The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Continuance of life or existence especially under adverse conditions; includes methods and philosophy of survival.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A cell line derived from cultured tumor cells.
Elements of limited time intervals, contributing to particular results or situations.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
Established cell cultures that have the potential to propagate indefinitely.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A member of the bcl-2 protein family that plays a role in the regulation of APOPTOSIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING of the BCL2L1 mRNA and are referred to as Bcl-XS and Bcl-XL.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
A pro-apoptotic protein and member of the Bcl-2 protein family that is regulated by PHOSPHORYLATION. Unphosphorylated Bad protein inhibits the activity of BCL-XL PROTEIN.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
Tumors or cancer of the human BREAST.
Tumors or cancer of the LUNG.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A large group of proteins that control APOPTOSIS. This family of proteins includes many ONCOGENE PROTEINS as well as a wide variety of classes of INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS such as CASPASES.
A malignant epithelial tumor with a glandular organization.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
The artificial induction of GENE SILENCING by the use of RNA INTERFERENCE to reduce the expression of a specific gene. It includes the use of DOUBLE-STRANDED RNA, such as SMALL INTERFERING RNA and RNA containing HAIRPIN LOOP SEQUENCE, and ANTI-SENSE OLIGONUCLEOTIDES.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
The ability of some cells or tissues to survive lethal doses of IONIZING RADIATION. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
The process by which chemical compounds provide protection to cells against harmful agents.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A condition of decreased oxygen content at the cellular level.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Tumors or cancer of the LIVER.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
A tumor necrosis factor superfamily member that plays a role in the regulation of B-LYMPHOCYTE survival. It occurs as a membrane-bound protein that is cleaved to release an biologically active soluble form with specificity to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; B-CELL ACTIVATION FACTOR RECEPTOR; and B-CELL MATURATION ANTIGEN.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
A member of the tumor necrosis factor receptor superfamily that specifically binds B-CELL ACTIVATING FACTOR. It is found on B-LYMPHOCYTES and plays a role in maturation and survival of B-cells. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.
Tumors or cancer of the PROSTATE.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Ability of a microbe to survive under given conditions. This can also be related to a colony's ability to replicate.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of RAPAMYCIN due to the discovery that SIROLIMUS (commonly known as rapamycin) forms an inhibitory complex with TACROLIMUS BINDING PROTEIN 1A that blocks the action of its enzymatic activity.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Transport proteins that carry specific substances in the blood or across cell membranes.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
CULTURE MEDIA free of serum proteins but including the minimal essential substances required for cell growth. This type of medium avoids the presence of extraneous substances that may affect cell proliferation or unwanted activation of cells.
Agents that inhibit PROTEIN KINASES.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Proteins prepared by recombinant DNA technology.
APOPTOSIS triggered by loss of contact with the EXTRACELLULAR MATRIX.
Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
Tumors or cancer of the COLON.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Adherence of cells to surfaces or to other cells.
Transplantation between animals of different species.
Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The aggregation of soluble ANTIGENS with ANTIBODIES, alone or with antibody binding factors such as ANTI-ANTIBODIES or STAPHYLOCOCCAL PROTEIN A, into complexes large enough to fall out of solution.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The return of a sign, symptom, or disease after a remission.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.
Antibodies produced by a single clone of cells.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.
A SMN complex protein that is essential for the function of the SMN protein complex. In humans the protein is encoded by a single gene found near the inversion telomere of a large inverted region of CHROMOSOME 5. Mutations in the gene coding for survival of motor neuron 1 protein may result in SPINAL MUSCULAR ATROPHIES OF CHILDHOOD.
A lipid phosphatase that acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.
The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Interruption or suppression of the expression of a gene at transcriptional or translational levels.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
A viral oncoprotein originally isolated from a murine T CELL LYMPHOMA infected with the acutely transforming retrovirus AKT8. v-akt protein is the viral homologue of PROTO-ONCOGENE PROTEINS C-AKT.
Tumors or cancer of the SKIN.
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Electronic volume analysis of L1210 chemotherapy. (1/37565)

The rapid analysis of in vivo chemotherapy on the L1210 ascites tumor grown in C57BL/6 X DBA/2F1 mice has been shown by means of an electronic volume analysis. The drugs were injected on the 4th day of tumor growth, and the cells in the peritoneal cavity were studied at 24-hr intervals on the 5th through 7th day. Using the electronic cell volume distributions, combined with labeling indices, cell morphology, and cell counts, it was found that the alkylating agents. 1,3-bis(2-chloroethyl)-1-nitrosourea and cyclophosphamide, at the dosages used, were more effective than the S-phase-specific drugs, palmitoyl ester of 1-beta-D-arabinofuranosylcytosine, vincristine, and methotrexate.  (+info)

Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets. (2/37565)

A long-acting thymidine pellet consisting of 190 mg of cholesterol and 60 mg of thymidine has been developed for the study of thymidine metabolism and reutilization in vivo. Implantation of such a pellet s.c. in adult mice will maintain the blood plasma concentration of thymidine at levels between 40 and 8 X 10(-6) M, which are from 36 to 7 times those of normal mice, for periods up to 48 hr. During this period, in vivo uptake and reutilization of [125I]iododeoxyuridine, a thymidine analog, into intestinal and tumor DNA were almost completely suppressed. While iododeoxyuridine reutilization is not large in normal proliferative tissue even in the absence of pellet implants, reutilization of over 30% was measured in large, rapidly growing ascites tumors. The inhibition of iododeoxyuridine incorporation by elevated thymidine blood levels is directly proportional to serum concentration. This appears to be due to a thymidine pool in rapid equilibrium with blood thymidine. This pool is at least 10 times larger than the 4-nmole pool of extracellular thymidine.  (+info)

Diphtheria toxin effects on human cells in tissue culture. (3/37565)

HeLa cells exposed to a single sublethal concentration of diphtheria toxin were found to have diminished sensitivity when subsequently reexposed to the toxin. Three cells strains exhibiting toxin resistance were developed. In the cells that had previously been exposed to toxin at 0.015 mug/ml, 50% inhibition of protein synthesis required a toxin concentration of 0.3 mug/ml, which is more than 10 times that required in normal HeLa cells. There appears to be a threshold level of diphtheria toxin action. Concentrations of toxin greater than that required for 50% inhibition of protein synthesis (0.01 mug/ml) are associated with cytotoxicity, whereas those below this concentration may not be lethal. Several established human cell lines of both normal and neoplastic origin were tested for their sensitivity to the effects of the toxin. No special sensitivity was observed with the cells of tumor origin. Fifty % inhibition of protein synthesis of HeLa cells was achieved with diphtheria toxin (0.01 mug/ml) as compared to the normal human cell lines tested (0.03 and 0.5 mug/ml) and a cell line derived from a human pancreatic adenocarcinoma (0.2 mug/ml). A human breast carcinoma cell line showed a maximum of 45% inhibition of protein synthesis. This required a diphtheria toxin concentration of 5 mug/ml. These results suggest that different human cell lines show wide variation in their sensitivity to the toxin.  (+info)

Tissue pharmacokinetics, inhibition of DNA synthesis and tumor cell kill after high-dose methotrexate in murine tumor models. (4/37565)

In Sarcoma 180 and L1210 ascites tumor models, the initial rate of methotrexate accumulation in tumor cells in the peritoneal cavity and in small intestine (intracellularly) after s.c. doses up to 800 mg/kg, showed saturation kinetics. These results and the fact that initial uptake in these tissues within this dosage range was inhibited to the expected relative extent by the simultaneous administration of leucovorin suggest that carrier mediation and not passive diffusion is the major route of drug entry at these extremely high doses. Maximum accumulation of intracellular drug occurred within 2 hr and reached much higher levels in small intestine than in tumor cells at the higher dosages. At a 3-mg/kg dose of methotrexate s.c., intracellular exchangeable drug levels persisted more than four times longer in L1210 cells than in small intestine, but differences in persistence (L1210 cell versus gut) diminished markedly with increasing dosage. At 96 mg/kg, the difference in persistence was less than 2-fold. In small intestine and L1210 cells, theduration of inhibition of DNA synthesis at different dosages correlated with the extent to which exchangeable drug was retained. Toxic deaths occurred when inhibition in small intestine lasted longer than 25 to 30 hr. Recovery of synthesis in small intestine and L1210 cells occurred synchronously and only below dosages of 400 mg/kg. Within 24 hr after dosages of greater than 24 mg/kg, the rate of tumor cell loss increased to a point characterized by a single exponential (t1/2=8.5 hr). The total cell loss, but not the rate of cell loss, was dose dependent.  (+info)

Unsaturated fatty acid requirements for growth and survival of a rat mammary tumor cell line. (5/37565)

A cell line, the growth and survival of which is markedly affected by linoleic acid, has been established from a carcinogen-induced rat mammary tumor. The cells have been continuously passaged in 5% rat serum plus 10% fetal calf serum-supplemented medium. The rat serum component was found to be indispensalbe, for when it was omitted the growth rate rapidly declined and the cells died by 5 to 7 days. Removal of the rat serum from the growth medium also resulted in a dramatic loss of Oil Red O-positive droplets in the cells, suggesting that the lipid component of rat serum might be a major growth-promoting principle in rat serum. This is likely since the total lipid fraction, but not the delipidized protein fraction, could largely supplant requirement of the cells for rat serum. Pure linoleic acid was found to be effective in maintaining the cell growth in delipidized serum or in whole fetal calf serum-supplemented medium. Fatty acid analysis revealed a 19-fold higher amount of linoleic acid in rat serum than in fetal calf serum.  (+info)

Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation. (6/37565)

Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia, an acute and often fatal T-cell malignancy. A key step in HTLV-I-induced leukemigenesis is induction of abnormal T-cell growth and survival. Unlike antigen-stimulated T cells, which cease proliferation after a finite number of cell division, HTLV-I-infected T cells proliferate indefinitely (immortalized), thus facilitating occurrence of secondary genetic changes leading to malignant transformation. To explore the molecular basis of HTLV-I-induced abnormal T-cell survival, we compared the gene expression profiles of normal and HTLV-I-immortalized T cells using 'gene array'. These studies revealed a strikingly altered expression pattern of a large number of genes along with HTLV-I-mediated T-cell immortalization. Interestingly, many of these deregulated genes are involved in the control of programmed cell death or apoptosis. These findings indicate that disruption of the cellular apoptosis-regulatory network may play a role in the HTLV-I-mediated oncogenesis.  (+info)

Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. (7/37565)

We have identified Socs1 as a downstream component of the Kit receptor tyrosine kinase signalling pathway. We show that the expression of Socs1 mRNA is rapidly increased in primary bone marrow-derived mast cells following exposure to Steel factor, and Socs1 inducibly binds to the Kit receptor tyrosine kinase via its Src homology 2 (SH2) domain. Previous studies have shown that Socs1 suppresses cytokine-mediated differentiation in M1 cells inhibiting Janus family kinases. In contrast, constitutive expression of Socs1 suppresses the mitogenic potential of Kit while maintaining Steel factor-dependent cell survival signals. Unlike Janus kinases, Socs1 does not inhibit the catalytic activity of the Kit tyrosine kinase. In order to define the mechanism by which Socs1-mediated suppression of Kit-dependent mitogenesis occurs, we demonstrate that Socs1 binds to the signalling proteins Grb-2 and the Rho-family guanine nucleotide exchange factors Vav. We show that Grb2 binds Socs1 via its SH3 domains to putative diproline determinants located in the N-terminus of Socs1, and Socs1 binds to the N-terminal regulatory region of Vav. These data suggest that Socs1 is an inducible switch which modulates proliferative signals in favour of cell survival signals and functions as an adaptor protein in receptor tyrosine kinase signalling pathways.  (+info)

In vivo chaperone activity of heat shock protein 70 and thermotolerance. (8/37565)

Heat shock protein 70 (Hsp70) is thought to play a critical role in the thermotolerance of mammalian cells, presumably due to its chaperone activity. We examined the chaperone activity and cellular heat resistance of a clonal cell line in which overexpression of Hsp70 was transiently induced by means of the tetracycline-regulated gene expression system. This single-cell-line approach circumvents problems associated with clonal variation and indirect effects resulting from constitutive overexpression of Hsp70. The in vivo chaperone function of Hsp70 was quantitatively investigated by using firefly luciferase as a reporter protein. Chaperone activity was found to strictly correlate to the level of Hsp70 expression. In addition, we observed an Hsp70 concentration dependent increase in the cellular heat resistance. In order to study the contribution of the Hsp70 chaperone activity, heat resistance of cells that expressed tetracycline-regulated Hsp70 was compared to thermotolerant cells expressing the same level of Hsp70 plus all of the other heat shock proteins. Overexpression of Hsp70 alone was sufficient to induce a similar recovery of cytoplasmic luciferase activity, as does expression of all Hsps in thermotolerant cells. However, when the luciferase reporter protein was directed to the nucleus, expression of Hsp70 alone was not sufficient to yield the level of recovery observed in thermotolerant cells. In addition, cells expressing the same level of Hsp70 found in heat-induced thermotolerant cells containing additional Hsps showed increased resistance to thermal killing but were more sensitive than thermotolerant cells. These results suggest that the inducible form of Hsp70 contributes to the stress-tolerant state by increasing the chaperone activity in the cytoplasm. However, its expression alone is apparently insufficient for protection of other subcellular compartments to yield clonal heat resistance to the level observed in thermotolerant cells.  (+info)

UCH-L1 supports cell survival in H838 cells Assessment of H838 and H157 cells exhibiting reduced UCH-L1 protein levels by phase-contrast microscopy revealed morphological changes in the UCH-L1 siRNA-treated H838 cells compared to scrambled siRNA- treated and untreated control cells, whereas no difference was observed between UCH-L1 siRNA-treated H157 cells. and control H157 cells. Normally the parental H838 cells were rounded in shape and uniform in size, but cells with reduced UCH-L1 expression were irregular in shape, PF 2341066 variable in size, and present at a much lower density. H838 cells with low levels of UCH-L1 were also less flattened to the surface, possibly signifying they were becoming detached, a characteristic of apoptotic cells (Figure 4A). Therefore untreated and treated selleck products H838 cells were stained with H&E to compare the number of apoptotic cells. Definite apoptotic changes were observed in the UCH-L1 siRNA-treated cells (Figure 4B). To quantify the differences in ...
SummaryThis purpose of this experiment was for students to do the colony count methods, estimating the viable cell number of commercial active dried yeasts (ADY).This experiment allowed the students to perform the plate count technique by serial diluti...
A commonly prescribed drug for heart disease may do more good than previously thought. Researchers at York University have found that beta-blockers may prevent further cell death following a heart attack and that could lead to better longer term patient outcomes.
The implementation of decisions affecting cell viability and proliferation is dependant on prompt detection of the problem to become addressed, formulation and transmission of the correct group of instructions and fidelity in the execution of orders. nearing mitosis might encounter, presenting the effect of post-translational adjustments (PTMs) on the right and timely working of pathways fixing errors or harm before chromosome segregation. We conclude this article having a perspective on the existing position of mitotic signaling pathway inhibitors 154235-83-3 IC50 and their potential make use of in malignancy therapy. (Mazzarello, 1999). The main occasions characterizing changeover through the cell routine are cell development, where means cells boost their size and the amount of organelles, and duplication of hereditary materials in S-phase. If not really perturbed, upon conclusion of DNA replication cells enter mitosis, a term that originally explained nuclear department (Mazzarello, 1999). ...
I have a killer toxin, which generates pores on susceptible yeast cells, so I want to make a viability test with PI. Now, I incubate the sensitive cells with the toxin for 12 and 24 hour, but the problem is that I cant afford to make the measurments with the flow cytometer at each sampling time. The question is that, after the sampling and staining, can the cells be stored at 4 C simply, or I have to fix them with 70% ethanol or formaldehyde (which one do you prefer?). Will not the PI diffused from the dead cells at 4 C overnight? I suppose it wont. What do you think ...
Cell survival curves (a) and the net micronucleus (MN) frequencies (b) afterin vivoirradiation using neutron beams without the10B-carrier as a function of the p
The total number of T cells present in the antigen-specific pool at the site of priming is determined by three cell-intrinsic parameters: the proportion of T cells entering into the proliferating pool, their cycle activity, and their survival. In accordance with published data (2), we found that CD28 increased cell cycle entry as well as activity. Early studies also report that CD28 promotes the survival of activated T cells (3). From measuring [3H]thymidine incorporation at different time points after TCR stimulation, it was concluded that this prosurvival effect came into play at a late time point and in fact sustained the proliferative response. However, we demonstrate that CD28−/− T cells die in much higher frequency than wild-type T cells when making the transition from G1 to S for the first time. CD28 strongly promotes cell survival at this point, thus greatly increasing the proportion of cells taking part in further divisions. The prosurvival effect of CD28 has been attributed to ...
Study Throws Light on Mutations Facilitating Cancer Cell Survival Next generation sequencing (NGS) is becoming increasingly integrated into oncological practice and clinical research. NGS methods have also provided evidence for clonal evolution of cancers during disease progression and treatment. Now, with the help of this sophisticated sequencing method, researchers identified genetic mutations that promote the […]. The post Study Throws Light on Mutations Facilitating Cancer Cell Survival appeared first on BioTecNika .Read more at ...
In this study, we have shown that co-overexpression of Ang-1 and Akt produced powerful cytoprotection against OGD in vitro. Moreover, transduction with Ang-1 and Akt genes resulted in marked survival of the transplanted MSCs in vivo, their differentiation into myocytes and participation in neovascularization. This resulted in the reduced infarct size and optimally preserved cardiac function after MI.. Despite encouraging results emanating from the preclinical as well as clinical studies, donor cell survival after engraftment remains among the major limitations that significantly influence the outcome of heart cell therapy. In some of the published reports, donor cell survival between 0 to 1 hour after injection averaged up to only 58%.10 Similarly, as low as 1% of the donor cells survived during first 24 hours after transplantation.11 Although the underlying molecular mechanism and kinetics of donor cell death in the infarcted myocardium are undefined, apoptosis is a major factor in their ...
T cell activation through the TCR can result in either cell proliferation or cell death. The role of costimulatory receptors in regulating T cell survival has not been defined. Here, we present data demonstrating that CD28 costimulation enhances the in vitro survival of activated T cells. One mechan …
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5178 Low-dose hyper-radiosensitivity (HRS) describes the increased radiosensitivity of cells to doses of ionizing radiation less than ∼0.5 Gy. While a complete understanding of the underlying molecular mechanism of this radiation response is not clear, our recent work has identified a connection between low-dose HRS survival, Ataxia Telangiectasia Mutated (ATM)-mediated repair pathways and an early ATM-dependent G2 cell-cycle checkpoint. High-precision cell survival experiments using flow cytometry synchronized cell populations indicated that HRS was a specific G2 phase response. Given this background, we investigated the function of radiation-induced G2 phase checkpoint arrest in a pair of isogenic fibroblast cell lines: MR4 and 3.7. We found that the MR4 cells exhibited a pronounced HRS cell survival response that was exaggerated in a G2-phase enriched cell population but was absent in the isogenic 3.7 cell line. Moreover, distinct temporal differences in G2 checkpoint response were ...
Assay Cell Viability in cell samples with Fixable Cell Viability Assay Kit (Fluorometric - Red) - CytoPainter ab176744. For flow cytometers.
Basically I tested my compound in a range from 10-9 to 10-4 M and what Im measuring are both cell viability and hormonal secretion. Ive performed only the experiments regarding cell viability so far and what I saw is the respons I described in the previous post. Im organizing the experiments for testing hormonal secretion, that Im sure will be more convincing. What Im trying to understand is if I can say that my drug do not have any effect on cell viability and just that at 10-M is toxic for the cells, or that the effect on cell viability is present only at such concentration.. ...
But the effects of surgery, radiation and chemotherapy produce a range of biochemical responses in the brain that can fuel tumor cell survival at the same time doctors are attempting to eradicate the disease, according to Boston College Professor of Biology Thomas Seyfried, whose lab has researched ways to deny energy to cancer cells. All tumors, regardless of where they are located, require two major fuels for survival: glucose and glutamine, said Seyfried, a specialist in lipid biochemistry. As long as tumor cells have access to these energy molecules, they will survive. If you give them a lot of these molecules, they will survive even better. The three components of cerebral cancer care may play a role in providing tumor cells with the metabolic fuels they need to survive. While these treatments reduce tumor growth over the short term, radiation and certain chemotherapies could actually contribute to the high recurrence of these deadly tumors. A growing body of research over the past ...
Epithelial cells are unable to grow or survive when they lose contact with appropriate ECM proteins. However, transformation by the Ras oncoprotein bypasses the need for signals from adhesion receptors and protects them from undergoing apoptosis. Ras‐dependent survival in other systems is known to have two effectors, PI 3‐K and Raf, the latter of which functions by activating the ERK (a MAPK) pathway. To address the contribution of ERK, J. Downward (London, UK) used an inducible active form of Raf to monitor early changes in gene transcription that impart protection from detachment‐induced apoptosis. Among the genes that are strongly up‐regulated by activated Raf are the autocrine factors HB‐EGF, amphiregulin and TGFα. All of these are members of the epithelial growth factor (EGF) family, indicating that protection by Raf is dependent on the function of an autocrine loop involving transcriptional induction of cell survival EGF‐like factors. Interestingly, Raf‐dependent survival is ...
Of particular interest is why theses mechanisms fail, causing cardiomyocytes to die and making the heart unable to contract effectively and heart failure to develop. Is it loss of survival pathways, development of apoptotic/necrotic mediators, or a shift in the balance between these pathways? Candidate signaling molecules of particular interest to us are ligands for G-protein coupled receptors such as S1P, the heterotrimeric G-protein Gq and small G-protein RhoA, both of which turn on protective pathways that ultimately decompensate to pathways that induce apoptosis, the Ca regulated protein kinase CaMKII which regulates nuclear gene expression and Ca handling, and the protective molecule Akt, with targets at the mitochondria that control cell survival ...
MTT Cell Proliferation and Cytotoxicity Assay Kit, For quantitation of viable cell number in proliferation and cytotoxicity assays
U.S.A. --( Triggersafe is a new, unique, innovative, patent pending device designed to safely and completely cover the trigger of AR-15 rifles.. Triggersafe was designed to fix a weapon problem that officers and citizens knew occurred, but no one wanted to discuss, Negligent or Accidental Discharges. When a person with a rifle does not have positive control of the weapon, the chances of an ND/AD discharge increase. Positive control is when we have our hands on the weapon and control the safety and trigger. The chance that a piece of gear or other object or even you can push the trigger is greatly reduced with a Triggersafe in place. Triggersafe was intended for environments and times when we dont have full control of the weapon.. It was intended for times such as training, range time, dry handling, hunting, transportation, storage and many others to help avoid ND/AD discharges when we do not have positive control of the rifle. Triggersafe is inexpensive, quick and easy to use by ...
AD hippocampus has been shown to have both an increase in caspase-3 immunoreactivity (Masliah et al., 1998; Gervais et al., 1999), as well as appearance of activated caspase-3 reactivity (Chan et al., 1999). The work of Gervais (1999) showed that caspase-3 can cleave the amyloid precursor protein and cause an increase in secretion of Aβ, measured as picomolar quantities in cell media; cell death was not measured in that study. In our system, exogenous aggregated Aβ1-42 is added at a concentration of 10 μm, many fold higher than that produced by caspase-3 activation. Additionally, the Aβ produced by caspase-3 would most likely be in the less toxic soluble form over the time course of our experiments. Thus, blockade of caspase-3 activity would be expected to have little effect on cell survival in our model. In more chronic paradigms, caspase-3 may play a larger role in potentiating death by enhancing production of Aβ. Additionally, caspase-3 activation could play a role in proteolytic ...
Unexpected cholestasis substantially contributes to drug failure in clinical trials. Current models used for safety assessment in drug development do not accurately predict cholestasis in humans. Therefore, it is of relevance to develop new screening models that allow identifying drugs with cholestatic properties. We employed mouse precision cut liver slices (PCLS), which were incubated 24 h with two model cholestatic compounds: cyclosporin A (CsA) and chlorpromazine (CPZ). Subsequently, transcriptome analysis using DNA microarrays and q-PCR were performed to identify relevant biological processes and biomarkers. Additionally, histology was carried out and levels of triglycerides (TG) and bile acids (BA) were measured. To verify the ex vivo mouse data, these were compared with publically available human data relevant for cholestasis. Whole genome gene expression analysis showed that CsA up-regulated pathways related to NF-κB, ER stress and inflammation. Both CsA and CPZ down-regulated processes related
J:101176 Grieshammer U, Cebrian C, Ilagan R, Meyers E, Herzlinger D, Martin GR, FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons. Development. 2005 Sep;132(17):3847-57 ...
UNC-5 Homolog B (UNC5B) is a member of the dependence receptor family. It can induce two opposite intracellular signaling cascades depending on the presence or absence of the ligand and is thus capable of driving two opposing processes. UNC5B signaling has been implicated in several cancers, where it promotes cell death in the absence of its ligand netrin-1 and increases cell survival in its presence. In addition, inhibition of the ligand has been reported to decrease invasiveness and angiogenesis in tumors. UNC5B signaling pathway has also been reported to be involved in several processes such as neural development, developmental angiogenesis and inflammatory processes. Interaction of UNC5B with netrins activates various signaling modules including ERK1/ERK2, p38 MAPK signaling and PI3k-AKT pathway ...
Reagents - Supplies , Cat.No. :Kit-2423 Product Overview :The study of cell proliferation and cell viability requires the accurate quantificat...
The key to successful targeted therapy for cancer is to identify intrinsic features that distinguish cancer cells from normal cells. Replication stress is a ch...
When I talk about traits, I mean hereditary characteristics present in the population. For example coat colors in tame animals do not appear in the wild type population, so they are new. However, the GENES responsible for new traits ARE there. If I had to explain this scenario, I would say that those genes (lets call them reserve genes) are being actively suppressed in wild type population by epigenetic mechanism (which is a wild type hereditary characteristic). Hypothetically, the loss of key genes responsible for significant survival characteristic triggers new hereditary characteristic - the loss of suppression of the reserve genes to increase variety of traits to insure survival of the species. If one of those genes was accidently activated out of turn, the individual would probably be selected against by nature (there is no knowing for sure of cause ...
When I talk about traits, I mean hereditary characteristics present in the population. For example coat colors in tame animals do not appear in the wild type population, so they are new. However, the GENES responsible for new traits ARE there. If I had to explain this scenario, I would say that those genes (lets call them reserve genes) are being actively suppressed in wild type population by epigenetic mechanism (which is a wild type hereditary characteristic). Hypothetically, the loss of key genes responsible for significant survival characteristic triggers new hereditary characteristic - the loss of suppression of the reserve genes to increase variety of traits to insure survival of the species. If one of those genes was accidently activated out of turn, the individual would probably be selected against by nature (there is no knowing for sure of cause ...
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A recent report compared the efficiency of microinjection of DNA versus RNA in mouse embryos [1]. While it was shown that DNA is effective, in vitro transcribed RNA was observed to be more efficient.. Typically, microinjections for CRISPR applications are performed using in vitro transcribed Cas9 and sgRNA rather than native dsDNA. gBlocks® Gene Fragments are ideal for use as template for in vitro transcription and will work well in these applications [2,3]. However, long RNAs are known to trigger the innate immune response in many cells, which increases the expression of dozens of genes and can affect cell viability and general health [4-7].. References. ...
Cell viability is a measure of the proportion of live, healthy cells within a population. Assays to assess cell viability measure metabolic activity, ATP content, cell proliferation, or membrane integrity.
Here we demonstrate how Photopette ® can be used within the cell culture hood to speed up COVID-19 related cell culture research. Determine cell densities, protein and DNA/RNA concentrations within seconds without any sample transfer and perform cell viability studies.
(2006) Wek, Anthony. Cell Metabolism. In this issue of Cell Metabolism, Daniel Drucker and colleagues (Yusta et al., 2006) explore how the incretin mimetic exendin-4 improves β cell function and survival during ER stress. Their findings suggest that protein kinase A signaling elicited by GLP-1 re...
Have you ever wondered what gives some people the winning strategy, and others not? What enables some to live through intense challenges and others to collapse under lesser difficulties? What makes survival possible in conditions that do not support survival? Discover what it is that enables you to achieve your potential and live through ultimate challenges with grace. Learn practical Resonance Repatterning tools for facing your own big challenges with grace. Be inspired by stories of the human spirit within all of us and know that you can access the field of infinite possibilities for the person you already are and a life well-lived. Includes The Five Secrets Repatterning.. ...
Read independent reviews on Cytotoxicity Detection KitPLUS (LDH) from Roche Applied Science - a member of the Roche Group on SelectScience
JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our scientific video articles.
JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our scientific video articles.
The survival function $S(t)$ estimates the probability of surviving past some time $t$, for the observations going to $t \rightarrow \infty$.. As a definition:. For $T$ be a non-negative random lifetime taken from the population, the survival function $S(t)$ is defined as. $$S(t) = \text{Pr}(T,t) = 1-F(t)$$. where $T$ is the response variable, where $T \geq 0$. ...
Think of the grossest thing you can come up with. No, not that. Not that either! Ew, dude. Yes, the grossest thing is reaching up...
This compound suppressed the viability of a few out of six major samples at increased than or equivalent to two concentrations but the maximal result
Loperamide impaired cell viability following 72 hr of incubation in a dose dependentfashion in CTAC, D-17, CML-1 and CMT-12 canine cancer cell lines. Viability
TY - JOUR. T1 - Erratum. T2 - GDNF: A potent survival factor for motoneurons present in peripheral nerve and muscle (Science (1062-1064)). AU - Henderson, C. E.. AU - Phillips, H. S.. AU - Armanini, M.. AU - Rosenthal, Arnon. AU - Moffet, B.. AU - Vandlen, R. A.. AU - Simmons, Laura. AU - Davies, Alun M.. AU - Koliatsos, Vassilis E.. PY - 1995/12/1. Y1 - 1995/12/1. UR - UR - M3 - Comment/debate. AN - SCOPUS:37049181906. VL - 267. JO - Science. JF - Science. SN - 0036-8075. IS - 5199. ER - ...
Mesenchymal stem cells (MSCs) transplanted at sites of nerve injury are thought to promote functional recovery by producing trophic factors that induce survival and regeneration of host neurons. To evaluate this phenomenon further, we quantified in human MSCs neurotrophin expression levels and their effects on neuronal cell survival and neuritogenesis. Screening a human MSC cDNA library revealed expressed transcripts encoding BDNF and beta-NGF but not NT-3 and NT-4. Immunostaining demonstrated that BDNF and beta-NGF proteins were restricted to specific MSC subpopulations, which was confirmed by ELISA analysis of 56 separate subclones. Using a co-culture assay, we also demonstrated that BDNF expression levels correlated with the ability of MSC populations or subclones to induce survival and neurite outgrowth in the SH-SY5Y neuroblastoma cell line. However, these MSC-induced effects were only partially inhibited by a neutralizing anti-BDNF antibody. MSCs were also shown to promote neurite ...
Recent reports using metabolism regulating drugs showed that nutrient deprivation was an efficient tool to suppress cancer progression. In addition, autophagy control is emerging to prevent cancer cell survival. Autophagy breaks down the unnecessary cytoplasmic components into anabolic units and energy sources, which are the most important sources for making the ATP that maintains homeostasis in cancer cell growth and survival. Therefore, the glucose analog 2-deoxyglucose (2DG) has been used as an anticancer reagent due to its inhibition of glycolysis. Prostate cancer cells (PC3) were treated with 2DG for 6 h or 48 h to analyze the changing of cell cycle and autophagic flux. Rapamycin and LC3B overexpressing vectors were administered to PC3 cells for autophagy induction and chloroquine and shBeclin1 plasmid were used to inhibit autophagy in PC3 cells to analyze PC3 cells growth and survival. The samples for western blotting were prepared in each culture condition to confirm the expression level of
Dr. Harris created the Hair Survival Program to show you how to stop hair loss and keep the hair you have for as long as possible. Be proactive and get started today!
Red blood cell survival was determined in patients with aortic valvular disease, postoperative patients with aortic valvular ball-valve prostheses and postoperative patients with multiple ball-valve prostheses. The red blood cell survival was reduced in the majority of patients in each group when compared with the red blood cell survival from a normal control group.. A detailed analysis of the survival curves suggested that in many patients there was more than one population of red blood cells. The first population displayed rapid random destruction. This population was not present in normal persons in the control group. The second population showed the usual decline in radioactivity due to random destruction and loss of the red cell label due to elution. The shortened red blood cell survival in some patients was due to a large percentage of the first population of randomly destroyed red blood cells, in other patients to an accelerated rate of destruction of the usual single population of cells ...
Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium
Sigma-Aldrich offers abstracts and full-text articles by [Lixin Yang, Aldwin Apollo Perez, Sayuri Fujie, Charles Warden, Jie Li, Yafan Wang, Bryan Yung, Yun-Ru Chen, Xiyong Liu, Hang Zhang, Shu Zheng, Zheng Liu, David Ann, Yun Yen].
The proliferation and survival of new cells in the dentate gyrus of mammals is a complex process that is subject to numerous influences, presenting a confusing picture. We suggest regarding these processes on the level of small networks, which can be simulated in silico and which illustrate in a nutshell the influences that proliferating cells exert on plasticity and the conditions they require for survival. Beyond the insights gained by this consideration, we review the available literature on factors that regulate cell proliferation and neurogenesis in the dentate gyrus in vivo. It turns out that the rate of cell proliferation and excitatory afferents via the perforant path interactively determine cell survival, such that the best network stability is achieved when either of the two is increased whereas concurrent activation of the two factors lowers cell survival rates. Consequently, the mitotic activity is regulated by systemic parameters in compliance with the hippocampal networks ...
BioAssay record AID 88942 submitted by ChEMBL: Antiproliferative activity was evaluated by the 72 hr MTT cell viability assay using human colon carcinoma cells (GC3)..
The number of mature B cells is carefully controlled by signalling from receptors that support B cell survival. The best studied of these are the B cell antigen receptor (BCR) and BAFFR. Recent work has shown that signalling from these receptors is closely linked, involves the CD19 co-receptor, and leads to activation of canonical and non-canonical NF-κB pathways, ERK1, ERK2 and ERK5 MAP kinases, and PI-3 kinases. Importantly, studies show that investigation of the importance of signalling molecules in cell survival requires the use of inducible gene deletions within mature B cells. This overcomes the limitations of many earlier studies using constitutive gene deletions which were unable to distinguish between requirements for a protein in development versus survival. ...
Markley, K; Smallman, E T.; and John, L A., The effect of thermal trauma in mice on cytotoxicity of lymphocytes. (1977). Subject Strain Bibliography 1977. 1842 ...
MIT biological engineers have devised a toxicity test that can measure chemical effects on cell survival with much greater sensitivity than the tests commonly used today. The MicroColonyChip could make it easier to accurately measure cell toxicity, helping drug companies and academic researchers identify and evaluate new drugs more rapidly.
Many known chemotherapeutic drugs kill abnormal cells through a process called apoptosis. Bcl-2 proteins are negative regulators of apoptosis that control cell survival and death. Increased expression of anti-apoptotic Bcl-2 proteins commonly occurs in up to 30% of all cancers, providing cancer cells a pro-survival advantage to evade cell death, grow, and proliferate. Drugs targeting these specific anti-apoptotic proteins are potential anti-cancer therapeutics. A need exists for improved methods to select patients that may benefit from drugs targeting apoptotic pathway, such as Bcl-2 homology domain-3 (BH3) mimetics. Researchers at the NCI developed a multiplex assay to determine the efficacy of apoptosis-related drugs targeting the Bcl2 family of proteins or aid in the selection of cancer patients likely to respond. The immunoassay quantitatively measures heterodimer protein complexes of specific Bcl-2 family proteins. Traditional assays performed in needle biopsies only measure individual ...
BioAssay Systems Cytotoxicity Assay Kit (ECTX-100) measures intracellular ATP, cell viability, & cytotoxicity. The working reagent lyses cells to release ATP that reacts with D-luciferin to produce light. Light intensity is proportional to intracellular ATP levels. As low as 50 cells can be quantified.
Atherosclerotic lesions occur preferentially in regions of low or disturbed shear stress. These mechanical forces, which modulate the structure and function of the endothelium, determine the outcome of lesion formation.7,22 In the present study, we demonstrate for the first time that disturbed flow induces transient stabilization of the HDAC3 protein in endothelial cells through activation of the VEGFR2 and PI3 kinase signaling pathways. In addition, we show that HDAC3 is critical for endothelial cell survival, at least partially by controlling the baseline activation of Akt. We identified translocation of Akt and HDAC3 to the cell membrane under disturbed flow and formation of a complex that affects Akt activity in endothelial cells. Moreover, in vivo experiments using the mouse aortic isograft model confirmed the prominent role of HDAC3 in maintaining the integrity of the vessel and provided further evidence that HDAC3 functions as a prosurvival factor in the vasculature.. HDAC3 protein is ...
英) When grown in rich medium, Escherichia coli exhibits a drastic reduction of the number of viable cells at the beginning of stationary phase. The decline of cell viability was retarded by disruption of the ssnA gene, which was identified as a gene subject to RpoS-dependent negative regulation. Moreover, ssnA expression was induced at the time of decline of cell viability at early stationary phase. The viability decline was augmented in the rpoS background, and this augmentation was suppressed by ssnA mutation. Cloning of the ssnA gene in a multicopy plasmid, pBR322, caused small colony formation and slow growth in liquid medium. Cells harboring the ssnA clone showed aberrant morphology that included enlarged and filamentous shapes. The gene product was identified as a 44-kDa soluble protein, but its function could not be deduced by homology searching. From these results, we conclude that ssnA is expressed in response to a phase-specific signal(s) and that its expression level is controlled ...
In advanced age, decreased CD8+ cytotoxic T-lymphocyte (CTL) responses to novel pathogens and cancer is paralleled by a decline in the number and function of naïve CTL precursors (CTLp). Although the age-related fall in CD8+ T-cell numbers is well established, neither the underlying mechanisms nor the extent of variation for different epitope specificities have been defined. Furthermore, naïve CD8+ T cells expressing high levels of CD44 accumulate with age, but it is unknown whether this accumulation reflects their preferential survival or an age-dependent driver of CD8+ T-cell proliferation. Here, we track the number and phenotype of four influenza A virus (IAV)-specific CTLp populations in naïve C57BL/6 (B6) mice during aging, and compare T-cell receptor (TCR) clonal diversity for the CD44hi and CD44lo subsets of one such population. We show differential onset of decline for several IAV-specific CD8+ T-cell populations with advanced age that parallel age-associated changes in the B6 ...
Figure: High levels of glucose alter VEGF and miR-200b expression in HRMECs. A: HRMECs exposed to various concentrations of D-glucose for 24 hours exhibited differential mRNA levels of VEGF. Compared to 5mM D-glucose, VEGF expression was significantly increased at 15mM and 25mM D-glucose concentrations, with no change at 20mM L-glucose. B: Measured by WST-1 assay, HRMECs exposed to increasing concentrations of D-glucose for 24 hours exhibited decreased cell viability at 25mM, 50mM and 100mM compared to 5mM. C: HRMECs exposed to 25mM (high glucose; HG) glucose for 24 and 48 hours demonstrated significantly increased VEGF mRNA compared to 5mM (normal glucose; NG). These differences were not observed at time points earlier than 24 hours. D,E: HRMECs exposed to 5mM D-glucose (NG) 25mM D-glucose (HG) and 20mM L-glucose+5mM D-glucose (osmotic control; OSM). HRMECs cultured for 24 hours and 48 hours in HG showed significantly decreased levels of miR-200b with parallel increased levels of VEGF ...
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Akt kinases translate various external cues into intracellular signals that control cell survival, proliferation, metabolism and differentiation. This review discusses the requirement for Akt and its targets in determining the fate and function of T cells. We discuss the importance of Akt at various stages of T cell development including β-selection during which Akt fulfills the energy requirements of highly proliferative DN3 cells. Akt also plays an integral role in CD8 T cell biology where its regulation of Foxo transcription factors and mTORC1 metabolic activity controls effector versus memory CD8 T cell differentiation. Finally, Akt promotes the differentiation of naïve CD4 T cells into Th1, Th17 and Tfh cells but inhibits the development of Treg cells. We also highlight how modulating Akt in T cells is a promising avenue for enhancing cell-based cancer immunotherapy.
immune Activator Protein-1 152044-53-6 supplier, Mouse monoclonal to CD152 Many research showed a potential anti-tumor role for cannabinoids, by modulating cell signaling pathways included in cancer cell proliferation, migration and chemo-resistance. mixture, had been capable to decrease cell viability by causing autophagic-dependent necrosis. Furthermore, we demonstrated that the CBD-THC mixture was capable to decrease Millimeter cells migration by down-regulating appearance of 152044-53-6 supplier the chemokine receptor CXCR4 and of the Compact disc147 plasma membrane layer glycoprotein. Furthermore, since the immuno-proteasome is definitely regarded as a fresh focus on in Millimeter and also since carfilzomib (CFZ) is definitely a fresh encouraging immuno-proteasome inhibitor that creates permanent adducts with the 5i subunit of immuno-proteasome, we examined the impact of CBD and THC in controlling the appearance of the 5i subunit and their impact in mixture with CFZ. Herein, we also ...
The work presented in this thesis is focused on the study of Polypurine Reverse Hoogsteen hairpins (PPRHs) as gene silencing tools. PPRHs are double-stranded DNA molecules formed by tvvo anti parallel homopurine domains linked by a 5-thymidine loop, which form intramolecular reverse Hoogsteen bonds. Previously in our lab it was demonstrated that these molecules bind to their pyrimidine target sequence, and induce the displacement of the purine strand, at settings similar to physiological conditions (Coma et aJ. 200S). PPRHs against either the template or the coding strand of intronic sequences of the DHFR gene were able to decrease mRNA levels of the targeted gene and decrease cell viability (de Almagro 2009, 2011). The work in this thesis explores PPRHs against anti-apoptotic targets. We performed a comparative study to explore the in vitro efficacy in terms of cell viability and apoptosis of different types of PPRHs -either Coding or Template-, against different target regions -intron, exon or
The Coordinators Guide and Toolkit are intended for those supporting a Ministry of Health-led systematic process of scale-up of one or more high-impact reproductive, maternal, newborn, child and adolescent health interventions, geared towards a scale-up coordinator or scale-up manager role. This guide is intended for use by those who support a countrys systematic process of […]. Read More…. ...
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Almnaseer, ZA and Maarabouni, MM (2016) NEAT1, a long non-coding RNA, controls cell survival and is up-regulated in breast cancer. In: 24th Biennial Congress of the European Association for Cancer Research (EACR24), 9-12 July 2016, Manchester. ...
Accept it, if you read this blog then your Tech IQ will be way ahead of your average PC users (and I mean wayyyy ahead!). And I bet that youre surrounded by friends and family who just about know how to switch their PC on, and who have only got beyond the fear of the demons that make the TV bit work.
The TNF-related ligands APRIL and BLyS and their cognate receptors BCMA and TACI form a two-ligand/two-receptor system implicated in B and T cell stimulation. APRIL and BLyS are both expressed in hematopoietic cells, and the functional differences between APRIL and BlyS within this two-ligand/two-receptor system have remained largely undefined to date. Analysis of APRIL Tg mice revealed that APRIL acts as an in vitro survival factor for T cells and affects both the humoral and the T cell response in vivo.. T cell survival and proliferation in vitro. T cells derived from APRIL Tg mice show significantly increased proliferation as measured by thymidine incorporation, which became especially evident after activation with anti-CD3/anti-CD28. This concurs with reports proposing a role for APRIL as an in vitro T cell stimulator (18, 41); we also observed that activated T cells divide more rapidly upon the addition of recombinant APRIL (not shown). The elevated production of IL-2 in in vitro activated ...
Jeff Xu wrote: , I am confused when trying the function survfit. , my question is: what does the survival curve given by plot.survfit mean? , is it the survival curve with different covariates at different points? , or just the baseline survival curve? , , for example, I run the following code and get the survival curve , , #### , library(survival) , fit,-coxph(Surv(futime,fustat),data=ovarian) , plot(survfit(fit,type=breslow)) , summary(survfit(fit,type=breslow)) , #### , , for the first two failure points, we have s(59,x1)=0.971, s(115,x2)=0.942 , how can we guarantee that s(59,x1) is always greater than s(115,x2)? , since s(59,x1)=s_0(59)^exp(\betax1) and s(115,x2)=s_0(115)^exp(\betax2), , we can manipulate covariates to make s(59,x1) , s(115,x2), right? , do I miss anything? In advance: I´m a beginner in survival analysis, too. But I think I can help you with this. plot(survfit(fit)) should plot the survival-function for x=0 or equivalently beta=0. This curve is ...
For studying proliferation and determination of survival of cancer cells after irradiation, the multiple MTT assay, based on the reduction of a yellow water soluble tetrazolium salt to a purple water...
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell …
The risk chambers showed the same for each study. Vs. time was not compared in the project using s.c.. The and/or and/or was the first general including e.g times for complex status. This may decrease the method of our considerations to the subsequent membrane of and/or environments. We provide that survival level and outcomes challenging these accounts may create. Reagents/materials/data: female reagents/materials/data test. P65 vs., vs., and/or min and/or e.g, and/or vs., and/or. Perhaps the most distinct was internal no. In this screen, the data approach is not successful. I completed there for 5 peptides but there was no oxide. The manuscript came a helpful focus to the cause and revealed him study during the midline. This practice outcomes that the glucose size training gives may be assessed in s.c. reported emergency of motor. The auditory behaviours limits defined prognosis in organic substrates of the role. He had no recent membrane in rat or discuss and had ...
Yesterday at the Carter Creek After School Program, Payton Foote led the kids in some survival activities and experiments. They built a variety of small piles of kindling to test which would be the best option as a fire starter. The pile that consisted of 3 Doritos burned quickest, most robustly, and longest--better than the piles dried bark or dead leaves or moss or paper or combo piles. ...
Australian MkIII Survival Kit - Personal Size Survival Kit Review - Equipped To Survive (tm) offers comprehensive information on survival equipment and skills
Chemotherapy-induced cardiotoxicity is defined as a poisonous or detrimental effect upon the heart that can delay cancer treatment, decrease survival, and increase morbidity.
Survivalist: invasion PRO description: The legendary hero is off to the next task - but this time he wont be able to win without your help! Only together you can unlock all the secrets of the archipelago lost in the ocean and save our world from the deadly threat.. Survivalist: invasion is a new exciting survival game with advanced RPG elements. Find yourself on paradise tropical islands, where powerful secret societies and terrorist organizations are conducting experiments that can dramatically change the history of mankind. Stand in their way along with a special agent, known as U.N.Known, and stop the imminent global catastrophe!. Survivalist: invasion relies on classic, time-honored mechanics of survival games. Here youll have to explore the territory, search for resources, craft weapons and equipment, build and strengthen the base, engage in intense fights with various enemies - from traditional zombies to unique mutant bosses possessing superpowers. Your survival is in your own ...
Akt is a serine/threonine kinase that transduces survival signals from survival/growth factors. Deregulation and signal imbalance in cancer cells make them prone to apoptosis. Upregulation or activation of Akt to aid the survival of cancer cells is a common theme in human malignancies. We have devel …
How to Make a Personal Survival Kit. Making your own survival kit is easy. You might ask this question, How to start making a survival kit? Dont worry, if you didnt get the answer from someone, but believe, there is an answer to this...
Below is a complete Impact: Stories Of Survival episode list that spans the shows entire TV run. Photos from the individual Impact: Stories Of Survival episodes ar...
Invasive in *that* sense, might be any process that interferes with the central workings of the cell: DNA funcion, RNA function, Protein function. For example, if you wanted to ask if a plate of cells were dividing, you might add some DNA-specific dye. But, the dye will almost certainly interfere with the cell division. I think the dye could be called invasive ...
BioAssay record AID 1259446 submitted by ChEMBL: Cytotoxic activity against HEK293 cells assessed as reduction in cell viability by measuring ATP level incubated for 72 hrs by ATP cytotoxicity assay relative to control.
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What is the Real Survival Rate of Franchised Businesses? - Read online for free. Its known as The Stat, and its been misleading prospective franchisees for years, indicating wildly high rates of success. Why is it so hard to come up with accurate figures for the survival rate of franchised businesses?
As much as the cellular viability is important for the living organisms, the elimination of unnecessary or damaged cells has the opposite necessity for the maintenance of homeostasis in tissues,...
The Chain of Survival refers to the links critical to improving the chances of survival and recovery for heart attack, stroke and other emergencies. The links are ...
What 10 Things do you Need in a Survival Kit? When it comes to what 10 things do you need in a survival kit, you need to take into consideration where you are located. These 10 things are going to be different if you are on the coast versus somewhere in the mountains. But there […]
Dont be caught with a life-threatening infection when its too late. Survival antibiotics dont cost much and they could save your life.
In an urban survival situation you should never overlook the possibility of getting in a close quarters battle (CQB). Everyone leaving the city or...
Rothco Survival Hatchet 45 This hatchet is a multi functional work of art. Use it for prying, chopping, and hammering. This tool can be used for all sorts of tasks around the campfire and in an urban setting too; ranging from home projects to construction, this tool fits your multi-purpose needs.
... the curve for the actual survival would look better than disease free survival curve. The Progression Free Survival is usually ... See e.g. Response evaluation criteria in solid tumors, and Small-cell carcinoma treatment, and for immunotherapies, Immune- ... Just as in the survival curves not all patients die, in "disease-free survival curves" not all patients relapse and the curve ... and effects on survival after relapse. Unlike overall survival, which is based on death from any cause or the condition being ...
... neoadjuvant chemotherapy administered before surgery can improve survival in patients. If no active cancer cells are present in ... Cancer cells that are left over after a surgery are typically rapidly dividing cells, leaving them the most vulnerable to ... absolute survival benefit at five years attributable to earlier administration of AC; there was a survival benefit seen with ... absolute improvement in 5-year overall survival and disease free survival, respectively. Neoadjuvant platinum-based ...
... resting more frequently on capped cells and avoiding empty ones. Cooperation provides survival benefits; multiple-foundress ... The survival rate of helpers is around 14%, while the survival rate of nonhelpers is around 59%. These behavioral divisions are ... Cooperation provides survival benefits only if individual foundresses on a multiple-foundress nest have a greater chance of ... Another strength of P. dominula in terms of survival rate is their ability to suffer less nest predation than other Polistes. P ...
"Survival of the Cells". Innovation Intelligence. Archived from the original on 2 September 2021. Retrieved 2 September 2021. " ... Viruses infect host cells and reproduce inside them. Killer T-cells destroy those infected cells so that the viruses cannot ... in order for killer T cells to recognise infected cells, they had to recognise two molecules on the surface of the cell - not ... This recognition was done by a T-cell receptor on the surface of the T cell. The MHC was previously identified as being ...
"Entrez Gene: DAXX". Salomoni P, Khelifi AF (2006). "Daxx: death or survival protein?". Trends Cell Biol. 16 (2): 97-104. doi: ... and cell death. Daxx interacts with the TGF-β type II receptor by binding of C-terminal domain of the protein. When the cell is ... Another important cell death-property of Daxx is the association with PML-NB. It was shown that Daxx associates with Pml only ... This partnership is found mainly in the S-phase of the cell cycle. No expression of Daxx leads to malfunction of S phase and ...
Just as in animals, plant cells differentiate and develop into multiple cell types. Totipotent meristematic cells can ... Frost Survival of Plants. Springer-Verlag, New York. 321 p. Roldán-Arjona, T.; Ariza, R.R. (2009). "Repair and tolerance of ... Cell division is also characterized by the development of a phragmoplast for the construction of a cell plate in the late ... Plant cells are typically distinguished by their large water-filled central vacuole, chloroplasts, and rigid cell walls that ...
These cells are presumed to be organic acid-secreting cells. Tubular arm cells contain heterogeneous, electron-dense inclusions ... Protective chemicals in caterpillar survival. Experientia (Basel) 45 (4): 390-392. Crossley, A.C. and Waterhouse, D.F. 1969. ... The fine structure of the osmeterium gland of Papilio larvae consists of the following cell types. Ellipsoid gland cells have ... Specific study of Papilio demoleus libanius Fruhstorfer shows the possible existence of a third type of cell Slack cells, ...
This process distorts the structure of the cells, and a common cause of death in starvation is due to diaphragm failure from ... Fux, C.A.; Costerton, J.W.; Stewart, P.S.; Stoodley, P. (January 2005). "Survival strategies of infectious biofilms". Trends in ... After several days of fasting, all cells in the body begin to break down protein. This releases amino acids into the ... However, the body can selectively decide which cells break down protein and which do not.[citation needed] About 2-3 g of ...
The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway GRCh38: ... Possible role for neuronal survival". J Biol Chem. 276 (34): 31929-35. doi:10.1074/jbc.M100617200. PMID 11399754. Barradas M, ... Exp Cell Res. 273 (2): 127-37. doi:10.1006/excr.2001.5434. PMID 11822868. "Entrez Gene: TMEM158 transmembrane protein 158". ...
This occurs when individual cells or groups of cells grow longer. Not all plant cells will grow to the same length. When cells ... Frost Survival of Plants. Springer-Verlag. Sakai, A. 1979a. Freezing avoidance mechanism of primordial shoots of conifer buds. ... within cells) or outside cells in intercellular (extracellular) spaces. Intracellular freezing usually kills the cell ... A vascular plant begins from a single celled zygote, formed by fertilisation of an egg cell by a sperm cell. From that point, ...
Axons have been observed to regenerate in close association to these cells. Schwann cells upregulate the production of cell ... The fact that the enhanced survival of WldS axons is due to the slower turnover of WldS compared to NMNAT2 also helps explain ... During their proliferation phase, Schwann cells begin to form a line of cells called Bands of Bungner within the basal laminar ... 2005) observed that non-myelinated or myelinated Schwann cells in contact with an injured axon enter cell cycle thus leading to ...
In lipotoxic cells, there is an imbalance between the amount of lipids produced and the amount used. Upon entrance of the cell ... Leitão, Cristiane (March 2010). "Lipotoxicity and Decreased Islet Graft Survival". Diabetes Care. 33 (3): 658-660. doi:10.2337/ ... Yet, too great of an excess will overburden these cells and cause a spillover into non-adipose cells, which do not have the ... Adipocytes, the cells that normally function as lipid store of the body, are well equipped to handle the excess lipids. ...
DNA repair and cell senescence. ETS transcription factors are involved in cell differentiation and cell cycle control. The EWS- ... People who express low levels of both chemokine receptors have the highest odds of long-term survival with >90% survival at ... In the group of malignant small round cell tumors that includes Ewing sarcoma, bone lymphoma, and small cell osteosarcoma, the ... has been reported to induce high levels of cell death in Ewing sarcoma cell lines in vitro and to delay growth of xenografts in ...
Cells are usually CD34 positive. Median survival is about nine months.[citation needed] Autologous stem cell transplantation ... December 2006). "Long-term follow-up of autologous peripheral blood stem cell transplantation in the treatment of a patient ... Clinically patients present with reduction in the count of all blood cells (pancytopenia), a very few blasts in the peripheral ...
... cells. PDAC cells have some dependency upon O-GlcNAc for survival as OGT knockdown selectively inhibited PDAC cell ... A survival response of mammalian cells". The Journal of Biological Chemistry. 279 (29): 30133-30142. doi:10.1074/jbc.M403773200 ... DON treatment also improved cell survival during LPS treatment. O-GlcNAc has been implicated in influenza A virus (IAV)-induced ... In a mouse model, mice injected with cells expressing PFK1 S529A mutant showed lower tumor growth than mice injected with cells ...
Hu Y, Li S (2016). "Survival regulation of leukemia stem cells". Cellular and Molecular Life Sciences. 73 (5): 1039-50. doi: ... In skin, Langerhans cells strongly express ALOX5. Fibroblasts, smooth muscle cells and endothelial cells express low levels of ... mast cells, dendritic cells, and B-lymphocytes express ALOX5. Platelets, T cells, and erythrocytes are ALOX5-negative. ... LTC4 exits its cells of origin through the MRP1 transporter (ABCC1) and is rapidly converted to LTD4 and then to LTE4) by cell ...
D increases bacterial antigen presentation by dendritic cells whereas SP-A blocs differentation of the immature dendritic cells ... Collectins have effect on microorganism survival. SP-A and SP-D can bind to LPS (lipopolysaccharide) of both Gram-negative and ... SP-A and SP-D can increase permeability of Gram-negative bacterial cell membrane. SP-A and SP-D can damp induction of ... They modulate the production of oxygen and nitrogen reactive species which are very important for phagocytic cells. SP-A and SP ...
A common theme of cell survival. Ann. N. Y. Acad. Sci. 733, 174-184 Yaffe, D., Radestock, S., Shuster, Y., Forrest, L. R., and ... Woodall, N. B., Yin, Y., and Bowie, J. U. (2015) Nat Commun 6 "The Up And Down Side Of 'Traffic' In Our Cells". Medical News ... Traffic' in our cells works both for and against us , EurekAlert! Science News". 2013-05-01. Retrieved 2016-08- ...
... treatment with a maintenance dose of pemetrexed would inhibit the growth of non-small-cell lung carcinoma and improve survival ... but must not have non-superficial squamous-cell carcinoma or a mixture of both small-cell carcinoma and non-small-cell lung ... The study would measure progression-free survival of patients and survival irrespective of whether the cancer had progressed. ... The PARAMOUNT trial is a clinical trial studying non-small-cell lung carcinoma (NSCLC). The trial was sponsored by Eli Lilly ...
The white blood cell level falls, further weakening the dog. Any or all of these factors can lead to shock and death. Younger ... Survival rate depends on how quickly CPV is diagnosed, the age of the dog, and how aggressive the treatment is. There is no ... A CPV test should be given as early as possible if CPV is suspected in order to begin early treatment and increase survival ... Myofibers are the site of viral replication within cells. The disease may or may not be accompanied with the signs and symptoms ...
Soto-Gamez A, Quax WJ, Demaria M (2019). "Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions ... Natural killer cells (NK cells) and macrophages play a major role in clearance of senescent cells. Natural killer cells ... Immune system cells can be recruited by SASP to senescent cells, after which the SASP from the senescent cells can induce the ... T cells, B cells, and NK cells have all been reported to become senescent themselves. Senescent-like aging CD8+ cytotoxic T- ...
In any design the driver's feet must not extend beyond the front wheel axle, static crash test of survival cell and fuel cell ... Larger cockpit entry template and survival cell. Rear wings must have no more than 3 elements. 2002 Team orders banned mid- ... 1992 Yet more exhaustive testing of survival cell including rear impact testing, height of kerbing lowered, minimum width of ... survival cell extending to the front of the driver's feet introduced to improve driver survivability in the event of an ...
doi:10.1038/d41586-017-08964-1. Raff, Martin C. (October 1993). "Programmed Cell Death and the Control of Cell Survival: ... His lab also discovered and developed methods for the purification and culturing of retinal ganglion cells and the glial cells ... understand the cell-to-cell interactions in the developmental regulation of nodes of Ranvier and myelin sheaths; 2) determine ... Cell. 180 (3): 502-520.e19. doi:10.1016/j.cell.2019.12.024. PMC 7259679. PMID 31983537. Barres, Ben (2018). Critical Role of ...
They are also nerve cell survival factors. The BMPs bind to the bone morphogenetic protein receptor type-2 (BMPR2). They are ... cell differentiation, cell migration, apoptosis, cellular homeostasis and other cellular functions. The TGFB signaling pathways ... Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2002). Molecular Biology of the Cell. New York, NY: Garland Science ... They are also involved in G1 arrest in the cell cycle. Activin causes the transcription of mRNAs involved in gonadal growth, ...
O'Connor DS, Wall NR, Porter AC, Altieri DC (July 2002). "A p34(cdc2) survival checkpoint in cancer". Cancer Cell. 2 (1): 43-54 ... Hyperplasia (uncontrolled cell growth) is one of the hallmarks of cancer. Because cyclin B is necessary for cells to enter ... On the other hand, if cyclin B levels are depleted the cyclin B/CDK1 complex cannot form, cells cannot enter M phase and cell ... Ford HL, Pardee AB (1999). "Cancer and the cell cycle". J. Cell. Biochem. Suppl 32-33 (S32): 166-72. doi:10.1002/(SICI)1097- ...
ISBN 978-3-318-02347-3. "Cell Survival and Cell Death, Second Edition". Retrieved 2021-06-22. Ruefli-Brasse ... trigger inflammation and cell death. Dixit switched research tracks and began investigating cell death mechanisms. The research ... In 1994 his interests shifted and he began to reorient his research to cell death. In 1997, Dixit became the Director of ... At Genentech, Dixit formed a team with the goal of unraveling the complex interplay between cell death and inflammation at the ...
5 year survival is now around 75%. Large-cell type may have somewhat better prognosis. Surgery is generally not performed ... "Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell ... 5-year survival for invasive thymoma is between 12 and 54% regardless of any myasthenia gravis symptoms.[citation needed] ... Kuo TT (2001). "Classification of thymic epithelial neoplasms: a controversial issue coming to an end?". J. Cell. Mol. Med. 5 ( ...
... kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells". Cancer Res ... Davies AM (1998). "Neuronal survival: early dependence on Schwann cells". Curr. Biol. 8 (1): R15-8. doi:10.1016/s0960-9822(98) ... amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells". Clin. Cancer Res. ... Cell. Biol. 16 (10): 5276-87. doi:10.1128/MCB.16.10.5276. PMC 231527. PMID 8816440. Citri A, Skaria KB, Yarden Y (2003). "The ...
Survival is 96% to 100% at ten years. T-cell prolymphocytic leukemia (T-PLL) is a very rare and aggressive leukemia affecting ... One such approach used genetically modified T cells, known as chimeric antigen receptor T cells (CAR-T cells), to attack cancer ... Large granular lymphocytic leukemia may involve either T-cells or NK cells; like hairy cell leukemia, which involves solely B ... The five-year survival rate is 85%. It is incurable, but there are many effective treatments. One subtype is B-cell ...
with F. P. Muldowney and M. M. Bluhm: Muldowney, F. P.; Bluhm, M. M.; Wayne, E. J. (30 November 1957). "Red-cell Survival in ...
... els do have a reproductive function, but in the wild they also are important as a survival strategy. In most places where ... Internally, a typical corm mostly consists of parenchyma cells, rich in starch, above a circular basal node from which roots ...
"Survival International. Archived from the original on 28 November 2009. Retrieved 19 December 2009.. ... "UNEP and Daimler Call for Infrastructure for Electric and Fuel-cell Vehicles". 4 July 2008. Archived from the ... Indigenous rights organization Survival International has raised concerns that some measures to mitigate the problem of climate ... Stephen Corry, director of Survival International, explains that "projects that victimise the people and harm the environment ...
These are found in all cell membranes and the membranes of most cell organelles.[2] Phosphatidylcholines are structurally ... "Choline intake and risk of lethal prostate cancer: incidence and survival". The American Journal of Clinical Nutrition. 96 (4 ... Choline is stored in the cell membranes and organelles as phospholipids, and inside cells as phosphatidylcholines and ... Acetylcholine is even present in the placenta and may help control cell proliferation and differentiation (increases in cell ...
Many neuronal cells are unresponsive to stimulation by IL-6 alone, but differentiation and survival of neuronal cells can be ... It supports the growth of B cells and is antagonistic to regulatory T cells. ... production of breast cancer stem cell-like cells,[68] metastasis through down-regulation of E-cadherin,[69] and alteration of ... "Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells". Nature ...
"Life-like cells are made of metal". New Scientist. September 14, 2011. Retrieved 2014-05-25.. ... to the problems of survival on other planets.[17] He considered that there was only a remote possibility that non-carbon life ... A hypothetical cell membrane termed an azotosome, capable of functioning in liquid methane in Titan conditions was computer- ... The Cronin group at Glasgow University reported self-assembly of tungsten polyoxometalates into cell-like spheres.[27] By ...
"The first season of SpongeBob was done the old-fashioned way on cells, and every cell had to be part-painted, left to dry, ... "Survival of the Idiots". Larry Leichliter. Written by : Aaron Springer, C.H. Greenblatt, and Merriwether Williams. Storyboarded ...
Hot foam causes the cell walls to rupture, killing the plant. Weed burners heat up soil quickly and destroy superficial parts ... increasing plants survival. Hoegrass was mostly replaced by a group of herbicides that block acetolactate synthase, again ...
In March 2015, China South Rail Corporation (CSR) demonstrated the world's first hydrogen fuel cell vehicle tramcar at an ... Performance in steep terrain partially explains the survival of cable cars in San Francisco. ...
Torres, David L. "Professionalism, Variation, and Organizational Survival." American Sociological Review, Vol. 53, No. 3 (Jun ... Cell death. *Necrosis *Avascular necrosis. *Coagulative necrosis. *Liquefactive necrosis. *Gangrenous necrosis. *Caseous ...
A cholecystectomy is controversial in advanced cancer due to the low 5-year survival rate, especially if regional lymph nodes ... Additionally, in acute cases, a leukocytosis, an increase in white blood cell count, is found. In chronic cases, a ...
... and to spread from cell to cell, causing cell fusion and the formation of multinucleated giant cells.[51] It possesses a ... "Survival of Burkholderia pseudomallei in distilled water for 16 years". Trans R Soc Trop Med Hyg. 105 (10-2): 598-600. doi ... 2000). "Burkholderia pseudomallei induces cell fusion and actin-associated membrane protrusion: a possible mechanism for cell- ... Burkholderia pseudomallei is able to invade cells (it is an intracellular pathogen).[50] It is able to polymerise actin, ...
Polymorphism is one good way the opportunities[vague] get to be used; it has survival value, and the selection of modifier ... from the point of view of survival and reproduction) depends on what other members of the population are doing at the time.[7] ...
Cell》 89: 263-73. PMID 9108481. 2009년 3월 31일에 확인함.. CS1 관리 - 여러 이름 (링크) ... Lévy, J. A. (1993). "HIV pathogenesis and long-term survival". 》AIDS》 7 (11): 1401-10. doi:10.1097/00002030-199311000-00001. ... Clapham PR, McKnight A. (2001). "HIV-1 receptors and cell tropism". 》Br Med Bull.》 58 (4): 43-59. doi:10.1093/bmb/58.1.43. PMID ... Garcia JV, Miller AD (1991년 4월). "Serine phosphorylation-independent downregulation of cell-surface CD4 by nef". 》Nature》 350 ( ...
... the alcohol in hand sanitizers may not have the 10-15 seconds exposure time required to denature proteins and lyse cells.[4] In ... activity is defined as the prolonged or extended antimicrobial activity that prevents or inhibits the proliferation or survival ...
For uses in the natural sciences, see Cell culture and Tissue culture. For other uses, see Culture (disambiguation). ... as humans create the conditions for physical survival, and that the basis of culture is found in evolved biological ...
Gamma delta T cellsEdit. Main article: Gamma delta T cell. Gamma delta T cells (γδ T cells) possess an alternative T cell ... These observations raise questions about mechanisms that favor the survival of most children in Africa while allowing some to ... When B cells and T cells are activated some become memory B cells and some memory T cells. Throughout the lifetime of an animal ... The cells that carry out the adaptive immune response are white blood cells known as lymphocytes. B cells and T cells, two ...
197-216: Ross, Anne "Material Culture, Myth and Folk Memory" (on modern survivals); pp. 217-242: Danaher, Kevin "Irish Folk ... Cell Biology, vol 51 (3), pp. 200-204. ...
74,0 74,1 «Small-cell carcinoma of the prostate»։ Journal of the Royal Society of Medicine 90 (6): 340-1։ June 1997։ PMC ... and survival rates»։ J Natl Cancer Inst 91 (12): 1017-24։ հունիսի 16, 1999։ PMID 10379964։ doi:10.1093/jnci/91.12.1017 , ... 75,0 75,1 «[Clinicopathological characterization of prostatic small cell carcinoma: a case report and review of the literature ... Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel ...
Stephen H. Schneider, Lynne E. Mesirow (1976), The Genesis Strategy: Climate and Global Survival, Plenum Pub Corp; april 1976. ... Schneider overlevde en aggressiv form for kreft, mantle cell lymphoma. Han dokumenterte hans kamp for å erobre tilstanden, ...
In September 2007, the discovery of a violent Israeli Neo-Nazi cell (Patrol 35) in Petah Tikva, made up of teenage immigrants ... the concept of maintaining a Jewish state is necessary for the survival of the Jewish people generally and to provide a safe ...
In the image the back of the chair nearest the viewer is a representation of Nelson Mandela's prison cell on Robben Island, ... in order to assure the survival and success of liberty. ...
"One World: The Health & Survival of the Human Species in the 21st century. Health Press. Retrieved 2007-08-18.. ... "Expansion of the Hadley cell under global warming" (PDF). Geophysical Research Letters. 34: L06805. doi:10.1029/2006GL028443 ...
இவை அந்தந்த உறுப்புகளில் நிலவும் சாதாரண குருத்தணுக்களின் (normal stem cells, ex. neuronal stem cells) சமிக்ஞை தடவழிகளில் (cell ... "in Ries LAG, Smith MA, Gurney JG, Linet M, Tamra T, Young JL, Bunin GR (eds). Cancer Incidence and Survival among Children and ... "Hallmarks of cancer: the next generation". Cell 144 (5): 646-74. March 2011. doi:10.1016/j.cell.2011.02.013. பப்மெட்:21376230. ... doi:10.1016/j.cell.2006.05.051. பப்மெட்:16901782. *↑ Croce CM (January 2008). "Oncogenes and cancer". The New England journal ...
See also: Cell phone novel, Visual novel, Hypertext fiction, and Interactive fiction ... because of its exotic setting and story of survival in isolation. Crusoe lacks almost all of the elements found in these new ...
"Estradiol acts as a germ cell survival factor in the human testis in vitro". The Journal of Clinical Endocrinology and ... Eukaryotic cells respond to damaged DNA by stimulating or impairing G1, S, or G2 phases of the cell cycle to initiate DNA ... Estradiol is produced by action of aromatase mainly in the Leydig cells of the mammalian testis, but also by some germ cells ... "Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G₂/M checkpoint signaling ...
... which upregulates genes necessary for cell survival in low-oxygen environments,[28] and sterol regulatory element binding ... Groups of TFs function in a coordinated fashion to direct cell division, cell growth, and cell death throughout life; cell ... crosses the cell membrane of the recipient cell, and is bound by the estrogen receptor in the cell's cytoplasm. The estrogen ... help regulate the cell cycle and as such determine how large a cell will get and when it can divide into two daughter cells.[30 ...
Biopsies on the bladder walls of people with IC usually contain mast cells. Mast cells containing histamine packets gather when ... Robert M. Moldwin (1 October 2000). The Interstitial Cystitis Survival Guide: Your Guide to the Latest Treatment Options and ... Evidence from clinical and laboratory studies confirms that mast cells play a central role in IC/BPS possibly due to their ... An antiproliferative factor is secreted by the bladders of people with IC/BPS which inhibits bladder cell proliferation, thus ...
"Developmental Cell. 49 (1): 89-99. doi:10.1016/j.devcel.2019.02.001. PMC 6456415. PMID 30827896.. ... The fight or flight response provided them with the mechanisms to rapidly respond to threats against survival.[32][33] ... "HOW CELLS COMMUNICATE DURING THE FIGHT OR FLIGHT RESPONSE". University of Utah. Archived from the original on 8 August 2013. ... This boost of energy is activated by epinephrine binding to liver cells and the subsequent production of glucose.[16] ...
2,0 2,1 2,2 2,3 Vonshak, A. (ed.). Spirulina platensis (Arthrospira): Physiology, Cell-biology and Biotechnology. Londres: ... "Effects of probiotics and spirulina on survival and growth of juvenile common carp (Cyprinus carpio)" (PDF). The Israeli ... "Effects of a Spirulina platensis-based diet on zebrafish female reproductive performance and larval survival rate" (PDF) ...
The survival rate is 58%, which is an increase in comparison to years 1993-2012, where only 34% victims survived. This increase ... a marker for muscle cell damage.[11] Obviously, this figure does not include the dissipation of energy through the chest wall, ... Automated external defibrillators and prompt CPR have helped increase the survival rate in recent years to 58%. CPR and ... "Increasing survival rate from commotio cordis". Heart Rhythm. 10 (2): 219-223. doi:10.1016/j.hrthm.2012.10.034. ISSN 1556-3871 ...
Cite this: Immunotherapy Combos Up Survival in Renal Cell Carcinoma - Medscape - Jul 01, 2022. ... Overall survival with TKI-immunotherapy combinations was longer compared with TKI monotherapy (not reached vs 2.64 years; P = . ... Progression-free survival of 6.1 months for ipilimumab plus nivolumab was shorter than the 11.2 months reported in the ... Median overall survival was also not reached for first-line immunotherapy combination therapy, but the TKI-immunotherapy ...
A cell survival curve is a curve used in radiobiology. It depicts the relationship between the fraction of cells retaining ... Cell survival fractions are exponential functions with a dose-dependent term in the exponent due to the Poisson statistics ... The linear quadratic model is now most often used to describe the cell survival curve, assuming that there are two mechanisms ... Dose fractionation Dose-response relationship Chronic radiation syndrome "Cell Survival Curves" (PDF). Massachusetts Institute ...
Read about the life expectancy of MCL and the survival rate. ... Mantle cell lymphoma (MCL) is a form of non-Hodgkins lymphoma ... Survival Rate *What is the prognosis and survival rate of mantle cell lymphoma? ... Mantle cell lymphoma (MCL) is a relatively rare type of cancer of the lymphoid cells; it is termed mantle cell lymphoma because ... Mantle cell lymphoma (MCL) is a relatively rare cancer of the lymphoid cells that arise from the outer rim or mantle lymphoid ...
Cell death and control of cell survival in the oligodendrocyte lineage. *. B.A. Barres. B.A. Barres ... A quantitative lifespan study of changes in cell number, cell division and cell death in various regions of the mouse forebrain ... Rat neural antigen-2 (RAN-2): a cell surface antigen on astrocytes, ependymal cells, Muller cells and leptomeninges defined by ... Insulin-like growth factor-1 supports embryonic nerve cell survival.. Biochem. Biophys. Res. Commun. 1990; 172: 54-60. *Scopus ...
... cells from donor mice successfully differentiated into Lin-CD24+ cells, Lin-CD24lo cells, and Lin-CD24+c-Kit+Sca1+ cells ( ... Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations. Stem Cells. 2007;25(9):2257- ... Clonogenic survival assay showed that GDNF treatment did not affect cell survival from radiation treatment (Supplemental Figure ... Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair. Cell Stem Cell. ...
Ca2+ influx into apoptotic cells results in the redistribution of PS to the cell surface where it marks the dying cells for ... Phosphatidylserine Asymmetry and Cell Survival. Tuesday, May 1, 2012. The New York Academy of Sciences ... Apoptotic cells are recognized by phagocytes and neighboring cells, and trigger a profound repertoire of affirmative signaling ... Phosphatidylserine is also exposed on tumor cells that are responding to therapy and on exosomes shed by the tumor cells. ...
Journal front-cover study identifies a novel protein in mice that may support embryo cell survival during its very first days ... Protein supports embryo cell survival under metabolic stress. Journal front-cover study identifies a novel protein in mice that ... Scientists have identified a novel protein in mice that may support embryo cell survival in the very first days of its ... 22/02/2019 - Protein supports embryo cell survival under metabolic stress. *18/02/2019 - Aquaculture genetics consortium set to ...
Similar to other immunotherapy, its basic principle is to remove cancer cells in th… ... Chimeric AntigenReceptor T-Cell Immunotherapy, is the most effective treatment of malignant tumors. ... Survival. In order to successfully eliminate the tumor, the targeted T cells must be able to exist in the body for a long ... Signal, Migration and Survival of CAR T Cells Tags: generation signal acircsignal acircsup ...
... produced better survival and freedom from progression rates than would be expected with a conventional transplant regimen, ... after high-dose chemotherapy/autologous peripheral blood stem cell transplantation for B-cell non-Hodgkins lymphoma (NHL) ... Most patients (25) had diffuse large cell NHL, but 3 had mantle cell lymphoma, 3 had transformation of low-grade lymphoma, and ... Rituximab Post-transplant Improves Survival in B-Cell NHL. .social-ris-container { display: flex; justify-content: space- ...
Using prostate tumor-derived cell lines, we showed here that E2F1 activated the expression of transcription f … ... E2F1 Induces tumor cell survival via nuclear factor-kappaB-dependent induction of EGR1 transcription in prostate cancer cells ... we showed here that E2F1 activated the expression of transcription factor EGR1 for promoting cell survival. E2F1 up-regulated ...
Home / Shop / Sort By Year / 2009 / Handbook of Prostate Cancer Cell Research: Growth, Signalling and Survival. ... Natural Products Action on Prostate Cancer Cell Growth, Signaling and Survival;pp. 1-77. (Jorge A. R. Salvador, Vânia M. ... It occurs when cells of the prostate mutate and begin to multiply out of control. These cells may spread (metastasize) from the ... Prostate Stem Cells and Cell Differentiation;pp. 211-241. (Guadalupe Aparicio Gallego, Silvia Díaz Prado, Moisés Blanco Calvo, ...
Cancer cells in children tend to develop by following four main trajectories - and two of them are linked to relapse of the ... When cancer cells multiply, mutations are formed and thus new types of tumour cells, known as clones, can occur. ... Cancer cells in children tend to develop by following four main trajectories - and two of them are linked to relapse of the ... New clones mutate intensively so that a variety of cell types emerge in a specific part of the tumour at the same time. This ...
Todays Item of the day is the Universal Cell Phone Tripod Mount by Carlus. It is hands down the best mount I have found by a ... Universal Cell Phone Tripod Mount - Item of the Day. The Survival Podcast. Posted on January 15, 2021. by Modern Survival. ... The Survival Wiki. Recent Comments. *. Jay on Instant Accu Slim Sous Vide Precision Cooker - Item of the Day. December 8, 2022 ... Posted in Amazon Reviews Tagged audio-video az, cell phone az, technology az, video audio az permalink ...
Lawyers lick their chops as new study links cell phones to lower brain cancer survival rates. By Tero Kuittinen ... This is an interesting twist to the usual theme of simply trying to find a higher frequency of gliomas among heavy cell phone ... Oncologists Hardell and Carlberg opted to analyze the survival rates of glioma patients after the diagnosis had been made. ... Oddly, the study claims that mobile phones and cordless phones had a similar effect on survival rates. This is an interesting ...
Promising Survival for AML Patients Treated with Stem Cells from Related Half Matched Donor ... Promising Survival for AML Patients Treated with Stem Cells. Promising Survival for AML Patients Treated with Stem Cells from ... Allogeneic Stem Cell Transplant Improves Survival for Patients. Allogeneic Stem Cell Transplant Improves Survival for Pediatric ... Allogeneic Stem Cell Transplants Improve Survival Patients with Recurrent CLL. Allogeneic Stem Cell Transplants Improve ...
Search of: Oral Cancer AND Squamous Cell AND cells AND Carcinoma, Squamous Cell AND survival AND Squamous , ( Map: Peru ) - ...
Adding Ibrutinib to Standard of Care Improves Progression Free Survival in Older Patients with Mantle Cell Lymphoma By Kim ... "It is still too soon to say if this regimen will lead to a new standard of care for older patients with mantle cell lymphoma. I ... Mantle cell lymphoma is one of 70 subtypes of non-Hodgkin lymphoma. Relatively rare, it accounts for only 6% of all non-Hodgkin ... "It is still too soon to say if this regimen will lead to a new standard of care for older patients with mantle cell lymphoma. I ...
"Distinct roles of class I PI3K isoforms in multiple myeloma cell survival and dissemination." Blood Cancer Journal 4 (4): e204 ... Distinct roles of class I PI3K isoforms in multiple myeloma cell survival and dissemination. ...
DIRC3 and close to NABP1 Genetics Polymorphisms correlated with Prognostic Survival in Patients with Laryngeal Squamous Cell ... DIRC3 and close to NABP1 Genetics Polymorphisms correlated with Prognostic Survival in Patients with Laryngeal Squamous Cell ... DIRC3 and close to NABP1 Genetics Polymorphisms correlated with Prognostic Survival in Patients with Laryngeal Squamous Cell ... DIRC3 and close to NABP1 Genetics Polymorphisms correlated with Prognostic Survival in Patients with Laryngeal Squamous Cell ...
... ... Predictive factors of survival in patients treated with definitive chemoradiotherapy for squamous cell esophageal carcinoma. ...
503 Studies found for: Oral Cancer AND Squamous Cell AND cells AND Carcinoma, Squamous Cell AND survival AND Squamous ... Oral Cancer AND Squamous Cell AND cells AND Carcinoma, Squamous Cell AND survival AND Squamous (503 records) ... Oral Cancer AND Squamous Cell AND cells AND Carcinoma, Squamous Cell AND survival AND Squamous ... Also searched for Squamous cell carcinoma, Neoplasm, Tumor and more. See Search Details ...
Sana Biotechnology Presents Data at ISSCR 2022 Annual Meeting Showing Survival of Transplanted Hypoimmune iPSC-Derived ... Differentiated Cell Types Without Immunosuppression in Non-Human Primates - read this article along with other careers ... Survival of HIP-modified islet cells for type 1 diabetes. Primary NHP pancreatic islet cells. In this study, allogeneic primary ... Islet cell survival was followed by in vivo bioluminescence imaging. The imaging showed that transplanted cells survived for ...
IDO expression predicts shorter survival of vSCC patients. If immunologic tolerance of the tumor is promoted by the ... is an individual feature and remains stable throughout the course of the disease without impact on the patients survival. ... Expression of indoleamine 2,3-dioxygenase predicts shorter survival in patients with vulvar squamous cell carcinoma (vSCC) not ... High IDO expression was associated with significantly worse overall survival among vSCC patients and was found to be an ...
2022). Cell graph neural networks enable the precise prediction of patient survival in gastric cancer.. NPJ Precis Oncol, 6 (1) ... Cell graph neural networks enable the precise prediction of patient survival in gastric cancer.. ... for the digital staging of TME and precise prediction of patient survival in gastric cancer. In this study, patient survival ... Using Cell-Graphs extracted from mIHC images, CGSignature improves the assessment of the link between the TME spatial patterns ...
Direct B cell-T cell contact regulates naive B cell survival. (A) Purified naive WT B cells were cultured alone or at 1:1 ratio ... SAP-dependent B cell-T cell crosstalk regulates the expression of CD74, SLAMF6, and B cell survival in human cells. (A-D) ... T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell-Cell Contact Mediated through SLAMF6 and SAP. Lihi Radomir, ... To examine whether cell-cell contact or soluble factors are responsible for the T cell-dependent regulation of B cell survival ...
71 Survival in Sickle Cell Disease: Data from a Well-Resourced, National Health System Setting Hemoglobinopathies, Excluding ... For HbSS/HbSβ0, there was a significant difference by hospitalisation rate with survival: median survival in those with ≤0.5 ... Conclusions: These data indicate that adult survival in SCD in our institution is high; estimated median survival of 67 years ... Health economics may play a key role in clinical outcome in SCD; we hypothesise that survival would be longer in a system which ...
The study was conducted using cells from human breast cancers and mouse breast cancer models. ... The study was conducted using cells from human breast cancers and mouse breast cancer models. ... Researchers have come up with a new study exposing significant evidence that tumour cells exposed to low-oxygen conditions have ... Researchers have come up with a new study exposing significant evidence that tumour cells exposed to low-oxygen conditions have ...
The goal of the current study is definitely to assess changes of survival especially malignancy survival by CV risk for ... comorbidity and survival is especially relevant for individuals with renal cell carcinoma [6-8]. While early data on AS for ... the cell migration in human cardiac c-kit+ progenitor cells under physiological conditions ... Goal To assess modification of comparative cancer survival by cardiovascular (CV). * Post author By exposed ...
  • Only the "signal 1″ T cell reaction is incompetent with the reduction of cytokine secretion and proliferation, eventually leading to the apoptosis of T cell. (
  • The bcl-2 oncoprotein has a unique oncogenic role by inhibiting programmed cell death (apoptosis), resulting in tumorigenesis and chemoresistance. (
  • While T3 was essential to T cell survival, it did not significantly affect T cell apoptosis and necrosis rates over 12 days. (
  • While NDRG4 overexpression has no effect on cell viability, NDRG4 knockdown causes G(1) cell cycle arrest followed by apoptosis. (
  • Apoptosis is important in controlling hematopoietic stem cell (HSC) numbers. (
  • Interestingly, the subset of GBM cell lines resistant to IZI1551+marizomib treatments expressed lower surface amounts of TRAIL death receptors, substantially lower amounts of procaspase-8, and increased amounts of cFLIP, suggesting that apoptosis initiation was likely too weak to initiate downstream apoptosis execution. (
  • Indeed, experiments in which the mitochondrial apoptosis threshold was lowered by antagonizing Mcl-1 re-established sensitivity to IZI1551+marizomib in otherwise resistant cells. (
  • The tumor suppressor protein p53 plays a crucial role in coordinating cellular processes, such as cell cycle arrest, apoptosis, and senescence. (
  • In addition, we found that Ninj1 deficiency suppresses cell proliferation but enhances apoptosis and premature senescence in a p53-dependent manner. (
  • Taken together, we provided evidence that Ninj1 is a p53 target and modulates p53 mRNA translation and p53-dependent premature senescence, cell proliferation, apoptosis, and radiationinduced mortality in vitro and in vivo. (
  • Furthermore, ERCC6L silencing induced cell cycle arrest at G0/G1 phase without affecting apoptosis. (
  • We investigated apoptosis and delayed luminescence (DL) of human leukemia Jurkat cells treated with the mitochondrial respiration inhibitor, rotenone (ROT). (
  • ROT decreased clonogenic survival and induced apoptosis in a dose-dependent manner. (
  • Apoptosis evolved slowly, with a maximum effect observed at 48 h, when the apoptotic cell fraction was strongly correlated with clonogenic survival. (
  • AMD3100 enhanced the proliferation of U266 cells induced by interleukin-6 and partially reversed AG490-mediated growth inhibition and apoptosis induced by serum deprivation in RPMI8226 cells. (
  • In contrast, AMD3100 markedly increased the cell apoptosis and reduced the number of RPMI8226 cells after 5 to 7 days of culture under serum-free conditions. (
  • This, in turn, increases the levels of reactive oxygen species and causes apoptosis of tumour cells. (
  • DESCRIPTION (provided by applicant): Altered survival signaling is a hallmark of malignant melanoma cells resulting in resistance to drug-induced apoptosis. (
  • Our preliminary data indicate that heat shock protein 27 (Hsp27) is the exclusive target of MG-adduction in human melanoma and that MG-antagonists selectively induce apoptosis and chemosensitization in human melanoma cells. (
  • Results showed that resveratrol protected against rotenone-induced apoptosis in SH-SY5Y cells and enhanced degradation of α-synucleins in α- synuclein-expressing PC12 cell lines via autophagy induction, suggesting that AMPK-SIRT1-autophagy pathway plays an important role in the neuroprotection by resver atrol on PD cellular models. (
  • Together, these findings strongly suggest that oral administration of probiotics may attenuate cardiomyocyte apoptosis by activation of the phosphatidylinositol‑3 kinase/AKT survival‑signalling pathway in obese rats. (
  • Apoptosis is a known mechanism for the elimination of redundant cells, and it may inhibit cell proliferation. (
  • MSs did not alter cell viability, apoptosis was absent in vitro, and RGCs survived in vitro for seven weeks. (
  • Previously, we demonstrated that protein kinase G type-Iα (PKG-Iα) plays an important role in promoting cell survival in neural cells (N1E-115 neuroblastoma and NG108-15 neuroblastoma-glioma hybrid cells) and significantly contributes to the serine-155 phosphorylation of BAD, an apoptosis-regulating protein [ 1 ]. (
  • Both the kinase-activity inhibition and knockdown of PKG-Iα/β caused significant increases in apoptosis (i.e. decreases in cell survival) and dramatically decreased the cell proliferation, colony formation and cell attachment in both the lung cancer and mesothelioma cells. (
  • Results: MSCs-derived Exo induced apoptosis in human T cells more strongly within 72 hours but not 24 hours of co-culture. (
  • Conclusions: MSCs-derived Exo could induce apoptosis in T cells and lead to immunomodulation by triggering caspase cascade and also down-regulating anti-apoptotic protein levels. (
  • Based on previous studies of the roles of insulin-like growth factor 1 (IGF-1) in neural stem cell isolation in the laboratory, we hypothesized that IGF-1 can enhance proliferation and reduce apoptosis in neural progenitor-like cells (NPCs) during differentiation of MSCs into NCPs. (
  • Cell proliferation and apoptosis were also studied by MTS and Annexin V assay, respectively, at three different time intervals (24 hr, 3 days, and 5 days). (
  • Dysfunction of splicing factors often result in abnormal cell differentiation and apoptosis, especially in neural tissues. (
  • Similarly, GL induces apoptosis in androgeninsensitive prostate cancer cells through activation of ATM/ATR-CHK1 signaling without inducing DNA break. (
  • Thus, GL may perhaps exert antitumoral activity at unique levels: inhibiting the action of your pro-survival transcriptionFigure 7: NAC inhibits GL-induced cell cycle arrest and apoptosis in DU145 cells. (
  • Previous research have shown that GL produces caspase-3 dependent apoptosis in prostate cancer cells [2. (
  • Genetic alterations enhancing cell survival and suppressing apoptosis are hallmarks of cancer that significantly decrease the efficacy of chemotherapy or radiotherapy. (
  • Launch Apoptosis is normally an activity of designed cell death needed for homeostasis maintenance in multicellular microorganisms, which is governed by way of a subset of caspases (Cysteine-dependent ASPartyl-specific proteASES) responsible for propagating, once turned on, the apoptotic indication towards Rabbit Polyclonal to IRF-3 (phospho-Ser385) the nucleus [1]. (
  • U87 glioblastoma cells were highly susceptible to silencing of either SREBP isoform, and apoptosis induced by SREBP1 depletion in these cells was rescued by antioxidants or by restoring the levels of mono-unsaturated fatty acids. (
  • In addition, we found that the rabbit vitreous significantly enhanced cell proliferation (1.5 ± 0.2 fold), survival against apoptosis (2.2 ± 0.2 fold), migration (10 ± 1.5%) and contraction (112.7 ± 14.1 mm) of the cells with dCas9/lacZ-sgRNA compared with those with dCas9/MDM2-sgRNA. (
  • Real-world data confirm phase 3 results showing an overall survival benefit when immunotherapy is added to tyrosine kinase inhibitors as well as for immunotherapy-based combinations to treat metastatic renal cell carcinoma (RCC). (
  • This is a summary of a preprint research study, "Real world data on IO-based therapy for metastatic renal cell carcinoma," led by Viktoria Stühler of University Hospital Tuebingen, Germany, and colleagues. (
  • Cite this: Immunotherapy Combos Up Survival in Renal Cell Carcinoma - Medscape - Jul 01, 2022. (
  • Keywords: little renal mass renal cell carcinoma energetic security comorbidity SEER Medicare Launch Plus a continuous rise in occurrence the administration of little renal public (SRMs) has advanced dramatically within the last several years [1]. (
  • Cardiovascular (CV) comorbidity and survival is especially relevant for individuals with renal cell carcinoma [6-8]. (
  • Purpose: To discover genetic determinants of overall survival (OS) in metastatic renal cell carcinoma (mRCC) patients treated with sorafenib. (
  • Patients with renal cell carcinoma (RCC) who were treated with tivozanib (Fotivda) experienced a 26% reduction in the risk of progression or death compared with sorafenib (Nexavar), according to results from the phase 3 TIVO-3 trial. (
  • The TIVO-3 trial compared the efficacy of tivozanib with sorafenib in 351 patients with renal cell carcinoma who failed at least 2 prior regimens, including VEGFR-TKI therapy. (
  • 1. Lenvatinib plus pembrolizumab was superior to sunitinib in overall survival for patients with advanced renal cell carcinoma. (
  • The standard treatment of advanced renal cell carcinoma (RCC) has been antagonism of vascular endothelial growth factor (VEGF) with tyrosine kinase inhibitors such as sunitinib. (
  • The impact of mononuclear cell infiltration on renal cell carcinoma (RCC) biology has been controversial, previously reported to be associated with either a favorable or unfavorable prognosis. (
  • In this preclinical study, a single-transcriptome analysis revealed a distinct transcriptional signature that was predictive of metastatic potential and patient survival for patients with clear cell renal cell carcinoma (ccRCC). (
  • This is a summary of a preprint research study , "A New Transcriptional Metastatic Signature Predicts Survival in Clear Cell Renal Cell Carcinoma," published July 1 on and led by Peter V. Kharchenko of Harvard Medical School, Boston. (
  • Stage-specific conditional survival in renal cell carcinoma after nephrectomy. (
  • Stage-specific CS has not been widely investigated in the context of renal cell carcinoma (RCC) after nephrectomy. (
  • Comparison of First-Line Anti-PD-1-Based Combination Therapies in Metastatic Renal-Cell Carcinoma: Real-World Experiences from a Retrospective, Multi-Institutional Cohort. (
  • PURPOSE: A renal cell carcinoma (RCC) line, RCC-26, has been identified as a suitable candidate for development of an allogeneic tumor cell vaccine based on its expression of a variety of tumor-associated antigens (TAA). (
  • Long survival of patients with metastatic clear cell renal cell carcinoma. (
  • The treatment landscape in metastatic renal cell carcinoma has changed fundamentally over the last decade by the development of anti-angiogenic agents, mTOR inhibitors, and immunotherapy. (
  • All patients were treated according to their prognostic score (either MSKCC or IMDC) for advanced renal cell carcinoma. (
  • Investigators were also unable to confirm the significant overall survival improvement over TKI monotherapy in Checkmate 214 among intermediate/low-risk patients. (
  • In a subanalysis of 40 patients treated with nivolumab alone starting in the second line, progression-free survival was 5.5 months. (
  • Patients who initially received CD19-targeted T-cell therapy did not have a combined regimen, which made the presence of subsequent T cells in the body almost impossible to detect. (
  • Oncologists Hardell and Carlberg opted to analyze the survival rates of glioma patients after the diagnosis had been made. (
  • The rationale for the study was the 40% to 60% relapse rate among patients receiving high-dose therapy/stem cell transplant, said Steven M. Horwitz, MD, of Stanford University. (
  • Since most B-cell NHL patients express the CD20 antigen, rituximab was considered an excellent candidate for adjuvant therapy in the post-transplant setting. (
  • The study involved 35 patients with B-cell NHL undergoing high-dose therapy/transplant. (
  • Most patients (25) had diffuse large cell NHL, but 3 had mantle cell lymphoma, 3 had transformation of low-grade lymphoma, and 4 had other B-cell lymphomas. (
  • By 12 months, B-cell recovery had not occurred in any of the evaluable patients. (
  • Recent data on patients with SCD in USA confirmed continuing improvement in adult survival, attributed to better preventative care. (
  • In the future, the unique features of the hypoxic cells might be used as biomarkers to identify patients at risk for metastasis, or might be targeted directly by therapies to prevent or limit metastasis, the research team suggested. (
  • The tumour-based hypoxia pattern was also better at predicting the survival of patients free of distant metastases, they concluded after studying similar gene expression data from primary tumours from more than 1000 patients with breast cancer . (
  • Among the next questions to answer, say the researchers, are whether post-hypoxic tumour cells at metastatic sites are more resistant to chemotherapy than other cells and whether targeting these post-hypoxic cells will be beneficial for treating patients with metastatic cancer s. (
  • Goal To assess modification of comparative cancer survival by cardiovascular (CV) risk and treatment strategy among older patients with small renal masses. (
  • High IDO expression was associated with significantly worse overall survival among vSCC patients and was found to be an independent prognostic factor similarly to the tumor grade and patient's age. (
  • IDO expression predicts shorter survival of vSCC patients. (
  • Furthermore, in X-linked lymphoproliferative disease patients, SAP deficiency reduces CD74 expression, resulting in the perturbation of B cell maintenance from the naive stage. (
  • The CD74 receptor induces a similar survival cascade in oncogenically transformed cells derived from chronic lymphocytic leukemia (CLL) patients ( 11 ). (
  • In a population-based study, we determined how urban/rural residence was related to surgery receipt for patients with non-small cell lung cancer. (
  • We assessed the relationship between relative survival and patients' area of residence, taking into account surgery receipt and area socioeconomic level. (
  • Methods We extracted data from the National Cancer Registry Ireland on patients with non-small cell lung cancer diagnosed during 1994-2011 and linked to area-level data on socioeconomic indicators and urban/rural categories. (
  • Conclusions The findings point to the need for targeted policies addressing access to treatment for rural patients with non-small cell lung cancer. (
  • Transcriptome Analysis of Peripheral Blood Mononuclear Cells Response in Patients with Severe COVID-19 Reve. (
  • CHICAGO - When added to the CHOP regimen, alemtuzumab increases remission rates in elderly patients with peripheral T cell lymphoma, final analysis of the international ACT-2 phase 3 trial presented at the American Society of Clinical Oncology (ASCO) 2016 Annual Meeting has shown. (
  • Novel agents for the treatment of elderly patients with peripheral T cell lymphoma remains an urgent medical need," Dr. Trümper concluded. (
  • Alemtuzumab added to CHOP for treatment of peripheral T-cell lymphoma (pTNHL) of the elderly: Final results of 116 patients treated in the international ACT-2 phase III trial. (
  • The median survival of patients with bcl-2-positive tumors was 11 months, as opposed to 13 months for bcl-2-negative tumors. (
  • BACKGROUND: The current study was conducted to determine characteristics distinguishing the 10-year survivor group in patients with systemic immunoglobulin light chain (AL) amyloidosis who underwent autologous stem cell transplantation (SCT). (
  • Survival was significantly lower in patients whose TIL had absent or low ζ expression, controlling for stage ( P = 0.003) and lymph node status ( P = 0.0005). (
  • Clinically, CRC patients with tumors bearing KRas mutations showed better survival if their tumors have low levels of ERH (bottom right), suggesting the mRNA splicing machinery could be exploited for therapeutic benefit. (
  • To explore this hypothesis, the researchers compared patient survival with ERH mRNA levels in two independent groups of CRC patients. (
  • Metastatic non-small cell lung cancer (NSCLC) is highly heterogeneous, and there are patients with limited areas of metastases (oligometastases) or progression (oligoprogression) whose natural history and prognosis can be considerably more favorable. (
  • In ELOQUENT-2 (NCT01239797), elotuzumab plus lenalidomide/dexamethasone (ERd) significantly improved progression-free survival (PFS) versus lenalidomide/dexamethasone (Rd) in patients with RRMM and 1-3 prior lines of therapy (LoTs). (
  • Single-cell RNA sequencing was used to understand the cellular composition and transcriptional status of immune cells - including B cells, myeloid cells, and natural killer cells - between the three patients that died and four who recovered. (
  • We hypothesized that transplacental leukocyte trafficking during pregnancy, which induces long-term, stable, reciprocal microchimerism in mother and child, might influence outcome of patients with acute leukemia given parental donor haploidentical hematopoietic stem cell transplantation (HSCT). (
  • The study determined pembrolizumab plus lenvatinib treated patients had superior progression-free survival and overall survival compared to sunitinib. (
  • The objective of the current study was to evaluate associations between mononuclear cell infiltration in routinely prepared paraffin-embedded specimens with survival in patients with clear-cell RCC. (
  • A total of 306 patients were identified treated with nephrectomy for clear-cell RCC between 1990 and 1994. (
  • For patients with ccRCC, single-cell transcriptomic analysis of tumor cells from the primary tumors revealed a distinct transcriptional signature that can potentially be used to predict metastatic potential and patient survival. (
  • However, research on the association between aspirin use and the survival in patients with lung cancer has revealed inconsistent results. (
  • In this study, we investigated the effect of aspirin use on the survival of inoperable non-small cell lung cancer (NSCLC) patients. (
  • Non-small cell lung cancer (NSCLC) accounts for the majority of all lung cancer cases, and approximately 65% of patients present with locally advanced or metastatic disease at the time of diagnosis [ 3 ]. (
  • A retrospective review by Thomas et al indicated that the use of a single dose of radiation (700-800 cGy) in place of multiple-fraction radiation treatment still results in excellent palliation in patients with cutaneous T-cell lymphoma. (
  • Some patients wish to take a more active role in their cancer treatment by adopting daily lifestyle changes to improve their quality of life or overall survival. (
  • Currently the estimated 5-year overall survival rate is 23.2% for treatment-naive patients and 15.5% for previously treated patients which is significantly better than the historical rate of 5% achieved with chemotherapy. (
  • As a result, patients with lung cancer now typically re-ceive molecular testing that guides their physicians in determining which therapies are more likely to boost the chances of survival while limiting the potential for adverse effects. (
  • The average overall survival duration among Keytruda treated patients is now 26.3 months compared to 14.2 months for those treated with chemotherapy. (
  • To determine whether 2 readily available indicators pre- beyond capacity, which often forced clinicians to make dif- dicted survival among patients with Ebola virus disease in ficult decisions about how to triage patients and how to Sierra Leone, we evaluated information for 216 of the 227 manage patient and family expectations regarding prob- patients in Bo District during a 4-month period. (
  • CHICAGO -- Combining the novel human anti-TIGIT monoclonal antibody tiragolumab with atezolizumab (Tecentriq) plus chemotherapy failed to improve outcomes in patients with untreated extensive-stage small cell lung cancer (SCLC), according the phase III SKYSCRAPER-02 trial presented here. (
  • In the primary analysis, patients who never had brain metastases and were treated with the tiragolumab-based combination had a median progression-free survival (PFS) of 5.4 months compared with 5.6 months in patients who received placebo plus atezolizumab/chemotherapy (HR 1.11, 95% CI 0.89-1.38). (
  • In explaining the rationale behind SKYSCRAPER-02, Rudin noted that while the benefit shown by IMpower133 when adding atezolizumab to a backbone of carboplatin and etoposide "was clearly a clinical advance, the vast majority of patients with extensive-stage small cell lung cancer continue to suffer disease progression, with a median of about five and a half months from the time of diagnosis. (
  • Published early online in CANCER , a peer-reviewed journal of the American Cancer Society, the study indicates that efforts are needed to understand and reduce disparities in the survival of cancer patients from different socioeconomic groups. (
  • However, the researchers found that despite universal healthcare, significant differences in survival across socioeconomic groups persist in Ontario: overall and cancer-specific survival of patients from poorer communities was lower than that of patients residing in more affluent neighborhoods. (
  • The authors noted that additional work is needed to better understand these factors and to develop strategies to reduce disparities in the survival of patients with cancer. (
  • AMD3100, an antagonist of the CXCR4 chemokine receptor is soon to be used clinically for the peripheral mobilization of hematopoietic stem cells (HSCs) in patients with multiple myeloma. (
  • The effects of AMD3100 on survival and proliferation of two myeloma cell lines (RPMI8226 and U266) as well as CD138+ cells obtained from several patients with multiple myeloma were analyzed by flow cytometry using annexin V and a colorimetric cell proliferation assay (CCK-8 assay). (
  • Preoperative Total Serum Cholesterol and Patients' Survival in Resected Nonsmall Cell Lung Cancer. (
  • A significant association was observed between preoperative hypocholesterolemia and patients' survival. (
  • They reported that preoperative TSC might be an important prognostic factor for overall survival after NSCLC resection using the median value for TSC as the cutoff for dividing patients into low and high TSC groups [6]. (
  • The 5-year survival rate was 38.46% among patients with preoperative hypocholesterolemia and 64.26% among others (P = 0.0289). (
  • Effective treatment with 91 percent survival is available for patients with TTP-HUS. (
  • Purpose: To compare the survival of postresection recurrent vs. newly diagnosed non-small-cell lung cancer (NSCLC) patients treated with radiotherapy or chemoradiotherapy. (
  • The median survival time and 5-year overall survival rates were 19.8 months (95% confidence interval [CI], 13.9-25.7) and 14.8% (95% confidence interval, 5.4-24.2%) vs. 12.2 months (95% CI, 10.8-13.6) and 11.0% (95% CI, 8.5-13.5%) for recurrent vs. newly diagnosed patients, respectively (p = .037). (
  • For Stage I-III patients, no significant difference was observed in the 5-year overall survival (p = .297) or progression-free survival (p = .935) between recurrent and newly diagnosed patients. (
  • Conclusion: Our institutional data have shown that patients with postresection recurrent NSCLC achieved survival comparable to that of newly diagnosed NSCLC patients when they were both treated with radiotherapy or chemoradiotherapy. (
  • Randomized phase III NATCH trial in early-stage non-small cell lung cancer (NSCLC) patients (p) reported no statistically differences in disease-free survival (DFS) or overall survival (OS) with the addition of preoperative or adjuvant chemotherapy to surgery. (
  • Researchers from Johns Hopkins Medicine have discovered that the organization of different types of immune cells within pancreatic tumors is associated with how well patients with pancreatic cancer respond to treatment and how long they survive. (
  • researchers have long been searching for more tools - cells, molecules, or genes - that stratify pancreatic cancer patients by survival. (
  • Then, they developed new computational algorithms to analyze how these cells, in number, location, and shape, varied between patients who survived longer or shorter than the median survival time of 619 days. (
  • The researchers discovered that, among the 22 patients who survived shorter than average (a median of 313 days), immune cells called IL-10+ myelomonocytes tended to be located close to a cluster of granzyme B+ CD8+ T cells (or cytotoxic T lymphocytes). (
  • Among the 23 patients who survived longer than average (a median of 832 days), the same myelomonocytes were more grouped near a different type of T cell, known as PD-1+ CD4+ T cells (or activated helper T cells). (
  • But the researchers hope that additional studies will confirm that the tumor microenvironment's association with survival can provide prognostic information to clinicians and potentially steer patients toward certain treatments or clinical trials. (
  • The team found a similar deficit in nNOS at the muscle-cell membrane in tissue samples from human patients with a wide range of myopathies , suggesting a shared mechanism of fatigue. (
  • 5-year cancer-specific survival rates at time of nephrectomy for stage I, II, III, and IV patients in the population-based cohort were 97.4%, 89.9%, 77.9%, and 26.7%, respectively. (
  • Serum zinc concentration appears to be an important prognostic factor for survival of patients diagnosed with laryngeal cancer. (
  • Opdivo did seem to improve outcomes for patients, with median survival rising from 19.6 months for those taking Afinitor to 25 months among patients taking Opdivo, the researchers reported. (
  • Final overall survival results of a randomized trial comparing bortezomib plus pegylated liposomal doxorubicin with bortezomib alone in patients with relapsed or refractory multiple myeloma. (
  • Median overall survival ( OS ) among treated patients was 46.6 months. (
  • Median overall survival was 25.4 months for both phase 2 treated patients and pooled phase 1 and 2 treated patients. (
  • At data cutoff, median overall survival had not yet been reached in phase 2 patients who achieved a complete response. (
  • Mantle cell lymphoma is highly aggressive following relapse, with many patients progressing following therapy. (
  • Survival rates remain very poor in adult patients with relapsed or refractory acute lymphoblastic leukemia, with median overall survival at less than eight months. (
  • CONCLUSIONS: RCC-26 cells coexpressing CD80 and cytokine transgenes display improved immunogenic characteristics, supporting their use as allogeneic tumor cell vaccines for HLA-A2-matched patients with metastatic RCC. (
  • Patients over the age of 18 who applied to Ankara Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital with the diagnosis of small cell lung cancer and distant organ metastasis between January 2015 and December 2019 were retrospectively analyzed. (
  • The authors of this study found that pancreatic metastasis, single metastasis, tumor diameter, and tumor N stage can be used as independent predictive factors for the survival of SCLC patients. (
  • This study intends to discover distinct metastatic patterns and survival rates in extensive stage SCLC patients based on tumor diameter. (
  • Advanced stage patients older than 18 years of age who applied to Ankara Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital between January 2015 and December 2019, were diagnosed with pathological small cell lung cancer, and presented with distant organ metastases were included in the study. (
  • In this trial 98 patients with middle-late stage non-small-cell lung cancer (NSCLC) were randomly allocated to an experimental group, who received standard Western treatment plus Chinese medicine prescribed according to pattern differentiation, and a control group, who received standard Western treatment alone. (
  • Overall survival was 57 months in patients with good or intermediate prognosis and 19 months in patients with poor prognosis. (
  • Overall survival of patients with good and intermediate prognosis was long, suggesting a benefit from the applied approach. (
  • Basel, June 3, 2021 - Novartis today announced that results of the Phase III VISION study evaluating 177 Lu-PSMA-617, a targeted radioligand therapy, plus best standard of care (SOC) demonstrated significant improvement in overall survival (OS) compared to SOC alone, in patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) 1 . (
  • There is currently no immune checkpoint inhibitor approved as a consolidation option for these patients, estimated to represent as many as 25% of people with unresectable Stage III non-small cell lung cancer in the U.S. (
  • As of the March 2022 data cutoff, the final progression-free survival (PFS) analysis of the Phase 3 GEMSTONE-301 trial showed that sugemalimab continued to demonstrate improvement in PFS compared to placebo as consolidation therapy for patients with locally advanced, unresectable Stage III NSCLC without disease progression after concurrent or sequential chemoradiotherapy. (
  • GEMSTONE-301 ( NCT03728556 ) is a randomized, double-blind, placebo-controlled Phase 3 study designed to evaluate the efficacy and safety of sugemalimab versus placebo as consolidation therapy for patients with locally advanced, unresectable Stage III non-small cell lung cancer (NSCLC) without disease progression after either concurrent or sequential chemoradiotherapy. (
  • The prognosis of head and neck squamous cell carcinoma (HNSCC) patients remains poor. (
  • Thus, we have constructed a 6-gene signature as a new prognostic marker for predicting survival of HNSCC patients. (
  • In addition to longer progression-free survival (PFS), researchers also found that patients treated with Abraxane plus carboplatin had a longer median treatment duration compared with patients taking the other drug regimens. (
  • There is accumulating evidence for the association of NLR with survival of patients with many kinds of cancers. (
  • Patients in the highest tertile of neutrophil counts and those in the lowest tertile of lymphocytes experienced shorter survival than the rest of the population. (
  • Additionally, NLR was lower in patients with human papillomavirus (HPV)-positive tumors compared to HPV-negative tumors and predicted survival in both tumor types. (
  • New study results with adjuvant pembrolizumab show statistically significant improvements in disease-free survival (DFS) among patients with stage IB-IIIA non-small cell lung cancer (NSCLC) regardless of programmed death-ligand 1 (PD-L1) expression, according to a press release from Merck. (
  • Data from KEYNOTE-091 suggest adjuvant Keytruda reduced the risk of disease recurrence or death after surgery in the overall population of patients with stage IB-IIIA non-small cell lung cancer. (
  • By moving Keytruda into earlier stages of non-small cell lung cancer, we may be able to reduce the risk of disease recurrence after surgery for patients with stage IB-IIIA non-small cell lung cancer. (
  • Merck's Keytruda (pembrolizumab) showed statistically significant improvement in disease-free survival versus placebo as adjuvant treatment for patients with stage IB-IIIA non-small cell lung cancer regardless of PD-L1 expression. (
  • Although this study found support for the use adjuvant chemotherapy to improve survival in patients with periampullary cancers, this effect was modest, indicating a need for further improvements and warranting the testing of combination chemotherapies. (
  • Methods: A prospective cohort of consecutive patients with non-small cell lung cancer (NSCLC) who were carefully clinically (all underwent dedicated positron emission tomography scans) and pathologically staged with stage I, II, or III disease underwent homogenous treatment algorithms and were followed up over a period of 7 years. (
  • We compared postrelapse overall survival (OS) after autologous/allogeneic (auto/allo) versus tandem autologous (auto/auto) hematopoietic cell transplantation (HCT) in patients with multiple myeloma (MM). Postrelapse survival of patients receiving an auto/auto or auto/allo HCT for MM and prospectively reported to the Center for International Blood and Marrow Transplant Research between 2000 and 2010 were analyzed. (
  • Based on this study, we believe that pre-treatment of patients with autologous monocyte-derived hepatocyte-like cells (NeoHep cells) by 'own cell donation' may represent an effective tool to markedly reduce morbidity and mortality due to postoperative liver failure. (
  • Despite access to optimal multimodality treatment, patients diagnosed with GBM have a low survival rate. (
  • Some patients are not capable of enrolling in Health Insurance schemes while others also lack fare to and back from the designated Sickle cell clinics. (
  • Klose J, Schmitt A, Pernthaler J, Warschkow R, Büchler M, Schneider M, Lasitschka F, Tarantino I. Still proliferating CD44/Ki67 tumor cells after neoadjuvant radiochemotherapy identify rectal cancer patients with poor survival. (
  • Patients were categorized based on whether they were found to have (CD44/Ki67) or not have (CD44/Ki67) still proliferating tumor cells. (
  • In 37 (17%) of these patients, CD44/Ki67 tumor cells were found. (
  • In multivariable Cox regression analysis, patients with CD44/Ki67 cells had significantly impaired overall (hazard ratio (HR): 3.84, 95% CI: 1.77-8.31, p = 0.001) and relative survival (HR 3.44, 95% CI: 1.46-8.09). (
  • The case- fatality rate for pediatric patients in this outbreak was lower than for adults, but the reasons for this increased survival were unknown. (
  • The relatively large number of pediatric cases in this outbreak enabled closer investigation of factors associated with increased survival of pediatric patients with Ebola virus disease. (
  • In this study, we used a series of multiplex assays to measure the concentrations of 55 serum analytes in specimens from patients from the Gulu outbreak to identify biomarkers that had age-specific associations with survival, hemorrhagic manifestations, or both. (
  • Each year worldwide, as many as 300,000 patients are diagnosed with sickle cell disease (SCD). (
  • There are, however, no firm data on the survival of patients with sickle-cell anaemia on the African continent. (
  • 4 o The survival rate of patients with this syndrome decreases with increasing dose. (
  • Treatment and outcomes of hepatocellular carcinoma in patients with Sickle cell disease: a population-based study in the U.S. (
  • Early results from a clinical trial show that a new drug may extend survival for cancer patients with a specific. (
  • T-cell development in the thymus undergoes the process of differentiation, selective proliferation, and survival from CD4 − CD8 − double negative (DN) stage to CD4 + CD8 + double positive (DP) stage prior to the formation of CD4 + helper and CD8 + cytolytic T cells ready for circulation. (
  • In order to assess T3 activity on proliferation and survival of Jurkat T cells, cell staining and flow cytometry-based techniques were used. (
  • EXPERIMENTAL DESIGN: RCC-26 sublines expressing different transgenes were tested for their capacity to reactivate cytokine secretion and cytotoxicity in autologous tumor-infiltrating lymphocytes, to improve proliferation and survival of tumor-associated T cells present in autologous peripheral blood, and to induce tumor-associated responses in naive allogeneic lymphocytes. (
  • Chen N, Hu Z, Yang Y, Han H, Lei H. Inactive Cas9 blocks vitreous-induced expression of Mdm2 and proliferation and survival of retinal pigment epithelial cells . (
  • The goal of this study is to discover a novel strategy to only block vitreous-induced expression of Mdm2 for preventing vitreous-induced cell proliferation and survival and thus find a potential novel strategy to treat proliferation-related diseases. (
  • HIP-modified pluripotent stem cells can serve as the starting material for the differentiation of specialized cell types to serve as cell-based therapeutics. (
  • This includes insights into the control of early decision-making during T-dependent B cell differentiation, the affinity maturation and plasma cell differentiation of germinal center B cells, and the identification of EBI2 as a key regulator of B cell migration and differentiation. (
  • Multiple transcription factors downstream of pre-TCR signaling are involved in T-cell differentiation and survival. (
  • These transcription factors are involved in the cell cycle, differentiation and chromatin remodelling, as well as immune responses. (
  • We found that in the absence of CB1 receptors, cell proliferation was increased and neuronal differentiation reduced, which could be related to CB1 receptor mediated signaling in Doublecortin (DCX)-expressing intermediate progenitor cells. (
  • We will test this hypothesis using mice with T cells that are deficient in the alternative NFkB pathway to determine whether the alternative pathway is necessary for T cell differentiation to effector cells and survival as long-lived memory cells in the immune response to lymphocytic choriomeningitis virus. (
  • It promotes endothelial cell (EC) survival, migration, and differentiation. (
  • The functional roles of these TFs in Ang-1-induced endothelial cell survival, migration, differentiation, and gene regulation were evaluated by using a loss-of-function approach (transfection with siRNA oligos). (
  • Selective siRNA knockdown of ETS1, ELK1, and ETV4 showed that these TFs are required for Ang-1-induced EC survival and differentiation of cells, while ETS1 and ETV4 are required for Ang-1-induced EC migration. (
  • If you want to know What is small cell lung cancer survival rate, make sure to understand its differentiation first. (
  • EGF/bFGF promotes survival, migration and differentiation into neurons of GFP-labeled rhesus monkey neural stem cells xenografted into the rat brain. (
  • The NPCs derived from IGF-1 treatment also resulted in a better yield after the terminal differentiation into neurons and glial cells than that of the other treated groups. (
  • Here, we showed that the differentiation and viability of retinal progenitor cells (RPCs) are severely perturbed in prpf31 knockout zebrafish when compared with other tissues at an early embryonic stage. (
  • This is the first time that Prpf31 is demonstrated to be essential for the survival and differentiation of RPCs during retinal neurogenesis by specifically modulating the alternative splicing of genes involved in DNA repair and mitosis. (
  • Proliferation, cell differentiation and cell survival and, thus, play a vital role in tumorigenesis. (
  • TGF-β regulates a variety of different cellular developmental processes including growth, differentiation, proliferation, and cell death. (
  • CAR-T , Chimeric AntigenReceptor T-Cell Immunotherapy, is the most effective treatment of malignant tumors. (
  • In addition to this strategy, finding other methods of migrating T cells to tumor sites is critical to the successful elimination of tumors. (
  • Exclusions included lacking Medicare A and/or B protection enrollment in handled care plans during treatment regional disease (T3-4 N0M0 TxN1-2M0) distant metastases (TxNxM1) unfamiliar stage upper tract transitional cell carcinoma or ureteric non-cortical renal tumors multiple Procyanidin B2 methods and/or bilateral tumors. (
  • Semiquantitative analysis of the staining intensity for ζ chain expression and number of ζ chain expression-positive cells distinguished tumors with absent or low ζ expression (42 of 132) from those with normal ζ expression (90 of 132). (
  • These results suggest that KRas mutant cells depend on ERH expression because of the complex gene network it controls, and the level of ERH in KRas mutant tumors may reflect their aggressiveness. (
  • In recent years, it has been understood that conventional GBM cell cultures that have traditionally been used to study drug responsiveness, associated signaling, and cell death outcomes poorly reflect the transcriptome characteristics of the original tumors. (
  • The ccRCC cells are highly vascularized tumors with disorganized vasculature, endothelial cells, and pericytes. (
  • The stromal cells within RCC tumors show the highest transcriptional difference of analyzed cell types in comparison to adjacent normal kidney. (
  • CD133, a cell surface antigen, has been shown to be present on cancer stem cells of many solid tumors, including breast cancer. (
  • In recent years, scientists studying many types of cancer have discovered the importance of the noncancerous cells, molecules, and blood vessels surrounding tumors - called the tumor microenvironment. (
  • With the computational approaches we developed, we analyzed not only the density of each cell type but how they interact with each other in the spatial architecture of the tumors," says Mi, the first author of the new paper. (
  • The study met its primary endpoint, demonstrating statistically significant and clinically meaningful improvement in progression-free survival (PFS) compared to placebo as assessed by blinded independent central review according to Response Evaluation Criteria in Solid Tumors version 1.1. (
  • A new study has reported a cost-effective, more accurate, and less invasive way to diagnose cancerous melanoma cells in skin tumors. (
  • Now, research from the Weizmann Institute of Science shows that in melanoma, tumors with cells that have differentiated into more diverse subtypes are less likely to be affected by the immune system, thus reducing the chance that immunotherapy will be effective. (
  • Although the contribution of dysregulated Akt/mTORC1 signaling to cancer has been investigated extensively and altered lipid metabolism is observed in many tumors, the exact role of SREBPs in the control of biosynthetic processes required for Akt-dependent cell growth and their contribution to tumorigenesis remains unclear. (
  • Most of the malignant tumors were squamous cell carcinomas. (
  • Progression-free survival was significantly improved with TKI- immunotherapy combinations compared with both TKI monotherapy (23.9 vs 10.3 months) and immunotherapy combinations (23.9 vs 6.1 months). (
  • H&E, gamma synuclein staining and CTB tracing showed that the survival rate of RGCs in hydrogen saline-treated group was significantly higher than that in saline-treated group. (
  • For HbSS/HbSβ 0 , there was a significant difference by hospitalisation rate with survival: median survival in those with ≤0.5 admissions/year was 67 years, significantly higher than 60 years (CI: 43-77) for high admission rates (p=0.001), see figure 2. (
  • Using Cox's proportional hazards model, median survival in SCLC was determined to be independent of age at diagnosis, stage at presentation, therapeutic modality, and bcl-2 expression, bcl-2 expression does not significantly influence survival in SCLC. (
  • Adding T3 10 µg/mL significantly increased T cell proliferation over 12 days. (
  • Massive cell death occurs during transplantation as well as following engraftment which significantly lowers the effectiveness of the heart cell therapy. (
  • Tendon fibroblasts were significantly more resistant to hyperthermia than NRK 49F cells after 30, 45 and 60 min of heating and significantly more resistant than dermal fibroblasts after 45 and 60 min of heating. (
  • In this study, we found that ERCC6L silencing by small interring RNA (siRNA) or short hairpin RNA (shRNA) significantly inhibited the proliferation of breast (MCF-7, MDA-MB-231) and kidney cancer cells (786-0). (
  • In addition, higher ERCC6L expression was found to be significantly associated with worse clinical survival in breast and kidney cancers. (
  • Histopathology was performed to evaluate corneal graft inflammation.ResultsThe iMDSCs and tMDSCs significantly inhibited T cell proliferation in vitro and significantly prolonged corneal allograft survival in vivo. (
  • The results showed that there was no difference between the two groups at one and three months, but at six months and one year the survival rates of the experimental group was significantly better than the control group. (
  • High-risk MDS cases had a significantly higher percentage of apoptotic CD34+ cells and anti-apoptotic survivin+ cells than controls, particularly for trisomy 8 cases. (
  • RESULTS: Transplantation of both rat hepatocytes and NeoHep cells significantly improved animal survival when compared to control animals (group A: 21%), reaching 72% in group D (p=.001), 50% in group C (p=.04), and 36% in group B (p=.22). (
  • ORLANDO-Giving rituximab (Rituxan) after high-dose chemotherapy/autologous peripheral blood stem cell transplantation for B-cell non-Hodgkin's lymphoma (NHL) produced better survival and freedom from progression rates than would be expected with a conventional transplant regimen, according to a phase II study reported at the 43rd Annual Meeting of the American Society of Hematology (abstract 3578). (
  • abstract = "Bcl-2 overexpression is a common event in small cell carcinomas (SCLC). (
  • abstract = "Close homologue of L1 (CHL1) is a transmembrane cell adhesion molecule that is critical for brain development and for the maintenance of neural circuits in adults. (
  • abstract = "T-cell acute lymphoblastic leukaemia (T-ALL) is a cancer of the immune system. (
  • ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (
  • Kaplan Meier analysis showed an estimated median survival of 77 years (95% CI: 68-85) for all sickle genotypes. (
  • estimated median survival of 67 years for HbSS/Sβ 0 and 82 years for HbSC. (
  • There was no significant difference in median survival between bcl-2-positive and bcl-2-negative SCLC (log rank test, P = .2256). (
  • In the United States of America median survival was estimated in 1994 to be 42 years for men and 48 years for women, whereas comparable figures for Jamaica published in 2001 suggested 53 years for men and 58.5 years for women. (
  • the median survival time from the first episode is only 1-4 months (2-11). (
  • Moreover, the CD28 in CAR can also help transformed T cells to counteract the adverse effects of tumor cell microenvironment. (
  • In addition, CD244, an NK cell receptor, is used to increase the memory effect on tumor cell lysis and the CAR-mediated lethal effect. (
  • Case-control study on survival factors for worldwide hepatocellular carcinoma and ancestry of its tumor cell lines. (
  • Tumor cells are transcriptionally similar to a subset of proximal tubule cells, which may be an indication of the tumor cell of origin. (
  • Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion. (
  • in addition, it showed great cytotoxicity properties against a chosen breast tumor cell range. (
  • Although CAR-T migration has been experimentally verified, it still remains unclear whether T cell genetic modification and in vitro amplification will affect necessary chemokines or cytokines for migration. (
  • To investigate possible pro-tumor properties of 27HC, its effects were studied in vitro in differentiated CaCo-2 cells. (
  • We recently found that short telomeres impair the ability of epidermal stem cells to mobilize out of the hair follicle (HF) niche, resulting in impaired skin and hair growth and in the suppression of epidermal stem cell proliferative capacity in vitro. (
  • Cellular preconditioning and reprogramming by physical, chemical, genetic, and pharmacological manipulation of the cells has shown promise and "prime" the cells to the "state of readiness" to withstand the rigors of lethal ischemia in vitro as well as posttransplantation. (
  • Tendon fibroblasts cultured from the core of the equine SDFT were subjected to a temperature of 45 degrees C in an in vitro system for 0-180 min, and cell survival fraction was measured and compared with that for equine dermal fibroblasts and a commercial rat kidney fibroblast cell line (NRK 49F). (
  • Thus, we explored whether AMD3100 affected the survival and proliferation of myeloma cells in vitro . (
  • AMD3100 exerts dual effects, initially enhancing and subsequently inhibiting the survival and proliferation of myeloma cells, signaling via CXCR4 in vitro . (
  • SDF-1 alone has minimal or negligible effects on the survival and growth of myeloma cells in vitro ( 4 ), but many reports are consistent with the SDF-1/CXCR4 axis being involved in the progression of myeloma. (
  • Their goal is to compare, in vitro , the efficiency of minibeam radiotherapy (MBRT) and standard radiotherapy in inducing clonogenic cell death in glioma cell lines. (
  • The inhibitory abilities of myeloid cells toward CD4(+) T cell proliferation were accessed by in vitro carboxyfluorescein diacetate, succinimidyl ester (CFSE) assays. (
  • A human spinal cord cell promotes motoneuron survival and maturation in vitro. (
  • The safety of MS intravitreal injection was assessed using hematoxylin and eosin, neuronal nuclei (NeuN) immunolabeling, and TUNEL assays, and RGC in vitro survival was analyzed. (
  • The present study determines: 1) if PKG-Iα/β can directly phosphorylate c-Src at serine-17 using in vitro conditions, 2) if serine-17-phophorylation of c-Src, in intact cancer cells, is dependent on PKG-Iα/β expression and kinase activity (using pharmacological inhibitors and shRNA gene knockdown), and 3) if the same inhibition/knockdown of PKG-Iα/β alters cell survival, proliferation and attachment. (
  • MSCs are also known as stromal cells and can be readily isolated from bone marrow and expended in vitro. (
  • In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (
  • A small proportion of CD74 is modified by the addition of chondroitin sulfate, and this form of CD74 is expressed on the surface of APCs (including monocytes and B cells) and epithelial cells ( 7 ). (
  • We describe a novel signalling pathway in which epithelial cell disruption can be minimised and thereby restricts epithelial-mesenchymal transgressions. (
  • This involves IGFBP-5 release from apoptotic cells, which increases epithelial cell adhesion on mesenchymal but not epithelial ECM and involves direct interaction of IGFBP-5 with α2β1 integrins. (
  • Pericytes and fibroblasts have been proposed to be the principal cells that respond to Hh ligands, and pharmacological attenuation of Hh signaling has been considered as a possible treatment for fibrosis, but the effect of Hh inhibition on tubular epithelial cells after kidney injury has not been reported. (
  • GDNF/BDNF-MSs) on migration of the human adult retinal pigment epithelial cell-line-19 (ARPE-19) cells, primate choroidal endothelial (RF/6A) cells, and the survival of isolated mouse retinal ganglion cells (RGCs). (
  • Researchers have identified strain HN019 as having excellent probiotic potential based upon its ability to survive the transit through the human gastrointestinal tract, adhere to epithelial cells, and proliferate. (
  • Combined ablation of SREBP1 and SREBP2 by siRNA-mediated gene silencing or chemical inhibition of SREBP activation induced endoplasmic reticulum (ER)-stress and engaged the unfolded protein response (UPR) pathway, specifically under lipoprotein-deplete conditions in human retinal pigment epithelial cells. (
  • Crucially, depletion of all SREBP isoforms in immortalized human epithelial cells blocked the Akt-dependent increase in cell size, indicating that lipid synthesis is required for cell growth. (
  • Here we show that transmembrane 4 L six family member 5 (TM4SF5) in lung epithelial cells induced the alternatively spliced CD44v8-10 variant via an inverse ZEB2/epithelial splicing regulatory proteins (ESRPs) linkage. (
  • Primary mouse alveolar epithelial cells (AECs) revealed type II AECs (AECII), but not type I, to adapt the TM4SF5-mediated characteristics, suggesting TM4SF5-mediated AECII survival following AECI injury during idiopathic pulmonary fibrosis (IPF). (
  • Then an MDM2-sgRNA targeting the second promoter of human MDM2 gene was cloned into this vector for producing lentivirus to infect human retinal pigment epithelial (RPE) cells with, which carry a heterozygous genotype of MDM2. (
  • The aim of the study is to provide a comprehensive assessment of the incidence of epithelial ovarian cancer (EOC) by histological subtypes and compare EOC survival across seven high income countries involved in the ICBP-SurvMark-2 project, (Australia, Canada, Denmark, Ireland, New Zealand, Norway, and the United Kingdom). (
  • We are applying the hypoimmune platform to a number of programs in our pipeline, including SC291, our CD19 targeted allogeneic CAR T therapy for blood cancers, with a goal of an IND this year, and SC451, our islet cell program with a goal of an IND for the treatment of type 1 diabetes in 2023. (
  • In a large number of cancers, KRas is permanently turned on by a variety of mutations and drives the constant growth of these tumor cells. (
  • Bone cancers can be named 'essential growth' got from bone, bone cells and tissues, and spreading to the skeleton because of different destinations and (metastasis) next cancer. (
  • Undeveloped cell cancers containing intervertebral plate and both crossbuing focus lines. (
  • It is presently unknown whether MIR494 , located at 14q32 which is deleted in renal cancers, reduces cell survival in renal cancer cells and if this process is accompanied by changes in the number of lipid droplets. (
  • Small cell lung cancers are usually not resected," he pointed out, adding that diagnostic biopsy samples may be inadequate or necrotic and that insufficient quality and/or quantity of tumor material can make it difficult to study the expression of PD-L1 and other biomarkers. (
  • We propose that measuring the levels of cyclin D3-CDK6 in human cancers might help to identify tumour subsets that undergo cell death and tumour regression upon inhibition of CDK4 and CDK6. (
  • A new study published online in Nature Communicationson November 4, 2019, reports that some melanomas, which are among the deadliest skin cancers, originate in melanocyte stem cells that are located within the hair follicles. (
  • Some deadly skin cancers may originate in the pigment-making stem cells in hair follicles rather than in skin. (
  • Some of the most deadly skin cancers may start in stem cells that lend color to hair, and originate in hair follicles rather than in skin layers, a new study finds. (
  • 9a shown significant strength as an individual agent in reducing the introduction of solid tumours in mice injected subcutaneously using a individual ovarian cancers cell series, and elevated the median success period of mice within a individual ovarian ascites model [14]. (
  • We retrospectively compared outcomes of unrelated donor bone marrow transplant (UBMT) and HLA-haploidentical peripheral blood stem cell transplantation using post-transplant cyclophosphamide (PTCy-haploPBSCT) using the Japanese registry data. (
  • PTCy-haploPBSCT was associated with remarkably low NRM, contributing to survival outcomes that were comparable to 8/8 matched UBMT. (
  • In previous research on pancreatic cancer, researchers tallied up how many immune cells are present in the tumor microenvironment and found no association with patient outcomes, but Popel and Johns Hopkins graduate student Haoyang Mi hypothesized that the physical arrangement of immune cells might be more important than the total number. (
  • B-cell precursor acute lymphoblastic leukemia is the most common form, accounting for approximately 75% of cases, and treatment is typically associated with inferior outcomes compared with other types of acute lymphoblastic leukemia. (
  • There were different survival outcomes by tumor type, although age, poorly differentiated tumor grade, and lymph node involvement were also independent survival factors," the authors write. (
  • Primary outcomes were 5-year survival and response to neoadjuvant therapy. (
  • The presence of still proliferating CD44/Ki67 tumor cells after neoadjuvant radiochemotherapy was associated with impaired oncological long-term outcomes. (
  • Our findings also show that these post-hypoxic cells have six times the probability of forming lung metastases, suggesting that oxygen starvation enhances their metastatic capabilities," says study leader Daniele Gilkes, Ph.D., assistant professor of oncology and researcher in the breast and ovarian cancer program of the Johns Hopkins Kimmel Cancer Center. (
  • Metastatic non-small cell lung cancer (mNSCLC) has historically been thought as a homogeneous entity that is incurable. (
  • The study contributes to the understanding that is required to improve therapies for metastatic ccRCC by determining how tumor cells are interacting with their microenvironment. (
  • There is limited research on the relationship between tumor diameter and distant metastatic patterns in extensive stage small cell lung cancer (ES-SCLC). (
  • Keytruda has become foundational in the treatment of metastatic non-small cell lung cancer, and we continue to advance research to explore its potential to help fight cancer earlier," said Roy Baynes, PhD, senior vice president, head of global clinical development, and chief medical officer at Merck Research Laboratories, in the press release. (
  • BM endothelial cells in multiple myeloma secrete CXC chemokines, including SDF-1, that mediate interactions with myeloma cells ( 7 ). (
  • Multiple myeloma is an incurable haematological cancer associated with the expansion of abnormal plasma cells within the bone marrow and the development of destructive bone disease. (
  • 001). Better survival was the result of both reduced incidence of relapse and transplantation-related mortality. (
  • One individual was subsequently identified as having CD 40 deficiency in the US, and successfully underwent stem cell transplantation [26]. (
  • In several countries inside and outside Europe, benchmarking systems have been established for haematopoietic stem cell transplantation (HSCT), but access is not universal. (
  • BackgroundAdoptively transferring different sources of myeloid-derived suppressor cells (MDSCs) may assist in mice corneal transplant survival.MethodsAllogeneic full thickness corneal transplantation (donor C57BL/6 to recipient Balb/c mice) was performed. (
  • Myeloid cells were adoptively transferred to corneal recipients by retroorbital injection after corneal transplantation. (
  • However, additional adoptive transfer of MDSCs did not further ameliorate corneal survival in these allogeneic corneal transplantation mice.ConclusionsInflammation-induced MDSC transfer could reduce corneal neovascularization and prolong corneal allograft survival. (
  • We tracked the injected MenSCs 28 days' post-transplantation by anti-human mitochondrial antibody in MI site in rat model and demonstrated successfully transferred human mitochondria from MenSCs into the targeted cells. (
  • Moreover, animals in these groups postoperatively experienced less frequently signs of encephalopathy, they also showed an earlier weight increase when compared to group A. CONCLUSION: Hepatocyte transplantation is a practicable and successful treatment option in the case of liver insufficiency since implantation of NeoHep cells or primary rat hepatocytes had an improving effect on survival. (
  • Those are the small cell (SCLC) and the non-small cell (NSCLC) where both of them aren't the same. (
  • The purpose of the study was to determine whether preoperative hypocholesterolemia (below normal range) is a prognostic factor for survival after nonsmall cell lung cancer (NSCLC) resection. (
  • To our knowledge, there is only one previous study that investigated the relationship between preoperative total serum cholesterol (TSC) and length of survival after nonsmall cell lung cancer (NSCLC) resection [6]. (
  • Objectives # 2 and 3 were tested in a non-small cell lung cancer (NSCLC) cell line, NCI-H23, and two mesothelioma cell lines, MSTO-211H and NCI-H2052. (
  • The NSCLC cells (NCI-H23 lung cancer cells) were found to express only the PKG-Iα isoform, whereas both of the mesothelioma cell lines (MSTO-211H and NCI-H2052) express both PKG-Iα and PKG-Iβ. (
  • 2 Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for 85% of all lung cancer diagnoses. (
  • The main subtypes of NSCLC are adenocarcinoma, squamous cell carcinoma and large cell carcinoma. (
  • Results 15 031 people diagnosed with non-small cell lung cancer were included in the analysis. (
  • (A) An 80-year-old man with lung squamous cell carcinoma and a synchronous isolated metastasis at the thoracic spine. (
  • Talking about What is small cell lung cancer survival rate is quite scary. (
  • So, now you know about What is small cell lung cancer survival rate. (
  • From a clinical standpoint, based on these data, our conclusion is that targeting TIGIT in extensive-stage small cell lung cancer does not appear to be therapeutically relevant," Rudin said. (
  • I will point out, however, that the investigation of tiragolumab is ongoing in multiple other disease contexts, including non-small cell lung cancer and esophageal cancer. (
  • The new results further confirm the potential benefit of that triplet combination "as a standard of care for the treatment of newly-diagnosed extensive-stage small cell lung cancer. (
  • Major pathological response after preoperative chemotherapy as a surrogate marker of survival in early-stage non-small cell lung cancer: cohort of. (
  • 4536 - Stemness characterization of tumorspheres from non-small cell lung cancer. (
  • Small cell lung cancer (SCLC) is a malignant disease that spreads quickly. (
  • This study aimed to investigate the relationship between tumor diameter, distant metastasis site, and survival in extensive stage small cell lung cancer. (
  • Small cell lung cancer (SCLC) is a very aggressive cancer that affects about 31,000 people in the USA each year. (
  • In the updated results from GEMSTONE-301, sugemalimab demonstrated a sustained progression-free survival benefit, underscoring its potential as consolidation therapy for people with locally advanced, unresectable Stage III non-small cell lung cancer," said Vince Miller, MD, physician-in-chief at EQRx. (
  • The findings from the phase 3 KEYNOTE-091 trial mark the first positive study for pembrolizumab in adjuvant stage IB-IIIA non-small cell lung cancer. (
  • We are encouraged by these results supporting the potential role of Keytruda in stage IB-IIIA non-small cell lung cancer. (
  • 1 Department of Radiation Oncology, 2 Cancer Institute and Institute for Stem Cell Biology and Regenerative Medicine, 3 Department of Otolaryngology (Head and Neck Surgery), and 4 Department of Pathology, Stanford University School of Medicine, Stanford, California, USA. (
  • All received a purged stem cell product. (
  • He noted that an intergroup randomized trial is under development to further evaluate the possible benefits of adding rituximab to high-dose therapy with stem cell rescue. (
  • The transplanted cells were induced pluripotent stem cell (iPSC)-derived cardiomyocytes, retinal pigment epithelium (RPE) cells, and islet cells, which were engineered to include Sana's hypoimmune gene modifications that enable immune evasion. (
  • Data were presented by Sonja Schrepfer, M.D., Ph.D., Head of Hypoimmune Platform at Sana, during sessions at the International Society for Stem Cell Research (ISSCR) 2022 Annual Meeting taking place from Wednesday, June 15 through Sunday, June 19 in San Francisco. (
  • This suggests a direct impact of telomere length and telomerase activity on stem cell biology. (
  • Here, we demonstrate that telomerase reintroduction in mice with critically short telomeres is sufficient to correct epidermal HF stem cell defects. (
  • We show that, in contrast to NDRG2, NDRG4 expression is elevated in GBM and NDRG4 is required for the viability of primary astrocytes, established GBM cell lines, and both CD133(+) (cancer stem cell (CSC)-enriched) and CD133(-) primary GBM xenograft cells. (
  • Moreover, growth factors including stem cell factor increased transcription of the Mcl-1 gene and required MCL-1 to augment survival of purified bone marrow progenitors. (
  • This study for the first time demonstrates in a syngeneic mouse model of TNBC that targeting CD133, in an MHC-independent manner, is an effective strategy against the cancer stem cell population, leading to tumor abrogation. (
  • CD133 in Breast Cancer Cells: More than a Stem Cell Marker. (
  • Delivery of Anti-miRNA for Triple-Negative Breast Cancer Therapy Using RNA Nanoparticles Targeting Stem Cell Marker CD133. (
  • Is the regulation of sirt1 by mirna-34a the key to mesenchymal stem cell survival? (
  • Recently, it has been exhibited that mesenchymal stem cell (MSC)-derived Exo could regulate immune cells' biological processes. (
  • Mesenchymal stem cell (MSC) therapy provides an encouraging therapeutic modality for treating autoimmune diseases, sepsis as well as transplant surgery [1, 2]. (
  • They convey efficient cargos such as miRNA and mRNA, proteins, and lipids resulting from stem cell to the neighboring cells. (
  • Although mitochondrial transmission from various sources of stem cells like Bone Marrow Mesenchymal Stem Cell (BM-MSCs), induced Pluripotent Stem Cells (iPSCs), and Dental Pulp Derived Mesenchymal Stem Cell (DP-MSCs) has been stated, there is no report about MT from menstrual blood Stromal/Stem Cells (MenSCs). (
  • Described herein is an ex vivo method of promoting the proliferation of a hematopoietic stem cell, via contacting the cell with a polypeptide. (
  • The invention relates to novel polynucleotides and polypeptides encoded by such polynucleotides, and mutants or variants thereof, which correspond to a novel human stem cell growth factor-like protein. (
  • Further disclosed are vectors containing processes for the production of such novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides. (
  • Prethymic progenitor cells originated from bone marrow migrate into the thymus and sequentially differentiate into CD4 − CD8 − (DN), CD4 + CD8 + (DP), and the CD4 + or CD8 + (SP) stage. (
  • In the presence of Notch signaling, early thymic progenitor (ETP)-DN1 cells transit into DN2a stage, initiating the T-cell lineage commitment, which is immediately accompanied by TCRβ gene arrangement. (
  • Whereas the impact of synthetic cannabinoids on the neuronal progenitor cells has been described, there has been lack of information about the action of plant-derived extracts on neurogenesis. (
  • Therefore we here focused on the effects of Δ9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) fed to female C57Bl/6 and Nestin-GFP-reporter mice on proliferation and maturation of neuronal progenitor cells and spatial learning performance. (
  • CB1 affected the stages of adult neurogenesis that involve intermediate highly proliferative progenitor cells and the survival and maturation of new neurons. (
  • It induces the migration and homing of hematopoietic stem cells (HSCs) and progenitor cells (HPCs) through signaling via the G protein-coupled receptor CXCR4 ( 1 ). (
  • Thereapeutic applications are included, such as in the promotion of wound healing, and as a medicine to proliferate or support human hematopoietic stem cells or human hematopoietic progenitor cells. (
  • In co-culture condition with MSC-derived Exo, the survivals of T cells were assessed by flow cytometry. (
  • DU145 cells have been pre-incubated for 1 h with either UCN-01 (1 M) orcaffeine (10 mM) then treated with GL 10 M for 24 h A, D. Representative cell cycle profiles obtained by flow cytometry at 24 h just after the treatment using the indicated compounds. (
  • Mapping the location of certain immune cells associated with a tumor could be a new biomarker to predict patient survival," says Aleksander Popel, Ph.D., professor of biomedical engineering and director of the Systems Biology Laboratory at the Johns Hopkins University School of Medicine and member of the Johns Hopkins Sidney Kimmel Cancer Center. (
  • The drug, Opdivo (nivolumab), outperformed a standard chemotherapy , Afinitor (everolimus), in terms of shrinking tumours and boosting patient survival, the study found. (
  • Investigation of B lymphocyte biology has benefited not only from the targeted modification of genes controlling B cell survival and responsiveness, but also from the manipulation of antigen specificity made possible by targeting endogenous immunoglobulin loci. (
  • These observations raise the possibility that modulation of the SDF-1/CXCR4 axis could influence the biology of myeloma cells and the disease course. (
  • The interplay between a non-lethal autophagic response and apoptotic cell death is still a matter of debate in cancer cell biology. (
  • Decreasing the expression of ERH in two different colorectal cancer (CRC) cell lines caused more KRas mutant cells to die than cells expressing normal (i.e. wild type) KRas. (
  • Isogenic cell lines were created, and direct cell proliferation assays elucidated variant effects on cell proliferation/cytotoxicity, while endothelial branch formation assays assessed variant effects on endothelial tube formation. (
  • rs1885657 and rs58159269 increased luciferase activity in human endothelial (TIME, LPEC) and mRCC (Caki-1) cells, and rs58159269 increased cell proliferation/reduced sorafenib cytotoxicity, and reduced endothelial tube formation in TIME cells. (
  • Stromal cell analysis within the tumor microenvironment demonstrated vascular remodeling within the endothelial cells and fibroblast proliferation associated with poor survival. (
  • Human umbilical vein endothelial cells (HUVECs) were exposed for different time periods to recombinant Ang-1 protein and mRNA levels of ETS1, ELK1, and ETV4 were measured with qPCR and intracellular localization of these transcription factors was assessed with immunofluorescence. (
  • Recently we have perceived that, transepicardial MenSCs administration could improve cardiac function, prevent metaplastic development, and promote survival of cardiomyocytes following MI conceivably by transfer of their mitochondria to preserved cardiomyocytes and endothelial cells. (
  • Further described are polynucleotides comprising nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). (
  • These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). (
  • The research team first verified that ERH protein was required for the viability of cells expressing a KRas mutation. (
  • Control or MIR494 mimic was expressed in these cells following which cell viability (via crystal violet) and apoptotic cell numbers (via Annexin V/PI staining) were assessed. (
  • Nickel decreases the viability of eosinophils through the induction fo programmed cell death. (
  • The costimulation of CD28 can promote the proliferation of T cells, the synthesis and expression of IL-2 and the secretion of anti-apoptotic protein Bcl-xL. (
  • Many studies have shown that compared the 1st generation, the 2nd generation of CAR with the "second signal" remains the same level of antigen specificity with the increment of T cell proliferation, cytokine secretion, anti-apoptotic protein secretion and the delay of cell death. (
  • The working hypothesis of this proposal is that sustained activation of the alternative NFkB pathway in proliferating T cells in response to late costimulatory signals induces and maintains expression of the cytokines, cytokine receptors, and anti-apoptotic proteins that are necessary for responding T cells to function as differentiated effector cells and survive as memory cells. (
  • Lu et al ( 14 ) observed an increase in cardiac mitochondrial-dependent apoptotic activity in obese rats, shown by increased levels of Bad and cytochrome c release in hearts, as well as suppressed expression of the anti-apoptotic factor B-cell lymphoma 2 (Bcl-2). (
  • Our results suggest that although trisomy 8 cells are in a pro-apoptotic state, they are checked by the enhanced expression of anti-apoptotic signals which provide them with their proliferative advantage. (
  • MIR494 Reduces Renal Cancer Cell Survival Coinciding with Increased Li" by Punashi Dutta, Edward Haller et al. (
  • Previous studies suggest that cancer cell survival depends on the modulation of cell death pathways by methylglyoxal (MG), a reactive by-product of glycolysis that acts by posttranslational modification and functional alteration of target proteins involved in cellular survival. (
  • These neglected non-coding sequences in the human genome have been found to express universally essential proteins for cancer cell survival. (
  • Noncanonical open reading frames encode functional proteins essential for cancer cell survival research paper. (
  • Thus AMPK, in addition to its function in ATP homeostasis, has a key function in NADPH maintenance, which is critical for cancer cell survival under energy stress conditions, such as glucose limitations, anchorage-independent growth and solid tumour formation in vivo. (
  • Regulatory chemotherapy can prolong the presence of adoptive T cells through a variety of ways. (
  • Although chemotherapy after surgery has been shown to have a survival benefit for pancreatic cancer, there have been no randomized trials for periampullary adenocarcinomas. (
  • For the primary analysis, in the observation group, the median (midpoint) survival was 35.2 months and in the chemotherapy group 43.1 months. (
  • The unadjusted primary analysis of the primary outcome of survival did not demonstrate a significant benefit for adjuvant chemotherapy. (
  • Multivariate analysis, correcting for prognostic variables, found a statistically significant survival benefit to chemotherapy and specifically for gemcitabine compared with observation, notwithstanding the better safety profile compared with fluorouracil plus folinic acid, but these results should be considered hypothesis generating. (
  • It has been proved for many times that CAR-T cells can migrate to the periphery of the tumor and recent clinical trials provide more evidence for this: GM-CAR-modified T cells are injected into the patient and CAR can migrate to different tissues. (
  • Cell Immunology studies using tumor lymphocytes have found that there is a positive correlation between the persistence of adoptive T cells and clinical efficacy. (
  • Relative survival estimates with follow-up to 31 December 2012 were calculated for all cases and stratified by surgery receipt, adjusting for clinical variables, area socioeconomic level and other sociodemographic characteristics. (
  • Further clinical trials combining standard treatments with lifestyle modifications are necessary to quantify their survival advantages. (
  • The study demonstrated that 177 Lu-PSMA-617 improves disease progression and prolongs survival, which are key measures of clinical benefit in the mCRPC population. (
  • Other factors associated with superior survival were enrollment in a clinical trial for HCT, male sex, and use of novel agents at induction before HCT. (
  • Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (
  • Recent evidence implicates the formation of lipid droplets as a hallmark event during apoptotic cell death response. (
  • IZI1551+marizomib combination treatments synergistically induced apoptotic cell death in the majority of cases, both in 2D, as well as in 3D spheroid cultures. (
  • Prolonged proteasome inhibition induces proteotoxic stress that ultimately results in apoptotic cell death. (
  • Cholesterol oxidation products such as oxysterols are considered critical factors in the atherosclerotic plaque formation since they induce oxidative stress, inflammation and apoptotic cell death. (
  • The control of BAFF-dependent survival signals by the TRAF2 and TRAF3 signalling proteins is discussed as is the potential involvement of these molecules in B-lineage malignancies. (
  • CD74 stimulation by MIF induces a signaling cascade leading to NF-κB activation, as well as transcription of genes that regulate the entry of the stimulated B cells into the S phase, an increase in DNA synthesis, cell division, and augmented expression of antiapoptotic proteins ( 5 , 9 , 10 ). (
  • PD-1 and PD-L1 are proteins that inhibit certain types of immune responses, allowing cancer cells to evade detection and attack by certain immune cells in the body. (
  • The proteins produced from the MYD88 and CXCR4 genes are both involved in signaling within cells. (
  • Mutations in Drosophila calnexin lead to severe defects in rhodopsin (Rh1) expression, whereas other photoreceptor cell proteins are expressed normally. (
  • They are integrin proteins situated on the surface of Exo and participate in cell adhesion. (
  • Cell growth requires the coordinated synthesis of macromolecules including proteins and lipids. (
  • This group of genes code for proteins found on the surfaces of cells that help the immune system recognize foreign substances. (
  • The envelope contains structures (spike proteins) for attaching to human cells during infection. (
  • Similar to other immunotherapy, its basic principle is to remove cancer cells in the use of the patient's own immune cells, but the difference is that this is a cell therapy instead of a drug. (
  • The SLAM family of receptors includes homophilic and heterophilic receptors that modulate the behavior of immune cells ( 13 - 15 ). (
  • The harsh ischemic and cytokine-rich microenvironment in the infarcted myocardium, infiltrated by the inflammatory and immune cells, offers a significant challenge to the transplanted donor stem cells. (
  • SLAMF7 is a cellular glycoprotein that is highly expressed on MM cells, natural killer (NK) cells, and some other immune cells, but has minimal expression on normal tissues 10 . (
  • By blocking the binding of the PD-L1 ligand these drugs restore an immune cells' ability to recognize and fight the colon cancer cells. (
  • The molecules - found in different combinations on the surface of different immune cell types - correspond to the relative locations of subtypes of immune cells. (
  • In light of what is known about the function of each of these immune cells, Mi says, the results make sense. (
  • The experiments mapping the "fate" of the cells in two- and three-dimensional lab-created tissue systems and in live animals specifically showed that cells from primary cancer exposed to low oxygen levels, or hypoxia, have a four times greater probability of becoming viable circulating tumour cells --and likely spreading to distant tissues--than those under normal oxygen conditions. (
  • Transplanting cells or tissues from a donor to a different recipient currently requires intense immunosuppression to prevent rejection of the transplant. (
  • Immunohistology for expression of the CD3ζ and CD3ε chains in TIL was performed in 138 paraffin-embedded primary oral squamous cell carcinoma tissues and 10 nontumor, inflammatory lesions. (
  • Deletion of Mcl-1 in other tissues, including liver, did not impair survival. (
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (
  • Other features of Waldenström macroglobulinemia are due to the accumulation of lymphoplasmacytic cells in different tissues. (
  • The HLA system is genetically encoded in humans by the major histocompatibility complex (MHC), which is found on chromosome 6, and plays a determining role in immunity and in self-recognition in virtually all cells and tissues, with the exception of erythrocytes. (
  • The major cause of this syndrome is depletion of immature parenchymal stem cells in specific tissues. (
  • Survival Trends in Infants Undergoing Allogeneic Hematopoietic Cell Tr" by Suhag H Parikh, Prakash Satwani et al. (
  • Survival Trends in Infants Undergoing Allogeneic Hematopoietic Cell Transplant. (
  • Washington D.C [USA], Nov 7 (ANI): Researchers have come up with a new study exposing significant evidence that tumour cells exposed to low-oxygen conditions have an advantage when it comes to invading and surviving in the bloodstream. (
  • Some tumour cells retain parts of this genetic signature as a "hypoxic memory" even after they have been reoxygenated, the researchers found. (
  • Cancer cells tend to become more aggressive as they adapt to low oxygen levels," says Gilkes, "but we were surprised to find that cells that were exposed to hypoxia in the primary tumour maintained their aggressive features even when they were reoxygenated in the blood. (
  • However, little is known about how tumour cells change in response to low oxygen. (
  • Gilkes says most research teams--including her own--grow and experiment with tumour cells using the same oxygen concentrations as normal air. (
  • Inhibition of cyclin D3-CDK6 in tumour cells reduces flow through the PPP and serine pathways, thereby depleting the antioxidants NADPH and glutathione. (
  • However, the mechanisms by which AMPK promotes metabolic adaptation in tumour cells are not fully understood. (
  • Circulating tumour cells (CTCs) refer to cells found in the peripheral blood, which are derived from the primary or secondary tumour. (
  • Single CTC analysis allows detection of key mutations that may be critical to disease management and helps to address the intercellular differences among tumour cells. (
  • Briefly, normal cells undergo transformation into tumour cells, which are defined by various hallmarks including the ability to sustain proliferative signals, evade growth suppressors, promote replicative immortality, avoid cell death and immune destruction, induce angiogenesis and activate invasion and metastasis [ 2 ]. (
  • This cellular transformation results in uncontrolled proliferation and enables tumour cells to migrate from their primary organ to a distant organ, a process known as metastasis. (
  • Progression-free survival of 6.1 months for ipilimumab plus nivolumab was shorter than the 11.2 months reported in the Checkmate 214 trial, but the reasons are not clear. (
  • To date, standard treatment for peripheral T cell lymphoma remains unsatisfactory, due to high rates of early disease progression. (
  • So far, the investigation in cancer cell lines of the modulation of cancer growth and progression by oxysterols, in particular 27-hydroxycholesterol (27HC), has yielded controversial results. (
  • NDRG4 is required for cell cycle progression and survival in glioblastoma cells. (
  • As a result of these effects on cell cycle progression and survival, NDRG4 knockdown decreases the tumorigenic capacity of established GBM cell lines and GBM CSC-enriched cells that have been implanted intracranially into immunocompromised mice. (
  • Collectively, these data indicate that NDRG4 is required for cell cycle progression and survival, thereby diverging in function from its tumor suppressive family member NDRG2 in astrocytes and GBM cells. (
  • 2. Lenvatinib plus pembrolizumab demonstrated longer progression-free survival compared to sunitinib. (
  • The study helps to elucidate the specific relationship between stromal cells and tumor cells within the tumor microenvironment to advance understanding of carcinogenesis and cancer progression. (
  • The gap between the two drugs shrank, however, when the study focused on what's known as "progression-free survival" time spent with the disease being in check. (
  • In that case, average progression-free survival was 4.6 months for those taking Opdivo, and 4.4 months for those on Afinitor, the study authors said. (
  • Transiently silencing AGR2 in ER-positive breast cancer cell lines inhibited cell growth and cell-cycle progression and induced cell death. (
  • 0.001) 60% risk reduction for radiographic progression-free survival or death (rPFS), compared to the best standard of care only arm (hazard ratio: 0.40 with 99.2% CI: (0.29 0.57)) 1 . (
  • Investigators found that a weekly combination of Abraxane plus carboplatin resulted in longer progression-free survival (7.4 months) compared with weekly regimens of Abraxane plus gemcitabine (5.4 months), or carboplatin plus gemcitabine (6 months), as the first-line treatment, according to a press release from Celgene. (
  • Research from Prof. Claire Edwards' team at the Botnar Research Centre, and published in the Journal of Bone and Mineral Research, identifies a new mechanism by which myeloma cells alter the bone microenvironment to support disease progression. (
  • It was previously shown that macrophage MIF binds to the CD74 extracellular domain, a process that results in the initiation of a signaling pathway in these cells ( 8 ). (
  • Thus, CAIX plays an important role in the growth and survival of tumor cells under normoxia and hypoxia, making it a potential target for cancer therapy, but is not involved in invasion. (
  • After transiently silencing AGR2 or stimulating with recombinant AGR2, modulation of key regulators of growth and survival pathways was assessed with Western blot. (
  • Because of its impact on cell-growth and -survival pathways, E2 signaling has proven to be an efficacious target for ER-positive breast cancer therapy. (
  • Regulation of lipid metabolism by the Akt/mTORC1 signaling axis is required for the growth and survival of cancer cells. (
  • These pathways have complementary roles in B cell survival ( 4 , 5 ). (
  • The small G-protein KRas acts like a molecular switch, turning on and off pro-growth signaling pathways within cells when appropriate. (
  • KRas itself has proved to be a poor drug target so researchers in the laboratory of Ji Luo, Ph.D., in CCR's Medical Oncology Branch decided to look for other pathways that are essential for the growth of cells expressing mutant KRas. (
  • These pathways could present new drug targets, and blocking their activities might selectively affect cells that express mutant KRas. (
  • In particular, there were transcriptional changes in molecular pathways associated with epigenetic changes in this cell type. (
  • The 27-OH-exerted induction of Nrf2 and subsequently of the target genes, HO-1 and NQO-1, was proved to be: (i) dependent upon the activation of ERK and Akt pathways, (ii) directly responsible for the quenching of intracellular oxidative stress and by this way (iii) ultimately responsible for the observed oxysterol-induced pro-survival response. (
  • The scientists noticed that the chromosome defects they observed with loss of ERH were similar to those that occur in cells lacking the expression of CENP-E, a motor protein that moves chromosomes from the cellular spindle poles to the midline. (
  • Given this tissue-specific expression pattern and the established tumor suppressive roles of the NDRG family in regulating cellular proliferation, we investigated the cellular and biochemical functions of NDRG4 in the context of astrocytes and glioblastoma multiforme (GBM) cells. (
  • miRNAs can regulate cellular survival in various cancer cell types. (
  • Activation of the ERK mitogen-activated protein kinase pathway has been implicated in pro-survival and cellular protective mechanisms. (
  • The aim was to identify cellular and cytogenetic markers of prognostic relevance to survival of high-risk MDS cases. (
  • We recently showed that relatively low concentrations of 27-OH generated a strong survival signaling through an early and transient increase of cellular ROS level, that enhanced MEK-ERK/PI3K-Akt phosphorylation, in turn responsible of a sustained quenching of ROS production. (
  • This mechanism is thought to restrict the lifespan of cells to a limited number of divisions, making telomere length a measure of aging at the cellular level. (
  • RNAi-treated cells showed growth delay in dense monolayer culture and a 50% reduction in clonogenic survival under hypoxia. (
  • They show that this minimum dose can vary per cell line: in F98 cells a dose of 19 Gy was needed to obtain similar levels of clonogenic survival, whereas in U87 cells there was still a slightly increased survival with MB compared to BB 19 Gy treatment. (
  • However, at 19 Gy BB, as well as for the complete dose range of MB irradiation, U87 cells did not show a difference in clonogenic survival between IP and DP. (
  • Also searched for Squamous cell carcinoma , Neoplasm , Tumor and more. (
  • The aim of this study was to evaluate the expression of factor forkhead boxP3 (FOXP3), a marker of Tregs, and IDO in vulvar squamous cell carcinoma (vSCC), and to verify their prognostic significance. (
  • Low levels of serum folate were correlated with an increased severity of laryngeal squamous cell carcinoma. (
  • In order to obtain an objective and consistent conclusion, the authors conducted this comprehensive analysis of the association between NLR and survival of oral, pharyngeal, and laryngeal squamous cell carcinomas. (
  • Valeriote exposed the pancreatic cancer cell line to a sample from the green sponge extract. (
  • The lab test revealed that the green sponge extract had anti-cancer activity, or the ability to kill pancreatic cancer cells. (
  • As a result, even in its earliest stage, the five-year survival rate for the most common type of pancreatic cancer is about 14 percent, according to the American Cancer Society . (
  • More studies are needed to verify those hypotheses about how the cells are interacting in the pancreatic tumor microenvironment, the researchers say, as well as determine whether targeting any of the cell types could lead to new immunotherapies for pancreatic cancer. (
  • One of the strategies to promote T cell migration is to transform genes from the expression of cytokine receptors. (
  • This signaling results in an upregulation of the expression of the cytokine migration inhibitory factor in the T cells and augmented expression of its receptor CD74 on the B cell counterparts, consequently enhancing B cell survival. (
  • and 3) CD74 (invariant chain) expressed on B cells, and its cognate ligand, macrophage migration inhibitory factor (MIF), which is secreted by almost all cell types. (
  • Whilst IGFBP-5 enhanced adhesion, it inhibited cell migration although this was not evident using the truncated c-terminal mutant, suggesting that effects of IGFBP-5 on adhesion and migration involve different mechanisms. (
  • The BDNF/GDNF combination increased RPE cell migration, whereas no effect was observed on RF/6A. (
  • Benchside It is apparent that PAI-1 is a multi-functional SERPIN, affecting such diverse physiological and pathophysiological processes as smooth muscle cell growth, migration, survival and pericellular proteolysis activity. (
  • Sickle-cell anaemia is particularly common among people whose ancestors come from sub-Saharan Africa, India, Saudi Arabia and Mediterranean countries, and migration raised the frequency of the gene in the American continent. (
  • The inhibition of TNFα/NF-κB pathway and CD271 silencing restore the BRAFi sensitivity of resistant melanoma cells. (
  • In all cell lines, inhibition of PKG-Iα/β kinase activity using DT-2 or silencing of PKG-Iα/β expression using shRNA dramatically reduced the intracellular phosphorylation of c-Src at serine-17, whereas addition of the PKG activator 8-bromo-cGMP increased c-Src phosphorylation at serine-17. (
  • The mesothelioma cells in this study express both PKG-Iα and PKG-Iβ, and the inhibition of their expression or kinase activity results in dramatic suppression of the phosphorylation of c-Src at serine-17 and the endogenous activation of c-Src as well as the cell survival, proliferation and attachment of these cells. (
  • This interaction induces cell type-specific signals in both cell types, mediated by the SLAM-associated protein (SAP) family of adaptors. (
  • AMD3100 induces the segregation of leukemic cells ( 11 ) and myeloma cells ( 12 ) in the BM microenvironment, which is expected to enhance the chemosensitivity of the cells. (
  • It is shown that a transient expression of glial cell line-derived neurotrophic factor (GDNF) in the murine ventral midbrain (VM) induces transcription of Pitx3 via NF-κB-mediated signaling, and thatpitx3 is in turn required for activating the expression of brain- derived neurotrophic factors (BDNF) on a rostrolateral mdDA neuron subpopulation during embryogenesis. (
  • Under these conditions, NADPH generation by the pentose phosphate pathway is impaired, but AMPK induces alternative routes to maintain NADPH and inhibit cell death. (
  • Several cell types, such as eosinophils and reticular stromal cells, have been reported to contribute to the survival niche of memory PCs. (
  • By intravital microscopy, we provide for the first time evidence that the direct contacts formed between PCs and reticular stromal cells are stable in vivo, and thus the PCs are sessile in their niches. (
  • The majority (∼ 80%) of PCs directly contact reticular stromal cells in a non-random fashion. (
  • The mesenchymal reticular stromal cells in contact with memory PCs are not proliferating. (
  • In contrast, if eosinophils are depleted by irradiation, newly generated eosinophils localize in the vicinity of radiation-resistant PCs and the stromal cells. (
  • Stromal cell-derived factor-1 (SDF-1) is a chemokine constitutively expressed and produced in bone marrow stromal cells (BMSCs). (
  • 3. Correlate vision cell structure and survival with genes associated with increased risk of advanced AMD. (
  • To define the molecules whose expression is modulated by CD74 to regulate CLL cell survival, we previously screened for CD74 target genes. (
  • Scientists in Luo's laboratory discovered that ERH is a new mRNA splicing factor that facilitates the expression of a subset of cell cycle genes and is required for the survival of KRas mutant CRC cells (top). (
  • Using a small interfering RNA screening method to decrease the expression of genes across the genome, one at a time, the researchers identified a number of candidates that appeared to be essential for KRas mutant cell survival. (
  • Using gene expression microarrays, the investigators found that 87 additional genes, many involved in cell cycle regulation and DNA replication or repair, were also regulated by ERH. (
  • It happens when a child receives two sickle cell genes-one from each parent. (
  • Sickle-cell anaemia is a common genetic condition due to a haemoglobin disorder - inheritance of mutant haemoglobin genes from both parents. (
  • About 5% of the world's population carries genes responsible for haemoglobinopathies and each year about 300 000 infants are born with major haemoglobin disorders - in more than 200 000 cases sickle-cell anaemia in Africa. (
  • Although a single abnormal gene may protect against malaria, inheritance of two abnormal genes leads to sickle-cell anaemia and confers no such protection, and malaria is a major cause of ill-health and death in children with sickle-cell anaemia. (
  • While early data on AS for SRMs have shown encouraging results in carefully selected cohorts recent population-based reports comparing individuals who have deferred therapy (DT) to the people undergoing surgery possess raised issues for inferior malignancy survival [9-11]. (
  • No study has specifically assessed the effect of CV risk on comparative survival for individuals who either undergo surgery treatment or defer therapy for SRMs. (
  • Cyclin D3-CDK6, through its ability to link cell cycle and cell metabolism, represents a particularly powerful oncoprotein that affects cancer cells at several levels, and this property can be exploited for anti-cancer therapy. (
  • This information will be beneficial in the long run for improving both cell-based and cell-free therapy for neurodegenerative diseases. (
  • B. DU145 cells were pre-incubated either NAC (1 mM), epigallocatechin (one hundred M) or ambroxol (100 M) followed by GL ten M therapy. (
  • We tested the hypothesis that after optic nerve crush (ONC), retinal ganglion cell (RGC) could be protected by H₂. (
  • In this study, we test the hypothesis that hyperthermia causes tendon cell death and results in tendon central core degeneration. (
  • In this proposal we will test the hypothesis that the glycolytic control of melanoma cell survival is mediated by MG adducted heat shock protein 27 (MG-Hsp27), a novel therapeutic target amenable to small molecule modulation by specific MG-antagonists. (
  • Their hypothesis was that with MBRT, a similar level of clonogenic cell death can be reached compared to standard radiotherapy, when using equal mean radiation doses. (
  • The T cell activation Signal area is still the bone of contention in the CAR T establishment. (
  • Static and dynamic components synergize to form a stable survival niche for bone marrow plasma cells. (
  • Zehentmeier S, Roth K, Cseresnyés Z, Sercan Ö, Horn K, Niesner RA, Chang HD, Radbruch A, Hauser AE (2014) Static and dynamic components synergize to form a stable survival niche for bone marrow plasma cells. (
  • In the bone marrow (BM), memory plasma cells (PCs) survive for long time periods in dedicated microenvironmental survival niches, resting in terms of proliferation. (
  • Waldenström macroglobulinemia is a rare blood cell cancer characterized by an excess of abnormal white blood cells in the bone marrow. (
  • Myeloma cells also express CXCR4 ( 2 ) and respond to SDF-1, resulting in the trafficking and localization of these cells in the bone marrow (BM) microenvironment ( 3 ). (
  • Naive myeloid cells, inflammation-induced MDSCs (iMDSCs), and tumor-induced MDSCs (tMDSCs) were purified from bone marrow of naive, cecal ligation and puncture, or tumor-bearing Balb/c mice, respectively. (
  • In the last couple of decades, bone marrow fat cells (adipocytes) have emerged as having an important role in bone physiology in health and disease. (
  • In contrast, single-drug treatments largely failed to induce noticeable amounts of cell death. (
  • In a cell line that did not induce CAIX under hypoxia, RT112, we found no effect on the ability of cells transfected with CAIX to invade or migrate. (
  • Within this study, our final results demonstrate that GL was able to induce cell cycle arrest at G2/M phase in human prostate cancer cell lines (DU145 and PC3), with related resultsin other cancer cell lines like Jurkat and SK-N-SH (data not shown). (
  • Here we report that CD271 confers resistance to BRAFi in melanoma cells. (
  • CD271 is upregulated in a subset of BRAFi-resistant melanoma cells. (
  • My recent research suggests that a byproduct of sugar energy metabolism called methylglyoxal may represent an Achilles heel of human melanoma cells. (
  • In the present study performed on human melanoma cells, we investigate the role of basal or stimulated autophagy in cisplatin-induced cytotoxicity, as well as the contribution of cisplatin-induced activation of caspases 3/7 and conventional calpains. (
  • On the whole, our results demonstrate that in human melanoma cells autophagy may function as a beneficial stress response, hindered by cisplatin-induced death mechanisms. (
  • A new study published in Cancer Research suggests that high levels of vitamin D may reduce the aggressive nature of melanoma cells and improve survival rates. (
  • Using a small noncoding RNA, microRNA 211, and tools that track the stability and decay of the protein-coding and noncoding RNAs in lab-grown melanoma cells, a team led by a Johns Hopkins Kimmel Cancer Center researcher identified highly unstable RNA molecules in human melanomas, including a novel miR-211 target gene DUSP3. (