Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Transplantation of an individual's own tissue from one site to another site.
The transference of a part of or an entire liver from one human or animal to another.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
The transference of a kidney from one human or animal to another.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
The transference of a heart from one human or animal to another.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
The transference of either one or both of the lungs from one human or animal to another.
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Transference of an organ between individuals of the same species or between individuals of different species.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
The return of a sign, symptom, or disease after a remission.
The transference of a pancreas from one human or animal to another.
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Elements of limited time intervals, contributing to particular results or situations.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Immunological rejection of leukemia cells following bone marrow transplantation.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Immunological rejection of tumor tissue/cells following bone marrow transplantation.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Providers of tissues for transplant to non-related individuals.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS. Extracellular matrix, rich in FIBRONECTINS, is usually deposited around the HEPATIC VEINS leading to venous outflow occlusion and sinusoidal obstruction.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
Transference of fetal tissue between individuals of the same species or between individuals of different species.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
The transfer of lymphocytes from a donor to a recipient or reinfusion to the donor.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
Disorders of the blood and blood forming tissues.
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
Transplantation between animals of different species.
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
Disease having a short and relatively severe course.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.
Progenitor cells from which all blood cells derive.
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
The number of births in a given population per year or other unit of time.
Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.
Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
Partial or total replacement of the CORNEA from one human or animal to another.
Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
Prospective patient listings for appointments or treatments.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).
Pathological processes of the LIVER.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Disorders characterized by proliferation of lymphoid tissue, general or unspecified.
Allelic alloantigens often responsible for weak graft rejection in cases when (major) histocompatibility has been established by standard tests. In the mouse they are coded by more than 500 genes at up to 30 minor histocompatibility loci. The most well-known minor histocompatibility antigen in mammals is the H-Y antigen.
Remnant of a tumor or cancer after primary, potentially curative therapy. (Dr. Daniel Masys, written communication)
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
The preparation of leukocyte concentrates with the return of red cells and leukocyte-poor plasma to the donor.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A dead body, usually a human body.
Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.
The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.
Tissues, cells, or organs transplanted between genetically different individuals of the same species.
A general term for various neoplastic diseases of the lymphoid tissue.
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
Substances that inhibit or prevent the proliferation of NEOPLASMS.
The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Antibodies produced by a single clone of cells.
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.
The physiological renewal, repair, or replacement of tissue.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
The transfer of leukocytes from a donor to a recipient or reinfusion to the donor.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Antibodies obtained from a single clone of cells grown in mice or rats.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Infection with ROSEOLOVIRUS, the most common in humans being EXANTHEMA SUBITUM, a benign disease of infants and young children.
Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
Therapies that involve the TRANSPLANTATION of CELLS or TISSUES developed for the purpose of restoring the function of diseased or dysfunctional cells or tissues.
An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
The number of LYMPHOCYTES per unit volume of BLOOD.
Any procedure in which blood is withdrawn from a donor, a portion is separated and retained and the remainder is returned to the donor.
Euploid male germ cells of an early stage of SPERMATOGENESIS, derived from prespermatogonia. With the onset of puberty, spermatogonia at the basement membrane of the seminiferous tubule proliferate by mitotic then meiotic divisions and give rise to the haploid SPERMATOCYTES.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Cells derived from a FETUS that retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
A family composed of spouses and their children.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
Immunoglobulins induced by antigens specific for tumors other than the normally occurring HISTOCOMPATIBILITY ANTIGENS.
A PREDNISOLONE derivative with similar anti-inflammatory action.
The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.
An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.
An individual that contains cell populations derived from different zygotes.
The transference of a complete HAND, as a composite of many tissue types, from one individual to another.
Infections with fungi of the genus ASPERGILLUS.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Methods for maintaining or growing CELLS in vitro.
The period following a surgical operation.
A mutant strain of Rattus norvegicus without a thymus and with depressed or absent T-cell function. This strain of rats may have a small amount of hair at times, but then lose it.
The cells found in the body fluid circulating throughout the CARDIOVASCULAR SYSTEM.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The number of PLATELETS per unit volume in a sample of venous BLOOD.
The immune responses of a host to a graft. A specific response is GRAFT REJECTION.
Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.

oko meduzy mutations affect neuronal patterning in the zebrafish retina and reveal cell-cell interactions of the retinal neuroepithelial sheet. (1/1372)

Mutations of the oko meduzy (ome) locus cause drastic neuronal patterning defect in the zebrafish retina. The precise, stratified appearance of the wild-type retina is absent in the mutants. Despite the lack of lamination, at least seven retinal cell types differentiate in oko meduzy. The ome phenotype is already expressed in the retinal neuroepithelium affecting morphology of the neuroepithelial cells. Our experiments indicate that previously unknown cell-cell interactions are involved in development of the retinal neuroepithelial sheet. In genetically mosaic animals, cell-cell interactions are sufficient to rescue the phenotype of oko meduzy retinal neuroepithelial cells. These cell-cell interactions may play a critical role in the patterning events that lead to differentiation of distinct neuronal laminae in the vertebrate retina.  (+info)

Adult subventricular zone neuronal precursors continue to proliferate and migrate in the absence of the olfactory bulb. (2/1372)

Neurons continue to be born in the subventricular zone (SVZ) of the lateral ventricles of adult mice. These cells migrate as a network of chains through the SVZ and the rostral migratory stream (RMS) into the olfactory bulb (OB), where they differentiate into mature neurons. The OB is the only known target for these neuronal precursors. Here, we show that, after elimination of the OB, the SVZ and RMS persist and become dramatically larger. The proportion of dividing [bromodeoxyuridine (BrdU)-labeled] or dying (pyknotic or terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end-labeled) cells in the RMS was not significantly affected at 3 d or 3 weeks after bulbectomy (OBX). However, by 3 months after OBX, the percentage of BrdU-labeled cells in the RMS decreased by half and that of dying cells doubled. Surprisingly, the rostral migration of precursors continued along the RMS after OBX. This was demonstrated by focal microinjections of BrdU and grafts of SVZ cells carrying LacZ under the control of a neuron-specific promoter gene. Results indicate that the OB is not essential for proliferation and the directional migration of SVZ precursors.  (+info)

Endothelial implants inhibit intimal hyperplasia after porcine angioplasty. (3/1372)

The perivascular implantation of tissue-engineered endothelial cells around injured arteries offers an opportunity to study fundamental vascular physiology as well as restore and improve tissue function. Cell source is an important issue because the ability to implant either xenogeneic or allogeneic cells would greatly enhance the clinical applications of tissue-engineered grafts. We investigated the biological and immunological responses to endothelial cell xenografts and allografts in pigs 4 weeks after angioplasty of the carotid arteries. Porcine or bovine aortic endothelial cells were cultured within Gelfoam matrices and implanted in the perivascular space of 42 injured arteries. Both porcine and bovine endothelial cell grafts reduced the restenosis index compared with control by 54% and 46%, respectively. Perivascular heparin release devices, formulated to release heparin at twice the rate of release of heparan sulfate proteoglycan from endothelial cell implants, produced no significant reduction in the restenosis index. Endothelial cell implants also reduced occlusive thrombosis compared with control and heparin release devices. Host immune responses to endothelial implants were investigated by immunohistochemical examination of explanted devices and by immunocytochemistry of serum samples. The bovine cell grafts displayed infiltration of leukocytes, consisting primarily of lymphocytes, and caused an increase in antibodies detected in serum samples. Reduced cellular infiltration and no humoral response were detected in animals that received allografts. Despite the difference in immune response, the biological effects of xenografts or allografts did not differ significantly.  (+info)

Repopulation of different layers of host human Bruch's membrane by retinal pigment epithelial cell grafts. (4/1372)

PURPOSE: To determine the morphology of human retinal pigment epithelium (RPE) after reattachment to different ultrastructural layers of human Bruch's membrane (BM). METHODS: Bruch's membrane explants were prepared from eyes of 23 human donors (age range, 11-89 years). The basal lamina of the RPE, inner collagenous layer, and elastin layer were removed sequentially by mechanical and enzymatic techniques. First-passage cells of human RPE (15,000 cells/6 mm explant) from three donors (ages, 52, 64, and 80 years) were plated onto different layers of human BM, and the explants were examined by scanning and transmission electron microscopy up to 21 days later. RESULTS: RPE flattened and extended footplates 6 hours after plating onto basal lamina. Cells remained round 6 and 24 hours after plating onto the inner collagenous, elastin, or outer collagenous layer. The RPE cells became confluent 14 days after plating onto basal lamina but did not become confluent up to 21 days after plating onto the inner collagenous or elastin layer. Sparse round cells were observed 21 days after plating onto deeper layers, suggesting extensive loss of RPE. CONCLUSIONS: The morphology and subsequent behavior of the RPE reattached to BM depends on the anatomic layer of BM available for cell reattachment. The results suggest that the ability of transplanted RPE to repopulate BM in age-related macular degeneration and other disorders may depend on the layer of BM available to serve as a substrate for cell reattachment.  (+info)

Transplantation of osteoblast-like cells to the distracted callus in rabbits. (5/1372)

We carried out limb lengthening in rabbits and then transplanted osteoblast-like cells derived from the tibial periosteum to the centres of distracted callus immediately after distraction had been terminated. Two weeks later the transaxial area ratio at the centre of the distracted callus and the bone mineral density (BMD) were significantly higher in the transplanted group, by 21% and 42%, respectively, than in the non-injected group or the group injected with physiological saline (p < 0.05). Callus BMD as a percentage of density in uninvolved bone was also significantly higher in the transplanted group (p < 0.05) than in the other two groups, by 27% and 20% in the second and fourth weeks, respectively (p < 0.05). Mechanically, the callus in the transplanted group tended to be stronger as shown by the three-point bending test although the difference in fracture strength was not statistically significant. Our results show that transplantation of osteoblast-like cells promotes maturity of the distracted callus as observed at the second and fourth weeks after lengthening. The method appears promising as a means of shortening the consolidation period of callus distraction and decreasing complications during limb lengthening with an external fixator.  (+info)

Transplanted hepatocytes proliferate differently after CCl4 treatment and hepatocyte growth factor infusion. (6/1372)

To understand regulation of transplanted hepatocyte proliferation in the normal liver, we used genetically marked rat or mouse cells. Hosts were subjected to liver injury by carbon tetrachloride (CCl4), to liver regeneration by a two-thirds partial hepatectomy, and to hepatocellular DNA synthesis by infusion of hepatocyte growth factor for comparative analysis. Transplanted hepatocytes were documented to integrate in periportal areas of the liver. In response to CCl4 treatments after cell transplantation, the transplanted hepatocyte mass increased incrementally, with the kinetics and magnitude of DNA synthesis being similar to those of host hepatocytes. In contrast, when cells were transplanted 24 h after CCl4 administration, transplanted hepatocytes appeared to be injured and most cells were rapidly cleared. When hepatocyte growth factor was infused into the portal circulation either subsequent to or before cell transplantation and engraftment, transplanted cell mass did not increase, although DNA synthesis rates increased in cultured primary hepatocytes as well as in intact mouse and rat livers. These data suggested that procedures causing selective ablation of host hepatocytes will be most effective in inducing transplanted cell proliferation in the normal liver. The number of transplanted hepatocytes was not increased in the liver by hepatocyte growth factor administration. Repopulation of the liver with genetically marked hepatocytes can provide effective reporters for studying liver growth control in the intact animal.  (+info)

Dynamics of myoblast transplantation reveal a discrete minority of precursors with stem cell-like properties as the myogenic source. (7/1372)

Myoblasts, the precursors of skeletal muscle fibers, can be induced to withdraw from the cell cycle and differentiate in vitro. Recent studies have also identified undifferentiated subpopulations that can self-renew and generate myogenic cells (Baroffio, A., M. Hamann, L. Bernheim, M.-L. Bochaton-Pillat, G. Gabbiani, and C.R. Bader. 1996. Differentiation. 60:47-57; Yoshida, N., S. Yoshida, K. Koishi, K. Masuda, and Y. Nabeshima. 1998. J. Cell Sci. 111:769-779). Cultured myoblasts can also differentiate and contribute to repair and new muscle formation in vivo, a capacity exploited in attempts to develop myoblast transplantation (MT) for genetic modification of adult muscle. Our studies of the dynamics of MT demonstrate that cultures of myoblasts contain distinct subpopulations defined by their behavior in vitro and divergent responses to grafting. By comparing a genomic and a semiconserved marker, we have followed the fate of myoblasts transplanted into muscles of dystrophic mice, finding that the majority of the grafted cells quickly die and only a minority are responsible for new muscle formation. This minority is behaviorally distinct, slowly dividing in tissue culture, but rapidly proliferative after grafting, suggesting a subpopulation with stem cell-like characteristics.  (+info)

Hepatocyte gene therapy in a large animal: a neonatal bovine model of citrullinemia. (8/1372)

The development of gene-replacement therapy for inborn errors of metabolism has been hindered by the limited number of suitable large-animal models of these diseases and by inadequate methods of assessing the efficacy of treatment. Such methods should provide sensitive detection of expression in vivo and should be unaffected by concurrent pharmacologic and dietary regimens. We present the results of studies in a neonatal bovine model of citrullinemia, an inborn error of urea-cycle metabolism characterized by deficiency of argininosuccinate synthetase and consequent life-threatening hyperammonemia. Measurements of the flux of nitrogen from orally administered 15NH4 to [15N]urea were used to determine urea-cycle activity in vivo. In control animals, these isotopic measurements proved to be unaffected by pharmacologic treatments. Systemic administration of a first-generation E1-deleted adenoviral vector expressing human argininosuccinate synthetase resulted in transduction of hepatocytes and partial correction of the enzyme defect. The isotopic method showed significant restoration of urea synthesis. Moreover, the calves showed clinical improvement and normalization of plasma glutamine levels after treatment. The results show the clinical efficacy of treating a large-animal model of an inborn error of hepatocyte metabolism in conjunction with a method for sensitively measuring correction in vivo. These studies will be applicable to human trials of the treatment of this disorder and other related urea-cycle disorders.  (+info)

Shoukang Zhu, Shanming Deng, Qi Ma, Taifang Zhang, Chunling Jia, Degen Zhuo, Falin Yang, Jianqin Wei, Liyong Wang, Derek M. Dykxhoorn, Joshua M. Hare, Pascal J. Goldschmidt-Clermont and Chunming Dong ...
A primary assumption that guides current approaches to in utero hematopoietic cellular transplantation (IUHCT) is that the early-gestation fetus has an immature...
Cellular therapy is a therapy in which cellular material is inserted into a patient, its means intact, living cells. The main motto of cell therapy is to introduce cells into the body that will grow and replace damaged tissue. Organs and glands are used in cell treatment include brain, pituitary, thyroid, heart, pancreas, adrenals, thymus, liver, kidney, spleen, ovary and testis ...
Nashville Tennessee Endothelial cell transplantation to treat Fuchs Surgeon - Get all of your Endothelial cell transplantation to treat Fuchs Surgery questions answered at one of our Free laser vision correction seminars in Nashville, TN. Click here for more information!
PURPOSE. To evaluate the use of autologous serum (AS) from patients with severe ocular surface disease (OSD) in the development of transplantable corneal and oral epithelial tissue equivalents and to compare it with the use of conventional culture methods by using fetal bovine serum (FBS). METHODS. AS was obtained from patients with severe OSD secondary to Stevens-Johnson syndrome. Corneal and oral epithelial cells were cultivated in medium supplemented with either AS or FBS. Corneal and oral epithelial equivalents were constructed on denuded amniotic membranes. The bromodeoxyuridine (BrdU) ELISA cell proliferation assay and colony-forming efficiency (CFE) of cells cultivated in AS- or FBS-supplemented media were compared. The morphologic characteristics and the basement membrane assembly of cultivated epithelial equivalents were analyzed by light and electron microscopy, as well as by immunohistochemistry. RESULTS. BrdU proliferation assay and CFE analysis showed that human corneal and oral ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Skeletal muscle has tissue-specific stem cells named satellite cells. Satellite cells exist in a quiescent state between myofibers and the basal lamina. When skeletal muscle is injured, satellite cells are activated, proliferate, and differentiate into myofibers. It is reported that isolated satellite cells/myoblasts from healthy donors are able to fuse with host dystrophin-deficient myofibers after transplantation via intramuscular injection, and expression of dystrophin at the sarcolemma was observed. Therefore, myoblast transfer is expected to be a promising therapy for DMD. However, the numbers of cells prepared from donors are not adequate for clinical use. To obtain a large number of satellite cells/ myoblasts of good quality, we are developing a method to induce muscle stem cells from human iPS cells. Although autologous cell transplantation needs no immunosuppression, the genes require editing to express dystrophin. In addition, the time and expense required for the process impose a ...
Intramyocardial injections of cultured fetal cardiomyocytes after infarction in female rats in an ischaemia-reperfusion model increased ejection fraction at one month; male cells transplanted into the female hosts were identified at necropsy by detection of the Y chromosome using an in situ hybridisation technique.7 In a mouse model of doxorubicin induced global cardiomyopathy,8 local transplantation of fetal cardiomyocytes can also improve global function, suggesting the intervention of paracrine factors. Comparing intramyocardial injections of cultured fetal cardiomyocytes and allogenic fetal skeletal myoblasts after infarction in rats,9 the functional equivalence of these two types of cells was demonstrated with decreased cavity dilatation and increased ejection fraction of similar magnitude; this anti-remodelling effect was more pronounced for the lowest ejection fractions (, 40%) with an approximately 30% relative increase in ejection fraction without cavity dilatation. Similar results ...
Rajvanshi P, Fabrega A, Bhargava KK, Kerr A, Pollak R, Blanchard J, et al. Rapid clearance of transplanted hepatocytes from pulmonary capillaries in rats indicates a wide safety margin of liver repopulation and the potential of using surrogate albumin particles for safety analysis. J Hepatol 1999; 30: 299-310 ...
TY - CHAP. T1 - Hepatic preconditioning for transplanted cell engraftment and proliferation. AU - Wu, Yao Ming. AU - Gupta, Sanjeev. PY - 2009. Y1 - 2009. N2 - Hepatocyte transplantation has therapeutic potential for multiple hepatic and extrahepatic disorders with genetic or acquired basis. To demonstrate whether cell populations of interest will be effective for clinical applications, it is first necessary to characterize their properties in animal systems. Demonstrating the potential of cells to engraft and proliferate is a critical part of this characterization. Similarly, for stem/progenitor cells, demonstrating the capacity to differentiate along appropriate lineages and generate mature cells that can engraft and proliferate is essential. In various animal models, preconditioning of recipients prior to cell transplantation has been necessary to improve engraftment of cells, to stimulate proliferation of engrafted cells, and to induce extensive repopulation of the host liver by transplanted ...
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TY - JOUR. T1 - Differing phagocytic capacities of accessory and main olfactory ensheathing cells and the implication for olfactory glia transplantation therapies. AU - Nazareth, Lynnmaria. AU - Tello Velasquez, Johana. AU - Lineburg, Katie E.. AU - Chehrehasa, Fatemeh. AU - St John, James A.. AU - Ekberg, Jenny A K. PY - 2015/3/1. Y1 - 2015/3/1. N2 - The rodent olfactory systems comprise the main olfactory system for the detection of odours and the accessory olfactory system which detects pheromones. In both systems, olfactory axon fascicles are ensheathed by olfactory glia, termed olfactory ensheathing cells (OECs), which are crucial for the growth and maintenance of the olfactory nerve. The growth-promoting and phagocytic characteristics of OECs make them potential candidates for neural repair therapies such as transplantation to repair the injured spinal cord. However, transplanting mixed populations of glia with unknown properties may lead to variations in outcomes for neural repair. As the ...
Glaucoma is the term used to describe a group diseases characterised by a specific type of damage to the optic nerve head (ONH) known as cupping and a characteristic type of visual field loss. This loss is associated with progressive atrophy and loss of the retinal ganglion cells. Glaucoma is a leading cause of irreversible blindness in the world. This project was aimed at investigating olfactory ensheathing cells (OEC), a population of radial glia proven to be neuroprotective in central and peripheral nerve injury models, and their potential to protect the retinal ganglion cells in glaucoma. We studied the interactions of RGC and OEC in culture. We show that OEC can straighten, ensheath and bundle RGC neurites as well as support the survival of RGC and their synapses in culture. We also show that OEC endocytose dead RGC in culture. We modified a rat model of glaucoma (where paramagnetic microbeads are injected into the anterior chamber of the rat eyes) and characterised the early and late ...
TY - JOUR. T1 - Evidence for active acetylcholine metabolism in human amniotic epithelial cells. T2 - Applicable to intracerebral allografting for neurologic disease. AU - Sakuragawa, Norio. AU - Misawa, Hidemi. AU - Ohsugi, Keiko. AU - Kakishita, Kouji. AU - Ishii, Takashi. AU - Thangavel, Ramasamy. AU - Tohyama, Jun. AU - Elwan, Mohamed. AU - Yokoyama, Yasunobu. AU - Okuda, Osamu. AU - Arai, Hajime. AU - Ogino, Ikuko. AU - Sato, Kiyoshi. PY - 1997/8/22. Y1 - 1997/8/22. N2 - Human amniotic epithelial (HAE) cells have been used for allotransplantation in patients with lysosomal storage disease due to lack of expression of HLA antigens. Previously, we have reported the expression of differentiation markers for both neural stem cells, and neuron and glial cells. In the present study, we investigated the presence of choline acetyltransferase (CHAT) and acetylcholine (ACh) in HAE cells using different experimental approaches. Cultured HAE cells showed strong immunoreactivity against ChAT antibody. ...
Human Amniotic Epithelial Cell Lysate ...
Chen, H.-L., Chen, H.-L., Yuan, R.-H., Wu, S.-H., Chen, Y.-H., Chien, C.-S., Chou, S.-P., Wang, R., Ling, V. and Chang, M.-H. (2012), Hepatocyte transplantation in bile salt export pump-deficient mice: selective growth advantage of donor hepatocytes under bile acid stress. Journal of Cellular and Molecular Medicine, 16: 2679-2689. doi: 10.1111/j.1582-4934.2012.01586.x ...
The second day the conference focused on newer aspects of treatment for heart failure. Philippe Menasche (Paris) described the results of skeletal myoblast transfer in man. Based upon previous studies in animals, they had been able to optimise cell survival of thigh muscle myoblasts grown in culture. After 16 days culture a suspension containing 150 × 106 cells/ml is injected into scar tissue at the time of coronary artery bypass graft surgery (CABG). Although some 90% of these cells die early after transplantation, those that survive remain committed to skeletal muscle form, but are resistant to ischaemia. To date, there is no evidence that skeletal myoblast transplantation leads to the formation of connexin 43 junctions, but arrhythmias remain a potential complication. Nevertheless, initial results in eight patients have shown evidence of improved cardiac function. A trial is proposed which will compare CABG grafting and injection of medium with CABG surgery and transplanted cells in 70-75 ...
Sigma-Aldrich offers abstracts and full-text articles by [Ali Jahed, James W Rowland, Todd McDonald, J Gordon Boyd, Ronald Doucette, Michael D Kawaja].
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Until their disease starts to quiet down. Could be a little challenging. I was trying to make a few incisions here to see if there was another layer interface. But I dont think there is. What we dont want to do is we do not want to perforate. Because that would require tissue. So, I think the emphasis on diseases like Stevens-Johnson need to be in the acute care of these patients. And that really means the hospitals have to have good communication with the ophthalmologist so that there can be aggressive in that early acute phase. When there is actually something we can do for these patients and not in the end stage where theres very little we can offer these patients ...
Translational research for Spinal Cord Injury including cellular transplantation and neural tissue protection,especially as applies to mild hypothermia.
Combining the kinase inhibitor Imbruvica (ibrutinib) with an investigational personalized cellular therapy known as CTL119 can lead to complete remission in patients with high-risk chronic lymphocytic leukemia (CLL), according to new research from the Perelman School of Medicine at the University of Pennsylvania and Penns Abramson Cancer Center (ACC). The team will present the results from its pilot study […]. ...
Rikke Bech, Babak Jalilian, Ralf Agger, Lars Iversen, Mogens Erlandsen, Kristian Otkjaer, Claus Johansen, Søren R. Paludan, Carina A. Rosenberg, Knud Kragballe, Thomas Vorup-Jensen ...
Oct 23, 2008 - Opexa Therapeutics, Inc. (NASDAQ OPXA), a company dedicated to the development of patient-specific cellular therapies for the treatment of autoim
This form must be completed when a new malignancy is reported on a Cellular Therapy Essential Data Follow-Up Form (Form 4100). Reported new malignancies should...
TY - JOUR. T1 - Low-dose curcumin stimulates proliferation, migration and phagocytic activity of olfactory ensheathing cells. AU - Velasquez, Johana Tello. AU - Watts, Michelle E.. AU - Todorovic, Michael. AU - Nazareth, Lynnmaria. AU - Pastrana, Erika. AU - Diaz-Nido, Javier. AU - Lim, Filip. AU - Ekberg, Jenny A K. AU - Quinn, Ronald J.. AU - St John, James A.. PY - 2014/10/31. Y1 - 2014/10/31. N2 - One of the promising strategies for neural repair therapies is the transplantation of olfactory ensheathing cells (OECs) which are the glial cells of the olfactory system. We evaluated the effects of curcumin on the behaviour of mouse OECs to determine if it could be of use to further enhance the therapeutic potential of OECs. Curcumin, a natural polyphenol compound found in the spice turmeric, is known for its anti-cancer properties at doses over 10 μM, and often at 50 μM, and it exerts its effects on cancer cells in part by activation of MAP kinases. In contrast, we found that low-dose curcumin ...
Watzlawick R, Rind J, Sena ES, Brommer B, Zhang T, Kopp MA, Dirnagl U, Macleod MR, Howells DW, Schwab JM Olfactory ensheathing cell (OEC) transplantation is …
Olfactory ensheathing cells (OECs) accompany the axons of olfactory receptor neurons, which regenerate throughout life, from the olfactory mucosa into the olfactory bulb. OECs have shown widely varying efficacy in repairing the injured nervous system. Analysis of the transcriptome of OECs will help in understanding their biology and will provide tools for investigating the mechanisms of their efficacy and interactions with host tissues in lesion models. In this study, we compared the transcriptional profile of cultured OECs with that of Schwann cells (SCs) and astrocytes (ACs), two glial cell types to which OECs have similarities. Two biological replicates of RNA from cultured OECs, SCs, and ACs were hybridized to long oligo rat 5K arrays against a common reference pool of RNA (50% cultured fibroblast RNA and 50% neonatal rat brain RNA). Transcriptional profiles were analyzed by hierarchical clustering, Principal Components Analysis, and the Venn diagram. The three glial cell types had similarly
TY - JOUR. T1 - Liver regeneration and energetic changes in rats following hepatic radiation therapy and hepatocyte transplantation by 31P MRSI. AU - Landis, Charles S.. AU - Zhou, Hongchao. AU - Liu, Laibin. AU - Hetherington, Hoby P.. AU - Guha, Chandan. N1 - Publisher Copyright: © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.. PY - 2015/4/1. Y1 - 2015/4/1. N2 - Radiation-induced liver damage (RILD) is a poorly understood and potentially devastating complication of hepatic radiation therapy (RT) for liver cancers. Previous work has demonstrated that hepatocyte transplantation (HT) can ameliorate RILD in rats. We hypothesized that RT inhibits generation of cellular ATP and suppresses hepatic regeneration. Methods: To study the metabolic changes that occur in RILD with and without HT, 31P MRSI data were acquired in rats treated with partial hepatectomy (PH) alone, PH with hepatic irradiation (PHRT) or PHRT with HT (PHRT+HT). Results: Both [γ -ATP] and ATP/Pi 31P MRSI signal ...
TY - JOUR. T1 - Administration of control-released hepatocyte growth factor enhances the efficacy of skeletal myoblast transplantation in rat infarcted hearts by greatly increasing both quantity and quality of the graft. AU - Tambara, Keiichi. AU - Premaratne, Goditha U.. AU - Sakaguchi, Genichi. AU - Kanemitsu, Naoki. AU - Lin, Xue. AU - Nakajima, Hiroyuki. AU - Sakakibara, Yutaka. AU - Kimura, Yu. AU - Yamamoto, Masaya. AU - Tabata, Yasuhiko. AU - Ikeda, Tadashi. AU - Komeda, Masashi. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2005/8/30. Y1 - 2005/8/30. N2 - Background - We investigated whether simultaneous administration of control-released hepatocyte growth factor (HGF) enhances the efficacy of skeletal myoblast (SM) transplantation (Tx) through its antiapoptotic, angiogenic, and antifibrotic effects in myocardial infarction (MI). Methods and Results - Forty-eight Lewis rats with chronic MI were divided into 4 groups. In Group I (n = 14), neonatal SMs (5 × 106) ...
Bullous keratopathy is a condition where corneal endothelial cells, which do not normally proliferate in vivo, are extensively impaired by trauma, disease, surgery or the like and do not longer maintain the transparency of the cornea, leading to edema and turbidity. Kyoto Prefectural University of Medicine and Doshisha University jointly expanded corneal endothelial cells derived from donors and injected them into the anterior chamber of patients with keratopathy. 11 cases of a clinical study now confirmed effectiveness and safety of this treatment.. AMED news release, March 15, 2018. ...
Study Design. Two groups of 6 rats received dorsolateral funiculotomies followed by direct injection of bone marrow stromal Z-IETD-FMK ic50 cells (MSC) or mono-nuclear fraction of bone marrow (mnBM). Animals were killed at 4 or 21 days.. Objective. Cellular transplantation is a promising treatment strategy for spinal cord injury (SCI); however, most cells need to be cultured before transplantation introducing burdensome steps for clinical application. Cells immediately available for transplantation, like mnBM, would be preferable.. Summary of Background Data. Previous studies have shown that MSC transplants promote protection and repair after SCI. MSC are attractive for transplantation because of easy isolation and availability of autologous sources. MSC are derived from whole bone marrow, purified and Elafibranor ic50 expanded in culture for a period of at least 2 weeks. Alternatively, mnBM could be used for transplantation. mnBM derived from bone marrow from through simple centrifugation can ...
View full text. Author: Vácz G, Cselenyák A, Cserép Z, Benkő R, Kovács E, Pankotai E, Lindenmair A, Wolbank S, Schwarz CM, Horváthy DB, Kiss L, Hornyák I, Lacza Z.. Year: 2016. Journal: Interv Med Appl Sci.. Volume: 8. Issue: 4. Pages: H848-H857. doi: 10.1556/1646.8.2016.4.6.. PubMed PMID: 28180006. PubMed Central PMCID: PMC5283775.. Cited: 4. ...
Dedicated to Improving Your Quality of Life through the Use of Cellular Therapy.. We are a team of experts with more than 9 years of experience in the Cellular Therapy field. We provide the highest quality care during your quest to feel your best.. In recent years, there have been many exciting breakthroughs and therapeutic advances using cellular therapy. Our team of world class scientists has developed safe and effective procedures that may help improve your quality of life.. Cellular therapies may repair damaged tissues through various mechanisms of action. It has been proven that stem cells promote vascular repair and release growth factors that may help your own damaged cells and tissues heal.. Before undergoing cellular therapy, you should evaluate the provider. Ask them to describe the scientific support for the procedure and make sure that they are certified to perform it. Rehealths protocols and procedures are certified by COFEPRIS-Mexicos equivalent to US FDA. ...
Cardiomyoplasty is used when cardiac transplantation is not an option and the patient is asymptomatic at rest. The latissimus dorsum muscle is dissected free of its distal insertion and is wrapped around the heart. For the next 2 months, the muscle is stimulated with increasing frequency until it can contract in synchrony with each heartbeat. Six months after surgery, effects of an enhanced cardiac output should be evident.. ...
CAR-T Cells represent the first example of a cellular therapy that has moved from immunological concepts developed in research laboratories to worldwide and large-scale industry-manufacturing of potent therapeutic agents. The bumpy road* for these developments exemplify the many scientific challenges that await developers of this class of therapeutics. While scientific developments continue to occur at a high pace for CAR-T and CAR NK therapies, the race to solve the logistical, medical, financial and societal issues is engaged, with the goal to bring this class of therapeutics to all patients in need of them. CAR-T and CAR NK Cells will likely pave the way for other forms of immune cellular therapies, but also for regenerative medicines. ...
[113 Pages Report] Check for Discount on Global Systemic Mycoses Market Research Report 2017 report by QYResearch Group. In this report, the global Systemic Mycoses market is valued...
Background: The failure of regeneration after spinal cord injury (SCI) has been attributed to axonal demyelination and neuronal death. Cellular replacement and white matter regeneration are both necessary for SCI repair. In this study, we evaluated the co-transplantation of olfactory ensheathing cells (OEC) and embryonic stem (ES) cell-derived motor neurons ...
In the present study, we have shown that Robo proteins are expressed in cultured OECs and exhibit enriched distribution at the leading edge. A Slit-2 gradient indeed strongly repelled the migration of these cultured OECs. To our knowledge, this is the first guidance factor discovered to repel OEC migration. Because Slit-2 is highly expressed in the apical cells of OE, it is likely that it might help Robo-expressing OECs and olfactory axons migrate out of the OE through chemorepulsion during early development. Slits expressing in the OB might also regulate the stop and scattering of OECs that have arrived at the surface of the OB. OECs have been reported to pioneer the olfactory sensory nerves and provide a conductive substrate for the growth of olfactory sensory axons during development (Tennent and Chuah, 1996; Tisay and Key, 1999). An intriguing possibility is that the guidance of OECs by Slits might contribute to the guidance of axons because of the close interaction between neurons and glia. ...
The same three patients were exhibiting signs of sinusitis [13] also. trigeminal nerves FRP (olfactory ensheathing cells and trigeminal Schwann cells, respectively). Bacterias had been degraded by some cells but persisted in additional cells, which resulted in the forming of multinucleated huge cells (MNGCs), with olfactory ensheathing cells less inclined to type MNGCs than Schwann cells. Cap mutant bacteria Double, missing the protein BimA, didnt type MNGCs. These data claim that injuries towards the olfactory epithelium expose the principal olfactory anxious program to bacterial invasion, that may then bring about CNS disease with potential pathogenic outcomes for the glial cells. Writer summary Infections from the central anxious program (CNS), though unusual, are connected with serious mortality and morbidity. can enter the CNS via peripheral nerves increasing between the nose cavity and the mind (bypassing the blood-brain/blood-cerebrospinal Hydroxycotinine liquid barriers). In todays ...
AUTOLOGOUS CHONDROCYTE TRANSPLANTATION Melanie McNeal, PT, CSCS, CFT for patients of DAVID LINTNER, MD Articular cartilage (AC) provides a resilient surface for friction free movement of joints. It must bear ...
There is compelling experimental evidence to show that transplantation of skeletal myoblasts (SMBs) improves the function of failing hearts via paracrine effects. However, clinical application of this strategy has been curtailed due to arrhythmia occurrence and inconsistent outcomes observed in previous clinical trials of intramyocardial (IM) injection of SMBs. Severe inflammation and resultant global reduction of connexin43 have been reported to be causes of the arrhythmogenicity. Recent developments in bioengineering technology enabled production of cell sheets using temperature-responsive culture dishes, which allows retrieval of cells without enzymatic dissociation-related damages. We hypothesized that epicardial attachment of cell sheets would enhance retention, survival, and maintenance of functions of donor SMBs in the heart, with less myocardial injury, and therefore overcome the drawbacks of IM injection.. Methods & Results: After left coronary artery ligation in female Lewis rats, ...
Brigitte Bisaro, Giorgia Mandili, Alice Poli, Andrea Piolatto, Valentina Papa, Francesco Novelli, Giovanna Cenacchi, Marco Forni, Cristina Zanini ...
More precise dosing methods and cellular engineering techniques show promise in the effort to improve treatment of aggressive cancers with personalized cellular therapies, according to new studies from researchers in the ...
Olfactory ensheathing cells (OECs) are a type of specialized glial cell currently considered as having a double function in the nervous system: one regenerative, and another immune. OEC cultures resulted in continuous NF-B activation. The IFN-induced increase of iNOS manifestation was reversed in infected OECs. OECs are susceptible to infection, which can suppress their cytotoxic mechanisms in order to survive. We suggest that, in contrast to microglia, OECs might serve as safe focuses on for pneumococci, providing a more stable environment for evasion of the immune system. Olfactory ensheathing cells (OECs) are a type of specialized glial cell that accompany and ensheath the primary olfactory axons through the olfactory pathway, from your olfactory epithelium to Natamycin small molecule kinase inhibitor the olfactory tract. OECs are crucial for olfactory axonal assistance and outgrowth inside the developing and adult olfactory program1,2. This real estate of OECs makes them a superb candidate ...
View more ,Abstract Background The purpose of this study was to analyze olfactory ensheathing cell (OEC) proliferation and growth on Biosilicate and collagen bioscaffolds, and to determine whether the application of laser phototherapy would result in increased OEC proliferation on the scaffolds. The use of bioscaffolds is considered a promising strategy in a number of clinical applications where tissue healing is suboptimal. As in vitro OEC growth is a slow process, laser phototherapy could be useful to stimulate proliferation on bioscaffolds. Methods OEC cells were seeded on the Biosilicate and collagen scaffolds. Seeded scaffolds were irradiated with a single exposure of 830-nm laser. Nonirradiated seeded scaffolds acted as negative controls. Cell proliferation was assessed 7 days after irradiation. Results OECs were successfully grown on discs composed of a glass-ceramic and collagen composite. Laser irradiation produced a 32.7% decrease and a 13.2% increase in OEC proliferation on ...
TY - JOUR. T1 - Activation of the Wnt/β-catenin signaling reporter in developing mouse olfactory nerve layer marks a specialized subgroup of olfactory ensheathing cells. AU - Wang, Ya Zhou. AU - Molotkov, Andrei. AU - Song, Lanying. AU - Li, Yunhong. AU - Pleasure, David E. AU - Zhou, Chengji. PY - 2008/11. Y1 - 2008/11. N2 - Wnt reporter TOPgal mice carry a β-galactosidase (βgal) gene under the control of the Wnt/β-catenin signaling responsive elements. We found that the intensely immunolabeled βgal+ cells were co-immunolabeled with Nestin and formed a tangentially oriented single-cell layer in the connecting or docking zone where the olfactory sensory axons attached to the brain surface during mid-gestation. During early postnatal development, βgal+ cells were located in the inner olfactory nerve layer (ONLi) and co-labeled with olfactory ensheathing cell (OEC) markers S100β and NPY but not with lineage-specific markers for neurons, oligodendrocytes, astrocytes, and microglia, ...
Cell transplantation therapy is emerging as a promising mode of treatment following myocardial infarction. Of the various cell types that can potentially be used for transplantation, autologous skeletal myoblasts appear particularly attractive, because this would avoid issues of immunogenicity, tumorigenesis, ethics and donor availability. Additionally, skeletal myoblasts display much higher levels of ischemic tolerance and graft survival compared to other cell types. There is some evidence for improvement in heart function with skeletal myoblast transplantation. However, histological analysis revealed that transplanted myoblasts do not transdifferentiate into functional cardiomyocytes in situ. This is evident by the lack of expression of cardiac-specific antigens, and the absence of intercalated disc formation. Instead, there is differentiation into myotubes that are not electromechanically coupled to neighboring cardiomyocytes. This could in turn limit the clinical efficacy of treatment. This ...
After scientists injected paralyzed dogs at their injury sites with so-called olfactory ensheathing cells (OEC) taken from the linings of their noses, some were eventually able to walk. All the animals in the study suffered spinal injuries which prevented them from using or feeling anything in their hind legs.. Our findings are extremely exciting because they show for the first time that transplanting these types of cell into a severely damaged spinal cord can bring about significant improvement, study author Robert Franklin, a regeneration biologist at the Wellcome Trust-MRC Stem Cell Institute, said in a press release. Were confident that the technique might be able to restore at least a small amount of movement in human patients with spinal cord injuries but thats a long way from saying they might be able to regain all lost function.. YAY Science!. Now it seems the treatment has yet to be refined further but read the article and check out the quick video clip below.. ...
By: Dominik Zbogar This is a summary of a paper by researchers in Poland. Original article: Pawel Tabakow et al. (2014). Functional regeneration of supraspinal connections in a patient with transected spinal cord following transplantation of bulbar olfactory ensheathing cells Read More…. ...
Full time, Fixed term for 1 Year). The fellow will work full-time towards an MD(res) or PhD degree under the supervision of Dr. S. Saadoun and Prof. M.C. Papadopoulos within the Department of Neurosurgery. The project involves culturing human olfactory ensheathing cells, from olfactory bulbs, and implanting them into injured human spinal cord to promote neurological recovery.. National Training Number in Neurosurgery and successful attainment of at least ST4 level clinical training are essential requirements. Practical laboratory experience in cell culture and cell-based assays are desirable. The fellow will participate in the neurosurgery registrar on call rota and in daily clinical neurosurgery teaching.. For further information about this position, and to apply, visit ...
FP4,,2.5,University of Newcastle upon Tyne(UK),Università degli Studi di Torino(IT),Johann-Wolfgang-Goethe Universität Frankfurt(DE),MRC Clinical Sciences Centre(UK),Hebrew University of Jerusalem The Authority for Research and Development(IL),Rheinische Friedrich-Wilhelms-Universität Bonn(DE),Tel Aviv University(IL),Università degli Studi di Trieste(IT),Istituto Nazionale per la Ricerca sul Cancro(IT)
De Potter, Patrick. Clinical case--photo essay. Primary cyst of the iris pigment epithelium.. In: Bulletin de la Société belge dophtalmologie, , no. 307, p. 63-4 (2008 ...
Left ventricular function changes after cardiomyoplasty in patients with dilated cardiomyopathy.: Dynamic cardiomyoplasty has been reported in the treatment of
Immortalized hepatocytes are an attractive cell source for hepatocyte transplantation and gene transfer. We compared the phenotype and immunogenicity of freshly isolated (FIH) and immortalized (IMH) rat hepatocytes. Effect of culture and proinflammatory cytokines (TNF-agr, IFN-ggr) was studied on phenotype. FIH were isolated by collagenase digestion. Two SV40 immortalized hepatocyte cell lines were tested (RH1 and P9). Immunophenotyping was performed by FACS analysis using anti-rat-specific antibodies. Immunogenicity was evaluated by a mixed lymphocyte hepatocyte reaction (MLHR). FIH suspension was an almost homogeneous parenchymal cell population with few (1-2%) CD8+ cells. FIH showed a positive staining for ICAM-1 (20-35%) and for Class I (RT1A, 30-60%) but no staining for Class II (RT1B). After 48 h of culture, the already ICAM-1-positive cells were more strongly stained and additionally 3.6% of the cells (possibly endothelial cells) were Class II positive. IMH showed a consistent expression ...
Summary of Facts and Submissions. I. European patent application No. 00 948 918.8 with the title Muscle cells and their use in cardiac repair filed as a International application PCT/US 00/20129 was published under No. WO 01/07568. It was refused by the examining division in a decision dated 15 September 2006.. II. The decision of the examining division was taken on the basis of a main request and seven auxiliary requests which were all found to lack of novelty.. Claim 1 of said main request read as follows:. 1. A transplantable composition comprising isolated adult skeletal myoblast cells and isolated fibroblast cells, wherein the composition comprises from 20 to 70% skeletal myoblast cells. (see decision of the examining division, section X). The examining division observed, in particular, that document (4) on file (infra) described a composition of skeletal myoblast and fibroblast cells which were adult cells since the donor was identified as the subject of myocardial treatment. The ...
E barriers to cellular therapy. Several recent studies on solid extra-cranial neoplasms have shown that strategic timing of chemotherapy and immunotherapy,
What is a peptide? Learn about our peptide research, synthesis and mapping for treatments as well as the science behind cellular therapy.
Chengdu Biopurify offers Retrorsine [480-54-6] - Synonym name: Beta-Longilobine Catalogue No.:... Customizes high quality Phytochemicals, from grams to kilograms, GMP is available. Offers compound library and high quality Herb Extracts.
Cellular therapy is an emerging and evolving field. Through these Common Standards, FACT is expanding its services to facilities utilizing cellular therapy products to improve outcomes in patients suffering from a variety of diseases and conditions. Ideally, various discipline-specific or product specific standards would be added in the future with the input, collaboration, and acceptance of those experts actively involved in the field and their clinical and laboratory programs that volunteer to comply with them. These Common Standards are not intended to apply to hematopoietic cellular therapy programs or to cord blood banks. More detailed and specific standards already exist for both these disciplines, and FACT accreditation based on these specific standards is available.. Obtain Common Standards. ...
Long noncoding RNA lncHand2 promotes liver repopulation via c-Met signaling. Wang Y, Zhu P, Wang J, Zhu X, Luo J, Meng S, Wu J, Ye B, He L, Du Y, He L, Chen R, Tian Y, Fan Z. J Hepatol. 2018 Oct;69(4):861-872. doi: 10.1016/j.jhep.2018.03.029. Epub 2018 Apr 11. ...
Professor Gupta, a virologist, was the lead author in a study which made headlines this year reporting that a second HIV-infected person was
"A New Chapter for Cell Transplantation". Cell Transplantation. 26 (7): 1115. doi:10.1177/0963689717716682. ISSN 0963-6897. PMC ... Cell Transplantation is a monthly peer-reviewed medical journal covering regenerative medicine. It was established in 1992 and ...
In a summary of the 1977 Workshop on Pancreatic Islet Cell Transplantation in Diabetes, Lacy commented on the feasibility of " ... Lacy PE (April 1978). "Workshop on Pancreatic Islet Cell Transplantation in Diabetes sponsored by the National Institute of ... Islet transplantation is the transplantation of isolated islets from a donor pancreas into another person. It is an ... "islet cell transplantation as a therapeutic approach [for] the possible prevention of the complications of diabetes in man". ...
Peripheral blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", is a method of replacing blood- ... "Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation". 2005-09-09. Welte, K; Gabrilove, J; Bronchud, MH; ... Cutler, C; Antin, JH (2001). "Peripheral blood stem cells for allogeneic transplantation: a review". Stem Cells. 19 (2): 108-17 ... The transplantation may be autologous (an individual's own blood cells), allogeneic (blood cells donated by someone else with ...
Thomas' hematopoietic cell transplantation: stem cell transplantation. 5th ed. Vol. 2. New Jersey: Wiley-Blackwell; 2016. p. ... Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... Stem-cell transplantation was pioneered using bone marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research ... Cutler C, Antin JH (2001). "Peripheral blood stem cells for allogeneic transplantation: a review". Stem Cells. 19 (2): 108-117 ...
... is a procedure in which a patient receives blood-forming stem cells (cells from which all ... Syngeneic stem cell transplantation entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public ... blood cells develop) donated by his or her healthy identical twin. ... Organ transplantation, All stub articles, Surgery stubs). ...
... is autologous transplantation of stem cells-that is, transplantation in which stem cells (undifferentiated cells from which ... Autologous hematopoietic stem-cell transplantation Stem-cell therapy "What Are Stem Cells?". Retrieved 2017-02-12. Mahla RS ( ... Autologous stem-cell transplantation is distinguished from allogenic stem cell transplantation where the donor and the ... Autologous stem-cell transplantation (also called autogenous, autogeneic, or autogenic stem-cell transplantation and ...
... and nucleated cells. The adult stem cell fraction is present in the nucleated cells of the marrow. Most of these cells are ... Mesenchymal stem cells were originally discovered and studied as fibroblast-colony forming cells in guinea-pig bone marrow and ... There are five types of stem cells and MSC's are multi-potent meaning they are cells that have the ability to develop into more ... Mesenchymal stem cells (MSCs) are multipotent cells found in multiple human adult tissues including bone marrow, synovial ...
"National Organ, Tissue and Cell Transplantation Policy" (ODF). Malaysian Society of Transplantation. Transplantation Services ... The National Organ, Tissue and Cell Transplantation Policy is a policy that was formulated by the Surgical and Emergency ... Its main objective is to spread correct information and increase awareness on organ donation and transplantation in Malaysia. ... tissue and cells donation in Malaysia. The NTRC also collaborate with various NGOs, religious bodies, students' association, ...
Hematopoietic stem cell transplantation may be used to treat a number of conditions both congenital and acquired. Malignancies ... "Conditions stem cell transplant can cure". INDHEAL. (Stem cells). ... "Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation". N Engl J Med. 360 (7): 692-698. doi:10.1056/ ... Immunodeficiencies T-cell deficiencies Ataxia-telangiectasia DiGeorge syndrome Combined T- and B-cell deficiencies Severe ...
Stem cells and dermal papilla cells have been discovered in hair follicles. Research on these follicular cells may lead to ... Hair transplantation can also be used to restore eyelashes, eyebrows, beard hair, chest hair, pubic hair and to fill in scars ... Hair transplantation is a surgical technique that removes hair follicles from one part of the body, called the 'donor site', to ... Hair transplantation differs from skin grafting in that grafts contain almost all of the epidermis and dermis surrounding the ...
... stem cells or healthy cells extracted from the donor site). 1869: First skin autograft-transplantation by Carl Bunger, who ... using person's own cells via stem cells, or healthy cells extracted from the failing organs. Deceased donors (formerly ... See WHO Guiding Principles on human cell, tissue and organ transplantation, Annexed to World Health Organization, 2008. ... Thyroid transplantation became the model for a whole new therapeutic strategy: organ transplantation. After the example of the ...
2004). Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation. Nature medicine, 10(11), 1227-1233 ... ABO-incompatible (ABOi) transplantation is a method of allocation in organ transplantation that permits more efficient use of ... American Society of Transplantation. Retrieved from "ABO Incompatible Heart Transplantation in Young Infants , American Society ... 2007). Multicenter Experience of ABO-Incompatible Pediatric Cardiac Transplantation. American Journal of Transplantation, 0(0 ...
Transplantation. 85 (9): 1311-7. doi:10.1097/TP.0b013e31816c4ec5. PMC 3796953. PMID 18475189. Koss LG. On decoy cells. Acta ... Decoy cells are virally infected epithelial cells that can be found in the urine. Decoy cells owe their name to their strong ... In our experience, these features make decoy cells different from tubular cells and transitional cells found in all other ... or the other way around where cancer cells can be mistaken for decoy cells. Decoy cells themselves do not cause any disease, ...
Transplantation. 65 (10): 1396-7. doi:10.1097/00007890-199805270-00019. PMID 9625025. Engels EA, Frisch M, Goedert JJ, Biggar ... basal cell skin carcinoma, extrapulmonary small cell carcinoma, and EGFR mutation-driven non-small cell lung cancer have been ... "Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens". Journal of Virology. 84 ... Knockdown of these viral proteins causes cells from MCV-positive MCC tumors to die whereas there is no effect on cells from ...
... and Recipient-derived DNA in Cell-free Urine Samples of Renal Transplantation Recipients: Urinary DNA Chimerism". Clinical ... Urinary cell-free DNA (ucfDNA) refers to DNA fragments in urine released by urogenital and non-urogenital cells. Shed cells on ... Most ucfDNA is derived from urogenital tract cells. Approximately over 3×106 urogenital tract cells are exfoliated into urine ... Prenatal diagnosis Organ transplantation Detect rejection after renal transplantation Diagnosis of cancer can be performed by ...
... is a carbohydrate found in most mammalian cell membranes. It is not found in catarrhines, including humans, who have lost the ... leading to organ rejection after transplantation. Anti-alpha gal immunoglobulin G antibodies are some of the most common in ... Transplantation. 69 (12): 2504-15. doi:10.1097/00007890-200006270-00008. PMID 10910270. Macher, BA; Galili, U (February 2008 ... Cell Host & Microbe, 29 (3). Cowan PJ, Aminian A, Barlow H, Brown AA, Chen CG, ...
"Suppression of Allograft Rejection with Anti-αβ T Cell Receptor Antibody in Rat Corneal Transplantation?". Transplantation. 67 ... T-cells are able to distinguish between self and non-self largely through their T-cell receptor, or TCR. Immune tolerance is ... T-cell receptor stimulation is the primary signal required for the activation and differentiation of T-cells. Recognition of ... Wood, Kathryn J.; Sakaguchi, Shimon (2003). "Regulatory T cells in transplantation tolerance". Nature Reviews Immunology. 3 (3 ...
The freezers have attracted attention among organ banking and transplantation surgeons, as well as the food processing industry ... The Cells Alive System (CAS) is a line of commercial freezers manufactured by ABI Corporation, Ltd. of Chiba, Japan claimed to ... Transplantation. 94 (5): 449. doi:10.1097/TP.0b013e3182637097. ISSN 0041-1337. PMID 22895610. Cheng, Lina; Sun, Da-Wen; Zhu, ... Current Opinion in Organ Transplantation. 22 (3): 281-286. doi:10.1097/MOT.0000000000000403. ISSN 1087-2418. PMC 5520671. PMID ...
ATP and adenosine are released in high concentrations after catastrophic disruption of the cell, as occurs in necrotic cell ... Transplantation. 57 (2): 211-7. doi:10.1097/00007890-199401001-00010. PMID 8310510. Kalogeris T, Baines CP, Krenz M, Korthuis ... are molecules within cells that are a component of the innate immune response released from damaged or dying cells due to ... and it can lead to increased expression of cell adhesion molecules (ICAM-1, VCAM-1) on endothelial cells. DNA and RNA: The ...
Targeting BAFF-R interactions may provide new therapeutic possibilities in transplantation. Blisibimod, a fusion protein ... This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an ... This interaction triggers signals essential for the formation and maintenance of B cell, thus it is important for a B-cell ... Zhou T, Zhang J, Carter R, Kimberly R (2003). "BLyS and B cell autoimmunity". B Cell Biology in Autoimmunity. Current ...
T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation". Blood Cancer ... Cytotoxic T cells (TC cells, CTLs, T-killer cells, killer T cells) destroy virus-infected cells and tumor cells, and are also ... T helper cells (TH cells) assist other lymphocytes, including the maturation of B cells into plasma cells and memory B cells, ... Gamma delta T cells (γδ T cells) represent a small subset of T cells which possess a γδ TCR rather than the αβ TCR on the cell ...
An alternative to isolation and transplantation of large amounts of CD34+ cells is to add other types of veto cells and ... To name some of these cell types; CD34 cells, CD33 cells, CD8 T cells, Immature dendritic cells and NK cells among others. ... "Veto Cell Technologies - Cell Source". Retrieved 14 January 2019. "New Development in Cell Therapy: Veto Cell ... This means that T-cells with a T-cell receptor specific to antigens presented on the veto cell, bind to the veto cell, and are ...
... the spleen harbors primitive hematopoietic progenitor cells. Spleen transplantation has been performed on humans with mixed ... January 2011). "Graft-versus-host disease after intestinal and multivisceral transplantation". Transplantation. 91 (2): 219-224 ... Organ transplantation, Lymphatic organ surgery, Transplantation medicine, All stub articles, Medical treatment stubs). ... Spleen transplantation is the transfer of spleen or its fragments from one individual to another. It is under research for ...
Cell Transplantation. 21 (9): 1997-2008. doi:10.3727/096368911X637452. PMID 22469297. S2CID 21603693. Zhao, Dawen; Richer, ... Dead cells do not produce any bioluminescence due to absence of ATP The amount of the intensity of the signal is constant for ... Living cells that contain ATP produce a bioluminescent flash due to the luciferin-luciferase reaction in presence of ATP. ... In Vivo luminescence cell and animal imaging uses dyes and fluorescent proteins as chromophores. The characteristics of each ...
In addition, there is a risk of tumorigenesis after stem cell transplantation due to the ability of stem cells to proliferate ... Mesenchymal stem cells are able to differentiate, or mature from a less specialized cell to a more specialized cell type, to ... In mesenchymal stem cell therapy, most of the cells are extracted from the adult patient's bone marrow Mesenchymal stem cells ... Mesenchymal stem cells can also stimulate the maturation of antigen presenting cells. Antigen presenting cells trigger the ...
Cell Transplantation. 26 (9): 1560-1571. doi:10.1177/0963689717721234. PMC 5680957. PMID 29113464. Bailey, Suzanne (2021-11-30 ... In 2016 work published showing that it can reverse impaired calcium signalling in steatotic liver cells, which, in turn, might ... May 2009). "One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated ... Molecular Cell Research. 1863 (9): 2135-2146. doi:10.1016/j.bbamcr.2016.05.006. PMID 27178543. Tushuizen ME, Bunck MC, Pouwels ...
Clinical Transplantation. 14 (6): 586-91. doi:10.1034/j.1399-0012.2000.140612.x. PMID 11127313. Kwong YL, Wong KF (1998). " ... Association of pure red cell aplasia with T-cell large granular lymphocyte leukemia is well recognized, especially in China. ... genetic red cell aplasia) Aplastic anemia (aplasia affecting other bone marrow cells as well) Kaznelson P (1922). "Zur ... Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of aplastic anemia affecting the precursors to red blood ...
Wang S (March 2019). "Historical Review: Opiate Addiction and Opioid Receptors". Cell Transplantation. 28 (3): 233-238. doi: ...
Cell Transplantation. 4 (4): 385-392. doi:10.1016/0963-6897(95)00021-O. PMID 7582569. Lorenz, H. Peter; Lin, Richard Y.; ... CIK cells respond to lymphokines by lysing tumorous cells that are resistant to NK cells or LAK cell activity. CIK cells show a ... A mast cell is a white blood cell. Mast cells are protective cells that are involved in wound healing and blood-brain barrier ... "Distinguishing mast cell and granulocyte differentiation at the single cell level". Cell Stem Cell. 6 (4): 361-368. doi:10.1016 ...
... efficacy of 20 graft-versus-host disease prophylaxis therapies for patients after hematopoietic stem-cell transplantation: A ... In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to activate ... "Improved pharmacokinetic monitoring of tacrolimus exposure after pediatric renal transplantation". Pediatric Transplantation. ... The drug can also be sold as a topical medication in the treatment of T-cell-mediated diseases such as eczema and psoriasis. ...
Within molecular and cell biology, HLA-DQ3 (DQ3) is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9. ... For this reason DQ3 serotyping is a poor method of typing for transplantation or disease association prediction or study. ... implications for studies assessing the role of human Ia molecules in cell interactions and disease susceptibility". Proc. Natl ...
FUT2 fucosyltransferase transfers a fucose sugar to the end of the ABO(H) precursor in gastrointestinal cells and saliva glands ... such as those with common variable immunodeficiency or with a suppressed immune system after organ transplantation. These ... Entry into the host cell is achieved by attachment to host receptors, which mediates endocytosis. Positive-stranded RNA virus ...
Cell. 176 (5): 952-965. doi:10.1016/j.cell.2019.01.043. PMID 30794780. Wood AJ, Oakey RJ (November 2006). "Genomic imprinting ... Nucleus transplantation experiments in mouse zygotes in the early 1980s confirmed that normal development requires the ... of the parents and are maintained through mitotic cell divisions in the somatic cells of an organism. Appropriate imprinting of ... In germline cells the imprint is erased and then re-established according to the sex of the individual, i.e. in the developing ...
Its expression is restricted to cytotoxic immune cells such as cytotoxic T cells, NK cells, NKT cells and γδ T cells. Orthologs ... Krensky AM, Clayberger C (August 2005). "Granulysin: a novel host defense molecule". American Journal of Transplantation. 5 (8 ... such as NK cells, cytotoxic T cells, helper T cells, and in higher concentrations, immature dendritic cells. The 9 kDa form ... Granulysin is expressed in killer cells, such as cytotoxic T cells and Natural Killer (NK) cells, which hold the cytotoxic ...
The Institutional Ethics Committee The AMC Research Forum The Medical Education Cell Rasamayi Prakriti AURA (AMC Undergraduate ... who has been instrumental in developing the Kidney transplantation facility in the hospital. Department of Neurology Department ...
He continued his studies of small intestine transplantation under a Wellcome Trust travelling fellowship at University of ... unremarkable colonic histopathology results-noting no or minimal fluctuations in inflammatory cell populations-were changed ... Discordance with lymphocyte proliferative assays". Transplantation. 47 (3): 542-8. doi:10.1097/00007890-198903000-00028. PMID ... he was a member of a team that studied tissue rejection problems with small intestine transplantation, using animal models. ...
May 2018). "Allogeneic Stem Cell Transplantation for Advanced Myelodysplastic Syndrome: Comparison of Outcomes between CD34+ ... as a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of ... Cells expressing CD34 (CD34+ cell) are normally found in the umbilical cord and bone marrow as haematopoietic cells, or in ... December 2019). "Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia ...
... and stem cell transplantation. Pediatric cancers are treated by specialists at the UPMC Children's Hospital of Pittsburgh. The ...
... and CYP2C19 and survival of patients receiving cyclophosphamide prior to myeloablative hematopoietic stem cell transplantation ... "Toward personalized medicine in renal transplantation". Transplantation Proceedings. 42 (8): 2864-7. doi:10.1016/j.transproceed ...
When this is higher than the osmolarity outside of the cell, water flows into the cell through osmosis. This can cause the cell ... Transplantation. 23 (9): 2723-9. doi:10.1093/ndt/gfn325. PMID 18556748. Blaustein MP, Hamlyn JM (December 2010). "Signaling ... In fact, all cells expend a large fraction of the ATP they produce (typically 30% and up to 70% in nerve cells) to maintain ... Failure of the Na⁺-K⁺ pumps can result in swelling of the cell. A cell's osmolarity is the sum of the concentrations of the ...
"High expression of TIAF-1 in chronic kidney and liver allograft rejection and in activated T-helper cells". Transplantation. 75 ... Cell. 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573. v t e (Genes on human chromosome, All stub ... The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA ... Nature Cell Biology. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986. Schultz L, Khera S, Sleve D, Heath J, ...
Fisher, Andrew (6 June 2018). "Andrew Fisher on Magdi Yacoub: The icon at the heart of UK organ transplantation". British ... Jha, Alok (2 April 2007). "British team grows human heart valve from stem cells". The Guardian. London. Retrieved 23 November ... 2004: International Society for Heart and Lung Transplantation Lifetime Achievement Award, at the 24th annual meeting in San ... "The Telegraph - John McCafferty Longest Living Heart Transplantation Survival",, retrieved 9 February 2017 ...
... indicated for use in combination with filgrastim for mobilizing peripheral hematopoietic stem cells for later transplantation ... It is a 166 amino acid protein produced by E. coli bacteria into which a gene has been inserted for soluble human stem cell ... Ancestim is a recombinant methionyl human stem cell factor, branded by Amgen as StemGen. It was developed by Amgen and sold to ... 2004). "Ancestim (recombinant human stem cell factor, SCF) in association with filgrastim does not enhance chemotherapy and/or ...
Inside cells under normal conditions, lysosomes convert, or metabolize, lipids and proteins into smaller components to provide ... Furthermore, gene therapies and bone marrow transplantation may prove to be effective for certain lipid storage disorders. Diet ... These tests include clinical examination, biopsy, genetic testing, molecular analysis of cells or tissues, and enzyme assays. ... is any one of a group of inherited metabolic disorders in which harmful amounts of fats or lipids accumulate in some body cells ...
Polymorphonuclear cells also infiltrate the epithelium, and chronic inflammatory cells infiltrate the lamina propria. Atrophic ... organ transplantation and use of indwelling catheters). Oral candidiasis has been recognized throughout recorded history. The ... Apart from true hyphae, Candida can also form pseudohyphae - elongated filamentous cells, lined end to end. As a general rule, ... Smears and biopsies are usually stained with periodic acid-Schiff, which stains carbohydrates in fungal cell walls in magenta. ...
"Use of T-allo10 Cell Infusions Combined With Mismatched Related or Mismatched Unrelated Hematopoietic Stem Cell Transplantation ... Roncarolo has made major contributions in the field of cell and gene therapy. She performed fetal stem cell transplants given ... "Outstanding Achievement Award , ASGCT - American Society of Gene & Cell Therapy , ASGCT - American Society of Gene & Cell ... cells. Her team was the first to describe Tr1 cells while at DNAX Research Institute of Molecular and Cellular Biology, which ...
Organ transplantation Iván González Cancel is a cardiovascular and thoracic surgeon who is credited with the realization of the ... There he conducted research that would make him the foremost expert on cell makeup of the human eye lens. Alcalá developed ... He is a professor of surgery at the University of Puerto Rico and program director of transplantation of organs of the " ... Physiology is the study of life, specifically, how cells, tissues, and organisms function. She is a scientist who did her ...
Several cell types or tissues, e.g. osteoblasts, chondrocytes, cardiac tissue, gastrointestinal smooth muscle cells, and ... in serum LECT 2 levels during the early period of liver regeneration after adult living related donor liver transplantation". ... However, its expression in these cells is extremely low or undetectable even though these cells express very high levels of ... The protein was detected in and purified from cultures of Phytohaemagglutinin-activated human T-cell leukemia SKW-3 cells. ...
Hidradenitis has been diagnosed through an examination to confirm the presence of neutrophils (a type of immune cell present ... "Palmar Eccrine Hidradenitis Secondary to Trauma from Computer Gaming in an Adolescent After Bone Marrow Transplantation". ...
... such as the transplantation of pancreatic islet cells to treat patients with type 1 diabetes; a study to provide objective ...
Cell. Biol. 8 (2): 722-36. doi:10.1128/mcb.8.2.722. PMC 363198. PMID 2451124. Rosenberg M, Fuchs E, Le Beau MM, Eddy RL, Shows ... 2005). "Small urine leak after renal transplantation: detection by delayed 99mTc-DTPA renography--a case report". J Nucl Med ... Cell Genet. 57 (1): 33-8. doi:10.1159/000133109. PMID 1713141. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin ... 2005). "Identification of trichoplein, a novel keratin filament-binding protein". J. Cell Sci. 118 (Pt 5): 1081-90. doi:10.1242 ...
These simple transplantation methods follow from earlier observations by developmental biologists that germ stem cells are ... In usual circumstances, when foreign cells (such as cells or organs from other people, or infectious bacteria) are put into a ... "Repopulation of testicular Seminiferous tubules with foreign cells, corresponding resultant germ cells, and corresponding ... Cell Stem Cell. 23 (5): 665-676.e4. doi:10.1016/j.stem.2018.09.004. ISSN 1934-5909. PMID 30318303. (All articles with dead ...
Blood stem cells are young or immature cells that can transform into other forms of essential blood cell types (pluripotent), ... in order to support cord blood transplantations and related research in Singapore and around the world. SCBB is registered in ... such as red blood cells, white blood cells and platelets. The use of blood stem cells has emerged as a potentially curative ... matched stem cell units because of the relative scarcity of stem cell donors that matched Singapore's main ethnic profiles i.e ...
In 1975, association with "HL-A1,8" (Current name: HLA A1-B8) was confirmed by serological typing of cells from myasthenics. ... "Celiac disease autoantibodies in severe autoimmune liver disease and the effect of liver transplantation". Liver Int. 28 (4): ... These chromosome chimerize within the reproductive cells of each parent which are then passed to the developing person during ... make it useful for making cell lines that can be used to test serotyping antibodies. As a result, HLA-A1 and B8 produce some of ...
Mitchison discovered the transference of transplantation immunity by sensitised cells, thereby providing evidence relating ... Two are cell biologists Tim Mitchison and Hannah M. Mitchison. He was educated at Leighton Park School and secured a Classics ... His son is the cell biologist Tim Mitchison. He is married to Lorna Margaret Martin, daughter of Maj-Gen John Simson Stuart ... He devised a method for revealing mixtures of cells of different genotypes in vivo and used it to be equal first in ...
It works by affecting fungal metabolism and fungal cell membranes. Voriconazole was patented in 1990 and approved for medical ... Omrani AS, Almaghrabi RS (December 2017). "Complications of hematopoietic stem transplantation: Fungal infections". Hematology/ ... squamous cell skin cancer, and Stevens-Johnson syndrome; in long-term use there is a warning of the risk of bone fluorosis and ... Oncology and Stem Cell Therapy. 10 (4): 239-244. doi:10.1016/j.hemonc.2017.05.013. PMID 28636889. Herbrecht R, Denning DW, ...
Allogeneic stem cell transplantation can induce durable remissions for heavily pre-treated patients. As of October 2010, there ... lymphoplasmacytoid cells and plasma cells. Both cell types are white blood cells. It is characterized by having high levels of ... Yang L, Wen B, Li H, Yang M, Jin Y, Yang S, Tao J (1999). "Autologous peripheral blood stem cell transplantation for ... It is commonly classified as a form of plasma cell dyscrasia, similar to other plasma cell dyscrasias that, for example, lead ...
Research applications include transplantation research, induced arthritis and inflammation, experimental allergic encephalitis ... and C-cell adenomas/adenocarcinomas of the thyroid gland and tumors of the haemopoietic system in males. Second, Lewis rats are ... and gain weight from an increase in both the size and number of fat cells. Obesity in Zucker rats is primarily linked to their ... which lend themselves better to the embryonic stem cell techniques typically used for genetic manipulation. Many investigators ...
Relapse rates dropped to zero after an intensive regimen of autologous hematopoietic stem cell transplant, but improvement is ... Cite this: Stem Cell Transplantation a Potential Game Changer for MS? - Medscape - Mar 03, 2022. ... WEST PALM BEACH, Florida - Stem cell transplantation is tied to complete elimination of relapse in patients with aggressive ... followed by a conditioning regimen with high-dose chemotherapy to deplete immune cells and then infusion of stem cells back ...
The image below illustrates an algorithm for typically preferred hematopoietic stem cell transplantation cel... ... infusion of autologous or allogeneic stem cells to reestablish hematopoietic function in patients whose bone marrow or immune ... Hematopoietic stem cell transplantation (HSCT) involves the intravenous (IV) ... encoded search term (Hematopoietic Stem Cell Transplantation (HSCT)) and Hematopoietic Stem Cell Transplantation (HSCT) What to ...
WHO guiding principles on human cell, tissue and organ transplantation  World Health Organization (‎World Health Organization ... Aide-mémoire for national health authorities: access to safe and effective cells and tissues for transplantation  ... Aide-mémoire on key safety requirements for essential minimally processed human cells and tissues for transplantation  ... First global consultation on regulatory requirements for human cells and tissues for transplantation, Ottawa, 29 November to 1 ...
Allogeneic hematopoietic stem cell transplantation provides the most powerful antileukemic effect in the treatment of acute ... Cite this: Treatment of Acute Myeloid Leukemia With Hematopoietic Stem Cell Transplantation - Medscape - May 01, 2009. ... transplantation provides a means to rescue patients from agents that may eliminate normal hematopoietic stem cells as well as ... The natural killer cell alloreactive mechanism involving killer-cell immunoglobin-like receptors can reduce relapse rates in ...
... of combining pembrolizumab immunotherapy with standard chemotherapy drugs and autologous stem cell transplantation (ASCT) in ... A Phase II Study of Pembrolizumab Immunotherapy plus Chemotherapy followed by Autologous Stem Cell Transplantation for ... During ASCT, a patients own blood-forming stem cells are collected, and he or she is then treated with high doses of ... Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based ...
The two main types of stem cell transplantation are *Allogeneic stem cell transplantation, using stem cells from a matched or ... Allogeneic Stem Cell Transplantation. This is the most common type of stem cell transplantation used to treat AML. Allogeneic ... These new stem cells restore healthy stem cells in the bone marrow that can form new red blood cells, white blood cells and ... Autologous stem cell transplantation, using stem cells from the patient collected before chemotherapy ...
stem cell transplantation Clinical Research Trial Listings on CenterWatch ... T Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation Conditioned With a Reduced Intensity Regimen in Patients ... TLI, TBI, ATG & Hematopoietic Stem Cell Transplantation and Recipient T Regs Therapy in Living Donor Kidney Transplantation ... cell. transplantation. (allo-. HSCT. ) is a potentially curative therapy for many malignant or nonmalignant hematological ...
Drug-resistant immune cells protect patients from graft-versus-host disease after bone marrow transplant. ... T cells and Transplantation. Drug-resistant immune cells protect patients from graft-versus-host disease after bone marrow ... "It kills proliferating tumor cells," he explained.. This targeting of cycling cells was precisely the rationale for using the ... it spares regulatory T cells (Tregs)-immune-suppressing cells that promote tolerance of foreign tissue. ...
... can cause significant pulmonary morbidity and mortality in hematopoietic stem cell (HSCT) and less often in solid-organ ... Respiratory Syncytial Virus in Hematopoietic Stem Cell Transplantation and Solid-Organ Transplantation Curr Infect Dis Rep. ... can cause significant pulmonary morbidity and mortality in hematopoietic stem cell (HSCT) and less often in solid-organ ...
Patients who underwent cell therapy within 2 years after the stroke showed better changes. Ischemic type of stroke had better ... In this study, the effect of intrathecal administration of autologous bone marrow mononuclear cells (BMMNCs) is analyzed on the ... This study demonstrates the potential of autologous BMMNCs intrathecal transplantation in improving the prognosis of functional ... 24 patients diagnosed with chronic stroke were administered cell therapy, followed by multidisciplinary neurorehabilitation. ...
Marginal note:Cells, except islet cells. *. 30 (1) An establishment that distributes cells, except islet cells, must ensure ... Marginal note:Pancreas and islet cells. (2) An establishment that distributes a pancreas for islet cell transplantation, or ... Statement that the cell has been declared safe for transplantation. X. 13. Statement "For Exceptional Distribution", if ... Statement that the cells have been declared safe for transplantation. X. 15. Statement "For Exceptional Distribution", if ...
Hematopoietic Cell Transplantation: From a Curative Concept to Cure ... (label-accessed November 30, 2022). ... and establish essential supportive care methods to successfully perform clinical hematopoietic cell transplantation (HCT) ... severe red blood cell disorders such as sickle cell disease or thalassemia, and certain solid tumors. ...
Epidermal stem cells from an adult patient affected by LAM5-β3-deficient JEB were transduced with a retroviral vector ... Cultured keratinocyte stem cells, known as holoclones3,4,5,6, generate sheets of epithelium used to restore severe skin, ... The continuous renewal of human epidermis is sustained by stem cells contained in the epidermal basal layer and in hair ... site analysis indicated that the regenerated epidermis is maintained by a defined repertoire of transduced stem cells. These ...
CD34+ cells are multipotent hematopoietic stem cells also known as endothelial progenitor cells and are useful in regenerative ... CD34+ cells are multipotent hematopoietic stem cells also known as endothelial progenitor cells and are useful in regenerative ... First, CD34+ cells differentiate into smooth muscle cells and endothelial cells, which are the main structural components of ... therapeutic vasculogenesis by transplantation of human CD34+ cells and low dose CD34+KDR+ cells. FASEB J. 2004;18:1392-1394. [ ...
We discuss here recent advances obtained by combining regulatory T cell infusion with bone-marrow transplantation. In ... It has been proposed that bone marrow or hematopoietic stem-cell transplantation, and resulting (mixed) hematopoietic chimerism ... It is widely believed that bone marrow or hematopoietic stem cell transplantation, and resulting (mixed) hematopoietic ... A central role for active tolerance in transplantation-tolerance is also supported by recent data showing that genuine ...
Few studies are reported on the therapeutic effect of adipose-derived stem cells (ADSCs) transplantation in mice with AD and on ... Stem Cell Transplantation can Stimulate Generation of Neurons Following Alzheimers Disease Personalised Printable Document ( ... Treatment Genetics and Stem Cells Bone Marrow Transplantation Tissue Engineering and Regenerative Medicine Transplantation ... Alzheimers Disease Stem Cells - Cord Blood Parkinsons Disease Stem Cells - Fundamentals Parkinsons Disease Surgical ...
Faecal microbiota transplantation. GLP-1 receptor. exendin. beta cell mass. beta cell function. imaging. microbiome. ... BetaFIT Study: Beta Cell Imaging After Faecal mIcrobiota Transplantation (BetaFIT). The safety and scientific validity of this ... The Effects of Faecal Microbiota Transplantation on Beta Cell Preservation in Patients With Newly Diagnosed Type 1 Diabetes. ... However, it is unknown whether this is due to an increase in beta cell mass, or increased function of the remaining beta cells. ...
Bone marrow contains immature cells called stem cells. Stem cells can mature into blood cells (white blood cells, red blood ... it is referred to as peripheral blood stem cell transplantation (PBSCT).. For a stem cell transplant, stem cells from the ... Stem cell transplantation for Hodgkins disease usually involves harvesting the patients stem cells, from the bone marrow or ... The chemotherapy kills healthy cells as well. The transplanted stem cells replace the missing disease-free cells. ...
Beta cells make up 50%-70% of the cells in human pancreatic islets - groups of cells in the pancreas that produce blood glucose ... "We are so fortunate to have the Gordons support and shared vision to help us realize the potential of cell transplantation ... Accelerating Transformational Research into Cell Transplantation for Patients with Type 1 Diabetes By Kate Rix and Susan ... This creates an opportunity to engineer the stem cell-derived beta cells in ways that support their survival and help them ...
Analyses of Letermovir Following Oral and Intravenous Administration in Allogeneic Hematopoietic Cell Transplantation ...
Haplo T-Cell Depleted Transplantation in High-Risk Sickle Cell Disease (HaploSCD). The safety and scientific validity of this ... Significant improvement of child physical and emotional functioning after familial haploidentical stem cell transplant. Bone ...
Scientists Cure Sickle Cell Anemia in Mice (UAB, Whitehead 2008) * Sampling of Recent Stem Cell Research Reports Since ... by APFLI , Dec 22, 2015 , Adult & Umbilical Cord Stem Cell Research (Ethical), Artificial Conception, Stem Cell Research & ... U.S. House: Passed Ban on Production of 3-Parent Human Embryos & Reauthorized Programs Using Ethical Adult Stem Cells. ... U.S. House: Passed Ban on Production of 3-Parent Human Embryos & Reauthorized Programs Using Ethical Adult Stem Cells ...
Stem cell transplantation into mouse cochlea may impact future hearing loss therapies ... Cell Transplant. 21(4):763-771; 2012.. The Coeditor-in-chiefs for CELL TRANSPLANTATION are at the Diabetes Research Institute ... However, there was a difference in the number of cells present based on cell lines. They noted that the number of cells able to ... Stem cell transplantation into mouse cochlea may impact future hearing loss therapies. ...
Diffuse large B-cell lymphoma (DLBCL), NOS. * *Germinal center B-cell type* *Activated B-cell type* T-cell/histiocyte-rich ... Splenic B-cell lymphoma/leukemia, unclassifiable. * *Splenic diffuse red pulp small B-cell lymphoma *Hairy cell leukemia- ... Hematopoietic cell transplantation (HCT) involves the intravenous (IV) infusion of allogeneic (donor) or autologous stem cells ... T-cell Lymphoma. HCT may be considered medically necessary for individuals with mature T-cell or natural killer cell ( ...
Transplantation of autologous cells and biomaterials to promote wound healing. *Responsible researcher ... The project investigates novel methods for skin transplantation, with autologous skin cells in combination with biomaterial ...
S39-41 Haematopoietic stem cell transplantation for thalassaemia in Chinese patients CK Li, Vincent Lee, Matthew MK Shing, TF ... Advances in transfusion and iron chelation improve survival but haematopoietic stem cell transplantation (HSCT) is still the ... The result of unrelated-donor bone marrow transplantation is in general inferior but extended HLA matching may improve outcome ... Sibling cord blood and bone marrow transplantation has similar outcome. Recently alternative donor transplant has been ...
High-Dose Chemotherapy and Autologous Stem Cell Transplantation Improves Responses in Advanced Follicular Lymphoma ... Autologous Stem Cell Transplantation Improves Responses. High-Dose Chemotherapy and Autologous Stem Cell Transplantation ... The main cells in the lymph system are called lymphocytes, of which there are two types: B and T-cells. Each of these cells has ... All blood cells are derived from a common cell called the stem cell, which is produced in the bone marrow. The high doses of ...
Comment Template for the Draft Second Edition of the Safety of Human Cells, Tissues and Organs for Transplantation Guidance ... Comment Template for the Draft Second Edition of the Safety of Human Cells, Tissues and Organs for Transplantation Guidance ... Notice - Draft 2nd Edition Guidance Document for Cell, Tissue and Organ Establishments: Safety of Human Cells, Tissues and ... Consultation on draft Guidance for Sponsors: Preparation of Clinical Trial Applications for use of Cell Therapy Products in ...
Cell Stem Cell (2016) Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and ... and cell fate of stem cell-derived MGE cell transplants in the uninjured rodent spinal cord. We have now obtained preliminary ... and cell fate of stem cell-derived MGE cell transplants in the uninjured rodent spinal cord. We have now obtained preliminary ... Californias Stem Cell Agency California Institute for Regenerative Medicine. * For Researchers * Funding Opportunities * ...
2018 The European Society for Blood and Marrow Transplantation. All rights reserved ...
  • Worldwide, approximately 90,000 first HSCTs-53% autologous and 47% allogeneic-are performed every year, according to the World Wide Network of Blood and Marrow Transplantation. (
  • We discuss here recent advances obtained by combining regulatory T cell infusion with bone-marrow transplantation. (
  • If your cancer is not responding to chemotherapy or radiation, you may receive bone marrow transplantation or peripheral stem cell transplantation. (
  • Bone marrow transplantation is most effective when started soon after relapse. (
  • Sibling cord blood and bone marrow transplantation has similar outcome. (
  • The result of unrelated-donor bone marrow transplantation is in general inferior but extended HLA matching may improve outcome. (
  • Biology of Blood and Marrow Transplantation , 25 (7), 1424-1431. (
  • Although variables relating to disease biology and patient characteristics are strong determinants of outcome after bone marrow transplantation (BMT), the identification of these nonmodifiable factors is often of limited practical use. (
  • Dr. Jay Sarthy is a hematologist-oncologist who specializes in pediatric bone marrow transplantation for children with blood cancers and rare genetic conditions, such as telomere syndromes. (
  • Our blood and marrow transplantation specialist deliberated with Demier's parents and decided to proceed with a stem cell transplant when he was 3. (
  • Be The Match® is a global leader in bone marrow transplantation. (
  • He has received the 2013 Van Bekkum Award, the most prestigious European Blood and Marrow Transplantation (EBMT) award for the best abstract submitted to the physician''s programme. (
  • He has often been invited to present as Speaker to plenary sessions at international scientific meetings in the fields of MS, neuroimmunology and bone marrow transplantation. (
  • Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION . (
  • Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (
  • This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (
  • Respiratory syncytial virus (RSV), one of the most common causes of respiratory infections in immunocompetent individuals, can cause significant pulmonary morbidity and mortality in hematopoietic stem cell (HSCT) and less often in solid-organ transplant recipients. (
  • Advances in transfusion and iron chelation improve survival but haematopoietic stem cell transplantation (HSCT) is still the only curative treatment. (
  • Reliability and Validity of a Patient Self-Administered Daily Questionnaire to Assess Impact of Oral Mucositis (OM) on Pain and Daily Functioning in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation (HSCT)," Bone Marrow Transplant, Vol. 37, No. 4, 2006, pp. 393-401. (
  • The oral, fixed-combination NEPA containing netupitant and palonosetron target crucial pathways involved in both acute and delayed chemotherapy-induced nausea and vomiting (CINV) in patients with highly emetogenic chemotherapy.Hematopoietic stem cell transplantation (HSCT) is associated with infectious complications, especially bloodstream infections (BSI). (
  • Busulfan (BU) is a bi-functional DNA - alkylating agent used in patients undergoing hematopoietic stem cell transplantation (HSCT). (
  • His research programme is aimed at understanding and developing effective therapies for inflammatory neurological diseases, particularly multiple sclerosis (MS). His scientific contributions include studies of T cell repertoires in health and autoimmune disorders, and the elucidation of the mechanisms of action of immuno-modulatory treatments and haematopoietic stem cell transplantation (HSCT) in MS. (
  • [ 39 , 40 ] Isolated reports of hematopoietic allogeneic stem cell transplantation (HSCT) for pyruvate kinase deficiency have been published. (
  • In a retrospective study, investigators found patients with aggressive MS treated with autologous hematopoietic stem cell transplant (aHSCT) experienced complete elimination of relapse, with no need for new therapy with disease modifying treatments (DMT) during follow-up assessments up to 20 years. (
  • Ideally, an allogeneic stem cell transplant will generate a new immune system for the patient. (
  • This type of transplantation may be a treatment option for older patients who cannot tolerate the high doses of chemotherapy used in preparation for a standard allogeneic stem cell transplant. (
  • The conditioning therapy used for a reduced-intensity transplant is of lower intensity than that for a standard stem cell transplant. (
  • Drug-resistant immune cells protect patients from graft-versus-host disease after bone marrow transplant. (
  • This targeting of cycling cells was precisely the rationale for using the drug after bone marrow transplant. (
  • Now, Luznik and colleagues show that in patients who received bone marrow transplants and post-transplant cyclophosphamide, T reg proliferation did indeed increase, yet these cells remained resistant to cyclophosphamide. (
  • Before transplant, the patient is treated with high-dose chemotherapy, with or without radiation therapy, to eradicate the cancerous cells (prior to both autologous and allogeneic HCT), and to suppress the patient's immune system to prevent it from attacking the donor hematopoietic cells (prior to allogeneic HCT). (
  • More recently, it has been established that less intensive pre-transplant treatment also allows successful transplantation, but with less severe side effects. (
  • If PBSCs are used in the transplant, it is referred to as peripheral blood stem cell transplantation (PBSCT). (
  • For a stem cell transplant, stem cells from the peripheral blood or bone marrow are collected (harvested) and placed in frozen storage prior to treatment of the cancer with high-dose chemotherapy. (
  • If your own stem cells are used the transplant is called autologous. (
  • If a donor's cells are used, it is called and allogeneic transplant. (
  • Cell Transplant. (
  • Researchers have developed a way in which to replenish the low levels of blood cells following high-dose therapy, called an autologous stem cell transplant. (
  • Previous studies have demonstrated that treatment with high-dose chemotherapy and a stem cell transplant could cure some patients with follicular lymphoma who would otherwise be considered incurable with conventional chemotherapy. (
  • Treatment consisted of intensified induction chemotherapy followed by high-dose chemotherapy and an autologous stem cell transplant. (
  • Generating clinical-grade, pluripotent stem cells suitable for use in patients will take time: The first transplant conducted by BAIRT is expected to be at least three to four years off. (
  • However, the long-term survival of children assigned to the high-risk group is still poor, even under a comprehensive treatment regimen including intensive induction chemotherapy, surgery, radiotherapy, myeloablative chemotherapy with autologous stem cell transplant, and immunotherapy [ 3 - 5 ]. (
  • CITATION Cell Transplant. (
  • Human iPS cells are looked to as a potential source of the transplant cells. (
  • It is hoped that iPS cells will make it possible to use cells derived from the transplant patients themselves to perform autologous transplantation. (
  • Design, setting, participants, & measurements We performed a single-center, retrospective study of 616 allogeneic hematopoietic cell transplant recipients from 2014 to 2017. (
  • Conclusions AKI post-hematopoietic cell transplant remains a major concern. (
  • Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (
  • 1 On the other hand, treatment- and transplant-related factors, which are modifiable, can potentially be manipulated in clinical practice to improve the results of transplantation. (
  • The effect of cell dose on disease-free survival and transplant-related mortality in 85 AML patients allografted in first remission (cell numbers not available for two patients). (
  • We have also found in a number of different studies that the nucleated cell dose significantly affects transplant-related mortality, 1 , 3-5 survival, 1 , 3 and the speed as well as completeness of hematologic reconstitution after autologous 1 , 6 and allogeneic 3-5 transplantation for hematologic malignancies. (
  • 1 Because 2 × 10 8 /kg cells is our usual target for collection during an autologous marrow harvest, those receiving ≤2 × 10 8 /kg nucleated cells may have represented a group of patients with compromised marrow reserve due to either high-risk disease or previous chemotherapy who subsequently had problems during the transplant. (
  • The outcome of reduced intensity allogeneic stem cell transplantation and autologous stem cell transplantation when performed as a first transplant strategy in relapsed follicular lymphoma: an analysis from the Lymphoma Working Party of the EBMT. (
  • Treatment with androgens and hematopoietic (blood cell) growth factors can help bone marrow failure temporarily, but the long-term treatment is bone marrow transplant if a donor is available. (
  • Regarding the treatment of high-risk patients, autologous stem cell transplantation remains the standard of care in transplant-eligible candidates. (
  • The Young Professionals in Transplantation (YPT) is the Network for Junior Transplant professionals of ESOT, representing all young transplant clinicians and scientists who are beginning a career in transplantation and organ donation. (
  • Objective: To review and summarize nurses ' roles in the care of the older adult undergoing an allogeneic hematopoietic cell transplant (HCT) for the treatment of leukemia. (
  • Using this technology, they demonstrated for the first time that it is possible to transplant biliary cells grown in the lab into damaged human livers to repair them. (
  • When a patient needs a stem cell transplant, the physician's goal is to find donor stem cells that match the patient's Human Leukocyte Antigens, also known as HLA type. (
  • However, when matching cord blood cells are given together with haploidentical donor cells in a haplo-cord transplant, the two stem cell sources support each other and produce a better outcome than either alone. (
  • Thanks to the procedure, during which stem cells were harvested from a healthy donor, a bone marrow transplant was performed in Belgium, saving the life of a patient who suffered from a potentially terminal blood-related disease. (
  • With the successful completion of our first-ever stem cell harvesting procedure, which made possible a life-saving bone marrow transplant in Belgium, the decade-long work of our donors and volunteers has once again been rewarded. (
  • Commenting on the significance of the stem cell harvesting procedure on June 16, Dr. Avagyan said that from now on stem cell donors in Armenia and neighboring countries will no longer need to travel to Europe or elsewhere for harvesting procedures, as these will be performed in Yerevan, helping considerably reduce the cost of a bone marrow transplant. (
  • The Cord Blood Association, together with the National Marrow Donor Program (NMDP), worked tirelessly with members of Congress this year and testified in support of the legislation that totals $115 million for five years for the National Cord Blood Inventory (NCBI) and $150 million in that same period for blood and marrow transplant programs through the C.W. Bill Young Transplantation Program. (
  • When his leukemia relapsed, Brown was subjected to a second stem cell transplant. (
  • La información en esta página debería ser considerada como ejemplos de información de antecedentes para la temporada de influenza 2021-2022 para la práctica médica respecto del uso de medicamentos antivirales contra la influenza. (
  • The impact score (IS) 2021 of American Journal of Transplantation is 7.03 , which is computed in 2022 as per its definition. (
  • A serious risk of allogeneic and reduced-intensity allogenic stem cell transplantation is graft versus host disease (GVHD) , which develops if the donor's immune cells attack your normal tissue. (
  • A paper published today (November 13) in Science Translational Medicine reveals that while the compound destroys some immune cells that might cause graft-versus host disease, it spares regulatory T cells (T regs )-immune-suppressing cells that promote tolerance of foreign tissue. (
  • b) notify the establishments to whom it has distributed a cell, tissue or organ or made a donor referral, during the period specified in the notice, of the cancellation, the reasons for the cancellation and the effective date. (
  • Naturally, these cells are mobilized from the bone marrow into peripheral circulation in response to ischemic tissue injury. (
  • Currently, islet-cell replacement relies on obtaining pancreatic tissue from deceased human donors. (
  • This causes overcrowding of blood and lymph tissue, suppressing the formation and function of blood and immune cells that are normally present. (
  • hMAPC or hAC133(+) cell transplantation induced a significant improvement in tissue perfusion (measured by microPET) 15 days posttransplantation compared to controls. (
  • Our body fat is rich in mesenchymal stem cells [although it occurs in various concentrations in almost every tissue in the human body]. (
  • These cells normally lie dormant in the collagen matrix of the fat but can be released and activated to repair damaged tissue. (
  • Our treatments use mesenchymal stem cells found predominantly in fatty tissue. (
  • When injected into tissue, the stem cells tend to act in two main ways: first, by dividing and regenerating the aged tissue and secondly by secreting factors that help the surrounding cells to regenerate the tissue. (
  • Originally, mesenchymal stem cells were thought to be the drivers of tissue regeneration. (
  • First is the realization that this class of cells can be isolated from almost every tissue in the human body. (
  • By secreting factors that mute the immune system, the MSC-pericytes inhibit T-cell surveillance of the damaged tissue and bioactive agents are released by MSCs that establish a regenerative microenvironment. (
  • Infectious disease transmission through organ and tissue transplantation has been associated with severe complications in recipients. (
  • Determination of donor-derived infectious risk associated with organ and tissue transplantation is challenging and limited by availability and performance characteristics of current donor epidemiologic screening (e.g., questionnaire) and laboratory testing tools. (
  • The exact risk for infection associated with organ or tissue transplantation is unknown but is related to multiple factors, including epidemiology of specific infectious exposures, tissue tropism of the organism, and transmissibility of potential pathogens through transplantation. (
  • In an attempt to prevent donor-derived infections in transplantation, organ and tissue donors are evaluated to identify those that might be more likely to harbor transmissible pathogens. (
  • In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (
  • The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (
  • Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (
  • EDTCO aims to support health care professionals to provide clinically effective programmes on organ and tissue donation, procurement and transplantation. (
  • Also, based on findings on cell functions at the tissue level obtained by the analysis of the organ on a chip, cell delivery therapy was investigated. (
  • In order to recapitulate the ocular fundus functions, neural supporting cells such as retinal pigment epithelial (RPE) cells were cultured within a three-dimensional microfluidic device, and cell responses at the tissue level to changes in the microenvironment were analyzed. (
  • Also, the obtained results were applied to control the tissue functions of RPE cells cultured on the polymeric nanosheets, which was extended to a method to deliver an RPE sheet into the subretinal space. (
  • Journal Article] Three-dimensional co-culture of C2C12/PC12 cells improves skeletal muscle tissue formation and function. (
  • The only one of its kind in the Caucasus region, the Stem Cell Harvesting Center features a state-of-the-art tissue-typing laboratory, and can store and harvest stem cells provided by healthy bone marrow donors. (
  • Follow-up studies in 2011, including biopsies from his brain, intestine, and other organs, showed no signs of HIVÂ RNA or DNA, and also provided evidence for the replacement of long-lived host tissue cells with donor-derived cells. (
  • This report reviews the effects of dose of thymus tissue, ABO compatibility, HLA matching, culture conditions, age of donor and immunosuppression of recipient on immune outcomes at 1 year after transplantation. (
  • Use of thymus tissue from donors over 1 month of age, versus under 1 month, resulted in higher total T-cell numbers (p = 0.03). (
  • The majority of HCT recipients are patients with leukemia, lymphoma, myeloma, myelodysplasia, bone marrow failure conditions, severe red blood cell disorders such as sickle cell disease or thalassemia, and certain solid tumors. (
  • Donated blood is often used to treat pregnancy-related complications, anaemia, sickle cell disease and malaria. (
  • He was born with sickle cell disease, an inherited red blood cell disorder. (
  • Those studies can help identify various causes of splenomegaly, such as sickle cell disease, spherocytosis, and other hereditary hemolytic anemias. (
  • Reduction in vaso-occlusive events following stem cell transplantation in patients with sickle cell disease. (
  • An Overview of Solid Organ Transplantation in Patients With Sickle Cell Disease. (
  • Sickle cell disease is a group of red blood cell disorders passed by genes from parents to their children. (
  • Most children with sickle cell disease are pain-free between pain crises, but adolescents and adults may suffer from ongoing pain. (
  • Approximately 100,000 Americans have sickle cell disease. (
  • About one in every 365 black children is born with sickle cell disease. (
  • Learn how you can participate in NHLBI clinical trials related to sickle cell disease on NHLBI's website. (
  • Sickle cell disease is a lifelong illness. (
  • It is a growing option for people with sickle cell disease. (
  • The National Heart, Lung, and Blood Institute is leading a nationwide study to test the effects of an experimental gene therapy to treat sickle cell disease that involves removing a patient's bone marrow and then adding copies of a correctly spelled gene for normal hemoglobin to generate normal red blood cells. (
  • NHLBI researchers are studying the genetic factors behind sickle cell disease. (
  • This includes fetal hemoglobin, which protects an infant from sickle cell disease for the first six months after birth. (
  • Mobilized peripheral blood haematopoietic progenitor cells are increasingly being used as against bone marrow (BM) transplants, following high dose chemotherapy and/or radiotherapy for the management of chemosensitive malignancies. (
  • Addition of interleukin-3 (IL-3), stem cell factor (c-kit ligand) and PIXY-321 appear to open-up new vistas by enforcing trilineage and multilineage haematopoietic reconstitution. (
  • CD34-Selected Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Relapsed, High-Risk Multiple Myeloma. (
  • Background and objectives AKI is a major complication of allogeneic hematopoietic stem cell transplantation, increasing risk of nonrelapse mortality. (
  • The use of allogeneic hematopoietic stem cell transplantation continues to increase worldwide ( 1 ), with improving overall outcomes ( 2 ). (
  • Early immune surveillance to predict cytomegalovirus outcomes after allogeneic hematopoietic stem cell transplantation Jintao Xia, et al. (
  • Safety profile of oral netupitant/palonosetron in hematopoietic stem cell transplantation recipients. (
  • The recommendations are expected to promote the wider dissemination and use of the EDQM guides, thus ensuring improved health protection for recipients of organs, tissues or cells in Europe. (
  • Multiple clusters of infection associated with allograft transplantation and poor outcomes have been described for recipients. (
  • External Evaluation of Population Pharmacokinetic Models of Busulfan in Chinese Adult Hematopoietic Stem Cell Transplantation Recipients. (
  • Bacterial bloodstream infections in pediatric allogeneic hematopoietic stem cell recipients before and after implementation of a central line-associated bloodstream infection protocol: A single-center experience. (
  • WEST PALM BEACH, Florida - Stem cell transplantation is tied to complete elimination of relapse in patients with aggressive multiple sclerosis (MS), new long-term data show. (
  • The purpose of this study is to assess the safety and effectiveness of combining pembrolizumab immunotherapy with standard chemotherapy drugs and autologous stem cell transplantation (ASCT) in patients with Hodgkin lymphoma that has come back or continued to grow despite one regimen of prior therapy. (
  • Despite repeated past predictions that better nontransplant approaches would eliminate the need for transplantation in most patients, its use in AML has increased and results have steadily improved with time. (
  • [ 84 ] Improved identification of closely matched unrelated donors, modifications of myeloablative preparation and reduced intensity regimens now make transplantation safely available to more patients. (
  • Better differential prognostic factors more reliably identify patients in first remission who should be treated with transplantation. (
  • High-resolution genomic techniques can identify previously unrecognized relevant genetic lesions, [ 85 ] which will further assist in selection of patients for transplantation. (
  • Transplantation appears destined to provide the most effective curative therapy for many patients with AML in the foreseeable future. (
  • For some patients who are in remission and can tolerate intensive chemotherapy, the doctor may recommend stem cell transplantation during the consolidation phase of chemotherapy. (
  • Research to determine which patients are most likely to benefit from stem cell transplantation after their first complete remission is evolving. (
  • Studies show that allogeneic stem cell transplantation may benefit patients with high-risk and intermediate-risk AML up to age 75 years and who have an HLA-matched donor. (
  • Allogeneic stem cell transplantation, compared to other treatment approaches, is associated with a higher rate of side effects and mortality in patients. (
  • Autologous transplantation is sometimes used for patients who do not have an HLA-matched donor. (
  • This is because patients receive their own stem cells, so the risk of some complications, such as graft-versus-host disease, is lower. (
  • Autologous transplants are used less frequently than allogeneic transplants for AML patients mainly because of the lack of a graft-versus-leukemia effect and the risk of returning some leukemia cells back to the patient. (
  • Patients with blood diseases like leukemia and lymphoma often require bone marrow transplants to replace the diseased cells with healthy immune cells. (
  • In this study, the effect of intrathecal administration of autologous bone marrow mononuclear cells (BMMNCs) is analyzed on the recovery process of patients with chronic stroke. (
  • 24 patients diagnosed with chronic stroke were administered cell therapy, followed by multidisciplinary neurorehabilitation. (
  • Patients who underwent cell therapy within 2 years after the stroke showed better changes. (
  • 2021) showed that faecal microbiota transplantation stops the decline in endogenous insulin production in newly diagnosed type 1 diabetes patients. (
  • In this study, the investigators aim to investigate whether beta cell mass (quantified by 68Ga-NODAGA-exendin-4 PET/CT imaging) is correlated to beta cell function after autologous faecal microbial transplantation in patients with newly diagnosed type 1 diabetes. (
  • Beta cell-replacement therapy has shown enormous promise for T1D patients. (
  • To prevent the immune system from attacking the replacement cells, immunosuppressants are necessary, but they can be toxic and leave patients vulnerable to malignancies and other infections. (
  • According to a recent article published in the journal Blood , high-dose chemotherapy and autologous stem cell transplantation as initial therapy produces a complete disappearance of cancer in a significant number of patients with advanced follicular lymphoma. (
  • Researchers from Italy recently conducted a clinical trial involving 20 medical centers to evaluate the effectiveness and safety of high-dose chemotherapy and autologous stem cell transplantation in 92 patients with previously untreated advanced follicular lymphoma. (
  • Nearly 40% of patients were treated at small institutions that performed 31 or few autologous stem cell transplants per year for blood-related cancers. (
  • These researchers concluded that high-dose chemotherapy with autologous stem cell transplantation is an effective and safe treatment option for patients younger than 60 years with poor prognosis advanced follicular lymphoma, even in facilities that perform few transplants per year. (
  • The newly announced program, designed by Harvard Stem Cell Institute (HSCI), Brigham and Women's Hospital (BWH) and the Joslin Diabetes Center (JDC), in collaboration with Semma Therapeutics (Semma) and Dana-Farber Cancer Institute (DFCI), will work toward translating these stem cell discoveries into treatments that could ultimately cure diabetic patients. (
  • The initial clinical trial will enroll a very small, very select group of patients - individuals who have had their pancreas surgically removed because they had intractable pancreatitis or similar conditions and who have not shown signs of islet autoimmunity (the body attacking its own insulin-producing cells). (
  • The program is intended to uniquely leverage the stem cell and beta cell capabilities along with the clinical expertise and resources of the participating institutions to bring a novel therapy rapidly to patients. (
  • In the next phase, the cell production facility at DFCI will derive stem cells from patients and manufacture the beta cell products using Semma's differentiation protocol. (
  • BWH will perform the transplantation procedure and patients will be followed by both BWH and JDC. (
  • This project builds on our pioneering work in transplantation and exemplifies the Brigham's commitment to fostering discovery and innovation in order to translate research advancements into new therapies and treatments for our patients," said Betsy Nabel, MD, president of Brigham and Women's Health Care. (
  • In January, Keith M. Sullivan, MD, professor of medicine at Duke University Medical Center in Durham, N.C., and colleagues reported in the New England Journal of Medicine that myeloablative autologous hematopoietic stem cell transplantation resulted in long-term benefits for patients with severe scleroderma. (
  • Patients in the trial, Scleroderma: Cyclophosphamide or Transplantation (SCOT), experienced improved event-free and overall survival. (
  • Dr. Sullivan and colleagues are particularly interested in this subset of patients and think the benefits of stem cell treatment outweigh its risks for these patients. (
  • The SCOT trial enrolled patients with severe scleroderma who had severe internal organ disease (as opposed to solely skin disease) and treated them with myeloablative therapy followed by CD34+ selected autologous hematopoietic stem cell transplantation . (
  • This case study demonstrates how oncology nurses play a critical role in patients' journeys before and after autologous stem cell transplantation. (
  • Solid organ transplantation (SOT) and hematopoietic cell transplantation (HCT) have dramatically improved the survival and quality of life in patients with a variety of malignancies and chronic end - organ disease. (
  • In multivariate analysis, patients receiving the higher cell dose had a significantly better disease-free survival (relative risk 2.17, P = .045). (
  • 1 The higher toxic death rate and poorer disease-free survival in patients receiving ≤2 × 10 8 nucleated cells/kg was only partially due to incomplete or delayed hematopoietic reconstitution with resultant increase in bleeding or infections because the cell dose did not affect the probability or rapidity of engraftment significantly in this group of 74 patients. (
  • Because macrocytosis usually precedes a low platelet count , patients with typical congenital anomalies associated with FA should be evaluated for an elevated red blood cell mean corpuscular volume . (
  • EPITA is established to provide a forum for those working in the field of pancreas and islet of Langerhans transplantation or any other alternative form of beta cell replacement in Europe, to exchange scientific information and views related primarily to providing the best service for patients in Europe requiring pancreas or islet transplantation. (
  • Bortezomib Maintenance After Allogeneic Transplantation in Newly Diagnosed Myeloma Patients Results in Decreased Incidence and Severity of Chronic GVHD. (
  • Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (
  • The introduction of reduced-intensity conditioning (RIC) regimens made it possible to offer allogeneic hematopoietic cell transplantation (alloHCT) to older patients with myelodysplastic syndromes (MDS). (
  • At the Hospital General Universitario Gregorio Marañon, in Madrid, our research on cord blood transplants is focused on ways to combine cord blood stem cells with other donated stem cells so that patients will receive a full cell dose and will have faster engraftment. (
  • In this way we hope to push back the frontier of cord blood transplantation, and make the procedure both safer and available to more patients. (
  • Our group has developed a strategy called "dual" or "haplo-cord" transplants: patients receive stem cells from a single cord blood unit combined with stem cells from the bone marrow of a donor who is "haploidentical" to the patient. (
  • The stem cells subsequently can be utilized in transplants for patients suffering from life-threatening blood-related diseases such as leukemia and other cancers. (
  • ASt/AJT Journal Club on "Simultaneous pancreas-kidney transplantation in Caucasian versus African American patients. (
  • As anticipated, poor serologic responses have been particularly observed among patients receiving B-cell depleting therapies. (
  • Case reports describe successful liver transplantation in patients with severe progressive liver failure due to pyruvate kinase deficiency. (
  • The purpose of this guideline is to maximise the safety of patients who need haemopoietic stem cell transplantation and make the best use of NHS resources, while protecting staff from infection. (
  • Hypochromic Red Cells and Survival in Systemic Sclerosis What could the presence of hypochromic red cells tell us about survival in patients with systemic sclerosis? (
  • The process involves extraction of a patient's stem cells, followed by a conditioning regimen with high-dose chemotherapy to deplete immune cells and then infusion of stem cells back into the patient to establish a less-reactive immune response. (
  • During ASCT, a patient's own blood-forming stem cells are collected, and he or she is then treated with high doses of chemotherapy. (
  • First the patient receives intensive chemotherapy, with or without radiation, to kill the remaining leukemic cells in the patient's body. (
  • This also destroys the normal stem cells in the patient's bone marrow. (
  • The goal is to have the donor stem cells become established in the patient's bone marrow and produce white blood cells that will attack the patient's remaining cancer cells. (
  • The cells are returned to the patient's body after receiving intensive chemotherapy. (
  • Hematopoietic cells can be obtained from suitably matched related or unrelated volunteer donors (allogeneic HCT) or from the patient's own tissues (autologous HCT). (
  • Likewise, the long-term results of autologous HCT are strongly influenced by the amount of cancer in the patient's body at the time of transplantation, with relapse being the leading cause for treatment failure. (
  • Stem cell transplantation for Hodgkin's disease usually involves harvesting the patient's stem cells, from the bone marrow or blood, rather than from a donor. (
  • The disease develops when the patient's immune system attacks its own beta cells, which make insulin in the pancreas. (
  • The value of tandem autologous stem cell transplantation is worthy of further discussion, which should consider various aspects such as the transplantation medication regimen and the patient's state. (
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (
  • This means that the patient's own cells from disease-spared areas could be used to repair destroyed ducts. (
  • But the biggest disadvantage of cord blood transplants is that it takes longer for the stem cells from cord blood donations to "engraft", so that the patient's immune system recovers. (
  • Haplo-cord transplants have been shown to reduce the patient's engraftment time, because the haploidentical donor cells engraft faster than the cord blood cells. (
  • The transplantation was performed successfully on June 18, saving the Belgian patient's life. (
  • In one case zinc finger nucleases were used to delete the CCR5 gene in a patient's cells, a procedure that we discussed in TWiV #278 . (
  • In stem cell transplantation, doctors replace a patient's bone marrow with stem cells from a healthy, fully-matched donor (usually a sibling). (
  • For each of these therapies, chemotherapy drugs are given first to rid the body of the cancer cells. (
  • Although there are multiple lines of available therapies and ongoing clinical trials, autologous stem cell transplantation remains the central option for prolonging durations of remission and improving overall survival. (
  • The present report aims to provide a comprehensive analysis of the current situation and facilitate a forward-looking discussion on actions for improving access to transplantation therapies. (
  • The Sarthy Lab seeks to improve the lives of children with cancer by studying the fundamental mechanisms cancer cells use to evade therapies and develop resistance. (
  • By focusing on chromatin, the mix of proteins and DNA that are found in cells ranging from yeast to fruit flies to humans, we will understand how cancers form and identify safer ways to kill cancer cells while minimizing side effects of these often toxic therapies. (
  • The mission of ECTORS is to provide a forum for discussing and stimulating novel developments in the fields of cellular therapies in organ transplantation, organ regeneration and generation of new organs from stem cells and biomaterials. (
  • Cell-based therapies could provide an advantageous alternative, but the development of these new therapies is often impaired and delayed by the lack of an appropriate model to test their safety and efficacy in humans before embarking in clinical trials. (
  • Embryonic stem cell (ESC) differentiation has the potential to be instrumental in cell based therapies and in vitro disease modeling and chemical screens. (
  • Therefore, successful in vitro differentiation protocols to be applied either for cell based therapies or disease modeling should produce neurons with defined generic and subtype identity. (
  • With intellectual property for human cord blood as a source of stem cells, Saneron is committed to providing readily available, non-controversial, ethically acceptable cells, both stem cells and other cell types, for cellular therapies. (
  • PLEASE NOTE: Due to the large number of enquiries competing for limited time, Dr Muraro regrets he is unable to reply to emails or phone calls from individuals seeking advice on therapies, stem cell treatments or participation in clinical trials. (
  • The cells are attacked because the immune system recognizes them as harmful invaders instead of helpful therapies. (
  • Gene and cell therapies present novel alternatives to disease management, offering the promise of a single treatment and a lifelong cure. (
  • The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (
  • After the chemotherapy, the patient receives an infusion of stem cells to replace the stem cells destroyed by the intensive therapy. (
  • The chemotherapy kills healthy cells as well. (
  • Treatment for follicular lymphoma includes chemotherapy, radiation therapy, stem cell transplantation and/or biologic therapy (treatment used to stimulate the immune system to fight cancer). (
  • High-dose chemotherapy tends to kill more cancer cells than conventional chemotherapy. (
  • One serious side effect that is common with the treatment of high doses of chemotherapy involves the suppression of blood cells. (
  • The high doses of chemotherapy can kill the stem cells in the bone marrow and leave blood cell levels depleted. (
  • Autologous peripheral blood stem cell transplantation, which attempts to eradicate minimal residual disease with myeloablative chemotherapy and rescue by autologous stem cells (collected from peripheral blood in the previous treatment procedure) to restore bone marrow function, has been included in the standard treatment regimen of high-risk neuroblastoma. (
  • To determine the efficacy and toxicity of chemoimmunotherapy followed by either whole-brain radiotherapy (WBRT) or intensive chemotherapy and autologous stem-cell transplantation (ASCT) as a first-line treatment of primary CNS lymphoma (PCNSL). (
  • When the disease did not respond to chemotherapy, Brown underwent stem cell transplantation, which involves treatment with cytotoxic drugs and whole-body irradiation to destroy leukemic and immune cells, followed by administration of donor stem cells to restore the immune system. (
  • The efficacy and tolerability of combining pemetrexed-based chemotherapy with gefitinib in the first-line treatment of non-small cell lung cancer with mutated EGFR: A pooled analysis of randomized clinical trials. (
  • While transplantation research continues to focus on the development of Treg-sparing and plasma cell/B-cell-targeting strategies to improve long-term outcomes, little attention has been paid to the emerging role of the TH17 cell in mediating chronic rejection. (
  • Evolution, trends, outcomes, and economics of hematopoietic stem cell transplantation in severe autoimmune diseases. (
  • Outcomes of corneal transplantation in Europe: report by the European Cornea and Cell Transplantation Registry. (
  • ABSTRACT Organ transplantation must be viewed in relation to the prevailing cultural, religious and socio-economic conditions of a nation. (
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (
  • Pembrolizumab blocks PD-1, a protein cancer cells use to evade detection by the immune system, thereby enabling the immune system to find and kill cancer cells. (
  • The new immune system also has the potential to recognize and attack any remaining cancer cells. (
  • The transplanted immune cells (the graft) perceive the leukemia cells in the body as foreign and destroy them. (
  • This important accomplishment would not have been possible without decades of intense pre-clinical research in animals, especially to understand issues related to graft rejection and the prevention of graft-versus-host disease (GVHD), a serious reaction caused by the donor's immune cells attacking the recipient's vital organs. (
  • The immunosuppressive regimens currently used in transplantation to prevent allograft destruction by the host's immune system have deleterious side effects and fail to control chronic rejection processes. (
  • Interestingly, considerable insight into these mechanisms was obtained through transplantation models and by manipulating the development of the immune system early in life, during embryogenesis or in neonates. (
  • However, replacement beta cells don't live long, and the immune system often rejects the ones that do survive. (
  • The authors noted that embryonic stem cells have previously been identified as promising candidates for transplantation, however they have also been associated with immune rejection and ethics issues. (
  • Hematopoietic cell transplantation (HCT) involves the intravenous (IV) infusion of allogeneic (donor) or autologous stem cells to reestablish hematopoietic function in individuals whose bone marrow or immune system is damaged or defective. (
  • Autologous transplantation was found to produce almost no immune reaction and to result in viable neural cells. (
  • By contrast, allogeneic transplantation provoked immune reaction by microglia and lymphocytes. (
  • If autologous transplantation could allow immune reaction to be avoided, it would also make unnecessary the use of immunosuppressant drugs and avert the risk of side-effects caused by immunosuppression. (
  • However, the studies of iPS cell-based autologous transplantation carried out so far, which have used a mouse model, have produced no firm conclusion, with immune reaction observed in some studies but not in others. (
  • This study by Dr. Takahashi's group sought to clarify this area by transplanting dopaminergic neurons prepared from iPS cells into the brains of cynomolgus monkeys and comparing the extent of immune reaction between autologous and allogeneic transplantation. (
  • The study data show that, in primates, autologous transplantation of iPS cell-derived neural cells produces almost no immune reaction and is superior to allogeneic transplantation in terms of immune reaction control and cell viability. (
  • Regulatory T cells (Treg) regulate immune responses by suppressing effector T cells. (
  • Scientists are able to generate pancreatic cells from stem cells in the lab, and they can be transplanted to someone who has lost pancreatic function, but they'll be reattacked by the immune system," says Juan-Carlos Zúñiga-Pflücker , senior scientist at Sunnybrook Research Institute and professor of immunology in the Temerty Faculty of Medicine. (
  • Not only is diabetes an autoimmune disease, where the diabetic's own immune system attacks and kills insulin producing cells, but attempts to replace the lost cells with transplanted cells are also challenged by other impacts of the disease, as well as the presence of auto-reactive immune cells," he says. (
  • d) the Minister has reason to believe that the establishment is not in compliance with these Regulations or that the safety of cells, tissues or organs has been or could be compromised. (
  • It has been proposed that bone marrow or hematopoietic stem-cell transplantation, and resulting (mixed) hematopoietic chimerism, lead to immunological tolerance to organs of the same donor. (
  • During lymphocyte development in primary lymphoid organs, and due to the random rearrangement of genes encoding the antigen receptor, many autospecific T and B cell precursors arise. (
  • The Committee of Ministers of the Council of Europe has adopted two new recommendations, 1 calling on member states to ensure that quality and safety standards for the donation and transplantation or human application of organs, tissues and cells are respected in accordance with the technical guides 2 published by the European Directorate for the Quality of Medicines & HealthCare (EDQM) of the Council of Europe. (
  • Standards and guidelines on the quality and safety of organs, tissues and cells of human origin for transplantation have been published by the EDQM since 2002 and are now recognised worldwide as reference documents in the field. (
  • 1. Recommendation CM/Rec(2020)4 on the quality and safety of organs for transplantation , and Recommendation CM/Rec(2020)5 on the quality and safety of tissues and cells for human application . (
  • Transplantation of organs and tissues is increasing ( Figure ). (
  • The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (
  • In June 2018, the Secretariat established the WHO Task Force on Donation and Transplantation of Human Organs and Tissues as an advisory group composed of experts from all WHO regions. (
  • Human organ transplantation, involving the therapeutic use of organs obtained from healthy living or deceased donors, is the last resort for the survival and well-being of thousands of men, women and children suffering from end-stage organ failure [1,2]. (
  • This approach could be applied to other organs and diseases to accelerate the clinical application of cell-based therapy. (
  • Given the chronic shortage of donor organs, it's important to look at ways of repairing damaged organs, or even provide alternatives to organ transplantation," said Fotios Sampaziotis of the Wellcome-MRC Cambridge Stem Cell Institute. (
  • 2. The surgical transfer of cells, tissues, or especially whole organs from one species to another. (
  • The rationale for xenotransplantation is the short supply of human organs for transplantation. (
  • It is published by Wiley-Blackwell Publishing Ltd . The overall rank of American Journal of Transplantation is 506 . (
  • The ISSN of American Journal of Transplantation journal is 16006135, 16006143 . (
  • American Journal of Transplantation is cited by a total of 9110 articles during the last 3 years (Preceding 2021). (
  • American Journal of Transplantation IS is increased by a factor of 2.71 and approximate percentage change is 62.73% when compared to preceding year 2020, which shows a rising trend. (
  • IS 2021 of American Journal of Transplantation is 7.03 . (
  • Year wise Impact Score (IS) of American Journal of Transplantation. (
  • Stem Cell Transplantation a Potential Game Changer for MS? (
  • Stem cell infusion is a relatively simple process that is performed at the bedside. (
  • Cite this: Treatment of Acute Myeloid Leukemia With Hematopoietic Stem Cell Transplantation - Medscape - May 01, 2009. (
  • This is the most common type of stem cell transplantation used to treat AML. (
  • Watt, F.M. Stem cell fate and patterning in mammalian epidermis. (
  • Stem cell transplantation is usually only done if Hodgkin's disease recurs. (
  • The funds will support world-class stem cell biologists, immunologists, and bioengineers who are working to overcome significant barriers to beta-cell replacement therapy as an effective treatment for T1D. (
  • Recent studies have indicated the potential of stem-cell based approaches for the regeneration of hair cells and associated auditory primary neurons. (
  • Ito, J. Fates of murine pluripotent stem cell-derived neural progenitors following transplantation into mouse cochleae. (
  • Furthermore, this procedure may be safely performed in clinical centers that perform fewer than 3 autologous stem cell transplants a month. (
  • All blood cells are derived from a common cell called the stem cell, which is produced in the bone marrow. (
  • In addition, it was previously thought that this procedure could only be safely performed in a large institute that performed many stem cell transplants per year. (
  • In year one of this award we completed the major objectives of Aim1, namely to explore the survival, integration, and cell fate of stem cell-derived MGE cell transplants in the uninjured rodent spinal cord. (
  • Cambridge, MA (June 22, 2016) - The Harvard Stem Cell Institute, three of Harvard's clinical affiliates, and a biopharmaceutical company have formed a unique collaboration to establish the Boston Autologous Islet Replacement Program (BAIRT) to accelerate a cure for diabetes. (
  • Recent advancements in stem cell biology have provided an unprecedented opportunity to treat diabetes. (
  • The initial trial will test both the safety of the stem cell derived beta cells and make an initial assessment of their efficacy. (
  • During the first phase of the program, DFCI, HSCI, and Semma will work together in developing and optimizing the stem cell derivation protocol. (
  • Peter Amenta, President of Joslin, said, "One of our highest priorities at Joslin Diabetes Center has been to bring stem cell-based beta cell replacement therapy to people living with diabetes. (
  • The trial demonstrated the durability of the beneficial effects of the stem cell treatment. (
  • This study aimed to analyze the efficacy of autologous peripheral blood stem cell transplantation for high-risk neuroblastoma in China. (
  • In addition, the prognoses of tandem autologous stem cell transplantation and single autologous stem cell transplantation groups were compared. (
  • The results of survival analysis showed that autologous peripheral blood stem cell transplantation based on this pretreatment regimen significantly improved the prognosis of children in the high-risk group. (
  • Based on this pretreatment programme, autologous peripheral blood stem cell transplantation is safe and tolerable and significantly improves the prognosis of children in the high-risk group. (
  • A series of studies on autologous peripheral blood stem cell transplantation have been published, however, these have rarely been conducted in China [ 6 ]. (
  • Since 2010, our centre is the first in China to lead the use of tandem autologous stem cell transplantation for the treatment of high-risk neuroblastoma, the related procedures and conditioning protocols for stem cell collection, storage and reinfusion have been developed and incorporated into the high-risk neuroblastoma standard treatment regimen, known as the Chinese Children's Cancer Group (CCCG) Neuroblastoma (NB)-2015 regimen. (
  • This study, based on 10 years of clinical experience in our centre, retrospectively analyzed the data of high-risk neuroblastomas treated by the CCCG-NB-2015 regimen and summarized the efficacy and safety of autologous peripheral blood stem cell transplantation, including single transplantation and tandem transplantation. (
  • Severe Mucositis Is Associated with Reduced Survival after Autologous Stem Cell Transplantation for Lymphoid Malignancies," British Journal of Haematology, Vol. 135, No. 3, 2006, pp. 374381. (
  • The findings of the study has been published in the US scientific journal Stem Cell Reports on September 26, 2012 (US Eastern time). (
  • In Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (pp. 985-1000). (
  • IMSEAR at SEARO: Blood stem cell transplantation: current concepts. (
  • Kamble R, Raju GM, Kumar L, Kochupillai V. Blood stem cell transplantation: current concepts. (
  • This article presents the results of a research that investigated how the adolescents realize their hospitalization to go through the Hematopoietic Stem Cell Transplantation in the Serviço de Transplante de Medula Óssea of the HC/UFPR. (
  • Poor outcome with hematopoietic stem cell transplantation for bone marrow failure and MDS with severe MIRAGE syndrome phenotype. (
  • To the best of our knowledge, only the transmission of malarial parasites has been reported during stem cell transplantation. (
  • Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (
  • The stem cell mobilization result was poor. (
  • This is the first time that we've been able to show that a human liver can be enhanced or repaired using cells grown in the lab," said Ludovic Vallier from the Wellcome-MRC Cambridge Stem Cell Institute. (
  • Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons. (
  • The company's patented technology includes U-CORD-CELL from umbilical cord blood, which is a stem cell technology, as well as SERT-CELL from Sertoli cells. (
  • His research programme is funded by the Medical Research Council, the UK Multiple Sclerosis Society, the UK Stem Cell Foundation, the Wellcome Trust, and the Italian Multiple Sclerosis Society. (
  • Los Angeles, June 19, 2010 - The Armenian Bone Marrow Donor Registry (ABMDR) announced that, for the first time in the history of Armenia and the Caucasus region, it has performed a stem cell harvesting procedure in Yerevan. (
  • Dr. Jordan continued: "The procedure is also an outstanding achievement for Armenia, which is already being recognized as an important international center for stem cell harvesting. (
  • The stem cell harvesting procedure in Yerevan was performed on June 16, at the ABMDR's Stem Cell Harvesting Center, collecting stem cells from a healthy donor. (
  • The procedure, which is painless and non-intrusive, was supervised by doctors Andranik Meshetsian and Mihran Nazaretyan of the Stem Cell Harvesting Center. (
  • Once the procedure was completed and qualitative and quantitative lab tests verified that the harvesting was conducted in accordance with international standards, the stem cell harvest was entrusted to a specialist courier who had traveled to Yerevan for this purpose. (
  • The Stem Cell Harvesting Center in Yerevan was established in April 2009, with support from individual and corporate sponsors and grass-roots contributions from throughout the worldwide Armenian community. (
  • In addition to recruiting bone marrow donors, these events will seek support for the establishment of a stem cell transplantation center in Armenia and the creation of support groups in Australia, Egypt, France, Latin America, and Russia. (
  • Established in 1999, the ABMDR, a nonprofit organization, helps Armenians worldwide survive life-threatening blood-related illnesses by recruiting and matching donors to those requiring bone marrow stem cell transplants. (
  • Legislation reauthorizing the Stem Cell Therapeutic and Research Act has been overwhelmingly passed by both the U.S. Senate and House of Representatives. (
  • The only cure is a well-matched stem cell transplantation, but this procedure is not widely available to everyone. (
  • Allogeneic transplantation uses healthy blood-forming cells from an HLA-matched family member, an unrelated donor, or from umbilical cord blood. (
  • Islet cell transplantation transfers cells from an organ donor into the body of another person. (
  • Despite the recognized need to address these challenges, there is little consensus regarding direction for improvements in donor evaluations or for identification of future epidemiologic threats posed by allograft transplantation. (
  • Another advantage of cord blood stem cells is that they can be available in much less time than it takes to activate a registered bone marrow donor. (
  • However, this engraftment is transient, and only acts as a bridge - eventually the stem cells from the cord blood donor take over, replace the haploidentical donor cells, and engraft permanently. (
  • A resident of Iran who is registered with the ABMDR, the donor traveled to Armenia when he received a request to donate stem cells for a patient in Belgium. (
  • As soon as he received the request, our donor, who lives in Iran, didn't think twice to rush to Yerevan and donate stem cells. (
  • Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (
  • There are various clinical trials conducted including animal and human models, which aimed at assessing the effects of cell therapy in stroke. (
  • However, it took an entire century to develop reliable techniques to identify suitable donors, design potent antibiotics, and establish essential supportive care methods to successfully perform clinical hematopoietic cell transplantation (HCT) procedures. (
  • Joslin has a long history of expertise in beta cell research, immunology and novel diabetes clinical trials. (
  • Moreover, these studies did not involve transplantation of differentiated cells derived from iPS cells in a way that mimicked clinical application. (
  • T cell-mediated rejection remains a barrier to the clinical application of islet xenotransplantation. (
  • Pancreatic islet transplantation as a treatment for type 1 diabetes received a major impetus with the development of the Edmonton protocol and recent clinical trials demonstrating long-term insulin independence out beyond 5 years after transplantation ( 1 - 4 ), although encouraging this therapy will always be limited by the relatively small number of organ donors available for islet isolation. (
  • Clinical trials have been conducted to test a variety of strategies in which CD4+ T or stem cells are obtained from a patient, the CCR5 gene is either mutated or its translation blocked by RNA interference, and then the resulting virus-resistant cells are returned to the patient. (
  • Clinical and Genomic Features of HER2 Exon 20 Insertion Mutations and Characterization of HER2 Expression by Immunohistochemistry in East Asian Non-Small-Cell Lung Cancer. (
  • Beta cells make up 50%-70% of the cells in human pancreatic islets - groups of cells in the pancreas that produce blood glucose-regulating hormones - and they are the sole producers of insulin in the body. (
  • HSCI co-director Doug Melton has developed a process to generate virtually unlimited numbers of beta cells - insulin-producing cells found in the pancreas - from stem cells in the lab. (
  • Islets are cells found in clusters throughout the pancreas . (
  • In type 1 diabetes, the beta cells of the pancreas no longer make insulin. (
  • Diabetes is the most common cause of kidney and pancreas transplantation. (
  • This ability to reduce blood sugar levels correlated to ALDHhi cell engraftment in the mouse bone marrow, but not engraftment into the mouse pancreas. (
  • Since such cells would cause devastating autoimmune pathology, the natural mechanisms involved in the induction of self-tolerance play a crucial role in the survival of the species ( Waldmann, 2010 ). (
  • The research team will use the Gordons' investment to help answer two big questions: How can they prolong the survival of replacement beta cells after transplantation? (
  • Researchers in Japan who evaluated the risks and efficacy of transplanting two varieties of stem cells into mouse cochlea have concluded that both adult-derived induced pluripotent stem (iPS) cells and mouse embryonic stem (ES) cells demonstrate similar survival and neural differentiation capabilities. (
  • Consequently, this study compared the survival and neural differentiation capabilities of ES and three clones of mouse iPS cells. (
  • While this study did not look at the ability of the transplanted cells to repair hearing loss, it does provide insight into the survival and fate of transplanted cells. (
  • Also, we initiated histological examination of animals six months post-injection and detected robust human cell survival, dispersal into the spinal cord grey matter, and neuronal maturation, but no evidence of tumor formation. (
  • Our preliminary histological analysis shows robust human cell survival, distribution, and neuronal differentiation, and we have electrophysiological data indicating functional integration of the transplanted cells. (
  • The 3-year event-free survival (EFS) and overall survival (OS) rates for the transplantation group and the nontransplantation group were 65.5% vs. 41.3% ( p =0.023) and 77.1% vs. 57.9% ( p =0.03), respectively. (
  • Kidney transplantation is a far more favourable treatment modality versus dialysis in terms of survival, quality of life and cost-effectiveness. (
  • In the future, both cell types can be the substrate for chemical screens to identify molecules that enhance MN survival. (
  • [ 8 ] Thymus transplantation has shown very promising results with 73% survival in a group of 49 consecutive infants. (
  • High-dose busulfan (BU) followed by high-dose cyclophosphamide (CY) before allogeneic hematopoietic cell transplantation (HCT) has long been used as treatment for hematologic malignancies. (
  • The original proposed mechanism "had really been focused predominantly on the ability to remove the rapidly cycling cells, but now it's focusing more on a potential T reg mechanism," said Jonathan Serody , a professor of microbiology and immunology at the University of North Carolina, Chapel Hill, who was not involved in the work. (
  • Zúñiga-Pflücker and Naoto Hirano , a senior scientist at Princess Margaret Cancer Centre and a professor of immunology at U of T, work on producing regulatory T cells (Tregs). (
  • [ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (
  • T cell-depleted transplants, higher baseline serum albumin, and non-Hispanic ethnicity were associated with lower risk of AKI. (
  • T cell-depleted hematopoietic cell transplants and higher serum albumin had lower risk of AKI. (
  • Mobilization of lymphokine activated killer cells (LAK), use of blood stem cells (BSC) for allogeneic transplants and ex vivo expansion of the mobilized cells are emerging as the future areas for research. (
  • and Sara Nunes Vasconcelos , a scientist at UHN's Toronto General Hospital Research Institute, are using stem cells to generate tissues containing insulin-secreting cells for transplants. (
  • Thus, the availability of and access to human tissues for transplantation remains essential. (
  • There are mounting evidences which support the capacity of bone-marrow derived cells to mobilize from the bone marrow into the peripheral blood, eventually homing into the injured brain. (
  • Those in the blood stream are called peripheral blood stem cells (PBSCs). (
  • Neonatal porcine islet transplanted NOD-SCID IL2rγ −/− mice received human peripheral blood mononuclear cells (PBMC) with in vitro expanded autologous Treg in the absence or presence of anti-human interleukin-10 (IL-10) monoclonal antibody. (
  • Infants with athymia demonstrate a lack of peripheral blood naive T cells (recent athymic emigrants), characterized by the coexpression of CD45RA and CD62L. (
  • Afterward, the collected stem cells are re-infused back into the patient to re-establish the blood-forming system. (
  • These new stem cells restore healthy stem cells in the bone marrow that can form new red blood cells, white blood cells and platelets. (
  • The donated stem cells restore the bone marrow's ability to form new blood cells. (
  • After a central nervous system (CNS) insult like stroke, the quiescent stem cells present in the bone marrow show increased mobilization and migration from their resident bone marrow into the blood circulation as a result of cytokine production from the CNS. (
  • In 1868, two investigators from Prussia and Italy were the first to report that bone marrow generates blood cells in mammals. (
  • This observation was the starting point of intense efforts to replace malfunctioning marrow through the transplantation of blood-forming (hematopoietic) cells in humans. (
  • Sources of hematopoietic cells include the bone marrow, blood, or umbilical cord blood. (
  • Stem cells can mature into blood cells (white blood cells, red blood cells, and platelets), which are often damaged by cancer. (
  • they enter your blood stream and travel to your bone marrow where they replace damaged stem cells and begin to make healthy blood cells. (
  • A , Hematoxylin- eosin-stained sections showed many small blood vessels with reactive endothelial cells ( black arrow ) in the white matter demonstrating cellular and nuclear enlargement as well as mild interstitial edema ( white arrow ). (
  • The central connecting aspect to explain this fact is that all of these tissues are vascularized and that every blood vessel in the body has mesenchymal cells in abluminal locations. (
  • Reduced tumour cell contamination of mobilized blood compared to bone marrow however, has not been substantiated. (
  • Among those affected, the majority develop cancer , most often acute myelogenous leukemia (AML), and 90% develop aplastic anemia (the inability to produce blood cells) by age 40. (
  • Because of the failure of hematologic components- white blood cells , red blood cells , and platelets -to develop, the body's capabilities to fight infection , deliver oxygen, and form clots are all diminished. (
  • Saneron has patented and patent-pending technology relating to our platform technology of: * U-CORD-CELLTM - Umbilical cord blood * SERT-CELLTM - Sertoli cells. (
  • Intrapancreatic delivery of human umbilical cord blood aldehyde dehydrogenase-producing cells promotes islet regeneration. (
  • In a person with type 1 diabetes, the body mistakenly attacks pancreatic cells that produce insulin, a hormone responsible for regulating blood sugar. (
  • Rep. Chris Smith (R-NJ), lead sponsor of the House version of the bill, said, "It remains one of the best kept secrets in America that umbilical cord blood stem cells and adult stem cells in general are curing people of a myriad of terrible conditions and diseases in adults as well as children. (
  • HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (
  • [ 11 ] Total T-cell numbers can reach markedly elevated levels in the blood (over 50 000/mm 3 ) and can be associated with infiltration of the liver and elevated liver enzymes. (
  • People with the disease have abnormal hemoglobin, a protein in red blood cells that carries oxygen in the body. (
  • The red cell sickling and poor oxygen delivery can also cause organ damage over time and anemia, a blood condition which makes you feel tired or weak. (
  • Stem cells are a type of unspecialized cell that can change into a more specialized cell, such as a healthy red blood cell, under certain conditions. (
  • Researchers are also exploring the feasibility of gene editing, an approach that aims to edit the blood-generating stem cells outside the body to correct the sickle cell mutation and then reinsert the corrected stem cells into the bone marrow. (
  • Transplanted islet cells, however, can take over the work of the destroyed cells. (
  • The Nostro and Vasconcelos labs are defining the right conditions that are necessary for generating insulin-producing cells, which are called islet cells. (
  • An active basic science community and an efficient translation of innovation into the clinic are crucial for the future of transplantation medicine. (
  • The Brigham's involvement in the project has grown out of its international reputation as a leader in transplantation research and surgery. (
  • With these guides, the EDQM/Council of Europe supports health professionals and health authorities with the latest scientific information and contributes to making Europe both a world leader in transplantation and a model for international co-operation on the matter. (
  • The donation and transplantation of substances of human origin has a significant impact on health. (
  • This review aimed to summarize the recent emergence of the TH17 and the newly described TH1/17 cell as major players in transplantation and to suggest ways of improving graft outcome through TH17-targeted immunosuppression. (
  • In vitro Treg expansion was a simple and effective strategy for generating autologous Treg and highlighted a potential adoptive Treg cell therapy to suppress antigraft T-cell responses and reduce the requirement for immunosuppression in islet xenotransplantation. (
  • Autologous HCT may be considered medically necessary to consolidate a first remission of mantle cell lymphoma. (
  • Allogeneic HCT is considered experimental/investigational to consolidate a first remission of mantle cell lymphoma and therefore non-covered because the safety and/or effectiveness of this service cannot be established by the available published peer-reviewed literature. (
  • Transplantation is often used to treat end-stage kidney disease. (
  • Bone marrow aspirates were obtained from the iliac crest and were centrifuged with a cell separator during the procedure of TRO. (
  • Opioids are widely used as analgesics for oral mucositis in allogeneic hematopoietic cell transplantation (allo-HCT). (
  • [ 83 ] The natural killer cell alloreactive mechanism involving killer-cell immunoglobin-like receptors can reduce relapse rates in AML. (
  • To consolidate a first CR in individuals with diffuse large B-cell lymphoma, with an age-adjusted International Prognostic Index score that predicts a high- or high-intermediate risk of relapse. (
  • Characterization of the MicroRNA Cargo of Extracellular Vesicles Isolated from a Pulmonary Tumor-Draining Vein Identifies miR-203a-3p as a Relapse Biomarker for Resected Non-Small Cell Lung Cancer. (
  • CD34+ cells are multipotent hematopoietic stem cells also known as endothelial progenitor cells and are useful in regenerative medicine. (
  • Here, we compared human AC133(+) cells and multipotent adult progenitor cells (hMAPC) in a mouse model reminiscent of critical limb ischemia. (
  • Quite how these stem cells promote regeneration will require further assessment, but as we now have the means to amplify and assess large number of functional progenitor cells in vitro, this strategy could develop into an important approach to battle diabetes. (
  • Expanded Hematopoietic Progenitor Cells Reselected for High Aldehyde Dehydrogenase Activity Demonstrate Islet Regenerative Functions. (
  • Researchers revealed that they were able to stimulate the process of neurogenesis in the brain of adult rat or mouse models with Alzheimer's disease (AD) through transplantation of mesenchymal stem cells. (
  • Adult mesenchymal stem cells [MSCs] are multipotent stromal cells that can give rise to several cell types such as bone, muscle, cartilage, fat, and other tissues. (
  • Mesenchymal stem cells are considered an ideal cell source for transplantation. (
  • Like Navy Seals, these mesenchymal stem cells are very specialized, parachuted (injected) into a hostile area, and may well not survive. (
  • Stem cells are collected from the patient either before or sometime during treatment, frozen and re-infused following therapy. (
  • From the past six months of work, we report considerable progress toward our aims of investigating the safety and efficacy of human inhibitory nerve precursor (MGE) cell transplantation for the treatment of spinal cord injury-induced bladder spasticity and neuropathic pain. (
  • The rates of treatment-related death and post-transplantation use of disease-modifying anti-rheumatic drugs (DMARDs) were lower than previous studies of nonmyeloablative transplantation. (
  • Conclusions: We described two case reports of simultaneous surgical treatment for osteonecrosis of the bilateral femoral head using TRO for one hip in combination with transplantation of BMMNCs for the other hip. (
  • Transplantation of BMMNCs may be a beneficial treatment for bone repair in the condition of osteonecrosis. (
  • Organ transplantation is often the best, if not the only, treatment for acute and chronic organ failure. (
  • 2 × 10 8 nucleated cells/kg body weight died of treatment-related toxicity ( P = .047, χ 2 test). (
  • The roles of nurses in hematopoietic cell transplantation for the treatment of leukemia in older adults. (
  • Saneron CCEL Therapeutics Inc. is a biotechnology research company focused on neurological and cardiac cell therapy for the early intervention and treatment of several devastating or deadly diseases lacking adequate treatment options. (
  • Thymus transplantation shows promise for the treatment of athymia in complete DiGeorge anomaly. (
  • At post transplantation day plus 3, antibiotic drug therapy was switched from piperacillin/tazobactam to meropenem. (