Chalcones: Compounds based on CHALCONE. They are important intermediates in the formation of FLAVONOIDS.Acyltransferases: Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3.Intramolecular Lyases: Enzymes of the isomerase class that catalyze reactions in which a group can be regarded as eliminated from one part of a molecule, leaving a double bond, while remaining covalently attached to the molecule. (From Enzyme Nomenclature, 1992) EC 5.5.PropiophenonesKava: Dried rhizome and roots of Piper methysticum, a shrub native to Oceania and known for its anti-anxiety and sedative properties. Heavy usage results in some adverse effects. It contains ALKALOIDS; LACTONES; kawain, methysticin, mucilage, STARCH, and yangonin. Kava is also the name of the pungent beverage prepared from the plant's roots.Phenylalanine Ammonia-Lyase: An enzyme that catalyzes the deamination of PHENYLALANINE to form trans-cinnamate and ammonia.Flavanones: A group of FLAVONOIDS characterized with a 4-ketone.Anthocyanins: A group of FLAVONOIDS derived from FLAVONOLS, which lack the ketone oxygen at the 4-position. They are glycosylated versions of cyanidin, pelargonidin or delphinidin. The conjugated bonds result in blue, red, and purple colors in flowers of plants.Morus: A plant genus of the family MORACEAE that is widely planted for shade.Humulus: A plant genus in the CANNABACEAE family. Best known for the buds of Humulus lupulus L. used in BEER.Flavonoids: A group of phenyl benzopyrans named for having structures like FLAVONES.Angelica: A plant genus of the family Apiaceae.Zingiberaceae: A plant family of the order Zingiberales, subclass Zingiberidae, class Liliopsida. It includes plants which have both flavoring and medicinal properties such as GINGER; turmeric (CURCUMA), and cardamom (ELETTARIA).Plants: Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.Pterocarpans: A group of compounds which can be described as benzo-pyrano-furano-benzenes which can be formed from ISOFLAVONES by internal coupling of the B ring to the 4-ketone position. Members include medicarpin, phaseolin, and pisatin which are found in FABACEAE.Tetrathionic Acid: A sulfuric acid dimer, formed by disulfide linkage. This compound has been used to prolong coagulation time and as an antidote in cyanide poisoning.Mercuribenzoates: Mercury-containing benzoic acid derivatives.Flavonols: A group of 3-hydroxy-4-keto-FLAVONOIDS.Photofluorography: The photography of images produced on a fluorescent screen by X-rays.Genes, Plant: The functional hereditary units of PLANTS.Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.Elaeagnaceae: A plant family of the order Rhamnales, subclass Rosidae class Magnoliopsida. The plants have a characteristic silvery or rusty-colored sheen, caused by tiny distinctive scales. Flowers have a tubular structure of four sepals. Root nodules host the Frankia (ACTINOMYCETES) nitrogen-fixing symbionts.Pigmentation: Coloration or discoloration of a part by a pigment.Plant Proteins: Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.Plants, Medicinal: Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.Medicago sativa: A plant species of the family FABACEAE widely cultivated for ANIMAL FEED.ChalconeSoybeans: An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.Mallotus Plant: A plant genus of the family EUPHORBIACEAE. Members contain fredelin type TRITERPENES, mallorepine (a cyano-pyridone), and hydrolyzable TANNINS.Rosales: An order of the ANGIOSPERMS, subclass Rosidae. Its members include some of the most known ornamental and edible plants of temperate zones including roses, apples, cherries, and peaches.Trans-Cinnamate 4-Monooxygenase: A member of the P450 superfamily, this enzyme catalyzes the first oxidative step of the phenylpropanoid pathway in higher PLANTS by transforming trans-cinnamate into p-coumarate.ButanonesFabaceae: The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of "beans" belong to this family.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Ammonia-Lyases: Enzymes that catalyze the formation of a carbon-carbon double bond by the elimination of AMMONIA. EC 4.3.1.Gene Expression Regulation, Plant: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.Alpinia: A plant genus of the family ZINGIBERACEAE. Members contain galangin, yakuchinone-A, and diarylheptanoids.Apiaceae: A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.Viola: A plant genus of the family VIOLACEAE. Some species in this genus are called bouncing bet which is a common name more often used with SAPONARIA OFFICINALIS. Members contain macrocyclic peptides.Helichrysum: A plant genus of the family ASTERACEAE. Members contain CHALCONE, helichrysetin, arenarin, and flamin.Isomerases: A class of enzymes that catalyze geometric or structural changes within a molecule to form a single product. The reactions do not involve a net change in the concentrations of compounds other than the substrate and the product.(from Dorland, 28th ed) EC 5.PropaneCoumaric Acids: Hydroxycinnamic acid and its derivatives. Act as activators of the indoleacetic acid oxidizing system, thereby producing a decrease in the endogenous level of bound indoleacetic acid in plants.Flowers: The reproductive organs of plants.Agaricales: An extensive order of basidiomycetous fungi whose fruiting bodies are commonly called mushrooms.Flavones: A group of 4-keto-FLAVONOIDS.Asteraceae: A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of "daisy" refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.PhenylpropionatesDNA, Plant: Deoxyribonucleic acid that makes up the genetic material of plants.Gefarnate: A water insoluble terpene fatty acid used in the treatment of gastrointestinal ulcers; it facilitates the healing and function of mucosal tissue.Quercetin: A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.Arabidopsis: A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Plants, Genetically Modified: PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.Pyrones: Keto-pyrans.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Alcohol Oxidoreductases: A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Thiosulfates: Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3.Inhibitory Concentration 50: The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.RNA, Plant: Ribonucleic acid in plants having regulatory and catalytic roles as well as involvement in protein synthesis.Seeds: The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.Gene Expression Regulation, Enzymologic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.Lycopersicon esculentum: A plant species of the family SOLANACEAE, native of South America, widely cultivated for their edible, fleshy, usually red fruit.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Biosynthetic Pathways: Sets of enzymatic reactions occurring in organisms and that form biochemicals by making new covalent bonds.Multigene Family: A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)Isoflavones: 3-Phenylchromones. Isomeric form of FLAVONOIDS in which the benzene group is attached to the 3 position of the benzopyran ring instead of the 2 position.Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.Light: That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.Plant Roots: The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)Enzyme Induction: An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.Monophenol Monooxygenase: An enzyme of the oxidoreductase class that catalyzes the reaction between L-tyrosine, L-dopa, and oxygen to yield L-dopa, dopaquinone, and water. It is a copper protein that acts also on catechols, catalyzing some of the same reactions as CATECHOL OXIDASE. EC 18.104.22.168.Melanins: Insoluble polymers of TYROSINE derivatives found in and causing darkness in skin (SKIN PIGMENTATION), hair, and feathers providing protection against SUNBURN induced by SUNLIGHT. CAROTENES contribute yellow and red coloration.Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Mixed Function Oxygenases: Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.Immunochemistry: Field of chemistry that pertains to immunological phenomena and the study of chemical reactions related to antigen stimulation of tissues. It includes physicochemical interactions between antigens and antibodies.Fungi: A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.Genetic Engineering: Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.Fruit: The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.EstersSequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Tobacco: A plant genus of the family SOLANACEAE. Members contain NICOTINE and other biologically active chemicals; its dried leaves are used for SMOKING.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Drug Screening Assays, Antitumor: Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Molecular Conformation: The characteristic three-dimensional shape of a molecule.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Cell Line, Tumor: A cell line derived from cultured tumor cells.Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Ultraviolet Rays: That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.Mutagenesis, Site-Directed: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.Kinetics: The rate dynamics in chemical or physical systems.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Sequence Homology, Nucleic Acid: The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.Plant Diseases: Diseases of plants.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Plant Leaves: Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.Arabidopsis Proteins: Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).RNA Interference: A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Isoenzymes: Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Chromatography, Gel: Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Extracts of B. pilosa suppressed the growth of isolated adult T-cell leukemia cells in vitro. Alternative medicine Chinese ... The plant contains the chalcone okanin and ethyl caffeate, a hydroxycinnamic acid. ... 2011). .Anti-adult T-cell leukemia effects of Bidens pilosa. International Journal of Oncology 38(4), 1163-73. PMID 21318218 ...
February 2009). "Origins and Mechanisms of miRNAs and siRNAs". Cell. 136 (4): 642-55. doi:10.1016/j.cell.2009.01.035. PMC ... Napoli C; Lemieux C; Jorgensen R (1990). "Introduction of a chimeric chalcone synthase gene into petunia results in reversible ... In eukaryotic cells, once precursor mRNA (pre-mRNA) has been transcribed from DNA, it is processed to mature mRNA. This removes ... Cell. 29 (1): 1-7. doi:10.1016/j.molcel.2007.12.010. PMID 18206964. Matzke MA; Matzke AJM (2004). "Planting the seeds of a new ...
The hydroperoxide anion and chalcone assemble in a complex with the poly-leucine catalyst before reacting to form a peroxide ... have demonstrated cytotoxic activity against human tumor cells. Juliá, S. N.; Masana, J.; Vega, J. C. (1980). ""Synthetic ... doi:10.1039/B404390C Carrea, G.; Colonna, S.; Meek, A. D.; Ottolina, G.; Roberts, S. M., "Kinetics of chalcone oxidation by ... The Juliá-Colonna Epoxidation of electron-deficient olefins was originally demonstrated with chalcones, but it was soon ...
Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. PMID ... As such, pharmacological inhibition of prostaglandin E 2 production by synthetic minor prenylated chalcones and flavonoids has ... Additionally, investigators have observed elevations in cell doubling rates for several cancer cell types in the presence of ... It has been shown that the synthesis of prostaglandin E 2 in the endothelial cells of the brain is important for inflammation- ...
... deoxychalcones in cultured cells of Glycyrrhiza echinata, a leguminous plant producing 5-deoxyflavonoids". Plant Cell Physiol. ... doi:10.1016/s0006-291x(03)00344-9. Kimura, Y.; Aoki, T.; Ayabe, S. (2001). "Chalcone isomerase isozymes with different ... Plant Cell. 16 (2): 544-54. doi:10.1105/tpc.017509. Joung, J.Y.; Kasthuri, G.M.; Park, J.Y.; Kang, W.J.; Kim, H.S.; Yoon, B.S ... Mol Cells. 15 (3): 301-6. Pichersky, E.; Gang, D.R. (2000). "Genetics and biochemistry of secondary metabolites in plants: an ...
Another use of p-coumaric acid via its thioester with coenzyme A, i.e. 4-coumaroyl-CoA, is the production of chalcones. This is ... Role of bifunctional ammonia-lyase in grass cell wall biosynthesis. Nat. Plants. 2: 16050. doi:10.1038/nplants.2016.50. PMID ... Chalcones are the precursors of all flavonoids, a diverse class of phytochemicals. Stilbenoids, such as resveratrol, are ... which are used as a structural component of plant cell walls. The phenylpropenes, including eugenol, chavicol, safrole and ...
In these parts, they are found predominantly in outer cell layers such as the epidermis and peripheral mesophyll cells. Most ... chalcone synthase (CHS), and chalcone isomerase (CHI). Then, the next pathway is catalyzed, resulting in the formation of ... The many benefits to using dye-sensitized solar cells instead of traditional p-n junction silicon cells, include lower purity ... Anthocyanins fluoresce, enabling a tool for plant cell research to allow live cell imaging without a requirement for other ...
Plant secondary metabolism
... and this is then combined with malonyl-CoA to produce chalcones which are backbones of Flavonoids Chalcones are aromatic ... It has also been found to induce tumor growth of the estrogen receptor cells in the breast. But, one role of estrogens which ... The closure of chalcones causes the formation of the flavonoid structure. Flavonoids are also closely related to flavones which ... An important antiparasitic action is caused by the block of the transport of iodide of animal cells inhibiting sodium-iodide ...
Lian S, Jakymiw A, Eystathioy T, Hamel J, Fritzler M, Chan E (2006). "GW bodies, microRNAs and the cell cycle". Cell Cycle. 5 ( ... Van Blokland R, Van der Geest N, Mol JN, Kooter JM (1994). "Transgene-mediated suppression of chalcone synthase expression in ... RNAi is a valuable research tool, both in cell culture and in living organisms, because synthetic dsRNA introduced into cells ... In plants, RNAi is thought to propagate by the transfer of siRNAs between cells through plasmodesmata (channels in the cell ...
Hinderer W, Seitz HU (1985). "Chalcone synthase from cell suspension cultures of Daucus carota L". Arch Biochem Biophys. 240 (1 ... Chalcone synthase or naringenin-chalcone synthase (CHS) is an enzyme ubiquitous to higher plants and belongs to a family of ... Whitehead JM, Dixon RA (1983). "Chalcone synthase from cell suspension cultures of Phaseolus vulgaris". Biochim Biophys Acta. ... Cain CC, Saslowsky DE, Walker RA, Shirley BW (October 1997). "Expression of chalcone synthase and chalcone isomerase proteins ...
... can spontaneously cyclize to naringenin (a flavanone). In plant cells, this process is catalyzed by ... Naringenin chalcone is a common chalconoid (or chalcone, not to be confused with the compound chalcone). It is synthesized from ... 4-coumaroyl-CoA and malonyl-CoA by chalcone synthase (CHS), a key enzyme in the phenylpropanoid pathway. ...
Chalcone synthase (E.C. 22.214.171.124), also known as naringenin-chalcone synthase, is responsible for the reaction: 3 malonyl-CoA ... For Cell and Molecular Biology. 17 (2): 119-130. doi:10.1046/j.1365-313x.1999.00352.x. ISSN 0960-7412. PMID 10074711. "KCS1 - 3 ... Both chalcone synthases and stilbene synthases will catalyze the same acyl transfer, decarboxylation, and condensation steps as ... These enzymes are normally classified as either chalcone synthases, stilbene synthases, or type III PKSs. Overall, there are 10 ...
Wu, Peiwen; Hwang, Kevin; Lan, Tian; Lu, Yi (2013-04-10). "A DNAzyme-Gold Nanoparticle Probe for Uranyl Ion in Living Cells". ... The copper - DNA complex catalysed a Diels-Alder reaction in water between cyclopentadiene and an aza chalcone. The reaction ... With the exception of ribozymes, nucleic acid molecules within cells primarily serve as storage of genetic information due to ... Asthma is characterized by eosinophil-induced inflammation motivated by a type 2 helper T cell (Th2). By targeting the ...
M. A.; Magee A. I. (2007). "Optical techniques for imaging membrane lipid microdomains in living cells". Cell Dev. Biol. 18 (5 ... Wesołowska, O; Gąsiorowska, J.; Petrus, J.; Czarnik-Matusewicz, B.; Michalak, K. (2013). "Interaction of prenylated chalcones ... When Laurdan is located in the cell membrane its emission maximum is centered at 440 nm in gel-phase, and at 490 nm in liquid- ... Laurdan has the advantage of being able to be applied to living cells and therefore is able to provide information from complex ...
Both of these methods target specific brain circuits and cell population to influence cell activity. However, they use ... Chemogenetics as a term was originally coined to describe the observed effects of mutations on chalcone isomerase activity on ... Cells' activity, having these channels, can then be manipulated by light. Chemogenetics, on the other hand, uses chemically ... Unlike classic DREADDs, this method is usually used in wild type animals, and these receptors are given to the targeted cells ...
Cullen LM, Arndt GM (June 2005). "Genome-wide screening for gene function using RNAi in mammalian cells". Immunology and Cell ... Van Blokland R, Van der Geest N, Mol JN, Kooter JM (1994). "Transgene-mediated suppression of chalcone synthase expression in ... RNAi is a valuable research tool, both in cell culture and in living organisms, because synthetic dsRNA introduced into cells ... In plants, RNAi is thought to propagate by the transfer of siRNAs between cells through plasmodesmata (channels in the cell ...
Interferencia de ARN, a enciclopedia libre
Lian S, Jakymiw A, Eystathioy T, Hamel J, Fritzler M, Chan E (2006). "GW bodies, microRNAs and the cell cycle". Cell Cycle 5 (3 ... "Transgene-mediated suppression of chalcone synthase expression in Petunia hybrida results from an increase in RNA turnover" ... Cullen L, Arndt G (2005). "Genome-wide screening for gene function using RNAi in mammalian cells". Immunol Cell Biol 83 (3): ... Molecular Cell Biology (5th ed.). ISBN 978-0716743668..  *↑ Matranga C, Tomari Y, Shin C, Bartel D, Zamore P (2005). " ...
Lian S, Jakymiw A, Eystathioy T, Hamel J, Fritzler M, Chan E (2006). "GW bodies, microRNAs and the cell cycle". Cell Cycle. 5 ( ... Van Blokland R, Van der Geest N, Mol JN, Kooter JM (1994). "Transgene-mediated suppression of chalcone synthase expression in ... Cullen LM, Arndt GM (June 2005). "Genome-wide screening for gene function using RNAi in mammalian cells". Immunology and Cell ... In plants, RNAi is thought to propagate by the transfer of siRNAs between cells through plasmodesmata (channels in the cell ...
Dye-sensitized solar cells. Anthocyanins have been used in organic solar cells because of their ability to convert light ... The chalcone is subsequently isomerized by the enzyme chalcone isomerase to the prototype pigment naringenin, ... Anthocyanins fluoresce, enabling a tool for plant cell research to allow live cell imaging without a requirement for other ... In these parts, they are found predominantly in outer cell layers such as the epidermis and peripheral mesophyll cells. ...
CHO cells. DHFR lacking CHO cells are the most commonly used cell line for the production of recombinant proteins. These ... chalcones, deoxybenzoins, to name but a few. ... which are important for cell proliferation and cell growth. ... regulation of transcription involved in G1/S transition of mitotic cell cycle. • tetrahydrofolate metabolic process. • ... DHFR is responsible for the levels of tetrahydrofolate in a cell, and the inhibition of DHFR can limit the growth and ...
... also encodes a R2R3 type of Myb domain protein that regulates the expression of chalcone synthase, chalcone isomerase and ... Cell Genet. 41 (3): 129-35. doi:10.1159/000132217. PMID 3007038. Slamon DJ, Boone TC, Murdock DC, Keith DE, Press MF, Larson RA ... Cell. Biol. 18 (5): 2729-37. PMC 110652 . PMID 9566892. Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, ... Cell. 2 (4): 417-25. doi:10.1016/S1097-2765(00)80141-0. PMID 9809063. Thompson MA, Rosenthal MA, Ellis SL, Friend AJ, Zorbas MI ...
Le Bail JC, Pouget C, Fagnere C, Basly JP, Chulia AJ, Habrioux G (January 2001). "Chalcones are potent inhibitors of aromatase ... The aromatase enzyme can be found in many tissues including gonads (granulosa cells), brain, adipose tissue, placenta, blood ... Lambard S, Carreau S (October 2005). "Aromatase and oestrogens in human male germ cells". International Journal of Andrology. ... Apigenin, Catechin, Chalcones, Eriodictyol, Isoliquiritigenin, Mangostin, Myosmine, Nicotine, Resveratrol, Vitamin E, Zinc, ...
8-Prenylnaringenin can be produced from isoxanthohumol by flora in the human intestine, and by fungi in cell cultures. This ... Xanthohumol, the corresponding prenylated chalcone Possemiers S, Bolca S, Grootaert C, Heyerick A, Decroos K, Dhooge W, De ... "Production of 8-Prenylnaringenin from Isoxanthohumol through Biotransformation by Fungi Cells". Journal of Agricultural and ...
ಆರ್ಎನ್ಎ ಹಸ್ತಕ್ಷೇಪ - ವಿಕಿಪೀಡಿಯ
Lian S, Jakymiw A, Eystathioy T, Hamel J, Fritzler M, Chan E (2006). "GW bodies, microRNAs and the cell cycle". Cell Cycle. 5 ( ... "Transgene-mediated suppression of chalcone synthase expression in Petunia hybrida results from an increase in RNA turnover" ... Cullen L, Arndt G (2005). "Genome-wide screening for gene function using RNAi in mammalian cells". Immunol Cell Biol. 83 (3): ... Cell. 123 (4): 631-40. doi:10.1016/j.cell.2005.10.022. PMID 16271387.. CS1 maint: Multiple names: authors list (link) ...
"The Plant Cell. 9 (10): 1767-1780. doi:10.1105/tpc.9.10.1767. PMC 157020. PMID 12237347.. ... Tetrahydroxychalcone is then converted into naringenin using chalcone isomerase. Naringenin is converted into eriodictyol using ... A colorful model for genetics, biochemistry, cell biology, and biotechnology". Plant Physiology. 126 (2): 485-93. doi:10.1104/ ... van der Woude H, Ter Veld MG, Jacobs N, van der Saag PT, Murk AJ, Rietjens IM (2005). "The stimulation of cell proliferation by ...
positive regulation of T-helper cell differentiation. • transcription from RNA polymerase II promoter. • mitotic cell cycle. • ... also encodes a R2R3 type of Myb domain protein that regulates the expression of chalcone synthase, chalcone isomerase and ... positive regulation of smooth muscle cell proliferation. • positive regulation of glial cell proliferation. • cellular response ... positive regulation of hepatic stellate cell proliferation. • positive regulation of hepatic stellate cell activation. • ...
Soia, a enciclopedia libre
The aromatase enzyme can be found in many tissues including gonads (granulosa cells), brain, adipose tissue, placenta, blood ... Le Bail JC, Pouget C, Fagnere C, Basly JP, Chulia AJ, Habrioux G (January 2001). "Chalcones are potent inhibitors of aromatase ... Lambard S, Carreau S (October 2005). "Aromatase and oestrogens in human male germ cells". International Journal of Andrology. ... "Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines". Toxicology. 262 (3): 184-91. doi:10.1016/j ...
Laboratory studies indicate that flavonoids have effects on isolated cells or cell cultures in vitro, but there is no such ... chalcones, flavonols, flavanones, flavan-3-ols, flavanonols, flavones, and isoflavonoids. Furthermore, flavonoids can be ... and to modify intracellular signaling pathways in immune cells, or in brain cells after a stroke. ... They may also act as chemical messengers, physiological regulators, and cell cycle inhibitors. Flavonoids secreted by the root ...
The cellular structures of fruits and vegetables are foams with a closed cell geometry filled with a gel, surrounded by cell ... stimulate production of T helper cells, antibodies, leukocytes, cytokines, and lymph mechanisms having crucial roles in immune ... Butyric acid appears to be used as a fuel by the colonic mucosa as the preferred energy source for colonic cells. ... The cells of cooked potatoes and legumes are gels filled with gelatinized starch granules. ...
Ribonuklein turşusu - Vikipediya
Cooper G. C., Hausman R. E. (2004). The Cell: A Molecular Approach (3rd edition). Sinauer (ing.)az.. 261-276. ISBN 0-87893-214- ... Napoli C, Lemieux C, Jorgensen R. (1990). "Introduction of a chimeric chalcone synthase gene into petunia results in reversible ... King T. H., Liu B., McCully R. R., Fournier M. J. (2002). "Ribosome structure and activity are altered in cells lacking snoRNPs ... Molecular Biology Of The Cell, 4-е издание, 2002 г. - учебник по молекулярной биологии на английском языке ...
Naturally occurring phenols
Browning associated with oxidation of phenolic compounds has also been given as the cause of cells death in calli formed in in ... In conifers (Pinophyta), phenolics are stored in polyphenolic parenchyma cells, a tissue abundant in the phloem of all conifers ... Carnachan, S. M.; Harris, P. J. (2000). "Ferulic acid is bound to the primary cell walls of all gymnosperm families". ... Krokene, P.; Nagy, N. E.; Krekling, T. (2008). "Traumatic Resin Ducts and Polyphenolic Parenchyma Cells in Conifers". Induced ...
ՌՆԹ - Վիքիպեդիա՝ ազատ հանրագիտարան
46,0 46,1 Alberts, Bruce (2002). Molecular Biology of the Cell; Fourth Edition. New York and London: Garland Science. էջեր 302- ... Napoli C, Lemieux C, Jorgensen R (1990)։ «Introduction of a chimeric chalcone synthase gene into petunia results in reversible ... 48,0 48,1 48,2 Cooper GC, Hausman RE (2004). The Cell: A Molecular Approach (3rd edition տպ.). Sinauer. էջեր 261-76, 297, 339- ... Nudler E, Gottesman ME (2002)։ «Transcription termination and anti-termination in E. coli»։ Genes to Cells 7 (8): 755-68։ PMID ...
پلیفنل - ویکیپدیا، دانشنامهٔ آزاد
Locke, M.; Krishnan, N. (1971). "The distribution of phenoloxidases and polyphenols during cuticle formation". Tissue and Cell ... As opposed to smaller phenols, polyphenols are often larger molecules (macromolecules) deposited in cell vacuoles. The upper ... Krasnow, M. N.; Murphy, T. M. (2004). "Polyphenol Glucosylating Activity in Cell Suspensions of Grape (Vitis vinifera)". ... rapidly diffuse across cell membranes so that they can reach intracellular sites of action or remain as pigments once the cell ...
Dye-sensitized solar cellsEdit. Anthocyanins have been used in organic solar cells because of their ability to convert light ... The chalcone is subsequently isomerized by the enzyme chalcone isomerase to the prototype pigment naringenin, ... Anthocyanins fluoresce, enabling a tool for plant cell research to allow live cell imaging without a requirement for other ... In these parts, they are found predominantly in outer cell layers such as the epidermis and peripheral mesophyll cells. ...
... chalcone synthase (naringenin-chalcone synthase), E6, chalcone isomerase, E7, Flavonoid 3'-hydroxylase, E8, flavonone 3- ... Fluorescence-lifetime imaging microscopy (FLIM) can be used to detect flavanols in plant cells Recent study tested catechins ... A Colorful Model for Genetics, Biochemistry, Cell Biology, and Biotechnology. Plant Physiol. Vol. 126, 2001, p. 485-493. "FDA ... and protection of cells from premature aging, antioxidant activity, antioxidant content and antioxidant properties, and ...
Cell. 127 (6): 1109-22. doi:10.1016/j.cell.2006.11.013. PMID 17112576. CS1 maint: Multiple names: authors list (link) Beher D, ... cDNA, genomic clones and relationship with chalcone synthase". Eur. J. Biochem. 172 (1): 161-9. doi:10.1111/j.1432-1033.1988. ... In cells treated with resveratrol, an increase is observed in the action of MnSOD (SOD2) and in GPER activity. One way of ... "Resveratrol amplifies profibrogenic effects of free fatty acids on human hepatic stellate cells". Hepatol. Res. 39 (6): 601-8. ...
Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones - Paniego - 2001 - European...
Whitehead, I.M. & Dixon, R.A. ( 1983) Chalcone synthase from cell suspension cultures of Phaseolus vulgaris. Biochem. Biophys. ... Welle, R. & Grisebach, H. ( 1987) Purification and properties of chalcone synthase from cell suspension cultures of soy bean. Z ... Zuurbier, K.W.M., Fung, S.-Y., Scheffer, J.J.C. & Verpoorte, R. ( 1993) Assay of chalcone synthase activity by high-performance ... Okada, Y. ( 1998) A chalcone-synthase-like gene expressed specifically in lupulin gland of hop (Humulus lupulus). DDBJ/EMBL/ ...
Synthesis of chalcones with antiproliferative activity on the SH-SY5Y neuroblastoma cell line: Quantitative Structure-Activity...
... being especially appealing for their antiproliferative effects on several cancer cell lines. For this reason, we... ... Chalcones are a group of molecules with a broad spectrum of biological activities, ... Synthesis of chalcones with antiproliferative activity on the SH-SY5Y neuroblastoma cell line: Quantitative Structure-Activity ... Zi X, Simoneau AR (2005) Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by ...
Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia. | Sigma...
Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia.. [Mattia ... and synthetized the chalcone-derivative 8 possessing Notch inhibitory activity at low micro molar concentration in T-ALL cell ... Short term treatments with compound 8 resulted in a dose-dependent decrease of Notch signaling activity, halted cell cycle ... Structure-activity relationships were afforded for the chalcone scaffold. ...
Antiproliferative Evaluation In Vitro of a New Chalcone Inducing Apoptosis by ROS Generation Against MGC-803 Cells |...
... chalcone 5) against MGC-803 cells. This chalcone analog displayed a potent... ... Treatment with NAC almost completely attenuated chalcone-induced cell inhibition and cell apoptosis in MGC-803 cells, ... chalcone 5) against MGC-803 cells. This chalcone analog displayed a potent antiproliferative activity with an IC50 value of ... Antiproliferative Evaluation In Vitro of a New Chalcone Inducing Apoptosis by ROS Generation Against MGC-803 Cells. ...
IJMS | Free Full-Text | Synthetic Chalcones with Potent Antioxidant Ability on H2O2-Induced Apoptosis in PC12 Cells | HTML
These data present a series of novel chalcone analogs, especially compounds 1 and 1d, as candidates for treating oxidative ... The majority of the derivatives exhibited strong protective effects on PC12 (PC12 rat pheochromocytoma) cells exposed to H2O2, ... in PC12 cells. Inhibition of GCLC and HO-1 by specific inhibitors, l-buthionine-S-sulfoximine (BSO) and zinc protoporphyrin ( ... we further designed and synthesized a series of chalcone derivatives based on 1 and 2, to explore their antioxidant efficacy. ...
Abstract 2125: Flavokawain A, a kava chalcone, inhibits growth and invasion of human osteosarcoma cells by targeting Skp2 |...
Abstract 2125: Flavokawain A, a kava chalcone, inhibits growth and invasion of human osteosarcoma cells by targeting Skp2. ... Flavokawain A (FKA), a major chalcone from kava extract, has been reported to have antitumor effects on multiple cancer cell ... Flavokawain A, a kava chalcone, inhibits growth and invasion of human osteosarcoma cells by targeting Skp2 [abstract]. In: ... Abstract 2125: Flavokawain A, a kava chalcone, inhibits growth and invasion of human osteosarcoma cells by targeting Skp2 ...
Flavokawain A, a Novel Chalcone from Kava Extract, Induces Apoptosis in Bladder Cancer Cells by Involvement of Bax Protein...
EJ cell line was thought to be the derivative of T24 cells ( 31). However, EJ but not T24 cells can grow in soft agar and nude ... T24 and EJ cells are three to four times more sensitive to the treatment of the kava extract than RT4 cells. Figure 1C to E ... RT4 cell line with wild-type p53 was derived from recurrent, superficial bladder tumor ( 24). T24 and EJ cells with mutant p53 ... Flavokawain A, a Novel Chalcone from Kava Extract, Induces Apoptosis in Bladder Cancer Cells by Involvement of Bax Protein- ...
Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of...
Here, we show that xanthohumol at a concentration of 25 µM induced apoptosis in two HCC cell lines (HepG2 and Huh7). ... Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of ... Xanthohumol, the major prenylated chalcone found in hops, is well known to exert anti-cancer effects, but information regarding ... Dorn, C., Weiss, T.S., Heilmann, J., & Hellerbrand, C. (2010). Xanthohumol, a prenylated chalcone derived from hops, inhibits ...
In vitro inhibitory properties of ferrocene-substituted chalcones and aurones on bacterial and human cell cultures - Dalton...
Two series of ten chalcones and ten aurones, where ferrocene replaces the C ring and with diverse substituents on the A ring ... chalcones. and aurones. on bacterial and human cell cultures Keshri Nath Tiwari,a Jean-Philippe Monserrat,a Arnaud Hequet,a ... chalcones. and aurones. on bacterial and human cell cultures K. N. Tiwari, J. Monserrat, A. Hequet, C. Ganem-Elbaz, T. Cresteil ... also showed low micromolar (IC50) activity against MRC-5 non-tumoral lung cells and MDA-MB-231 breast cancer cells, suggesting ...
Prenylated chalcone xanthohumol associates with histones in breast cancer cells: a novel target identified by a monoclonal...
Prenylated chalcone xanthohumol associates with histones in breast cancer cells: a novel target identified by a monoclonal ... "Prenylated Chalcone Xanthohumol Associates with Histones in Breast Cancer Cells: a Novel Target Identified by a Monoclonal ... "Prenylated Chalcone Xanthohumol Associates with Histones in Breast Cancer Cells: a Novel Target Identified by a Monoclonal ... "Prenylated Chalcone Xanthohumol Associates with Histones in Breast Cancer Cells: a Novel Target Identified by a Monoclonal ...
Synthesis and Structure-activity Relationships of Chalcone Derivatives as Inhibitors of Ovarian Cancer Cell Growth | Bentham...
Synthesis and Structure-activity Relationships of Chalcone Derivatives as Inhibitors of Ovarian Cancer Cell Growth. Author(s): ... Title:Synthesis and Structure-activity Relationships of Chalcone Derivatives as Inhibitors of Ovarian Cancer Cell Growth ... "Synthesis and Structure-activity Relationships of Chalcone Derivatives as Inhibitors of Ovarian Cancer Cell Growth", Letters in ... Natural chalcones as well as their synthetic derivatives have shown biological activity in a number of areas including the ...
Inhibitory effects of 2-hydroxy chalcone and other flavonoids on human cancer cell proliferation | [email protected]
RNA-mediated RNA degradation and chalcone synthase A silencing in petunia. - PubMed - NCBI
Cell. 1997 Mar 21;88(6):845-54. Research Support, Non-U.S. Govt ... Cell. 1997 Mar 21;88(6):845-54.. RNA-mediated RNA degradation ... and chalcone synthase A silencing in petunia.. Metzlaff M1, ODell M, Cluster PD, Flavell RB. ... Petunia plants with a chsA coding sequence under the control of a 35S promoter sometimes lose endogene and transgene chalcone ...
The Dominant Inhibitory Chalcone Synthase Allele C2-Idf (Inhibitor diffuse) From Zea mays (L.) Acts via an Endogenous RNA...
2004 Tissue-specific gene silencing mediated by a naturally occurring chalcone synthase gene cluster in Glycine max. Plant Cell ... Niesbach-Klösgen, U., E. Barzen, J. Berhardt, W. Rohde, Z. Schwarz-Sommer et al., 1987 Chalcone synthase genes in plants: a ... Franken, P., U. Niesbach-Klosgen, U. Weydemann, L. Marechal-Drouard, H. Saedler et al., 1991 The duplicated chalcone synthase ... AY728478 [c2 gene chalcone synthase (wild type) C2-W22], AY728476 (Zea mays L. C2-Idf allele; gene copies C2-Idf-I and C2-Idf- ...
Chalcone synthase - Wikipedia
Hinderer W, Seitz HU (1985). "Chalcone synthase from cell suspension cultures of Daucus carota L". Arch Biochem Biophys. 240 (1 ... Chalcone synthase or naringenin-chalcone synthase (CHS) is an enzyme ubiquitous to higher plants and belongs to a family of ... Whitehead JM, Dixon RA (1983). "Chalcone synthase from cell suspension cultures of Phaseolus vulgaris". Biochim Biophys Acta. ... Cain CC, Saslowsky DE, Walker RA, Shirley BW (October 1997). "Expression of chalcone synthase and chalcone isomerase proteins ...
Distribution of Flavonoids and Cyclohexenyl Chalcone Derivatives in Conventional Propagated and In Vitro-Derived Field-Grown...
J.-M. Yun, M.-H. Kweon, H. Kwon, J.-K. Hwang, and H. Mukhtar, "Induction of apoptosis and cell cycle arrest by a chalcone ... 11, 12] reported that panduratin D was cytotoxic against pancreatic cancer cells. Interestingly, cyclohexenyl chalcones derived ... The presence of pinostrobin chalcone was scarce, suggesting its intermediate role in the conversion of pinocembrin chalcone to ... These derivatives included 4-hydroxypanduratin A, panduratin A, cardamonin, pinostrobin chalcone, and pinocembrin chalcone. 4- ...
RNA Interference Silencing of Chalcone Synthase, the First Step in the Flavonoid Biosynthesis Pathway, Leads to Parthenocarpic...
The epidermal cell layer of the wild-type fruits consisted of intact cells with a typical conical shape (Fig. 8, A and B ), ... chalcone isomerase-overexpressing fruits display reduced NAR-chalcone levels, a more intense red color, and a dull appearance ... fruits the epidermal cell layer is disturbed (absence of conical shapes and empty cells). ... 7D) compared to wild type due to the absence of NAR-chalcone as a result of Chs RNAi inhibition (Fig. 5A). It is likely that ...
Naringenin chalcone - Wikipedia
Naringenin chalcone can spontaneously cyclize to naringenin (a flavanone). In plant cells, this process is catalyzed by ... Naringenin chalcone is a common chalconoid (or chalcone, not to be confused with the compound chalcone). It is synthesized from ... 4-coumaroyl-CoA and malonyl-CoA by chalcone synthase (CHS), a key enzyme in the phenylpropanoid pathway. ...
Novel action of the chalcone isoliquiritigenin as a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor:...
ISLQ completely abolished the cholera toxin-induced transepithelial Cl(-) secretion in T84 cells and reduced the cholera toxin- ... Isoliquiritigenin (ISLQ) is a plant-derived chalcone that has a wide range of biological activities. The present study thus ... Apical Cl(-) current analysis of T84 cell monolayers indicated that ISLQ blocked mainly the cystic fibrosis transmembrane ... Short-circuit current analysis of human intestinal epithelial (T84) cell monolayers revealed that ISLQ dose-dependently ...
UV-B, UV-A, and blue light signal transduction pathways interact synergistically to regulate chalcone synthase gene expression...
Your Name) has sent you a message from Plant Cell Message Body (Your Name) thought you would like to see the Plant Cell web ... The Plant Cell Dec 1996, 8 (12) 2347-2357; DOI: 10.1105/tpc.8.12.2347 ... The Plant Cell Dec 1996, 8 (12) 2347-2357; DOI: 10.1105/tpc.8.12.2347 ... UV-B, UV-A, and blue light signal transduction pathways interact synergistically to regulate chalcone synthase gene expression ...
Synthesis, Antioxidant and Antimicrobial Activities of a Novel Series of Chalcones, Pyrazolic Chalcones, and Allylic Chalcones
A novel series of pyrazolicchalcones (5a-c) have been synthesized by the reaction of respective chalcones (4a-c) and hydrazine ... A new series of chalcones (4a-c) and allylicchalcones (11a-b) have been prepared by the Claisen-Schmidt condensation. ... Design, Synthesis and Docking Studies of Flavokawain B Type Chalcones and Their Cytotoxic Effects on MCF-7 and MDA-MB-231 Cell ... " Design, Synthesis and Docking Studies of Flavokawain B Type Chalcones and Their Cytotoxic Effects on MCF-7 and MDA-MB-231 Cell ...
Synthesis of Nitrogen Containing Chalcone: A Highly Sensitive and Selective Fluorescent Chemosensor for the Fe 3+ Metal Ion in...
... push-pull effect and a p-conjugated system in conversion efficiency of bis-chalcone compounds in a dye sensitized solar cell. J ... Results show that chalcone act as on-off switching fluorescent chemosensor for selective and sensitive detection iron metal ion ... Asiri, A.M., Al-Amari, M.M. & Khan, S.A. Synthesis of Nitrogen Containing Chalcone: A Highly Sensitive and Selective ... Synthesis of Nitrogen Containing Chalcone: A Highly Sensitive and Selective Fluorescent Chemosensor for the Fe3+ Metal Ion in ...
Molecules | Free Full-Text | Anticarcinogenic Effect of Spices Due to Phenolic and Flavonoid Compounds-In Vitro Evaluation on...
22RV1 and PC3 cells is from the naringenin chalcone contained in black pepper. From the spectrum of compounds assessed, the ... naringenin chalcone contained in black pepper was identified as the most potent inhibitor of the growth of prostate cells. ... The strongest inhibitory effect on prostatic cells was observed after the application of extracts of spices in concentration of ... 4-dihydroxybenzaldehyde and naringenin chalcone, while the most abundant phenolic and flavonoid compounds in caraway seeds are ...
A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway | Cancer Cell International |...
Moreover, the activation of Stat3 had also been abrogated both in Lj-1-60 treated melanoma cells or Fyn knocked down cells. Our ... 83 inhibitors were further detected to explore the effect on melanoma cells growth and discovered a novel chalcone derivative ... Whats more, Lj-1-60 suppressed the proliferation of melanoma in vitro and in vivo through inducing cell cycle arrest and ... We investigated the impacts of Fyn and its inhibitor Lj-1-60 on melanoma through bioinformatics analysis, western blot, cell ...
Structural insights into a novel anticancer sulfonamide chalcone - New Journal of Chemistry (RSC Publishing)
Among the various naturally occurring classes, we can highlight chalcones, sulfonamides and hybrid compounds formed by both. ... In addition, a cytotoxic effect was observed for all strains, which was more pronounced for HCT-116, a colon cancer cell line. ... Structural insights into a novel anticancer sulfonamide chalcone J. M. F. Custodio, L. J. Michelini, M. R. C. de Castro, W. F. ... We show that the BSC compound has a planar conformation in its chalcone portion, which is further corroborated by the low angle ...
Methoxyphenyl chalcone sensitizes aggressive epithelial cancer to cisplatin through apoptosis induction and cancer stem cell...
Methoxyphenyl chalcone sensitizes aggressive epithelial cancer to cisplatin through apoptosis induction and cancer stem cell ... Methoxyphenyl chalcone sensitizes aggressive epithelial cancer to cisplatin through apoptosis induction and cancer stem cell ... Methoxyphenyl chalcone sensitizes aggressive epithelial cancer to cisplatin through apoptosis induction and cancer stem cell ... Methoxyphenyl chalcone sensitizes aggressive epithelial cancer to cisplatin through apoptosis induction and cancer stem cell ...
IJASEAT Investigation Of The Apoptotic Pathway Induced By C3-Pyrazole/Chalcone Linked Beta-Carboline Hybrids Against Human...
Investigation Of The Apoptotic Pathway Induced By C3-Pyrazole/Chalcone Linked Beta-Carboline Hybrids Against Human Breast ... Of The Apoptotic Pathway Induced By C3-Pyrazole/Chalcone Linked Beta-Carboline Hybrids Against Human Breast Cancer Cells Mcf-7 ... In our previous studies C3-Pyrazole/Chalcone Linked Beta-Carboline Hybrids were synthesized and evaluated for their cytotoxic ... and Annexin V-FITC assay revealed that these compounds induced mitochondrial mediated apoptosis in human breast cancer cells ( ...
The chalcone butein from Rhus verniciflua Stokes inhibits clonogenic growth of human breast cancer cells co-cultured with...
... clonogenic growth of the primary breast cancer cells was also significantly reduced or abolished when the tumor cells were co- ... A similar dose of butein had no effect on the clonogenic growth of breast cancer cells cultured in the absence of fibroblasts. ... We first measured the clonogenic growth of small numbers of the UACC-812 human breast cancer cell line co-cultured on ... Because fibroblasts are believed to play an important role in promoting the growth of breast cancer cells, we investigated the ...
A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells |...
... ultimately leading to extreme vacuolization and rupture of the cell. Here we describe a novel chalcone-like molecule, 3-(2-m ... Cells treated with MIPP lose viability within 2-3 days, but their nuclei show no evidence of apoptotic changes. Inhibition of ... U251 glioblastoma cells selected for temozolomide resistance showed sensitivity to MIPP-induced methuosis that was comparable ... to the parental cell line. MIPP might serve as a prototype for new drugs that could be used to induce non-apoptotic death in ...
Effects of PI3K/AKT/MTOR and VEGFR pathway inhibitors on liver cancer stem cells and bioactivities of novel pyrazolic...
... bioactivities of pyrazolic chalcone derivatives on HCC cell lines and their mechanism of action were investigated. Chalcones ... Further investigation of cell cycle progression and cell death mechanisms have revealed that compounds 42 and 52 caused cell ... Newly synthesized pyrazolic chalcone derivatives were tested against different cancer cells, and selection based on the IC50 ... Effects of PI3K/AKT/MTOR and VEGFR pathway inhibitors on liver cancer stem cells and bioactivities of novel pyrazolic chalcone ...
Frontiers | The Woody-Preferential Gene EgMYB88 Regulates the Biosynthesis of Phenylpropanoid-Derived Compounds in Wood | Plant...
2011). Isolation and promoter analysis of a chalcone synthase gene PtrCHS4 from Populus trichocarpa. Plant Cell Rep. 30, 1661- ... the cambial cells divide and differentiate centripetally into xylem cells, characterized by thick secondary cell walls made of ... A) Detail of the cambial region and of the first layers of differentiating xylem cells. (B) Detail of mature xylem cells. ... cell division cycle2; CHS, chalcone synthase; DFR, dihydroflavonol-4-reductase; EAR, Ethylene-responsive element binding factor ...
ApoptosisFlavonoidsNovel chalcone derivativesMoleculesInhibitionFlavonoidDerivativeVitro2017GenesSyntheticInhibitsAnticancerOptimizing chalcone derivativesAssayEnzymesCompoundSynthesis of ChalconesAnalogues2018XanthohumolPetuniaMajor chalconePotentMetabolismSquamous Cell CarcGeneStilbeneBiosynthesisKava extractGastricEpithelialFlavanoneTumor cellsAntiproliferative activityViabilityApoptoticActivityInterestinglyCytotoxicityPolyphenolsMoleculeEndothelialBiologicalExtractProstate cancerFibroblastsSelectivelyCancerPharmacologicalAntimicrobialCyclizationBioactiveMice
- Short term treatments with compound 8 resulted in a dose-dependent decrease of Notch signaling activity, halted cell cycle progression and induced apoptosis, thus affecting leukemia cell growth. (sigmaaldrich.com)
- Treatment with NAC almost completely attenuated chalcone-induced cell inhibition and cell apoptosis in MGC-803 cells, indicating that the apoptotic mechanisms were related to ROS generation. (springer.com)
- Therefore, this chalcone derivative is a new apoptosis inducer for prevention and treatment of gastric cancer. (springer.com)
- Using the primary mouse embryo fibroblasts Bax knockout and wild-type cells as well as a Bax inhibitor peptide derived from the Bax-binding domain of Ku70, we showed that Bax protein was, at least in part, required for the apoptotic effect of flavokawain A. In addition, flavokawain A down-regulates the expression of X-linked inhibitor of apoptosis and survivin. (aacrjournals.org)
- Here, we show that xanthohumol at a concentration of 25 µM induced apoptosis in two HCC cell lines (HepG2 and Huh7). (spandidos-publications.com)
- We found that cell viability of ovarian cancer cells was decreased through apoptosis induction. (elsevier.com)
- In the present investigation studies like flowcytometry of mitochondrial membrane potential (ΔΨm), generation of reactive oxygen species (ROS) and Annexin V-FITC assay revealed that these compounds induced mitochondrial mediated apoptosis in human breast cancer cells (MCF-7). (iraj.in)
- Cancer cells typically harbor mutations in tumor suppressor genes that control programmed cell death, rendering them relatively insensitive to apoptosis. (biomedcentral.com)
- However, the potential for exploiting this non-conventional cell death pathway to kill cancer cells that are refractory to apoptosis will depend on the identification of molecules with drug-like properties that can induce methuosis. (biomedcentral.com)
- First, the chalcone analogues induce the unfolded protein response followed by apoptosis. (stanford.edu)
- Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate. (stanford.edu)
- Xanthoangelol, a major chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma and leukemia cells. (webmd.com)
- A compound from Allium hirtifolium could inhibit growth of MCF-7 and MDA-MB-231 cells through cell cycle arrest and apoptosis induction. (greenmedinfo.com)
- Indeed, metformin blocks cell growth but can also induce apoptosis in some cancer cell models. (biomedsearch.com)
- They showed that the treatment of breast cancer cells with metformin alone does not induce apoptosis but arrests cells in G 0 /G 1 . (biomedsearch.com)
- We evaluated the effect of DPP-23 on proliferation, cell cycle, and apoptosis in various tumor cells. (aacrjournals.org)
- At a molecular level, DPP-23 targeted the unfolded protein response (UPR) in the endoplasmic reticulum (ER) through the production of reactive oxygen species (ROS) in cancer cells, but not in normal cells, resulting in selective killing of tumor cells via caspase-dependent apoptosis. (aacrjournals.org)
- Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. (semanticscholar.org)
- These findings suggest that C10 treatment induces the PKCδ/JNK pathway, thereby activating Caspase-3 and inducing the cleavage of PARP and gasdermin E to execute apoptosis and cell-lytic pyroptosis in prostate cancer cells. (aging-us.com)
- The effects of hyperoside on apoptosis and the expression of Fas/FasL and survivin in SW579 human thyroid squamous cell carcinoma cell line. (abcam.com)
- MicroRNA-182 downregulates Wnt/ß-catenin signaling, inhibits proliferation, and promotes apoptosis in human osteosarcoma cells by targeting HOXA9. (abcam.com)
- A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells. (abcam.com)
- Survivin, a key player in cancer progression, increases in obesity and protects adipose tissue stem cells from apoptosis. (abcam.com)
- Survivin downregulation using siRNA nanoliposomes inhibits cell proliferation and promotes the apoptosis of MHCC-97H hepatic cancer cells: An in vitro and in vivo study. (abcam.com)
- miR-143 and miR-145 disrupt the cervical epithelial barrier through dysregulation of cell adhesion, apoptosis and proliferation. (abcam.com)
- We examined the cell proliferation effect and mechanism of C. concinna -derived cryptocaryone (CPC) on oral cancer cells in terms of cell viability, apoptosis, reactive oxygen species (ROS), mitochondrial depolarization, and DNA damage. (biomedcentral.com)
- The CPC-induced dose-responsive apoptosis effects on Ca9-22 cells were confirmed by flow cytometry-based sub-G1 accumulation, annexin V staining, and pancaspase analyses. (biomedcentral.com)
- CPC-induced cell responses in terms of cell viability, apoptosis, oxidative stress, and DNA damage were rescued by N-acetylcysteine pretreatment, suggesting that oxidative stress plays an important role in CPC-induced death of oral cancer cells. (biomedcentral.com)
- These compounds have been shown to exert their anticancer effects via a variety of mechanisms including cell cycle arrest, apoptosis induction, inhibition of cell proliferation and angiogenesis, modulating protein expression of various cell signalling pathways including the PI3K/Akt/m-TOR pathway, etc [7- (termedia.pl)
- Induction of Apoptosis in Human Breast Adenocarcinoma MCF-7 Cells by Prodelphinidin B-2 3,3'-di-O-gallate from Myrica Rubra Via Fas-mediated Pathway The Journal of Pharmacy and Pharmacology. (jove.com)
- We elucidated the underlying mechanism by which Lico B can induce apoptosis in oral squamous cell carcinoma (OSCC). (spandidos-publications.com)
- Licochalcone B (Lico B), a chalconoid presents in the root of Glycyrrhiza species, not only inhibit cell proliferation, but also to induce cell cycle arrest and apoptosis ( 10 ). (spandidos-publications.com)
- Apoptosis (programmed cell death), triggers an extrinsic (death receptor-mediated signaling) or an intrinsic (mitochondria-mediated signaling) pathway to activate caspase-3, leading to morphological alterations (e.g. (spandidos-publications.com)
- Distribution of Flavonoids and Cyclohexenyl Chalcone Derivatives in Conventional Propagated and In Vitro-Derived Field-Grown Boesenbergia rotunda (L.) Mansf. (hindawi.com)
- The distribution patterns of flavonoids and cyclohexenyl chalcone derivatives in conventional propagated (CP) and in vitro -derived (CPA) field-grown plants of an important medicinal ginger, Boesenbergia rotunda , are described. (hindawi.com)
- Anjari S.S. (2010), "Evaluation of Antioxidant Activity of Chalcones and Flavonoids" International Journal of ChemTech Research, (2), 1080-1089. (pharmatutor.org)
- Chalcones are the biogenetic precursors of all known flavonoids, which play an essential role in various metabolic processes in photosynthesizing organisms. (biomedcentral.com)
- Therefore, determination of the ability of whole cells of selected cyanobacteria to carry out biocatalytic transformations of chalcone, the biogenetic precursor of all known flavonoids, was the aim of our study. (biomedcentral.com)
- Extraction from plants is classic and still the most popular method of obtaining the majority of flavonoids, including chalcones. (biomedcentral.com)
Novel chalcone derivatives3
- Cytotoxicity of selected novel chalcone derivatives on human breast, lung and hepatic carcinoma cell lines. (thefreedictionary.com)
- These data demonstrate the potential of these novel chalcone derivatives as treatments for triple negative breast cancer, though further work evaluating their efficacy in vivo is needed. (stanford.edu)
- Novel Chalcone Derivatives as Potent Nrf2 Activators in Mice and Human Lung Epithelial Cells," Journal of medicinal Chemistry, 54(12), 4147-4159 (May 3, 2011). (freepatentsonline.com)
- Chalcones are a group of molecules with a broad spectrum of biological activities, being especially appealing for their antiproliferative effects on several cancer cell lines. (springer.com)
- Here, by functional and biological analysis of the most representative molecules of an in house library of natural products, we have designed and synthetized the chalcone-derivative 8 possessing Notch inhibitory activity at low micro molar concentration in T-ALL cell lines. (sigmaaldrich.com)
- 4-coumaroyl-CoA and three units of malonyl-CoA are converted into three molecules of carbon dioxide, four molecules of coenzyme A and one unit of naringenin chalcone. (wikipedia.org)
- In our previous studies C3-Pyrazole/Chalcone Linked Beta-Carboline Hybrids were synthesized and evaluated for their cytotoxic activity in a panel of five human cancer cell lines and the new molecules like 7d and 8d were considered as potential leads. (iraj.in)
- More recently, this therapeutic efficacy has been attributed to the bioactive molecules that these cells secrete (secretome), now being referred as medicinal signaling cells. (stanford.edu)
- Here, three novel synthetic analogues of chalcones, plant-based molecules that have demonstrated potency against a wide variety of cancers, were investigated as potential therapeutics for triple negative breast cancer. (stanford.edu)
- The cytotoxicity profiles of stilbene-fused chalcones in cancer cells imply that these molecules mostly mimic the simple chalcone structures. (eurekaselect.com)
- Additionally, aromatase inhibition assays showed that stilbene-fused chalcones again do mimic the simple-chalcones but not simple-stilbenes and anti-angiogenic profiles of the tested molecules seem to be not related with stilbene fragments. (eurekaselect.com)
- Chern, C.Y. (2013), "Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model", Molecules, (18), 2052-2060. (pharmatutor.org)
- Tran, T.D. (2016), "Synthesis and Selective Cytotoxic Activities on Rhabdomyosarcoma and Noncancerous Cells of Some Heterocyclic Chalcones", Molecules, (21), 1-10. (pharmatutor.org)
- Herein, we report the synthesis, structures, and characterization of a series of five chalcone derivatives, obtained by carefully modifying the structure with various para and meta substitutents, expecting new molecules with high second-order optical nonlinearities. (scirp.org)
- Chalcone-benzoxaborole hybrid molecules as potent antitrypanosomal agents. (elsevier.com)
- Chalcones represent an important group of the polyphenolic family, which includes a large number of naturally occurring molecules. (biomedcentral.com)
- Finally, the anticarcinogenic effect of flavokawain A was evident in its inhibitory growth of bladder tumor cells in a nude mice model (57% of inhibition) and in soft agar. (aacrjournals.org)
- Natural chalcones as well as their synthetic derivatives have shown biological activity in a number of areas including the inhibition of cancer cell growth. (eurekaselect.com)
- Objective: To synthesize a library of chalcone derivatives, including novel structures, and determiner the inhibition of ovarian cancer cell growth and Structure-activity-relationships. (eurekaselect.com)
- Electron-withdrawing modifications to the B ring did not show inhibition of cell growth. (eurekaselect.com)
- Inhibition of caspase activity does not protect the cells, consistent with a non-apoptotic death mechanism. (biomedcentral.com)
- Inhibition of IL-8 signaling resulted in reduction in both LCSC ratio and sphere formation capacity of HCC cells, which could be indicating the role of IL-8 signaling in the conservation of stemness features of LCSCs. (bilkent.edu.tr)
- Among those, two derivatives also showed inhibition of p38 signaling in human breast cancer cells. (dissertations.se)
- Method: For this purpose, eleven previously synthesized simple-stilbene, chalcone, flavanone derivatives and 31 novel stilbene-fused chalcones and stilbene-fused flavanones were tested for their aromatase inhibition, antiangiogenic and anti-proliferative properties in cancer (PC3, MCF-7) and healthy (HUVEC) cell lines. (eurekaselect.com)
- Inhibition of gastric H+, K(+)-ATPase by chalcone derivatives, xanthoangelol and 4-hydroxyderricin, from Angelica keiskei Koidzumi. (webmd.com)
- 4 The increase of glycolysis induced by metformin is somehow inconsistent with the observed inhibition of proliferation, since cancer cells use preferentially glycolysis to grow faster. (biomedsearch.com)
- In cancer cells, the increase of glycolysis induced by metformin is associated with a strong inhibition of the mTOR pathway via the AMPK. (biomedsearch.com)
- Data are expressed as mean % inhibition of cell proliferation ± SEM (n=4). (dmu.ac.uk)
- Aslan, G.(2017), "Design of potent fluoro-substituted chalcones as antimicrobial agents", Journal Of Enzyme Inhibition And Medicinal Chemistry, 32(1), 490-495. (pharmatutor.org)
- The monocarboxylate transporter 1 (MCT1) is a key element in tumor cell metabolism and inhibition of MCT1 with AZD3965 is undergoing clinical trials. (imperial.ac.uk)
- Butein efficiently inhibited the mTOR/p70S6K translational inhibition machinery and decreased the production of VEGF in B16F10 cells. (biomedcentral.com)
- In this article, we propose a novel strategy to obtain parthenocarpic tomatoes by down-regulation of the flavonoid biosynthesis pathway using RNA interference (RNAi)-mediated suppression of chalcone synthase (CHS), the first gene in the flavonoid pathway. (plantphysiol.org)
- Isoliquiritigenin (ISL), a flavonoid chalcone that is present in licorice, shallot, and bean sprouts, has antitumorigenic activities in prostate tumor cells. (greenmedinfo.com)
- Finally, we generated transgenic spruce cell lines overexpressing four of the Norway spruce At TT2 homologs and observed differential regulation of genes in the flavonoid pathway and flavonoid contents. (frontiersin.org)
- Chalcones are a valuable molecule of medicinal importance due to presence of reactive ketoethylenic group -CO-CH=CH-, belonging to the flavonoid family. (pharmatutor.org)
- Chalcones considered as obligate intermediated in flavonoid biosynthesis but they do not accumulate to appreciable degree in most plants [ 3 ]. (biomedcentral.com)
- Results: We show that FKA inhibits the growth and motility of multiple OS cell lines in vitro. (aacrjournals.org)
- 2004) Resveratrol inhibits the release of mediators from bone marrow-derived mouse mast cells in vitro. (scirp.org)
- Combined treatment reduced in vitro migration in a simulated wounding model while also promoting cell cycle arrest at the G2/M phase. (stanford.edu)
- Some studies have been carried out in human breast cancer cells, small airway cells, and endothelial cells in vitro ( 18 - 22 ). (aacrjournals.org)
- DPP-23 effectively inhibited the growth of cancer cells in vitro and in vivo (xenografts in Balb/c nude mice). (aacrjournals.org)
- MTT cell viability assays were used to evaluate the antitumor effects of butein in vitro. (biomedcentral.com)
- In vitro, butein was found to inhibit the migration of B16F10 cells in a concentration-dependent manner using transwell and scratch assays. (biomedcentral.com)
- The search for consonance between plant secondary metabolism unique features and various in vitro culture systems, including cell, tissue, organ, and engineered cultures, as well as heterologous expression in microbial platforms, is discussed. (dmu.ac.uk)
- Quantitative RT-PCR (qRT-PCR) and western blot analysis showed that 1 and 1d significantly improve the expression of nuclear factor erythroid 2 p45-related factor 2 (Nrf2)-dependent antioxidant genes g-Glutamylcysteine Ligase Catalytic Subunit ( GCLC ) and heme oxygenase-1 ( HO-1 ) and their corresponding proteins (γ-glutamyl cysteine synthase (γ-GCS) and HO-1) in PC12 cells. (mdpi.com)
- Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. (thefreedictionary.com)
- Genome-wide analysis of the chalcone synthase superfamily genes of Physcomitrella patens Koduri, P. (deepdyve.com)
- The highly specific transcriptome survey of the stylar canal cells identified novel genes which have not been previously associated with self-pollen rejection in citrus and in other plant species. (biomedcentral.com)
- Publications] S.Fukada-Tanaka: 'Identification of new chalcone synthase genes for flowerpigmentation in the Japanese and common morning glories'Plant Cell Physiol. (nii.ac.jp)
- The organization and the structure of the genes encoding phenylalanine ammonia-lyase (PAL) and chalcone synthase (CHS) were determined and the effects of elicitor and suppressor produced by a pea pathogen, Mycosphaerella pinodes, were examined by transforming a chimeric DNA containing the PAL- and CHS-promoter fragments connected to a reporter gene into tobacco or pea plant with particle gun, Agrobacterium-mediated transformation, or electroporation. (nii.ac.jp)
- RNAi is a valuable research tool, both in cell culture and in living organisms , because synthetic dsRNA introduced into cells can selectively and robustly induce suppression of specific genes of interest. (wikipedia.org)
- The initiating dsRNA can also be endogenous (originating in the cell), as in pre-microRNAs expressed from RNA-coding genes in the genome. (wikipedia.org)
- We propose that leaf expansion in Arabidopsis involves at least two independent developmental processes: width development and length development, with the ANGUSTIFOLIA and ROTUNDIFOLIA3 genes playing different polarity-specific roles in cell elongation. (biologists.org)
- Batovska D, Parushev S, Slavova A, Bankova V, Tsvetkova I, Ninova M, Najdenski H (2007) Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans. (springer.com)
- Synthetic chromone precursors, i.e. chalcones, and related dienones were evaluated as antiproliferative agents that interfere with the tubulin-microtubule equilibrium, crucial for cellular mitosis. (dissertations.se)
- For example, cyclohexenyl chalcone derivatives (CCDs), such as panduratin A and hydroxypanduratin A, exhibit anti-inflammatory activity that inhibits the production of both nitric oxide and prostaglandin through the suppression of NF- κβ activation [ 6 ]. (hindawi.com)
- Clemastine Fumarate inhibits histamine induced rise in [Ca 2+ ] i in HL-60 cells with an IC50 of 3 nM as compared with that of chlorpheniramine or diphenhydramine with IC50 values of 20 nM and 100 nM, respectively. (selleckchem.com)
- Clemastine Fumarate potently inhibits the HERG K + channel in a concentration-dependent manner in HEK 293 cells stably expressing HERG channels with an IC50 of 12 nM, which can be attenuated by the Y652A or F656A mutation of HERG. (selleckchem.com)
- Consequently, BSC was experimentally evaluated against three cancer cell lines, and was shown to hold potent anticancer activity. (rsc.org)
- This thesis comprises the design and synthesis of chalcone and chromone derivatives and their use in various biological applications, particularly as anticancer agents (targeting proteins associated with cancer pathogenesis) and as potential fluorophores for live-cell imaging. (dissertations.se)
- Ruparelia, K. C. As part of a programme to develop anticancer prodrugs which are activated by cytochrome P450 (CYP)1B1, a library of 4,6-diaryl-2-pyridones was synthesised in yields of 6-60% from the corresponding chalcones. (dmu.ac.uk)
- This review is focused about different methods of synthesis and versatile biological activity of chalcones including antimicrobial, anticancer, antioxidant, antimalarial, antituberculosis etc. (pharmatutor.org)
- The anticancer activity of 5h was better than that of 5-FU at high concentrations cell-selectively against C6 cells. (tubitak.gov.tr)
Optimizing chalcone derivatives1
- Zuurbier, K.W.M. , Fung, S.-Y. , Scheffer, J.J.C. & Verpoorte, R. ( 1993 ) Assay of chalcone synthase activity by high-performance liquid chromatography. (wiley.com)
- We found that CPC dose-responsively reduced cell viability of two types of oral cancer cells (Ca9-22 and CAL 27) in MTS assay. (biomedcentral.com)
- Using MTT assay, a set of eleven different human and murine cell lines (like MCF7, N2A , NI[H. (thefreedictionary.com)
- Schröder, J. & Schröder, G. ( 1990 ) Stilbene and chalcone synthase: related enzymes with key functions in plant specific pathways. (wiley.com)
- Suh, Dae-Yeon 2009-10-31 00:00:00 Enzymes of the chalcone synthase (CHS) superfamily catalyze the production of a variety of secondary metabolites in bacteria, fungi and plants. (deepdyve.com)
- Induction of phase 2 enzymes and elevations of glutathione are major and sufficient strategies for protecting mammals and their cells against the toxic and carcinogenic effects of electrophiles and reactive forms of oxygen. (semanticscholar.org)
- Toward this end, we now describe a chalcone-related compound that can induce cell death with the hallmarks of methuosis in both temozolomide-resistant and non-resistant glioblastoma cells. (biomedcentral.com)
- In LAD2 mast cells, both resveratrol and tranilast inhibited degranulation induced by the mast cell activators substance P, IgE/anti-IgE, and compound 48/80. (scirp.org)
- Preliminary results show the compound in beer seems to have a protective effect on neurons that are the signalling cells in the brain. (emaxhealth.com)
- NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation. (adooq.com)
Synthesis of Chalcones1
- And third, treatment with the chalcone analogues causes disruption of the cell cycle by interfering with microtubule structure and by inducing G1 phase arrest. (stanford.edu)
- Different effects of two cyclic chalcone analogues on redox status of Jurkat T cells. (semanticscholar.org)
- Amjad, M.W.B. (2013), "Synthesis and evaluation of chalcone analogues based pyrimidines as angiotensinconverting enzyme inhibitors", Pakistan Journal of Biological Science, 16(21), 1368-1372. (pharmatutor.org)
- Xanthohumol, the major prenylated chalcone found in hops, is well known to exert anti-cancer effects, but information regarding the impact on hepatocellular carcinoma (HCC) cells and potential adverse effects on non-tumorous hepatocytes is limited. (spandidos-publications.com)
- In summary, our data showed that xanthohumol can ameliorate different pro-tumorigenic mechanisms known to promote HCC progression, indicating its potential as promising therapeutic agent that selectively affects cancer cells. (spandidos-publications.com)
- Prenylated chalcone xanthohumol assoc. (ugent.be)
- Wyns C, Van Steendam K, Vanhoecke B, Deforce D, Bracke M, Heyerick A. Prenylated chalcone xanthohumol associates with histones in breast cancer cells: a novel target identified by a monoclonal antibody. (ugent.be)
- 9 Xanthohumol is the most abundant prenylated chalcone in hops extract. (naturalmedicinejournal.com)
- RNA-mediated RNA degradation and chalcone synthase A silencing in petunia. (nih.gov)
- Transgenic Petunia plants with a chsA coding sequence under the control of a 35S promoter sometimes lose endogene and transgene chalcone synthase activity and purple flower pigment through posttranscriptional chsA RNA degradation. (nih.gov)
- 1991 ) Sugar-dependent expression of the CHS-A gene for chalcone synthase from petunia in transgenic Arabidopsis . (biologists.org)
- 1 We and others have shown that metformin targets cancer cell metabolism by inhibiting mitochondrial complex 1 activity. (biomedsearch.com)
- OH), all of which are produced ubiquitously in most cells as byproducts of cellular aerobic metabolism. (aacrjournals.org)
- Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. (abcam.com)
- Fett-Neto, A.G. Plant secondary metabolism evolved in the context of highly organized and differentiated cells and tissues, featuring massive chemical complexity operating under tight environmental, developmental and genetic control. (dmu.ac.uk)
Squamous Cell Carc3
- Radiosensitization of Head and Neck Squamous Cell Carcinoma (HNSCC) by a Podophyllotoxin. (stanford.edu)
- Synchronous Primary Pancreatic Ductal Carcinoma and Colonic Adenocarcinoma Present in a Patient With History of Skin Squamous Cell Carcinoma. (amedeo.com)
- Oral squamous cell carcinoma (OSCC), accounting for over 90% of head and neck cancers, is the most common malignancy of oral cavity cancers, with more than half a million new patients diagnosed annually, and metastasis to lymph node frequently takes place ( 1 - 3 ). (spandidos-publications.com)
- UV-B, UV-A, and blue light signal transduction pathways interact synergistically to regulate chalcone synthase gene expression in Arabidopsis. (plantcell.org)
- Here, we provide evidence that several distinct "inductive" and "synergistic" UV/blue phototransduction pathways regulate chalcone synthase (CHS) gene transcription and transcript accumulation in Arabidopsis leaf tissue. (plantcell.org)
- Among them, a novel F-box gene showed a drastic up-regulation both in laser microdissected stylar canal cells and in self-pollinated whole styles with stigmas of 'Comune' in concomitance with the arrest of pollen tube growth. (biomedcentral.com)
- Cytological studies showed that plants with Lux or GUS gene connected to 35S promoter as a control exhibited the distinctive GUS atibity in the cells possibly carrying the chimeric DNA, however those with PAL promoter did not exhibit GUS or Lux activities even by the treatment with fungal elicitor. (nii.ac.jp)
- RNAi may be used for large-scale screens that systematically shut down each gene in the cell, which can help to identify the components necessary for a particular cellular process or an event such as cell division . (wikipedia.org)
- At the cellular level in the angustifolia mutant it was found that the cells were smaller in the leaf-width direction and larger in the leaf-thickness direction than in wild type, revealing the function of the ANGUSTIFOLIA gene, which is to control leaf morphology by regulating polarity-specific cell elongation. (biologists.org)
- 1995 ) The DIMINUTO gene of Arabidopsis is involved in regulating cell elongation. (biologists.org)
- Short-circuit current analysis of human intestinal epithelial (T84) cell monolayers revealed that ISLQ dose-dependently inhibited cAMP-activated Cl(-) secretion with an IC(50) of approximately 20 µM. (sigmaaldrich.com)
- The mechanisms behind the acquired resistance to Sorafenib were described as activation of compensatory pathways such as PI3K/Akt/mTOR, JAK-STAT, epithelial to mesenchymal transition (EMT), microenvironment and presence of cancer stem cells. (bilkent.edu.tr)
- Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells," The Journal of Immunology , vol. 162, no. 5, pp. 2477-2487, 1999. (hindawi.com)
- Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma," Nature Medicine , vol. 8, no. 8, pp. 885-889, 2002. (hindawi.com)
- EPCR expression is up-regulated both at the mRNA and protein levels in invasive prostate DU-145 and PC-3 cells in comparison to normal prostate epithelial cells (PrEC) and less-invasive LNCaP cells. (springermedizin.de)
- These challenges have stimulated interest in identifying alternative cell death pathways that might be used to kill tumor cells that have ceased to respond to drugs that depend on induction of apoptotic mechanisms. (biomedcentral.com)
- The selective killing of tumor cells is an important strategy for cancer therapeutics. (aacrjournals.org)
- The primary object of the present study was to develop a novel antitumor agent that is safe for normal cells and exerts the preferential killing of tumor cells. (aacrjournals.org)
- We also conducted an experimental analysis of the metastatic potential of tumor cells injected into the tail vein of C57BL/6 mice. (biomedcentral.com)
- The rechallenge with syngeneic related ( N2a ) or unrelated (H6) tumor cells was performed in mice surviving initial N2a tumor implantation after receiving prime-boost vaccination with multimodal CV-M002. (thefreedictionary.com)
- We have evaluated the antiproliferative activity of ( E )-3-(3,5-difluorophenyl)-1-(2,4,6-trimethoxyphenyl)- prop-2-en-1-one (chalcone 5 ) against MGC-803 cells. (springer.com)
- Antiproliferative activity of chalcones with basic functionalities," Bioorganic Y& Medicinal Chemistry, 15(22), 7021-7034 (Sep. (freepatentsonline.com)
- For this reason, we synthesized 23 chalcones with good to excellent yields and assessed their effect on the viability of the SH-SY5Y neuroblastoma cell line and on primary human fibroblasts. (springer.com)
- ISLQ did not affect intracellular cAMP levels or cell viability. (sigmaaldrich.com)
- Cells treated with MIPP lose viability within 2-3 days, but their nuclei show no evidence of apoptotic changes. (biomedcentral.com)
- We first demonstrated the effect of butein on cell viability at non-cytotoxic concentrations (1, 3, and 10 μM). (biomedcentral.com)
- We have identified flavokawain A, B, and C but not the major kavalactone, kawain, in kava extracts as causing strong antiproliferative and apoptotic effect in human bladder cancer cells. (aacrjournals.org)
- Methuosis is a unique form of non-apoptotic cell death triggered by alterations in the trafficking of clathrin-independent endosomes, ultimately leading to extreme vacuolization and rupture of the cell. (biomedcentral.com)
- We have shown that this form of cell death is distinct from other kinds of non-apoptotic death noted above [ 16 ]. (biomedcentral.com)
- These studies lend credence to the idea that methuosis may represent a non-apoptotic cell death mechanism of some general importance. (biomedcentral.com)
- Mammary cancer chemoprevention by BITC is associated with apoptotic cell death but the underlying mechanism is not fully understood. (stanford.edu)
- As can be expected from the above results, the apoptotic protease activating factor-1 (Apaf-1) and survivin were oppositely expressed in favor of apoptotic cell death. (spandidos-publications.com)
- Therefore, it is suggested that Lico B is a promising drug for the treatment of human oral cancer via the induction of apoptotic cell death. (spandidos-publications.com)
- Avila HP, Smania EDA, Delle Monache F, Junior AS (2008) Structure-activity relationship of antibacterial chalcones. (springer.com)
- Barua N, Sarmah P, Hussain I, Deka RC, Buragohain AK (2012) DFT-based QSAR models to predict the antimycobacterial activity of chalcones. (springer.com)
- Structure-activity relationships were afforded for the chalcone scaffold. (sigmaaldrich.com)
- The methoxy-substituted aurones and the unsubstituted aurone also showed low micromolar (IC 50 ) activity against MRC-5 non-tumoral lung cells and MDA-MB-231 breast cancer cells, suggesting non-specific toxicity. (rsc.org)
- Biological evaluation of these β-phenylacrylophenone derivatives in CA-OV3 cells showed interesting antiproliferative activities providing initial structure - activity information. (eurekaselect.com)
- Next, chalcone derivatives were synthesized and assayed for their antimicrobial activity against several bacterial strains in combination with penicillin antibiotics. (thefreedictionary.com)
- Histochemical staining for [beta]-glucuronidase activity showed that the PAL1 promoter is preferentially activated in photosynthetically active cells, paralleling anthocyanin accumulation. (plantphysiol.org)
- Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei KOIDZUMI. (webmd.com)
- We here highlight the unique relationship between pharmacokinetics and anti-asthmatic activity of chalcone 4, a CXCL12 neutraligand. (ersjournals.com)
- On the basis of quantitative structure-activity relationship, we synthesized a novel polyphenol conjugate (E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl)prop-2-en-1-one (DPP-23). (aacrjournals.org)
- These reactive α,β-unsatutated keto function in chalcones are responsible for their biological activity. (pharmatutor.org)
- Pinaceae), Rhamnus purshiana D.C. (Rhamnaceae) and Hibiscus sabdariffa L. (Malvaceae), which have been used as folk medicine in Canada, were evaluated for their anti-hepatoma activity on five human liver-cancer cell lines, i.e. (jove.com)
- r 2 = 0.836) showed that lipophilicity (CLogP) is the most important factor to increase their cytotoxicity on the cancer cell line. (springer.com)
- The selective generation of ROS in cancer cells could be an attractive strategy for the selective killing of cancer cells, while maintaining negligible cytotoxicity to normal cells. (aacrjournals.org)
- Here we describe a novel chalcone-like molecule, 3-(2- m ethyl-1H- i ndol-3-yl)-1-(4- p yridinyl)-2- p ropen-1-one (MIPP) that induces cell death with the hallmarks of methuosis. (biomedcentral.com)
- A previously reported fluorescent probe (CDg4) was shown to selectively bind glycogen in mouse embryonic stem cells, however the molecule was not evaluated in cancer cells. (imperial.ac.uk)
- A small molecule targeting cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. (elsevier.com)
- Method: Chalcones were synthesised via the Claisen-Schmidt condensation and verified via nuclear magnetic resonance (NMR) and mass spectrometry (MS). Primary Human umbilical vein endothelial cells (HUVECs) were cultured according to manufactures protocol. (dmu.ac.uk)
- Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells. (semanticscholar.org)
- Also expressed in lymphocytes, fibroblasts and endothelial cells. (abcam.com)
- Flavokawain A results in a significant loss of mitochondrial membrane potential and release of cytochrome c into the cytosol in an invasive bladder cancer cell line T24. (aacrjournals.org)
- 11 , 12 ] reported that panduratin D was cytotoxic against pancreatic cancer cells. (hindawi.com)
- In addition, a cytotoxic effect was observed for all strains, which was more pronounced for HCT-116, a colon cancer cell line. (rsc.org)
- Recent evidence proves ovarian cancer stem cells as the source of resistance. (elsevier.com)
- Therefore, treatment strategy to target both cancer stem cells and normal stem cells is essential. (elsevier.com)
- We found that methoxyphenyl chalcone was effective to eliminate ovarian cancer cells when given either as monotherapy or in combination with cisplatin. (elsevier.com)
- Liver cancer stem cells originate from damaged and transformed hepatic progenitor cells (HPCs) which are found responsible for chemo-resistance, tumor relapse, and metastasis. (bilkent.edu.tr)
- Another topic in this thesis focuses on the potential of VEGFR2 TKIs and quinoids to inhibit both liver cancer cells and liver cancer stem cells. (bilkent.edu.tr)
- In recent years it has also been shown that antiangiogenic agents are increasing cancer stem cell population via generation of tumor hypoxia. (bilkent.edu.tr)
- Using human plasma samples, tumor tissue, cancer cell lines, and genetically engineered mouse models, the origins of these proteins are being investigated. (stanford.edu)
- This laboratory is also focused on the identification of proteins with expression restricted to the surface of cancer cells which can be used as novel targets for molecular imaging technologies. (stanford.edu)
- Buckwheat sprouts have an anti-inflammatory effect in lipopolysaccharide-activated human colon cancer cells and mice. (greenmedinfo.com)
- 2 , 3 This energetic stress leads to a decrease of intracellular ATP concentration, and cancer cells will increase their rate of glycolysis. (biomedsearch.com)
- 2 This compensatory response is not sufficient to restore ATP levels, but is adequate to maintain viable cells in most of the cancer cells. (biomedsearch.com)
- A number of these derivatives showed promising antiproliferative activities in human breast cancer cell lines which express CYP1B1 and CYP1A1, while showing little toxicity towards a non-tumour breast cell line with no CYP expression. (dmu.ac.uk)
- DPP-23 represents a promising novel therapeutic agent for the selective production of ROS in cancer cells. (aacrjournals.org)
- This study supports a molecular basis for the development of agents that stimulate the UPR via the production of ROS in cancer cells and for further evaluation in early-phase clinical trials. (aacrjournals.org)
- Background: Glycogen is a multibranched polysaccharide of glucose produced by cells to store energy and plays a key role in cancer. (imperial.ac.uk)
- Redox-related Molecular Mechanism of Sensitizing Colon Cancer Cells to Camptothecin Analog SN38. (amedeo.com)
- MK615 Suppresses Hypoxia Tolerance by Up-regulation of E-cadherin in Colorectal Cancer Cells With Mutant KRAS. (amedeo.com)
- Clinical Implications of Cancer Stem Cell Markers and ABC Transporters as a Predictor of Prognosis in Colorectal Cancer Patients. (amedeo.com)
- Sabutoclax, pan-active BCL-2 protein family antagonist, overcomes drug resistance and eliminates cancer stem cells in breast cancer. (abcam.com)
- For oral cancer Ca9-22 cells, CPC also induced oxidative stress responses in terms of ROS generation and mitochondrial depolarization. (biomedcentral.com)
- Moreover, the cell killing mechanism of cryptocaryone in cancer remains unclear. (biomedcentral.com)
- Chalcones are absorbed in the daily diet and appear to be promising cancer chemopreventive agents. (biomedcentral.com)
- The present paper is primarily concerned with chalcone derivatives found in edible plants, fruits, and vegetables and with their positive effects in cancer chemoprevention and carcinogenesis. (biomedcentral.com)
- Cancer, which accounts for around 7.5 million deaths and 12.6 million cases of the disease annually, is characterized by abnormal cell growth and uncontrolled cell division. (termedia.pl)
- He found that cancer cells cannot survive in the presence of high levels of oxygen. (areawidenews.com)
- Based on the neuroprotective properties of 2-pyrazoline derivatives, in the current work, 1-(phenyl/4-substituted phenyl)-3-(2-furanyl/thienyl)-5-aryl-2-pyrazolines ( 3a ⁻ i , 4a ⁻ i ) were synthesized via the cyclization of the chalcones ( 1 , 2 ) with suitable phenylhydrazine hydrochloride derivatives. (nih.gov)