Cell Count
Hypertrophy
Cell Division
Cell Cycle
Adipose Tissue
Cardiomegaly
TOR Serine-Threonine Kinases
Cell Biology
Cells, Cultured
Flow Cytometry
Ribosomal Protein S6 Kinases, 70-kDa
Volvocida
Signal Transduction
Mutation
Plant Epidermis
Lipid Mobilization
Polyploidy
Phenotype
Mitosis
Models, Biological
Phytoplankton
Plant Leaves
G1 Phase
Ribosomal Protein S6 Kinases
Saccharomyces cerevisiae
Vestibular Nucleus, Lateral
Protein Kinases
Myocytes, Cardiac
Carlavirus
Osmium
Body Weight
Schizosaccharomyces
Allium
Sirolimus
Plankton
Culture Media
Cell Differentiation
Cyclins
Glucose
Buttocks
Arabidopsis
Microscopy
Cell Cycle Proteins
Adipocytes
Protein-Serine-Threonine Kinases
Insulin
Ribosomal Protein S6
DNA
Potassium Isotopes
Schizosaccharomyces pombe Proteins
Multiprotein Complexes
Phosphorylation
Arabidopsis Proteins
Molecular Sequence Data
Myocardium
Transcription Factors
Methylobacterium extorquens
Gene Expression Regulation, Fungal
Drosophila Proteins
Geniculate Bodies
Aging
Meristem
Proteins
Global Warming
Microscopy, Electron
Cell Nucleus
Photomicrography
Temperature
Uridine Diphosphate Glucose
Mesophyll Cells
Gene Expression Regulation, Plant
Saccharomyces cerevisiae Proteins
Phenylephrine
RNA, Messenger
Epididymis
Rats, Sprague-Dawley
Diatoms
Sodium Isotopes
Apoptosis
Cell Survival
Proto-Oncogene Proteins c-akt
Lipid Metabolism
S Phase
Drosophila
Gene Expression Regulation
Phosphatidylinositol 3-Kinases
Cells
Larva
Obesity
Protein Biosynthesis
Microscopy, Confocal
Atrial Natriuretic Factor
Glycerol
Microscopy, Electron, Scanning
Gene Expression
Drosophila melanogaster
Eukaryota
Erythrocyte Indices
Image Cytometry
Actins
Plants, Genetically Modified
Single-Cell Analysis
G2 Phase
Biomass
Water Movements
Bacteria
Escherichia coli
Proto-Oncogene Proteins c-myc
Plant Roots
Carbon
Sex differences in the effects of early neocortical injury on neuronal size distribution of the medial geniculate nucleus in the rat are mediated by perinatal gonadal steroids. (1/5001)
Freezing injury to the cortical plate of rats induces cerebrocortical microgyria and, in males but not females, a shift toward greater numbers of small neurons in the medial geniculate nucleus (MGN). The purpose of the current study was to examine a hormonal basis for this sex difference. Cross-sectional neuronal areas of the MGN were measured in male rats, untreated female rats and female rats treated perinatally with testosterone propionate, all of which had received either neonatal cortical freezing or sham injury. Both male and androgenized female rats with microgyria had significantly smaller MGN neurons when compared to their sham-operated counterparts, whereas untreated females with microgyria did not. These differences were also reflected in MGN neuronal size distribution: both male and androgenized female rats with microgyria had more small and fewer large neurons in their MGN in comparison to shams, while there was no difference in MGN neuronal size distribution between lesioned and sham females. These findings suggest that perinatal gonadal steroids mediate the sex difference in thalamic response to induction of microgyria in the rat cortex. (+info)Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells. (2/5001)
We have investigated the effects of the truncated trkB receptor isoform T1 (trkB.T1) by transient transfection into mouse N2a neuroblastoma cells. We observed that expression of trkB.T1 leads to a striking change in cell morphology characterized by outgrowth of filopodia and processes. A similar morphological response was also observed in SH-SY5Y human neuroblastoma cells and NIH3T3 fibroblasts transfected with trkB.T1. N2a cells lack endogenous expression of trkB isoforms, but express barely detectable amounts of its ligands, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). The morphological change was ligand-independent, since addition of exogenous BDNF or NT-4 or blockade of endogenous trkB ligands did not influence this response. Filopodia and process outgrowth was significantly suppressed when full-length trkB.TK+ was cotransfected together with trkB.T1 and this inhibitory effect was blocked by tyrosine kinase inhibitor K252a. Transfection of trkB.T1 deletion mutants showed that the morphological response is dependent on the extracellular, but not the intracellular domain of the receptor. Our results suggest a novel ligand-independent role for truncated trkB in the regulation of cellular morphology. (+info)Gender-related differences in myocyte remodeling in progression to heart failure. (3/5001)
Gender-related differences responsible for the better prognosis of females with heart failure have not been clearly established. To address this issue, we investigated potential gender-related differences in myocyte remodeling in spontaneously hypertensive heart failure rats. Echocardiograms and myocyte growth were compared between males and females at compensated (2, 4, and 6 months) and decompensated (18 months in males and 24 months in females) stages of cardiac hypertrophy. Although left ventricular diastolic dimensions did not differ significantly between failing male and female rats, fractional shortening declined significantly only in failing males. Myocyte cross-sectional area did not change after 4 months of age in both genders, which is likely to be responsible for the absence of a change in left ventricular wall thickness during the progression to heart failure. Myocyte volume and cross-sectional area were significantly larger in males than females at 2, 4, and 6 months of age, although there were no significant differences at the failing stage. Reduced adaptive hypertrophic reserve was observed in males, which is likely to contribute to the higher morbidity and mortality of males with chronic heart failure. (+info)Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. (4/5001)
Nigrostriatal dopaminergic neurons undergo sprouting around the margins of a striatal wound. The mechanism of this periwound sprouting has been unclear. In this study, we have examined the role played by the macrophage and microglial response that follows striatal injury. Macrophages and activated microglia quickly accumulate after injury and reach their greatest numbers in the first week. Subsequently, the number of both cell types declines rapidly in the first month and thereafter more slowly. Macrophage numbers eventually cease to decline, and a sizable group of these cells remains at the wound site and forms a long-term, highly activated resident population. This population of macrophages expresses increasing amounts of glial cell line-derived neurotrophic factor mRNA with time. Brain-derived neurotrophic factor mRNA is also expressed in and around the wound site. Production of this factor is by both activated microglia and, to a lesser extent, macrophages. The production of these potent dopaminergic neurotrophic factors occurs in a similar spatial distribution to sprouting dopaminergic fibers. Moreover, dopamine transporter-positive dopaminergic neurites can be seen growing toward and embracing hemosiderin-filled wound macrophages. The dopaminergic sprouting that accompanies striatal injury thus appears to result from neurotrophic factor secretion by activated macrophages and microglia at the wound site. (+info)Interleukin-12 is synthesized by mesangial cells and stimulates platelet-activating factor synthesis, cytoskeletal reorganization, and cell shape change. (5/5001)
Preliminary studies indicate the involvement of interleukin (IL)-12 in experimental renal pathology. In the present study, we evaluated whether cultured glomerular mesangial cells are able to produce IL-12 and whether IL-12 may regulate some of their functions, including the cytoskeletal reorganization, the change in cell shape, and the production of platelet-activating factor (PAF). The results obtained indicate that pro-inflammatory stimuli, such as tumor necrosis factor-alpha and bacterial polysaccharides, induce the expression of IL-12 mRNA and the synthesis of the protein by cultured mesangial cells. Moreover, cultured mesangial cells were shown to bind IL-12 and to express the human low-affinity IL-12 beta1-chain receptor. When challenged with IL-12, mesangial cells produced PAF in a dose- and time-dependent manner and superoxide anions. No production of tumor necrosis factor-alpha and IL-8 was observed. Moreover, we demonstrate that IL-12 induced a delayed and sustained shape change of mesangial cells that reached its maximum between 90 and 120 minutes of incubation. The changes in cell shape occurred concomitantly with cytoskeletal rearrangements and may be consistent with cell contraction. As IL-12-dependent shape change of mesangial cells was concomitant with the synthesis of PAF, which is known to promote mesangial cell contraction, we investigated the role of PAF using two chemically different PAF receptor antagonists. Both antagonists inhibited almost completely the cell shape change induced by IL-12, whereas they were ineffective on angiotensin-II-induced cell shape change. In conclusion, our results suggest that mesangial cells can either produce IL-12 or be stimulated by this cytokine to synthesize PAF and to undergo shape changes compatible with cell contraction. (+info)Neurite outgrowth-regulating properties of GABA and the effect of serum on mouse spinal cord neurons in culture. (6/5001)
Time-lapse photography was used to examine the effects of gamma-aminobutyric acid (GABA) on the outgrowth and motility of neurites in cultures from mouse spinal cord. GABA at concentrations of 100, 10 and 1 microM caused significant inhibition of neurite outgrowth and the motility of growth cones was significantly reduced by treatment with 100 and 10 microM GABA. This effect was mimicked by the GABA(B) receptor agonist baclofen, whereas the GABA(A) receptor agonist muscimol had no effect. The effect of GABA on outgrowth and motility seems to be dependent on the type of serum employed. The results reported here were obtained only when heat-inactivated serum was used and not when non heat-inactivated serum was added to the culture medium. They suggest that GABA has a role in the regulation of process outgrowth within the embryonic mouse spinal cord. (+info)Regulation of p190 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation. (7/5001)
The v-Src oncoprotein perturbs the dynamic regulation of the cellular cytoskeletal and adhesion network by a mechanism that is poorly understood. Here, we have examined in detail the effects of a temperature-dependent v-Src protein on the regulation of p190 RhoGAP, a GTPase activating protein (GAP) that has been implicated in disruption of the organised actin cytoskeleton, and addressed the dependence of v-Src-induced stress fibre loss on inhibition of Rho activity. We found that activation of v-Src induced association of tyrosine phosphorylated p190 with p120(RasGAP) and stimulation of p120(RasGAP)-associated RhoGAP activity, although p120(RasGAP) itself was not a target for phosphorylation by v-Src in chicken embryo cells. These events required the catalytic activity of v-Src and were linked to loss of actin stress fibres during morphological transformation and not mitogenic signalling. Furthermore, these effects were rapidly reversible since switching off v-Src led to dissociation of the p190/p120(RasGAP) complex, inactivation of p120(RasGAP)-associated RhoGAP activity and re-induction of actin stress fibres. In addition, transient transfection of Val14-RhoA, a constitutively active Rho protein that is insensitive to RhoGAPs, suppressed v-Src-induced stress fibre loss and cell transformation. Thus, we show here for the first time that an activated Src kinase requires the inactivation of Rho-mediated actin stress fibre assembly to induce its effects on actin disorganisation. Moreover, our work supports p190 as a strong candidate effector of v-Src-induced cytoskeletal disruption, most likely mediated by antagonism of the cellular function of Rho. (+info)C-PR neuron of Aplysia has differential effects on "Feeding" cerebral interneurons, including myomodulin-positive CBI-12. (8/5001)
Head lifting and other aspects of the appetitive central motive state that precedes consummatory feeding movements in Aplysia is promoted by excitation of the C-PR neuron. Food stimuli activate C-PR as well as a small population of cerebral-buccal interneurons (CBIs). We wished to determine if firing of C-PR produced differential effects on the various CBIs or perhaps affected all the CBIs uniformly as might be expected for a neuron involved in producing a broad undifferentiated arousal state. We found that when C-PR was fired, it produced a wide variety of effects on various CBIs. Firing of C-PR evoked excitatory input to a newly identified CBI (CBI-12) the soma of which is located in the M cluster near the previously identified CBI-2. CBI-12 shares certain properties with CBI-2, including a similar morphology and a capacity to drive rhythmic activity of the buccal-ganglion. Unlike CBI-2, CBI-12 exhibits myomodulin immunoreactivity. Furthermore when C-PR is fired, CBI-12 receives a polysynaptic voltage-dependent slow excitation, whereas, CBI-2 receives relatively little input. C-PR also polysynaptically excites other CBIs including CBI-1 and CBI-8/9 but produces inhibition in CBI-3. In addition, firing of C-PR inhibits plateau potentials in CBI-5/6. The data suggest that activity of C-PR may promote the activity of one subset of cerebral-buccal interneurons, perhaps those involved in ingestive behaviors that occur during the head-up posture. C-PR also inhibits some cerebral-buccal interneurons that may be involved in behaviors in which C-PR activity is not required or may even interfere with other feeding behaviors such as rejection or grazing, that occur with the head down. (+info)There are several types of hypertrophy, including:
1. Muscle hypertrophy: The enlargement of muscle fibers due to increased protein synthesis and cell growth, often seen in individuals who engage in resistance training exercises.
2. Cardiac hypertrophy: The enlargement of the heart due to an increase in cardiac workload, often seen in individuals with high blood pressure or other cardiovascular conditions.
3. Adipose tissue hypertrophy: The excessive growth of fat cells, often seen in individuals who are obese or have insulin resistance.
4. Neurological hypertrophy: The enlargement of neural structures such as brain or spinal cord due to an increase in the number of neurons or glial cells, often seen in individuals with neurodegenerative diseases such as Alzheimer's or Parkinson's.
5. Hepatic hypertrophy: The enlargement of the liver due to an increase in the number of liver cells, often seen in individuals with liver disease or cirrhosis.
6. Renal hypertrophy: The enlargement of the kidneys due to an increase in blood flow and filtration, often seen in individuals with kidney disease or hypertension.
7. Ovarian hypertrophy: The enlargement of the ovaries due to an increase in the number of follicles or hormonal imbalances, often seen in individuals with polycystic ovary syndrome (PCOS).
Hypertrophy can be diagnosed through various medical tests such as imaging studies (e.g., CT scans, MRI), biopsies, and blood tests. Treatment options for hypertrophy depend on the underlying cause and may include medications, lifestyle changes, and surgery.
In conclusion, hypertrophy is a growth or enlargement of cells, tissues, or organs in response to an excessive stimulus. It can occur in various parts of the body, including the brain, liver, kidneys, heart, muscles, and ovaries. Understanding the underlying causes and diagnosis of hypertrophy is crucial for effective treatment and management of related health conditions.
Medical Term: Cardiomegaly
Definition: An abnormal enlargement of the heart.
Symptoms: Difficulty breathing, shortness of breath, fatigue, swelling of legs and feet, chest pain, and palpitations.
Causes: Hypertension, cardiac valve disease, myocardial infarction (heart attack), congenital heart defects, and other conditions that affect the heart muscle or cardiovascular system.
Diagnosis: Physical examination, electrocardiogram (ECG), chest x-ray, echocardiography, and other diagnostic tests as necessary.
Treatment: Medications such as diuretics, vasodilators, and beta blockers, lifestyle changes such as exercise and diet modifications, surgery or other interventions in severe cases.
Note: Cardiomegaly is a serious medical condition that requires prompt diagnosis and treatment to prevent complications such as heart failure and death. If you suspect you or someone else may have cardiomegaly, seek medical attention immediately.
Polyploidy is a condition where an organism has more than two sets of chromosomes, which are the thread-like structures that carry genetic information. It can occur in both plants and animals, although it is relatively rare in most species. In humans, polyploidy is extremely rare and usually occurs as a result of errors during cell division or abnormal fertilization.
In medicine, polyploidy is often used to describe certain types of cancer, such as breast cancer or colon cancer, that have extra sets of chromosomes. This can lead to the development of more aggressive and difficult-to-treat tumors.
However, not all cases of polyploidy are cancerous. Some individuals with Down syndrome, for example, have an extra copy of chromosome 21, which is a non-cancerous form of polyploidy. Additionally, some people may be born with extra copies of certain genes or chromosomal regions due to errors during embryonic development, which can lead to various health problems but are not cancerous.
Overall, the term "polyploidy" in medicine is used to describe any condition where an organism has more than two sets of chromosomes, regardless of whether it is cancerous or non-cancerous.
Body weight is an important health indicator, as it can affect an individual's risk for certain medical conditions, such as obesity, diabetes, and cardiovascular disease. Maintaining a healthy body weight is essential for overall health and well-being, and there are many ways to do so, including a balanced diet, regular exercise, and other lifestyle changes.
There are several ways to measure body weight, including:
1. Scale: This is the most common method of measuring body weight, and it involves standing on a scale that displays the individual's weight in kg or lb.
2. Body fat calipers: These are used to measure body fat percentage by pinching the skin at specific points on the body.
3. Skinfold measurements: This method involves measuring the thickness of the skin folds at specific points on the body to estimate body fat percentage.
4. Bioelectrical impedance analysis (BIA): This is a non-invasive method that uses electrical impulses to measure body fat percentage.
5. Dual-energy X-ray absorptiometry (DXA): This is a more accurate method of measuring body composition, including bone density and body fat percentage.
It's important to note that body weight can fluctuate throughout the day due to factors such as water retention, so it's best to measure body weight at the same time each day for the most accurate results. Additionally, it's important to use a reliable scale or measuring tool to ensure accurate measurements.
There are several different types of obesity, including:
1. Central obesity: This type of obesity is characterized by excess fat around the waistline, which can increase the risk of health problems such as type 2 diabetes and cardiovascular disease.
2. Peripheral obesity: This type of obesity is characterized by excess fat in the hips, thighs, and arms.
3. Visceral obesity: This type of obesity is characterized by excess fat around the internal organs in the abdominal cavity.
4. Mixed obesity: This type of obesity is characterized by both central and peripheral obesity.
Obesity can be caused by a variety of factors, including genetics, lack of physical activity, poor diet, sleep deprivation, and certain medications. Treatment for obesity typically involves a combination of lifestyle changes, such as increased physical activity and a healthy diet, and in some cases, medication or surgery may be necessary to achieve weight loss.
Preventing obesity is important for overall health and well-being, and can be achieved through a variety of strategies, including:
1. Eating a healthy, balanced diet that is low in added sugars, saturated fats, and refined carbohydrates.
2. Engaging in regular physical activity, such as walking, jogging, or swimming.
3. Getting enough sleep each night.
4. Managing stress levels through relaxation techniques, such as meditation or deep breathing.
5. Avoiding excessive alcohol consumption and quitting smoking.
6. Monitoring weight and body mass index (BMI) on a regular basis to identify any changes or potential health risks.
7. Seeking professional help from a healthcare provider or registered dietitian for personalized guidance on weight management and healthy lifestyle choices.
Cell nucleus
Hybrid solar cell
Cell proliferation
Cell biology
Cell growth
24-cell
Small-cell carcinoma
Raphanus raphanistrum
Lipid droplet
Genome diversity and karyotype evolution of mammals
BS National Beehive
CCDC190
Histone acetyltransferase
Cell site
Quantum dot solar cell
Cell sorting
Bistratified cell
Muse cell
Retinal ganglion cell
Red blood cell distribution width
Programmable metallization cell
Red blood cell
List of unsolved problems in biology
Theodor Schwann
Cyclotella
Copurification
Microscopic scale
Enzymatic biofuel cell
Cell (microprocessor)
Cell relay
Camelpox
Sulfide
Atrioventricular node
Technopark, Trivandrum
Synthetic virology
Earmuffs
Hemoencephalography
Phage display
G1 phase
Hutterites
Mie scattering
Zeatin
Edmonson, Texas
NFIX
Epcot
United States border security concerns
Ma'agan Michael Ship
1992 Queensland storms
Proto-oncogene tyrosine-protein kinase Src
Robot research initiative
Cotylorhiza tuberculata
The Variation of Animals and Plants Under Domestication
Joseph Cheesman Thompson
Imperial examination
Scuba set
Janus (time-reversible computing programming language)
Strømme syndrome
Tet (company)
Methylocella silvestris
Solanum arcanum
Decrease of 5-hydroxymethylcytosine in primary cutaneous CD4+ small/medium sized pleomorphic T-cell lymphoproliferative...
Dendritic Cell Cancer Vaccine Market Size & Share Report 2030
Cell size assays for mass cytometry - PubMed
Pseudomonas syringae Responds to the Environment on Leaves by Cell Size Reduction
NiMH Rechargeable Cell: SANYO A size 1.2V 2700 mAh (1PC)
Inquire Before Buying - Graphene Solar Cell Market Size, Share, & Forecast 2030
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Sizing Up Stem Cells - HUM-MOLGEN news
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Argentina Stem Cell Banking Market: Prospects, Trends Analysis, Market Size and Forecasts up to 2028
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Inquiry before buying - Single Cell Oil Market Size & Share | Forecast Report 2023-2032
Flexible Panel Sizing Cells Flexstore ELR + gabbiani g2 - SCM Group
Clearance Gifts & Collectibles - Format: Action Figures or Sleepwear or Film Cells or Bottoms - Shirt Sizes: L | OLDIES.com
Small Cell Market SWOT Analysis by Size 2023 | Opportunities, Challenges, Emerging Trends, Market Dynamics and Forecast to 2027...
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Circulating Tumor Cells Market Size Worth $30.78 Billion By 2029 | CAGR: 14.9%
Genome size, cell size and growth; searching for the causal links - Prosjektbanken
Weekly science reads: CRISPR, stem cells, cell size & space, more - The Niche
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Inhibitory phosphorylation of a mitotic cyclin-dependent kinase regulates the morphogenesis, cell size and virulence of the...
Preparation of nano-sized nickel as anode catalyst for direct urea and urine fuel cells<...
Repair of critical-size defects with autogenous periosteum-derived cells combined with bovine anorganic apatite/collagen: an...
Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats |...
Automated Cell Culture System Market Size, Forecast, and Trend Highlights Over 2023 - 2033
Dehydroxylation of aluminous goethite: Unit cell dimensions, crystal size and surface area<...
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Genome size7
- We here aim both at exploring the causal links between growth rate, genome size and cell size and the evolutionary drivers for reduced genome size. (forskningsradet.no)
- There are likely several routes to genome size variability within and across taxa. (forskningsradet.no)
- Here, we are mainly inte rested in the observation that meiosis and cell division often is negatively correlated with genome size across plant and animal taxa. (forskningsradet.no)
- Since genome size and cell size also are tightly coupled, both cell and genome size should also show a strong negative c orrelation with developmental time. (forskningsradet.no)
- A crucial question is thus the evolutionary drivers for reduced genome size in organisms, and how this actually i s solved by the organisms. (forskningsradet.no)
- The scientific goal of the Heald Lab is to leverage amphibian systems to elucidate molecular mechanisms of cell division and size control, as well as the contribution of genome size and content to organism physiology. (nih.gov)
- We are investigating how mitotic chromosome size scales with cell size, and leveraging ploidy manipulation and a variety of amphibian species to explore relationships among genome size, cell size, embryonic development, and metabolism. (nih.gov)
Embryonic2
- Above image: Confocal microscopy image of human embryonic kidney cells. (jhu.edu)
- Compared with embryonic stems cells and bone marrow-derived mesenchymal stem cells, ADMSCs have the distinct advantages of being abundant, easy to obtain with minimal invasiveness, and readily cultured to a sufficient number for autologous transplantation without ethical issue. (biomedcentral.com)
Regulates1
- The histone methyltransferase SETD2 negatively regulates cell size. (bvsalud.org)
Growth13
- The global dendritic cell cancer vaccine market size was valued at USD 593.30 million in 2022 and is projected to expand at a compound annual growth rate (CAGR) of 12.18% from 2023 to 2030. (grandviewresearch.com)
- The growing demand for effective and personalized therapeutics is positively impacting the growth of the dendritic cell cancer vaccine market. (grandviewresearch.com)
- Immunotherapy has great potential for treating minimal residual disease (MRD) by the use of dendritic cells and many studies have yielded promising results with no signs of recurrence of tumor growth. (grandviewresearch.com)
- Some decrease in cell size occurred during growth of cells on leaves and continued for up to 13 days after cell multiplication ceased. (apsnet.org)
- The Direct Methanol Fuel Cell market industry is projected to grow from USD 2.54 Billion in 2022 to USD 6.88 Billion by 2030, exhibiting a compound annual growth rate (CAGR) of 13.26% during the forecast period (2022 - 2030). (marketresearchfuture.com)
- Research by John Innes Centre scientists reveals how cells use geometrical information to control key developmental processes such as the coordination between cell growth and cell division. (jic.ac.uk)
- Varying container size alters the volume which plant roots can explore, which in turn affect plant growth. (techscience.com)
- This work assesed the effect of the initial container size on growth of Petunia x híbrida cv Dream Mix, supplemented with cytokinins after potting. (techscience.com)
- Final weight and growth rate of potted plants, coming from trays of 288 cells, were smaller than those coming from trays of 90 cells. (techscience.com)
- Cell size employed in early growth stages conditioned size and final quality of petunia plants. (techscience.com)
- 2) What are the factors that affect the growth in the stem cell banking market over the forecast period? (researchandmarkets.com)
- Cell growth, structure, and function more closely mimic what occurs in vivo. (thomassci.com)
- Increasing prevalence of cancer disease, increasing R&D activities of therapies, and increased demand for personalized medicine are driving the circulating tumor cells market growth. (polarismarketresearch.com)
Biology2
- Seminars in Cell & Developmental Biology (2016) 57: 93. (biologists.com)
- Rebecca Health is a professor of Cell and Developmental Biology. (nih.gov)
Morphogenesis1
- This research has provided novel insight into cell division and morphogenesis, processes essential for viability and development, and defective in human diseases such as cancer. (nih.gov)
Particle size2
- Nano-sized nickel with primary particle size of 2-3 nm has been successfully prepared for use as efficient anode catalysts in urea and urine fuel cells. (coventry.ac.uk)
- It is believed that the toxicity and carcinogenesis of TiO2 is associated with particle size. (cdc.gov)
Medium sized2
- Primary cutaneous CD4 + small/medium-sized pleomorphic T-Cell lymphoproliferative disorder (PC-SMTLD) has been considered as a controversial dermatological disease that has been included in cutaneous T-cell lymphoma group, presenting most commonly as a solitary nodule and/or plaque with a specific and characteristic head and neck predilection. (nih.gov)
- Many medium-sized companies are planning to automate and expand their range of products and services. (kuka.com)
Therapies6
- This finding provides insights into how the population of stem cells is regulated, which could have implications for stem cell-based clinical therapies. (hum-molgen.org)
- Scientists at Johns Hopkins Medicine report they have created a tiny, nanosize container that can slip inside cells and deliver protein-based medicines and gene therapies of any size - even hefty ones attached to the gene-editing tool called CRISPR. (jhu.edu)
- Some medicines, such as antibodies, latch on to targets on the cell's surface receptors, but we don't have good systems for delivering biological medicines straight to the inside of a cell, which is where therapies would have the best chance at working properly and with fewer side effects. (jhu.edu)
- Some commercially available techniques use stripped down forms of viruses - known for their ability to "infect" cells directly - to deliver therapies, although the noninfectious versions of these delivery systems can unleash an unwanted immune system response. (jhu.edu)
- Other therapies aimed at diseased blood cells, for example, are more cumbersome, requiring patients' blood to be removed, then zapped with an electric current that opens pores in the cell membrane to gain entry. (jhu.edu)
- If you are considering requesting a Pre-Pre-IND meeting, you should contact Mercedes Serabian ( [email protected] ), Chief of the Pharmacology/Toxicology Branch of FDA CBER Office of Cell, Tissue, and Gene Therapies, to ask for the Pre-Pre-IND Process checklist, which has a wealth of information that will help you prepare for a productive discussion with FDA. (nih.gov)
Tumor3
- The ability of Sipuleucel-T to effectively enhance an individual's immunity against tumor cells is increasing its market demand. (grandviewresearch.com)
- It is an autologous dendritic cell-based cancer vaccine is created from peripheral blood mononuclear cells (PBMC) of the patient and sensitized with tumor lysate and KLH before developing into dendritic cells (Keyhole Limpet Hemocyanin). (grandviewresearch.com)
- The global circulating tumor cells market size is expected to reach USD 30.78 Billion by 2029 according to a new study by Polaris Market Research. (polarismarketresearch.com)
Endothelial1
- The formation of atherosclerotic lesions involves increased permeability of endothelium to plasma macromolecules (eg, low-density lipoprotein [LDL]), increased turnover of endothelial cells and smooth muscle cells, and increased numbers of intimal macrophages. (medscape.com)
Market size2
- Direct Methanol Fuel Cell Market Size was valued at USD 2.1 Billion in 2021. (marketresearchfuture.com)
- 1) What is the market size of the stem cell banking market in Argentina? (researchandmarkets.com)
20223
- For instance, in May 2022, researchers of the AML-VACCiN consortium, clinically developed a dendritic cell vaccine- DCP-001, so as to vaccinate patients with acute myeloid leukemia to eradicate MRD and to effectively reduce the risk of a relapse. (grandviewresearch.com)
- For instance, in March 2022, Maryland-based Northwest Biotherapeutics declares the initiation of the production of the first personalized dendritic cell-based cancer vaccine at its new production facility in Sawston, UK using advanced therapy medicinal products for the treatment of a glioblastoma case on compassion. (grandviewresearch.com)
- J Cell Sci;135(19)2022 10 01. (bvsalud.org)
Sides of the cell1
- Swabs from the back and sides of the cell phones were cultured. (cdc.gov)
Spatial1
- The spatial heterogeneity of cell sizes observed on leaves suggest that nutrient availability is quite variable on the leaf surface environment. (apsnet.org)
Membrane3
- Another major component, such as membrane, also determines the cost of the fuel cell stack. (marketresearchfuture.com)
- Rising research efforts on membrane components for the fuel cell to improve the membranes, particularly with lower thickness and lower PFSA ratio than the present ones, are anticipated to hold a significant size, share during the forecast period. (marketresearchfuture.com)
- The nanosize container's positive charges interact with the membrane of a cell, and the container is engulfed in a cellular package called an endosome. (jhu.edu)
Microscopy1
- Cells of P. syringae harboring a green fluorescent protein marker gene were visualized by epifluorescence microscopy after recovery from leaves or culture and their size was estimated by analysis of captured digital images. (apsnet.org)
Gene2
- A gene called latexin has a significant effect on the blood stem cell population in young mice, according to a study to be published in the February 2007 issue of Nature Genetics . (hum-molgen.org)
- Using the model, the work then showed how, by mutating the key gene cdr2 , cells can be reprogrammed to trigger division according to cell length. (jic.ac.uk)
Inoculation4
- The length and volume of cells of the plant-pathogenic bacterium Pseudomonas syringae strain B728a were measured in vitro and with time after inoculation on bean leaf surfaces to assess both the effect of nutrient availability on the cell size of P. syringae and, by inference, the variability in nutrient availability in the leaf surface habitat. (apsnet.org)
- The average length of cells originally grown on King's medium B decreased from ≈ 2.5 to ≈ 1.2 μm by 7 days after inoculation on plants. (apsnet.org)
- Although cultured cells exhibited a normal size distribution, the size of cells recovered from bean plants at various times after inoculation was strongly right-hand skewed and was described by a log-normal distribution. (apsnet.org)
- The skewness of the size distribution tended to increase with time after inoculation. (apsnet.org)
Proliferation2
- Among all the currently available immunotherapy strategies, dendritic cell vaccines are the most potent antigen-presenting cells for the effective proliferation of T-cells. (grandviewresearch.com)
- Since activator protein-1 (AP-1) is known to play an important role in the induction of neoplastic transformation and regulation of multiple genes involved in cell proliferation and inflammation, we investigate the potency of TiO2 nanoparticle s on reactive oxygen species (ROS) generation and AP-1 signaling in a mouse epithermal cell line, JB6 cells. (cdc.gov)
Mechanisms6
- Dr Giuseppe Facchetti in the group of Professor Martin Howard, working alongside collaborators in the United States and Spain, developed a predictive mathematical model to demonstrate how cell size-measuring mechanisms work in the model organism fission yeast. (jic.ac.uk)
- Cell size varies between cell types but is tightly regulated by cell intrinsic and extrinsic mechanisms. (bvsalud.org)
- To study mechanisms of spindle and organelle size control, a smaller, related frog, Xenopus tropicalis, has been used to investigate interspecies scaling, and extracts prepared from fertilized eggs at different stages of embryogenesis to study developmental scaling. (nih.gov)
- The scientific goal of my laboratory is to elucidate the molecular mechanisms of cell division and size control. (nih.gov)
- We are studying how these mechanisms generate the diversity of spindle morphologies observed across cell types, and how their alteration contributes to chromosome segregation defects observed in cancer cells and in inviable hybrid frog embryos. (nih.gov)
- The second area is to examine size control mechanisms at the subcellular, cellular and organism levels. (nih.gov)
Mesenchymal1
- The therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) on brain infarction area (BIA) and neurological status in a rat model of acute ischemic stroke (IS) was investigated. (biomedcentral.com)
Rechargeable batteries1
- Additionally, the superior energy density of these fuel cells compared to rechargeable batteries translates to more conversation time & support consumer demand which also adds an advantage. (marketresearchfuture.com)
Proteins2
- The cell nucleus is blue, endosomes (which sequester materials taken up by cells) are labeled in pink, and the immunoglobulin proteins are labeled with a green fluorescent tag. (jhu.edu)
- That's not the case with many biological medicines, which consist of highly charged, large proteins and nucleic acids that tend to repel off cells. (jhu.edu)
Overexpression3
- They transplanted these cells into recipient mice and found that overexpression of latexin had the effect of reducing the number of blood stem cells, suggesting that it acts as an inhibitor of stem cell expansion. (hum-molgen.org)
- We provide evidence that overexpression of the H3K36 demethylase KDM4A or the oncohistone H3.3K36M also increase cell size . (bvsalud.org)
- In addition, ectopic overexpression of a decoy SRI domain increased cell size , suggesting that the relevant substrate is engaged by SETD2 via its SRI domain. (bvsalud.org)
Nucleus1
- Several papers ended up relating to nucleus, cell and embryo size and space as well as chromatin , which is very interesting. (ipscell.com)
Molecules1
- Discovering how molecules relay geometrical size information is a key step on the road to answering this fundamental question," says Dr Facchetti. (jic.ac.uk)
Stem cells4
- Twenty-five years ago, Gary Van Zant and colleagues showed that the size of the blood stem cell population can vary in different strains of mice, with a strain called D2 typically having at least three times as many blood stem cells as a strain called B6. (hum-molgen.org)
- What are stem cells? (ipscell.com)
- I did a post where I took a look at stem cells for knee arthritis and other arthritis and the data so far are not compelling. (ipscell.com)
- So do stem cells or PRP work for arthritis? (ipscell.com)
Immune2
- Applicants are encouraged to submit multi-project research programs that propose to study immune responses to allergens at the level of epitope-specific T cell subsets, including comparative or interventional studies in humans. (nih.gov)
- Applicants are also encouraged to capitalize on the availability of allergen T cell epitopes, including those available through the NIAID-funded Immune Epitope Database and Analysis Resource (IEDB) . (nih.gov)
Cancer11
- Cancer cells that have split away from the main lump and appear in the circulatory system as single units or clusters are known as CTCs. (polarismarketresearch.com)
- Cell size control is important for cell function, and changes in cell size are frequently observed in cancer . (bvsalud.org)
- Basal cell cancer is the most common form of cancer in the United States. (medlineplus.gov)
- Most skin cancers are basal cell cancer. (medlineplus.gov)
- With basal cancer, cells in this layer are the ones that become cancerous. (medlineplus.gov)
- Basal cell cancer is almost always slow-growing. (medlineplus.gov)
- Basal cell cancer usually grows slowly and is often painless. (medlineplus.gov)
- A skin biopsy must be done to confirm basal cell cancer or other skin cancers. (medlineplus.gov)
- Treatment depends on the size, depth, and location of the skin cancer and your overall health. (medlineplus.gov)
- Basal cell skin cancer almost never spreads beyond the original location. (medlineplus.gov)
- This collection of monographs on selected viruses provide cancer hazard evaluations for the following human viruses: Epstein-Barr virus, Kaposi sarcoma herpesvirus, human immunodeficiency virus-1, human T-cell lymphotropic virus-1, and Merkel cell polyomavirus for potential listing in the Report on Carcinogens (RoC). (nih.gov)
Cultures2
- Indistinguishable isolates were recovered from cell- phones and hand cultures (lanes 11 and 12), and 2 hand cultures (lanes 18 and 19). (cdc.gov)
- strain recovered from cell phones (lane 1), personnel hand cultures quinolones, tetracyclines, polymyxin (lane 2), and patients with skin colonization (lanes 3-11). (cdc.gov)
Defects1
- Critical-size defects in rat calvarias were treated with blood clot (G1), autogenous bone (G2), HA-COL (G3) and HA-COL combined with PDC (G4) (n=40), and then analyzed 1 and 3 months after surgeries. (unesp.br)
CRISPR1
- For an even greater challenge, Rui created a nanopackage containing a CRISPR-based protein and nucleic acid complex that could turn off a green fluorescence signal or cause the cells to glow red when the CRISPR compound cut part of a cell's genome. (jhu.edu)
Fluorescence1
- Representative fields of view are shown for 20X fluorescence images (intensity adjusted image displayed for illustration purposes only) (A) or processed images (B). Individual cells were identified from the processed images and the integrated fluorescence intensity and area were calculated. (nih.gov)
Methods1
- D, E: WGA-stained HEK293 (D) and U87 cells (E) were subjected to flow cytometry (see Methods), and the correlation between FSC and WGA staining intensity is shown. (nih.gov)
Molecular2
- Our collaborative research aims to provide new insight into principles of mitosis and size scaling, as well as the molecular basis of variation that contributes to genomic instability and evolution. (nih.gov)
- The four centers conduct laboratory experiments on rodent and cell culture models to characterize molecular and morphologic changes in the mammary gland over the life span and to determine how environmental exposures affect mammary gland development and susceptibility to carcinogenesis. (nih.gov)
Bone3
- The authors experimentally tested the role of latexin by infecting cultured bone marrow cells with a virus promoting the expression of high levels of latexin. (hum-molgen.org)
- The aim of this study was to evaluate the bone repair using autogenous periosteum-derived cells (PDC) and bovine anorganic apatite and collagen (HA-COL). PDC from Wistar rats (n=10) were seeded on HA-COL discs and subjected to osteoinduction during 6 days. (unesp.br)
- At 3 months, histopathological analysis showed the presence of ossification islets in G1, which was more evident in G2, homogeneous new bone around HA-COL in G3 and heterogeneous new bone around HA-COL in G4 in addition to moderate presence of foreign body cells in G3 and G4. (unesp.br)
Fuel cell4
- Expanding mindfulness about clean energy and interest for zero outflow fuel sources drives the interest in the Direct Methanol Fuel Cell Market share. (marketresearchfuture.com)
- The bipolar players account for the dominating direct methanol fuel cell market share. (marketresearchfuture.com)
- The catalyst is one of the important elements in a fuel cell as it influences the total system cost on large-scale production. (marketresearchfuture.com)
- Based on Application, the Direct Methanol Fuel Cell market segmentation includes Portable, Stationary and Transportation. (marketresearchfuture.com)
Report3
- The country research report on Argentina stem cell banking market is a customer intelligence and competitive study of the Argentina market. (researchandmarkets.com)
- The companies and dealers/distributors profiled in the report include manufacturers & suppliers of the stem cell banking market in Argentina. (researchandmarkets.com)
- The report on Argentina stem cell banking market provides a detailed analysis of segments in the market based on cell type, service type, and application. (researchandmarkets.com)
Smaller1
- The average cell length of bacteria grown on leaves was significantly smaller than that of cultured cells, and approached that of cells starved in phosphate buffer for 24 h. (apsnet.org)
Treatments1
- The assay consisted of 4 treatments: two container sizes by two BA conditions (with and without). (techscience.com)
Lung1
- For these short fibers, which can be fully engulfed by lung cells and do not dissolve in airway fluids in less than a few weeks, their clearance will be similar to other mineral and vitreous particles. (cdc.gov)
Therapeutic1
- Creavax is a therapeutic vaccine for renal cell carcinoma produced by Creagene in 2007. (grandviewresearch.com)
Culture2
- The reduced cell size of P. syringae B728a on plants was readily reversible when recovered cells were grown in culture. (apsnet.org)
- To test their invention, Rui made a nanocontainer of a small protein and fed it to mouse kidney cells in culture dishes. (jhu.edu)
Study2
- The study experimentally analysed cells of different widths to show that cells divide according to a fixed surface area. (jic.ac.uk)
- Also, factors that are driving and restraining the stem cell banking market are highlighted in the study. (researchandmarkets.com)
Reagents2
- The purpose of this Funding Opportunity Announcement (FOA) is to support studies to understand the role of allergen epitope-specific T-cell responses in the pathogenesis and treatment of allergic diseases by utilizing allergen epitope-specific reagents. (nih.gov)
- This FOA is seeking applications from single institutions, or consortia of institutions, proposing research to understand the role of allergen epitope-specific T-cell responses in the pathogenesis and treatment of allergic diseases including allergic rhinitis, asthma and food allergy, by utilizing allergen epitope-specific reagents. (nih.gov)
Widely1
- The nanoparticle's cargo has spread widely through most of the cells (green) without it being trapped in endosomes. (jhu.edu)
Primarily1
- Other particles may be engulfed by epithelial cells, primarily in the vicinity of the bronchial-alveolar duct junctions, and retained for much longer periods, with gradual removal to lymph nodes. (cdc.gov)
Extensively1
- Identification, characterization and validation of new T-cell epitopes for allergens that have not been previously extensively examined (e.g. fungal allergens or food antigens such as milk), will also be supported under this FOA. (nih.gov)