A naturally occurring phenomenon where terminally differentiated cells dedifferentiate to the point where they can switch CELL LINEAGES. The cells then differentiate into other cell types.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.
A species in the genus RHADINOVIRUS, subfamily GAMMAHERPESVIRINAE, isolated from patients with AIDS-related and "classical" Kaposi sarcoma.
Large benign, hyperplastic lymph nodes. The more common hyaline vascular subtype is characterized by small hyaline vascular follicles and interfollicular capillary proliferations. Plasma cells are often present and represent another subtype with the plasma cells containing IgM and IMMUNOGLOBULIN A.
A rare neoplasm of large B-cells usually presenting as serious effusions without detectable tumor masses. The most common sites of involvement are the pleural, pericardial, and peritoneal cavities. It is associated with HUMAN HERPESVIRUS 8, most often occurring in the setting of immunodeficiency.
Virus diseases caused by the HERPESVIRIDAE.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
A condition in which there is a change of one adult cell type to another similar adult cell type.
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.

Gastric PDX-1 expression in pancreatic metaplasia and endocrine cell hyperplasia in atrophic corpus gastritis. (1/531)

The homeodomain transcription factor PDX-1 plays a key role in endocrine and exocrine differentiation processes of the pancreas. PDX-1 is also essential for differentiation of endocrine cells in the gastric antrum. The role of PDX-1 in the pathogenesis of endocrine cell hyperplasia and pancreatic metaplasia in corpus and fundus gastritis has not been evaluated. By immunohistochemistry and double-immunofluorescence, we investigated the expression of PDX-1 in 10 tissue specimens with normal human gastric mucosa, nonatrophic and atrophic gastritis and in pancreatic metaplasia, respectively. In normal corpus mucosa and in nonatrophic corpus gastritis, PDX-1 was mainly absent. In pancreatic metaplasia, PDX-1 was found in metaplastic cells and in adjacent gastric glands. In contrast to normal gastric corpus mucosa, PDX-1 could be strongly detected in the cytoplasm of the parietal cells surrounding metaplastic areas. Furthermore, PDX-1 expression was found in hyperplastic endocrine cells and in the surrounding gastric glands in chronic atrophic gastritis. Hyperplastic endocrine cells coexpressed the beta-subunit of the gastric H,K-ATPase. We conclude that PDX-1 represents a candidate switch factor for glandular exocrine and endocrine transdifferentiation in chronic gastritis and that an impaired parietal cell differentiation might play a key role in disturbed gastric morphogenic processes.  (+info)

Gene profile for differentiation of vascular adventitial myofibroblasts. (2/531)

Our previous study demonstrated that TGF-beta1 could induce the differentiation of vascular adventitial fibroblasts (AFs) to myofibroblasts (MFs). The aim of this study was to identify the genes which might be responsible for the cell phenotypic change using genechips. Cultured rat AFs were treated with TGF-beta1 (10 ng/ml) for 0 min, 5 min, 15 min, 2 h, 12 h and 24 h, respectively. Then the cells were gathered to prepare total RNA. We examined TGF-beta1-induced gene expression profiling using Affymetrix oligonucleotide microarrays and analyzed data by GCOS1.2 software. Moreover, expressional similarity was measured by hierarchical clustering. Some of genechip results were confirmed by real-time quantitative RT-PCR. Microarray analysis identified 2121 genes with a 2-fold change or above after TGF-beta1 stimulation. 1318 genes showed a greater than 2-fold increase and 761 genes were reduced 2 folds or more at mRNA levels, whereas a small portion of the total regulated genes (42 genes) displayed dynamically up- and down-regulated pattern. Genes were further segregated for early (peak at 5 min, 15 min and/or 2 h), late (peak at 12 h and/or 24 h), and sustained (2-fold change or above at five time points) temporal response groups according to the time of their peak expression level. Among 1318 up-regulated genes, 333 genes (25.3%) responded rapidly to TGF-beta1 and 159 genes (12.1%) responded in a sustained manner. Most genes (826, 62.6%) were regulated at 12 h or later. For the 761 down-regulated genes, numbers of early and late responsive genes were 335 (44%) and 267 (36.1%), respectively. There were also 159 genes, 19.9% of total down-regulated genes, decreased at five time points treated by TGF-beta1. The results suggested that the gene expressions of secreted phosphoprotein 1 (APP1) and Rho-associated coiled-coil forming kinase 2 (ROCK2) had the same trends as alpha-smooth muscle-actin, a marker of MF differentiation. In addition, the gene expression of potassium voltage-gated channel, Shal-related family and member 2 (KCND2) was up-regulated. Furthermore, it was found that endothelin 1 (EDN1), some complement components, NADPH oxidase 4 (NOX4) and NAD(P)H dehydrogenase, quinone 1 (NQO1) might be involved in MF differentiation. Using microarrary technique, we confirmed some genes that have been identified by other techniques were implicated in MF differentiation and observed new genes involved in this process. Our results suggest that gene expression profiling study is helpful in identifying genes and pathways potentially involved in cell differentiation.  (+info)

Porcine peroxisome proliferator-activated receptor gamma induces transdifferentiation of myocytes into adipocytes. (3/531)

Peroxisome proliferator-activated receptor gamma2 (PPARgamma) is a nuclear transcription factor that regulates adipocyte differentiation and lipogenic genes during adipogenesis. The activity of rodent PPARgamma is regulated by phosphorylation of serine 112. The current experiment was designed to study the ability of porcine PPARgamma to stimulate transdifferentiation of myoblasts to adipocytes by overexpressing wild-type PPARgamma or mutated PPARgamma (serine 112 was mutated to alanine) in mouse myoblast cells. The expression of adipogenic marker genes (adipocyte fatty acid binding protein, lipoprotein lipase, and glycerol-3 phosphate dehydrogenase) in cells stably expressing mutated porcine PPARgamma was greater than in cells with wild-type PPARgamma, indicating that the mutated PPARgamma has greater adipogenic capability than the wild-type PPARgamma. Under treatment with a ligand, both wild-type and mutant porcine PPARgamma-expressing C2C12 myoblasts differentiated into adipocytes in 10 d. The expression of myogenic marker genes (myogenin, myogenic regulatory factor-4) was suppressed in cells transfected with the mutated PPARgamma or wild-type PPARgamma. Moreover, wild-type and mutant PPARgamma were able to inhibit myogenesis without addition of a ligand. Our results suggest that porcine wild-type PPARgamma and mutated PPARgamma can both convert myoblast cells into adipocytes, and also that the ability to transdifferentiate was greater in cells containing the mutated PPARgamma than in cells containing the wild-type PPARgamma. Therefore, the existence of serine 112 in PPARgamma may have a role in regulating adipocyte differentiation.  (+info)

A functional role of Cdx2 in beta-catenin signaling during transdifferentiation in endometrial carcinomas. (4/531)

Nuclear beta-catenin is required for changes in morphology from glandular to morular phenotypes of endometrial carcinoma (Em Ca) cells, with activation of p14(ARF)/p53/p21(Waf1) and alteration of p16(INK4A)/pRb pathways. Having demonstrated previously that the homeodomain transcription factor Cdx2 increases markedly during intestinal epithelial cell differentiation, we have examined its effects in beta-catenin signaling during transdifferentiation of Em Ca cells. In clinical cases, Cdx2 immunoreactivity, along with increased mRNA signals, was found to overlap with nuclear accumulation of beta-catenin and p21(Waf1) in morules, demonstrating an inverse correlation with cell proliferation. In cell lines, over-expression of active form beta-catenin resulted in a significant increase in endogenous Cdx2 expression at both mRNA and protein levels. Furthermore, the Cdx2 promoter was activated by T-cell factor 4 (TCF4) -independent activated beta-catenin, as well as Cdx2 itself, through the region from -39 to +9 bp relative to transcription start site. Cells over-expressing exogenous Cdx2 showed high levels of p21(Waf1) expression due to stabilization of the mRNA status, resulting in significant decrease in the proliferation rate, in contrast to the lack of apparent changes in morphology. Moreover, transfected Cdx2 could inhibit beta-catenin/TCF4-mediated transcriptional activation of target genes, including p14(ARF) and cyclin D1, probably through indirect mechanisms. These data suggest that over-expression of Cdx2 mediated by nuclear beta-catenin and Cdx2 itself can cause an inhibition of Em Ca cell proliferation through up-regulation of p21(Waf1) expression, modulating beta-catenin/TCF4-mediated transcription. We therefore conclude that an association between Cdx2 and beta-catenin signaling may participate in induction of transdifferentiation of Em Ca cells.  (+info)

VEGF-R blockade causes endothelial cell apoptosis, expansion of surviving CD34+ precursor cells and transdifferentiation to smooth muscle-like and neuronal-like cells. (5/531)

Severe pulmonary hypertension (PH) is characterized by complex precapillary arteriolar lesions, which contain phenotypically altered smooth muscle (SM) and endothelial cells (EC). We have demonstrated that VEGF receptor blockade by SU5416 {3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-indolin 2-one} in combination with chronic hypoxia causes severe angioproliferative PH associated with arterial occlusion in rats. We postulate that endothelial-mesenchymal transdifferentiation can take place in the occlusive lesions and that endothelium-derived mesenchymal cells can further differentiate toward a SM phenotype. To examine this hypothesis, we incubated human pulmonary microvascular endothelial cells (HPMVEC) with SU5416 and analyzed these cells utilizing quantitative-PCR, immunofluorescent staining and flow cytometry analysis. In vitro studies in HPMVEC demonstrated that SU5416 suppressed PGI2S gene expression while potently inducing COX-2, VEGF, and TGF-beta1 expression; and caused transdifferentiation of mature vascular endothelial cells (defined by Dil-ac-LDL, Lectin and Factor VIII) to SM-like (as defined by expression of alpha-SM actin) "transitional" cells, coexpressing both endothelial and SM markers. SU5416 expanded the number of CD34 and/or c-kit positive cells and caused transdifferentiation of CD34 positive cells but not negative cells. In conclusion, our data show that SU5416 generated a selection pressure that killed some EC and expanded progenitor-like cells to transdifferentiate to SM-like and neuronal-like cells.  (+info)

Transdifferentiation of peripheral blood mononuclear cells into epithelial-like cells. (6/531)

Bone marrow-derived stem cells have the potential to transdifferentiate into unexpected peripheral cells. We hypothesize that circulating bone marrow-derived stem cells might have the capacity to transdifferentiate into epithelial-like cells and release matrix metalloproteinase-1-modulating factors such as 14-3-3varsigma for dermal fibroblasts. We have characterized a subset of peripheral blood mononuclear cells (PBMCs) that develops an epithelial-like profile. Our findings show that these cells develop epithelial-like morphology and express 14-3-3varsigma and keratin-5, -8 as early as day 7 and day 21, respectively. When compared with control, conditioned media collected from PBMCs in advanced epithelial-like differentiation (cultures on days 28, 35, and 42) increased the matrix metalloproteinase-1 expression in dermal fibroblasts (P +info)

Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation. (7/531)

Magicin, a protein that we isolated earlier as an interactor of the neurofibromatosis 2 protein merlin, was independently identified as MED28, a subunit of the mammalian Mediator complex. Mediator complex is an evolutionarily conserved transcriptional cofactor, which plays an essential role in positive and negative gene regulation. Distinct Mediator subunit composition is thought to contribute to gene regulation specificity based on the interaction of specific subunits with subsets of transcription factors. Here we report that down-regulation of Med28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell (SMC) differentiation. Conversely, overexpression of MED28 represses expression of SMC genes, in concordance with our knockdown data. More importantly, multipotent mesenchymal-derived murine precursors can transdifferentiate into SMCs when Med28 is down-regulated. Our data also show that Med28 functions as a negative regulator of SMC differentiation in concert with other Mediator subunits including Med6, Med8, and Med18 within the Mediator head module. Our results provide strong evidence that MED28 may function as a scaffolding protein by maintaining the stability of a submodule within the head module and that components of this submodule act together in a gene regulatory program to suppress SMC differentiation. The results presented here demonstrate for the first time that the mammalian Mediator subunit MED28 functions as a repressor of SMC differentiation, which could have implications for disorders associated with abnormalities in SMC growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumors.  (+info)

Effects of KGF on alveolar epithelial cell transdifferentiation are mediated by JNK signaling. (8/531)

Rat alveolar epithelial cells (AEC) in primary culture transdifferentiate from a type II (AT2) toward a type I (AT1) cell-like phenotype, a process that can be both prevented and reversed by keratinocyte growth factor (KGF). Microarray analysis revealed that these effects of KGF are associated with up-regulation of key molecules in the mitogen-activated protein kinase (MAPK) pathway. To further explore the role of three key MAPK (i.e., extracellular signal-related kinase [ERK] 1/2, c-Jun N-terminal kinase [JNK] and p38) in mediating effects of KGF on AEC phenotype, primary rat AEC cultivated in minimal defined serum-free medium (MDSF) were treated with KGF (10 ng/ml) from Day 4 for intervals up to 48 hours. Exposure to KGF activated all three MAPK, JNK, ERK1/2, and p38. Inhibition of JNK, but not of ERK1/2 or p38, abrogated the ability of KGF to maintain the AT2 cell phenotype, as evidenced by loss of expression of lamellar membrane protein (p180) and increased reactivity with the AT1 cell-specific monoclonal antibody VIIIB2 by Day 6 in culture. Overexpression of JNKK2, upstream kinase of JNK, increased activation of endogenous c-Jun in association with increased expression of p180 and abrogation of AQP5, suggesting that activation of c-Jun promotes retention of the AT2 cell phenotype. These results indicate that retention of the AT2 cell phenotype by KGF involves c-Jun and suggest that activation of c-Jun kinase may be an important determinant of maintenance of AT2 cell phenotype.  (+info)

Cell transdifferentiation is a process in which one type of differentiated cell transforms into another type of differentiated cell, without going through the stage of pluripotent stem cells. This process involves a series of genetic and epigenetic changes that result in the activation of new genetic programs and repression of old ones, leading to the acquisition of a new cell identity.

Transdifferentiation is a rare event in nature, but it has been induced in the laboratory through various methods such as gene transfer, chemical treatment, or nuclear transplantation. This process has potential applications in regenerative medicine, tissue engineering, and disease modeling. However, it also raises ethical concerns related to the generation of chimeric organisms and the possibility of uncontrolled cell growth.

Cell differentiation is the process by which a less specialized cell, or stem cell, becomes a more specialized cell type with specific functions and structures. This process involves changes in gene expression, which are regulated by various intracellular signaling pathways and transcription factors. Differentiation results in the development of distinct cell types that make up tissues and organs in multicellular organisms. It is a crucial aspect of embryonic development, tissue repair, and maintenance of homeostasis in the body.

Kaposi sarcoma (KS) is a type of cancer that causes abnormal growths in the skin, lymph nodes, or other organs. It is caused by the Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8). There are several forms of KS, including:

1. Classic KS: This form primarily affects older men of Mediterranean, Middle Eastern, or Ashkenazi Jewish descent. It tends to progress slowly and mainly involves the skin.
2. Endemic KS: Found in parts of Africa, this form predominantly affects children and young adults, regardless of their HIV status.
3. Immunosuppression-associated KS: This form is more aggressive and occurs in people with weakened immune systems due to organ transplantation or other causes.
4. Epidemic KS (AIDS-related KS): This is the most common form of KS, seen primarily in people with HIV/AIDS. The widespread use of antiretroviral therapy (ART) has significantly reduced its incidence.

KS lesions can appear as red, purple, or brown spots on the skin and may also affect internal organs such as the lungs, lymph nodes, or gastrointestinal tract. Symptoms vary depending on the location of the lesions but often include fever, fatigue, weight loss, and swelling in the legs or abdomen. Treatment options depend on the extent and severity of the disease and may involve local therapies (e.g., radiation, topical treatments), systemic therapies (e.g., chemotherapy, immunotherapy), or a combination of these approaches.

Medical Definition of "Herpesvirus 8, Human" (HHV-8):

Human Herpesvirus 8 (HHV-8), also known as Kaposi's Sarcoma-associated Herpesvirus (KSHV), is a DNA virus from the family of Herpesviridae. It is the causative agent of several malignancies, including Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). HHV-8 is primarily transmitted through saliva, sexual contact, or organ transplantation. In immunocompromised individuals, such as those with HIV/AIDS, the risk of HHV-8-associated malignancies significantly increases. The virus establishes latency in infected cells and can periodically reactivate, causing inflammation and potentially leading to the development of cancer.

Giant lymph node hyperplasia, also known as Castlemans disease, is a rare benign condition characterized by the abnormal enlargement of lymph nodes due to an overgrowth of cells. It can affect people of any age but is more commonly seen in young adults and children.

The enlarged lymph nodes caused by this condition are typically round, firm, and mobile, and they may be found in various locations throughout the body, including the neck, chest, abdomen, and pelvis. In some cases, the enlarged lymph nodes may cause symptoms such as pain, pressure, or difficulty swallowing, depending on their location.

Giant lymph node hyperplasia can be classified into two main types: unicentric and multicentric. Unicentric Castleman's disease affects a single group of lymph nodes, while multicentric Castleman's disease affects multiple groups of lymph nodes throughout the body.

The exact cause of giant lymph node hyperplasia is not fully understood, but it is thought to be related to an overactive immune response. In some cases, it may be associated with viral infections such as HIV or HHV-8. Treatment for this condition typically involves surgical removal of the affected lymph nodes, along with medications to manage any associated symptoms and prevent recurrence.

Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma that typically presents as an effusion (accumulation of fluid) in the pleural, pericardial, or peritoneal cavities without a detectable tumor mass. It is strongly associated with the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) and often occurs in people with weakened immune systems, such as those with HIV/AIDS. The malignant cells in PEL are typically large B-cells that secrete fluid, leading to the formation of effusions. This type of lymphoma is aggressive and has a poor prognosis.

Herpesviridae infections refer to diseases caused by the Herpesviridae family of double-stranded DNA viruses, which include herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), human herpesvirus 7 (HHV-7), and human herpesvirus 8 (HHV-8). These viruses can cause a variety of clinical manifestations, ranging from mild skin lesions to severe systemic diseases.

After the initial infection, these viruses typically become latent in various tissues and may reactivate later in life, causing recurrent symptoms. The clinical presentation of Herpesviridae infections depends on the specific virus and the immune status of the host. Common manifestations include oral or genital ulcers (HSV-1 and HSV-2), chickenpox and shingles (VZV), mononucleosis (CMV), roseola (HHV-6), and Kaposi's sarcoma (HHV-8).

Preventive measures include avoiding close contact with infected individuals during the active phase of the infection, practicing safe sex, and avoiding sharing personal items that may come into contact with infectious lesions. Antiviral medications are available to treat Herpesviridae infections and reduce the severity and duration of symptoms.

B-lymphocytes, also known as B-cells, are a type of white blood cell that plays a key role in the immune system's response to infection. They are responsible for producing antibodies, which are proteins that help to neutralize or destroy pathogens such as bacteria and viruses.

When a B-lymphocyte encounters a pathogen, it becomes activated and begins to divide and differentiate into plasma cells, which produce and secrete large amounts of antibodies specific to the antigens on the surface of the pathogen. These antibodies bind to the pathogen, marking it for destruction by other immune cells such as neutrophils and macrophages.

B-lymphocytes also have a role in presenting antigens to T-lymphocytes, another type of white blood cell involved in the immune response. This helps to stimulate the activation and proliferation of T-lymphocytes, which can then go on to destroy infected cells or help to coordinate the overall immune response.

Overall, B-lymphocytes are an essential part of the adaptive immune system, providing long-lasting immunity to previously encountered pathogens and helping to protect against future infections.

Metaplasia is a term used in pathology to describe the replacement of one differentiated cell type with another differentiated cell type within a tissue or organ. It is an adaptive response of epithelial cells to chronic irritation, inflammation, or injury and can be reversible if the damaging stimulus is removed. Metaplastic changes are often associated with an increased risk of cancer development in the affected area.

For example, in the case of gastroesophageal reflux disease (GERD), chronic exposure to stomach acid can lead to metaplasia of the esophageal squamous epithelium into columnar epithelium, a condition known as Barrett's esophagus. This metaplastic change is associated with an increased risk of developing esophageal adenocarcinoma.

A zebrafish is a freshwater fish species belonging to the family Cyprinidae and the genus Danio. Its name is derived from its distinctive striped pattern that resembles a zebra's. Zebrafish are often used as model organisms in scientific research, particularly in developmental biology, genetics, and toxicology studies. They have a high fecundity rate, transparent embryos, and a rapid development process, making them an ideal choice for researchers. However, it is important to note that providing a medical definition for zebrafish may not be entirely accurate or relevant since they are primarily used in biological research rather than clinical medicine.

Zebrafish proteins refer to the diverse range of protein molecules that are produced by the organism Danio rerio, commonly known as the zebrafish. These proteins play crucial roles in various biological processes such as growth, development, reproduction, and response to environmental stimuli. They are involved in cellular functions like enzymatic reactions, signal transduction, structural support, and regulation of gene expression.

Zebrafish is a popular model organism in biomedical research due to its genetic similarity with humans, rapid development, and transparent embryos that allow for easy observation of biological processes. As a result, the study of zebrafish proteins has contributed significantly to our understanding of protein function, structure, and interaction in both zebrafish and human systems.

Some examples of zebrafish proteins include:

* Transcription factors that regulate gene expression during development
* Enzymes involved in metabolic pathways
* Structural proteins that provide support to cells and tissues
* Receptors and signaling molecules that mediate communication between cells
* Heat shock proteins that assist in protein folding and protect against stress

The analysis of zebrafish proteins can be performed using various techniques, including biochemical assays, mass spectrometry, protein crystallography, and computational modeling. These methods help researchers to identify, characterize, and understand the functions of individual proteins and their interactions within complex networks.

According to the National Institutes of Health (NIH), stem cells are "initial cells" or "precursor cells" that have the ability to differentiate into many different cell types in the body. They can also divide without limit to replenish other cells for as long as the person or animal is still alive.

There are two main types of stem cells: embryonic stem cells, which come from human embryos, and adult stem cells, which are found in various tissues throughout the body. Embryonic stem cells have the ability to differentiate into all cell types in the body, while adult stem cells have more limited differentiation potential.

Stem cells play an essential role in the development and repair of various tissues and organs in the body. They are currently being studied for their potential use in the treatment of a wide range of diseases and conditions, including cancer, diabetes, heart disease, and neurological disorders. However, more research is needed to fully understand the properties and capabilities of these cells before they can be used safely and effectively in clinical settings.

Developmental gene expression regulation refers to the processes that control the activation or repression of specific genes during embryonic and fetal development. These regulatory mechanisms ensure that genes are expressed at the right time, in the right cells, and at appropriate levels to guide proper growth, differentiation, and morphogenesis of an organism.

Developmental gene expression regulation is a complex and dynamic process involving various molecular players, such as transcription factors, chromatin modifiers, non-coding RNAs, and signaling molecules. These regulators can interact with cis-regulatory elements, like enhancers and promoters, to fine-tune the spatiotemporal patterns of gene expression during development.

Dysregulation of developmental gene expression can lead to various congenital disorders and developmental abnormalities. Therefore, understanding the principles and mechanisms governing developmental gene expression regulation is crucial for uncovering the etiology of developmental diseases and devising potential therapeutic strategies.

... granulosa and thecal cells → functional Sertoli-like and Leydig-like cells (-Foxl1) Transdifferentiation Induced stem cells ... A list of examples of in vivo transdifferentiation through transfection: mouse hepatocytes → B cells (Pdx1) exocrine cells → B ... Generating Desired Cell Types from Abundant and Accessible Cells". Stem Cells. 29 (12): 1933-1941. doi:10.1002/stem.760. PMID ... Cell. 139 (6): 1130-1142. doi:10.1016/j.cell.2009.11.021. PMID 20005806. (Histology, Induced stem cells). ...
Glial cells → neurons (Pax6) Erythorid-megakaryocytic cells → monocytic cells (SPI1/PU.1) B-cell progenitors → functional ... Generating Desired Cell Types from Abundant and Accessible Cells". Stem Cells. 29 (12): 1933-1941. doi:10.1002/stem.760. PMID ... A list of examples of transdifferentiation: Mouse fibroblasts, chondroblasts, and pigmented retinal epithelial cells → ... Xie, H.; Ye, M.; Feng, R.; Graf, T. (2004). "Stepwise reprogramming of B cells into macrophages". Cell. 117 (5): 663-676. doi: ...
... neural stem/progenitor cells (Oct4, Sox2, c-Myc, Klf4) Transdifferentiation Induced stem cells Pournasr, B.; Khaloughi, K.; ... Generating Desired Cell Types from Abundant and Accessible Cells". Stem Cells. 29 (12): 1933-1941. doi:10.1002/stem.760. PMID ... Nature Cell Biology. 13 (3): 215-222. doi:10.1038/ncb2164. PMID 21278734. S2CID 5310172. Kim, J.; Efe, J. A.; Zhu, S.; ... polygonal hyaline chondrogenic cells (Klf4, c-Myc, Sox9) Mouse dermal fibroblasts → cardiomyocytes (Oct4, Sox2, Klf4, JI1 and ...
... pancreatic beta-cell-like' cells. The cells induced a wide, functional and long-lasting transdifferentiation process that ... Generally transdifferentiation that occurs in mouse cells does not translate in effectiveness or speediness in human cells. ... Transdifferentiation requires fewer cell passages and would reduce the chance of mutations. Transdifferentiation can also be ... 1987 reported the first instance (sight) of transdifferentiation where a cell changed from one adult cell type to another. ...
Qin, H.; Zhao, A.; Fu, X. (2017). "Small molecules for reprogramming and transdifferentiation". Cellular and Molecular Life ... The second being a somatic cell, referring to the cells of the human body. Skin cells, fat cells, and liver cells are only a ... "Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer". Cell. 153 (6): 1228-38. doi:10.1016/j.cell.2013.05.006. ... The Scientist 19 June 2007 Human Somatic Cell Nuclear Transfer Using Adult Cells Cell Stem Cell. Retrieved 18 April 2014 Ariana ...
In 1995 he pioneered this technique permitting the transdifferentiation of white blood cells into red blood cell precursors and ... "Historical Origins of Transdifferentiation and Reprogramming". Cell Stem Cell. 9 (6): 504-516. doi:10.1016/j.stem.2011.11.012. ... Baker, Monya (2008-10-23). "Thomas Graf: Cellular identity and transdifferentiation". Nature Reports Stem Cells: 1. doi:10.1038 ... He is a pioneer in cell reprogramming, showing that blood cells can be transdifferentiated by transcription factors. He is also ...
... for transdifferentiation of human skin cells into beating heart cells. With this method, more than 97% of the cells began ... May 2013). "TAP-deficient human iPS cell-derived myeloid cell lines as unlimited cell source for dendritic cell-like antigen- ... June 2014). "Human somatic cell nuclear transfer using adult cells". Cell Stem Cell. 14 (6): 777-80. doi:10.1016/j.stem.2014.03 ... June 2013). "Human embryonic stem cells derived by somatic cell nuclear transfer". Cell. 153 (6): 1228-38. doi:10.1016/j.cell. ...
Two mammalian cell lines are commonly used as models of the proximal tubule: porcine LLC-PK1 cells and marsupial OK cells. Most ... undergoing epithelial mesenchymal trans-differentiation; necrosis or apoptosis.[citation needed] Urinary pole Brush border List ... Cuboidal epithelial cells lining the proximal tubule have extensive lateral interdigitations between neighboring cells, which ... The mitochondria are needed in order to supply the energy for the active transport of sodium ions out of the cells to create a ...
Transdifferentiation experiments were carried out. They tried to change the cell fate without proceeding through a pluripotent ... fibroblast cells to myoblast cells, fibroblast cells to cardiomyocyte cells, fibroblast cells to neurons Cell replacement ... In 2006, he and his team generated induced pluripotent stem cells (iPS cells) from adult mouse fibroblasts. iPS cells closely ... Therefore, non-differentiated egg/early embryo cells can only develop into specialized cells. However, stem cells with limited ...
Epithelial to mesenchymal transdifferentiation (EMT) of an epithelial cell. Perhaps the most studied pathway of myofibroblast ... Partial smooth muscle differentiation of a fibroblastic cell Activation of a stellate cell (e.g. hepatic Ito cells or ... A myofibroblast is a cell phenotype that was first described as being in a state between a fibroblast and a smooth muscle cell ... Pericytes and renal mesangial cells are some examples of modified myofibroblast-like cells. Myofibroblasts may interfere with ...
... cell regeneration through transdifferentiation of pancreatic α‐ to β‐cells". Cell Biology International. International ... Glucagonoma Beta cell Delta cell List of human cell types derived from the germ layers List of distinct cell types in the adult ... Alpha cellscells) are endocrine cells that are found in the Islets of Langerhans in the pancreas. Alpha cells secrete the ... Alpha cells are endocrine cells, meaning they secrete a hormone, in this case glucagon. Alpha cells store this glucagon in ...
Somatic expression of combined transcription factors can directly induce other defined somatic cell fates (transdifferentiation ... Cell potency is a cell's ability to differentiate into other cell types. The more cell types a cell can differentiate into, the ... In cell biology, a unipotent cell is the concept that one stem cell has the capacity to differentiate into only one cell type. ... A close synonym for unipotent cell is precursor cell. Biology portal Induced stem cells Cell totipotency was discovered by ...
SCR/SP11 - are small polymorphic peptides produced by the tapetal cells of anthers and is involved in self-incompatibility of ... PSK has been demonstrated to promote cellular proliferation and transdifferentiation. It has been demonstrated that PSK binds ... These proteins are secreted from cells in the floral abscission zone. Studies suggest that the HAESA membrane-associated LRR- ... February 2005). "Reduction of cell size induced by enod40 in Arabidopsis thaliana". J. Exp. Bot. 56 (412): 507-13. doi:10.1093/ ...
Kaur K, Yang J, Eisenberg CA, Eisenberg LM (October 2014). "5-azacytidine promotes the transdifferentiation of cardiac cells to ... Azacitidine causes anemia (low red blood cell counts), neutropenia (low white blood cell counts), and thrombocytopenia (low ... doi:10.1089/cell.2014.0021. PMID 25090621. Wang X, Zou P, Wu F, Lu L, Jiang S (December 2017). "Development of small-molecule ... has a compromised efficacy as a cardiac differentiation factor because it promotes the transdifferentiation of cardiac cells to ...
"In vitro transdifferentiation of human skin keratinocytes to corneal epithelial cells". celltherapyjournal.org. Retrieved 30 ... Vidya Pradeep completed her PhD in Stem Cell Biology at an eye hospital in Chennai. She works on ocular stem cells, and her ... "Actress Vidya Pradeep gets doctorate in Stem Cell Biology; To head to US for job". The Times of India. Archived from the ... "Thadam Actress Vidya Pradeep Gets Doctorate In Stem Cell Biology, To Head For The US » GossipChimp , Trending K-Drama, TV, ...
... this transdifferentiation can form cells with a neural lineage. Induced somatic stem cells Mahla RS (2016). "Stem Cells ... these cells have the same ability as embryonic stem cells to develop into many different cell types. Olfactory stem cells hold ... such as mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, etc.). A great deal of adult stem cell ... Pluripotent stem cells, i.e. cells that can give rise to any fetal or adult cell type, can be found in several tissues, ...
Reprogrammed adult supporting cells show transdifferentiation into hair cell-like cells upon exposure to hair cell induction ... Claudius cells, inner phalangeal cells, and inner and outer pillar cells. Hensen's cells, Deiter's cells, and outer hair cells ... Direct transdifferentiation is when neighboring supporting cells convert into hair cells without cell division. Inner ear ... Supporting cells are also responsible for removing damaged hair cells from the inner ear. Hair cells and most supporting cells ...
The coelomic fluid contains the coelomocytes, or immune cells. There are several types of immune cells, which vary among ... Direct transdifferentiation of one type of tissue to another during tissue replacement is also observed. Echinoderms become ... vibratile cells (for coelomic fluid movement and clotting), and crystal cells (which may serve for osmoregulation in sea ... "Regulation of dynamic pigment cell states at single-cell resolution". eLife. 9. doi:10.7554/elife.60388. PMC 7455242. PMID ...
Influence of embryonic stage on the transdifferentiation of chick neural retina cells in culture. J Embryol Exp Morphol. 1978 ... The expression of chick alpha A2-crystallin RNA during lens development and transdifferentiation. Biol Cell. 1985;54(2):101-8. ... The influence of the genotype on the process of ageing of chick lens cells in vitro. Exp Cell Res. 1988 Feb;174(2):330-43. ... Relationship between crystallin mRNA expression in retina cells and their capacity to re-differentiate into lens cells. Nature ...
May 2018). "Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged ... Molecular and Cell Biology of Lipids. 1821 (4): 694-705. doi:10.1016/j.bbalip.2012.01.009. PMID 22285325. Oka S, Toshida T, ...
"The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells". ... Fatty acids in the beta cells activate FOXO1, resulting in apoptosis of the beta cells. FOXO1 activation plays a role in cell ... It suppresses survival of tumor cells by inducing apoptosis in prostate cancer cells and glioma cells by upregulating the ... In pancreatic beta cells FOXO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. When the level of blood ...
May 2018). "Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged ... to cause host cell (macrophage) apoptosis through cytochrome C release. LPCs are present as minor phospholipids in the cell ... Invading T cells are also thought to mediate this process. Bacteria such as Legionella pneumophila utilize phospholipase A2 end ... LPC also acts as a find-me signal, released by apoptotic cells to recruit phagocytes, which then phagocytose the apoptotic ...
Diabetes, insulin, trans-differentiation, stem cells, and regenerative medicine are all search phrases. GRCh38: Ensembl release ... including pancreatic exocrine cells, hepatocytes, and pluripotent stem cells, in addition to their natural roles in beta cell ... PDX1, NEUROG3, and/or MAFA have been effectively used to convert numerous cell types into insulin-producing cells in vitro and ... PDX1 is required for the formation of exocrine and endocrine cells in the pancreas, especially beta cells. PDX1 also attaches ...
However, there is also a second definition of transdifferentiation, in which cells can be directly induced into a new cell type ... differentiated cell. Re-entry into the cell cycle allows the cell to go through mitosis, dividing to make more cells that would ... Articles with short description, Short description matches Wikidata, Cells, Cell biology, Stem cells). ... as seen by an increase in cell cycle re-entry and loss of cellular adhesion. Cell plasticity [9] is the idea that cells can ...
His lab also discovered and developed methods for the purification and culturing of retinal ganglion cells and the glial cells ... "Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth". ... doi:10.1038/d41586-017-08964-1. Raff, Martin C. (October 1993). "Programmed Cell Death and the Control of Cell Survival: ... understand the cell-to-cell interactions in the developmental regulation of nodes of Ranvier and myelin sheaths; 2) determine ...
This inhibitor specifically targets Rho GTPases to prevent cell growth related to cancer. When tested on breast cancer cells, ... January 2001). "Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA- ... We have used a stable retroviral RNA interference approach to generate invasive breast carcinoma cells (SUM-159 cells) that ... Chronic Myeloid Leukemia (CML), a stem cell disorder that prevents myeloid cells from functioning correctly, has been linked to ...
Transdifferentiation of MSCs into excitable neuron-like cells has been shown to be possible in vitro and these cells respond to ... The terminal differentiation of some somatic stem cells has recently been called into question after studies of transplanted ... However, it is unlikely that this degree of transdifferentiation occurs in vivo and that ... haematopoietic stem cells showed the development of myoblasts, endothelium, epithelium and neuroectodermal cells, suggesting ...
"A role for Id in the regulation of TGF-beta-induced epithelial-mesenchymal transdifferentiation". Cell Death and ... An increase in ID expression is seen in embryonic and adult stem cells. ID proteins also promote cell cycle progression, ... When ID proteins are overexpressed, cell proliferation is enhanced and cells become insensitive to growth factor depletion. ... When ID1 was knocked out, a defect in T-cell migration was seen. A knockout of ID2 showed that 25% of mice died perinatally, ...
"Cochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling". ... The supporting cells including Hensen's cells and Deiter's cells which surround the sensory cells in the organ of Corti are ... and reproduce both new hair cells and supporting cells into the cell cycle, one of the reasons is because the supporting cells ... Hensen's cells are a layer of tall cells arranged in the organ of Corti in the cochlea, which are part of the supporting cells ...
The ability of transdifferentiation, a non-stem cell which can morph into a different type of cell, in these cells is pivotal ... Medusae transforming into polyps and cell transdifferentiation in Turritopsis nutricula (Cnidaria, Hydrozoa)". The Biological ... It is unknown whether or not stem cells play a role in this process. Due to this regular transformation by T. nutricula, it is ... This regression from medusa to polyp has only been observed with the presence of differentiated cells from the outer umbrella ...
B cell-derived tumors arose at high incidence and displayed Ig gene rearrangement with downregulated expression of B cell- ... Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice. ... Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice. ... these tumors exhibited characteristics of transdifferentiation and acquired expression of histiocytic/dendritic cell markers. ...
Cell migration assay. Cells were seeded in six-well plates and allowed to grow to confluence. The cells were starved overnight ... Cells were seeded (5000 cells/well) in 96-well culture plates. After serum starvation overnight, the cells were treated with ... such as cell proliferation, migration, and transdifferentiation in fibroblasts and other cell types [15,28-30]. It is worth ... Cell Signaling Technology), ERK1/2 (#4695, 1:1,000, Cell Signaling Technology), phospho-ERK1/2 (#4370, 1:1,000, Cell Signaling ...
... granulosa and thecal cells → functional Sertoli-like and Leydig-like cells (-Foxl1) Transdifferentiation Induced stem cells ... A list of examples of in vivo transdifferentiation through transfection: mouse hepatocytes → B cells (Pdx1) exocrine cells → B ... Generating Desired Cell Types from Abundant and Accessible Cells". Stem Cells. 29 (12): 1933-1941. doi:10.1002/stem.760. PMID ... Cell. 139 (6): 1130-1142. doi:10.1016/j.cell.2009.11.021. PMID 20005806. (Histology, Induced stem cells). ...
These data show that human hepatocytes can be induced to undergo partial pancreatic transdifferentiation in vivo, indicating ... animal models of diabetes resulted in the reversal of diabetes and partial pancreatic transdifferentiation of liver cells. The ... Partial pancreatic transdifferentiation of primary human hepatocytes in the livers of a humanised mouse model J Gene Med. 2018 ... Conclusions: These data show that human hepatocytes can be induced to undergo partial pancreatic transdifferentiation in vivo, ...
Pharmacologic inhibition of p38 abrogates TGF-beta-induced myofibroblast transdifferentiation, reduces extracellular matrix ... Cell proliferation was measured with an MTT assay. Specific pharmacologic kinase inhibitors were used to characterize the ... p38 inhibitors prevent TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts Invest Ophthalmol Vis Sci ... Purpose: The role of mitogen-activated protein kinase (MAPK) pathways in TGF-beta-induced myofibroblast transdifferentiation of ...
A recent study demonstrated the transdifferentiation of T helper type 2 cell (Th2)-like regulatory T cells (Tregs) in SSc ... Th2- and Th17-like cell proportions in skin-homing Tregs were increased in bleomycin-treated Fli1 +/− mice compared with ... Under the same coculture condition, an increased tendency of IL-17A-producing cell proportion, which was possibly mediated by ... Cytokine expression was assessed in Tregs by flow cytometry and in skin samples and cultivated cells by immunostaining, ...
SARS-CoV-2 Infection Induces Beta-Cell Transdifferentiation. Friday, June 3 at 11:30 a.m. CT. La Nouvelle Orleans Ballroom C. ... Trans-ISRIB reverses SARS-CoV-2 infection-induced beta cell transdifferentiation.. *Proinflammatory macrophages are activated ... Presenter Profiles: SARS-CoV-2 Infection Induces Beta-Cell Transdifferentiation. By Shuibing Chen, PhD ... When I joined Melton lab back in 2007, Doug focused on developing strategies to convert stem cells to pancreatic beta cells for ...
Engraftment and transdifferentiation into lung structural cells. Engraftment and transdifferentiation of MSCs in epithelial ... Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis. Stem Cells Int 2016;2016:1-11 ... Functional heterogeneity of mesenchymal stem cells: implications for cell therapy. J Cell Biochem 2012;113:2806-12.doi:10.1002/ ... These effects are exerted through direct cell-to-cell contact (eg, via programmed death-1 for MSC and T-cell interactions), ...
Additionally, sub-acute Ang conditioning increased cell size and promoted trans-differentiation into myofibroblasts. To provide ... Additionally, sub-acute Ang conditioning increased cell size and promoted trans-differentiation into myofibroblasts. To provide ... Angiotensin-II drives human satellite cells toward hypertrophy and myofibroblast trans-differentiation by two independent ... Angiotensin-II drives human satellite cells toward hypertrophy and myofibroblast trans-differentiation by two independent ...
The SNAG Domain of Insm1 Regulates Pancreatic Endocrine Cell Differentiation and Represses Beta- to Delta-Cell ... We further identified that the increased delta-cell number is due to beta- to delta-cell transdifferentiation. Mechanistically ... Pancreatic Islet Cell DifferentiationDelta CellsPancreatic IsletsBeta Cell BiologyBeta Cell Transcriptional Regulation ... The SNAG Domain of Insm1 Regulates Pancreatic Endocrine Cell Differentiation and Represses Beta- to Delta-Cell ...
Myeloid gene, article, binding site, cell function, cell lineage, cell transdifferentiation, controlled study, down regulation, ... HDAC7 Is a Repressor of Myeloid Genes Whose Downregulation Is Required for Transdifferentiation of Pre-B Cells into Macrophages ... HDAC7 Is a Repressor of Myeloid Genes Whose Downregulation Is Required for Transdifferentiation of Pre-B Cells into Macrophages ... Thus, in B cells HDAC7 is a transcriptional repressor of undesirable genes. Our findings uncover a novel role for HDAC7 in ...
SARS-CoV-2 infection induces beta cell transdifferentiation. Cell Metab. 33, 1577-1591 (2021). ... A glass microfluidic chip for continuous blood cell sorting by a magnetic gradient without labeling. Anal. Bioanal. Chem. 392, ... SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nat. Metab. 3, 149-165 (2021). ... Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University of Advanced Study, Kyoto University, 606-8501, Kyoto ...
... a chronic illness characterized by the bodys inability to produce insulin due to the autoimmune destruction of the beta cells ... SARS-CoV-2 infection induces beta cell transdifferentiation. Cell Metab. 2021 May 19. [QxMD MEDLINE Link]. [Full Text]. ... SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment. Cell Metab. 2021 May 18. [QxMD MEDLINE Link]. [Full ... with these cells possibly undergoing transdifferentiation. [43] A study by Wu et al also indicated that infected beta cells ...
potent stromal cells. The state of transdifferentiation and modes of. tissue repair: current views. Stem Cells. 2007;25(11): ... stem cells derived from various mesenchymal tissues: superiority of. synovium as a cell source. Arthritis Rheum. 2005;52(8): ... Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. ... and stem or stromal cell therapy, including mesenchymal stem cell allografts, and adipose tissue-derived stem cells, and ...
Osteoblastic cells: differentiation and trans-differentiation. Arch. Biochem. Biophys. 473:183-187.). ... Osteoblastic cells: differentiation and trans-differentiation. Arch. Biochem. Biophys. 473:183-187. ... Mesenchymal stem cells: sources, phenotype, and differentiation potential. Cell Biol. 33:2-18.). Essas populações são também ... Bone marrow-and subcutaneous adipose tissue-derived mesenchymal stem cells. Cell Cycle 11:377-383.), com o local de colheita ( ...
They are secreted by a range of cell types and via blood reaching other cells whose functioning they can modify because they ... focusing on cell-cell communication in physiology and pathology. ... They are involved in cell differentiation, tissue homeostasis, ... are membranous particles released by cells into the extracellular space. ... Directed glial differentiation and transdifferentiation for neural tissue regeneration. Exp. Neurol. 2018. [Google Scholar] [ ...
Ribosome incorporation into somatic cells promotes transdifferentiation towards multipotency. Scientific Reports, 8(1):1634, ... Methylome, transcriptome, and PPARγ cistrome analyses reveal two epigenetic transitions in fat cells. Epigenetics,9(9):1195- ... Adipose-derived mesenchymal stem cells differentiate into heterogeneous cancer-associated fibroblasts in a stroma-rich ... Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells. ...
Plants construct two types of cell walls, primary cell walls (PCWs) and secondary cell walls (SCWs), which differ in ... Cellulose synthase complexes display distinct dynamic behaviors during xylem transdifferentiation journal, June 2018 * Watanabe ... The cell biology of secondary cell wall biosynthesis journal, February 2018 * Meents, Miranda J.; Watanabe, Yoichiro; Samuels, ... Building a plant cell wall at a glance journal, January 2018 * Lampugnani, Edwin R.; Khan, Ghazanfar Abbas; Somssich, Marc ...
It does this through the cell development process of transdifferentiation. Scientists believe the cycle can repeat indefinitely ... You could do what they tried to do on a cell phone." At a congressional hearing last April, Representative Alan Mollohan, a ...
SARS-CoV-2 infection induces beta cell transdifferentiation. Cell Metab. 2021 08 03; 33(8):1577-1591.e7. ... Merkel Cell Carcinoma Sensitivity to EZH2 Inhibition Is Mediated by SIX1 Derepression. J Invest Dermatol. 2022 10; 142(10):2783 ... Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome. Nat Commun. 2017 01 09; 8:14060. ... Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers. Blood. ...
Neuroendocrine-like prostate cancer cells: neuroendocrine transdifferentiation of prostate adenocarcinoma cells. Endocr Relat ... On the basis of the high and specific target expression level of most prostate cancer cells, PSMA-ligand PET/CT detects more ...
Ectopic expression of H. pylori virulence factor CagA leads to trans-differentiation of primary gastric epithelial cells. M. ... Allergic potential of bacteria isolated from pollen of the common hazel (Corylus avellana L.) tested on lung epithelial cells ... Effects of the human milk oligosaccarides 2´-fucosyllactose on ephithelial cell gene expression and microbiota. L. Bode, S. ...
Transdifferentiation is defined as the conversion of one differentiated cell type to another. It belongs to a wider class of ... Explore Stem Cells Find out about stem cells and stem cell research ... The Tosh group has developed a number of models for the transdifferentiation of pancreas to liver and the reverse. They use ... their studies of transdifferentiation and metaplasia to help:. *Understand the normal developmental biology of the cells that ...
highlighted by preview "mTOR Is Key to T Cell Transdifferentiation" in Cell Metab). ... Cell Res 29:391-405, 2019.. Saravia J, Chapman NM, Chi H. Helper T cell differentiation. Cell Mol Immunol 16:634-643, 2019. ( ... Genetic dissection of dendritic cell homeostasis and function: lessons from cell type-specific gene ablation. Cell Mol Life Sci ... the molecular pathways intrinsic to T cells, and the pathways that act in dendritic cells to cross-regulate T cell responses. ...
Piraino S, et al: Reversing the life cycle: Medusae transforming into polyps and cell transdifferentiation in Turritopsis ... First, as stem cells suffer from telomere attrition, they slow down in replacing the skin and blood and immune cells that are ... The bodys cells are mutating as the number of different immune memory cells is multiplying. Chance coincidences result in the ... Campisi J: Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005;120:513-522. ...
Researchers turn rat stem cells into mouse marrow cells. ScienceBlog.com Researchers in North Carolina have successfully ... The accomplishment, known as hematopoietic transdifferentiation, may prove useful for tapping the potential for tissue repair ... Specifically, the researchers converted adult liver stem cells cloned from a male rat into functional adult bone marrow cells ... Now, for the first time, scientists have identified a specific molecular pathway within cells that becomes mutated by ...
Several types of stem cells have been used to study liver diseases; mesenchymal stem cells are most commonly used because they ... In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. ... The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in ... to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize ...
A novel LSD1 inhibitor T-3775440 induces transdifferentiation in AML cell lines. ... Withaferin A (WA) causes cell death in prostate cells.. GSE55843. Loss and dysfunction of Vdelta2+ gammadelta-low T cells is ... Comparison of gene expression profiles of colorectal adenocarcinoma HT-29 cells and oral squamous cell carcinoma Ca9-22 cells ... HCoV-229E infection in A549 cells: gene regulation in cells adjacent and distant to infected cells. ...
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel ... This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. ... In addition, the number and the migratory activity of these cells are inversely correlated with risk factors such as ... Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described ...
... with increased cancer stem cell features. This transformation of a cell type into another one is called transdifferentiation. ... One of the first steps is understanding from which cell type the cancer originates: the cell-of-origin. ... Uncovering the cell-of-origin in fibrolamellar carcinoma. To be able to develop new therapies, it is also essential to ... CAR T-Cell therapy outcomes similar across different socioeconomic levels among paediatric patients with ALL 10 Nov 2022 ...
  • Friend leukemia virus integration 1 (Fli1) deficiency, a predisposing factor of systemic sclerosis (SSc), induces SSc-like phenotypes in various cell types. (biomedcentral.com)
  • Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells. (harvard.edu)
  • MYOD1, a master gene regulator, induces transdifferentiation of a variety of cell types into skeletal muscle, although inefficiently in human cells. (duke.edu)
  • Damage to ECs is catastrophic and induces endothelial cell dysfunction. (koreamed.org)
  • Up-regulation of autophagy induces endothelial cell regeneration/differentiation and improves the function of impaired ones. (koreamed.org)
  • The role of mitogen-activated protein kinase (MAPK) pathways in TGF-beta-induced myofibroblast transdifferentiation of human tenon fibroblasts (HTFs) was investigated to identify potential pharmacologic targets for the inhibition of scarring after glaucoma surgery. (nih.gov)
  • TGF-beta-induced mRNA expression of collagen Ialpha1, fibronectin, and the myofibroblast transdifferentiation marker alpha smooth muscle actin (alpha-SMA) was analyzed by real-time RT-PCR. (nih.gov)
  • Pharmacologic inhibition of p38 abrogates TGF-beta-induced myofibroblast transdifferentiation, reduces extracellular matrix protein expression and HTF proliferation, and may therefore serve to inhibit scarring after glaucoma surgery. (nih.gov)
  • Mutual paracrine effects of oral squamous cell carcinoma cells and normal oral fibroblasts: induction of fibroblast to myofibroblast transdifferentiation and modulation of tumor cell proliferation. (bvsalud.org)
  • Primary cultured HTFs were incubated with transforming growth factor β1 (TGF-β1) alone or combined with nintedanib, and cell proliferation and migration were measured by cell counting kit-8 (CCK8) and the scratch wound assay, respectively. (molvis.org)
  • Cell proliferation was measured with an MTT assay. (nih.gov)
  • Following early observations that MSCs inhibit T-cell proliferation, 9 MSCs were found to interact with the majority of innate and adaptive immune cells. (bmj.com)
  • Mechanistically, manipulation of individual signalling pathways modulated the transdifferentiation process via myoblast proliferation, lowering the transdifferentiation threshold and inducing cell fusion. (duke.edu)
  • WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
  • Here, we have revealed the role of viral FLICE-inhibitory protein (vFLIP) in the initiation of PEL and MCD by specifically expressing vFLIP at different stages of B cell differentiation in vivo. (jci.org)
  • Additionally, sub-acute Ang conditioning increased cell size and promoted trans-differentiation into myofibroblasts. (unifi.it)
  • The Insulinoma-associated protein 1 ( Insm1 ), which encodes a protein containing one SNAG domain and five zinc fingers, plays essential roles in pancreatic endocrine cell differentiation and in mature beta-cell function. (figshare.com)
  • In the present study, we compared the differentiation of pancreatic endocrine cells between Insm1 null and Insm1 SNAG domain mutants (Insm1delSNAG) to explore the specific function of the SNAG domain of Insm1. (figshare.com)
  • Our study has identified a novel function of the SNAG domain of Insm1 in the regulation of pancreatic endocrine cells differentiation, particularly in the repression of beta- to delta-cell transdifferentiation. (figshare.com)
  • B lymphopoiesis is the result of several cell-commitment, lineage-choice, and differentiation processes. (eur.nl)
  • To date, the central role of specific transcription factors in positively regulating these distinct differentiation processes to acquire a B cell-specific genetic program is well established. (eur.nl)
  • The cells were phenotypically categorized according to the expression of CD29, CD90, CD34 and CD45, and submitted to adipogenic and chondrogenic differentiation for 21 days and osteogenic differentiation for 7, 14 and 21 days. (scielo.br)
  • On days 7, 14 and 21 of osteogenic differentiation, the cultures were submitted to evaluations of MTT conversion in formazan, of alkaline phosphatase activity (AP), of collagen and mineralized matrix synthesis, evaluation of the number of cells per field and there was quantification of the gene transcripts for osterix, bone sialoprotein (BSP), osteonectin (ON) and osteocalcin (OC). (scielo.br)
  • The number of cells per field, the AP activity, the collagen and mineralized matrix synthesis were higher in AT-MSC en differentiation, in relation to BM-MSC under the same conditions in all evaluated times. (scielo.br)
  • Our laboratory has a long-standing interest in immune signaling and cell metabolism underlying the differentiation and function of T cells, a central cell type in adaptive immunity and cancer immunotherapy. (stjude.org)
  • For dendritic cell-mediated extrinsic control of T cell differentiation, we focus on metabolic and inflammatory pathways (see Du Nature 2018). (stjude.org)
  • Their physiological accuracy, however, is hampered by the lack of an easily accessible human cell source that is readily expandable and capable of efficient differentiation. (duke.edu)
  • In cochlear hair cells, it is critical for elongation and differentiation of the stereocilia [ 20 ]. (hindawi.com)
  • Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
  • A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
  • Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)
  • Differentiation of islet cells from mesenchymal stem cells (MSCs) is a potential solution to the challenge of insufficient donor sources. (bvsalud.org)
  • The accomplishment, known as hematopoietic transdifferentiation, may prove useful for tapping the potential for tissue repair using human adult stem cells. (scienceblog.com)
  • We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)
  • We report that the histone deacetylase HDAC7 was highly expressed in pre-B cells but dramatically down-regulated during cellular lineage conversion to macrophages. (eur.nl)
  • Available at: h ttps://pubmed.ncbi.nlm.nih.gov/30753992-exosomal-transmission-of-microrna-from-hcv-replicating-cells-stimulates-transdifferentiation-in-hepatic-stellate-cells/ [Accessed 25 Feb. 2020]. (bioscience.co.uk)
  • In the liver, cell types such as hepatocytes, immune cells, and hepatic stellate cells (HSC) interact with each other. (frontiersin.org)
  • A recent study demonstrated the transdifferentiation of T helper type 2 cell (Th2)-like regulatory T cells (Tregs) in SSc lesional skin through interleukin (IL)-33 produced by fibroblasts. (biomedcentral.com)
  • Importantly, the IL-4-producing cell proportion was significantly higher in wild-type Tregs cocultured with Fli1 +/− fibroblasts than in those cocultured with wild-type fibroblasts, which were canceled by neutralizing anti-IL-33 antibody. (biomedcentral.com)
  • Fli1 haploinsufficiency increases the proportions of Th2- and Th17-like Tregs in bleomycin-induced profibrotic skin conditions, in which IL-33-producing dermal fibroblasts contribute to Th2-like Treg transdifferentiation, suggesting a critical role of Fli1 deficiency in the interaction of dermal fibroblasts with immune cells in pathological skin fibrosis. (biomedcentral.com)
  • However, a recent study has demonstrated that activated fibroblasts regulate tissue-localized transdifferentiation of regulatory T cells (Tregs) into T helper type 2 cell (Th2)-like cells through IL-33 in SSc lesional skin [ 2 ], suggesting that activated dermal fibroblasts amplify an aberrant immune response characteristic of SSc. (biomedcentral.com)
  • Fli1 expression is suppressed in dermal fibroblasts, endothelial cells, and perivascular inflammatory cells in involved and noninvolved skin of patients with SSc [ 11 ]. (biomedcentral.com)
  • Adipose-derived mesenchymal stem cells differentiate into heterogeneous cancer-associated fibroblasts in a stroma-rich xenograft model. (go.jp)
  • By activating this pathway, some of the cancer cells transformed into fibroblasts, which are essential in making connective tissue in our bodies. (a-star.edu.sg)
  • Scholars@Duke publication: Efficient transdifferentiation of human dermal fibroblasts into skeletal muscle. (duke.edu)
  • Here we used MYOD1 to establish its capacity to induce skeletal muscle transdifferentiation of human dermal fibroblasts under baseline conditions. (duke.edu)
  • The role of exosomes collected by ultracentrifugation were also analyzed as mediators of p53 expression in cancer cells and APJ expression in fibroblasts. (spandidos-publications.com)
  • APJ expression in fibroblasts co‑cultured with p53‑suppressed colon cancer cells (HCT116 sh p53 cells) was significantly lower than in control colon cancer cells (HCT116 sh control cells). (spandidos-publications.com)
  • In addition, xenografts of HCT116 cells with APJ‑suppressed fibroblasts showed accelerated tumor growth. (spandidos-publications.com)
  • MicroRNA 5703 enriched in exosomes derived from HCT116 sh p53 cells inhibited APJ expression, and inhibition of miR‑5703 diminished APJ suppression in fibroblasts caused by cancer cells. (spandidos-publications.com)
  • APJ suppression from a specific microRNA in cancer cell‑derived exosomes induced CAF‑like properties in fibroblasts. (spandidos-publications.com)
  • The tumor microenvironment consists of various cell types and fibroblasts in the tumor tissue, called cancer-associated fibroblasts (CAFs), which play pivotal role in tumor progression ( 7 , 8 ). (spandidos-publications.com)
  • 2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)
  • B cell-derived tumors arose at high incidence and displayed Ig gene rearrangement with downregulated expression of B cell-associated antigens, which are features of PEL. (jci.org)
  • Mutation in the SNAG domain of Insm1 results in impaired recruitment of Lsd1 and increased H3K4me1/2 levels at H hex loci that are bound by Insm1, thereby promoting the transcriptional activity of the delta-cell-specific gene Hhex . (figshare.com)
  • Identification of PARD3 signature on PARD3 deficient H157 cell line, reconstituting the expression of PARD3 gene, with a wt and a mutant form. (nih.gov)
  • Understanding the importance of specific gene faults in the initiation of FLC and the original cell could be crucial to understand how the tumour could behave later on. (ecancer.org)
  • The goal is to understand the role of these defined factors in modulating chromatin structure and gene expression during this dynamic process of transdifferentiation. (helsinki.fi)
  • The mutational inactivation of the TP53 gene in tumor cells has been reported to affect not only tumor cells but also the surrounding cells in the tumor microenvironment and to promote tumor-stromal activation and subsequent tumor growth ( 11 , 12 ). (spandidos-publications.com)
  • This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. (cancerindex.org)
  • Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
  • In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
  • Within the underlying theme of our research, we explore T cell responses from two complementary angles: the molecular pathways intrinsic to T cells, and the pathways that act in dendritic cells to cross-regulate T cell responses. (stjude.org)
  • Overall, we used transdifferentiation to achieve the robust derivation of human skeletal myotubes and have described the signalling pathways and mechanisms regulating this process. (duke.edu)
  • The pathogenesis is multifactorial and involves dysregulation in the signaling pathways, membrane lipids ratio disturbance, cell-cell adhesion disturbance, unfolded protein response, lysosomal and mitochondrial stress, autophagy dysregulation, and oxidative stress. (koreamed.org)
  • In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)
  • 1 Unique MSC-specific markers have not yet been identified, and MSCs constitute a heterogeneous cell population, including both multipotent (stem) cells and progenitor cells and might even contain pluripotent cell fractions. (bmj.com)
  • Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
  • Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
  • To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)
  • The present study investigated whether streptozotocin-diabetes could be reversed in FRG mice in which chimeric mouse-human livers can readily be established and, in addition, whether pancreatic transdifferentiation occurred in the engrafted human hepatocytes. (nih.gov)
  • Quantitative RT-PCR showed expression of human and mouse endocrine hormones and β-cell transcription factors, indicating partial pancreatic transdifferentiation of mouse and human hepatocytes. (nih.gov)
  • These data show that human hepatocytes can be induced to undergo partial pancreatic transdifferentiation in vivo, indicating that the technology holds promise for the treatment of type 1 diabetes. (nih.gov)
  • After I became independent, I continued working in this field and used stem cell models to study the impact of genetic and environmental factors on diabetes progression. (adameetingnews.org)
  • It belongs to a wider class of cell type conversions known as metaplasias that include conversions between stem cell types. (eurostemcell.org)
  • The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
  • Professor Ma heads the Blood, Stem Cell and Cancer Research Programme at St Vincent's Centre for Applied Medical Research, Sydney. (edu.au)
  • His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)
  • Stem Cell Research Advances , edn. (edu.au)
  • Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)
  • The nature of the stem cell substates and their relationship to commitment to differ- entiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors. (lu.se)
  • Bhowmick NA, Ghiassi M, Bakin A. Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. (bdbiosciences.com)
  • These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
  • Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
  • Endothelial cells (EC) are the anatomical boundaries between the intravascular and extravascular space. (koreamed.org)
  • Fig. 2 Schematic presentation of the role of autophagy in endothelial cells. (koreamed.org)
  • Tree of life: endothelial cell in norm and disease, the good guy is a partner in crime! (koreamed.org)
  • Central role of metabolism in endothelial cell function and vascular disease. (koreamed.org)
  • EndoDB: a database of endothelial cell transcriptomics data. (koreamed.org)
  • Merkel Cell Carcinoma Sensitivity to EZH2 Inhibition Is Mediated by SIX1 Derepression. (harvard.edu)
  • We found significant transdifferentiation improvement via transforming growth factor-β/activin signalling inhibition, canonical WNT signalling activation, receptor tyrosine kinase binding and collagen type I utilization. (duke.edu)
  • We have previously shown that the introduction of furin-cleavable human insulin (INS-FUR) to the livers in several animal models of diabetes resulted in the reversal of diabetes and partial pancreatic transdifferentiation of liver cells. (nih.gov)
  • Yet, this single mutation caused a rather mild effect on the overall cellular and molecular behaviour of the liver cells. (ecancer.org)
  • Our findings uncover a novel role for HDAC7 in maintaining the identity of a particular cell type by silencing lineage-inappropriate genes. (eur.nl)
  • In Drosophila with depleted RACK1 in all muscle cells or, specifically, in SC lineage resulted in a delayed recovery of skeletal muscle after physical damage as well as the low presence of active SC in the wound area. (sdbonline.org)
  • This requirement strongly limits the number of solutions or entiation and lineage-specification, programmed cell death, and ``states'' for the system. (lu.se)
  • A reverse developmental process in which terminally differentiated cells with specialized functions revert back to a less differentiated stage within their own CELL LINEAGE. (bvsalud.org)
  • Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome. (harvard.edu)
  • Interestingly, these tumors exhibited characteristics of transdifferentiation and acquired expression of histiocytic/dendritic cell markers. (jci.org)
  • This transformation, referred to as transdifferentiation, reduces the cancer cells' ability to form tumors and grow aggressively. (a-star.edu.sg)
  • When I joined Melton lab back in 2007, Doug focused on developing strategies to convert stem cells to pancreatic beta cells for replacement therapy for diabetic patients. (adameetingnews.org)
  • Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease? (bmj.com)
  • In this review, we discuss the rationale for MSC-based cell therapy in COPD, the main findings from in vitro and in vivo preclinical COPD model studies, clinical trials in patients with COPD and directions for further research. (bmj.com)
  • This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
  • Cell invasion is a crucial step of tumor metastasis , finding new regulators of which offers potential drug targets for cancer therapy. (sdbonline.org)
  • BACKGROUND: Islet cell transplantation is an emerging therapy in the treatment of diabetes mellitus. (bvsalud.org)
  • In vitro cell culture and animal studies have demonstrated that mesenchymal stromal cells (MSCs) have the capacity to modify immune responses and to enhance tissue repair. (bmj.com)
  • Mesenchymal stromal cells (MSCs) are cells of non-haematopoietic origin, with the capacity to differentiate into multiple lineages of the mesenchyme, that is, chondrocytes, osteoblasts and adipocytes. (bmj.com)
  • 2 MSCs were first described in the bone marrow where they constitute a small fraction of cells (0.001%-0.01%) that closely interact with haematopoietic cells to support haematopoiesis and skeletal homeostasis. (bmj.com)
  • Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)
  • MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
  • This study investigated whether human umbilical cord-derived MSCs could effectively differentiate into insulin-producing cells (IPCs) and evaluated the therapeutic efficacy of IPCs in treating diabetes. (bvsalud.org)
  • These results define immunological functions for vFLIP in vivo and reveal what we believe to be a novel viral-mediated tumorigenic mechanism involving B cell reprogramming. (jci.org)
  • Type 1 diabetes is a chronic illness characterized by the body's inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. (medscape.com)
  • The Tosh group has developed a number of models for the transdifferentiation of pancreas to liver and the reverse. (eurostemcell.org)
  • SARS-CoV-2-induced beta cell transdifferentiation is mediated by eIF2 pathway. (adameetingnews.org)
  • Now, for the first time, scientists have identified a specific molecular pathway within cells that becomes mutated by ultraviolet light exposure, thereby speeding up melanoma development. (scienceblog.com)
  • dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)
  • Firstly, loss of dGLYAT suppressed scrib depletion- or Egr overexpression-induced JNK pathway activation and invasive cell migration. (sdbonline.org)
  • Autophagy is a remarkable patho (physiological) process in the cell homeostasis regulation including EC. (koreamed.org)
  • Here we addressed the molecular mechanism behind repression of non-lymphoid genes in B cells. (eur.nl)
  • To gain insight into the molecular mechanisms mediating HDAC7 repression in pre-B cells, we undertook co-immunoprecipitation and chromatin immunoprecipitation experimental approaches. (eur.nl)
  • Similarly, destruction of neonatally abundant pluripotent stem cells would likely have a more pervasive outcome than destruction of The value of incorporating immunologic appeared more severe and/or persistent when single lineages or differentiated cells that pre- data for the toxicologic assessment of drugs, the exposure occurred perinatally when com- dominate in adults. (cdc.gov)
  • The interaction between the GM and intrahepatic immune microenvironment is regulated and stabilized by a complex network of factors including IAg, immune cells, and cytokines. (frontiersin.org)
  • 2008) Tumour suppressor menin is essential for development of the pancreatic endocrine cells J Endocrinol. (who.int)
  • Help identify transcription factors that could be used to reprogram stem cells for therapeutic transplantation. (eurostemcell.org)
  • My area of expertise is in transcription factor biology using several genome-wide functional genomics methods (ChIP-seq/nexus, bulk/single-cell RNA-seq), chromatin conformation (ATAC-seq, DHS-seq), chromatin architecture methods (in situ HiC, ChIA-PET), cell fate conversion using transcription factors (transdifferention) and high-throughput enhancer assays (MPRAs such as STARR-seq). (helsinki.fi)
  • In particular, I use defined transcription factors for converting one cell type to another by a method known as transdifferentiation. (helsinki.fi)
  • This study investigated the link between GM and the intrahepatic T cell receptor (TCR) immune repertoire (IR), and whether GM modulates the intrahepatic immune microenvironment via TCR IR during liver fibrosis. (frontiersin.org)
  • Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
  • RESULTS: After about 3 weeks of in vitro induction, IPCs formed microspheres of 100-200 µm, with >95% viable cells that were dithizone stain positive. (bvsalud.org)
  • Skeletal muscle regeneration is ensured by satellite cells (SC), which upon activation undergo self-renewal and myogenesis. (unifi.it)
  • Skeletal muscle growth and regeneration involves the activity of resident adult stem cells, namely satellite cells (SC). (sdbonline.org)
  • Human mini-livers that present signs of both ductal cells (red) and cancer stem cells (green). (medicalxpress.com)
  • HN - 2008 BX - Von Ebner's Glands MH - Cumulus Cells UI - D054885 MN - A05.360.319.114.630.535.200.500 MN - A06.407.312.497.535.300.500 MN - A11.436.300.500 MS - The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. (bvsalud.org)
  • HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
  • The aim of this study was to compare the osteogenic potential of mesenchymal stem cells obtained from bone marrow (BM-MSC) with those extracted from adipose tissue (AT-MSC) of adult dogs. (scielo.br)
  • Specifically, the researchers converted adult liver stem cells cloned from a male rat into functional adult bone marrow cells in female mice. (scienceblog.com)
  • Th2- and Th17-like cell proportions in skin-homing Tregs were increased in bleomycin-treated Fli1 +/− mice compared with bleomycin-treated wild-type mice, whereas Th1-, Th2-, and Th17-like cell proportions in splenic Tregs were comparable. (biomedcentral.com)
  • We show that the delta-cell number is increased in Insm1delSNAG but not in Insm1 null mutants as compared to the control mice. (figshare.com)
  • Understand the normal developmental biology of the cells that interconvert. (eurostemcell.org)
  • Recently, we apply systems biology approaches, such as proteomics, metabolomics, single cell RNA-sequencing (scRNA-seq), CRISPR screening and integrative network analysis, to reconstruct metabolic signaling circuits and identify new therapeutic targets. (stjude.org)
  • International Journal of Biochemistry and Cell Biology. (edu.au)
  • This study aims to understand the function and mechanism of Drosophila Glycine N-acyltransferase (GLYAT) in cell invasion. (sdbonline.org)
  • The levels of catalase (CAT) and glutathione (GSH) were measured in PC12 cells and Drosophila brain tissue. (sdbonline.org)
  • GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)
  • Nat Cell Biol 24:1642-1654, 2022 (highlighted by News and Views "PTEN checkMAITs type-17 innate-like T cells" in the same issue). (stjude.org)
  • Anat Cell Biol. (koreamed.org)
  • Mol Biol Cell. (bdbiosciences.com)
  • Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
  • Thus, in B cells HDAC7 is a transcriptional repressor of undesirable genes. (eur.nl)
  • mRNA microarray analyses of A549, PC14, and PC14CDDP cells that were transiently transfected with either pre-miR-197 or LNA-miR-197 and their controls. (nih.gov)
  • Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. (mdpi.com)