Cell Physiological Phenomena: Cellular processes, properties, and characteristics.Dental Physiological Phenomena: Physiological processes and properties of the DENTITION.Digestive System and Oral Physiological Phenomena: Properties and processes of the DIGESTIVE SYSTEM and DENTITION as a whole or of any of its parts.Reproductive and Urinary Physiological Phenomena: Physiology of the human and animal body, male or female, in the processes and characteristics of REPRODUCTION and the URINARY TRACT.Musculoskeletal and Neural Physiological Phenomena: Properties, and processes of the MUSCULOSKELETAL SYSTEM and the NERVOUS SYSTEM or their parts.Circulatory and Respiratory Physiological Phenomena: Functional processes and properties characteristic of the BLOOD; CARDIOVASCULAR SYSTEM; and RESPIRATORY SYSTEM.Integumentary System Physiological Phenomena: The properties and relationships and biological processes that characterize the nature and function of the SKIN and its appendages.Sports Nutritional Physiological Phenomena: Nutritional physiology related to EXERCISE or ATHLETIC PERFORMANCE.Reproductive Physiological Phenomena: Physiological processes, factors, properties and characteristics pertaining to REPRODUCTION.Physiological Phenomena: The functions and properties of living organisms, including both the physical and chemical factors and processes, supporting life in single- or multi-cell organisms from their origin through the progression of life.Elder Nutritional Physiological Phenomena: Nutritional physiology of adults aged 65 years of age and older.Urinary Tract Physiological Phenomena: Properties, functions, and processes of the URINARY TRACT as a whole or of any of its parts.Musculoskeletal Physiological Phenomena: Processes and properties of the MUSCULOSKELETAL SYSTEM.Virus Physiological Phenomena: Biological properties, processes, and activities of VIRUSES.Digestive System Physiological Phenomena: Properties and processes of the DIGESTIVE SYSTEM as a whole or of any of its parts.Blood Physiological Phenomena: Physiological processes and properties of the BLOOD.Adolescent Nutritional Physiological Phenomena: Nutritional physiology of children aged 13-18 years.Ocular Physiological Phenomena: Processes and properties of the EYE as a whole or of any of its parts.Nervous System Physiological Phenomena: Characteristic properties and processes of the NERVOUS SYSTEM as a whole or with reference to the peripheral or the CENTRAL NERVOUS SYSTEM.Respiratory Physiological Phenomena: Physiological processes and properties of the RESPIRATORY SYSTEM as a whole or of any of its parts.Skin Physiological Phenomena: The functions of the skin in the human and animal body. It includes the pigmentation of the skin.Prenatal Nutritional Physiological Phenomena: Nutrition of FEMALE during PREGNANCY.Plant Physiological Phenomena: The physiological processes, properties, and states characteristic of plants.Bacterial Physiological Phenomena: Physiological processes and properties of BACTERIA.Cardiovascular Physiological Phenomena: Processes and properties of the CARDIOVASCULAR SYSTEM as a whole or of any of its parts.Maternal Nutritional Physiological Phenomena: Nutrition of a mother which affects the health of the FETUS and INFANT as well as herself.Child Nutritional Physiological Phenomena: Nutritional physiology of children aged 2-12 years.Nutritional Physiological Phenomena: The processes and properties of living organisms by which they take in and balance the use of nutritive materials for energy, heat production, or building material for the growth, maintenance, or repair of tissues and the nutritive properties of FOOD.Infant Nutritional Physiological Phenomena: Nutritional physiology of children from birth to 2 years of age.Raynaud Disease: An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.African Americans: Persons living in the United States having origins in any of the black groups of Africa.Indians, North American: Individual members of North American ethnic groups with ancient historic ancestral origins in Asia.Science: The study of natural phenomena by observation, measurement, and experimentation.Asian Americans: Persons living in the United States having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent.Mexican Americans: Persons living in the United States of Mexican descent.United StatesHispanic Americans: Persons living in the United States of Mexican (MEXICAN AMERICANS), Puerto Rican, Cuban, Central or South American, or other Spanish culture or origin. The concept does not include Brazilian Americans or Portuguese Americans.Morphogenesis: The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.Anagallis: A plant genus of the family PRIMULACEAE that contains anagallosides, which are molluscacidal triterpenoid saponins.Plant Development: Processes orchestrated or driven by a plethora of genes, plant hormones, and inherent biological timing mechanisms facilitated by secondary molecules, which result in the systematic transformation of plants and plant parts, from one stage of maturity to another.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Arabidopsis: A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.Arabidopsis Proteins: Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Glyoxysomes: Microbodies which occur in plant cells, and in some eukaryotic microorganisms, and which contain enzymes of the glyoxylate cycle. (Singleton and Stainsbury, Dictionary of Microbiology and Molecular Biology, 2nd ed)Microbodies: Electron-dense cytoplasmic particles bounded by a single membrane, such as PEROXISOMES; GLYOXYSOMES; and glycosomes.Peroxisomes: Microbodies which occur in animal and plant cells and in certain fungi and protozoa. They contain peroxidase, catalase, and allied enzymes. (From Singleton and Sainsbury, Dictionary of Microbiology and Molecular Biology, 2nd ed)Plant Leaves: Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)Organoids: An organization of cells into an organ-like structure. Organoids can be generated in culture. They are also found in certain neoplasms.Ricinus: A plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. The seed of Ricinus communis L. is the CASTOR BEAN which is the source of CASTOR OIL; RICIN; and other lectins.Isocitrate Lyase: A key enzyme in the glyoxylate cycle. It catalyzes the conversion of isocitrate to succinate and glyoxylate. EC 18.104.22.168.
E-CELL: software environment for whole-cell simulation. (1/842)MOTIVATION: Genome sequencing projects and further systematic functional analyses of complete gene sets are producing an unprecedented mass of molecular information for a wide range of model organisms. This provides us with a detailed account of the cell with which we may begin to build models for simulating intracellular molecular processes to predict the dynamic behavior of living cells. Previous work in biochemical and genetic simulation has isolated well-characterized pathways for detailed analysis, but methods for building integrative models of the cell that incorporate gene regulation, metabolism and signaling have not been established. We, therefore, were motivated to develop a software environment for building such integrative models based on gene sets, and running simulations to conduct experiments in silico. RESULTS: E-CELL, a modeling and simulation environment for biochemical and genetic processes, has been developed. The E-CELL system allows a user to define functions of proteins, protein-protein interactions, protein-DNA interactions, regulation of gene expression and other features of cellular metabolism, as a set of reaction rules. E-CELL simulates cell behavior by numerically integrating the differential equations described implicitly in these reaction rules. The user can observe, through a computer display, dynamic changes in concentrations of proteins, protein complexes and other chemical compounds in the cell. Using this software, we constructed a model of a hypothetical cell with only 127 genes sufficient for transcription, translation, energy production and phospholipid synthesis. Most of the genes are taken from Mycoplasma genitalium, the organism having the smallest known chromosome, whose complete 580 kb genome sequence was determined at TIGR in 1995. We discuss future applications of the E-CELL system with special respect to genome engineering. AVAILABILITY: The E-CELL software is available upon request. SUPPLEMENTARY INFORMATION: The complete list of rules of the developed cell model with kinetic parameters can be obtained via our web site at: http://e-cell.org/. (+info)
Titrating the effects of mitochondrial complex I impairment in the cell physiology. (2/842)The mitochondrial oxidative phosphorylation system consists of five multimeric enzymes (complexes I-V). NADH dehydrogenase or complex I (CI) is affected in most of the mitochondrial diseases and in some neurodegenerative disorders. We have studied the physiological consequences of a partial CI inhibition at the cellular level. We used a genetic model (40% CI-inhibited human-ape xenomitochondrial cybrids) and a drug-induced model (0-100% CI-inhibited cells using different concentrations of rotenone). We observed a quantitative correlation between the level of CI impairment and cell respiration, cell growth, free radical production, lipid peroxidation, mitochondrial membrane potential, and apoptosis. We showed that cell death was quantitatively associated with free radical production rather than with a decrease in respiratory chain function. The results obtained with human xenomitochondrial cybrid cells were compatible with those observed in rotenone-induced 40% CI-inhibited cells. At high concentrations (5-6-fold higher than the concentration necessary for 100% CI inhibition), rotenone showed a second toxic effect at the level of microtubule assembly, which also led to apoptosis. The correlation found among all the parameters studied helped clarify the physiological consequences of partial CI inhibitions at the cellular level. (+info)
Workshop conclusions & recommendations.(3/842)(+info)
Time-resolved analysis and visualization of dynamic processes in living cells. (4/842)Recent development of in vivo microscopy techniques, including green fluorescent proteins, has allowed the visualization of a wide range of dynamic processes in living cells. For quantitative and visual interpretation of such processes, new concepts for time-resolved image analysis and continuous time-space visualization are required. Here, we describe a versatile and fully automated approach consisting of four techniques, namely highly sensitive object detection, fuzzy logic-based dynamic object tracking, computer graphical visualization, and measurement in time-space. Systematic model simulations were performed to evaluate the reliability of the automated object detection and tracking method. To demonstrate potential applications, the method was applied to the analysis of secretory membrane traffic and the functional dynamics of nuclear compartments enriched in pre-mRNA splicing factors. (+info)
Hyaluronan and proteoglycans in ovarian follicles. (5/842)Proteoglycans are macromolecules formed by a protein backbone to which one or more glycosaminoglycan side chains are co-valently attached. They can be secreted by the cells, retained at the cell surface, or stored in intracellular vacuoles. Hyaluronan is an extremely long glycosaminoglycan which, at variance with other glycosaminoglycans, is released into the extracellular matrix as a free polysaccharide not co-valently linked to a core protein. Both proteoglycans and hyaluronan influence many aspects of cell behaviour by multiple interactions with other molecules. They are involved in matrix formation, cell-cell and cell-matrix adhesion, cell proliferation and migration, and show co-receptor activity for growth factors. Both proteoglycan and hyaluranon synthesis change significantly during ovarian follicle development and atresia. This review describes the structure of these molecules and their possible function in ovarian physiology. (+info)
Modeling electroporation in a single cell. I. Effects Of field strength and rest potential. (6/842)This study develops a model for a single cell electroporated by an external electric field and uses it to investigate the effects of shock strength and rest potential on the transmembrane potential V(m) and pore density N around the cell. As compared to the induced potential predicted by resistive-capacitive theory, the model of electroporation predicts a smaller magnitude of V(m) throughout the cell. Both V(m) and N are symmetric about the equator with the same value at both poles of the cell. Larger shocks do not increase the maximum magnitude of V(m) because more pores form to shunt the excess stimulus current across the membrane. In addition, the value of the rest potential does not affect V(m) around the cell because the electroporation current is several orders of magnitude larger than the ionic current that supports the rest potential. Once the field is removed, the shock-induced V(m) discharges within 2 micros, but the pores persist in the membrane for several seconds. Complete resealing to preshock conditions requires approximately 20 s. These results agree qualitatively and quantitatively with the experimental data reported by Kinosita and coworkers for unfertilized sea urchin eggs exposed to large electric fields. (+info)
Modeling electroporation in a single cell. II. Effects Of ionic concentrations. (7/842)This study expands a previously developed model of a single cell electroporated by an external electric field by explicitly accounting for the ionic composition of the electroporation current. The previous model with non-specific electroporation current predicts that both the transmembrane potential V(m) and the pore density N are symmetric about the equator, with the same values at either end of the cell. The new, ion-specific case predicts that V(m) is symmetric and almost identical to the profile from the non-specific case, but N has a profound asymmetry with the pore density at the hyperpolarized end of the cell twice the value at the depolarized end. These modeling results agree with the experimentally observed preferential uptake of marker molecules at the hyperpolarized end of the cell as reported in the literature. This study also investigates the changes in intracellular ionic concentrations induced around an electroporated single cell. For all ion species, the concentrations near the membrane vary significantly, which may explain the electrical disturbances observed experimentally after large electric shocks are delivered to excitable cells and tissues. (+info)
The osmotic migration of cells in a solute gradient. (8/842)The effect of a nonuniform solute concentration on the osmotic transport of water through the boundaries of a simple model cell is investigated. A system of two ordinary differential equations is derived for the motion of a single cell in the limit of a fast solute diffusion, and an analytic solution is obtained for one special case. A two-dimensional finite element model has been developed to simulate the more general case (finite diffusion rates, solute gradient induced by a solidification front). It is shown that the cell moves to regions of lower solute concentration due to the uneven flux of water through the cell boundaries. This mechanism has apparently not been discussed previously. The magnitude of this effect is small for red blood cells, the case in which all of the relevant parameters are known. We show, however, that it increases with cell size and membrane permeability, so this effect could be important for larger cells. The finite element model presented should also have other applications in the study of the response of cells to an osmotic stress and for the interaction of cells and solidification fronts. Such investigations are of major relevance for the optimization of cryopreservation processes. (+info)
Entropy | Free Full-Text | On the Virtual Cell Transmission in Ultra Dense Networks
Ultra dense networks (UDN) are identified as one of the key enablers for 5G, since they can provide an ultra high spectral reuse factor exploiting proximal transmissions. By densifying the network infrastructure equipment, it is highly possible that each user will have one or more dedicated serving base station antennas, introducing the user-centric virtual cell paradigm. However, due to irregular deployment of a large amount of base station antennas, the interference environment becomes rather complex, thus introducing severe interferences among different virtual cells. This paper focuses on the downlink transmission scheme in UDN where a large number of users and base station antennas is uniformly spread over a certain area. An interference graph is first created based on the large-scale fadings to give a potential description of the interference relationship among the virtual cells. Then, base station antennas and users in the virtual cells within the same maximally-connected component are grouped
2009 | Strongly heterogeneous dynamics in the interior of living biological cells | Home
Fasciculus:Biological cell.svg - Vicipaedia
Licet hoc documentum exscribere vel distribuere vel demutare sub GNU Liberarum Litterarum Licentiae conditionibus in editione 1.2 aut in ulla editione recentiori a Fundatione Liberarum Programmationis Partium publicata; praeterquam Sectiones Immutabiles et Verba Involucra Adversa et Aversa. Licentiae exemplar praesto est in sectione intitulata GNU Free Documentation License.http://www.gnu.org/copyleft/fdl.htmlGFDLGNU Free Documentation Licensetruetrue ...
CELLmicrocosmos.org - 5.3 Aligning Molecules
KESS InHouse The Magnolia Trees Outdoor Throw Pillow | Staples
VCAC: Through the Virtual Cell -- A Guided Flythrough: A Closer Look
Through the Virtual Cell : A Closer Look The processes going on within our virtual cell occur at specific cellular locations. To emphasize the connections between these processes, the Closer Look section has been divided according the cellular organelles associated with the functions being illustrated. To see the Flash movie for the following sequences of images, click here.. ...
Here, we show that the multikinase inhibitor SO alone diminishes pancreatic CSC-like tumor cells, but depletes them significantly only in combination with the phytochemical SF. The major CSC characteristics of the CSChigh MIA-PaCa2 and CSClow BxPc-3 cell lines have been described in our recent study (6). In the present work, we describe the presence of two cell populations, which can be found in CSChigh but not in CSClow cells, namely, spheroidal cells and fibroblast-like adherent cells. These two populations may correspond to primitive CSCs and differentiated daughter cells, suggesting differentiation potential of in vitro cultured pancreatic CSCs. SO targeted both cell subpopulations present in the CSChigh cell line in vitro. This was due to the induction of apoptosis, DNA fragmentation, and downregulation of antiapoptotic proteins. In addition, SO strongly diminished clonogenicity, spheroid formation, and ALDH1 activity. Most importantly, the concentration of 20 μmol/L SO was selectively ...
Virtual Cells May Aid Drug Tests | WIRED
Sandwalk: The Virtual Cell Animation Collection
Honesty compels me to add that I was a member of the committee that wrote the current (1983) IUPAC-IUB Recommendations on Nomenclature and Symbolism for Amino Acids and Peptides, in which you will find, in Table 1, the words The systematic names and formulas given refer to hypothetical forms in which amino groups are unprotonated and carboxyl groups are undissociated. This convention is useful to avoid various nomenclatural problems but should not be taken to imply that these structures represent an appreciable fraction of the amino-acid molecules. I tried but failed to convince the rest of the committee that hypothetical was a euphemism that should be replaced by fictitious or nonexistent. After more than 30 years its hard to be certain, but I think the second sentence had not originally been in the draft but was added in an effort to keep me quiet. To be fair to the committee, I think the rest of the document shows correct structures, except for lapse with glutathione.. Delete ...
Self-organization of tetrapyrrole constituents to give a photoactive protocell - Chemical Science (RSC Publishing)
A tandem combinatorial reaction of four acyclic, colorless compounds (two α-aminoketones and two diones; one polar and one nonpolar for each) in aqueous solution (30 mM each, 60 °C, pH 7, 24 h) containing lipid vesicles and with or without quinones and solar illumination affords a distribution of up to 538 p
CELLmicrocosmos.org - download
TEL - Thèses en ligne - Models and algorithms for metabolic networks: elementary modes and precursor sets
In this PhD, we present some algorithms and complexity results for two general problems that arise in the analysis of a metabolic network: the search for elementary modes of a network and the search for minimal precursors sets. Elementary modes is a common tool in the study of the cellular characteristic of a metabolic network. An elementary mode can be seen as a minimal set of reactions that can work in steady state independently of the rest of the network. It has therefore served as a mathematical model for the possible metabolic pathways of a cell. Their computation is not trivial and poses computational challenges. We show that some problems, like checking consistency of a network, finding one elementary mode or checking that a set of reactions constitutes a cut are easy problems, giving polynomial algorithms based on LP formulations. We also prove the hardness of central problems like finding a minimum size elementary mode, finding an elementary mode containing two given reactions, counting the
Necessary and sufficient conditions for protocell growth | SpringerLink
EmerginC Protocell Eye Cream Ingredients and Reviews
Here be dragons
PAOLO FRIL, chairman and chief scientific officer of GeneDupe, based in San Melito, California, is a man with a dream. That dream is a dragon in every home.. GeneDupes business is biotech pets. Not for Dr Fril, though, the mundane cloning of dead moggies and pooches. He plans a range of entirely new animals or, rather, of really quite old animals, with the twist that even when they did exist, it was only in the imagination.. Making a mythical creature real is not easy. But GeneDupes team of biologists and computer scientists reckon they are equal to the task. Their secret is a new field, which they call virtual cell biology . Biology and computing have a lot in common, since both are about processing information in one case electronic; in the other, biochemical. Virtual cell biology aspires to make a software model of a cell that is accurate in every biochemical detail. That is possible because all animal cells use the same parts list mitochondria for energy processing, the endoplasmic ...
Worldwide Cellular Network Operator KPIs by Signals and Systems Telecom at Market Reports Hub
Super-high sensitivity systems for detection and spectral analysis of ultraweak photon emission from biological cell cells and...
BRS Phys 1 Cell Physiology Flashcards - Cram.com
Chemistry & Living Systems
If it takes up space and has mass then it matters - actually it is matter. There are numerous terms that relate to the basic or fundamental unit of matter - the atom. ELEMENTS are pure substances which means that they consist of only one type of atom. A COMPOUND consists of two or more different kind of atoms or ions in definite proportions ...
Humans as Self-Constructing Living Systems: A Developmental Perspectiv
Cell Cycle: Meiosis Biology Lecture Materials from the Virtual Cell Biology Classroom
transposase oligomers-encapsulated lipid-based nanoparticle-like protocells
Population covered by mobile cellular network (%) in Sweden
Population covered by mobile cellular network is the percentage of people that live in areas served by a mobile cellular signal regardless of whether they use it.This page has the latest values, historical data, forecasts, charts, statistics, an economic calendar and news for Population covered by mobile cellular network (%) in Sweden.
Could These Protocells Tell Us About Earth's Earliest Cells? | Science 2.0
Principles and priorities. Using design principles to embody your… | by Jeremy Keith | Clear Thinking | Medium
Phys.org - biological cells(... continued page 7)
Multiscale modelling for cell motility | Isaac Newton Institute for Mathematical Sciences
Several problems regarding cell motility and morphogenesis are characterized by the contemporary presence of cells that behave as single entities and cells that follow and cluster around them. From the mathematical point of view, describing such phenomena requires the development of mathematical models in which virtual cells can switch from a discrete to a continuous description. Keeping this in mind, the talk aims at presenting some ideas on how to do that, making for instance use of measure theory or introducing the concept of bubble functions ...
Directing Self-propelled Protocells To Deliver Drugs
Directing Self-propelled Protocells To Deliver Drugs
US Patent # 9,860,126. Method and system for coordinating cellular networks operation - Patents.com
The Horiba Xplora: Combining Confocal Microscopy and Raman Chemical Analysis | SelectScience
Watch this video to learn how the XploRA™ from Horiba brings chemical identification directly to your microscope. The XploRA can be coupled to both upright and inverted microscopes, allowing analysis of all sample types, ranging from semiconductors and nano-materials, through to biological cells and tissues.
Scientists Create Possible Precursor to Life - Astrobiology
How did life originate? And can scientists create life? These questions not only occupy the minds of scientists interested in the origin of life, but also researchers working with technology of the future.. If we can create artificial living systems, we may not only understand the origin of life - we can also revolutionize the future of technology.. Protocells are the simplest, most primitive living systems, you can think of. The oldest ancestor of life on Earth was a protocell, and when we see, what it eventually managed to evolve into, we understand why science is so fascinated with protocells. If science can create an artificial protocell, we get a very basic ingredient for creating more advanced artificial life.. However, creating an artificial protocell is far from simple, and so far no one has managed to do that. One of the challenges is to create the information strings that can be inherited by cell offspring, including protocells. Such information strings are like modern DNA or RNA ...
Parameter Estimation in Biological Cell Cycle Models Using Deterministic Optimization
Cell cycle models used in biology can be very complex. These models have parameters with initially unknown values. The values of the parameters vastly aect the accuracy of the models in representing real biological cells. Typically people search for the best parameters to these models using computers only as tools to run simulations. In this thesis methods and results are described for a computer program that searches for parameters to a series of related models using well tested algorithms. The code for this program uses ODRPACK for parameter estimation and LSODAR to solve the dierential equations that comprise the model ...
Index of /Nitrate/009
Parent Directory - childs_01.jpg 18-Nov-2015 13:10 37K childs_02.jpg 18-Nov-2015 13:10 30K childs_03.jpg 18-Nov-2015 13:10 29K childs_04.jpg 18-Nov-2015 13:10 32K childs_alone.html 18-Nov-2015 13:10 18K fullam_01.jpg 18-Nov-2015 13:10 45K fullam_02.jpg 18-Nov-2015 13:10 34K fullam_03.jpg 18-Nov-2015 13:10 19K fullam_straitjackets.., 18-Nov-2015 13:10 18K mairs_01.jpg 18-Nov-2015 13:10 31K mairs_02.jpg 18-Nov-2015 13:10 36K mairs_obit.html 18-Nov-2015 13:10 12K mairs_pullquote1.gif 18-Nov-2015 13:10 1.6K mckenna_01.jpg 18-Nov-2015 13:10 47K mckenna_02.jpg 18-Nov-2015 13:10 57K mckenna_pullquote1.gif 18-Nov-2015 13:10 3.1K mckenna_pullquote2.gif 18-Nov-2015 13:10 2.6K mckenna_trip.html 18-Nov-2015 13:10 19K nugent_01.jpg 18-Nov-2015 13:10 21K nugent_02.jpg 18-Nov-2015 13:11 32K nugent_pullquote1.gif 18-Nov-2015 13:11 4.1K nugent_pullquote2.gif 18-Nov-2015 13:11 5.0K nugent_pullquote3.gif 18-Nov-2015 13:11 2.9K nugent_segal.html 18-Nov-2015 13:11 28K ...
Modelling Lipid Competition Dynamics in Heterogeneous Protocell Populations | IRIS Univ. Bari
Recent experimental work in the field of synthetic protocell biology has shown that prebiotic vesicles are able to steal lipids from each other. This phenomenon is driven purely by asymmetries in the physical state or composition of the vesicle membranes, and, when lipid resource is limited, translates directly into competition amongst the vesicles. Such a scenario is interesting from an origins of life perspective because a rudimentary form of cell-level selection emerges. To sharpen intuition about possible mechanisms underlying this behaviour, experimental work must be complemented with theoretical modelling. The aim of this paper is to provide a coarse-grain mathematical model of protocell lipid competition. Our model is capable of reproducing, often quantitatively, results from core experimental papers that reported distinct types vesicle competition. Additionally, we make some predictions untested in the lab, and develop a general numerical method for quickly solving the equilibrium ...
Brevet US5084394 - Method for corrective calibration of a flow cytometry using a mixture of ... - Google Brevets
The use of a combination of calibrated microbead populations with one or more calibrated biological cell populations to correct calibration of a flow cytometer for size and fluorescence intensity determinations of biological cell samples. The use of calibrated biological cells permits correction for factors related to the instrument and calibration microbeads so long as the excitation and emission spectra of the calibration microbeads, the calibration cells and the cell samples are all the same, respectively.
Caution- Living Systems are Complex Systems
retsch mm400 ball mill specifications
It is also perfectly suitable for the disruption of biological cells as well as for DNA/RNA and protein extraction. With its high performance and great flexibility the mixer mill MM 400 is a unique product in the market. You may also be interested in the High Energy Ball Mill Emax, an entirely new type of mill for high energy input.. read more ...
دانلود کتاب راهنمای الکتروفیزیولوژی کلینیک مایو Mayo Clinic Electrophysiology Manual, 1ed
Cellular Physiology · Part One
lung cancer | Cell Physiology
What hypothesis could you form to explain what would happen to the cell or organism if at least two cell structures were...
WordPress › Profiles » Fábio
Newly formed protocell, artwork - Stock Image G200/0113 - Science Photo Library
Newly formed protocell. Image 2 of 5. Artwork showing cellular components inside a basic cell membrane. This protocell (artificial cell) was formed from a synthetic primeval soup containing PNA (peptide nucleic acid, orange), fatty acids (blue) and lysosomes (enzyme-producing organelles, yellow). The primeval soup was a mix of carbon based molecules that chemically evolved to form simple cells, at the beginning of life. Scientists at Los Alamos National Laboratory in New Mexico, USA, attempted to recreate this in 2006 by making protocells. Here, the loose components have arranged themselves into an ordered structure resembling a simple cell. See G200/112-G200/116 for a series of images showing the creation of a protocell. - Stock Image G200/0113
Separation of non-spherical biological cells with center of gravity offset by a shear flow<...
TY - GEN. T1 - Separation of non-spherical biological cells with center of gravity offset by a shear flow. AU - Mikami, Fumihiko. AU - Tanishita, Kazuo. PY - 1995. Y1 - 1995. N2 - The numerical simulation of cell movement in a shear flow is performed to propose a new cell sorting method using a dumbbell model which describes non-spherical biological cells with center of gravity offset. A dumbbell is found to rotate or glide, depending on the center of gravity offset and the strength of shear flow. In rotating motion, the dumbbell rotates and falls vertically, accompanied by a periodical horizontal drift. In gliding motion, the dumbbell orients and glides in a fluid, where the gliding angle is determined by the center of gravity offset.. AB - The numerical simulation of cell movement in a shear flow is performed to propose a new cell sorting method using a dumbbell model which describes non-spherical biological cells with center of gravity offset. A dumbbell is found to rotate or glide, depending ...
On stochastic simulation of minimal cell models...
If stochastic simulation of minimal cell models intrigues you, see may be interested in: Carletti T, Filisetti A.The stochastic evolution of a protocell: the gillespie algorithm in a dynamically varying volume.Comput Math Methods Med. 2012;2012:423627. Lazzerini-Ospri L, Stano P, Luisi P, Marangoni R.Characterization of the emergent properties of a synthetic quasi-cellular system.BMC Bioinformatics. 2012 Mar 28;13 Suppl 4:S9. Zachar I, Fedor A, Szathmáry E.Two different template replicators coexisting in the same protocell: stochastic simulation of an extended chemoton model.PLoS One. 2011;6(7):e21380. Epub 2011 Jul 19. Van Segbroeck S, Nowé A, Lenaerts T.Stochastic simulation of the chemoton.Artif Life. 2009 Spring;15(2):213-26. | Origin of Life: Emergence, Self-organization and Evolution
Probability Seminar - UW-Math Wiki
Title: Stochastic analysis of biochemical reaction networks with absolute concentration robustness Abstract: It has recently been shown that structural conditions on the reaction network, rather than a fine-tuning of system parameters, often suffice to impart "absolute concentration robustness" on a wide class of biologically relevant, deterministically modeled mass-action systems [Shinar and Feinberg, Science, 2010]. Many biochemical networks, however, operate on a scale insufficient to justify the assumptions of the deterministic mass-action model, which raises the question of whether the long-term dynamics of the systems are being accurately captured when the deterministic model predicts stability. I will discuss recent results that show that fundamentally different conclusions about the long-term behavior of such systems are reached if the systems are instead modeled with stochastic dynamics and a discrete state space. Specifically we characterize a large class of models which exhibit ...
Reviewing the textbook 'Biology: Living Systems' (1994; Glencoe/McGraw-Hill)
Living Systems has seven units -- "The Nature of Biology," "Energy and the Cell," "The Continuation of Life," "Evolutionary Relationships," "Life Functions of Organisms," "Controlling Living Systems" and "Interactions in the Environment." Those are nice titles, but they give only a poor idea of the books content, and they dont convey what the book really is about. At bottom, Living Systems is a book about humans. Indeed, I suspect that it may have originated as an attempt to get some new mileage out of a mass of old material that dealt with human anatomy and physiology. Sure, the book mentions other organisms, and the paste-pushers have thrown in some chapters that purport to tell about evolution and ecology and what-have-you, but the result is silly. The material about evolution and ecology is hopelessly dumb and does little to divert attention from the books anthropocentric stance, and I doubt that anyone who really reads Living Systems will mistake it for a general-biology text. Its ...
A GPS Based Deterministic Channel Allocation for Cellular Network in Mobile Computing: Media & Communications Book Chapter |...
Frontiers | The Construction of Biological 'Inter-Identity' as the Outcome of a Complex Process of Protocell Development in...
The concept of identity is used both (i) to distinguish a system as a particular material entity that is conserved as such in a given environment (token-identity: i.e., identity as permanence or endurance over time), and (ii) to relate a system with other members of a set (type-identity: i.e., identity as an equivalence relationship). Biological systems are characterized, in a minimal and universal sense, by a highly complex and dynamic, far-from-equilibrium organization of very diverse molecular components and transformation processes (i.e., genetically instructed cellular metabolisms) that maintain themselves in constant interaction with their corresponding environments, including other systems of similar nature. More precisely, all living entities depend on a deeply convoluted organization of molecules and processes (a naturalized von Neumann constructor architecture) that subsumes, in the form of current individuals (autonomous cells), a history of ecological and evolutionary interactions (across
Speed to IND for Biologics - Cell Culture Dish - Cell Culture Dish
To achieve ideal timelines, you must accelerate every individual function and handoff utilizing a precise blend of innovative technologies, proven strategies and exceptional project management. The right combination will enable you to successfully go from transfection to IND in less than 12 months. This ambitious goal requires a true team effort from every department.. Speed to IND for Biologics, the first event in CBIs Bioprocessing Series, provides a comprehensive, cross-functional format that brings together experts from every department to share their perspectives, achievements and lessons learned as a community working towards the common goal of accelerating speed while managing and mitigating risk.. With 32 expert presenters, 20 case studies/new data presentations and just two days out of the office, you wont want to miss this first-of-its-kind event!. ...
Cellular Physiology and Biochemistry - Home - Karger Publishers
International Bartlett Lecture Final
Art Piece Uses Industrial Design to Mimic Living System | Blackle Mag
Scientists use nature's design principles to create specialized nanofabrics
NEET (NTA-National Eligibility cum Medical Entrance Test) Biology Cell Structure and Function Questions 299 to 307 -...
Most doctors consider this a normal physiological phenomenon and advise against treatment. This variation of normal anatomy is ... Individual sebaceous cells are large, with central dark nuclei and abundant foamy cytoplasm. The surrounding stroma may contain ... The pathologist must be careful to differentiate such lesions from salivary neoplasms with sebaceous cells, such as sebaceous ... occasional chronic inflammatory cells because of trauma with adjacent teeth. Fordyce spots are completely benign and require no ...
The bottleneck exploits stochastic processes in the cell to increase in the cell-to-cell variability in mutant load as an ... When this occurs, it is known as reaching threshold, and it usually results in physiological consequences. Symptoms of severe ... An example of this phenomenon is Leber optic atrophy. Generally, individuals with this condition do not experience vision ... Many cell divisions and a great deal of time are required for a cell to accumulate enough mutant mitochondria to cause symptoms ...
Flow-enhanced cell adhesion is still an unexplained phenomenon that could result from a transport-dependent increase in on- ... This topic was finally able to be studied thoroughly under physiological shear stress conditions using a typical flow chamber. ... Prabhakarpandian B.; Shen M.C.; Pant K.; Kiani M.F. (2011). "Microfluidic devices for modeling cell-cell and particle-cell ... Since the first experiments, a strange phenomenon was observed. Binding interactions between the white blood cells and the ...
These are cells unspecific resistance modulation and influencing the speed of physiological processes occurring in the cell. ... Because of universality of this phenomenon it was named "the law of intermittent activity of functioning structures" ( ... Regulation of tissue cell mass by the TAS mechanism can be carried out in two physiological regimes - ether by formation of " ... Meanwhile, the cell stress concept considers only the first possibility. At the present moment, two physiological functions of ...
... refers to a phenomenon for which the orientation of cells and stress fibers is influenced by geometrical ... on the surface with nano-micro-groove-like pattern and cell physiological effects". Chinese Science Bulletin. 54 (18): 3200- ... A similar effect can be obtained when cells are cultured on flat surfaces with lines of proteins printed on top (to which cells ... The Interplay Among Cell Traction, Fibrillar Network Deformation, Fibril Alignment, and Cell Contact Guidance". Journal of ...
Otto Frank (physiologist)
He also worked extensively on developing accurate methods to measure blood pressure and other physiological phenomena (e.g. ... J Mol Cell Cardiol. 22 (3): 253-277. doi:10.1016/0022-2828(90)91459-K. PMID 2192068. Norman Sharpe (2006). "Hypertension: from ... This law states that "Within physiological limits, the force of contraction is directly proportional to the initial length of ... J Mol Cell Cardiol 1990; 22: 253-277) Kritik der elastischen Manometer, 1903 Die Registrierung des Pulses durch einen ...
When skin is stretched beyond its physiological limit, mechanotransduction pathways are activated. This leads to cell growth as ... Other biological phenomena such as tissue inflammation can also be considered expansion (see tissue inflammation below). Skin ... Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and ... well as to the formation of new cells. In some cases, this may be accomplished by the implantation of inflatable balloons under ...
Adult stem cell
This phenomenon is referred to as stem cell transdifferentiation or plasticity. It can be induced by modifying the growth ... There is yet no consensus among biologists on the prevalence and physiological and therapeutic relevance of stem cell ... such as mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, etc.). A great deal of adult stem cell ... Pluripotent stem cells, i.e. cells that can give rise to any fetal or adult cell type, can be found in a number of tissues, ...
Nephron remodeling increases the number of distal convoluted cells, principle cells, and intercalated cells. These cells have ... Prolonged usage of loop diuretics will also contributes to resistance through "braking phenomenon". This is the body ... physiological response to reduced extracellular fluid volume, where renin-angiotensin-aldosterone system will be activated ...
Antigen-presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate ... Many other ancient societies have references to this phenomenon, but it was not until the 19th and 20th centuries before the ... Neonates are said to be in a state of physiological immunodeficiency, because both their innate and adaptive immunological ... There is also some evidence that cell surface receptors on B cells and macrophages may detect sex hormones in the system. The ...
They are transmitted, during cell-division, to the daughter-cells: this is the ordinary process of heredity. II. In addition to ... In 1864, Herbert Spencer in his book Principles of Biology, proposed a theory of "physiological units". These hypothetical ... passing of traits and complex developmental phenomena, such as cellular regeneration. "As Darwin explained it, pangenesis was ... which are conducted to the germ-cells and transmit to them those characters which the respective cells may have acquired during ...
Arthur Henfrey (botanist)
In: Botanical and physiological memoirs…, 1853: The phenomenon of rejuvenescence in nature, especially in the life and ... He translated: On Vegetable Cells, by Carl von Nägeli; for the Ray Society, 1846. Chemical Field Lectures, by Julius Adolph ... Outlines of Structural and Physiological Botany, 1847. Reports and Papers on Botany, Ray Society, 1849. The Rudiments of Botany ... Principles of the Anatomy of the Vegetable Cell, by Hugo von Mohl, 1851. ...
Examples of physiological regeneration are the continual replacement of cells of the skin and repair of the endometrium after ... In order to prevent starvation a planarian will use their own cells for energy, this phenomenon is known as de-growth. Limb ... Macrophages are a type of repairing cell that devour dead cells and pathogens, and trigger other immune cells to respond to ... Examples of physiological regeneration in mammals include epithelial renewal (e.g., skin and intestinal tract), red blood cell ...
Breeding for heat stress tolerance
In many species it has been demonstrated that HSPs results in improved physiological phenomena such as photosynthesis, ... Similar analogy in human medical terms is high blood pressure or high body temperature or high white blood cells in body is an ... Evaluating physiological traits to complement empirical selection for wheat in warm environments. Euphytica 100:84-95., Fokar, ... At very high temperatures cause severe cellular injury and cell death may occur within short time, thus leading to a ...
Additional work by the Schwartz group has shown that protective autoimmunity is a naturally occurring physiological phenomenon ... Other cell types, such as B cells and even neural progenitor cells, can promote regulation of immune response in the CNS. Stem ... a population of CNS-resident immune cells, which can act as phagocytes, and antigen-presenting cells. CD4+ T helper cells that ... dictate the profile of the subsequent T cell response. The interaction between the T cells and the microglia/dendritic cells ...
The term osmosis originated in 1827 and its importance to physiological phenomena realized, but it wasn't until 1877, when the ... Heredity information (DNA) is passed on from cell to cell. All cells have the same basic chemical composition. The cell was ... All known living things are made up of one or more cells All living cells arise from pre-existing cells by division. The cell ... All cells arise only from pre-existing cells However, the idea that all cells come from pre-existing cells had in fact already ...
Examples of physiological regeneration are the continual replacement of cells of the skin and repair of the endometrium after ... In order to prevent starvation a planarian will use their own cells for energy, this phenomenon is known as de-growth. ... Macrophages are a type of repairing cell that devour dead cells and pathogens, and trigger other immune cells to respond to ... First, adult cells de-differentiate into progenitor cells which will replace the tissues they are derived from. Second ...
The physiological phenomena of action potentials are possible because voltage-gated ion channels allow the resting potential ... a category of cell include neurons, muscle cells, and endocrine cells, as well as in some plant cells. These action potentials ... Funk, Richard H.W.; Monsees, Thomas K. (2006). "Effects of Electromagnetic Fields on Cells: Physiological and Therapeutical ... Short-lived electrical events called action potentials occur in several types of animal cells which are called excitable cells ...
During stationary growth phase when B. subtilis are at high cell density, approximately 10% of the cells in a population are ... This phenomenon was termed "autoinduction" because it involved a molecule (autoinducer) that accumulated in a growth medium and ... Sporulation, on the other hand, is a physiological response of B. subtilis to depletion of nutrients within a particular ... Dunny, G.M.; Leonard, B.A. (1997). "Cell-cell communication in gram-positive bacteria". Annu. Rev. Microbiol. 51: 527-564. doi: ...
Ishiwata's research interests go beyond the mechanical and physiological import of SPOC to bio-motile systems focusing on the ... It was an important breakthrough regarding a phenomenon that had been "almost completely ignored," he says. ... meiotic spindle and cells (cardiac, HeLa, etc.). He expects that the multiplex network of Chemo-Mechanical Feedback (CMF) loops ...
Stimulation of autophagy in infected cells can help overcome this phenomenon, restoring pathogen degradation. Vesicular ... and that the process was not limited to injury states that functioned under physiological conditions for "reutilization of ... Mol Biol Cell, 17 (2006), 5094-104 Reggiori F, Klionsky DJ (February 2002). "Autophagy in the eukaryotic cell". Eukaryotic Cell ... "Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells". ...
Most cells will exhibit bursting if they are driven by a constant, subthreshold input and particular cells which are ... Physiological models show that for a given input the interspike and interburst timings are much more variable than the timing ... The study of bursting both directly and in how it takes part in other neural phenomena has been very popular since the ... Bursting is a very general phenomenon and is observed in many contexts in many neural systems. For this reason it is difficult ...
Such physiological and cognitive functions are generally not believed to give rise to mental phenomena or qualia, however, as ... "A system that consists of a group of sensory cell types that responds to a specific physical phenomenon, and that corresponds ... plants interpret and respond to these stimuli by a variety of hormonal and cell-to-cell communication pathways that result in ... Nociception (physiological pain) signals nerve-damage or damage to tissue. The three types of pain receptors are cutaneous ( ...
List of MeSH codes
... cell phenomena, and immunity G05 - genetic processes G06 - biochemical phenomena, metabolism, and nutrition G07 - physiological ... chemical and pharmacologic phenomena G13 - genetic phenomena G14 - genetic structures H - Physical Sciences H01 - natural ... cells A12 - fluids and secretions A13 - animal structures A14 - stomatognathic system A15 - hemic and immune systems A16 - ... psychological phenomena and processes F03 - mental disorders F04 - behavioral disciplines and activities G - Biological ...
... referred to as the circadian system that regulate physiological phenomena (hormone levels, metabolic function, body temperature ... There are candidate genes (called clock genes) that exist in most cells in the body and brain, ... Cell. 110 (2): 251-260. ISSN 0092-8674. PMID 12150932. Larsson, Mats; Duffy, David L.; Zhu, Gu; Liu, Jimmy Z.; Macgregor, ... Cell Metabolism. 6 (5): 414-421. doi:10.1016/j.cmet.2007.09.006. ISSN 1550-4131. PMID 17983587. Turek, Fred W.; Joshu, Corinne ...
Among the phenomena he investigated were nerve compression, plasmolysis in cartilage cells, the electrical conductivity of ... he worked at the physiological institute in Bucharest. Călugăreanu founded Știința tuturor ("Science for All") magazine in 1918 ... a professor at Bucharest's higher school of veterinary medicine from 1902 to 1905 and an associate professor of physiological ...
This technique is important to many cell biological and physiological studies during the demonstration of a relationship ... are located in the same area of the cell or very near to one another. The definition can be split into two different phenomena ... coincident detection of zinc accumulation and propidium iodide (a traditional cell death indicator) uptake in multiple cell ... Cell. 148 (4): 635-637. doi:10.1016/j.cell.2012.01.018 - via ScienceDirect. Zinchuk, V; et al. (2013). "Bridging the gap ...
ESA Scientific Research on the International Space Station
Study of the evolution of cardiovascular deconditioning phenomena under weightless conditions (CARDIOSCIENCE) Bone cell ... ESA Physiological parameters that predict orthostatic intolerance after spaceflight (AORTA) - ESA Physiological parameters that ... ESA Cell-Cell Interaction of Monocytes and T-Lymphocytes in microgravity - MIA - ESA IMMUNO - ESA Nerve Growth Factor (NGF) - ... Cell-Cell Interaction of Monocytes and T-Lymphocytes in microgravity - MIA IMMUNO Nerve Growth Factor (NGF) Neuroendocrine and ...
Outer hair cells serve as acoustic amplifiers for stimulation of the inner hair cells. Outer hair cells respond primarily to ... A natural physiological reaction to these threshold shifts is vasoconstriction, which will reduce the amount of blood reaching ... Listener fatigue (also known as listening fatigue or ear fatigue) is a phenomenon that occurs after prolonged exposure to an ... "J. Cell Biol. 164 (6): 887-97. doi:10.1083/jcb.200310055. PMC 2172292. PMID 15024034.. ...
... has been known to stimulate cell growth in normal and cancer cell line cultures, and it was shown that ... With the exception of chemotherapy-induced nausea and vomiting, the patho-physiological basis of many of the disease groups ... "Elevated CSF levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia: new features for ... on cells (including cancer cells) bestowing upon them mobility. and metastasis. It has been suggested that cancer ...
Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells.[ ... the minimum physiological requirement for sodium is 500 milligrams per day. Sodium chloride (also known as common salt) is ... and electron correlative contributing phenomena. While analogous lithium bonds are also known, they are mostly ... The balance between potassium and sodium is maintained by ion transporter proteins in the cell membrane. The cell membrane ...
... only one cell released into the environment could exponentially grow into many thousands of cells over a short amount of time. ... Invasion of long-established ecosystems by organisms from distant bio-regions is a natural phenomenon, which has likely been ... "Pseudo-nitzschia physiological ecology, phylogeny, toxicity, monitoring and impacts on ecosystem health". Harmful Algae. 14: ... For organisms between 10 and 50 microns, such as certain types of phytoplankton, current regulations allow less than 10 cells ...
Theodore Holmes Bullock
This idea, that electrical synapses couple groups of cells into functional units, lead to Bullock's lifelong interest in field ... One colleague described Bullock as an "adventurous scientific explorer, continually seeking undiscovered phenomena and new ... both at the physiological and behavioral level. During this time, the importance of comparative studies also became apparent to ... physiological, and chemical) were relevant to observed differences in species-specific traits, as well as which specific traits ...
Neuroscience of music
The hair cells in the cochlea release neurotransmitter as a result, causing action potentials down the auditory nerve. The ... Johnson, P. B.; Ferraina, S.; Bianchi, L.; Caminiti, R. (1996). "Cortical networks for visual reaching: physiological and ... An example is the phenomenon of tapping to the beat, where the listener anticipates the rhythmic accents in a piece of music. ... however it is often found that cells in primary and non-primary auditory cortex have spatio-temporal receptive fields, rather ...
فهرست یهودیان برنده جایزه نوبل - ویکیپدیا، دانشنامهٔ آزاد
"for their discovery of جی پروتئینs and the role of these proteins in ورارسانی پیام in cells" ... "for his method of reproducing colours photographically based on the phenomenon of interference" ... "for their discoveries concerning the primary physiological and chemical visual processes in the eye" ... "for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell" ...
Brain-derived neurotrophic factor
cell-cell signaling. • positive regulation of brain-derived neurotrophic factor receptor signaling pathway. • collateral ... Heinonen I, Kalliokoski KK, Hannukainen JC, Duncker DJ, Nuutila P, Knuuti J (November 2014). "Organ-specific physiological ... a phenomenon which is partly responsible for exercise-induced neurogenesis and improvements in cognitive function.[ ... regulation of protein localization to cell surface. • regulation of receptor activity. • activation of phospholipase C activity ...
... beginning with cleaning out their own cell after eating through their capped brood cell): feed brood, receive nectar, clean ... Karasov, William H.; Martinez del Rio, Carlos (2008). Physiological Ecology: How Animals Process Energy, Nutrients, and Toxins ... This relationship leads to a phenomenon known as "worker policing". In these rare situations, other worker bees in the hive who ... Eggs are laid singly in a cell in a wax honeycomb, produced and shaped by the worker bees. Using her spermatheca, the queen can ...
List of atheists in science and technology
... of cells in the cell cycle.. *Mark Oliphant (1901-2000): Australian physicist and humanitarian. He played a fundamental ... Several structures and phenomena in anatomy and physiology are named for him, including the Golgi apparatus, the Golgi tendon ... Hermann Joseph Muller (1890-1967): American geneticist and educator, best known for his work on the physiological and genetic ... She is the George Barth Geller Professor of Research in Molecular Biology and Chair of the Department of Cell Biology at Duke ...
எயிட்சு - தமிழ் விக்கிப்பீடியா
2004). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197- ... Planque S, Nishiyama Y, Taguchi H, Salas M, Hanson C, Paul S (June 2008). "Catalytic antibodies to HIV: Physiological role and ... "The Duesberg Phenomenon: A Berkeley virologist and his supporters continue to argue that HIV is not the cause of AIDS. A 3- ... Wood E, Hogg RS, Yip B, Harrigan PR, O'Shaughnessy MV, Montaner JS (2003). "Is there a baseline "சி.டி.4" cell count that ...
The mental entities transcend the physiological just as the physiological transcends the molecular, the molecular, the atomic ... The methodology of science is physicalist, in that inquiry assumes phenomena can be described physically. Segueing to #re_10, ... cells, entire organisms, or minds). These systems are so complex that they can't feasibly be rewritten without tremendous ... it is not even a physiological function of the brain, nor is it a state of the brain at all. (Avenarius 1891, 76). Mach ...
Stimulation of autophagy in infected cells can help overcome this phenomenon, restoring pathogen degradation. ... and that the process was not limited to injury states that functioned under physiological conditions for "reutilization of ... Mechanism of cell death. Cells that undergo an extreme amount of stress experience cell death either through apoptosis or ... "Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells". ...
Neurons are cells specialized for communication. They are able to communicate with neurons and other cell types through ... The morphology, molecular identity, and physiological characteristics of neurons and how they relate to different types of ... Although many studies still hold a reductionist stance looking for the neurobiological basis of cognitive phenomena, recent ... These questions include how signals are processed by neurites - thin extensions from a neuronal cell body, consisting of ...
Endothelium-derived hyperpolarizing factor
... its action is to hyperpolarize vascular smooth muscle cells, causing these cells to relax, thus allowing the blood vessel to ... Although the phenomenon of EDHF has been observed and reported in scientific literature, to date the chemical identity of the ... It implies a reasonable physiological sense, although to some extent and when EDHF acts as backup mechanism for endothelium- ... Cell. Cardiol. 39 (5): 725-32. doi:10.1016/j.yjmcc.2005.07.007. PMID 16122755.. ...
"The discovery of bradykinin has led to a new understanding of many physiological and pathological phenomena including ... Moreover, endothelial cells have been described as a potential source for this B1 receptor-CXCL5 pathway. ... Physiological role (function). Effects. Bradykinin is a potent endothelium-dependent vasodilator, leading to a drop ... Wang G, Sun J, Liu G, Fu Y, Zhang X (December 2017). "Bradykinin Promotes Cell Proliferation, Migration, Invasion, and Tumor ...
This change in the atmosphere increased their effectiveness as nurseries of evolution. While eukaryotes, cells with complex ... Gordon, M.S; Graham, J.B. & Wang, T. (September-October 2004). "Revisiting the Vertebrate Invasion of the Land". Physiological ... However, when confronted with totally unexpected phenomena, such as the first evidence for invisible radiation, experimental ... Multicellular life is composed only of eukaryotic cells, and the earliest evidence for it is the Francevillian Group Fossils ...
"Cell Stem Cell. 10 (5): 515-9. doi:10.1016/j.stem.2012.04.002. PMC 3561899. PMID 22560075.. ... See also: Insulin § Physiological effects. Lowering of the concentration of insulin and substances related to insulin, such as ... Caloric restriction lowers the core body temperature, a phenomenon believed to be an adaptive response to reduce energy ... "Aging Cell. 9 (2): 236-42. doi:10.1111/j.1474-9726.2010.00553.x. PMC 3569090. PMID 20096034.. ...
... originating from the same embryonic cells that produce the limbs, whereas mammalian penises arise from the embryonic cells that ... Consequently, females can store sperm internally for as long as five years, or possibly longer. This phenomenon is ... It is thought that the physiological differences between species prevent hybridization. The genital lock-and-key mechanism can ... Squamate hemipenes also develop from a different cell origin, ... known as cryptic female choice, as the physiological mechanisms ...
Non-invasive intracranial pressure measurement methods
... the inner hair cells of the organ of Corti. The transfer function of this complex mechanical system under physiological ... A measurable acoustic phenomenon that originates in the inner ear would, at least in theory, allow for more precise assessment ... Ragauskas A, Daubaris G, Ragaisis V, Petkus V (October 2003). "Implementation of non-invasive brain physiological monitoring ... and perilymph caused by contractions of the outer hair cells of the inner ear in response to a loud sound, seems to offer such ...
Costa S, Shaw P (March 2007). "'Open minded' cells: how cells can change fate" (PDF). Trends Cell Biol. 17 (3): 101-6. PMID ... Such effects on cellular and physiological phenotypic traits may result from external or environmental factors, or be part of ... Historically, some phenomena not necessarily heritable have also been described as epigenetic. For example, the term epigenetic ... Adult stem cells like bone marrow stem cells have also shown a potential to differentiate into cardiac competent cells when ...
Autoimmune destruction of the adrenal cortex is caused by an immune reaction against the enzyme 21-hydroxylase (a phenomenon ... Eosinophilia and lymphocytosis (increased number of eosinophils or lymphocytes, two types of white blood cells) ... or prednisone tablets in a dosing regimen that mimics the physiological concentrations of cortisol. Alternatively, one-quarter ... seeding of cancer cells from elsewhere in the body, especially lung), hemorrhage (e.g., in Waterhouse-Friderichsen syndrome or ...
The threadlike muscle fibers are the individual muscle cells (myocytes), and each cell is encased within its own endomysium of ... A display of "strength" (e.g. lifting a weight) is a result of three factors that overlap: physiological strength (muscle size ... This phenomenon is called cross education.. Atrophy. Main article: Muscle atrophy ... In one line of thought scientists have believed that muscle cells evolved once and thus all animals with muscles cells have a ...
By contrast, in vivo experiments can provide information about the physiological role of a protein in the context of a cell or ... Lectins typically play a role in biological recognition phenomena involving cells and proteins. Receptors and hormones are ... Other proteins are important in cell signaling, immune responses, cell adhesion, and the cell cycle. In animals, proteins are ... Abundance in cells. It has been estimated that average-sized bacteria contain about 2 million proteins per cell (e.g. E. coli ...
"Phenomena: Not Exactly Rocket Science How Chickens Lost Their Penises (And Ducks Kept Theirs)". Phenomena.nationalgeographic. ... Birds have specialised light-sensing cells deep in their brains[permanent dead link] that respond to light without input from ... Water is needed by many birds although their mode of excretion and lack of sweat glands reduces the physiological demands. ... Birds are tetrachromatic, possessing ultraviolet (UV) sensitive cone cells in the eye as well as green, red and blue ones. ...
... is formed during physiological respiration when oxygen binds to the heme component of the protein hemoglobin in red blood cells ... This phenomenon, where molecule Y affects the binding of molecule X to a transport molecule Z, is called a heterotropic ... Presence in nonerythroid cells. Some nonerythroid cells (i.e., cells other than the red blood cell line) contain ... mesangial cells in the kidney, endometrial cells, cervical cells and vaginal epithelial cells. In these tissues, ...
In contrast, these phenomena are mediated by humoral factors (such as hormones or cytokines) secreted by tumor cells or by an ... The following diseases manifest by means of physiological dysfunction besides the categories above: membranous ... which are cell-cell adhesion molecules found in desmosomes). Underlying cancer or irreversible system impairment, seen in acute ... In this scenario, the body may produce antibodies to fight off the tumor by directly binding and destroying the tumor cell. ...
Phenolic content in wine
This phenomenon is due to a double mutation in the anthocyanin 5-O-glucosyltransferase gene of V. vinifera. In the mid-20th ... This "physiological ripeness", which is roughly determined by tasting the grapes off the vines, is being used along with sugar ... In most grapes anthocyanins are found only in the outer cell layers of the skin, leaving the grape juice inside virtually ... The red wine phenolics piceatannol and myricetin act as agonists for estrogen receptor in human breast cancer cells. M ...
Cell Physiological Phenomena | Open Library
Cell Physiological Phenomena 33 works Search for books with subject Cell Physiological Phenomena. Search. ... Are you sure you want to remove Cell Physiological Phenomena from your list? ... Accessible book, Protected DAISY, Physiology, Cells, Cytology, Methods, Cell physiology, Biological Transport, Biomechanics, ...
January 12, 1884 - Scientific American
Virus Physiological Phenomena | Harvard Catalyst Profiles | Harvard Catalyst
Bio-inspired engineering of cell- and virus-like nanoparticles for drug delivery. Biomaterials. 2017 Dec; 147:155-168. ... "Virus Physiological Phenomena" by people in Harvard Catalyst Profiles by year, and whether "Virus Physiological Phenomena" was ... "Virus Physiological Phenomena" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Virus Physiological Phenomena" by people in Profiles. ...
Measuring the mechanics of morphogenesis
... by molecular and signaling networks ultimately requires the coordinated regulation of mechanical properties in individual cells ... Plant Cells / physiology * Plant Development* * Plant Growth Regulators / physiology* * Plant Physiological Phenomena ... by molecular and signaling networks ultimately requires the coordinated regulation of mechanical properties in individual cells ...
Functional transformation of microbodies in higher plant cells
Plant Physiological Phenomena* * Plants / genetics * Proteins / metabolism * RNA Splicing * RNA, Messenger Substances * ... Functional transformation of microbodies in higher plant cells Cell Struct Funct. 1996 Oct;21(5):387-93. doi: 10.1247/csf. ... 1 Department of Cell Biology, National Institute for Basic Biology, Okazaki, Japan. ...
Bacterial Physiological Phenomena | Harvard Catalyst Profiles | Harvard Catalyst
Single-Cell RNA Sequencing to Understand Host-Pathogen Interactions. ACS Infect Dis. 2019 03 08; 5(3):336-344. ... "Bacterial Physiological Phenomena" by people in Harvard Catalyst Profiles by year, and whether "Bacterial Physiological ... "Bacterial Physiological Phenomena" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ... Below are the most recent publications written about "Bacterial Physiological Phenomena" by people in Profiles. ...
Insect Neurohormones (eBook, 1982) [WorldCat.org]
Proctolin Source Cells --. A.5.2. Myotropic Factors --. A.6. Morphological and Physiological Color Change --. A.6.1. Insect and ... Physiological Color Change --. 6.3. Conclusions --. 7 Behavior and Rhythmic Phenomena --. 7.1. Flight --. 7.2. Circadian ... Proctolin Source Cells -- A.5.2. Myotropic Factors -- A.6. Morphological and Physiological Color Change -- A.6.1. Insect and ... Physiological Color Change -- 6.3. Conclusions -- 7 Behavior and Rhythmic Phenomena -- 7.1. Flight -- 7.2. Circadian Rhythms ...
Axonal guidance defects in a Caenorhabditis elegans mutant reveal cell-extrinsic determinants of neuronal morphology.
Nervous System Physiological Phenomena. Neurons / physiology*, ultrastructure. Phenotype. From MEDLINE®/PubMed®, a database of ... The morphology and positioning of the branch of the posterior lateral microtubule cells (PLMs) were also examined. In wild-type ... The four lateral microtubule cells (LMs), which are probably pioneering neurons, were examined in greatest detail. In the ... 14673646 - The effect of drugs on cell structure of tritrichomonas foetus.. 2610386 - Primary cilia associated with striated ...
Growth Regulation and Carcinogenesis: Volume I - 1st Edition - Walter
... and the role of cell production, cell function, and cell elimination in physiological growth control. ... extrachromosomal phenomena; non-genotoxic carcinogens; immortalization and transformation of cells; ... 1. General Concepts 2. Cell Transformation 3. From Factor Dependence to Factor Independence ...
Leukocyte extravasation - Wikipedia
... a strange phenomenon was observed. Binding interactions between the white blood cells and the vessel walls were observed to ... This topic was finally able to be studied thoroughly under physiological shear stress conditions using a typical flow chamber.[ ... "Microfluidic devices for modeling cell-cell and particle-cell interactions in the microvasculature". Microvascular Research. 82 ... For a catch-bond, the force on the cell pulls the adhesive tip of a fimbria to close tighter on its target cell. As the ...
Effect of undernutrition on the uterine environment during maternal recognition of pregnancy in sheep.
Maternal Nutritional Physiological Phenomena / genetics*. Ovulation. Pregnancy. Pregnancy Outcome. Pregnancy Rate. ... Next Document: Porcine nuclear transfer using somatic donor cells altered to express male germ cell function.. ... Adaptation, Physiological / genetics. Animals. Cyclooxygenase 2 / genetics, metabolism. Dinoprost / metabolism. Dinoprostone / ... Proliferating Cell Nuclear Antigen / genetics, metabolism. RNA, Messenger / metabolism. Receptor, Interferon alpha-beta / ...
Project A3sc - An Atlas of Airways at a Single Cell Level
Circulatory And Respiratory Physiological Phenomena. Functional processes and properties characteristic of the BLOOD; ... More From BioPortfolio on "Project A3sc - An Atlas of Airways at a Single Cell Level". *Related Companies*Related Events* ... The purpose of this research study is to collect cells and liquid from the air passages of healthy adults, both smokers and non ... Project A3sc - An Atlas of Airways at a Single Cell Level. 2018-02-22 19:05:23 , BioPortfolio ...
Bacterial Physiological Phenomena | Profiles RNS
Cell Host Microbe. 2011 Feb 17; 9(2):147-57.. View in: PubMed ... "Bacterial Physiological Phenomena" is a descriptor in the ... "Bacterial Physiological Phenomena" by people in this website by year, and whether "Bacterial Physiological Phenomena" was a ... Below are the most recent publications written about "Bacterial Physiological Phenomena" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Bacterial Physiological Phenomena". ...
Digestive System Physiological Phenomena | Profiles RNS
Mol Cell Biol. 2005 May; 25(10):4189-99.. View in: PubMed ... "Digestive System Physiological Phenomena" is a descriptor in ... "Digestive System Physiological Phenomena" by people in this website by year, and whether "Digestive System Physiological ... Below are the most recent publications written about "Digestive System Physiological Phenomena" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Digestive System Physiological Phenomena". ...
The importance of the observed phenomenon is twofold. On one hand, melatonin has a proposed physiological role in the aging ... Exposure of cells to Aβ(25-35) induced cell death in over two-thirds of the cells by 24 hr (as assessed by the above-mentioned ... Exposure of cells to Aβ(25-35) resulted in marked cell damage characterized by diffuse membrane blebbing (Fig. 3 B), cell ... Control cells exhibited an average intracellular Ca2+/fluo-3 fluorescence of 0.3 ± 0.1 RFI units (n = 20 cells), whereas cells ...
Adult stem cell - Wikipedia
There is yet no consensus among biologists on the prevalence and physiological and therapeutic relevance of stem cell ... This phenomenon is referred to as stem cell transdifferentiation or plasticity. It can be induced by modifying the growth ... Stem cell division and differentiation. A - stem cells; B - progenitor cell; C - differentiated cell; 1 - symmetric stem cell ... Cell Division. To ensure self-renewal, stem cells undergo two types of cell division (see Stem cell division and ...
Haemotaphonomy. The 'strange' world of bloodstains' cells.
Brief overview of research on red blood cell morphology in bloodstains and its application to archaeology, palaeoanthropology, ... Physiological shapes. DISCOCYTES, ECHINOCYTES, SPHEROCYTES, etc.. Biconcave cells, burr cells, spherical cells, etc.. ... But two time-independent RBC shapes are due specifically to blood drying phenomena. So they can be considered as genuine RBC ... burr or berry cells), dacryocytes (tear drop cells), schizocytes (helmet cells), keratocytes (horn cells), drepanocytes (sickle ...
Physiological and biochemical responses to cold and drought in the rock-dwelling pulmonate snail, Chondrina avenacea |...
Ultrastructural and analytical evidence for an unusual cellular phenomenon. Cell Tissue Res 173:417-421PubMedCrossRefGoogle ... Koštál V (2006) Eco-physiological phases of insect diapause. J Insect Physiol 52:113-127PubMedCrossRefGoogle Scholar ... Physiological and biochemical responses to cold and drought in the rock-dwelling pulmonate snail, Chondrina avenacea ... Chown SL, Nicolson SW (2004) Insect physiological ecology. Oxford, New YorkCrossRefGoogle Scholar ...
Program Members | Yale Cancer Center
Cardiovascular Diseases; Cell Membrane Permeability; Circulatory and Respiratory Physiological Phenomena; Neoplasms; Chemicals ... Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Lung Neoplasms; Small Cell Lung Carcinoma ... Carcinoma, Non-Small-Cell Lung; Immunotherapy; Lung; Medical Oncology; Thoracic Neoplasms; Clinical Trial, Phase I; Clinical ... Biochemistry; Biology; Chemistry; Cell Biology; Neoplasms; Pharmacology; Drugs, Investigational; Proteasome Endopeptidase ...
William C. Sessa, PhD > Yale Cancer Center | Yale School of...
Cardiovascular Diseases; Cell Membrane Permeability; Circulatory and Respiratory Physiological Phenomena; Neoplasms; Chemicals ... We discovered that Nogo-B promotes the adhesion of endothelial cells and smooth muscle cells and is a potent chemoattractant ... Siragusa M, Sessa WC: Telmisartan exerts pleiotropic effects in endothelial cells and promotes endothelial cell quiescence and ... 3, miRNA regulation of endothelial cell and smooth muscle cell differentiation;. 4. Proteomic analysis of protein ...
Applications filed at Jun 01 2017 | AUTOMATIC DETECTION OF HUMAN PHYSIOLOGICAL PHENOMENA | Patents.com
METHOD AND SYSTEM OF ENHANCING GANGLION CELL FUNCTION TO IMPROVE PHYSICAL PERFORMANCE. A method and a system of enhancing ... AUTOMATIC DETECTION OF HUMAN PHYSIOLOGICAL PHENOMENA. Introduced here is technology to monitor moisture levels in a hygiene ... SYSTEM AND A METHOD FOR PHYSIOLOGICAL MONITORING. A personal health monitor, including: (a) a physiological data input device ... DEVICE AND SYSTEM FOR PHYSIOLOGICAL MEASUREMENT. A device and a system for physiological measurements are disclosed. The device ...
Ultrafast epithelial contractions provide insights into contraction speed limits and tissue integrity | PNAS
Importantly, under physiological conditions, the cells actively maintain an intermediate size (Fig. 5H). After animals death, ... We hypothesize that T. adhaerens tissue integrity is maintained by activation of the two counteracting cellular phenomena- ... Cell cortex, cell junctions, and associated cell membrane create a stress-bearing continuum, whereas discrete cells are ... softening of the cells can prevent detachment of cell-cell junctions, but expose the tissue to rupture by extreme cell strain. ...
Stability of cytoplasmic nanoviscosity during cell cycle of HeLa cells synchronized with Aphidicolin | Scientific Reports
Our results hint at possible existence of robust mechanism maintaining stable physiological viscosity of the cytoplasm, despite ... In this paper we address this topic by constant observation of nanoviscosity of HeLa cells cytoplasm during S, G2 and G1 phases ... Nanoviscosity is an outcome of variable chemical and structural factors, which can temporarily change with cell-cycle ... Thus, the question arises, whether rates of biochemical reactions depend on the point of cell cycle. ...
Nanophytoplankton - Wikipedia
Circulating MicroRNAs | SpringerLink
... are small non-coding RNAs that regulate various biological phenomena, such as development and homeostasis. The dysregulation of ... cancer cell-cell communication circulating miRNAs exosomes human body fluids miRNAs physiological phenomena purification ... The first section involves the study of secretory miRNAs in cell-cell communication, and the second, the study of circulating ... Methods of Analysis of Dendritic Cell-Derived Exosome-Shuttle MicroRNA and Its Horizontal Propagation Between Dendritic Cells ...
Molecular, Cellular & Physiological Biology | California State University, Northridge
These cells provide progenitor cells for the surrounding meristems. We would like to know if the lines of communication are ... Many human disorders are presumably caused by this phenomenon, including ischemia, Huntingtons disease, and epilepsy. Using a ... Neural crest cells are a stem cell population that migrates from the neural tube early in development. They migrate extensively ... Our goal is to produce genetically engineered plant cells and use these cells as factories for production of biofuel and ...
Online book - Biodiversity Heritage Library
Frontiers | The Dynamics of Plasma Membrane, Metabolism and Respiration (PM-M-R) in Penicillium ochrochloron CBS 123824 in...
This includes the widespread phenomenon of organic acid excretion. One strong hurdle to fully exploit the metabolic capacity of ... In contrast, we do not understand well even basic physiological behavior in these organisms. This includes the widespread ... In contrast, we do not understand well even basic physiological behavior in these organisms. ... phenomenon of organic acid excretion. One strong hurdle to fully exploit the metabolic capacity of these organisms is the ...
Invasion Flashcards by 1 2 | Brainscape
Mesenchymal single cells Mesenchymal chains Clusters/cohorts. Multicellular strands/sheets 3 3. What physiological phenomena ... Genetic alterations lead to hyperproliferation, disassembly of cell-cell contacts, loss of polarity, increased motility and ... What did a comparison of the expression profile of invasive cells vs primary tumours show to be upregulated in invasive cells? ... What are the attachments between the cell and the surface that it is moving along called? ...
THE TANTRIC VISION
The same goes for the molecules, cells, and organs of the human body. Each cell in the body pulsates rhythmically and so do the ... One of the deepest insights of Tantra is that the human body is a single energy phenomenon. At one end of the spectrum, at the ... heart, diaphragm, intestines, lungs, brain, and many other physiological components. The vibrations from these rhythmic ... This orgasm greatly stimulates the brain cells and creates a bridge between the right and left hemispheres, fusing the ...
PhysiologyMechanismsDifferentiationRegulationMolecularExamine anatomical and physiologicalCellularProteinsBiologyPathological phenomenaNormal physiological conditionsBehaviorMetabolismTissuesEndothelialMeSHApoptosisVivoGeneticTissueMoleculesBioelectric phenomenaPlantsDendritic CellsVitroNeoplasmsTumourBiochemicalIntracellularBlood cellsPhysicalMetabolicMechanismSecretionEukaryoticMammalian cellsCancer metastasisMorphologicalAngiogenesisBacterialTumor cellsExtracellularProcesses and propertiesSIGNALSProliferationPharmacologicalOrgansContextStem cellAdhesionSecretoryRegulateOccursMigrationStimuliPathwaysFunctionalHomeostasisWidespreadInsightsDigestive SystemImmune systemRelevanceFetal developmentBiolInteractions
- In 1997, he was recruited to The Ohio State University to help create the Heart and Lung Research Institute where he was deputy director of the institute as well as professor of internal medicine, physiology and cell biology. (hopkinsmedicine.org)
- From the initial attempts at purposeful genetic modification of a cell for the production of valuable compounds, we have now moved on to changing microbes genetically or metabolically.The arsenal of experimental and theoretical tools available for Metabolic and Cellular Engineering has expanded enormously, driven by the re-emergence of Physiology as Systems Biology. (whsmith.co.uk)
- Thus, a gap persists between our understanding of the mechanisms that regulate insulin secretion, mostly derived from in vitro studies, and their relevance to in vivo physiology and β-cell dysfunction of T2D. (diabetesjournals.org)
- Discovery of cytoglobin and its roles in physiology and pathology of hepatic stellate cells. (thefreelibrary.com)
- The finding that the amyloid β protein (Aβ) has neurotoxic properties and that such effects are, in part, mediated by free radicals has provided insights into mechanisms of cell death in AD and an avenue to explore new therapeutic approaches. (jneurosci.org)
- My laboratory is studying the cellular mechanisms responsible for coordinating the migration of these cells. (csun.edu)
- This curriculum will focus on the molecular mechanisms underlying the fundamental processes of the biology of prokaryotic cells and viruses and their interactions with host. (uniroma1.it)
- This curriculum will focus on the molecular mechanisms underlying the fundamental processes of the biology of Eukaryotic cells. (uniroma1.it)
- the molecular mechanisms controlling eukaryotic cell biology during physiological and pathological processes. (uniroma1.it)
- Developmental cell death: morphological diversity and multiple mechanisms. (nih.gov)
- The multiplicity of destructive mechanisms needs to be born in mind in studies of other aspects of cell death such as the signals which trigger it, since different signals probably trigger different types of cell death. (nih.gov)
- To investigate vascular function, Dr. Flavahan's methods range from biochemical or molecular analyses of cellular mediators and cell signaling mechanisms in cultured vascular cells to physiological assessment and fluorescent microscopic imaging of signaling systems in isolated blood vessels. (hopkinsmedicine.org)
- Moreover, immune cells can synthesize and release neurotransmitters themselves, thus using neurotransmitter-mediated pathways via autocrine and paracrine mechanisms. (nature.com)
- To illuminate mechanisms of cell migration within a unified framework, we developed a versatile, computational model for cell migration on 2D substrates. (aps.org)
- These reactions are strictly dependent on chemical exchanges between blood and tissues, by several physiological auto-regulation mechanisms. (epfl.ch)
- T cell tolerance is one of the major mechanisms of tumor escape and one of the major factors limiting the success of cancer vaccines. (jimmunol.org)
- 5 Three major mechanisms control renin release by juxtaglomerular cells: (1) the renal baroreceptor mechanism, whereby renin release is elicited by a decrease in renal perfusion pressure as it occurs during hypotension, shock, hemorrhage, or cardiac failure. (ahajournals.org)
- The chapters provide a timely update on recent advances in this field and comprehensively summarize the current state of knowledge concerning the molecular and physiological mechanisms behind circadian and ultradian oscillations in plants, their physiological implications for growth and development and adaptive responses to a dynamic environment. (nhbs.com)
- Stem cells are key players in at least some of these mechanisms. (stanford.edu)
- In healthy adult organs, robust feedback mechanisms control cell turnover to enforce homeostatic equilibrium between cell division and death [1, (stanford.edu)
- Models of human pattern vision mechanisms are examined in light of new results in psychophysics and single-cell recording. (spie.org)
- In vivo studies have investigated the role of β-cell dysfunction in type 2 diabetes (T2D), whereas in vitro research on islets has elucidated key mechanisms that control the insulin secretion rate. (diabetesjournals.org)
- Furthermore, the mechanisms underpinning β-cell dysfunction in T2D remain undetermined. (diabetesjournals.org)
- The model describes the triggering and amplifying pathways and reproduces a variety of in vitro and in vivo tests in subjects with and without T2D, identifies the mechanisms modulating first-phase insulin secretion rate in response to basal hyperglycemia or insulin resistance, and shows that β-cell dysfunction in T2D can be explained by an impaired amplifying pathway with no need to postulate defects in intracellular calcium handling. (diabetesjournals.org)
- In parallel, in vitro investigation of islets or cells from both animals and humans has formed the basis of our current knowledge of insulin secretory mechanisms ( 2 - 4 ). (diabetesjournals.org)
- We propose a relatively simple model to explain in vitro and in vivo findings with consistent mechanisms and to gain insight into β-cell dysfunction in T2D. (diabetesjournals.org)
- The physiological mechanisms of RNA silencing are only partially understood. (keystonesymposia.org)
- Stem cell division and differentiation. (wikipedia.org)
- To ensure self-renewal, stem cells undergo two types of cell division (see Stem cell division and differentiation diagram). (wikipedia.org)
- NSPCs in the SGZ, which differentiate into granular cells, are anchored within the granular layer of the DG, and following differentiation, establish synaptic connections with neighboring neurons, and maintain the function of the hippocampus. (intechopen.com)
- These cells identified as Gr-1 + CD11b + cells are comprised of precursors of macrophages, granulocytes, DC, and myeloid cells at earlier stages of differentiation (for review, see Refs. (jimmunol.org)
- Biological phenomena, such as cellular differentiation and phagocytosis, are fundamental processes that enable cells to fulfill important physiological roles in multicellular organisms. (sciencemag.org)
- We discuss studies that used these systems in a broad range of cellular and molecular phenomena, including the time-dependent modulation of protein activity in cellular proliferation and differentiation, the reconstitution of phagocytosis, the reconstitution of chemotaxis, and the regulation of actin reorganization. (sciencemag.org)
- The introductory chapters discuss the discovered RNA phages with particular emphasis on the use of specific and transformed cells to study cell formation and differentiation. (worldcat.org)
- However, the control of growth and morphogenesis by molecular and signaling networks ultimately requires the coordinated regulation of mechanical properties in individual cells. (nih.gov)
- The term apoptosis is proposed for a hitherto little recognized mechanism of controlled cell deletion, which appears to play a complementary but opposite role to mitosis in the regulation of animal cell populations. (nih.gov)
- Regulation of vascular reactivity in Scleroderma: new insights into Raynaud's phenomenon. (hopkinsmedicine.org)
- Can we understand the gene regulation phenomena in a cellular/physiological context? (searlescholars.net)
- The key regulated event in this enzymatic cascade is the tightly controlled, minute-to-minute regulation of renin release by the juxtaglomerular cells. (ahajournals.org)
- In this review, we consider and discuss the physiological and pathological roles of CYGB in the regulation of HSC activities in relation to their intracellular [O.sub.homeostasis. (thefreelibrary.com)
- The cortical MT array has been linked to the regulation of cellulose microfibril deposition and, hence, a role in cell expansion, while the pre-prophase band and the phragmoplast have important roles in the positioning and synthesis of the new cell plate in dividing cells. (mcponline.org)
- The molecular and mechanical mechanism of contraction in these nonmuscle cells, as well as their tissue level control ( 5 ⇓ - 7 ), are under intensive investigation ( 5 ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ - 13 ). (pnas.org)
- It is believed that the molecular distinction between symmetric and asymmetric divisions lies in differential segregation of cell membrane proteins (such as receptors ) and their associated proteins between the daughter cells. (wikipedia.org)
- The Molecular, Cellular & Physiological Biology Area is proud of its many lab classes and the connection to biomedical research. (csun.edu)
- Although the factors regulating adhesion and migration have been extensively studied, hyaluronan - a high molecular weight and microns long polysaccharide forming the pericellular matrix around migrating cells, has been mostly neglected. (aps.org)
- Methods of measurement of membrane voltage and membrane currents in isolated cells, recording of random pulse signals from membrane channels on molecular level. (vutbr.cz)
- At the molecular level, little is known about the binding and entry of Chlamydia into the mammalian host cell. (jove.com)
- The W-4PiSMSN incorporates deformable mirrors using two objectives, one above and one below the sample, and uses a set of algorithms to pinpoint molecular positions of proteins deep inside cells, resolving features deep below the surface of the sample. (photonics.com)
- Testmetoder Yta Redovisning av Chemosensory Receptorer i heterologa Cells Sandeepa Dey 1 , Senmiao Zhan 2 , Hiroaki Matsunami 1 1 Department of Molecular Genetics and Molecular Biology , Duke University, 2 Department of Chemistry, Duke University Här visar vi ett protokoll för att utföra levande cell färgning som kan användas för att upptäcka luktreceptorer på ytan av HEK293T celler bekvämt. (jove.com)
- Topics for the Miami Winter Symposia focus on areas of biochemistry in which recent progress offers new insights into the molecular basis of biological phenomena. (worldcat.org)
- This volume summarizes the progress in selected areas of biochemistry and the insights into the molecular basis of biological phenomena. (worldcat.org)
Examine anatomical and physiological2
- We have implemented an unbiased cell morphology-based screen to identify small-molecule modulators of cellular processes using the Cytometrix (TM) automated imaging and analysis system. (biomedsearch.com)
- Here we report the discovery of the fastest epithelial cellular contractions known in any metazoan, to be found in T. adhaerens dorsal epithelium (50% shrinkage of apical cell area within one second, at least an order of magnitude faster than other known examples). (pnas.org)
- IL-1, TNFα and C5a cause the endothelial cells of blood vessels near the site of infection to express cellular adhesion molecules , including selectins . (wikipedia.org)
- The cell cycle is a universal process during which, through a series of cellular events, single cell gives rise to two daughter individuals. (nature.com)
- This communication is mediated by direct cellular contacts (e.g., synapse formation between neurons or between immune cells) and by soluble mediators (neurotransmitters or cytokines). (nature.com)
- Chlamydia Attachment to Mammalian Cells Requires Protein Disulfide Isomerase Cellular Microbiology. (jove.com)
- 1 At the cellular level, the tumor is comprised not only of cancer cells but also a diverse population that includes stromal cells, endothelial cells, components of immune cells, and cancer stem cells (CSCs). (sigmaaldrich.com)
- A novel superresolution nanoscope allows 3D imaging of an entire mammalian cell and its cellular constituents at a resolution that is 20 to 50 times higher than conventional microscopy , with imaging depth improved approximately tenfold over state-of-the-art iPALM and 4Pi-SMSN implementations. (photonics.com)
- One goal is to further push the envelope in the direction of live-cell and tissue imaging, two major roadblocks of modern superresolution techniques, and therefore allow visualization of cellular functions live in their physiological conditions at the nanoscale," said Fang Huang, professor of biomedical engineering at Purdue. (photonics.com)
- This Review will focus on a subset of synthetic biology tools known as bottom-up techniques, which use technologies such as optogenetics and chemically induced dimerization to reconstitute cellular behavior in cells. (sciencemag.org)
- It provides a framework for cell division and the trafficking of organelles and macromolecules, and also serves to regulate important cellular processes such as signaling, translation, and metabolism. (mcponline.org)
- Transmigration of the leukocyte occurs as PECAM proteins, found on the leukocyte and endothelial cell surfaces, interact and effectively pull the cell through the endothelium. (wikipedia.org)
- We have isolated caveolae from endothelial cells in culture and have identified several new proteins. (yale.edu)
- By delivering suppressive cargos consisting of proteins similar to those in parent tumor cells to immune cells, TEX directly or indirectly influence the development, maturation, and antitumor activities of immune cells. (jci.org)
- The most extensively investigated invasion mechanism requires the Type III Secretion System-1 (T3SS-1) encoded by the Salmonella pathogenicity island 1 (SPI-1), a needle-like structure which directly injects bacterial effector proteins into the host cell cytoplasm to manipulate cell signaling pathways leading to actin cytoskeletal rearrangement and bacterial internalization ( Ly and Casanova, 2007 ). (frontiersin.org)
- The ascospores showed differences in the inner cell wall region at the lateral ridge of the spore and also qualitative differences in extractable proteins but did not differ in fatty acid or lipid content. (asm.org)
- We show that the level of expression and the spatial distribution of hyaluronan at the cell-substrate interface, together with the surface density of extracellular matrix proteins, regulate cell adhesion and migration. (aps.org)
- W-4PiSMSN is a versatile and powerful tool that promises a new perspective on how proteins distribute across entire organelles throughout whole cells, an as yet unmet challenge in cell biology. (photonics.com)
- This study, for the first time, has demonstrated that tumor-bearing host-derived ImC, but not their progeny or Gr-1 + cells from control mice, are not only able to migrate into the tumor site and pick up soluble proteins, but also process them and induce Ag-specific tolerance of CD8 + T cells. (jimmunol.org)
- The currently preferred method for producing recombinant proteins from E. coli is to grow the bacteria to high cell density and consequently increase the volumetric productivity [ 1 ]. (pubmedcentralcanada.ca)
- These proteins, often called MT-interacting proteins (MIPs) ( 2 , 4 ), likely bind to MTs as a mechanism to regulate their own activity, to direct their subcellular localization, or as a concentrating mechanism at specific locations within the cell. (mcponline.org)
- The large surface area provided by the MT network, and the cytoskeleton as a whole, likely serves as a matrix for the binding of hundreds of proteins to an extent that is dependent on cell type and environmental conditions ( 6 ). (mcponline.org)
- Miami Winter Symposia, Volume 16: From Gene to Protein: Information Transfer in Normal and Abnormal Cells presents the expression and processing of genetic information at the levels of both proteins and nucleic acids. (worldcat.org)
- Our laboratory is focused on understanding the etiology of vascular dysfunction in these diseases and is focused on several broad aspects of endothelial cell biology and function. (yale.edu)
- A better understanding of adipose stem cell biology and adipogenesis may lead to novel strategies to uncouple obesity from metabolic disease. (jci.org)
- Cell migration is a coordinated process that is ubiquitous in biology and plays a significant role in biological processes, such as morphogenesis, cancer metastasis, and tissue repair. (aps.org)
Normal physiological conditions2
- To begin to understand the mechanism of APP phosphorylation, we studied this process in differentiating neurons under normal physiological conditions. (jneurosci.org)
- CD43, a type I transmembrane protein, is a mucin-like molecule expressed under normal physiological conditions by most hematopoietic cell types. (dissertations.se)
- However, it is known that in vitro cell culture conditions can alter the behavior of cells, proving that a particular subpopulation of cells possesses stem cell properties in vivo is challenging, and so considerable debate exists as to whether some proposed stem cell populations in the adult are indeed stem cells. (wikipedia.org)
- My laboratory investigates the physiological and biochemical effects that neurotransmitters have on the behavior of animals. (csun.edu)
- In contrast, we do not understand well even basic physiological behavior in these organisms. (frontiersin.org)
- We explain contact-inhibition of locomotion in a new way, and show how the collective migration behavior varies with cell density. (aps.org)
- Our goal is to understand how this nutrient-driven mechanism regulates stem cell behavior for lifelong optimization of organ form and function. (stanford.edu)
- Cell Metabolism, 10: 208-218 (2009). (yale.edu)
- Identifying the pathways that lead to APP phosphorylation in vivo , in normal physiological state, could help understand important aspects of APP transport and metabolism. (jneurosci.org)
- The processes underlying the interaction between metabolism and circulation feature a multiscale nature: for instance, although metabolism takes place in cells, it modifies the hemodynamics of peripheral (capillaries) and central (heart) circulation. (epfl.ch)
- The results suggest that E. coli B (BL21) tolerates high glucose concentration not only by its more efficient central carbon metabolism, but also by controlling the glucose transport into the cells regulated by the sRNA SgrS, which may suggest a way to control glucose consumption and increase its efficient utilization. (pubmedcentralcanada.ca)
- According to that conjecture, early animal tissues, lacking rigid unifying cell walls, used contractions to counteract ciliary power and achieve coordinated motility ( 19 ⇓ - 21 ). (pnas.org)
- White blood cells (leukocytes) perform most of their functions in tissues. (wikipedia.org)
- Adult stem cells are undifferentiated cells , found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate damaged tissues . (wikipedia.org)
- The cell cycle allows growth and proliferation of cells, development of tissues and whole organisms. (nature.com)
- In the second stage these apoptotic bodies are shed from epithelial-lined surfaces or are taken up by other cells, where they undergo a series of changes resembling in vitro autolysis within phagosomes, and are rapidly degraded by lysosomal enzymes derived from the ingesting cells.Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development. (nih.gov)
- It is implicated in both physiological involution and atrophy of various tissues and organs. (nih.gov)
- The majority of chemotherapeutic agents used in clinics are highly toxic to both tumor cells and normal tissues due to the lack of specificity. (dovepress.com)
- These ImC accumulate in large numbers in spleens, lymph nodes, and tumor tissues of tumor-bearing mice and are comprised of precursors of myeloid cells. (jimmunol.org)
- We now know that renin cells are precursors that appear early and in multiple tissues during embryonic development. (ahajournals.org)
- The development of genetically encoded probes that allow quantification of ROS (reactive oxygen species) at a cell-specific and subcellular resolution in living tissues, and in real-time, have facilitated a more sophisticated understanding of the role of ROS in signalling and development [ 1 , 2 ]. (portlandpress.com)
- Conclusion: The present review is aimed at providing an update on research and development efforts being made to create effective antiviral chemotherapeutic agents and approaches to their delivery to appropriate targeted cells or tissues. (eurekaselect.com)
- The binding of PSGL-1 on the leukocyte to P-selectin on the endothelial cell allows for the leukocyte to roll along the endothelial surface. (wikipedia.org)
- This is assisted through juxtacrine activation of integrins by chemokines and soluble factors released by endothelial cells. (wikipedia.org)
- In the activated state, integrins bind tightly to complementary receptors expressed on endothelial cells, with high affinity. (wikipedia.org)
- The cytoskeletons of the leukocytes are reorganised in such a way that the leukocytes are spread out over the endothelial cells. (wikipedia.org)
- In this form, leukocytes extend pseudopodia and pass through gaps between endothelial cells. (wikipedia.org)
- Selectins are expressed shortly after cytokine activation of endothelial cells by tissue macrophages. (wikipedia.org)
- Activated endothelial cells initially express P-selectin molecules, but within two hours after activation E-selectin expression is favoured. (wikipedia.org)
- We discovered that Nogo-B promotes the adhesion of endothelial cells and smooth muscle cells and is a potent chemoattractant for endothelial cells. (yale.edu)
- As such, many common diseases such as atherosclerosis, heart disease, cancer, macular degeneration and diabetes have a common signature of endothelial cell dysfunction. (yale.edu)
- In addition, SR-A is found on smooth muscle cells and on a small subpopulation of endothelial cells in the lung ( 8 , 9 ). (jimmunol.org)
- Invasion of non-phagocytic cells (i.e., epithelial, fibroblast and endothelial cells) involves either a trigger or a zipper mechanism mediated by the T3SS-1 or the invasin Rck, respectively. (frontiersin.org)
- Specifically, the regenerative signals originate from the specialized endothelial cells that line the interior of blood vessels in the lung. (bio-medicine.org)
- Dr. Rafii and his researchers had previously uncovered growth factors that control regeneration in the liver and bone marrow, and in both cases, they found that endothelial cells produce the key inductive growth factors, which they defined as "angiocrine factors. (bio-medicine.org)
- The scientists found that removal of the left lung activates receptors on lung endothelial cells that respond to vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF-2). (bio-medicine.org)
- When the investigators disabled receptors of VEGF and FGF-2 specifically in the endothelial cells of the mice, the right lung would not regenerate. (bio-medicine.org)
- E-Selectin, vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) are adhesion molecules participating in mediating interactions between leukocytes and endothelial cells and have been found to be expressed in atherosclerotic plaques. (ahajournals.org)
- In coronary endothelial cells derived from explanted human hearts, angiotensin II (10 −11 to 10 −5 mol/L) induced a concentration-dependent increase in E-selectin expression. (ahajournals.org)
- The effect was measured by cell ELISA and duplex reverse-transcription polymerase chain reaction (RT-PCR) and reached its maximum at 10 −7 mol/L. Angiotensin II induced only a small increase in E-selectin expression in cardiac microvascular endothelial cells. (ahajournals.org)
- In addition, only AT 1 -receptor, but not AT 2 -receptor, mRNA could be detected by RT-PCR in coronary endothelial cells. (ahajournals.org)
- Therefore, it is suggested that AT 1 receptors mediate the effects of angiotensin II on E-selectin expression and leukocyte adhesion on coronary endothelial cells. (ahajournals.org)
- 1 2 The adhesion molecules E-selectin, VCAM-1, and ICAM-1 support monocyte adhesion to and interaction with endothelial cells and, hence, may play a crucial role in the pathogenesis of atherosclerosis. (ahajournals.org)
- VCAM-1 and ICAM-1 have been identified on endothelial cells covering atherosclerotic lesions in human coronary arteries. (ahajournals.org)
- 3 The expression of E-selectin that mediates the adhesion of neutrophils as well as certain T lymphocytes and monocytes is restricted to endothelial cells. (ahajournals.org)
- 10 Specific binding sites for angiotensin II on endothelial cells have been described, 11 and angiotensin II appears to have a modulating effect on several endothelial cell functions, such as prostacyclin, endothelin secretion, 12 13 and endothelial cell growth. (ahajournals.org)
- In view of a possible functional relationship between the renin-angiotensin system and leukocyte adhesion in the pathophysiology of coronary atherosclerosis, the present study was designed to investigate the effects of angiotensin II on the expression and modulation of E-selectin, VCAM-1, and ICAM-1 on human cardiac endothelial cells and on leukocyte adhesion. (ahajournals.org)
- These experiments were performed with endothelial cells from epicardial coronary arteries and from microvessels of human hearts, since previous studies have shown functional differences between these cells in regard to their sensitivity to peptides and their ability to promote leukocyte adhesion. (ahajournals.org)
- Virus Physiological Phenomena" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- Bacterial Physiological Phenomena" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. (nih.gov)
- A comprehensive in vitro and in vivo study using pH-responsive poly(ethylene oxide)-PbAE (PEO-PbAE) copolymer system demonstrated higher apoptosis in MDA-MB-231 breast cancer cells and effectively accumulated into the SKOV3 human ovarian cancer xenograft model. (sigmaaldrich.com)
- Two hallmarks of cancer cells appear to be abnormal electron transport function and free radical leakage from the ETC. The free radical leakage is at levels which cause proliferation rather than apoptosis. (blogspot.com)
- Here we propose a new system for quantitatively evaluating cancer cell invasion in a three-dimensional (3D), in vivo tissue-like environment. (rsc.org)
- ImC are able to take up soluble protein in vivo, process it, and present antigenic epitopes on their surface and induce Ag-specific T cell anergy. (jimmunol.org)
- However, whether ImC are able to take up Ags in vivo, process them, and induce lasting Ag-specific T cell tolerance is unknown. (jimmunol.org)
- However, many compounds identified in screens using cell culture models are often found to be toxic or pharmacologically inactive in vivo 1-2 . (jove.com)
- Impaired insulin secretion from pancreatic β-cells is a long-recognized hallmark of type 2 diabetes (T2D) ( 1 ) and plays a crucial role in the pathogenesis of the disease, as documented in countless in vivo studies. (diabetesjournals.org)
- New knowledge from experimental studies has been incorporated into new models, with a special focus on the role of calcium in exocytosis ( 8 , 9 ), but because the model representation of the glucose-calcium-insulin secretion relationship is often incomplete, only limited extrapolation from in vitro to in vivo findings has been attempted, and β-cell dysfunction in diabetes has been marginally addressed. (diabetesjournals.org)
- Measuring superoxide dynamics in living intact cells, i.e. in vivo , is of particular interest as in most systems superoxide is the precursor for most other ROS and RNS (reactive nitrogen species) such as hydrogen peroxide, the hydroxyl radical or peroxynitrite. (portlandpress.com)
- This phenomenon can be observed as well in vivo as in vitro. (epfl.ch)
- have addressed the physiological and pharmacological relevance of basal receptor activity in vivo. (aspetjournals.org)
- We also show that unique cell and tissue architecture indeed minimizes the load on a contracting cell. (pnas.org)
- Finally, we suggest a physiological role for these contractions: maintaining the integrity of such a minimalistic tissue. (pnas.org)
- Live imaging reveals emergent contractile patterns that are mostly sporadic single-cell events, but also include propagating contraction waves across the tissue. (pnas.org)
- We show that cell contraction speed can be explained by current models of nonmuscle actin-myosin bundles without load, while the tissue architecture and unique mechanical properties are softening the tissue, minimizing the load on a contracting cell. (pnas.org)
- We propose a hypothesis, in which the physiological role of the contraction dynamics is to resist external stresses while avoiding tissue rupture ("active cohesion"), a concept that can be further applied to engineering of active materials. (pnas.org)
- In this histological tissue, three types of cells are present: erythrocytes (red blood cells, RBCs), leukocytes (white blood cells, WBCs) and thrombocytes (platelets, in mammals). (angelfire.com)
- Unlike for embryonic stem cells, the use of human adult stem cells in research and therapy is not considered to be controversial , as they are derived from adult tissue samples rather than human embryos designated for scientific research. (wikipedia.org)
- Under normal conditions, tissue stem cells divide slowly and infrequently. (wikipedia.org)
- Here, we highlight recent human and rodent studies that support the notion that the ability to recruit new fat cells through adipogenesis is a critical determinant of healthy adipose tissue distribution and remodeling in obesity. (jci.org)
- Furthermore, we discuss recent advances in our understanding of the identity of tissue-resident progenitor populations in WAT made possible through single-cell RNA sequencing analysis. (jci.org)
- M2 macrophages moderate the inflammatory response, eliminate cell debris, and promote angiogenesis and tissue remodeling ( 3 , 5 ). (jimmunol.org)
- SR-A is restricted to the myeloid lineage and is expressed on most mature tissue macrophages and on bone marrow-derived dendritic cells and splenic dendritic cells but not on their immature precursor monocytes. (jimmunol.org)
- This work is providing evidence on how the tissue-specific and time-dependent expression of cell surface carbohydrates may be controlled. (go.jp)
- It is interesting to note that Hugo Ribbert (1855-1920), professor of pathology in Bonn, formulated a modified version of Cohnheim's theory considering that sequestration of undifferentiated cells could take place not only during development, but also during the life of the individual because such cells could be generated if a lack of "tissue tension" appears. (hindawi.com)
- On the contrary, if cells are maintained in their normal physiological context within a network of tissue interactions, their proliferation capacity would be counteracted by this tension. (hindawi.com)
- Physical interpretation of electric phenomena in living tissue constitutes a special area of biophysics. (vutbr.cz)
- The subject ‚Bioelectric phenomena' acquaints the students with biophysical basis of the genesis of electric signals on different structural levels , with passive electric properties a of living tissue, and with currently available methods of bioelectric measurements. (vutbr.cz)
- not only can gene expression be manipulated and lineages traced at single-cell and whole-tissue levels, but complete population counts of all cell types are possible. (stanford.edu)
- In 2001, we discovered cytoglobin (CYGB) in hepatic stellate cells (HSC), (1) which are important regulators of tissue repair in the damaged liver. (thefreelibrary.com)
- Regeneration is a process in which tissue parenchymal cells play a major role in reconstructing the lost part of the tissue, resulting in both structural and functional restoration. (thefreelibrary.com)
- Repair is a process in which non-parenchymal connective tissue cells largely contribute to reconstructing the damaged tissue, resulting in structural but not functional restoration. (thefreelibrary.com)
- An unbiased cell morphology-based screen for new, biologically active small molecules. (biomedsearch.com)
- Four human-cancer cell lines and one noncancerous primary cell type were treated with 107 small molecules comprising four different protein kinase-inhibitor scaffolds. (biomedsearch.com)
- What roles do various intracellular molecules have in reducing or exacerbating this phenomenon? (csun.edu)
- Tumor-derived exosomes (TEX) are harbingers of tumor-induced immune suppression: they carry immunosuppressive molecules and factors known to interfere with immune cell functions. (jci.org)
- M1 macrophages classically are activated by IFN-γ, with or without microbial products, produce large amounts of proinflammatory cytokines, express high levels of MHC molecules, and are implicated in the killing of pathogens and tumor cells ( 3 ). (jimmunol.org)
- 1990). When copper availability is adequate to allow the synthesis of the full complement of plastocyanin (~ 8 x 10 6 molecules per cell), the Cyc6 gene encoding cytochrome c 6 is transcriptionally silent (Merchant et al. (searlescholars.net)
- Cancer is a complex disease involving many different cell types, extracellular matrices, immune factors, signaling molecules, and physiological phenomena. (sigmaaldrich.com)
- During the past decade, a set of pathways collectively known as "RNA silencing" has been shown to use small RNA molecules to regulate gene expression and protect cells from pathogens. (keystonesymposia.org)
- Written by a diverse group of leading researchers, Rhythms in Plants will spark the interest of readers from many branches of science: from physicists and chemists wishing to learn about the multi-faceted rhythms in plants, to biologists and ecologists involved in the state-of-the-art modelling of complex rhythmic phenomena. (nhbs.com)
- and just as little, we may expect, will a knowledge of the origin of the existing and extinct species of plants and animals, be the result of physiological and geological investigation. (todayinsci.com)
- These properties can be illustrated with relative ease in vitro , using methods such as clonogenic assays , where the progeny of a single cell is characterized. (wikipedia.org)
- It can be induced by modifying the growth medium when stem cells are cultured in vitro or transplanting them to an organ of the body different from the one they were originally isolated from. (wikipedia.org)
- Finally, treatment of tumor-bearing mice with 4F, a small peptide SR-A ligand able to compete with physiological SR-A ligands in vitro, recapitulates the inhibition of tumor progression and metastasis observed in SR-A −/− mice. (jimmunol.org)
- We then argue that these deformations allow cells to affect each other with novel long-range (in time) interactions and that these may be responsible for patterns observed both in vitro and in tumor samples. (aps.org)
- These cells can suppress T cells in vitro. (jimmunol.org)
- Moreover, in vitro experiments using cells transfected with recombinant MOR indicate that basal activity of the receptor is regulated by morphine pretreatment, resulting in at least two significant changes in receptor and ligand properties. (aspetjournals.org)
- 1. What are the changes that occur in the cells that occur during tumour progression? (brainscape.com)
- 2. What are the different types of tumour cell migration? (brainscape.com)
- 3. What physiological phenomena does tumour migration mimic? (brainscape.com)
- 6. How are tumour cells different in this aspect? (brainscape.com)
- Nanoviscosity of the cytoplasm is a key factor affecting diffusion of biomolecules and - as a consequence - rates of biochemical reactions in a cell. (nature.com)
- Thus, the question arises, whether rates of biochemical reactions depend on the point of cell cycle. (nature.com)
- First, we address the quantitative analysis of the biochemical reactions that are responsible of energy production in muscle cells. (epfl.ch)
- In the Oct. 28 issue of the journal Cell , the research team reports that they have uncovered the biochemical signals in mice that trigger generation of new lung alveoli, the numerous, tiny, grape-like sacs within the lung where oxygen exchange takes place. (bio-medicine.org)
- In this study we demonstrate that melatonin, a pineal hormone with recently established antioxidant properties, is remarkably effective in preventing death of cultured neuroblastoma cells as well as oxidative damage and intracellular Ca 2+ increases induced by a cytotoxic fragment of Aβ. (jneurosci.org)
- The effects of melatonin were extremely reproducible and corroborated by multiple quantitative methods, including cell viability studies by confocal laser microscopy, electron microscopy, and measurements of intracellular calcium levels. (jneurosci.org)
- Nanoviscosity is an outcome of variable chemical and structural factors, which can temporarily change with cell-cycle associated changes of intracellular architecture. (nature.com)
- In mammals, long-term energy storage is achieved through production of intracellular triglycerides, stored within specialized cells called white adipocytes. (jci.org)
- By fusing the kinase with Renilla luciferase and the DARPin to GFP, an energy transfer from luciferase to GFP can be observed in COS-7 cells upon intracellular complex formation. (pnas.org)
- Pubmed ID: 16925789 For Chlamydia, an intracellular pathogen of humans, host cell invasion is obligatory for survival, growth and pathogenesis. (jove.com)
- The arterial diameter oscillations are attributed to the contractile activity of the smooth muscle cells which is directly linked to their intracellular calcium concentration. (epfl.ch)
- These arteries have been observed under confocal fluorescence microscope allowing to quantify the intracellular calcium concentration in smooth muscle cells. (epfl.ch)
- This consideration appeared to be challengeable because, unlike Mb-expressing cells, which are highly contractile (e.g., cardiac and skeletal muscle cells), the hitherto-known functions of HSCs and their activation were not fully discussed from the viewpoint of the intracellular [O.sub.homeostasis of HSCs. (thefreelibrary.com)
- Haemotaphonomy or hemotaphonomy (from the Greek haima for blood, taphos for burial, and nomos for law) is the science that deals with the cytomorphology of the blood cells in bloodstains. (angelfire.com)
- These corpuscles have also been identified in prehistoric immovable items, such as an early Holocene building at ay n Tepesi (Turkey), containing anucleate red blood cells, human immunoglobulin G (IgG) and both human and non-human haemoglobin (Hb) on a stone slab. (angelfire.com)
- For example, the carbohydrate ligand for P-selectin, P-selectin glycoprotein ligand-1 (PSGL-1), is expressed by different types of leukocytes (white blood cells). (wikipedia.org)
- The physiological changes following the reaction of lead upon red blood cells are numerous and show the marked effects of a change in the cell surface. (rupress.org)
- The effects of lead upon red blood cells are thus manifested by shrinkage, inability to expand, increased brittleness, and loss of the normal consistency which makes their surface sticky. (rupress.org)
- Bilirubin comes from red blood cells. (slideshare.net)
- When red blood cells get old, they are destroyed. (slideshare.net)
- Hemoglobin, the iron-containing chemical in red blood cells that carries oxygen, is released from the destroyed red blood cells after the iron it contains is removed. (slideshare.net)
- Conjugated bilirubin is distinguished from the bilirubin that is released from the red blood cells and not yet removed from the blood which is termed unconjugated bilirubin.Jaundice occurs when there is 1) too much bilirubin being produced for the liver to remove from the blood. (slideshare.net)
- Another physiological phenomenon involving cold temperatures, is the effect these temperatures have on hemoglobin in the red blood cells. (bikeforums.net)
- A good physiological experiment like a good physical one requires that it should present anywhere, at any time, under identical conditions, the same certain and unequivocal phenomena that can always be confirmed. (rice.edu)
- Cancer cell proliferation is guided through the micropassage because of the physical restriction imposed by the surrounding solid shell regions. (rsc.org)
- Contractile cells such as fibroblasts exert physical forces on the surrounding extracellular matrix ECM and these forces can lead to material remodeling. (aps.org)
- These physical changes are caused by very small strains (10 −5 ) at ultrasonic frequencies (10 6 Hz), but are closely analogous to those caused by relatively large strains (10 −1 ) at physiological frequencies (10 0 Hz). (rsc.org)
- Prolonged exposure of the brain to higher than physiological levels of insulin may alter metabolic pathways in a manner that is deleterious to cognitive circuitry, given that this circuitry is dependent on cells influenced by these metabolic processes. (diabetesjournals.org)
- Viruses can replicate very fast and may affect any metabolic and physiological function of the host cell. (eurekaselect.com)
- Ultimately, contractile cells replaced ciliary beating as the dominant mechanism for motility in larger animals. (pnas.org)
- Our results hint at possible existence of robust mechanism maintaining stable physiological viscosity of the cytoplasm, despite huge structural changes during cell cycle. (nature.com)
- This is of relevance to the mechanism by which cancer metastasizes cell fate determination in stem cells. (csun.edu)
- However, the mechanism of tumor-associated T cell tolerance remains unresolved. (jimmunol.org)
- However, the exact nature of these cells as well as the mechanism of this phenomenon remains unclear. (jimmunol.org)
- the interactions of host cell with viral, prokaryotic and eukaryotic pathogens. (uniroma1.it)
- To establish an infection, Salmonella has to interact with eukaryotic cells. (frontiersin.org)
- Both are redox-active cofactors found in quantity in electron transfer pathways, such as respiration and photosynthesis, which, in eukaryotic cells, are localized to the mitochondria and chloroplasts. (searlescholars.net)
- The cytoskeleton is the single most important structure that contributes to the highly ordered organization of the eukaryotic cell. (mcponline.org)
- Here we focus on a hydroxyl-substituted analog (hydroxy-PP) of the known Src-family kinase inhibitor PP2 because it induced cell-specific morphological features distinct from all known kinase inhibitors in the collection. (biomedsearch.com)
- We chose N2a cells for most of the experiments because these cells exhibit larger cytoplasmic areas and better attachment to plates than PC12 cells, allowing better morphological analysis of cell damage. (jneurosci.org)
- Its morphological features suggest that it is an active, inherently programmed phenomenon, and it has been shown that it can be initiated or inhibited by a variety of environmental stimuli, both physiological and pathological.The structural changes take place in two discrete stages. (nih.gov)
- This idea was not revolutionary in itself because, as early as 1838, Johannes Müller (1801-1858) had described tumors as the abnormal continuation of embryonic cell development on the basis of morphological similarities. (hindawi.com)
- But Cohnheim went further than the morphological similarities by imagining a common origin of all tumors based on the presence of persistent embryonic cells in the body. (hindawi.com)
- This graph shows the total number of publications written about "Bacterial Physiological Phenomena" by people in Harvard Catalyst Profiles by year, and whether "Bacterial Physiological Phenomena" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Bacterial Physiological Phenomena" by people in Profiles. (harvard.edu)
- Studies of this phenomenon using cultured tumor cells showed that these vesicles were produced in abundance and induced a variety of functional alterations in immune cells. (jci.org)
- Alternatively activated macrophages express the pattern recognition receptor scavenger receptor A (SR-A). We demonstrated previously that coculture of macrophages with tumor cells upregulates macrophage SR-A expression. (jimmunol.org)
- Exosomes, small membrane-bound vesicles, are a class of extracellular vesicles (EVs) made and released by most, if not all, cells. (jci.org)
- This is possible because juxtaglomerular cells are sensors strategically located in the juxtaglomerular apparatus (JGA), where they receive and interpret signals that convey the composition and volume of the extracellular fluid and the level of perfusion pressure. (ahajournals.org)
- This perspective suggests new therapeutical interventions consisting in stabilizing gene expression to control cancer cell proliferation and prevent stochastic gene expression variations that could lead to therapeutic resistance. (hindawi.com)
- Finally Cohnheim additionally mentioned that these embryonic cells can also be the origin of the normal cell proliferation observed in physiological cases during puberty or pregnancy [ 1 ]. (hindawi.com)
- Thus, teratomas became the preferred model for understanding the formation of all tumors (although Virchow considered it an exception [ 1 ]), but also for understanding normal cell proliferation phenomena in adults. (hindawi.com)
- It would trigger the proliferation of these cells in their new environment [ 2 ]. (hindawi.com)
- In this study, p21-ELP-Bac and its control, ELP-p21, were used in cell proliferation studies using the pancreatic cancer cell lines Panc-1, MiaPaca-2, and S2013. (dovepress.com)
- They migrate extensively throughout the embryo and form most of the head and peripheral nervous system, giving rise to sensory and sympathetic ganglia, heart regions, glia, head bones, teeth, muscle cells, sensory organs, melanocytes and other cell types. (csun.edu)
- The immune system and the nervous system are highly complex organs composed of various different cells that must interact with each other for proper function of the system. (nature.com)
- However, they can also diffuse in the blood and bind to nonneuronal cells, or they can be released from efferent nerve endings directly in peripheral organs, such as the spleen, lymph nodes, glands, the intestine, and other organs. (nature.com)
- Ultradian Growth Oscillations in Organs: Physiological Signal or Noise? (nhbs.com)
- Transmission electron micrograph of an adult stem cell displaying typical ultrastructural characteristics. (wikipedia.org)
- Symmetric division gives rise to two identical daughter stem cells, whereas asymmetric division produces one stem cell and one progenitor cell with limited self-renewal potential. (wikipedia.org)
- The niche the stem cell is found in plays a large role in maintaining quiescence. (wikipedia.org)
- Perturbed niches cause the stem cell to begin actively dividing again to replace lost or damaged cells until the niche is restored. (wikipedia.org)
- The ability to regulate the cell cycle in response to external cues helps prevent stem cell exhaustion, or the gradual loss of stem cells following an altered balance between dormant and active states. (wikipedia.org)
- This phenomenon is referred to as stem cell transdifferentiation or plasticity. (wikipedia.org)
- There is yet no consensus among biologists on the prevalence and physiological and therapeutic relevance of stem cell plasticity. (wikipedia.org)
- The elsewhere uncharted security Patricia Neal is been a expression on stem, cell, and aging for romantically sixty others. (smokintex.com)
- Neural crest cells are a stem cell population that migrates from the neural tube early in development. (csun.edu)
- From the mid-19th century when the first theory on the embryonic origin of cancer was formulated to works on embryonal carcinoma cells in the mid-20th century, many steps have been crossed leading to the current cancer stem cell theory postulating that tumor growth is supported by a small fraction of the tumoral cells that have stem-like properties. (hindawi.com)
- However, in the last fifteen years, many works regularly encourage us to revise the concept of cancer stem cell. (hindawi.com)
- In adult flies, the midgut is a stem cell-based organ analogous to the vertebrate small intestine. (stanford.edu)
- Our data suggest that hyaluronan at the cell-substrate interface regulates the adhesion strength by exerting repulsive forces counteracting focal adhesions. (aps.org)
- The invention discloses a cell culture support which provides for the adhesion and culturing of one or more adhesive cells using a photoresist in which to provide a particular patterned design on a surface of the support. (google.com)
- Also a reagent can be added to pretreat the support surface in order to facilitate adhesion at the photoresist prior to applying the photoresist into the cell culture support. (google.com)
- Collagen specifically affects the cell adhesion rate or the morphology of the cells to be adhered to the support. (google.com)
- 3. The cell culture support of claim 1 wherein the cell culture support surface is pretreated with a reagent which facilitates adhesion at the photoresist prior to applying the photoresist into the cell culture support surface. (google.com)
- Well Plate-coupled Microfluidic Devices Designed for Facile Image-based Cell Adhesion and Transmigration Assays Journal of Biomolecular Screening. (jove.com)
- Cancer cells overexpress aberrant forms and amounts of mucins, which contribute to tumor development by regulating cell growth, survival, adhesion, invasion and immune responses. (dissertations.se)
- The degradation occurs when the cells were exposed to the non-metabolizable glucose analog alpha methyl glucoside (αMG) [ 13 ], and also in response to the accumulation of glucose-6-phosphate (G6P) or fructose-6- phosphate in E. coli W3110 as a result of mutations in the glycolytic pathway [ 11 , 12 ]. (pubmedcentralcanada.ca)
- This regenerative phenomenon, however, only occurs after a trauma that abruptly reduces lung mass. (bio-medicine.org)
- In contrast to its motogenic properties in the endothelium, Nogo-B blocks PDGF mediated migration of smooth muscle cells. (yale.edu)
- We show in this study that macrophage SR-A deficiency inhibits tumor cell migration in a coculture assay. (jimmunol.org)
- The presented hydrogel fiber-based migration assays could be useful for studying cell behaviors under 3D coculture conditions and for drug screening and evaluation. (rsc.org)
- During this migration, cells can use different modes of motility. (aps.org)
- Single and collective cell migration are fundamental in development, maintenance and the progression of diseases across multicellular organisms. (aps.org)
- While overexpression of hyaluronan has been shown to promote cell migration and the opposite for low expression levels, our preliminary data suggest a more complex relation. (aps.org)
- We employed the model to recapitulate various aspects of individual and collective cell migration on deformable or stiff substrates. (aps.org)
- and they contain granules from where renin is stored and released in response to a diverse number of stimuli emanating from nearby cells, sympathetic terminal, and from the circulation. (ahajournals.org)
- Active response suppression (inhibition) is seen whenever cortical cells are exposed to grating stimuli that are non-optimal, in either the domain of orientation or spatial frequency. (spie.org)
- As a result, nanoviscosity affects all diffusion-based interactions in living cell, including biosynthesis, signalling pathways or even active transport 5 . (nature.com)
- RNA silencing pathways control an ever-expanding range of biological phenomena, and defects in these pathways lead directly to disease. (keystonesymposia.org)
- Although renin cells are crucial for blood pressure homeostasis, little is known about their nature. (ahajournals.org)
- 8) The discovery of CYGB led us to study its biological and pathophysiological importance in the histological homeostasis of the liver and to rethink the biological features of HSCs as a cell type that harbors [O.sub.bearing globin, especially in relation to their activation upon hepatic insult. (thefreelibrary.com)
- This includes the widespread phenomenon of organic acid excretion. (frontiersin.org)
- Physiological cell death is a widespread phenomenon in the development of both vertebrates and invertebrates. (nih.gov)
- Here, we demonstrate that Drosophila APC-/- tumors trigger widespread Rho expression in non-apoptotic cells, resulting in chronic EGF signaling. (stanford.edu)
- This graph shows the total number of publications written about "Digestive System Physiological Phenomena" by people in this website by year, and whether "Digestive System Physiological Phenomena" was a major or minor topic of these publications. (umassmed.edu)
- Below are the most recent publications written about "Digestive System Physiological Phenomena" by people in Profiles. (umassmed.edu)
- Single-Cell RNA Sequencing to Understand Host-Pathogen Interactions. (harvard.edu)
- The work in my laboratory focuses on the establishment of specific cell fates using genomics to decipher interactions between chromatin and developmental signaling cascades, between genomes and rapidly evolving cell types, and between genomic copy number variation and gene expression. (stanford.edu)
- Conversely the structure of the ECM can determine the form of cell motility and cell-cell interactions. (aps.org)
- Here we present the development of a force measurement method that uses cell-sized, compressible and elastic hydrogel microspheres (with diameters of 5-50 µm) as force sensors, thereby providing a solid cell-gel interface to promote natural cell-like interactions, and allowing measurements of nominal values of the cell-exerted forces, due to their inherent compressibility. (aps.org)