Dictionaries, MedicalCell Nucleus Structures: Structures that are part of or contained in the CELL NUCLEUS.Plastic Embedding: The infiltrating of histological specimens with plastics, including acrylic resins, epoxy resins and polyethylene glycol, for support of the tissues in preparation for sectioning with a microtome.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Dictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Dictionaries, ChemicalActive Transport, Cell Nucleus: Gated transport mechanisms by which proteins or RNA are moved across the NUCLEAR MEMBRANE.Intervertebral Disc: Any of the 23 plates of fibrocartilage found between the bodies of adjacent VERTEBRAE.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Electron Microscope Tomography: A tomographic technique for obtaining 3-dimensional images with transmission electron microscopy.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Gene Products, tat: Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. tat stands for trans-activation of transcription.HIV-1: The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)tat Gene Products, Human Immunodeficiency Virus: Proteins encoded by the TAT GENES of the HUMAN IMMUNODEFICIENCY VIRUS.Infectious Disease Incubation Period: The amount time between exposure to an infectious agent and becoming symptomatic.Gadolinium DTPA: A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)Carbon Compounds, Inorganic: Inorganic compounds that contain carbon as an integral part of the molecule but are not derived from hydrocarbons.Noise: Any sound which is unwanted or interferes with HEARING other sounds.Silicon Compounds: Inorganic compounds that contain silicon as an integral part of the molecule.Noise, Occupational: Noise present in occupational, industrial, and factory situations.Occupational Health: The promotion and maintenance of physical and mental health in the work environment.Occupational Health Services: Health services for employees, usually provided by the employer at the place of work.Hearing Loss, Noise-Induced: Hearing loss due to exposure to explosive loud noise or chronic exposure to sound level greater than 85 dB. The hearing loss is often in the frequency range 4000-6000 hertz.Cryopreservation: Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.Cryoprotective Agents: Substances that provide protection against the harmful effects of freezing temperatures.Glycerol: A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.Semen Preservation: The process by which semen is kept viable outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).Tissue Preservation: The process by which a tissue or aggregate of cells is kept alive outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).Time Factors: Elements of limited time intervals, contributing to particular results or situations.Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.National Library of Medicine (U.S.): An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.Australian Capital Territory: A territory of Australia consisting of Canberra, the national capital and surrounding land. It lies geographically within NEW SOUTH WALES and was established by law in 1988.Australia: The smallest continent and an independent country, comprising six states and two territories. Its capital is Canberra.MEDLARS: A computerized biomedical bibliographic storage and retrieval system operated by the NATIONAL LIBRARY OF MEDICINE. MEDLARS stands for Medical Literature Analysis and Retrieval System, which was first introduced in 1964 and evolved into an online system in 1971 called MEDLINE (MEDLARS Online). As other online databases were developed, MEDLARS became the name of the entire NLM information system while MEDLINE became the name of the premier database. MEDLARS was used to produce the former printed Cumulated Index Medicus, and the printed monthly Index Medicus, until that publication ceased in December 2004.Libraries, MedicalGrateful Med: A microcomputer-based software package providing a user-friendly interface to the MEDLARS system of the National Library of Medicine.MedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.High-Energy Shock Waves: High-amplitude compression waves, across which density, pressure, and particle velocity change drastically. The mechanical force from these shock waves can be used for mechanically disrupting tissues and deposits.Vacuum: A space in which the pressure is far below atmospheric pressure so that the remaining gases do not affect processes being carried on in the space.Lithotripsy: The destruction of a calculus of the kidney, ureter, bladder, or gallbladder by physical forces, including crushing with a lithotriptor through a catheter. Focused percutaneous ultrasound and focused hydraulic shock waves may be used without surgery. Lithotripsy does not include the dissolving of stones by acids or litholysis. Lithotripsy by laser is LITHOTRIPSY, LASER.Wound Healing: Restoration of integrity to traumatized tissue.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Kidney Calculi: Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.Wound Infection: Invasion of the site of trauma by pathogenic microorganisms.Gynecomastia: Enlargement of the BREAST in the males, caused by an excess of ESTROGENS. Physiological gynecomastia is normally observed in NEWBORNS; ADOLESCENT; and AGING males.Anabolic Agents: These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.Weight Lifting: A sport in which weights are lifted competitively or as an exercise.Promazine: A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)Digoxin: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)

FISH analysis of six chromosomes in unfertilized human oocytes after polar body removal. (1/173)

PURPOSE: To develop an improved technique for estimating chromosomal abnormalities in human oocytes by fluorescence in situ hybridization (FISH) and to correlate the position of single chromatids with the chromosomal status of the oocytes. METHODS: Oocytes that were at metaphase II about 17-20 hr after insemination or intracytoplasmic sperm injection (ICSI) were treated with pronase to remove the zona pellucida and polar body (PB) and then spread on slides using HCl and Tween 20. Two rounds of FISH were performed using direct-labeled probes: chromosomes 1, 13, 21 (round 1); chromosomes X, 7, 18 (round 2). RESULTS: Of the 63 oocytes from 18 patients (mean age, 32 years), 48 (76%) had one DNA complement as expected, 9 (14%) had 2 DNA complements, 3 (5%) gave incomplete FISH signals, and 3 (5%) were not analyzable. Of the 48 oocytes with one set of DNA, 48% were haploid, 44% were aneuploid for one or more chromosomes, and 8% were polyploid. We also found an increased frequency of predivision of chromatid bivalents in aneuploid oocytes, especially for chromosome 21. CONCLUSIONS: This technique enables simultaneous assessment of six chromosomes in human oocytes, and therefore can be useful for accurately determining the incidence and causes of genetic imbalances in human oocytes and apparently low fertilization rates.  (+info)

Formation of nuclear HSF1 granules varies depending on stress stimuli. (2/173)

In concert with the stress-induced activation of human heat shock factor 1 (HSF1), the factor becomes inducibly phosphorylated and accumulates into nuclear granules. To date, these processes are not fully understood. Here, we show that although stress caused by the proteasome inhibitors MG132 and clasto-lactacystine beta-lactone induces the expression of Hsp70, the formation of HSF1 granules is affected differently in comparison to heat shock. Furthermore, proteasome inhibition increases serine phosphorylation on HSF1, but to a lesser extent than heat stress. Our results suggest that, depending on the type of stress stimulus, the multiple events associated with HSF1 activation might be affected differently.  (+info)

ICP0 induces the accumulation of colocalizing conjugated ubiquitin. (3/173)

Herpes simplex virus type 1 (HSV-1) immediate-early protein ICP0 is a general activator of viral gene expression which stimulates the initiation of lytic infection and reactivation from quiescence and latency. The importance of ICP0 to the biology of HSV-1 infection has stimulated interest in its mode of action. Previous studies have reported its interactions with other viral regulatory molecules, with the translation apparatus, with cyclin D3, and with a ubiquitin-specific protease. It has been demonstrated that ICP0 is able to induce the proteasome-dependent degradation of a number of cellular proteins, including components of centromeres and small nuclear substructures known as ND10 or PML nuclear bodies. ICP0 has a RING finger zinc-binding domain which is essential for its functions. In view of several recent examples of other RING finger proteins which modulate the stability of specific target proteins by acting as components of E3 ubiquitin ligase complexes, this study has explored whether ICP0 might operate via a similar mechanism. Evidence that the foci of accumulated ICP0 in transfected and infected cells contain enhanced levels of conjugated ubiquitin is presented. This effect was dependent on the RING finger region of ICP0, and comparison of the properties of a number of ICP0 mutants revealed an excellent correlation between previously established functions of ICP0 and its ability to induce concentrations of colocalizing conjugated ubiquitin. These results strongly support the hypothesis that a major factor in the mechanism by which ICP0 influences virus infection is its ability to induce the degradation of specific cellular targets by interaction with the ubiquitin-proteasome pathway.  (+info)

Alphaherpesvirus proteins related to herpes simplex virus type 1 ICP0 affect cellular structures and proteins. (4/173)

The herpes simplex virus type 1 (HSV-1) immediate-early protein ICP0 interacts with several cellular proteins and induces the proteasome-dependent degradation of others during infection. In this study we show that ICP0 is required for the proteasome-dependent degradation of the ND10 protein Sp100 and, as with the other target proteins, the ICP0 RING finger domain is essential. Further, comparison of the kinetics and ICP0 domain requirements for the degradation of PMI and Sp100 suggests that a common mechanism is involved. Homologues of ICP0 are encoded by other members of the alphaherpesvirus family. These proteins show strong sequence homology to ICP0 within the RING finger domain but limited similarity elsewhere. Using transfection assays, we have shown that all the ICP0 homologues that we tested have significant effects on the immunofluorescence staining character of at least one of the proteins destabilized by ICP0, and by using a recombinant virus, we found that the equine herpesvirus ICP0 homologue induced the proteasome-dependent degradation of endogenous CENP-C and modified forms of PML and Sp100. However, in contrast to ICP0, the homologue proteins had no effect on the distribution of the ubiquitin-specific protease USP7 within the cell, consistent with their lack of a USP7 binding domain. We also found that ICP0 by itself could induce the abrogation of SUMO-1 conjugation and then the proteasome-dependent degradation of unmodified exogenous PML in transfected cells, thus demonstrating that other HSV-1 proteins are not required. Surprisingly, the ICP0 homologues were unable to cause these effects. Overall, these data suggest that the members of the ICP0 family of proteins may act via a similar mechanism or pathway involving their RING finger domain but that their intrinsic activities and effects on endogenous and exogenous proteins differ in detail.  (+info)

DNA replication progresses on the periphery of nuclear aggregates formed by the BCL6 transcription factor. (5/173)

The BCL6 proto-oncogene, frequently alterated in non-Hodgkin lymphoma, encodes a POZ/zinc finger protein that localizes into discrete nuclear subdomains. Upon prolonged BCL6 overexpression in cells bearing an inducible BCL6 allele (UTA-L cells), these subdomains apparently coincide with sites of DNA synthesis. Here, we explore the relationship between BCL6 and replication by both electron and confocal laser scanning microscopy. First, by electron microscope analyses, we found that endogenous BCL6 is associated with replication foci. Moreover, we show that a relatively low expression level of BCL6 reached after a brief induction in UTA-L cells is sufficient to observe its targeting to mid, late, and at least certain early replication foci visualized by a pulse-labeling with bromodeoxyuridine (BrdU). In addition, when UTA-L cells are simultaneously induced for BCL6 expression and exposed to BrdU for a few hours just after the release from a block in mitosis, a nuclear diffuse BCL6 staining indicates cells in G(1), while cells in S show a more punctate nuclear BCL6 distribution associated with replication foci. Finally, ultrastructural analyses in UTA-L cells exposed to BrdU for various times reveal that replication progresses just around, but not within, BCL6 subdomains. Thus, nascent DNA is localized near, but not colocalized with, BCL6 subdomains, suggesting that they play an architectural role influencing positioning and/or assembly of replication foci. Together with its previously function as transcription repressor recruiting a histone deacetylase complex, BCL6 may therefore contribute to link nuclear organization, replication, and chromatin-mediated regulation.  (+info)

The matrix protein of vesicular stomatitis virus inhibits nucleocytoplasmic transport when it is in the nucleus and associated with nuclear pore complexes. (6/173)

The matrix (M) protein of vesicular stomatitis virus (VSV) is a potent inhibitor of bidirectional nuclear transport. Here we demonstrate that inhibition occurs when M protein is in the nucleus of Xenopus laevis oocytes and that M activity is readily reversed by a monoclonal antibody (alphaM). We identify a region of M protein, amino acids 51 to 59, that is required both for inhibition of transport and for efficient recognition by alphaM. When expressed in transfected HeLa cells, M protein colocalizes with nuclear pore complexes (NPCs) at the nuclear rim. Moreover, mutation of a single amino acid, methionine 51, eliminates both transport inhibition and targeting to NPCs. We propose that M protein inhibits bidirectional transport by interacting with a component of the NPC or an NPC-associated factor that participates in nucleocytoplasmic transport.  (+info)

Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes. (7/173)

Caenorhabditis elegans has a single lamin gene, designated lmn-1 (previously termed CeLam-1). Antibodies raised against the lmn-1 product (Ce-lamin) detected a 64-kDa nuclear envelope protein. Ce-lamin was detected in the nuclear periphery of all cells except sperm and was found in the nuclear interior in embryonic cells and in a fraction of adult cells. Reductions in the amount of Ce-lamin protein produce embryonic lethality. Although the majority of affected embryos survive to produce several hundred nuclei, defects can be detected as early as the first nuclear divisions. Abnormalities include rapid changes in nuclear morphology during interphase, loss of chromosomes, unequal separation of chromosomes into daughter nuclei, abnormal condensation of chromatin, an increase in DNA content, and abnormal distribution of nuclear pore complexes (NPCs). Under conditions of incomplete RNA interference, a fraction of embryos escaped embryonic arrest and continue to develop through larval life. These animals exhibit additional phenotypes including sterility and defective segregation of chromosomes in germ cells. Our observations show that lmn-1 is an essential gene in C. elegans, and that the nuclear lamins are involved in chromatin organization, cell cycle progression, chromosome segregation, and correct spacing of NPCs.  (+info)

A chromatin insulator determines the nuclear localization of DNA. (8/173)

Chromatin insulators might regulate gene expression by controlling the subnuclear organization of DNA. We found that a DNA sequence normally located inside of the nucleus moved to the periphery when the gypsy insulator was placed within the sequence. The presence of the gypsy insulator also caused two sequences, normally found in different regions of the nucleus, to come together at a single location. Alterations in this subnuclear organization imposed by the gypsy insulator correlated with changes in gene expression that took place during the heat-shock response. These global changes in transcription were accompanied by dramatic alterations in the distribution of insulator proteins and DNA. The results suggest that the nuclear organization imposed by the gypsy insulator on the chromatin fiber is important for gene expression.  (+info)

*Replication timing

... and chromosome structure[edit]. Figure 5. Nucleus of a female amniotic fluid cell. Top: Both X-chromosome ... In eukaryotic cells (cells that package their DNA within a nucleus), chromosomes consist of very long linear double-stranded ... It was also noticed by Mary Lyon [9] that the inactive X took on a condensed structure in the nucleus called the Barr body [10] ... all of the DNA in a cell is duplicated in order to provide one copy to each of the daughter cells after the next cell division ...

*Epigenetics of neurodegenerative diseases

... valproic acid had a neuroprotective effect by preventing translocation of alpha-synuclein into cell nuclei.[24]. Vorinostat. In ... DNA-histone structures form constitutive heterochromatin. This chromatin structure is mediated by these three levels of gene ... doi:10.1016/j.cell.2007.01.033. PMID 17320505.. *^ a b c Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, ... The Journal of Cell Biology. 191 (2): 367-81. doi:10.1083/jcb.201008051. PMC 2958468. PMID 20937701.. ...

*Heart

... and surrounded by pericardial cells (red). Blue depicts cell nuclei. ... This distinction is visible also on the surface of the heart as the coronary sulcus.[18] There is an ear-shaped structure in ... The muscle cells make up the bulk (99%) of cells in the atria and ventricles. These contractile cells are connected by ... There are two types of cells in cardiac muscle: muscle cells which have the ability to contract easily, and pacemaker cells of ...

*Eicosanoid

The cell must realize some benefit from generating lipid hydroperoxides close-by its nucleus. PGs and LTs may signal or ... Structures of selected eicosanoids Prostaglandin E1. The 5-member ring is characteristic of the class. Thromboxane A2. Oxygens ... The oxidation of lipids is hazardous to cells, particularly when close to the nucleus. There are elaborate mechanisms to ... agents to impact their cells of origin or as paracrine signaling agents to impact cells in the proximity of their cells of ...

*Symbiogenesis

... the cell more energy to develop a nuclear membrane than if the cell was to fold its cell membrane to develop this structure ... Viral eukaryogenesis, hypothesis that the cell nucleus originated from endosymbiosis. References[edit]. *^ "Mereschkowsky's ... On the origin of mitosing cells.[16] In her 1981 work Symbiosis in Cell Evolution she argued that eukaryotic cells originated ... If a cell's mitochondria or chloroplasts are removed, the cell does not have the means to create new ones.[54] For example, in ...

*Caulimoviridae

Replication takes place in both the cytoplasm and nucleus of host cells. Firstly, the viral genome enters the cytoplasm. The ... viral DNA forms supercoiled mini-chromosome structures upon entering the host nucleus. The viral DNA is transcribed into ... This DNA can then reenter the nucleus for amplification. As replication requires the use of RNA intermediate, viruses from the ... The type of nucleocapsid incorporated into the virus structure determines the size of the virus. Bacilliform nucleocapsid ...

*Actinic keratosis

These cells have been observed to proliferate into the dermis as buds and duct-like structures.[22] ... cytologic atypia such as abnormally large nuclei, and a mild chronic inflammatory infiltrate.[6] ... It works in two ways, first by disrupting cell membranes and mitochondria resulting cell death, and then by inducing antibody- ... Moy, RL (Jan 2000). "Clinical presentation of actinic keratoses and squamous cell carcinoma". Journal of the American Academy ...

*Histone H2A

... is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Histones are ... DNA modification by H2A occurs in the cell nucleus. Proteins responsible for nuclear import of H2A protein are karyopherin and ... however the genetic sequence that encodes for this structure differs between variants. The structure of macroH2A variant was ... Recent studies also show that nucleosome assembly protein 1 is also used to transport of H2A into the nucleus so it can wrap ...

*Cell (biology)

Cell nucleus: A cell's information center, the cell nucleus is the most conspicuous organelle found in a eukaryotic cell. It ... Structures outside the cell membrane. Many cells also have structures which exist wholly or partially outside the cell membrane ... In mammals, major cell types include skin cells, muscle cells, neurons, blood cells, fibroblasts, stem cells, and others. Cell ... Cell wall. Further information: Cell wall. Many types of prokaryotic and eukaryotic cells have a cell wall. The cell wall acts ...

*Caulleryellidae

Merogony occurs when nuclei are peripheral within the cell. The merozoites form a bouquet structure around the parent cell. The ... The parasites develop attached to the host cell by an epimerite. ...

*Chromatinas - Vikipedija

Arrangement of Chromosomes in Interphase Cell Nuclei, p. 223-234. In W. Hennig (ed.), Structure and Function of Eucaryotic ... Elements of chromatin structure: histones, nucleosomes, and fibres, p. 1-26. In S. C. R. Elgin (ed.), Chromatin structure and ... Cell 92:511-521.. *Gerasimova, T. I., and V. G. Corces. 2001. CHROMATIN INSULATORS AND BOUNDARIES: Effects on Transcription and ... Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases. Nature 437:1183-6. ...

*Ribosome Recycling Factor

Yeast mitochondrial RRF (mtRRF) is encoded by a gene in the cell nucleus. Loss of function of this gene leads to mitochondrial ... The crystal structure of RRF was first determined by X-ray diffraction in 1999. The most striking revelation was that RRF is a ... Selmer M, Al-Karadaghi S, Hirokawa G, Kaji A, Liljas A (December 1999). "Crystal structure of Thermotoga maritima ribosome ... Ribosome Recycling Factor (RRF) is a protein found in bacterial cells as well as eukaryotic organelles, specifically ...

*Eukaryotic transcription

A eukaryotic cell has a nucleus that separates the processes of transcription and translation. Eukaryotic transcription occurs ... The transcription of rRNA genes takes place in a specialised structure of the nucleus called the nucleolus, where the ... Eukaryotic transcription takes place in the nucleus of the cell and proceeds in three sequential stages: initiation, elongation ... The gene expression patterns that define cell identity are inherited through cell division. This process is called epigenetic ...

*Super-resolution microscopy

Two mouse cell nuclei in prophase. mouse cell in telophase One implementation of structured illumination is known as spatially ... Images of cell nuclei and mitotic stages recorded with 3D-SIM. Comparison confocal microscopy - 3D-SIM Cell nucleus in prophase ... Examples for this microscopy are shown under section Structured illumination microscopy (SIM), Images of cell nuclei and ... Huang, B.; S. Jones; B. Brandenburg; X. Zhuang (2008). "Whole cell 3D STORM reveals interactions between cellular structures ...

*Chromatin

Arrangement of Chromosomes in Interphase Cell Nuclei, p. 223-234. In W. Hennig (ed.), Structure and Function of Eucaryotic ... Chromatin is only found in eukaryotic cells (cells with defined nuclei). Prokaryotic cells have a different organization of ... Its structure depends on several factors. The overall structure depends on the stage of the cell cycle. During interphase, the ... "A bivalent chromatin structure marks key developmental genes in embryonic stem cells". Cell. 125 (2): 315-26. doi:10.1016/j. ...

*Spindle apparatus

The mitotic chromosome: structure and Mechanics. 2012. Genome Organization and Function in the Cell Nucleus. Wiley-VCH, Ch. 18 ... In cell biology, the spindle apparatus (or mitotic spindle) refers to the cytoskeletal structure of eukaryotic cells that forms ... Cell division orientation is of major importance for tissue architecture, cell fates and morphogenesis. Cells tend to divide ... E. Nogales; V. H. Ramey (1 November 2009). "Structure-function insights into the yeast Dam1 kinetochore complex". J Cell Sci. ...

*FAM149B1

The protein resides in the nucleus of the cell. The predicted secondary structure of the gene contains multiple alpha-helices, ... This protein is found mainly in the nucleus and plasma membrane of the cell. The DNAJc9 (DnaJ Heat Shock Protein Family (Hsp40 ... Cell, 162(2), 425-440. doi:10.1016/j.cell.2015.06.043 "ABHD8_HUMAN". UniProt. "METTL16 Gene". GeneCards. Archived from the ... protein is a methyltransferase found in the nucleus and cytosol of the cell. This protein was experimentally determined to ...

*Glossary of diabetes

DNA is stored chiefly in the cell nucleus of plant and animal (including human) cells. Small amounts of DNA are also kept in ... Circulation the structures and control mechanisms which manage blood circulation. It includes the heart, lungs, arteries, veins ... Delta cell A type of cell in the pancreas clumped with other cells (in the islets of Langerhans). Delta cells make somatostatin ... Some cells can store glucose internally (liver cells and muscle cells primarily), but others, most importantly, nerve cells, ...

*Staining

Hematoxylin stains the cell nucleus and other acidic structures (such as RNA-rich portions of the cytoplasm and the matrix of ... Methylene blue is used to stain animal cells, such as human cheek cells, to make their nuclei more observable. Also used to ... It may be used in living or fixed cells. DAPI-stained cells are especially appropriate for cell counting.[7] ... By causing certain cells or structures to take on contrasting colour(s), their form (morphology) or position within a cell or ...

*Avian orthoreovirus

... formed by fusion of cells or by division of nuclei.[4] Genome structure[edit]. The complete genome sequence of avian reovirus ... At this phase, clusters of IgM-positive, B-cells, T-cells, and plasma cells were also observed. During the chronic phase, a ... plasma cells and T-lymphocytes were the primary inflammatory cells present. During the acute-phase, CD8 cells were present in ... Apoptosis can also be induced in cells that are infected with UV-irradiated reovirus virions and cells infected with ribavirin- ...

*Metanephric adenoma

Cells are small with dark staining nuclei and inconspicuous nucleoli. Blastema is absent whereas calcospherites may be present ... They show a uniform architecture of closely packed acinar or tubular structures of mature and bland appearance with scanty ... tumour cells were reactive for Leu7 in 3 cases of 5, to vimentine in 4 of 6, to cytocheratin in 2 of 6, to epithelial membrane ... stated that genetic analysis of chromosome 7, 17, and Y may facilitate discrimination of MA from papillary renal cell carcinoma ...

*Cytoplasm

In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus. It comprises cytosol (the gel- ... the cell's internal sub-structures. All of the contents of the cells of prokaryotic organisms (such as bacteria, which lack a ... cell nucleus) are contained within the cytoplasm. Within the cells of eukaryotic organisms the contents of the cell nucleus are ... Organelles (literally "little organs"), are usually membrane-bound structures inside the cell that have specific functions. ...

*David L. Spector

Spector is a pioneer in unraveling our understanding of the inner workings of the cell nucleus. His early investigations ... centered on the unusual chromosome structure of dinoflagellates. Recent studies in his laboratory are focused on examining the ... Live Cell Imaging: A Laboratory Manual), and a treatise of The Nucleus, that are used in laboratories throughout the world. ... Live Cell Imaging: A Laboratory Manual (from CSHL Press) The Nucleus (Perspectives in Biology) (from CSHL Press). ...

*Interchromatin granule

Cell nucleus#Splicing speckles are subnuclear structures that are enriched in pre-messenger RNA splicing factors Berezney, ... An interchromatin granule is a cluster in the nucleus of a mammal cell which is enriched in pre-mRNA splicing factors. ... Interchromatin granules are located in the interchromatin regions of the mammalian Cell nuclei. They usually appear as ... Interchromatin granules are structures undergoing constant change, and their components exchange continuously with the ...

*Monomer

Nucleotides, monomers found in the cell nucleus, polymerize to form nucleic acids - DNA and RNA. Glucose monomers can ... thereby contributing constitutional units to the essential structure of a macromolecule. Amino acids are natural monomers that ... Molecular Biology of the Cell, 2008, Garland Science, ISBN 978-0-8153-4105-5. Ebuengan, Kaye. "Biomolecules: Classification and ...

*History of biology

... virus heredity and reproducing nucleoprotein cell structures outside the nucleus ("plasmagenes") complicated the accepted ... that chromosomes doubled in number just before the cell divided and a daughter cell was produced. Much of the research on cell ... proposed the distinction between somatic cells and germ cells (arguing that chromosome number must be halved for germ cells, a ... Robert Brown had described the nucleus in 1831, and by the end of the 19th century cytologists identified many of the key cell ...

*Catenin

Cell-cell adhesion complexes are required for simple epithelia in higher organisms to maintain structure, function and polarity ... 5-aminosalicylate (ASA) has been shown to reduce β-catenin and its localization to the nucleus in colon cancer cells isolated ... F9 embryonal carcinoma cells are similar to the P19 cells shown in Figure 1 and normally have cell-to-cell adhesion mediated by ... A tumor cell line with defective δ-catenin, low levels of E-cadherin and poor cell-to-cell adhesion could be restored to normal ...

*FAM71F2

... protein stays in the cytoplasm of cells, but may have localization in the nucleus and mitochondria. FAM71F2 is highly ... The secondary structure of FAM71F2 contains alpha helices and beta sheets. These structures are identified in the generated ... FAM71F2 protein expression has been detected in the cytoplasm of Leydig cells and in epididymis cells of the male testis and is ... "PELE Protein Structure Prediction". Biology Workbench. [permanent dead link] "UCSF Chimera Home Page". www.cgl.ucsf.edu. ...
Nuclear stress testing is currently the established non-invasive modality in detecting flow-obstructing coronary artery disease (CAD).. Recently, multi-detector CT (MDCT) has emerged as a new modality that offers a non-invasive means to directly visualize coronary anatomy and any CAD. Studies have shown that MDCT has excellent sensitivity and a high negative predictive value in detecting significant CAD.. The purpose of this study is to compare MDCT with nuclear stress testing for detecting CAD in previously undiagnosed patients. ...
Question - ECG shows inverted TWave, nuclear stress test done. Took medication for no reason. Side effects?. Ask a Doctor about when and why Nuclear stress test is advised, Ask an Internal Medicine Specialist
Nuclear stress testing is currently the established non-invasive modality in detecting flow-obstructing coronary artery disease (CAD).. Recently, multi-detector CT (MDCT) has emerged as a new modality that offers a non-invasive means to directly visualize coronary anatomy and any CAD. Studies have shown that MDCT has excellent sensitivity and a high negative predictive value in detecting significant CAD.. The purpose of this study is to compare MDCT with nuclear stress testing for detecting CAD in previously undiagnosed patients. ...
I am scheduled next week for a Nuclear Stress Test. I understand that this is a treadmill test, but will also include an IV and nuclear meds. I am not allowed to have any caffeine f, team9777board
I am a 61 year old male. I had triple bypass surgery in January 2007. In October I had a follow-up nuclear stress test (Stress QGS Tetrofosmin). I would like help interpreting the results of the...
Cardiolite is a nuclear radioactive isotope termed Technetium Tc99m Sestamibi. Cardiolite is injected through an IV and it travels in the bloodstream and through the coronary arteries until it is picked up by the heart muscle cells. The areas of the heart that have an adequate blood supply pick up the tracer right away and more completely. Areas that do not have adequate blood supply pick up the tracer very slowly or not at all.. Cardiolite gives off a small amount of radiation that is detected with a nuclear scanning camera. A computer processes the information and produces the images of the radioactivity distributed in the heart.. If an area receives less blood than the rest of the heart (because of a blocked or narrowed artery), it will pick up a lower level of radioactivity and will show up as a lighter area, called a "defect.". Cardiolite is injected while you are at rest and while your heart is under stress. Rest and stress images are taken to allow doctors to compare how much blood flows ...
In answer to some questions on your forum on how I found out that my heart was clear from plaque.:::: I had a Nuclear Stress test late in 2006 that showed my heart in real distress. The pictures that the test recorded, showed that my hearts arteries were nearly completely darkened in by plaque. This means that the arteries were all clogged, i.e., getting very little oxygen. My doctor said that I needed a bypass or a stent and must start on statin drugs immediately. I turned it all down. Needless to say he was really worried. I was very sick...couldnt walk far or fast, out of breath, blue feet...I felt like I was dying. Sooooo I started taking the Linus Pauling cure that I had been reading about... smile... I started feeling better within the first week. Each time I went to see my cardiologist he would comment on how well I was doing. My EKGs were even getting better. Then I took another Nuclear Stress test in late 2007, which showed my heart to be clear of plaque ...
The entire test will take approximately four to six hours, although you will be walking on the treadmill for approximately 10 minutes of that time. An IV will be started in your arm, and a small dose of radioactive isotope will be injected. After this injection, you will be asked to wait approximately 45 minutes to allow this material to be taken up by your heart cells. After the 45-minute wait time, you will lie on a scanning table and a special camera (gamma camera) will be positioned close to your chest, and you will be asked to lie still. The gamma camera takes pictures of your heart. This part of the test takes approximately 10-15 minutes. The stress laboratory is equipped with a Philips ADAC Cardio MD dual head camera.. After the image session, a specially-trained nurse will place electrodes on your chest, and wires will be attached to the electrodes so that the electrocardiogram (ECG) can be monitored continuously during the test. In men, limited shaving of the chest may be required to ...
Hello, I am 31 years old and have WPW, wich only acts up once in a while and almost never severe. I smoke cigars, drink beer, and have a desk job, I try to hit the gym at least a few time a week. I ...
this is for a cardiologist I reckon. best you seek an apt with your gp or cardiologist. sorry, others may know more, but I feel that this is for the medicos. people have different outcomes and responses, esp with testing. one persons results may be similar, but have different interpretation and meaning. take care ...
In recent years, by RNA sequencing and annotation by the GENECODE project, thousands of lncRNAs have been discovered, the functions of which have not been established. EGFR module/PDGFR module-based glioma classification forms a framework towards establishing molecular diagnostic tools and identifying novel therapeutic targets to combat gliomas (5). These results indicate that NEAT1 functions as an oncogene in glioblastoma. In this study, we compared the lncRNA profiles of glioma tissues from different grades using public data sets. We discovered that the lncRNA NEAT1 was driven by EGFR pathway activity. NEAT1 is an essential architectural component of paraspeckle nuclear bodies. The tumor anoxia microenvironment can activate NEAT1 and induce nuclear paraspeckle formation through HIF-2α, leading to breast cancer cell survival (10). In prostate cancer, NEAT1 has an oncogenic character and alters the epigenetic landscape of target gene promoters to favor transcription (37). NEAT1 showed the ...
Nuclear speckles are self-assembled organelles composed of RNAs and proteins. They are proposed to act as structural domains that control distinct steps in gene expression, including transcription, splicing, and mRNA export. Earlier studies identified differential localization of a few components within the speckles. It was speculated that the spatial organization of speckle components might contribute directly to the order of operations that coordinate distinct processes. By performing multi-color structured illumination microscopy, we characterized the multilayer organization of speckles at a higher resolution. SON and SC35 localize to the central region of the speckle, whereas MALAT1 and snRNAs are enriched towards the speckle periphery. Coarse-grained simulations indicate that the non-random organization arises due to the interplay between favorable, sequence-encoded intermolecular interactions of speckle-resident proteins and RNAs. Finally, we observe positive correlation between the total ...
Nuclear speckles are self-assembled organelles composed of RNAs and proteins. They are proposed to act as structural domains that control distinct steps in gene expression, including transcription, splicing, and mRNA export. Earlier studies identified differential localization of a few components within the speckles. It was speculated that the spatial organization of speckle components might contribute directly to the order of operations that coordinate distinct processes. By performing multi-color structured illumination microscopy, we characterized the multilayer organization of speckles at a higher resolution. SON and SC35 localize to the central region of the speckle, whereas MALAT1 and snRNAs are enriched towards the speckle periphery. Coarse-grained simulations indicate that the non-random organization arises due to the interplay between favorable, sequence-encoded intermolecular interactions of speckle-resident proteins and RNAs. Finally, we observe positive correlation between the total ...
A regular stress test helps to assess coronary blockages by monitoring EKG changes during treadmill exercise protocols. Although helpful in making a diagnosis, a regular stress test lacks the sensitivity and specificity of nuclear stress tests.. For more information on regular stress tests, please visit our Heart Center.. ...
I am doing well. I have a very strong fitness level, and continue on the protocol. I have seen another cardiologist who has kept me on Correg and Cozaar. He has given me NO limitations to physical activity, and was less concerned about the cardiomyopathy than the previous doctor. He felt that it may have been a temporary or transient condition. In fact, my first doctor gave me a nuclear stress test 12 months ago, and it showed a 61 EJF. That doc told me not to believe that number, and to believe the 45-50 shown from the echo in May of this year. It has been confusing, however, the aortic regurgitation is what he is monitoring now for change. I have still continued your protocol, is this what you recommend based on this latest information ...
The usual testing for blocked arteries is the heart cath, as it shows complete detail over the other. There is a possibility there was blockage in the other artery but wasnt enough to warrant intervention. A friend of ours flunked her nuclear stress test & was sent to the hospital immediately for a cath. She had severe blockage & underwent bypass surgery as the drs were in fear of her having a heart attack. She swears to this day she had no symptoms, so this came as a huge shock ...
Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Milunski on lexiscan mibi stress test: Nuclear stress test are done to evaluate coronary circulation/ blockages/CAD. As lagniappe they provide info re LV function. However, there are less expensive and invasive test that evaluate LV function just as well or better, like echocardiography
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Cell Nucleus Structures definition. define Cell Nucleus Structures. Explain Cell Nucleus Structures. What is Cell Nucleus Structures? Cell Nucleus Structures FAQ.
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Myocardial perfusion is an imaging test. Its also called a nuclear stress test. It is done to show how well blood flows through the heart muscle. It also shows how well the heart muscle is pumping. For example, after a heart attack, it may be done to find areas of damaged heart muscle. This test may be done during rest and while you exercise.
ECG electrodes will be attached to your chest. The electrodes are small, sticky patches with wires. Your resting blood pressure and ECG readings will be taken.. The cardiac stress test is done on a treadmill or a stationary bike. You will slowly start walking or riding. At regular intervals, the speed and elevation will be increased. Your ECG, blood pressure, heart rate, and symptoms will be closely monitored.. The test may be stopped early if you feel extremely tired, get chest pain, have trouble breathing, or if you have any symptoms that suggest heart problems. Significant changes in the ECG will also stop the test. After exercise is complete, your blood pressure, heart rate, and ECG will be monitored until levels return to normal.. A blood flow imaging exam may also be ordered. This is called a nuclear stress test. A small amount of radioactive chemical will be injected into a vein when you are exercising at your peak. Scans will be taken while you lie in different positions under a special ...
While regadenoson has become the vasodilator stress agent of choice and has streamlined and simplified stress protocols in many nuclear stress laboratories, the adverse effect of dyspnea is still experienced by many patients, and even more so by those with COPD and asthma. While patients and practitioners should anticipate this symptom, several studies have shown that the subjective experience of dyspnea is not correlated with and is not caused by bronchoconstriction. Available data from observational studies as well as controlled clinical trials, as summarized in Table 1, indicate that the use of regadenoson in patients with mild to moderate asthma and mild to moderate COPD is safe. The current data in patients with severe COPD, while limited, are reassuring and indicate that regadenoson is probably safe, particularly in those with stable lung disease. Clinical data are limited in COPD patients who require 24-hour/day home oxygen administration, have previously been intubated for respiratory ...
Adenosine myoview stress test - How much does adenosine nuclear stress test cost? Adenosine stress $$$. The cost depends on where you live and whether test is being done in a hospital facility or cardiologist office the cost can vary from 800$ to 2000$.
Scientists at the US Department of Energys Pacific Northwest National Laboratory have performed first-of-a-kind, high-resolution examinations of cracks in stainless steel core components from commercial nuclear reactors, dispelling many of the traditionally held beliefs about how cracks develop and spread.. According to the DOE, it has been long held that cracks in nuclear reactor components are the result of alloy embrittlement or local changes to the water environment caused by radiation. With the use of analytical electron microscopy and a new approach to access buried corrosion interfaces for study, however, Larry Thomas and Steve Bruemmer have discovered that the crack advance is promoted by radiation-enhanced, corrosion-induced material changes ahead of the tip of the crack.. While cracking of metal components inside nuclear reactors has been a continuing problem over many years, the ability to directly evaluate cracking mechanisms has been limited. Most research has been performed ...
Choudhry H, Albukhari A, Morotti M, Haider S, Moralli D, Smythies J, Schödel J, Green CM, Camps C, Buffa F, Ratcliffe P, Ragoussis J, Harris AL, Mole DR et al. 2015. Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival. Oncogene, 34 (34), pp. 4482-4490. , Show Abstract , Read more Activation of cellular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is common in many types of cancer, and generally confers a poor prognosis. Known to induce many hundreds of protein-coding genes, HIF has also recently been shown to be a key regulator of the non-coding transcriptional response. Here, we show that NEAT1 long non-coding RNA (lncRNA) is a direct transcriptional target of HIF in many breast cancer cell lines and in solid tumors. Unlike previously described lncRNAs, NEAT1 is regulated principally by HIF-2 rather than by HIF-1. NEAT1 is a nuclear lncRNA that is an essential structural ...
Antisens Protein of HTLV-2 (APH-2) was described in 2009. APH-2 mRNA is expressed in vivo in most HTLV-2 carriers. In recent years, several laboratories have searched for similarities and/or differences between APH-2 and the antisens protein of HTLV-1, HBZ. Similarly to HBZ, APH-2 negatively regulates HTLV-2 transcription. However, it does not promote cell proliferation. In vivo, APH-2 localizes in discrete nuclear domains distinct from nucleoli. We therefore characterized APH-2 subcellular localization, in order to decipher the determinants of such localization and to correlate it or not with APH-2 functions. We first identify APH-2-containing nuclear domains as PML nuclear bodies (PML-NB). PML-NB are modulators of a number of cellular processes ranging from transcription regulation to cell proliferation and death. We show that both an in silico-identified nuclear localization signal and the carboxy-terminal LXXLL motif contribute to APH-2 targeting to PML-NB. Covalent modification of APH-2 by ...
Dr Wes--I consider myself fortunate, as a 56 yr male paroxysmal ATF patient (primarily nocturnal & highly symptomatic; prevented me from sleeping), to have had good luck with flecainide, 100mg daily. It took me a while to determine that there are 2 types of cardiologists: plumbers and electricians. Once I determined that I needed what I found out was your specialty, a Cardiac Electrophysiologist, and once my doctor got a good capture on a Holter Monitor, he prescribed the flecainide after the nuclear stress test and an echocardiogram, and I never looked back. Five years later, and a second stress test, no problems. Hopefully the medication, which is thankfully generic, will continue to work well. For me, at least, its a triumph of modern pharmacology. I enjoy your commentary on this blog; youve referred me to a number of informative sources that have helped educate this engineer as to what ATF is all about. Keep up the great work! ...
Nuclear stress test utilizes nuclear isotope (most commonly Cardiolite) which traces blood flow to the heart. This nuclear tracer in the blood is taken up by heart muscle in proportion to coronary blood flow, i.e., normal uptake if the flow is intact and less uptake if the flow is reduced due to coronary blockage. This blood flow pattern is shown by nuclear camera which scans the small amount of radioactivity emitted by the isotope taken up by heart tissue. Hence the test is primarily designed to detect signs of coronary artery disease. This isotope is well-tolerated by most and is cleared from the body in 24 to 36 hours.. This is carried out in two parts: stress images and resting images. The stress part can be done with treadmill stress test or "chemical" stress test (most commonly Lexiscan or Persantine) if you cannot physically exercise. At peak exercise or following injection of Lexiscan, Cardiolite is injected and the patient is scanned under the nuclear camera. The resting images are also ...
Cells expressing fluorescent tagged splicing factors. Experiments were performed in the Michael J Hendzel Laboratory in the Department of Oncology at the University of Alberta ...
An overview of the mammalian heat shock factor (HSF) family members and their biological functions. HSFs contribute to multiple normal physiological processes and pathologies through direct regulation of their target genes. The HSF target genes that have been identified in vivo are shown. HSF1 was originally recognized as the principal stress-responsive regulator of the heat shock response, but now HSF2 is known to modulate HSF1-mediated expression of heat shock protein (HSP) genes through heterocomplex formation. On heat shock, HSF1 and HSF2 accumulate into nuclear stress bodies (NSBs), where they bind to satellite III repeats. HSF1 is also a regulator of immune responses and cancer. So far, the regulation of HSP genes in ageing has most intensively been examined in Caenorhabditis elegans. Both HSF1 and HSF2 have been ascribed regulatory functions in several developmental processes, such as oogenesis, spermatogenesis and corticogenesis. HSF4 is involved in the development of different sensory ...
at rest.. A recent study shows that patients with more epicardial adipose tissue, that is, a layer of fat around the heart, tend to have the types of atherosclerotic plaques that cardiologists deem most dangerous. These plaques fall into the non-calcified category.. Fortunately, this type of heart fat tissue can be measured by imaging techniques such as CT or MRI. Imaging this tissue provides the cardiologist with more information than standard diagnostic techniques, such as coronary calcium scoring, according to recent research by Emory cardiologists.. "This information may be used as a gatekeeper in that it could help a cardiologist decide whether a patient should go on to have a nuclear stress test," says Emory radiologist Paolo Raggi.. Heres why. Calcium, says Raggi, tends to build up in atherosclerotic plaques. And although the hearts overall coronary calcium burden is a good predictor of heart disease, calcium in an individual plaque doesnt necessarily spell imminent trouble, he ...
In this multicenter study of a large contemporary population of predominantly low- to intermediate-risk stable outpatients with symptoms suggestive of CAD, women and men differed substantially in their clinical presentation, diagnostic evaluation, and noninvasive testing results. Women had a higher prevalence of traditional cardiac risk factors, but they were more likely to be characterized as low risk by providers and existing risk scores. In addition, women were more likely to be referred for imaging stress tests compared with men, particularly nuclear stress testing, but they were less likely to have a positive test. Finally, predictors of test positivity differed between the sexes. To our knowledge, this is the largest contemporary description of sex-based differences in presentation, evaluation, and noninvasive testing results in a large, stable outpatient population evaluated for symptoms of suspected CAD.. A number of previous studies have compared differences in demographics, risk factor ...
The curcumin supplementation has shown an increase in circulating nitric oxide, ranging up to 40% in just four weeks. These potential cardiovascular benefits are too important to be ignored, especially if you have a high risk of complications. There is just one problem with curcumin humans are very bad at absorbing it. For all the great benefits to health, it is essential to consume curcumin with an enhancer such as black pepper.. * I followed that with a positive stress test, which is not what you want. Since I do not smoke and have no chest pain resting or exercising, my doctor has submitted me to a nuclear stress test, where they inject a tracer into blood and 12 minutes on the treadmill. The technician who administered the test saw nothing to worry about from the ECG during the test. I still have to wait for the heart scans taken during the test.. * It has been proven that consuming a lot of fiber helps to prevent high blood pressure, and can also control your appetite and avoid the roller ...
Nuclear Stress TestS June 2012 greenpeace.eu Introduction 4 Main shortcomings 6 of the EU stress tests Critical review of selected 9 nuclear power plants Spain: Almaraz 9 Belgium: Doel 9 Belgium: Tihange:
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Wilshire Cardiology Group is equipped with state-of-the-art cardiac diagnostic technologies in order to provide the best medical care to the patients. The staff is regularly updated and trained in the latest developments in cardiac care. The services rendered by WCG include Cardiac Cathetherization/Angiogram, Cardiac Evaluation, Carotid Duplex Scan, Echocardiogram, EECP, Electrocardiogram (EKG), Electrophysiology Study, Exercise Treadmill Test (ETT/Stress Test), Holter Monitor Study, Event Monitor, Nuclear Stress Test, and Stent. ...
Proteins of the Drosophila behavior/human splicing (DBHS) family include mammalian SFPQ (PSF), NONO (p54nrb), PSPC1, and invertebrate NONA and Hrp65. DBHS proteins are predominately nuclear, and are involved in transcriptional and posttranscriptional gene regulatory functions as well as DNA repair. …
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Introduction: Diagnostic testing may represent a "teachable moment" for patients newly presenting with symptoms suggestive of CAD and requiring further evaluation, and may influence risk factor management, independent of test results. However, little is known about changes in medications and lifestyle after anatomical versus functional testing.. Hypothesis: Patients assigned to coronary CTA will report greater use of preventive medications and lifestyle practices.. Methods: We randomly assigned 10,003 symptomatic patients (53% women; mean age 61 yrs) to anatomical testing with CTA or functional testing (exercise ECG, nuclear stress, or stress echocardiography). We assessed use of preventive medications (aspirin, statin, beta blocker, and ACEi/ARB) and lifestyle practices (heart healthy diet, regular exercise, smoking, and obese/overweight status [BMI,25]) at 60 days. Chi-square tests assessed between-group changes (initiation or discontinuation). Multivariable logistic regression models assessed ...
Lexington Medical Center offers comprehensive cardiovascular care. Affiliated with Duke Medicine, Lexington Medical Heart Center offers a full range of cardiac services including open heart surgery, catheterizations and angioplasty, using state-of-the-art technology with a team of highly-skilled clinicians.. Sumter Cardiology is a Lexington Medical Center physician practice. It offers services including cardiac consultation and evaluation, nuclear stress testing, echocardiograms, heart catheterizations, electrophysiological testing, pacemaker and defibrillator services, exercise and pharmacologic stress testing, vascular studies and heart monitoring. For information on future patient education series events in Sumter, visit Sumter Cardiologys website at www.sumtercardiology.com.. February is Heart Disease Awareness Month. Learn about Lexington Medical Centers "Take 5 for Heart Health" campaign at lexmed.com/take5.. ...
Gene Information This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins such as apoptosis antigen Fas centromere protein C and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications including sumoylation phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq Nov 2008]. ...
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Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;64(24):e139-e228. PMID: 25260718 www.ncbi.nlm.nih.gov/pubmed/25260718. Fihn SD, Blankenship JC, Alexander KP, et al. 2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2014;64(18):1929-1949. PMID: 25077860 www.ncbi.nlm.nih.gov/pubmed/25077860. Kramer CM, Beller GA, Hagspiel KD. Noninvasive cardiac imaging. In: Goldman ...
Jan Slater, CEO, OSU Medical Center, said OSU Mobile Cardiology enables Oklahomans to receive the testing they need in their home communities, which saves patients valuable time.. "OSU Mobile Cardiology offers critical diagnostic testing on site, at a physicians office, hospital or health-care location," Slater said. "The testing is the same as what you find in a high-level cardiology department like OSU Medical Center.". OSU Mobile Cardiology testing includes abdominal ultrasound, carotid duplex ultrasound, echocardiogram exercise stress test, exercise stress test, lower extremity duplex ultrasound, nuclear stress testing, nuclear medicine diagnostic studies, stress echocardiography and venous Doppler ultrasound ...
A nuclear cardiac imaging study is a non-invasive procedure that evaluates blood flow to your heart muscle. This procedure will last approximately six hours and involves testing in multiple phases.. During stress testing, you will walk on a treadmill (or are given medicine if you are unable to exercise) to make your heart work harder and beat faster. You will be connected to EKG and blood pressure monitors during this test so doctors can evaluate how your heart performs during exercise.. During a nuclear stress test, radioactive tracer is injected into your bloodstream after you reach your maximum level of exercise. You then lie down on a special table under a camera that shows the flow of blood through your heart and arteries by tracing the nuclear material in your blood. This picture of your heart when it is "stressed" is then compared with a picture taken of your heart at its resting rate.. A stress test lets the doctor see how your heart responds to exercise, and also what level of exercise ...
As a general cardiologist, I care for patients diagnosed with a spectrum of cardiovascular diseases, including acute and chronic manifestations of coronary artery disease, congestive heart failure, cardiomyopathies, valvular disorders, arrhythmias and aortic and pericardial diseases. I have expertise in the role of echocardiography and nuclear cardiac imaging for the evaluation of cardiac disorders, including transesophageal echocardiography (TEE), nuclear stress testing (myocardial perfusion imaging), viability imaging and multiple-gated acquisition scan (MUGA) studies for evaluation of cardiac function. I supervise and interpret these studies at both the Buffalo General Medical Center (BGMC) and Gates Vascular Institute (GVI) and in the outpatient setting. I also perform electrical cardioversions to manage arrhythmias and interpret electrocardiograms (EKGs) for BGMC, and I provide consultative services there as well. I care for inpatients in the critical care and cardiac monitoring units ...
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Neurodegenerative diseases are among the most common causes of disability worldwide. Although neurodegenerative diseases are heterogeneous in both their clinical features and the underlying physiology, they are all characterised by progressive loss of specific neuronal populations. Recent experiment …
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Akuter Einfluss subletaler Stressdosen führte zu Wachstumsstopp, seneszenzähnlichen morphologischen Veränderungen und erhöhter SA-ß-Galactosidaseexpression. Chronischer niedrig dosierter oxidativer Stress hatte keine relevanten Auswirkungen auf Morphologie und Proliferationsverhalten. Chronischer Stresseinfluss hatte jedoch einen signifikant erhöhten Telomerverlust zur Folge. Nach akuter oxidativer Stresseinwirkung zeigte sich ein signifikanter Anstieg der p21 Expression. Die TRF1 Expression war signifikant erniedrigt, während TRF2 leicht vermehrt exprimiert wurde. Die Expression von SIRT1 und XRCC5 war nach akuter oxidativer Stresseinwirkung signifikant erhöht. Bei präseneszenten Zellen fiel der Expressionsanstieg sogar noch deutlicher aus als bei jungen Zellen. Im Vergleich zu Fibroblasten und Chondrozyten zeigten MSCs im Hinblick auf Proliferationsverhalten, Morphologie, Telomerbiologie und Genexpression eine erhöhte Widerstandsfähigkeit gegenüber oxidativem Stress ...
Eine Sammlung von wissenschaftlichen Publikationen, welche in der aktuellen Gentechdebatte eine Rolle spielen: Aufregende Entwicklungen, Sicherheitsforschung und kontroverse Veröffentlichungen. Dieser Teil ist leider nur auf englisch erhältlich. Viele der Publikationen haben jedoch eine einfach verständliche Zusammenfassung der wichtigsten Resultate ...
Eine Sammlung von wissenschaftlichen Publikationen, welche in der aktuellen Gentechdebatte eine Rolle spielen: Aufregende Entwicklungen, Sicherheitsforschung und kontroverse Veröffentlichungen. Dieser Teil ist leider nur auf englisch erhältlich. Viele der Publikationen haben jedoch eine einfach verständliche Zusammenfassung der wichtigsten Resultate ...
Zum Drucken pdf nehmen, zum Ändern/Übersetzen ist die OpenOffice-Datei (odg) da.. Beim Herumdingsln im OpenOffice ein Achtung: Ihr werdets wahrscheinlich andere Schriften haben, also müsst ihr euch dann leider selber welche aussuchen. Die Schriften wurden so gewählt, dass jede Platz-Gruppe einen eigenen Schriftstil erhält ...
Acute promyelocytic leukemia (APL) is characterised by the t(15;17)(q22;q21) leading to fusion of PML to the gene encoding the myeloid transcription factor Retinoic Acid Receptor α (RARα). Chromosomal translocations such as the t(15;17) are considered to be initiating events in leukemogenesis; however, sequencing of APL genomes has provided further evidence that the PML-RARα fusion is insufficient to induce leukemia, which depends upon the acquisition of cooperating mutations. The PML-RARα oncoprotein exerts a profound effect on nuclear architecture, disrupting multiprotein structures known as PML nuclear bodies (NBs). The function of these structures remains an enigma; however, their disruption in PML-RARα+ APL and acute lymphoblastic leukemia with the t(9;15)(p13;q24)/PAX5-PML fusion is associated with delocalisation of a number of component proteins including PML, which have been implicated in growth control and neoplastic transformation. It is now established that the PML moiety ...
If you have a question about this talk, please contact Francesca Chadha-Day.. A robust and detailed knowledge of the proton subnuclear structure is a crucial input at the Large Hadron Collider (LHC). The uncertainty on the Parton Distribution Functions (PDFs) - the functions that parametrise protons in terms of their elementary constituents, quarks and gluons - often represents a limiting factor in the accuracy of theoretical predictions at hadron colliders. At the same time the precise measurements taken at the LHC give a powerful insight on the proton. I will give an overview of the theoretical aspects behind PDFs determination and on the state of the art of modern PDFs fits. I will then mention the new exciting challenges that the precision frontier is presenting, such as the interplay between the proton structure and the hunt for new physics beyond the Standard Model.. This talk is part of the Wednesday HEP-GR Colloquium series.. ...
In this study, we show that degrasyn induces c-Myc down-regulation is proteasomal-dependently mediated through a novel region not previously associated with its proteasomal degradation. c-Myc protein stability is regulated by a NH2-terminal "degron" that signals c-Myc ubiquitination and a COOH-terminal "stabilon" that stabilizes c-Myc by enabling it to associate with the POZ domain protein Miz or to be sequestered in a subnuclear compartment in which it is stable ( 12, 17). It was initially assumed that sequences located between the degron and stabilon were dispensable for all aspects of c-Myc function ( 39, 40). However, the region of c-Myc between amino acid residues 190 and 210 (the D element) was recently found important for initiating the degradation of c-Myc at a post-ubiquitination stage ( 20). In addition, phosphorylation of the Thr358, Ser373, and Thr400 amino acid residues by PAK2 has been shown to reduce c-Myc interaction with Max and to induce degradation of c-Myc through an unknown ...
In the technique, each complex in the nucleus is given a different molecular barcode, with all of the molecules within a single complex receiving the same barcode. Then, the complexes can be broken open and the molecules analyzed. This way, scientists can determine if two or more molecules were interacting, depending on whether they had the same barcode.. Led by graduate student Sofia Quinodoz, the team used SPRITE to discover that genes across different chromosomes (large folded structures of DNA) cluster together around specific nuclear bodies. Specifically, inactive genes--those that are turned off--across different chromosomes cluster together around a particular nuclear body called the nucleolus, which contains repressive proteins on DNA that keep genes turned off. Conversely, active genes grouped about another kind of nuclear body called the nuclear speckle, contain molecules that help turn the genes on and make them into proteins.. "With SPRITE, we were able to see thousands of ...
In der Vergangenheit wurden solche Rückstände in Unkenntnis, zum Teil auch unter Missachtung der darin enthaltenen erhöhten Radioaktivität, auf Halden und in Rückstandsbecken deponiert oder auch weiter verwertet. Durch Sickerwasser, aber auch durch Unfälle, wie zum Beispiel bei Dammbrüchen von Rückstandsbecken, können Radionuklide in gelöster Form oder feste Rückstände freigesetzt und im ungünstigsten Fall in Flusssedimenten oder Auenböden abgelagert worden sein. Teilweise wurden ehemalige Industriestandorte mit radioaktiven Hinterlassenschaften neu bebaut. In Abhängigkeit von den Standort- und Nutzungsbedingungen können als Folge solcher Hinterlassenschaften im Einzelfall Strahlenexpositionen entstehen, die nachträglich Schutzmaßnahmen erfordern.. Für den Bereich der radioaktiven Hinterlassenschaften gibt es - mit Ausnahme der Regelungen zur Sanierung der Hinterlassenschaften des ostdeutschen Uranerzbergbaus - noch keine hinreichenden Regelungen.. ...
Use Bio-Rads PrimePCR assays, controls, templates for your target gene. Every primer pair is optimized, experimentally validated, and performance guaranteed.
Phytogene Futtermittelzusätze (PFAs) verbessern wirksam den antioxidativen Status der Tiere. Dies wurde durch den Nachweis eines erhöhten antioxidativen Levels im Blutplasma, Fleisch und Gastrointestinaltrakt bestätigt.
Das Neue Museum birgt nicht nur zwei interessante archäologische Sammlungen zur Vor-und Frühgeschichte und zum Alten Ägypten, sondern ist selbst ein Kulturdenkmal ersten Ranges. Die Führung stellt fünf Highlights der Sammlungen und der Architektur vor.. Begrenzte Teilnehmerzahl. Teilnahmekarten sind online buchbar und an der Museumskasse erhältlich. ...
Das Neue Museum birgt nicht nur zwei interessante archäologische Sammlungen zur Vor-und Frühgeschichte und zum Alten Ägypten, sondern ist selbst ein Kulturdenkmal ersten Ranges. Die Führung stellt fünf Highlights der Sammlungen und der Architektur vor.. Begrenzte Teilnehmerzahl. Teilnahmekarten sind online buchbar und an der Museumskasse erhältlich. ...
Background: Rotavirus infection is one of the most common gastroenteritis in the world, and a million cases are registered to enter hospital every year. Promyelocytic leukemia proteins (PMLs) are IFN-up-regulated proteins, and one of their critical functions is working as antiviral proteins. Recently, promyelocytic leukemia isoform II (PML-II) has been depicted ...
Dentifrice speckles of substantially uniform shape and size are made by agitating the material of such speckles (binder plus dentifrice component) in a liquid dispersing medium at temperature at which the binder is liquid but undissolved and unemulsified in the dispersing medium, and cooling the dispersion to a temperature below the solidification point of the speckling material so as to solidify it into speckles of desired size. Such speckles may be separated from the dispersing medium or may remain in it and be utilized with it. Preferably the speckles are incorporated in dentifrices and contain dentifrice components desirably maintained separate from the rest of the dentifrice. Also included within the invention described are the speckles and dentifrices containing them.
DataMed is a prototype biomedical data search engine. Its goal is to discover data sets across data repositories or data aggregators. In the future it will allow searching outside these boundaries. DataMed supports the NIH-endorsed FAIR principles of Findability, Accessibility, Interoperability and Reusability of datasets with current functionality assisting in finding datasets and providing access information about them.
Researchers have published a cellular delivery method of nanoparticles called quantum dots which could be used as molecular probes for simultaneous imaging and manipulation of single biomolecules in the nucleus and for observation of subnuclear structures and events in the Oct. 4 edition of Small.
In the theory of viral eukaryogenesis I propose here, the eukaryotic nucleus evolved from a complex DNA virus. It is proposed that the virus established a persistent presence in the cytoplasm of a met
Cookies sind kleine Datensätze, die beim Aufruf von Webseiten erzeugt und auf dem Rechner des jeweiligen Nutzers abgelegt werden. Das Cookie verfügt über eine eindeutige ID, die Ihrem Gerät zugewiesen ist, enthält jedoch keine Ihrer persönlichen Daten wie den Namen oder die E-Mail-Adresse.
Ist es ein großes grünes Gerät? Ist es ein Joint in Flugzeuggröße? Es ist der unglaubliche Knospenmann. Hier um die Welt zu retten oder wenigstens, um sie zu machen. Schwarzes Qualitäts-T-Shirt, erhältlich in M, L und XL. ...
Achtung: Diese Waffe ist ab 18 Jahren erhältlich. Infos zum Waffengesetz finden Sie hier: Waffengesetz System: Spring Kaliber: 6mm Material: Metall
SALFORD City Reds chairman John Wilkinson will be keeping a close watch on Lee Jewitt as the new Super League season unfolds. It is an important year for Jewitt, an Oldham lad whose potential and raw boned aggression first surfaced as a junior playing for Wigan.
Previously, weve shown that paraspeckle protein 1 (PSPC1), a protein element of paraspeckles that was involved with cisplatin-induced DNA damage response (DDR), probably functions at the G1/S checkpoint. observations suggest an important role for PSPC1 in MMS-induced DDR, and in particular, depletion of PSPC1 can enhance MMS-induced apoptosis through mitotic catastrophe. Introduction Mitotic catastrophe was first described in as a temperature-sensitive lethal phenotype that was observed in some mutant strains and associated with gross abnormalities of chromosome segregation [1, 2]. Similarly, mammalian cell mitotic catastrophe had been described as the failure to undergo complete mitosis after DNA damage (coupled to defective checkpoints). After several cell cycles, this situation would lead to tetraploidy or endopolyploidy with extensive DNA damage, perhaps followed by the selection of apoptosis-resistant cells that would ultimately survive after endo reduplication [3, 4]. Nowadays, the term ...
Product Name: Rabbit anti-human promyelocytic leukemia protein (PML) ring finger domain pAbCollection: AntibodySub Category: Polyclonal AntibodyImmunogen:
PURPOSE: Metarrestin is a first-in-class small molecule clinical candidate capable of disrupting the perinucleolar compartment, a subnuclear structure unique to metastatic cancer cells. This study aims to define the pharmacokinetic (PK) profile of metarrestin and the pharmacokinetic/pharmacodynamic relationship of metarrestin-regulated markers. METHODS: PK studies included the administration of single or multiple dose of metarrestin at 3, 10, or 25 mg/kg via intravenous (IV) injection, gavage (PO) or with chow to wild-type C57BL/6 mice and KPC mice bearing autochthonous pancreatic tumors. Metarrestin concentrations were analyzed by UPLC-MS/MS. Pharmacodynamic assays included mRNA expression profiling by RNA-seq and qRT-PCR for KPC mice. RESULTS: Metarrestin had a moderate plasma clearance of 48 mL/min/kg and a large volume of distribution of 17 L/kg at 3 mg/kg IV in C57BL/6 mice. The oral bioavailability after single-dose (SD) treatment was , 80%. In KPC mice treated with SD 25 mg/kg PO, plasma ...
Mouse monoclonal antibody raised against a full-length recombinant ERH. ERH (AAH14301, 1 a.a. ~ 104 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (H00002079-M07A) - Products - Abnova
Hello, Neat Video does a great job for me even using the auto profile and getting only 67%. I have some video where I deliberately filmed a piece of white foam board at about 4 feet away to help me get a noise profile for a particular Civic Center venue. When I applied Neat Video filter to my clip, I was able to get a 256 x 122 sample size yet no profile was generated. When I auto profile the sample Neat Video tells me the sample size is to small. Im working in FCP 7 and I dont understand why, when I have a sample size up to and over 122 x 122, that Neat Video will not create a profile for me. Like I said the 67% profile that auto profile is creating does a great job, I just dont understand the problem when I know my sample size is large enough ...
ProntoSIL C8 SH-ist eine klassische C8-Phase. Sie ist voll basendeaktiviert (Endcapping) und weist daher ein sehr gutes Basenverhalten auf. Wegen ihrer einzigartigen Bonding Technologie zeigt sie eine erhöhte Selektivität bei der Trennung räumlicher Strukturen (shape selectivity), sowie eine erhöhte Stabilität in sauren Eluenten bis pH 1. Die ProntoSIL C8 SH-Phase ist mit verschiedenen Porenweiten und in verschiedenen Partikelgrößen erhältlich. Das 300 Å Material zeigt hervorragende Eigenschaften bei der Trennung von großen Biomolekülen, wie Proteinen und Peptiden. Die 5 µm-Phase ist auch in 60 Å verfügbar ...
FBXO27兔多克隆抗体(ab45379)可与人样本反应并经WB实验严格验证,被1篇文献引用。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
Neatorama is the neat side of the Web. We bring you the neatest, weirdest, and most wonderful stuff from all over the Web every day. Come back often, mmkay? ...
Neatorama is the neat side of the Web. We bring you the neatest, weirdest, and most wonderful stuff from all over the Web every day. Come back often, mmkay? ...

Cell Biology: Structure and Functions of the Nucleus | Biology | MIT OpenCourseWareCell Biology: Structure and Functions of the Nucleus | Biology | MIT OpenCourseWare

Lectures and class discussions will cover the background and fundamental findings in a particular area of nuclear cell biology ... The goal of this course is to teach both the fundamentals of nuclear cell biology as well as the methodological and ... An illustration showing an example of the structure and organization of DNA in the nucleus of a human cell. (Image couresty of ... 7.60 Cell Biology: Structure and Functions of the Nucleus. Spring 2010. Massachusetts Institute of Technology: MIT ...
more infohttps://ocw.mit.edu/courses/biology/7-60-cell-biology-structure-and-functions-of-the-nucleus-spring-2010/

The three-dimensional architecture of the notochordal nucleus pulposus: novel observations on cell structures in the canine...The three-dimensional architecture of the notochordal nucleus pulposus: novel observations on cell structures in the canine...

Cells from (A) grade I and (B) grade III nuclei pulposi. Green: actin; red: cell nuclei. Note the large inclusions in the cells ... cell nuclei). Connexin-43 was scattered over the entire cell surface, with a concentration in the vicinity of cell-cell ... very few cells could be found in the grade III nucleus (arrows, D). Cell clusters in grade I nuclei appeared to be surrounded ... with a loss of both cell clusters and physaliferous cells during ageing. These observations demonstrate unique cell structures ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/12713268?dopt=Abstract

Cell Nucleus Biogenesis, Structure and Function - Reviews in Cell Biology and Molecular Medicine - Jackson - Wiley Online...Cell Nucleus Biogenesis, Structure and Function - Reviews in Cell Biology and Molecular Medicine - Jackson - Wiley Online...

Cell Nucleus Biogenesis, Structure and Function. Reviews in Cell Biology and Molecular Medicine. . ... The Cell Nucleus: Biogenesis, Structure, and Function. Dean A. Jackson. Version of Record online: 10 OCT 2011 , DOI: 10.1002/ ... Cell Nucleus Biogenesis, Structure and Function. Dean A. Jackson. Version of Record online: 15 SEP 2006 , DOI: 10.1002/ ...
more infohttp://onlinelibrary.wiley.com/doi/10.1002/3527600906.mcb.200300097/otherversions

MIT OpenCourseWare | Biology | 7.60 Cell Biology: Structure and Functions of the Nucleus, Spring 2006 | HomeMIT OpenCourseWare | Biology | 7.60 Cell Biology: Structure and Functions of the Nucleus, Spring 2006 | Home

Topics include Eukaryotic genome structure, function, and expression, processing of RNA, and regulation of the cell cycle. The ... Lectures cover broad topic areas in nuclear cell biology and class discussions focus on representative papers recently ... This course covers the fundamentals of nuclear cell biology as well as the methodological and experimental approaches upon ... techniques and logic used to address important problems in nuclear cell biology is emphasized. ...
more infohttp://dspace.mit.edu/bitstream/handle/1721.1/71859/7-60-spring-2006/contents/index.htm?sequence=3

psychexam1 - Psychology Exam 1 Nucleus biological control center for the cell Chromosomes structures in nucleus that contain...psychexam1 - Psychology Exam 1 Nucleus biological control center for the cell Chromosomes structures in nucleus that contain...

... biological control center for the cell Chromosomes- structures in nucleus that contain genes, unit of ... Psychology Exam 1 Nucleus - biological control center for the cell Chromosomes - structures in nucleus that contain genes, unit ... The Structure of the Neuron Playing the piano driving a car or hitting a tennis ...
more infohttps://www.coursehero.com/file/13462911/psychexam1/

A*STAR Scientists Make Discovery of Cell Nucleus Structure Crucial to Understanding DiseasesA*STAR Scientists Make Discovery of Cell Nucleus Structure Crucial to Understanding Diseases

... News Feb 08, 2013 ... The nucleus - the brain of the cell - carries all the information, in the form of chromatin necessary to help a cell grow, ... scientists were puzzled by why heterochromatin clustered at the edge of the nucleus and how it was relevant to normal cell ... A gene which produces a protein that transports drugs in and out of cells may explain why some women treated with chemo have ...
more infohttps://www.technologynetworks.com/genomics/news/astar-scientists-make-discovery-of-cell-nucleus-structure-crucial-to-understanding-diseases-187232

Cell Nucleus Structures - Medical DictionaryCell Nucleus Structures - Medical Dictionary

define Cell Nucleus Structures. Explain Cell Nucleus Structures. What is Cell Nucleus Structures? Cell Nucleus Structures FAQ. ... Cell Nucleus Structures. Medical Dictionary -> Cell Nucleus Structures. Search: Cell Nucleus Structures. Structures that are ... part of or contained in the CELL NUCLEUS.. © MedicalDictionaryweb.com 2012 , Contact Us , Terms of Use , Teeth Whitening , Low ...
more infohttp://medicaldictionaryweb.com/Cell+Nucleus+Structures-definition/

Cell nucleus - WikipediaCell nucleus - Wikipedia

Structures. The nucleus is the largest organelle in animal cells.[5] In mammalian cells, the average diameter of the nucleus is ... Nuclei per cell. Most eukaryotic cell types usually have a single nucleus, but some have no nuclei, while others have several. ... In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-bound organelle ... Anucleated cells. Human red blood cells, like those of other mammals, lack nuclei. This occurs as a normal part of the cells ...
more infohttps://en.m.wikipedia.org/wiki/Cell_nuclei

CELL STRUCTURE & ORGANELLES (ORGANELLES IN EUKARYOTE (NUCLEUS…CELL STRUCTURE & ORGANELLES (ORGANELLES IN EUKARYOTE (NUCLEUS

... : CELL STRUCTURE & ORGANELLES ... eukaryotic cells engulfed and oxygen-using non photosynthetic prokaryotic cell. * eg. mitochondria (structure of mitochondria ... after nuclear division, vesicles move to region between daughter nuclei. * membranes fuse and become new cell surface membrane ... when cell wall is coated with glycocalyx - helps cell adhere to surfaces, protects it from attack by parasites ...
more infohttps://coggle.it/diagram/W5DTvWRd2xRiimEt/t/cell-structure-organelles

Nucleus - Cell Structure and Organelles - Biology - CollegeNucleus - Cell Structure and Organelles - Biology - College

Cell Structure and Organelles - Biology - College faster and easier with Picmonics unforgettable images and stories! Picmonic ...
more infohttps://www.picmonic.com/pathways/college/courses/standard/biology-3732/cell-structure-and-organelles-22756/nucleus_7296

Material Search ResultsMaterial Search Results

7.60 Cell Biology: Structure and... 7.60 Cell Biology: Structure and Functions of the Nucleus ... 7.60 Cell Biology: Structure and Functions of the Nucleus This course covers the fundamentals of nuclear cell biology as well ... 7.343 Neuron-glial Cell Interactions... 7.343 Neuron-glial Cell Interactions in Biology and Disease ... 7.343 Neuron-glial Cell Interactions in Biology and Disease The main goal of this seminar will be to study the nervous system ...
more infohttps://www.merlot.org/merlot/materials.htm?page=7&userId=34860&nosearchlanguage=&pageSize=

lifelife101 on Flipboardlifelife101 on Flipboard

Structure and Function of the Cell Nucleus. Telomere. For the use of "telomere" in insect morphology, see Telomere (insect ... Telomere Biology, Cell Therapies and Stem Cells , Academic researchers. Clinical implications of the use of stem cells with ... What is stem cell therapy. Maybe living in space reverses aging processes. Maybe living in space reverses aging processes,p, ... Stem Cells. Telomere Biology and Cancer - Prognostic Biomarker , Academic researchers. Around 6,500 publications in PubMed ...
more infohttps://flipboard.com/@lifelife101

The Nucleus - Definition, Structure, and FunctionThe Nucleus - Definition, Structure, and Function

The cell nucleus is the command center of our cells. It contains our chromosomes and genetic information needed for the ... Eukaryotic Cell Structures The cell nucleus is only one type of cell organelle. The following cell structures can also be found ... The Cell Nucleus You can think of the cell nucleus as a kind of command center containing all the chromosomal and genetic ... The cell nucleus​ is a membrane bound structure that contains the cells hereditary information and controls the cells growth ...
more infohttps://www.thoughtco.com/the-cell-nucleus-373362

7.60 Cell Biology: Structure and Functions of the Nucleus - MIT Textbooks7.60 Cell Biology: Structure and Functions of the Nucleus - MIT Textbooks

Structure and Functions of the Nucleus at MIT Textbooks. Eukaryotic genome structure, function, and expression, processing of ... RNA, and regulation of the cell cycle. Emphasis on the techniques and logic used... ... Buy and sell both new and used textbooks for 7.60 Cell Biology: ... 7.60 Cell Biology: Structure and Functions of the Nucleus. ... Structure and Functions of the Nucleus On The Web. MIT Department of Biology: 7.60 Cell Biology: Structure and Functions of the ...
more infohttp://textbooksearch.mit.edu/class/7.60

Research | University of St AndrewsResearch | University of St Andrews

Structure and dynamics of the mammalian cell nucleus. :: Dr Judith Sleeman. Senior Lecturer in Cell and Developmental Biology ...
more infohttps://www.st-andrews.ac.uk/bsrc/research/index.php?group=bsrc_molmed

NAVER Academic | Chromatin Structure Exhibits Spatio-Temporal Heterogeneity within the Cell NucleusNAVER Academic | Chromatin Structure Exhibits Spatio-Temporal Heterogeneity within the Cell Nucleus

... the direct measurement of the fluidity of chromatin structure is carried out in single live cells using steady-state anisotropy ... With cell cycle, the distribution in compaction heterogeneity continually changes maximizing during M-G1 transition where it ... of spatio-temporal chromatin fluidity could have broader implications in understanding chromatin remodeling within living cells ... Adenosine Triphosphate, metabolism, Animals, Cell Cycle, physiology, Cell Death, Cell Nucleus, ultrastructure, Cells, Cultured ...
more infohttps://academic.naver.com/article.naver?doc_id=146517084

M The Nucleus M The Cytoskeleton M Cell Structure and Dynamics - PDFM The Nucleus M The Cytoskeleton M Cell Structure and Dynamics - PDF

Download "M110.726 The Nucleus M110.727 The Cytoskeleton M340.703 Cell Structure and Dynamics" ... PROGRAMME IN CELL AND MOLECULAR BIOLOGY 5 YEAR INTEGRATED M.Sc. PROGRAMME IN CELL AND MOLECULAR BIOLOGY Highlight of the ... principles and limitations of current methods for analyzing macromolecules M The Nucleus M The Cytoskeleton M Cell Structure ... Study Program Handbook Biochemistry and Cell Biology Study Program Handbook Biochemistry and Cell Biology Bachelor of Science ...
more infohttp://docplayer.net/14612209-M110-726-the-nucleus-m110-727-the-cytoskeleton-m340-703-cell-structure-and-dynamics.html

Cell nucleusCell nucleus

In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, kernel) is a membrane-enclosed organelle found in ... Structure. The nucleus is the largest cellular organelle in animals.[4] In mammalian cells, the average diameter typically ... Although most cells have a single nucleus, some cell types have no nucleus, and others have many nuclei. This can be a normal ... In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, kernel) is a membrane-enclosed organelle found in ...
more infohttps://www.bionity.com/en/encyclopedia/Cell_nucleus.html

Optimizing Live Cell Imaging with FRET Microscopy TechniqueOptimizing Live Cell Imaging with FRET Microscopy Technique

3D Structured Illumination Microscopy Provides New Insights into Cell Nucleus. Using Selective Plane Illumination Microscopy ... Cell Counting Without Slides to Reduce Waste and Cost. Daniel Schieffer. Until recently, cells were typically counted on a ... The nature of molecular interactions in living cells is a key topic of interest across many areas of biological research. ... Andor Technology Ltd.. (2019, January 07). Optimizing Live Cell Imaging with FRET Microscopy Technique. News-Medical. Retrieved ...
more infohttps://www.news-medical.net/whitepaper/20150413/Optimizing-Live-Cell-Imaging-with-FRET-Microscopy-Technique.aspx

How is the structure around a given atom related to | bartlebyHow is the structure around a given atom related to | bartleby

Unlike eukaryotic cells, prokaryotic cells ______. a. have no nucleus b. have RNA but not DNA c. have no riboso.... Biology: ... How the structure around a given atom is related to repulsion between valence electron pairs on the atom is to be stated. ... The structure around a given atom in some of the molecules such as ammonia is related to repulsion between valence electron ... How is the structure around a given atom related to repulsion between valence electron pairs on the atom? ...
more infohttps://www.bartleby.com/solution-answer/chapter-12-problem-75qap-introductory-chemistry-a-foundation-9th-edition/9781337399425/how-is-the-structure-around-a-given-atom-related-to-repulsion-between-valence-electron-pairs-on-the/355a67c3-252d-11e9-8385-02ee952b546e

Cell nucleus - wikidocCell nucleus - wikidoc

Structure. The nucleus is the largest cellular organelle in animals.[4] In mammalian cells, the average diameter typically ... Although most cells have a single nucleus, some cell types have no nucleus, and others have many nuclei. This can be a normal ... In cell biology, the nucleus (pl. nuclei; from Latin [nucleus] error: {{lang}}: text has italic markup (help) or [nuculeus] ... Cell nucleus simple:Cell nucleus sk:Bunkové jadro sl:Celično jedro sr:Једро sh:Jezgra (stanica) fi:Tuma sv:Cellkärna th:นิวเคลี ...
more infohttps://www.wikidoc.org/index.php/Cell_nucleus

Replication timing - WikipediaReplication timing - Wikipedia

Replication timing and chromosome structure[edit]. Figure 5. Nucleus of a female amniotic fluid cell. Top: Both X-chromosome ... In eukaryotic cells (cells that package their DNA within a nucleus), chromosomes consist of very long linear double-stranded ... It was also noticed by Mary Lyon [9] that the inactive X took on a condensed structure in the nucleus called the Barr body [10] ... all of the DNA in a cell is duplicated in order to provide one copy to each of the daughter cells after the next cell division ...
more infohttps://en.wikipedia.org/wiki/Replication_timing

Plant Nuclei Can Contain Extensive Grooves and Invaginations | Plant CellPlant Nuclei Can Contain Extensive Grooves and Invaginations | Plant Cell

We have furthermore observed similar structures in the nuclei of suspension-cultured tobacco cells. These structures, similar ... these structures in tobacco NT1 and onion epidermal cells and observed similar structures in the epidermal nuclei of cells in ... 1998a). The nucleus of HeLa cell contains tubular structures for Ca2+ signalling. Biochem. Biophys. Res. Commun. 247, 88-93. ... 1993). Basket-shaped structures formed by F-actin in the nuclei of elongating cells of Nicotiana tabacum. Can. J. Bot. 71, 725- ...
more infohttp://www.plantcell.org/content/12/12/2425

ExploreLearning Gizmos: Math & Science Simulations Powering Inquiry and UnderstandingExploreLearning Gizmos: Math & Science Simulations Powering Inquiry and Understanding

S7L2.b: Relate cell structures (cell membrane, nucleus, cytoplasm, chloroplasts, mitochondria) to basic cell functions.. Cell ... Cell Structure. RNA and Protein Synthesis. S7L2.c: Explain that cells are organized into tissues, tissues into organs, organs ... S7L2: Students will describe the structure and function of cells, tissues, organs, and organ systems.. ... S7L2.d: Explain that tissues, organs, and organ systems serve the needs cells have for oxygen, food, and waste removal.. ...
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Lecture number 1. Cell theory. The central dogma of molecular biology. The structure of the cell nucleusLecture number 1. Cell theory. The central dogma of molecular biology. The structure of the cell nucleus

The role of the nucleus in the cell viability. Cell Cycle ,/p, ... The role of proteins in living cells. Genes. The principle of ... p, The structure of the plant and the living cell. Structural and functional education cells. ... Lecture number 1. Cell theory. The central dogma of molecular biology. The structure of the cell nucleus. 2nd lecture from ... Feedback about lecture Lecture number 1. Cell theory. The central dogma of molecular biology. The structure of the cell nucleus ...
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  • The goal of this course is to teach both the fundamentals of nuclear cell biology as well as the methodological and experimental approaches upon which they are based. (mit.edu)
  • Lectures and class discussions will cover the background and fundamental findings in a particular area of nuclear cell biology. (mit.edu)
  • This course covers the fundamentals of nuclear cell biology as well as the methodological and experimental approaches upon which they are based. (mit.edu)
  • The techniques and logic used to address important problems in nuclear cell biology is emphasized. (mit.edu)
  • Lectures cover broad topic areas in nuclear cell biology and class discussions focus on representative papers recently published in the field. (mit.edu)
  • The findings by Audrey Wang and Colin Stewart of A*STAR's Institute of Medical Biology and Irina Solovei, Boris Joffe and Heinrich Leonhardt of the Ludwig Maximillian University in Munich, Germany, were recently published in the prestigious journal Cell. (technologynetworks.com)
  • Lectures on broad topic areas in nuclear cell biology and discussions on representative recent papers. (mit.edu)
  • You can find more information at the MIT Department of Biology: 7.60 Cell Biology: Structure and Functions of the Nucleus site or on the 7.60 Stellar site. (mit.edu)
  • I have been assigned the cell wall, and cell membrane for a biology project. (brainmass.com)
  • 3) reproduce knowledge on the role of cell biology in understanding and developing drugs and drug efficacy. (rug.nl)
  • Our research group in the Department of Cell Biology at Yale University School of Medicine is developing new fluorescence microscopy techniques with spatial and/or temporal resolutions exceeding far beyond current technology and also applying them to a diverse set of biological questions. (yale.edu)
  • We tried very hard to examine the effect of methylene blue on all known progeria symptoms within the cell," said Kan Cao, senior author on the study and an associate professor of cell biology and molecular genetics at UMD. (prweb.com)
  • We have repeated these experiments many times and have not seen a single one fail," said Zheng-Mei Xiong, lead author on the study and a postdoctoral associate in the UMD Department of Cell Biology and Molecular Genetics. (prweb.com)
  • The overall information processes of the cell are given in the Central Dogma of Molecular Biology: DNA makes RNA makes Protein. (smore.com)
  • The substantial increase in nuclear surface area resulting from these grooves and invaginations, their apparent preference for association with nucleoli, and the presence in them of actin bundles that support vesicle motility suggest that the structures might function both in mRNA export from the nucleus and in protein import from the cytoplasm to the nucleus. (plantcell.org)
  • To understand mechanisms that initiate reproduction, we isolated a mutation in Arabidopsis , f644 , that allows for replication of the central cell and subsequent endosperm development without fertilization. (pnas.org)
  • M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place. (uniprot.org)
  • Both viruses infect T lymphocytes, monocytes and macrophages, and their replication cycle in infected cells is analogous. (mdpi.com)
  • Due to marked similarity in genomic organization, virus structure, virus replication and disease pathogenesis of FIV and HIV, infection of cats with FIV is a useful tool to study and develop novel drugs and vaccines for HIV. (mdpi.com)
  • The viral replication strategy is highly similar to that of HIV, and is initiated by interaction of the viral Env glycoprotein with CD134, a molecule up-regulated on activated CD4 + T cells [ 5 ]. (mdpi.com)
  • Others (granule, Golgi and unipolar brush cell) are currently under study but their basic function may be generally understood by analogy to their counterparts in the cerebellar cortex and ELL. (frontiersin.org)
  • The non-auditory domain receives mossy fiber input to granule cells, and is modified by Golgi and unipolar brush cells. (frontiersin.org)
  • Like plants, fungi cells are surrounded by cell walls, but the cell walls do not have chloroplasts, which are the units in which photosynthesis happens, because fungi do not make food from the sun. (reference.com)
  • The EMCCD cameras developed by Andor Technology provide a reliable tool for FRET imaging, whether used as an EMCCD + iQ imaging software solution or as a main component in Andor's Revolution confocal live cell imaging system. (news-medical.net)
  • For hundreds of years before this discovery, scientists were puzzled by why heterochromatin clustered at the edge of the nucleus and how it was relevant to normal cell function. (technologynetworks.com)
  • The function of the nucleus remained unclear. (wikipedia.org)
  • Nuclear transport is of paramount importance to cell function, as movement through the pores is required for both gene expression and chromosomal maintenance. (bionity.com)
  • Nuclear transport is crucial to cell function, as movement through the pores is required for both gene expression and chromosomal maintenance. (wikidoc.org)
  • Nuclear grooves and invaginations substantially increase the surface area of the nucleus and have been suggested to function in signaling from the cytoplasm to the nucleus (Lui et al. (plantcell.org)
  • Students will describe the structure and function of cells, tissues, organs, and organ systems. (explorelearning.com)
  • structure and function of carbohydrate processing enzymes. (st-andrews.ac.uk)
  • The function of some of these interneurons (tuberculoventral or vertical cell, and the cartwheel cell) have been established through a combination of in vivo and in vitro studies over many years. (frontiersin.org)
  • The final number of nuclei at each region was determined by minimizing an objective function that iterated all of the possible k -values. (spiedigitallibrary.org)
  • This allows material (in particular calcium ions) to pass through, affecting the function of the cell. (wired.com)
  • Crotalus durissus terrificus venom and its components can affect a variety of cell types, including macrophages (9), neutrophils (34), mast cells (8), platelets (7) and cells in culture (14), as well as the function of organs such as the heart (19) and the kidney (22). (scielo.br)
  • Most RNAs function in an information carrying and/or processing mode in the cell. (smore.com)
  • But the structure of each leaf cells varies with its function in the leaf. (ehow.co.uk)
  • Explain that cells are organized into tissues, tissues into organs, organs into systems, and systems into organisms. (explorelearning.com)
  • Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms. (uniprot.org)
  • The body's immune system is a network of cells and tissues responsible for clearing the body of invading organisms, like bacteria, viruses, and fungi. (encyclopedia.com)
  • One of the clues to the complex causes of ageing could be found in the malfunctioning of tiny organisms within the cells of our bodies. (ncl.ac.uk)
  • These clusters resisted mechanical disruption and showed evidence of cell-cell signalling via gap junctions. (nih.gov)
  • Agata Smogorzewska, head of the Laboratory of Genome Maintenance, wants to understand how cells repair interstrand cross-links, a particular type of DNA damage in which the two strands of the double helix that normally twine about each other become physically linked. (medicalnewstoday.com)
  • Explain that tissues, organs, and organ systems serve the needs cells have for oxygen, food, and waste removal. (explorelearning.com)
  • General aspects of methods for studying cells and tissues. (unimi.it)
  • the organisation of cells in tissues. (unimi.it)
  • Cells and chemicals of the immune system damage the tissues of the body. (encyclopedia.com)
  • Administration of the treatment consists of daily doses over duration of 2 days or more, ensuring the test chemical reaches the target tissue which can be the liver, the kidney or other tissues if justified.Tissues of interest are dissected and single cells/nuclei suspensions are prepared and embedded in agarose on slides. (oecd.org)
  • ribonucleic acid, a nucleic acid present in all living cells. (smore.com)
  • Fungi are structured in filaments called hyphae, which are made up strings of cells and separated from one another by septa or crosswalls. (reference.com)
  • Although the majority of fungi are made up of hyphae filaments forming a mycelium structure, coenocytic hyphae are net separated by walls. (reference.com)
  • These channels, referred to as tunneling nanotubes (TNT), were shown to actively traffic cytosolic content from cell to cell within the interior of their filaments . (plos.org)
  • In addition, when H2A.Z was studied in human and yeast cells, it was used to promote RNA polymerase II recruitment. (wikipedia.org)
  • Using a morphological operation and thresholding technique on the hematoxylin channel image, candidate target nuclei and background regions were detected, which were then used as markers for a marker-controlled watershed transform segmentation algorithm. (spiedigitallibrary.org)
  • Hematoxylin stains the nuclei in a dark blue color while eosin stains cytoplasm as pink, 5 which enables morphological feature analysis related to cell nuclei. (spiedigitallibrary.org)
  • By comparing AFM images with corresponding light microscopy images of the same area, the progressive formation of cavities due to cell necrosis was identified as a typical morphological marker for a computer-assisted analysis. (hindawi.com)
  • Visualizing 3D structure and dynamics at the molecular scale is a current and critical need in biomedical research. (yale.edu)
  • For example Insulin exerts its effects on the cell by binding onto a special receptor (see Membrane Dynamics ). (wikibooks.org)
  • Interestingly, we found a higher amount of NF-IL6-CD68-positive cells in the posterior pituitary of old rats compared to the young counterparts. (nih.gov)
  • What Important Structures Are Found Inside the Nucleus? (reference.com)
  • But the most significant is a paper which found that it was possible to incapacitate cells for a prolonged period \- 'our study provides experimental evidence that even a single 60-ns pulse at 12 kV/cm can cause a profound and long-lasting (minutes) reduction of the cell membrane resistance (Rm), accompanied by the loss of the membrane potential. (wired.com)
  • We found that Meis1 is expressed in GC lineage cells and astrocytes in the cerebellum during development. (jneurosci.org)
  • His lab found further evidence for this idea in 2005 when they showed that paraspeckles - each nucleus has about 10 to 30 of these scattered around - fell apart when cells were treated with an enzyme that destroys RNA. (scienceblog.com)
  • 5. Aberrant cell cycle and cell death were found to have common features in embryonic development and tumours. (lza.lv)
  • psychexam1 - Psychology Exam 1 Nucleus biological control. (coursehero.com)
  • The nature of molecular interactions in living cells is a key topic of interest across many areas of biological research. (news-medical.net)
  • For the physical and computer scientist, this text provides an introduction to the basic biological principles governing a cell. (springer.com)
  • The Center's mission is to 'to increase scientific knowledge and understanding of how electromagnetic fields and ionized gases interact with biological cells. (wired.com)
  • Viewing of living cells in culture and of fixed and stained cells by light microscopy. (unimi.it)
  • This results in structures resembling comets which by using suitable fluorescent stain, can be observed by fluorescent microscopy. (oecd.org)
  • Small clusters of dye-retaining material could be seen in the nucleus (arrows), which upon further examination () appeared to be clusters of cells. (nih.gov)
  • Unlabeled arrows indicate nuclei derived from the unfertilized central cell. (pnas.org)
  • D and F ) Seeds with wild-type phenotype from f644 heterozygous silique in B . ( E and G ) Seeds with mutant phenotype from f644 heterozygous silique in B . Arrows in Inset point to nuclei. (pnas.org)