Central Nervous System Neoplasms: Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.Nervous System Neoplasms: Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.Recurrence: The return of a sign, symptom, or disease after a remission.Fusion Proteins, bcr-abl: Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.Leukemia, Lymphoid: Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Benzamides: BENZOIC ACID amides.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Computer Communication Networks: A system containing any combination of computers, computer terminals, printers, audio or visual display devices, or telephones interconnected by telecommunications equipment or cables: used to transmit or receive information. (Random House Unabridged Dictionary, 2d ed)Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Computer Systems: Systems composed of a computer or computers, peripheral equipment, such as disks, printers, and terminals, and telecommunications capabilities.Microscopy: The use of instrumentation and techniques for visualizing material and details that cannot be seen by the unaided eye. It is usually done by enlarging images, transmitted by light or electron beams, with optical or magnetic lenses that magnify the entire image field. With scanning microscopy, images are generated by collecting output from the specimen in a point-by-point fashion, on a magnified scale, as it is scanned by a narrow beam of light or electrons, a laser, a conductive probe, or a topographical probe.Microscopy, Electron, Scanning: Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Gene Library: A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.United StatesMicroscopy, Confocal: A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Exocytosis: Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.Mast Cells: Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Membrane Fusion: The adherence and merging of cell membranes, intracellular membranes, or artificial membranes to each other or to viruses, parasites, or interstitial particles through a variety of chemical and physical processes.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Cytoplasmic Granules: Condensed areas of cellular material that may be bounded by a membrane.Chymases: A family of neutral serine proteases with CHYMOTRYPSIN-like activity. Chymases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Optics and Photonics: A specialized field of physics and engineering involved in studying the behavior and properties of light and the technology of analyzing, generating, transmitting, and manipulating ELECTROMAGNETIC RADIATION in the visible, infrared, and ultraviolet range.Neuroprotective Agents: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.Ibotenic Acid: A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.Hippocampus: A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Cell Death: The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.Dyscalculia: Impaired ability in numerical concepts. These inabilities arise as a result of primary neurological lesion, are syndromic (e.g., GERSTMANN SYNDROME ) or acquired due to brain damage.Faculty: The teaching staff and members of the administrative staff having academic rank in an educational institution.Education, Graduate: Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.Faculty, Medical: The teaching staff and members of the administrative staff having academic rank in a medical school.Faculty, Dental: The teaching staff and members of the administrative staff having academic rank in a dental school.Faculty, Nursing: The teaching staff and members of the administrative staff having academic rank in a nursing school.Students: Individuals enrolled in a school or formal educational program.Teaching: The educational process of instructing.Mentors: Senior professionals who provide guidance, direction and support to those persons desirous of improvement in academic positions, administrative positions or other career development situations.Education, Pharmacy, Graduate: Educational programs for pharmacists who have a bachelor's degree or a Doctor of Pharmacy degree entering a specific field of pharmacy. They may lead to an advanced degree.Peer Group: Group composed of associates of same species, approximately the same age, and usually of similar rank or social status.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.Videotape Recording: Recording of visual and sometimes sound signals on magnetic tape.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Peer Review: An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.Television: The transmission and reproduction of transient images of fixed or moving objects. An electronic system of transmitting such images together with sound over a wire or through space by apparatus that converts light and sound into electrical waves and reconverts them into visible light rays and audible sound. (From Webster, 3rd ed)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)

Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer. (1/97)

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PID: the Pathway Interaction Database. (2/97)

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Is cell rheology governed by nonequilibrium-to-equilibrium transition of noncovalent bonds? (3/97)

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Robustness analysis of cellular memory in an autoactivating positive feedback system. (4/97)

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Rest-mediated regulation of extracellular matrix is crucial for neural development. (5/97)

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Actin nucleation and elongation factors: mechanisms and interplay. (6/97)

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Genetic and cell biological analysis of integrin outside-in signaling. (7/97)

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Attachment of osteocyte cell processes to the bone matrix. (8/97)

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*MAP4K4

... is involved in a wide array of physiological processes including cell migration, proliferation and adhesion; its ... Multiple isoforms of MAP4K4 can be present at any given time in the same cell but the abundance of each isoform in the cell ... Deletion of the MAP4K4 gene appears to affect membrane dynamics in endothelial cells, resulting in reduced cell migration and ... processes that are highly correlated with cell migration and motility. There is limited information regarding how MAP4K4 is ...

*Bi-specific T-cell engager

This action mimics physiological processes observed during T cell attacks against tumor cells. The following BiTEs are in ... BiTEs form a link between T cells and tumor cells. This causes T cells to exert cytotoxic activity on tumor cells by producing ... One of the scFvs binds to T cells via the CD3 receptor, and the other to a tumor cell via a tumor specific molecule. Like other ... They direct a host's immune system, more specifically the T cells' cytotoxic activity, against cancer cells. BiTE is a ...

*Solitomab

This action mimics physiological processes observed during T cell attacks against tumor cells. Helwick, Caroline (1 June 2008 ... solitumab forms a link between T cells and its target tumor cell antigen. This causes T cells to exert cytotoxic activity on ... These proteins enter tumor cells and initiate the cell's apoptosis. ... "Novel BiTE antibody mediates contact between T cells and cancer cells". Oncology NEWS International. 17 (6). Clinical trial ...

*Carcinogenesis

... and epigenetic levels and abnormal cell division. Cell division is a physiological process that occurs in almost all tissues ... Cancer stem cells may arise from transformation of adult stem cells or differentiated cells within a body. These cells persist ... and stem cells are the only cells that can transmit DNA from the zygote to cells late in life. Other cells cannot keep DNA from ... Each cell has a chance of damage. Cells often die if they are damaged, through failure of a vital process or the immune system ...

*Activin type 2 receptors

They are involved in a host of physiological processes including, growth, cell differentiation, homeostasis, osteogenesis, ... These cells are responsive to both autocrine and paracrine activin B signaling, which controls their proliferation. Cells of ... Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ... ACR2A and ACVR2B was found to be localized primarily in the gonocytes as well as in sertoli cells. ...

*Activin type 1 receptors

They are involved in a host of physiological processes including, growth, cell differentiation, homeostasis, osteogenesis, ... Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ...

*Parvalbumin

Calcium binding proteins like parvalbumin play a role in many physiological processes, namely cell-cycle regulation, second ... Cell. 149 (3): 708-21. doi:10.1016/j.cell.2012.02.046. PMC 3375906 . PMID 22541439. Cowan, Ronald L.; Wilson, Charles J.; Emson ... cells, each subtype targeting distinct domains of pyramidal cells. PV interneurons' connections are mostly perisomatic (around ... and expressed predominantly by chandelier and basket cells in the cortex. In the cerebellum, PV is expressed in Purkinje cells ...

*Inositol trisphosphate receptor

... and is necessary for the control of cellular and physiological processes including cell division, cell proliferation, apoptosis ... Cell. 17 (2): 193-203. doi:10.1016/j.molcel.2004.11.047. PMID 15664189. Bosanac I, Alattia JR, Mal TK, et al. (December 2002 ... Most of the InsP3Rs are found in the cell integrated into the endoplasmic reticulum. The asymmetric structure consists of an N- ...

*Secretomics

Secreted proteins are involved in a variety of physiological processes, including cell signaling and matrix remodeling, but are ... Supernatant from cells grown in normal medium and cells grown in medium with stable-isotope labeled amino acids is mixed in a 1 ... Besides being important in normal physiological processes, secreted proteins also have an integral role in tumorigenesis ... Cancer cell line supernatant is an attractive source of secreted proteins. There are many standardized cell lines available and ...

*CTGF

Hall-Glenn F, Lyons KM (October 2011). "Roles for CCN2 in normal physiological processes". Cell. Mol. Life Sci. 68 (19): 3209- ... CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, ... promotes endothelial cell survival, and induces angiogenesis in vivo". Mol. Cell. Biol. 19 (4): 2958-66. PMC 84090 . PMID ... inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis". Mol. ...

*Satureja

This further reduces the weed's cell division and inhibits its germination, growth, and physiological processes. Satureja ...

*IFITM1

IFITM proteins are involved in the physiological process of immune response signaling, germ cell maturation and development. ... 2003). "Involvement of LEU13 in interferon-induced refractoriness of human RSa cells to cell killing by X rays". Radiat. Res. ... 1984). "Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells". Cell. 38 (3 ... Cell. 139 (7): 1243-54. doi:10.1016/j.cell.2009.12.017. PMC 2824905 . PMID 20064371. Li K, Markosyan RM, Zheng YM, Golfetto O, ...

*COQ7

Defects of the gene slow down a variety of developmental and physiological processes, including the cell cycle, embryogenesis, ... As a cofactor, ubiquinone is often involved in processes that produce reactive oxygen species (ROS). In addition, ubiquinone is ... Nature Cell Biology. 17: 782-92. doi:10.1038/ncb3170. PMC 4539581 . PMID 25961505. Maruyama K, Sugano S (1994). "Oligo-capping ... redox active lipid that is found in most cellular membranes where it acts as a cofactor in numerous cellular redox processes, ...

*Ernst Küster

... made important contributions in his research involving the physiological and chemical processes associated with plant cells. He ... "Contribution to the Process of Leaf Fall", 1967 "Pathology of the plant cell": Part 1, 1975 "Pathology of Protoplasm (Pathology ... Ernst Küster (18 June 1874 in Breslau - 6 July 1953 in Gießen) was a German botanist known for his work in plant cell research ... of the Plant Cell, Part 1)", 1996. The standard author abbreviation Küster is used to indicate this person as the author when ...

*Voltage-sensitive dye

Many physiological processes are accompanied by changes in cell membrane potential which can be detected with voltage sensitive ... Many such algorithms exist; one signal processing algorithm can be found in recent work with the ANNINE-6plus dye. Cells may be ... Potentiometric dyes are used to monitor the electrical activity inside cell organelles where it is not possible to insert an ... Potentiometric dyes: Imaging electrical activity of cell membranes. Leslie M. Loew. Pure &Appl. Chern., Vol. 68, No. 7, pp. ...

*Metamorphosis

Many observations[when?] have indicated that programmed cell death plays a considerable role during physiological processes of ... Chapter 3. Gullan, P.J. & Cranston, P.S. 6.3 Process and Control of Moulting in The Insects: An Outline of Entomology. ... Metamorphosis is a biological process by which an animal physically develops after birth or hatching, involving a conspicuous ... After metamorphosis, these organs become redundant and will be resorbed by controlled cell death, called apoptosis. The amount ...

*Tissue stress

These are cells unspecific resistance modulation and influencing the speed of physiological processes occurring in the cell. ... In the process of a slight damage of the cell the phase of metabolism stimulation is forming in it. When the cell is slightly ... Regulation of tissue cell mass by the TAS mechanism can be carried out in two physiological regimes - ether by formation of " ... Meanwhile, the cell stress concept considers only the first possibility. At the present moment, two physiological functions of ...

*State switching

... (a.k.a. phenotypic switching) is a fundamental physiological process in which a cell/organism undergoes ... iPS cells), tumor heterogeneity and emergence of cancer stem cells from non-stem cancer cells. Implicit in the MRK model, the ... or Tumour-initiating Cells. Interestingly, unlike in the case of normal cells, state switching in cancer cells is widely ... Cell 144: 910-25 (2011). van der Horst G, Bos L, van der Pluijm G. Epithelial plasticity, cancer stem cells, and the tumor- ...

*Prostaglandin DP2 receptor

The process, termed Homologous desensitization, serves as a physiological limiter of cell responses to DP2 activators. Ligands ... an increase in the expression of DP2 by these cells, an enhanced rate of differentiation of precursor cells to Th2 cells in ... cell cycle genes in fetal testes which contribute to the arrest of mitotic process and to the differentiate of germ cells. This ... see T helper cell#Th1/Th2 Model for helper T cells) by binding to a receptor initially termed GPR44 and thereafter CRTH2 (for ...

*Arsenic poisoning

The interference of oxidative stress with signal transduction pathways may affect physiological processes associated with cell ... This is consistent with observed ATP depletion of exposed cells and histopathological findings of mitochondrial and cell ... "Effects of arsenic trioxide on voltage-dependent potassium channels and on cell proliferation of human multiple myeloma cells ... However, high levels of inorganic arsenic inhibit NF-κB activation and cell proliferation. An experiment of Hu et al. (2002) ...

*Equilibrative nucleoside transporter family

... mammalian ENTs additionally influence physiological processes ranging from cardiovascular activity to neurotransmission. The ... By regulating the concentration of adenosine available to cell surface receptors, ...

*Hypercomplex cell

Orban, G. (2008). Higher order visual processing in macaque extrastriate cortex. Physiological Reviews, 88, 59-89.. ... Akin to simple cells, complex cell receptive fields are orientation selective. However, unlike simple cells, complex cells do ... "all cells that exceed complex cells in intricacy of behavior." Hypercomplex cells displayed selectivity akin to complex cells, ... A hypercomplex cell (currently called an end-stopped cell) is a type of visual processing neuron in the mammalian cerebral ...

*Roberto Kolter

... formation was unexplored and most microbiologists did not view biofilm formation as a physiological process of bacterial cells ... van Gestel, Jordi; Vlamakis, Hera; Kolter, Roberto (2015-04-20). "From Cell Differentiation to Cell Collectives: Bacillus ... Cell. 1996 Jul 26;86(2):181-4. In the 1990s, Kolter's group became interested in the genetic pathways of surface-associated ... Cell. 1978 Dec;15(4):1199-208. Kolter R, Helinski DR. Plasmid R6K DNA replication. II. Direct nucleotide sequence repeats are ...

*Novus Scientific

... a process known as "mechanotransduction", which is the physiological process by which cells sense and respond to mechanical ...

*Bruce J. Tromberg

... has used non-linear optical microscopy for high resolution functional mapping of physiological processes in living cells and ... Among his most important papers are: Zoumi, A. Yeh, A. Tromberg, B.J. Imaging Cells And Extracellular Matrix In Vivo Using ... Zoumi, A.; Yeh, A.; Tromberg, B. J. (12 August 2002). "Imaging cells and extracellular matrix in vivo by using second-harmonic ... detection of physiological changes, and photodynamic therapy. Tromberg is interested in developing non-invasive methods for in ...

*Jesse Francis McClendon

... life processes of cell membranes, the importance of pH control, the role of iodine in human health, and specifically its ... 1914-1939: McClendon worked at Physiological Laboratory of the University of Minnesota Medical School, Minneapolis (1920-1939- ... he was Professor of Physiological Chemistry). In the Laboratory McClendon realized some pioneer researches, including low ...
Cells, either as unicellular organisms or as part of a tissue of a multicellular organism, can acquire different functions thanks to their capability of changing their expression state. The enzyme synthesis, cell division or cell differentiation are some examples of these functions. The turning on and off of them lie in the mechanisms by which cells are able to integrate the information they perceive from the environment. Frequently, cells exhibit different responses under the same stimulus or environment. These probabilistic processes, whose behaviours are not univocal, are known as "cellular decision making". We can classify these processes according to the range at which the decision is made. We denominate cell-autonomous decision those in which of each cell chooses its response independently of the choice of the other cells of the population. By contrast, if the decision is made collectively by the whole population, it is classified as non autonomous. This second type of decisions involve ...
Many cellular processes require decision making mechanisms, which must act reliably even in the unavoidable presence of substantial amounts of noise. However, the multistable genetic switches that underlie most decision-making processes are dominated by fluctuations that can induce random jumps between alternative cellular states. Here we show, via theoretical modeling of a population of noise-driven bistable genetic switches, that reliable timing of decision-making processes can be accomplished for large enough population sizes, as long as cells are globally coupled by chemical means. In the light of these results, we conjecture that cell proliferation, in the presence of cell-cell communication, could provide a mechanism for reliable decision making in the presence of noise, by triggering cellular transitions only when the whole cell population reaches a certain size. In other words, the summation performed by the cell population would average out the noise and reduce its detrimental impact ...
Objective: We investigated the association of anti-inflammatory cytokines interleukin-1 receptor antagonist (IL-1ra) and adiponectin as well as pro-inflammatory cytokines IL-1β, IL-6, CCL2 and tumor necrosis factor (TNF)-α with β-cell function, metabolic status and clinical remission in patients with recent onset type 1 diabetes.. Research Design and Methods: Serum was obtained from 256 newly diagnosed patients (122 males/134 females, median age 9.6 years). Stimulated C-peptide, blood glucose and HbA1c were determined in addition to circulating concentration of cytokines at one, six and twelve months after diagnosis. Analyses were adjusted for sex, age and BMI percentiles.. Results: Anti-inflammatory IL-1ra was positively associated with C-peptide after six (p=0.0009) and twelve months (p=0.009). The beneficial association of IL-1ra on β-cell function was complemented by the negative association of IL-1β with C-peptide after one month (p=0.009). In contrast, anti-inflammatory adiponectin ...
The folding state of polypeptides is easily perturbed by adverse conditions. Misfolded proteins are non-functional and lead to a measure of inefficiency in the cells economy. Their presence has additional consequences that are unrelated to loss-of-function features as numerous genetic and biochemical observations suggest that structures elaborated by polypeptides that fail to attain their proper three dimensional structure have deleterious gain-of-function effects on cell function. This process, also referred to as proteotoxicity, appears to be particularly important to the fate of non-renewable cells of long-lived organisms in which accumulating misfolded proteins can act over extended periods of time. The hypothesized contribution of such proteotoxins to cellular dysfunction fits our intuitive notions of aging as a time and use-dependent process. The progressive aging of the human population has led to an increase in the incidence of diseases hypothesized to be associated with various ...
Can Vitamin D Benefit Patients with Prediabetes? No Effect of High-Dose Vitamin D Treatment on β-Cell Function, Insulin Sensitivity, or Glucose Homeostasis in Subjects With Abnormal Glucose Tolerance: A Randomized Clinical Trial Henrik Wagner1⇑, Michael Alvarsson1, Buster Mannheimer2, Marie Degerblad1 and Claes Göran Östenson1 http://care.diabetesjournals.org/content/early/2016/01/07/dc15 -1057.abstract Abstract OBJECTIVE There has been conflicting evidence regarding the potential role of vitamin D in glucose homeostasis. This study was designed to investigate the effect of high-dose vitamin D3 treatment on β-cell function, insulin sensitivity, and glucose tolerance in subjects with prediabetes or … Continue reading →. ...
Copyright in the material you requested is held by the American Society of Mechanical Engineers (unless otherwise noted). This email ability is provided as a courtesy, and by using it you agree that you are requesting the material solely for personal, non-commercial use, and that it is subject to the American Society of Mechanical Engineers Terms of Use. The information provided in order to email this topic will not be used to send unsolicited email, nor will it be furnished to third parties. Please refer to the American Society of Mechanical Engineers Privacy Policy for further information ...
This message is to announce the creation of a new WWW resource deidicated to spreading information regarding the study of chromatin structure, with emphasis on the proteins that modify chromatin structure, and the effects that these modifications have on cell function. Please view this site frequently, because the field is evolving rapidly, and so the website is updated quite often. If you have any suggestions or announcements that you wish posted (Job openings, meetings, etc) my email address is included as part of the page, so feel free to contact me. Thanks, Jim bone Chromatin Structure and Function Page http://rampages.onramp.net/~jrbone/chrom.html ----------------------------------------------------------------------------- James R. Bone Dept. of Biochemistry and Molecular Biology M. D. Anderson Cancer Center, Box 117 1515 Holcombe Avenue Houston, TX 77030 email:jrbone at odin.mdacc.tmc.edu :jrbone at onramp.net voice: 713-792-2549 Roth Lab Homepage-- ...
We have shown that near-total α-cell loss in adult mice has little effect on glucagonemia and no apparent effect on β-cell function or glucose homeostasis. This reveals that 2 to 4% of the normal α-cell mass is astonishingly sufficient to produce enough glucagon to ensure glycemic control under basal conditions. Massive α-cell loss is associated with a rapid enhancement of glucagon sensitivity, which allows increased glucose mobilization, even if the decrease in glucagonemia is very mild.. A corollary of this observation is that the normal amount of pancreatic α-cells apparently exceeds the physiologic requirement for proper blood glucose homeostasis. Indeed, the total glucagon found in the pancreas when only 2% of the α-cells remain was sufficient to maintain normoglucagonemia. A simple calculation reveals that if all pancreatic glucagon found 1 week after α-cell loss (∼7,400 pg; Supplementary Table 2) were entirely released at once into the circulation, glucagonemia would be more than ...
I take glandular supplements about one month. In the beginning i consume only adrenal, thymus and orchic ones in the different products. But the result not so expressive as this product gave me. I think this because of spleen and pancreas tissues maybe. The spleen takes very important role in a growth of lymphocytes. And it takes to be proved this taking spleen glands supplement separately. And of course this product is highly recommended! ...
Cellular Physiology and Biochemistry is a multidisciplinary scientific forum dedicated to advancing the frontiers of basic cellular research. It addresses scientists from both the physiological and bi
Alteration in charge means the membrane acts as a capacitor, with most cells having a resting potential 70-80mV lower than extracellular ...
As indicated above, renin cells communicate with one another and with adjacent cells, including smooth muscle, mesangial cells, and perivascular interstitial cells. Disruption of such communication alters the renin phenotype, demonstrating that the identity of these cells is heavily dependent on the cells context, particularly their interaction with other cell types.. The Notch pathway is an ancestral, highly conserved, cell-to-cell communication system involved in cell fate decisions during development and in response to physiological challenges.54,55 Notch receptors, their ligands, and their final transcriptional effector, RBP-J, are expressed in renin cells.32 We found that the disruption of the Notch pathway either by the inhibition of γ-secretase (unpublished) or conditional deletion of RBP-J in renin cells56 results in severe reduction in the number of renin cells, low circulating renin, and decreased blood pressure. Further, mutant mice are unable to recruit renin cells in response to a ...
Engineering quantum science into quantum reality 16 April 2015 The University of Bristol has today launched its new state-of-the-art Quantum Engineering Technology (QET) Labs. The QET Labs will provide unique world-leading facilities, bringing together industrial and academic collaborators to build devices that span numerous areas of quantum technology development from the nano-fabrication of quantum devices to a city-scale Quantum Key Distribution network. ...
Genetics is a powerful tool, especially when used in combination with embryology, in the seeking of genes necessary for assembly of the cardiovasculature. The first questions must address the types of cellular decisions that are made during development. As for simpler systems in C elegans and D melanogaster, the lineage and cell-fate decisions of the cardiovascular progenitors need to be assessed. In addition it is likely that new paradigms will emerge for multicellular assembly. The study of cardiovascular mutations will define individual genetic steps that define organotypic decisions. A genetic approach is a natural extension of embryology, physiology, and anatomy, fields of great sophistication with regard to the cardiovasculature, because, like them, it focuses on integrative biology and on the intact organism. The zebrafish is particularly well suited to a combination genetic-embryologic study of the fashioning of the cardiovasculature. ...
Expression of CDK11A (CDC2L2, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, p58GTA, PITSLRE) in pancreas tissue. Antibody staining with HPA025061 and CAB010467 in immunohistochemistry.
Expression of ACSBG2 (BGR, DKFZp434K1635, PRTD-NY3) in pancreas tissue. Antibody staining with HPA043421 and HPA051013 in immunohistochemistry.
My research interests include Bacterial Cell Cycle Regulation and Signal Transduction mechanisms.. 1. Bacterial Cell Cycle Regulation- Epigenetic mechanisms regulating various physiological activities in the prokaryotic cells are increasingly being appreciated. Methylation of specific bases of the DNA molecule by methyltransferases is the most common epigenetic modification observed in the bacterial cells. This modification of nucleotides adds another level of regulation at the transcription; furthermore, it has a fundamental role in the cell physiological processes such as DNA replication, DNA mismatch repair, and virulence mechanisms in many pathogens. Among the prokaryotic DNA methyltransferases, Dam expressed among the Gammaproteobacteria is the most intensively studied. In contrast to Dam, another DNA methyltransferase CcrM (Cell Cycle Regulated Methylase) has been described in the Alphaproteobacteria, where it plays an important role in the cell cycle regulation of Caulobacter crescentus ...
From previous studies, it is known that the low OA risk haplogroup J is associated with lower serum levels of markers of collagen type-II degradation and of matrix metalloproteinases, but all of these studies failed to address the key question arising from this large body of evidence: What is the functional role of these mtDNA haplogroups?. To answer this question, Fernandez-Moreno et al7 used cytoplasmic hybrid (cybrid) cell lines. Cybrids incorporate mitochondria from human subjects and perpetuate the mtDNA-encoded components while maintaining the nuclear background of different cybrid lines as constant.16 Thus, this technique allows investigators to assess the influence of mtDNA variation on cell function. To investigate the role of mtDNA haplogroups, they also created cybrids using osteosarcoma cell lines with the same nuclear background, one of them harbouring the haplogroup J (which protects against OA) and another harbouring the haplogroup H (linked to higher risk of OA).. The cybrids ...
Sigma Zeta 2014 Fall Banquet:. On Tuesday, November 4th our own Dr. Nathan Lindquist from the physics department spoke on "Interdisciplinary nanotechnology research: the science and its many applications." Over the past few years, Bethel has invested in building a "NanoLab" for interdisciplinary student/faculty research on microscopy, spectroscopy, imaging, bio-sensing, nano-fabrication and nano-characterization. The recent addition of a Scanning Electron Microscope further builds our potential for cutting-edge projects. The talk provided some background on the science of nanotechnology, the tools of the trade, and its many promising applications. We found out how nano-research is directly aimed at solving some of our biggest challenges in energy, healthcare, and the environment. As is our custom in the fall, our banquet is a combined event with members of the Minnesota Microscopy Society. We had a total of 48 in attendance including students, faculty and MMS members. We recognized new members ...
Cellular decisions to live or die are fundamental to development and adult homeostasis, playing roles in a wide variety of physiological and pathological processes. These include cancer, degenerative disease, innate and adaptive immunity, ischemia-reperfusion injury, and infectious disease. As the study of cell death moves beyond the central mechanisms of apoptosis to wider issues of regulation and other forms of cell death, this vibrant area of research widens its influence and importance for human health and disease.
Pancreatic cancer begins in pancreas tissues. Pancreas lies in the abdomen just behind the lower part of the stomach. These secrete enzymes which help in digestion and hormones which help in regulating sugar metabolism. Often, pancreatic cancer has a poor prognosis even it is diagnosed early. Typically, it spreads rapidly. It is rarely detected in the initial stage. This is the major reason for many pancreatic cancer deaths. Symptoms do not develop till the cancer reaches advanced stage and it is not possible to remove it surgically. Pancreatic Cancer Causes: ...
The Food and Drug Administration is looking into new evidence that suggests a group of recently approved diabetes drugs can increase the risk of pancreatitis and other problems. The agency said Thursday samples of pancreas tissue taken from a small number of patients showed inflammation and cellular changes that often precede cancer. Academic researchers took the samples from diabetes patients who were taking the new medications, after they died from various causes.
A new class of viologen-phosphorus dendrimers (VPDs) has been recently shown to possess the ability to inhibit neurodegenerative processes in vitro. Nevertheless, in the Central Nervous Systems domain, there is little information on their impact on cell functions, especially on neuronal cells. In this work, we examined the influence of two VPD (VPD1 and VPD3) of zero generation (G0) on murine hippocampal cell line (named mHippoE-18). Extended analyses of cell responses to these nanomolecules comprised cytotoxicity test, reactive oxygen species (ROS) generation studies, mitochondrial membrane potential (ΔΨm) assay, cell death detection, cell morphology assessment, cell cycle studies, as well as measurements of catalase (CAT) activity and glutathione (GSH) level. The results indicate that VPD1 is more toxic than VPD3. However, these two tested dendrimers did not cause a strong cellular response, and induced a low level of apoptosis. Interestingly, VPD1 and VPD3 treatment led to a small decline in ROS
Philip Calder is Professor of Nutritional Immunology at the University of Southampton, UK. He has a first class honours degree in biochemistry from Massey University, New Zealand, a PhD in biochemistry from the University of Auckland, New Zealand, and a DPhil in biochemistry from the University of Oxford, UK. He held a Nuffield Medical Fellowship in the Department of Biochemistry, University of Oxford from 1987 to 1991. Professor Calder has been studying the influence of dietary fatty acids on aspects on cell function and human health, in particular in relation to cardiovascular disease, inflammation and immunity, since 1987. In 1995 he was awarded the Sir David Cuthbertson Medal by the UK Nutrition Society for this work and he has been awarded the Belgian Danone Institute Chair for 2004, the Nutricia International Award for 2007, the ESPEN Cuthbertson Lecture for 2008, and the Muriel Bell Award for 2009. Professor Calder served as an elected member of the Council of the UK Nutrition Society and ...
The MRC laboratories reach users from many different fields: electronics, optics, physics, chemistry, astronomy, as well as chemical, mechanical, and petroleum engineering. Lab users are both from universities and corporates. UT MRC is more than a cleanroom with open-access with a comprehensive set of nano-fabrication equipment - it is a community of scientists who works together to build advanced technology products and knowledge.. ...
Modeling of phenomena observed in biological systems and the search for underlying mechanisms and principles have a long history, with remarkable contributions from Mathematical Biology. The development of the Hodgkin-Huxley model as an explanation of the temporal behavior of excited neurons or the class of predator-prey models for describing the dynamics of competing populations are prominent examples. Their principles can still be found in many areas of research (see e.g. Chapter 2 in [3] or Chapter 3 in [4]). Moreover, although classical Cell Biology was in the past a predominantly reductionist approach, in which cells were broken down into small subsystems, this was always accompanied by models on the system level. Regulation processes that drive cellular decisions, such as the lytic and lysogenic pathway in bacteriophage lambda [5, 6], the diauxic switch between glucose and lactose uptake in bacterial cells [7] or apoptotic decision processes [8], have been in the focus of interest for a ...
In the 1860s, the German scientist Paul Langerhans discovered tiny patches of cells in cross-sections of pancreas tissues. They looked like little islands, hence their name - islets of Langerhans. These islets have a rich blood supply and consist of two type of cells - larger alpha cells and numerous smaller beta cells. The function of these islets were unknown until the 20th century when scientists found that removing the pancreas for an animal resulted in a disease similar to human diabetes (incidentally, dogs and cats can get diabetes too).. It was isolated in the 1920s by Banting, Best & MacLeod in Canada.. Animals with their pancreas removed were treated with the "insulin" (meaning island), and this cured the animals of the diabetes. Animal insulin was then successfully used to treat humans for many years before genetic engineering took over the production.. ...
Each cell division, the nuclear DNA must be replicated efficiently and with high accuracy to avoid mutations which can have an effect on cell function. There are three replicative DNA polymerases essential for the synthesis of DNA during replication in eukaryotic cells. DNA polymerase α (Pol α) synthesize short primers required for DNA polymerase δ (Pol δ) and DNA polymerase ε (Pol ε) to carry out the bulk synthesis. The role of Pol δ and Pol ε at the replication fork has been unclear. The aim of this thesis was to examine what role Pol ε has at the replication fork, compare the biochemical properties of Pol δ and Pol ε, and to study the function of the second largest and essential subunit of Pol ε, Dpb2.. To identify where Pol ε replicates DNA in vivo, a strategy was taken where the active site of Pol ε was altered to create a mutator polymerase leaving a unique error-signature. A series of mutant pol ε proteins were purified and analyzed for enzyme activity and fidelity of DNA ...
The book covers areas of cellular physiology and metabolism that are of interest to scientists involved in research in diabetes and metabolic diseases. Some chapters of the book are specifically research-oriented, as all the authors are actively practicing either bench or clinical research in the
Hyperglucagonemia is an important factor for type 2 diabetes which contributes to increased hepatic glucose production (Rizza 2010). In spite of this, however, little is known about the role of chronically elevated glucagon levels for β-cell function. A reason for this is the lack of appropriate models of long-term glucagon action, which in part is due to difficulties in administering native glucagon long-term because of poor chemical and physical stability. Therefore, in the current study, we administered a stable glucagon analog (ZP-GA-1) to mice fed a HFD to create a novel model for studying effects of chronic GCGR activation on β-cell function. The HFD fed mice do not develop hyperglucagonemia (Ahlkvist et al. 2013) which allowed us to study the impact of chronic GCGR stimulation on glucose tolerance in a glucose intolerant model without the confounding factor of endogenous hyperglucagonemia. In these mice, 2-week ZP-GA-1 infusion markedly reduced the insulin response to oral glucose. ...
The project would include but not be limited to applications of single molecule spectroscopy to understanding of protein folding reactions. Candidates should have a recent Ph.D. in engineering, chemistry, physics, materials science or a related field. The work will involve design, fabrication & characterization of the microfluidics devices and their applications. The candidate would have access to research facilities at both at Center for Biophotonics S&T at UC Davis and at Lawrence Livermore National Laboratory. Opportunities also exist for close collaboration with Single Molecule Biophysics Group at UCLA http://smb.chem.ucla.edu/ and with the laboratory of Prof. L. Lapidus at Michigan State (http://www.pa.msu.edu/~lapidus/introduction.htm). Experience in as many of the following disciplines is not necessary but it would be a plus: computational fluid dynamics, micro- and nano-fabrication, microfluidics, fluorescence microscopy. The ideal candidate would be a person with experience in one of ...
As a result, Dr. Waldman notes, the findings also indicate that these miRNAs can serve as diagnostic markers. "Because they are involved in processes underlying cancer, these specific miRNAs mediate the disease process in different types of cells, such as pancreas or lung, for example," he says. "There apparently is a profile of miRNAs that identify pancreatic cancer cells from other types. It appears that in some cases, there are common miRNAs, and for others there are miRNAs that can distinguish different types of cancer. A tumor can be profiled based on miRNAs." MiRNAs cans serve as prognostic markers as well. "They apparently distinguish normal pancreas tissue from inflamed tissue from cancer, and this paper shows miRNAs correlate with who will do well and who wont," Dr. Waldman explains. "Presumably, it follows that miRNAs could be predictive markers, which could have implications for therapy. "On top of this, there is a new layer of biology that is identifying novel mechanisms involved in ...
Background : Carcinoma of the pancreas is a fatal malignant disease with limited therapeutic options. Cyclooxygenase-2 (COX-2) and c-erbB-2 are known to be involved in the carcinogenesis, differentiation and invasiveness of various neoplasms. We studied the immunohistochemical expressions of c-erbB-2 and COX-2 and the correlation between these expressions and the clinicopathologic parameters and the relation between the expressions. Methods : Immunohistochemical staining for c-erbB-2 and COX-2 were performed on the paraffin embedded sections of 36 cases of surgically resected ductal adenocarcinoma of the pancreas and 10 cases of non-neoplastic pancreas tissue. Results : The non-neoplastic control group showed a c-erbB-2 expression in the acini (8/10) and ducts (2/10), and a COX-2 expression in the acini (6/10) and ducts (3/10). The overexpression of c-erbB-2 was observed in 58% (21/36) of the carcinoma specimens. No significant correlation was found between c-erbB-2 and age, gender, tumor size, ...
Synthetic Biology. 6. Synthetic Biology. What is Synthetic Biology?. Discover Magazine: Scientists of the Year. Undergraduates in Synthetic Bio. international Genetically Engineered Machines. http://parts.mit.edu/registry/index.php/Main_Page. 37 Teams in 2006; 57 in 2007. Slideshow 65399 by mike_john
Ensuring benefits of synthetic biology are realized through responsible development. Synthetic biology specific news, events, publications and more.
Synthetic biology is a new field where basic biological components can be engineered to create something new. It often involves DNA synthesizers, ligation, promoters, and polymerase chain reaction -- which may or may not be safe for your in silico environment. However, as the size and complexity of the systems increase, tools become more and more important, thus CAD for biology has emerged.. ...
Synthetic Biology Market report analyzes the synthetic biology market and aims at estimating the market size and growth potential of this market based on various aspects such as tools, technologies, applications, and regions.
Ensuring benefits of synthetic biology are realized through responsible development. Synthetic biology specific news, events, publications and more.
A 2013 survey conducted by the Woodrow Wilson Synthetic Biology Project found that 75% of adults have heard just a little or nothing at all about synthetic biology, figures that were virtuall
The global Synthetic Biology Market is fuelled by extensive research in DNA sequencing and rising governmental support. The growing importance of synthetic
Via this page, we hope to maintain a collection of links to online tools that are related to Synthetic Biology. If you are editing this page, please try to keep the tools in alphabectial order, by tool name. ...
Nectins and Nectin-like molecules (Necl) are families of cellular adhesion molecules involved in Ca2+-independent cellular adhesion. Nectins are ubiquitously expressed and have adhesive roles in a wide range of tissues such as the adherens junction of epithelia or the chemical synapse of the neuronal tissue. So far four nectins have been identified in humans, namely nectin-1, nectin-2, nectin-3 and nectin-4. These four family members have also been found in most other well studied mammals. Also, five Necls have been identified, these are: Necl-1, Necl-2, Necl-3, Necl-4 and Necl-5. All nectins and all Necls share the same overall structure defined by three extra cellular immunoglobulin domains, a single transmembrane helix and an intracellular domain. For all nectins the intracellular domain can bind a scaffold protein named afadin (the product of the MLLT4 gene). All nectins and Necls can form homo-cis dimers, meaning a dimer of two alike molecules on the same cell membrane. Following the ...
Molecular Biology services that, through biotechnology and systems biology, will help further our ability to create new opportunities in synthetic biology
You know the world is truly advanced when someone has invented a synthetic cell. And this happened five years ago. Enter the field of synthetic biology, defined as the use of molecular biology tools and techniques to construct genetic systems that produce a desired behavior. With the decreasing price of DNA sequencing and synthesis, the ease of genetic…
A recent survey of 3,000 people worldwide found what many have known all along-that Legos are the best toy ever made. For synthetic biologists, this doesnt come as much of a surprise-Legos are at the heart of the concepts underlying the basics of synthetic biology. Legos are a favorite analogy for BioBricks, the DNA parts…. ...
Links to various press articles about Synthetic Biology. Note that this is not a comprehensive list. ,wikionly,Please add new press articles here.,/wikionly, ...
The primary research interest of the Laboratory of Cellular Physiology, led by Dr. Lois Greene, is in the formation and breakdown of normal and pathological protein complexes in the cell, with an emphasis on the role of molecular chaperones ...
The final goal is the construction of a vesicular system that contain the minimal and sufficient number of genes and other components to be defined as living (self-sustaining + self-reproduction + evolvability). The main researchers in this filed are Pasquale Stano and Giovanni Murtas, as well as Yutetsu Kumura from the Tokyo University (from the group of prof. Ueda, with whom we are collaborating).. ...
Report HighlightsThe global synthetic-biology market reached nearly $3.9 billion in 2016 and should reach $11.4 billion by 2021, growing at a compound annual growth ...
View the latest weather forecasts, maps, news and alerts on Yahoo Weather. Find local weather forecasts for Vercheres, Canada throughout the world

MAP Kinase Signaling System | Profiles RNSMAP Kinase Signaling System | Profiles RNS

Cell Physiological Phenomena [G04]. *Cell Physiological Processes [G04.299]. *Signal Transduction [G04.299.880] ... A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens. J Clin Invest. 2017 May 01; 127(5):1651-1663. ... PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2 ... Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging. Nat Commun. 2016 Feb 12; 7:10666. ...
more infohttps://profiles.umassmed.edu/display/105851

Mst1r - Macrophage-stimulating protein receptor precursor - Mus musculus (Mouse) - Mst1r gene & proteinMst1r - Macrophage-stimulating protein receptor precursor - Mus musculus (Mouse) - Mst1r gene & protein

Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than ... Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites ... RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at ... Regulates many physiological processes including cell survival, migration and differentiation. ...
more infohttps://www.uniprot.org/uniprot/Q62190

Identification of yeast transcriptional regulation networks using multivariate random forests.  - PubMed - NCBIIdentification of yeast transcriptional regulation networks using multivariate random forests. - PubMed - NCBI

We apply our method to several yeast physiological processes: cell cycle, sporulation, and various stress conditions. Our ... which we confirm using data from two independent cell cycle studies and two other physioloigical processes. Finally, we have ... Comparisons of RC6 and RC20 uncovered in yeast cell cycle data by Cho et al. using both motifs and TF-binding as predictors. ... RC diagram of the cell cycle data by Cho et al. using both motifs and TF-binding as predictors. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/19543377

Filament rigidity and connectivity tune the deformation modes of active biopolymer networks | PNASFilament rigidity and connectivity tune the deformation modes of active biopolymer networks | PNAS

Living cells spontaneously change their shape in physiological processes like cell migration and division. Forces generated by ... Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert ... These results have implications for how conserved molecular mechanisms give rise to diverse morphogenic events in cells. ...
more infohttp://www.pnas.org/content/114/47/E10037

Molecular and clinical aspects of apoptosis.  - PubMed - NCBIMolecular and clinical aspects of apoptosis. - PubMed - NCBI

Unwanted cells are removed by physiological cell death processes that are highly conserved throughout the animal kingdom. ... Physiological cell death plays an important role in development, tissue homeostasis and defence against viral infection and ... This review describes the molecular components that implement this process, the relevance of these to a variety of human ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/8981570?dopt=Abstract

Repositorio Salud Andalucía: Clinical characteristics of patients with central nervous system relapse in BCR-ABL1-positive...Repositorio Salud Andalucía: Clinical characteristics of patients with central nervous system relapse in BCR-ABL1-positive...

Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Clonal Evolution ... Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation. Medical Subject Headings:: ... Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes:: ... blast cells. A total of 128 patients were analyzed in two PETHEMA clinical trials. All achieved complete remission after ...
more infohttps://www.repositoriosalud.es/handle/10668/2672

Plus itPlus it

Calcium ions are important second messengers governing numerous physiological processes within cells (Blaustein, 1988; Ghosh ... Nuclear staining with PI indicates cell death, because it is linearly related to the degree of cell loss (Fig. 1 B) gauged by ... 1986) Ischemic CA1 pyramidal cell loss is prevented by preischemic colchicine destruction of dentate granule cells. Brain Res ... although the many physiological effects of Ca2+ buffers on both presynaptic and postsynaptic Ca2+-dependent processes are ...
more infohttp://www.jneurosci.org/content/17/10/3538

Links - Indiana University - The Biocomplexity InstituteLinks - Indiana University - The Biocomplexity Institute

The National Resource for Cell Analysis and Modeling "NRCAM is developing methods for modeling cell physiological processes in ... NRCAM has developed a general computational tool, the Virtual Cell for modeling cell biological processes. This new technology ... Approaches in computational cell biology are coupled with high resolution light microscopy to facilitate the interplay between ... by and for developmental physiologists and developmental physiology students studying the ontogeny of physiological processes ...
more infohttp://biocomplexity.indiana.edu/res/links.php?p=res

World-Wide Web Virtual Library: MicroscopyWorld-Wide Web Virtual Library: Microscopy

The National Resource for Cell Analysis and Modeling (NRCAM) - modeling of cell physiological processes in within the three ... Improvision - Openlab cell-imaging and analysis software *List of Image Processing Web Sites from ICIP-95 *MacPhase 2.0 * ... Journey Into The Cell - a history of the first picture of an intact cell taken with an electron microscope *Locating Atoms with ... Image Processing Web sites around the World *Image Tool *Imaging Primer - A demo version of an image processing application ...
more infohttp://www.ou.edu/research/electron/www-vl/long.shtml

Cell Differentiation | Profiles RNSCell Differentiation | Profiles RNS

Below are MeSH descriptors whose meaning is related to "Cell Differentiation".. *Cell Physiological Processes ... Roles of p53 and ASF1A in the Reprogramming of Sheep Kidney Cells to Pluripotent Cells. Cell Reprogram. 2015 Dec; 17(6):441-52. ... Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell Stem Cell. ... Mesenchymal stem cell characteristics of human anterior cruciate ligament outgrowth cells. Tissue Eng Part A. 2011 May; 17(9-10 ...
more infohttps://uams-triprofiles.uams.edu/profiles/display/101784

MAP Kinase Signaling System | Profiles RNSMAP Kinase Signaling System | Profiles RNS

Cell Physiological Phenomena [G04]. *Cell Physiological Processes [G04.299]. *Signal Transduction [G04.299.880] ... An optimized protocol to quantify signaling in human transitional B cells by phospho flow cytometry. J Immunol Methods. 2018 12 ... MAPK signaling pathways and HDAC3 activity are disrupted during differentiation of emerin-null myogenic progenitor cells. Dis ...
more infohttps://profiles.uchicago.edu/profiles/display/31604

Exocytosis | Profiles RNSExocytosis | Profiles RNS

Cell Physiological Processes [G04.299]. *Exocytosis [G04.299.490]. Below are MeSH descriptors whose meaning is related to " ... Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE. ... Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L823-42. ... granule swelling during exocytosis of beige mouse mast cells. ...
more infohttps://profiles.rush.edu/display/27085

Epithelial-Mesenchymal Transition | Profiles RNSEpithelial-Mesenchymal Transition | Profiles RNS

Cell Physiological Processes [G04.299]. *Cell Transdifferentiation [G04.299.335]. *Epithelial-Mesenchymal Transition [G04.299. ... Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental ... PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer. J Biol Chem. 2015 May 22; 290(21 ... processes such as NEURAL TUBE development. NEOPLASM METASTASIS and DISEASE PROGRESSION may also induce this transition. ...
more infohttps://profiles.rush.edu/display/8112

Bcl-xL Blocking Peptide, UniProt ID Q07817 #1225 to Apaf-1 (D7G4) Rabbit mAb, UniProt ID O14727 #8723 from Cell Signaling...Bcl-xL Blocking Peptide, UniProt ID Q07817 #1225 to Apaf-1 (D7G4) Rabbit mAb, UniProt ID O14727 #8723 from Cell Signaling...

Cell Extract Kit - Caspase-3 Control Cell Extracts - Western Blotting - 100 µl #9663, Cell Extract Kit - Jurkat Apoptosis Cell ... Background: Apoptosis is a regulated physiological process leading to cell death. Caspases, a family of cysteine acid proteases ... Background: Apoptosis is a regulated physiological process leading to cell death. Caspases, a family of cysteine acid proteases ... Apoptosis Cell Extracts (Jurkat Untreated): Total cell extracts from Jurkat cells serve as a negative control. Supplied in SDS ...
more infohttps://www.cellsignal.com/1/1/indexf10.html

Gtdap-1 promotes autophagy and is required for planarian remodeling during regeneration and starvation | PNASGtdap-1 promotes autophagy and is required for planarian remodeling during regeneration and starvation | PNAS

Autophagy is a physiological process during which cells turn over organelles and proteins. It has a homeostatic role but is ... the one in the left is a normal differentiated cell, and the one on the right is a cell positive for Gtdap-1 in a process of ... of all neoblast-like cells (including determined neoblasts and cells in a process of differentiation where the nucleus/ ... This would also be consistent with the morphology of the cells as large differentiated cells in the parenchyma and cells from ...
more infohttps://www.pnas.org/content/104/33/13373

Should I go on a detox? We find out.Should I go on a detox? We find out.

Internal sources include the by-products from usual physiological processes and cells waste products. The process of breaking ... And the third facilitates transport of the converted products out of the cells, then out of the body via the bile and faeces, ... Detoxification is a three-step process. In the first two phases, fat-soluble compounds are converted to water-soluble compounds ... as well as alcohol and additives in processed foods. Then theres medication, tobacco smoke and exposure to environmental ...
more infohttps://www.mamamia.com.au/should-i-go-on-a-detox/

Genes  | Free Full-Text | Genome-Wide Identification and Characterization of Xyloglucan Endotransglycosylase/Hydrolase in...Genes | Free Full-Text | Genome-Wide Identification and Characterization of Xyloglucan Endotransglycosylase/Hydrolase in...

... is a cell-wall-modifying enzyme participating in diverse cell morphogenetic processes and adaptation to stress. In this study, ... participates in diverse physiological processes, especially cell elongation and stress resistance [6]. XTH is a cell-wall- ... is a cell-wall-modifying enzyme participating in diverse cell morphogenetic processes and adaptation to stress. In this study, ... Article Processing Charges Open Access Policy Institutional Open Access Program Editorial Process English Editing Service MDPI ...
more infohttps://www.mdpi.com/2073-4425/10/7/537/htm

Cristina Montagna, Ph.D. | Albert Einstein College of MedicineCristina Montagna, Ph.D. | Albert Einstein College of Medicine

2008). "Cell fusion is a physiological process in mouse liver." Hepatology 48(5): 1655-1664. ... and is considered a physiological process. Aneuploidy on the contrary is linked to pathological states. It is a hallmark of ... We are currently studying how the expression of various Sept9 isoforms is regulated in normal and cancer cells and the ... We have selected various candidates that we are currently investigating for their role in determining cell fate during mammary ...
more infohttp://www.einstein.yu.edu/faculty/9868/cristina-montagna/

Research Opportunities Details | Welcome to SRM University - Indias Premier Educational InstitutionResearch Opportunities Details | Welcome to SRM University - India's Premier Educational Institution

... it has a fundamental role in the cell physiological processes such as DNA replication, DNA mismatch repair, and virulence ... 1. Bacterial Cell Cycle Regulation- Epigenetic mechanisms regulating various physiological activities in the prokaryotic cells ... in this area is to understand how DNA methylation plays a role in coordinating several physiological processes in a cell cycle ... Project- Cell cycle regulation in the bacterial model system Caulobacter crescentus. Advisor - Dr. Emanuele Biondi ...
more infohttp://www.srmuniv.ac.in/research-opportunities-details/9504

Community Academic Profiles - Faculty & Researchers - Stanford MedicineCommunity Academic Profiles - Faculty & Researchers - Stanford Medicine

Interactions among neighboring cells underpin many physiological processes ranging from early development to immune responses. ... A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules CELL ... We demonstrate the ability of this reporter strategy to gauge cell-cell proximity in culture models in vitro and then evaluate ... Our findings identify Par-4-induced multinucleation as a mechanism of cell death in oncogene-addicted cells and establish Par-4 ...
more infohttps://med.stanford.edu/profiles/pathology/thomas-wandless?tab=bio

Tom Wandless | Stanford Medicine ProfilesTom Wandless | Stanford Medicine Profiles

Interactions among neighboring cells underpin many physiological processes ranging from early development to immune responses. ... A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules CELL ... We demonstrate the ability of this reporter strategy to gauge cell-cell proximity in culture models in vitro and then evaluate ... Our findings identify Par-4-induced multinucleation as a mechanism of cell death in oncogene-addicted cells and establish Par-4 ...
more infohttps://med.stanford.edu/profiles/thomas-wandless

JCI -
E-lettersJCI - E-letters

The endocannabinoid system (ECS) regulates multiple physiological processes, including cutaneous cell growth and ...
more infohttps://www.jci.org/eletters/submit/64628

Modulation of plant growth in vivo and identification of kinase substrates using an analog-sensitive variant of CYCLIN...Modulation of plant growth in vivo and identification of kinase substrates using an analog-sensitive variant of CYCLIN...

A pilot set of five proteins involved in a range of different processes could be confirmed in independent kinase assays to be ... Here we have applied a chemical genetic approach and generated an analog-sensitive version of CDKA;1, the central cell-cycle ... Our here performed pilot screen led to the identification of CDK targets that link cell proliferation control to sugar ... Equally, the possibility to deliberately tune kinase activity is of great value to analyze the biological process controlled by ...
more infohttps://bmcplantbiol.biomedcentral.com/articles/10.1186/s12870-016-0900-7

Xiaolu Yang | Cancer | Programs | Penn Institute for Immunology | Perelman School of Medicine at the University of PennsylvaniaXiaolu Yang | Cancer | Programs | Penn Institute for Immunology | Perelman School of Medicine at the University of Pennsylvania

Apoptosis is a physiological process of cell auto-destruction that eliminates unwanted, damaged, or harmful cells. ... Proteins are the most abundant macromolecules in the cell and are critical to virtually all physiological processes. However, ... Cell Reports 18(13): 3143-3154, March 2017.. Guo L., Giasson B.I., Glavis-Bloom A., Brewer M.D., Shorter J., Gitler A.D., and ... Nat Cell Biol. 8: 855-62, 2006 Notes: Commented on in this issue.. Hu S., Du M.-Q., Park S.-M., Alcivar A., Qu L., Gupta S., ...
more infohttp://www.med.upenn.edu/apps/faculty/index.php/g20001883/p20138

Resveratrol induces autophagy-dependent apoptosis in HL-60 cells | BMC Cancer | Full TextResveratrol induces autophagy-dependent apoptosis in HL-60 cells | BMC Cancer | Full Text

It is currently unknown whether resveratrol-induced apoptosis is associated with other physiological processes, such as ... These results suggest that resveratrol induced apoptotic cell death of HL-60 cells depends on the autophagy activated through ... All known mechanisms of apoptosis induced by resveratrol act through cell cycle arrest and changes in mitochondrial membrane ... RSV inhibits cell proliferation and induces cell death in HL-60 cells. To investigate the action of RSV on the cell growth, HL- ...
more infohttps://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4504-5
  • We apply our method to several yeast physiological processes: cell cycle, sporulation, and various stress conditions. (nih.gov)
  • Here we have applied a chemical genetic approach and generated an analog-sensitive version of CDKA;1, the central cell-cycle regulator in Arabidopsis and homolog of the yeast Cdc2/CDC28 kinases. (biomedcentral.com)
  • Substantial work in yeast and animal model systems has shown that high kinase activity levels are in particular required to promote the transition from a gap phase (G1) into S phase where the nuclear DNA becomes replicated and from a second gap phase (G2) into M phase (mitosis) during which the chromosomes are distributed to the newly forming daughter cells. (biomedcentral.com)
  • It has been reported that secretion of purines has a role in synchronizing sporulation among cells in yeast cultures, suggesting a primitive role for purines in cell-cell communication ( Jakubowski and Goldman 1988 ). (g3journal.org)
  • In animals, many of these functions are mediated through vesicular ATP secretion and ATP-binding to purinergic receptors on target cells ( Burnstock 1996 , 2012 ). (g3journal.org)
  • Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental processes such as NEURAL TUBE development. (rush.edu)
  • Our hypothesis is that during malignant transformation, breast epithelial cells undergo genomic amplification of the Sept9 locus and over-express Sept9 mRNA and protein. (yu.edu)
  • Analysis of published microarray data revealed a significant overexpression of LASP1 in PCa metastases compared to parental primary tumors and normal prostate epithelial cells. (uni-wuerzburg.de)
  • Polyploidy and aneuploidy are the most frequent cytogenetic events observed in mammalian cells. (yu.edu)
  • The systems work well in cultured mammalian cells, a variety of model organisms (e.g., flies, worms, frogs) and in living mice and rats. (stanford.edu)
  • This approach allowed us to identify a novel coordinated transcriptional response that mammalian cells trigger when unfolded protein appears (Miyazaki et al. (stanford.edu)
  • Additionally, creating unfolded DD in either the cytosol or nucleus elicits distinct responses, suggesting that mammalian cells maintain different protein quality control surveillance environments in these compartments. (stanford.edu)
  • The inositol trisphosphate receptor Ca2+ release ion channel A focus of the lab is the molecular physiology of intracellular signaling by Ca2+, with a particular focus on unique approaches for studying the properties and regulation of intracellular Ca2+ release channels, especially inositol trisphosphate receptors (InsP3R), and their roles in normal and pathological cell physiological states. (upenn.edu)
  • An important thrust in the lab has been to relate the behaviors of the channels to the properties of the cytoplasmic Ca2+ signals that they generate, and to understand how these signals regulate important physiological and pathological processes. (upenn.edu)
  • Lasp-1 is a ubiquitously expressed, actin-binding protein that is known to regulate cytoskeleton architecture and cell migration. (uni-wuerzburg.de)
  • This screen revealed key cellular processes that regulate extracellular ATP levels, including mitochondrial translation and vesicle sorting in the late endosome, indicating that ATP production and transport through vesicles are required for efflux. (g3journal.org)
  • These include intriguing instances of differing motif dosages and differing combinatorial motif control that promote regulatory specificity in rRNA metabolism under differing physiological processes. (nih.gov)
  • Biochemical and molecular tools are used within the context of physiological measurement, with the goal to understand how molecular behavior results in complex cell physiological processes in normal and disease states. (upenn.edu)
  • Yes-associated protein (YAP) and transcriptional coactivator with PDZ-motif (TAZ) are transcriptional coactivators that also play important roles in normal and neoplastic processes. (rupress.org)
  • The gene functions at the interface between survival and cell death during stress-inducing processes like regeneration and starvation in sexual and asexual races of planarians. (pnas.org)
  • This review describes the molecular components that implement this process, the relevance of these to a variety of human diseases, and discusses the potential for novel therapies based on our understanding of them. (nih.gov)
  • However, currently very little is known about the molecular basis of the integration of the cell cycle with other cell-physiological processes. (biomedcentral.com)
  • However, many aspects of them are still not well elucidated due to the unusual physiological and molecular features of dinoflagellates, and this has impeded our understanding of dinoflagellate-caused HABs and subsequently their monitoring, mitigation, and prevention [ 4 ]. (hindawi.com)
  • Although much effort has been devoted to understanding the cell wall ultrastructure of dinoflagellates using electron microscopic and cytochemical approaches, molecular information on cell wall biogenesis and dynamics is lacking. (hindawi.com)
  • This work has led us into studies of the molecular mechanisms of programmed cell death, the genetically-inherited forms of Alzheimer's disease, and cellular bioenergetics and autophagy with relevance for neurodegenerative diseases and cancer. (upenn.edu)
  • However, cell migration is also critical for metastasis, the spread of cancer cells from the primary site to colonize distant organs ( 1 ). (rupress.org)
  • Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. (uniprot.org)
  • We are studying the proliferative role of caspases to better understand the interplay between cellular life and death processes. (upenn.edu)
  • Physiological cell death plays an important role in development, tissue homeostasis and defence against viral infection and mutation. (nih.gov)
  • We have selected various candidates that we are currently investigating for their role in determining cell fate during mammary gland development and for their implication in breast tumorigenesis. (yu.edu)
  • While the catastrophic consequence of high levels of aneuploidy observed in abortions is self-explanatory, the role of aneuploidy under physiological conditions is a question waiting for answers. (yu.edu)
  • Within this review we will discuss the functional role of immune cells as it pertains to bone fracture healing. (springer.com)
  • Role of immune cells during fracture repair. (springer.com)
  • Current efforts are directed at delineating the exact role these cells play in fracture healing. (springer.com)
  • This review will outline the role of the immune system during fracture healing, then specifically the role of each individual cell type. (springer.com)
  • However, little is known about the physiological role of the protein. (uni-wuerzburg.de)
  • YAP/TAZ have also been implicated in cell migration and metastatic invasion ( 3 ), but the underlying mechanism and any role of YAP/TAZ in controlling cytoskeletal processes has remained unclear. (rupress.org)
  • show that YAP/TAZ play a critical role in enabling persistent cell migration ( 4 ). (rupress.org)
  • These immune cells signal to other cells of the fracture callus, modulating bone healing. (springer.com)
  • Bone fracture healing can be viewed as a four-stage process. (springer.com)
  • Immune cells, which are derived from hematopoietic stem cells, are required for normal bone development and proper fracture healing. (springer.com)
  • While the inflammatory response itself is short-lived, the effects of the immune cells extend beyond the early stages of fracture healing. (springer.com)
  • Thus, immune cells are integral to bone fracture healing. (springer.com)
  • Polyploidization is a widely accepted mechanism for increasing genetic variation in unicellular organisms and for the acquisition of new properties in a variety of cell types (e.g., osteoclast fusion in bone resorption and myoblast fusion in muscle development) and is considered a physiological process. (yu.edu)
  • Specific, Sensitive, and Stable Reporting of Human Mesenchymal Stromal Cell Chondrogenesis. (uams.edu)
  • Mesenchymal progenitor cell recruitment and activation rely on this inflammatory response. (springer.com)
  • The involvement of YAP/TAZ in microtubule organizing center polarization and Golgi reorientation, both essential for cell migration, was also parsed out. (rupress.org)
  • One obvious possibility is that differentiated somatic cells provide the raw material through autophagy. (pnas.org)
  • We are currently studying how the expression of various Sept9 isoforms is regulated in normal and cancer cells and the functional differences between these isoforms. (yu.edu)
  • Cancer cells in the primary tumor need to migrate toward a blood vessel or lymph node before using the vasculature to spread to distant sites. (rupress.org)
  • Bi-specific T-cell engagers (BiTEs) are a class of artificial bispecific monoclonal antibodies that are investigated for the use as anti-cancer drugs. (wikipedia.org)
  • They direct a host's immune system, more specifically the T cells' cytotoxic activity, against cancer cells. (wikipedia.org)
  • Dysfunction of these cells, as seen with age or with metabolic dysregulation, hinders bone repair. (springer.com)
  • In addition, we present evidence of the existence of an alternative MCB-binding pathway, which we confirm using data from two independent cell cycle studies and two other physioloigical processes. (nih.gov)