Cell Nucleus Shape: The quality of surface form or outline of the CELL NUCLEUS.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Stem Cell Research: Experimentation on STEM CELLS and on the use of stem cells.Viscosity: The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Nuclear Lamina: A lattice of fibrils which covers the entire inner surface of the nuclear envelope and interlinks nuclear pores (NUCLEAR PORE).Lamins: Nuclear matrix proteins that are structural components of the NUCLEAR LAMINA. They are found in most multicellular organisms.Manufactured Materials: Substances and materials manufactured for use in various technologies and industries and for domestic use.Nuclear Envelope: The membrane system of the CELL NUCLEUS that surrounds the nucleoplasm. It consists of two concentric membranes separated by the perinuclear space. The structures of the envelope where it opens to the cytoplasm are called the nuclear pores (NUCLEAR PORE).Image Cytometry: A technique encompassing morphometry, densitometry, neural networks, and expert systems that has numerous clinical and research applications and is particularly useful in anatomic pathology for the study of malignant lesions. The most common current application of image cytometry is for DNA analysis, followed by quantitation of immunohistochemical staining.Single-Cell Analysis: Assaying the products of or monitoring various biochemical processes and reactions in an individual cell.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Imaging, Three-Dimensional: The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.High-Throughput Screening Assays: Rapid methods of measuring the effects of an agent in a biological or chemical assay. The assay usually involves some form of automation or a way to conduct multiple assays at the same time using sample arrays.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Form Perception: The sensory discrimination of a pattern shape or outline.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Angiolymphoid Hyperplasia with Eosinophilia: Solitary or multiple benign cutaneous nodules comprised of immature and mature vascular structures intermingled with endothelial cells and a varied infiltrate of eosinophils, histiocytes, lymphocytes, and mast cells.Tripterygium: A plant genus of the family CELASTRACEAE that is a source of triterpenoids and diterpene epoxides such as triptolide.Progeria: An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.Aneugens: Agents which affect CELL DIVISION and the MITOTIC SPINDLE APPARATUS resulting in the loss or gain of whole CHROMOSOMES, thereby inducing an ANEUPLOIDY.Polysaccharide-Lyases: A group of carbon-oxygen lyases. These enzymes catalyze the breakage of a carbon-oxygen bond in polysaccharides leading to an unsaturated product and the elimination of an alcohol. EC 4.2.2.Lymphoma, Primary Effusion: A rare neoplasm of large B-cells usually presenting as serious effusions without detectable tumor masses. The most common sites of involvement are the pleural, pericardial, and peritoneal cavities. It is associated with HUMAN HERPESVIRUS 8, most often occurring in the setting of immunodeficiency.Pectobacterium chrysanthemi: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that causes vascular wilts on a wide range of plant species. It was formerly named Erwinia chrysanthemi.Bibliography as Topic: Discussion of lists of works, documents or other publications, usually with some relationship between them, e.g., by a given author, on a given subject, or published in a given place, and differing from a catalog in that its contents are restricted to holdings of a single collection, library, or group of libraries. (from The ALA Glossary of Library and Information Science, 1983)Bibliography of Medicine: A list of works, documents, and other publications on medical subjects and topics of interest to the field of medicine.Herpesvirus 8, Human: A species in the genus RHADINOVIRUS, subfamily GAMMAHERPESVIRINAE, isolated from patients with AIDS-related and "classical" Kaposi sarcoma.Earth Sciences: Fields of science encompassing studies and research from the disciplines of PHYSICS; CHEMISTRY; BIOLOGICAL SCIENCES; and MATHEMATICS; that are related to the planet EARTH. Subfields include atmospheric chemistry; CLIMATOLOGY; ENVIRONMENTAL SCIENCES; GEOGRAPHY; GEOLOGY; geophysics; METEOROLOGY; OCEANOGRAPHY; PALEONTOLOGY; mineralogy; and seismology.Science: The study of natural phenomena by observation, measurement, and experimentation.Physics: The study of those aspects of energy and matter in terms of elementary principles and laws. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Lamin Type A: A subclass of developmentally regulated lamins having a neutral isoelectric point. They are found to disassociate from nuclear membranes during mitosis.Organelle Shape: The quality of surface form or outline of ORGANELLES.Newspapers: Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)BooksCatalogs, LibraryMultiple Organ Failure: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.Catalogs as Topic: Ordered compilations of item descriptions and sufficient information to afford access to them.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Mass Media: Instruments or technological means of communication that reach large numbers of people with a common message: press, radio, television, etc.Cell Shape: The quality of surface form or outline of CELLS.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Academies and Institutes: Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.LondonNational Human Genome Research Institute (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research into the mapping of the human genome and other organism genomes. The National Center for Human Genome Research was established in 1989 and re-named the National Human Genome Research Institute in 1997.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Cerebrum: Derived from TELENCEPHALON, cerebrum is composed of a right and a left hemisphere. Each contains an outer cerebral cortex and a subcortical basal ganglia. The cerebrum includes all parts within the skull except the MEDULLA OBLONGATA, the PONS, and the CEREBELLUM. Cerebral functions include sensorimotor, emotional, and intellectual activities.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Central Nervous System: The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)Histology: The study of the structure of various TISSUES of organisms on a microscopic level.Receptors, N-Acetylglucosamine: Cell surface receptors that bind to ACETYLGLUCOSAMINE.

Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence. (1/80)

Lipodystrophic syndromes associated with mutations in LMNA, encoding A-type lamins, and with HIV antiretroviral treatments share several clinical characteristics. Nuclear alterations and prelamin A accumulation have been reported in fibroblasts from patients with LMNA mutations and adipocytes exposed to protease inhibitors (PI). As genetically altered lamin A maturation also results in premature ageing syndromes with lipodystrophy, we studied prelamin A expression and senescence markers in cultured human fibroblasts bearing six different LMNA mutations or treated with PIs. As compared to control cells, fibroblasts with LMNA mutations or treated with PIs had nuclear shape abnormalities and reduced proliferative activity that worsened with increasing cellular passages. They exhibited prelamin A accumulation, increased oxidative stress, decreased expression of mitochondrial respiratory chain proteins and premature cellular senescence. Inhibition of prelamin A farnesylation prevented cellular senescence and oxidative stress. Adipose tissue samples from patients with LMNA mutations or treated with PIs also showed retention of prelamin A, overexpression of the cell cycle checkpoint inhibitor p16 and altered mitochondrial markers. Thus, both LMNA mutations and PI treatment result in accumulation of farnesylated prelamin A and oxidative stress that trigger premature cellular senescence. These alterations could participate in the pathophysiology of lipodystrophic syndromes and lead to premature ageing complications.  (+info)

CD200 and its receptor, CD200R, modulate bone mass via the differentiation of osteoclasts. (2/80)

Fusion of macrophages is an essential step in the differentiation of osteoclasts, which play a central role in the development and remodeling of bone. Osteoclasts are important mediators of bone loss, which leads, for example, to osteoporosis. Macrophage fusion receptor/signal regulatory protein alpha (MFR/SIRPalpha) and its ligand CD47, which are members of the Ig superfamily (IgSF), have been implicated in the fusion of macrophages. We show that CD200, which is not expressed in cells that belong to the myeloid lineage, is strongly expressed in macrophages at the onset of fusion. By contrast, the CD200 receptor (CD200R), which, like CD200, belongs to the IgSF, is expressed only in cells that belong to the myeloid lineage, including osteoclasts, and in CD4+ T cells. Osteoclasts from CD200-/- mice differentiated at a reduced rate. Activation of the NF-kappaB and MAP kinase signaling pathways downstream of RANK, a receptor that plays a central role in the differentiation of osteoclasts, was depressed in these cells. A soluble recombinant protein that included the extracellular domain of CD200 rescued the fusion of CD200-/- macrophages and their activation downstream of RANK. Conversely, addition of a soluble recombinant protein that included the extracellular domain of CD200R or short-hairpin RNA-mediated silencing of the expression of CD200R prevented fusion. Thus CD200 engagement of the CD200R at the initiation of macrophage fusion regulated further differentiation to osteoclasts. Consistent with in vitro observations, CD200-/- mice contained fewer osteoclasts and accumulated more bone than CD200+/+ mice. The CD200-CD200R axis is therefore a putative regulator of bone mass, via the formation of osteoclasts.  (+info)

Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment. (3/80)

BACKGROUND: Previously, 50% of patients with breast ductal carcinoma in situ (DCIS) had more than one nuclear grade, and neither worst nor predominant nuclear grade was significantly associated with development of invasive carcinoma. Here, we used image analysis in addition to histologic evaluation to determine if quantification of nuclear features could provide additional prognostic information and hence impact prognostic assessments. METHODS: Nuclear image features were extracted from about 200 nuclei of each of 80 patients with DCIS who underwent lumpectomy alone, and received no adjuvant systemic therapy. Nuclear images were obtained from 20 representative nuclei per duct, from each of a group of 5 ducts, in two separate fields, for 10 ducts. Reproducibility of image analysis features was determined, as was the ability of features to discriminate between nuclear grades. Patient information was available about clinical factors (age and method of DCIS detection), pathologic factors (DCIS size, nuclear grade, margin size, and amount of parenchymal involvement), and 39 image features (morphology, densitometry, and texture). The prognostic effects of these factors and features on the development of invasive breast cancer were examined with Cox step-wise multivariate regression. RESULTS: Duplicate measurements were similar for 89.7% to 97.4% of assessed image features. For the pooled assessment with approximately 200 nuclei per patient, a discriminant function with one densitometric and two texture features was significantly (p < 0.001) associated with nuclear grading, and provided 78.8% correct jackknifed classification of a patient's nuclear grade. In multivariate assessments, image analysis nuclear features had significant prognostic associations (p +info)

A novel function of plant histone H1: microtubule nucleation and continuous plus end association. (4/80)

In higher plant cells, various microtubular arrays can be seen despite of their lack of structurally defined microtubule-organizing centers (MTOCs) like centrosomes in animal cells. Little is known about the molecular properties of the microtubule-organizing centers in higher plant cells. The nuclear surface contains one of these microtubule-organizing centers and generates microtubules radially toward the cell periphery (radial microtubules). Previously, we reported that histone H1 possessed the microtubule-organizing activity, and it was suggested that histone H1 localized on the nuclear surfaces in Tobacco BY-2 cells (Nakayama, T., Ishii, T., Hotta, T., and Mizuno, K. J. Biol. Chem. (submitted)). Here we show that histone H1 forms ring-shaped complexes with tubulin, and these complexes nucleated and elongated the radial microtubules continuously (processively) associating with their proximal ends where the incorporation of tubulin occurred. Furthermore, the polarity of radial microtubules was determined to be proximal end plus. Immunofluorescence microscopy of the isolated nuclei revealed that histone H1 localized on the nuclear surfaces, distinct from that in the chromatin. These results indicate that radial microtubules are organized by a novel MTOC that is totally different from MTOCs previously found in either plant or animal cells.  (+info)

Automated learning of generative models for subcellular location: building blocks for systems biology. (5/80)

The goal of location proteomics is the systematic and comprehensive study of protein subcellular location. We have previously developed automated, quantitative methods to identify protein subcellular location families, but there have been no effective means of communicating their patterns to integrate them with other information for building cell models. We built generative models of subcellular location that are learned from a collection of images so that they not only represent the pattern, but also capture its variation from cell to cell. Our models contain three components: a nuclear model, a cell shape model and a protein-containing object model. We built models for six patterns that consist primarily of discrete structures. To validate the generated images, we showed that they are recognized with reasonable accuracy by a classifier trained on real images. We also showed that the model parameters themselves can be used as features to discriminate the classes. The models allow the synthesis of images with the expectation that they are drawn from the same underlying statistical distribution as the images used to train them. They can potentially be combined for many proteins to yield a high resolution location map in support of systems biology.  (+info)

The human granulocyte nucleus: Unusual nuclear envelope and heterochromatin composition. (6/80)

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Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin. (7/80)

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p300 (histone acetyltransferase) biomarker predicts prostate cancer biochemical recurrence and correlates with changes in epithelia nuclear size and shape. (8/80)

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Sigma-Aldrich offers abstracts and full-text articles by [Khatau, SB; Hale, CM; Stewart-Hutchinson, PJ; Patel, MS; Stewart, CL; Searson, PC; Hodzic et al.].
Early-stage estrogen receptor-positive (ER+) breast cancer (BCa) is the most common type of BCa in the United States. One critical question with these tumors is identifying which patients will receive added benefit from adjuvant chemotherapy. Nuclear pleomorphism (variance in nuclear shape and morphology) is an important constituent of breast grading schemes, and in ER+ cases, the grade is highly correlated with disease outcome. This study aimed to investigate whether quantitative computer-extracted image features of nuclear shape and orientation on digitized images of hematoxylin-stained and eosin-stained tissue of lymph node-negative (LN-), ER+ BCa could help stratify patients into discrete (,10 years short-term vs. ,10 years long-term survival) outcome groups independent of standard clinical and pathological parameters. We considered a tissue microarray (TMA) cohort of 276 ER+, LN- patients comprising 150 patients with long-term and 126 patients with short-term overall survival, wherein 177 ...
M. Yampolsky, C. Salafia, O. Shlakhter, D. Misra, D. Haas, B. Eucker, J. Thorp. Variable placental thickness affects placental functional efficiency independent of other placental shape abnormalities Journal of Developmental Origins of Health and Disease (2011) Volume 2, Issue 04, pp 205 - 211, Cambridge University Press ...
Many phenomena that basic research tries to explain would simply be unknown had they not been uncovered by the study of diseases". This statement from Vogel and Motulsky is also valid with respect to protein modifications in both "normal" and premature ageing, such as Hutchinson-Gilford Progeria. Most progeria patients carry a specific lamin A/C mutation, which results in truncated protein (progerin), lacking the site essential for cleaving a farnesyl group. Incompletely modified lamins accumulate at the nuclear membrane. The same lamin modifications are also found in cells of normally aged humans. Further, lamins are non-enzymatically modified by MGO, a precursor in the formation of AGEs. These lamin modifications increase with age and might cause vascular dysfunction and atherosclerosis. Amongst others, lamins bind to the lamin B receptor (LBR). LBR has sterol reductase activity and modifies chromatin. We previously showed that LBR-deficiency results in hyposegmented neutrophil nuclei, altered ...
Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells ...
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The objective of this study was to evaluate synchronous and asynchronous pronucleus (PN) formation and the related patterns of juxtapositional nucleolus (n) formation in immature (prophase I [PI] and...
Description: Glyphosate based herbicides are among the most widely used herbicides in the world. The purpose of this study was to determine developmental toxicity of glyphosate, the active ingredient in the common herbicide Roundup, on developing chicken embryos. Few studies have examined toxic effects of glyphosate alone versus the full compound formulations of Roundup, which include adjuvants and surfactants. Adjutants and surfactants are added to aid in solubility and absorption of glyphosate. In this study chicken embryos were exposed at the air cell on embryonic day 6 to 19.8 or 9.9 mg / Kg egg mass of glyphosate in Roundup or glyphosate only. Chickens treated with 19.8 and 9.9 mg / Kg glyphosate in Roundup showed significant reduction in survivability compared to glyphosate alone treatments and controls. On embryonic day 18, embryos were sacrificed for evaluation of developmental toxicity using wet embryo mass, dry embryo mass, and yolk mass as indicators. Morphology measurements were ...
Rac2D57N is the only mutation in any Rho GTPase identified in a human syndrome (Ambruso et al., 2000). The patient harboring the Rac2D57N mutation had severe neutrophil dysfunction characterized by impaired responsiveness to Gram-negative bacteria. Rac2 expression in different hematopoietic cell lineages indicates the potential for defects induced by Rac2D57N in multiple cell types. Using quantitative RT-PCR, we showed that Rac2 is expressed at levels similar to Rac1 in the primary murine macrophage prompting the examination of the effect of Rac2D57N expression in the macrophage. Our studies, for the first time, clearly demonstrate two inhibitory functions of Rac2D57N that effect remodeling of the actin cytoskeleton and MAPK signal transduction. Thus, Rac2D57N functions as a dominant inhibitory mutant.. Rac2D57N has dramatic effects on the macrophage actin cytoskeleton. Rac2D57N was found in the cell cytoplasm and periphery, and colocalized with large, perinuclear actin aggregates. Rac2D57N ...
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Quantify the intensity and amount of staining in cell nuclei, while including only cells of interest based on nuclear morphology and size.
The aging process can be accelerated by numerous cellular and molecular variables. Progeroid syndromes are one such example. The phenotypes of Hutchinson-Gilford Progeria Syndrome (HGPS) and Restrictive Dermopathy (RD) are both caused by an irregular pathway of the processing of prelamin A to mature lamin A, an integral component of the nuclear lamina. In wild-type cells, prelamin A undergoes farnesylation followed by cleavage that is carried out by the enzyme Zmpste24. A 50 amino acid deletion in the LMNA gene found in HGPS patients eliminates the cleavage site in prelamin A, causing an accumulation of farnesylated prelamin A. The buildup of this protein, known as progerin/LA∆50, occurs at the nuclear rim. In RD, nonfarnesylated and farnesylated prelamin A build up due to a deficiency in the Zmpste24 cleaving enzyme. In both syndromes, however, the accumulation of the different forms of prelamin A causes nuclear shape abnormalities and leads to phenotypes resembling premature aging. Currently, there
The structure of the doubly-odd180 Re nucleus has been studied by means of in-beam gamma-ray spectroscopy at the Australian National University. Excited states in 180 Re have been populated using the fusion-evaporation reaction 174Yb(11B,5n) at a bombarding energy of 71 MeV. Gamma-rays have been observed by using the CAESAR detector array which consists of six Hyper-Pure Germanium (HPGe) detector and two Low Energy Photon Spectrometers (LEPS). The level scheme of 180 Re was established from the analysis of gamma-gamma coincidence relations, Directional Correlations of gamma-rays from Oriented states (DCO), electron conversion measurements and gamma-ray intensity balances. Energy levels of intrinsic states have been compared with calculations based on the Blocked BCS (BBCS) theory as well as Potential Energy Surface (PES) calculations which were also used to determine the nuclear shape. Previously identified bands have been observed in this work. Their band-head spins, however, have been ...
... , causes. Progeria disease is a genetic disorder characterized by rapid aging in children
Ramdas NM, Shivashankar GV. 2015. Cytoskeletal control of nuclear morphology and chromatin organization.. J Mol Biol. 427(3):695-706. ...
Dr. Robert J Asp, DDS, rated 3/5 by patients. 2 reviews, Phone number & practice locations, General Practitioner in Hilbert, WI.
Latest information about hyperkeratosis parakeratosis Find article, review, images and graphics related with hyperkeratosis parakeratosis here.
North Carolina State University Oxygen-16, one of the key elements of life on earth, is produced by a series of reactions inside of red giant stars. Now a team of physicists, including one from North Carolina State University, has revealed how the elements nuclear shape changes depending on its state, even though other attributes such as spin and parity dont appear to differ. Their findings may shed light on how oxygen is produced.. Carbon and oxygen are formed when helium burns inside of red giant stars. Carbon-12 forms when three helium-4 nuclei combine in a very specific way (called the triple alpha process), and oxygen-16 is the combination of a carbon-12 and another helium-4 nucleus.. Although physicists knew what oxygen-16 was made of, they were still puzzled by the fact that both the ground and first excited states of the element had zero spin and positive parity. A similar situation occurs in carbon-12 with the ground state and second zero-spin state known as the Hoyle state. At room ...
As cells mature, from the most immature or blast cell to the final mature stage, they undergo numerous biochemical, structural and metabolic changes. The cytologic features of cells, as observed on Wrights stained peripheral blood and bone marrow smears, reflect such biochemical and structural developments. The general features of cell differentiation are common to most blood cells. Immature cells have delicate, fine nuclear chromatin which gradually becomes coarsely clumped or condensed. The size of the nucleus decreases; nucleoli are reduced in number or lost completely as in red cells. The nuclear shape which is initially round or oval may become uniquely confirgured as in myeloid cells. Mitotic competence is lost as cells differentiate.. ...
Note: * indicates the first author conducted the study while working as a graduate student or postdoctoral student in my lab.. *Dean, D., Orr, J.M, Bernard, J., Gupta, T., Pelletier-Baldelli, A., Carol, E., Mittal, V.A. (in press) Hippocampal shape abnormalities predict symptom progression and impaired tolerance to stress in youth at ultrahigh risk for psychosis, Schizophrenia Bulletin. Mittal, VA, Gupta, T., Keane, B., Silverstein, S., (in press) Visual context processing dysfunctions in youth at high-risk for psychosis: Resistance to the Ebbinghaus illusion and its symptom and social and role functioning correlates. Journal of Abnormal Psychology. *Earls, H., Curran, T., Mittal, V.A. (in press). Social deficits in early perceptual stages in schizophrenia: A systematic review of the P100 during face processing. Schizophrenia Bulletin. *Bernard, J., Millman, Z., Mittal, V.A. (in press) Metaphoric and beat gestures are differentially associated with cortical and regional cerebellar volumes. Human ...
My laboratory would like to further examine the causative relationship between progerin production and the aging process, to study the regulation of progerin production in normal cells, and to determine the contribution of progerin in normal human aging. ...
College Park, MD (PRWEB) December 10, 2015 -- Progeria is a rare genetic disease that mimics the normal aging process at an accelerated rate. Symptoms
Aging affects all people and is a complex process involving both genetic and environmental factors in a way that is not yet completely understood. Studies of premature aging syndromes might be helpful to acquire further clues to understand the molecular mechanisms explaining how aging occurs. Hutchinson-Gilford progeria syndrome (HGPS or progeria) is a genetic disease causing segmental premature aging in children, with an approximated incidence of 1 in 20 million individuals. Children affected by progeria appear normal at birth, but they begin developing symptoms of disease within the first years of life. Symptoms of HGPS include severe growth retardation, scleroderma-like skin changes, bone and tooth abnormalities, and loss of hair and body fat. The children with progeria die prematurely at a median age of 14.6 years, due to complications from cardiovascular disease and atherosclerosis ...
Hutchinson-Gilford Progeria Syndrome is a very rare genetic condition, causing greatly accelerated ageing. There is a genetic test, but, as of May 2013, no cure.
the Hutchinson-Gilford progeria syndrome is a rare genetic condition that affects an estimated 1 in 8 million children. It is characterized by excessive
Parakeratosis is a mode of keratinization characterized by the retention of nuclei in the stratum corneum. In mucous membranes, parakeratosis is normal. In the skin, this process leads to the abnormal replacement of annular squames with nucleated cells. Parakeratosis is associated with the thinning or loss of the granular layer and is usually seen in diseases of increased cell turnover, whether inflammatory or neoplastic. Parakeratosis is seen in the plaques of psoriasis and in dandruff. Granular parakeratosis (originally termed axillary granular parakeratosis) is an idiopathic, benign, nondisabling cutaneous disease that manifests with intertriginous erythematous, brown or red, scaly or keratotic papules and plaques. It presents in all age groups and has no established clinical associations. Skin lesion Skin disease List of skin diseases Kumar, Vinay; Fausto, Nelson; Abbas, Abul (2010) Robbins & Cotran Pathologic Basis of Disease (8th ed.). Saunders. Page 1170. ISBN 978-1-4160-3121-5. ...
During interphase in all eukaryotic cells the double lipid bilayer of the nuclear envelope (NE) physically separates the chromosomes, and chromosome-related processes, from the cytoplasm and increases in area by 59% (Lim et al., 2007) as the nuclear volume doubles in preparation for mitosis (reviewed by Hetzer et al., 2005; Lim et al., 2007; Winey et al., 1997). In the open mitosis of animal cells, NE breakdown allows the spindle microtubules that are nucleated by the cytoplasmic centrosomes to attach to and then separate the chromosomes. In the closed mitosis of yeast, the centrosome equivalents, called spindle pole bodies (SPBs), are embedded in the NE and nucleate the formation of an intranuclear spindle (Ding et al., 1997). As the spindle elongates in anaphase B, nuclear volume remains constant but division of the roughly spherical nucleus into two smaller spheres, which occurs in less than 5 minutes, requires a rapid increase of 26% in NE area (Lim et al., 2007).. The nucleus, often thought ...
Progeria ( /proʊˈdʒɪəriə/)[1], also called Hutchinson-Gilford progeria syndrome[2][3] and HGPS progeria syndrome[3] is a very rare genetic disorder. Children born with progeria show symptoms which are like aging.[4] This can include skin wrinkles and grey hair or baldness.[1] Progeria is one of several progeroid syndromes.[5] The word progeria comes from the Greek words "pro" (πρό), meaning "before" or "premature", and "gēras" (γῆρας), meaning "old age".[6] It is very rare, only 1 child in every 8 million live births.[7] People with progeria usually only live to their mid teens to early twenties.[8][9] It is a genetic condition that occurs as a new mutation. It is rarely inherited, as people with the condition do not usually live long enough to have children. Scientists are studying progeria because it might reveal clues about the normal process of aging.[10][11][12] Progeria was first described in 1886 by Jonathan Hutchinson.[13] It was also described independently in 1897 by ...
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare hereditary disease that affects the skin, musculoskeletal system, and vasculature. HGPS is characterized by signs of premature aging.
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare hereditary disease that affects the skin, musculoskeletal system, and vasculature. HGPS is characterized by signs of premature aging.
... - Establishing the detailed phenotype of Hutchinson-Gilford progeria syndrome is important because advances in understanding this syndrome may offer
El Centro Nacional de Biotecnología es un centro estratégico del Consejo Superior de Investigaciones Científicas con un objetivo mixto académico y de transferencia de tecnología en el área de la Biotecnología.
Hutchinson-Gilford progeria syndrome (HGPS) is caused by a point mutation in the LMNA gene that activates a cryptic donor splice site and yields a truncated form of prelamin A called progerin. Small amounts of progerin are also produced during normal aging. Studies with mouse models of HGPS have allowed the recent development of the first therapeutic approaches for this disease. However, none of these earlier works have addressed the aberrant and pathogenic LMNA splicing observed in HGPS patients because of the lack of an appropriate mouse model. Here, we report a genetically modified mouse strain that carries the HGPS mutation. These mice accumulate progerin, present histological and transcriptional alterations characteristic of progeroid models, and phenocopy the main clinical manifestations of human HGPS, including shortened life span and bone and cardiovascular aberrations. Using this animal model, we have developed an antisense morpholino-based therapy that prevents the pathogenic Lmna ...
A mutant protein responsible for Hutchinson-Gilford Progeria syndrome (HGPS) bars large proteins from entering the nucleus, according to a study in The Journal of Cell Biology.
Learn about the veterinary topic of Overview of Parakeratosis. Find specific details on this topic and related topics from the Merck Vet Manual.
Hyperkeratosis, focal parakeratosis, irregular acanthosis, exocytosis, spongiosis, extravasated erythrocytes and perivascular mononuclear cell infiltration in d
Scientists at the University of Cambridge have identified a key chemical that can repair the damage to cells which causes a rare but devastating disease involving accelerated ageing. As well as offering a promising new way of treating the condition, known as Hutchinson-Gilford Progeria Syndrome (HGPS), the discovery could help in the development of drugs against cancer and other genetic diseases and might also suggest ways to alleviate diseases that we associate with normal ageing.. ...
Scientists at the University of Cambridge have identified a key chemical that can repair the damage to cells which causes a rare but devastating disease involving accelerated ageing. As well as offering a promising new way of treating the condition, known as Hutchinson-Gilford Progeria Syndrome (HGPS), the discovery could help in the development of drugs against cancer and other genetic diseases and might also suggest ways to alleviate diseases that we associate with normal ageing.. ...
Studies of chromosome and genome biology often focus on condensed chromatin in the form of chromosomes and neglect the non-dividing cells. Even when interphase nuclei are considered, they are often...
My laboratory would like to further examine the causative relationship between progerin production and the aging process, to study the regulation of progerin production in normal cells, and to determine the contribution of progerin in normal human aging. ...
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Scientists have discovered a drug they believe can reverse the effects of premature aging and could extend human life by over a decade. Rapamycin was created from a chemical found in the soil on Easter Island, which is one of the most remote places on Earth and 2,000 miles off the coast of Chile. The drug, which has been nicknamed the "forever young" drug, was used in experiments on children suffering from Hutchinson-Gilford Progeria Syndrome (HGPS). HGPS is a rare condition in which aging is hyper-accelerate and sufferers die of "old age" at around 12 years. HGPS causes a protein called progerin to build up in every cell of the body, causing them to age prematurely. Rapamycin cleaned the cells of progerin, which swept away the defects and left healthy cells. Researchers are expected to start looking at whether the drug could be used more widely, after similarities between HGPS and the normal aging process were uncovered. The drug is already used to suppress the immune system in organ ...
Progeria is a rare genetic condition characterized by an appearance of accelerated aging in children. Its name is derived from the Greek and means prematurely old. The classic type is the Hutchinson-Gilford Progeria Syndrome which was first described in England in 1886 by Dr. Jonathan Hutchinson and again in 1886 and 1904 by Dr. Hastings Gilford.
Looking for online definition of progeria in the Medical Dictionary? progeria explanation free. What is progeria? Meaning of progeria medical term. What does progeria mean?
Gruber, J.; Lampe, T.; Osborn, M.; Weber, K.: RNAi of FACE1 protease results in growth inhibition of human cells expressing lamin A: implications for Hutchinson-Gilford progeria syndrome. Journal of Cell Science 118, S. 689 - 696 (2005 ...
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Duke researchers have discovered a new way to model progeria syndrome-a rare genetic disease that accelerates aging in children-which could help pave the way for future treatments.
... is the progressive and extremely rare genetic disorder which causes a child to age rapidly, beginning in the first 2 years of life. This is the forum for discussing anything related to this health condition
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder wherein symptoms resembling aspects of aging are manifested at a very early age. It is a genetic condition that occurs due to a de novo mutation in the LMNA gene encoding for the nuclear structural protein lamin A. The lamin family of proteins are thought to be involved in nuclear stability, chromatin structure and gene expression and this leads to heavy effects on the regulation and functionality of the cell machinery. The functional role of the large-conductance calcium-activated potassium channels (BKCa) is still unclear, but has been recently described a strong relationship with their membrane expression, progerin nuclear levels and the ageing process. In this study, we found that: i) the outward potassium membrane current amplitude and the fluorescence intensity of the BKCa channel probe showed higher values in human dermal fibroblast obtained from patients affected by HGPS if
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder wherein symptoms resembling aspects of aging are manifested at a very early age. It is a genetic condition that occurs due to a de novo mutation in the LMNA gene encoding for the nuclear structural protein lamin A. The lamin family of proteins are thought to be involved in nuclear stability, chromatin structure and gene expression and this leads to heavy effects on the regulation and functionality of the cell machinery. The functional role of the large-conductance calcium-activated potassium channels (BKCa) is still unclear, but has been recently described a strong relationship with their membrane expression, progerin nuclear levels and the ageing process. In this study, we found that: i) the outward potassium membrane current amplitude and the fluorescence intensity of the BKCa channel probe showed higher values in human dermal fibroblast obtained from patients affected by HGPS if
The Michaelis Laboratorys research goal is to dissect fundamental cellular processes relevant to human health and disease, using yeast and mammalian cell biology, biochemistry and high-throughput genomic approaches. Our team studies the cell biology of lamin A and its role in the premature aging disease Hutchinson-Gilford progeria syndrome (HGPS). Other research focuses on the core cellular machinery involved in recognition of misfolded proteins. Understanding cellular protein quality control machinery will ultimately help researchers devise treatments for protein misfolding diseases in which degradation is too efficient or not enough.. Research Areas: biochemistry, cell biology, protein folding, lamin A, aging, genomics, Hutchinson-Gilford progeria syndrome, yeast ...
Hutchinson-Gilford Progeria Syndrome is caused by a single point mutation in the gene encoding lamin A, which forms a protein scaffold on the inner edge of the nucleus that helps maintain chromatin structure and organize nuclear processes such as RNA and DNA synthesis. The mutation creates an alternative splice site that leads to the production of a truncated version of the protein known as progerin. Unlike the full-length protein, progerin does not properly integrate into the nuclear lamina, which disrupts the nuclear scaffold and causes a host of problems ...
Progerias striking features resemble the aging process put on fast-forward and afflicted people rarely live beyond 13 years. Almost all of the patients die from complications of arteriosclerosis-the clogging or hardening of arteries or blood vessels caused by plaques-which leads to heart attack and stroke. Scientists are particularly interested in progeria in the hopes that it might reveal clues to the normal human aging process. However, the disease is exceedingly rare and only 64 children living with progeria are known making access to patients very difficult. Hutchinson-Gilford progeria is caused by a single point mutation in the gene encoding lamin A, which forms a protein scaffold on the inner edge of the nucleus that helps maintain chromatin structure and organize nuclear processes such as RNA and DNA synthesis. The mutation creates an alternative splice site that leads to the production of a truncated version of the protein known as progerin. Unlike the full-length protein, progerin does ...
Progeria is a type of genetic disorder where aging is rapid and premature. There are different genetic disorders with this condition. All of them reflect rapid premature aging in victims. Collectively, they are called progeroid syndromes. But they...
The Saccharomyces Genome Database (SGD) provides comprehensive integrated biological information for the budding yeast Saccharomyces cerevisiae.
Harrys Dad, John. Hayleys sister Charlotte and friends Becky & Tim set off from our house today on the first of 10 marathons in 10 days. I am so proud of my husband who ran an outstanding 29 miles today. The most he has run is 13!! A great big thank you to Charlotte, Becky & Tim for motivating John and keeping him going. Harry is so proud of his dad as I am proud of all of them for running their legs off in support of Harry and Hayley and children with Progeria ...
Over the years, Ive learned three basic principles of plant growth that help me decide where to make a precise pruning cut. First, apical buds (at the tip of a branch) have dominance over lateral buds (on the side of a branch), so the removal of the apical bud results in the growth of lateral buds. When a cut is made just above a bud, that bud will usually become dominant, but if a cut is made mid stem, a flush of growth from a number of buds along the stem may occur ...
If this is an LBR course, and you are eligible for LBR funding, the cost is funded by HEEM - check the list of LBR courses.. If you are funding your own study, the full cost of this module is £700. ...
Five (26%) LMNA mutation carriers with an enlarged and dysfunctional left ventricle were older (67 ± 8 vs. 39 ± 14 years) and had a higher pro-B-type natriuretic peptide level (median 333 ng/l [25th to 75th percentiles: 62 to 1,943] vs. median 66 ng/l [25th to 75th percentiles: 29 to 107]) than LMNA mutation carriers with normal LV dimension and function (both p , 0.05). In all LMNA mutation carriers, PRA and catecholamine levels were within normal range, whereas the plasma aldosterone level was close to the upper normal limit (median 140 pg/ml [25th to 75th percentiles: 75 to 170], reference values: 20 to 180 pg/ml). Eight LMNA mutation carriers (42%) showed myocardial LGE with a patchy (n = 3) or mid wall (n = 5) pattern. In LMNA mutation carriers, LGE was more frequently detected in carriers with LV dysfunction (4 of 5 patients, 80%) compared with those with normal LV dimension and function (4 of 14 [29%], p , 0.05). Myocardial LGE was more common in carriers with first-degree ...
Hi, Im Harry Crowther, Im 18 years old and I have an extremely rare genetic disorder known as Atypical Progeria Syndrome (Non Classical Progeria) whereby I have a defect with the LAMIN A/C gene (LMNA). Though not to be confused with the classical Hutchinson Guilford Progeria Syndrome (HGPS) - both are Premature Aging Disorders. I was diagnosed in the USA aged 7 years old. Together with my Mum I keep this blog. Hope you enjoy my story.. ...
Hayley Okines is just like any girl her age. She loves going to school and spending time with her friends. She goes on sleepovers and loves playing computer games. However, Hayley Okines is not like any other girl her age because Hayley Okines is a 12-year old girl with a 96-year old body (Bates, 2010). She is among the very few who suffer from a rare genetic condition called Hutchinson-Gilford Progeria Syndrome, more commonly known as the "rapid aging" disease…. Read >>. ...
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In 2008, European clinical trials began on twelve children suffering from Progeria. The treatment is based on a combination of two existing molecules: statins (prescribed in the treatment and prevention of atherosclerosis and cardiovascular risks) and aminobisphosphonates (prescribed in to treat osteoporosis and to prevent complications in some forms of cancer). The use of both these molecules aims to chemically alter progerin to reduce its toxicity. However, although this treatment aimed to slow down the development of the disease, it did not reduce the quantities of progerin. To study this aspect, researchers needed to obtain a relevant animal model. An "authentic" Progeria model… To generate a model of this kind, Spanish and French researchers decided to introduce a gene mutation (G609G), equivalent to that identified in humans (G608G), in mice to reproduce the exact pathological mechanism found in the children, with a view to then blocking it. The mice models were created under the ...
After the assessment of the genotoxic potential, further cultivation and investigation regarding carcinogenic transformations of the daughter cells can be performed. The figure shows cells of a down stream culture 384 hours after exposure and subsequent removal of the test compound. The number of nuclei with a brighter fluorescence signal is higher in exposed cells compared to control cells. These alterations of the nuclear morphology correspond to the irreversible condensation of chromatin, known as pyknosis, which is thought to be associated with the carcinogenic transformation of stem cells.. ...
Linc Energy has spud the Umiat No. 23H well. The Australian independent spud the horizontal well at the onshore oil field in the foothills of the Brooks Range Mountains on Feb. 15, the company said Feb. 18. Having drilled the Umiat No. 18 vertical well last winter, Linc is drilling a horizontal well...
Project Title: Genetic modeling of the BANF1 A12T allele in mice and in iPSCs as tools to analyze the craniofacial skeletal defects seen in Nestor-Guillermo Progeria Syndrome. ...
|div class=ep_strongtext|Speakers: Prof. Paul Nolan, Physics Department Liverpool University |/div| |p|Speaker: Professor Paul Nolan|br|Most radioactive nuclei decay by emitting gamma radiation. For a given isotopes the energies of the gamma rays emitted are unique. This means that an accurate measurement of the gamma radiation emitted by an unknown isotope allows it to be identified uniquely. There are many different circumstances when the measurement of gamma radiation gives important information. The energies of gamma rays emitted by an excited nucleus gives information on the neutrons and protons that make up the nucleus and on the nuclear shape (spherical or deformed?). The measurement of the gamma radiation from an unknown source allows radioactive material to be identified and its exact nature determined. This has uses in security applications and following incidents such as Chernobyl or Fukushima. Gamma ray emitting isotopes are also widely used in medical diagnostic using imaging modalities
Researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and the Universidad de Oviedo have discovered a new molecular mechanism involved in the premature development of atherosclerosis in mice with Hutchinson-Gilford progeria syndrome (HGPS). Moreover, the results, published in EMBO Molecular Medicine, identify a potential therapeutic target for this severe genetic disease, which is characterized by the premature onset of cardiovascular disease and early death, usually from a heart attack or stroke, between the ages of 6 and 20 years.. Progeria is very rare genetic disease caused by a mutation in the LMNA gene. The disease affects an estimated 400 people worldwide. HGPS patients show accelerated aging linked to a high risk of cardiovascular disease. In the words of study leader Vicente Andrés, studying this disease "brings us closer to a possible treatment for disease victims and can provide important information about normal physiological aging and the factors that ...
Tom Misteli, Ph.D. is a Swiss-born (Solothurn) cell biologist and pioneer in the field of genome cell biology. Tom Misteli is best known for his work on elucidation of how genomes function in living cells.[Ref 1] While a post-doc at the Cold Spring Harbor Laboratory, New York, United States, he developed methods to visualize proteins in the nucleus of living mammalian cells allowing for the first time to study gene expression in intact cells. His more recent work focuses on the role of genome organization and nuclear architecture on differentiation and disease. His cell biological elucidation of the mechanisms involved in the pre-mature aging disease Hutchinson-Gilford progeria syndrome have revealed novel mechanisms of human aging.[Ref 2] He is an NIH Distinguished Investigator at the National Cancer Institute, NIH, Bethesda, MD, United States and the Director of the NCI Center for Cancer Research at the NIH. He was the Editor-in-Chief of The Journal of Cell Biology (2009-2015) and is the ...
In a study, researchers found that decreased levels of HDL cholesterol may contribute to premature heart disease in children with Hutchinson-Gilford Progeria Syndrome, or Progeria.
Hutchinson‐Gilford progeria syndrome (HGPS, or just plain progeria) is perhaps the best known of the rare but striking accelerated aging conditions caused by genetic mutation. These are not in fact accelerated aging, despite the apparent outcome, but rather DNA repair deficiencies. The water is always muddy when talking about damage and aging, however. Aging is just an accumulation of damage, and progeria is perhaps best thought of as an ordinarily fairly unimportant aspect of aging run amok to create a great deal of damage and dysfunction in cells and tissues.. Over the past decade or so researchers have come to a good understanding of the cause and mechanisms of progeria. An otherwise minor mutation in the LMNA gene leads to the generation of broken forms of a vital cellular structural protein, lamin A, and things go downhill from there: a progeria patients cells are greatly malformed and perform poorly at the most crucial of their tasks. Interestingly, dysfunctional forms of this protein ...
Primary cilia arise from the centrosomes of quiescent or post‐mitotic cells, and serve as sensory organelles that communicate mechanical and chemical stimuli from the environment to the interior of the cell
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Definition of periodic breathing in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is periodic breathing? Meaning of periodic breathing as a legal term. What does periodic breathing mean in law?
Normally the meristematic cells are oval, polygonal or rectangular in shape. Meristemetic tissue cells have a large nucleus ... Cells in these tissues are roughly spherical or polyhedral, to rectangular in shape, and have thin cell walls. New cells ... Each cell contains a dense cytoplasm and a prominent nucleus. Dense protoplasm of meristematic cells contains very few vacuoles ... Most classification schemes combine a description of the cell-shape in the upper layer of the epithelium with a word denoting ...
The cell shape is variable but is mostly obovoid to ellipsoid. The lateral cell margins maybe somewhat angular leading to a ... The nucleus typically lies in the posterior half of the cell. The mitochondria have tubular cristae. Organelles called ... Provided with a nucleus and contracting vesicles. - Carter, 1865 In 1917, it was classified as being one of the "simplest and ... Members of this genus are known to reproduce asexually through cell division. Whether sexual reproduction occurs is currently ...
Platelets do not have a cell nucleus. They are disc-shaped, and are 1.5 to 3 micrometers in diameter. The body does not have a ... A platelet is a cell fragment that circulates in the blood. Platelets are involved in hemostasis through the making of blood ...
Gametocytes are "kidney-shaped" and are smaller than the host cell nucleus. This species is found in Brazil in the Amazon area ... Infection does not enlarge or distort the host red blood cells. Each infected cell generally yields 4 to 8 new merozoites. ... Blood stages of the parasite are described to occupy at one pole of the host cell. ...
... s are star-shaped (stellate) cells with oval nuclei. The development of the vitreous is organized into three stages: ... Hyalocytes, also known as vitreous cells, are cells of the vitreous body, which is the clear gel that fills the space between ... Sense Organs". Histology and cell biology : examination and board review (5th ed.). Stamford, Conn.: Appleton & Lange. ISBN 978 ... the basic components of the vitreous begin to form from the mesenchyme embryonic cell layer. Hyalocytes likely develop from the ...
"Shape and Texture Indexes, Application to Cell Nuclei Classification". Pattern Recognition and Artificial Intelligence (IJPRAI ... Application to Cell Nuclei Classification". Pattern Recognition and Information Processing (PRIP): 140-145. [1] Guillaume ... 3] Guillaume Thibault; Izhak Shafran (2016). "Fuzzy Statistical Matrices for Cell Classification". arXiv:1611.06009 [cs.CV]. ...
As single cells, they reproduce asexually by budding. Their nerves have no cell body and no nuclei; nothing to separate them ... The brain is large, shaped long and narrow, and is encased in a bony cage. The skull is one end of this jointless, flexible, ... Niven's works describe Bandersnatchi as one giant cell with long chromosomes as thick as a human finger, rendering them ... twice the size of an Apatosaurus with a slug-like shape and completely white, slick skin. A sauropod-like neck, with no head, ...
Additionally, the nuclei of anaplastic cells are usually unnaturally shaped or oversized. Cells can become anaplastic in two ... in size and shape). Anaplastic cells display marked pleomorphism. The cell nuclei are characteristically extremely ... Anaplastic cells have lost total control of their normal functions and many have deteriorated cell structures. Anaplastic cells ... Giant cells - considerably larger than their neighbors - may form and possess either one enormous nucleus or several nuclei ( ...
The schizonts and gametocytes caused hypertrophy and distortion of host cell and nucleus. The nucleus may be displaced. Pigment ... The schizonts are usually polar in position, rounded in shape, and may produce over 100 merozoites. Large schizonts visibly ...
Gametocytes, while varying in shape tend to be round or oval, do not exceed the size of the nucleus and stick to it. The type ... Haemamoeba Mature schizonts are larger than the host cell nucleus and commonly displace it. Gametocytes are large, round, oval ... The schizonts apically or lateroapically placed and are rounded or irregularly shaped. The host nucleus may be tilted. The type ... Giovannolaia Schizonts contain plentiful cytoplasm, are larger than the host cell nucleus and frequently displace it. They are ...
The asexual stages rarely disturb the host cell. The gametocytes may distort the cell or displace the nucleus. Mature schizonts ... The mature gametocytes vary in size: 5.0 - 12.0 x 2.0 - 6.0 micrometres and tend to be elongated in shape. This species is ... Schizonts tend to lie lateral to the nucleus. ...
... where chromosomes divide within an intact cell nucleus.[8] Most animal cells undergo a shape change, known as mitotic cell ... Related cell processes[edit]. Cell rounding[edit]. Cell shape changes through mitosis for a typical animal cell cultured on a ... In animal cells, a cell membrane pinches inward between the two developing nuclei to produce two new cells. In plant cells, a ... Onion (Allium) cells in different phases of the cell cycle enlarged 800 diameters.. a. non-dividing cells. b. nuclei preparing ...
Each individual thallus consists of a single cell with a single nucleus. There is a holdfast where the alga is attached to the ... The thallus is emerald green and cup-shaped, or occasionally flattened, with twenty two to thirty rays. The stipe is up to 7 ... Evidence of a polypeptide in whole cells and anucleated cells". Toxicological & Environmental Chemistry. 55 (1-4): 11-18. doi: ... If the plant is broken in two pieces, each is able to survive and regenerate new parts, even the one that lacks a nucleus, ...
The cells have multiple nuclei and many chloroplasts, each with a pyrenoid. The cells of some species are very large, up to 2 ... In some species the colonies maintain a symmetrical shape but in others they do not. Some species have been extensively used ...
The infected cells are hypertrophied and distorted and their nuclei are displaced. The schizonts are polymorphic and contain 12 ... nuclei when apparently mature. Prematuration sexual stages may be irregularly shaped and larger than mature gametocytes. The ...
... they are spindle-shaped, and each possesses a large spherical nucleus near the middle of the cell. ... The bud is formed by two kinds of cells: supporting cells and gustatory cells. ... Taste buds contain the taste receptor cells, which are also known as gustatory cells.[1] The taste receptors are located around ... These are located on top of the taste receptor cells that constitute the taste buds. The taste receptor cells send information ...
... to fit the small available volumes of the cell. In eukaryotes, DNA is located in the cell nucleus, with small amounts in ... The structure of DNA is dynamic along its length, being capable of coiling into tight loops, and other shapes. In all species ... As it resided in the nuclei of cells, he called it "nuclein". In 1878, Albrecht Kossel isolated the non-protein component of " ... Cell division is essential for an organism to grow, but, when a cell divides, it must replicate the DNA in its genome so that ...
They tend to encircle the nucleus and the host cell tends to become oval in shape. Male gametocytes measure 20 micrometres x 2 ... The host cells are not altered in either shape or size by the asexual stages of the parasite. Pigment is rare and a vacuole may ...
Cell nucleus#Splicing speckles are subnuclear structures that are enriched in pre-messenger RNA splicing factors Berezney, ... They usually appear as irregularly shaped structures that vary in size and number. They can be observed by immunofluorescence ... An interchromatin granule is a cluster in the nucleus of a mammal cell which is enriched in pre-mRNA splicing factors. ... Interchromatin granules are located in the interchromatin regions of the mammalian Cell nuclei. ...
... there is often an indentation in the area that faces the nucleus of the cell. The Pick bodies are able to be labeled by N- ... Not only do these tangles have the 3R tau protein predominately, they are characteristically shaped with a round body; ... A buildup of Aβ within cells causes inflammation, leading to cell destruction by the immune system. Proteins associated with ... including the mossy fibers as well as the monodendritic brush cells in the granule cell layer, and generating output signals, ...
The multiple layers of parabasal cells are polyhedral in shape with prominent nuclei.[6] ... clear cell nucleus Frequent glycogen storage, thickened cell margins and decentralized cell nucleus; Predominant cell type in ... As a result of cell aging, cells with shrunken, seemingly foamy cell nuclei (intermediary cells ) develop from the parabasal ... CellsEdit. cell type Features Diameter Nuclei Notes basal cell round to cylindrical, narrow basophilic cytoplasmic space 12-14 ...
Microglial cells are small relative to macroglial cells, with changing shapes and oblong nuclei. They are mobile within the ... ependymal cells and microglia, and in the peripheral nervous system glial cells include Schwann cells and satellite cells. The ... These PNS glia include Schwann cells in nerves and satellite glial cells in ganglia. Current research involving glial cells in ... In the peripheral nervous system (PNS), glial cells known as Schwann cells promote repair. After axonal injury, Schwann cells ...
The schizonts produce up to 65 nuclei and cause host cell hypertrophy and distortion. The gametocytes are spindle-shaped. The ... female gametocyte often has a subterminal nucleus. This species was described in Kenya, Africa. The only host for this species ...
inner ear: Hair cells → Spiral ganglion → Cochlear nerve VIII →. *pons: Cochlear nucleus (Anterior, Dorsal) → Trapezoid body → ... named for the spiral shape it shares with the cochlea. These central axons exit the cochlea at its base and form a nerve trunk ... the posteroventral cochlear nucleus (PVCN). Each of the three cochlear nuclei are tonotopically organized. The axons from the ... The central axons form synaptic connections with cells in the cochlear nucleus of the brainstem. ...
Infected cells have large numbers of abnormal chloroplasts, mitochondria and hypertrophied nuclei. Cells of CPsV-EG infected ... which are displaced toward nucleus periphery along the nuclear envelope. Sometimes nucleolus appear abnormally shaped. ... Crystal idioblast (CI) containing cells are lacking in the palisade layer and protrude into the epidermis. The oil glands are ... The vein endings consist of a single trachoid strand of elongated parenchyma cells enclosed by the bundle sheath compared with ...
Leptin targets the receptors on the arcuate nucleus and suppresses the secretion of MCH and orexin. The arcuate nucleus also ... The brain detects insulin in the blood, which indicates that nutrients are being absorbed by cells and a person is getting full ... Eldredge, K. L.; Agras, W. S. (1994). "Weight and Shape Overconcern and Emotional Eating in Binge Eating Disorder". ... When the glucose levels of cells drop (glucoprivation), the body starts to produce the feeling of hunger. The body also ...
For the roughly two meters of DNA to fit into a cell nucleus, it must be packed into chromatin. This tight packing within the ... The genome in three dimensions folds up, forming loops and other shapes, to fit inside the nucleus. Photo credit: Darryl Leja ... "In any given cell type, you may have 30,000-50,000 sites in the genome that modulate gene expression. How do we even think ... "An important aspect of the ENCODE Project is to identify collections of cell types for use in creating an incredibly detailed ...
We study the problem of segmenting multiple cell nucle-i from GFP or Hoechst stained microscope images with a shape prior. This ... cell tracking), but also prevent robust statistical analysis (e.g. modeling of fluores-cence distribution). We therefore ... problem is encountered ubiquitously in cell biology and developmental biology. Our work is mo-tivated by the observation that ... segment dense cell nucleus shape prior rand index increase prevent robust statistical analysis corresponding energy term ...
Modeling nuclear volume and shape in the adherent state. The shape of the nucleus in adherent cells resembles a flat pancake. ... reversing the shape changes seen in Fig. 2. Scale bars: 10 μm. (B) Volume change in the nucleus of a MEF cell during cell going ... the nucleus evolved from a flat pancake shape to a more rounded shape. Eventually, as the cell fully detached, the nuclear ... Volume regulation and shape bifurcation in the cell nucleus. Dong-Hwee Kim, Bo Li, Fangwei Si, Jude M. Phillip, Denis Wirtz, ...
... Wählby, Carolina ... Algorithms for segmentation of 2D and 3D images of cell nuclei in tissue by combining intensity, shape, and gradient ... As a final step, clusters of nuclei are separated, based on the shape of the cluster. The number of input parameters to the ... Automation/methods, Cell Nucleus/*ultrastructure, Cervix Neoplasms/*pathology/ultrastructure, Female, Humans, Image Processing ...
When cells are missing that protein, known as Wash, nuclei lose their classic plump shape and become wrinkled and puckered. ... Nuclei pucker in the natural aging process and in certain diseases including progeria, a rare and fatal genetic disorder that ... a special compartment within cells that houses and controls genetic information. ... Scientists at Fred Hutchinson Cancer Research Center have found a protein that helps shape the nucleus, ...
Pels, E; Groot, J W.; Mullink, R; Unnik, J A.; Otter, D W.; and Exudate, F O., "Cells with ring-shaped nuclei." (1980). Subject ...
The lens-shaped nucleus in this cell is typical of nuclei in the onion epidermis. It is squeezed between the central vacuole (V ... 1993). Basket-shaped structures formed by F-actin in the nuclei of elongating cells of Nicotiana tabacum. Can. J. Bot. 71, 725- ... The nuclei of onion epidermal cells deviate from a lenslike shape in two ways-through the formation of nuclear grooves and ... Tobacco NT1 Nuclei Contain Invaginations and Grooves That May Originate during Cell Division. The nuclei of tobacco NT1 ...
Cell small, spindle-shaped, 1 oval nucleus. *Can divide, can regenerate. *Actin & myosin organized so no striations ... Specialized cardiac muscle cells = pacemaker cells= establish regular rate of contraction. *Nervous system can alter rate of ... Epithelial surfaces kept moist at all times: lubricated by goblet cells or multicellular glands or by exposure to fluids (semen ... Consists of extensive areas of loose connective tissue bounded by a superficial layer of squamous or cuboidal cells ...
"Typically a cell like this is elliptical in shape. But these were in big clusters; giant cells with multiple nuclei. A very ... cells known as circulating endothelial cells (CEC). Typically these cells act like Saran Wrap - they are tightly banded ... On the left are normal, healthy cells that line the coronary artery -- also known as circulating endothelial cells (CEC). On ... Topol compared the CECs to a control group of 44 healthy people, all of which had normal CEC counts and shapes. Because of the ...
This method involves technology to separate nucleated cells from red blood cells, which lack a nucleus. All nucleated cells, ... indicating the cell is not of hematopoietic origin; and are often larger cells with irregular shape or subcellular morphology.[ ... To obtain vital cells and to reduce stress of those cells, blood cells are prepared by only one centrifugation step and ... Only vital, propidium excluding EpCAM positive cells are counted as potential tumor cells. Only living cells can grow into ...
For instance, nuclei in brain cells tend to be soft and pliable while those in bone cells ... ... The changing shape of an atomic nucleus. The nucleus of an atom can have different shapes that co-exist. European scientists ... Putting the squeeze on a cells nucleus. Nuclear membranes protect genes-lifes most precious cargo-but little is known about ... A cells cap of bundled fibers could yield clues to disease (w/ Video). It turns out that wearing a cap is good for you, at ...
Chromatin maintains nuclear mechanical stability and shape in coordination with lamins and the cy... ... The cell nucleus encloses, organizes, and protects the genome. ... Cell Nucleus Shape. The quality of surface form or outline of ... Summary of "Chromatins physical properties shape the nucleus and its functions.". The cell nucleus encloses, organizes, and ... Iowa/Nucleus 10/10 mm and Nucleus Freedom Feasibility Study. The purpose of this study is to evaluate whether the Iowa/Nucleus ...
... and the spinal cord with Purkinje cell output from cerebellar cortex and provide the major output of the cerebellum. Despite ... The deep cerebellar nuclei (DCN) integrate inputs from the brain stem, the inferior olive, ... Cell Shape / physiology * Cerebellar Nuclei / cytology * Cerebellar Nuclei / metabolism* * Dendrites / metabolism * Dendrites ... Morphological and electrophysiological properties of GABAergic and non-GABAergic cells in the deep cerebellar nuclei J ...
B) Size and Shape of the Cells Nucleus. The shape and size of the nucleus of a cancer cell are often not normal. The nucleus ... A) Shape and Size of the Cells. It has been observed that the overall shape and size of cells in the tissues are mostly normal ... i) Nucleus Area (A). The nucleus area can be represented by nucleus region containing total number of pixels; it is shown in ... The nuclei of cancer cells are larger than the normal cells and deviated from the centre of the mass. The nucleus of cancer ...
Title: Unit 38 cells, tissues, organs and organ systems, Author: Umran Naeem, Name: Unit 38 cells, tissues, organs and organ ... Muscle cells. Red blood cells contain haemoglobin, have a biconcave shape and no nucleus. They carry oxygen from the lung ... All animal and plant cells have cell parts or organelles in common, for example the nucleus. Plants cells contain unique cell ... Cells can have a very wide range of f_________ in the human body from skin cells, blood cells, muscle cells to nerve cells. ...
Phys.org) -A crucial step toward skin cancer may be changes in the genes that control cell shape, report a team of scientists ... Cells lacking nuclei struggle to move in 3-D environments. January 20, 2018 University of North Carolina Lineberger ... In contrast to conventional wisdom, other shapes and "intermediate" forms were rare, suggesting genes that control cell shape ... When turned off, virtually all cells became elongated or large and rounded, two shapes that can help cancerous cells escape ...
Nuclear shaping is a critical event during sperm development as demonstrated by the incidence of male infertility associated ... with abnormal sperm ad shaping. Herein, we demonstrate that mouse and rat spermatids assemble in the subacrosomal space a cyt ... Cell Nucleus / metabolism*, ultrastructure. Cloning, Molecular. Fluorescent Antibody Technique. Gene Library. Humans. Keratin-5 ... Anchorage of the acroplaxome to the gradually shaping nucleus is not disrupted by hypotonic treatment and brief Triton X-100 ...
... male reproductive cell, produced by most animals. With the exception of nematode worms, decapods (e.g., crayfish), diplopods (e ... The membrane of the sperm cell then fuses with that of the egg, and the sperm nucleus is conveyed into the egg. ... The head of the sperm varies in shape for each animal species. In humans it is flattened and almond-shaped, four to five ... cell: Meiosis. Gametes such as ova, sperm, and pollen begin as germ cells, which, like other types of cells, have two copies of ...
... as with many cells, cell shape is critical to the functions it can perform. However, little is known about how cells regain ... researchers report new insights about the underlying drivers that help cells heal and maintain their shape. ... proper shape after an injury. In a new study being presented at The Allied Genetics Conference in Orlando, Fla., ... In the second phase, the cells nucleus, containing its DNA, changes shape. Lin observed that this change in nucleus shape is ...
The number and shape of chromosomes in the nucleus of a cell. Scientists prepare karyotypes by staining cell nuclei, placing ... See also: Cells. karyotype. Past participle: karyotyped. Gerund: karyotyping. Imperative. Present. Preterite. Present ... karyotype - the appearance of the chromosomal makeup of a somatic cell in an individual or species (including the number and ... Biology) the appearance of the chromosomes in a somatic cell of an individual or species, with reference to their number, size ...
Numerous pyramidally shaped neurons are present within perineuronal spaces. These cells have large vesicular nuclei. The small ... cells seen only as nuclei are glial cells. The stringy pink background is the neuropil. Histology image descriptions and ...
... the position of the nucleus, and the number of vacuoles. ... Some of the main differences between plant and animal cells ... Plant cells have a rectangular shape and are larger.. The Cell Wall. Animal cells do not contain cell walls as one of the ... Animal cells look very different to plant cells. They are typically smaller than plant cells, with a roundish shape which is ... Cell wall - different from a membrane by being found only in plant cells where it encompasses the cell membrane. The cell wall ...
Untreated nuclei (left) show abnormal shape. Methylene blue-treated nuclei (right) show normal, rounded shape. Image: Kan Cao ... which sits just inside the cells nucleus, under the nuclear membrane. Healthy cells snip off a small piece of each new lamin A ... The team found that methylene blue reverses the damages to both the nucleus and mitochondria in progeria cells remarkably well ... When we looked at the treated cells, it was hard to tell that they were progeria cells at all. Its like magic." - Kan Cao, UMD ...
Cells selected for injection contained normally shaped nuclei. The mutant protein was rapidly transported into the nucleus and ... HGPS cell nuclei frequently display irregular shapes (6). Similar nuclear shape abnormalities have been reported in patients ... To analyze the changes in nuclear shape, we measured the perimeter and the area of nuclei in both AG09602B and HGADFN003 cells ... In contrast, attempts to restore the normal shape of highly lobulated nuclei by injecting WT LA into late-passage HGPS cells ...
Leiomyosarcoma: spindle cells with cigar-shaped nuclei; actin and desmin+; MDM and CDK4-. ... Renal Cell Carcinomas * Clear Cell Renal Cell Carcinoma * Clear Cell Renal Cell Carcinoma: Fuhrman Nuclear Grade ... Renal Cell Carcinomas * Clear Cell Renal Cell Carcinoma * Clear Cell Renal Cell Carcinoma: Fuhrman Nuclear Grade ...
  • With this funding, ENCODE will expand the scope of these efforts to include characterization centers, which will study the biological role that candidate functional elements may play, and develop methods to determine how they contribute to gene regulation in a variety of cell types and model systems. (genome.gov)
  • Now, a team of investigators from the Northwestern University Center for Cancer Nanotechnology Excellence (Northwestern CCNE) has developed star-shaped nanoparticle that can deliver a drug directly to a cancer cell's nucleus an important feature for many potential anticancer therapies. (nanowerk.com)
  • The Northwestern CCNE team, led by Teri Odom, also reported that it was able to directly image at nanoscale dimensions how nanoparticles interact with a cancer cell's nucleus. (nanowerk.com)
  • They are attracted to a protein on the cancer cell's surface that conveniently shuttles the nanostars to the cell's nucleus. (nanowerk.com)
  • Inside the cell's nucleus, the double helix folds up in myriad loops and twists. (flipboard.com)
  • Most often the Golgi apparatus and the centrioles in an SGC are found in a region very close to the cell's nucleus. (wikipedia.org)
  • This is in contrast to most other methods for cell analysis, which do not account for inter-cellular variation. (diva-portal.org)
  • The other dichotomy is by lineage: Myeloid cells (neutrophils, monocytes, eosinophils and basophils) are distinguished from lymphoid cells (lymphocytes) by hematopoietic lineage ( cellular differentiation lineage). (wikipedia.org)
  • They also do three major things needed for the cell to work properly which are: modify transfers of RNA's, sense cellular stress, and signal recognition particles. (prezi.com)
  • Previous studies in a type 1/insulin-deficient diabetic embryopathy model demonstrated that oxidative stress, endoplasmic reticulum (ER) stress, and cellular stress-induced cell apoptosis ( 8 - 16 ) are causative events in NTD formation. (diabetesjournals.org)
  • Carbon dioxide is produced by cells as they undergo the processes of cellular respiration (particularly the Kreb's Cycle). (wikibooks.org)
  • Formed cellular elements (red and white blood cells, and platelets) which combine to make the remaining 45% of blood volume. (wikibooks.org)
  • formed cellular elements (red and white blood cells, and platelets). (wikibooks.org)
  • The nucleus is the largest cellular organelle in animal cells. (wikipedia.org)
  • In biology, tissue is a cellular organizational level between cells and a complete organ. (wikipedia.org)
  • Those cells are modified and grow bigger (hypertrophy) without cellular division. (wikipedia.org)
  • Surrounding cells will suffer hyperplasia and start cellular division wildly. (wikipedia.org)
  • citation needed] Hammerling's results showed that the nucleus of a cell contains the genetic information that directs cellular development. (wikipedia.org)
  • Mycoplasmae may induce cellular changes, including chromosome aberrations, changes in metabolism and cell growth. (wikipedia.org)
  • The connections between the large cell bodies and smaller features could not be observed, and it was possible that neurofibrils would stand as an exception to cell theory as non-cellular components of living tissue. (wikipedia.org)
  • Anaplasia (from Ancient Greek: ἀνά ana, "backward" + πλάσις plasis, "formation") is a condition of cells with poor cellular differentiation, losing the morphological characteristics of mature cells and their orientation with respect to each other and to endothelial cells. (wikipedia.org)
  • Anaplasia is the most extreme disturbance in cell growth encountered in the spectrum of cellular proliferations. (wikipedia.org)
  • They have two cellular layers: the top epitheloid layer is made of ciliated "cover cells" flattened toward the outside of the organism, and the bottom layer is made up of cylinder cells that possess cilia used in locomotion, and gland cells that lack cilia. (wikipedia.org)
  • Brain mapping is further defined as the study of the anatomy and function of the brain and spinal cord through the use of imaging (including intra-operative, microscopic, endoscopic and multi-modality imaging), immunohistochemistry, molecular & optogenetics, stem cell and cellular biology, engineering (material, electrical and biomedical), neurophysiology and nanotechnology. (wikipedia.org)
  • Within the nucleus, the DNA molecules are found in "looped arrangements" that mimic the circular DNA observed in many prokaryotes. (encyclopedia.com)
  • Is responsible for the chemical changes of small molecules taken in by the cell. (prezi.com)
  • The molecules inside cells that carry genetic information and pass it from one generation to the next. (cancer.gov)
  • Nucleoplasm : Contain a variety of particles with other molecules involved in maintenance and development of the cell. (scribd.com)
  • 1 IL-10 inhibits proliferation and cytokine production by T cells and down-regulates production of inflammatory cytokines as well as expression of costimulatory molecules on monocytes/macrophages. (bloodjournal.org)
  • 5 , 6 In addition to IL-10, it has been shown that other cytokines, such as IFN-α, 6 or inhibitory and costimulatory molecules, such as ICOS-L 7 and CD46, 8 can promote Tr1 cell differentiation. (bloodjournal.org)
  • Oxygen is carried in the blood bound to hemoglobin molecules within red blood cells. (wikibooks.org)
  • In response to tissue damage, fibrinogen makes fibrin threads, which serve as adhesive in binding platelets, red blood cells, and other molecules together, to stop the blood flow. (wikibooks.org)
  • The fragments can be incorporated into MHC molecules and then trafficked to the cell surface of monocytes (and macrophages and dendritic cells). (wikipedia.org)
  • Current research on fibronectin, other ECM molecules, and integrins is revealing the influential role of the ECM in the lives of cells. (wikipedia.org)
  • Each cell has many DNA molecules, but because cells are very small and DNA molecules are long, the DNA is packaged very tightly in each cell. (wikipedia.org)
  • However, a lack of particular co-stimulated molecules that aid in the way antigens react with lymphocytes can impair the natural killer cells' function, ultimately leading to cancer. (wikipedia.org)
  • If a cell is under stress, turning into tumors, or infected, molecules including MIC-A and MIC-B are produced to put on the surface of the cell. (wikipedia.org)
  • They are short-lived and highly motile, or mobile, as they can enter parts of tissue where other cells/molecules cannot. (wikipedia.org)
  • Parkhurst and her team found that Wash-deficient nuclei shrink to about two-thirds of their natural size. (fredhutch.org)
  • Parkhurst and her colleagues found that not only do nuclei crumple when Wash is missing, but the genetic information inside also falls into disarray. (fredhutch.org)
  • Recently, however, the nuclei of animal cells have been found to show considerable spatial and structural organization at the chromosomal level. (plantcell.org)
  • The blood test involves examining specific cells from a person's coronary artery, which were found to be abnormally large and misshapen in the days before an impending heart attack. (foxnews.com)
  • In contrast to the rather homogeneous population of GAD-positive cells, the GAD-negative cells were found to consist of two distinct populations as defined by cell size and electrophysiological features. (nih.gov)
  • We found that by altering the way the cells are grown to better mimic conditions in a living organism , gene expression could have a profound impact on cell shape," said Zheng Yin, the paper's lead author and a postdoctoral fellow at the Department of Systems Medicine and Bioengineering of The Methodist Hospital Research Institute (TMHRI). (phys.org)
  • Under normal conditions, each hemocyte was found to take on just one of five distinct shapes about 98 percent of the time. (phys.org)
  • These cell walls aren't found in cells within the animal kingdom - we'll look at that in just a bit. (worldatlas.com)
  • The granule cells, produced by the rhombic lip , are found in the granule cell layer of the cerebellar cortex . (wikipedia.org)
  • Using an electron microscope, Odom and her team found their drug loaded nanoparticles dramatically change the shape of the cancer cell nucleus. (nanowerk.com)
  • I found nuclein in every cell type I tested. (dnalc.org)
  • DNA - deoxyribonucleic acid - is found mainly in the nucleus. (dnalc.org)
  • A cell wall is only found in a plant cell. (prezi.com)
  • Found in both plant and animal cells, is the endoplasmic reticulum, which is clear tubes that travel throughout all parts of the cell. (prezi.com)
  • These are found in the plant cell and in the animal cell. (prezi.com)
  • The mitochondrion is a pill shaped organelle that is found in both plant and animal cells. (prezi.com)
  • They are found in both plant and animal cells. (prezi.com)
  • A chloroplast is a small pill-shaped organelle found only in plants. (prezi.com)
  • A population of stem cells found on the dorsal aorta which is known as the AGM. (brainscape.com)
  • At 2-8 weeks, primitive nucleated erythroid cells are found in the yolk sac (contain haemoglobin but don't mature to fully developed RBCs. (brainscape.com)
  • White cells are found in the buffy coat , a thin, typically white layer of nucleated cells between the sedimented red blood cells and the blood plasma . (wikipedia.org)
  • Most DNA is found inside the nucleus of a cell, where it forms the chromosomes. (cancer.gov)
  • Renal cell cancer (also called kidney cancer or renal cell adenocarcinoma) is a disease in which malignant ( cancer ) cells are found in the lining of tubules (very small tubes) in the kidney . (cancer.gov)
  • It does not cover information about sporadic renal cell cancer or somatic mutations found during tumor sequencing . (cancer.gov)
  • The ER is a network of membranes found throughout the whole body of the cell which is connected to the nucleus. (prezi.com)
  • Furthermore, spindle-shaped nuclei were found in differentiated root epidermal and cortex tissue, oriented along the long axis of the cell, and rod-like nuclei were located within vascular tissues. (plantcell.org)
  • The DNA is found in the nucleus of all cells. (s-cool.co.uk)
  • Digestive sacks - the main point of digestion, these are only found in animal cells. (wikibooks.org)
  • The cell division, that is found in most non-reproductive cells. (wikibooks.org)
  • Figures 2-8, together with Figure 12, are higher magnification photomicrographs of phycobiont and mycobiont cells found in the algal layer of certain lichens, which grow at the Creation Research Society's Van Andel Creation Research Center (Chino Valley, Arizona). (creationresearch.org)
  • found together with fungal cells in the lichen Caloplaca sp. (creationresearch.org)
  • Forms spindle fibers, aids in cell division, and only found in animal cells? (sporcle.com)
  • The posterior thoracic nucleus, (Clarke's column, column of Clarke, dorsal nucleus, nucleus dorsalis of Clarke) is a group of interneurons found in the medial part of lamina VII, also known as the intermediate zone, of the spinal cord. (wikipedia.org)
  • Pick bodies are almost always found in several places in the brain, including the dentate gyrus, the pyramidial cells of the CA1 sector and subiculum of the hippocampus, and the neocortex as well as a plurality of other nuclei. (wikipedia.org)
  • Some, however, are found in the interior of the bud between the gustatory cells. (wikipedia.org)
  • These cells are found in all regions of the brain and spinal cord. (wikipedia.org)
  • The vast majority of granule cell axonal synapses are found on the parallel fibers. (wikipedia.org)
  • Acetabularia is a genus of green algae, specifically of the Polyphysaceae family, Typically found in subtropical waters, Acetabularia is a single-celled organism, but gigantic in size and complex in form, making it an excellent model organism for studying cell biology. (wikipedia.org)
  • Mycoplasma species are often found in research laboratories as contaminants in cell culture. (wikipedia.org)
  • A more recent technique based on this method is Hoffmann's modulation contrast, a system found on inverted microscopes for use in cell culture. (wikipedia.org)
  • Platelets are found only in mammals, whereas in other animals (e.g. birds, amphibians) thrombocytes circulate as intact mononuclear cells. (wikipedia.org)
  • Max Schultze in 1865 described what he called "spherules", which he noted were much smaller than red blood cells, occasionally clumped, and were sometimes found in collections of fibrin material. (wikipedia.org)
  • Leydig cells, also known as interstitial cells of Leydig, are found adjacent to the seminiferous tubules in the testicle. (wikipedia.org)
  • These inclusions have no known function, are found in less than half of all Leydig cell tumors, but serve to clinch the diagnosis of a Leydig cell tumor. (wikipedia.org)
  • Lateral electrical surface stimulation therapy has been found to destroy Leydig cells. (wikipedia.org)
  • Langhans giant cells (also known as Pirogov-Langhans cells) are large cells found in granulomatous conditions. (wikipedia.org)
  • Langhans cells are often found in transbronchial lung biopsies or lymph node biopsies in patients suffering from sarcoidosis. (wikipedia.org)
  • Goblet cells are typically found in the respiratory, reproductive and gastrointestinal tracts and are surrounded by stratified squamous cells. (wikipedia.org)
  • Goblet cells are found scattered among the epithelial lining of organs, such as the intestinal and respiratory tracts. (wikipedia.org)
  • In mucicarmine stains, deep red mucin is found within goblet cell bodies. (wikipedia.org)
  • An intestinal gland from the human intestine with goblet cells visible Goblet cell in ileum Section of mouse intestine, mucus of goblet cells in blue Goblet cells in large intestine The main role of goblet cells is to secrete mucus in order to protect the mucous membranes where they are found. (wikipedia.org)
  • Raphides are needle-shaped crystals of calcium oxalate as the monohydrate or calcium carbonate as aragonite, found in more than 200 families of plants. (wikipedia.org)
  • Raphides are found in specialized plant cells or crystal chambers called idioblasts. (wikipedia.org)
  • They are a form of T-lymphocytes that has been mutated This atypical form of T-lymphocytes contains T-cell receptors on the surface and is found in both the dermis and epidermis layers of the skin. (wikipedia.org)
  • Lutzner cells are more predominant in Mycosis Fungoides, but are also found in Sézary Syndrome. (wikipedia.org)
  • The body tissues are composed of numerous types of cell, including those found in muscles, nerves and skin. (wikipedia.org)
  • The absence of this structure, which is otherwise to be found in all animals except the sponges, can be explained in terms of function: a rigid separating layer would make the amoeboid changes in the shape of Trichoplax adhaerens impossible. (wikipedia.org)
  • Between them are found unciliated gland cells thought to be capable of synthesizing digestive enzymes. (wikipedia.org)
  • This giant cell is often found in tissue because of medical devices, prostheses, and biomaterials. (wikipedia.org)
  • Satellite glial cells are the principal glial cells found in the peripheral nervous system, specifically in sensory, sympathetic, and parasympathetic ganglia. (wikipedia.org)
  • These domains (few to 20) were found to form a donut shaped structure when cells were starved of amino acids. (wikipedia.org)
  • Acroplaxome, an F-actin-keratin-containing plate, anchors the acrosome to the nucleus during shaping of the spermatid head. (biomedsearch.com)
  • The acroplaxome may also provide a mechanical planar scaffold modulating external clutching forces generated by a stack of Sertoli cell F-actin-containing hoops encircling the elongating spermatid nucleus. (biomedsearch.com)
  • This pyramid shape is achieved through tubulin and actin in the apical portion of the cell which constricts as they move. (wikipedia.org)
  • When turned off, virtually all cells became elongated or large and rounded, two shapes that can help cancerous cells escape confinement, travel blood vessels, and infiltrate healthy tissues. (phys.org)
  • Bakal added, "The cells have to become rounded to travel through the bloodstream or invade soft tissues such as the brain, but they take on an elongated shape to travel through harder tissues like bone. (phys.org)
  • The parapharyngeal space is an inverted pyramid-shaped area of the deep tissues of the neck. (thefreelibrary.com)
  • For example, Arabidopsis behaves genetically as a diploid, but vegetative adult tissues are composed of a mixture of cells with nuclei ranging in ploidy levels from 2C (where C = haploid genome complement) to 64C. (plantcell.org)
  • Cells and tissues are analyzed in the laboratory to look for the presence or effects of diseases, including cancer. (cancer.ca)
  • At 0 and 0.5 h postenvenomation, neuronal cells in brain tissues from healthy and envenomated flies appeared virtually identical in appearance. (hindawi.com)
  • Knowing the dynamics of such mechanisms and of chemical processes in cells is decisive to understand important biological aspects such as cell motion and the development of cell tissues. (ptb.de)
  • Cell junctions are well-employed in epithelial tissues. (wikipedia.org)
  • Summary showing different epithelial cells/tissues and their characteristics. (wikipedia.org)
  • In general, simple epithelial tissues are classified by the shape of their cells. (wikipedia.org)
  • The epithelial tissues are formed by cells that cover the organ surfaces such as the surface of skin, the airways, the reproductive tract, and the inner lining of the digestive tract. (wikipedia.org)
  • Monocytes circulate in the bloodstream for about one to three days and then typically move into tissues throughout the body where they differentiate into macrophages and dendritic cells. (wikipedia.org)
  • Theodor Schwann proposed in 1839 that the tissues of all organisms are composed of cells. (wikipedia.org)
  • Schwann was expanding on the proposal of his good friend Matthias Jakob Schleiden the previous year that all plant tissues were composed of cells. (wikipedia.org)
  • This prevents oxygen from reaching the body's tissues and can cause a loss of red blood cells. (wikipedia.org)
  • Once the vector bites a new host, the sporozoites enter the blood stream and invade endothelial cells of blood vessels within various tissues including those of the lung, liver and spleen. (wikipedia.org)
  • Carcinoma, the majority of cancer cells are epithelial in origin, beginning in the membranous tissues that line the surfaces of the body. (wikipedia.org)
  • The white spots are single cells called trophozoites or trophonts, which feed on the tissues of the host and may grow to 1 mm in diameter. (wikipedia.org)
  • Infection causes transformation and hypertrophy (approximately 1000x) of cells in the dermis, forming grossly visible lymphocystis nodules, as well as transformation and hypertrophy in cells of the connective tissues of various internal organs. (wikipedia.org)
  • Non-lipogenic sarcoma appears variable, can be high-grade (e.g. pleomorphic sarcoma, myxofibrosarcoma) or low grade (e.g. fibroblastic) spindle cells. (auanet.org)
  • a) Low-power view shows spindle cells arranged in tightly packed fascicles, with alternating hypo- and hypercellular areas and geographic necrosis (H&E stain, ×40). (hindawi.com)
  • Nuclei pucker in the natural aging process and in certain diseases including progeria , a rare and fatal genetic disorder that dramatically speeds up aging. (fredhutch.org)
  • Genetic manipulation of these cells in a lab setting supported that view as well. (phys.org)
  • In 1944 Oswald Avery, Colin MacLeod, and Maclyn McCarty partially purified cell extracts and presented evidence that the genetic component of these cells was DNA. (encyclopedia.com)
  • In 1952 Alfred Hershey and Martha Chase investigated the infection of Escherichia coli cells with phage T2 (a virus) and their results were further corroboration that DNA was the genetic material. (encyclopedia.com)
  • In addition to its mechanical support, the lamina helps regulate cell division and organize genetic material. (northwestern.edu)
  • Part of a cell that contains genetic information. (cancer.gov)
  • most of the genetic information and regulatory machinery responsible for providing the cell with its unique characteristics. (scribd.com)
  • Yeast genetic studies have identified cdc2 as an essential gene for cell division in yeast. (scribd.com)
  • The nucleus contains all the genetic material of the cell (as DNA in the chromosomes) and directs the activities of the cell by regulating the gene expression. (enotes.com)
  • The nucleus of a cell is where genetic material is stored (DNA, which stands for deoxyribose nucleic acid). (enotes.com)
  • The genetic code contained in our chromosomes is of no real use unless it can be used to make new cells. (s-cool.co.uk)
  • Molecular genetic methods are used to study abnormalities in chromosomes (the part of a cell that contains genetic information) or the DNA of cells. (cancer.ca)
  • In the 1930s-1950s Joachim Hämmerling conducted experiments in which he demonstrated Acetabularia's genetic information is contained in the nucleus. (wikipedia.org)
  • Carcinogenesis is caused by mutation and epimutation of the genetic material of normal cells, which upsets the normal balance between proliferation and cell death. (wikipedia.org)
  • HAP1 cells are a cell line used for biomedical and genetic research. (wikipedia.org)
  • Due to their haploidy, HAP1 cells are very useful in biomedical research and genetic experiments. (wikipedia.org)
  • The diagnosis is made either by testing of the fumarate hydratase activity in cultured skin fibroblasts or lymphoblastoid cells and demonstrating reduced activity (≤60%) or by molecular genetic testing. (wikipedia.org)
  • Sperm , also called spermatozoon, plural spermatozoa , male reproductive cell , produced by most animals. (britannica.com)
  • The sperm cells have only 23 chromosomes, or half of the usual number. (britannica.com)
  • When a sperm cell unites with the ovum, which also has 23 chromosomes, the resulting 46 chromosomes determine the offspring's characteristics. (britannica.com)
  • The sperm cells also carry the X or Y chromosome that determines the sex of the future child. (britannica.com)
  • sperm A sperm cell attempting to penetrate an egg (ovum) to fertilize it. (britannica.com)
  • The tail gives the sperm cell movement. (britannica.com)
  • Sperm cells may live in the human body for two or three days after mating. (britannica.com)
  • Between 1877 and 1878, Oscar Hertwig published several studies on the fertilization of sea urchin eggs, showing that the nucleus of the sperm enters the oocyte and fuses with its nucleus. (wikipedia.org)
  • Therefore, the necessity of the sperm nucleus for fertilization was discussed for quite some time. (wikipedia.org)
  • Most retroviruses infect somatic cells, but occasional infection of germline cells (cells that produce eggs and sperm) can also occur. (wikipedia.org)
  • Important exceptions include the gametes - sperm and egg cells - which are produced by meiosis. (wikipedia.org)
  • Water currents generated by the flagellum also push free-swimming cells along, as in animal sperm. (wikipedia.org)
  • Examples of protamines from fish are: salmine from salmon clupeine from herring sperm (Clupea) iridine from rainbow trout thinnine from tunafish (Thunnus) stelline from starry sturgeon (Acipenser stellatus) scylliorhinine from dogfish (Scylliorhinus) The primary structure of protamine P1, the protamine used for packaging DNA in sperm cells, in placental mammals is usually 49 or 50 amino acids long. (wikipedia.org)
  • Indeed, while in some ways homologous to cerebellar molecular layer stellate cells, SSCs exhibit properties that place them in a computationally unique position in the entire cochlear nucleus. (frontiersin.org)
  • The cochlear nucleus is the first 'relay station' of the central auditory system and receives mainly ipsilateral afferent input. (wikipedia.org)
  • Ear anatomy Cochlear nucleus innervated by a branching auditory nerve fibre Terminal nuclei of the vestibular nerve, with their upper connections. (wikipedia.org)
  • Host cell nuclei may be displaced, but are not distorted, except slightly by pressure from the parasite. (wikipedia.org)
  • Each cell gives rise to short central dendrites and a single long apical dendrite that expands into the granule cell layer and enters the mitral cell body layer. (wikipedia.org)
  • Excitatory inputs contacting apical dendrites of FCs come from granule cell parallel fibers located in the superficial molecular layer. (frontiersin.org)
  • The molecular layer domain comprises the parallel fiber input from granule cells, terminating on fusiform cell apical dendrites and onto cartwheel and SSC cells, both of which in turn control fusiform activity. (frontiersin.org)
  • Giant cells that are considerably larger than their neighbors may be formed and possess either one enormous nucleus or several nuclei (syncytia). (wikipedia.org)
  • In these cases, the morphotypes shared the same type of biliprotein but differed in periplast type, cell shape, flagellar apparatus ultrastructure and sometimes in cell size. (tolweb.org)
  • Background - Sensitivity to apoptotic signals, the clearance rate of apoptosis, and the apoptotic ultrastructure have not been studied in cells of the in vivo adult heart. (ahajournals.org)
  • Cells can have a very wide range of f_________ in the human body from skin cells, blood cells, muscle cells to nerve cells. (issuu.com)
  • Depression of this feedforward inhibitory input causes a shift in the balance of fusiform cell synaptic input towards greater excitation and suggests that fusiform cell spike output will be enhanced by physiological patterns of auditory nerve activity. (frontiersin.org)
  • Located in the subarachnoid space, blood vessels penetrate deeply into folds of the cerebellum to nourish and remove metabolic waste products from the nerve cells and neuroglia. (anatomyatlases.org)
  • Using this technique nerve cells with their highly branched dendrites and axon could be clearly visualised against a yellow background. (wikipedia.org)
  • It was reasonable at the time because under light microscope the nerve cells are merely a mesh of single thread. (wikipedia.org)
  • In the first issue of the Revista Trimestral de Histología Normal y Patológica (May, 1888) Cajal reported that the nerve cells were not continuous in the brain of birds. (wikipedia.org)
  • Cajal's discovery was the decisive evidence for the discontinuity of nervous system and the presence of large number of individual nerve cells. (wikipedia.org)
  • Cell division Nerve cells are generated by cell division. (wikipedia.org)
  • The nerve ring (excretory pore) and the nucleus of the excretory cell are said to be similar to B. malayi. (wikipedia.org)
  • Serious study of calico cats seems to have begun about 1948 when Murray Barr and his graduate student E.G. Bertram noticed dark, drumstick-shaped masses inside the nuclei of nerve cells of female cats, but not in male cats. (wikipedia.org)