Cellular processes, properties, and characteristics.
Physiological processes and properties of the DENTITION.
Properties and processes of the DIGESTIVE SYSTEM and DENTITION as a whole or of any of its parts.
Physiology of the human and animal body, male or female, in the processes and characteristics of REPRODUCTION and the URINARY TRACT.
Properties, and processes of the MUSCULOSKELETAL SYSTEM and the NERVOUS SYSTEM or their parts.
Functional processes and properties characteristic of the BLOOD; CARDIOVASCULAR SYSTEM; and RESPIRATORY SYSTEM.
The properties and relationships and biological processes that characterize the nature and function of the SKIN and its appendages.
Nutritional physiology related to EXERCISE or ATHLETIC PERFORMANCE.
Physiological processes, factors, properties and characteristics pertaining to REPRODUCTION.
The functions and properties of living organisms, including both the physical and chemical factors and processes, supporting life in single- or multi-cell organisms from their origin through the progression of life.
Nutritional physiology of adults aged 65 years of age and older.
Properties, functions, and processes of the URINARY TRACT as a whole or of any of its parts.
Processes and properties of the MUSCULOSKELETAL SYSTEM.
Biological properties, processes, and activities of VIRUSES.
Properties and processes of the DIGESTIVE SYSTEM as a whole or of any of its parts.
Physiological processes and properties of the BLOOD.
Nutritional physiology of children aged 13-18 years.
Processes and properties of the EYE as a whole or of any of its parts.
Characteristic properties and processes of the NERVOUS SYSTEM as a whole or with reference to the peripheral or the CENTRAL NERVOUS SYSTEM.
Physiological processes and properties of the RESPIRATORY SYSTEM as a whole or of any of its parts.
The functions of the skin in the human and animal body. It includes the pigmentation of the skin.
Nutrition of FEMALE during PREGNANCY.
The physiological processes, properties, and states characteristic of plants.
Physiological processes and properties of BACTERIA.
Processes and properties of the CARDIOVASCULAR SYSTEM as a whole or of any of its parts.
Nutrition of a mother which affects the health of the FETUS and INFANT as well as herself.
Nutritional physiology of children aged 2-12 years.
The processes and properties of living organisms by which they take in and balance the use of nutritive materials for energy, heat production, or building material for the growth, maintenance, or repair of tissues and the nutritive properties of FOOD.
Nutritional physiology of children from birth to 2 years of age.
An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.

E-CELL: software environment for whole-cell simulation. (1/842)

MOTIVATION: Genome sequencing projects and further systematic functional analyses of complete gene sets are producing an unprecedented mass of molecular information for a wide range of model organisms. This provides us with a detailed account of the cell with which we may begin to build models for simulating intracellular molecular processes to predict the dynamic behavior of living cells. Previous work in biochemical and genetic simulation has isolated well-characterized pathways for detailed analysis, but methods for building integrative models of the cell that incorporate gene regulation, metabolism and signaling have not been established. We, therefore, were motivated to develop a software environment for building such integrative models based on gene sets, and running simulations to conduct experiments in silico. RESULTS: E-CELL, a modeling and simulation environment for biochemical and genetic processes, has been developed. The E-CELL system allows a user to define functions of proteins, protein-protein interactions, protein-DNA interactions, regulation of gene expression and other features of cellular metabolism, as a set of reaction rules. E-CELL simulates cell behavior by numerically integrating the differential equations described implicitly in these reaction rules. The user can observe, through a computer display, dynamic changes in concentrations of proteins, protein complexes and other chemical compounds in the cell. Using this software, we constructed a model of a hypothetical cell with only 127 genes sufficient for transcription, translation, energy production and phospholipid synthesis. Most of the genes are taken from Mycoplasma genitalium, the organism having the smallest known chromosome, whose complete 580 kb genome sequence was determined at TIGR in 1995. We discuss future applications of the E-CELL system with special respect to genome engineering. AVAILABILITY: The E-CELL software is available upon request. SUPPLEMENTARY INFORMATION: The complete list of rules of the developed cell model with kinetic parameters can be obtained via our web site at: http://e-cell.org/.  (+info)

Titrating the effects of mitochondrial complex I impairment in the cell physiology. (2/842)

The mitochondrial oxidative phosphorylation system consists of five multimeric enzymes (complexes I-V). NADH dehydrogenase or complex I (CI) is affected in most of the mitochondrial diseases and in some neurodegenerative disorders. We have studied the physiological consequences of a partial CI inhibition at the cellular level. We used a genetic model (40% CI-inhibited human-ape xenomitochondrial cybrids) and a drug-induced model (0-100% CI-inhibited cells using different concentrations of rotenone). We observed a quantitative correlation between the level of CI impairment and cell respiration, cell growth, free radical production, lipid peroxidation, mitochondrial membrane potential, and apoptosis. We showed that cell death was quantitatively associated with free radical production rather than with a decrease in respiratory chain function. The results obtained with human xenomitochondrial cybrid cells were compatible with those observed in rotenone-induced 40% CI-inhibited cells. At high concentrations (5-6-fold higher than the concentration necessary for 100% CI inhibition), rotenone showed a second toxic effect at the level of microtubule assembly, which also led to apoptosis. The correlation found among all the parameters studied helped clarify the physiological consequences of partial CI inhibitions at the cellular level.  (+info)

Workshop conclusions & recommendations.(3/842)

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Time-resolved analysis and visualization of dynamic processes in living cells. (4/842)

Recent development of in vivo microscopy techniques, including green fluorescent proteins, has allowed the visualization of a wide range of dynamic processes in living cells. For quantitative and visual interpretation of such processes, new concepts for time-resolved image analysis and continuous time-space visualization are required. Here, we describe a versatile and fully automated approach consisting of four techniques, namely highly sensitive object detection, fuzzy logic-based dynamic object tracking, computer graphical visualization, and measurement in time-space. Systematic model simulations were performed to evaluate the reliability of the automated object detection and tracking method. To demonstrate potential applications, the method was applied to the analysis of secretory membrane traffic and the functional dynamics of nuclear compartments enriched in pre-mRNA splicing factors.  (+info)

Hyaluronan and proteoglycans in ovarian follicles. (5/842)

Proteoglycans are macromolecules formed by a protein backbone to which one or more glycosaminoglycan side chains are co-valently attached. They can be secreted by the cells, retained at the cell surface, or stored in intracellular vacuoles. Hyaluronan is an extremely long glycosaminoglycan which, at variance with other glycosaminoglycans, is released into the extracellular matrix as a free polysaccharide not co-valently linked to a core protein. Both proteoglycans and hyaluronan influence many aspects of cell behaviour by multiple interactions with other molecules. They are involved in matrix formation, cell-cell and cell-matrix adhesion, cell proliferation and migration, and show co-receptor activity for growth factors. Both proteoglycan and hyaluranon synthesis change significantly during ovarian follicle development and atresia. This review describes the structure of these molecules and their possible function in ovarian physiology.  (+info)

Modeling electroporation in a single cell. I. Effects Of field strength and rest potential. (6/842)

This study develops a model for a single cell electroporated by an external electric field and uses it to investigate the effects of shock strength and rest potential on the transmembrane potential V(m) and pore density N around the cell. As compared to the induced potential predicted by resistive-capacitive theory, the model of electroporation predicts a smaller magnitude of V(m) throughout the cell. Both V(m) and N are symmetric about the equator with the same value at both poles of the cell. Larger shocks do not increase the maximum magnitude of V(m) because more pores form to shunt the excess stimulus current across the membrane. In addition, the value of the rest potential does not affect V(m) around the cell because the electroporation current is several orders of magnitude larger than the ionic current that supports the rest potential. Once the field is removed, the shock-induced V(m) discharges within 2 micros, but the pores persist in the membrane for several seconds. Complete resealing to preshock conditions requires approximately 20 s. These results agree qualitatively and quantitatively with the experimental data reported by Kinosita and coworkers for unfertilized sea urchin eggs exposed to large electric fields.  (+info)

Modeling electroporation in a single cell. II. Effects Of ionic concentrations. (7/842)

This study expands a previously developed model of a single cell electroporated by an external electric field by explicitly accounting for the ionic composition of the electroporation current. The previous model with non-specific electroporation current predicts that both the transmembrane potential V(m) and the pore density N are symmetric about the equator, with the same values at either end of the cell. The new, ion-specific case predicts that V(m) is symmetric and almost identical to the profile from the non-specific case, but N has a profound asymmetry with the pore density at the hyperpolarized end of the cell twice the value at the depolarized end. These modeling results agree with the experimentally observed preferential uptake of marker molecules at the hyperpolarized end of the cell as reported in the literature. This study also investigates the changes in intracellular ionic concentrations induced around an electroporated single cell. For all ion species, the concentrations near the membrane vary significantly, which may explain the electrical disturbances observed experimentally after large electric shocks are delivered to excitable cells and tissues.  (+info)

The osmotic migration of cells in a solute gradient. (8/842)

The effect of a nonuniform solute concentration on the osmotic transport of water through the boundaries of a simple model cell is investigated. A system of two ordinary differential equations is derived for the motion of a single cell in the limit of a fast solute diffusion, and an analytic solution is obtained for one special case. A two-dimensional finite element model has been developed to simulate the more general case (finite diffusion rates, solute gradient induced by a solidification front). It is shown that the cell moves to regions of lower solute concentration due to the uneven flux of water through the cell boundaries. This mechanism has apparently not been discussed previously. The magnitude of this effect is small for red blood cells, the case in which all of the relevant parameters are known. We show, however, that it increases with cell size and membrane permeability, so this effect could be important for larger cells. The finite element model presented should also have other applications in the study of the response of cells to an osmotic stress and for the interaction of cells and solidification fronts. Such investigations are of major relevance for the optimization of cryopreservation processes.  (+info)

Ultra dense networks (UDN) are identified as one of the key enablers for 5G, since they can provide an ultra high spectral reuse factor exploiting proximal transmissions. By densifying the network infrastructure equipment, it is highly possible that each user will have one or more dedicated serving base station antennas, introducing the user-centric virtual cell paradigm. However, due to irregular deployment of a large amount of base station antennas, the interference environment becomes rather complex, thus introducing severe interferences among different virtual cells. This paper focuses on the downlink transmission scheme in UDN where a large number of users and base station antennas is uniformly spread over a certain area. An interference graph is first created based on the large-scale fadings to give a potential description of the interference relationship among the virtual cells. Then, base station antennas and users in the virtual cells within the same maximally-connected component are grouped
The question how living biological cells adapt their local or global mechanical properties when they have to move or deform, is intriguing and a field of intensive study worldwide.
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The aim of CELLmicrocosmos is the interactive 3D stereoscopic visualization of biological cells for a better understanding of their internal structures and their functioning.
The aim of CELLmicrocosmos is the interactive 3D stereoscopic visualization of biological cells for a better understanding of their internal structures and their functioning.
Shop KESS InHouse The Magnolia Trees Outdoor Throw Pillow at Staples. Choose from our wide selection of KESS InHouse The Magnolia Trees Outdoor Throw Pillow and get fast & free shipping on select orders.
Through the Virtual Cell : A Closer Look The processes going on within our virtual cell occur at specific cellular locations. To emphasize the connections between these processes, the Closer Look section has been divided according the cellular organelles associated with the functions being illustrated. To see the Flash movie for the following sequences of images, click here.. ...
Here, we show that the multikinase inhibitor SO alone diminishes pancreatic CSC-like tumor cells, but depletes them significantly only in combination with the phytochemical SF. The major CSC characteristics of the CSChigh MIA-PaCa2 and CSClow BxPc-3 cell lines have been described in our recent study (6). In the present work, we describe the presence of two cell populations, which can be found in CSChigh but not in CSClow cells, namely, spheroidal cells and fibroblast-like adherent cells. These two populations may correspond to primitive CSCs and differentiated daughter cells, suggesting differentiation potential of in vitro cultured pancreatic CSCs. SO targeted both cell subpopulations present in the CSChigh cell line in vitro. This was due to the induction of apoptosis, DNA fragmentation, and downregulation of antiapoptotic proteins. In addition, SO strongly diminished clonogenicity, spheroid formation, and ALDH1 activity. Most importantly, the concentration of 20 μmol/L SO was selectively ...
Genome Project scientists say creating life-saving drugs isnt as easy as knowing all the genes in a human being -- they need a eureka technology to turn a mess into knowledge. Some are yelling Eureka! right now. By Kristen Philipkoski.
Honesty compels me to add that I was a member of the committee that wrote the current (1983) IUPAC-IUB Recommendations on Nomenclature and Symbolism for Amino Acids and Peptides, in which you will find, in Table 1, the words The systematic names and formulas given refer to hypothetical forms in which amino groups are unprotonated and carboxyl groups are undissociated. This convention is useful to avoid various nomenclatural problems but should not be taken to imply that these structures represent an appreciable fraction of the amino-acid molecules. I tried but failed to convince the rest of the committee that hypothetical was a euphemism that should be replaced by fictitious or nonexistent. After more than 30 years its hard to be certain, but I think the second sentence had not originally been in the draft but was added in an effort to keep me quiet. To be fair to the committee, I think the rest of the document shows correct structures, except for lapse with glutathione.. Delete ...
A tandem combinatorial reaction of four acyclic, colorless compounds (two α-aminoketones and two diones; one polar and one nonpolar for each) in aqueous solution (30 mM each, 60 °C, pH 7, 24 h) containing lipid vesicles and with or without quinones and solar illumination affords a distribution of up to 538 p
PDEBUG_CHAN(DFRAME, DEBUG_DEBUG, word %c - %s%s\n, (i & 1) ? b : a, text, (crc_a_ok[i % 5]) ? ok : BAD CRC ...
In this PhD, we present some algorithms and complexity results for two general problems that arise in the analysis of a metabolic network: the search for elementary modes of a network and the search for minimal precursors sets. Elementary modes is a common tool in the study of the cellular characteristic of a metabolic network. An elementary mode can be seen as a minimal set of reactions that can work in steady state independently of the rest of the network. It has therefore served as a mathematical model for the possible metabolic pathways of a cell. Their computation is not trivial and poses computational challenges. We show that some problems, like checking consistency of a network, finding one elementary mode or checking that a set of reactions constitutes a cut are easy problems, giving polynomial algorithms based on LP formulations. We also prove the hardness of central problems like finding a minimum size elementary mode, finding an elementary mode containing two given reactions, counting the
We consider a generic protocell model consisting of any conservative chemical reaction network embedded within a membrane. The membrane results from the self-assembly of a membrane precursor and is se
Ingredients reviewed for EmerginC Protocell Eye Cream to be 91% Top Allergen Free and free of Gluten, Nickel, Preservatives, Lanolin, and MCI/MI
PAOLO FRIL, chairman and chief scientific officer of GeneDupe, based in San Melito, California, is a man with a dream. That dream is a dragon in every home.. GeneDupes business is biotech pets. Not for Dr Fril, though, the mundane cloning of dead moggies and pooches. He plans a range of entirely new animals or, rather, of really quite old animals, with the twist that even when they did exist, it was only in the imagination.. Making a mythical creature real is not easy. But GeneDupes team of biologists and computer scientists reckon they are equal to the task. Their secret is a new field, which they call virtual cell biology . Biology and computing have a lot in common, since both are about processing information in one case electronic; in the other, biochemical. Virtual cell biology aspires to make a software model of a cell that is accurate in every biochemical detail. That is possible because all animal cells use the same parts list mitochondria for energy processing, the endoplasmic ...
Signals and Systems Telecom: Worldwide Cellular Network Operator KPIs of 29 pages is now available with MarketReportsHub.com at starting price of US$ 1000 for a single user PDF. Talk to us for other pricing options.
In this paper we summarize and discuss the modern technology and systems, studied and established by our research group, for performing the detection and special analysis incorporated with the super-h
Study Flashcards On BRS Phys 1 Cell Physiology at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
If it takes up space and has mass then it matters - actually it is matter. There are numerous terms that relate to the basic or fundamental unit of matter - the atom. ELEMENTS are pure substances which means that they consist of only one type of atom. A COMPOUND consists of two or more different kind of atoms or ions in definite proportions ...
Originally published in 1987, the purpose of this title was to develop a conceptual framework for understanding individual humans as complex, functional entitie
Free biology class materials on meiotic cell division, including a lecture PowerPoint, class notes, test questions, study guide & review questions.
Page contains details about transposase oligomers-encapsulated lipid-based nanoparticle-like protocells . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Academics from the University of Newcastle and HMRI have developed a revolutionary online platform to advance cancer research and treatment.
Population covered by mobile cellular network is the percentage of people that live in areas served by a mobile cellular signal regardless of whether they use it.This page has the latest values, historical data, forecasts, charts, statistics, an economic calendar and news for Population covered by mobile cellular network (%) in Sweden.
A team of researchers at Harvard University have modeled in the laboratory a primitive cell, or protocell, that is capable of building, copying and containing DNA.
I think about design principles a lot. Im such a nerd for design principles, I even have a collection. Im not saying all of the design principles in the collection are good - far from it! I collect…
Phys.org internet news portal provides the latest news on science including: Physics, Space Science, Earth Science, Health and Medicine
Several problems regarding cell motility and morphogenesis are characterized by the contemporary presence of cells that behave as single entities and cells that follow and cluster around them. From the mathematical point of view, describing such phenomena requires the development of mathematical models in which virtual cells can switch from a discrete to a continuous description. Keeping this in mind, the talk aims at presenting some ideas on how to do that, making for instance use of measure theory or introducing the concept of bubble functions ...
Technology Networks is an internationally recognised publisher that provides access to the latest scientific news, products, research, videos and posters.
Technology Networks is an internationally recognised publisher that provides access to the latest scientific news, products, research, videos and posters.
Research outputs, collaborations and relationships for Department of Cell Physiology and Metabolism, UNIGE published between 1 December 2019 - 30 November 2020 as tracked by the Nature Index.
A SON element which is operative to carry out at least two different SON functions is provided, wherein each of the SON functions is associated with at least one SON related action, and wherein a SON
Watch this video to learn how the XploRA™ from Horiba brings chemical identification directly to your microscope. The XploRA can be coupled to both upright and inverted microscopes, allowing analysis of all sample types, ranging from semiconductors and nano-materials, through to biological cells and tissues.
How did life originate? And can scientists create life? These questions not only occupy the minds of scientists interested in the origin of life, but also researchers working with technology of the future.. If we can create artificial living systems, we may not only understand the origin of life - we can also revolutionize the future of technology.. Protocells are the simplest, most primitive living systems, you can think of. The oldest ancestor of life on Earth was a protocell, and when we see, what it eventually managed to evolve into, we understand why science is so fascinated with protocells. If science can create an artificial protocell, we get a very basic ingredient for creating more advanced artificial life.. However, creating an artificial protocell is far from simple, and so far no one has managed to do that. One of the challenges is to create the information strings that can be inherited by cell offspring, including protocells. Such information strings are like modern DNA or RNA ...
Cell cycle models used in biology can be very complex. These models have parameters with initially unknown values. The values of the parameters vastly aect the accuracy of the models in representing real biological cells. Typically people search for the best parameters to these models using computers only as tools to run simulations. In this thesis methods and results are described for a computer program that searches for parameters to a series of related models using well tested algorithms. The code for this program uses ODRPACK for parameter estimation and LSODAR to solve the dierential equations that comprise the model ...
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Recent experimental work in the field of synthetic protocell biology has shown that prebiotic vesicles are able to steal lipids from each other. This phenomenon is driven purely by asymmetries in the physical state or composition of the vesicle membranes, and, when lipid resource is limited, translates directly into competition amongst the vesicles. Such a scenario is interesting from an origins of life perspective because a rudimentary form of cell-level selection emerges. To sharpen intuition about possible mechanisms underlying this behaviour, experimental work must be complemented with theoretical modelling. The aim of this paper is to provide a coarse-grain mathematical model of protocell lipid competition. Our model is capable of reproducing, often quantitatively, results from core experimental papers that reported distinct types vesicle competition. Additionally, we make some predictions untested in the lab, and develop a general numerical method for quickly solving the equilibrium ...
The use of a combination of calibrated microbead populations with one or more calibrated biological cell populations to correct calibration of a flow cytometer for size and fluorescence intensity determinations of biological cell samples. The use of calibrated biological cells permits correction for factors related to the instrument and calibration microbeads so long as the excitation and emission spectra of the calibration microbeads, the calibration cells and the cell samples are all the same, respectively.
This article was originally published in UCLA Samueli Newsroom. Researchers at the UCLA Samueli School of Engineering have discovered a new artificial intelligence-based method to discern the properties of live biological cells without destroying them. The advance could enable laboratories to conduct drug-safety screening faster and more efficiently while improving quality control for cell therapies.. The research was published today in Natures Scientific Reports.. We want to know if a batch of live biological cells can be both viable and able to perform the functions we want them to. This noninvasive, AI-backed technique can infer the quality of those cells while keeping the entire batch intact, said study leader Neil Lin, an assistant professor of mechanical and aerospace engineering. We envision this method could be widely adopted by many academic and industrial cell biology labs. And it could be especially important in cell therapies, where the cells themselves are valuable.. Currently, ...
Living systems (humans) are complex. Changing just one thing is not possible. There are always unintended consequences, some perhaps good and other perhaps not so good.
It is also perfectly suitable for the disruption of biological cells as well as for DNA/RNA and protein extraction. With its high performance and great flexibility the mixer mill MM 400 is a unique product in the market. You may also be interested in the High Energy Ball Mill Emax, an entirely new type of mill for high energy input.. read more ...
دانلود کتاب راهنمای الکتروفیزیولوژی کلینیک مایو Mayo Clinic Electrophysiology Manual, 1ed is the first comprehensive guide to the electrical activity of biological cells and tissues and the techniques of elect
Alteration in charge means the membrane acts as a capacitor, with most cells having a resting potential 70-80mV lower than extracellular ...
Kevin G. Phillips, Angela M. Lee, Garth W. Tormoen, Rachel A. Rigg, Anand Kolatkar, Madelyn Luttgen, Kelly Bethel, Lyudmila Bazhenova, Peter Kuhn, Paul Newton, Owen J. T. McCarty ...
Get an answer for What hypothesis could you form to explain what would happen to the cell or organism if at least two cell structures were damaged or destroyed? and find homework help for other Science questions at eNotes
A sub-discipline of biology, its focus is in how organisms, organ systems, organs, cells, and biomolecules carry out the chemical or physical functions that exist in a living system.
O esperado é algo assim? [09-Nov-2017 04:51:35 UTC] hook http_request_args: 1510203095 [09-Nov-2017 04:51:46 UTC] hook… 2 months ago. ...
Newly formed protocell. Image 2 of 5. Artwork showing cellular components inside a basic cell membrane. This protocell (artificial cell) was formed from a synthetic primeval soup containing PNA (peptide nucleic acid, orange), fatty acids (blue) and lysosomes (enzyme-producing organelles, yellow). The primeval soup was a mix of carbon based molecules that chemically evolved to form simple cells, at the beginning of life. Scientists at Los Alamos National Laboratory in New Mexico, USA, attempted to recreate this in 2006 by making protocells. Here, the loose components have arranged themselves into an ordered structure resembling a simple cell. See G200/112-G200/116 for a series of images showing the creation of a protocell. - Stock Image G200/0113
TY - GEN. T1 - Separation of non-spherical biological cells with center of gravity offset by a shear flow. AU - Mikami, Fumihiko. AU - Tanishita, Kazuo. PY - 1995. Y1 - 1995. N2 - The numerical simulation of cell movement in a shear flow is performed to propose a new cell sorting method using a dumbbell model which describes non-spherical biological cells with center of gravity offset. A dumbbell is found to rotate or glide, depending on the center of gravity offset and the strength of shear flow. In rotating motion, the dumbbell rotates and falls vertically, accompanied by a periodical horizontal drift. In gliding motion, the dumbbell orients and glides in a fluid, where the gliding angle is determined by the center of gravity offset.. AB - The numerical simulation of cell movement in a shear flow is performed to propose a new cell sorting method using a dumbbell model which describes non-spherical biological cells with center of gravity offset. A dumbbell is found to rotate or glide, depending ...
If stochastic simulation of minimal cell models intrigues you, see may be interested in: Carletti T, Filisetti A.The stochastic evolution of a protocell: the gillespie algorithm in a dynamically varying volume.Comput Math Methods Med. 2012;2012:423627. Lazzerini-Ospri L, Stano P, Luisi P, Marangoni R.Characterization of the emergent properties of a synthetic quasi-cellular system.BMC Bioinformatics. 2012 Mar 28;13 Suppl 4:S9. Zachar I, Fedor A, Szathmáry E.Two different template replicators coexisting in the same protocell: stochastic simulation of an extended chemoton model.PLoS One. 2011;6(7):e21380. Epub 2011 Jul 19. Van Segbroeck S, Nowé A, Lenaerts T.Stochastic simulation of the chemoton.Artif Life. 2009 Spring;15(2):213-26. | Origin of Life: Emergence, Self-organization and Evolution
Title: Stochastic analysis of biochemical reaction networks with absolute concentration robustness Abstract: It has recently been shown that structural conditions on the reaction network, rather than a fine-tuning of system parameters, often suffice to impart absolute concentration robustness on a wide class of biologically relevant, deterministically modeled mass-action systems [Shinar and Feinberg, Science, 2010]. Many biochemical networks, however, operate on a scale insufficient to justify the assumptions of the deterministic mass-action model, which raises the question of whether the long-term dynamics of the systems are being accurately captured when the deterministic model predicts stability. I will discuss recent results that show that fundamentally different conclusions about the long-term behavior of such systems are reached if the systems are instead modeled with stochastic dynamics and a discrete state space. Specifically we characterize a large class of models which exhibit ...
Artificial cells communicate and cooperate like biological cells, ants (w/ Video): Inspired by the social interactions of ants and slime molds, University of Pittsburgh engineers have designed artificial cells capable of self-organizing into independent groups that can communicate and cooperate. ...
Living Systems has seven units -- The Nature of Biology, Energy and the Cell, The Continuation of Life, Evolutionary Relationships, Life Functions of Organisms, Controlling Living Systems and Interactions in the Environment. Those are nice titles, but they give only a poor idea of the books content, and they dont convey what the book really is about. At bottom, Living Systems is a book about humans. Indeed, I suspect that it may have originated as an attempt to get some new mileage out of a mass of old material that dealt with human anatomy and physiology. Sure, the book mentions other organisms, and the paste-pushers have thrown in some chapters that purport to tell about evolution and ecology and what-have-you, but the result is silly. The material about evolution and ecology is hopelessly dumb and does little to divert attention from the books anthropocentric stance, and I doubt that anyone who really reads Living Systems will mistake it for a general-biology text. Its ...
A GPS Based Deterministic Channel Allocation for Cellular Network in Mobile Computing: 10.4018/978-1-60566-986-1.ch104: The scarcity of the radio channel is the main bottleneck toward maintaining the quality of service (QoS) in a mobile cellular network. As channel allocation
The concept of identity is used both (i) to distinguish a system as a particular material entity that is conserved as such in a given environment (token-identity: i.e., identity as permanence or endurance over time), and (ii) to relate a system with other members of a set (type-identity: i.e., identity as an equivalence relationship). Biological systems are characterized, in a minimal and universal sense, by a highly complex and dynamic, far-from-equilibrium organization of very diverse molecular components and transformation processes (i.e., genetically instructed cellular metabolisms) that maintain themselves in constant interaction with their corresponding environments, including other systems of similar nature. More precisely, all living entities depend on a deeply convoluted organization of molecules and processes (a naturalized von Neumann constructor architecture) that subsumes, in the form of current individuals (autonomous cells), a history of ecological and evolutionary interactions (across
To achieve ideal timelines, you must accelerate every individual function and handoff utilizing a precise blend of innovative technologies, proven strategies and exceptional project management. The right combination will enable you to successfully go from transfection to IND in less than 12 months. This ambitious goal requires a true team effort from every department.. Speed to IND for Biologics, the first event in CBIs Bioprocessing Series, provides a comprehensive, cross-functional format that brings together experts from every department to share their perspectives, achievements and lessons learned as a community working towards the common goal of accelerating speed while managing and mitigating risk.. With 32 expert presenters, 20 case studies/new data presentations and just two days out of the office, you wont want to miss this first-of-its-kind event!. ...
Cellular Physiology and Biochemistry is a multidisciplinary scientific forum dedicated to advancing the frontiers of basic cellular research. It addresses scientists from both the physiological and bi
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Presentation November 2008 on Systems Architecture, the methodological and conceptual background to Living Architecture & Protocell Architecture
Medical researchers might realize a range of breakthroughs if they could look deep inside living biological cells, but existing methods for imaging either
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philipbeesleyarchitect.com A new art installation at Espace EDF Fondation uses biomimetic components made from materials more associated with industrial
In Nature, cells and tissues assemble and organize themselves within a matrix of protein fibers that ultimately determines their structure and function, such as the elasticity of skin and the contractility of heart tissue. ...
Cell Structure and Function: Questions 299-307 of 413. Get to the point NEET (NTA-National Eligibility cum Medical Entrance Test) Biology questions for your exams.
Enzymes are a group of complex proteins or conjugated proteins that are produced by living cells and act as catalysts in specific biochemical reactions.
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DISCOVER | 25 February 2021 | 1.82 GB Loopmasters present the latest addition to the esteemed VIBES series: Ska & Rocksteady! Prepare yourself for
A physiological change in the cells must have occurred to allow this phenomenon. Low salinity is desirable for survival, as ... Also, availability of silicates, a nutrient for the organism, can affect photosynthetic efficiency and cell composition. ...
A new physiological phenomenon of Desired Metaplasia for regeneration of tissues and organs in vivo. Annals of NYAS 1998. Bynum ... 2016 - The first ever artificial pancreas was created 2019 - 3D-print heart from human patient's cells. 2020 - First vaccine ... Matapurkar B G. (1995). US international Patent 6227202 and 20020007223.medical use of Adult Stem cells. ... Adult stem cell use in regeneration of tissues and organs in vivo - B. G Matapurkar U.S . International Patent 1996 - Dolly the ...
This phenomenon is referred to as stem cell transdifferentiation or plasticity. It can be induced by modifying the growth ... There is yet no consensus among biologists on the prevalence and physiological and therapeutic relevance of stem cell ... these cells have the same ability as embryonic stem cells to develop into many different cell types. Olfactory stem cells hold ... such as mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, etc.). A great deal of adult stem cell ...
The bottleneck exploits stochastic processes in the cell to increase in the cell-to-cell variability in mutant load as an ... When this occurs, it is known as reaching threshold, and it usually results in physiological consequences. Symptoms of severe ... An example of this phenomenon is Leber optic atrophy. Generally, individuals with this condition do not experience vision ... Many cell divisions and a great deal of time are required for a cell to accumulate enough mutant mitochondria to cause symptoms ...
Flow-enhanced cell adhesion is still an unexplained phenomenon that could result from a transport-dependent increase in on- ... This topic was finally able to be studied thoroughly under physiological shear stress conditions using a typical flow chamber. ... Prabhakarpandian B, Shen MC, Pant K, Kiani MF (November 2011). "Microfluidic devices for modeling cell-cell and particle-cell ... Since the first experiments, a strange phenomenon was observed. Binding interactions between the white blood cells and the ...
Nephron remodeling increases the number of distal convoluted cells, principle cells, and intercalated cells. These cells have ... Prolonged usage of loop diuretics will also contributes to resistance through "braking phenomenon". This is the body ... physiological response to reduced extracellular fluid volume, where renin-angiotensin-aldosterone system will be activated ... Loop diuretics also inhibits NKCC2 at macula densa, reducing sodium transported into macula densa cells. This stimulates the ...
... refers to a phenomenon for which the orientation of cells and stress fibers is influenced by geometrical ... on the surface with nano-micro-groove-like pattern and cell physiological effects". Chinese Science Bulletin. 54 (18): 3200- ... A similar effect can be obtained when cells are cultured on flat surfaces with lines of proteins printed on top (to which cells ... The Interplay Among Cell Traction, Fibrillar Network Deformation, Fibril Alignment, and Cell Contact Guidance". Journal of ...
When skin is stretched beyond its physiological limit, mechanotransduction pathways are activated. This leads to cell growth as ... Other biological phenomena such as tissue inflammation can also be considered expansion (see tissue inflammation below). Skin ... Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and ... well as to the formation of new cells. In some cases, this may be accomplished by the implantation of inflatable balloons under ...
Part of the sperm's cell membrane then fuses with the egg cell's membrane, and the contents of the head sink into the egg. In ... This is referred to as spontaneous acrosome reaction (SAR). It is now known that in a certain sense, this phenomenon is ... In humans, on the other hand, it remains disputed where exactly the acrosome reaction is initiated in physiological ... It is then expressed as a percentage of the counted cells. For assessment with flow cytometry, the washed cells are incubated ...
These are cells unspecific resistance modulation and influencing the speed of physiological processes occurring in the cell. ... Because of universality of this phenomenon it was named "the law of intermittent activity of functioning structures" ( ... Regulation of tissue cell mass by the TAS mechanism can be carried out in two physiological regimes - ether by formation of " ... Meanwhile, the cell stress concept considers only the first possibility. At the present moment, two physiological functions of ...
Murray, Margaret Ransone (1924). . Phenomena of Secretion in the Amitotic Cells of the Cricket Egg-follicle. Diss. Washington ... Murray, Margaret R. (1928). "The Calcium-Potassium Ratio in Culture Media for Planaria Dorotocephala". Physiological Zoology. 1 ... Their in vitro studies demonstrated that Schwann cells spiraled their surface cell membrane in jelly roll fashion around the ... Her master's thesis work was a study of the secretion of follicular cells of crickets In her thesis, she cites the influence of ...
Antigen-presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate ... Many other ancient societies have references to this phenomenon, but it was not until the 19th and 20th centuries before the ... Neonates are said to be in a state of physiological immunodeficiency, because both their innate and adaptive immunological ... There is also some evidence that cell surface receptors on B cells and macrophages may detect sex hormones in the system. The ...
Most doctors consider this a normal physiological phenomenon and advise against treatment. Fordyce spots are completely benign ... Individual sebaceous cells are large, with central dark nuclei and abundant foamy cytoplasm. Sebaceous glands are normal ... The pathologist must be careful to differentiate such lesions from salivary neoplasms with sebaceous cells, such as sebaceous ...
He also worked extensively on developing accurate methods to measure blood pressure and other physiological phenomena (e.g. ... J Mol Cell Cardiol. 22 (3): 253-277. doi:10.1016/0022-2828(90)91459-K. PMID 2192068. Norman Sharpe (2006). "Hypertension: from ... This law states that "Within physiological limits, the force of contraction is directly proportional to the initial length of ... J Mol Cell Cardiol 1990; 22: 253-277) Kritik der elastischen Manometer, 1903 Die Registrierung des Pulses durch einen ...
... have become iconic medical and physiological textbook images of these phenomena. Another major research interest was the ... His work developed to address the permeation of potassium ions in muscle cells. During a Rockefeller travelling scholarship in ... "An interview with Otto Hutter" (PDF). Physiological Society. Retrieved 29 July 2015.{{cite web}}: CS1 maint: url-status (link) ... Physiological Reports. 5 (6): e13165. doi:10.14814/phy2.13165. ISSN 2051-817X. PMC 5371556. PMID 28320898. The Guardian, ...
In: Botanical and physiological memoirs…, 1853: The phenomenon of rejuvenescence in nature, especially in the life and ... He translated: On Vegetable Cells, by Carl von Nägeli; for the Ray Society, 1846. Chemical Field Lectures, by Julius Adolph ... Outlines of Structural and Physiological Botany, 1847. Reports and Papers on Botany, Ray Society, 1849. The Rudiments of Botany ... Principles of the Anatomy of the Vegetable Cell, by Hugo von Mohl, 1851. ...
Ishiwata's research interests go beyond the mechanical and physiological import of SPOC to bio-motile systems focusing on the ... It was an important breakthrough regarding a phenomenon that had been "almost completely ignored," he says. ... meiotic spindle and cells (cardiac, HeLa, etc.). He expects that the multiplex network of Chemo-Mechanical Feedback (CMF) loops ...
In many species it has been demonstrated that HSPs results in improved physiological phenomena such as photosynthesis, ... Similar analogy in human medical terms is high blood pressure or high body temperature or high white blood cells in body is an ... Evaluating physiological traits to complement empirical selection for wheat in warm environments. Euphytica 100:84-95., Fokar, ... At very high temperatures cause severe cellular injury and cell death may occur within short time, thus leading to a ...
A DamID protocol for single cells has also been developed and applied to human cells. Single cell approaches can highlight the ... The targeted DamID (TaDa) approach uses the phenomenon of ribosome reinitiation to express Dam-fusion proteins at appropriately ... This allows for investigation into developmental or physiological processes in animal models. ... "Genome-wide maps of nuclear lamina interactions in single human cells". Cell. 163 (1): 134-147. doi:10.1016/j.cell.2015.08.040 ...
J Neurol 254(2):257-258 Rüdel, R; Lehmann-Horn, F (1985). "Membrane changes in cells from myotonia patients". Physiological ... Trip J, Faber CG, Ginjaar HB, van Engelen BG, Drost G (2007) Warm-up phenomenon in myotonia associated with the V445M sodium ... When many action potentials are elicited subsequently more K+ is expelled from the cell into the transverse tubular system. As ... Lossin, Christoph (2013). "Nav1.4 slow-inactivation: Is it a player in the warm-up phenomenon of myotonic disorders?". Muscle ...
Most cells will exhibit bursting if they are driven by a constant, subthreshold input and particular cells which are ... Physiological models show that for a given input the interspike and interburst timings are much more variable than the timing ... The study of bursting both directly and in how it takes part in other neural phenomena has been very popular since the ... Bursting is a very general phenomenon and is observed in many contexts in many neural systems. For this reason it is difficult ...
Additional work by the Schwartz group has shown that protective autoimmunity is a naturally occurring physiological phenomenon ... Other cell types, such as B cells and even neural progenitor cells, can promote regulation of immune response in the CNS. Stem ... a population of CNS-resident immune cells, which can act as phagocytes, and antigen-presenting cells. CD4+ T helper cells that ... dictate the profile of the subsequent T cell response. The interaction between the T cells and the microglia/dendritic cells ...
Auxin has a strengthening effect on the elongation growth of the cells. In the case of nutation phenomena, it is possible that ... Consequently, the concave and convex sides show profound physiological differences. The observation that in the hypocotyl the ... they were the first to separate cell walls from the root tip of broad beans. They analysed these cell walls and concluded that ... of protein was found in the cell walls of the plants examined.: 547, 569 Later researchers found protein in the cells but were ...
Such physiological and cognitive functions are generally not believed to give rise to mental phenomena or qualia, however, as ... A transmembrane protein receptor is a protein in the cell membrane that mediates a physiological change in a neuron, most often ... Receptor cells can be classified into types on the basis of three different criteria: cell type, position, and function. ... plants interpret and respond to these stimuli by a variety of hormonal and cell-to-cell communication pathways that result in ...
The term osmosis originated in 1827 and its importance to physiological phenomena realized, but it wasn't until 1877, when the ... Heredity information (DNA) is passed on from cell to cell. All cells have the same basic chemical composition. The cell was ... All known living things are made up of one or more cells All living cells arise from pre-existing cells by division. The cell ... All cells arise only from pre-existing cells However, the idea that all cells come from pre-existing cells had in fact already ...
... a mutation of a gene coding for an ion channel which disrupts electrical phenomenon underlying physiological processes. ... Owing to the presence of cell or debris in the way of the pipette and a target cell the preparation will need to be slightly ... During recording cell viability needs to be maintained as being patch-clamped is stressful for the cell. Negative pressure is ... It is calculated as the sum of the NMS score from all broad cell types that does not match the assigned cell class. Quality ...
The physiological phenomena of action potentials are possible because voltage-gated ion channels allow the resting potential ... a category of cell include neurons, muscle cells, and endocrine cells, as well as in some plant cells. These action potentials ... Funk, Richard HW; Monsees, Thomas K (2006). "Effects of Electromagnetic Fields on Cells: Physiological and Therapeutical ... Short-lived electrical events called action potentials occur in several types of animal cells which are called excitable cells ...
... , (born 1928 in Uttarpara near Calcutta), is a scientist, investigating physiological phenomena in plants and ... Naturforschung 36c,884-887, 1981 Mayee, C.D. & Sarkar, S.: The ultrastructure of Nicotiana tabacum cells infected with potato ... Physiological studies on diploid and polyploid varieties of banana. Science and Culture 16, 215,1950 Sarkar, S.: Versuche zur ... Cellwall-free protoplasts of plant cells (mainly of tobacco and Chinese cabbage) were infected with viruses or with their RNA ...
During stationary growth phase when B. subtilis are at high cell density, approximately 10% of the cells in a population are ... This phenomenon was termed "autoinduction" because it involved a molecule (autoinducer) that accumulated in a growth medium and ... Sporulation, on the other hand, is a physiological response of B. subtilis to depletion of nutrients within a particular ... Dunny, G.M.; Leonard, B.A. (1997). "Cell-cell communication in gram-positive bacteria". Annu. Rev. Microbiol. 51: 527-564. doi: ...
Examples of physiological regeneration are the continual replacement of cells of the skin and repair of the endometrium after ... In order to prevent starvation a planarian will use their own cells for energy, this phenomenon is known as de-growth. Limb ... Second, the blastemal cells will undergo cell proliferation, patterning, cell differentiation and tissue growth using similar ... Macrophages are a type of repairing cell that devour dead cells and pathogens, and trigger other immune cells to respond to ...
J Cell Biol 4:475-478 Hosogi N, Nishioka H, Nakakoshi M (2015) Evaluation of lanthanide salts as alternative stains to uranyl ... This color-change phenomenon is highly prized by collectors.[citation needed] In combination with gold or selenium, red colors ... on Some Physiological Activities in Oilseed Rape during Calcium (Ca2+) Starvation". 10th International Rapeseed Congress. 2: ... and fuel cells. Among these technologies, permanent magnets are often used to fabricate high-efficiency motors, with neodymium- ...
doi:10.1016/j.cell.2016.12.039. PMC 5329766. PMID 28187287. Cooper GM (2000). "The Molecular Composition of Cells". The Cell: A ... Fell DA, Thomas S (October 1995). "Physiological control of metabolic flux: the requirement for multisite modulation". The ... Cellular phenomena Oncometabolism Reactome - Database of biological pathways KEGG - Collection of bioinformatics databases ... Proteins are also important in cell signaling, immune responses, cell adhesion, active transport across membranes, and the cell ...
A similar imprinting phenomenon has also been described in flowering plants (angiosperms). During fertilization of the egg cell ... Tucci V, Isles AR, Kelsey G, Ferguson-Smith AC, Erice Imprinting Group (2019). "Genomic Imprinting and Physiological Processes ... of the parents and are maintained through mitotic cell divisions in the somatic cells of an organism. Appropriate imprinting of ... In germline cells the imprint is erased and then re-established according to the sex of the individual, i.e. in the developing ...
... cells upon cell division, with the mother cell experiencing aging, while the daughter is rejuvenated. There is negligible ... Aging has been defined as "a progressive deterioration of physiological function, an intrinsic age-related process of loss of ... Dańko MJ, Kozłowski J, Schaible R (October 2015). "Unraveling the non-senescence phenomenon in Hydra". Journal of Theoretical ... Cloning from somatic cells rather than germ cells may begin life with a higher initial load of damage. Dolly the sheep died ...
Physiological phenomena whether at the cellular or molecular level in living organisms are driven either directly or indirectly ... Cell fractions representing different parts of the cell (nuclei, mitochondria, lysosomes, peroxisomes, Golgi bodies, cytosol ... Furthermore, zymoblots can be very helpful in cytochemodissection studies aiming at localising enzymes within cells. ... physiological basis for disease resistance, developmental physiology and screening for commercially important enzymes and many ...
To better understand this phenomenon, a study was conducted in Canada after a two-month state of emergency was declared (2020 ... Insulin resistance occurs when cells fail to use insulin efficiently which results in high blood sugar. Furthermore, when ... These all cause stressful times to have many physiological and behavioral impacts on one's diet. Furthermore, sleep deprivation ... Paradoxical insomnia is the phenomenon of a discrepancy between reported sleep duration and objective measurement of sleep. In ...
Outer hair cells serve as acoustic amplifiers for stimulation of the inner hair cells. Outer hair cells respond primarily to ... A natural physiological reaction to these threshold shifts is vasoconstriction, which will reduce the amount of blood reaching ... Common groups at risk of becoming victim to this phenomenon include avid listeners of music and others who listen or work with ... If these cells do not get this chance to recover, they are vulnerable to death. Temporary threshold shifts can result in ...
To address this question, she studied single cells in Cartesian divers and found that rhythms occurred in single cells that ... She continued her research into circadian rhythms for the rest of her career, publishing her monograph Rhythmic Phenomena in ... By bringing dinoflagellates into culture and by defining their multiple photoperiodic responses, especially the physiological ... At that time, biological rhythms were known for a variety of assemblages of cells but Sweeney noted that when such rhythms ...
There he conducted research that would make him the foremost expert on cell makeup of the human eye lens. Alcalá developed ... Bras has specialized in the interpretation of natural phenomena as random functions. He has been recognized for his use of ... The polymides are very strong in terms of their mechanical properties, yet degradable under standard physiological conditions ... Physiology is the study of life, specifically, how cells, tissues, and organisms function. She is a scientist who did her ...
... signaling and cell survival". Cell. 131 (3): 596-610. doi:10.1016/j.cell.2007.08.036. PMID 17981125. S2CID 18885068. Kekuda R, ... A variety of specific physiological functions have been attributed to the σ1 receptor. Chief among these are modulation of Ca2+ ... It has been implicated in several phenomena, including cardiovascular function, schizophrenia, clinical depression, the effects ... doi:10.1016/j.cell.2018.09.048. PMC 6347410. PMID 30633901. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, et al ...
... although the exact mechanisms underlying the phenomenon are not completely understood. It is generally seen in mature cells at ... There have been several studies that suggest the reserve vesicles are seldom ever released in response to physiological stimuli ... Perforant path-granule cells (PP-GC) in the dentate gyrus of the hippocampus in adult rats have been shown to experience ... Because each presynaptic cell can link up to thousands of connections with other neurons, synaptic fatigue and its recovery can ...
A subunits of human factor XIII are made primarily by platelets and other cells of bone marrow origin. B subunits are secreted ... Physiological Reviews. 91 (3): 931-72. doi:10.1152/physrev.00016.2010. PMID 21742792. S2CID 24703788. Laki K, Lóránd L ( ... while a stabilized clot is resistant to this phenomenon. Deficiency of Factor XIII (FXIIID), while generally rare, does occur, ... Dimers containing only A units also occur within cells such as platelets. Large quantities of singular B units (monomers) also ...
This phenomenon has been documented in over sixty plant species spanning a variety of plant types (from herbs and grasses to ... Cell and Environment. 28 (2): 157-166. doi:10.1111/j.1365-3040.2004.01254.x. Oliveira, Rafael S.; Dawson, Todd E.; Burgess, ... there is an ongoing effort to continue the categorization of plants exhibiting this behaviour and adapting this physiological ... The ecological importance of hydraulically redistributed water is becoming better understood as this phenomenon is more ...
PBPK models try to rely a priori on the anatomical and physiological structure of the body, and to a certain extent, on ... is then the limiting factor to distribution in the various cells of the body. That is usually true for small lipophilic drugs. ... and chemical descriptions of the phenomena involved in the complex ADME processes. A large degree of residual simplification ... They are also parallel to physiome models, but do not aim at modelling physiological functions beyond fluid circulation in ...
... and decode information about the relative locations and attributes of phenomena in their spatial environment. Place cells work ... Although the details of the Hassenstein-Reichardt model have not been confirmed at an anatomical and physiological level, the ... ganglion cells receive inputs from bipolar cells and starburst amacrine cells. The DS ganglion cells respond to their preferred ... There are three known types of DS cells in the vertebrate retina of the mouse, ON/OFF DS ganglion cells, ON DS ganglion cells, ...
Mobley H (13 March 2006). "How do antibiotics kill bacterial cells but not human cells?". Scientific American. 294 (6): 98. ... Physiological enzyme inhibition can also be produced by specific protein inhibitors. This mechanism occurs in the pancreas, ... Enzyme inactivation is generally explained as a chemical process involving several phenomena like aggregation, dissociation ... This causes the cell wall to lose strength and the bacteria to burst. In the figure, a molecule of penicillin (shown in a ball- ...
... wider filaments instead are disk-shaped with cell lengths from 0.10 to 0.90 times their cell width. In all of the cultured ... 2016-08-10). "Physiological and Metagenomic Analyses of Microbial Mats Involved in Self-Purification of Mine Waters ... causing the phenomenon called "bulking". Beggiatoa are also able to detoxify hydrogen sulfide in soil and have a role in the ... Species of Beggiatoa have cells up to 200 µm in diameter and they are one of the largest prokaryotes on Earth. The genera ...
"Endonuclease G promotes cell death of non-invasive human breast cancer cells". Experimental Cell Research. 312 (20): 4139-49. ... Kerr JF, Wyllie AH, Currie AR (Aug 1972). "Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue ... Apoptosis occurs in many physiological and pathological processes. It plays an important role during embryonal development as ... In epithelial cells, the nuclear localization and proapoptotic function of EndoG leads it to play a role in cell senescence. In ...
Cell. 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923. Imai Y ... Kerr JF, Wyllie AH, Currie AR (Aug 1972). "Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue ... Apoptosis occurs in many physiological and pathological processes. It plays an important role during embryonal development as ... an apoptotic cell undergoes structural changes including cell shrinkage, plasma membrane blebbing, nuclear condensation, and ...
Thus, each cell of the matrix corresponds to the strength of the association between the row item and the column item. Learning ... There are still a number of memory phenomena for which TLC has no account, including why people are able to respond quickly to ... This strongly suggests that encoding of information leading to semantic memory does not have its physiological basis in the ... Each cell in the matrix is then transformed according to the equation: M t , d ′ = ln ⁡ ( 1 + M t , d ) − ∑ i = 0 D P ( i , t ...
The anatomical and physiological basis of human speech production: adaptations and exaptations. In M. Tallerman and K. .Gibson ... Onomatopoeia can explain the first couple of words all derived from natural phenomenon, but there is no explanation as to how ... even if its letters are invisible and its words are buried in the cells of our bodies." - Beadle, G.; Beadle, M. (1966). The ... The origin of speech refers to the general problem of the origin of language in the context of the physiological development of ...
This phenomenon allows neighboring cells adjacent to the apoptotic cell sending out the find me signal to be engulfed without ... Schetinger, Morsch, Bonan, Wyse (2008). "NTPDase and 5'-nucleotidase activities in physiological and disease conditions: New ... Identified in breast cancer cells, this find-me signals is released by MCF-7 cells to attract the THP-1 monocytes. Other cells ... This has been observed in Jurkat cells (primary thymocytes), MCF-7 cells, and lung epithelial cells. Release is dependent upon ...
For example, a hot particle embedded in an organ (such as lung) results in a very high dose in the cells directly adjacent to ... In very high dose radiation therapy, it was known at the time that radiation can cause a physiological increase in the rate of ... a dose-response phenomenon characterized by low-dose stimulation and high-dose inhibition. Calabrese EJ (October 2015). "On the ... January 2012). "Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells". Proceedings of the ...
This means that in progenesis, germ cell growth is accelerated relative to normal or in neoteny; while somatic cell growth is ... These factors are part of a complex phenomenon termed Island syndrome or Foster's rule. The mole salamander, a close relative ... Spicer, J. I.; Burggren, W. W. (2003). "Development of physiological regulatory systems: altering the timing of crucial events ... Cell. 134 (1): 25-36. doi:10.1016/j.cell.2008.06.030. PMID 18614008. Held, Lewis I. (2014). How the Snake Lost its Legs. ...
This lesion can be due to an ischemic cell death after an acute posterior cerebral infarction. The most prevalent research on ... Thus, when a patient reaches for an enlarged object, he or she is overcoming that physiological contraction. However, this ... The differences in visual phenomena, such as macropsia with slow motion versus macropsia without slow motion, may result from ... In the case of macropsia, the greater density of photoreceptor cells leads to greater stimulation making the object seem larger ...
Because the protein is large, it has a low leakage rate from cells compared to lipophilic dyes such as DiI. It lacks phenomena ... the first experiments involving the injection of the protein into the tissues of living animals to visualize the physiological ... and cultured cells. Cultured cells expressing the aequorin gene can effectively synthesize apoaequorin; however, recombinant ... Therefore it is necessary to add coelenterazine into the culture medium of the cells to obtain a functional protein and thus ...
Hardy WB (May 1899). "On the structure of cell protoplasm: Part I. The Structure produced in a Cell by Fixative and Post-mortem ... Thomson JA, Schurtenberger P, Thurston GM, Benedek GB (October 1987). "Binary liquid phase separation and critical phenomena in ... of the first discovered examples of a highly dynamic intracellular liquid biomolecular condensate with a clear physiological ... June 2018). "Protein Phase Separation: A New Phase in Cell Biology". Trends in Cell Biology. 28 (6): 420-435. doi:10.1016/j.tcb ...
These properties of free heme can sensitize a variety of cell types to undergo programmed cell death in response to pro- ... This phenomenon, which states that hemoglobin's oxygen binding affinity is inversely proportional to both acidity and ... However, due to its toxic properties, proteins such as Hemopexin (Hx) are required to help maintain physiological stores of ... Briefly, when cells are exposed to free radicals, there is a rapid induction of the expression of the stress-responsive heme ...
These germination tubes will pierce host cell walls to initiate infection, or if wounds are present the pathogen may enter in ... a phenomenon that is sometimes mistaken for frost damage. The symptoms of this disease are also commonly confused with ... Physiological Plant Pathology. 19 (1): 7-IN9. doi:10.1016/s0048-4059(81)80003-3. Index Fungorum USDA ARS Fungal Database (CS1 ... Zinniol is highly hydrophobic, and has been detected inside cell walls after infection occurs, so it is assumed that the toxin ...
... and applications of these systems and their capacity for in vivo analysis and optical imaging at the single-cell level are ... Cell Culture Techniques / instrumentation* * Cell Culture Techniques / methods * Cell Physiological Phenomena* * Equipment ... Nanoprobes and nanobiosensors for monitoring and imaging individual living cells Nanomedicine. 2006 Mar;2(1):22-30. doi: ... These devices have the capacity to sense individual chemical species in specific locations within a cell. This article ...
Guideline: optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube ... Browsing by Subject "Maternal Nutritional Physiological Phenomena". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. ...
Cell Physiological Phenomena [G04]. *Membrane Potentials [G04.580]. *Membrane Potential, Mitochondrial [G04.580.550] ... Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy. Biomolecules ... Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway. Nat ... Metabolic Reprogramming of Glioblastoma Cells during HCMV Infection Induces Secretome-Mediated Paracrine Effects in the ...
... this physiological phenomenon is normal. Typically, another physical sensation should occur at some point while one eats: ... increases the bodys blood sugar level so the body produces insulin to allow glucose to exit the bloodstream and enter cells ...
To better understand the electrical behavior of T-tubules of cardiac cells in health and disease, this study addresses two ... To better understand the electrical behavior of T-tubules of cardiac cells in health and disease, this study addresses two ... T-tubules are invaginations of the lateral membrane of striated muscle cells that provide a large surface for ion channels and ... T-tubules are invaginations of the lateral membrane of striated muscle cells that provide a large surface for ion channels and ...
Furthermore, we show that SPORK2 is indispensable for the JAG-triggered shrinkage of the motor cell. This is the first report ... Here, we report that JAG induces leaf-folding through accumulation of reactive oxygen species in the extensor motor cells of S ... It has been shown that the circadian rhythmic potassium flux from/into motor cells triggers cell shrinking/swelling to cause ... Although we did not perform calcium imaging experiments in S. saman, a similar phenomenon is presumed to be triggered by JAG in ...
Direct single-cell biomass estimates for marine bacteria via Archimedes principle.. ISME J. 2017; 11: 825-828. View in Article ... Despite their ubiquity in nature, we lack an understanding of how these behaviors emerge from cellular-scale phenomena. Here, ... Exploiting fine-scale genetic and physiological variation of closely related microbes to reveal unknown enzyme functions. ... Multicellular behaviour enables cooperation in microbial cell aggregates.. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2019; 374 ...
Programmed cell death (PCD), a physiological cell suicide process, occurs during the development of most organisms and is, ... Programmed cell death (PCD), a physiological cell suicide process, occurs during the development of most organisms and is, ... Programmed cell death (PCD), a physiological cell suicide process, occurs during the development of most organisms and is, ... Programmed cell death (PCD), a physiological cell suicide process, occurs during the development of most organisms and is, ...
VIRTUOUS embraces a disruptive paradigm concerning modelling physiological and pathological phenomena. The VIRTUOUS vision ... tongue has the potential to become a tool to help clinicians in preparing a diet to target specific cell receptors and cell ... Each taste represents a different nutritional or physiological need. ... between food chemical compounds and relative taste receptors trigger a subsequent cascade of events involving receptor cells ...
8.41,Algorithms,Cell Physiological Phenomena,Membrane Proteins,Membrane Proteins: chemistry,Membranes,Membranes: chemistry, ... We study two mechanisms for the formation of protein patterns near membranes of living cells by mathematical modelling. Self- ... whereas self-organization results in a pattern wavelength comparable to the typical cell size of 100 microm within a few ...
... species are key factors that strongly affect the cellular redox state and regulate various physiological and cellular phenomena ... Fluorescent sensor proteins capable of measuring in situ pH in animal cells have been reported. However, these proteins require ... However, such fluorescent probes are unsuitable for use in the cells of photosynthetic organisms because they require ... pH is one of the most critical physiological parameters determining vital cellular activities, such as photosynthetic ...
... axonal retraction and cell death. Alongside synaptic pathology, recent data suggest that Tau has physiological roles in the pre ... We collate here the myriad of emerging interactions and physiological roles of synaptic Tau, and discuss the current evidence ... analysis of Tau-interacting proteins suggests roles in scaffolding and transport with high enrichment at synapses and cell ...
Physiological phenomena. Models of hippocampus address several important physiological phenomena observed within the ... recent data suggests that place cells may not depend upon grid cell firing. The changes in place cell responses after movement ... Models of hippocampus simulate physiological phenomena or behavioral functions of the hippocampus, using the techniques of ... The place cell responses in region CA1 have been modeled using arrays of sensory features linked to place cell responses by ...
Cell Physiological Phenomena, Biological Transport/physiology, Cell Membrane/physiology, 32532 MIT OpenCurseWare: Quantitative ... Health Education, Education, Distance, Musculoskeletal System/physiopathology, Musculoskeletal Physiological Phenomena, Bone ...
... may partially model a physiological prophylaxis in the lung, cell test systems may inadvertently introduce a non-representative ... The only draw backs to and in vitro approach is that these techniques do no take lung clearance phenomena into consideration ... from inflammatory cells and not target cells. However, asbestos fiber can generate ROS spontaneously in cell-free systems. ... Topic #1: Physiological Fate of Asbestos and Vitreous Fibers less than 5 Microns in Length.. What is the expected physiological ...
If focal proteolysis is a key mechanism in mediating cell-cell interaction at the NMJ, this would hardly be a novel phenomenon ... The involvement of proteinases has been extensively reviewed, owing to their importance for a multitude of physiological and ... Cell Dev. Biol. 2009, 25, 161-195. [Google Scholar] [CrossRef] [PubMed]. *Burden, S.J. SnapShot: Neuromuscular Junction. Cell ... Werle, M.J. Cell-to-cell signaling at the neuromuscular junction: The dynamic role of the extracellular matrix. Ann. N. Y. Acad ...
On a physiological level, cells lining the gut increase their permeability - a phenomenon known as leaky gut. Heat stress also ... These cells are responsible for keeping toxins inside the gut and out of the bloodstream. "Enterocytes - the cells lining the ... "As a result of the vasoconstriction, the cells lining the gut suffer from hypoxia and die; this allows toxins such as LPS to ... The thermo-neutral zone for pigs can range from 18°C to 24°C, depending on the animals size, physiological status, air ...
Kim, D. H., Provenzano, P. P., Smith, C. L. & Levchenko, A., Apr 2012, In: Journal of Cell Biology. 197, 3, p. 351-360 10 p.. ... Provenzano, P. P., Eliceiri, K. W. & Keely, P. J., Nov 2009, In: Trends in Cell Biology. 19, 11, p. 638-648 11 p.. Research ... Provenzano, P. P., Eliceiri, K. W., Inman, D. R. & Keely, P. J., 2010, In: Current Protocols in Cell Biology. SUPPL. 47, p. ... Engineering three-dimensional collagen matrices to provide contact guidance during 3D cell migration. ...
Physiological Phenomena Medicine & Life Sciences 42% * Carcinogenesis Medicine & Life Sciences 31% * Cell Proliferation ... SPCA2-induced store-independent Ca2+ entry (SICE) plays essential roles in many important physiological processes, while ... SPCA2-induced store-independent Ca2+ entry (SICE) plays essential roles in many important physiological processes, while ... SPCA2-induced store-independent Ca2+ entry (SICE) plays essential roles in many important physiological processes, while ...
cell shape, cell function, cell physiological phenomena, ciliogenesis. J. Cell Biol. 2010;191(2):233-236. ... tumor cells, Micropatterns, H shape, Y shape, cell division, neoplasms, cell adhesion, cell line, cell shape, Cell polarity ... cell fate, cell division, cell shape, cell membrane, Cell polarity, actin dynamics, average distribution of actin-binding ... cilia, ciliogenesis, retinal dystrophy, actins, cytoskeleton, cell cycle, cell division, cell line, cell movement, cell shape, ...
Phenomena and Processes [G] » Reproductive and Urinary Physiological Phenomena [G08] » Reproductive Physiological Phenomena ... Cell Lineage Climacteric 7 drugs (2 approved, 5 experimental) Clutch Size Estrous Cycle ...
He has a long-standing interest in the molecular and cellular biology of physiological cell death (apoptosis) and in the ... Those interests have led to the characterization of the phenomenon of "innate apoptotic immunity," and to the identification of ... Ca2+ influx into apoptotic cells results in the redistribution of PS to the cell surface where it marks the dying cells for ... Apoptotic cells are recognized by phagocytes and neighboring cells, and trigger a profound repertoire of affirmative signaling ...
Child Nutritional Physiological Phenomena G7.610.220 G7.203.650.220 Chimera B1.50.50.530 B1.650.85 Chimerin 1 D12.776.402.150. ... B-Cell Activating Factor D12.644.276.972.61 D12.776.467.972.61 D23.529.972.61 B-Cell-Specific Activator Protein D12.776.930.626 ... Animal Nutritional Physiological Phenomena G7.610.161 G7.203.650.161 Animals, Congenic B1.50.50.157.40 B1.50.50.199.40 Animals ... Sports Nutritional Physiological Phenomena G7.610.830 G7.203.650.830 Spouse Abuse I1.198.240.856.575.500 I1.880.735.900.688.500 ...
Single cells are believed to be incapable of complex forms of learning, but reconsideration of historical studies and more ... which sought to establish links between physiological and psychological phenomena. Davis primarily conducted ... and human iNKT cells. Strikingly, we found that regulatory iNKT cells, such as adipose iNKT cells, undergo blunted activation, ... Single cells continue to surprise us. Robert Hooke, peering through his microscope in the 17th century, first likened cells to ...
Medical Research Future Fund (MRFF) Accelerator Research Stem Cell Program. Stem cells for sight: building the pathway from the ... Notably, we have also identified uncommon and unreported non-tumourgenic transformation phenomena on the corneal surface, some ... of which are pathological and some that might be physiological, i.e., attempt to self-resolve. Our goal is to characterise ... Identifying markers for these rare but important cell is key, and to this end, we are performing cutting-edge single cell RNA ...
The mechanism behind HER2 amplification is unknown, but may be a patho-physiological phenomenon caused by continuous ... to see whether non-cancer cells from these patients express a protein profile indicating general activation. Methods: Tissue ...
Ocular Physiological Phenomena, Psychophysics, Retinal Cone Photoreceptor Cells ...
This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation ... Using cell biological, biochemical, and genetic tools, we reveal that influenza A virus (IAV) infection induces global ... that ultimately cause global transcriptional downregulation of physiological transcripts, an effect influencing antiviral ... Exercise capacity and clinical outcomes in adults followed in the Cooperative Study of Sickle Cell Disease (CSSCD)External. ...
Data science in cell imaging. Driscoll, M. K. & Zaritsky, A., 1 Apr 2021, In: Journal of Cell Science. 134, 7, jcs254292.. ... Diagnostic and clinical significance of fetal cells in maternal blood circulation. Bashiri, A., Sheiner, E. & Mazor, M., 15 Jun ... Physiological Phenomena 23% 21 Scopus citations * Deviance and Risk on Holiday: An Ethnography of British Tourists in Ibiza. ...
  • Self-assembly produces periodic protein patterns on a spatial scale below 0.1 microm in a few seconds followed by extremely slow coarsening, whereas self-organization results in a pattern wavelength comparable to the typical cell size of 100 microm within a few minutes suggesting different biological functions for the two processes. (ptb.de)
  • SPCA2-induced store-independent Ca 2+ entry (SICE) plays essential roles in many important physiological processes, while unbalanced SICE leads to enhanced cell proliferation and tumorigenesis. (elsevier.com)
  • Physiological processes, factors, properties and characteristics pertaining to REPRODUCTION . (liu.edu)
  • The cellular processes involved in adjustments to the MITOCHONDRIAL VOLUME, content, and activity, that depend on the energy demands of the cell. (uams.edu)
  • The next step which is necessary for developing a systems biology that deals with systemic phenomena is to expand the existing and develop new methodologies that are appropriate to characterize intercellular processes and interactions without omitting the causal underlying molecular mechanisms. (who.int)
  • While the adipocyte has been studied for many years and remarkable insights have been gained about some processes, many areas of the physiology of the fat cell remain unexplored. (diabetesjournals.org)
  • The cerebral microvascular system is key to a large variety of cerebral processes, including oxygen and nutrient delivery to brain cells as well as blood flow regulation as a function of neural activity. (univ-toulouse.fr)
  • We study two mechanisms for the formation of protein patterns near membranes of living cells by mathematical modelling. (ptb.de)
  • We have mapped the protein concentrations of HER1-4 in breast cancer tissue, autologous reference tissue, normal breast tissue and serum samples, to see whether non-cancer cells from these patients express a protein profile indicating general activation. (hu-berlin.de)
  • Great care should be taken when interpreting the results of protein localisation and quantitative gene expression patterns using fluorescent proteins in experiments involving intracellular physiological change. (biomedcentral.com)
  • Because of the importance of IP3 receptors, the ubiquitin / proteasome pathway, and the Bcl-2 protein family to cell biology, this work is significant to both our understanding of normal physiology, and also to diseases, such as cancer and neurodegeneration. (upstate.edu)
  • This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation of an intrinsically disordered region (IDR) of NS1 expressed by the 1918 pandemic IAV strain. (cdc.gov)
  • Through research, they discovered a way to repair the protein and heal cell damage. (k2dweb.com)
  • Both are key components of the systems physiology toolbox, which allows study of the interactions between a condition (e.g., nutrition, physiological state) with tissue gene/protein expression and the associated changes in biological functions. (oregonstate.edu)
  • Physiological functions of the imprinted Gnas locus and its protein variants Galpha(s) and XLalpha(s) in human and mouse. (medlineplus.gov)
  • G-protein coupled receptors (GPCRs) take part in a wide range of vital regulations of our physiological actions. (mdm2-inhibitors.com)
  • Here, we report that JAG induces leaf-folding through accumulation of reactive oxygen species in the extensor motor cells of S. saman , and this occurs independently of plant hormone signaling. (nature.com)
  • The rhythm of this phenomenon is not affected by environmental conditions and occurs even under continuous light/dark conditions. (nature.com)
  • Programmed cell death (PCD), a physiological cell suicide process, occurs during the development of most organisms and is, typically, a complex dynamic trait. (elsevier.com)
  • Division of the vegetative cell occurs asymmetrically forming the mother cell and pre-spore, both containing a copy of the genome. (biomedcentral.com)
  • This is a classic adaptive response that enables cells to adjust to their external environment and occurs during chronic exposure to drugs and perhaps in physiological and pathological situations. (upstate.edu)
  • This phenomenon occurs in response to both physiologic levels of shear stress and a pathologic stimulus, particular matter exposure. (cdc.gov)
  • Scientists have established that this physiological phenomenon occurs when we sleep 1,2 . (elitenaturalhealthcare.com)
  • Since deformability is such a fundamental characteristics of blood cells, deviations in normal cell deformability can contribute to a range of pathological conditions, such as microvascular occlusion, tissue necrosis and organ failure, observed in diseases such as malaria caused by Plasmodium falciparum. (ubc.ca)
  • The demonstration that some disease states are mirrored by gene expression profiles in blood cells has stimulated the analyses of gene expression changes in blood cells in different physiological and pathological conditions, including aging [ 1 , 2 ]. (aging-us.com)
  • This phenomenon does not apply to pathological conditions and does not require special treatment. (babymagazinclub.com)
  • Describe plant biology at genetic, molecular, physiological, and organismal levels to integrate plant functionalities in a hierarchical manner, from individual cells to the biosphere. (cornell.edu)
  • Fluorescent proteins are powerful molecular biology tools that have been used to study the subcellular dynamics of proteins within live cells for well over a decade. (biomedcentral.com)
  • Program in Molecular and Integrative Physiological Sciences Department of Environmental Health. (bvsalud.org)
  • The course will build upon knowledge acquired through prior studies of cell and molecular biology, general physiology and human anatomy, as we focus primarily on the central nervous system. (coursera.org)
  • This biophysical characteristic is particularly relevant for cells in the circulatory system, such as red blood cells and white blood cells, because deformability determines the capacity for these cells to transit through the microvasculature. (ubc.ca)
  • We annotated PETs to pathways of KEGG database and compared the murine B16F1 melanoma transcriptome with three non-melanoma murine transcriptomes (Melan-a2 melanocytes, E14 embryonic stem cells, and E17.5 embryo). (biomedcentral.com)
  • Upregulation of cell cycle progression, MAPK, and PI3K/Akt pathways were more limited to certain region(s) of the pathway. (biomedcentral.com)
  • Recovery of cells from one of the activated pathways of regulated cell death. (nih.gov)
  • been associated with or connected with vital physiological pathways. (bio2009.org)
  • In a process called signal transduction, G proteins trigger a complex network of signaling pathways that ultimately influence many cell functions. (medlineplus.gov)
  • However, such fluorescent probes are unsuitable for use in the cells of photosynthetic organisms because they require photoexcitation that may change intracellular conditions and induce autofluorescence, primarily in chlorophylls. (jbc.org)
  • A living cell has many different receptors on its surface by the activation of which information is transferred to the intracellular spaces. (dojindo.com)
  • IP3 is an intracellular messenger molecule formed at the plasma membrane when hormones, neurotransmitters or drugs stimulate cells. (upstate.edu)
  • This might be done by increasing or prolonging the intracellular level of active drug, by blocking the capacity of the cell to repair the drug's damage, or by interfering with other survival measures (such as replica- tion delay) instituted by the cell during this critical period. (cdc.gov)
  • In the body, NAMPT exists in two forms: an intracellular form, which regulates the production of nicotinamide adenine dinucleotide (NAD+), an important molecule for the generation of energy in the cell. (eurekalert.org)
  • The highly correlated results unmistakably point to a systematic downregulation of mitochondrial activities, which we hypothesize aims to downgrade the mitochondria-mediated apoptosis and the dependency of cancer cells on angiogenesis. (biomedcentral.com)
  • The first concerns genes coding for mitochondrial energy metabolism, to see whether changes in blood cells mirror those found in other tissues and may thus correlate with the global decrease in maximum oxygen uptake. (aging-us.com)
  • Levels of PEX in these vascularized tissues suggest that it interacts with endothelial cell alphavbeta3 where it serves as a natural inhibitor of MMP-2 activity, thereby regulating the invasive behavior of new blood vessels. (embl.de)
  • Staining of such tissues with TSQ has demonstrated that zinc ions play very important roles in neuronal cell death, endocrine functions, and other physiological phenomena. (dojindo.com)
  • Microarray development changed the way biologists approach the holistic study of cells and tissues. (oregonstate.edu)
  • Sometimes the phenomenon of 'additional' tissues is observed in children. (babymagazinclub.com)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
  • Reactive oxygen species are key factors that strongly affect the cellular redox state and regulate various physiological and cellular phenomena. (jbc.org)
  • Epithelial cells have the ability to regulate paracellular permeability dynamically in response to extracellular stimuli. (cdc.gov)
  • Looking at the nucleus accumbens - a brain region that regulates motivated behaviors - of both the socially impaired and healthy, 'control", mice, the researchers identified lower NAD+ levels and problems with the enzyme Sirtuin-1, an enzyme that depends on NAD+ to regulate the expression of genes involved in helping the cell regulate itself in response to stressors. (eurekalert.org)
  • Despite their ubiquity in nature, we lack an understanding of how these behaviors emerge from cellular-scale phenomena. (cell.com)
  • pH is one of the most critical physiological parameters determining vital cellular activities, such as photosynthetic performance. (jbc.org)
  • It carries messages that help in muscle contraction, nerve cell signal transmission, hormone secretion, immune cell activation, and other cellular functions. (dojindo.com)
  • The effects of IP3 are mediated by proteins called IP3 receptors, channels that govern the release of calcium ions from the endoplasmic reticulum into the cell cytosol: this "calcium mobilization" is a central part of many cellular functions. (upstate.edu)
  • This is exciting because the ubiquitin / proteosome pathway is currently one of the "hot areas" of cell biology - is it becoming increasingly apparent that this pathway is the mechanism by which many important cellular proteins and misfolded proteins in the endoplasmic reticulum are degraded and is of major relevance to diseases (e.g. cancer, neurodegeneration, diabetes). (upstate.edu)
  • Through the selection of suitable clinically useful alkylating agents (those dependent on active cellular transport for cell penetration) and appropriate MX scheduling, an enhanced therapeutic ratio might be achieved, potentially increasing the clinical usefulness of these alkylating agents. (cdc.gov)
  • Multiple and different cellular activities have already been related to the PP-InsPs, but an over-arching hypothesis sights them as performing as an user interface between energy fat burning capacity and cell-signaling [3,5,6]. (immune-source.com)
  • Viral infection perturbs host cells and can be used to uncover regulatory mechanisms controlling cellular responses and susceptibility to infections. (cdc.gov)
  • A special class of eukaryotic TFs, called pioneer factors, are the first to bind during cellular differentiation and reprogramming, facilitating the binding of non-pioneer transcription factors and initiating gene cascades associated with the new cell type. (genestogenomes.org)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
  • T-tubules are invaginations of the lateral membrane of striated muscle cells that provide a large surface for ion channels and signaling proteins, thereby supporting excitation-contraction coupling. (frontiersin.org)
  • To better understand the electrical behavior of T-tubules of cardiac cells in health and disease, this study addresses two largely unanswered questions regarding their electrical properties: (1) the delay of T-tubular membrane depolarization and (2) the effects of T-tubular sodium current on T-tubular potentials. (frontiersin.org)
  • Transverse (T-)tubules are deep invaginations of the lateral membrane of skeletal and cardiac muscle cells. (frontiersin.org)
  • DVar7 can allosterically insert into the tumor cell membrane in the acidic tumor microenvironment to enhance the tumor uptake of liposomes and prolong the retention time of liposomes in tumor. (dovepress.com)
  • We report that increased membrane septin-2 localization mediates decreases in paracellular permeability by altering cortical actin arrangement in human airway epithelial cells. (cdc.gov)
  • Models of hippocampus simulate physiological phenomena or behavioral functions of the hippocampus , using the techniques of computational neuroscience . (scholarpedia.org)
  • Other functional models assume specific response patterns such as place cells and predict behavioral results such as goal-directed behavior on this basis. (scholarpedia.org)
  • In fact, there is a substantial body of rigorous scientific evidence which shows that what is widely regarded as animal cognition is also found in plants, down to its physiological and behavioral basis. (springer.com)
  • There are a growing number of reports which correlate synthetic cannabinoids and acute behavioral and physiological effects including acute kidney injury, convulsions, and sudden death. (springeropen.com)
  • A fragment of MMP-2, which comprises the C-terminal hemopexin-like domain, termed PEX, prevents this enzyme binding to alphavbeta3 and blocks cell surface collagenolytic activity. (embl.de)
  • Initial GI symptoms are thought to be due to the virus's S1 spike protein's binding to the angiotensin-converting enzyme 2 receptors , which are abundant in GI epithelial cells. (medscape.com)
  • These receptors are essential in human beings physiologically, taking part in the rules of all of our physiological activities such as for example neurotransmission, enzyme launch, inflammation or chemotaxis, aswell as our feeling of vision, taste and smell, by sensing endogenous or environmental stimuli through binding suitable ligands and AZD-3965 IC50 transducing related sign into cells typically through combined heterotrimeric G proteins. (mdm2-inhibitors.com)
  • Une recherche documentaire a été effectuée dans PubMed de 1980 à 2021 en utilisant diverses combinaisons de termes MeSH comme tabac, diabète, hypertension, dyslipidémie, trouble dépressif majeur, trouble bipolaire, schizophrénie. (bvsalud.org)
  • Melanin biosynthesis genes were solely expressed in the cells of melanocytic origin, indicating the feasibility of using the PET approach for transcriptome comparison. (biomedcentral.com)
  • Despite the critical nature of these cell-to-cell interactions, much more is known about genes regulating EC versus MC function. (wustl.edu)
  • Another study was specifically focused on the identification of genes related to increased longevity and thus compared gene expression profiles in blood cells from nonagenarians with their middle-age offspring using the partners of the offspring as population controls [ 4 ]. (aging-us.com)
  • Using cell biological, biochemical, and genetic tools, we reveal that influenza A virus (IAV) infection induces global transcriptional defects at the 3' ends of active host genes and RNA polymerase II (RNAPII) run-through into extragenic regions. (cdc.gov)
  • The systems root these phenomena have already been examined [7]C[11] thoroughly, but it is probable that many from the genes and regulatory systems involved have however to be discovered. (bio2009.org)
  • A few of these focus on genes are portrayed specifically in Ha sido cells aswell Lurasidone (SM13496) IC50 such as the ICM of blastocysts. (bio2009.org)
  • In individual Ha sido cells 581 genes have already been defined as Oct3/4-focus on genes, whereas 963 genes have already been discovered in mouse Ha sido cells. (bio2009.org)
  • The appearance patterns of the genes in ZHTc6 cells and ZHBTc4 cells had been analyzed separately utilizing a k-means clustering algorithm and grouped into ten clusters (Amount 1B, C). Top panels display the expression adjustments of specific genes within a 3D landscaping map, whereas lower sections show the design of averaged gene appearance changes and the amount of genes grouped into each cluster. (bio2009.org)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • When vegetative cells encounter conditions of stress such as starvation the sporulation cycle is induced. (biomedcentral.com)
  • The work in my laboratory focuses on the establishment of specific cell fates using genomics to decipher interactions between chromatin and developmental signaling cascades, between genomes and rapidly evolving cell types, and between genomic copy number variation and gene expression. (stanford.edu)
  • As sporulation initiates, cells undergo an asymmetric division leading to differential gene expression in the small prespore and large mother cell compartments. (biomedcentral.com)
  • Gene expression is controlled temporally by a subset of sigma factors in both the developing spore and mother cell. (biomedcentral.com)
  • Blood cells provide an easily available tissue and gene expression profiles from whole blood samples appear to mirror disease states and some aspects of the aging process itself. (aging-us.com)
  • Careful regulation of gene expression is crucial to the health of an organism, as misregulation can have severe physiological consequences. (genestogenomes.org)
  • Journal of Cell Biology. (umn.edu)
  • Current Protocols in Cell Biology. (umn.edu)
  • Trends in Cell Biology. (umn.edu)
  • Frontiers in Cell and Developmental Biology. (edu.au)
  • There are many situations in medicine and biology where it is desirable to sort cells in a heterogeneous sample based on their mechanical deformability, which can potentially serve as a proxy for morphology or pathology. (ubc.ca)
  • Address correspondence and reprint requests to Departments of Cell Biology and Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461. (diabetesjournals.org)
  • Up to now, research in to the biology of inositol phosphate kinases continues to be well-served by hereditary research, including gene knock-outs both in microorganisms and cultured cells. (immune-source.com)
  • Metabolic Reprogramming of Glioblastoma Cells during HCMV Infection Induces Secretome-Mediated Paracrine Effects in the Microenvironment. (harvard.edu)
  • Facultative multicellular behaviors expand the metabolic capacity and physiological resilience of bacteria. (cell.com)
  • Intro Inositol phosphate kinases (IP3K, IPMK, ITPK1, IP5K, IP6K and PPIP5K) perform several biological procedures through their involvement inside a carefully-regulated, metabolic network that changes phospholipase C-derived Ins(1,4,5)P3 into a range of even more extremely phosphorylated cell-signaling substances [1C3]. (immune-source.com)
  • These cells are responsible for keeping toxins inside the gut and out of the bloodstream. (allaboutfeed.net)
  • Glucose is the main source of fuel for our cells and the amount of glucose present in our bloodstream is controlled by Insulin, a hormone created by the pancreas. (ultrahuman.com)
  • Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy. (harvard.edu)
  • Antiresorptive drugs (ARD) are bone metabolism patients, resulting in increased bone density, reduced risk modulators widely used in patients with some physiological of fractures and improved quality of life of individuals4,5. (bvsalud.org)
  • abstract = "Recent studies in secretory pathway calcium ATPases (SPCA) revealed novel functions of SPCA2 in interacting with store-operated Ca2+ channel Orai1 and inducing Ca2+ influx at the cell surface. (elsevier.com)
  • We communicate through symbols which are generally commonly-agreed-upon abstract representations of real-world objects and phenomena. (philosophytoday.in)
  • Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization. (bvsalud.org)
  • The process that reverts CELL NUCLEI of fully differentiated somatic cells to a pluripotent or totipotent state. (bvsalud.org)
  • Fluorescent sensor proteins capable of measuring in situ pH in animal cells have been reported. (jbc.org)
  • Bioinformatics analysis of Tau-interacting proteins suggests roles in scaffolding and transport with high enrichment at synapses and cell junctions. (biomedcentral.com)
  • However, since most zinc ions are strongly combined with proteins, the concentration of free zinc ions in a cell is at the millimolar level or lower. (dojindo.com)
  • Background: Galectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the anticancer activities of T lymphocytes and natural killer cells. (diamond.ac.uk)
  • Two transcription elements, (and (variant homeobox proteins) [15], [16] are recognized to play essential assignments in mouse Ha sido cells. (bio2009.org)
  • In blastocysts, Oct3/4 proteins is more loaded in the ICM than in trophectoderm cells, however in later blastocysts Oct3/4 proteins is even more loaded in primitive endoderm than in the ICM [18] also. (bio2009.org)
  • On a physiological level, cells lining the gut increase their permeability - a phenomenon known as leaky gut. (allaboutfeed.net)
  • With every respiratory effort, airway epithelial cells are exposed to both physiologic as well as pathologic stimuli, and regulation of the epithelial barrier in response to these stimuli is crucial to respiratory function. (cdc.gov)
  • The resulting changes in barrier function in response to septin-2 redistribution have a significant impact on the ability of the apical ligand, epidermal growth factor, to interact with its receptor, epidermal growth factor receptor, which is segregated to the basolateral side in airway epithelial cells. (cdc.gov)
  • The lowest passage WNV available were used for crow virulence studies to avoid incorporating confounding cell-culture-related genetic substitutions. (cdc.gov)
  • Deregulated RNAPII leads to expression of aberrant RNAs (3' extensions and host-gene fusions) that ultimately cause global transcriptional downregulation of physiological transcripts, an effect influencing antiviral response and virulence. (cdc.gov)
  • MCs, a perivascular cell population that provides structural support to EC tube networks, can be split into subclasses, including smooth muscle cells and pericytes, based on the anatomical location of the MC population within the vascular network. (wustl.edu)
  • The interactions between food chemical compounds and relative taste receptors trigger a subsequent cascade of events involving receptor cells linked to the nervous system, ultimately resulting in the perception of a specific taste. (ercim.eu)
  • Our primary focus at the moment is analyzing IP3 receptor down-regulation - a remarkable phenomenon by which IP3 receptors are rapidly depleted from cells when they are stimulated (see diagram). (upstate.edu)
  • 58. Pearce, M.M., Wang, Y., Kelley, G.G. and Wojcikiewicz, R.J.H. (2007) SPFH2 mediates the ERAD of IP3 receptors and other substrates in mammalian cells. (upstate.edu)
  • Furthermore, human being FPR expression continues to be observed in several distinct cells and cell types ([6]C[7] and sources therein), indicating a much broad distribution of the receptors and their significant role in vivo physiologically. (mdm2-inhibitors.com)
  • With a particular focus in pancreatic cancer, the company's mission is to develop novel oncology therapies founded on technology that selectively targets overexpressed receptors on cancer cells. (missouritechnology.com)
  • These differences in gene activation based on the gene's parent of origin are caused by a phenomenon called genomic imprinting. (medlineplus.gov)
  • This approach can be adapted to any pioneer factor, cell type, genomic locus, and repressive histone modification. (genestogenomes.org)
  • As in previous lectures, I will illustrate some of the basic human genetic phenomena through case studies, in this case ranging from calico cats to the human genetic disorders of Angelman and Prader-Willi syndromes. (coursera.org)
  • To build a functionally stable blood vessel that is able to withstand changes in shear stress and modulate vascular tone requires cooperation between two cell types: the endothelial cell (EC) and the mural cell (MC). (wustl.edu)
  • The mechanism behind HER2 amplification is unknown, but may be a patho-physiological phenomenon caused by continuous stimulation and activation of the HER1-4 system. (hu-berlin.de)
  • This dissertation presents an improved microfiltration strategy performed using the microfluidic ratchet mechanism, which relies on the deformation of individual cells through micrometer-scale tapered constrictions. (ubc.ca)
  • This work demonstrates the utility of the ratchet mechanism for cell sorting by developing a microfluidic device to sort red blood cells based on deformability. (ubc.ca)
  • But why patients have long-term GI sequelae is probably a whole different physiological mechanism," Trindade said. (medscape.com)
  • The prin- ciple has two aspects: (1) that complex mental phenomena are formed from simple elements derived ultimately from sensations and (2) that the mechanism by which these are formed depends on similarity and/or repeated juxtaposition of the simple elements in space and time. (virginia.edu)
  • Angiogenesis depends on both cell adhesion and proteolytic mechanisms. (embl.de)
  • The difficulties in model development for these endpoints can be attributed to the complex mechanisms relevant to the toxicity phenomena. (rutgers.edu)
  • The appearance of Oct3/4 is fixed to pluripotent embryonic and germline cells [17]. (bio2009.org)
  • Organoids from human pluripotent cells can be used to model cerebral cortical development. (jcbose.ac.in)
  • You can watch the film on the screen, and get so absorbed, that you'll have emotional and physiological responses, but the movie isn't real. (karenshanley.com)
  • Whatever the source of this differential activity, it seems likely to involve the exposure of the cell to DNA damage during S phase. (cdc.gov)
  • One means of increasing the cells' sensitivity to S-phase damage would be to render sublethal damage more toxic. (cdc.gov)
  • I shall discuss about our very recent findings of wobbling motion in 183Au nucleus, which is a common phenomenon for an asymmetric top in the classical world but an extremely rare one in atomic nuclei. (jcbose.ac.in)
  • Tumor microenvironment (TME), supporting the survival and development of cancer cells, has the special physical and chemical characteristic, such as low concentration of oxygen and low pH value, which not only play a key role in tumor progression and metastasis but also has an obvious impact on the therapeutic efficacy of tumors. (dovepress.com)
  • 1-4 In the acidic microenvironment of tumors, weakly alkaline drug molecules are easily protonated, preventing them from entering tumor cells and thus causing drug resistance. (dovepress.com)
  • The relationships between DNA damage from UV radiation, alkylating drugs and the methylated xanthines (MX) have been studied in normal and malignant rodent and human cells. (cdc.gov)
  • A comparison of the level of DNA excision repair (repair replication and unscheduled DNA synthesis) confirms that some forms of alkylating- agent damage (probably mono-filar DNA adducts) are less completely removed by both normal and malignant rodent cells than by their human counterparts, rendering rodent cells more susceptible to the toxic potential of unexcised lesions. (cdc.gov)
  • Human cells appear capable of excising more DNA damage, rendering them somewhat less susceptible to enhancement of cytotoxicity by MX. (cdc.gov)
  • This resistance of human cells is only quanti- tative, however, since 2 human cancer cell lines (HeLa and HT-29) could be sensitized to a variety of alkylating agents by appropriate concentrations of MX. (cdc.gov)
  • This phenomenon indicates that the N-formyl group is not essential for ligand binding to AZD-3965 IC50 human FPRs. (mdm2-inhibitors.com)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • The correspondence is usually clear but there's a significant degree of fuzziness involved owing to unavoidable subjectivity inherent in even the most standardised definitions as well as differential human perception and understanding of objects and phenomena. (philosophytoday.in)
  • We now turn our attention from the tangible (human neuroanatomy) to the physiological as we explore the means by which neurons generate, propagate and communicate electrical signals. (coursera.org)
  • Results of enzymic analysis provided here suggest that a previously defined deficiency of aspartase (AspA) accounts for this phenomenon rather than an elevated oxaloacetate pool. (microbiologyresearch.org)
  • The extremely high physiological stress around calving leads Selleckchem HSP inhibitor to decline of fertility rates and prolonged number of open days, which are risk factors of rentability. (ainhibitor.com)
  • The fabrication, operating principle, and applications of these systems and their capacity for in vivo analysis and optical imaging at the single-cell level are discussed. (nih.gov)
  • In this work, our goal is to develop models for hemodynamics and mass transport in the brain microcirculation, which can be later coupled with in-vivo measurement to understand and solve physiological problems involved in pathologies. (univ-toulouse.fr)
  • Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway. (harvard.edu)
  • Circadian rhythmic leaf-folding, called nyctinasty, is a widely observed physiological behavior of leguminous plants 1 , 2 , wherein the plants open their leaves in the morning and fold them in the evening. (nature.com)