Digestive System and Oral Physiological Phenomena
Reproductive and Urinary Physiological Phenomena
Musculoskeletal and Neural Physiological Phenomena
Circulatory and Respiratory Physiological Phenomena
Integumentary System Physiological Phenomena
Sports Nutritional Physiological Phenomena
Reproductive Physiological Phenomena
Physiological Phenomena
Elder Nutritional Physiological Phenomena
Urinary Tract Physiological Phenomena
Digestive System Physiological Phenomena
Ocular Physiological Phenomena
Nervous System Physiological Phenomena
Respiratory Physiological Phenomena
Skin Physiological Phenomena
Plant Physiological Phenomena
Cardiovascular Physiological Phenomena
Maternal Nutritional Physiological Phenomena
Nutritional Physiological Phenomena
Infant Nutritional Physiological Phenomena
E-CELL: software environment for whole-cell simulation. (1/842)
MOTIVATION: Genome sequencing projects and further systematic functional analyses of complete gene sets are producing an unprecedented mass of molecular information for a wide range of model organisms. This provides us with a detailed account of the cell with which we may begin to build models for simulating intracellular molecular processes to predict the dynamic behavior of living cells. Previous work in biochemical and genetic simulation has isolated well-characterized pathways for detailed analysis, but methods for building integrative models of the cell that incorporate gene regulation, metabolism and signaling have not been established. We, therefore, were motivated to develop a software environment for building such integrative models based on gene sets, and running simulations to conduct experiments in silico. RESULTS: E-CELL, a modeling and simulation environment for biochemical and genetic processes, has been developed. The E-CELL system allows a user to define functions of proteins, protein-protein interactions, protein-DNA interactions, regulation of gene expression and other features of cellular metabolism, as a set of reaction rules. E-CELL simulates cell behavior by numerically integrating the differential equations described implicitly in these reaction rules. The user can observe, through a computer display, dynamic changes in concentrations of proteins, protein complexes and other chemical compounds in the cell. Using this software, we constructed a model of a hypothetical cell with only 127 genes sufficient for transcription, translation, energy production and phospholipid synthesis. Most of the genes are taken from Mycoplasma genitalium, the organism having the smallest known chromosome, whose complete 580 kb genome sequence was determined at TIGR in 1995. We discuss future applications of the E-CELL system with special respect to genome engineering. AVAILABILITY: The E-CELL software is available upon request. SUPPLEMENTARY INFORMATION: The complete list of rules of the developed cell model with kinetic parameters can be obtained via our web site at: http://e-cell.org/. (+info)Titrating the effects of mitochondrial complex I impairment in the cell physiology. (2/842)
The mitochondrial oxidative phosphorylation system consists of five multimeric enzymes (complexes I-V). NADH dehydrogenase or complex I (CI) is affected in most of the mitochondrial diseases and in some neurodegenerative disorders. We have studied the physiological consequences of a partial CI inhibition at the cellular level. We used a genetic model (40% CI-inhibited human-ape xenomitochondrial cybrids) and a drug-induced model (0-100% CI-inhibited cells using different concentrations of rotenone). We observed a quantitative correlation between the level of CI impairment and cell respiration, cell growth, free radical production, lipid peroxidation, mitochondrial membrane potential, and apoptosis. We showed that cell death was quantitatively associated with free radical production rather than with a decrease in respiratory chain function. The results obtained with human xenomitochondrial cybrid cells were compatible with those observed in rotenone-induced 40% CI-inhibited cells. At high concentrations (5-6-fold higher than the concentration necessary for 100% CI inhibition), rotenone showed a second toxic effect at the level of microtubule assembly, which also led to apoptosis. The correlation found among all the parameters studied helped clarify the physiological consequences of partial CI inhibitions at the cellular level. (+info)Workshop conclusions & recommendations.(3/842)
(+info)Time-resolved analysis and visualization of dynamic processes in living cells. (4/842)
Recent development of in vivo microscopy techniques, including green fluorescent proteins, has allowed the visualization of a wide range of dynamic processes in living cells. For quantitative and visual interpretation of such processes, new concepts for time-resolved image analysis and continuous time-space visualization are required. Here, we describe a versatile and fully automated approach consisting of four techniques, namely highly sensitive object detection, fuzzy logic-based dynamic object tracking, computer graphical visualization, and measurement in time-space. Systematic model simulations were performed to evaluate the reliability of the automated object detection and tracking method. To demonstrate potential applications, the method was applied to the analysis of secretory membrane traffic and the functional dynamics of nuclear compartments enriched in pre-mRNA splicing factors. (+info)Hyaluronan and proteoglycans in ovarian follicles. (5/842)
Proteoglycans are macromolecules formed by a protein backbone to which one or more glycosaminoglycan side chains are co-valently attached. They can be secreted by the cells, retained at the cell surface, or stored in intracellular vacuoles. Hyaluronan is an extremely long glycosaminoglycan which, at variance with other glycosaminoglycans, is released into the extracellular matrix as a free polysaccharide not co-valently linked to a core protein. Both proteoglycans and hyaluronan influence many aspects of cell behaviour by multiple interactions with other molecules. They are involved in matrix formation, cell-cell and cell-matrix adhesion, cell proliferation and migration, and show co-receptor activity for growth factors. Both proteoglycan and hyaluranon synthesis change significantly during ovarian follicle development and atresia. This review describes the structure of these molecules and their possible function in ovarian physiology. (+info)Modeling electroporation in a single cell. I. Effects Of field strength and rest potential. (6/842)
This study develops a model for a single cell electroporated by an external electric field and uses it to investigate the effects of shock strength and rest potential on the transmembrane potential V(m) and pore density N around the cell. As compared to the induced potential predicted by resistive-capacitive theory, the model of electroporation predicts a smaller magnitude of V(m) throughout the cell. Both V(m) and N are symmetric about the equator with the same value at both poles of the cell. Larger shocks do not increase the maximum magnitude of V(m) because more pores form to shunt the excess stimulus current across the membrane. In addition, the value of the rest potential does not affect V(m) around the cell because the electroporation current is several orders of magnitude larger than the ionic current that supports the rest potential. Once the field is removed, the shock-induced V(m) discharges within 2 micros, but the pores persist in the membrane for several seconds. Complete resealing to preshock conditions requires approximately 20 s. These results agree qualitatively and quantitatively with the experimental data reported by Kinosita and coworkers for unfertilized sea urchin eggs exposed to large electric fields. (+info)Modeling electroporation in a single cell. II. Effects Of ionic concentrations. (7/842)
This study expands a previously developed model of a single cell electroporated by an external electric field by explicitly accounting for the ionic composition of the electroporation current. The previous model with non-specific electroporation current predicts that both the transmembrane potential V(m) and the pore density N are symmetric about the equator, with the same values at either end of the cell. The new, ion-specific case predicts that V(m) is symmetric and almost identical to the profile from the non-specific case, but N has a profound asymmetry with the pore density at the hyperpolarized end of the cell twice the value at the depolarized end. These modeling results agree with the experimentally observed preferential uptake of marker molecules at the hyperpolarized end of the cell as reported in the literature. This study also investigates the changes in intracellular ionic concentrations induced around an electroporated single cell. For all ion species, the concentrations near the membrane vary significantly, which may explain the electrical disturbances observed experimentally after large electric shocks are delivered to excitable cells and tissues. (+info)The osmotic migration of cells in a solute gradient. (8/842)
The effect of a nonuniform solute concentration on the osmotic transport of water through the boundaries of a simple model cell is investigated. A system of two ordinary differential equations is derived for the motion of a single cell in the limit of a fast solute diffusion, and an analytic solution is obtained for one special case. A two-dimensional finite element model has been developed to simulate the more general case (finite diffusion rates, solute gradient induced by a solidification front). It is shown that the cell moves to regions of lower solute concentration due to the uneven flux of water through the cell boundaries. This mechanism has apparently not been discussed previously. The magnitude of this effect is small for red blood cells, the case in which all of the relevant parameters are known. We show, however, that it increases with cell size and membrane permeability, so this effect could be important for larger cells. The finite element model presented should also have other applications in the study of the response of cells to an osmotic stress and for the interaction of cells and solidification fronts. Such investigations are of major relevance for the optimization of cryopreservation processes. (+info)
Entropy | Free Full-Text | On the Virtual Cell Transmission in Ultra Dense Networks
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Virtual Cells May Aid Drug Tests | WIRED
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Super-high sensitivity systems for detection and spectral analysis of ultraweak photon emission from biological cell cells and...
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transposase oligomers-encapsulated lipid-based nanoparticle-like protocells
Virtual cells provide new cancer insights / Featured news / Newsroom / The University of Newcastle, Australia
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Could These Protocells Tell Us About Earths Earliest Cells? | Science 2.0
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Directing Self-propelled Protocells To Deliver Drugs
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US Patent # 9,860,126. Method and system for coordinating cellular networks operation - Patents.com
The Horiba Xplora: Combining Confocal Microscopy and Raman Chemical Analysis | SelectScience
Scientists Create Possible Precursor to Life - Astrobiology
Parameter Estimation in Biological Cell Cycle Models Using Deterministic Optimization
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March 24, 2021 | UCLA Researchers Develop New, Noninvasive AI Method to Inspect Live Cells and Gain Critical Data | California...
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Cellular Physiology · Part One
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Nanophytoplankton
A physiological change in the cells must have occurred to allow this phenomenon. Low salinity is desirable for survival, as ... Also, availability of silicates, a nutrient for the organism, can affect photosynthetic efficiency and cell composition. ...
Timeline of medicine and medical technology
A new physiological phenomenon of Desired Metaplasia for regeneration of tissues and organs in vivo. Annals of NYAS 1998. Bynum ... 2016 - The first ever artificial pancreas was created 2019 - 3D-print heart from human patient's cells. 2020 - First vaccine ... Matapurkar B G. (1995). US international Patent 6227202 and 20020007223.medical use of Adult Stem cells. ... Adult stem cell use in regeneration of tissues and organs in vivo - B. G Matapurkar U.S . International Patent 1996 - Dolly the ...
Adult stem cell
This phenomenon is referred to as stem cell transdifferentiation or plasticity. It can be induced by modifying the growth ... There is yet no consensus among biologists on the prevalence and physiological and therapeutic relevance of stem cell ... these cells have the same ability as embryonic stem cells to develop into many different cell types. Olfactory stem cells hold ... such as mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, etc.). A great deal of adult stem cell ...
Heteroplasmy
The bottleneck exploits stochastic processes in the cell to increase in the cell-to-cell variability in mutant load as an ... When this occurs, it is known as reaching threshold, and it usually results in physiological consequences. Symptoms of severe ... An example of this phenomenon is Leber optic atrophy. Generally, individuals with this condition do not experience vision ... Many cell divisions and a great deal of time are required for a cell to accumulate enough mutant mitochondria to cause symptoms ...
Leukocyte extravasation
Flow-enhanced cell adhesion is still an unexplained phenomenon that could result from a transport-dependent increase in on- ... This topic was finally able to be studied thoroughly under physiological shear stress conditions using a typical flow chamber. ... Prabhakarpandian B, Shen MC, Pant K, Kiani MF (November 2011). "Microfluidic devices for modeling cell-cell and particle-cell ... Since the first experiments, a strange phenomenon was observed. Binding interactions between the white blood cells and the ...
Loop diuretic
Nephron remodeling increases the number of distal convoluted cells, principle cells, and intercalated cells. These cells have ... Prolonged usage of loop diuretics will also contributes to resistance through "braking phenomenon". This is the body ... physiological response to reduced extracellular fluid volume, where renin-angiotensin-aldosterone system will be activated ... Loop diuretics also inhibits NKCC2 at macula densa, reducing sodium transported into macula densa cells. This stimulates the ...
Contact guidance
... refers to a phenomenon for which the orientation of cells and stress fibers is influenced by geometrical ... on the surface with nano-micro-groove-like pattern and cell physiological effects". Chinese Science Bulletin. 54 (18): 3200- ... A similar effect can be obtained when cells are cultured on flat surfaces with lines of proteins printed on top (to which cells ... The Interplay Among Cell Traction, Fibrillar Network Deformation, Fibril Alignment, and Cell Contact Guidance". Journal of ...
Tissue expansion
When skin is stretched beyond its physiological limit, mechanotransduction pathways are activated. This leads to cell growth as ... Other biological phenomena such as tissue inflammation can also be considered expansion (see tissue inflammation below). Skin ... Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and ... well as to the formation of new cells. In some cases, this may be accomplished by the implantation of inflatable balloons under ...
Acrosome reaction
Part of the sperm's cell membrane then fuses with the egg cell's membrane, and the contents of the head sink into the egg. In ... This is referred to as spontaneous acrosome reaction (SAR). It is now known that in a certain sense, this phenomenon is ... In humans, on the other hand, it remains disputed where exactly the acrosome reaction is initiated in physiological ... It is then expressed as a percentage of the counted cells. For assessment with flow cytometry, the washed cells are incubated ...
Tissue stress
These are cells unspecific resistance modulation and influencing the speed of physiological processes occurring in the cell. ... Because of universality of this phenomenon it was named "the law of intermittent activity of functioning structures" ( ... Regulation of tissue cell mass by the TAS mechanism can be carried out in two physiological regimes - ether by formation of " ... Meanwhile, the cell stress concept considers only the first possibility. At the present moment, two physiological functions of ...
Margaret Ransone Murray
Murray, Margaret Ransone (1924). . Phenomena of Secretion in the Amitotic Cells of the Cricket Egg-follicle. Diss. Washington ... Murray, Margaret R. (1928). "The Calcium-Potassium Ratio in Culture Media for Planaria Dorotocephala". Physiological Zoology. 1 ... Their in vitro studies demonstrated that Schwann cells spiraled their surface cell membrane in jelly roll fashion around the ... Her master's thesis work was a study of the secretion of follicular cells of crickets In her thesis, she cites the influence of ...
Immunology
Antigen-presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate ... Many other ancient societies have references to this phenomenon, but it was not until the 19th and 20th centuries before the ... Neonates are said to be in a state of physiological immunodeficiency, because both their innate and adaptive immunological ... There is also some evidence that cell surface receptors on B cells and macrophages may detect sex hormones in the system. The ...
Fordyce spots
Most doctors consider this a normal physiological phenomenon and advise against treatment. Fordyce spots are completely benign ... Individual sebaceous cells are large, with central dark nuclei and abundant foamy cytoplasm. Sebaceous glands are normal ... The pathologist must be careful to differentiate such lesions from salivary neoplasms with sebaceous cells, such as sebaceous ...
Otto Frank (physiologist)
He also worked extensively on developing accurate methods to measure blood pressure and other physiological phenomena (e.g. ... J Mol Cell Cardiol. 22 (3): 253-277. doi:10.1016/0022-2828(90)91459-K. PMID 2192068. Norman Sharpe (2006). "Hypertension: from ... This law states that "Within physiological limits, the force of contraction is directly proportional to the initial length of ... J Mol Cell Cardiol 1990; 22: 253-277) Kritik der elastischen Manometer, 1903 Die Registrierung des Pulses durch einen ...
Otto Hutter
... have become iconic medical and physiological textbook images of these phenomena. Another major research interest was the ... His work developed to address the permeation of potassium ions in muscle cells. During a Rockefeller travelling scholarship in ... "An interview with Otto Hutter" (PDF). Physiological Society. Retrieved 29 July 2015.{{cite web}}: CS1 maint: url-status (link) ... Physiological Reports. 5 (6): e13165. doi:10.14814/phy2.13165. ISSN 2051-817X. PMC 5371556. PMID 28320898. The Guardian, ...
Arthur Henfrey (botanist)
In: Botanical and physiological memoirs…, 1853: The phenomenon of rejuvenescence in nature, especially in the life and ... He translated: On Vegetable Cells, by Carl von Nägeli; for the Ray Society, 1846. Chemical Field Lectures, by Julius Adolph ... Outlines of Structural and Physiological Botany, 1847. Reports and Papers on Botany, Ray Society, 1849. The Rudiments of Botany ... Principles of the Anatomy of the Vegetable Cell, by Hugo von Mohl, 1851. ...
Shin'ichi Ishiwata
Ishiwata's research interests go beyond the mechanical and physiological import of SPOC to bio-motile systems focusing on the ... It was an important breakthrough regarding a phenomenon that had been "almost completely ignored," he says. ... meiotic spindle and cells (cardiac, HeLa, etc.). He expects that the multiplex network of Chemo-Mechanical Feedback (CMF) loops ...
Breeding for heat stress tolerance
In many species it has been demonstrated that HSPs results in improved physiological phenomena such as photosynthesis, ... Similar analogy in human medical terms is high blood pressure or high body temperature or high white blood cells in body is an ... Evaluating physiological traits to complement empirical selection for wheat in warm environments. Euphytica 100:84-95., Fokar, ... At very high temperatures cause severe cellular injury and cell death may occur within short time, thus leading to a ...
DNA adenine methyltransferase identification
A DamID protocol for single cells has also been developed and applied to human cells. Single cell approaches can highlight the ... The targeted DamID (TaDa) approach uses the phenomenon of ribosome reinitiation to express Dam-fusion proteins at appropriately ... This allows for investigation into developmental or physiological processes in animal models. ... "Genome-wide maps of nuclear lamina interactions in single human cells". Cell. 163 (1): 134-147. doi:10.1016/j.cell.2015.08.040 ...
Myotonia congenita
J Neurol 254(2):257-258 Rüdel, R; Lehmann-Horn, F (1985). "Membrane changes in cells from myotonia patients". Physiological ... Trip J, Faber CG, Ginjaar HB, van Engelen BG, Drost G (2007) Warm-up phenomenon in myotonia associated with the V445M sodium ... When many action potentials are elicited subsequently more K+ is expelled from the cell into the transverse tubular system. As ... Lossin, Christoph (2013). "Nav1.4 slow-inactivation: Is it a player in the warm-up phenomenon of myotonic disorders?". Muscle ...
Bursting
Most cells will exhibit bursting if they are driven by a constant, subthreshold input and particular cells which are ... Physiological models show that for a given input the interspike and interburst timings are much more variable than the timing ... The study of bursting both directly and in how it takes part in other neural phenomena has been very popular since the ... Bursting is a very general phenomenon and is observed in many contexts in many neural systems. For this reason it is difficult ...
Protective autoimmunity
Additional work by the Schwartz group has shown that protective autoimmunity is a naturally occurring physiological phenomenon ... Other cell types, such as B cells and even neural progenitor cells, can promote regulation of immune response in the CNS. Stem ... a population of CNS-resident immune cells, which can act as phagocytes, and antigen-presenting cells. CD4+ T helper cells that ... dictate the profile of the subsequent T cell response. The interaction between the T cells and the microglia/dendritic cells ...
Jane Ingham
Auxin has a strengthening effect on the elongation growth of the cells. In the case of nutation phenomena, it is possible that ... Consequently, the concave and convex sides show profound physiological differences. The observation that in the hypocotyl the ... they were the first to separate cell walls from the root tip of broad beans. They analysed these cell walls and concluded that ... of protein was found in the cell walls of the plants examined.: 547, 569 Later researchers found protein in the cells but were ...
Sense
Such physiological and cognitive functions are generally not believed to give rise to mental phenomena or qualia, however, as ... A transmembrane protein receptor is a protein in the cell membrane that mediates a physiological change in a neuron, most often ... Receptor cells can be classified into types on the basis of three different criteria: cell type, position, and function. ... plants interpret and respond to these stimuli by a variety of hormonal and cell-to-cell communication pathways that result in ...
Cell theory
The term osmosis originated in 1827 and its importance to physiological phenomena realized, but it wasn't until 1877, when the ... Heredity information (DNA) is passed on from cell to cell. All cells have the same basic chemical composition. The cell was ... All known living things are made up of one or more cells All living cells arise from pre-existing cells by division. The cell ... All cells arise only from pre-existing cells However, the idea that all cells come from pre-existing cells had in fact already ...
Patch-sequencing
... a mutation of a gene coding for an ion channel which disrupts electrical phenomenon underlying physiological processes. ... Owing to the presence of cell or debris in the way of the pipette and a target cell the preparation will need to be slightly ... During recording cell viability needs to be maintained as being patch-clamped is stressful for the cell. Negative pressure is ... It is calculated as the sum of the NMS score from all broad cell types that does not match the assigned cell class. Quality ...
Bioelectromagnetics
The physiological phenomena of action potentials are possible because voltage-gated ion channels allow the resting potential ... a category of cell include neurons, muscle cells, and endocrine cells, as well as in some plant cells. These action potentials ... Funk, Richard HW; Monsees, Thomas K (2006). "Effects of Electromagnetic Fields on Cells: Physiological and Therapeutical ... Short-lived electrical events called action potentials occur in several types of animal cells which are called excitable cells ...
Satyabrata Sarkar
... , (born 1928 in Uttarpara near Calcutta), is a scientist, investigating physiological phenomena in plants and ... Naturforschung 36c,884-887, 1981 Mayee, C.D. & Sarkar, S.: The ultrastructure of Nicotiana tabacum cells infected with potato ... Physiological studies on diploid and polyploid varieties of banana. Science and Culture 16, 215,1950 Sarkar, S.: Versuche zur ... Cellwall-free protoplasts of plant cells (mainly of tobacco and Chinese cabbage) were infected with viruses or with their RNA ...
Autoinducer
During stationary growth phase when B. subtilis are at high cell density, approximately 10% of the cells in a population are ... This phenomenon was termed "autoinduction" because it involved a molecule (autoinducer) that accumulated in a growth medium and ... Sporulation, on the other hand, is a physiological response of B. subtilis to depletion of nutrients within a particular ... Dunny, G.M.; Leonard, B.A. (1997). "Cell-cell communication in gram-positive bacteria". Annu. Rev. Microbiol. 51: 527-564. doi: ...
Regeneration (biology)
Examples of physiological regeneration are the continual replacement of cells of the skin and repair of the endometrium after ... In order to prevent starvation a planarian will use their own cells for energy, this phenomenon is known as de-growth. Limb ... Second, the blastemal cells will undergo cell proliferation, patterning, cell differentiation and tissue growth using similar ... Macrophages are a type of repairing cell that devour dead cells and pathogens, and trigger other immune cells to respond to ...
Neodymium
J Cell Biol 4:475-478 Hosogi N, Nishioka H, Nakakoshi M (2015) Evaluation of lanthanide salts as alternative stains to uranyl ... This color-change phenomenon is highly prized by collectors.[citation needed] In combination with gold or selenium, red colors ... on Some Physiological Activities in Oilseed Rape during Calcium (Ca2+) Starvation". 10th International Rapeseed Congress. 2: ... and fuel cells. Among these technologies, permanent magnets are often used to fabricate high-efficiency motors, with neodymium- ...
Metabolism
doi:10.1016/j.cell.2016.12.039. PMC 5329766. PMID 28187287. Cooper GM (2000). "The Molecular Composition of Cells". The Cell: A ... Fell DA, Thomas S (October 1995). "Physiological control of metabolic flux: the requirement for multisite modulation". The ... Cellular phenomena Oncometabolism Reactome - Database of biological pathways KEGG - Collection of bioinformatics databases ... Proteins are also important in cell signaling, immune responses, cell adhesion, active transport across membranes, and the cell ...
Genomic imprinting
A similar imprinting phenomenon has also been described in flowering plants (angiosperms). During fertilization of the egg cell ... Tucci V, Isles AR, Kelsey G, Ferguson-Smith AC, Erice Imprinting Group (2019). "Genomic Imprinting and Physiological Processes ... of the parents and are maintained through mitotic cell divisions in the somatic cells of an organism. Appropriate imprinting of ... In germline cells the imprint is erased and then re-established according to the sex of the individual, i.e. in the developing ...
Senescence
... cells upon cell division, with the mother cell experiencing aging, while the daughter is rejuvenated. There is negligible ... Aging has been defined as "a progressive deterioration of physiological function, an intrinsic age-related process of loss of ... Dańko MJ, Kozłowski J, Schaible R (October 2015). "Unraveling the non-senescence phenomenon in Hydra". Journal of Theoretical ... Cloning from somatic cells rather than germ cells may begin life with a higher initial load of damage. Dolly the sheep died ...
Zymoblot
Physiological phenomena whether at the cellular or molecular level in living organisms are driven either directly or indirectly ... Cell fractions representing different parts of the cell (nuclei, mitochondria, lysosomes, peroxisomes, Golgi bodies, cytosol ... Furthermore, zymoblots can be very helpful in cytochemodissection studies aiming at localising enzymes within cells. ... physiological basis for disease resistance, developmental physiology and screening for commercially important enzymes and many ...
Psychological stress and sleep
To better understand this phenomenon, a study was conducted in Canada after a two-month state of emergency was declared (2020 ... Insulin resistance occurs when cells fail to use insulin efficiently which results in high blood sugar. Furthermore, when ... These all cause stressful times to have many physiological and behavioral impacts on one's diet. Furthermore, sleep deprivation ... Paradoxical insomnia is the phenomenon of a discrepancy between reported sleep duration and objective measurement of sleep. In ...
Listener fatigue
Outer hair cells serve as acoustic amplifiers for stimulation of the inner hair cells. Outer hair cells respond primarily to ... A natural physiological reaction to these threshold shifts is vasoconstriction, which will reduce the amount of blood reaching ... Common groups at risk of becoming victim to this phenomenon include avid listeners of music and others who listen or work with ... If these cells do not get this chance to recover, they are vulnerable to death. Temporary threshold shifts can result in ...
Beatrice M. Sweeney
To address this question, she studied single cells in Cartesian divers and found that rhythms occurred in single cells that ... She continued her research into circadian rhythms for the rest of her career, publishing her monograph Rhythmic Phenomena in ... By bringing dinoflagellates into culture and by defining their multiple photoperiodic responses, especially the physiological ... At that time, biological rhythms were known for a variety of assemblages of cells but Sweeney noted that when such rhythms ...
List of Puerto Rican scientists and inventors
There he conducted research that would make him the foremost expert on cell makeup of the human eye lens. Alcalá developed ... Bras has specialized in the interpretation of natural phenomena as random functions. He has been recognized for his use of ... The polymides are very strong in terms of their mechanical properties, yet degradable under standard physiological conditions ... Physiology is the study of life, specifically, how cells, tissues, and organisms function. She is a scientist who did her ...
Sigma-1 receptor
... signaling and cell survival". Cell. 131 (3): 596-610. doi:10.1016/j.cell.2007.08.036. PMID 17981125. S2CID 18885068. Kekuda R, ... A variety of specific physiological functions have been attributed to the σ1 receptor. Chief among these are modulation of Ca2+ ... It has been implicated in several phenomena, including cardiovascular function, schizophrenia, clinical depression, the effects ... doi:10.1016/j.cell.2018.09.048. PMC 6347410. PMID 30633901. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, et al ...
Synaptic fatigue
... although the exact mechanisms underlying the phenomenon are not completely understood. It is generally seen in mature cells at ... There have been several studies that suggest the reserve vesicles are seldom ever released in response to physiological stimuli ... Perforant path-granule cells (PP-GC) in the dentate gyrus of the hippocampus in adult rats have been shown to experience ... Because each presynaptic cell can link up to thousands of connections with other neurons, synaptic fatigue and its recovery can ...
Factor XIII
A subunits of human factor XIII are made primarily by platelets and other cells of bone marrow origin. B subunits are secreted ... Physiological Reviews. 91 (3): 931-72. doi:10.1152/physrev.00016.2010. PMID 21742792. S2CID 24703788. Laki K, Lóránd L ( ... while a stabilized clot is resistant to this phenomenon. Deficiency of Factor XIII (FXIIID), while generally rare, does occur, ... Dimers containing only A units also occur within cells such as platelets. Large quantities of singular B units (monomers) also ...
Hydraulic redistribution
This phenomenon has been documented in over sixty plant species spanning a variety of plant types (from herbs and grasses to ... Cell and Environment. 28 (2): 157-166. doi:10.1111/j.1365-3040.2004.01254.x. Oliveira, Rafael S.; Dawson, Todd E.; Burgess, ... there is an ongoing effort to continue the categorization of plants exhibiting this behaviour and adapting this physiological ... The ecological importance of hydraulically redistributed water is becoming better understood as this phenomenon is more ...
Physiologically based pharmacokinetic modelling
PBPK models try to rely a priori on the anatomical and physiological structure of the body, and to a certain extent, on ... is then the limiting factor to distribution in the various cells of the body. That is usually true for small lipophilic drugs. ... and chemical descriptions of the phenomena involved in the complex ADME processes. A large degree of residual simplification ... They are also parallel to physiome models, but do not aim at modelling physiological functions beyond fluid circulation in ...
Motion perception
... and decode information about the relative locations and attributes of phenomena in their spatial environment. Place cells work ... Although the details of the Hassenstein-Reichardt model have not been confirmed at an anatomical and physiological level, the ... ganglion cells receive inputs from bipolar cells and starburst amacrine cells. The DS ganglion cells respond to their preferred ... There are three known types of DS cells in the vertebrate retina of the mouse, ON/OFF DS ganglion cells, ON DS ganglion cells, ...
Enzyme inhibitor
Mobley H (13 March 2006). "How do antibiotics kill bacterial cells but not human cells?". Scientific American. 294 (6): 98. ... Physiological enzyme inhibition can also be produced by specific protein inhibitors. This mechanism occurs in the pancreas, ... Enzyme inactivation is generally explained as a chemical process involving several phenomena like aggregation, dissociation ... This causes the cell wall to lose strength and the bacteria to burst. In the figure, a molecule of penicillin (shown in a ball- ...
Beggiatoa
... wider filaments instead are disk-shaped with cell lengths from 0.10 to 0.90 times their cell width. In all of the cultured ... 2016-08-10). "Physiological and Metagenomic Analyses of Microbial Mats Involved in Self-Purification of Mine Waters ... causing the phenomenon called "bulking". Beggiatoa are also able to detoxify hydrogen sulfide in soil and have a role in the ... Species of Beggiatoa have cells up to 200 µm in diameter and they are one of the largest prokaryotes on Earth. The genera ...
ENDOG
"Endonuclease G promotes cell death of non-invasive human breast cancer cells". Experimental Cell Research. 312 (20): 4139-49. ... Kerr JF, Wyllie AH, Currie AR (Aug 1972). "Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue ... Apoptosis occurs in many physiological and pathological processes. It plays an important role during embryonal development as ... In epithelial cells, the nuclear localization and proapoptotic function of EndoG leads it to play a role in cell senescence. In ...
HSPA8
Cell. 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923. Imai Y ... Kerr JF, Wyllie AH, Currie AR (Aug 1972). "Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue ... Apoptosis occurs in many physiological and pathological processes. It plays an important role during embryonal development as ... an apoptotic cell undergoes structural changes including cell shrinkage, plasma membrane blebbing, nuclear condensation, and ...
Semantic memory
Thus, each cell of the matrix corresponds to the strength of the association between the row item and the column item. Learning ... There are still a number of memory phenomena for which TLC has no account, including why people are able to respond quickly to ... This strongly suggests that encoding of information leading to semantic memory does not have its physiological basis in the ... Each cell in the matrix is then transformed according to the equation: M t , d ′ = ln ( 1 + M t , d ) − ∑ i = 0 D P ( i , t ...
Origin of speech
The anatomical and physiological basis of human speech production: adaptations and exaptations. In M. Tallerman and K. .Gibson ... Onomatopoeia can explain the first couple of words all derived from natural phenomenon, but there is no explanation as to how ... even if its letters are invisible and its words are buried in the cells of our bodies." - Beadle, G.; Beadle, M. (1966). The ... The origin of speech refers to the general problem of the origin of language in the context of the physiological development of ...
Find-me signals
This phenomenon allows neighboring cells adjacent to the apoptotic cell sending out the find me signal to be engulfed without ... Schetinger, Morsch, Bonan, Wyse (2008). "NTPDase and 5'-nucleotidase activities in physiological and disease conditions: New ... Identified in breast cancer cells, this find-me signals is released by MCF-7 cells to attract the THP-1 monocytes. Other cells ... This has been observed in Jurkat cells (primary thymocytes), MCF-7 cells, and lung epithelial cells. Release is dependent upon ...
Linear no-threshold model
For example, a hot particle embedded in an organ (such as lung) results in a very high dose in the cells directly adjacent to ... In very high dose radiation therapy, it was known at the time that radiation can cause a physiological increase in the rate of ... a dose-response phenomenon characterized by low-dose stimulation and high-dose inhibition. Calabrese EJ (October 2015). "On the ... January 2012). "Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells". Proceedings of the ...
Heterochrony
This means that in progenesis, germ cell growth is accelerated relative to normal or in neoteny; while somatic cell growth is ... These factors are part of a complex phenomenon termed Island syndrome or Foster's rule. The mole salamander, a close relative ... Spicer, J. I.; Burggren, W. W. (2003). "Development of physiological regulatory systems: altering the timing of crucial events ... Cell. 134 (1): 25-36. doi:10.1016/j.cell.2008.06.030. PMID 18614008. Held, Lewis I. (2014). How the Snake Lost its Legs. ...
Macropsia
This lesion can be due to an ischemic cell death after an acute posterior cerebral infarction. The most prevalent research on ... Thus, when a patient reaches for an enlarged object, he or she is overcoming that physiological contraction. However, this ... The differences in visual phenomena, such as macropsia with slow motion versus macropsia without slow motion, may result from ... In the case of macropsia, the greater density of photoreceptor cells leads to greater stimulation making the object seem larger ...
Aequorin
Because the protein is large, it has a low leakage rate from cells compared to lipophilic dyes such as DiI. It lacks phenomena ... the first experiments involving the injection of the protein into the tissues of living animals to visualize the physiological ... and cultured cells. Cultured cells expressing the aequorin gene can effectively synthesize apoaequorin; however, recombinant ... Therefore it is necessary to add coelenterazine into the culture medium of the cells to obtain a functional protein and thus ...
Biomolecular condensate
Hardy WB (May 1899). "On the structure of cell protoplasm: Part I. The Structure produced in a Cell by Fixative and Post-mortem ... Thomson JA, Schurtenberger P, Thurston GM, Benedek GB (October 1987). "Binary liquid phase separation and critical phenomena in ... of the first discovered examples of a highly dynamic intracellular liquid biomolecular condensate with a clear physiological ... June 2018). "Protein Phase Separation: A New Phase in Cell Biology". Trends in Cell Biology. 28 (6): 420-435. doi:10.1016/j.tcb ...
Heme
These properties of free heme can sensitize a variety of cell types to undergo programmed cell death in response to pro- ... This phenomenon, which states that hemoglobin's oxygen binding affinity is inversely proportional to both acidity and ... However, due to its toxic properties, proteins such as Hemopexin (Hx) are required to help maintain physiological stores of ... Briefly, when cells are exposed to free radicals, there is a rapid induction of the expression of the stress-responsive heme ...
Alternaria dauci
These germination tubes will pierce host cell walls to initiate infection, or if wounds are present the pathogen may enter in ... a phenomenon that is sometimes mistaken for frost damage. The symptoms of this disease are also commonly confused with ... Physiological Plant Pathology. 19 (1): 7-IN9. doi:10.1016/s0048-4059(81)80003-3. Index Fungorum USDA ARS Fungal Database (CS1 ... Zinniol is highly hydrophobic, and has been detected inside cell walls after infection occurs, so it is assumed that the toxin ...
Nanoprobes and nanobiosensors for monitoring and imaging individual living cells
... and applications of these systems and their capacity for in vivo analysis and optical imaging at the single-cell level are ... Cell Culture Techniques / instrumentation* * Cell Culture Techniques / methods * Cell Physiological Phenomena* * Equipment ... Nanoprobes and nanobiosensors for monitoring and imaging individual living cells Nanomedicine. 2006 Mar;2(1):22-30. doi: ... These devices have the capacity to sense individual chemical species in specific locations within a cell. This article ...
Browsing by Subject "Maternal Nutritional Physiological Phenomena"
Membrane Potential, Mitochondrial | Harvard Catalyst Profiles | Harvard Catalyst
Cell Physiological Phenomena [G04]. *Membrane Potentials [G04.580]. *Membrane Potential, Mitochondrial [G04.580.550] ... Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy. Biomolecules ... Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway. Nat ... Metabolic Reprogramming of Glioblastoma Cells during HCMV Infection Induces Secretome-Mediated Paracrine Effects in the ...
Three Meals vs. Six Snacks - IDEA Health & Fitness Association
Frontiers | Modeling Depolarization Delay, Sodium Currents, and Electrical Potentials in Cardiac Transverse Tubules
To better understand the electrical behavior of T-tubules of cardiac cells in health and disease, this study addresses two ... To better understand the electrical behavior of T-tubules of cardiac cells in health and disease, this study addresses two ... T-tubules are invaginations of the lateral membrane of striated muscle cells that provide a large surface for ion channels and ... T-tubules are invaginations of the lateral membrane of striated muscle cells that provide a large surface for ion channels and ...
12-Hydroxyjasmonic acid glucoside causes leaf-folding of Samanea saman through ROS accumulation | Scientific Reports
Furthermore, we show that SPORK2 is indispensable for the JAG-triggered shrinkage of the motor cell. This is the first report ... Here, we report that JAG induces leaf-folding through accumulation of reactive oxygen species in the extensor motor cells of S ... It has been shown that the circadian rhythmic potassium flux from/into motor cells triggers cell shrinking/swelling to cause ... Although we did not perform calcium imaging experiments in S. saman, a similar phenomenon is presumed to be triggered by JAG in ...
Bacterial growth in multicellular aggregates leads to the emergence of complex life cycles: Current Biology
Direct single-cell biomass estimates for marine bacteria via Archimedes principle.. ISME J. 2017; 11: 825-828. View in Article ... Despite their ubiquity in nature, we lack an understanding of how these behaviors emerge from cellular-scale phenomena. Here, ... Exploiting fine-scale genetic and physiological variation of closely related microbes to reveal unknown enzyme functions. ... Multicellular behaviour enables cooperation in microbial cell aggregates.. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2019; 374 ...
Nonparametric functional mapping of quantitative trait loci underlying programmed cell death<...
Programmed cell death (PCD), a physiological cell suicide process, occurs during the development of most organisms and is, ... Programmed cell death (PCD), a physiological cell suicide process, occurs during the development of most organisms and is, ... Programmed cell death (PCD), a physiological cell suicide process, occurs during the development of most organisms and is, ... Programmed cell death (PCD), a physiological cell suicide process, occurs during the development of most organisms and is, ...
Taste Before Tasting: Development of a Virtual Tongue to Characterise the Organoleptic Profiles of Mediterranean Ingredients
VIRTUOUS embraces a disruptive paradigm concerning modelling physiological and pathological phenomena. The VIRTUOUS vision ... tongue has the potential to become a tool to help clinicians in preparing a diet to target specific cell receptors and cell ... Each taste represents a different nutritional or physiological need. ... between food chemical compounds and relative taste receptors trigger a subsequent cascade of events involving receptor cells ...
Publications 8.41 - PTB.de
8.41,Algorithms,Cell Physiological Phenomena,Membrane Proteins,Membrane Proteins: chemistry,Membranes,Membranes: chemistry, ... We study two mechanisms for the formation of protein patterns near membranes of living cells by mathematical modelling. Self- ... whereas self-organization results in a pattern wavelength comparable to the typical cell size of 100 microm within a few ...
Bioenergetics
... species are key factors that strongly affect the cellular redox state and regulate various physiological and cellular phenomena ... Fluorescent sensor proteins capable of measuring in situ pH in animal cells have been reported. However, these proteins require ... However, such fluorescent probes are unsuitable for use in the cells of photosynthetic organisms because they require ... pH is one of the most critical physiological parameters determining vital cellular activities, such as photosynthetic ...
Synaptic tau: A pathological or physiological phenomenon? | Acta Neuropathologica Communications | Full Text
... axonal retraction and cell death. Alongside synaptic pathology, recent data suggest that Tau has physiological roles in the pre ... We collate here the myriad of emerging interactions and physiological roles of synaptic Tau, and discuss the current evidence ... analysis of Tau-interacting proteins suggests roles in scaffolding and transport with high enrichment at synapses and cell ...
Models of hippocampus - Scholarpedia
Physiological phenomena. Models of hippocampus address several important physiological phenomena observed within the ... recent data suggests that place cells may not depend upon grid cell firing. The changes in place cell responses after movement ... Models of hippocampus simulate physiological phenomena or behavioral functions of the hippocampus, using the techniques of ... The place cell responses in region CA1 have been modeled using arrays of sensory features linked to place cell responses by ...
Portal LIS - Localizador de Informação em Saúde
ATSDR - Asbestos Expert Panel - Premeeting Comments
... may partially model a physiological prophylaxis in the lung, cell test systems may inadvertently introduce a non-representative ... The only draw backs to and in vitro approach is that these techniques do no take lung clearance phenomena into consideration ... from inflammatory cells and not target cells. However, asbestos fiber can generate ROS spontaneously in cell-free systems. ... Topic #1: Physiological Fate of Asbestos and Vitreous Fibers less than 5 Microns in Length.. What is the expected physiological ...
Cells | Free Full-Text | Nerve, Muscle, and Synaptogenesis
If focal proteolysis is a key mechanism in mediating cell-cell interaction at the NMJ, this would hardly be a novel phenomenon ... The involvement of proteinases has been extensively reviewed, owing to their importance for a multitude of physiological and ... Cell Dev. Biol. 2009, 25, 161-195. [Google Scholar] [CrossRef] [PubMed]. *Burden, S.J. SnapShot: Neuromuscular Junction. Cell ... Werle, M.J. Cell-to-cell signaling at the neuromuscular junction: The dynamic role of the extracellular matrix. Ann. N. Y. Acad ...
Zinc prevents profit loss from heat stress - All About Feed
On a physiological level, cells lining the gut increase their permeability - a phenomenon known as leaky gut. Heat stress also ... These cells are responsible for keeping toxins inside the gut and out of the bloodstream. "Enterocytes - the cells lining the ... "As a result of the vasoconstriction, the cells lining the gut suffer from hypoxia and die; this allows toxins such as LPS to ... The thermo-neutral zone for pigs can range from 18°C to 24°C, depending on the animals size, physiological status, air ...
Paolo Provenzano - Research output
- [email protected]
Kim, D. H., Provenzano, P. P., Smith, C. L. & Levchenko, A., Apr 2012, In: Journal of Cell Biology. 197, 3, p. 351-360 10 p.. ... Provenzano, P. P., Eliceiri, K. W. & Keely, P. J., Nov 2009, In: Trends in Cell Biology. 19, 11, p. 638-648 11 p.. Research ... Provenzano, P. P., Eliceiri, K. W., Inman, D. R. & Keely, P. J., 2010, In: Current Protocols in Cell Biology. SUPPL. 47, p. ... Engineering three-dimensional collagen matrices to provide contact guidance during 3D cell migration. ...
New insights into store-independent Ca 2+ entry: Secretory pathway calcium ATPase 2 in normal physiology and cancer<...
Physiological Phenomena Medicine & Life Sciences 42% * Carcinogenesis Medicine & Life Sciences 31% * Cell Proliferation ... SPCA2-induced store-independent Ca2+ entry (SICE) plays essential roles in many important physiological processes, while ... SPCA2-induced store-independent Ca2+ entry (SICE) plays essential roles in many important physiological processes, while ... SPCA2-induced store-independent Ca2+ entry (SICE) plays essential roles in many important physiological processes, while ...
CYTOOplates™ 96 RW Motility A | CYTOO
cell shape, cell function, cell physiological phenomena, ciliogenesis. J. Cell Biol. 2010;191(2):233-236. ... tumor cells, Micropatterns, H shape, Y shape, cell division, neoplasms, cell adhesion, cell line, cell shape, Cell polarity ... cell fate, cell division, cell shape, cell membrane, Cell polarity, actin dynamics, average distribution of actin-binding ... cilia, ciliogenesis, retinal dystrophy, actins, cytoskeleton, cell cycle, cell division, cell line, cell movement, cell shape, ...
MeSH | Reproductive Physiological Phenomena (D055703)
Phosphatidylserine Asymmetry and Cell Survival | The New York Academy of Sciences
He has a long-standing interest in the molecular and cellular biology of physiological cell death (apoptosis) and in the ... Those interests have led to the characterization of the phenomenon of "innate apoptotic immunity," and to the identification of ... Ca2+ influx into apoptotic cells results in the redistribution of PS to the cell surface where it marks the dying cells for ... Apoptotic cells are recognized by phagocytes and neighboring cells, and trigger a profound repertoire of affirmative signaling ...
MH DELETED MN ADDED MN
Child Nutritional Physiological Phenomena G7.610.220 G7.203.650.220 Chimera B1.50.50.530 B1.650.85 Chimerin 1 D12.776.402.150. ... B-Cell Activating Factor D12.644.276.972.61 D12.776.467.972.61 D23.529.972.61 B-Cell-Specific Activator Protein D12.776.930.626 ... Animal Nutritional Physiological Phenomena G7.610.161 G7.203.650.161 Animals, Congenic B1.50.50.157.40 B1.50.50.199.40 Animals ... Sports Nutritional Physiological Phenomena G7.610.830 G7.203.650.830 Spouse Abuse I1.198.240.856.575.500 I1.880.735.900.688.500 ...
Reconsidering the evidence for learning in single cells | eLife
Single cells are believed to be incapable of complex forms of learning, but reconsideration of historical studies and more ... which sought to establish links between physiological and psychological phenomena. Davis primarily conducted ... and human iNKT cells. Strikingly, we found that regulatory iNKT cells, such as adipose iNKT cells, undergo blunted activation, ... Single cells continue to surprise us. Robert Hooke, peering through his microscope in the 17th century, first likened cells to ...
Professor Nick Di Girolamo
Medical Research Future Fund (MRFF) Accelerator Research Stem Cell Program. Stem cells for sight: building the pathway from the ... Notably, we have also identified uncommon and unreported non-tumourgenic transformation phenomena on the corneal surface, some ... of which are pathological and some that might be physiological, i.e., attempt to self-resolve. Our goal is to characterise ... Identifying markers for these rare but important cell is key, and to this end, we are performing cutting-edge single cell RNA ...
HER1-4 protein concentrations in normal breast tissue from breast cancer patients are expressed by the same profile as in the...
Sensory, computational and cognitive components of human colour constancy. - Department of Experimental Psychology
Science Clips - Volume 10, Issue 37, October 2, 2018
This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation ... Using cell biological, biochemical, and genetic tools, we reveal that influenza A virus (IAV) infection induces global ... that ultimately cause global transcriptional downregulation of physiological transcripts, an effect influencing antiviral ... Exercise capacity and clinical outcomes in adults followed in the Cooperative Study of Sickle Cell Disease (CSSCD)External. ...
Ben-Gurion University of the Negev - Research output
- Ben-Gurion University Research Portal
Data science in cell imaging. Driscoll, M. K. & Zaritsky, A., 1 Apr 2021, In: Journal of Cell Science. 134, 7, jcs254292.. ... Diagnostic and clinical significance of fetal cells in maternal blood circulation. Bashiri, A., Sheiner, E. & Mazor, M., 15 Jun ... Physiological Phenomena 23% 21 Scopus citations * Deviance and Risk on Holiday: An Ethnography of British Tourists in Ibiza. ...
ProcessesProteinOccursPathological conditionsMolecularCirculatoryPathwaysIntracellularApoptosisMitochondrialTissuesRegulateCellularHumansMembraneBehavioralEnzymeMeSHGenesCycleGene expressionBiologyMetabolicBloodstreamMetabolismAbstractSomatic cellsProteinsPermeabilityEpithelialVirulenceAnatomicalReceptorsGenomicGeneticEndothelial cellMechanismMechanismsPluripotentResponsesPhaseAsymmetricMicroenvironmentHumanDeficiencyDeclineVivoActivationWidely
Processes7
- Self-assembly produces periodic protein patterns on a spatial scale below 0.1 microm in a few seconds followed by extremely slow coarsening, whereas self-organization results in a pattern wavelength comparable to the typical cell size of 100 microm within a few minutes suggesting different biological functions for the two processes. (ptb.de)
- SPCA2-induced store-independent Ca 2+ entry (SICE) plays essential roles in many important physiological processes, while unbalanced SICE leads to enhanced cell proliferation and tumorigenesis. (elsevier.com)
- Physiological processes, factors, properties and characteristics pertaining to REPRODUCTION . (liu.edu)
- The cellular processes involved in adjustments to the MITOCHONDRIAL VOLUME, content, and activity, that depend on the energy demands of the cell. (uams.edu)
- The next step which is necessary for developing a systems biology that deals with systemic phenomena is to expand the existing and develop new methodologies that are appropriate to characterize intercellular processes and interactions without omitting the causal underlying molecular mechanisms. (who.int)
- While the adipocyte has been studied for many years and remarkable insights have been gained about some processes, many areas of the physiology of the fat cell remain unexplored. (diabetesjournals.org)
- The cerebral microvascular system is key to a large variety of cerebral processes, including oxygen and nutrient delivery to brain cells as well as blood flow regulation as a function of neural activity. (univ-toulouse.fr)
Protein9
- We study two mechanisms for the formation of protein patterns near membranes of living cells by mathematical modelling. (ptb.de)
- We have mapped the protein concentrations of HER1-4 in breast cancer tissue, autologous reference tissue, normal breast tissue and serum samples, to see whether non-cancer cells from these patients express a protein profile indicating general activation. (hu-berlin.de)
- Great care should be taken when interpreting the results of protein localisation and quantitative gene expression patterns using fluorescent proteins in experiments involving intracellular physiological change. (biomedcentral.com)
- Because of the importance of IP3 receptors, the ubiquitin / proteasome pathway, and the Bcl-2 protein family to cell biology, this work is significant to both our understanding of normal physiology, and also to diseases, such as cancer and neurodegeneration. (upstate.edu)
- This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation of an intrinsically disordered region (IDR) of NS1 expressed by the 1918 pandemic IAV strain. (cdc.gov)
- Through research, they discovered a way to repair the protein and heal cell damage. (k2dweb.com)
- Both are key components of the systems physiology toolbox, which allows study of the interactions between a condition (e.g., nutrition, physiological state) with tissue gene/protein expression and the associated changes in biological functions. (oregonstate.edu)
- Physiological functions of the imprinted Gnas locus and its protein variants Galpha(s) and XLalpha(s) in human and mouse. (medlineplus.gov)
- G-protein coupled receptors (GPCRs) take part in a wide range of vital regulations of our physiological actions. (mdm2-inhibitors.com)
Occurs7
- Here, we report that JAG induces leaf-folding through accumulation of reactive oxygen species in the extensor motor cells of S. saman , and this occurs independently of plant hormone signaling. (nature.com)
- The rhythm of this phenomenon is not affected by environmental conditions and occurs even under continuous light/dark conditions. (nature.com)
- Programmed cell death (PCD), a physiological cell suicide process, occurs during the development of most organisms and is, typically, a complex dynamic trait. (elsevier.com)
- Division of the vegetative cell occurs asymmetrically forming the mother cell and pre-spore, both containing a copy of the genome. (biomedcentral.com)
- This is a classic adaptive response that enables cells to adjust to their external environment and occurs during chronic exposure to drugs and perhaps in physiological and pathological situations. (upstate.edu)
- This phenomenon occurs in response to both physiologic levels of shear stress and a pathologic stimulus, particular matter exposure. (cdc.gov)
- Scientists have established that this physiological phenomenon occurs when we sleep 1,2 . (elitenaturalhealthcare.com)
Pathological conditions3
- Since deformability is such a fundamental characteristics of blood cells, deviations in normal cell deformability can contribute to a range of pathological conditions, such as microvascular occlusion, tissue necrosis and organ failure, observed in diseases such as malaria caused by Plasmodium falciparum. (ubc.ca)
- The demonstration that some disease states are mirrored by gene expression profiles in blood cells has stimulated the analyses of gene expression changes in blood cells in different physiological and pathological conditions, including aging [ 1 , 2 ]. (aging-us.com)
- This phenomenon does not apply to pathological conditions and does not require special treatment. (babymagazinclub.com)
Molecular4
- Describe plant biology at genetic, molecular, physiological, and organismal levels to integrate plant functionalities in a hierarchical manner, from individual cells to the biosphere. (cornell.edu)
- Fluorescent proteins are powerful molecular biology tools that have been used to study the subcellular dynamics of proteins within live cells for well over a decade. (biomedcentral.com)
- Program in Molecular and Integrative Physiological Sciences Department of Environmental Health. (bvsalud.org)
- The course will build upon knowledge acquired through prior studies of cell and molecular biology, general physiology and human anatomy, as we focus primarily on the central nervous system. (coursera.org)
Circulatory1
- This biophysical characteristic is particularly relevant for cells in the circulatory system, such as red blood cells and white blood cells, because deformability determines the capacity for these cells to transit through the microvasculature. (ubc.ca)
Pathways5
- We annotated PETs to pathways of KEGG database and compared the murine B16F1 melanoma transcriptome with three non-melanoma murine transcriptomes (Melan-a2 melanocytes, E14 embryonic stem cells, and E17.5 embryo). (biomedcentral.com)
- Upregulation of cell cycle progression, MAPK, and PI3K/Akt pathways were more limited to certain region(s) of the pathway. (biomedcentral.com)
- Recovery of cells from one of the activated pathways of regulated cell death. (nih.gov)
- been associated with or connected with vital physiological pathways. (bio2009.org)
- In a process called signal transduction, G proteins trigger a complex network of signaling pathways that ultimately influence many cell functions. (medlineplus.gov)
Intracellular5
- However, such fluorescent probes are unsuitable for use in the cells of photosynthetic organisms because they require photoexcitation that may change intracellular conditions and induce autofluorescence, primarily in chlorophylls. (jbc.org)
- A living cell has many different receptors on its surface by the activation of which information is transferred to the intracellular spaces. (dojindo.com)
- IP3 is an intracellular messenger molecule formed at the plasma membrane when hormones, neurotransmitters or drugs stimulate cells. (upstate.edu)
- This might be done by increasing or prolonging the intracellular level of active drug, by blocking the capacity of the cell to repair the drug's damage, or by interfering with other survival measures (such as replica- tion delay) instituted by the cell during this critical period. (cdc.gov)
- In the body, NAMPT exists in two forms: an intracellular form, which regulates the production of nicotinamide adenine dinucleotide (NAD+), an important molecule for the generation of energy in the cell. (eurekalert.org)
Apoptosis1
- The highly correlated results unmistakably point to a systematic downregulation of mitochondrial activities, which we hypothesize aims to downgrade the mitochondria-mediated apoptosis and the dependency of cancer cells on angiogenesis. (biomedcentral.com)
Mitochondrial1
- The first concerns genes coding for mitochondrial energy metabolism, to see whether changes in blood cells mirror those found in other tissues and may thus correlate with the global decrease in maximum oxygen uptake. (aging-us.com)
Tissues5
- Levels of PEX in these vascularized tissues suggest that it interacts with endothelial cell alphavbeta3 where it serves as a natural inhibitor of MMP-2 activity, thereby regulating the invasive behavior of new blood vessels. (embl.de)
- Staining of such tissues with TSQ has demonstrated that zinc ions play very important roles in neuronal cell death, endocrine functions, and other physiological phenomena. (dojindo.com)
- Microarray development changed the way biologists approach the holistic study of cells and tissues. (oregonstate.edu)
- Sometimes the phenomenon of 'additional' tissues is observed in children. (babymagazinclub.com)
- genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
Regulate3
- Reactive oxygen species are key factors that strongly affect the cellular redox state and regulate various physiological and cellular phenomena. (jbc.org)
- Epithelial cells have the ability to regulate paracellular permeability dynamically in response to extracellular stimuli. (cdc.gov)
- Looking at the nucleus accumbens - a brain region that regulates motivated behaviors - of both the socially impaired and healthy, 'control", mice, the researchers identified lower NAD+ levels and problems with the enzyme Sirtuin-1, an enzyme that depends on NAD+ to regulate the expression of genes involved in helping the cell regulate itself in response to stressors. (eurekalert.org)
Cellular9
- Despite their ubiquity in nature, we lack an understanding of how these behaviors emerge from cellular-scale phenomena. (cell.com)
- pH is one of the most critical physiological parameters determining vital cellular activities, such as photosynthetic performance. (jbc.org)
- It carries messages that help in muscle contraction, nerve cell signal transmission, hormone secretion, immune cell activation, and other cellular functions. (dojindo.com)
- The effects of IP3 are mediated by proteins called IP3 receptors, channels that govern the release of calcium ions from the endoplasmic reticulum into the cell cytosol: this "calcium mobilization" is a central part of many cellular functions. (upstate.edu)
- This is exciting because the ubiquitin / proteosome pathway is currently one of the "hot areas" of cell biology - is it becoming increasingly apparent that this pathway is the mechanism by which many important cellular proteins and misfolded proteins in the endoplasmic reticulum are degraded and is of major relevance to diseases (e.g. cancer, neurodegeneration, diabetes). (upstate.edu)
- Through the selection of suitable clinically useful alkylating agents (those dependent on active cellular transport for cell penetration) and appropriate MX scheduling, an enhanced therapeutic ratio might be achieved, potentially increasing the clinical usefulness of these alkylating agents. (cdc.gov)
- Multiple and different cellular activities have already been related to the PP-InsPs, but an over-arching hypothesis sights them as performing as an user interface between energy fat burning capacity and cell-signaling [3,5,6]. (immune-source.com)
- Viral infection perturbs host cells and can be used to uncover regulatory mechanisms controlling cellular responses and susceptibility to infections. (cdc.gov)
- A special class of eukaryotic TFs, called pioneer factors, are the first to bind during cellular differentiation and reprogramming, facilitating the binding of non-pioneer transcription factors and initiating gene cascades associated with the new cell type. (genestogenomes.org)
Humans2
- One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
- that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
Membrane5
- T-tubules are invaginations of the lateral membrane of striated muscle cells that provide a large surface for ion channels and signaling proteins, thereby supporting excitation-contraction coupling. (frontiersin.org)
- To better understand the electrical behavior of T-tubules of cardiac cells in health and disease, this study addresses two largely unanswered questions regarding their electrical properties: (1) the delay of T-tubular membrane depolarization and (2) the effects of T-tubular sodium current on T-tubular potentials. (frontiersin.org)
- Transverse (T-)tubules are deep invaginations of the lateral membrane of skeletal and cardiac muscle cells. (frontiersin.org)
- DVar7 can allosterically insert into the tumor cell membrane in the acidic tumor microenvironment to enhance the tumor uptake of liposomes and prolong the retention time of liposomes in tumor. (dovepress.com)
- We report that increased membrane septin-2 localization mediates decreases in paracellular permeability by altering cortical actin arrangement in human airway epithelial cells. (cdc.gov)
Behavioral4
- Models of hippocampus simulate physiological phenomena or behavioral functions of the hippocampus , using the techniques of computational neuroscience . (scholarpedia.org)
- Other functional models assume specific response patterns such as place cells and predict behavioral results such as goal-directed behavior on this basis. (scholarpedia.org)
- In fact, there is a substantial body of rigorous scientific evidence which shows that what is widely regarded as animal cognition is also found in plants, down to its physiological and behavioral basis. (springer.com)
- There are a growing number of reports which correlate synthetic cannabinoids and acute behavioral and physiological effects including acute kidney injury, convulsions, and sudden death. (springeropen.com)
Enzyme3
- A fragment of MMP-2, which comprises the C-terminal hemopexin-like domain, termed PEX, prevents this enzyme binding to alphavbeta3 and blocks cell surface collagenolytic activity. (embl.de)
- Initial GI symptoms are thought to be due to the virus's S1 spike protein's binding to the angiotensin-converting enzyme 2 receptors , which are abundant in GI epithelial cells. (medscape.com)
- These receptors are essential in human beings physiologically, taking part in the rules of all of our physiological activities such as for example neurotransmission, enzyme launch, inflammation or chemotaxis, aswell as our feeling of vision, taste and smell, by sensing endogenous or environmental stimuli through binding suitable ligands and AZD-3965 IC50 transducing related sign into cells typically through combined heterotrimeric G proteins. (mdm2-inhibitors.com)
MeSH1
- Une recherche documentaire a été effectuée dans PubMed de 1980 à 2021 en utilisant diverses combinaisons de termes MeSH comme tabac, diabète, hypertension, dyslipidémie, trouble dépressif majeur, trouble bipolaire, schizophrénie. (bvsalud.org)
Genes9
- Melanin biosynthesis genes were solely expressed in the cells of melanocytic origin, indicating the feasibility of using the PET approach for transcriptome comparison. (biomedcentral.com)
- Despite the critical nature of these cell-to-cell interactions, much more is known about genes regulating EC versus MC function. (wustl.edu)
- Another study was specifically focused on the identification of genes related to increased longevity and thus compared gene expression profiles in blood cells from nonagenarians with their middle-age offspring using the partners of the offspring as population controls [ 4 ]. (aging-us.com)
- Using cell biological, biochemical, and genetic tools, we reveal that influenza A virus (IAV) infection induces global transcriptional defects at the 3' ends of active host genes and RNA polymerase II (RNAPII) run-through into extragenic regions. (cdc.gov)
- The systems root these phenomena have already been examined [7]C[11] thoroughly, but it is probable that many from the genes and regulatory systems involved have however to be discovered. (bio2009.org)
- A few of these focus on genes are portrayed specifically in Ha sido cells aswell Lurasidone (SM13496) IC50 such as the ICM of blastocysts. (bio2009.org)
- In individual Ha sido cells 581 genes have already been defined as Oct3/4-focus on genes, whereas 963 genes have already been discovered in mouse Ha sido cells. (bio2009.org)
- The appearance patterns of the genes in ZHTc6 cells and ZHBTc4 cells had been analyzed separately utilizing a k-means clustering algorithm and grouped into ten clusters (Amount 1B, C). Top panels display the expression adjustments of specific genes within a 3D landscaping map, whereas lower sections show the design of averaged gene appearance changes and the amount of genes grouped into each cluster. (bio2009.org)
- Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
Cycle1
- When vegetative cells encounter conditions of stress such as starvation the sporulation cycle is induced. (biomedcentral.com)
Gene expression5
- The work in my laboratory focuses on the establishment of specific cell fates using genomics to decipher interactions between chromatin and developmental signaling cascades, between genomes and rapidly evolving cell types, and between genomic copy number variation and gene expression. (stanford.edu)
- As sporulation initiates, cells undergo an asymmetric division leading to differential gene expression in the small prespore and large mother cell compartments. (biomedcentral.com)
- Gene expression is controlled temporally by a subset of sigma factors in both the developing spore and mother cell. (biomedcentral.com)
- Blood cells provide an easily available tissue and gene expression profiles from whole blood samples appear to mirror disease states and some aspects of the aging process itself. (aging-us.com)
- Careful regulation of gene expression is crucial to the health of an organism, as misregulation can have severe physiological consequences. (genestogenomes.org)
Biology7
- Journal of Cell Biology. (umn.edu)
- Current Protocols in Cell Biology. (umn.edu)
- Trends in Cell Biology. (umn.edu)
- Frontiers in Cell and Developmental Biology. (edu.au)
- There are many situations in medicine and biology where it is desirable to sort cells in a heterogeneous sample based on their mechanical deformability, which can potentially serve as a proxy for morphology or pathology. (ubc.ca)
- Address correspondence and reprint requests to Departments of Cell Biology and Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461. (diabetesjournals.org)
- Up to now, research in to the biology of inositol phosphate kinases continues to be well-served by hereditary research, including gene knock-outs both in microorganisms and cultured cells. (immune-source.com)
Metabolic3
- Metabolic Reprogramming of Glioblastoma Cells during HCMV Infection Induces Secretome-Mediated Paracrine Effects in the Microenvironment. (harvard.edu)
- Facultative multicellular behaviors expand the metabolic capacity and physiological resilience of bacteria. (cell.com)
- Intro Inositol phosphate kinases (IP3K, IPMK, ITPK1, IP5K, IP6K and PPIP5K) perform several biological procedures through their involvement inside a carefully-regulated, metabolic network that changes phospholipase C-derived Ins(1,4,5)P3 into a range of even more extremely phosphorylated cell-signaling substances [1C3]. (immune-source.com)
Bloodstream2
- These cells are responsible for keeping toxins inside the gut and out of the bloodstream. (allaboutfeed.net)
- Glucose is the main source of fuel for our cells and the amount of glucose present in our bloodstream is controlled by Insulin, a hormone created by the pancreas. (ultrahuman.com)
Metabolism2
- Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy. (harvard.edu)
- Antiresorptive drugs (ARD) are bone metabolism patients, resulting in increased bone density, reduced risk modulators widely used in patients with some physiological of fractures and improved quality of life of individuals4,5. (bvsalud.org)
Abstract2
- abstract = "Recent studies in secretory pathway calcium ATPases (SPCA) revealed novel functions of SPCA2 in interacting with store-operated Ca2+ channel Orai1 and inducing Ca2+ influx at the cell surface. (elsevier.com)
- We communicate through symbols which are generally commonly-agreed-upon abstract representations of real-world objects and phenomena. (philosophytoday.in)
Somatic cells2
- Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization. (bvsalud.org)
- The process that reverts CELL NUCLEI of fully differentiated somatic cells to a pluripotent or totipotent state. (bvsalud.org)
Proteins6
- Fluorescent sensor proteins capable of measuring in situ pH in animal cells have been reported. (jbc.org)
- Bioinformatics analysis of Tau-interacting proteins suggests roles in scaffolding and transport with high enrichment at synapses and cell junctions. (biomedcentral.com)
- However, since most zinc ions are strongly combined with proteins, the concentration of free zinc ions in a cell is at the millimolar level or lower. (dojindo.com)
- Background: Galectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the anticancer activities of T lymphocytes and natural killer cells. (diamond.ac.uk)
- Two transcription elements, (and (variant homeobox proteins) [15], [16] are recognized to play essential assignments in mouse Ha sido cells. (bio2009.org)
- In blastocysts, Oct3/4 proteins is more loaded in the ICM than in trophectoderm cells, however in later blastocysts Oct3/4 proteins is even more loaded in primitive endoderm than in the ICM [18] also. (bio2009.org)
Permeability1
- On a physiological level, cells lining the gut increase their permeability - a phenomenon known as leaky gut. (allaboutfeed.net)
Epithelial2
- With every respiratory effort, airway epithelial cells are exposed to both physiologic as well as pathologic stimuli, and regulation of the epithelial barrier in response to these stimuli is crucial to respiratory function. (cdc.gov)
- The resulting changes in barrier function in response to septin-2 redistribution have a significant impact on the ability of the apical ligand, epidermal growth factor, to interact with its receptor, epidermal growth factor receptor, which is segregated to the basolateral side in airway epithelial cells. (cdc.gov)
Virulence2
- The lowest passage WNV available were used for crow virulence studies to avoid incorporating confounding cell-culture-related genetic substitutions. (cdc.gov)
- Deregulated RNAPII leads to expression of aberrant RNAs (3' extensions and host-gene fusions) that ultimately cause global transcriptional downregulation of physiological transcripts, an effect influencing antiviral response and virulence. (cdc.gov)
Anatomical1
- MCs, a perivascular cell population that provides structural support to EC tube networks, can be split into subclasses, including smooth muscle cells and pericytes, based on the anatomical location of the MC population within the vascular network. (wustl.edu)
Receptors5
- The interactions between food chemical compounds and relative taste receptors trigger a subsequent cascade of events involving receptor cells linked to the nervous system, ultimately resulting in the perception of a specific taste. (ercim.eu)
- Our primary focus at the moment is analyzing IP3 receptor down-regulation - a remarkable phenomenon by which IP3 receptors are rapidly depleted from cells when they are stimulated (see diagram). (upstate.edu)
- 58. Pearce, M.M., Wang, Y., Kelley, G.G. and Wojcikiewicz, R.J.H. (2007) SPFH2 mediates the ERAD of IP3 receptors and other substrates in mammalian cells. (upstate.edu)
- Furthermore, human being FPR expression continues to be observed in several distinct cells and cell types ([6]C[7] and sources therein), indicating a much broad distribution of the receptors and their significant role in vivo physiologically. (mdm2-inhibitors.com)
- With a particular focus in pancreatic cancer, the company's mission is to develop novel oncology therapies founded on technology that selectively targets overexpressed receptors on cancer cells. (missouritechnology.com)
Genomic2
- These differences in gene activation based on the gene's parent of origin are caused by a phenomenon called genomic imprinting. (medlineplus.gov)
- This approach can be adapted to any pioneer factor, cell type, genomic locus, and repressive histone modification. (genestogenomes.org)
Genetic1
- As in previous lectures, I will illustrate some of the basic human genetic phenomena through case studies, in this case ranging from calico cats to the human genetic disorders of Angelman and Prader-Willi syndromes. (coursera.org)
Endothelial cell1
- To build a functionally stable blood vessel that is able to withstand changes in shear stress and modulate vascular tone requires cooperation between two cell types: the endothelial cell (EC) and the mural cell (MC). (wustl.edu)
Mechanism5
- The mechanism behind HER2 amplification is unknown, but may be a patho-physiological phenomenon caused by continuous stimulation and activation of the HER1-4 system. (hu-berlin.de)
- This dissertation presents an improved microfiltration strategy performed using the microfluidic ratchet mechanism, which relies on the deformation of individual cells through micrometer-scale tapered constrictions. (ubc.ca)
- This work demonstrates the utility of the ratchet mechanism for cell sorting by developing a microfluidic device to sort red blood cells based on deformability. (ubc.ca)
- But why patients have long-term GI sequelae is probably a whole different physiological mechanism," Trindade said. (medscape.com)
- The prin- ciple has two aspects: (1) that complex mental phenomena are formed from simple elements derived ultimately from sensations and (2) that the mechanism by which these are formed depends on similarity and/or repeated juxtaposition of the simple elements in space and time. (virginia.edu)
Mechanisms2
- Angiogenesis depends on both cell adhesion and proteolytic mechanisms. (embl.de)
- The difficulties in model development for these endpoints can be attributed to the complex mechanisms relevant to the toxicity phenomena. (rutgers.edu)
Pluripotent2
- The appearance of Oct3/4 is fixed to pluripotent embryonic and germline cells [17]. (bio2009.org)
- Organoids from human pluripotent cells can be used to model cerebral cortical development. (jcbose.ac.in)
Responses1
- You can watch the film on the screen, and get so absorbed, that you'll have emotional and physiological responses, but the movie isn't real. (karenshanley.com)
Phase2
Asymmetric1
- I shall discuss about our very recent findings of wobbling motion in 183Au nucleus, which is a common phenomenon for an asymmetric top in the classical world but an extremely rare one in atomic nuclei. (jcbose.ac.in)
Microenvironment2
- Tumor microenvironment (TME), supporting the survival and development of cancer cells, has the special physical and chemical characteristic, such as low concentration of oxygen and low pH value, which not only play a key role in tumor progression and metastasis but also has an obvious impact on the therapeutic efficacy of tumors. (dovepress.com)
- 1-4 In the acidic microenvironment of tumors, weakly alkaline drug molecules are easily protonated, preventing them from entering tumor cells and thus causing drug resistance. (dovepress.com)
Human8
- The relationships between DNA damage from UV radiation, alkylating drugs and the methylated xanthines (MX) have been studied in normal and malignant rodent and human cells. (cdc.gov)
- A comparison of the level of DNA excision repair (repair replication and unscheduled DNA synthesis) confirms that some forms of alkylating- agent damage (probably mono-filar DNA adducts) are less completely removed by both normal and malignant rodent cells than by their human counterparts, rendering rodent cells more susceptible to the toxic potential of unexcised lesions. (cdc.gov)
- Human cells appear capable of excising more DNA damage, rendering them somewhat less susceptible to enhancement of cytotoxicity by MX. (cdc.gov)
- This resistance of human cells is only quanti- tative, however, since 2 human cancer cell lines (HeLa and HT-29) could be sensitized to a variety of alkylating agents by appropriate concentrations of MX. (cdc.gov)
- This phenomenon indicates that the N-formyl group is not essential for ligand binding to AZD-3965 IC50 human FPRs. (mdm2-inhibitors.com)
- Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
- The correspondence is usually clear but there's a significant degree of fuzziness involved owing to unavoidable subjectivity inherent in even the most standardised definitions as well as differential human perception and understanding of objects and phenomena. (philosophytoday.in)
- We now turn our attention from the tangible (human neuroanatomy) to the physiological as we explore the means by which neurons generate, propagate and communicate electrical signals. (coursera.org)
Deficiency1
- Results of enzymic analysis provided here suggest that a previously defined deficiency of aspartase (AspA) accounts for this phenomenon rather than an elevated oxaloacetate pool. (microbiologyresearch.org)
Decline1
- The extremely high physiological stress around calving leads Selleckchem HSP inhibitor to decline of fertility rates and prolonged number of open days, which are risk factors of rentability. (ainhibitor.com)
Vivo2
- The fabrication, operating principle, and applications of these systems and their capacity for in vivo analysis and optical imaging at the single-cell level are discussed. (nih.gov)
- In this work, our goal is to develop models for hemodynamics and mass transport in the brain microcirculation, which can be later coupled with in-vivo measurement to understand and solve physiological problems involved in pathologies. (univ-toulouse.fr)
Activation1
- Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway. (harvard.edu)
Widely1
- Circadian rhythmic leaf-folding, called nyctinasty, is a widely observed physiological behavior of leguminous plants 1 , 2 , wherein the plants open their leaves in the morning and fold them in the evening. (nature.com)