H. diminuta, we assessed the putative generation of anti-colitic regulatory B cells following H. diminuta infection. (diva-portal.org)
- Thus, in response to H. diminuta, a putatively unique splenic CD19(+) B cell with a functional immunoregulatory program is generated that promotes the suppression of colitis dominated by TH1, TH2, or TH1-plus-TH2 events, and may do so via the synthesis of TGF-beta and the generation of, or cooperation with, a regulatory macrophage. (diva-portal.org)
- Foxp3+ regulatory T (Treg) cells are essential for maintaining peripheral tolerance and preventing autoimmunity. (uzh.ch)
- Regulatory T cells (Tregs) play a critical role in maintaining immune tolerance to self-antigens and in suppressing excessive immune responses that may cause collateral damage to the host. (pnas.org)
- One such molecule, the G-protein coupled receptor Gpr83, has been identified through gene expression analysis as being overexpressed within thymic and peripheral naturally arising regulatory T (nT(R)) cell populations. (ox.ac.uk)
- Rather than being a general marker of activation, Gpr83 expression could only be detected in cells also expressing forkhead/winged helix transcription factor (Foxp3), further supporting the association of Gpr83 with the regulatory cell phenotype. (ox.ac.uk)
- Gpr83 expression was dispensable for the regulatory activity of nT(R) cells as Gpr83-deficient nT(R) cells could suppress the development of disease in a T-cell transfer model of colitis. (ox.ac.uk)
- Our results show no mandatory role for CD103 expression on T cells for either the development or CD4+CD25+ regulatory T (T reg) cell-mediated control of colitis. (ox.ac.uk)
- The aggregates contained macrophages and B and T cells, and produced immune-regulatory molecules including FOXP3, interleukin (IL)10, transforming growth factor-β, arginase type II, chemokine (C-C motif) ligand 22 (CCL22), heme oxygenase-1, and TSG6. (elsevier.com)
- Here, we have examined the role of OX40 in influencing the balance between T eff and T reg cells in the intestine. (rupress.org)
- The large intestine carries 80 percent of the body's immune cells . (medicalxpress.com)
- With every meal, immune cells in the intestine stand like sentries at a citadel, turning away harmful bacteria but allowing vitamins and nutrients to pass. (medicalxpress.com)
- CCL25 and CCR9 are both expressed in the large intestine and are upregulated during DSS colitis. (pubmedcentralcanada.ca)
- The only complete cure for ulcerative colitis involves the removal of the large intestine through a surgery called a colectomy. (wholehealthmd.com)
- Inhibition of T-cell function was associated with strongly diminished recruitment of infiltrating neutrophils in the colon at the early stages of this model. (nih.gov)
- The CAC model is useful to study the involvement of immune cells not only during the carcinogenesis process but, in addition, during the treatment with novel immunotherapy protocols. (springer.com)
- We established an in vitro colon CSC-like model using the COLO 205 cell line, which revealed transiently increased expression of CD133 when transferred to serum-free stem cell culture medium. (mdpi.com)
- Mechanistic studies with the DNBS model, revealed the anti-colitic HdBc(7(d)) was within the follicular B cell population and its phenotype was not dependent on IL-4 or IL-10. (diva-portal.org)
- Administration of anti-NKG2A Ab increased the number of inflammatory foci in DSS-induced colitis, suggesting the involvement of NKG2A+ T cells in this colitis model. (ovid.com)
- In this study, we evaluated intestinal 5-HT levels in the Winnie mouse model of spontaneous chronic colitis, which closely replicates UC. (edu.au)
- Methods: A DSS-induced colitis model was used. (researchsquare.com)
- HeLa cells are used as a model system to demonstrate the relation between these particles and cancer cells. (wiley.com)
- Tumor and lymphoid cell lines from a patient with carcinoma of the colon for a cytotoxicity model. (addexbio.com)
- Cells from the omentum exert anti-inflammatory and/or healing properties in the acute DSS-induced colitis model. (nih.gov)
- Rossini, V., Radulovic, K., Riedel, C.U. and Niess, J.H. (2016) 'Development of an antigen-driven colitis model to study presentation of antigens by antigen presenting cells to T cells', Journal of Visualized Experiments, (115), e54421 (11pp). (ucc.ie)
- One of the best ways to study the immunological mechanisms involved during the disease is the T cell transfer model of colitis. (ucc.ie)
- To study the potential role of antigen presenting cells (APCs) in the disease process, it is helpful to have an antigen-driven disease model, in which a defined commensal-derived antigen leads to colitis. (ucc.ie)
- An antigen driven-colitis model has hence been developed. (ucc.ie)
- In this model OT-II CD4+ T cells, that can recognize only specific epitopes in the OVA protein, are transferred into RAG-/- hosts challenged with CFP-OVA-expressing E. coli. (ucc.ie)
- It is also an ideal cell line model for sgRNA screening and validation, either individually or in pools. (creative-biogene.com)
- These results suggest a redundant role for Gpr83 in the function of T(R) cells in this model of disease. (ox.ac.uk)
- Here, we investigate whether masking their common target, protease-activated receptor 2 (PAR2), is an effective therapeutic strategy for treating acute and chronic experimental colitis in rats. (aspetjournals.org)
- These disease-modifying properties for the PAR2 antagonist in both acute and chronic experimental colitis strongly support a pathogenic role for PAR2 and PAR2-activating proteases and therapeutic potential for PAR2 antagonism in inflammatory diseases of the colon. (aspetjournals.org)
- Embryonic stem cells derived from animals, regenerative medicine using animal cells, and experimental animal models with implications for human diseases are covered as well. (springer.com)
- Notably, CS exposure was enough to induce colitis and this colitis was mainly mediated by the Th1 response, not the Th17 response. (frontiersin.org)
- The aims of our study are to evaluate the feasibility and safety of endoscopic injection of adipose tissue-derived mesenchymal stem cells in human subjects with moderate active ulcerative colitis, assessing the absence of adverse events associated to the investigational drug, and to evaluate the efficacy of the treatment to induce remission of moderate active ulcerative colitis, by improvements in disease activity index, quality of life index, and endoscopic index. (clinicaltrials.gov)
- Although the mechanisms for the increased p53 observed in inflammatory cells are not fully delineated, many key inflammatory players have been shown to induce p53. (aacrjournals.org)
- Following activation, naïve CD4(+) T cells induce Gpr83 expression in a transforming growth factor (TGF)-beta dependent manner. (ox.ac.uk)
Ulcerative Colitis Patients1
- Treatment consists in a cell suspension (5 million cells/mL) in aseptic buffered solution containing human expanded adipose-derived stem cells (eASCs) of allogeneic origin in disposable vials with no preservative agents. (clinicaltrials.gov)
- Cancer stem cells (CSCs) seem to constitute a subpopulation of tumor cells that escape from chemotherapy and cause recurrent disease. (mdpi.com)
- You go home for 10 days, come back for two weeks to harvest your stem cells. (crohnsforum.com)
- One of the more exciting treatment options undergoing trials these days it the utilization of stem cells . (crohnsforum.com)
- This thread will be dedicated to providing information about stem cells as a treatment option. (crohnsforum.com)
- Transplantation of enhanced mesenchymal stem cells also helps to restore the patients' natural immunocompetency while also stopping the degeneration of the autoimmune process from continuing. (stemcellthailand.org)
- Effects of the treatment with fetal stem cells in many diseases and conditions are far beyond the capacity of all other modern methods of treatment. (placidway.com)
- Specifically, these drugs may impair innate immune cell recruitment and activation through inhibition of T-cells or act independent of T-cell modulation. (nih.gov)
- Interleukin (IL)-22-producing group 3 innate lymphoid cells (ILC3) promote mucosal healing and maintain barrier integrity, but how microbial signals are integrated to regulate mucosal protection offered by these cells remains unclear. (rupress.org)
- Overall, these data demonstrate that Blimp-1 expression in DCs can alter an innate inflammatory response by modulating the activation of myeloid cells. (springer.com)
Development of colitis2
- Professor Alexander Smikodub Sr. is a recognized world leader in developing of methods of stem cell treatment. (placidway.com)
- There is currently no standardized technique to generate single-cell data, all methods must include cell isolation from the population, lysate formation, amplification through reverse transcription and quantification of expression levels. (wikipedia.org)
- There are several methods available to isolate and amplify cells for single-cell analysis. (wikipedia.org)
- High throughput methods are able to quickly isolate hundreds to tens of thousands of cells. (wikipedia.org)
- Under steady-state conditions, OX40 was required by T reg cells for their accumulation in the colon, but not peripheral lymphoid organs. (rupress.org)
- Activated Syk triggers the formation of a CARD9-BCL10 (B cell lymphoma/leukemia 10)-Malt1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) complex, which leads to the activation of the nuclear factor κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways ( 5 ). (sciencemag.org)
- This autoimmune disease such as pancreatitis , Fibromyalgia , Type 1 diabetes , and Idiopathic pulmonary fibrosis that causes our cells to attack the healthy immune system affecting vital functions of the digestive tract. (stemcellthailand.org)
- White blood cells (WBCs) are cells produced by the immune system that fight off infections. (bwhcrohnscolitis.org)
- However, in ulcerative colitis, the immune system is constantly activated, even without the presence of a clear invader. (wholehealthmd.com)