Cellular functions, mechanisms, and activities.
The functions and activities of living organisms that support life in single- or multi-cellular organisms from their origin through the progression of life.
Nanometer-sized tubes composed mainly of CARBON. Such nanotubes are used as probes for high-resolution structural and chemical imaging of biomolecules with ATOMIC FORCE MICROSCOPY.
Nanometer-sized tubes composed of various substances including carbon (CARBON NANOTUBES), boron nitride, or nickel vanadate.
A lavender, acid-resistant asbestos.
A plant genus of the family LAMIACEAE that is an ingredient of Banxia Houpu (DRUGS, CHINESE HERBAL).
The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.
A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.
Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.
Condition in which no acceleration, whether due to gravity or any other force, can be detected by an observer within a system. It also means the absence of weight or the absence of the force of gravity acting on a body. Microgravity, gravitational force between 0 and 10 -6 g, is included here. (From NASA Thesaurus, 1988)
Condition under normal Earth gravity where the force of gravity itself is not actually altered but its influence or effect may be modified and studied. (From ASGSB Bull 1992;5(2):27)
Travel beyond the earth's atmosphere.
A change in cardiovascular function resulting in a reduction in BLOOD VOLUME, and reflex DIURESIS. It occurs frequently after actual or simulated WEIGHTLESSNESS.
Techniques and routines designed to prevent or reverse unwanted effects of weightlessness experienced during actual and simulated space flight, including physiologic changes related to removal of gravitational loading. Specific measures include creation of artificial gravity, exercise, low-level lower body negative pressure, and use of anti-deconditioning devices. (From Nicogossian, Space Physiology and Medicine, 2d ed, pp294-297)
Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.
Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.
A subclass of lipid-linked proteins that contain a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE which holds them to the CELL MEMBRANE.
Treatments which are undergoing clinical trials or for which there is insufficient evidence to determine their effects on health outcomes; coverage for such treatments is often denied by health insurers.
Persons who receive ambulatory care at an outpatient department or clinic without room and board being provided.
Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.
An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A neoplastic disease of the lymphoreticular cells which is considered to be a rare type of chronic leukemia; it is characterized by an insidious onset, splenomegaly, anemia, granulocytopenia, thrombocytopenia, little or no lymphadenopathy, and the presence of "hairy" or "flagellated" cells in the blood and bone marrow.
A benign familial disorder, transmitted as an autosomal dominant trait. It is characterized by low-grade chronic hyperbilirubinemia with considerable daily fluctuations of the bilirubin level.
Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.
An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Antibodies obtained from a single clone of cells grown in mice or rats.
The decrease in the cell's ability to proliferate with the passing of time. Each cell is programmed for a certain number of cell divisions and at the end of that time proliferation halts. The cell enters a quiescent state after which it experiences CELL DEATH via the process of APOPTOSIS.
A plant genus in the family PAPAVERACEAE, order Papaverales, subclass Magnoliidae.
Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
The combination of genetic and optical methods in controlling specific events with temporal precision in targeted cells of a functioning intact biological system.
Bundles of actin filaments (ACTIN CYTOSKELETON) and myosin-II that span across the cell attaching to the cell membrane at FOCAL ADHESIONS and to the network of INTERMEDIATE FILAMENTS that surrounds the nucleus.
The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.
A RHO GTP-BINDING PROTEIN involved in regulating signal transduction pathways that control assembly of focal adhesions and actin stress fibers. This enzyme was formerly listed as EC 3.6.1.47.
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
Behavior of LIGHT and its interactions with itself and materials.
A purplish-red, light-sensitive pigment found in RETINAL ROD CELLS of most vertebrates. It is a complex consisting of a molecule of ROD OPSIN and a molecule of 11-cis retinal (RETINALDEHYDE). Rhodopsin exhibits peak absorption wavelength at about 500 nm.
A subgroup of cyclic nucleotide-regulated ION CHANNELS of the superfamily of pore-loop cation channels that are opened by hyperpolarization rather than depolarization. The ion conducting pore passes SODIUM, CALCIUM, and POTASSIUM cations with a preference for potassium.
A subgroup of cyclic nucleotide-regulated ION CHANNELS within the superfamily of pore-loop cation channels. They are expressed in OLFACTORY NERVE cilia and in PHOTORECEPTOR CELLS and some PLANTS.
Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.
Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.
The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.
The nonstriated involuntary muscle tissue of blood vessels.
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
A class of cell surface leukotriene receptors with a preference for leukotriene B4. Leukotriene B4 receptor activation influences chemotaxis, chemokinesis, adherence, enzyme release, oxidative bursts, and degranulation in polymorphonuclear leukocytes. There are at least two subtypes of these receptors. Some actions are mediated through the inositol phosphate and diacylglycerol second messenger systems.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The veins and arteries of the HEART.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer. (1/97)

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PID: the Pathway Interaction Database. (2/97)

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Is cell rheology governed by nonequilibrium-to-equilibrium transition of noncovalent bonds? (3/97)

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Robustness analysis of cellular memory in an autoactivating positive feedback system. (4/97)

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Rest-mediated regulation of extracellular matrix is crucial for neural development. (5/97)

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Actin nucleation and elongation factors: mechanisms and interplay. (6/97)

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Genetic and cell biological analysis of integrin outside-in signaling. (7/97)

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Attachment of osteocyte cell processes to the bone matrix. (8/97)

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Cells, either as unicellular organisms or as part of a tissue of a multicellular organism, can acquire different functions thanks to their capability of changing their expression state. The enzyme synthesis, cell division or cell differentiation are some examples of these functions. The turning on and off of them lie in the mechanisms by which cells are able to integrate the information they perceive from the environment. Frequently, cells exhibit different responses under the same stimulus or environment. These probabilistic processes, whose behaviours are not univocal, are known as cellular decision making. We can classify these processes according to the range at which the decision is made. We denominate cell-autonomous decision those in which of each cell chooses its response independently of the choice of the other cells of the population. By contrast, if the decision is made collectively by the whole population, it is classified as non autonomous. This second type of decisions involve ...
Many cellular processes require decision making mechanisms, which must act reliably even in the unavoidable presence of substantial amounts of noise. However, the multistable genetic switches that underlie most decision-making processes are dominated by fluctuations that can induce random jumps between alternative cellular states. Here we show, via theoretical modeling of a population of noise-driven bistable genetic switches, that reliable timing of decision-making processes can be accomplished for large enough population sizes, as long as cells are globally coupled by chemical means. In the light of these results, we conjecture that cell proliferation, in the presence of cell-cell communication, could provide a mechanism for reliable decision making in the presence of noise, by triggering cellular transitions only when the whole cell population reaches a certain size. In other words, the summation performed by the cell population would average out the noise and reduce its detrimental impact ...
Development and the associated cellular differentiation are some of the most fundamental processes in biology. Since the early conception of the Waddington landscape, with cells portrayed as rolling down a landscape, understanding these processes has been at the forefront of biology. Progress in tissue regeneration, organoid culture, and cellular reprogramming relies on our ability to unfold cellular decision making and its dynamics. In this thesis, we ask to what extent development follows such landscape. Secondly, we address whether cellular branching points are discrete events. Given the recent surge in single-cell genomics data, we can now address these fundamental questions. To this end, we analyzed two large-scale single-cell RNAseq time course datasets from vertebrate embryogenesis in zebrafish. From the Waddington analogy, we expect the cell-to-cell correlation to increase across development as cells specialize. Our analysis does not show a linear trend, but rather, that cell-to-cell ...
My laboratory is interested in a variety of signal transduction mechanisms mediated by nucleotides. We are based within the Department of Chemistry and work closely with physicists, chemists, and mathematicians on a number of research questions.. 1. Carbon dioxide sensing. CO2 is a critical constituent of all known biological systems yet its molecular interactions with the cell are relatively unexplored. Cells are exposed to fluctuating CO2 through altered environmental conditions, changes in cell metabolism, and the effects of lifestyle and pathology. Our current work is directed toward understanding how CO2 impacts on cell function through alterations in cellular levels of the second messenger molecule, cAMP.. 2. Resistance protein function. Plant resistance proteins trigger disease resistance in response to pathogen (avirulence) proteins. R-proteins typically consist of a nucleotide binding (NB) domain adjacent to one or more ARC domains and a Leucine Rich Repeat (LRR). The LRR is involved in ...
Objective: We investigated the association of anti-inflammatory cytokines interleukin-1 receptor antagonist (IL-1ra) and adiponectin as well as pro-inflammatory cytokines IL-1β, IL-6, CCL2 and tumor necrosis factor (TNF)-α with β-cell function, metabolic status and clinical remission in patients with recent onset type 1 diabetes.. Research Design and Methods: Serum was obtained from 256 newly diagnosed patients (122 males/134 females, median age 9.6 years). Stimulated C-peptide, blood glucose and HbA1c were determined in addition to circulating concentration of cytokines at one, six and twelve months after diagnosis. Analyses were adjusted for sex, age and BMI percentiles.. Results: Anti-inflammatory IL-1ra was positively associated with C-peptide after six (p=0.0009) and twelve months (p=0.009). The beneficial association of IL-1ra on β-cell function was complemented by the negative association of IL-1β with C-peptide after one month (p=0.009). In contrast, anti-inflammatory adiponectin ...
The body becomes a storage site for chemicals as it is exposed to toxins in our environment, from cigarette smoke and traffic emissions to food pesticides and chemicals in personal care products. The accumulation of these harmful substances takes its toll on our health and vitality, and eventually leads to a host of problems; but with some warning signs. Symptoms that may indicate your body needs a detox include lethargy, headaches, poor concentration, fatigue, infertility, constipation, skin rashes, eczema, allergies, depression, weight gain, muscle aches, and PMS, along with others.. So what exactly is a detox? Detoxification is the process of purifying the body of compounds that have a detrimental effect on cell functions or structures. When one starts the process of detoxification, the body begins to discharge excesses that have been carried for years. According to ancient healing traditions, spring is recognized as the prime season for cleansing the body because the rhythms of the body ...
The folding state of polypeptides is easily perturbed by adverse conditions. Misfolded proteins are non-functional and lead to a measure of inefficiency in the cells economy. Their presence has additional consequences that are unrelated to loss-of-function features as numerous genetic and biochemical observations suggest that structures elaborated by polypeptides that fail to attain their proper three dimensional structure have deleterious gain-of-function effects on cell function. This process, also referred to as proteotoxicity, appears to be particularly important to the fate of non-renewable cells of long-lived organisms in which accumulating misfolded proteins can act over extended periods of time. The hypothesized contribution of such proteotoxins to cellular dysfunction fits our intuitive notions of aging as a time and use-dependent process. The progressive aging of the human population has led to an increase in the incidence of diseases hypothesized to be associated with various ...
We aim to decipher the ground rules of gene regulation and establish their functional interplay in biological phenomena involving global changes in phenotype, such as in cell differentiation and activation. Our current focus is on the role of non-coding DNA elements such as enhancers in integrating and transmitting gene regulatory information.. We combine experimental and computational approaches to study these questions, capitalising on our previous work on promoter-enhancer relationships, organisation of DNA regulatory elements and population genomics. Our particular interest is in human primary cells as models, and in genetic and epigenetic variation as natural perturbations in the system.. Our ultimate goal is to generate comprehensive functional models of gene control logic underlying cellular decisions. Interrogation and validation of these models will pinpoint key individual players (regulatory elements, genes, extrinsic signals) and their regulatory relationships in these processes ...
Won Jang1, Tae-Geun Park1, Soo-Hyun Song1, You-Soub Lee1, Xin-Zi Chi1, Il Yeong Park2, Jin-Won Hyun3, Yoshiaki Ito4 and Suk-Chul Bae 1 The cellular decision ...
Current research topics: 1. Non-equilibrium statistical mechanics 2. Large deviation theory 3. Statistical physics on heterogeneous networks 4. Stochastic dynamics of gene regulation 5. Evolutionary game theory 6. Cellular decision making under demographic and environmental noise 7. Mathematical models of microbial evolution ...
Un exemple typique est notre effort actuel pour imiter divers aspects des cellules (motifs nano-bio en surface, y compris des élastomères mous) ou des tissus (fentes spléniques) en utilisant des techniques de micro/nano-fabrication. Nous innovons dans les techniques dimagerie ainsi que dans les outils danalyse dimages et de données. Un autre axe majeur concerne les capteurs innovants : les nanocapteurs à rayons X pour la topographie et la cartographie chimique simultanées, les capteurs FET à base de lipides pour la détection ultra-sensible dions et de biomolécules et les capteurs photo-thermiques rapides pour la détection de réactions biochimiques par molécule unique.. ...
Can Vitamin D Benefit Patients with Prediabetes? No Effect of High-Dose Vitamin D Treatment on β-Cell Function, Insulin Sensitivity, or Glucose Homeostasis in Subjects With Abnormal Glucose Tolerance: A Randomized Clinical Trial Henrik Wagner1⇑, Michael Alvarsson1, Buster Mannheimer2, Marie Degerblad1 and Claes Göran Östenson1 http://care.diabetesjournals.org/content/early/2016/01/07/dc15 -1057.abstract Abstract OBJECTIVE There has been conflicting evidence regarding the potential role of vitamin D in glucose homeostasis. This study was designed to investigate the effect of high-dose vitamin D3 treatment on β-cell function, insulin sensitivity, and glucose tolerance in subjects with prediabetes or … Continue reading →. ...
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This message is to announce the creation of a new WWW resource deidicated to spreading information regarding the study of chromatin structure, with emphasis on the proteins that modify chromatin structure, and the effects that these modifications have on cell function. Please view this site frequently, because the field is evolving rapidly, and so the website is updated quite often. If you have any suggestions or announcements that you wish posted (Job openings, meetings, etc) my email address is included as part of the page, so feel free to contact me. Thanks, Jim bone Chromatin Structure and Function Page http://rampages.onramp.net/~jrbone/chrom.html ----------------------------------------------------------------------------- James R. Bone Dept. of Biochemistry and Molecular Biology M. D. Anderson Cancer Center, Box 117 1515 Holcombe Avenue Houston, TX 77030 email:jrbone at odin.mdacc.tmc.edu :jrbone at onramp.net voice: 713-792-2549 Roth Lab Homepage-- ...
We have shown that near-total α-cell loss in adult mice has little effect on glucagonemia and no apparent effect on β-cell function or glucose homeostasis. This reveals that 2 to 4% of the normal α-cell mass is astonishingly sufficient to produce enough glucagon to ensure glycemic control under basal conditions. Massive α-cell loss is associated with a rapid enhancement of glucagon sensitivity, which allows increased glucose mobilization, even if the decrease in glucagonemia is very mild.. A corollary of this observation is that the normal amount of pancreatic α-cells apparently exceeds the physiologic requirement for proper blood glucose homeostasis. Indeed, the total glucagon found in the pancreas when only 2% of the α-cells remain was sufficient to maintain normoglucagonemia. A simple calculation reveals that if all pancreatic glucagon found 1 week after α-cell loss (∼7,400 pg; Supplementary Table 2) were entirely released at once into the circulation, glucagonemia would be more than ...
JEOL USA JEOL provides leading-edge electron microscopy and e-beam lithography solutions for 200/300mm, nano-fabrication processes and research.. Microscopy Tools. JEOLs microscopy expertise spans more than 70 years. As the leading global supplier, we offer a full suite of Scanning Electron Microscopes (SEM), Transmission Electron Microscopes (TEM), and sample preparation tools. JEOLs SEMs and TEMs feature advanced automation and capabilities for high throughput, high resolution imaging and analysis. JEOL offers both focused (FIB) and broad ion beam milling systems. Our Cross Section Polisher features air-isolated transfer and cooling for sensitive samples.. Lithography Tools. As the industry leader in direct write e-beam lithography, JEOLs latest generation of tools will take you through several next-generation designs. JEOL has more than 50 years of experience in e-beam and mask writing tools.. Service and Support JEOL USA is a wholly-owned subsidiary that supports the Americas with ...
Systems theory suggests that the slowest evolving variables determine the long term outcome of a system. In a biological context, it is thus the change in gene expression that reflects the macroscopic decision of a cell. Formalizing these ideas in a dynamic modeling approach, we use neural network and rule based modelling approaches to reconstruct the dynamic control logic of cellular decision processes based on gene expression kinetics. Time-resolved experimental data will be recorded in our lab under well defined cell culture and context-dependent conditions. Data is collected on the cell population level using DNA microarrays and RT-PCR as well as on the single cell level by time-lapse microscopy ...
I take glandular supplements about one month. In the beginning i consume only adrenal, thymus and orchic ones in the different products. But the result not so expressive as this product gave me. I think this because of spleen and pancreas tissues maybe. The spleen takes very important role in a growth of lymphocytes. And it takes to be proved this taking spleen glands supplement separately. And of course this product is highly recommended! ...
Cellular Physiology and Biochemistry is a multidisciplinary scientific forum dedicated to advancing the frontiers of basic cellular research. It addresses scientists from both the physiological and bi
Alteration in charge means the membrane acts as a capacitor, with most cells having a resting potential 70-80mV lower than extracellular ...
As indicated above, renin cells communicate with one another and with adjacent cells, including smooth muscle, mesangial cells, and perivascular interstitial cells. Disruption of such communication alters the renin phenotype, demonstrating that the identity of these cells is heavily dependent on the cells context, particularly their interaction with other cell types.. The Notch pathway is an ancestral, highly conserved, cell-to-cell communication system involved in cell fate decisions during development and in response to physiological challenges.54,55 Notch receptors, their ligands, and their final transcriptional effector, RBP-J, are expressed in renin cells.32 We found that the disruption of the Notch pathway either by the inhibition of γ-secretase (unpublished) or conditional deletion of RBP-J in renin cells56 results in severe reduction in the number of renin cells, low circulating renin, and decreased blood pressure. Further, mutant mice are unable to recruit renin cells in response to a ...
Novel features of the present work include the extensive comparison of renin cells with numerous cells types from the renal cortex at different developmental points. Furthermore, we developed a single cell isolation and amplification procedure that allowed us to identify the transcriptome of individual adult JG cells. Specifically, we show that renin cells express a unique set of genes vastly different from other cell types in the kidney: They possess markers that topologically and functionally link them to arterial and interstitial pericytes, and express Akr1b7, a new and valuable marker for renin cells, independent from renin expression. Contrary to arteriolar cells distant from the glomerulus, which transiently express renin during development and/or a homeostatic threat, adult JG cells maintain a dual smooth muscle and renin phenotype, driven by a unique transcriptional network that maintains, at all cost, the cells dual endocrine and contractile functions necessary for the maintenance of ...
Engineering quantum science into quantum reality 16 April 2015 The University of Bristol has today launched its new state-of-the-art Quantum Engineering Technology (QET) Labs. The QET Labs will provide unique world-leading facilities, bringing together industrial and academic collaborators to build devices that span numerous areas of quantum technology development from the nano-fabrication of quantum devices to a city-scale Quantum Key Distribution network. ...
Genetics is a powerful tool, especially when used in combination with embryology, in the seeking of genes necessary for assembly of the cardiovasculature. The first questions must address the types of cellular decisions that are made during development. As for simpler systems in C elegans and D melanogaster, the lineage and cell-fate decisions of the cardiovascular progenitors need to be assessed. In addition it is likely that new paradigms will emerge for multicellular assembly. The study of cardiovascular mutations will define individual genetic steps that define organotypic decisions. A genetic approach is a natural extension of embryology, physiology, and anatomy, fields of great sophistication with regard to the cardiovasculature, because, like them, it focuses on integrative biology and on the intact organism. The zebrafish is particularly well suited to a combination genetic-embryologic study of the fashioning of the cardiovasculature. ...
Expression of CDK11A (CDC2L2, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, p58GTA, PITSLRE) in pancreas tissue. Antibody staining with HPA025061 and CAB010467 in immunohistochemistry.
Expression of ACSBG2 (BGR, DKFZp434K1635, PRTD-NY3) in pancreas tissue. Antibody staining with HPA043421 and HPA051013 in immunohistochemistry.
My research interests include Bacterial Cell Cycle Regulation and Signal Transduction mechanisms.. 1. Bacterial Cell Cycle Regulation- Epigenetic mechanisms regulating various physiological activities in the prokaryotic cells are increasingly being appreciated. Methylation of specific bases of the DNA molecule by methyltransferases is the most common epigenetic modification observed in the bacterial cells. This modification of nucleotides adds another level of regulation at the transcription; furthermore, it has a fundamental role in the cell physiological processes such as DNA replication, DNA mismatch repair, and virulence mechanisms in many pathogens. Among the prokaryotic DNA methyltransferases, Dam expressed among the Gammaproteobacteria is the most intensively studied. In contrast to Dam, another DNA methyltransferase CcrM (Cell Cycle Regulated Methylase) has been described in the Alphaproteobacteria, where it plays an important role in the cell cycle regulation of Caulobacter crescentus ...
From previous studies, it is known that the low OA risk haplogroup J is associated with lower serum levels of markers of collagen type-II degradation and of matrix metalloproteinases, but all of these studies failed to address the key question arising from this large body of evidence: What is the functional role of these mtDNA haplogroups?. To answer this question, Fernandez-Moreno et al7 used cytoplasmic hybrid (cybrid) cell lines. Cybrids incorporate mitochondria from human subjects and perpetuate the mtDNA-encoded components while maintaining the nuclear background of different cybrid lines as constant.16 Thus, this technique allows investigators to assess the influence of mtDNA variation on cell function. To investigate the role of mtDNA haplogroups, they also created cybrids using osteosarcoma cell lines with the same nuclear background, one of them harbouring the haplogroup J (which protects against OA) and another harbouring the haplogroup H (linked to higher risk of OA).. The cybrids ...
Sigma Zeta 2014 Fall Banquet:. On Tuesday, November 4th our own Dr. Nathan Lindquist from the physics department spoke on Interdisciplinary nanotechnology research: the science and its many applications. Over the past few years, Bethel has invested in building a NanoLab for interdisciplinary student/faculty research on microscopy, spectroscopy, imaging, bio-sensing, nano-fabrication and nano-characterization. The recent addition of a Scanning Electron Microscope further builds our potential for cutting-edge projects. The talk provided some background on the science of nanotechnology, the tools of the trade, and its many promising applications. We found out how nano-research is directly aimed at solving some of our biggest challenges in energy, healthcare, and the environment. As is our custom in the fall, our banquet is a combined event with members of the Minnesota Microscopy Society. We had a total of 48 in attendance including students, faculty and MMS members. We recognized new members ...
Cellular decisions to live or die are fundamental to development and adult homeostasis, playing roles in a wide variety of physiological and pathological processes. These include cancer, degenerative disease, innate and adaptive immunity, ischemia-reperfusion injury, and infectious disease. As the study of cell death moves beyond the central mechanisms of apoptosis to wider issues of regulation and other forms of cell death, this vibrant area of research widens its influence and importance for human health and disease.
Pancreatic cancer begins in pancreas tissues. Pancreas lies in the abdomen just behind the lower part of the stomach. These secrete enzymes which help in digestion and hormones which help in regulating sugar metabolism. Often, pancreatic cancer has a poor prognosis even it is diagnosed early. Typically, it spreads rapidly. It is rarely detected in the initial stage. This is the major reason for many pancreatic cancer deaths. Symptoms do not develop till the cancer reaches advanced stage and it is not possible to remove it surgically. Pancreatic Cancer Causes: ...
The Food and Drug Administration is looking into new evidence that suggests a group of recently approved diabetes drugs can increase the risk of pancreatitis and other problems. The agency said Thursday samples of pancreas tissue taken from a small number of patients showed inflammation and cellular changes that often precede cancer. Academic researchers took the samples from diabetes patients who were taking the new medications, after they died from various causes.
A new class of viologen-phosphorus dendrimers (VPDs) has been recently shown to possess the ability to inhibit neurodegenerative processes in vitro. Nevertheless, in the Central Nervous Systems domain, there is little information on their impact on cell functions, especially on neuronal cells. In this work, we examined the influence of two VPD (VPD1 and VPD3) of zero generation (G0) on murine hippocampal cell line (named mHippoE-18). Extended analyses of cell responses to these nanomolecules comprised cytotoxicity test, reactive oxygen species (ROS) generation studies, mitochondrial membrane potential (ΔΨm) assay, cell death detection, cell morphology assessment, cell cycle studies, as well as measurements of catalase (CAT) activity and glutathione (GSH) level. The results indicate that VPD1 is more toxic than VPD3. However, these two tested dendrimers did not cause a strong cellular response, and induced a low level of apoptosis. Interestingly, VPD1 and VPD3 treatment led to a small decline in ROS
Philip Calder is Professor of Nutritional Immunology at the University of Southampton, UK. He has a first class honours degree in biochemistry from Massey University, New Zealand, a PhD in biochemistry from the University of Auckland, New Zealand, and a DPhil in biochemistry from the University of Oxford, UK. He held a Nuffield Medical Fellowship in the Department of Biochemistry, University of Oxford from 1987 to 1991. Professor Calder has been studying the influence of dietary fatty acids on aspects on cell function and human health, in particular in relation to cardiovascular disease, inflammation and immunity, since 1987. In 1995 he was awarded the Sir David Cuthbertson Medal by the UK Nutrition Society for this work and he has been awarded the Belgian Danone Institute Chair for 2004, the Nutricia International Award for 2007, the ESPEN Cuthbertson Lecture for 2008, and the Muriel Bell Award for 2009. Professor Calder served as an elected member of the Council of the UK Nutrition Society and ...
Pancreatic diseases can be very difficult to diagnose and monitor because of the location of the pancreas deep within the abdomen. Also, with the current range of tests it may not be possible (in some cases) to tell the difference between pancreatitis (inflammation of the pancreas) and other conditions such as cancer of the pancreas without surgery and direct biopsy of tissues from this organ. This project is aimed to create a research tissue bank (explained below), specifically for pancreatic diseases. It will help researchers conduct a range of investigations in the near future. Thus this research project aims to develop new diagnostic tests as well as treatments for patients with pancreatic disease.. ...
The MRC laboratories reach users from many different fields: electronics, optics, physics, chemistry, astronomy, as well as chemical, mechanical, and petroleum engineering. Lab users are both from universities and corporates. UT MRC is more than a cleanroom with open-access with a comprehensive set of nano-fabrication equipment - it is a community of scientists who works together to build advanced technology products and knowledge.. ...
TY - JOUR. T1 - Hydrolysis of bis(dimethylamido)tin to tin (II) oxyhydroxide and its selective transformation into tin (II) or tin (IV) oxide. AU - Khanderi, Jayaprakash. AU - Shi, Lei. AU - Rothenberger, Alexander. N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: Research reported in this publication was supported by the King Abdullah University of Science & Technology (KAUST) baseline and AEA funding. We thank the analytical core lab and advanced nano-fabrication, imaging and characterization lab personnel of KAUST for generous access to the facility and help in the IR, Raman and SEM analysis. J.K. thanks Dr. Ali R. Behzad for helping in SnO2 imaging by SEM, Dr. Rachid Sougrat and Ms. Nini Wei for TEM imaging and Dr. Ejaz Ahmed for his comments during the preparation of the manuscript.. PY - 2015/3. Y1 - 2015/3. N2 - Sn6O4(OH)4, a hydrolysis product of Sn(NMe2)2, is transformed to tin (II) or tin (IV) oxide by solid and solution phase processing. Tin (II) oxide is ...
In this module we will discuss different approaches and concepts how tailoring electronic and photonic band structures of solid-state matter can enable us to influence, manipulate and controlle light on the nanoscale. We will begin with a discussion of quantum-confined materials where in particular semiconductors are tailored during growth in order to control and manipulate their electronic properties leading to novel physical concept like non-classical light emission. In contrast to controlling the electronic band structure, nano-fabrication techniques allow us to selectively tailor the structural properties of solid materials giving rise to the full control of the photonic properties. In particular the concept of periodically structured dielectrics - known as photonic crystals - offers a powerful tool to guide, confine and enhance the spontaneous emission of light emitters. Also metallic nanostructures exhibit another way to manipulate light by tailoring their shape, size and composition and ...
Modeling of phenomena observed in biological systems and the search for underlying mechanisms and principles have a long history, with remarkable contributions from Mathematical Biology. The development of the Hodgkin-Huxley model as an explanation of the temporal behavior of excited neurons or the class of predator-prey models for describing the dynamics of competing populations are prominent examples. Their principles can still be found in many areas of research (see e.g. Chapter 2 in [3] or Chapter 3 in [4]). Moreover, although classical Cell Biology was in the past a predominantly reductionist approach, in which cells were broken down into small subsystems, this was always accompanied by models on the system level. Regulation processes that drive cellular decisions, such as the lytic and lysogenic pathway in bacteriophage lambda [5, 6], the diauxic switch between glucose and lactose uptake in bacterial cells [7] or apoptotic decision processes [8], have been in the focus of interest for a ...
In the 1860s, the German scientist Paul Langerhans discovered tiny patches of cells in cross-sections of pancreas tissues. They looked like little islands, hence their name - islets of Langerhans. These islets have a rich blood supply and consist of two type of cells - larger alpha cells and numerous smaller beta cells. The function of these islets were unknown until the 20th century when scientists found that removing the pancreas for an animal resulted in a disease similar to human diabetes (incidentally, dogs and cats can get diabetes too).. It was isolated in the 1920s by Banting, Best & MacLeod in Canada.. Animals with their pancreas removed were treated with the insulin (meaning island), and this cured the animals of the diabetes. Animal insulin was then successfully used to treat humans for many years before genetic engineering took over the production.. ...
Nuclear lamins are type V intermediate filament proteins that form a filamentous meshwork beneath the inner nuclear membrane. Additionally, a sub-population of A-type and B-type lamins is localized in the nuclear interior. The nuclear lamina protects the nucleus from mechanical stress and mediates nucleo-cytoskeletal coupling. Lamins form a scaffold that partially tethers chromatin at the nuclear envelope. The nuclear lamina also stabilizes protein-protein interactions involved in gene regulation and DNA repair. The lamin-based protein sub-complexes are implicated in both nuclear and cytoskeletal organization, the mechanical stability of the nucleus, genome organization, transcriptional regulation, genome stability, and cellular differentiation. Here we review recent research in the field of nuclear lamins and their role in modulating various nuclear processes and their impact on cell function.
Each cell division, the nuclear DNA must be replicated efficiently and with high accuracy to avoid mutations which can have an effect on cell function. There are three replicative DNA polymerases essential for the synthesis of DNA during replication in eukaryotic cells. DNA polymerase α (Pol α) synthesize short primers required for DNA polymerase δ (Pol δ) and DNA polymerase ε (Pol ε) to carry out the bulk synthesis. The role of Pol δ and Pol ε at the replication fork has been unclear. The aim of this thesis was to examine what role Pol ε has at the replication fork, compare the biochemical properties of Pol δ and Pol ε, and to study the function of the second largest and essential subunit of Pol ε, Dpb2.. To identify where Pol ε replicates DNA in vivo, a strategy was taken where the active site of Pol ε was altered to create a mutator polymerase leaving a unique error-signature. A series of mutant pol ε proteins were purified and analyzed for enzyme activity and fidelity of DNA ...
Author(s): Lodico, Jared Joseph | Advisor(s): Regan, Brian C. | Abstract: Graphite intercalation compounds are critically important in modern technology and todays economy. For instance, they serve as the anode in the ubiquitous lithium-ion battery. However, despite considerable efforts to understand intercalation compounds, their behavior during charging and discharging at the macromolecular level is still not well understood, even in idealized circumstances. Recent developments in nano-fabrication have brought forth a platform to study this dynamical process with the high spatial resolution of an electron microscope. We expanded on and developed new fabrication techniques to form ultra-thin, in situ fluid cells. With this platform we imaged the graphite intercalation process with an optical and a transmission electron microscope (TEM). Optical videos show, vividly the graphite flake charging and discharging and give insight to the lithium-graphite structure over multiple cycles. Our TEM images
Nanotechnology has been developed for decades and many interesting optical properties have been demonstrated. However, the major hurdle for the further development of nanotechnology depends on finding economic ways to fabricate such nanostructures in large-scale. Here, we demonstrate how to achieve low-cost fabrication using nanosphere-related techniques, such as Nanosphere Lithography (NSL) and Nanospherical-Lens Lithography (NLL). NSL is a low-cost nano-fabrication technique that has the ability to fabricate nano-triangle arrays that cover a very large area. NLL is a very similar technique that uses polystyrene nanospheres to focus the incoming ultraviolet light and exposure the underlying photoresist (PR) layer. PR hole arrays form after developing. Metal nanodisk arrays can be fabricated following metal evaporation and lifting-off processes. Nanodisk or nano-ellipse arrays with various sizes and aspect ratios are routinely fabricated in our research group. We also demonstrate we can ...
Detection of Mouse Shrew-1/AJAP1 by Western Blot. Western blot shows lysates of mouse brain (cortex) tissue, mouse brain (thalamus/hypothalamus) tissue, and mouse pancreas tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Mouse Shrew-1/AJAP1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7970) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Shrew-1/ AJAP1 at approximately 45-50 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1 ...
Dipeptidyl peptidase-4 inhibitors, such as saxagliptin, have been reported to have beneficial effects on β-cell function, but the specific underlying mechanism remains unclear. Stromal cell-derived factor-1α (SDF-1α), a chemokine produced in multiple organs, has been considered as a crucial regulator in promoting β-cell survival. Here, we speculate that SDF-1α might mediate the effect of saxagliptin on improving β-cell function. After 12-week saxagliptin treatment in high-fat diet/streptozotocin-induced diabetic rats, significant improvement in pancreas insulin secretion capacity evaluated by hyperglycemia clamp and increased β-cell to α-cell areas ratio were observed. Saxagliptin significantly induced β-cell proliferation and upregulated the expression of proliferation-related factors including c-myc and cyclind D1 determined with western blotting from the isolated islets. The expression/activity of DPP-4 was significantly reduced and paralleled with the restoration of SDF-1α levels in the
The book covers areas of cellular physiology and metabolism that are of interest to scientists involved in research in diabetes and metabolic diseases. Some chapters of the book are specifically research-oriented, as all the authors are actively practicing either bench or clinical research in the
The Paperback of the Cellular Physiology of Nerve and Muscle by Gary G. Matthews at Barnes & Noble. FREE Shipping on $25 or more!
Hyperglucagonemia is an important factor for type 2 diabetes which contributes to increased hepatic glucose production (Rizza 2010). In spite of this, however, little is known about the role of chronically elevated glucagon levels for β-cell function. A reason for this is the lack of appropriate models of long-term glucagon action, which in part is due to difficulties in administering native glucagon long-term because of poor chemical and physical stability. Therefore, in the current study, we administered a stable glucagon analog (ZP-GA-1) to mice fed a HFD to create a novel model for studying effects of chronic GCGR activation on β-cell function. The HFD fed mice do not develop hyperglucagonemia (Ahlkvist et al. 2013) which allowed us to study the impact of chronic GCGR stimulation on glucose tolerance in a glucose intolerant model without the confounding factor of endogenous hyperglucagonemia. In these mice, 2-week ZP-GA-1 infusion markedly reduced the insulin response to oral glucose. ...
The project would include but not be limited to applications of single molecule spectroscopy to understanding of protein folding reactions. Candidates should have a recent Ph.D. in engineering, chemistry, physics, materials science or a related field. The work will involve design, fabrication & characterization of the microfluidics devices and their applications. The candidate would have access to research facilities at both at Center for Biophotonics S&T at UC Davis and at Lawrence Livermore National Laboratory. Opportunities also exist for close collaboration with Single Molecule Biophysics Group at UCLA http://smb.chem.ucla.edu/ and with the laboratory of Prof. L. Lapidus at Michigan State (http://www.pa.msu.edu/~lapidus/introduction.htm). Experience in as many of the following disciplines is not necessary but it would be a plus: computational fluid dynamics, micro- and nano-fabrication, microfluidics, fluorescence microscopy. The ideal candidate would be a person with experience in one of ...
Mechanism and Process in Physiological Evolution". Oxford: Oxford University Press. Cite journal requires ,journal= (help) v t ... Cell Bio. Methods in Cell Biology. 84: 679-735. doi:10.1016/S0091-679X(07)84022-2. ISBN 9780123725202. PMID 17964947. Hochachka ... restoring normal cell volume. Osmolytes also interact with the constituents of the cell, e.g. they influence protein folding. ... When a cell swells due to external osmotic pressure, membrane channels open and allow efflux of osmolytes which carry water ...
"Genomic Imprinting and Physiological Processes in Mammals". Cell. 176 (5): 952-965. doi:10.1016/j.cell.2019.01.043. PMID ... This process of erasure and reprogramming is necessary such that the germ cell imprinting status is relevant to the sex of the ... Genomic imprinting is an inheritance process independent of the classical Mendelian inheritance. It is an epigenetic process ... of the parents and are maintained through mitotic cell divisions in the somatic cells of an organism. Appropriate imprinting of ...
Hall-Glenn F, Lyons KM (October 2011). "Roles for CCN2 in normal physiological processes". Cell. Mol. Life Sci. 68 (19): 3209- ... CCN proteins have been shown to play important roles in many cellular processes, including cell adhesion, migration, ... Cell Biol. 41 (4): 771-83. doi:10.1016/j.biocel.2008.07.025. PMC 2668982. PMID 18775791. Holbourn KP, Acharya KR, Perbal B ( ... Huang W, Pal A, Kleer CG (March 2012). "On how CCN6 suppresses breast cancer growth and invasion". J Cell Commun Signal. 6 (1 ...
Hall-Glenn F, Lyons KM (October 2011). "Roles for CCN2 in normal physiological processes". Cell. Mol. Life Sci. 68 (19): 3209- ... promotes endothelial cell survival, and induces angiogenesis in vivo". Mol. Cell. Biol. 19 (4): 2958-66. doi:10.1128/mcb.19.4. ... CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, ... inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis". Mol. ...
Afanas'ev IB (2005). "Free radical mechanisms of aging processes under physiological conditions". Biogerontology. 6 (4): 283-90 ... Furthermore, a study using cultured smooth muscle cells displayed increased reactive oxygen species (ROS) in cells derived from ... look at free radicals in the aging process. Trends In Cell Biology. 2011;21(10) 569-76. Erbas M, Sekerci H. IMPORTANCE OF FREE ... Cell. 157 (4): 897-909. doi:10.1016/j.cell.2014.02.055. PMC 4454526. PMID 24813612. Brewer GJ (2010). "Epigenetic oxidative ...
... the process by which a cell changes from one cell type to another. In particular, naive mesenchymal stem cells (MSCs) have been ... Changes in physiological conditions can trigger protease activities that cause local release of such stores. This allows the ... Cell adhesion[edit]. Many cells bind to components of the extracellular matrix. Cell adhesion can occur in two ways; by focal ... Plant cells are tessellated to form tissues. The cell wall is the relatively rigid structure surrounding the plant cell. The ...
Each of these bodies is composed of a similar collection of cells, and it is the post-transduction signal processing that ... Physiological Reviews. American Physiological Society. 74 (4): 829-898. doi:10.1152/physrev.1994.74.4.829. ISSN 0031-9333. PMID ... Each of these peripheral chemoreceptors is composed of type I glomus cells and glia-like type II cells. The type-I cells ... Type II cells occur in a ratio of about 1 to 4 with type I cells. Their long bodies usually occur in close association with ...
Without regulation, proteases will destroy many essential proteins for physiological processes. One way the body regulates ... A polypeptide chain in the cell does not have to stay linear; it can become branched or fold in on itself. Polypeptide chains ... Protein anabolism is the process by which proteins are formed from amino acids. It relies on five processes: amino acid ... The process of bind an amino acid to a tRNA is known as tRNA charging. Here, the enzyme aminoacyl-tRNA-synthetase catalyzes two ...
Main article: Physiological plant disorders. Abiotic disorders can be caused by natural processes such as drought, frost, snow ... Cell wall-degrading enzymes: These are used to break down the plant cell wall in order to release the nutrients inside. ... in order to allow cell to cell movement through plasmodesmata, and sometimes a protein that allows transmission by a vector. ... Pathogens such as Erwinia species use cell wall-degrading enzymes to cause soft rot. Agrobacterium species change the level of ...
During this process, epithelial cells lose expression of proteins like E-cadherin, Zonula occludens 1 (ZO1), and cytokeratin. ... It also regulates physiological regeneration processes. Wnt signaling and beta-catenin dependent gene expression plays a ... "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". Journal of Cell Science. 116 (Pt 24): 4985 ... These cell-cell adhesion complexes are necessary for the creation and maintenance of epithelial cell layers and barriers. As a ...
This allows for investigation into developmental or physiological processes in animal models. The targeted DamID (TaDa) ... A DamID protocol for single cells has also been developed and applied to human cells. Single cell approaches can highlight the ... "Genome-wide maps of nuclear lamina interactions in single human cells". Cell. 163 (1): 134-147. doi:10.1016/j.cell.2015.08.040 ... In stable cell lines or fully transgenic animals, this bias is not observed as no plasmid DNA is recovered. Apoptotic cells ...
... and can be physiological or pathological. It is related to peripolesis, which is the attachment of one cell to another. ... Autoimmune hepatitis Leukocyte migration from the blood stream to tissues through endothelial cells, in a process also known as ... Emperipolesis is the presence of an intact cell within the cytoplasm of another cell. It is derived from Greek (en is inside, ... Instead, the engulfed cell remains viable within the other, and can exit at any time without causing structural or functional ...
Nevertheless, considerable evidence suggests that the Type-II photo-oxygenation process predominates in the induction of cell ... Many photosensitisers are poorly soluble in aqueous media, particularly at physiological pH, limiting their use.[5] ... Type-I processes[edit]. Type-I processes can be divided into Type I(i) and Type I(ii). Type I (i) involves the transfer of an ... Type-II processes[edit]. Type-II processes involve the direct interaction of the excited triplet state photosensitiser (3Psen ...
Water in and between cells in the plant freezes and expands, causing tissue damage. Cold hardening is a process in which a ... Cold hardening is the physiological and biochemical process by which an organism prepares for cold weather. Plants in temperate ... and without cold hardening the cell would rupture. To protect the cell membrane from expansion induced damage, the plant cell ... Cold increases cell membrane permeability and makes the cell shrink, as water is drawn out when ice is formed in the ...
... the basic physiological functions of cells can be divided into the processes of cell division, cell signaling, cell growth, and ... Cells[edit]. Main article: Cell physiology. Although there are differences between animal, plant, and microbial cells, ... Levandowsky, M. Physiological Adaptations of Protists. In: Cell physiology sourcebook: essentials of membrane biophysics. ... Central to physiological functioning are biophysical and biochemical processes, homeostatic control mechanisms, and ...
The pineal gland in Proteus probably possesses some control over the physiological processes.[17] Behavioral experiments ... The pineal body also has photoreceptive cells which, though regressed, retain visual pigment like the photoreceptive cells of ... Behavioural Processes 43: 107-113 *^ Istenič, L.; Bulog, B. (1979). "The structural differentiations of the buccal and ... Self-purification processes in the underground waters are not completely understood, but they are quite different from those in ...
In all living organisms, intracellular calcium controls a wide variety of physiological processes. Extracellular stimuli ... Hint2, one of the three members of the Hint family of proteins, is localized to mitochondria of various cell types. In human ... Lenglet S, Antigny F, Vetterli L, Dufour JF, Rossier MF (Nov 2008). "Hint2 is expressed in the mitochondria of H295R cells and ... As such, HINT2 plays a prominent role in mitochondrial cell death signaling (e.g. apoptosis) and in ischemia-reperfusion injury ...
This action mimics physiological processes observed during T cell attacks against tumor cells. Helwick C (June 2008). "Novel ... solitumab forms a link between T cells and its target tumor cell antigen. This causes T cells to exert cytotoxic activity on ... These proteins enter tumor cells and initiate the cell's apoptosis. ... One of the scFvs binds to T cells via the CD3 receptor, and the other to EpCAM as a tumor antigen against gastrointestinal, ...
... the physiological process can be beneficial for the body. This process is known as immunothrombosis. The process isolates ... invariant natural killer T cells, kupffer cells, platelets, and mast cells. These cells express particular receptors such as ... and molecules that are released by damaged cells, DAMPs. Immune cells involved in intravascular surveillance are neutrophils, ... Circulating immune cells behave differently in the presence and absence of an infection. For example, in the absence of an ...
... so the immune cells' effective setpoint may be even higher than the setpoint for physiological processes. GRMF affects ... so the effective setpoint for the immune cells may be even higher than the setpoint for physiological processes (reflecting ... alpha by antigen-presenting cells (APCs) and T helper (Th)1 cells, but upregulates IL-4, IL-10, and IL-13 by Th2 cells. This ... It prevents proliferation of T-cells by rendering the interleukin-2 producer T-cells unresponsive to interleukin-1 (IL-1), and ...
Artificial cells essentially function as point processes, implemented into the network. Artificial cells require only a point ... Segments are the points where point process managers can be associated. Users can define kinetic and electro-physiological ... Cells can be managed. The user creates the basic grid of network cells, taking previously completed network cells as archetypes ... Connections can be defined between source cells and target synapses on other cells. The cell containing the target synapse ...
The process, termed Homologous desensitization, serves as a physiological limiter of cell responses to DP2 activators.[12][13][ ... an increase in the expression of DP2 by these cells, an enhanced rate of differentiation of precursor cells to Th2 cells in ... DP2 was found to stimulate the directed movement or chemotaxis of human T-helper type 2 cells (see T helper cell#Th1/Th2 Model ... cell cycle genes in fetal testes which contribute to the arrest of mitotic process and to the differentiate of germ cells. This ...
The next larger scale, cell biology, studies the structural and physiological properties of cells, including their internal ... the phenomenon of energy flow occurs in cells in processes that are part of the function known as metabolism. Finally, cells ... and that all cells arise from other cells through cell division. In multicellular organisms, every cell in the organism's body ... Cell theory. Human cancer cells with nuclei (specifically the DNA) stained blue. The central and rightmost cell are in ...
... and epigenetic levels and abnormal cell division. Cell division is a physiological process that occurs in almost all tissues ... Cancer stem cells may arise from transformation of adult stem cells or differentiated cells within a body. These cells persist ... and stem cells are the only cells that can transmit DNA from the zygote to cells late in life. Other cells cannot keep DNA from ... Each cell has a chance of damage. Cells often die if they are damaged, through failure of a vital process or the immune system ...
It was produced by the repeated passage of the virus through nonhuman cells at subphysiological temperatures.[55] The ... In addition to these physiological processes, the body can compensate for residual paralysis in other ways. Weaker muscles can ... Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV Merkel-cell carcinoma. RNA virus. HCV ... The virus then hijacks the host cell's own machinery, and begins to replicate. Poliovirus divides within gastrointestinal cells ...
... is the general physiological process of reabsorption and breakdown of tissues, involving apoptosis. When it occurs as a ... Atrophy is reduction in size of cell, organ or tissue, after attaining its normal mature growth. In contrast, hypoplasia is the ... it may be induced by a combination of a gradual failure in the satellite cells which help to regenerate skeletal muscle fibers ... excessive amount of apoptosis of cells, and disuse or lack of exercise or disease intrinsic to the tissue itself. In medical ...
... cell lysis; degranulation of mast cells, basophils, and eosinophils; and other processes). In a new development in the field of ... In this way, it mediates different physiological effects of antibodies (detection of opsonized particles; ... The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors ... The Fc region is, therefore, sometimes incorrectly termed the "fragment constant region". Fc binds to various cell receptors ...
Some important physiological processes the plant H+ -ATPase is involved in are: Phloem loading. The phloem is a tissue ... Like the somatal pore, other movements of plant organs are controlled by motor cells' changing cell turgor. These cells control ... Plasma membrane H+ -ATPases are found throughout the plant in all cell types investigated, but some cell types have much higher ... This creates and maintains an electrochemical gradient of H+ from outside the cell to inside the cell. Secondary active ...
... s help regulate physiological processes, such as circadian behavioral rhythms and neuronal excitability. BK channels ... the secretion of endocrine cells, and the proliferation of cells. Various γ subunits during early brain development are ... This was found when the BK ɑ-subunit was knocked out in mice and progressive loss of cochlear hair cells, and thus hearing loss ... Not only are BK channels important in many cellular processes in the adult it also is crucial for proper nutrition supply to a ...
Cell signallingEdit. Bile acids have metabolic actions in the body resembling those of hormones, acting through two specific ... All four of these bile acids recycled, in a process known as enterohepatic circulation.[2][3] ... that play important roles in several physiological pathways including stress and pain responses, appetite, and lifespan. NAPE- ... Bile acid synthesis occurs in liver cells, which synthesize primary bile acids (cholic acid and chenodeoxycholic acid in humans ...
Some physiological carnivores consume plant matter and some physiological herbivores consume meat. From a behavioral aspect, ... The brain detects insulin in the blood, which indicates that nutrients are being absorbed by cells and a person is getting full ... Learning to eat is a messy process for children, and children often do not master neatness or eating etiquette until they are 5 ... Aestivation: Molecular and Physiological Aspects. Springer-Verlag. pp. 95-113. doi:10.1007/978-3-642-02421-4. ISBN 978-3-642- ...
M phase of mitotic cell cycle. · mitotic prophase. · mitotic anaphase. · mitotic cell cycle. · apoptotic process. · cellular ... The role of lamins and mutations of LMNA gene in physiological and premature aging]. Postepy Biochem. 2007, 53 (1): 46-52. PMID ... regulation of apoptotic process. · cellular protein metabolic process. · ventricular cardiac muscle cell development. · ... Halaschek-Wiener J, Brooks-Wilson A. Progeria of stem cells: stem cell exhaustion in Hutchinson-Gilford progeria syndrome. J. ...
The branched-chain amino acids or BCAAs (leucine, isoleucine, and valine) are critical to this process, in addition to lysine ... During that time, bears go through a series of physiological, morphological and behavioral changes. Their ability to maintain ... "satellite cells" which help to regenerate skeletal muscle fibers, and a decrease in sensitivity to or the availability of ... accompanied by a smaller number and size of the muscle cells as well as lower protein content. In humans, prolonged periods of ...
Invasins, such as pneumolysin, an antiphagocytic capsule, various adhesins, and immunogenic cell wall components are all major ... For a bacterium to bind, take up, and recombine exogenous DNA into its chromosome, it must enter a special physiological state ... Transformation is a complex developmental process requiring energy and is dependent on expression of numerous genes. In S. ... and white blood cells to fill the alveoli. This condition is called pneumonia.[20] It is susceptible to clindamycin.[21] ...
Outer hair cells serve as acoustic amplifiers for stimulation of the inner hair cells. Outer hair cells respond primarily to ... A natural physiological reaction to these threshold shifts is vasoconstriction, which will reduce the amount of blood reaching ... It has been seen that this process can reduce sound waves by up to 50 decibels. Although this mechanism can decrease the sound ... "J. Cell Biol. 164 (6): 887-97. doi:10.1083/jcb.200310055. PMC 2172292. PMID 15024034.. ...
... stem cells, white blood cells) in many tissues and organs. SP amplifies or excites most cellular processes.[15][16] ... With the exception of chemotherapy-induced nausea and vomiting, the patho-physiological basis of many of the disease groups ... The above processes are part and parcel to tissue integrity and repair. Substance P has been known to stimulate cell growth in ... on cells (including cancer cells) bestowing upon them mobility.[40] and metastasis.[41] It has been suggested that cancer ...
... modern biotechnology allows drugs targeted towards specific physiological processes to be developed, sometimes designed for ... discovered by Paul Ehrlich in 1908 after he observed that bacteria took up toxic dyes that human cells did not. The first major ... Molecular biology is the study of molecular underpinnings of the process of replication, transcription and translation of the ... Epidemiology is the study of the demographics of disease processes, and includes, but is not limited to, the study of epidemics ...
The second sperm cell fuses with two cell nuclei, producing a triploid (3n) cell. ... The process begins when a pollen grain sticks to the stigma of the pistil (female reproductive structure). Then it germinates, ... Lotz, CN and JE Schondube (2006). "Sugar preferences in nectar- and fruit-eating birds: behavioral patterns and physiological ... This cell divides by mitosis into two haploid sperm cells. As the pollen tube grows, it makes its way from the stigma, down the ...
Potassium is the major cation (positive ion) inside animal cells,[223] while sodium is the major cation outside animal cells.[ ... The process may be speeded up by a catalyst. Similar solutions are formed by the heavy divalent alkaline earth metals calcium, ... the minimum physiological requirement for sodium is 500 milligrams per day.[225] Sodium chloride (also known as common salt) is ... The balance between potassium and sodium is maintained by ion transporter proteins in the cell membrane.[231] The cell membrane ...
Cell Biol. 42 (6): 813-27. doi:10.1016/j.biocel.2009.11.013. PMID 19931639.. ... Androgen synthesis inhibitors are enzyme inhibitors that prevent the biosynthesis of androgens.[62] This process occurs mainly ... Neumann F (1978). "The physiological action of progesterone and the pharmacological effects of progestogens--a short review". ... Bennett NC, Gardiner RA, Hooper JD, Johnson DW, Gobe GC (2010). "Molecular cell biology of androgen receptor signalling". Int. ...
cell nucleus. • cytosol. Biological process. • regulation of transcription, DNA-templated. • cell-cell signaling. • negative ... As demonstrated in progesterone receptor-deficient mice, the physiological effects of progesterone depend completely on the ... epithelial cell maturation. • mammary gland development. • paracrine signaling. • lung alveolus development. • regulation of ... epithelial cell proliferation both in response to estrogen alone and in the presence of progesterone and estrogen. These ...
"sickle cell disease". Genetics Home Reference. Retrieved 2016-11-11.. *^ MD, Kenneth R. Bridges. "How Does Sickle Cell Cause ... Unfortunately, the process of antagonistic pleiotropy may result in an altered evolutionary path with delayed adaptation, in ... effects between comb mass and physiological structures related to reproductive abilities. Both males and females with larger ... Sickle cell anemia is a genetic disease that causes deformed red blood cells with a rigid, crescent shape instead of the normal ...
The process of ecdysis involves forming a new layer of skin under the old one. Proteolytic enzymes and lymphatic fluid is ... Davis, Jon R.; DeNardo, Dale F. (2007-04-15). "The urinary bladder as a physiological reservoir that moderates dehydration in a ... Cell. 25 (4): 326-328. doi:10.1016/j.devcel.2013.05.011. PMID 23725759.. ... Traumatic injuries on the other hand, form scars that will not allow new scales to form and disrupt the process of ecdysis.[94] ...
In this process, fats, obtained from adipose tissue, or fat cells, are broken down into glycerol and fatty acids, which can be ... "Physiological Validation of the Concept of Glycemic Load in Lean Young Adults" (PDF). The Journal of Nutrition. USA (published ... When the body is expending more energy than it is consuming (e.g. when exercising), the body's cells rely on internally stored ... "Glycemic index of foods: a physiological basis for carbohydrate exchange" (PDF). American Journal of Clinical Nutrition. USA. ...
Deamer went on to earn a PhD in Physiological Chemistry in 1965 at the Ohio State University School of Medicine. His advisor ... Deamer described he significance of self-assembly processes in his 2011 book First Life. In collaborative work with Mark Akeson ... Deamer, D.W.; Baskin, R.J. (1969). "Ultrastructure of sarcoplasmic reticulum preparations". Journal of Cell Biologoy. 42: 296- ...
Transendothelial fluid exchange occurs predominantly in the capillaries, and is a process of plasma ultrafiltration across a ... Where the endothelial glycocalyx overlies an inter endothelial cell cleft, the plasma ultrafiltrate may pass to the ... The principles behind the equation are considered useful for explaining physiological phenomena happening at the capillary such ...
... only one cell released into the environment could exponentially grow into many thousands of cells over a short amount of time. ... Native species can be threatened with extinction[113] through the process of genetic pollution. Genetic pollution is ... "Pseudo-nitzschia physiological ecology, phylogeny, toxicity, monitoring and impacts on ecosystem health". Harmful Algae. 14: ... For organisms between 10 and 50 microns, such as certain types of phytoplankton, current regulations allow less than 10 cells ...
There, CRH and vasopressin act synergistically to stimulate the secretion of stored ACTH from corticotrope cells. ACTH is ... As well as directly increasing glucose availability, cortisol also suppresses the highly demanding metabolic processes of the ... the physiological role of the HPA axis and corticosteroids in stress response is so fundamental that analogous systems can be ... in immune cells, such as monocytes and neutrophils [8][9][11][12] ...
New York: American Physiological Society. pp. 89-127. ISBN 978-0195091748. .. *^ Taylor A, Durbaba R, Ellaway PH, Rawlinson S ( ... This information can be processed by the brain as proprioception. The responses of muscle spindles to changes in length also ...
That as the body attempts to compensate for low iron levels by increasing red blood cell production in the young, sieve-like ... Enamel hypoplasia refers to transverse furrows or pits that form in the enamel surface of teeth when the normal process of ... and because of physiological changes associated with pregnancy, such as suppression of the immune system and a possible ... These changes were widely used to study activity-patterns, but research has shown that processes associated with aging have a ...
A component of bones (see apatite), cells, in energy processing, in DNA and ATP (as phosphate) and many other functions Red ... It is not known whether lithium has a physiological role in any species,[50] but nutritional studies in mammals have indicated ... "Cell. 157 (6): 1380-1392. doi:10.1016/j.cell.2014.05.009. PMC 4144415 . PMID 24906154.. ... Required for processing ATP and for bones Spinach, legumes, nuts, seeds, whole grains, peanut butter, avocado[22] ...
The process leading to β-1,6 linkages is poorly understood: although genes important in the process have been identified, not ... β-Glucans (beta-glucans) comprise a group of β-D-glucose polysaccharides naturally occurring in the cell walls of cereals, ... increasing fecal bulk and producing short-chain fatty acids as byproducts with wide-ranging physiological activities.[14] This ... One of the most common sources of β(1,3)D-glucan for supplement use is derived from the cell wall of baker's yeast ( ...
Plasmids may be transferred between cells by physical contact, in a process that may be similar to bacterial conjugation.[132][ ... Extremophile archaea are members of four main physiological groups. These are the halophiles, thermophiles, alkaliphiles, and ... Further information: Cell wall § Archaeal cell walls. Most archaea (but not Thermoplasma and Ferroplasma) possess a cell wall.[ ... Cell division is controlled in a cell cycle; after the cell's chromosome is replicated and the two daughter chromosomes ...
... that trap the protein-DNA intermediate could result in it being toxic to the cell once they encounter a DNA processing event. ... Influence of species, physico-chemical properties of insulin and physiological factors". Danish Medical Bulletin. 38 (4): 337- ... "Molecular Cell. 68 (1): 130-143.e5. doi:10.1016/j.molcel.2017.08.016. PMC 5632562. PMID 28918903.. ... In specific cell types or on specific promoters TBP can be replaced by one of several TBP-related factors (TRF1 in Drosophila, ...
... is a cognitive-physiological theory on alcohol abuse in which many of alcohol's social and stress-reducing ... GABA produces its normal inhibitory effects on cell activity by reducing a neuron's firing rate. When a GABA molecule attaches ... By depriving the individual of the attention capacity necessary to process undesirable thoughts, alcohol myopia can bring the ... Alcohol's myopic effects on the drinker's cognitive processes can be characterized into three classes: self-inflation, relief, ...
This suggests the merging between the spatial- emotiono-tonal processing of the right brain and the linguistical processing of ... The hair cells in the cochlea release neurotransmitter as a result, causing action potentials down the auditory nerve. The ... Johnson, P. B.; Ferraina, S.; Bianchi, L.; Caminiti, R. (1996). "Cortical networks for visual reaching: physiological and ... The motor area processes the rhythm of the music (Dean, 2013).[citation needed] The motor area of the brain is located in the ...
... (HACE) is a medical condition in which the brain swells with fluid because of the physiological ... If a lumbar puncture is performed, it will show normal cerebral spinal fluid and cell counts but an increase in pressure.[7] In ... This process has been observed in MRI studies. Hypoxia increases extracellular fluid, which passes through the vasogenic ... Patients with HACE have an elevated white blood cell count, but otherwise their blood count and biochemistry are normal. ...
... is concerned with the physiological properties, metabolic processes, signaling pathways, life cycle, chemical ... ProcessesEdit. Growth and developmentEdit. The growth process of the cell does not refer to the size of the cell, but instead ... For this process the cell goes through the steps of the cell cycle and development which involves cell growth, DNA replication ... When the cell has completed its growth process, and if it is found to be damaged or altered it undergoes cell death, either by ...
In a physiological context, fasting may refer to the metabolic status of a person who has not eaten overnight, or to the ... In the process of revising the Book of Common Prayer in various provinces of the Anglican Communion the specification of ... Some scientists have indicated that a fast will cause white blood cells to break down during the fasting, resulting in new ones ...
"Cell Physiological Processes" by people in this website by year, and whether "Cell Physiological Processes" was a major or ... "Cell Physiological Processes" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Cell Physiological Processes*Cell Physiological Processes. *Physiological Processes, Cell. *Processes, Cell Physiological ... Below are the most recent publications written about "Cell Physiological Processes" by people in Profiles. ...
... in human bronchial-epithelial cells (BEAS-2B). Asbestos (crocidolite) w ... Oxidative-processes; Physiological-effects; Pulmonary-disorders; Pulmonary-system; Pulmonary-system-disorders; Quantitative- ... in human bronchial-epithelial cells (BEAS-2B). Asbestos (crocidolite) was used as a positive control. Exposure of BEAS-2B cells ... Cell-morphology; Cytotoxic-effects; Exposure-levels; Fibrous-bodies; Immunotoxins; Inhalation-studies; Lung-cells; Lung- ...
Cell-metabolism; Cellular-transport-mechanism; Analytical-methods; Analytical-processes; Physiology; Physiological-function; ... Physiological-response; Physiological-stress; Bone-structure; Bone-disorders; Musculoskeletal-system; Musculoskeletal-system- ... Cell-biology; Cell-differentiation; Cell-function; ...
In this review, we will address these molecular and functional features of AhR biology within physiological and pathological ... array of physiologically relevant genes either by traditional transcription-dependent mechanisms or by unforeseen processes ... cell adhesion and cell migration. Two exciting new aspects in AhR biology deal with its implication in the control of cell ... cell adhesion and cell migration. Two exciting new aspects in AhR biology deal with its implication in the control of cell ...
Pathologic Processes. Aldesleukin. Cyclophosphamide. Fludarabine. Immunosuppressive Agents. Immunologic Factors. Physiological ... The purpose of this study is to determine a safe number of these cells to infuse and to see if these tumor fighting cells (anti ... Peripheral blood mononuclear cells (PBMC) obtained by leukapheresis will be cultured in order to stimulate T-cell growth. ... Biological: Anti-mesothelin chimeric T cell receptor (CAR) transduced peripheral blood lymphocytes (PBL) Day 0: Cells will be ...
Pathologic Processes. Antibodies. Immunoglobulins. Antibodies, Monoclonal. Immunologic Factors. Physiological Effects of Drugs ... Patients also receive infusions of their own previously collected progenitor cells (primitive cells that can make new cells to ... The blood is circulated through a cell-separating machine, where the white cells, including the progenitor cells, are extracted ... T-cell number, phenotype, cytokine profiles) and study the process of post-chemotherapy T-cell regeneration. ...
Neoplastic Processes. Pathologic Processes. Rituximab. Cladribine. Antineoplastic Agents. Immunologic Factors. Physiological ... 2nd malignancies with low activity which do not require treatment (i.e. low grade prostate cancer, basal cell or squamous cell ... Cladribine With Simultaneous or Delayed Rituximab to Treat Hairy Cell Leukemia. The safety and scientific validity of this ... Hairy cell leukemia (HCL) is highly responsive to but not curable by cladribine (CdA). HCL responds to rituximab, which is not ...
Here, we examined the possibility that the epigenetic state of enhancers determines senescent cell fate. We explored this by ... Senescent cells affect many physiological and pathophysiological processes. While select genetic and epigenetic elements for ... transcriptomes and epigenome profiles during oncogenic RAS-induced senescence and validating central findings in different cell ... the organizational principles of the transcription factor network that drives the transcriptional programme of senescent cells ...
Structures and Cellular Processes scheduled on April 29-30, 2022 in April 2022 in Jerusalem is for the researchers, scientists ... Processes. Growth and development. Other cellular processes. Techniques used to study cells. Physiological properties. Cell ... Cell Biology, Structures and Cellular Processes. ICCBSCP 2022: 16. International Conference on Cell Biology, Structures and ... Origin of the first cell. Origin of eukaryotic cells. Metabolic processes. Signaling pathways. Life cycle Interactions with ...
Processes. Growth and development. Other cellular processes. Techniques used to study cells. Physiological properties. Cell ... Origin of the first cell. Origin of eukaryotic cells. Metabolic processes. Signaling pathways. Life cycle Interactions with ... Active transport and passive transport - movement of molecules into and out of cells.. Autophagy Adhesion Cell movement Cell ... Object-Centric Process Mining Using Process Cubes. Anahita Farhang Ghahfarokhi, Alessandro Berti, Wil M.P. van der Aalst ...
Neoplastic Processes. Pathologic Processes. Bone Diseases. Musculoskeletal Diseases. Hematologic Diseases. Zoledronic Acid. ... Zoledronic Acid Combined Radiotherapy for Bone Metastasis of Non-small Cell Lung Cancer. The safety and scientific validity of ... Non-small Cell Lung Cancer Bone Metastasis Drug: Zoledronic acid Radiation: Radiotherapy Phase 4 ... Peng H, Ma M, Han B. [Survival analysis of 1,742 patients with stage IV non-small cell lung cancer]. Zhongguo Fei Ai Za Zhi. ...
... the process by which localized biochemical signals are translated into cell-level responses is poorly understood. Here we ... Cellular contractility is regulated by the GTPase RhoA, but how local signals are translated to a cell-level response is not ... Cytoskeletal mechanics regulates cell morphodynamics and many physiological processes. While contractility is known to be ... only stimulates local recruitment of actin and myosin but also increased traction forces that rapidly propagate across the cell ...
It regulates thought, emotion, and our physiological processes. What do we really know… ... Brain cell identified as mediator of disease. Written by Ana Sandoiu on September 15, 2018. - Fact checked by Jasmin Collier ... Defining these cells through their in vivo activity is an important first step, as it can help to guide therapeutic development ... In this article, we discuss the most fascinating cell type in the human body. We explain what a neuron looks like, what it does ...
Cell. Mol. Life Sci. 66 470-94 2009. GO terms. Biological Process. GO:0006813 potassium ion transport GO:0002027 regulation of ... Cell. Mol. Life Sci. 66 470-94 2009. Wahl-Schott C, Biel M. HCN channels: structure, cellular regulation and physiological ... Cell. Mol. Life Sci. 66 470-94 2009. Notomi T, Shigemoto R. Immunohistochemical localization of Ih channel subunits, HCN1-4, in ... It is also strongly expressed in some parts of the brain, such the thalamic nuclei and the mitral cell layer of the olfactory ...
Plant miRNAs mediate diverse biological processes associating with growth, development, and environmental stress responses ... Plant Cell 11:865-874CrossRefGoogle Scholar. *. Maathuis FJ (2009) Physiological functions of mineral macronutrients. Curr Opin ... Plant miRNAs mediate diverse biological processes associating with growth, development, and environmental stress responses ... TaMIR2275 targets eight genes that encode proteins involving various biological processes, including stress defense, ...
... stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell ... stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell ... Functions and Dysfunctions of Physiological Processes Involved in Tumor Genesis and Malignancy. * Front Matter Pages 337-337 ... The Role of Cell Adhesion, Cell Junctions, and Extracellular Matrix in Development and Carcinogenesis ...
... to recombinant complex protein overproduction in the yeast pichia pastoris under high cell density cultivation process ...
Stress, Physiological / immunology*. T-Lymphocytes / immunology. Virus Diseases / immunology. Chemical. Reg. No./Substance: 0/ ... This impairment of antigen processing and presentation by corticosterone was also observed in non-immune cells, suggesting that ... Cell Line. Corticosterone / physiology*. Dendritic Cells / immunology*. Histocompatibility Antigens Class I / immunology*. ... DCs are specialized for antigen acquisition (by direct infection or uptake from neighboring cells), transport, processing, and ...
This study also showed that LTB4 induces two important physiological responses in human coronary artery SMC (namely, chemotaxis ... to link these responses to pathophysiological processes. Our data point to an important role for LTB4 in SMC activation, ... Whole-cell recordings from human coronary artery SMC. (Upper) Cells were voltage-clamped by using whole-cell configuration at - ... Cell Migration. Aliquots of 10,000 cells in 0.1 ml of DMEM were seeded in 12-well chemotaxis chambers with a gelatin-coated ...
Genomic imprinting and physiological processes in mammals. Cell 176(5), pp. 952-965. (10.1016/j.cell.2019.01.043) ... Genomic imprinting and physiological processes in mammals. Cell 176(5), pp. 952-965. (10.1016/j.cell.2019.01.043) ... Chromatin signatures of pluripotent cell lines. Nature Cell Biology 8(5), pp. 532-538. (10.1038/ncb1403) ... Chromatin signatures of pluripotent cell lines. Nature Cell Biology 8(5), pp. 532-538. (10.1038/ncb1403) ...
Stem cell harvesting methodologies * Mechanical impact of processing on stem cells * Dynamic control of the physiological ... i) Stem cell bioprocessing. Veraitch, F.S., Scott, R., Wong, J.W., Lye, G.J., Mason, C. The impact of manual processing on the ... The impact of process stress on suspended anchorage-dependent mammalian cells as an indicator of likely challenges for ... Mapping of correlated cell membrane pulsations and fluctuations in human cells. Journal of Molecular Recognition. 20, 1-9. doi: ...
The Genetic Basis of Plant Physiological Processes by John King, 9780195048575, available at Book Depository with free delivery ... Cell and. Environment. show more ... The Genetic Basis of Plant Physiological Processes. *Hardback. ... This book shows how the study of fundamental plant physiological processes is being advanced through the science of genetics. ... 4, 1993 Although the author states that his objective is not to provide a complete account of plant physiological genetics, ...
Cell-metabolism; Cellular-transport-mechanism; Analytical-methods; Analytical-processes; Physiology; Physiological-function; ... Physiological-response; Physiological-stress; Bone-structure; Bone-disorders; Musculoskeletal-system; Musculoskeletal-system- ... Cell-biology; Cell-differentiation; Cell-function; ...
Physiological-response; Humans; Psychological-processes; Women; Cellular-reactions; Cell-function; Author Keywords: Job ... cells (ß = .142; p = .107). Job satisfaction did not correlate with numbers of T (CD3+CD56-) and B (CD19+) cells in both women ... cells and NK cell cytotoxicity (NKCC) and completed a questionnaire survey during April to June 2002. Job satisfaction was ... Our findings suggest an independent association between job satisfaction and NK cells but the association seems to be stronger ...
Tissue or cell type. Physiological process. Enzyme or process affected by AMPK. ... cell growth, cell cycle progression, mitosis, cell polarity, development, auto- and mitophagy (Amato et al., 2011; Bungard et ... B) Hormones, cytokines, physiological processes and environmental stressors. Insulin. Inhibition of AMPK activation; mediated ... Compounds, physiological processes and stress. Mode of action and effect on AMPK. ...
An important issue concerns the physiological mechanisms by which support influences such health endpoints. In this... ... Esterling, B. A., Kiecolt-Glaser, J. K., Glaser, R. (1996). Psychosocial modulation of cytokine-induced natural killer cell ... Recent research on immune-mediated inflammatory processes is also starting to provide data on more integrative physiological ... Social Support and Health: A Review of Physiological Processes Potentially Underlying Links to Disease Outcomes. ...
3. A process as claimed in claim 1 characterized in that the perfusion fluid employed is a physiological saline solution ... 4. A process as claimed in claim 3, characterized in that after passing through the measuring cell the perfusion fluid is ... Process for using a measuring cell assembly for glucose determination. US 5174291 A ... Connected to the flow element (8) is a measuring cell (11) also referred to as electrode, said measuring cell being connected ...
Part VI Physiological Processes 24 Materials Exchange in the Body 25 Nutrition: Food and Diet 26 The Bodys Control Mechanisms ... Part III Molecular Biology, Cell Division and Genetics 8 DNA and RNA: The Molecular Basis of Heredity 9 Cell Division 10 ... Part VI Physiological Processes 24 Materials Exchange in the Body 25 Nutrition: Food and Diet 26 The Bodys Control Mechanisms ... Part III Molecular Biology, Cell Division and Genetics 8 DNA and RNA: The Molecular Basis of Heredity 9 Cell Division 10 ...
Physiological differences between simple and complex cells in layer 6. The response patterns of simple cells and complex cells ... these axons split into many short processes that ended within ∼100 μm of the apical dendrite. The cell also directed a ... 1984)illustrate two complex cells whose projection patterns resemble those made by simple cells. Complex cells fall into two ... Cells favoring the upper aspect of layer 2+3. Figure 4 A shows a striking example of a cell that favored the upper tier of the ...
These cells comprise the major class of photoreceptor cells in Drosophila. The R1-R6 photoreceptor cells dominate the ... 1990) Opsin of Calliphora peripheral photoreceptors R1-6. Homology with Drosophila Rh1 and posttranslational processing. J Biol ... The spectral and physiological properties of the DrosophilaR8 photoreceptor cells have been difficult to examine because of ... Each ommatidium contains a bundle of 8 photoreceptor cells and 12 auxiliary cells. The photoreceptor cells differ in their ...
  • These effects of thrombin are seen in a variety of physiological as well as pathological phenomena, including vascular development and physiology, tumor progression and metastasis, neuronal functions, inflammation, angiogenesis. (powells.com)
  • In addition, major tolerance mechanisms that employ ion transporters, proteins, osmoprotectants, antioxidants, and other factors involved in signaling cascades and transcriptional control are activated to offset stress-induced biochemical and physiological alterations. (mdpi.com)
  • which primarily considers aspects of basic biochemical and physiological research. (scribd.com)
  • The pervasive effects of temperature on biochemical and physiological processes are thought to play a fundamental role in shaping the distribution and abundance of organisms. (biologists.org)
  • At the molecular level, AhR regulates an increasingly large array of physiologically relevant genes either by traditional transcription-dependent mechanisms or by unforeseen processes involving genomic insulators, chromatin dynamics and the transcription of mobile genetic elements. (frontiersin.org)
  • Furthermore our data suggests that this pathway regulates neural crest cell migration through the generation of actin-rich pro-migratory structures implying that comparable mechanisms are used to control cell migration during embryogenesis and malignancy metastasis. (buenavidaestudio.com)
  • Cytoskeletal mechanics regulates cell morphodynamics and many physiological processes. (nature.com)
  • It regulates thought, emotion, and our physiological processes. (medicalnewstoday.com)
  • Regulates many physiological processes including cell survival, migration and differentiation. (uniprot.org)
  • Granzymes are synthesized as inactive pro-granzymes and need to be proteolytically activated by cathepsins C and H. Cystatin F is the main regulator of the activity of cathepsins C and H in cytotoxic cells and, consequently, regulates their cytotoxicity. (srce.hr)
  • Two exciting new aspects in AhR biology deal with its implication in the control of cell differentiation and its more than likely involvement in cell pluripotency and stemness. (frontiersin.org)
  • In this review, we will address these molecular and functional features of AhR biology within physiological and pathological contexts. (frontiersin.org)
  • We explored this by generating time-resolved transcriptomes and epigenome profiles during oncogenic RAS-induced senescence and validating central findings in different cell biology and disease models of senescence. (nature.com)
  • aims to bring together leading academic scientists, researchers and research scholars to exchange and share their experiences and research results on all aspects of Cell Biology, Structures and Cellular Processes. (waset.org)
  • Also, high quality research contributions describing original and unpublished results of conceptual, constructive, empirical, experimental, or theoretical work in all areas of Cell Biology, Structures and Cellular Processes are cordially invited for presentation at the conference. (waset.org)
  • ICCBSCP 2022 has teamed up with the Special Journal Issue on Cell Biology, Structures and Cellular Processes . (waset.org)
  • The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. (springer.com)
  • However, new research into factors that regulate α-cell biology is illuminating its role. (diabetesjournals.org)
  • Plant Cell Biology is a semester long course for undergraduates and graduate students which integrates mathematics and physics, two years of chemistry, genetics, biochemistry and evolution disciplines. (google.com)
  • Having taught this course for over ten years, the author uses his expertise to relate the background established in plant anatomy, plant physiology, plant growth and development, plant taxonomy, plant biochemistry, and plant molecular biology courses to plant cell biology. (google.com)
  • This integration attempts to break down the barrier so plant cell biology is seen as an entr e into higher science. (google.com)
  • Distinguishing this book from papers that are often used for teaching the subject which use a single plant to demonstrate the techniques of molecular biology, this book covers all aspects of plant cell biology without emphasizing any one plant, organelle, molecule, or technique. (google.com)
  • In vitro-generated DC, such as DC generated from peripheral blood monocytes (monocyte-derived DC, MO-DC) or bone marrow precursors, both serve as tools for immunotherapy and a model to understand the basic cell biology and biochemistry of DC ( 3 , 4 ). (jimmunol.org)
  • It's an intriguing discovery in the field of stem cell biology and for researchers looking to develop therapies for tissue or organ regeneration," said senior author Xiaolu Yang, PhD , a professor of Cancer Biology and an investigator at the Abramson Family Cancer Research Institute in the Perelman School of Medicine at the University of Pennsylvania. (pennmedicine.org)
  • Biology (Sci) : The cell: ultrastructure, division, chemical constituents and reactions. (mcgill.ca)
  • Tagged proteins are then isolated and identified by mass spectrometry and followed up by cell and molecular biology experiments to establish individual roles of these proteins in tetanus toxin propagation. (ucl.ac.uk)
  • Advanced knowledge in the field of stem cell biology and their ability to provide a cue for counteracting several diseases are leading numerous researchers to focus their attention on "regenerative medicine" as possible solutions for cardiovascular diseases (CVDs). (hindawi.com)
  • A team of researchers led by Thimios Mitsiadis, professor at the Institute of Oral Biology of the University of Zurich, has now published two studies that elucidate how stem cells promote neuronal growth in tissue regeneration and in cancer progression. (innovations-report.com)
  • This book will be of value to researchers and academic professionals both in basic and clinical science who are interested in the fields of biochemistry, biophysics, cell biology, pharmacology, cancer, inflammation, angiogenesis, cardiovascular system and neuronal system. (powells.com)
  • Methods in Cell Biology. (wikipedia.org)
  • Traditionally considered as a critical intermediate in the toxic and carcinogenic response to dioxin (2,3,7,8-tetrachlorodibenzo- p -dioxin, TCDD), the Aryl hydrocarbon/Dioxin receptor (AhR) has proven to be also an important regulator of cell physiology and organ homeostasis. (frontiersin.org)
  • The present investigations were focused on understanding the cellular and molecular mechanisms induced by raw SWCNT (SWCNT) in human bronchial-epithelial cells (BEAS-2B). (cdc.gov)
  • At the cellular level, AhR establishes functional interactions with signaling pathways governing cell proliferation and cell cycle, cell morphology, cell adhesion and cell migration. (frontiersin.org)
  • HCN channels: structure, cellular regulation and physiological function. (ebi.ac.uk)
  • This impairment of antigen processing and presentation by corticosterone was also observed in non-immune cells, suggesting that stress may affect essential cellular protein management functions in all cells, and having possible implications for neurological or other diseases that may result from aberrant protein processing. (biomedsearch.com)
  • As a result of AMPK activation, the cellular metabolism switches from anabolic to catabolic processes. (intechopen.com)
  • Mechanical stress can modulate physiological processes at the molecular, cellular, and systemic level. (nih.gov)
  • A team of researchers, led by Pier Paolo Pandolfi, at Beth Israel Deaconess Medical Center, Boston, has identified a new type of cellular senescence (i.e., irreversible arrest of cell growth) and determined a way to enhance it to suppress prostate tumor development and growth in mice. (eurekalert.org)
  • Cellular senescence is an essential tumor suppressive mechanism that prevents the propagation of oncogenically activated, genetically unstable, and/or damaged cells. (imperial.ac.uk)
  • Recently, understanding of many molecular interactions has progressed appreciably and cellular events once thought to be by-products of more important reactions or to be detrimental to cellular function are now known to be part of complex interactions of the cell with its environment. (nih.gov)
  • to enhance students' ability to understand and evaluate evidence underlying descriptions of cellular processes. (ncl.ac.uk)
  • and (b) effects of variation in nitrogen (N) concentration of the medium on cellular polyamine concentration in transgenic and non-transgenic cells. (usda.gov)
  • Cells grown in the presence of supplemental (to the normal concentrations of N sources in the growth medium) and reduced amounts of NH 4 N0 3 and KN0 3 were used to study effects on membrane permeability, mitochondria1 respiratory activity, protein accumulation, growth rates and changes in cellular polyamine concentration. (usda.gov)
  • Chemokines, small protein chemoattractants, decorate the stromal network of fibroblasts and epithelial cells that create the cellular framework of secondary lymphoid organs through which lymphocytes continually recirculate ( 8 ). (jimmunol.org)
  • Cold hardening is a process in which a plant undergoes physiological changes to avoid, or mitigate cellular injuries caused by sub-zero temperatures. (wikipedia.org)
  • Ca2+ homeostasis and the plasma membrane Na+/Ca2+ exchanger are vital to many cellular functions and physiological processes. (wiley.com)
  • It has become increasingly evident in recent years that, apart from the key role that thrombin plays in the blood coagulation cascade, thrombin also elicits cellular actions via the activation of proteinase-activated receptors, which are present in many cell types. (powells.com)
  • MiRNAs have been involved in regulating gene expression and diverse physiological and pathological processes. (hindawi.com)
  • Cysteine cathepsins are implicated in various physiological and pathological processes. (srce.hr)
  • Biothiols and SO 2 play crucial roles in many physiological and pathological processes. (rsc.org)
  • An important issue concerns the physiological mechanisms by which support influences such health endpoints. (springer.com)
  • Recent research on immune-mediated inflammatory processes is also starting to provide data on more integrative physiological mechanisms potentially linking social support to health. (springer.com)
  • Induction of tumor cell senescence is also one of the underlying mechanisms by which cancer therapies exert antitumor activity. (imperial.ac.uk)
  • All these primary cells/tissues were treated with nanomolar concentrations of ouabain (50nM, 100nM and 500nM) to investigate its degree of cytotoxicity and mechanisms leading to cell death. (imperial.ac.uk)
  • emphasizes altered physiological mechanisms in cells and organ systems. (nau.edu)
  • Presentation of principles needed to appreciate the physiological mechanisms unique to plants. (umass.edu)
  • General areas include components and functions of cell structures and mechanisms of development. (umass.edu)
  • Finally, we have uncovered elaborate transcription regulation refinement mechanisms involving PAC and mRRPE motifs that govern essential rRNA processing. (nih.gov)
  • Non-PAR mechanisms of cell regulation mediated by thrombin and other proteinases 2.6.1. (powells.com)
  • We believe the phenomenon we describe here provides mechanistic insights for the regulation of gene allelic expression and mRNA dosage control necessary for fine-tuning physiological processes in mammals. (pnas.org)
  • Mechanosensitivity, i.e. the specific response to mechanical stimulation, is common to a wide variety of cells in many different organisms ranging from bacteria to mammals. (nih.gov)
  • The process of autophagy is conserved among yeast to mammals. (taconic.com)
  • The small round bodies inside cells represent lysosomes, with the pink color indicating ones that are undergoing chaperone-mediated autophagy (CMA), a selective form of autophagy that is demonstrated only in mammals. (pennmedicine.org)
  • However, unlike the other forms, which are present in all eukaryotic cells, CMA is unique to mammals. (pennmedicine.org)
  • So far, nine isoforms of ACs have been cloned in mammals and their expression has been investigated in various tissues and cells. (calstatela.edu)
  • Our results with Drosophila exhibit surprising similarities in some respects to what we know about the regulation of resting phases in mammals, allowing for speculation as to whether the Hippo signaling pathway in neural stem cells functions in the same manner in both vertebrates and invertebrates," stated the paper's first author Rouven Ding. (eurekalert.org)
  • No, cells stop working before they die so loss of function could kill before morphological changes take place in the cell. (brainscape.com)
  • Study of the physiological, morphological, and behavioral adaptations of desert plants and animals. (utep.edu)
  • Gene co-option in physiological and morphological evolution. (antievolution.org)
  • RNAi-and/or inhibitor experiments followed by the analyses of physiological and morphological effects). (uni-giessen.de)
  • The molecular regulation underlying the competition between elastic and viscous processes in cells is not well understood. (nature.com)
  • It is required for the formation of adult pacemaker cells during embryonic heart development and for the cAMP-dependent up-regulation of embryonic heart rate. (ebi.ac.uk)
  • TaMIR2275 targets eight genes that encode proteins involving various biological processes, including stress defense, transcriptional regulation, signaling transduction, and trafficking. (springer.com)
  • Our results indicate that TaMIR2275 is essential in plant N deprivation response through transcriptional regulation of target genes that involve the N acquisition-associated process. (springer.com)
  • Physiological processes rely on the regulation of total mRNA levels in a cell. (pnas.org)
  • In the immune response they are involved in antigen processing and presentation, the cytotoxicity of natural killer (NK) cells and cytotoxic T lymphocytes (CTL), migration and adhesion of immune cells, cytokine and growth factor regulation and toll-like receptor signalling. (srce.hr)
  • importantly, cystatin F has a crucial role in the regulation of immune cell cytotoxicity. (srce.hr)
  • The role of cystatins and cysteine cathepsins in the immune response is presented, with emphasis on their role in the regulation of cytotoxicity of NK cells and CTLs. (srce.hr)
  • Project 2- Stage- and Cell Subtype-Specific Epigenetic Regulation of Mammary Gland Development and breast tumorigenesis. (yu.edu)
  • New ideas on physiological modes of regulation have been increasingly testable through the use of transgenic animal models. (wiley.com)
  • 9. New Modes of Exchanger Regulation: Physiological Implications: John P. Reeves, Madalina Condrescu, Jason Urbanczyk, and Olga Chernysh. (wiley.com)
  • While contractility is known to be largely RhoA-dependent, the process by which localized biochemical signals are translated into cell-level responses is poorly understood. (nature.com)
  • Plant miRNAs mediate diverse biological processes associating with growth, development, and environmental stress responses through regulating target genes at the posttranscriptional or translation level. (springer.com)
  • Dendritic cells (DCs) play a pivotal role in the generation of both primary and memory CTL responses. (biomedsearch.com)
  • Coordination of the responses of these cells is critical for the proper function of the cardiovascular system. (sciencemag.org)
  • We analyzed the responses of hundreds of endothelial cells to carbachol (CCh) and adenosine triphosphate (ATP) and found that the endothelium segregates the responses to these two distinct components of the chemical environment into separate streams of complementary information that are processed in parallel. (sciencemag.org)
  • This course will provide a brief overview of the physiological responses and adaptations observed in humans during exposure to microgravity. (nau.edu)
  • This course will serve as an overview of the physiological responses to exercise. (nau.edu)
  • The physiological and biochemical responses to heat stress are active research areas, and the molecular approaches are being adopted for developing HT tolerance in plants. (mdpi.com)
  • A discerning feature of simple cells is that their responses display orientation and positional selectivity. (wikipedia.org)
  • Topics include an overview of evolution, systematics, and biogeography of recent and fossil fishes, functional anatomy of feeding and locomotory systems, reproduction and reproductive behavior, physiological adaptations to aquatic habits, etc. (umass.edu)
  • In this study, BLT 1 receptor proteins were detected in human carotid artery atherosclerotic plaques, colocalizing with markers for macrophages, endothelial cells, and vascular smooth muscle cells (SMC). (pnas.org)
  • The transgenes expressed are fluorescence reporters to analyze neuroanatomical aspects of the mushroom body, proteins to restrict ectopic gene expression to mushroom bodies, or fluorescent sensors to monitor physiological parameters of neuronal activity of Kenyon cells. (frontiersin.org)
  • Deficiency of SumF1 is associated with lysosomal storage disorders (LSDs) which results in severe neurodegeneration due to inability of degradation of intracellular proteins by the process of autophagy 11 . (taconic.com)
  • Serum-free media and reagents have a wide range of applications, including production of monoclonal antibodies, viral antigens, and recombinant proteins using a variety of mammalian and invertebrate cell lines. (sartorius.com)
  • Protein Metabolism o Proteolysis- process of breaking down proteins o Protease- enzyme that breaks down proteins o Keto acids- class of breakdown products formed from the deamination oxidative acids. (majortests.com)
  • LPL is the only member of the plastin subclass of actin-bundling proteins expressed in hematopoietic cells. (jimmunol.org)
  • To examine the cell-specific location of AMPK ±1 and ±2 subunit proteins in the ovary, immunohistochemical studies are being performed. (calstatela.edu)
  • Ongoing immunohistochemical analysis with a confocal microscopy system will reveal the cell-specific localization of AMPK ±1 and ±2 subunit proteins in the ovary, providing new insight into the possible roles of this enzyme in regulating reproductive functions. (calstatela.edu)
  • In addition, Berger's team has identified two surface proteins located on the neural stem cells and the surrounding niche glial cells that are responsible for the interactions between these cells. (eurekalert.org)
  • When the scientists remove these surface proteins from the niche glial cells, the stem cells begin to grow and prematurely form new daughter cells. (eurekalert.org)
  • When the larvae begin to eat, the surface proteins Crumbs and Echinoid on the niche glial cells are deactivated about ten hours later and the stem cells begin to grow. (eurekalert.org)
  • Leukotriene B 4 (LTB 4 ), a potent leukocyte chemoattractant derived from the 5-lipoxygenase metabolism of arachidonic acid, exerts its action by means of specific cell surface receptors, denoted BLT 1 and BLT 2 . (pnas.org)
  • Challenge of human coronary artery SMC with either LTB 4 or U75302, a partial agonist that is selective for the BLT 1 receptor, induced an ≈4-fold increase of whole-cell currents by using the patch-clamp technique, indicating that these cells express functional BLT 1 receptors. (pnas.org)
  • Following successful rearrangement of the Ig locus to generate and express IgM, immature B cells emigrate from the bone marrow, guided by receptors for S1P ( 13 - 15 ). (jimmunol.org)
  • Nerves release one or more neurotransmitters, which act chemically on receptors in the membrane of the cells across the synaptic cleft. (encyclopedia.com)
  • In addition to its central role in blood coagulation, it has become increasingly apparent that thrombin and thrombin receptors are involved in many other physiological processes and can contribute to a variety of disease states such as tumor progression and metastasis, inflammation, neurological disorders and cardiovascular complications. (powells.com)
  • Thrombin and thrombin receptors are involved in many physiological processes and can contribute to a variety of disease states. (powells.com)
  • Cell type specific expression of thrombin receptors 3.3. (powells.com)
  • Are Calcium Channels More Important Than Calcium Influx for Cell Proliferation? (springer.com)
  • Investigation of the mechanism for α-cell proliferation led to the description of a conserved liver-α-cell axis where glucagon is a critical regulator of amino acid homeostasis. (diabetesjournals.org)
  • In return, amino acids regulate α-cell function and proliferation. (diabetesjournals.org)
  • The induction of autophagy reduces 60% growth of lymphoma cells by inhibiting cell proliferation 3 . (taconic.com)
  • Moreover, miR-30a has demonstrated its role in biological processes, including inhibiting proliferation and metastasis in many tumors, autophagy in chronic myelogenous leukemia, and regulating TGF-b1-induced epithelial-mesenchymal transition. (hindawi.com)
  • Several reports have confirmed that the miR-30a can significantly inhibit cancer cell proliferation [ 15 , 18 ]. (hindawi.com)
  • RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. (uniprot.org)
  • Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. (uniprot.org)
  • Pooling the results of these anatomical studies with our own suggests a common feature of the laminar organization: cells that project to different intracortical targets have distinct functional characteristics. (jneurosci.org)
  • The Drosophila visual system contains multiple classes of photoreceptor cells that differ in anatomical location, synaptic connections, and spectral sensitivity. (jneurosci.org)
  • This course provided a good basic overview of the principles of nutrition and its role in both anatomical and physiological functions. (straighterline.com)
  • The results of this study show that the molecular mechanism for raw SWCNT-mediated toxicity in BEAS-2B cells is through the activation of caspase-3, caspase-7, and PARP-1. (cdc.gov)
  • Understanding this mechanism of Ag processing can be useful both for vaccine design and toward a selective manipulation of Ag presentation during an autoimmune response. (jimmunol.org)
  • Autophagy is a cell-eating mechanism necessary for survival and function of most living organisms. (pennmedicine.org)
  • To determine whether LPL is required for motility of B lymphocytes and to further elucidate the mechanism by which LPL functions in lymphocyte motility, we investigated the dependence of B cell motility and B cell development on LPL. (jimmunol.org)
  • Several of the papers provide important new insights into the mechanism of photoreceptor degeneration and cell death. (springer.com)
  • Polyploidization is a widely accepted mechanism for increasing genetic variation in unicellular organisms and for the acquisition of new properties in a variety of cell types (e.g., osteoclast fusion in bone resorption and myoblast fusion in muscle development) and is considered a physiological process. (yu.edu)
  • We postulate that the mechanism behind such changes is connected with the toxic effect of metals on gut epithelial cells. (biomedsearch.com)
  • The approach was to combine whole-cell recording with intracellular staining in vivo . (jneurosci.org)
  • These spectral sensitivities are in excellent agreement with intracellular recordings of the R8p and R8y cells measured in Calliphora and Musca . (jneurosci.org)
  • Each agonist evoked distinct intracellular signals, but communication between the different cell clusters generated new composite signals when both agonists were present. (sciencemag.org)
  • Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. (uniprot.org)
  • When cells self-eat, the intracellular materials are delivered to lysosomes, which are organelles that help break down these materials. (pennmedicine.org)
  • When the intracellular water freezes, the cell will expand, and without cold hardening the cell would rupture. (wikipedia.org)
  • It is also strongly expressed in some parts of the brain, such the thalamic nuclei and the mitral cell layer of the olfactory bulb [ PMID: 18953682 , PMID: 14991560 ]. (ebi.ac.uk)
  • Peripheral blood mononuclear cells (PBMC) obtained by leukapheresis will be cultured in order to stimulate T-cell growth. (clinicaltrials.gov)
  • Our studies have also defined a role for Tks5 in the formation of invadopodia actin-rich membrane protrusions that coordinate cell migration with pericellular proteolysis in vitro and tumor growth in vivo [17] [18]. (buenavidaestudio.com)
  • Novel Honokiol-eluting PLGA-based scaffold effectively restricts the growth of renal cancer cells. (harvard.edu)
  • Growth factors, signal transduction and cell cycle control. (ncl.ac.uk)
  • UltraCULTURE™ Medium can be used to support fusion of cells during hybridoma formation, growth of monocyte, macrophage, epithelial and fibroblastic cell lines, and generation of virus particles for vaccine production. (sartorius.com)
  • We previously found that transgenic mice overexpressing growth hormone (TGM) have elevated and progressively increasing free radical processes in brain that strongly correlates with reduced survivorship. (chiro.org)
  • Finally, in the absence of salt, cells depleted of FtsEX stopped dividing before any change in growth rate (mass increase) was apparent. (asm.org)
  • In Escherichia coli , the division septum forms via the coordinated inward growth of all three layers of the cell envelope-the cytoplasmic membrane, the peptidoglycan wall, and the outer membrane. (asm.org)
  • This receptor tyrosine kinase plays an integral role in cell growth, survival and anti-apoptotic processes. (ucl.ac.uk)
  • In the development and growth phases or during regeneration, stem cells provide backup and can generate sizeable amounts of daughter cells. (eurekalert.org)
  • Protein interactions between niche glial cells and the stem cells activate the Hippo signaling pathway in the stem cells to repress growth and cell division. (eurekalert.org)
  • The final component in this long series of signal sequences is the Yorkie effector protein that is the decisive factor at the end of the Hippo signaling pathway and determines the start of reactivation, growth, and division in the stem cells. (eurekalert.org)
  • Using the "organ-on-a-chip" technology, which relies on small three-dimensional devices mimicking the basic functions of human organs and tissues, the researchers demonstrated that both types of stem cells promoted neuronal growth. (innovations-report.com)
  • Dental stem cells produce specific molecules that are fundamental for the growth and attraction of neurons. (innovations-report.com)
  • In the adult organism cell migration is required for physiological processes such as angiogenesis and immune surveillance as well as pathological events such as tumor metastasis. (buenavidaestudio.com)
  • In the adult organism cell migration is restricted to cells that are required to traverse extracellular matrices during processes such as wound healing angiogenesis immune surveillance and malignancy metastasis. (buenavidaestudio.com)
  • MANIPULATION USING INDIRECT PUSHING Dictyostelium discoideum is used as a model organism to study collective cell migration =-=[28]-=- that is important in many biological processes from organ development to immune response to cancer metastasis. (psu.edu)
  • In other words, the activity of stem cells needs to be precisely regulated to meet the needs of an organism. (eurekalert.org)
  • Cold hardening is the physiological and biochemical process by which an organism prepares for cold weather. (wikipedia.org)
  • The BSE of B. physiological function of individual elements in the living organism. (scribd.com)
  • The model shows that the equilibrium concentration of a toxicant in an organism is the net result of gut cell death and replacement rates. (biomedsearch.com)
  • These epigenetic marks are established ("imprinted") in the germline (sperm or egg cells) of the parents and are maintained through mitotic cell divisions in the somatic cells of an organism. (wikipedia.org)
  • Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) in San Diego, CA, have found that a subtype of astrocytes - that is, star-shaped, non-neuronal brain cells that support the good functioning of neurons - play a key role in the early onset of brain inflammation. (medicalnewstoday.com)
  • Drosophila melanogaster offers the advantage that transgenes can be easily expressed in neuronal subpopulations, e.g., in intrinsic mushroom body neurons (Kenyon cells). (frontiersin.org)
  • A number of transgenes has been described and engineered to visualize the anatomy of neurons, to monitor physiological parameters of neuronal activity, and to manipulate neuronal function artificially. (frontiersin.org)
  • Axonal transport is the main process enabling fast delivery of organelles and biological molecules inside neurons. (ucl.ac.uk)
  • Neurotrophin (NT) signalling is of particular importance for large cells such as motor neurons. (ucl.ac.uk)
  • Recently, our lab discovered BICD1 motor adaptor protein as the key regulator of NT receptor sorting in embryonic stem cell-derived motor neurons (ES-MN). (ucl.ac.uk)
  • In order to do this, I will utilize both in vitro and in vivo models of ALS, including mouse models and neurons derived from patient induced pluripotent stem cells (iPSCs). (ucl.ac.uk)
  • However, little is known about the interactions between stem cells and neurons in regenerating tissues and in cancers. (innovations-report.com)
  • The first study compared the interaction of neurons with two different human stem cell populations, namely dental pulp stem cells and bone marrow stem cells. (innovations-report.com)
  • The dental pulp stem cells, however, yielded better results compared to bone marrow stem cells: They induced more elongated neurons, formed dense neuronal networks and established close contacts with nerves. (innovations-report.com)
  • They first demonstrated that ameloblastomas have stem cell properties and are innervated by facial neurons. (innovations-report.com)
  • These results create new possibilities for cancer treatment using drugs that modify the communication between neurons and cancer stem cells. (innovations-report.com)
  • The combination of advanced molecular and imaging tools and "organ-on-a-chip" technology offers an exciting opportunity to reveal the hidden functions of neurons and their interactions with various stem cell types, in both healthy and pathological conditions. (innovations-report.com)
  • Ameloblastomas exhibit stem cell potential, possess neurotrophic properties, and establish connections with trigeminal neurons. (innovations-report.com)
  • Currently, simple end-stopped and complex end-stopped cells are the terms of choice to describe neurons with end-stopping properties. (wikipedia.org)
  • Investigations into the localization of function as well as the advent of single-cell recordings of neurons fostered greater insights into the processing of information from sensation to perception. (wikipedia.org)
  • Raw single-walled carbon nanotube-induced cytotoxic effects in human bronchial epithelial cells: comparison to asbestos. (cdc.gov)
  • Different types of APC (like DC, B lymphoblastoid cells (BLC), thymic epithelial cells, monocytes) express individual patterns of active endocytic proteases and little is known about the rules that govern proteolysis of Ag in human DC. (jimmunol.org)
  • Our hypothesis is that during malignant transformation, breast epithelial cells undergo genomic amplification of the Sept9 locus and over-express Sept9 mRNA and protein. (yu.edu)
  • Based on published data, we have constructed a mechanistic model assuming a dynamic rate of replacement of epithelial cells with increasing contamination. (biomedsearch.com)
  • We use a population-type modeling, with a population of gut epithelial cells characterized by specific death and birth rates, which may change depending on the metal concentration in food. (biomedsearch.com)
  • In fact, it is possible that AhR could help modulate the balance between differentiation and pluripotency in normal and transformed tumor cells. (frontiersin.org)
  • YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing ß cells. (harvard.edu)
  • Consistent with this, an inverse correlation between CD99 expression and H-neurofilament expression, neural differentiation, and oncogenic transformation was observed in patient-derived EWS cells. (eurekalert.org)
  • CMA governs the balance between self-renewal and differentiation of ES cells. (pennmedicine.org)
  • We reveal two novel ways to potentially manipulate the self-renewal and differentiation of stem cells: CMA and a metabolite, known as alpha-ketoglutarate, that is regulated by CMA. (pennmedicine.org)
  • Using metabolomic and genetic laboratory techniques on the embryonic stem cells of mice, the researchers sought to better understand significant changes that took place during their pluripotent state and subsequent differentiation. (pennmedicine.org)
  • When it's time for differentiation, the cells begin to upregulate CMA due to the reduction in Oct4 and Sox2 . (pennmedicine.org)
  • This approach has the final goal of dissecting the molecular processes that mediate methylation changes in the morphogenesis and differentiation of the normal breast and to identify "hot spot" loci for gene silencing in breast carcinogenesis. (yu.edu)
  • Sleep is associated with significant genetic and epigenetic changes, suggesting the idea that its purpose is to regulate fundamental physiological and behavioural functions. (iit.it)
  • Examples from recent literature consider genetic engineering, sensory processes, and protection from biotic and abiotic stresses. (umass.edu)
  • Focus on evolutionary processes affecting the distribution of genetic variation through space and time: gene flow, genetic drift, recombination, mating system, mutation, and natural selection. (umass.edu)
  • Those imbalances arise as environmental inputs such as diet, nutrients (including air and water), exercise, and trauma are processed by one's body, mind, and spirit through a unique set of genetic predispositions, attitudes, and beliefs. (spineuniverse.com)
  • It is an epigenetic process that involves DNA methylation and histone methylation without altering the genetic sequence. (wikipedia.org)
  • Most take the form of a brief introduction followed by a discussion of the isolation and characterization of the mutants in question, and then by examples of how these mutants have been used to provide physiological insights. (bookdepository.com)
  • We further evaluated the role of Tks5 in neural crest cells and neural crest-derived tissues and found that loss of Tks5 impaired their ventral migration. (buenavidaestudio.com)
  • Migration of normal cells is usually most prominently found during embryogenesis where cells are required to move in 3-dimensional space to pattern the embryo and generate organs and tissues. (buenavidaestudio.com)
  • Recently, CGs have been described to induce inflammasome activation and pyroptosis in human macrophages, suggesting a cytotoxicity that remains to be elucidated in tissues.Experimental approach: To determine the cell type specificity of CG‐mediated cytotoxicity, we used human primary monocyte‐derived macrophages (hMDMs) and non‐adherent peripheral blood cells isolated from healthy donors. (imperial.ac.uk)
  • Monitoring the autophagic process and measuring autophagic flux in different tissues and organelles is critical to investigate the function of autophagy under specific stimuli. (taconic.com)
  • Stem cells can generate a variety of specific tissues and are increasingly used for clinical applications such as the replacement of bone or cartilage. (innovations-report.com)
  • However, stem cells are also present in cancerous tissues and are involved in cancer progression and metastasis. (innovations-report.com)
  • Therefore, these cells could represent an attractive choice for the regeneration of functional, properly innervated facial tissues," adds co-author and junior group leader Pierfrancesco Pagella. (innovations-report.com)
  • The major goal of this project is to explore a possible correlation between age-associated genome instability in a variety of tissues and functionality of these cells. (yu.edu)
  • These include intriguing instances of differing motif dosages and differing combinatorial motif control that promote regulatory specificity in rRNA metabolism under differing physiological processes. (nih.gov)
  • Among these were Ca 2+ metabolism-associated genes and further genes which are probably involved in transcriptional processes 2 . (uni-giessen.de)
  • The primary target for mechanical stimulation is the plasma membrane of the cell, which can respond to variable physical stress with changes of the open probability of mechanosensitive ion channels. (nih.gov)
  • Thus, acting on ion channels in the plasma membrane, mechanical stress can elicit a multitude of biochemical processes - both transient and long-lasting - inside a cell. (nih.gov)
  • Compared with nontransgenic cells, transgenic cells had greater plasma membrane permeability, less tolerance to NH 4 NO 3 , more tolerance to KNO 3 , and accumulated higher amounts of soluble protein. (usda.gov)
  • Why is the cell membrane so important? (brainscape.com)
  • The view that ftsEX affects cell division indirectly seems to have gained ascendancy, as most of the review articles on bacterial cell division published in the last 10 years make no mention of ftsE or ftsX (e.g., references 11 , 22 , and 31 ), and recent work in E. coli has explored potential connections to membrane protein insertion ( 10 , 37 ). (asm.org)
  • Calcium channels in the cell membrane detect the temperature drop, and promotes expression of low temperature responsible genes in alfalfa and arabidopsis. (wikipedia.org)
  • Cold increases cell membrane permeability and makes the cell shrink, as water is drawn out when ice is formed in the extracellular matrix between cells. (wikipedia.org)
  • To retain the surface area of the cell membrane so it will be able to regain its former volume when temperature rises again, the plant forms more and stronger Hechtian strands. (wikipedia.org)
  • To protect the cell membrane from expansion induced damage, the plant cell changes the proportions of almost all lipids in the cell membrane, and increases the amount of total soluble protein and other cryoprotecting molecules, like sugar and proline. (wikipedia.org)
  • Andre Herchuelz and Mordecai P. Blaustein are the authors of Sodium-Calcium Exchange and the Plasma Membrane Ca2+-ATPase in Cell Function: Fifth International Conference, Volume 1099, published by Wiley. (wiley.com)
  • When a cell swells due to external osmotic pressure, membrane channels open and allow efflux of osmolytes which carry water with them, restoring normal cell volume. (wikipedia.org)
  • However, at a functional level, lysosomal extracts from CD1c-DC processed the multiple sclerosis-associated autoantigens myelin basic protein and myelin oligodendrocyte glycoprotein in vitro more effectively than MO-DC. (jimmunol.org)
  • Laser manipulation and optical adhesion control of functional gel-microtool for on-chip cell manipulation - Maruyama, Fukuda, et al. (psu.edu)
  • Functional medicine uses the patient's story as a key tool for integrating diagnosis, signs and symptoms, and evidence of clinical imbalances into a comprehensive approach to improve the patient's physiological function. (spineuniverse.com)
  • LPL −/− mice exhibited a defective Ab response to Streptococcus pneumoniae , indicating a functional consequence of defective marginal zone B cell development in LPL −/− mice. (jimmunol.org)
  • The formation of such extended networks and the establishment of numerous contacts suggest that dental stem cells create functional connections with nerves of the face. (innovations-report.com)
  • We are currently studying how the expression of various Sept9 isoforms is regulated in normal and cancer cells and the functional differences between these isoforms. (yu.edu)
  • These results reveal an important and novel role for E-7050 (Golvatinib) the Src-Tks5 pathway in neural crest cell migration during embryonic development. (buenavidaestudio.com)
  • Translucently colored embryonic stem (ES) cell (upper right) and its differentiating derivatives (left and lower right). (pennmedicine.org)
  • All of them can be derived from embryonic stem (ES) cells, which relentlessly self-renew while retaining the ability to differentiate into any cell type in adult animals, a state known as pluripotency. (pennmedicine.org)
  • These findings reveal that CMA and alpha-ketoglutarate dictate the fate of embryonic stem cells. (pennmedicine.org)
  • Embryonic stem cells are often called pluripotent due to their remarkable ability to give rise to every cell type in the body, except the placenta and umbilical cord. (pennmedicine.org)
  • Embryonic stem cells not only provide a superb system to study early mammalian development, but also hold great promise for regenerative therapies to treat various human disorders. (pennmedicine.org)
  • Cell Physiological Processes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (sickkids.ca)
  • Exposure of BEAS-2B cells to SWCNT resulted in the phosphorylation of protein p42/44 (p42/44) and protein p38 (p38). (cdc.gov)
  • We demonstrate that activator protein 1 (AP-1) 'pioneers' the senescence enhancer landscape and defines the organizational principles of the transcription factor network that drives the transcriptional programme of senescent cells. (nature.com)
  • One protein that has been found to regulate malignancy cell invasion is the Src substrate and adaptor protein Tks5 (originally called Fish) [13]. (buenavidaestudio.com)
  • Several other rodent models have α-cell hyperplasia including mice with liver-specific deletion of either Gcgr or G s α protein ( 11 , 12 ). (diabetesjournals.org)
  • Individuals with a condition known as Chuvash polycythemia, which is caused by a specific mutation in the protein VHL, have a greater proportion of their blood volume occupied by red blood cells than do healthy individuals. (eurekalert.org)
  • Dram-2 interacts with central protein of autophagy LC3 to enhance autophagosome formation in DPN-mediated estrogen receptorβ activated autophagy in Hodgkin lymphoma (HL) cells. (taconic.com)
  • Fluorescence microscopy has undergone a resurgence in interest following the discovery of green-fluorescent protein (GFP) and its increasing use in live-cell imaging. (nih.gov)
  • Elucidating the role of BICD1 and its novel binding partner - protein tyrosine phosphatase, non-receptor type 23 (PTPN23) in this process is the main aim of my PhD project. (ucl.ac.uk)
  • In this article, we demonstrate the requirement for the actin-bundling protein L-plastin (LPL) in B cell motility toward the chemokines CXCL12 and CXCL13 and the lipid chemoattractant sphingosine-1-phosphate, which guide normal B cell development. (jimmunol.org)
  • L-plastin (LPL), an actin-bundling protein uniquely expressed in hematopoietic cells, is required for normal motility of T lymphocytes and for full T cell activation ( 4 , 5 ). (jimmunol.org)
  • Preliminary studies in our laboratory have shown mRNA for AMP-Activated Protein Kinase (AMPK) is expressed in the rat ovary in a cell-specific manner, and suggest roles of AMPK in regulating hormone production and cell viability. (calstatela.edu)
  • Immunohistochemical analyses of ACV/VI protein during ovarian development, ovulation, and luteinization revealed localized expression of ACV/VI in granulosa cells & oocytes of developing follicles, as well as cumulus cells of preovulatory follicles. (calstatela.edu)
  • The protein C pathway is localized to the endothelial cell surface and limits thrombin generation through negative feedback 4.2. (powells.com)
  • Osmolytes also interact with the constituents of the cell, e.g. they influence protein folding. (wikipedia.org)
  • This book shows how the study of fundamental plant physiological processes is being advanced through the science of genetics. (bookdepository.com)
  • Improving balance--in the patient's environmental inputs and in the body's fundamental physiological processes--is the precursor to restoring health and it involves much more than treating the symptoms. (spineuniverse.com)
  • Nerves are fundamental for regulating the physiological and regenerative processes involving stem cells. (innovations-report.com)
  • It appears that nerves are fundamental for the survival and function of cancer stem cells," explains Pagella. (innovations-report.com)
  • Interestingly the switch to a pro-migratory phenotype induced in neural crest cells through EMT and the generation of dendritic-like projections is similar to that used by invasive tumor cells during metastasis. (buenavidaestudio.com)
  • A metastasis map of human cancer cell lines. (harvard.edu)
  • The Hippo signaling pathway, which is highly conserved up to humans, was known to play a critical role in organ size determination, like, for example, in the liver, but has not been demonstrated to influence neural stem cells in the central nervous system. (eurekalert.org)
  • In diploid organisms (like humans), the somatic cells possess two copies of the genome, one inherited from the father and one from the mother. (wikipedia.org)
  • signal transduction processes during the development of the reproductive organs. (uni-giessen.de)
  • Nonlinear elastic and viscoelastic deformation of the human red blood cell with optical tweezers, Mechanics and chemistry of biosystems 1 - Mills, Qie, et al. (psu.edu)
  • Regenerative medicine replaces or regenerates human cells, tissue or organs, to restore or establish normal function. (ucl.ac.uk)
  • The multidisciplinary RegenMed Programme is focused on the bioprocess engineering aspects of stem cell and regenerative medicine translation including scale-up and scale-out. (ucl.ac.uk)
  • In addition to the substantial input from the faculty, the RegenMed Programme benefits from a large and growing number of external collaborators from both academia, healthcare professions and the regenerative medicine ("regen") industry, this multidisciplinary group is advancing the translation of the basic stem cell science into safe, clinically effective and affordable therapies for deployment in routine clinical practice. (ucl.ac.uk)
  • The RegenMed Programme is part of the newly established UCL Centre for Stem Cells and Regenerative Medicine. (ucl.ac.uk)
  • The impact of process stress on suspended anchorage-dependent mammalian cells as an indicator of likely challenges for regenerative medicines. (ucl.ac.uk)
  • The development of stem-cell based regenerative medicine therapies has rapidly increased in the last decade, with several approaches in studies shown to repair damaged heart tissue, replace cells in solid organ transplantation, and in some cases address neurological disorders. (pennmedicine.org)
  • Human bone marrow stem cells are isolated from skeletal bones and are the gold standard for bone regenerative approaches. (innovations-report.com)
  • More and more evidences have confirmed that miRNAs participate in diverse biological processes, which have a significant correlation with cancers [ 2 ]. (hindawi.com)
  • Overall, the collection of transgenic flies expressing sensor and reporter genes in Kenyon cells facilitates combinations with binary transcription systems and might, ultimately, advance the physiological analysis of mushroom body function. (frontiersin.org)
  • In WAT, we further explored the consequences of ouabain‐mediated cytotoxicity by measuring insulin sensitivity, adipose tissue function and extracellular matrix (ECM) deposition ex vivo.Key results: The ouabain‐induced cell death is through pyroptosis and apoptosis, and more efficient in hMDMs compared to non‐adherent PBMC populations. (imperial.ac.uk)
  • Just like regular maintenance extends the useful life of a car, exercise improves the function of many of the physiological systems responsible for optimal health. (acefitness.org)
  • The relation of cell, tissue, and organ microscopic structure to function. (umass.edu)
  • A study of the molecular processes which underlie cell structure and function, integrating ultrastructural, physiological and biochemical approaches. (sfu.ca)
  • Modern techniques used in the analysis of organelle and cell function are integral parts of the course. (sfu.ca)
  • The rate of progress in this field has been rapidly increasing, and new concepts have emerged regarding the relation between molecular structure and physiological function. (wiley.com)
  • Web-like interconnections of physiological factors -- an abundance of research now supports the view that the human body functions as an orchestrated network of interconnected systems, rather than individual systems functioning autonomously and without effect on each other. (spineuniverse.com)
  • Adjusting its physiological processes to keep functions within physiological limits at rest or during exercise. (prezi.com)
  • We apply our method to several yeast physiological processes: cell cycle, sporulation, and various stress conditions. (nih.gov)
  • however, it wasn't clear exactly how the cells' internal wiring works to keep that state and ultimately decide stem cell fate. (pennmedicine.org)
  • 2014). To continue with this work, a number of lab members are collaborating to investigate the receptor complex components, its transport dynamics and ultimately, the physiological role of internalised nidogen. (ucl.ac.uk)
  • Little, however, is known about how small changes in activity can regulate cell contractility, actin architecture and adhesion. (nature.com)
  • Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. (springer.com)
  • Furthermore, treating the mice with an MS drug called fingolimod reduced the number of these brain cells. (medicalnewstoday.com)
  • In the latter study, it was shown that mice lacking the gene for 5-LO are protected from aortic aneurysms ( 18 ), supporting that leukotrienes may exert their effects on vascular cells producing structural elements. (pnas.org)
  • Global Gcgr knockout mice ( Gcgr −/− ) have lower blood glucose than wild-type littermates but also develop hyperglucagonemia and α-cell hyperplasia ( 10 ). (diabetesjournals.org)
  • In the study, decreasing CD99 expression in human EWS cell lines reduced their ability to form tumors xenografted into mice. (eurekalert.org)
  • Entry of LPL −/− B cells into the lymph nodes and bone marrow of mice was also impaired. (jimmunol.org)
  • However, in 2004, experimental manipulation by Japanese researchers of a paternal methylation imprint controlling the Igf2 gene led to the birth of a mouse (named Kaguya) with two maternal sets of chromosomes, though it is not a true parthenogenone since cells from two different female mice were used. (wikipedia.org)
  • The Rh5 and Rh6 opsins are expressed in nonoverlapping sets of R8 cells and are the only Drosophila visual pigments that remain uncharacterized. (jneurosci.org)
  • Tissue topography steers migrating Drosophila border cells. (harvard.edu)
  • His work group has now been able to show how the resting phase is maintained in Drosophila neural stem cells. (eurekalert.org)
  • The National Cancer Institute (NCI) Surgery Branch has developed an experimental therapy for treating patients with metastatic cancer that involves taking white blood cells from the patient, growing them in the laboratory in large numbers, genetically modifying these specific cells with a type of virus (retrovirus) to attack only the tumor cells, and then giving the cells back to the patient. (clinicaltrials.gov)
  • The best strategy to prevent tumor remission should be the elimination of all kinds of aggressive cells within the tumor together with the bulk tumor cells since these cells have interconversion capacity and could originate new clones of CSCs or mesenchymal cell via the EMT process. (thefreedictionary.com)
  • Exposure of BEAS-2B cells to SWCNT induced apoptosis, DNA damage, and oxidative stress. (cdc.gov)
  • Local activation of RhoA not only stimulates local recruitment of actin and myosin but also increased traction forces that rapidly propagate across the cell via stress fibres and drive increased actin flow. (nature.com)
  • Stress presents a problem for dendritic cells: corticosterone and the fate of MHC class I antigen processing and presentation. (biomedsearch.com)
  • Increased sensitivity of the cells to mechanical stress is found under various pathological conditions. (nih.gov)
  • How cells respond to stress. (ncl.ac.uk)
  • Plant survival under HT stress depends on the ability to perceive the HT stimulus, generate and transmit the signal, and initiate appropriate physiological and biochemical changes. (mdpi.com)
  • This prediction is creating apprehension among scientists, as heat stress has known effects on the life processes of organisms, acting directly or through the modification of surrounding environmental components. (mdpi.com)
  • AMPK is an enzyme involved in protection of cells from metabolic stress, particularly in liver and skeletal muscle. (calstatela.edu)
  • Finally, it uses these genes to combat the stress, caused by sub-zero temperatures, affecting its living cells. (wikipedia.org)
  • The response to the change in calcium elevation depends on the cell type and stress history. (wikipedia.org)
  • Shoot tissue will respond more than a root cells, and a cell that already is adapted to cold stress will respond more than one that has not been through cold hardening before. (wikipedia.org)
  • Xyloglucan endotransglycosylase/hydrolase (XTH) is a cell-wall-modifying enzyme participating in diverse cell morphogenetic processes and adaptation to stress. (mdpi.com)
  • The invention relates to a process for continuously or intermittently determining the glucose concentration in subcutaneous tissue, which comprises using an enzymatic oxidation of glucose by oxygen in the presence of the enzyme glucose oxidase and determining the used amount of oxygen or the resultant amount of hydrogen peroxide by means of a measuring cell. (google.com)
  • The invention further relates to a system for continuously or intermittently determining the glucose concentration in subcutaneous tissue as well as to a measuring cell assembly suitable for use in this system and to an assembly for continuously or intermittently regulating the glucose concentration in blood. (google.com)
  • However, an increasing body of evidence from preclinical studies demonstrates that radiation and chemotherapy cause accumulation of senescent cells (SnCs) both in tumor and normal tissue. (imperial.ac.uk)
  • These results contribute to understanding how the endothelium can process large amounts of biochemical information for a coordinated, tissue-wide response. (sciencemag.org)
  • It has been shown that usually more than one isoform is expressed in a tissue or cell. (calstatela.edu)
  • Water in and between cells in the plant freezes and expands, causing tissue damage. (wikipedia.org)
  • This study examines the contribution of the two physiological types of neuron in layer 6, simple and complex, to the cortical microcircuit. (jneurosci.org)
  • A hypercomplex cell (currently called an end-stopped cell) is a type of visual processing neuron in the mammalian cerebral cortex. (wikipedia.org)
  • Dendritic cells (DC) initiate immunity and maintain tolerance. (jimmunol.org)
  • Dendritic cells (DC) 4 are a highly specialized APC. (jimmunol.org)
  • In this protocol, we are modifying the patients white blood cells with a retrovirus that has the gene for anti-mesothelin incorporated in the retrovirus. (clinicaltrials.gov)
  • The expression of either Rh5 or Rh6 in "blind" ninaE 17 mutant flies, which lack the gene encoding the visual pigment of the R1-R6 cells, fully rescues the light response. (jneurosci.org)
  • Glucagon, a 29-amino acid peptide derived from the preproglucagon gene, is produced by α-cells in the pancreatic islet. (diabetesjournals.org)
  • In addition, loss of preproglucagon gene expression or prohormone convertase 2 (PC2), the enzyme that liberates the mature glucagon peptide, results in α-cell hyperplasia ( 13 ). (diabetesjournals.org)
  • A number of mutant hunts, starting with the pioneering work of Hirota and coworkers in the 1960s, suggested that there is an important cell division gene located at about 76 min on the E. coli chromosome ( 30 ). (asm.org)
  • A new study finds a subtype of brain cell that is key in neuroinflammation, bringing us closer to new treatments for multiple central nervous system diseases. (medicalnewstoday.com)
  • 4. Describe the roles of different glia in the nervous system: astrocytes (astroglia), microglia, oligodendrocytes (oligodendroglia), Schwann cells. (majortests.com)
  • At the beginning of larval life, neural stem cells in the larval nervous system are naturally quiescent. (eurekalert.org)
  • My current research is directed towards understanding a remarkable epigenetic process termed "Genomic Imprinting" in which certain genes are silenced by epigenetic marks. (cardiff.ac.uk)
  • Genomic imprinting is an inheritance process independent of the classical Mendelian inheritance. (wikipedia.org)
  • This minireview provides an overview of the components of MHC class I antigen processing and presentation pathway and describes our recent published work on the effects of corticosterone on this process in virally infected DCs. (biomedsearch.com)
  • This discussion outlines important but often overlooked roles for glucagon that extend beyond glycemia and supports a new role for α-cells as amino acid sensors. (diabetesjournals.org)
  • One of the contributing factors for the increased knowledge of physiological roles of autophagy is availability of mouse models to study autophagy. (taconic.com)
  • ABC transporters use energy from ATP to transport a wide variety of substrates either into or out of cells (or subcellular compartments). (asm.org)
  • These changes enable E-7050 (Golvatinib) the cell to establish contacts with and directionally migrate through the extracellular matrix (ECM) in response to environmental stimuli [2]. (buenavidaestudio.com)
  • Tks5 was required for neural crest cell migration in vitro and both Src and Tks5 were required for the formation of actin-rich structures with similarity to podosomes. (buenavidaestudio.com)
  • During early development migratory cells undergo epithelial to mesenchymal transitions (EMT) which enable the generation of a mesenchymal phenotype to promote cell migration [4]. (buenavidaestudio.com)
  • These cells undergo EMT to enable delamination from your neural tube and subsequent migration to distant locations. (buenavidaestudio.com)
  • It has previously been shown that migrating neural crest cells form actin-rich dendritic-like protrusions which probe their surroundings and enable them to receive cues from neighboring neural crest cells E-7050 (Golvatinib) or the ECM to promote directional migration [11] [12]. (buenavidaestudio.com)
  • Collective cell migration in morphogenesis and cancer - Friedl, Hegerfeldt, et al. (psu.edu)
  • Hubel and Wiesel began recording cells in the cortex while presenting spots of light as stimuli. (wikipedia.org)
  • Serendipitously, Hubel and Wiesel had discovered that the cell was not responding to spots but to edges, namely the slide's shadow as it was placed into the projector. (wikipedia.org)
  • Hubel and Wiesel would later call this cell a complex cell, incorporating it into a hierarchy of subsequently discovered visual processing cells, which included the centre-surround, simple, complex, and hypercomplex cells (distinguishable by receptive fields) Following their initial finding, Hubel and Wiesel discovered the presence of a variety of visual processing cells, each with unique receptive field properties. (wikipedia.org)
  • We confirmed that these effects were likely to be cell autonomous by shRNA-mediated knockdown of Tks5 in a murine neural crest stem cell collection. (buenavidaestudio.com)
  • The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo. (harvard.edu)
  • This longevity of cells varies from approximately 120 days (for red blood cells) to 120 years (pluripotent stem cells * ), the current, approximate upper limit for human life span. (creation.com)
  • The new preclinical study, for the first time, shows how the stem cells keeps CMA at low levels to promote that self-renewal, and when the stem cell is ready, it switches that suppression off to enhance CMA, among other activities, and differentiate into specialized cells. (pennmedicine.org)
  • The minimal CMA activity allows stem cells to maintain high levels of alpha-ketoglutarate, a metabolite that is crucial to reinforce a cell's pluripotent state, the researchers found. (pennmedicine.org)
  • This newly discovered role of autophagy in the stem cell is the beginning of further investigations that could lead to researchers and physician-scientists to better therapies to treat various disorders," Yang said. (pennmedicine.org)
  • Neural stem cells (red) interact with their niche glial cells (green) to remain in quiescence. (eurekalert.org)
  • Neural stem cells are responsible for the formation of differentiated daughter cells in the developing brain. (eurekalert.org)
  • If no new cells are needed, the stem cells may enter a resting phase called quiescence. (eurekalert.org)
  • Stem cells are undifferentiated cells able to produce specialized cell types. (eurekalert.org)
  • Disruptions to the process can, in turn, result in tumor formation or early depletion of the stem cell reservoir. (eurekalert.org)
  • If no cell production is required, the stem cells remain in a quiescent state," explained Dr. Christian Berger of the Institute of Genetics at Mainz University. (eurekalert.org)
  • Once the larvae take up food, the stem cells are activated and begin to grow. (eurekalert.org)
  • Researchers at the University of Zurich show that different stem cell populations are innervated in distinct ways. (innovations-report.com)
  • They also demonstrate that cancer stem cells likewise establish contacts with nerves. (innovations-report.com)
  • Extracted teeth are the source of dental pulp stem cells, which represent a promising alternative. (innovations-report.com)
  • Therefore, stem cells are abundantly innervated," says Mitsiadis. (innovations-report.com)
  • In the second study, the researchers examined the interaction between nerves and cancer stem cells found in ameloblastoma, an aggressive tumour of the mouth. (innovations-report.com)
  • When ameloblastoma cells were isolated and placed in the "organ-on-a-chip" devices, they retained not only their stem cell properties but also attracted nerves and established contact with them. (innovations-report.com)
  • Human dental pulp stem cells exhibit enhanced properties in comparison to human bone marrow stem cells on neurites outgrowth. (innovations-report.com)
  • found that the coordinated behavior of endothelial cells in rat carotid artery resulted from communication between heterogeneous populations of cells with differential sensitivities to biochemical cues. (sciencemag.org)
  • It is the sensory interface for an enormous quantity of information about the chemical environment to which the vascular system is exposed and which provides cues on physiological status. (sciencemag.org)
  • In support of this hypothesis, the phosphorylation of Pyk-2, a tyrosine kinase that integrates chemotactic and adhesive cues, is diminished in LPL −/− B cells stimulated with chemokine. (jimmunol.org)
  • Tnfα induced autophagy play a critical role in induction of apoptosis/cell death in placental cells during pregnancy. (taconic.com)
  • Antonius Plagge, University of Liverpool: collaboration on the role of Xlas in neurodevelopmental processes. (iit.it)
  • To date, the physiological role of CMA remains unclear. (pennmedicine.org)
  • Finally, a well-characterized role of marginal zone B cells is the generation of a rapid humoral response to polysaccharide Ags. (jimmunol.org)
  • We have selected various candidates that we are currently investigating for their role in determining cell fate during mammary gland development and for their implication in breast tumorigenesis. (yu.edu)
  • While the catastrophic consequence of high levels of aneuploidy observed in abortions is self-explanatory, the role of aneuploidy under physiological conditions is a question waiting for answers. (yu.edu)
  • Tumor-derived proteinases and a possible physiological role for kallikrein-related peptidases (KLKs) as PAR regulators 2.3.6. (powells.com)
  • Their primary role is to maintain the integrity of cells by affecting the viscosity, melting point, and ionic strength of the aqueous solution. (wikipedia.org)
  • Glucose infusion: A salt solution with chemically modified glucose is infused I.V. over a period of from 12 to 48 hours, with subsequent donation of blood cells for blood and immune system studies. (clinicaltrials.gov)
  • Dr. Chun summarizes the team's findings, saying, 'We expected to see immune cells light up - but surprisingly, they weren't activated. (medicalnewstoday.com)
  • A total of 306 healthy full-time employees (141 women and 165 men), aged 22-69 (mean 36) years, provided a blood sample for the measurement of circulating immune (natural killer (NK), B, and total T) cells and NK cell cytotoxicity (NKCC) and completed a questionnaire survey during April to June 2002. (cdc.gov)
  • They activate naive T cells and are crucial for initiating an immune response and maintaining tolerance ( 1 , 2 ). (jimmunol.org)
  • Immune cell-derived proteinases and PARs 2.3.5. (powells.com)
  • R.F. Mueller, St James University Hospital, Leeds, Neuromuscular Disorders, Vol. 3, No. 4, 1993 'Although the author states that his objective is not to provide a complete account of plant physiological genetics, the coverage is broad, and shows a consistency which would not be found in a collection of reviews with the same scope. (bookdepository.com)
  • Although most examples are biased towards plants, basic similarities between all living eukaryotic cells (animal and plant) are recognized and used to best illustrate for students cell processes. (google.com)
  • Randy O. Wayne is a plant cell biologist at Cornell University notable for his work on plant development. (google.com)
  • He is an authority on how plant cells sense gravity through pressure, on the water permeability of plant membranes, light microscopy, as well as the effects of calcium on plant development. (google.com)
  • An increase in polyphenolic content could be attributed to a disruption of plant cell walls, providing better extractability, breaking chemical bonds of higher molecular weight polyphenols, and forming soluble low molecular weight polyphenols and their interconversion [1, 36, 37]. (thefreedictionary.com)
  • Endothelial cells lining blood vessels must sense, interpret, and respond to many different chemical signals. (sciencemag.org)
  • Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? (hindawi.com)
  • The same condition affects the research on endothelial progenitor cells (EPCs), creating more confusion than comprehension. (hindawi.com)
  • We show that CD1c-DC lack significant amounts of active cathepsins (Cat) S, L, and B as well as the asparagine-specific endopeptidase, the major enzymes believed to mediate MHC class II-associated Ag processing. (jimmunol.org)
  • Antigenic material is internalized into the endocytic compartment, where it undergoes proteolytic processing after exposure to reducing and hydrolyzing enzymes, before the proteolytic products form a complex with MHC class II molecules and are routed to the cell surface for the triggering of T cells. (jimmunol.org)
  • Enzymes other than thrombin that are potential physiological regulators of PARs 2.3.1. (powells.com)
  • The photoreceptor cells differ in their position within the ommatidium, their synaptic connections within the optic lobes of the brain, and the opsin genes they express. (jneurosci.org)
  • Because cell division genes are generally essential and because lesions in many housekeeping genes can affect cell division indirectly, there have not been any exhaustive screens for division mutants. (asm.org)
  • A variety of diagnostic, clinical, histopathological, and physiological assessments of retinal degeneration in patients are also included. (springer.com)
  • Two doctoral students in Kuffler's lab at Johns Hopkins University, David Hubel and Torsten Wiesel, were tasked with extending his work from retinal ganglion cells to the visual cortex. (wikipedia.org)
  • At the lowest and simplest level of the hierarchy are the aforementioned centre-surround cells of the retinal ganglion and LGN. (wikipedia.org)
  • Color discrimination requires the input of different photoreceptor cells that are sensitive to different wavelengths of light. (jneurosci.org)
  • In this study, we ectopically expressed Rh5 and Rh6 in the major class of photoreceptor cells (R1-R6) and show them to be biologically active in their new environment. (jneurosci.org)
  • Each ommatidium contains a bundle of 8 photoreceptor cells and 12 auxiliary cells. (jneurosci.org)
  • Included for the first time are presentations from all the principal laboratories involved in the field of visual prostheses-implant (chip) technology-in which investigations are targeted at restoring vision in eyes that have lost photoreceptor cells. (springer.com)
  • In activated, fast skeletal muscles of rabbit (psoas), frog (semitendinosus) and crayfish (walking leg flexor), we resolved at least three exponential rate processes. (springer.com)