Cellular processes, properties, and characteristics.
Physiological processes and properties of the DENTITION.
Properties and processes of the DIGESTIVE SYSTEM and DENTITION as a whole or of any of its parts.
Physiology of the human and animal body, male or female, in the processes and characteristics of REPRODUCTION and the URINARY TRACT.
Properties, and processes of the MUSCULOSKELETAL SYSTEM and the NERVOUS SYSTEM or their parts.
Functional processes and properties characteristic of the BLOOD; CARDIOVASCULAR SYSTEM; and RESPIRATORY SYSTEM.
The properties and relationships and biological processes that characterize the nature and function of the SKIN and its appendages.
Nutritional physiology related to EXERCISE or ATHLETIC PERFORMANCE.
Physiological processes, factors, properties and characteristics pertaining to REPRODUCTION.
The functions and properties of living organisms, including both the physical and chemical factors and processes, supporting life in single- or multi-cell organisms from their origin through the progression of life.
Nutritional physiology of adults aged 65 years of age and older.
Properties, functions, and processes of the URINARY TRACT as a whole or of any of its parts.
Processes and properties of the MUSCULOSKELETAL SYSTEM.
Biological properties, processes, and activities of VIRUSES.
Properties and processes of the DIGESTIVE SYSTEM as a whole or of any of its parts.
Physiological processes and properties of the BLOOD.
Nutritional physiology of children aged 13-18 years.
Processes and properties of the EYE as a whole or of any of its parts.
Characteristic properties and processes of the NERVOUS SYSTEM as a whole or with reference to the peripheral or the CENTRAL NERVOUS SYSTEM.
Physiological processes and properties of the RESPIRATORY SYSTEM as a whole or of any of its parts.
The functions of the skin in the human and animal body. It includes the pigmentation of the skin.
Nutrition of FEMALE during PREGNANCY.
The physiological processes, properties, and states characteristic of plants.
Physiological processes and properties of BACTERIA.
Processes and properties of the CARDIOVASCULAR SYSTEM as a whole or of any of its parts.
Nutrition of a mother which affects the health of the FETUS and INFANT as well as herself.
Nutritional physiology of children aged 2-12 years.
The processes and properties of living organisms by which they take in and balance the use of nutritive materials for energy, heat production, or building material for the growth, maintenance, or repair of tissues and the nutritive properties of FOOD.
Nutritional physiology of children from birth to 2 years of age.
An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.
Persons living in the United States having origins in any of the black groups of Africa.
Individual members of North American ethnic groups with ancient historic ancestral origins in Asia.
The study of natural phenomena by observation, measurement, and experimentation.
Persons living in the United States having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent.
Persons living in the United States of Mexican descent.
Persons living in the United States of Mexican (MEXICAN AMERICANS), Puerto Rican, Cuban, Central or South American, or other Spanish culture or origin. The concept does not include Brazilian Americans or Portuguese Americans.
The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
A plant genus of the family PRIMULACEAE that contains anagallosides, which are molluscacidal triterpenoid saponins.
Processes orchestrated or driven by a plethora of genes, plant hormones, and inherent biological timing mechanisms facilitated by secondary molecules, which result in the systematic transformation of plants and plant parts, from one stage of maturity to another.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.
Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Microbodies which occur in plant cells, and in some eukaryotic microorganisms, and which contain enzymes of the glyoxylate cycle. (Singleton and Stainsbury, Dictionary of Microbiology and Molecular Biology, 2nd ed)
Electron-dense cytoplasmic particles bounded by a single membrane, such as PEROXISOMES; GLYOXYSOMES; and glycosomes.
Microbodies which occur in animal and plant cells and in certain fungi and protozoa. They contain peroxidase, catalase, and allied enzymes. (From Singleton and Sainsbury, Dictionary of Microbiology and Molecular Biology, 2nd ed)
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
An organization of cells into an organ-like structure. Organoids can be generated in culture. They are also found in certain neoplasms.
A plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. The seed of Ricinus communis L. is the CASTOR BEAN which is the source of CASTOR OIL; RICIN; and other lectins.
A key enzyme in the glyoxylate cycle. It catalyzes the conversion of isocitrate to succinate and glyoxylate. EC

E-CELL: software environment for whole-cell simulation. (1/842)

MOTIVATION: Genome sequencing projects and further systematic functional analyses of complete gene sets are producing an unprecedented mass of molecular information for a wide range of model organisms. This provides us with a detailed account of the cell with which we may begin to build models for simulating intracellular molecular processes to predict the dynamic behavior of living cells. Previous work in biochemical and genetic simulation has isolated well-characterized pathways for detailed analysis, but methods for building integrative models of the cell that incorporate gene regulation, metabolism and signaling have not been established. We, therefore, were motivated to develop a software environment for building such integrative models based on gene sets, and running simulations to conduct experiments in silico. RESULTS: E-CELL, a modeling and simulation environment for biochemical and genetic processes, has been developed. The E-CELL system allows a user to define functions of proteins, protein-protein interactions, protein-DNA interactions, regulation of gene expression and other features of cellular metabolism, as a set of reaction rules. E-CELL simulates cell behavior by numerically integrating the differential equations described implicitly in these reaction rules. The user can observe, through a computer display, dynamic changes in concentrations of proteins, protein complexes and other chemical compounds in the cell. Using this software, we constructed a model of a hypothetical cell with only 127 genes sufficient for transcription, translation, energy production and phospholipid synthesis. Most of the genes are taken from Mycoplasma genitalium, the organism having the smallest known chromosome, whose complete 580 kb genome sequence was determined at TIGR in 1995. We discuss future applications of the E-CELL system with special respect to genome engineering. AVAILABILITY: The E-CELL software is available upon request. SUPPLEMENTARY INFORMATION: The complete list of rules of the developed cell model with kinetic parameters can be obtained via our web site at: http://e-cell.org/.  (+info)

Titrating the effects of mitochondrial complex I impairment in the cell physiology. (2/842)

The mitochondrial oxidative phosphorylation system consists of five multimeric enzymes (complexes I-V). NADH dehydrogenase or complex I (CI) is affected in most of the mitochondrial diseases and in some neurodegenerative disorders. We have studied the physiological consequences of a partial CI inhibition at the cellular level. We used a genetic model (40% CI-inhibited human-ape xenomitochondrial cybrids) and a drug-induced model (0-100% CI-inhibited cells using different concentrations of rotenone). We observed a quantitative correlation between the level of CI impairment and cell respiration, cell growth, free radical production, lipid peroxidation, mitochondrial membrane potential, and apoptosis. We showed that cell death was quantitatively associated with free radical production rather than with a decrease in respiratory chain function. The results obtained with human xenomitochondrial cybrid cells were compatible with those observed in rotenone-induced 40% CI-inhibited cells. At high concentrations (5-6-fold higher than the concentration necessary for 100% CI inhibition), rotenone showed a second toxic effect at the level of microtubule assembly, which also led to apoptosis. The correlation found among all the parameters studied helped clarify the physiological consequences of partial CI inhibitions at the cellular level.  (+info)

Workshop conclusions & recommendations.(3/842)


Time-resolved analysis and visualization of dynamic processes in living cells. (4/842)

Recent development of in vivo microscopy techniques, including green fluorescent proteins, has allowed the visualization of a wide range of dynamic processes in living cells. For quantitative and visual interpretation of such processes, new concepts for time-resolved image analysis and continuous time-space visualization are required. Here, we describe a versatile and fully automated approach consisting of four techniques, namely highly sensitive object detection, fuzzy logic-based dynamic object tracking, computer graphical visualization, and measurement in time-space. Systematic model simulations were performed to evaluate the reliability of the automated object detection and tracking method. To demonstrate potential applications, the method was applied to the analysis of secretory membrane traffic and the functional dynamics of nuclear compartments enriched in pre-mRNA splicing factors.  (+info)

Hyaluronan and proteoglycans in ovarian follicles. (5/842)

Proteoglycans are macromolecules formed by a protein backbone to which one or more glycosaminoglycan side chains are co-valently attached. They can be secreted by the cells, retained at the cell surface, or stored in intracellular vacuoles. Hyaluronan is an extremely long glycosaminoglycan which, at variance with other glycosaminoglycans, is released into the extracellular matrix as a free polysaccharide not co-valently linked to a core protein. Both proteoglycans and hyaluronan influence many aspects of cell behaviour by multiple interactions with other molecules. They are involved in matrix formation, cell-cell and cell-matrix adhesion, cell proliferation and migration, and show co-receptor activity for growth factors. Both proteoglycan and hyaluranon synthesis change significantly during ovarian follicle development and atresia. This review describes the structure of these molecules and their possible function in ovarian physiology.  (+info)

Modeling electroporation in a single cell. I. Effects Of field strength and rest potential. (6/842)

This study develops a model for a single cell electroporated by an external electric field and uses it to investigate the effects of shock strength and rest potential on the transmembrane potential V(m) and pore density N around the cell. As compared to the induced potential predicted by resistive-capacitive theory, the model of electroporation predicts a smaller magnitude of V(m) throughout the cell. Both V(m) and N are symmetric about the equator with the same value at both poles of the cell. Larger shocks do not increase the maximum magnitude of V(m) because more pores form to shunt the excess stimulus current across the membrane. In addition, the value of the rest potential does not affect V(m) around the cell because the electroporation current is several orders of magnitude larger than the ionic current that supports the rest potential. Once the field is removed, the shock-induced V(m) discharges within 2 micros, but the pores persist in the membrane for several seconds. Complete resealing to preshock conditions requires approximately 20 s. These results agree qualitatively and quantitatively with the experimental data reported by Kinosita and coworkers for unfertilized sea urchin eggs exposed to large electric fields.  (+info)

Modeling electroporation in a single cell. II. Effects Of ionic concentrations. (7/842)

This study expands a previously developed model of a single cell electroporated by an external electric field by explicitly accounting for the ionic composition of the electroporation current. The previous model with non-specific electroporation current predicts that both the transmembrane potential V(m) and the pore density N are symmetric about the equator, with the same values at either end of the cell. The new, ion-specific case predicts that V(m) is symmetric and almost identical to the profile from the non-specific case, but N has a profound asymmetry with the pore density at the hyperpolarized end of the cell twice the value at the depolarized end. These modeling results agree with the experimentally observed preferential uptake of marker molecules at the hyperpolarized end of the cell as reported in the literature. This study also investigates the changes in intracellular ionic concentrations induced around an electroporated single cell. For all ion species, the concentrations near the membrane vary significantly, which may explain the electrical disturbances observed experimentally after large electric shocks are delivered to excitable cells and tissues.  (+info)

The osmotic migration of cells in a solute gradient. (8/842)

The effect of a nonuniform solute concentration on the osmotic transport of water through the boundaries of a simple model cell is investigated. A system of two ordinary differential equations is derived for the motion of a single cell in the limit of a fast solute diffusion, and an analytic solution is obtained for one special case. A two-dimensional finite element model has been developed to simulate the more general case (finite diffusion rates, solute gradient induced by a solidification front). It is shown that the cell moves to regions of lower solute concentration due to the uneven flux of water through the cell boundaries. This mechanism has apparently not been discussed previously. The magnitude of this effect is small for red blood cells, the case in which all of the relevant parameters are known. We show, however, that it increases with cell size and membrane permeability, so this effect could be important for larger cells. The finite element model presented should also have other applications in the study of the response of cells to an osmotic stress and for the interaction of cells and solidification fronts. Such investigations are of major relevance for the optimization of cryopreservation processes.  (+info)

Ultra dense networks (UDN) are identified as one of the key enablers for 5G, since they can provide an ultra high spectral reuse factor exploiting proximal transmissions. By densifying the network infrastructure equipment, it is highly possible that each user will have one or more dedicated serving base station antennas, introducing the user-centric virtual cell paradigm. However, due to irregular deployment of a large amount of base station antennas, the interference environment becomes rather complex, thus introducing severe interferences among different virtual cells. This paper focuses on the downlink transmission scheme in UDN where a large number of users and base station antennas is uniformly spread over a certain area. An interference graph is first created based on the large-scale fadings to give a potential description of the interference relationship among the virtual cells. Then, base station antennas and users in the virtual cells within the same maximally-connected component are grouped
The question how living biological cells adapt their local or global mechanical properties when they have to move or deform, is intriguing and a field of intensive study worldwide.
Licet hoc documentum exscribere vel distribuere vel demutare sub GNU Liberarum Litterarum Licentiae conditionibus in editione 1.2 aut in ulla editione recentiori a Fundatione Liberarum Programmationis Partium publicata; praeterquam Sectiones Immutabiles et Verba Involucra Adversa et Aversa. Licentiae exemplar praesto est in sectione intitulata GNU Free Documentation License.http://www.gnu.org/copyleft/fdl.htmlGFDLGNU Free Documentation Licensetruetrue ...
The aim of CELLmicrocosmos is the interactive 3D stereoscopic visualization of biological cells for a better understanding of their internal structures and their functioning.
The aim of CELLmicrocosmos is the interactive 3D stereoscopic visualization of biological cells for a better understanding of their internal structures and their functioning.
Shop KESS InHouse The Magnolia Trees Outdoor Throw Pillow at Staples. Choose from our wide selection of KESS InHouse The Magnolia Trees Outdoor Throw Pillow and get fast & free shipping on select orders.
Through the Virtual Cell : A Closer Look The processes going on within our virtual cell occur at specific cellular locations. To emphasize the connections between these processes, the Closer Look section has been divided according the cellular organelles associated with the functions being illustrated. To see the Flash movie for the following sequences of images, click here.. ...
Here, we show that the multikinase inhibitor SO alone diminishes pancreatic CSC-like tumor cells, but depletes them significantly only in combination with the phytochemical SF. The major CSC characteristics of the CSChigh MIA-PaCa2 and CSClow BxPc-3 cell lines have been described in our recent study (6). In the present work, we describe the presence of two cell populations, which can be found in CSChigh but not in CSClow cells, namely, spheroidal cells and fibroblast-like adherent cells. These two populations may correspond to primitive CSCs and differentiated daughter cells, suggesting differentiation potential of in vitro cultured pancreatic CSCs. SO targeted both cell subpopulations present in the CSChigh cell line in vitro. This was due to the induction of apoptosis, DNA fragmentation, and downregulation of antiapoptotic proteins. In addition, SO strongly diminished clonogenicity, spheroid formation, and ALDH1 activity. Most importantly, the concentration of 20 μmol/L SO was selectively ...
Genome Project scientists say creating life-saving drugs isnt as easy as knowing all the genes in a human being -- they need a eureka technology to turn a mess into knowledge. Some are yelling Eureka! right now. By Kristen Philipkoski.
Honesty compels me to add that I was a member of the committee that wrote the current (1983) IUPAC-IUB Recommendations on Nomenclature and Symbolism for Amino Acids and Peptides, in which you will find, in Table 1, the words The systematic names and formulas given refer to hypothetical forms in which amino groups are unprotonated and carboxyl groups are undissociated. This convention is useful to avoid various nomenclatural problems but should not be taken to imply that these structures represent an appreciable fraction of the amino-acid molecules. I tried but failed to convince the rest of the committee that hypothetical was a euphemism that should be replaced by fictitious or nonexistent. After more than 30 years its hard to be certain, but I think the second sentence had not originally been in the draft but was added in an effort to keep me quiet. To be fair to the committee, I think the rest of the document shows correct structures, except for lapse with glutathione.. Delete ...
A tandem combinatorial reaction of four acyclic, colorless compounds (two α-aminoketones and two diones; one polar and one nonpolar for each) in aqueous solution (30 mM each, 60 °C, pH 7, 24 h) containing lipid vesicles and with or without quinones and solar illumination affords a distribution of up to 538 p
PDEBUG_CHAN(DFRAME, DEBUG_DEBUG, word %c - %s%s\n, (i & 1) ? b : a, text, (crc_a_ok[i % 5]) ? ok : BAD CRC ...
In this PhD, we present some algorithms and complexity results for two general problems that arise in the analysis of a metabolic network: the search for elementary modes of a network and the search for minimal precursors sets. Elementary modes is a common tool in the study of the cellular characteristic of a metabolic network. An elementary mode can be seen as a minimal set of reactions that can work in steady state independently of the rest of the network. It has therefore served as a mathematical model for the possible metabolic pathways of a cell. Their computation is not trivial and poses computational challenges. We show that some problems, like checking consistency of a network, finding one elementary mode or checking that a set of reactions constitutes a cut are easy problems, giving polynomial algorithms based on LP formulations. We also prove the hardness of central problems like finding a minimum size elementary mode, finding an elementary mode containing two given reactions, counting the
We consider a generic protocell model consisting of any conservative chemical reaction network embedded within a membrane. The membrane results from the self-assembly of a membrane precursor and is se
Ingredients reviewed for EmerginC Protocell Eye Cream to be 91% Top Allergen Free and free of Gluten, Nickel, Preservatives, Lanolin, and MCI/MI
PAOLO FRIL, chairman and chief scientific officer of GeneDupe, based in San Melito, California, is a man with a dream. That dream is a dragon in every home.. GeneDupes business is biotech pets. Not for Dr Fril, though, the mundane cloning of dead moggies and pooches. He plans a range of entirely new animals or, rather, of really quite old animals, with the twist that even when they did exist, it was only in the imagination.. Making a mythical creature real is not easy. But GeneDupes team of biologists and computer scientists reckon they are equal to the task. Their secret is a new field, which they call virtual cell biology . Biology and computing have a lot in common, since both are about processing information in one case electronic; in the other, biochemical. Virtual cell biology aspires to make a software model of a cell that is accurate in every biochemical detail. That is possible because all animal cells use the same parts list mitochondria for energy processing, the endoplasmic ...
Signals and Systems Telecom: Worldwide Cellular Network Operator KPIs of 29 pages is now available with MarketReportsHub.com at starting price of US$ 1000 for a single user PDF. Talk to us for other pricing options.
In this paper we summarize and discuss the modern technology and systems, studied and established by our research group, for performing the detection and special analysis incorporated with the super-h
Study Flashcards On BRS Phys 1 Cell Physiology at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
If it takes up space and has mass then it matters - actually it is matter. There are numerous terms that relate to the basic or fundamental unit of matter - the atom. ELEMENTS are pure substances which means that they consist of only one type of atom. A COMPOUND consists of two or more different kind of atoms or ions in definite proportions ...
Originally published in 1987, the purpose of this title was to develop a conceptual framework for understanding individual humans as complex, functional entitie
Free biology class materials on meiotic cell division, including a lecture PowerPoint, class notes, test questions, study guide & review questions.
Page contains details about transposase oligomers-encapsulated lipid-based nanoparticle-like protocells . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Academics from the University of Newcastle and HMRI have developed a revolutionary online platform to advance cancer research and treatment.
Population covered by mobile cellular network is the percentage of people that live in areas served by a mobile cellular signal regardless of whether they use it.This page has the latest values, historical data, forecasts, charts, statistics, an economic calendar and news for Population covered by mobile cellular network (%) in Sweden.
A team of researchers at Harvard University have modeled in the laboratory a primitive cell, or protocell, that is capable of building, copying and containing DNA.
I think about design principles a lot. Im such a nerd for design principles, I even have a collection. Im not saying all of the design principles in the collection are good - far from it! I collect…
Phys.org internet news portal provides the latest news on science including: Physics, Space Science, Earth Science, Health and Medicine
Several problems regarding cell motility and morphogenesis are characterized by the contemporary presence of cells that behave as single entities and cells that follow and cluster around them. From the mathematical point of view, describing such phenomena requires the development of mathematical models in which virtual cells can switch from a discrete to a continuous description. Keeping this in mind, the talk aims at presenting some ideas on how to do that, making for instance use of measure theory or introducing the concept of bubble functions ...
Technology Networks is an internationally recognised publisher that provides access to the latest scientific news, products, research, videos and posters.
Technology Networks is an internationally recognised publisher that provides access to the latest scientific news, products, research, videos and posters.
Research outputs, collaborations and relationships for Department of Cell Physiology and Metabolism, UNIGE published between 1 December 2019 - 30 November 2020 as tracked by the Nature Index.
A SON element which is operative to carry out at least two different SON functions is provided, wherein each of the SON functions is associated with at least one SON related action, and wherein a SON
Watch this video to learn how the XploRA™ from Horiba brings chemical identification directly to your microscope. The XploRA can be coupled to both upright and inverted microscopes, allowing analysis of all sample types, ranging from semiconductors and nano-materials, through to biological cells and tissues.
How did life originate? And can scientists create life? These questions not only occupy the minds of scientists interested in the origin of life, but also researchers working with technology of the future.. If we can create artificial living systems, we may not only understand the origin of life - we can also revolutionize the future of technology.. Protocells are the simplest, most primitive living systems, you can think of. The oldest ancestor of life on Earth was a protocell, and when we see, what it eventually managed to evolve into, we understand why science is so fascinated with protocells. If science can create an artificial protocell, we get a very basic ingredient for creating more advanced artificial life.. However, creating an artificial protocell is far from simple, and so far no one has managed to do that. One of the challenges is to create the information strings that can be inherited by cell offspring, including protocells. Such information strings are like modern DNA or RNA ...
Cell cycle models used in biology can be very complex. These models have parameters with initially unknown values. The values of the parameters vastly aect the accuracy of the models in representing real biological cells. Typically people search for the best parameters to these models using computers only as tools to run simulations. In this thesis methods and results are described for a computer program that searches for parameters to a series of related models using well tested algorithms. The code for this program uses ODRPACK for parameter estimation and LSODAR to solve the dierential equations that comprise the model ...
Parent Directory - childs_01.jpg 18-Nov-2015 13:10 37K childs_02.jpg 18-Nov-2015 13:10 30K childs_03.jpg 18-Nov-2015 13:10 29K childs_04.jpg 18-Nov-2015 13:10 32K childs_alone.html 18-Nov-2015 13:10 18K fullam_01.jpg 18-Nov-2015 13:10 45K fullam_02.jpg 18-Nov-2015 13:10 34K fullam_03.jpg 18-Nov-2015 13:10 19K fullam_straitjackets.., 18-Nov-2015 13:10 18K mairs_01.jpg 18-Nov-2015 13:10 31K mairs_02.jpg 18-Nov-2015 13:10 36K mairs_obit.html 18-Nov-2015 13:10 12K mairs_pullquote1.gif 18-Nov-2015 13:10 1.6K mckenna_01.jpg 18-Nov-2015 13:10 47K mckenna_02.jpg 18-Nov-2015 13:10 57K mckenna_pullquote1.gif 18-Nov-2015 13:10 3.1K mckenna_pullquote2.gif 18-Nov-2015 13:10 2.6K mckenna_trip.html 18-Nov-2015 13:10 19K nugent_01.jpg 18-Nov-2015 13:10 21K nugent_02.jpg 18-Nov-2015 13:11 32K nugent_pullquote1.gif 18-Nov-2015 13:11 4.1K nugent_pullquote2.gif 18-Nov-2015 13:11 5.0K nugent_pullquote3.gif 18-Nov-2015 13:11 2.9K nugent_segal.html 18-Nov-2015 13:11 28K ...
Recent experimental work in the field of synthetic protocell biology has shown that prebiotic vesicles are able to steal lipids from each other. This phenomenon is driven purely by asymmetries in the physical state or composition of the vesicle membranes, and, when lipid resource is limited, translates directly into competition amongst the vesicles. Such a scenario is interesting from an origins of life perspective because a rudimentary form of cell-level selection emerges. To sharpen intuition about possible mechanisms underlying this behaviour, experimental work must be complemented with theoretical modelling. The aim of this paper is to provide a coarse-grain mathematical model of protocell lipid competition. Our model is capable of reproducing, often quantitatively, results from core experimental papers that reported distinct types vesicle competition. Additionally, we make some predictions untested in the lab, and develop a general numerical method for quickly solving the equilibrium ...
The use of a combination of calibrated microbead populations with one or more calibrated biological cell populations to correct calibration of a flow cytometer for size and fluorescence intensity determinations of biological cell samples. The use of calibrated biological cells permits correction for factors related to the instrument and calibration microbeads so long as the excitation and emission spectra of the calibration microbeads, the calibration cells and the cell samples are all the same, respectively.
This article was originally published in UCLA Samueli Newsroom. Researchers at the UCLA Samueli School of Engineering have discovered a new artificial intelligence-based method to discern the properties of live biological cells without destroying them. The advance could enable laboratories to conduct drug-safety screening faster and more efficiently while improving quality control for cell therapies.. The research was published today in Natures Scientific Reports.. We want to know if a batch of live biological cells can be both viable and able to perform the functions we want them to. This noninvasive, AI-backed technique can infer the quality of those cells while keeping the entire batch intact, said study leader Neil Lin, an assistant professor of mechanical and aerospace engineering. We envision this method could be widely adopted by many academic and industrial cell biology labs. And it could be especially important in cell therapies, where the cells themselves are valuable.. Currently, ...
Living systems (humans) are complex. Changing just one thing is not possible. There are always unintended consequences, some perhaps good and other perhaps not so good.
It is also perfectly suitable for the disruption of biological cells as well as for DNA/RNA and protein extraction. With its high performance and great flexibility the mixer mill MM 400 is a unique product in the market. You may also be interested in the High Energy Ball Mill Emax, an entirely new type of mill for high energy input.. read more ...
دانلود کتاب راهنمای الکتروفیزیولوژی کلینیک مایو Mayo Clinic Electrophysiology Manual, 1ed is the first comprehensive guide to the electrical activity of biological cells and tissues and the techniques of elect
Alteration in charge means the membrane acts as a capacitor, with most cells having a resting potential 70-80mV lower than extracellular ...
Kevin G. Phillips, Angela M. Lee, Garth W. Tormoen, Rachel A. Rigg, Anand Kolatkar, Madelyn Luttgen, Kelly Bethel, Lyudmila Bazhenova, Peter Kuhn, Paul Newton, Owen J. T. McCarty ...
Get an answer for What hypothesis could you form to explain what would happen to the cell or organism if at least two cell structures were damaged or destroyed? and find homework help for other Science questions at eNotes
A sub-discipline of biology, its focus is in how organisms, organ systems, organs, cells, and biomolecules carry out the chemical or physical functions that exist in a living system.
O esperado é algo assim? [09-Nov-2017 04:51:35 UTC] hook http_request_args: 1510203095 [09-Nov-2017 04:51:46 UTC] hook… 2 months ago. ...
Newly formed protocell. Image 2 of 5. Artwork showing cellular components inside a basic cell membrane. This protocell (artificial cell) was formed from a synthetic primeval soup containing PNA (peptide nucleic acid, orange), fatty acids (blue) and lysosomes (enzyme-producing organelles, yellow). The primeval soup was a mix of carbon based molecules that chemically evolved to form simple cells, at the beginning of life. Scientists at Los Alamos National Laboratory in New Mexico, USA, attempted to recreate this in 2006 by making protocells. Here, the loose components have arranged themselves into an ordered structure resembling a simple cell. See G200/112-G200/116 for a series of images showing the creation of a protocell. - Stock Image G200/0113
TY - GEN. T1 - Separation of non-spherical biological cells with center of gravity offset by a shear flow. AU - Mikami, Fumihiko. AU - Tanishita, Kazuo. PY - 1995. Y1 - 1995. N2 - The numerical simulation of cell movement in a shear flow is performed to propose a new cell sorting method using a dumbbell model which describes non-spherical biological cells with center of gravity offset. A dumbbell is found to rotate or glide, depending on the center of gravity offset and the strength of shear flow. In rotating motion, the dumbbell rotates and falls vertically, accompanied by a periodical horizontal drift. In gliding motion, the dumbbell orients and glides in a fluid, where the gliding angle is determined by the center of gravity offset.. AB - The numerical simulation of cell movement in a shear flow is performed to propose a new cell sorting method using a dumbbell model which describes non-spherical biological cells with center of gravity offset. A dumbbell is found to rotate or glide, depending ...
If stochastic simulation of minimal cell models intrigues you, see may be interested in: Carletti T, Filisetti A.The stochastic evolution of a protocell: the gillespie algorithm in a dynamically varying volume.Comput Math Methods Med. 2012;2012:423627. Lazzerini-Ospri L, Stano P, Luisi P, Marangoni R.Characterization of the emergent properties of a synthetic quasi-cellular system.BMC Bioinformatics. 2012 Mar 28;13 Suppl 4:S9. Zachar I, Fedor A, Szathmáry E.Two different template replicators coexisting in the same protocell: stochastic simulation of an extended chemoton model.PLoS One. 2011;6(7):e21380. Epub 2011 Jul 19. Van Segbroeck S, Nowé A, Lenaerts T.Stochastic simulation of the chemoton.Artif Life. 2009 Spring;15(2):213-26. | Origin of Life: Emergence, Self-organization and Evolution
Title: Stochastic analysis of biochemical reaction networks with absolute concentration robustness Abstract: It has recently been shown that structural conditions on the reaction network, rather than a fine-tuning of system parameters, often suffice to impart absolute concentration robustness on a wide class of biologically relevant, deterministically modeled mass-action systems [Shinar and Feinberg, Science, 2010]. Many biochemical networks, however, operate on a scale insufficient to justify the assumptions of the deterministic mass-action model, which raises the question of whether the long-term dynamics of the systems are being accurately captured when the deterministic model predicts stability. I will discuss recent results that show that fundamentally different conclusions about the long-term behavior of such systems are reached if the systems are instead modeled with stochastic dynamics and a discrete state space. Specifically we characterize a large class of models which exhibit ...
Artificial cells communicate and cooperate like biological cells, ants (w/ Video): Inspired by the social interactions of ants and slime molds, University of Pittsburgh engineers have designed artificial cells capable of self-organizing into independent groups that can communicate and cooperate. ...
Living Systems has seven units -- The Nature of Biology, Energy and the Cell, The Continuation of Life, Evolutionary Relationships, Life Functions of Organisms, Controlling Living Systems and Interactions in the Environment. Those are nice titles, but they give only a poor idea of the books content, and they dont convey what the book really is about. At bottom, Living Systems is a book about humans. Indeed, I suspect that it may have originated as an attempt to get some new mileage out of a mass of old material that dealt with human anatomy and physiology. Sure, the book mentions other organisms, and the paste-pushers have thrown in some chapters that purport to tell about evolution and ecology and what-have-you, but the result is silly. The material about evolution and ecology is hopelessly dumb and does little to divert attention from the books anthropocentric stance, and I doubt that anyone who really reads Living Systems will mistake it for a general-biology text. Its ...
A GPS Based Deterministic Channel Allocation for Cellular Network in Mobile Computing: 10.4018/978-1-60566-986-1.ch104: The scarcity of the radio channel is the main bottleneck toward maintaining the quality of service (QoS) in a mobile cellular network. As channel allocation
The concept of identity is used both (i) to distinguish a system as a particular material entity that is conserved as such in a given environment (token-identity: i.e., identity as permanence or endurance over time), and (ii) to relate a system with other members of a set (type-identity: i.e., identity as an equivalence relationship). Biological systems are characterized, in a minimal and universal sense, by a highly complex and dynamic, far-from-equilibrium organization of very diverse molecular components and transformation processes (i.e., genetically instructed cellular metabolisms) that maintain themselves in constant interaction with their corresponding environments, including other systems of similar nature. More precisely, all living entities depend on a deeply convoluted organization of molecules and processes (a naturalized von Neumann constructor architecture) that subsumes, in the form of current individuals (autonomous cells), a history of ecological and evolutionary interactions (across
To achieve ideal timelines, you must accelerate every individual function and handoff utilizing a precise blend of innovative technologies, proven strategies and exceptional project management. The right combination will enable you to successfully go from transfection to IND in less than 12 months. This ambitious goal requires a true team effort from every department.. Speed to IND for Biologics, the first event in CBIs Bioprocessing Series, provides a comprehensive, cross-functional format that brings together experts from every department to share their perspectives, achievements and lessons learned as a community working towards the common goal of accelerating speed while managing and mitigating risk.. With 32 expert presenters, 20 case studies/new data presentations and just two days out of the office, you wont want to miss this first-of-its-kind event!. ...
Cellular Physiology and Biochemistry is a multidisciplinary scientific forum dedicated to advancing the frontiers of basic cellular research. It addresses scientists from both the physiological and bi
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Presentation November 2008 on Systems Architecture, the methodological and conceptual background to Living Architecture & Protocell Architecture
Medical researchers might realize a range of breakthroughs if they could look deep inside living biological cells, but existing methods for imaging either
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philipbeesleyarchitect.com A new art installation at Espace EDF Fondation uses biomimetic components made from materials more associated with industrial
In Nature, cells and tissues assemble and organize themselves within a matrix of protein fibers that ultimately determines their structure and function, such as the elasticity of skin and the contractility of heart tissue. ...
Cell Structure and Function: Questions 299-307 of 413. Get to the point NEET (NTA-National Eligibility cum Medical Entrance Test) Biology questions for your exams.
Enzymes are a group of complex proteins or conjugated proteins that are produced by living cells and act as catalysts in specific biochemical reactions.
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A physiological change in the cells must have occurred to allow this phenomenon. Low salinity is desirable for survival, as ... Also, availability of silicates, a nutrient for the organism, can affect photosynthetic efficiency and cell composition. ...
A new physiological phenomenon of Desired Metaplasia for regeneration of tissues and organs in vivo. Annals of NYAS 1998. Bynum ... 2016 - The first ever artificial pancreas was created 2019 - 3D-print heart from human patient's cells. Timeline of antibiotics ... Matapurkar B G. (1995). US international Patent 6227202 and 20020007223.medical use of Adult Stem cells. ... Adult stem cell use in regeneration of tissues and organs in vivo - B. G Matapurkar U.S . International Patent 1996 - Dolly the ...
... refers to a phenomenon for which the orientation of cells and stress fibers is influenced by geometrical ... on the surface with nano-micro-groove-like pattern and cell physiological effects". Chinese Science Bulletin. 54 (18): 3200- ... A similar effect can be obtained when cells are cultured on flat surfaces with lines of proteins printed on top (to which cells ... The Interplay Among Cell Traction, Fibrillar Network Deformation, Fibril Alignment, and Cell Contact Guidance". Journal of ...
... a strange phenomenon was observed. Binding interactions between the white blood cells and the vessel walls were observed to ... This topic was finally able to be studied thoroughly under physiological shear stress conditions using a typical flow chamber.[ ... "Microfluidic devices for modeling cell-cell and particle-cell interactions in the microvasculature". Microvascular Research. 82 ... For a catch-bond, the force on the cell pulls the adhesive tip of a fimbria to close tighter on its target cell. As the ...
These are cells unspecific resistance modulation and influencing the speed of physiological processes occurring in the cell. ... Because of universality of this phenomenon it was named "the law of intermittent activity of functioning structures" ( ... Regulation of tissue cell mass by the TAS mechanism can be carried out in two physiological regimes - ether by formation of " ... Meanwhile, the cell stress concept considers only the first possibility. At the present moment, two physiological functions of ...
When skin is stretched beyond its physiological limit, mechanotransduction pathways are activated. This leads to cell growth as ... Other biological phenomena such as tissue inflammation can also be considered expansion (see tissue inflammation below). Skin ... Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and ... well as to the formation of new cells. In some cases, this may be accomplished by the implantation of inflatable balloons under ...
The bottleneck exploits stochastic processes in the cell to increase in the cell-to-cell variability in mutant load as an ... When this occurs, it is known as reaching threshold, and it usually results in physiological consequences. Symptoms of severe ... An example of this phenomenon is Leber optic atrophy. Generally, individuals with this condition do not experience vision ... Many cell divisions and a great deal of time are required for a cell to accumulate enough mutant mitochondria to cause symptoms ...
Examples of physiological regeneration are the continual replacement of cells of the skin and repair of the endometrium after ... In order to prevent starvation a planarian will use their own cells for energy, this phenomenon is known as de-growth.[42] ... Macrophages are a type of repairing cell that devour dead cells and pathogens, and trigger other immune cells to respond to ... First, adult cells de-differentiate into progenitor cells which will replace the tissues they are derived from.[56][57] Second ...
A DamID protocol for single cells has also been developed and applied to human cells. Single cell approaches can highlight the ... The targeted DamID (TaDa) approach uses the phenomenon of ribosome reinitiation to express Dam-fusion proteins at appropriately ... This allows for investigation into developmental or physiological processes in animal models. ... "Genome-wide maps of nuclear lamina interactions in single human cells". Cell. 163 (1): 134-147. doi:10.1016/j.cell.2015.08.040 ...
J Neurol 254(2):257-258 Rüdel, R; Lehmann-Horn, F (1985). "Membrane changes in cells from myotonia patients". Physiological ... This phenomenon was described along with the disease by Thomsen in 1876 but its etiology remains unclear.[citation needed] ... Trip J, Faber CG, Ginjaar HB, van Engelen BG, Drost G (2007) Warm-up phenomenon in myotonia associated with the V445M sodium ... There have been several proposed mechanisms for this phenomenon, but none have been conclusive; one theory is that the Na+/K+- ...
In: Botanical and physiological memoirs…, 1853: The phenomenon of rejuvenescence in nature, especially in the life and ... He translated: On Vegetable Cells, by Carl von Nägeli; for the Ray Society, 1846. Chemical Field Lectures, by Julius Adolph ... Outlines of Structural and Physiological Botany, 1847. Reports and Papers on Botany, Ray Society, 1849. The Rudiments of Botany ... Principles of the Anatomy of the Vegetable Cell, by Hugo von Mohl, 1851. ...
... have become iconic medical and physiological textbook images of these phenomena. Another major research interest was the ... His work developed to address the permeation of potassium ions in muscle cells. During a Rockefeller travelling scholarship in ... "An interview with Otto Hutter" (PDF). Physiological Society. Retrieved 29 July 2015. CS1 maint: discouraged parameter (link) ... Physiological Reports. 5 (6): e13165. doi:10.14814/phy2.13165. ISSN 2051-817X. PMC 5371556. PMID 28320898. The Guardian, ...
Nephron remodeling increases the number of distal convoluted cells, principle cells, and intercalated cells. These cells have ... Prolonged usage of loop diuretics will also contributes to resistance through "braking phenomenon". This is the body ... physiological response to reduced extracellular fluid volume, where renin-angiotensin-aldosterone system will be activated ... Loop diuretics also inhibits NKCC2 at macula densa, reducing sodium transported into macula densa cells. This stimulates the ...
He also worked extensively on developing accurate methods to measure blood pressure and other physiological phenomena (e.g. ... J Mol Cell Cardiol. 22 (3): 253-277. doi:10.1016/0022-2828(90)91459-K. PMID 2192068. Norman Sharpe (2006). "Hypertension: from ... This law states that "Within physiological limits, the force of contraction is directly proportional to the initial length of ... J Mol Cell Cardiol 1990; 22: 253-277) Kritik der elastischen Manometer, 1903 Die Registrierung des Pulses durch einen ...
Additional work by the Schwartz group has shown that protective autoimmunity is a naturally occurring physiological phenomenon ... Other cell types, such as B cells and even neural progenitor cells, can promote regulation of immune response in the CNS. Stem ... a population of CNS-resident immune cells, which can act as phagocytes, and antigen-presenting cells. CD4+ T helper cells that ... dictate the profile of the subsequent T cell response. The interaction between the T cells and the microglia/dendritic cells ...
This phenomenon is referred to as stem cell transdifferentiation or plasticity. It can be induced by modifying the growth ... There is yet no consensus among biologists on the prevalence and physiological and therapeutic relevance of stem cell ... these cells have the same ability as embryonic stem cells to develop into many different cell types. Olfactory stem cells hold ... such as mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, etc.). A great deal of adult stem cell ...
Part of the sperm's cell membrane then fuses with the egg cell's membrane, and the contents of the head sink into the egg. In ... This is referred to as spontaneous acrosome reaction (SAR). It is now known that in a certain sense, this phenomenon is ... In humans, on the other hand, it remains disputed where exactly the acrosome reaction is initiated in physiological ... It is then expressed as a percentage of the counted cells. For assessment with flow cytometry, the washed cells are incubated ...
Stimulation of autophagy in infected cells can help overcome this phenomenon, restoring pathogen degradation. ... and that the process was not limited to injury states that functioned under physiological conditions for "reutilization of ... Mechanism of cell death[edit]. Cells that undergo an extreme amount of stress experience cell death either through apoptosis or ... "Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells". ...
Stimulation of autophagy in infected cells can help overcome this phenomenon, restoring pathogen degradation. ... and that the process was not limited to injury states that functioned under physiological conditions for "reutilization of ... Mechanism of cell death[edit]. Cells that undergo an extreme amount of stress experience cell death either through apoptosis or ... Mizushima N, Komatsu M (November 2011). "Autophagy: renovation of cells and tissues". Cell. 147 (4): 728-41. doi:10.1016/j.cell ...
Among the phenomena he investigated were nerve compression, plasmolysis in cartilage cells, the electrical conductivity of ... he worked at the physiological institute in Bucharest. Călugăreanu founded Știința tuturor ("Science for All") magazine in 1918 ... a professor at Bucharest's higher school of veterinary medicine from 1902 to 1905 and an associate professor of physiological ...
In many species it has been demonstrated that HSPs results in improved physiological phenomena such as photosynthesis, ... Similar analogy in human medical terms is high blood pressure or high body temperature or high white blood cells in body is an ... Evaluating physiological traits to complement empirical selection for wheat in warm environments. Euphytica 100:84-95., Fokar, ... At very high temperatures cause severe cellular injury and cell death may occur within short time, thus leading to a ...
During stationary growth phase when B. subtilis are at high cell density, approximately 10% of the cells in a population are ... This phenomenon was termed "autoinduction" because it involved a molecule (autoinducer) that accumulated in a growth medium and ... Sporulation, on the other hand, is a physiological response of B. subtilis to depletion of nutrients within a particular ... Dunny, G.M.; Leonard, B.A. (1997). "Cell-cell communication in gram-positive bacteria". Annu. Rev. Microbiol. 51: 527-564. doi: ...
Examples of physiological regeneration are the continual replacement of cells of the skin and repair of the endometrium after ... In order to prevent starvation a planarian will use their own cells for energy, this phenomenon is known as de-growth. Limb ... Second, the blastemal cells will undergo cell proliferation, patterning, cell differentiation and tissue growth using similar ... Macrophages are a type of repairing cell that devour dead cells and pathogens, and trigger other immune cells to respond to ...
This technique is important to many cell biological and physiological studies during the demonstration of a relationship ... are located in the same area of the cell or very near to one another. The definition can be split into two different phenomena ... coincident detection of zinc accumulation and propidium iodide (a traditional cell death indicator) uptake in multiple cell ... Cell. 148 (4): 635-637. doi:10.1016/j.cell.2012.01.018. PMC 3479156. PMID 22341441. Zinchuk, V; et al. (2013). "Bridging the ...
These fluxes reveal information about physiological phenomena. Each NMT flux sensor is selective or specific for a particular ... Cell. 160 (6): 1209-1221. doi:10.1016/j.cell.2015.01.046. PMID 25728666. Degenhardt, J.; Larsen, P.B.; Howell, S.H.; Kochian, L ... Combining two particular flux measurements simultaneously can be a strong indicator of physiological phenomena. For example, ... salt gland cells, mesophyll cells, and condensed organelles like chloroplasts and vacuoles. NMT can help identify plants that ...
He investigates how phenomena such as dendritic integration may allow individual neurons and small neural networks to perform ... His main interest is in the computational capabilities of individual nerve cells in the cerebral cortex and basal ganglia. He ... Thus, it also deals with the application and development of physiological and optical techniques that enable the acquisition of ... Understanding such computational properties requires the simultaneous acquisition of data from multiple cells in a network in ...
"A study of the germ cells of certain Diptera with reference to the heterochromosomes and the phenomena of synapsis". J Exp Zool ... The physiological relevance of transvection has been, recently, documented in the context of sex-biased gene expression. In ... Transvection is an epigenetic phenomenon that results from an interaction between an allele on one chromosome and the ... pairing-mediated phenomena have been observed in species other than Drosophila, including mice, humans, plants, nematodes, ...
The term osmosis originated in 1827 and its importance to physiological phenomena realized, but it wasn't until 1877, when the ... Heredity information (DNA) is passed on from cell to cell. All cells have the same basic chemical composition. The cell was ... All known living things are made up of one or more cells All living cells arise from pre-existing cells by division. The cell ... All cells arise only from pre-existing cells However, the idea that all cells come from pre-existing cells had in fact already ...
... , (born 1928 in Uttarpara near Calcutta), is a scientist, investigating physiological phenomena in plants and ... Naturforschung 36c,884-887, 1981 Mayee, C.D. & Sarkar, S.: The ultrastructure of Nicotiana tabacum cells infected with potato ... Physiological studies on diploid and polyploid varieties of banana. Science and Culture 16, 215,1950 Sarkar, S.: Versuche zur ... Cellwall-free protoplasts of plant cells (mainly of tobacco and Chinese cabbage) were infected with viruses or with their RNA ...
Outer hair cells serve as acoustic amplifiers for stimulation of the inner hair cells. Outer hair cells respond primarily to ... A natural physiological reaction to these threshold shifts is vasoconstriction, which will reduce the amount of blood reaching ... Listener fatigue (also known as listening fatigue or ear fatigue) is a phenomenon that occurs after prolonged exposure to an ... "J. Cell Biol. 164 (6): 887-97. doi:10.1083/jcb.200310055. PMC 2172292. PMID 15024034.. ...
... has been known to stimulate cell growth in normal and cancer cell line cultures,[37] and it was shown that ... With the exception of chemotherapy-induced nausea and vomiting, the patho-physiological basis of many of the disease groups ... "Elevated CSF levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia: new features for ... on cells (including cancer cells) bestowing upon them mobility.[40] and metastasis.[41] It has been suggested that cancer ...
Potassium is the major cation (positive ion) inside animal cells,[223] while sodium is the major cation outside animal cells.[ ... the minimum physiological requirement for sodium is 500 milligrams per day.[225] Sodium chloride (also known as common salt) is ... and electron correlative contributing phenomena.[161] While analogous lithium bonds are also known, they are mostly ... The balance between potassium and sodium is maintained by ion transporter proteins in the cell membrane.[231] The cell membrane ...
The principles behind the equation are considered useful for explaining physiological phenomena happening at the capillary such ... Where the endothelial glycocalyx overlies an inter endothelial cell cleft, the plasma ultrafiltrate may pass to the ...
... only one cell released into the environment could exponentially grow into many thousands of cells over a short amount of time. ... Invasion of long-established ecosystems by organisms from distant bio-regions is a natural phenomenon, which has likely been ... "Pseudo-nitzschia physiological ecology, phylogeny, toxicity, monitoring and impacts on ecosystem health". Harmful Algae. 14: ... For organisms between 10 and 50 microns, such as certain types of phytoplankton, current regulations allow less than 10 cells ...
This idea, that electrical synapses couple groups of cells into functional units, lead to Bullock's lifelong interest in field ... One colleague described Bullock as an "adventurous scientific explorer, continually seeking undiscovered phenomena and new ... both at the physiological and behavioral level. During this time, the importance of comparative studies also became apparent to ... physiological, and chemical) were relevant to observed differences in species-specific traits, as well as which specific traits ...
The hair cells in the cochlea release neurotransmitter as a result, causing action potentials down the auditory nerve. The ... Johnson, P. B.; Ferraina, S.; Bianchi, L.; Caminiti, R. (1996). "Cortical networks for visual reaching: physiological and ... An example is the phenomenon of tapping to the beat, where the listener anticipates the rhythmic accents in a piece of music. ... however it is often found that cells in primary and non-primary auditory cortex have spatio-temporal receptive fields, rather ...
"for their discovery of جی پروتئینs and the role of these proteins in ورارسانی پیام in cells"[۷۳] ... "for his method of reproducing colours photographically based on the phenomenon of interference"[۸۳] ... "for their discoveries concerning the primary physiological and chemical visual processes in the eye"[۵۶] ... "for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell"[۶۱] ...
cell-cell signaling. • positive regulation of brain-derived neurotrophic factor receptor signaling pathway. • collateral ... Heinonen I, Kalliokoski KK, Hannukainen JC, Duncker DJ, Nuutila P, Knuuti J (November 2014). "Organ-specific physiological ... a phenomenon which is partly responsible for exercise-induced neurogenesis and improvements in cognitive function.[14][21][22][ ... regulation of protein localization to cell surface. • regulation of receptor activity. • activation of phospholipase C activity ...
... beginning with cleaning out their own cell after eating through their capped brood cell): feed brood, receive nectar, clean ... Karasov, William H.; Martinez del Rio, Carlos (2008). Physiological Ecology: How Animals Process Energy, Nutrients, and Toxins ... This relationship leads to a phenomenon known as "worker policing". In these rare situations, other worker bees in the hive who ... Eggs are laid singly in a cell in a wax honeycomb, produced and shaped by the worker bees. Using her spermatheca, the queen can ...
... of cells in the cell cycle.[253]. *Mark Oliphant (1901-2000): Australian physicist and humanitarian. He played a fundamental ... Several structures and phenomena in anatomy and physiology are named for him, including the Golgi apparatus, the Golgi tendon ... Hermann Joseph Muller (1890-1967): American geneticist and educator, best known for his work on the physiological and genetic ... She is the George Barth Geller Professor of Research in Molecular Biology and Chair of the Department of Cell Biology at Duke ...
2004). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197- ... Planque S, Nishiyama Y, Taguchi H, Salas M, Hanson C, Paul S (June 2008). "Catalytic antibodies to HIV: Physiological role and ... "The Duesberg Phenomenon: A Berkeley virologist and his supporters continue to argue that HIV is not the cause of AIDS. A 3- ... Wood E, Hogg RS, Yip B, Harrigan PR, O'Shaughnessy MV, Montaner JS (2003). "Is there a baseline "சி.டி.4" cell count that ...
The mental entities transcend the physiological just as the physiological transcends the molecular, the molecular, the atomic ... The methodology of science is physicalist, in that inquiry assumes phenomena can be described physically. Segueing to #re_10, ... cells, entire organisms, or minds). These systems are so complex that they can't feasibly be rewritten without tremendous ... it is not even a physiological function of the brain, nor is it a state of the brain at all. (Avenarius 1891, 76). Mach ...
The branch of biology that studies the structure and function of living cells, including their physiological properties, ... The phenomenon occurs naturally but is also frequently mimicked in industry and engineering.. crista. A fold in the inner ... cell membrane. The semipermeable membrane surrounding the cytoplasm of a cell.. cell nucleus. The "control room" for the cell. ... cell plate. Grown in the cell's center, it fuses with the parental plasma membrane, creating a new cell wall that enables cell ...
Neurons are cells specialized for communication. They are able to communicate with neurons and other cell types through ... The morphology, molecular identity, and physiological characteristics of neurons and how they relate to different types of ... Although many studies still hold a reductionist stance looking for the neurobiological basis of cognitive phenomena, recent ... These questions include how signals are processed by neurites - thin extensions from a neuronal cell body, consisting of ...
... its action is to hyperpolarize vascular smooth muscle cells, causing these cells to relax, thus allowing the blood vessel to ... Although the phenomenon of EDHF has been observed and reported in scientific literature, to date the chemical identity of the ... It implies a reasonable physiological sense, although to some extent and when EDHF acts as backup mechanism for endothelium- ... Cell. Cardiol. 39 (5): 725-32. doi:10.1016/j.yjmcc.2005.07.007. PMID 16122755.. ...
"The discovery of bradykinin has led to a new understanding of many physiological and pathological phenomena including ... Moreover, endothelial cells have been described as a potential source for this B1 receptor-CXCL5 pathway.[11] ... Physiological role (function)[edit]. Effects[edit]. Bradykinin is a potent endothelium-dependent vasodilator, leading to a drop ... Wang G, Sun J, Liu G, Fu Y, Zhang X (December 2017). "Bradykinin Promotes Cell Proliferation, Migration, Invasion, and Tumor ...
This change in the atmosphere increased their effectiveness as nurseries of evolution.[57] While eukaryotes, cells with complex ... Gordon, M.S; Graham, J.B. & Wang, T. (September-October 2004). "Revisiting the Vertebrate Invasion of the Land". Physiological ... However, when confronted with totally unexpected phenomena, such as the first evidence for invisible radiation, experimental ... Multicellular life is composed only of eukaryotic cells, and the earliest evidence for it is the Francevillian Group Fossils ...
"Cell Stem Cell. 10 (5): 515-9. doi:10.1016/j.stem.2012.04.002. PMC 3561899. PMID 22560075.. ... See also: Insulin § Physiological effects. Lowering of the concentration of insulin and substances related to insulin, such as ... Caloric restriction lowers the core body temperature, a phenomenon believed to be an adaptive response to reduce energy ... "Aging Cell. 9 (2): 236-42. doi:10.1111/j.1474-9726.2010.00553.x. PMC 3569090. PMID 20096034.. ...
... originating from the same embryonic cells that produce the limbs, whereas mammalian penises arise from the embryonic cells that ... Consequently, females can store sperm internally[13] for as long as five years, or possibly longer.[14] This phenomenon is ... It is thought that the physiological differences between species prevent hybridization. The genital lock-and-key mechanism can ... Squamate hemipenes also develop from a different cell origin, ... known as cryptic female choice, as the physiological mechanisms ...
... the inner hair cells of the organ of Corti. The transfer function of this complex mechanical system under physiological ... A measurable acoustic phenomenon that originates in the inner ear would, at least in theory, allow for more precise assessment ... Ragauskas A, Daubaris G, Ragaisis V, Petkus V (October 2003). "Implementation of non-invasive brain physiological monitoring ... and perilymph caused by contractions of the outer hair cells of the inner ear in response to a loud sound, seems to offer such ...
Costa S, Shaw P (March 2007). "'Open minded' cells: how cells can change fate" (PDF). Trends Cell Biol. 17 (3): 101-6. PMID ... Such effects on cellular and physiological phenotypic traits may result from external or environmental factors, or be part of ... Historically, some phenomena not necessarily heritable have also been described as epigenetic. For example, the term epigenetic ... Adult stem cells like bone marrow stem cells have also shown a potential to differentiate into cardiac competent cells when ...
Autoimmune destruction of the adrenal cortex is caused by an immune reaction against the enzyme 21-hydroxylase (a phenomenon ... Eosinophilia and lymphocytosis (increased number of eosinophils or lymphocytes, two types of white blood cells) ... or prednisone tablets in a dosing regimen that mimics the physiological concentrations of cortisol. Alternatively, one-quarter ... seeding of cancer cells from elsewhere in the body, especially lung), hemorrhage (e.g., in Waterhouse-Friderichsen syndrome or ...
The threadlike muscle fibers are the individual muscle cells (myocytes), and each cell is encased within its own endomysium of ... A display of "strength" (e.g. lifting a weight) is a result of three factors that overlap: physiological strength (muscle size ... This phenomenon is called cross education.[citation needed]. Atrophy. Main article: Muscle atrophy ... In one line of thought scientists have believed that muscle cells evolved once and thus all animals with muscles cells have a ...
By contrast, in vivo experiments can provide information about the physiological role of a protein in the context of a cell or ... Lectins typically play a role in biological recognition phenomena involving cells and proteins.[39] Receptors and hormones are ... Other proteins are important in cell signaling, immune responses, cell adhesion, and the cell cycle. In animals, proteins are ... Abundance in cells. It has been estimated that average-sized bacteria contain about 2 million proteins per cell (e.g. E. coli ...
"Phenomena: Not Exactly Rocket Science How Chickens Lost Their Penises (And Ducks Kept Theirs)". Phenomena.nationalgeographic. ... Birds have specialised light-sensing cells deep in their brains[permanent dead link] that respond to light without input from ... Water is needed by many birds although their mode of excretion and lack of sweat glands reduces the physiological demands.[128] ... Birds are tetrachromatic, possessing ultraviolet (UV) sensitive cone cells in the eye as well as green, red and blue ones.[88] ...
... is formed during physiological respiration when oxygen binds to the heme component of the protein hemoglobin in red blood cells ... This phenomenon, where molecule Y affects the binding of molecule X to a transport molecule Z, is called a heterotropic ... Presence in nonerythroid cells[edit]. Some nonerythroid cells (i.e., cells other than the red blood cell line) contain ... mesangial cells in the kidney, endometrial cells, cervical cells and vaginal epithelial cells.[11] In these tissues, ...
The rebound phenomenon, also known as the loss of the check reflex, is also sometimes seen in patients with cerebellar ataxia, ... The term "ataxia" is sometimes used in a broader sense to indicate lack of coordination in some physiological process. Examples ... Jarius S, Wildemann B (September 2015). "'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune ... Jarius S, Wildemann B (September 2015). "'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune ...
Cell Physiological Phenomena 33 works Search for books with subject Cell Physiological Phenomena. Search. ... Are you sure you want to remove Cell Physiological Phenomena from your list? ... Accessible book, Protected DAISY, Physiology, Cells, Cytology, Methods, Cell physiology, Biological Transport, Biomechanics, ...
A Physiological Phenomenon. The Nature of the Existence of Matter. By E. R. Knowles ...
... by molecular and signaling networks ultimately requires the coordinated regulation of mechanical properties in individual cells ... Plant Cells / physiology * Plant Development* * Plant Growth Regulators / physiology* * Plant Physiological Phenomena ... by molecular and signaling networks ultimately requires the coordinated regulation of mechanical properties in individual cells ...
Plant Physiological Phenomena* * Plants / genetics * Proteins / metabolism * RNA Splicing * RNA, Messenger Substances * ... Functional transformation of microbodies in higher plant cells Cell Struct Funct. 1996 Oct;21(5):387-93. doi: 10.1247/csf. ... 1 Department of Cell Biology, National Institute for Basic Biology, Okazaki, Japan. ...
Cell Physiological Phenomena * Humans * Mitochondria / metabolism* * Reactive Oxygen Species / metabolism* * Signal ... maintenance of stem cell populations, cellular survival, and oncogenic transformation. ...
Bio-inspired engineering of cell- and virus-like nanoparticles for drug delivery. Biomaterials. 2017 Dec; 147:155-168. ... "Virus Physiological Phenomena" by people in Harvard Catalyst Profiles by year, and whether "Virus Physiological Phenomena" was ... "Virus Physiological Phenomena" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Virus Physiological Phenomena" by people in Profiles. ...
Cell Differentiation • Cell Movement • Chronobiology Phenomena • Directed Molecular Evolution • Evolution, Molecular • Face • ... Adaptation, Physiological • Aging • Anatomy, Comparative • Animal Diseases • Animals • Animals, Newborn • Artiodactyla • ...
Proctolin Source Cells --. A.5.2. Myotropic Factors --. A.6. Morphological and Physiological Color Change --. A.6.1. Insect and ... Physiological Color Change --. 6.3. Conclusions --. 7 Behavior and Rhythmic Phenomena --. 7.1. Flight --. 7.2. Circadian ... Proctolin Source Cells -- A.5.2. Myotropic Factors -- A.6. Morphological and Physiological Color Change -- A.6.1. Insect and ... Physiological Color Change -- 6.3. Conclusions -- 7 Behavior and Rhythmic Phenomena -- 7.1. Flight -- 7.2. Circadian Rhythms ...
Maternal Nutritional Physiological Phenomena / genetics*. Ovulation. Pregnancy. Pregnancy Outcome. Pregnancy Rate. ... Next Document: Porcine nuclear transfer using somatic donor cells altered to express male germ cell function.. ... Adaptation, Physiological / genetics. Animals. Cyclooxygenase 2 / genetics, metabolism. Dinoprost / metabolism. Dinoprostone / ... Proliferating Cell Nuclear Antigen / genetics, metabolism. RNA, Messenger / metabolism. Receptor, Interferon alpha-beta / ...
Circulatory And Respiratory Physiological Phenomena. Functional processes and properties characteristic of the BLOOD; ... More From BioPortfolio on "Project A3sc - An Atlas of Airways at a Single Cell Level". *Related Companies*Related Events* ... The purpose of this research study is to collect cells and liquid from the air passages of healthy adults, both smokers and non ... Project A3sc - An Atlas of Airways at a Single Cell Level. 2018-02-22 19:05:23 , BioPortfolio ...
Cell Physiological Processes [G04.299]. *Cell Movement [G04.299.283]. *Physiological Phenomena [G07]. *Physiological Processes ... The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM ... "Cell Movement" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Cell Movement" by people in Harvard Catalyst Profiles by year ...
... and the role of cell production, cell function, and cell elimination in physiological growth control. ... extrachromosomal phenomena; non-genotoxic carcinogens; immortalization and transformation of cells; ... 1. General Concepts 2. Cell Transformation 3. From Factor Dependence to Factor Independence ...
The importance of the observed phenomenon is twofold. On one hand, melatonin has a proposed physiological role in the aging ... Exposure of cells to Aβ(25-35) induced cell death in over two-thirds of the cells by 24 hr (as assessed by the above-mentioned ... Exposure of cells to Aβ(25-35) resulted in marked cell damage characterized by diffuse membrane blebbing (Fig. 3 B), cell ... Control cells exhibited an average intracellular Ca2+/fluo-3 fluorescence of 0.3 ± 0.1 RFI units (n = 20 cells), whereas cells ...
There is yet no consensus among biologists on the prevalence and physiological and therapeutic relevance of stem cell ... This phenomenon is referred to as stem cell transdifferentiation or plasticity. It can be induced by modifying the growth ... Stem cell division and differentiation. A - stem cells; B - progenitor cell; C - differentiated cell; 1 - symmetric stem cell ... Cell Division[edit]. To ensure self-renewal, stem cells undergo two types of cell division (see Stem cell division and ...
Ultrastructural and analytical evidence for an unusual cellular phenomenon. Cell Tissue Res 173:417-421PubMedCrossRefGoogle ... Koštál V (2006) Eco-physiological phases of insect diapause. J Insect Physiol 52:113-127PubMedCrossRefGoogle Scholar ... Physiological and biochemical responses to cold and drought in the rock-dwelling pulmonate snail, Chondrina avenacea ... Chown SL, Nicolson SW (2004) Insect physiological ecology. Oxford, New YorkCrossRefGoogle Scholar ...
Cardiovascular Diseases; Cell Membrane Permeability; Circulatory and Respiratory Physiological Phenomena; Neoplasms; Chemicals ... Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Lung Neoplasms; Small Cell Lung Carcinoma ... Carcinoma, Non-Small-Cell Lung; Immunotherapy; Lung; Medical Oncology; Thoracic Neoplasms; Clinical Trial, Phase I; Clinical ... Biochemistry; Biology; Chemistry; Cell Biology; Neoplasms; Pharmacology; Drugs, Investigational; Proteasome Endopeptidase ...
Cardiovascular Diseases; Cell Membrane Permeability; Circulatory and Respiratory Physiological Phenomena; Neoplasms; Chemicals ... We discovered that Nogo-B promotes the adhesion of endothelial cells and smooth muscle cells and is a potent chemoattractant ... Siragusa M, Sessa WC: Telmisartan exerts pleiotropic effects in endothelial cells and promotes endothelial cell quiescence and ... 3, miRNA regulation of endothelial cell and smooth muscle cell differentiation;. 4. Proteomic analysis of protein ...
Our results hint at possible existence of robust mechanism maintaining stable physiological viscosity of the cytoplasm, despite ... In this paper we address this topic by constant observation of nanoviscosity of HeLa cells cytoplasm during S, G2 and G1 phases ... Nanoviscosity is an outcome of variable chemical and structural factors, which can temporarily change with cell-cycle ... Thus, the question arises, whether rates of biochemical reactions depend on the point of cell cycle. ...
the molecular mechanisms controlling eukaryotic cell biology during physiological and pathological processes. Ongoing projects ... goal is to provide the conceptual framework necessary to interpret biological complexity in relevant phenomena such as cell ... physio-patological cell-to-cell communication; • expression and function of non protein coding genes: role of small and long ... the mechanisms of cross-presentation of pathogen-associated antigens to CD8 T cells by dendritic cells; • the mechanisms ...
Brief overview of research on red blood cell morphology in bloodstains and its application to archaeology, palaeoanthropology, ... Physiological shapes. DISCOCYTES, ECHINOCYTES, SPHEROCYTES, etc.. Biconcave cells, burr cells, spherical cells, etc.. ... But two time-independent RBC shapes are due specifically to blood drying phenomena. So they can be considered as genuine RBC ... burr or berry cells), dacryocytes (tear drop cells), schizocytes (helmet cells), keratocytes (horn cells), drepanocytes (sickle ...
... a strange phenomenon was observed. Binding interactions between the white blood cells and the vessel walls were observed to ... This topic was finally able to be studied thoroughly under physiological shear stress conditions using a typical flow chamber.[ ... "Microfluidic devices for modeling cell-cell and particle-cell interactions in the microvasculature". Microvascular Research. 82 ... For a catch-bond, the force on the cell pulls the adhesive tip of a fimbria to close tighter on its target cell. As the ...
Menzel, R. and Backhaus, W. G. K. (1989). Color vision in honey bees: phenomena and physiological mechanisms. In Facets of ... ectopic expression and physiological characterization of the R8 photoreceptor cell-specific Rh5 and Rh6 rhodopsins. J. Neurosci ... Franceschini, N., Kirschfeld, K. and Minke, B. (1981). Fluorescence of photoreceptor cells observed in vivo.Science 213,1264 - ... In this way, one can largely remove light scattered by pigments in the pigment cells and suppress the reflections from lens ...
... are small non-coding RNAs that regulate various biological phenomena, such as development and homeostasis. The dysregulation of ... cancer cell-cell communication circulating miRNAs exosomes human body fluids miRNAs physiological phenomena purification ... The first section involves the study of secretory miRNAs in cell-cell communication, and the second, the study of circulating ... Methods of Analysis of Dendritic Cell-Derived Exosome-Shuttle MicroRNA and Its Horizontal Propagation Between Dendritic Cells ...
These cells provide progenitor cells for the surrounding meristems. We would like to know if the lines of communication are ... Many human disorders are presumably caused by this phenomenon, including ischemia, Huntingtons disease, and epilepsy. Using a ... Neural crest cells are a stem cell population that migrates from the neural tube early in development. They migrate extensively ... Our goal is to produce genetically engineered plant cells and use these cells as factories for production of biofuel and ...
Subjects: Cell Physiological Phenomena Cytology Online book * Activation of immediate early genes by drugs of abuse ...
This includes the widespread phenomenon of organic acid excretion. One strong hurdle to fully exploit the metabolic capacity of ... In contrast, we do not understand well even basic physiological behavior in these organisms. This includes the widespread ... In contrast, we do not understand well even basic physiological behavior in these organisms. ... phenomenon of organic acid excretion. One strong hurdle to fully exploit the metabolic capacity of these organisms is the ...
Importantly, under physiological conditions, the cells actively maintain an intermediate size (Fig. 5H). After animals death, ... We hypothesize that T. adhaerens tissue integrity is maintained by activation of the two counteracting cellular phenomena- ... Cell cortex, cell junctions, and associated cell membrane create a stress-bearing continuum, whereas discrete cells are ... softening of the cells can prevent detachment of cell-cell junctions, but expose the tissue to rupture by extreme cell strain. ...
Bacterial Physiological Phenomena (drug effects) *Bandages. *Cell Survival (drug effects) *Cells, Cultured ... ions and thereby reducing the cytotoxic effect of mafenide on fibroblast cells. ...
... and Apostain were performed to detect apoptotic cells on sections of ovaries and oviducts. In ovaries, both phenomena affect ... Immunohistochemical methods were used to visualize cell proliferation with the detection of Ki67 antibody, a protein present in ... proliferative cells; terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) ... governed by equilibrium of proliferation and apoptotic phenomena. ...
Cell Host Microbe. 2011 Feb 17; 9(2):147-57.. View in: PubMed ... "Bacterial Physiological Phenomena" is a descriptor in the ... "Bacterial Physiological Phenomena" by people in this website by year, and whether "Bacterial Physiological Phenomena" was a ... Below are the most recent publications written about "Bacterial Physiological Phenomena" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Bacterial Physiological Phenomena". ...
  • Discuss the effects of cancer, as they relate to the underlying cell physiology. (meducation.net)
  • During the last decade, knowledge of α-cell physiology has greatly improved, especially concerning molecular and cellular mechanisms. (meducation.net)
  • In this review, we have addressed recent findings on α-cell physiology and the regulation of ion channels, electrical activity, calcium signals and glucagon release. (meducation.net)
  • A better understanding of the α-cell physiology is necessary for an integral comprehension of the regulation of glucose homeostasis and the development of diabetes. (meducation.net)
  • In 1997, he was recruited to The Ohio State University to help create the Heart and Lung Research Institute where he was deputy director of the institute as well as professor of internal medicine, physiology and cell biology. (hopkinsmedicine.org)
  • From the initial attempts at purposeful genetic modification of a cell for the production of valuable compounds, we have now moved on to changing microbes genetically or metabolically.The arsenal of experimental and theoretical tools available for Metabolic and Cellular Engineering has expanded enormously, driven by the re-emergence of Physiology as Systems Biology. (whsmith.co.uk)
  • Discovery of cytoglobin and its roles in physiology and pathology of hepatic stellate cells. (thefreelibrary.com)
  • Stem cell division and differentiation. (wikipedia.org)
  • To ensure self-renewal, stem cells undergo two types of cell division (see Stem cell division and differentiation diagram). (wikipedia.org)
  • Cellular and organ development is under the equilibrium of three phenomena: proliferation, differentiation and degeneration. (mdpi.com)
  • Andrea Rocco investigates noise propagation across molecular networks, and stochastic dynamics in cell differentiation. (surrey.ac.uk)
  • These cells identified as Gr-1 + CD11b + cells are comprised of precursors of macrophages, granulocytes, DC, and myeloid cells at earlier stages of differentiation (for review, see Refs. (jimmunol.org)
  • NSPCs in the SGZ, which differentiate into granular cells, are anchored within the granular layer of the DG, and following differentiation, establish synaptic connections with neighboring neurons, and maintain the function of the hippocampus. (intechopen.com)
  • The introductory chapters discuss the discovered RNA phages with particular emphasis on the use of specific and transformed cells to study cell formation and differentiation. (worldcat.org)
  • Biological phenomena, such as cellular differentiation and phagocytosis, are fundamental processes that enable cells to fulfill important physiological roles in multicellular organisms. (sciencemag.org)
  • We discuss studies that used these systems in a broad range of cellular and molecular phenomena, including the time-dependent modulation of protein activity in cellular proliferation and differentiation, the reconstitution of phagocytosis, the reconstitution of chemotaxis, and the regulation of actin reorganization. (sciencemag.org)
  • The secretion of glucagon by pancreatic α-cells plays a critical role in the regulation of glycaemia. (meducation.net)
  • However, the control of growth and morphogenesis by molecular and signaling networks ultimately requires the coordinated regulation of mechanical properties in individual cells. (nih.gov)
  • Regulation of vascular reactivity in Scleroderma: new insights into Raynaud's phenomenon. (hopkinsmedicine.org)
  • Can we understand the gene regulation phenomena in a cellular/physiological context? (searlescholars.net)
  • The term apoptosis is proposed for a hitherto little recognized mechanism of controlled cell deletion, which appears to play a complementary but opposite role to mitosis in the regulation of animal cell populations. (nih.gov)
  • In this review, we consider and discuss the physiological and pathological roles of CYGB in the regulation of HSC activities in relation to their intracellular [O.sub.2] homeostasis. (thefreelibrary.com)
  • The cortical MT array has been linked to the regulation of cellulose microfibril deposition and, hence, a role in cell expansion, while the pre-prophase band and the phragmoplast have important roles in the positioning and synthesis of the new cell plate in dividing cells. (mcponline.org)
  • Production of ROS at mitochondria thus integrates cellular energy state, metabolite concentrations, and other upstream signaling events and has important implications in cellular stress signaling, maintenance of stem cell populations, cellular survival, and oncogenic transformation. (nih.gov)
  • We have implemented an unbiased cell morphology-based screen to identify small-molecule modulators of cellular processes using the Cytometrix (TM) automated imaging and analysis system. (biomedsearch.com)
  • The cell cycle is a universal process during which, through a series of cellular events, single cell gives rise to two daughter individuals. (nature.com)
  • IL-1, TNFα and C5a [1] cause the endothelial cells of blood vessels near the site of infection to express cellular adhesion molecules , including selectins . (wikipedia.org)
  • Here we report the discovery of the fastest epithelial cellular contractions known in any metazoan, to be found in T. adhaerens dorsal epithelium (50% shrinkage of apical cell area within one second, at least an order of magnitude faster than other known examples). (pnas.org)
  • The Molecular, Cellular & Physiological Biology Area is proud of its many lab classes and the connection to biomedical research. (csun.edu)
  • My laboratory is studying the cellular mechanisms responsible for coordinating the migration of these cells. (csun.edu)
  • To investigate vascular function, Dr. Flavahan's methods range from biochemical or molecular analyses of cellular mediators and cell signaling mechanisms in cultured vascular cells to physiological assessment and fluorescent microscopic imaging of signaling systems in isolated blood vessels. (hopkinsmedicine.org)
  • This communication is mediated by direct cellular contacts (e.g., synapse formation between neurons or between immune cells) and by soluble mediators (neurotransmitters or cytokines). (nature.com)
  • 1 At the cellular level, the tumor is comprised not only of cancer cells but also a diverse population that includes stromal cells, endothelial cells, components of immune cells, and cancer stem cells (CSCs). (sigmaaldrich.com)
  • This is consistent with a role in neurodegeneration, in which microglial activation could be a consequence of a degenerative process, as these phagocytic cells participate in cleaning up cellular debris. (hindawi.com)
  • He uses baker's yeast, nematodes, and mammalian cells to investigate the conservation of gene regulatory circuits, its connection to other levels of cellular control (metabolism), and the implications in health and disease. (surrey.ac.uk)
  • Although I doubt that there is very much NADH or NAD+ in normal extra cellular fluid there has to be an NADH docking site on the outer redox enzyme as one of the hallmarks of cell surface oxygen consumption is that it can be halted completely by flooding the cell culture medium with NADH. (blogspot.com)
  • This Review will focus on a subset of synthetic biology tools known as bottom-up techniques, which use technologies such as optogenetics and chemically induced dimerization to reconstitute cellular behavior in cells. (sciencemag.org)
  • It provides a framework for cell division and the trafficking of organelles and macromolecules, and also serves to regulate important cellular processes such as signaling, translation, and metabolism. (mcponline.org)
  • A novel superresolution nanoscope allows 3D imaging of an entire mammalian cell and its cellular constituents at a resolution that is 20 to 50 times higher than conventional microscopy , with imaging depth improved approximately tenfold over state-of-the-art iPALM and 4Pi-SMSN implementations. (photonics.com)
  • One goal is to further push the envelope in the direction of live-cell and tissue imaging, two major roadblocks of modern superresolution techniques, and therefore allow visualization of cellular functions live in their physiological conditions at the nanoscale," said Fang Huang, professor of biomedical engineering at Purdue. (photonics.com)
  • It is believed that the molecular distinction between symmetric and asymmetric divisions lies in differential segregation of cell membrane proteins (such as receptors ) and their associated proteins between the daughter cells. (wikipedia.org)
  • We have isolated caveolae from endothelial cells in culture and have identified several new proteins. (yale.edu)
  • Transmigration of the leukocyte occurs as PECAM proteins, found on the leukocyte and endothelial cell surfaces, interact and effectively pull the cell through the endothelium. (wikipedia.org)
  • By delivering suppressive cargos consisting of proteins similar to those in parent tumor cells to immune cells, TEX directly or indirectly influence the development, maturation, and antitumor activities of immune cells. (jci.org)
  • The ascospores showed differences in the inner cell wall region at the lateral ridge of the spore and also qualitative differences in extractable proteins but did not differ in fatty acid or lipid content. (asm.org)
  • The most extensively investigated invasion mechanism requires the Type III Secretion System-1 (T3SS-1) encoded by the Salmonella pathogenicity island 1 (SPI-1), a needle-like structure which directly injects bacterial effector proteins into the host cell cytoplasm to manipulate cell signaling pathways leading to actin cytoskeletal rearrangement and bacterial internalization ( Ly and Casanova, 2007 ). (frontiersin.org)
  • We show that the level of expression and the spatial distribution of hyaluronan at the cell-substrate interface, together with the surface density of extracellular matrix proteins, regulate cell adhesion and migration. (aps.org)
  • Movement, motility, and conformational dynamics of proteins are the basic phenomena of life underlying various physiological and pathological processes of the cell. (hindawi.com)
  • This study, for the first time, has demonstrated that tumor-bearing host-derived ImC, but not their progeny or Gr-1 + cells from control mice, are not only able to migrate into the tumor site and pick up soluble proteins, but also process them and induce Ag-specific tolerance of CD8 + T cells. (jimmunol.org)
  • cells were unambiguously identified by cell specific expression of fluorescent proteins. (jove.com)
  • Interactions between cell-surface proteins help coordinate the function of neighboring cells. (jove.com)
  • It is becoming increasingly clear that interactions between transmembrane proteins on the surfaces of adjacent beta cells are important determinants of beta-cell function. (jove.com)
  • These approaches also alter levels of the intracellular domains of the targeted proteins and may prevent effects due to interactions between proteins within the same cell membrane to be distinguished from the effects of transcellular interactions. (jove.com)
  • It is based on coculture models developed by neurobiologists, who found that exposure of cultured neurons to specific neuronal proteins expressed on HEK293 (or COS) cell layers identified proteins important for driving synapse formation. (jove.com)
  • Miami Winter Symposia, Volume 16: From Gene to Protein: Information Transfer in Normal and Abnormal Cells presents the expression and processing of genetic information at the levels of both proteins and nucleic acids. (worldcat.org)
  • These proteins, often called MT-interacting proteins (MIPs) ( 2 , 4 ), likely bind to MTs as a mechanism to regulate their own activity, to direct their subcellular localization, or as a concentrating mechanism at specific locations within the cell. (mcponline.org)
  • The large surface area provided by the MT network, and the cytoskeleton as a whole, likely serves as a matrix for the binding of hundreds of proteins to an extent that is dependent on cell type and environmental conditions ( 6 ). (mcponline.org)
  • The W-4PiSMSN incorporates deformable mirrors using two objectives, one above and one below the sample, and uses a set of algorithms to pinpoint molecular positions of proteins deep inside cells, resolving features deep below the surface of the sample. (photonics.com)
  • W-4PiSMSN is a versatile and powerful tool that promises a new perspective on how proteins distribute across entire organelles throughout whole cells, an as yet unmet challenge in cell biology. (photonics.com)
  • Bacterial Physiological Phenomena" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Bacterial Physiological Phenomena" by people in this website by year, and whether "Bacterial Physiological Phenomena" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Bacterial Physiological Phenomena" by people in Profiles. (umassmed.edu)
  • Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. (nih.gov)
  • In the second stage these apoptotic bodies are shed from epithelial-lined surfaces or are taken up by other cells, where they undergo a series of changes resembling in vitro autolysis within phagosomes, and are rapidly degraded by lysosomal enzymes derived from the ingesting cells.Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development. (nih.gov)
  • A comprehensive in vitro and in vivo study using pH-responsive poly(ethylene oxide)-PbAE (PEO-PbAE) copolymer system demonstrated higher apoptosis in MDA-MB-231 breast cancer cells and effectively accumulated into the SKOV3 human ovarian cancer xenograft model. (sigmaaldrich.com)
  • Two hallmarks of cancer cells appear to be abnormal electron transport function and free radical leakage from the ETC. The free radical leakage is at levels which cause proliferation rather than apoptosis. (blogspot.com)
  • In addition, triterpenoid saponins inhibited tumor growth and induced the apoptosis of HCC cells by blocking the activation of PD1/PD-L1, ERK1/2, p38 MAPK, JNK, and STAT3 signaling pathways. (dovepress.com)
  • Laboratory experiences integrated with lecture enable students to examine anatomical and physiological phenomena of the human body. (wvstateu.edu)
  • Next, students examine anatomical and physiological features of plants and animals. (southalabama.edu)
  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate various biological phenomena, such as development and homeostasis. (springer.com)
  • Life Science I examines the basic principles of biological phenomena. (southalabama.edu)
  • Topics for the Miami Winter Symposia focus on areas of biochemistry in which recent progress offers new insights into the molecular basis of biological phenomena. (worldcat.org)
  • This volume summarizes the progress in selected areas of biochemistry and the insights into the molecular basis of biological phenomena. (worldcat.org)
  • The advance could reveal biological phenomena never before seen, bringing novel medical insights. (photonics.com)
  • Virus Physiological Phenomena" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Our laboratory is focused on understanding the etiology of vascular dysfunction in these diseases and is focused on several broad aspects of endothelial cell biology and function. (yale.edu)
  • This curriculum will focus on the molecular mechanisms underlying the fundamental processes of the biology of prokaryotic cells and viruses and their interactions with host. (uniroma1.it)
  • This curriculum will focus on the molecular mechanisms underlying the fundamental processes of the biology of Eukaryotic cells. (uniroma1.it)
  • the molecular mechanisms controlling eukaryotic cell biology during physiological and pathological processes. (uniroma1.it)
  • A better understanding of adipose stem cell biology and adipogenesis may lead to novel strategies to uncouple obesity from metabolic disease. (jci.org)
  • Cell migration is a coordinated process that is ubiquitous in biology and plays a significant role in biological processes, such as morphogenesis, cancer metastasis, and tissue repair. (aps.org)
  • Testmetoder Yta Redovisning av Chemosensory Receptorer i heterologa Cells Sandeepa Dey 1 , Senmiao Zhan 2 , Hiroaki Matsunami 1 1 Department of Molecular Genetics and Molecular Biology , Duke University, 2 Department of Chemistry, Duke University Här visar vi ett protokoll för att utföra levande cell färgning som kan användas för att upptäcka luktreceptorer på ytan av HEK293T celler bekvämt. (jove.com)
  • The development of genetically encoded probes that allow quantification of ROS (reactive oxygen species) at a cell-specific and subcellular resolution in living tissues, and in real-time, have facilitated a more sophisticated understanding of the role of ROS in signalling and development [ 1 , 2 ]. (portlandpress.com)
  • Cell Metabolism, 10: 208-218 (2009). (yale.edu)
  • Identifying the pathways that lead to APP phosphorylation in vivo , in normal physiological state, could help understand important aspects of APP transport and metabolism. (jneurosci.org)
  • Using the technique developed here, we quantify the total active traction profiles that aggregates of mammalian cells exert on the boundary of synthetic spherical hydrogel bodies and report the stress profiles within tumor-cell spheroids. (aps.org)
  • He uses yeast and mammalian cells to investigate how dynamics switches timely control the eukaryotic cell division cycle. (surrey.ac.uk)
  • Mammalian auditory hair cells do not regenerate and, therefore, have to maintain their precisely arranged stereocilia throughout the lifespan of the organism. (elifesciences.org)
  • However, it is known that in vitro cell culture conditions can alter the behavior of cells, proving that a particular subpopulation of cells possesses stem cell properties in vivo is challenging, and so considerable debate exists as to whether some proposed stem cell populations in the adult are indeed stem cells. (wikipedia.org)
  • My laboratory investigates the physiological and biochemical effects that neurotransmitters have on the behavior of animals. (csun.edu)
  • In contrast, we do not understand well even basic physiological behavior in these organisms. (frontiersin.org)
  • We explain contact-inhibition of locomotion in a new way, and show how the collective migration behavior varies with cell density. (aps.org)
  • An unbiased cell morphology-based screen for new, biologically active small molecules. (biomedsearch.com)
  • Four human-cancer cell lines and one noncancerous primary cell type were treated with 107 small molecules comprising four different protein kinase-inhibitor scaffolds. (biomedsearch.com)
  • Activated endothelial cells initially express P-selectin molecules, but within two hours after activation E-selectin expression is favoured. (wikipedia.org)
  • What roles do various intracellular molecules have in reducing or exacerbating this phenomenon? (csun.edu)
  • Tumor-derived exosomes (TEX) are harbingers of tumor-induced immune suppression: they carry immunosuppressive molecules and factors known to interfere with immune cell functions. (jci.org)
  • 1990). When copper availability is adequate to allow the synthesis of the full complement of plastocyanin (~ 8 x 10 6 molecules per cell), the Cyc6 gene encoding cytochrome c 6 is transcriptionally silent (Merchant et al. (searlescholars.net)
  • Cancer is a complex disease involving many different cell types, extracellular matrices, immune factors, signaling molecules, and physiological phenomena. (sigmaaldrich.com)
  • M1 macrophages classically are activated by IFN-γ, with or without microbial products, produce large amounts of proinflammatory cytokines, express high levels of MHC molecules, and are implicated in the killing of pathogens and tumor cells ( 3 ). (jimmunol.org)
  • Youngchan Kim applies protein engineering and optical spectroscopy approaches to investigate biological molecules and systems that exploit quantum phenomena under physiological conditions. (surrey.ac.uk)
  • E-Selectin, vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) are adhesion molecules participating in mediating interactions between leukocytes and endothelial cells and have been found to be expressed in atherosclerotic plaques. (ahajournals.org)
  • 1 2 The adhesion molecules E-selectin, VCAM-1, and ICAM-1 support monocyte adhesion to and interaction with endothelial cells and, hence, may play a crucial role in the pathogenesis of atherosclerosis. (ahajournals.org)
  • The finding that the amyloid β protein (Aβ) has neurotoxic properties and that such effects are, in part, mediated by free radicals has provided insights into mechanisms of cell death in AD and an avenue to explore new therapeutic approaches. (jneurosci.org)
  • Developmental cell death: morphological diversity and multiple mechanisms. (nih.gov)
  • The multiplicity of destructive mechanisms needs to be born in mind in studies of other aspects of cell death such as the signals which trigger it, since different signals probably trigger different types of cell death. (nih.gov)
  • To illuminate mechanisms of cell migration within a unified framework, we developed a versatile, computational model for cell migration on 2D substrates. (aps.org)
  • Moreover, immune cells can synthesize and release neurotransmitters themselves, thus using neurotransmitter-mediated pathways via autocrine and paracrine mechanisms. (nature.com)
  • T cell tolerance is one of the major mechanisms of tumor escape and one of the major factors limiting the success of cancer vaccines. (jimmunol.org)
  • The chapters provide a timely update on recent advances in this field and comprehensively summarize the current state of knowledge concerning the molecular and physiological mechanisms behind circadian and ultradian oscillations in plants, their physiological implications for growth and development and adaptive responses to a dynamic environment. (nhbs.com)
  • Models of human pattern vision mechanisms are examined in light of new results in psychophysics and single-cell recording. (spie.org)
  • Genetic methods to enrich for mother cells in populations by inducing death of daughter cells have been developed, but population sizes are still limited by the frequency with which random mutations that compromise the selection systems occur. (jove.com)
  • It is also fuelling the resurgence of eugenics and genetic discrimination, and making even the most unethical uses seem compelling, such as the creation of human embryos to supply cells and tissues for transplant in so-called 'therapeutic' human cloning [4]. (i-sis.org.uk)
  • Both are redox-active cofactors found in quantity in electron transfer pathways, such as respiration and photosynthesis, which, in eukaryotic cells, are localized to the mitochondria and chloroplasts. (searlescholars.net)
  • It bypasses all of the energetic processes in the rest of the TCA so delivers very little to the ETC. The normal function of this pathway appears to be a safety valve for the cell when the mitochondria are presented with far too much acetyl-CoA. (blogspot.com)
  • Properties of the probe were validated in living plant cells and in isolated mitochondria, and the sensitivity of the probe to mitochondrial bioenergetics, superoxide production and pH were established. (portlandpress.com)
  • Exosome secretion by cells seems to be a physiological phenomenon that occurs spontaneously. (jci.org)
  • We further demonstrate that coculture of tumor-associated macrophages and tumor cells induces secretion of factors that are recognized by SR-A on tumor-associated macrophages. (jimmunol.org)
  • cell calcium oscillations and glucagon secretion at low glucose levels. (jove.com)
  • cell [Ca(2+)](i) and secretion at low glucose levels. (jove.com)
  • Triterpenoid saponins induced anti-tumor immune response by decreasing the number of Treg cells, increasing that of B cells, natural killer cells, and CD3 + /CD28 + T cells, and reducing the secretion of inflammatory factors including nuclear factor-κB, cyclooxygenase-2, and microsomal prostaglandin E synthase-1. (dovepress.com)
  • 10 Specific binding sites for angiotensin II on endothelial cells have been described, 11 and angiotensin II appears to have a modulating effect on several endothelial cell functions, such as prostacyclin, endothelin secretion, 12 13 and endothelial cell growth. (ahajournals.org)
  • Interpretation of bioelectric phenomena. (vutbr.cz)
  • The subject ‚Bioelectric phenomena' acquaints the students with biophysical basis of the genesis of electric signals on different structural levels , with passive electric properties a of living tissue, and with currently available methods of bioelectric measurements. (vutbr.cz)
  • R.Plonsey: Bioelectric Phenomena. (vutbr.cz)
  • Claudio Avignone Rossa uses genome-scale metabolic network models of bacteria and human cell lines to optimize conditions for the production of compounds of medical and industrial interest. (surrey.ac.uk)
  • He is also interested in the study of the metabolic and physiological interactions between species in natural and synthetic microbial ecosystems, and how these evolve and adapt to changes in their environment. (surrey.ac.uk)
  • Viruses can replicate very fast and may affect any metabolic and physiological function of the host cell. (eurekaselect.com)
  • Exosomes, small membrane-bound vesicles, are a class of extracellular vesicles (EVs) made and released by most, if not all, cells. (jci.org)
  • Contractile cells such as fibroblasts exert physical forces on the surrounding extracellular matrix ECM and these forces can lead to material remodeling. (aps.org)
  • And 'Extracellular metabolisation of NADH by blood cells correlates with intracellular ATP levels. (blogspot.com)
  • In this model, the beta-cell cytoplasm is untouched while extracellular protein-protein interactions are manipulated. (jove.com)
  • the interactions of host cell with viral, prokaryotic and eukaryotic pathogens. (uniroma1.it)
  • To establish an infection, Salmonella has to interact with eukaryotic cells. (frontiersin.org)
  • The cytoskeleton is the single most important structure that contributes to the highly ordered organization of the eukaryotic cell. (mcponline.org)
  • SR-A is restricted to the myeloid lineage and is expressed on most mature tissue macrophages and on bone marrow-derived dendritic cells and splenic dendritic cells but not on their immature precursor monocytes. (jimmunol.org)
  • Neither ImC from control mice nor progeny of tumor-derived ImC, including tumor-derived CD11c + dendritic cells, were able to render T cells nonresponsive. (jimmunol.org)
  • In physiological conditions, APCs consist of primarily dendritic cells (DC) 4 and macrophages. (jimmunol.org)
  • Its morphological features suggest that it is an active, inherently programmed phenomenon, and it has been shown that it can be initiated or inhibited by a variety of environmental stimuli, both physiological and pathological.The structural changes take place in two discrete stages. (nih.gov)
  • Muscle cells use an extensively organized but still poorly understood actin-myosin contractile apparatus to generate force and movement and respond to various physiological stimuli. (hindawi.com)
  • Active response suppression (inhibition) is seen whenever cortical cells are exposed to grating stimuli that are non-optimal, in either the domain of orientation or spatial frequency. (spie.org)
  • Haemotaphonomy or hemotaphonomy (from the Greek haima for blood, taphos for burial, and nomos for law) is the science that deals with the cytomorphology of the blood cells in bloodstains. (angelfire.com)
  • These corpuscles have also been identified in prehistoric immovable items, such as an early Holocene building at ay n Tepesi (Turkey), containing anucleate red blood cells, human immunoglobulin G (IgG) and both human and non-human haemoglobin (Hb) on a stone slab. (angelfire.com)
  • In this histological tissue, three types of cells are present: erythrocytes (red blood cells, RBCs), leukocytes (white blood cells, WBCs) and thrombocytes (platelets, in mammals). (angelfire.com)
  • White blood cells (leukocytes) perform most of their functions in tissues. (wikipedia.org)
  • For example, the carbohydrate ligand for P-selectin, P-selectin glycoprotein ligand-1 (PSGL-1), is expressed by different types of leukocytes (white blood cells). (wikipedia.org)
  • The physiological changes following the reaction of lead upon red blood cells are numerous and show the marked effects of a change in the cell surface. (rupress.org)
  • The effects of lead upon red blood cells are thus manifested by shrinkage, inability to expand, increased brittleness, and loss of the normal consistency which makes their surface sticky. (rupress.org)
  • Bilirubin comes from red blood cells. (slideshare.net)
  • When red blood cells get old, they are destroyed. (slideshare.net)
  • Hemoglobin, the iron-containing chemical in red blood cells that carries oxygen, is released from the destroyed red blood cells after the iron it contains is removed. (slideshare.net)
  • Conjugated bilirubin is distinguished from the bilirubin that is released from the red blood cells and not yet removed from the blood which is termed unconjugated bilirubin.Jaundice occurs when there is 1) too much bilirubin being produced for the liver to remove from the blood. (slideshare.net)
  • Another physiological phenomenon involving cold temperatures, is the effect these temperatures have on hemoglobin in the red blood cells. (bikeforums.net)
  • Studies of this phenomenon using cultured tumor cells showed that these vesicles were produced in abundance and induced a variety of functional alterations in immune cells. (jci.org)
  • Alternatively activated macrophages express the pattern recognition receptor scavenger receptor A (SR-A). We demonstrated previously that coculture of macrophages with tumor cells upregulates macrophage SR-A expression. (jimmunol.org)
  • The majority of chemotherapeutic agents used in clinics are highly toxic to both tumor cells and normal tissues due to the lack of specificity. (dovepress.com)
  • In vitro cytotoxicities against human solid tumor cells were measured in 7 - day MTT assays at Purdue Cancer Center , Cell Culture Laboratory of Purdue University, West Lafayette, Indiana, USA, for the A-549 ( lung carcinoma), MCF - 7 (human breast carcinoma) and HT - 29 (human colon adenocarcinoma). (scielo.cl)
  • Tissue topography steers migrating Drosophila border cells. (harvard.edu)
  • [1] Unlike for embryonic stem cells, the use of human adult stem cells in research and therapy is not considered to be controversial , as they are derived from adult tissue samples rather than human embryos designated for scientific research. (wikipedia.org)
  • Under normal conditions, tissue stem cells divide slowly and infrequently. (wikipedia.org)
  • Selectins are expressed shortly after cytokine activation of endothelial cells by tissue macrophages. (wikipedia.org)
  • We also show that unique cell and tissue architecture indeed minimizes the load on a contracting cell. (pnas.org)
  • Finally, we suggest a physiological role for these contractions: maintaining the integrity of such a minimalistic tissue. (pnas.org)
  • Live imaging reveals emergent contractile patterns that are mostly sporadic single-cell events, but also include propagating contraction waves across the tissue. (pnas.org)
  • We show that cell contraction speed can be explained by current models of nonmuscle actin-myosin bundles without load, while the tissue architecture and unique mechanical properties are softening the tissue, minimizing the load on a contracting cell. (pnas.org)
  • We propose a hypothesis, in which the physiological role of the contraction dynamics is to resist external stresses while avoiding tissue rupture ("active cohesion"), a concept that can be further applied to engineering of active materials. (pnas.org)
  • The molecular and mechanical mechanism of contraction in these nonmuscle cells, as well as their tissue level control ( 5 ⇓ - 7 ), are under intensive investigation ( 5 ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ - 13 ). (pnas.org)
  • Here, we highlight recent human and rodent studies that support the notion that the ability to recruit new fat cells through adipogenesis is a critical determinant of healthy adipose tissue distribution and remodeling in obesity. (jci.org)
  • Furthermore, we discuss recent advances in our understanding of the identity of tissue-resident progenitor populations in WAT made possible through single-cell RNA sequencing analysis. (jci.org)
  • Here we propose a new system for quantitatively evaluating cancer cell invasion in a three-dimensional (3D), in vivo tissue-like environment. (rsc.org)
  • This work is providing evidence on how the tissue-specific and time-dependent expression of cell surface carbohydrates may be controlled. (go.jp)
  • M2 macrophages moderate the inflammatory response, eliminate cell debris, and promote angiogenesis and tissue remodeling ( 3 , 5 ). (jimmunol.org)
  • In 2001, we discovered cytoglobin (CYGB) in hepatic stellate cells (HSC), (1) which are important regulators of tissue repair in the damaged liver. (thefreelibrary.com)
  • Regeneration is a process in which tissue parenchymal cells play a major role in reconstructing the lost part of the tissue, resulting in both structural and functional restoration. (thefreelibrary.com)
  • Repair is a process in which non-parenchymal connective tissue cells largely contribute to reconstructing the damaged tissue, resulting in structural but not functional restoration. (thefreelibrary.com)
  • Physical interpretation of electric phenomena in living tissue constitutes a special area of biophysics. (vutbr.cz)
  • This new appreciation that microglia regulate neuronal function and homeostasis under physiological conditions, in the absence of immune challenge or inflammation, raises the possibility that disruption of such processes may contribute to pathological conditions characterized by neuronal or synaptic dysfunction, rather than frank neurodegeneration. (hindawi.com)
  • Pancreatic beta cells are clustered together within pancreatic islets and act in a coordinated fashion to maintain glucose homeostasis. (jove.com)
  • 8) The discovery of CYGB led us to study its biological and pathophysiological importance in the histological homeostasis of the liver and to rethink the biological features of HSCs as a cell type that harbors [O.sub.2]-bearing globin, especially in relation to their activation upon hepatic insult. (thefreelibrary.com)
  • This consideration appeared to be challengeable because, unlike Mb-expressing cells, which are highly contractile (e.g., cardiac and skeletal muscle cells), the hitherto-known functions of HSCs and their activation were not fully discussed from the viewpoint of the intracellular [O.sub.2] homeostasis of HSCs. (thefreelibrary.com)
  • 1. What are the changes that occur in the cells that occur during tumour progression? (brainscape.com)
  • 2. What are the different types of tumour cell migration? (brainscape.com)
  • 3. What physiological phenomena does tumour migration mimic? (brainscape.com)
  • 6. How are tumour cells different in this aspect? (brainscape.com)
  • Nanoviscosity of the cytoplasm is a key factor affecting diffusion of biomolecules and - as a consequence - rates of biochemical reactions in a cell. (nature.com)
  • Thus, the question arises, whether rates of biochemical reactions depend on the point of cell cycle. (nature.com)
  • Written by a diverse group of leading researchers, Rhythms in Plants will spark the interest of readers from many branches of science: from physicists and chemists wishing to learn about the multi-faceted rhythms in plants, to biologists and ecologists involved in the state-of-the-art modelling of complex rhythmic phenomena. (nhbs.com)
  • and just as little, we may expect, will a knowledge of the origin of the existing and extinct species of plants and animals, be the result of physiological and geological investigation. (todayinsci.com)
  • The first section involves the study of secretory miRNAs in cell-cell communication, and the second, the study of circulating miRNAs in body fluids. (springer.com)
  • Given the parallels between the secretory machinery of neuronal synapses and of beta cells, we reasoned that beta-cell functional maturation might be driven by similar transcellular interactions. (jove.com)
  • A good physiological experiment like a good physical one requires that it should present anywhere, at any time, under identical conditions, the same certain and unequivocal phenomena that can always be confirmed. (rice.edu)
  • Cancer cell proliferation is guided through the micropassage because of the physical restriction imposed by the surrounding solid shell regions. (rsc.org)
  • As a result, nanoviscosity affects all diffusion-based interactions in living cell, including biosynthesis, signalling pathways or even active transport 5 . (nature.com)
  • Conversely the structure of the ECM can determine the form of cell motility and cell-cell interactions. (aps.org)
  • We then argue that these deformations allow cells to affect each other with novel long-range (in time) interactions and that these may be responsible for patterns observed both in vitro and in tumor samples. (aps.org)
  • Here we present the development of a force measurement method that uses cell-sized, compressible and elastic hydrogel microspheres (with diameters of 5-50 µm) as force sensors, thereby providing a solid cell-gel interface to promote natural cell-like interactions, and allowing measurements of nominal values of the cell-exerted forces, due to their inherent compressibility. (aps.org)
  • Complex interactions between the cell types in this microenvironment regulate tumor growth, progression, metastasis, and angiogenesis ( 1 ). (jimmunol.org)
  • Elucidation of the roles of particular transcellular interactions by knockdown, knockout or overexpression studies in cultured beta cells or in vivo necessitates direct perturbation of mRNA and protein expression, potentially affecting beta-cell health and/or function in ways that could confound analyses of the effects of specific interactions. (jove.com)
  • Here a method for determining the effect of specific transcellular interactions on the insulin secreting capacity and responsiveness of beta cells is presented. (jove.com)
  • The work in my laboratory focuses on the establishment of specific cell fates using genomics to decipher interactions between chromatin and developmental signaling cascades, between genomes and rapidly evolving cell types, and between genomic copy number variation and gene expression. (stanford.edu)
  • A fraction of full-length APP reaches the plasma membrane and re-enters the cell via endocytosis. (jneurosci.org)
  • As translocation across the plasma membrane is a limiting step for delivery of macromolecules, these polypeptides were utilized in a pancreatic xenograft model to study the plasma clearance, biodistribution, tumor accumulation, and tumor reduction capabilities of the polypeptide with and without a cell-penetrating peptide. (dovepress.com)
  • Each of the electrons is transported via a plasma membrane ubiquinone:semi ubiquinone cycle which then donates them to the redox enzyme on the external cell surface. (blogspot.com)
  • Initially we showed that 7hidroxycholesterol, in physiological concentrations, was incorporated to caveolae more prominently than to other plasma membrane domains. (usp.br)
  • In this study we demonstrate that melatonin, a pineal hormone with recently established antioxidant properties, is remarkably effective in preventing death of cultured neuroblastoma cells as well as oxidative damage and intracellular Ca 2+ increases induced by a cytotoxic fragment of Aβ. (jneurosci.org)
  • The effects of melatonin were extremely reproducible and corroborated by multiple quantitative methods, including cell viability studies by confocal laser microscopy, electron microscopy, and measurements of intracellular calcium levels. (jneurosci.org)
  • Nanoviscosity is an outcome of variable chemical and structural factors, which can temporarily change with cell-cycle associated changes of intracellular architecture. (nature.com)
  • In mammals, long-term energy storage is achieved through production of intracellular triglycerides, stored within specialized cells called white adipocytes. (jci.org)
  • By fusing the kinase with Renilla luciferase and the DARPin to GFP, an energy transfer from luciferase to GFP can be observed in COS-7 cells upon intracellular complex formation. (pnas.org)
  • Adult stem cells are undifferentiated cells , found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate damaged tissues . (wikipedia.org)
  • The cell cycle allows growth and proliferation of cells, development of tissues and whole organisms. (nature.com)
  • According to that conjecture, early animal tissues, lacking rigid unifying cell walls, used contractions to counteract ciliary power and achieve coordinated motility ( 19 ⇓ - 21 ). (pnas.org)
  • Typhlonectes compressicauda females, as studied in previous works, undergo a biennial sexual Cell proliferation is observed during organogenesis, growth, and reparation after injury or cyclical regression of tissues. (mdpi.com)
  • It is implicated in both physiological involution and atrophy of various tissues and organs. (nih.gov)
  • These ImC accumulate in large numbers in spleens, lymph nodes, and tumor tissues of tumor-bearing mice and are comprised of precursors of myeloid cells. (jimmunol.org)
  • Conclusion: The present review is aimed at providing an update on research and development efforts being made to create effective antiviral chemotherapeutic agents and approaches to their delivery to appropriate targeted cells or tissues. (eurekaselect.com)
  • ImC are able to take up soluble protein in vivo, process it, and present antigenic epitopes on their surface and induce Ag-specific T cell anergy. (jimmunol.org)
  • However, whether ImC are able to take up Ags in vivo, process them, and induce lasting Ag-specific T cell tolerance is unknown. (jimmunol.org)
  • However, many compounds identified in screens using cell culture models are often found to be toxic or pharmacologically inactive in vivo 1-2 . (jove.com)
  • Measuring superoxide dynamics in living intact cells, i.e. in vivo , is of particular interest as in most systems superoxide is the precursor for most other ROS and RNS (reactive nitrogen species) such as hydrogen peroxide, the hydroxyl radical or peroxynitrite. (portlandpress.com)
  • Cell migration and invasion are of significant importance in physiological phenomena, including wound healing and cancer metastasis. (rsc.org)
  • Cell migration is omnipresent in a diverse set of biological processes, including wound healing, embryogenesis or cancer metastasis. (aps.org)
  • Also known as somatic stem cells (from Greek Σωματικóς, meaning of the body ), they can be found in juvenile as well as adult animals and humans, unlike embryonic stem cells . (wikipedia.org)
  • [2] These properties can be illustrated with relative ease in vitro , using methods such as clonogenic assays , where the progeny of a single cell is characterized. (wikipedia.org)
  • It can be induced by modifying the growth medium when stem cells are cultured in vitro or transplanting them to an organ of the body different from the one they were originally isolated from. (wikipedia.org)
  • Finally, treatment of tumor-bearing mice with 4F, a small peptide SR-A ligand able to compete with physiological SR-A ligands in vitro, recapitulates the inhibition of tumor progression and metastasis observed in SR-A −/− mice. (jimmunol.org)
  • showed significant biotoxicity effects using the brine shrimp test (BST) and inhibitory activity against cells derived from lung carcinoma (A - 549) , breast carcinoma ( MCF - 7) and colon adenocarcinoma ( HT -29 ) carried in vitro . (scielo.cl)
  • These cells can suppress T cells in vitro. (jimmunol.org)
  • The interrogation of beta cell gene expression and function in vitro has squarely shifted over the years from the study of rodent tumorigenic cell lines to the study of isolated rodent islets. (jove.com)
  • Physiological processes and properties of BACTERIA. (umassmed.edu)
  • This includes the widespread phenomenon of organic acid excretion. (frontiersin.org)
  • Physiological cell death is a widespread phenomenon in the development of both vertebrates and invertebrates. (nih.gov)
  • In hematopoietic stem cells , the MAPK/ERK pathway and PI3K/AKT/mTOR pathway regulate this transition. (wikipedia.org)
  • [5] The ability to regulate the cell cycle in response to external cues helps prevent stem cell exhaustion, or the gradual loss of stem cells following an altered balance between dormant and active states. (wikipedia.org)
  • During a complex biennial cycle, the female genital tract undergoes a series of alternations of increasing and decreasing, governed by equilibrium of proliferation and apoptotic phenomena. (mdpi.com)
  • In this study, p21-ELP-Bac and its control, ELP-p21, were used in cell proliferation studies using the pancreatic cancer cell lines Panc-1, MiaPaca-2, and S2013. (dovepress.com)
  • Here we focus on a hydroxyl-substituted analog (hydroxy-PP) of the known Src-family kinase inhibitor PP2 because it induced cell-specific morphological features distinct from all known kinase inhibitors in the collection. (biomedsearch.com)
  • We chose N2a cells for most of the experiments because these cells exhibit larger cytoplasmic areas and better attachment to plates than PC12 cells, allowing better morphological analysis of cell damage. (jneurosci.org)
  • The investigation of T cell tolerance in tumor-bearing host is limited by the nature of the experimental models because the persistent effect of tumor-derived factors makes it very difficult to investigate the role of defined cell populations. (jimmunol.org)
  • Therefore, in this study, we used a model with adoptive transfer of different cell populations isolated from tumor-bearing mice into tumor-free recipients. (jimmunol.org)
  • For instance, measurements of yeast replicative lifespan through micromanipulation involve very small populations of cells, which prohibit detection of rare mutations. (jove.com)
  • The current protocol takes advantage of magnetic sorting of surface-labeled yeast mother cells to obtain large enough populations of aging mother cells to quantify rare mutations through phenotypic selections. (jove.com)
  • Our results hint at possible existence of robust mechanism maintaining stable physiological viscosity of the cytoplasm, despite huge structural changes during cell cycle. (nature.com)
  • Ultimately, contractile cells replaced ciliary beating as the dominant mechanism for motility in larger animals. (pnas.org)
  • This is of relevance to the mechanism by which cancer metastasizes cell fate determination in stem cells. (csun.edu)
  • To begin to understand the mechanism of APP phosphorylation, we studied this process in differentiating neurons under normal physiological conditions. (jneurosci.org)
  • Invasion of non-phagocytic cells (i.e., epithelial, fibroblast and endothelial cells) involves either a trigger or a zipper mechanism mediated by the T3SS-1 or the invasin Rck, respectively. (frontiersin.org)
  • However, the mechanism of tumor-associated T cell tolerance remains unresolved. (jimmunol.org)
  • However, the exact nature of these cells as well as the mechanism of this phenomenon remains unclear. (jimmunol.org)
  • The nervous and immune systems consist of complex networks of cells that monitor signals and respond in a specific manner. (csun.edu)
  • Cytokines are a group of polypeptides used as signals between cells of the peripheral immune system and the central nervous system. (csun.edu)
  • Methods of measurement of membrane voltage and membrane currents in isolated cells, recording of random pulse signals from membrane channels on molecular level. (vutbr.cz)
  • Despite a functional T3SS-1, the wild-type bacteria seemed to use the same entry route as the mutant in our cell model. (frontiersin.org)
  • In view of a possible functional relationship between the renin-angiotensin system and leukocyte adhesion in the pathophysiology of coronary atherosclerosis, the present study was designed to investigate the effects of angiotensin II on the expression and modulation of E-selectin, VCAM-1, and ICAM-1 on human cardiac endothelial cells and on leukocyte adhesion. (ahajournals.org)
  • These experiments were performed with endothelial cells from epicardial coronary arteries and from microvessels of human hearts, since previous studies have shown functional differences between these cells in regard to their sensitivity to peptides and their ability to promote leukocyte adhesion. (ahajournals.org)
  • Multipotency or multidifferentiative potential , which is the ability to generate progeny of several distinct cell types , (for example glial cells and neurons ) as opposed to unipotency , which is the term for cells that are restricted to producing a single-cell type. (wikipedia.org)
  • We show that JNK-interacting protein-3 (JIP-3), a JNK scaffolding protein that does not bind APP, selectively increases APP phosphorylation, accumulation of pAPP into processes, and stimulates process extension in both neurons and COS-1 cells. (jneurosci.org)
  • Nevertheless, the nervous and immune systems can influence each other's activity because immune cells express neurotransmitter receptors, and neurons express cytokine receptors. (nature.com)
  • Unlike neurons and other types of glia, which are of neuroectodermal origin, microglia are macrophage-lineage cells derived from hematopoietic progenitors. (hindawi.com)
  • Granular cells of the DG sprout axons targeting neurons in the cornu ammonis 3 (CA3) area of the hippocampus, forming a neural trisynaptic circuit, an important part of the neural network in the hippocampus. (intechopen.com)
  • In contrast to its motogenic properties in the endothelium, Nogo-B blocks PDGF mediated migration of smooth muscle cells. (yale.edu)
  • The presented hydrogel fiber-based migration assays could be useful for studying cell behaviors under 3D coculture conditions and for drug screening and evaluation. (rsc.org)
  • During this migration, cells can use different modes of motility. (aps.org)
  • Single and collective cell migration are fundamental in development, maintenance and the progression of diseases across multicellular organisms. (aps.org)
  • Although the factors regulating adhesion and migration have been extensively studied, hyaluronan - a high molecular weight and microns long polysaccharide forming the pericellular matrix around migrating cells, has been mostly neglected. (aps.org)
  • While overexpression of hyaluronan has been shown to promote cell migration and the opposite for low expression levels, our preliminary data suggest a more complex relation. (aps.org)
  • We employed the model to recapitulate various aspects of individual and collective cell migration on deformable or stiff substrates. (aps.org)
  • We show in this study that macrophage SR-A deficiency inhibits tumor cell migration in a coculture assay. (jimmunol.org)
  • The predictive ability of this model can provide critical insights into diverse physiological and pathological phenomena. (aps.org)
  • Understanding the effects of neuroendocrine factors on NK cell activities during physiological and pathophysiological conditions may result in novel therapeutic strategies to enhance NK cell functions against tumors. (nature.com)
  • 2. The cell culture support of claim 1 wherein the partial removal of the photoresist by photolithography is effected by treatment of the photoresist on the cell culture support surface by irradiation through a photomask and developing a irradiated photoresist under conditions which result in a predetermined patterning of the photoresist on the cell culture support surface. (google.com)
  • Historically, microglia have been presumed to be quiescent under physiological conditions and activated only upon immune challenge or in response to neuronal damage or debris. (hindawi.com)
  • These cells are present in bone marrow and in small numbers in spleens of healthy mice, and under normal conditions differentiate into mature myeloid cells ( 7 ). (jimmunol.org)
  • Under these conditions cell surface oxygen consumption appears to be able to step in to oxidise cytoplasmic NADH to cytoplasmic NAD+, which then allows glycolysis and its associated ATP production. (blogspot.com)
  • 9) in which HSCs were recognized as an "[O.sub.2]-sensing cell type" because these cells are activated under hypoxic conditions. (thefreelibrary.com)
  • Transmission electron micrograph of an adult stem cell displaying typical ultrastructural characteristics. (wikipedia.org)
  • Scientific interest in adult stem cells is centered on their ability to divide or self-renew indefinitely, and generate all the cell types of the organ from which they originate, potentially regenerating the entire organ from a few cells. (wikipedia.org)
  • However, some researchers do not consider multipotency to be essential, and believe that unipotent self-renewing stem cells can exist. (wikipedia.org)
  • Symmetric division gives rise to two identical daughter stem cells, whereas asymmetric division produces one stem cell and one progenitor cell with limited self-renewal potential. (wikipedia.org)
  • [4] The niche the stem cell is found in plays a large role in maintaining quiescence. (wikipedia.org)
  • [4] Perturbed niches cause the stem cell to begin actively dividing again to replace lost or damaged cells until the niche is restored. (wikipedia.org)
  • Discoveries in recent years have suggested that adult stem cells might have the ability to differentiate into cell types from different germ layers. (wikipedia.org)
  • [6] Stem cells from the bone marrow, which is derived from mesoderm, can differentiate into liver, lung, GI tract and skin, which are derived from endoderm and mesoderm. (wikipedia.org)
  • [7] This phenomenon is referred to as stem cell transdifferentiation or plasticity. (wikipedia.org)
  • There is yet no consensus among biologists on the prevalence and physiological and therapeutic relevance of stem cell plasticity. (wikipedia.org)
  • Neural crest cells are a stem cell population that migrates from the neural tube early in development. (csun.edu)
  • The elsewhere uncharted security Patricia Neal is been a expression on stem, cell, and aging for romantically sixty others. (smokintex.com)
  • Neural stem/progenitor cells (NSPCs) exist throughout life in the subgranular zone (SGZ) of the DG, where they develop into granular cells and establish synaptic connections with nearby cells. (intechopen.com)
  • Neural stem/progenitor cells (NSPCs), which undergo neurogenesis, are present throughout life in the subgranular zone (SGZ) of the DG. (intechopen.com)
  • A metastasis map of human cancer cell lines. (harvard.edu)
  • This graph shows the total number of publications written about "Digestive System Physiological Phenomena" by people in this website by year, and whether "Digestive System Physiological Phenomena" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Digestive System Physiological Phenomena" by people in Profiles. (umassmed.edu)
  • The immune system and the nervous system are highly complex organs composed of various different cells that must interact with each other for proper function of the system. (nature.com)
  • In this review, we will focus on how the nervous system influences the activity of the immune system using natural killer (NK) cells as an example. (nature.com)
  • They migrate extensively throughout the embryo and form most of the head and peripheral nervous system, giving rise to sensory and sympathetic ganglia, heart regions, glia, head bones, teeth, muscle cells, sensory organs, melanocytes and other cell types. (csun.edu)
  • These three physiological aspects are particularly highlighted in embryonic development [ 1 , 2 ], and in organs submitted to cyclical variations. (mdpi.com)
  • Among these organs, the genital tracts of animals can be used such as models to understand the importance of the balance of these three phenomena. (mdpi.com)
  • However, they can also diffuse in the blood and bind to nonneuronal cells, or they can be released from efferent nerve endings directly in peripheral organs, such as the spleen, lymph nodes, glands, the intestine, and other organs. (nature.com)
  • Ultradian Growth Oscillations in Organs: Physiological Signal or Noise? (nhbs.com)
  • The model incorporates lamellipodial dynamics as well as mechanical interaction between cells and substrate in a rigorous manner. (aps.org)
  • We examine how cells communicate and function during fetal development. (stanford.edu)
  • Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell. (harvard.edu)
  • In this paper we address this topic by constant observation of nanoviscosity of HeLa cells cytoplasm during S, G2 and G1 phases after Aphidicolin synchronization. (nature.com)
  • The reported phenomenon may be of therapeutic relevance in AD. (jneurosci.org)
  • As such, many common diseases such as atherosclerosis, heart disease, cancer, macular degeneration and diabetes have a common signature of endothelial cell dysfunction. (yale.edu)
  • The binding of PSGL-1 on the leukocyte to P-selectin on the endothelial cell allows for the leukocyte to roll along the endothelial surface. (wikipedia.org)