A disaccharide consisting of two glucose units in beta (1-4) glycosidic linkage. Obtained from the partial hydrolysis of cellulose.
Reversibly catalyze the oxidation of a hydroxyl group of carbohydrates to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2.; and 1.1.99.
A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.
An exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of GLUCOSE.
An endocellulase with specificity for the hydrolysis of 1,4-beta-glucosidic linkages in CELLULOSE, lichenin, and cereal beta-glucans.
Dextrins are a group of partially degraded and digestible starches, formed through the hydrolysis of starch by heat, acids, or enzymes, consisting of shorter chain polymers of D-glucose units linked mainly by α-(1→4) and α-(1→6) glycosidic bonds.
Oligosaccharides containing two monosaccharide units linked by a glycosidic bond.
A genus of fungi in the family Corticiaceae, order Stereales, that degrades lignin. The white-rot fungus Phanerochaete chrysosporium is a frequently used species in research.
An exocellulase with specificity for the hydrolysis of 1,4-beta-glucosidic linkages of 1,4-beta-D-glucans resulting in successive removal of GLUCOSE units.
An exocellulase with specificity for the hydrolysis of 1,4-beta-D-glucosidic linkages in CELLULOSE and cellotetraose. It catalyzes the hydrolysis of terminal non-reducing ends of beta-D-glucosides with release of CELLOBIOSE.
A mitosporic Ophiostomataceae fungal genus, whose species Sporothrix schenckii is a well-known animal pathogen. The conidia of this soil fungus may be inhaled causing a primary lung infection, or may infect independently via skin punctures.
Tetroses are uncommon sugars (monosaccharides) with four carbon atoms, having an aldehyde functional group at the first carbon atom, and forming ring structures in their cyclic forms, primarily found in complex carbohydrates and certain natural products.
A genus of gram-positive bacteria in the family Lachnospiraceae that inhabits the RUMEN; LARGE INTESTINE; and CECUM of MAMMALS.
A phylum of fungi that produce their sexual spores (basidiospores) on the outside of the basidium. It includes forms commonly known as mushrooms, boletes, puffballs, earthstars, stinkhorns, bird's-nest fungi, jelly fungi, bracket or shelf fungi, and rust and smut fungi.
A genus of motile or nonmotile gram-positive bacteria of the family Clostridiaceae. Many species have been identified with some being pathogenic. They occur in water, soil, and in the intestinal tract of humans and lower animals.
Enzymes that hydrolyze O-glucosyl-compounds. (Enzyme Nomenclature, 1992) EC 3.2.1.-.
A group of anaerobic, rod-shaped bacteria that show up as pink (negative) when treated by the Gram-staining method.
Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.
A family of bacteria found in the mouth and intestinal and respiratory tracts of man and other animals as well as in the human female urogenital tract. Its organisms are also found in soil and on cereal grains.
A family of glycosidases that hydrolyse crystalline CELLULOSE into soluble sugar molecules. Within this family there are a variety of enzyme subtypes with differing substrate specificities that must work together to bring about complete cellulose hydrolysis. They are found in structures called CELLULOSOMES.
A mitosporic fungal genus frequently found in soil and on wood. It is sometimes used for controlling pathogenic fungi. Its teleomorph is HYPOCREA.
A species of gram-positive, thermophilic, cellulolytic bacteria in the family Clostridaceae. It degrades and ferments CELLOBIOSE and CELLULOSE to ETHANOL in the CELLULOSOME.
Glucosides are glycosides that contain glucose as the sugar component, often forming part of the plant's defense mechanism and can have various pharmacological effects when extracted and used medically.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Glycoside Hydrolases are a class of enzymes that catalyze the hydrolysis of glycosidic bonds, resulting in the breakdown of complex carbohydrates and oligosaccharides into simpler sugars.
Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.
A large and heterogenous group of fungi whose common characteristic is the absence of a sexual state. Many of the pathogenic fungi in humans belong to this group.
Oligosaccharides containing three monosaccharide units linked by glycosidic bonds.
A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.
Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.
Xylose is a monosaccharide, a type of sugar, that is commonly found in woody plants and fruits, and it is used in medical testing to assess the absorptive capacity of the small intestine.
A genus of obligately aerobic, thermophilic, gram-negative bacteria in the family Crenotrichaceae. They were isolated from submarine alkaline HOT SPRINGS in Iceland.
A family of bracket fungi, order POLYPORALES, living in decaying plant matter and timber.
The first stomach of ruminants. It lies on the left side of the body, occupying the whole of the left side of the abdomen and even stretching across the median plane of the body to the right side. It is capacious, divided into an upper and a lower sac, each of which has a blind sac at its posterior extremity. The rumen is lined by mucous membrane containing no digestive glands, but mucus-secreting glands are present in large numbers. Coarse, partially chewed food is stored and churned in the rumen until the animal finds circumstances convenient for rumination. When this occurs, little balls of food are regurgitated through the esophagus into the mouth, and are subjected to a second more thorough mastication, swallowed, and passed on into other parts of the compound stomach. (From Black's Veterinary Dictionary, 17th ed)
Methods and techniques used to genetically modify cells' biosynthetic product output and develop conditions for growing the cells as BIOREACTORS.
The rate dynamics in chemical or physical systems.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
A gram-positive, non-spore-forming group of bacteria comprising organisms that have morphological and physiological characteristics in common.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing. (Grant & Hackh's Chemical Dictionary, 5th ed)
The process of cleaving a chemical compound by the addition of a molecule of water.
Polysaccharides consisting of xylose units.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Arbutin is a natural derivative of hydroquinone, found in the leaves of some plant species, which exhibits skin lightening properties by inhibiting tyrosinase activity and reducing melanin production.

Characterization and cloning of celR, a transcriptional regulator of cellulase genes from Thermomonospora fusca. (1/307)

CelR, a protein that regulates transcription of cellulase genes in Thermomonospora fusca (Actinomycetaceae) was purified to homogeneity. A 6-kilobase NotI-SacI fragment of T. fusca DNA containing the celR gene was cloned into Esherichia coli and sequenced. The celR gene encodes a 340-residue polypeptide that is highly homologous to members of the GalR-LacI family of bacterial transcriptional regulators. CelR specifically binds to a 14-base pair inverted repeat, which has sequence similarity to the binding sites of other family members. This site is present in regions upstream of all six cellulase genes in T. fusca. The binding of CelR to the celE promoter is inhibited specifically by low concentrations of cellobiose (0.2-0.5 mM), the major end product of cellulases. The other sugars tested did not affect binding at equivalent or 50-fold higher concentrations. The results suggest that CelR may act as a repressor, and that the mechanism of induction involves a direct interaction of CelR with cellobiose.  (+info)

Growth of Azospirillum irakense KBC1 on the aryl beta-glucoside salicin requires either salA or salB. (2/307)

The rhizosphere nitrogen-fixing bacterium Azospirillum irakense KBC1 is able to grow on pectin and beta-glucosides such as cellobiose, arbutin, and salicin. Two adjacent genes, salA and salB, conferring beta-glucosidase activity to Escherichia coli, have been identified in a cosmid library of A. irakense DNA. The SalA and SalB enzymes preferentially hydrolyzed aryl beta-glucosides. A Delta(salA-salB) A. irakense mutant was not able to grow on salicin but could still utilize arbutin, cellobiose, and glucose for growth. This mutant could be complemented by either salA or salB, suggesting functional redundancy of these genes in salicin utilization. In contrast to this functional homology, the SalA and SalB proteins, members of family 3 of the glycosyl hydrolases, show a low degree of amino acid similarity. Unlike SalA, the SalB protein exhibits an atypical truncated C-terminal region. We propose that SalA and SalB are representatives of the AB and AB' subfamilies, respectively, in glycosyl hydrolase family 3. This is the first genetic implication of this beta-glucosidase family in the utilization of beta-glucosides for microbial growth.  (+info)

Carbon and electron flow in Clostridium cellulolyticum grown in chemostat culture on synthetic medium. (3/307)

Previous results indicated poor sugar consumption and early inhibition of metabolism and growth when Clostridium cellulolyticum was cultured on medium containing cellobiose and yeast extract. Changing from complex medium to a synthetic medium had a strong effect on (i) the specific cellobiose consumption, which was increased threefold; and (ii) the electron flow, since the NADH/NAD+ ratios ranged from 0.29 to 2.08 on synthetic medium whereas ratios as high as 42 to 57 on complex medium were observed. These data indicate a better control of the carbon flow on mineral salts medium than on complex medium. By continuous culture, it was shown that the electron flow from glycolysis was balanced by the production of hydrogen gas, ethanol, and lactate. At low levels of carbon flow, pyruvate was preferentially cleaved to acetate and ethanol, enabling the bacteria to maximize ATP formation. A high catabolic rate led to pyruvate overflow and to increased ethanol and lactate production. In vitro, glyceraldehyde-3-phosphate dehydrogenase, lactate dehydrogenase, and ethanol dehydrogenase levels were higher under conditions giving higher in vivo specific production rates. Redox balance is essentially maintained by NADH-ferredoxin reductase-hydrogenase at low levels of carbon flow and by ethanol dehydrogenase and lactate dehydrogenase at high levels of carbon flow. The same maximum growth rate (0.150 h-1) was found in both mineral salts and complex media, proving that the uptake of nutrients or the generation of biosynthetic precursors occurred faster than their utilization. On synthetic medium, cellobiose carbon was converted into cell mass and catabolized to produce ATP, while on complex medium, it served mainly as an energy supply and, if present in excess, led to an accumulation of intracellular metabolites as demonstrated for NADH. Cells grown on synthetic medium and at high levels of carbon flow were able to induce regulatory responses such as the production of ethanol and lactate dehydrogenase.  (+info)

Cellobiose transport by mixed ruminal bacteria from a Cow. (4/307)

The transport of cellobiose in mixed ruminal bacteria harvested from a holstein cow fed an Italian ryegrass hay was determined in the presence of nojirimycin-1-sulfate, which almost inhibited cellobiase activity. The kinetic parameters of cellobiose uptake were 14 microM for the Km and 10 nmol/min/mg of protein for the Vmax. Extracellular and cell-associated cellobiases were detected in the rumen, with both showing higher Vmax values and lower affinities than those determined for cellobiose transport. The proportion of cellobiose that was directly transported before it was extracellularly degraded into glucose increased as the cellobiose concentration decreased, reaching more than 20% at the actually observed levels of cellobiose in the rumen, which were less than 0.02 mM. The inhibitor experiment showed that cellobiose was incorporated into the cells mainly by the phosphoenolpyruvate phosphotransferase system and partially by an ATP-dependent and proton-motive-force-independent active transport system. This finding was also supported by determinations of phosphoenolpyruvate phosphotransferase-dependent NADH oxidation with cellobiose and the effects of artificial potentials on cellobiose transport. Cellobiose uptake was sensitive to a decrease in pH (especially below 6.0), and it was weakly but significantly inhibited in the presence of glucose.  (+info)

Characterization of the binding protein-dependent cellobiose and cellotriose transport system of the cellulose degrader Streptomyces reticuli. (5/307)

Streptomyces reticuli has an inducible ATP-dependent uptake system specific for cellobiose and cellotriose. By reversed genetics a gene cluster encoding components of a binding protein-dependent cellobiose and cellotriose ABC transporter was cloned and sequenced. The deduced gene products comprise a regulatory protein (CebR), a cellobiose binding lipoprotein (CebE), two integral membrane proteins (CebF and CebG), and the NH2-terminal part of an intracellular beta-glucosidase (BglC). The gene for the ATP binding protein MsiK is not linked to the ceb operon. We have shown earlier that MsiK is part of two different ABC transport systems, one for maltose and one for cellobiose and cellotriose, in S. reticuli and Streptomyces lividans. Transcription of polycistronic cebEFG and bglC mRNAs is induced by cellobiose, whereas the cebR gene is transcribed independently. Immunological experiments showed that CebE is synthesized during growth with cellobiose and that MsiK is produced in the presence of several sugars at high or moderate levels. The described ABC transporter is the first one of its kind and is the only specific cellobiose/cellotriose uptake system of S. reticuli, since insertional inactivation of the cebE gene prevents high-affinity uptake of cellobiose.  (+info)

Microbial reduction of Fe(III) in acidic sediments: isolation of Acidiphilium cryptum JF-5 capable of coupling the reduction of Fe(III) to the oxidation of glucose. (6/307)

To evaluate the microbial populations involved in the reduction of Fe(III) in an acidic, iron-rich sediment, the anaerobic flow of supplemental carbon and reductant was evaluated in sediment microcosms at the in situ temperature of 12 degrees C. Supplemental glucose and cellobiose stimulated the formation of Fe(II); 42 and 21% of the reducing equivalents that were theoretically obtained from glucose and cellobiose, respectively, were recovered in Fe(II). Likewise, supplemental H(2) was consumed by acidic sediments and yielded additional amounts of Fe(II) in a ratio of approximately 1:2. In contrast, supplemental lactate did not stimulate the formation of Fe(II). Supplemental acetate was not consumed and inhibited the formation of Fe(II). Most-probable-number estimates demonstrated that glucose-utilizing acidophilic Fe(III)-reducing bacteria approximated to 1% of the total direct counts of 4', 6-diamidino-2-phenylindole-stained bacteria. From the highest growth-positive dilution of the most-probable-number series at pH 2. 3 supplemented with glucose, an isolate, JF-5, that could dissimilate Fe(III) was obtained. JF-5 was an acidophilic, gram-negative, facultative anaerobe that completely oxidized the following substrates via the dissimilation of Fe(III): glucose, fructose, xylose, ethanol, glycerol, malate, glutamate, fumarate, citrate, succinate, and H(2). Growth and the reduction of Fe(III) did not occur in the presence of acetate. Cells of JF-5 grown under Fe(III)-reducing conditions formed blebs, i.e., protrusions that were still in contact with the cytoplasmic membrane. Analysis of the 16S rRNA gene sequence of JF-5 demonstrated that it was closely related to an Australian isolate of Acidiphilium cryptum (99.6% sequence similarity), an organism not previously shown to couple the complete oxidation of sugars to the reduction of Fe(III). These collective results indicate that the in situ reduction of Fe(III) in acidic sediments can be mediated by heterotrophic Acidiphilium species that are capable of coupling the reduction of Fe(III) to the complete oxidation of a large variety of substrates including glucose and H(2).  (+info)

Identification of Ruminococcus flavefaciens as the predominant cellulolytic bacterial species of the equine cecum. (7/307)

Detection and quantification of cellulolytic bacteria with oligonucleotide probes showed that Ruminococcus flavefaciens was the predominant species in the pony and donkey cecum. Fibrobacter succinogenes and Ruminococcus albus were present at low levels. Four isolates, morphologically resembling R. flavefaciens, differed from ruminal strains by their carbohydrate utilization and their end products of cellobiose fermentation.  (+info)

The bvr locus of Listeria monocytogenes mediates virulence gene repression by beta-glucosides. (8/307)

The beta-glucoside cellobiose has been reported to specifically repress the PrfA-dependent virulence genes hly and plcA in Listeria monocytogenes NCTC 7973. This led to the hypothesis that beta-glucosides, sugars of plant origin, may act as signal molecules, preventing the expression of virulence genes if L. monocytogenes is living in its natural habitat (soil). In three other laboratory strains (EGD, L028, and 10403S), however, the effect of cellobiose was not unique, and all fermentable carbohydrates repressed hly. This suggested that the downregulation of virulence genes by beta-glucosides is not a specific phenomenon but, rather, an aspect of a global regulatory mechanism of catabolite repression (CR). We assessed the effect of carbohydrates on virulence gene expression in a panel of wild-type isolates of L. monocytogenes by using the PrfA-dependent phospholipase C gene plcB as a reporter. Utilization of any fermentable sugar caused plcB repression in wild-type L. monocytogenes. However, an EGD variant was identified in which, as in NCTC 7973, plcB was only repressed by beta-glucosides. Thus, the regulation of L. monocytogenes virulence genes by sugars appears to be mediated by two separate mechanisms, one presumably involving a CR pathway and another specifically responding to beta-glucosides. We have identified in L. monocytogenes a 4-kb operon, bvrABC, encoding an antiterminator of the BglG family (bvrA), a beta-glucoside-specific enzyme II permease component of the phosphoenolpyruvate-sugar phosphotransferase system (bvrB), and a putative ADP-ribosylglycohydrolase (bvrC). Low-stringency Southern blots showed that this locus is absent from other Listeria spp. Transcription of bvrB was induced by cellobiose and salicin but not by arbutin. Disruption of the bvr operon by replacing part of bvrAB with an interposon abolished the repression by cellobiose and salicin but not that by arbutin. Our data indicate that the bvr locus encodes a beta-glucoside-specific sensor that mediates virulence gene repression upon detection of cellobiose and salicin. Bvr is the first sensory system found in L. monocytogenes that is involved in environmental regulation of virulence genes.  (+info)

Cellobiose is a disaccharide made up of two molecules of glucose joined by a β-1,4-glycosidic bond. It is formed when cellulose or beta-glucans are hydrolyzed, and it can be further broken down into its component glucose molecules by the action of the enzyme beta-glucosidase. Cellobiose has a sweet taste, but it is not as sweet as sucrose (table sugar). It is used in some industrial processes and may have potential applications in the food industry.

Carbohydrate dehydrogenases are a group of enzymes that catalyze the oxidation of carbohydrates, including sugars and sugar alcohols. These enzymes play a crucial role in cellular metabolism by helping to convert these molecules into forms that can be used for energy or as building blocks for other biological compounds.

During the oxidation process, carbohydrate dehydrogenases remove hydrogen atoms from the carbohydrate substrate and transfer them to an electron acceptor, such as NAD+ or FAD. This results in the formation of a ketone or aldehyde group on the carbohydrate molecule and the reduction of the electron acceptor to NADH or FADH2.

Carbohydrate dehydrogenases are classified into several subgroups based on their substrate specificity, cofactor requirements, and other factors. Some examples include glucose dehydrogenase, galactose dehydrogenase, and sorbitol dehydrogenase.

These enzymes have important applications in various fields, including biotechnology, medicine, and industry. For example, they can be used to detect or quantify specific carbohydrates in biological samples, or to produce valuable chemical compounds through the oxidation of renewable resources such as plant-derived sugars.

Cellulose is a complex carbohydrate that is the main structural component of the cell walls of green plants, many algae, and some fungi. It is a polysaccharide consisting of long chains of beta-glucose molecules linked together by beta-1,4 glycosidic bonds. Cellulose is insoluble in water and most organic solvents, and it is resistant to digestion by humans and non-ruminant animals due to the lack of cellulase enzymes in their digestive systems. However, ruminants such as cows and sheep can digest cellulose with the help of microbes in their rumen that produce cellulase.

Cellulose has many industrial applications, including the production of paper, textiles, and building materials. It is also used as a source of dietary fiber in human food and animal feed. Cellulose-based materials are being explored for use in biomedical applications such as tissue engineering and drug delivery due to their biocompatibility and mechanical properties.

Beta-glucosidase is an enzyme that breaks down certain types of complex sugars, specifically those that contain a beta-glycosidic bond. This enzyme is found in various organisms, including humans, and plays a role in the digestion of some carbohydrates, such as cellulose and other plant-based materials.

In the human body, beta-glucosidase is produced by the lysosomes, which are membrane-bound organelles found within cells that help break down and recycle various biological molecules. Beta-glucosidase is involved in the breakdown of glycolipids and gangliosides, which are complex lipids that contain sugar molecules.

Deficiencies in beta-glucosidase activity can lead to certain genetic disorders, such as Gaucher disease, in which there is an accumulation of glucocerebrosidase, a type of glycolipid, within the lysosomes. This can result in various symptoms, including enlargement of the liver and spleen, anemia, and bone pain.

Cellulase is a type of enzyme that breaks down cellulose, which is a complex carbohydrate and the main structural component of plant cell walls. Cellulases are produced by certain bacteria, fungi, and protozoans, and are used in various industrial applications such as biofuel production, food processing, and textile manufacturing. In the human body, there are no known physiological roles for cellulases, as humans do not produce these enzymes and cannot digest cellulose.

Dextrins are a group of carbohydrates that are produced by the hydrolysis of starches. They are made up of shorter chains of glucose molecules than the original starch, and their molecular weight and physical properties can vary depending on the degree of hydrolysis. Dextrins are often used in food products as thickeners, stabilizers, and texturizers, and they also have applications in industry as adhesives and binders. In a medical context, dextrins may be used as a source of calories for patients who have difficulty digesting other types of carbohydrates.

Disaccharides are a type of carbohydrate that is made up of two monosaccharide units bonded together. Monosaccharides are simple sugars, such as glucose, fructose, or galactose. When two monosaccharides are joined together through a condensation reaction, they form a disaccharide.

The most common disaccharides include:

* Sucrose (table sugar), which is composed of one glucose molecule and one fructose molecule.
* Lactose (milk sugar), which is composed of one glucose molecule and one galactose molecule.
* Maltose (malt sugar), which is composed of two glucose molecules.

Disaccharides are broken down into their component monosaccharides during digestion by enzymes called disaccharidases, which are located in the brush border of the small intestine. These enzymes catalyze the hydrolysis of the glycosidic bond that links the two monosaccharides together, releasing them to be absorbed into the bloodstream and used for energy.

Disorders of disaccharide digestion and absorption can lead to various symptoms, such as bloating, diarrhea, and abdominal pain. For example, lactose intolerance is a common condition in which individuals lack sufficient levels of the enzyme lactase, leading to an inability to properly digest lactose and resulting in gastrointestinal symptoms.

"Phanerochaete" is a genus of saprotrophic fungi in the family Phanerochaetaceae. These fungi are characterized by their ability to degrade lignocellulosic materials, making them important decomposers in many ecosystems. They produce various extracellular enzymes that break down complex polymers such as cellulose and lignin, which are abundant in plant biomass. The genus Phanerochaete includes several species with medical relevance due to their potential role in human health and disease. For instance, some species have been studied for their ability to produce bioactive compounds with antimicrobial or anti-inflammatory properties. However, it is important to note that most Phanerochaete species are not typically associated with human diseases and are generally considered to be beneficial organisms in natural environments.

Glucan 1,4-beta-Glucosidase is an enzyme that breaks down certain types of complex carbohydrates known as beta-glucans. Specifically, this enzyme hydrolyzes the beta-1,4 glycosidic bonds in glucans, releasing individual glucose molecules. It is found in various organisms, including bacteria, fungi, and plants. In humans, it plays a role in the digestion of certain dietary fibers and may have potential applications in medical and industrial settings, such as in the treatment of bacterial infections or the production of biofuels.

Cellulose 1,4-beta-Cellobiosidase is an enzyme that catalyzes the hydrolysis of cellulose, a complex carbohydrate and the main structural component of plant cell walls, into simpler sugars. Specifically, this enzyme breaks down cellulose by cleaving the 1,4-beta-glycosidic bonds between the cellobiose units that make up the cellulose polymer, releasing individual cellobiose molecules (disaccharides consisting of two glucose molecules). This enzyme is also known as cellobiohydrolase or beta-1,4-D-glucan cellobiohydrolase. It plays a crucial role in the natural breakdown of plant material and is widely used in various industrial applications, such as biofuel production and pulp and paper manufacturing.

"Sporothrix" is a genus of fungi that includes several species, the most well-known of which is "Sporothrix schenckii." This particular species is an environmental saprophyte, commonly found in soil, plant matter, and decaying organic material. It can cause a disease in humans and animals known as sporotrichosis, which is a subcutaneous infection that typically affects the skin and underlying tissue. The infection usually occurs after traumatic inoculation of the fungus through the skin, often from activities such as gardening or handling contaminated plant material.

The infection initially presents as a painless, nodular lesion at the site of inoculation, which can later ulcerate and spread to other parts of the body through lymphatic channels. Disseminated sporotrichosis is rare but can occur in immunocompromised individuals, affecting various organs such as the lungs, bones, and central nervous system.

Proper diagnosis of sporotrichosis involves direct examination and culture of clinical specimens, as well as serological tests and molecular techniques. Treatment typically includes oral antifungal medications such as itraconazole or posaconazole, although amphotericin B may be required in severe cases or in patients with compromised immune systems.

Tetroses are a type of monosaccharides, which are simple sugars that cannot be broken down into simpler units by hydrolysis. Tetroses have four carbon atoms and are aldotetroses, meaning they contain an aldehyde functional group at the first carbon atom.

There are two naturally occurring tetroses: erythrose and threose. Erythrose has its hydroxyl groups on the second and fourth carbon atoms, while threose has its hydroxyl groups on the second and third carbon atoms. Tetroses can participate in various chemical reactions, including forming glycosidic bonds with other monosaccharides to create disaccharides or polysaccharides. However, tetroses are not as common as other monosaccharides, such as pentoses and hexoses.

Ruminococcus is a genus of obligate anaerobic, gram-positive bacteria that are commonly found in the gastrointestinal tracts of humans and other animals. These bacteria play a crucial role in breaking down complex carbohydrates and fibers in the gut through fermentation, producing short-chain fatty acids (SCFAs) as byproducts. Ruminococcus species are particularly abundant in the rumen of ruminants such as cows and sheep, where they help to digest plant material. In humans, Ruminococcus species have been associated with various aspects of health and disease, including gut inflammation, colon cancer, and metabolic disorders. However, more research is needed to fully understand the complex relationship between these bacteria and human health.

Basidiomycota is a phylum in the kingdom Fungi that consists of organisms commonly known as club fungi or club mushrooms. The name Basidiomycota is derived from the presence of a characteristic reproductive structure called a basidium, which is where spores are produced.

The basidiomycetes include many familiar forms such as mushrooms, toadstools, bracket fungi, and other types of polypores. They have a complex life cycle that involves both sexual and asexual reproduction. The sexual reproductive stage produces a characteristic fruiting body, which may be microscopic or highly visible, depending on the species.

Basidiomycota fungi play important ecological roles in decomposing organic matter, forming mutualistic relationships with plants, and acting as parasites on other organisms. Some species are economically important, such as edible mushrooms, while others can be harmful or even deadly to humans and animals.

'Clostridium' is a genus of gram-positive, rod-shaped bacteria that are widely distributed in nature, including in soil, water, and the gastrointestinal tracts of animals and humans. Many species of Clostridium are anaerobic, meaning they can grow and reproduce in environments with little or no oxygen. Some species of Clostridium are capable of producing toxins that can cause serious and sometimes life-threatening illnesses in humans and animals.

Some notable species of Clostridium include:

* Clostridium tetani, which causes tetanus (also known as lockjaw)
* Clostridium botulinum, which produces botulinum toxin, the most potent neurotoxin known and the cause of botulism
* Clostridium difficile, which can cause severe diarrhea and colitis, particularly in people who have recently taken antibiotics
* Clostridium perfringens, which can cause food poisoning and gas gangrene.

It is important to note that not all species of Clostridium are harmful, and some are even beneficial, such as those used in the production of certain fermented foods like sauerkraut and natto. However, due to their ability to produce toxins and cause illness, it is important to handle and dispose of materials contaminated with Clostridium species carefully, especially in healthcare settings.

Glucosidases are a group of enzymes that catalyze the hydrolysis of glycosidic bonds, specifically at the non-reducing end of an oligo- or poly saccharide, releasing a single sugar molecule, such as glucose. They play important roles in various biological processes, including digestion of carbohydrates and the breakdown of complex glycans in glycoproteins and glycolipids.

In the context of digestion, glucosidases are produced by the pancreas and intestinal brush border cells to help break down dietary polysaccharides (e.g., starch) into monosaccharides (glucose), which can then be absorbed by the body for energy production or storage.

There are several types of glucosidases, including:

1. α-Glucosidase: This enzyme is responsible for cleaving α-(1→4) and α-(1→6) glycosidic bonds in oligosaccharides and disaccharides, such as maltose, maltotriose, and isomaltose.
2. β-Glucosidase: This enzyme hydrolyzes β-(1→4) glycosidic bonds in cellobiose and other oligosaccharides derived from plant cell walls.
3. Lactase (β-Galactosidase): Although not a glucosidase itself, lactase is often included in this group because it hydrolyzes the β-(1→4) glycosidic bond between glucose and galactose in lactose, yielding free glucose and galactose.

Deficiencies or inhibition of these enzymes can lead to various medical conditions, such as congenital sucrase-isomaltase deficiency (an α-glucosidase deficiency), lactose intolerance (a lactase deficiency), and Gaucher's disease (a β-glucocerebrosidase deficiency).

'Gram-negative anaerobic straight, curved, and helical rods' are categories of bacteria that do not stain gram-positive during the Gram staining procedure, lack a outer layer of peptidoglycan, and do not require oxygen to grow. They can be further classified into different genera and species based on their shape and other microbiological and biochemical characteristics. Some examples of gram-negative anaerobic rods include Bacteroides, Prevotella, Porphyromonas, Fusobacterium, and Campylobacter. These bacteria are often found in the human oral cavity, gastrointestinal tract, and female genital tract and can cause a variety of infections such as abscesses, bacteremia, pneumonia, and meningitis.

Fermentation is a metabolic process in which an organism converts carbohydrates into alcohol or organic acids using enzymes. In the absence of oxygen, certain bacteria, yeasts, and fungi convert sugars into carbon dioxide, hydrogen, and various end products, such as alcohol, lactic acid, or acetic acid. This process is commonly used in food production, such as in making bread, wine, and beer, as well as in industrial applications for the production of biofuels and chemicals.

Peptococcaceae is a family of obligately anaerobic, non-spore forming, gram-positive cocci that are found as normal flora in the human gastrointestinal tract. These bacteria are commonly isolated from feces and are known to be associated with various human infections, particularly intra-abdominal abscesses, bacteremia, and brain abscesses. The genus Peptococcus includes several species, such as Peptococcus niger and Peptococcus saccharolyticus, which are known to be associated with human infections. However, it is important to note that the taxonomy of this group of bacteria has undergone significant revisions in recent years, and some species previously classified as Peptococcaceae have been reassigned to other families.

Cellulases are a group of enzymes that break down cellulose, which is a complex carbohydrate and the main structural component of plant cell walls. These enzymes are produced by various organisms, including bacteria, fungi, and protozoa. They play an important role in the natural decomposition process and have various industrial applications, such as in the production of biofuels, paper, and textiles.

Cellulases work by hydrolyzing the beta-1,4 glycosidic bonds between the glucose molecules that make up cellulose, breaking it down into simpler sugars like glucose. This process is known as saccharification. The specific type of cellulase enzyme determines where on the cellulose molecule it will cleave the bond.

There are three main types of cellulases: endoglucanases, exoglucanases, and beta-glucosidases. Endoglucanases randomly attack internal bonds in the amorphous regions of cellulose, creating new chain ends for exoglucanases to act on. Exoglucanases (also known as cellobiohydrolases) cleave cellobiose units from the ends of the cellulose chains, releasing cellobiose or glucose. Beta-glucosidases convert cellobiose into two molecules of glucose, which can then be further metabolized by the organism.

In summary, cellulases are a group of enzymes that break down cellulose into simpler sugars through hydrolysis. They have various industrial applications and play an essential role in natural decomposition processes.

Trichoderma is a genus of fungi that are commonly found in soil, decaying wood, and other organic matter. While there are many different species of Trichoderma, some of them have been studied for their potential use in various medical and industrial applications. For example, certain Trichoderma species have been shown to have antimicrobial properties and can be used to control plant diseases. Other species are being investigated for their ability to produce enzymes and other compounds that may have industrial or medicinal uses.

However, it's important to note that not all Trichoderma species are beneficial, and some of them can cause infections in humans, particularly in individuals with weakened immune systems. These infections can be difficult to diagnose and treat, as they often involve multiple organ systems and may require aggressive antifungal therapy.

In summary, Trichoderma is a genus of fungi that can have both beneficial and harmful effects on human health, depending on the specific species involved and the context in which they are encountered.

'Clostridium thermocellum' is a type of anaerobic, gram-positive bacterium that is known for its ability to produce cellulases and break down cellulose. It is thermophilic, meaning it grows optimally at higher temperatures, typically between 55-70°C. This organism is of interest in the field of bioenergy because of its potential to convert plant biomass into useful products such as biofuels. However, it's important to note that this bacterium can also produce harmful metabolic byproducts and can be potentially pathogenic to humans.

Glucosides are chemical compounds that consist of a glycosidic bond between a sugar molecule (typically glucose) and another non-sugar molecule, which can be an alcohol, phenol, or steroid. They occur naturally in various plants and some microorganisms.

Glucosides are not medical terms per se, but they do have significance in pharmacology and toxicology because some of them may release the sugar portion upon hydrolysis, yielding aglycone, which can have physiological effects when ingested or absorbed into the body. Some glucosides are used as medications or dietary supplements due to their therapeutic properties, while others can be toxic if consumed in large quantities.

Substrate specificity in the context of medical biochemistry and enzymology refers to the ability of an enzyme to selectively bind and catalyze a chemical reaction with a particular substrate (or a group of similar substrates) while discriminating against other molecules that are not substrates. This specificity arises from the three-dimensional structure of the enzyme, which has evolved to match the shape, charge distribution, and functional groups of its physiological substrate(s).

Substrate specificity is a fundamental property of enzymes that enables them to carry out highly selective chemical transformations in the complex cellular environment. The active site of an enzyme, where the catalysis takes place, has a unique conformation that complements the shape and charge distribution of its substrate(s). This ensures efficient recognition, binding, and conversion of the substrate into the desired product while minimizing unwanted side reactions with other molecules.

Substrate specificity can be categorized as:

1. Absolute specificity: An enzyme that can only act on a single substrate or a very narrow group of structurally related substrates, showing no activity towards any other molecule.
2. Group specificity: An enzyme that prefers to act on a particular functional group or class of compounds but can still accommodate minor structural variations within the substrate.
3. Broad or promiscuous specificity: An enzyme that can act on a wide range of structurally diverse substrates, albeit with varying catalytic efficiencies.

Understanding substrate specificity is crucial for elucidating enzymatic mechanisms, designing drugs that target specific enzymes or pathways, and developing biotechnological applications that rely on the controlled manipulation of enzyme activities.

Glycoside hydrolases are a class of enzymes that catalyze the hydrolysis of glycosidic bonds found in various substrates such as polysaccharides, oligosaccharides, and glycoproteins. These enzymes break down complex carbohydrates into simpler sugars by cleaving the glycosidic linkages that connect monosaccharide units.

Glycoside hydrolases are classified based on their mechanism of action and the type of glycosidic bond they hydrolyze. The classification system is maintained by the International Union of Biochemistry and Molecular Biology (IUBMB). Each enzyme in this class is assigned a unique Enzyme Commission (EC) number, which reflects its specificity towards the substrate and the type of reaction it catalyzes.

These enzymes have various applications in different industries, including food processing, biofuel production, pulp and paper manufacturing, and biomedical research. In medicine, glycoside hydrolases are used to diagnose and monitor certain medical conditions, such as carbohydrate-deficient glycoprotein syndrome, a rare inherited disorder affecting the structure of glycoproteins.

Glucosyltransferases (GTs) are a group of enzymes that catalyze the transfer of a glucose molecule from an activated donor to an acceptor molecule, resulting in the formation of a glycosidic bond. These enzymes play crucial roles in various biological processes, including the biosynthesis of complex carbohydrates, cell wall synthesis, and protein glycosylation. In some cases, GTs can also contribute to bacterial pathogenesis by facilitating the attachment of bacteria to host tissues through the formation of glucans, which are polymers of glucose molecules.

GTs can be classified into several families based on their sequence similarities and catalytic mechanisms. The donor substrates for GTs are typically activated sugars such as UDP-glucose, TDP-glucose, or GDP-glucose, which serve as the source of the glucose moiety that is transferred to the acceptor molecule. The acceptor can be a wide range of molecules, including other sugars, proteins, lipids, or small molecules.

In the context of human health and disease, GTs have been implicated in various pathological conditions, such as cancer, inflammation, and microbial infections. For example, some GTs can modify proteins on the surface of cancer cells, leading to increased cell proliferation, migration, and invasion. Additionally, GTs can contribute to bacterial resistance to antibiotics by modifying the structure of bacterial cell walls or by producing biofilms that protect bacteria from host immune responses and antimicrobial agents.

Overall, Glucosyltransferases are essential enzymes involved in various biological processes, and their dysregulation has been associated with several human diseases. Therefore, understanding the structure, function, and regulation of GTs is crucial for developing novel therapeutic strategies to target these enzymes and treat related pathological conditions.

Mitosporic fungi, also known as asexual fungi or anamorphic fungi, are a group of fungi that produce mitospores (also called conidia) during their asexual reproduction. Mitospores are produced from the tip of specialized hyphae called conidiophores and are used for dispersal and survival of the fungi in various environments. These fungi do not have a sexual reproductive stage or it has not been observed, making their taxonomic classification challenging. They are commonly found in soil, decaying organic matter, and water, and some of them can cause diseases in humans, animals, and plants. Examples of mitosporic fungi include Aspergillus, Penicillium, and Fusarium species.

A trisaccharide is a type of carbohydrate molecule composed of three monosaccharide units joined together by glycosidic bonds. Monosaccharides are simple sugars, such as glucose, fructose, and galactose, which serve as the building blocks of more complex carbohydrates.

In a trisaccharide, two monosaccharides are linked through a glycosidic bond to form a disaccharide, and then another monosaccharide is attached to the disaccharide via another glycosidic bond. The formation of these bonds involves the loss of a water molecule (dehydration synthesis) between the hemiacetal or hemiketal group of one monosaccharide and the hydroxyl group of another.

Examples of trisaccharides include raffinose (glucose + fructose + galactose), maltotriose (glucose + glucose + glucose), and melezitose (glucose + fructose + glucose). Trisaccharides can be found naturally in various foods, such as honey, sugar beets, and some fruits and vegetables. They play a role in energy metabolism, serving as an energy source for the body upon digestion into monosaccharides, which are then absorbed into the bloodstream and transported to cells for energy production or storage.

Carboxymethylcellulose sodium is a type of cellulose derivative that is widely used in the medical and pharmaceutical fields as an excipient or a drug delivery agent. It is a white, odorless powder with good water solubility and forms a clear, viscous solution.

Chemically, carboxymethylcellulose sodium is produced by reacting cellulose, which is derived from plant sources such as wood or cotton, with sodium hydroxide and chloroacetic acid. This reaction introduces carboxymethyl groups (-CH2COO-) to the cellulose molecule, making it more soluble in water and providing negative charges that can interact with positively charged ions or drugs.

In medical applications, carboxymethylcellulose sodium is used as a thickening agent, binder, disintegrant, and suspending agent in various pharmaceutical formulations such as tablets, capsules, liquids, and semisolids. It can also be used as a lubricant in the manufacture of tablets and capsules to facilitate their ejection from molds or dies.

Carboxymethylcellulose sodium has been shown to have good biocompatibility and low toxicity, making it a safe and effective excipient for use in medical and pharmaceutical applications. However, like any other excipient, it should be used with caution and in appropriate amounts to avoid any adverse effects or interactions with the active ingredients of the drug product.

Carbohydrate metabolism is the process by which the body breaks down carbohydrates into glucose, which is then used for energy or stored in the liver and muscles as glycogen. This process involves several enzymes and chemical reactions that convert carbohydrates from food into glucose, fructose, or galactose, which are then absorbed into the bloodstream and transported to cells throughout the body.

The hormones insulin and glucagon regulate carbohydrate metabolism by controlling the uptake and storage of glucose in cells. Insulin is released from the pancreas when blood sugar levels are high, such as after a meal, and promotes the uptake and storage of glucose in cells. Glucagon, on the other hand, is released when blood sugar levels are low and signals the liver to convert stored glycogen back into glucose and release it into the bloodstream.

Disorders of carbohydrate metabolism can result from genetic defects or acquired conditions that affect the enzymes or hormones involved in this process. Examples include diabetes, hypoglycemia, and galactosemia. Proper management of these disorders typically involves dietary modifications, medication, and regular monitoring of blood sugar levels.

Xylose is a type of sugar that is commonly found in plants and wood. In the context of medical definitions, xylose is often used in tests to assess the function of the small intestine. The most common test is called the "xylose absorption test," which measures the ability of the small intestine to absorb this sugar.

In this test, a patient is given a small amount of xylose to drink, and then several blood and/or urine samples are collected over the next few hours. The amount of xylose that appears in these samples is measured and used to determine how well the small intestine is absorbing nutrients.

Abnormal results on a xylose absorption test can indicate various gastrointestinal disorders, such as malabsorption syndromes, celiac disease, or bacterial overgrowth in the small intestine.

"Rhodothermus" is not a medical term, but rather a genus name in the domain Bacteria. It belongs to the family Rhodothermaceae and is characterized by its ability to thrive in high-temperature environments, with an optimum growth temperature of around 65-70°C. These bacteria are typically found in marine hot springs and deep-sea hydrothermal vents. They play a role in the global carbon cycle by breaking down complex organic matter into simpler compounds, which can then be used by other organisms.

Therefore, "Rhodothermus" is not directly related to medical terminology or human health. However, understanding the biology and ecology of these extremophilic bacteria can provide insights into the fundamental principles of life and may have potential applications in biotechnology and industrial processes.

I apologize for any confusion, but "Polyporaceae" is not a medical term. It is a taxonomic category in mycology, which is the branch of biology that deals with the study of fungi.

Polyporaceae is a family of fungi that includes various types of polypores, which are characterized by having pores on the underside of their fruiting bodies (the above-ground reproductive structures) instead of gills. These fungi are mostly saprotrophic, meaning they decompose dead or decaying organic matter to obtain nutrients. Some species can also be parasitic and cause diseases in living trees.

Examples of genera within Polyporaceae include Trametes, Ganoderma, Fomes, and Irpex, among others. If you have any questions related to medical terminology or concepts, please feel free to ask!

The rumen is the largest compartment of the stomach in ruminant animals, such as cows, goats, and sheep. It is a specialized fermentation chamber where microbes break down tough plant material into nutrients that the animal can absorb and use for energy and growth. The rumen contains billions of microorganisms, including bacteria, protozoa, and fungi, which help to break down cellulose and other complex carbohydrates in the plant material through fermentation.

The rumen is characterized by its large size, muscular walls, and the presence of a thick mat of partially digested food and microbes called the rumen mat or cud. The animal regurgitates the rumen contents periodically to chew it again, which helps to break down the plant material further and mix it with saliva, creating a more favorable environment for fermentation.

The rumen plays an essential role in the digestion and nutrition of ruminant animals, allowing them to thrive on a diet of low-quality plant material that would be difficult for other animals to digest.

Metabolic engineering is a branch of biotechnology that involves the modification and manipulation of metabolic pathways in organisms to enhance their production of specific metabolites or to alter their flow of energy and carbon. This field combines principles from genetics, molecular biology, biochemistry, and chemical engineering to design and construct novel metabolic pathways or modify existing ones with the goal of optimizing the production of valuable compounds or improving the properties of organisms for various applications.

Examples of metabolic engineering include the modification of microorganisms to produce biofuels, pharmaceuticals, or industrial chemicals; the enhancement of crop yields and nutritional value in agriculture; and the development of novel bioremediation strategies for environmental pollution control. The ultimate goal of metabolic engineering is to create organisms that can efficiently and sustainably produce valuable products while minimizing waste and reducing the impact on the environment.

In the context of medicine and pharmacology, "kinetics" refers to the study of how a drug moves throughout the body, including its absorption, distribution, metabolism, and excretion (often abbreviated as ADME). This field is called "pharmacokinetics."

1. Absorption: This is the process of a drug moving from its site of administration into the bloodstream. Factors such as the route of administration (e.g., oral, intravenous, etc.), formulation, and individual physiological differences can affect absorption.

2. Distribution: Once a drug is in the bloodstream, it gets distributed throughout the body to various tissues and organs. This process is influenced by factors like blood flow, protein binding, and lipid solubility of the drug.

3. Metabolism: Drugs are often chemically modified in the body, typically in the liver, through processes known as metabolism. These changes can lead to the formation of active or inactive metabolites, which may then be further distributed, excreted, or undergo additional metabolic transformations.

4. Excretion: This is the process by which drugs and their metabolites are eliminated from the body, primarily through the kidneys (urine) and the liver (bile).

Understanding the kinetics of a drug is crucial for determining its optimal dosing regimen, potential interactions with other medications or foods, and any necessary adjustments for special populations like pediatric or geriatric patients, or those with impaired renal or hepatic function.

Glucose is a simple monosaccharide (or single sugar) that serves as the primary source of energy for living organisms. It's a fundamental molecule in biology, often referred to as "dextrose" or "grape sugar." Glucose has the molecular formula C6H12O6 and is vital to the functioning of cells, especially those in the brain and nervous system.

In the body, glucose is derived from the digestion of carbohydrates in food, and it's transported around the body via the bloodstream to cells where it can be used for energy. Cells convert glucose into a usable form through a process called cellular respiration, which involves a series of metabolic reactions that generate adenosine triphosphate (ATP)—the main currency of energy in cells.

Glucose is also stored in the liver and muscles as glycogen, a polysaccharide (multiple sugar) that can be broken down back into glucose when needed for energy between meals or during physical activity. Maintaining appropriate blood glucose levels is crucial for overall health, and imbalances can lead to conditions such as diabetes mellitus.

"Gram-positive asporegenous rods" is a term used to describe a specific shape and staining characteristic of certain types of bacteria. Here's the medical definition:

Gram-positive: These are bacteria that appear purple or violet when subjected to a Gram stain, a laboratory technique used to classify bacteria based on their cell wall structure. In this method, a primary stain (crystal violet) is applied, followed by a mordant (a substance that helps the dye bind to the bacterial cell). Then, a decolorizer (alcohol or acetone) is used to wash away the primary stain from the Gram-negative bacteria, leaving them unstained. A counterstain (safranin or fuchsin) is then applied, which stains the decolorized Gram-negative bacteria pink or red. However, Gram-positive bacteria retain the primary stain and appear purple or violet.

Asporegenous: These are bacteria that do not form spores under any conditions. Spores are a dormant, tough, and highly resistant form of bacterial cells that can survive extreme environmental conditions. Asporegenous bacteria lack this ability to form spores.

Rods: This term refers to the shape of the bacteria. Rod-shaped bacteria are also known as bacilli. They are longer than they are wide, and their size may vary from 0.5 to several micrometers in length and about 0.2 to 1.0 micrometer in width.

Examples of Gram-positive asporegenous rods include species from the genera Listeria, Corynebacterium, and Bacillus (some strains). These bacteria can cause various diseases, ranging from foodborne illnesses to severe skin and respiratory infections.

Hydrogen-ion concentration, also known as pH, is a measure of the acidity or basicity of a solution. It is defined as the negative logarithm (to the base 10) of the hydrogen ion activity in a solution. The standard unit of measurement is the pH unit. A pH of 7 is neutral, less than 7 is acidic, and greater than 7 is basic.

In medical terms, hydrogen-ion concentration is important for maintaining homeostasis within the body. For example, in the stomach, a high hydrogen-ion concentration (low pH) is necessary for the digestion of food. However, in other parts of the body such as blood, a high hydrogen-ion concentration can be harmful and lead to acidosis. Conversely, a low hydrogen-ion concentration (high pH) in the blood can lead to alkalosis. Both acidosis and alkalosis can have serious consequences on various organ systems if not corrected.

Maltose is a disaccharide made up of two glucose molecules joined by an alpha-1,4 glycosidic bond. It is commonly found in malted barley and is created during the germination process when amylase breaks down starches into simpler sugars. Maltose is less sweet than sucrose (table sugar) and is broken down into glucose by the enzyme maltase during digestion.

Hydrolysis is a chemical process, not a medical one. However, it is relevant to medicine and biology.

Hydrolysis is the breakdown of a chemical compound due to its reaction with water, often resulting in the formation of two or more simpler compounds. In the context of physiology and medicine, hydrolysis is a crucial process in various biological reactions, such as the digestion of food molecules like proteins, carbohydrates, and fats. Enzymes called hydrolases catalyze these hydrolysis reactions to speed up the breakdown process in the body.

Xylans are a type of complex carbohydrate, specifically a hemicellulose, that are found in the cell walls of many plants. They are made up of a backbone of beta-1,4-linked xylose sugar molecules and can be substituted with various side groups such as arabinose, glucuronic acid, and acetyl groups. Xylans are indigestible by humans, but they can be broken down by certain microorganisms in the gut through a process called fermentation, which can produce short-chain fatty acids that have beneficial effects on health.

Culture media is a substance that is used to support the growth of microorganisms or cells in an artificial environment, such as a petri dish or test tube. It typically contains nutrients and other factors that are necessary for the growth and survival of the organisms being cultured. There are many different types of culture media, each with its own specific formulation and intended use. Some common examples include blood agar, which is used to culture bacteria; Sabouraud dextrose agar, which is used to culture fungi; and Eagle's minimum essential medium, which is used to culture animal cells.

Anaerobiosis is a state in which an organism or a portion of an organism is able to live and grow in the absence of molecular oxygen (O2). In biological contexts, "anaerobe" refers to any organism that does not require oxygen for growth, and "aerobe" refers to an organism that does require oxygen for growth.

There are two types of anaerobes: obligate anaerobes, which cannot tolerate the presence of oxygen and will die if exposed to it; and facultative anaerobes, which can grow with or without oxygen but prefer to grow in its absence. Some organisms are able to switch between aerobic and anaerobic metabolism depending on the availability of oxygen, a process known as "facultative anaerobiosis."

Anaerobic respiration is a type of metabolic process that occurs in the absence of molecular oxygen. In this process, organisms use alternative electron acceptors other than oxygen to generate energy through the transfer of electrons during cellular respiration. Examples of alternative electron acceptors include nitrate, sulfate, and carbon dioxide.

Anaerobic metabolism is less efficient than aerobic metabolism in terms of energy production, but it allows organisms to survive in environments where oxygen is not available or is toxic. Anaerobic bacteria are important decomposers in many ecosystems, breaking down organic matter and releasing nutrients back into the environment. In the human body, anaerobic bacteria can cause infections and other health problems if they proliferate in areas with low oxygen levels, such as the mouth, intestines, or deep tissue wounds.

Arbutin is a natural compound found in the leaves of some plants, such as bearberry (Arctostaphylos uva-ursi), cranberry, and blueberry. It is a glycoside of hydroquinone, which means it consists of a molecule of hydroquinone attached to a sugar molecule.

Arbutin has been used in some skincare products as a skin-lightening agent because it inhibits the production of melanin, the pigment that gives skin its color. When applied to the skin, arbutin is broken down into hydroquinone, which has been shown to have skin-lightening effects by interfering with the enzyme tyrosinase, which is involved in melanin production.

However, it's important to note that the use of hydroquinone in skincare products is controversial due to concerns about its potential toxicity and side effects, such as skin irritation and discoloration. Therefore, arbutin may be a safer alternative for those looking for a natural skin-lightening ingredient, but more research is needed to confirm its safety and effectiveness.

"Human Metabolome Database: Showing metabocard for Cellobiose (HMDB0000055)". Braun, G. (1943). "α-Cellobiose Octaacetate" (PDF ... Cellobiose is a disaccharide with the formula (C6H7(OH)4O)2O. It is classified as a reducing sugar. In terms of its chemical ... Cellobiose has eight free alcohol (OH) groups, one acetal linkage and one hemiacetal linkage, which give rise to strong inter- ... Cellobiose can be used as an indicator carbohydrate for Crohn's disease and malabsorption syndrome. Treatment of cellulose with ...
In enzymology a cellobiose epimerase (EC 5.1.3.11) is an enzyme that catalyzes the chemical reaction cellobiose ⇌ {\ ... The systematic name of this enzyme class is cellobiose 2-epimerase. Enzymes like these can produce a more rapid syndrome that ... displaystyle \rightleftharpoons } D-glucosyl-D-mannose Hence, this enzyme has one substrate, cellobiose, and one product, D- ...
In enzymology, a cellobiose phosphorylase (EC 2.4.1.20) is an enzyme that catalyzes the chemical reaction cellobiose + ... The systematic name of this enzyme class is cellobiose:phosphate alpha-D-glucosyltransferase. This enzyme participates in ... Ayers WA (November 1959). "Phosphorolysis and synthesis of cellobiose by cell extracts from Ruminococcus flavefaciens". The ... Alexander JK (June 1968). "Purification and specificity of cellobiose phosphorylase from Clostridium thermocellum". The Journal ...
... cellobiose oxidoreductase, Phanerochaete chrysosporium cellobiose oxidoreductase, CBOR, cellobiose oxidase, cellobiose:oxygen 1 ... The systematic name of this enzyme class is cellobiose:acceptor 1-oxidoreductase. Other names in common use include cellobiose ... cellobiose, and lactose, whereas Class II CDHs have been applied for the detection of cellobiose, lactose, maltose and glucose ... The B-site holds the non-reducing end of cellobiose in position whereas at the C-site oxidizes the reducing end of cellobiose. ...
Phosphorylation of cellobiose with adenosine 5'-triphosphate by a -glucoside kinase". J. Biol. Chem. 247 (11): 3415-9. PMID ... The systematic name of this enzyme class is ATP:cellobiose 6-phosphotransferase. This enzyme is also called beta-D-glucoside ... In enzymology, a beta-glucoside kinase (EC 2.7.1.85) is an enzyme that catalyzes the chemical reaction ATP + cellobiose ⇌ {\ ... the two substrates of this enzyme are ATP and cellobiose, whereas its two products are ADP and 6-phospho-beta-D-glucosyl-(1,4)- ...
Palmer RE, Anderson RL (1972). "Cellobiose metabolism in Aerobacter aerogenes. 3. Cleavage of cellobiose monophosphate by a ...
Henriksson G, Johansson G, Pettersson G (March 2000). "A critical review of cellobiose dehydrogenases". J. Biotechnol. 78 (2): ... EC 1.1.3.13 and cellobiose dehydrogenase EC 1.1.99.18 which share a number of regions of sequence similarities. They contain ...
C. lentocellum produces cellobiose 2-epimerase. Parte, A.C. "Cellulosilyticum". LPSN. "Cellulosilyticum lentocellum Taxon ...
"Induction of Cellulases in chaetomium cellulolyticumby cellobiose". Biotechnology and Bioengineering. 27 (9): 1389-91. doi: ...
The yeast can assimilate glucose, cellobiose, and salicin. Assimilation of sucrose and maltose is variable. It has a positive ...
"Cloning and analysis of Pycnoporus cinnabarinus cellobiose dehydrogenase". Gene. 234 (1): 23-33. doi:10.1016/S0378-1119(99) ...
doi:10.1016/S0007-1536(72)80067-6. Heale, J. B.; Gupta, D. P. (1970). "The Utilization of Cellobiose by Verticillium albo-atrum ... Heale, JB; Gupta, DP (1970). "The utilization of cellobiose by Verticillium albo-atrum". Journal of General Microbiology. UK: ...
... resulting in cellobiose. At the end of both processes, Beta-glucosidases further catabolize cellobiose into glucose. Another ... Products from the cleavage are glucose and cellobiose. Another method involves endoglucanases hydrolyzing cellulose at random ... Cellobiohydrolase 1 from Trichoderma reesei Degrades Cellulose in Single Cellobiose Steps. Nature Communications 6, 10149 (2015 ...
In this cell-free biosystem, beta-1,4-glycosidic bond-linked cellulose is partially hydrolyzed to cellobiose. Cellobiose ...
When predating on nematodes, the fungus uses cellobiose, L-asparagine, L-arginine, DL glutamic acid for its carbon and nitrogen ... Saprophytic growth uses D-xylose, D-mannose, and cellobiose. The fungus uses nitrite, nitrate, and ammonium for its nitrogen ...
Cellobiose lipids are known as biosurfactants and natural detergents. They can be used in pharmaceutical, cosmetic, and food ... The acid is a cellobiose lipid produced by the corn smut fungus Ustilago maydis under conditions of nitrogen starvation. The ... Similar compounds are the extracellular cellobiose lipids of the yeasts Cryptococcus humicola and Trichosporon porosum : 2,3,4- ...
The yeast can assimilate glucose, sucrose, cellobiose, and salicin. Assimilation of glycerol is variable. It has a positive ...
The yeast can assimilate glucose, sucrose, cellobiose, arbutin, and salicin. It has a positive growth rate at 30°C, but there ... The yeast can ferment glucose and can weakly ferment sucrose, but not galactose, cellobiose, maltose, or lactose. ...
nov., moderately thermophilic, cellulose-/cellobiose-digesting bacteria isolated from methanogenic sludge". International ...
nov., moderately thermophilic, cellulose-/cellobiose-digesting bacteria isolated from methanogenic sludge". International ...
investigated use of cellobiose phosphorylase (CP) toward synthesis of alpha-glycosides in ionic liquids. The best condition for ... "Chemoenzymatic Synthesis of β-D Glucosides using Cellobiose Phosphorylase from Clostridium thermocellum". Advanced Synthesis & ...
Ért.) "Verhalten der Cellobiose u. ihres Osons gegen einige Enzyme" (with Emil Fischer; Berlin, 1909-10; Liebig's Annalen, and ... "Einige Derivate der Cellobiose" (with Emil Fischer; Budapest, 1911; Berichte der deutschen Chemischen Gesellschaft) "Studien ...
Oxidative cellulases depolymerize cellulose by radical reactions, as for instance cellobiose dehydrogenase (acceptor). ... such as cellobiose. Exocellulases are further classified into type I, that work processively from the reducing end of the ...
Cellulose may be further hydrolyzed to cellobiose or glucose in an acidic medium. Humans cannot digest cellulose and excrete ...
They ferment D-glucose and also ferment D-mannitol, L-rhamnose and cellobiose. They are negative for indole production, urea ...
The former can transport aromatic β-glucosides and cellobiose, as well as Chb. However, only Chb induces expression of the chb ...
equuli is not capable of fermenting cellobiose, whereas the opposite is true for A. equuli subsp. haemolyticus, indicated by a ... negative and positive result for the cellobiose fermentation test, respectively. However, both subspecies are positive for ...
negative for F7 Melibiose, F8 Lactose, F9 Cellobiose, F11 Raffinose, F12 Inulin, F14 D-xylose. negative delay after 7 days for ...
BglB is the main β-glucosidase gene transcribed when cells are grown in glucose or cellobiose cultures. BglA is only ... Additionally, adding degrading cellodextrins in the periplasm could increase efficiency by reducing loss of cellobiose to ... turning cellobiose (a disaccharide) into glucose. β-glucosidases belong to GH3, another glycoside hydrolase family. C. ... cells are unable to degrade cellobiose. Unlike other β-glucosidases, BglA's hydrolytic activity does not decrease with longer ...
Maltose, cellobiose, and chitobiose are hydrolysis products of the polysaccharides starch, cellulose, and chitin, respectively ... maltose and cellobiose are examples of reducing disaccharides, each with one hemiacetal unit, the other occupied by the ...
"Human Metabolome Database: Showing metabocard for Cellobiose (HMDB0000055)". Braun, G. (1943). "α-Cellobiose Octaacetate" (PDF ... Cellobiose is a disaccharide with the formula (C6H7(OH)4O)2O. It is classified as a reducing sugar. In terms of its chemical ... Cellobiose has eight free alcohol (OH) groups, one acetal linkage and one hemiacetal linkage, which give rise to strong inter- ... Cellobiose can be used as an indicator carbohydrate for Crohns disease and malabsorption syndrome. Treatment of cellulose with ...
This page contains information on the chemical Cellobiose including: 38 synonyms/identifiers. ... Cellobiose*Cellobiose (8CI) *Cellobiose, .beta.-*Cellose*CTR*D-(+)-Cellobiose*D-Cellobiose*D-Glucopyranose, 4-O-beta-D- ... Cellobiose. Identifications. *CAS Number: 528-50-7*Synonyms/Related:*.beta.-Cellobiose*.beta.-D-Glucopyranose, 4-O-.beta.-D- ... Cellobiose (EnvironmentalChemistry.com),/a,- This page contains information on the chemical Cellobiose including: 38 synonyms/ ...
Cellobiose Phosphorylase (Cellulomonas gilvus). Find diseases associated with this biological target and compounds tested ...
The X-ray crystal structure of a thermophilic cellobiose binding protein bound with cellobiose ... T. maritima cellobiose-binding protein binds a variety of lengths of beta(14)-linked glucose oligomers, ranging from two ... Here, we present the crystal structure of a T. maritima cellobiose-binding protein (tm0031) that is homologous to oligopeptide- ... The X-ray crystal structure of a thermophilic cellobiose binding protein bound with cellobiose. *PDB DOI: https://doi.org/ ...
... domains of the enzyme cellobiose dehydrogenase (CDH) isolated from the fungi Neurospora crassa, Corynascus thermophilus, and ... Determination of the Distance Between the Cytochrome and Dehydrogenase Domains of Immobilized Cellobiose Dehydrogenase by Using ... domains of the enzyme cellobiose dehydrogenase (CDH) isolated from the fungi Neurospora crassa, Corynascus thermophilus, and ...
keywords = "Cellobiose, Cellodextrin transporter, Co-utilization, Cofactor regeneration, Xylitol",. author = "Oh, {Eun Joong} ... The D-10-BT strain exhibited 40% higher volumetric xylitol productivity with co-consumption of cellobiose and xylose compared ... These results suggest that co-utilization of cellobiose and xylose can lead to improved xylitol production through enhanced ... Dive into the research topics of Enhanced xylitol production through simultaneous co-utilization of cellobiose and xylose by ...
Cellobiose analytical standard; CAS Number: 528-50-7; EC Number: 208-436-5; Synonyms: β-D-Glc-(1→4)-D-Glc,4-O-β-D- ... D-(+)-Cellobiose may be used as an analytical standard in the following:. *Training, testing, and external validation of the ... D-(+)-Cellobiose may be used as an analytical reference standard for the quantification of the analyte in caramel samples using ... Cellobiose is a disaccharide, commonly classified as a reducing sugar. It is mostly produced as an intermediate in the ...
Cellobiose. Description. Cellobiose, also known as GLCB1-4GLCB or cellose, belongs to the class of organic compounds known as o ... Cellobiose is also a microbe metabolite. Cellobiose is an extremely weak basic (essentially neutral) compound (based on its pKa ... Cellobiose exists in all living species, ranging from bacteria to humans. Outside of the human body, Cellobiose has been ... This could make cellobiose a potential biomarker for the consumption of these foods. This carbohydrate is exogenous and is a ...
... and diminished recognition for cellobiose (a beta-glucoside). Nine mutants were isolated from a strain encoding a wild-type ... and diminished recognition for cellobiose (a beta-glucoside). Nine mutants were isolated from a strain encoding a wild-type ... and diminished recognition for cellobiose (a beta-glucoside). Nine mutants were isolated from a strain encoding a wild-type ... and diminished recognition for cellobiose (a beta-glucoside). Nine mutants were isolated from a strain encoding a wild-type ...
Nyanhongo, G. S., Flitsch, A., Precilus, S., & Gübitz, G. (2011). Antimicrobial and bleaching systems based on cellobiose ... Nyanhongo, GS, Flitsch, A, Precilus, S & Gübitz, G 2011, Antimicrobial and bleaching systems based on cellobiose dehydrogenase ... Antimicrobial and bleaching systems based on cellobiose dehydrogenase. Gibson Stephen Nyanhongo, Annemarie Flitsch, Sina ... Antimicrobial and bleaching systems based on cellobiose dehydrogenase. / Nyanhongo, Gibson Stephen; Flitsch, Annemarie; ...
... Organism: Streptomyces coelicolor J846. ...
A chemical interaction between cellobiose and the resin (e.g. grafting of siloxane fragments onto the cellobiose) was ... Investigation of the pyrolysis mechanisms of cellobiose in the presence of a polysiloxane. ... an investigation of the pyrolysis mechanisms was performed on a model system based on cellobiose and a polysiloxane resin. ...
Impairment of cellulose- and cellobiose-degrading soil Bacteria by two acidic herbicides. In: FEMS Microbiology Letters. Vol. ... Microbial processes (e.g. fermentations, ferric iron reduction) that were linked to anaerobic cellulose, and cellobiose ... Impairment of cellulose- and cellobiose-degrading soil Bacteria by two acidic herbicides ... addressed the toxic effect of Bentazon and MCPA on aerobic and anaerobic Bacteria that are involved in cellulose and cellobiose ...
Zhang J, Liu X, Hedhili MN, Zhu Y, Han Y. Highly Selective and Complete Conversion of Cellobiose to Gluconic Acid over Au/ ... Zhang, J, Liu, X, Hedhili, MN, Zhu, Y & Han, Y 2011, Highly Selective and Complete Conversion of Cellobiose to Gluconic Acid ... Zhang, J., Liu, X., Hedhili, M. N., Zhu, Y., & Han, Y. (2011). Highly Selective and Complete Conversion of Cellobiose to ... Highly Selective and Complete Conversion of Cellobiose to Gluconic Acid over Au/Cs2HPW12O40 Nanocomposite Catalyst. In: ...
The aim of my work was the research of a photocatalyst for the hydrolysis of cellobiose under visible irradiation. Cellobiose ... The aim of my work was the research of a photocatalyst for the hydrolysis of cellobiose under visible irradiation. Cellobiose ... Lombardi, Erica (2013) Selective photo-oxidation of cellobiose with tio2-supported metal nanoparticles. [Laurea magistrale], ...
Cellobiose dehydrogenase catalyzes the oxidation of various carbohydrates and is considered as a possible anode catalyst in ... Spectroscopic Observation of Calcium-Induced Reorientation of Cellobiose Dehydrogenase Immobilized on Electrodes and its Effect ...
A Non-Linear Deterministic Model for Regulation of Diauxic Lag on Cellobiose by the Pneumococcal Multidomain Transcriptional ... 2012). A Non-Linear Deterministic Model for Regulation of Diauxic Lag on Cellobiose by the Pneumococcal Multidomain ... 2012). A Non-Linear Deterministic Model for Regulation of Diauxic Lag on Cellobiose by the Pneumococcal Multidomain ... not able to support growth on cellobiose, is responsible for the lag during diauxic growth. A mathematical model of the process ...
Cellobiose. glucose. glucose. β(1→4). cellobiase Maltose and cellobiose are hydrolysis products of the polysaccharides, starch ... Even maltose and cellobiose, which are made up of two covalently bonded glucose units, differ due to the nature of the linkage ... Although maltose and cellobiose are disaccharide isomers, both having the formula C12H22O11, they are different compounds with ... While the disaccharides sucrose, lactose, maltose, and cellobiose have the same chemical formula, C12H22O11, and all have at ...
RESOLUTION AND ASSIGNMENT OF THE 270-MHZ PROTON SPECTRUM OF CELLOBIOSE BY HOMO-NUCLEAR AND HETERONUCLEAR TWO-DIMENSIONAL NMR. ... RESOLUTION AND ASSIGNMENT OF THE 270-MHZ PROTON SPECTRUM OF CELLOBIOSE BY HOMO-NUCLEAR AND HETERONUCLEAR TWO-DIMENSIONAL NMR. ...
Engineering Pseudomonas putida for co-utilization of cellobiose with glucose BUJDOŠ Dalimil BŘENKOVÁ Barbora SONNENSCHEIN ...
... and cellobiose oxidase [49, 50]. During oxidation of cellobiose both enzymes reduce quinones to the corresponding phenols. ... Cellobiose oxidase also reduces Fe(III), together with hydrogen peroxide which is also produced by this enzyme, thus forming a ... CBHII inverts the configuration at the glycosidic bond, so that the first-formed cellobiose is the α-anomer [34]. Taking the ... Reese in 1957 speculated on the existence of an esterase, active on cellobiose octaacetate [9]. A cellulose acetate- ...
Cellobiose. Positive (+ve). Dulcitol. Negative (-ve). Glucose. Positive (+ve). Glycerol. Variable. Lactose. Negative (-ve). ...
Cellobiose, glucose, xylose, mannose, galactose, and arabinose were used as standards. Although this column elutes xylose, ...
Title: Roles of starting geometries in quantum mechanics studies of cellobiose Author. French, Alfred - Al ... The probabilities of the various overall shapes of cellobiose depended on the orientations of the hydroxyl and primary alcohol ... Roles of starting geometries in quantum mechanics studies of cellobiose. Molecular Simulation.Vol. 34, No. 4, April 2008, 365- ... was used to predict the probabilities of the various shapes of cellobiose, the shortest prototype of the main molecule in ...
See formulation under modified cellobiose-polymyxin B-colistin (mCPC) agar (M98).. Original Source: Bacteriological Analytical ...
... cellobiose, .alpha.-D-Cellobiose octaacetate, D-(+)-Cellobiose octaacetate, NSC1221, NSC1351, NSC1690, NSC1696, NSC1956, ... Cellobiose, octaacetate, .alpha.-, .BETA.-LACTOSE, OCTAACETATE, CID140906, Cellobiose, octaacetate, .alpha.-D-, .beta.-D- ... Alpha-D-Cellobiose Octaacetate (33 suppliers). IUPAC Name: [2,3-diacetyloxy-6-(acetyloxymethyl)-5-[3,4,5-triacetyloxy-6-( ... Synonyms: Cyclooctaamylose, Maltose octaacetate, D-Cellobiose octaacetate, .beta.-Maltose octaacetate, Maltose, octaacetate, . ...
Used in assay of streptomycin, and streptothricins.
  • Treatment of cellulose with acetic anhydride and sulfuric acid gives cellobiose octoacetate, which is no longer a hydrogen bond donor (though it is still a hydrogen bond acceptor) and is soluble in nonpolar organic solvents. (wikipedia.org)
  • Obtained from the partial hydrolysis of cellulose, cellobiose is commonly used as an indicator carbohydrate for intestinal permeability in Crohn's disease and malabsorption syndrome. (lmdb.ca)
  • The current study addressed the toxic effect of Bentazon and MCPA on aerobic and anaerobic Bacteria that are involved in cellulose and cellobiose degradation in an agricultural soil. (uni-bayreuth.de)
  • Microbial processes (e.g. fermentations, ferric iron reduction) that were linked to anaerobic cellulose, and cellobiose degradation were reduced in the presence of both herbicides at concentrations above and at those that occur in crop field soil. (uni-bayreuth.de)
  • Collectively, the results suggested that the metabolism of anaerobic cellulose-degrading Bacteria were impaired by in situ-typical herbicide concentrations, whereas in situ concentrations did not impair metabolism of aerobic cellulose- and cellobiose-degrading soil Bacteria. (uni-bayreuth.de)
  • In this work, electronic structure theory, also called quantum mechanics, was used to predict the probabilities of the various shapes of cellobiose, the shortest prototype of the main molecule in cotton, cellulose. (usda.gov)
  • formerly known as cellulase family C. The cellobiohydrolases of this family act processively from the reducing ends of cellulose chains to generate cellobiose. (cazy.org)
  • The novel developed model was used for determining the mean distance between the cytochrome (CYT) and flavodehydrogenase (DH) domains of the enzyme cellobiose dehydrogenase (CDH) isolated from the fungi Neurospora crassa, Corynascus thermophilus, and Myriococcum thermophilum as a function of pH, [Ca2+], and substrate concentration. (chalmers.se)
  • Cellobiose dehydrogenase catalyzes the oxidation of various carbohydrates and is considered as a possible anode catalyst in biofuel cells. (istanbul.edu.tr)
  • 2014. Mediatorless Carbohydrate/Oxygen Biofuel Cells with Improved Cellobiose Dehydrogenase Based Bioanode. (bchi.lt)
  • Isolation and characterization of lactose permease mutants with an enhanced recognition of maltose and diminished recognition of cellobiose. (umn.edu)
  • In the present study, lactose permease mutants were isolated which have an enhanced recognition toward maltose (an alpha-glucoside) and diminished recognition for cellobiose (a beta-glucoside). (umn.edu)
  • All 18 mutants exhibited enhanced recognition for maltose (compared with the pTE18 strain) and a diminished recognition for cellobiose. (umn.edu)
  • Dive into the research topics of 'Isolation and characterization of lactose permease mutants with an enhanced recognition of maltose and diminished recognition of cellobiose. (umn.edu)
  • While the disaccharides sucrose, lactose, maltose, and cellobiose have the same chemical formula, C 12 H 22 O 11 , and all have at least one glucose molecule as part of their structure, they differ substantially in their properties. (newworldencyclopedia.org)
  • Even maltose and cellobiose, which are made up of two covalently bonded glucose units, differ due to the nature of the linkage, with maltose easily hydrolyzed to its monosaccharides in the human body whereas cellobiose cannot be digested. (newworldencyclopedia.org)
  • The aim of my work was the research of a photocatalyst for the hydrolysis of cellobiose under visible irradiation. (unibo.it)
  • The enzyme was active toward the substrates salicin (495.0 ± 49.0 U mg-1), pNPG (340.5 ± 18.6 U mg-1), cellobiose (89.3 ± 5.1 U mg-1), and lactose (45.1 ± 0.5 U mg-1), so it had broad specificity. (bvsalud.org)
  • Cellobiose, also known as GLCB1-4GLCB or cellose, belongs to the class of organic compounds known as o-glycosyl compounds. (lmdb.ca)
  • Cellobiose is a disaccharide with the formula (C6H7(OH)4O)2O. (wikipedia.org)
  • Cellobiose is a disaccharide, commonly classified as a reducing sugar. (sigmaaldrich.com)
  • Solopova tested how well cells that are adapted to cellobiose respond to a subsequent switch to galactose. (rug.nl)
  • The probabilities of the various overall shapes of cellobiose depended on the orientations of the hydroxyl and primary alcohol groups that are part of the two glucose units that compose cellobiose. (usda.gov)
  • The D-10-BT strain exhibited 40% higher volumetric xylitol productivity with co-consumption of cellobiose and xylose compared to sequential utilization of glucose and xylose. (illinois.edu)
  • The experimental results and the related insights provided by the mathematical model provide evidence that the conflicting activation of the CelR regulator is at the origin of the lag phase during sequential growth on glucose and cellobiose. (unisi.it)
  • Cellobiose exists in all living species, ranging from bacteria to humans. (lmdb.ca)
  • What happens is not that the bacteria switch from one system to another, but that a small group of cells which are prepared to use cellobiose begin to dominate the population', Kuipers explains. (rug.nl)
  • Cellobiose can be used as an indicator carbohydrate for Crohn's disease and malabsorption syndrome. (wikipedia.org)
  • Recent studies have shown that cellobiose can be processed or metabolized by endogenous beta glycosidases in the mammalian small intestine (PMID 18752931 ). (lmdb.ca)
  • Cellobiose was selected because it is a model molecule for biomass depolymerisation studies. (unibo.it)
  • Solopova used fluorescent labels to make the cells that use the new sugar source (in her case cellobiose ) stand out. (rug.nl)
  • She used this setup to investigate how cells respond to the switch from glucose to cellobiose. (rug.nl)
  • In each division, the two daughter cells will inherit part of the cell membrane and proteins from the 'mother' cell, and these will contain cellobiose transporters if the cells were grown on this sugar source. (rug.nl)
  • Cellobiose is an extremely weak basic (essentially neutral) compound (based on its pKa). (lmdb.ca)
  • This could make cellobiose a potential biomarker for the consumption of these foods. (lmdb.ca)
  • Furthermore, the overexpression of S. cerevisiae ALD6, IDP2, or S. stipitis ZWF1 coding for cytosolic NADP + -dependent dehydrogenases increased the intracellular NADPH availability of the D-10-BT strain, which resulted in a 37-63% improvement in xylitol productivity when cellobiose and xylose were co-consumed. (illinois.edu)
  • Analysis of mutants for other PTS systems indicates that a second beta-glucoside PTS (spr0505), not able to support growth on cellobiose, is responsible for the lag during diauxic growth. (unisi.it)
  • Here, we present the crystal structure of a T. maritima cellobiose-binding protein (tm0031) that is homologous to oligopeptide-binding proteins. (rcsb.org)
  • T. maritima cellobiose-binding protein binds a variety of lengths of beta(1-->4)-linked glucose oligomers, ranging from two rings (cellobiose) to five (cellopentaose). (rcsb.org)
  • They probably don't have enough energy to make the switch to using cellobiose', says Kuipers. (rug.nl)
  • To account for the beneficial effect of the polysiloxane, an investigation of the pyrolysis mechanisms was performed on a model system based on cellobiose and a polysiloxane resin. (oskar-bordeaux.fr)
  • Furthermore, S. cerevisiae expression of Fusion 3 construct was poor and only minimal activity was observed when acting on the substrate, p NP-cellobiose. (biomedcentral.com)
  • AfBgl1.3 displayed transglycosylation activity, forming cellotriose from cellobiose. (bvsalud.org)
  • If they are grown on cellobiose before the experiment in which they must switch from glucose to cellobiose, the lag phase is shorter. (rug.nl)
  • Kuipers: 'In this case, there are still some cellobiose transporters present in the membranes of the cell. (rug.nl)