Cell Respiration
Oxygen Consumption
Mitochondria
Electron Transport Complex IV
Oxygen
Nitric Oxide
Respiration
Cheyne-Stokes Respiration
Oxidative Phosphorylation
Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury. (1/1245)
We investigated mechanisms of cell death during hypoxia/reoxygenation of cultured kidney cells. During glucose-free hypoxia, cell ATP levels declined steeply resulting in the translocation of Bax from cytosol to mitochondria. Concurrently, there was cytochrome c release and caspase activation. Cells that leaked cytochrome c underwent apoptosis after reoxygenation. ATP depletion induced by a mitochondrial uncoupler resulted in similar alterations even in the presence of oxygen. Moreover, inclusion of glucose during hypoxia prevented protein translocations and reoxygenation injury by maintaining intracellular ATP. Thus, ATP depletion, rather than hypoxia per se, was the cause of protein translocations. Overexpression of Bcl-2 prevented cytochrome c release and reoxygenation injury without ameliorating ATP depletion or Bax translocation. On the other hand, caspase inhibitors did not prevent protein translocations, but inhibited apoptosis during reoxygenation. Nevertheless, they could not confer long-term viability, since mitochondria had been damaged. Omission of glucose during reoxygenation resulted in continued failure of ATP production, and cell death with necrotic morphology. In contrast, cells expressing Bcl-2 had functional mitochondria and remained viable during reoxygenation even without glucose. Therefore, Bax translocation during hypoxia is a molecular trigger for cell death during reoxygenation. If ATP is available during reoxygenation, apoptosis develops; otherwise, death occurs by necrosis. By preserving mitochondrial integrity, BCL-2 prevents both forms of cell death and ensures cell viability. (+info)Beneficial effects of raxofelast (IRFI 016), a new hydrophilic vitamin E-like antioxidant, in carrageenan-induced pleurisy. (2/1245)
1. Peroxynitrite is a strong oxidant that results from reaction between NO and superoxide. It has been recently proposed that peroxynitrite plays a pathogenetic role in inflammatory processes. Here we have investigated the therapeutic efficacy of raxofelast, a new hydrophilic vitamin E-like antioxidant agent, in rats subjected to carrageenan-induced pleurisy. 2. In vivo treatment with raxofelast (5, 10, 20 mg kg(-1) intraperitoneally 5 min before carrageenan) prevented in a dose dependent manner carrageenan-induced pleural exudation and polymorphonuclear migration in rats subjected to carrageenan-induced pleurisy. Lung myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels, as well as histological organ injury were significantly reduced by raxofelast. 3. Immunohistochemical analysis for nitrotyrosine, a footprint of peroxynitrite, revealed a positive staining in lungs from carrageenan-treated rats. No positive nitrotyrosine staining was found in the lungs of the carrageenan-treated rats, which received raxofelast (20 mg kg 1) treatment. 4. Furthermore, in vivo raxofelast (5, 10, 20 mg kg(-1)) treatment significantly reduced peroxynitrite formation as measured by the oxidation of the fluorescent dihydrorhodamine 123, prevented the appearance of DNA damage, the decrease in mitochondrial respiration and partially restored the cellular level of NAD+ in ex vivo macrophages harvested from the pleural cavity of rats subjected to carrageenan-induced pleurisy. 5. In conclusion, our study demonstrates that raxofelast, a new hydrophilic vitamin E-like antioxidant agent, exerts multiple protective effects in carrageenan-induced acute inflammation. (+info)Cytosolic Ca2+ movements of endothelial cells exposed to reactive oxygen intermediates: role of hydroxyl radical-mediated redox alteration of cell-membrane Ca2+ channels. (3/1245)
1. The mode of action of reactive oxygen intermediates in cysosolic Ca2+ movements of cultured porcine aortic endothelial cells exposed to xanthine/xanthine oxidase (X/XO) was investigated. 2. Cytosolic Ca2+ movements provoked by X/XO consisted of an initial Ca2+ release from thapsigargin-sensitive intracellular Ca2+ stores and a sustained Ca2+ influx through cell-membrane Ca2+ channels. The Ca2+ movements from both sources were inhibited by catalase, cell-membrane permeable iron chelators (o-phenanthroline and deferoxamine), a *OH scavenger (5,5-dimethyl-1-pyrroline-N-oxide), or an anion channel blocker (disodium 4, 4'-diisothiocyano-2, 2'-stilbenedisulphonic acid), suggesting that *O2- influx through anion channels was responsible for the Ca2+ movements, in which *OH generation catalyzed by intracellular transition metals (i.e., Haber-Weiss cycle) was involved. 3. After an initial Ca2+ elevation provoked by X/XO, cytosolic Ca2+ concentration decreased to a level higher than basal levels. Removal of X/XO slightly enhanced the Ca2+ decrease. Extracellular addition of sulphydryl (SH)-reducing agents, dithiothreitol or glutathione, after the removal of X/XO accelerated the decrement. A Ca2+ channel blocker, Ni2+, abolished the sustained increase in Ca2+, suggesting that Ca2+ influx through cell-membrane Ca2+ channels was extracellularly regulated by the redox state of SH-groups. 4. The X/XO-provoked change in cellular respiration was inhibited by Ni2+ or dithiothreitol as well as inhibitors of Haber-Weiss cycle, suggesting that Ca2+ influx was responsible for *OH-mediated cytotoxicity. We concluded that intracellular *OH generation was involved in the Ca2+ movements in endothelial cells exposed to X/XO. Cytosolic Ca2+ elevation was partly responsible for the oxidants-mediated cytotoxicity. (+info)Myogenin induces a shift of enzyme activity from glycolytic to oxidative metabolism in muscles of transgenic mice. (4/1245)
Physical training regulates muscle metabolic and contractile properties by altering gene expression. Electrical activity evoked in muscle fiber membrane during physical activity is crucial for such regulation, but the subsequent intracellular pathway is virtually unmapped. Here we investigate the ability of myogenin, a muscle-specific transcription factor strongly regulated by electrical activity, to alter muscle phenotype. Myogenin was overexpressed in transgenic mice using regulatory elements that confer strong expression confined to differentiated post-mitotic fast muscle fibers. In fast muscles from such mice, the activity levels of oxidative mitochondrial enzymes were elevated two- to threefold, whereas levels of glycolytic enzymes were reduced to levels 0.3-0.6 times those found in wild-type mice. Histochemical analysis shows widespread increases in mitochondrial components and glycogen accumulation. The changes in enzyme content were accompanied by a reduction in fiber size, such that many fibers acquired a size typical of oxidative fibers. No change in fiber type-specific myosin heavy chain isoform expression was observed. Changes in metabolic properties without changes in myosins are observed after moderate endurance training in mammals, including humans. Our data suggest that myogenin regulated by electrical activity may mediate effects of physical training on metabolic capacity in muscle. (+info)Mitochondrial group II introns, cytochrome c oxidase, and senescence in Podospora anserina. (5/1245)
Podospora anserina is a filamentous fungus with a limited life span. It expresses a degenerative syndrome called senescence, which is always associated with the accumulation of circular molecules (senDNAs) containing specific regions of the mitochondrial chromosome. A mobile group II intron (alpha) has been thought to play a prominent role in this syndrome. Intron alpha is the first intron of the cytochrome c oxidase subunit I gene (COX1). Mitochondrial mutants that escape the senescence process are missing this intron, as well as the first exon of the COX1 gene. We describe here the first mutant of P. anserina that has the alpha sequence precisely deleted and whose cytochrome c oxidase activity is identical to that of wild-type cells. The integration site of the intron is slightly modified, and this change prevents efficient homing of intron alpha. We show here that this mutant displays a senescence syndrome similar to that of the wild type and that its life span is increased about twofold. The introduction of a related group II intron into the mitochondrial genome of the mutant does not restore the wild-type life span. These data clearly demonstrate that intron alpha is not the specific senescence factor but rather an accelerator or amplifier of the senescence process. They emphasize the role that intron alpha plays in the instability of the mitochondrial chromosome and the link between this instability and longevity. Our results strongly support the idea that in Podospora, "immortality" can be acquired not by the absence of intron alpha but rather by the lack of active cytochrome c oxidase. (+info)Oxygen-dependent inhibition of respiration in isolated renal tubules by nitric oxide. (6/1245)
BACKGROUND: The partial pressure (tension) of oxygen (PO2) in the kidney medulla has been established to be lower than that of the cortex. The kidney medulla has been shown to be particularly sensitive to hypoxia. However, the measured PO2 in the kidney medulla is sufficient to support maximal respiration. It has been recently shown that endogenously produced nitric oxide (NO) may inhibit oxygen consumption in the kidney. We studied whether NO plays a role in hypersensitivity of the kidney medulla to hypoxia. METHODS: We studied the effect of added NO on isolated cortical and outer medullary renal tubules in simultaneous oxygen consumption and NO measurements at different oxygen concentrations. RESULTS: We found that NO could potently and reversibly inhibit respiration at nanomolar concentrations. The inhibitory effect of NO was markedly increased at low physiological oxygen concentrations. The effect of NO was cGMP independent because the selective guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) at a 10 microM concentration had no effect on basal or NO-inhibited respiration. The value for half-maximal NO-mediated inhibition of respiration was virtually identical to that found in isolated mitochondria, and therefore, NO was most likely directly acting on mitochondria. Interestingly, we found no differences in sensitivity to NO-mediated inhibition between outer medullary and cortical tubules. CONCLUSIONS: We suggest that because of its low PO2, the renal outer medulla is more sensitive to hypoxia, not because of the low PO2 as such, but probably because of the competition between NO and oxygen to control respiration. (+info)Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase. (7/1245)
We previously reported that cardiac reperfusion results in declines in mitochondrial NADH-linked respiration. The degree of inactivation increased with age and was paralleled by modification of protein by the lipid peroxidation product 4-hydroxy-2-nonenal. To gain insight into potential sites of oxidative damage, the present study was undertaken to identify specific mitochondrial protein(s) inactivated during ischemia and reperfusion and to determine which of these losses in activity are responsible for observed declines in mitochondrial respiration. Using a Langendorff rat heart perfusion protocol, we observed age-dependent inactivation of complex I during ischemia and complex IV and alpha-ketoglutarate dehydrogenase during reperfusion. Although losses in complex I and IV activities were found not to be of sufficient magnitude to cause declines in mitochondrial respiration, an age-related decrease in complex I activity during ischemia may predispose old animals to more severe oxidative damage during reperfusion. It was determined that inactivation of alpha-ketoglutarate dehydrogenase is responsible, in large part, for observed reperfusion-induced declines in NADH-linked respiration. alpha-Ketoglutarate dehydrogenase is highly susceptible to 4-hydroxy-2-nonenal inactivation in vitro. Thus, our results suggest a plausible mechanism for age-dependent, reperfusion-induced declines in mitochondrial function and identify alpha-ketoglutarate dehydrogenase as a likely site of free radical-mediated damage. (+info)Respiratory uncoupling induces delta-aminolevulinate synthase expression through a nuclear respiratory factor-1-dependent mechanism in HeLa cells. (8/1245)
Nuclear respiratory factor (NRF)-1 appears to be important for the expression of several respiratory genes, but there is no direct evidence that NRF-1 transduces a physiological signal into the production of an enzyme critical for mitochondrial biogenesis. We generated HeLa cells containing plasmids allowing doxycycline-inducible expression of uncoupling protein (UCP)-1. In the absence of doxycycline, UCP-1 mRNA and protein were undetectable. In the presence of doxycycline, UCP-1 was expressed and oxygen consumption doubled. This rise in oxygen consumption was associated with an increase in NRF-1 mRNA. It was also associated with an increase in NRF-1 protein binding activity as determined by electrophoretic mobility shift assay using a functional NRF-1 binding site from the delta-aminolevulinate (ALA) synthase promoter. Respiratory uncoupling also caused a time-dependent increase in protein levels of ALA synthase, an early marker for mitochondrial biogenesis. ALA synthase induction by respiratory uncoupling was prevented by transfecting cells with an oligonucleotide antisense to the region of the NRF-1 initiation codon; a scrambled oligonucleotide with the same base composition had no effect. Respiratory uncoupling increases oxygen consumption and lowers energy reserves. In HeLa cells, uncoupling also increases ALA synthase, an enzyme critical for mitochondrial respiration, but only if translatable mRNA for NRF-1 is available. These data suggest that the transcription factor NRF-1 plays a key role in cellular adaptation to energy demands by translating physiological signals into an increased capacity for generating energy. (+info)The term "Cheyne-Stokes" was first used to describe this type of respiration by British physician William Cheyne in 1832, and later popularized by John Stokes in 1854. It is also known as "stop-and-go breathing" or "alternating apnea."
Cheyne-Stokes respiration is thought to be caused by changes in the autonomic nervous system that regulate breathing, which can be influenced by various factors such as heart failure, anemia, and medications. The exact mechanisms underlying this phenomenon are not fully understood, but it is believed to involve a complex interplay between cardiac output, venous return, and respiratory muscle function.
The clinical significance of Cheyne-Stokes respiration lies in its potential impact on patient outcomes. It can lead to hypoxia (lack of oxygen) and acidosis (excessive acidity), which can worsen cardiorespiratory symptoms and increase the risk of complications such as heart failure exacerbation, respiratory failure, and death.
Diagnosis of Cheyne-Stokes respiration typically involves monitoring of arterial blood gases, electrocardiography (ECG), and chest radiography. Treatment strategies may include addressing underlying conditions such as heart failure or COPD, adjusting medications, and providing respiratory support as needed.
In summary, Cheyne-Stokes respiration is an abnormal breathing pattern characterized by repetitive cycles of shallow and deep breaths, with periods of apnea and hyperpnea. It is commonly seen in patients with cardiorespiratory conditions and can have significant clinical implications.
Metabolic pathway
Pressure flow hypothesis
Antimycin A
CoRR hypothesis
Ecosystem respiration
Bioluminescence
Lactate shuttle hypothesis
Dioxygen in biological reactions
Paracytophagy
Lymphocyte expansion molecule
Thermoregulation in humans
Cytochrome c oxidase
Chemesthesis
Absorption of water
Strobilurin
Glycolysis
COX4I1
Riboflavin
Dihydrokavain
Dihydrolipoyl transacetylase
Bernhard Kadenbach
COX4I2
Stem cell fat grafting
Nuclear receptor 4A3
DAP3
Mercury methylation
Respiratory complex I
Seed testing
Britton Chance
Biology
Robot research initiative
Metabolism
Manju Ray
Sulfolobus
Senescence
Food and biological process engineering
Mitochondrial DNA
Pre-Bötzinger complex
Rhodobacter sphaeroides
Beatrice M. Sweeney
Scyphozoa
PM20D1
NAD+ kinase
Kryptonia
Pyrobaculum
Blood doping
Chlorophyll fluorescence
Kubitzkia
Wilson-Mikity syndrome
Copepod
Bronchoconstriction
Zymology
Beggiatoa
Door handle bacteria
Barbel (anatomy)
Brain
Origin of speech
Environmental DNA
Hekiru Shiina
Cell Respiration Laboratory Kit for Classic AP* Biology Lab 5
MicrocircuitDB: Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
Cell Respiration For Dummies
Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs. | Cell Metab;35(2): 299-315.e8, 2023 02 07. |...
Subjects: Cell Respiration - Digital Collections - National Library of Medicine Search Results
NIOSHTIC-2 Publications Search - 20045072 - Lung epithelial cells resist influenza A infection by inducing the expression of...
Zellatmung IV. Mitteilung: Uber den Oxydationsmechanismus der Kartoffeln [Cell respiration IV: On the oxidation mechanism of...
Zellatmung V. Mitteilung: Uber den Oxydationsmechanismus einiger Pflanzen [Cell respiration V: On the oxidation mechanism of...
Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer | Scientific Reports
High-fat feeding increases fatty acid oxidation rates and uncouples respiration in cardiac mitochondria - Oxford Stem Cell...
Biology for the IB Diploma | Biology for the IB Diploma | Cambridge University Press
Structure-activity relationships for perfluoroalkane-induced in vitro interference with rat liver mitochondrial respiration -...
Zellatmung V. Mitteilung: Uber den Oxydationsmechanismus einiger Pflanzen [Cell respiration V: On the oxidation mechanism of...
Cellulite
Frontiers | Elucidation of Triacylglycerol Overproduction in the C4 Bioenergy Crop Sorghum bicolor by Constraint-Based Analysis
NIOSHTIC-2 Search Results - Full View
Prof Peter Williams | School of Ocean Sciences | Bangor University
Patient's History of Medical Cannabis | Medical Cannabis Advocacy - Americans for Safe Access
Creator: Szent-Gyorgyi, Albert, 1893-1986 / Genre: Articles / Story Section: Searching for a Scientific Home, 1919-1930 -...
Lin S[au] - Search Results - PubMed
Publication Detail
Publications - Lee S. Weinstein, M.D. - NIDDK
Symptomatic hyperlactataemia: an emerging complication of antiretroviral therapy - PubMed
PhytOxygene Mask - Mary Cohr
PDF) Sunscreen and Prevention of Skin Aging A Randomized Trial
Langerhans Cell Histiocytosis Imaging: Practice Essentials, Radiography, Computed Tomography
Mitochondrial respiration7
- Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs. (bvsalud.org)
- The current investigation was designed to explore structure-activity relationships by which PFAAs interfere with mitochondrial respiration in vitro. (nih.gov)
- 8. Assaying Mitochondrial Respiration as an Indicator of Cellular Metabolism and Fitness. (nih.gov)
- 2. Licochalcone A inhibits hypoxia-inducible factor-1α accumulation by suppressing mitochondrial respiration in hypoxic cancer cells. (nih.gov)
- 16. Capsaicin inhibits HIF-1α accumulation through suppression of mitochondrial respiration in lung cancer cells. (nih.gov)
- First, they measured mitochondrial respiration using two types of fuel: glucose and fat. (nih.gov)
- Dr. Hanson and her colleagues did not see significant differences in mitochondrial respiration, the cell's primary energy-producing method, between healthy and ME/CFS cells at rest or after activation. (nih.gov)
Metabolism13
- This phenomenon is tissue due to diffusion limitation but is due to the change in cell metabolism because microstructure-related and is essential for understanding the diffusion NMR there is not enough oxygen, consistent with Michaelis-Menten kinetics. (nih.gov)
- From this my interest broadened to overall heterotrophic metabolism - respiration. (bangor.ac.uk)
- This work led on to the question of the balance of metabolism (photosynthesis versus respiration) in the oceans and I played a leading role in the debate over purported ocean heterotrophy. (bangor.ac.uk)
- 4. Measurement of Oxygen Consumption Rate (OCR) and Extracellular Acidification Rate (ECAR) in Culture Cells for Assessment of the Energy Metabolism. (nih.gov)
- Promotes cell respiration to boost cell metabolism. (marycohr.com)
- Similar to cyanide, sodium azide and hydrozoic acid also interfere with cellular respiration and aerobic metabolism, preventing the cells from using oxygen. (cdc.gov)
- Oxygen is required for cell metabolism. (vernier.com)
- 8. Excess glucose induces hypoxia-inducible factor-1α in pancreatic cancer cells and stimulates glucose metabolism and cell migration. (nih.gov)
- Using innovative technology, researchers analyzed metabolism in ME/CFS CD4 and CD8 T cells. (nih.gov)
- Research by Alexandra Mandarano and collaborators in the laboratory of Maureen Hanson, Ph.D., professor of molecular biology and genetics at Cornell University in Ithaca, New York, examined biochemical reactions involved in energy production, or metabolism, in two specific types of immune cells obtained from 45 healthy controls and 53 people with ME/CFS. (nih.gov)
- Dr. Hanson's team examined associations between cytokines, chemical messengers that send instructions from one cell to another, and T cell metabolism. (nih.gov)
- In addition, the presence of cytokines that cause inflammation unexpectedly correlated with decreased metabolism in T cells. (nih.gov)
- Future research studies will examine metabolism in other subsets of immune cells. (nih.gov)
Photosynthesis1
- Extending iTJC1414 to a four-cell diel model we simulate C 4 photosynthesis in mature leaves with the principal photo-assimilatory product being replaced by TAG produced at different levels. (frontiersin.org)
Cellular6
- Spin-Labeled Uni-Lamellar Vesicles as an Oxygen Sensitive Analyte for port the idea that in addition to acetylcholine, additional neurotransmitters and/ Measurement of Cellular Respiration using Rat Dopaminergic Neuronal or neuromodulators are also released from cholinergic synapses. (nih.gov)
- 9. Quercetin exerts an inhibitory effect on cellular bioenergetics of the B164A5 murine melanoma cell line. (nih.gov)
- 12. Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer. (nih.gov)
- 15. Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons. (nih.gov)
- Mitochondria are organelles in all cells that use oxygen to convert the fuel from food into chemical energy that a cell can use, in a process called oxidative phosphorylation, or more generally, cellular respiration. (nih.gov)
- Feeds your body cells with cellular Oxygen. (keywen.com)
Induces2
Carbon dioxide2
- The waste products are carbon dioxide and water which leave the cell and are eliminated from the body of the plant or animal. (educationquizzes.com)
- This prevents the cell from 'loading' oxygen or carbon dioxide - essentially preventing respiration. (zmescience.com)
Lung3
- Lung epithelial cells resist influenza A infection by inducing the expression of cytochrome c oxidase VIc which is modulated by miRNA 4276. (cdc.gov)
- Definitive diagnosis, if necessary, can be made by identification of Langerhans cell granulomas in lung biopsy samples acquired by video-assisted thoracoscopy. (medscape.com)
- Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate. (nih.gov)
20161
- 1 . Short SM, Morse TM, McTavish TS, Shepherd GM, Verhagen JV (2016) Respiration Gates Sensory Input Responses in the Mitral Cell Layer of the Olfactory Bulb. (yale.edu)
20231
- Cell Metab;35(2): 299-315.e8, 2023 02 07. (bvsalud.org)
Alveolar1
- Within the first 3 h of infection with influenza virus, significant down-regulation of hsa-miRNA-4276 (miRNA-4276) is followed by a 2-fold increase in cytochrome c oxidase VIC (COX6C) mRNA was found to occur in human alveolar and bronchial epithelial cells. (cdc.gov)
Aerobic9
- The two forms of respiration - aerobic and anaerobic - are both looked at in GCSE Biology. (educationquizzes.com)
- This quiz focusses on aerobic respiration, in which glucose and oxygen react to release energy. (educationquizzes.com)
- There are two types of respiration, depending on the levels of oxygen available to a cell - aerobic if there is plenty of oxygen or anaerobic if the oxygen supply is insufficient. (educationquizzes.com)
- Aerobic respiration gives a greater yield of energy than anaerobic respiration. (educationquizzes.com)
- During aerobic respiration, glucose reacts with oxygen to release energy. (educationquizzes.com)
- The energy released by aerobic respiration is used in a number of different ways. (educationquizzes.com)
- How much do you know about aerobic respiration? (educationquizzes.com)
- What is the waste gas released by aerobic respiration? (educationquizzes.com)
- One reactant in aerobic respiration is oxygen. (educationquizzes.com)
Cell's1
- It's like the brains behind the cell, and it holds the cell's genetic material, such as DNA. (dummies.com)
Enzymes2
- Respiration occurs inside the the mitochondria of a cell and is actually carried out through a complex set of chemical reactions controlled by enzymes. (educationquizzes.com)
- Animal cells have lysosomes (sacs of enzymes), which aren't found in plant cells. (dummies.com)
Inhibition2
- To explore interactions between respiration, inhibition, and olfaction, experiments using light to active channel rhodopsin in sensory neurons expressing Olfactory Marker Protein were performed in mice and modeled in silico. (yale.edu)
- Through this dual mechanism, SFXN4 inhibition heightens ovarian cancer cell sensitivity to DNA-damaging drugs and DNA repair inhibitors used in ovarian cancer therapy, such as cisplatin and PARP inhibitors. (nature.com)
Metabolic2
Promotes1
- 6. Hypoxia-inducible factor-1alpha promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts. (nih.gov)
Glucose5
- 7. Brusatol inhibits HIF-1 signaling pathway and suppresses glucose uptake under hypoxic conditions in HCT116 cells. (nih.gov)
- 19. HIF-1α activation under glucose deprivation plays a central role in the acquisition of anti-apoptosis in human colon cancer cells. (nih.gov)
- They found that the mitochondria in the hearts of high-capacity runners had more efficient respiration, including burning more fats over glucose as fuel, and were more resistant to oxidative stress than mitochondria in low-capacity runners. (nih.gov)
- With glucose alone, respiration was essentially the same in both rat strains. (nih.gov)
- In contrast, in the presence of fats, either alone or combined with glucose, HCR cells had significantly higher respiration than LCR cells. (nih.gov)
Levels of oxygen1
- Appropriate levels of oxygen are vital to support cell respiration. (keywen.com)
Ovarian cancer cell1
- 14. Bioenergetic analysis of ovarian cancer cell lines: profiling of histological subtypes and identification of a mitochondria-defective cell line. (nih.gov)
Immune5
- New findings published in the Journal of Clinical Investigation suggest that specific immune T cells from people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) show disruptions in the way they produce energy. (nih.gov)
- Investigators focused on CD4 T cells, which alert other immune cells about invading pathogens, and CD8 T cells, which attack infected cells. (nih.gov)
- Our work demonstrates the importance of looking at particular types of immune cells that have different jobs to do, rather than looking at them all mixed together, which can hide problems specific to particular cells," said Dr. Hanson. (nih.gov)
- Additional studies focusing on specific cell types will be important to unravel what's gone wrong with immune defenses in ME/CFS. (nih.gov)
- The findings revealed different, and often opposite, patterns between healthy and ME/CFS cells, suggesting changes in the immune system. (nih.gov)
Dummies1
- img src=\"https://www.dummies.com/wp-content/uploads/483378.image0.jpg\" height=\"450\" alt=\"Basic structures of plant and animal cells. (dummies.com)
Plant6
- [ 2 , 3 ] Pulmonary Langerhans cell histiocytosis is considered a reactive proliferation of dendritic Langerhans cells to chronic tobacco-derived plant proteins resulting from incomplete combustion, but it can also occur as a tumor-like systemic disease in children. (medscape.com)
- Plant cells have a firm cell wall that supports and protects the cell. (dummies.com)
- Plant cells have larger vacuoles (storage areas) than those found in animal cells. (dummies.com)
- Unlike animal cells, many plant cells contain chloroplasts, which contain chlorophyll, a chemical that helps plants create food with the help of sunlight. (dummies.com)
- Most plant and fungus cells don't. (dummies.com)
- Basic structures of plant and animal cells. (dummies.com)
Experiments1
- In parallel experiments, the researchers evaluated mitochondrial function in heart cells isolated from the rat strains at different ages. (nih.gov)
Proteins1
- Are these symbols of the proteins or "worker molecules" made by a cell still functional? (nih.gov)
Cancer cells17
- Here we demonstrate that SFXN4 plays a role in synthesis of iron sulfur clusters (Fe-S) in ovarian cancer cells and ovarian cancer tumor-initiating cells, and that knockdown of SFXN4 inhibits Fe-S biogenesis in ovarian cancer cells. (nature.com)
- Sensitization is achieved even in drug resistant ovarian cancer cells. (nature.com)
- Through its participation in the Fenton reaction and other pathways, excess iron contributes to the oxidative fragility of cancer cells and heightens cancer cell susceptibility to agents that trigger oxygen radical-mediated cell death 3 . (nature.com)
- Sensitivity to oxidative stress has long been considered an Achilles heel of cancer cells and is now being exploited in clinical trials 7 , 8 . (nature.com)
- 7. Using Seahorse Machine to Measure OCR and ECAR in Cancer Cells. (nih.gov)
- Cancer cells grow and multiply uncontrollably. (nih.gov)
- This uncontrolled growth of cancer cells results in the formation of malignant tumors. (nih.gov)
- Cancer cells grow and divide in an uncontrolled way. (nih.gov)
- Cancer cells do not receive or respond to normal signals sent by other cells (like signals to stop growing or to die). (nih.gov)
- Do cancer cells have a finite life expectancy, like that of a candle? (nih.gov)
- How do cancer cells get their energy? (nih.gov)
- Cancer cells often switch to the less efficient process of glycolysis, or burning sugar to generate energy, rather than using oxygen through respiration as the "normal cell" does. (nih.gov)
- Hypoxic cancer cells are known to be relatively resistant to radiation killing compared with well oxygenated healthy cells [2,3,7-9]. (who.int)
- 4. Biphasic Regulation of Mitogen-Activated Protein Kinase Phosphatase 3 in Hypoxic Colon Cancer Cells. (nih.gov)
- 13. The anti-proliferative effect of L-carnosine correlates with a decreased expression of hypoxia inducible factor 1 alpha in human colon cancer cells. (nih.gov)
- 18. Rhapontigenin inhibited hypoxia inducible factor 1 alpha accumulation and angiogenesis in hypoxic PC-3 prostate cancer cells. (nih.gov)
- 20. ERRα augments HIF-1 signalling by directly interacting with HIF-1α in normoxic and hypoxic prostate cancer cells. (nih.gov)
Tissues4
- Langerhans cell histiocytosis (LCH) describes a group of syndromes that share the common pathologic feature of infiltration of involved tissues by Langerhans cells. (medscape.com)
- The tumors can invade and spread to other tissues and organs in our bodies, destroying normal cells along the way. (nih.gov)
- As cells grow and divide, they arrange themselves in a particular way to form tissues. (nih.gov)
- All human cells, tissues, and organs require oxygen to function. (keywen.com)
Biology1
- In the Cell Respiration Classic Lab Kits for AP ® Biology, study the amount of oxygen consumed by seeds and the effect of a cold environment on respiration. (flinnsci.com)
Occurs1
- Cancer occurs when cells no longer function normally. (nih.gov)
20211
- To summarize cases submitted to the 2021 Society for Hematopathology/European Association for Haematopathology Workshop under the categories of progression of Hodgkin lymphoma, plasmablastic myeloma, and plasma cell myeloma. (medscape.com)
Ecology1
- I have co-edited and published a number of books, the most recent being: Phytoplankton Productivity: Carbon Assimilation in Marine and Freshwater Ecosystems" (2002), "Respiration in Aquatic Ecosystems" (2005) and "Marine Ecology - Processes, Systems, and Impacts" (2005). (bangor.ac.uk)
Oxidative stress2
- 10. Cell bioenergetics in Leghorn male hepatoma cells and immortalized chicken liver cells in response to 4-hydroxy 2-nonenal-induced oxidative stress. (nih.gov)
- Similarly, the HCR heart cells were significantly more resistant to oxidative stress than LCR cells, another positive measure of mitochondrial fitness. (nih.gov)
Membrane4
- The cytoplasm is a gel-like substance, composed mostly of water, that's inside the cell membrane and outside the nucleus. (dummies.com)
- This thin membrane holds the cell together, protecting the nucleus and cytoplasm. (dummies.com)
- Dr. Hanson's group also looked at mitochondrial size and membrane potential, which can indicate the health of T cell mitochondria. (nih.gov)
- CD8 cells from people with ME/CFS showed decreased membrane potential compared to healthy cells during both resting and activated states. (nih.gov)
Extent1
- Radiosensitizers are chemical agents that have the potential to increase the lethal effect of radicals induced during irradiation [1-6].The extent of radiation damage to cells is dependent on the amount of oxygen available to the cell [1,2,7,8]. (who.int)
Biological2
Glycolysis4
- 20. Glycolysis-respiration relationships in a neuroblastoma cell line. (nih.gov)
- 9. Wortmannin influences hypoxia-inducible factor-1 alpha expression and glycolysis in esophageal carcinoma cells. (nih.gov)
- Compared to healthy cells, CD4 and CD8 cells from people with ME/CFS had decreased levels of glycolysis at rest. (nih.gov)
- In addition, ME/CFS CD8 cells had lower levels of glycolysis after activation. (nih.gov)
Hypoxic3
- Metronidazole (Flagyl) is a drug used to treat infections and has been studied in the treatment of cancer [10,11] as a radiosensitizer drug, especially for hypoxic cells [9]. (who.int)
- Metronidazole selectively radiosensitizes hypoxic cells without influencing the radiation response of normal well-oxygenated cells [5,7-9]. (who.int)
- It is worth mentioning that many of the electron-affinic radiosensitizers of hypoxic cells also have the property of preferential or selective toxicity directed against hypoxic cells even in the absence of radiation [1,2]. (who.int)
Generate1
- In the heart, the presence of mLDH could provide cardiac mitochondria with a higher capacity to generate reducing equivalents directly available for respiration, especially during exercise when circulating lactate levels are high. (nih.gov)
Hypoxia1
- 11. Hypoxia regulates the expression and localization of CCAAT/enhancer binding protein α by hypoxia inducible factor-1α in bladder transitional carcinoma cells. (nih.gov)
Skeletal1
- 5. Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity. (nih.gov)
Function5
- These cells are abnormal and do not behave or function like normal cells. (nih.gov)
- Cells are the basic unit of structure and function for all living things. (nih.gov)
- Your blood (plasma) needs to maintain a pH of 7.35 to 7.45 for your cells to function properly. (drbenkim.com)
- Cells perform various processes to function at an optimum level. (dummies.com)
- CD4 cells from healthy controls and people with ME/CFS showed no significant differences in mitochondrial size nor function. (nih.gov)
Cortical1
- Gαs regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression. (nih.gov)
Cytoplasm1
- Cytoplasm contains many chemicals that carry out the life processes in the cell. (dummies.com)
Mutations1
- These cells carry somatic mutations of the BRAF gene and/or NRAS, KRAS , and MAP2K1 genes. (medscape.com)
Reactive1
- The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear (PMN) cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. (who.int)
Types1
- The cases of Hodgkin lymphoma included transformed cases to or from various types of B-cell lymphoma with 1 exception, which had T-cell differentiation. (medscape.com)
Energy9
- What symbolizes this energy source in the "cancer cell? (nih.gov)
- Respiration is the method that all living cells use to produce energy. (educationquizzes.com)
- Whenever you see the word equation for respiration, the energy is usually shown in parentheses because it is not a substance. (educationquizzes.com)
- Energy from respiration is not used for which of the following? (educationquizzes.com)
- Energy is released from which cell organelle? (educationquizzes.com)
- Respiration is all about energy release, whereas breathing involves gaseous exchange. (educationquizzes.com)
- Also, as your cells produce energy on a continual basis, a number of different acids are formed and released into your body fluids. (drbenkim.com)
- Oxygen is the source of life and energy to all cells. (keywen.com)
- Dr. Hanson's team used state-of-the-art methods to look at energy production by the mitochondria within T cells, when the cells were in a resting state and after they had been activated. (nih.gov)
Examine2
Study1
- Simple respirometers create a respiration chamber to study respiration. (flinnsci.com)
Rate2
Stem1
- Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. (nih.gov)
Normal2
Process1
- Using live-cell imaging, they assessed the efficiency of autophagy, a process in which old or damaged organelles, including mitochondria, are cleared from a cell. (nih.gov)
Animal2
- Animal cells don't have such a structure. (dummies.com)
- Animal cells contain centrioles (cylindrical structures involved in cell division). (dummies.com)
Characteristics2
- The cells take on new characteristics that allow them to behave in an undesirable manner. (nih.gov)
- Living things are made up of cells that share certain characteristics. (dummies.com)
Healthy1
- At all ages, autophagy was significantly higher in HCR heart cells in comparison to LCR, suggesting robust maintenance of a healthy mitochondrial network in HCR heart cells. (nih.gov)
Chemical1
- Hemoglobin A chemical found in red blood cells that transports oxygen. (keywen.com)