Cell Movement
Movement
The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.
Gastrulation
Gastrula
The developmental stage that follows BLASTULA or BLASTOCYST. It is characterized by the morphogenetic cell movements including invagination, ingression, and involution. Gastrulation begins with the formation of the PRIMITIVE STREAK, and ends with the formation of three GERM LAYERS, the body plan of the mature organism.
Morphogenesis
Zebrafish
Dictyostelium
Chemotaxis
Zebrafish Proteins
Pseudopodia
Head Movements
Cell Polarity
Primitive Streak
Embryo, Nonmammalian
Movement Disorders
Body Patterning
The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.
Actins
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
Time-Lapse Imaging
Models, Biological
Microscopy, Video
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Plant Viral Movement Proteins
Cytoskeleton
Cell Surface Extensions
Gene Expression Regulation, Developmental
Fetal Movement
Mesoderm
Psychomotor Performance
Video Recording
Cell Aggregation
Motion Pictures as Topic
Wnt Proteins
Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.
Xenopus Proteins
Chick Embryo
Microfilament Proteins
Saccades
Myxococcus xanthus
Somites
Electromyography
Biomechanical Phenomena
Cadherins
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
rac GTP-Binding Proteins
Mutation
Notochord
A cartilaginous rod of mesodermal cells at the dorsal midline of all CHORDATE embryos. In lower vertebrates, notochord is the backbone of support. In the higher vertebrates, notochord is a transient structure, and segments of the vertebral column will develop around it. Notochord is also a source of midline signals that pattern surrounding tissues including the NEURAL TUBE development.
Cell Communication
In Situ Hybridization
Hand
rhoA GTP-Binding Protein
Green Fluorescent Proteins
Adherens Junctions
Anchoring points where the CYTOSKELETON of neighboring cells are connected to each other. They are composed of specialized areas of the plasma membrane where bundles of the ACTIN CYTOSKELETON attach to the membrane through the transmembrane linkers, CADHERINS, which in turn attach through their extracellular domains to cadherins in the neighboring cell membranes. In sheets of cells, they form into adhesion belts (zonula adherens) that go all the way around a cell.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Fixation, Ocular
Xenopus laevis
Cells, Cultured
Microscopy, Fluorescence
Wiskott-Aldrich Syndrome Protein Family
A family of microfilament proteins whose name derives from the fact that mutations in members of this protein family have been associated with WISKOTT-ALDRICH SYNDROME. They are involved in ACTIN polymerization and contain a polyproline-rich region that binds to PROFILIN, and a verprolin homology domain that binds G-ACTIN.
Actin Cytoskeleton
Microtubules
Oligoribonucleotides, Antisense
Cell Membrane
Microscopy, Phase-Contrast
Motor Cortex
Area of the FRONTAL LOBE concerned with primary motor control located in the dorsal PRECENTRAL GYRUS immediately anterior to the central sulcus. It is comprised of three areas: the primary motor cortex located on the anterior paracentral lobule on the medial surface of the brain; the premotor cortex located anterior to the primary motor cortex; and the supplementary motor area located on the midline surface of the hemisphere anterior to the primary motor cortex.
Xenopus
rho GTP-Binding Proteins
Pursuit, Smooth
Neural Crest
The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE.
Focal Adhesions
An anchoring junction of the cell to a non-cellular substrate. It is composed of a specialized area of the plasma membrane where bundles of the ACTIN CYTOSKELETON terminate and attach to the transmembrane linkers, INTEGRINS, which in turn attach through their extracellular domains to EXTRACELLULAR MATRIX PROTEINS.
Animals, Genetically Modified
Luminescent Proteins
Receptors, Eph Family
A large family of receptor protein-tyrosine kinases that are structurally-related. The name of this family of proteins derives from original protein Eph (now called the EPHA1 RECEPTOR), which was named after the cell line it was first discovered in: Erythropoietin-Producing human Hepatocellular carcinoma cell line. Members of this family have been implicated in regulation of cell-cell interactions involved in nervous system patterning and development.
NIH 3T3 Cells
A continuous cell line of high contact-inhibition established from NIH Swiss mouse embryo cultures. The cells are useful for DNA transfection and transformation studies. (From ATCC [Internet]. Virginia: American Type Culture Collection; c2002 [cited 2002 Sept 26]. Available from http://www.atcc.org/)
Chemotactic Factors
Blastoderm
Drosophila
Drosophila Proteins
Metencephalon
Microscopy, Confocal
Organizers, Embryonic
Cells in certain regions of an embryo that self-regulate embryonic development. These organizers have been found in dorsal and ventral poles of GASTRULA embryos, including Spemann organizer in amphibians, and Hensen node in chicken and mouse. These organizer cells communicate with each other via a network of secreted signaling proteins, such as BONE MORPHOGENETIC PROTEINS and their antagonists (chordin and noggin).
Microscopy, Interference
The science and application of a double-beam transmission interference microscope in which the illuminating light beam is split into two paths. One beam passes through the specimen while the other beam reflects off a reference mirror before joining and interfering with the other. The observed optical path difference between the two beams can be measured and used to discriminate minute differences in thickness and refraction of non-stained transparent specimens, such as living cells in culture.
Amino Acid Sequence
Myosin Type II
Photic Stimulation
Periodicity
Embryonic Induction
Membrane Proteins
Cell Lineage
Neurons
Extracellular Matrix
Blastula
Cytoskeletal Proteins
Embryo, Mammalian
Rotation
Fibroblasts
cdc42 GTP-Binding Protein
Cell Adhesion Molecules
Gene Knockdown Techniques
Fibroblast Growth Factors
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
Guanine Nucleotide Exchange Factors
Phenotype
Myxococcales
Adaptor Proteins, Signal Transducing
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
Computer Simulation
Microscopy, Electron, Scanning
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Seminiferous Epithelium
The epithelium lining the seminiferous tubules composed of primary male germ cells (SPERMATOGONIA) and supporting SERTOLI CELLS. As SPERMATOGENESIS proceeds, the developing germ cells migrate toward the lumen. The adluminal compartment, the inner two thirds of the tubules, contains SPERMATOCYTES and the more advanced germ cells.
Proprioception
Sensory functions that transduce stimuli received by proprioceptive receptors in joints, tendons, muscles, and the INNER EAR into neural impulses to be transmitted to the CENTRAL NERVOUS SYSTEM. Proprioception provides sense of stationary positions and movements of one's body parts, and is important in maintaining KINESTHESIA and POSTURAL BALANCE.
Intercellular Junctions
Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)
Rhombencephalon
The posterior of the three primitive cerebral vesicles of an embryonic brain. It consists of myelencephalon, metencephalon, and isthmus rhombencephali from which develop the major BRAIN STEM components, such as MEDULLA OBLONGATA from the myelencephalon, CEREBELLUM and PONS from the metencephalon, with the expanded cavity forming the FOURTH VENTRICLE.
Myosins
A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.
Ephrins
Signaling proteins that are ligands for the EPH FAMILY RECEPTORS. They are membrane-bound proteins that are attached to the CELL MEMBRANE either through a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR or through a transmembrane domain. Many of the ephrins are considered important intercellular signaling molecules that control morphogenic changes during embryogenesis.
Organogenesis
Macaca mulatta
Functional Laterality
Receptor, EphA4
Antigens, CD29
Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)
Cell Division
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Actomyosin
Fibronectins
Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.
Epithelium
Cell Tracking
Electrooculography
Recording of the average amplitude of the resting potential arising between the cornea and the retina in light and dark adaptation as the eyes turn a standard distance to the right and the left. The increase in potential with light adaptation is used to evaluate the condition of the retinal pigment epithelium.
Protein Transport
Recombinant Fusion Proteins
Chemotaxis, Leukocyte
Sleep, REM
Actin-Related Protein 2-3 Complex
Feedback, Sensory
rac1 GTP-Binding Protein
A rac GTP-binding protein involved in regulating actin filaments at the plasma membrane. It controls the development of filopodia and lamellipodia in cells and thereby influences cellular motility and adhesion. It is also involved in activation of NADPH OXIDASE. This enzyme was formerly listed as EC 3.6.1.47.
Integrins
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Blood-Testis Barrier
A specialized barrier, in the TESTIS, between the interstitial BLOOD compartment and the adluminal compartment of the SEMINIFEROUS TUBULES. The barrier is formed by layers of cells from the VASCULAR ENDOTHELIUM of the capillary BLOOD VESSELS, to the SEMINIFEROUS EPITHELIUM of the seminiferous tubules. TIGHT JUNCTIONS form between adjacent SERTOLI CELLS, as well as between the ENDOTHELIAL CELLS.
Carrier Proteins
Protein Binding
rho-Associated Kinases
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
Image Processing, Computer-Assisted
Blastomeres
Undifferentiated cells resulting from cleavage of a fertilized egg (ZYGOTE). Inside the intact ZONA PELLUCIDA, each cleavage yields two blastomeres of about half size of the parent cell. Up to the 8-cell stage, all of the blastomeres are totipotent. The 16-cell MORULA contains outer cells and inner cells.
Cytoplasm
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Kinesthesis
Cortactin
Locomotion
Cell Differentiation
Focal Adhesion Protein-Tyrosine Kinases
Proto-Oncogene Proteins c-fyn
Microinjections
Vertebrates
Germ Layers
Cyclic AMP
LIM Domain Proteins
A large class of structurally-related proteins that contain one or more LIM zinc finger domains. Many of the proteins in this class are involved in intracellular signaling processes and mediate their effects via LIM domain protein-protein interactions. The name LIM is derived from the first three proteins in which the motif was found: LIN-11, Isl1 and Mec-3.
Nervous System
Actin Depolymerizing Factors
Reflex, Vestibulo-Ocular
A reflex wherein impulses are conveyed from the cupulas of the SEMICIRCULAR CANALS and from the OTOLITHIC MEMBRANE of the SACCULE AND UTRICLE via the VESTIBULAR NUCLEI of the BRAIN STEM and the median longitudinal fasciculus to the OCULOMOTOR NERVE nuclei. It functions to maintain a stable retinal image during head rotation by generating appropriate compensatory EYE MOVEMENTS.
Transcription Factors
Caenorhabditis elegans
Visual Perception
Phosphorylation
Homeodomain Proteins
Dyskinesias
Abnormal involuntary movements which primarily affect the extremities, trunk, or jaw that occur as a manifestation of an underlying disease process. Conditions which feature recurrent or persistent episodes of dyskinesia as a primary manifestation of disease may be referred to as dyskinesia syndromes (see MOVEMENT DISORDERS). Dyskinesias are also a relatively common manifestation of BASAL GANGLIA DISEASES.
Muscle, Skeletal
Immunohistochemistry
Base Sequence
Microscopy, Electron
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Monomeric GTP-Binding Proteins
A class of monomeric, low molecular weight (20-25 kDa) GTP-binding proteins that regulate a variety of intracellular processes. The GTP bound form of the protein is active and limited by its inherent GTPase activity, which is controlled by an array of GTPase activators, GDP dissociation inhibitors, and guanine nucleotide exchange factors. This enzyme was formerly listed as EC 3.6.1.47
Motion
Intracellular Signaling Peptides and Proteins
Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.
Laminin
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Head
Glycoproteins
Immunoprecipitation
Nonbehavioral selection for pawns, mutants of Paramecium aurelia with decreased excitability. (1/32044)
The reversal response in Paramecium aurelia is mediated by calcium which carries the inward current during excitation. Electrophysiological studies indicate that strontium and barium can also carry the inward current. Exposure to high concentrations of barium rapidly paralyzes and later kills wild-type paramecia. Following mutagenesis with nitrosoguanidine, seven mutants which continued to swim in the ;high-barium' solution were selected. All of the mutants show decreased reversal behavior, with phenotypes ranging from extremely non-reversing (;extreme' pawns) to nearly wild-type reversal behavior (;partial' pawns). The mutations fall into three complementation groups, identical to the pwA, pwB, and pwC genes of Kunget al. (1975). All of the pwA and pwB mutants withstand longer exposure to barium, the pwB mutants surviving longer than the pwA mutants. Among mutants of each gene, survival is correlated with loss of reversal behavior. Double mutants (A-B, A-C, B-C), identified in the exautogamous progeny of crosses between ;partial' mutants, exhibited a more extreme non-reversing phenotype than either of their single-mutant (;partial' pawn) parents.---Inability to reverse could be expected from an alteration in the calcium-activated reversal mechanism or in excitation. A normal calcium-activated structure was demonstrated in all pawns by chlorpromazine treatment. In a separate report (Schein, Bennett and Katz 1976) the results of electrophysiological investigations directly demonstrate decreased excitability in all of the mutants, a decrease due to an altered calcium activation. The studies of the genetics, the survival in barium and the electro-physiology of the pawns demonstrate that the pwA and pwB genes have different effects on calcium activation. (+info)Polarized distribution of Bcr-Abl in migrating myeloid cells and co-localization of Bcr-Abl and its target proteins. (2/32044)
Bcr-Abl plays a critical role in the pathogenesis of Philadelphia chromosome-positive leukemia. Although a large number of substrates and interacting proteins of Bcr-Abl have been identified, it remains unclear whether Bcr-Abl assembles multi-protein complexes and if it does where these complexes are within cells. We have investigated the localization of Bcr-Abl in 32D myeloid cells attached to the extracellular matrix. We have found that Bcr-Abl displays a polarized distribution, colocalizing with a subset of filamentous actin at trailing portions of migrating 32D cells, and localizes on the cortical F-actin and on vesicle-like structures in resting 32D cells. Deletion of the actin binding domain of Bcr-Abl (Bcr-AbI-AD) dramatically enhances the localization of Bcr-Abl on the vesicle-like structures. These distinct localization patterns of Bcr-Abl and Bcr-Abl-AD enabled us to examine the localization of Bcr-Abl substrate and interacting proteins in relation to Bcr-Abl. We found that a subset of biochemically defined target proteins of Bcr-Abl redistributed and co-localized with Bcr-Abl on F-actin and on vesicle-like structures. The co-localization of signaling proteins with Bcr-Abl at its sites of localization supports the idea that Bcr-Abl forms a multi-protein signaling complex, while the polarized distribution and vesicle-like localization of Bcr-Abl may play a role in leukemogenesis. (+info)The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. (3/32044)
PINCH is a widely expressed and evolutionarily conserved protein comprising primarily five LIM domains, which are cysteine-rich consensus sequences implicated in mediating protein-protein interactions. We report here that PINCH is a binding protein for integrin-linked kinase (ILK), an intracellular serine/threonine protein kinase that plays important roles in the cell adhesion, growth factor, and Wnt signaling pathways. The interaction between ILK and PINCH has been consistently observed under a variety of experimental conditions. They have interacted in yeast two-hybrid assays, in solution, and in solid-phase-based binding assays. Furthermore, ILK, but not vinculin or focal adhesion kinase, has been coisolated with PINCH from mammalian cells by immunoaffinity chromatography, indicating that PINCH and ILK associate with each other in vivo. The PINCH-ILK interaction is mediated by the N-terminal-most LIM domain (LIM1, residues 1 to 70) of PINCH and multiple ankyrin (ANK) repeats located within the N-terminal domain (residues 1 to 163) of ILK. Additionally, biochemical studies indicate that ILK, through the interaction with PINCH, is capable of forming a ternary complex with Nck-2, an SH2/SH3-containing adapter protein implicated in growth factor receptor kinase and small GTPase signaling pathways. Finally, we have found that PINCH is concentrated in peripheral ruffles of cells spreading on fibronectin and have detected clusters of PINCH that are colocalized with the alpha5beta1 integrins. These results demonstrate a specific protein recognition mechanism utilizing a specific LIM domain and multiple ANK repeats and suggest that PINCH functions as an adapter protein connecting ILK and the integrins with components of growth factor receptor kinase and small GTPase signaling pathways. (+info)Transduction of glioma cells using a high-titer retroviral vector system and their subsequent migration in brain tumors. (4/32044)
The intracranial migration of transduced glioma cells was investigated in order to improve the treatment of malignant glioma by gene therapy using retroviral vectors. In this study, about half the volume of the tumor mass could be transduced in 14 days after only a single implantation of 3 x 10(5) retrovirus-producing cells into a tumor mass with a diameter of 5 mm. Moreover, we were able to follow the migration of glioma cells transduced by the lacZ-harboring retroviruses originating from the high-titer retrovirus-producing cells. Besides the importance of using a high-titer retroviral vector system, our results also indicate that the implantation site of the virus-producing cells and the interval between the implantation of the virus-producing cells and the subsequent administration of ganciclovir are important factors for the efficient killing of glioma cells. (+info)Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness. (5/32044)
ICAM-2-deficient mice exhibit prolonged accumulation of eosinophils in lung interstitium concomitant with a delayed increase in eosinophil numbers in the airway lumen during the development of allergic lung inflammation. The ICAM-2-dependent increased and prolonged accumulation of eosinophils in lung interstitium results in prolonged, heightened airway hyperresponsiveness. These findings reveal an essential role for ICAM-2 in the development of the inflammatory and respiratory components of allergic lung disease. This phenotype is caused by the lack of ICAM-2 expression on non-hematopoietic cells. ICAM-2 deficiency on endothelial cells causes reduced eosinophil transmigration in vitro. ICAM-2 is not essential for lymphocyte homing or the development of leukocytes, with the exception of megakaryocyte progenitors, which are significantly reduced. (+info)Anti-monocyte chemoattractant protein-1/monocyte chemotactic and activating factor antibody inhibits neointimal hyperplasia in injured rat carotid arteries. (6/32044)
Monocyte chemoattractant protein-1 (MCP-1)/monocyte chemotactic and activating factor (MCAF) has been suggested to promote atherogenesis. The effects of in vivo neutralization of MCP-1 in a rat model were examined in an effort to clarify the role of MCP-1 in the development of neointimal hyperplasia. Competitive polymerase chain reaction analysis revealed maximum MCP-1 mRNA expression at 4 hours after carotid arterial injury. Increased immunoreactivities of MCP-1 were also detected at 2 and 8 hours after injury. Either anti-MCP-1 antibody or nonimmunized goat IgG (10 mg/kg) was then administered every 12 hours to rats that had undergone carotid arterial injury. Treatment with 3 consecutive doses of anti-MCP-1 antibody within 24 hours (experiment 1) and every 12 hours for 5 days (experiment 2) significantly inhibited neointimal hyperplasia at day 14, resulting in a 27.8% reduction of the mean intima/media ratio (P<0.05) in experiment 1 and a 43.6% reduction (P<0.01) in experiment 2. This effect was still apparent at day 56 (55.6% inhibition; P<0.05). The number of vascular smooth muscle cells in the neointima at day 4 was significantly reduced by anti-MCP-1 treatment, demonstrating the important role of MCP-1 in early neointimal lesion formation. However, recombinant MCP-1 did not stimulate chemotaxis of vascular smooth muscle cells in an in vitro migration assay. These results suggest that MCP-1 promotes neointimal hyperplasia in early neointimal lesion formation and that neutralization of MCP-1 before, and immediately after, arterial injury may be effective in preventing restenosis after angioplasty. Further studies are needed to clarify the mechanism underlying the promotion of neointimal hyperplasia by MCP-1. (+info)Non-serum-dependent chemotactic factors produced by Candida albicans stimulate chemotaxis by binding to the formyl peptide receptor on neutrophils and to an unknown receptor on macrophages. (7/32044)
Serum-free culture filtrates of six Candida species and Saccharomyces cerevisiae were found to contain chemoattractants for human polymorphonuclear leukocytes (PMNs) and a mouse macrophage-like cell line, J774. The chemotactic factors differed for the PMN and J774 cells, however, in terms of heat stability, kinetics of liberation by the yeast cells, and divalent cation requirements for production. The chemoattractant in Candida albicans culture filtrates appeared to act through the formyl peptide receptor (FPR) of PMNs, since it was found to induce chemotaxis of Chinese hamster ovary (CHO) cells that were expressing the human FPR but did not induce chemotaxis of wild-type CHO cells. The C. albicans culture filtrates also induced migration of PMNs across confluent monolayers of a human gastrointestinal epithelial cell line, T84; migration occurred in the basolateral-to-apical direction but not the reverse direction, unless the epithelial tight junctions were disrupted. J774 cells did not migrate toward the formylated peptide (fMet-Leu-Phe; fMLF), and chemotaxis toward the C. albicans culture filtrate was not inhibited by an FPR antagonist (t-butoxycarbonyl-Met-Leu-Phe), suggesting that a different receptor mediated J774 cell chemotaxis. In conclusion, we have identified a receptor by which a non-serum-dependent chemotactic factor (NSCF) produced by C. albicans induced chemotaxis of PMNs. Additionally, we have shown that NSCF was active across epithelial monolayers. These findings suggest that NSCFs produced by C. albicans and other yeast species may influence host-pathogen interactions at the gastrointestinal tract mucosal surface by inducing phagocytic-cell infiltration. (+info)Role of the extracellular signal-regulated protein kinase cascade in human neutrophil killing of Staphylococcus aureus and Candida albicans and in migration. (8/32044)
Killing of Staphylococcus aureus and Candida albicans by neutrophils involves adherence of the microorganisms, phagocytosis, and a collaborative action of oxygen reactive species and components of the granules. While a number of intracellular signalling pathways have been proposed to regulate neutrophil responses, the extent to which each pathway contributes to the killing of S. aureus and C. albicans has not been clearly defined. We have therefore examined the effect of blocking one such pathway, the extracellular signal-regulated protein kinase (ERK) cascade, using the specific inhibitor of the mitogen-activated protein kinase/ERK kinase, PD98059, on the ability of human neutrophils to kill S. aureus and C. albicans. Our data demonstrate the presence of ERK2 and a 43-kDa form of ERK but not ERK1 in human neutrophils. Upon stimulation with formyl methionyl leucyl phenylalanine (fMLP), the activities of both ERK2 and the 43-kDa form were stimulated. Despite abrogating the activity of both ERK forms, PD98059 only slightly reduced the ability of neutrophils to kill S. aureus or C. albicans. This is consistent with our finding that PD98059 had no effect on neutrophil adherence or degranulation, although pretreatment of neutrophils with PD98059 inhibited fMLP-stimulated superoxide production by 50%, suggesting that a change in superoxide production per se is not strictly correlated with microbicidal activity. However, fMLP-stimulated chemokinesis was markedly inhibited, while random migration and fMLP-stimulated chemotaxis were partially inhibited, by PD98059. These data demonstrate, for the first time, that the ERK cascade plays only a minor role in the microbicidal activity of neutrophils and that the ERK cascade is involved primarily in regulating neutrophil migration in response to fMLP. (+info)The Nationalism Project: Articles in Journal of Ethnic and Migration Studies
KOPS.Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity
Analysis of Random Migration of Cancer Cells in 3D
The First Familys chain migration
Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet...
FRNK blocks v‐Src‐stimulated invasion and experimental metastases without effects on cell motility or growth | The EMBO Journal
Neural precursor cell chain migration and division are regulated through different beta1 integrins | Development
Key role of PI3Kγ in monocyte chemotactic protein-1-mediated amplification of PDGF-induced aortic smooth muscle cell migration....
An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration | BMC...
Mechanical guidance of collective cell migration and invasion
Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet...
Plus it
British Library EThOS: An investigation into the role of protein kinases in T lymphocyte migration
Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux
Hydrogen Peroxide Triggers a Dual Signaling Axis To Selectively Suppress Activated Human T Lymphocyte Migration.<...
A microcarrier-based spheroid 3D invasion assay to monitor dynamic cell movement in extracellular matrix | Biological...
Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi - UEA Digital...
Substrate area confinement is a key determinant of cell velocity in collective migration | Nature Physics
Metalloproteinase-Dependent and -Independent processes contribute to inhibition of breast cancer cell migration, angiogenesis...
Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis...
Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis...
Internal forces directing cell migration are revealed by live-cell microscopy
Cell Migration, Invasion and Wound Healing | Cell Biolabs
DataSpace: Signals specifying polarity, adhesion, developmental timing, and cell identity are important for border cell...
Arl13b regulates breast cancer cell migration and invasion by controlling integrin-mediated signaling<...
Plus it
There are numerous biological examples where genes associated with migratory ability | Beneficial Effects of RAF Inhibitor i
Regulatory T Cell Transmigration and Intravascular Migration Undergo Mechanistically Distinct Regulation at Different Phases of...
Integrin αMβ2-Mediated Cell Migration to Fibrinogen and Its Recognition Peptides | JEM
Short courses (certificate) - Introduction to Migration Studies - 1 month - Maastricht University
This page is protected. You can view its source [e]
Ratchetaxis: Long-Range Directed Cell Migration by Local Cues
BMP4 inhibits the proliferation of breast cancer cells and induces an MMP-dependent migratory phenotype in MDA-MB-231 cells in...
Effect of TGFβ1 on the phenotype, migratory ability, a | Open-i
The Basic Principles Of Breast Enhancement
Group choreography: Mechanisms orchestrating the collective movement of border cells<...
RePub, Erasmus University Repository:
A microcarrier-based spheroid 3D invasion assay to monitor dynamic cell movement in...
Natalie Reid | COX-2 contributes to the maintenance of flow-induced dilation | Page 2
Vol 10: Propagating Waves of Directionality and Coordination Orchestrate Collective Cell Migration. - pdf descargar
Epigenetic down-regulation of integrin α7 increases migratory potential and confers poor prognosis in malignant pleural...
Examples of collective cell migration. First column: sc | Open-i
Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivotumor growth |...
Search Results | UCP
Comparative analysis of the role of small G proteins in cell migration and cell death: Cytoprotective and promigratory effects...
mTOR Signaling in Cancer Cell Motility and Tumor Metastasis - Critical Reviews™ in Eukaryotic Gene Expression, Том 20, 2010,...
Protocols and Video Articles Authored by Gersende Alphonse
Theoretical model for persistent and oscillatory cell motility | Isaac Newton Institute for Mathematical Sciences
Involvement of cysteine-rich protein 61 in the epidermal growth factor-induced migration of human anaplastic thyroid cancer...
T Lymphocyte Migration Inhibitory Factors - How is T Lymphocyte Migration Inhibitory Factors abbreviated?
Combined Treatment with Troglitazone and Lovastatin Inhibited Epidermal Growth Factor-Induced Migration through the...
Ring cell migration assay identifies distinct effects of extracellular matrix proteins on cancer cell migration | BMC Research...
Rho GTPase: A molecular compass for directional cell migration<...
Salinomycin treatment reduces metastatic tumor burden by hampering cancer cell migration
The secreted semaphorin Sema3E controls cell migration and invasiveness in cancer - GLO1 inhibitors for neuropsychiatric
SNU Open Repository and Archive: Hypoxia inhibits the SDF-1-dependent migration of human leukemic cell line HL-60 via blocking...
Bursts of activity in collective cell migration | PNAS
DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion | JCB
Function of the ETS transcription factor Yan in border cell migration | Development
Inactivation of Cyclic Di-GMP Binding Protein TDE0214 Affects the Motility, Biofilm Formation, and Virulence of Treponema...
An optimized method for accurate quantification of cell migration using human small intestine cells - Forskning - Aarhus...
Medical Advisor Journals by Kyle J. Norton: Hormone Prostaglandins E2 in promotion of lung cancer cell migration
Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration. | IRIC - Institute...
Proper migration and axon outgrowth of zebrafish cranial motoneuron subpopulations require the cell adhesion molecule MDGA2A |...
Supplementary Materials Supplemental Materials supp 28 14 1924 index | Involvement of an Extracellular Protease in Algicidal...
Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility...
Glycidamide promotes the growth and migratory ability of prostate cancer cells by changing the protein expression of cell cycle...
L-Selectin Shedding Does Not Regulate Constitutive T Cell Trafficking but Controls the Migration Pathways of Antigen-activated...
Collective Cell Migration in Neural Crest Development
Mechanisms of human skin cell migration and wound healing :: University of Southern California Dissertations and Theses
E3 Ligase Activity of XIAP RING Domain Is Required for XIAP-Mediated Cancer Cell Migration, but Not for Its RhoGDI Binding...
NHE3 phosphorylation via PKCη marks the polarity and orientation of directionally migrating cells<...
Radius 24-Well Cell Migration Assay (Laminin Coated) - PDF
Plus it
VackvSuG: A POSSIBLE HEALTHY ACTIVITY CLOSING THE YAC GAPS
Durotaxis - Wikipedia
How migratory cells find their way through body tissue | Channels - McGill University
Plus it
Oris™ Cell Migration Assay | Platypus Technologies
PDF] microRNAs: tiny RNA molecules, huge driving forces to move the cell | Semantic Scholar
MMP28 (epilysin) as a novel promoter of invasion and metastasis in gastric cancer | BMC Cancer | Full Text
Motile chondrocytes from newborn calf: migration properties and synthesis of collagen II. - PubMed - NCBI
3D cell migration computational model | Interface Focus
Microtubule associated signal transduction processes in t-cell migration
3D time lapse imaging and quantitative analysis of the active migration of human vascular endothelial cells into a multilayered...
3D time lapse imaging and quantitative analysis of the active migration of human vascular endothelial cells into a multilayered...
Aging | - Figure
Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/mTOR pathways on cell migration in MDA-MB-231 cells : Sussex...
SCAI (N-terminal region) Antibody - ECM Biosciences
The Subcellular Localisation of HAX1 Isoforms and Their Roles in Cancer Cell Migration, Autophagy and Apoptosis.
Guard cell
The turgor pressure of guard cells is controlled by movements of large quantities of ions and sugars into and out of the guard ... Each guard cell has a relatively thick cuticle on the pore-side and a thin one opposite it. As water enters the cell, the thin ... Guard cells are specialized plant cells in the epidermis of leaves, stems and other organs that are used to control gas ... Guard cells also provide an excellent model for basic studies on how a cell integrates numerous kinds of input signals to ...
Cell (biology)
Cell shape, also called cell morphology, has been hypothesized to form from the arrangement and movement of the cytoskeleton. ... In mammals, major cell types include skin cells, muscle cells, neurons, blood cells, fibroblasts, stem cells, and others. Cell ... Some eukaryotic cells (plant cells and fungal cells) also have a cell wall. Inside the cell is the cytoplasmic region that ... Cell nucleus: A cell's information center, the cell nucleus is the most conspicuous organelle found in a eukaryotic cell. It ...
Genome editing
Modified donor T cells were engineered to attack the leukemia cells, to be resistant to Alemtuzumab, and to evade detection by ... Im W, Moon J, Kim M (September 2016). "Applications of CRISPR/Cas9 for Gene Editing in Hereditary Movement Disorders". Journal ... For example, when one is planning to use the cell's NHEJ to create a mutation, the cell's HDR systems will also be at work ... yeast or mammal cells have been developed to identify the combinations that offer the best specificity and the best cell ...
Pridopidine
Huntington Study Group". Movement Disorders. 11 (2): 136-142. March 1996. doi:10.1002/mds.870110204. ISSN 0885-3185. PMID ... The Huntington's Disease Collaborative Research Group". Cell. 72 (6): 971-983. 1993-03-26. doi:10.1016/0092-8674(93)90585-e. ... induced cell death in mouse primary HD neurons and human HD iPSCs. It restores the impaired synaptic plasticity in HD neurons, ... Cell Death & Disease. 10 (3): 210. doi:10.1038/s41419-019-1451-2. ISSN 2041-4889. PMC 6397200. PMID 30824685. Geva, Michal; ...
Gliding motility
Shrivastava, Abhishek (2016). "The Screw-Like Movement of a Gliding Bacterium Is Powered by Spiral Motion of Cell-Surface ... McBride, Mark J. (2001-10-01). "Bacterial gliding motility: Multiple mechanisms for cell movement over surfaces". Annual Review ... McBride, M. (2001). "Bacterial gliding motility: Multiple mechanisms for cell movement over surfaces". Annual Review of ... "Acetate acts as a protonophore and differentially affects bead movement and cell migration of the gliding bacterium Cytophaga ...
Friedreich's ataxia
In FRDA, cells produce less frataxin. Degeneration of nerve tissue in the spinal cord causes the ataxia; particularly affected ... The sensory neurons essential for directing muscle movement of the arms and legs through connections with the cerebellum are ... The spinal cord becomes thinner and nerve cells lose some myelin sheath. The diameter of the spinal cord is smaller than that ... Nrf2 is decreased in FRDA cells. PTC-743 (formerly EPI-743) is being developed by PTC Therapeutics. PTC-743 is a para- ...
Flagellum
doi:10.1111/j.1095-8339.1976.tb01352.x. Sleigh MA (1985). "Origin and evolution of flagellar movement". Cell Motil. 5: 137-138 ... akrokont: cells with flagella inserted apically subakrokont: cells with flagella inserted subapically pleurokont: cells with ... The flagellum is encased within the cell's plasma membrane, so that the interior of the flagellum is accessible to the cell's ... Both flagella and archaella consist of filaments extending outside the cell, and rotate to propel the cell. Archaeal flagella ...
Angiopellosis
... (cell extravasation) is the movement of cells out of the circulatory system into the surrounding tissue. This ... Cells that are normally found in circulation (i.e. blood cells) either extravasate through diapedesis (white blood cells), or ... The endothelial cells extend protrusions and actively remodel themselves around the exiting cells The exiting cell will then be ... The endothelial cells recognize the cell through membrane-specific recognition. Recognition of cell is important and is thought ...
Open Source Drug Discovery
Seema Singh (April 2008). "India Takes an Open Source Approach to Drug Discovery". Cell. 133 (2): 201-203. doi:10.1016/j.cell. ... "Join the movement - Open Source Drug Discovery". Osdd.net. Retrieved 2015-04-30. ... WP5 - Micro array gene expression for human cells and tissues with the best inhibitors. This involves identification of ... compounds with higher binding affinity for the target without altering expression profile of host cell. WP6 - Medicinal ...
Antioch International Movement of Churches
Lifegroups follow a cell ministry model. The churches within the Antioch Movement recognize marriage as only between the ... The movement is primarily focused on church planting and is non-denominational. The movement became well-known after two of its ... Notable in the movement's history is the arrest and imprisonment of Heather Mercer and Dayna Curry by the Taliban on August 3, ... The movement's first discipleship school was held at Highland Baptist Church in Waco, Texas, led by Jimmy and Laura Seibert in ...
Juice (skateboarding magazine)
"Team/Movement «". Woundedkneeskateboards.net. 2009-10-23. Retrieved 2015-11-21. "Andy Kessler". Juice Magazine. Retrieved ... FEET] VENICE SKATEBOARD PARK". Cell-Less Productions. Retrieved 2015-11-21. "The Living Legacy: George Powell inspired by ... cell-lessproductions.com. Retrieved October 29, 2009. "Wounded Knee Skateboards". Wounded Knee Skateboards. Retrieved 2015-11- ...
Nyctinasty
Anatomically, the movements are mediated by pulvini. Pulvinus cells are located at the base or apex of the petiole and the flux ... The leaf movement factor of Chamaecrista mimosoides (formerly Cassia mimosoides) was found to not bind to the motor cell of ... Non-pulvinar mediated movement is also possible and happens through differential cell division and growth on either side of the ... The leaf movement factor of Albizia julibrissin similarly didn't bind to the motor cell of Chamaecrista mimosoides, but did ...
Plant nucleus movement
... is the movement of the cell nucleus in plants by the cytoskeleton. An important aspect of plant behavior ... The integration of the stimuli in plant cells is not fully understood, but the movement of the cell nucleus provides one ... In potato cells, oomycete contact results in rapid movement of the nucleus to the site of contact, which initiates rapid ... Nuclear movement also occurs in response to mechanical stimulation. The nuclei of cultured ovule parenchyma tobacco cells were ...
Shade tolerance
January-February 2009; 2(1): 50-55 Koller D (1990). "Light-driven leaf movements". Plant, Cell & Environment. 13 (7): 615-632. ... Developmental movements are slow and irreversible. Chloroplast movement is one of the plant adaptations to the changing light ... A study suggested that chloroplast movement shared the same photoreceptor with leaf movement as they showed similar action ... Active movements are reversible. Some plants use blue-light absorbing pigments as a sensor and pulvinar motor tissue to drive ...
ADAR
Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. ... Movement Disorders. 21 (9): 1510-1513. doi:10.1002/mds.21011. PMID 16817193. S2CID 38374943. Weiden MD, Hoshino S, Levy DN, Li ... ADAR is able to modify and regulate the output of gene product, as inosine is interpreted by the cell to be guanosine. ADAR can ... ADAR1 is an interferon ( IFN )-inducible protein (one released by a cell in response to a pathogen or virus), able to assist in ...
Neuromuscular junction
Cell Stem Cell. 18 (1): 134-43. doi:10.1016/j.stem.2015.10.002. PMC 4707991. PMID 26549107. Papapetropoulos S, Singer C (April ... MG can be transferred from the mother to the fetus by the movement of AChR antibodies through the placenta. Signs of this ... During development, muscle cells produce acetylcholine receptors (AChRs) and express them in the central regions in a process ... 50-60% of the patients that are diagnosed with LEMS also have present an associated tumor, which is typically small-cell lung ...
Secondary palate development
Mesenchyme cell contraction; Epithelial reorganisation; Movement of the developing tongue. Fusion between the two palatal ... The direct cause of this movement is unknown, but a number of possibilities have been identified as follows: Muscular ... Epithelial cell migration. Pharyngeal arch - Embryonic precursor structures in vertebrates Sadler, T.W (2004). Langman's ...
Thomas P. Stossel
The machinery of cell crawling. Sci Am. 1994; 271: 54-63. 69. Stossel, TP. The machinery of cell movements. The 1993 E. Donnall ... Dev Cell, 2003, 4: 444-445. 77. Stossel, TP, Fenteany G, Hartwig, JH. Cell surface actin remodeling at a glance. J Cell Sci, ... Role in cytoplasmic movement and phagocytosis. J Cell Biol. 1976; 68:602-619. 32. Boxer LA, Stossel TP. Interactions of actin, ... Actin gelation and the structure and movement of cortical cytoplasm. Cell Surface Reviews. In: Cytoskeletal Elements and Plasma ...
Trichamoeba
Bhowmick DK (March 1967). "Electron microscopy of Trichamoeba villosa and amoeboid movement". Exp. Cell Res. 45 (3): 570-89. ...
Cell migration
As cell movement is very slow, a few µm/minute, time-lapse microscopy videos are recorded of the migrating cells to speed up ... Cells achieve active movement by very different mechanisms. Many less complex prokaryotic organisms (and sperm cells) use ... These observations provide strong support for models of cell movement which depend on a rearward cell surface membrane flow ( ... Cell Migration Gateway The Cell Migration Gateway is a comprehensive and regularly updated resource on cell migration The ...
Learning
Liscum, Emmanuel (January 2014). "Phototropism: Growing towards an Understanding of Plant Movement". Plant Cell. 1 (1): 38-55. ... into the cell. This ion influx triggers a passive flow of water into the cell down its osmotic gradient, effectively increasing ... Mechanosensory proteins in cell lipid bilayers, known as MS ion channels, are activated once they are physically deformed in ... Previous experimentation shows that plants respond to light by bending and growing towards it through differential cell growth ...
Retinal ganglion cell
Photosensitive ganglion cells Other ganglion cells projecting to the superior colliculus for eye movements (saccades) P-type ... Midget cell (parvocellular, or P pathway; P cells) Parasol cell (magnocellular, or M pathway; M cells) Bistratified cell ( ... bipolar cells and retina amacrine cells. Retina amacrine cells, particularly narrow field cells, are important for creating ... These cells are known as midget retinal ganglion cells, based on the small sizes of their dendritic trees and cell bodies. ...
Cell-based therapies for Parkinson's disease
Jankovic, Joseph; Tolosa, Eduardo (2015). "49". Parkinson's Disease and Movement Disorders (6th ed.). Philadelphia: Wolters ... It includes two populations of cells; glomus (type I) cells and sustentacular (type II) cells. Glomus cells are derived from ... body retinal pigment epithelium embryonic stem cells induced pluripotent stem cells mesenchymal stem cells The first cell-based ... Thus, cell transplantation has focused on various dopamine producing cells throughout the body. fetal ventral mesencephalic ...
Intrinsically photosensitive retinal ganglion cell
Bistratified cell Melanopsin Midget cell Parasol cell Photoreceptor Keeler, Clyde E. (1927). "Iris movements in blind mice". ... DA cells) via reciprocal synapses, with ipRGCs sending excitatory signals to the DA cells, and the DA cells sending inhibitory ... Unlike the visual opsins in rod cells and cone cells, which rely on the standard visual cycles for recharging all-trans-retinal ... An ipRGC therefore does not rely on Müller cells and/or retinal pigment epithelium cells for this conversion. The two isoforms ...
Biomedical engineering
... cells and cell organelles, using the methods of mechanics. A biomaterial is any matter, surface, or construct that interacts ... ISBN 978-1-78262-847-7. Alexander R. McNeill (2005). "Mechanics of animal movement". Current Biology. 15 (16): R616-R619. doi: ... 2014). Cell Surface Engineering. Smart Materials Series. Cambridge: Royal Society of Chemistry. doi:10.1039/9781782628477. ... "Doctors grow organs from patients' own cells". CNN. April 3, 2006. Trial begins for first artificial liver device using human ...
Stop codon
Cell. 166 (3): 691-702. doi:10.1016/j.cell.2016.06.020. PMC 4967479. PMID 27426948. Zinoni, F; Birkmann, A; Stadtman, T; Böck, ... Loss Mutation Associated with Complex Early Onset Movement Disorder without Epilepsy". Movement Disorders Clinical Practice. 9 ... In 2010 when Craig Venter unveiled the first fully functioning, reproducing cell controlled by synthetic DNA he described how ... Molecular Cell. 13 (2): 157-68. doi:10.1016/S1097-2765(04)00031-0. PMID 14759362. Schueren F, Lingner T, George R, Hofhuis J, ...
PARL
Cell Death and Differentiation. 14 (7): 1275-84. doi:10.1038/sj.cdd.4402145. PMID 17464328. Heinitz S, Klein C, Djarmati A (Nov ... Movement Disorders. 26 (13): 2441-2. doi:10.1002/mds.23889. PMID 21953724. S2CID 45301679. Walder K, Kerr-Bayles L, Civitarese ... thus promoting retinal ganglion cell death and neurodegeneration. PARL has been shown to interact with: PINK1, OPA1, and HAX1. ...
Sanaullah Khan Zehri
... elections cell. Retrieved 10 October 2014. Malik Siraj Akbar (2011). The Redefined Dimensions of Baloch Nationalist Movement. ... His father, Sardar Doda Khan Zehri, was a tribal leader and an activist in the Pakistan Movement who played a crucial role in ... "GEO elections monitoring cell: Sanaullah Zehri". GEO News, ...
Rapid eye movement sleep
Deboer, T (2007). "Technologies of sleep research". Cell Mol Life Sci. 64 (10): 1227-1235. doi:10.1007/s00018-007-6533-0. PMC ... These eye movements follow the ponto-geniculo-occipital waves originating in the brain stem. The eye movements themselves may ... Most of the eye movements in "rapid eye movement" sleep are in fact less rapid than those normally exhibited by waking humans. ... Furthermore, eye movements play a role in certain psychotherapies such as Eye Movement Desensitization and Reprocessing (EMDR ...
Sperm
... the sperm cells are amoeboid and crawl, rather than swim, towards the egg cell. Non-motile sperm cells called spermatia lack ... "Flagellar movement of human spermatozoa". Gamete Research. 13 (3): 185-197. doi:10.1002/mrd.1120130302. Fishman, Emily L; Jo, ... Sperm cells are carried out of the male body in a fluid known as semen. Human sperm cells can survive within the female ... The sperm cells are the only flagellated cells in the life cycle of these plants. In many ferns and lycophytes, cycads and ...
Will Hall (writer)
Hearing Voices Movement Psychiatric survivors movement Biopsychiatry controversy Trauma model of mental disorders Social model ... He spent a year in the public mental health system, including restraints, solitary confinement in a padded cell, and more than ... he is involved in the recovery approach in mental health and is an organizer within the psychiatric survivors movement. Hall ...
Atrioventricular node
Contraction of heart muscle cells requires depolarization and repolarization of their cell membranes. Movement of ions across ... Bone morphogenetic protein (BMP) cell signaling plays a key role in diverse aspects of cardiac differentiation and ... cell membranes causes these events. The cardiac conduction system (and AV node part of it) coordinates myocyte mechanical ...
Janet Plowe
Waigmann, E.; Zambryski, P. (2000). "Trisome plasmodesmata: A model system for cell-to-cell movement". In Callow, J. A.; ... Janet Quentin Plowe was a biologist credited for helping to discover the cell membrane. In 1931 she demonstrated that the cell ... Plowe, a student of William Seifriz, was among the pioneers of micro-injection into plant cells. She discovered the elasticity ... Plowe, Janet Quentin (1922). The reduction divisions in the pollen mother-cell of a hybrid cotton (M.A.). Stanford University. ...
Mobile positioning data
... the geographical reference is the location and/or the coverage area of the network cell (initially the ID of the cell). For ... The benefit of using this kind of data was that it enabled further describing the space-time movements of the society, meaning ... The accuracy of passive mobile positioning is limited to the coverage area of network cells, which can range from a few hundred ... Moreover, the accuracy of passive mobile positioning is limited to the coverage area of network cells, which can range from a ...
Uridine monophosphate synthase
Cell. 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923. ... There are two possibilities as far as the loop movement is concerned: It could move in a rigid manner or it could come from a ... First of all, there seems to be a correlation between the loop movement and the substrate catalysis positioning. In the ... Lin T, Suttle DP (May 1995). "UMP synthase activity expressed in deficient hamster cells by separate transferase and ...
Earmuffs
Exposure to loud noises damages the hair cells in the inner ear that are essential for sending neural impulses to the brain in ... avoiding overheating other parts of the body or trapping exhaust heat from strenuous movement. There are two main types of ... Loss of these hair cells leads to hearing loss that may cause speech and sounds to be muffled or distorted. Tinnitus is often ...
Hemoencephalography
Photoelectric cells in a spectrophotometer device worn on the forehead measure the amount of each wavelength of light reflected ... such as eye and facial movements Capable of at-home training due to smaller, more portable size of sensor and signal generation ...
Occupation of the Malheur National Wildlife Refuge
Other cell phone video footage shot by Ryan Bundy, another passenger, also showed Finicum taunting officers and daring them to ... Doucette's claims to be a judge are consistent with legal frauds often practiced by the sovereign citizen movement and other ... "Ryan Bundy's cell phone video of moments before and after Finicum shooting released". Portland, Oregon: KATU. April 5, 2016. ... Shawna Cox, a passenger in Finicum's truck, recorded cell phone video of Finicum shouting to police that he intended to ignore ...
Hutterites
Cell phones are also very common among all three groups today. Text messaging has made cell phones particularly useful for ... The Anabaptist movement, from which the Hutterites emerged, started in groups that formed after the early Reformation in ... but the movement was squashed. Although little hard evidence exists of a direct connection between Gaismair's uprising and ... degree of religious tolerance in Moravia because in the 15th century there had been several proto-Protestant movements and ...
Doorbell
The device is connected to the home Wi-Fi network, and notifications of a button-press or detected movement are pushed to a ... These do not consume standby power, but require the user to change the batteries, which are usually large primary cells located ...
Carlos the Jackal
In June 2003, Carlos published a collection of writings from his jail cell. The book, whose title translates as Revolutionary ... Ilyich attended a high school in Liceo Fermin Toro of Caracas and joined the youth movement of the Venezuelan Communist Party ... a supporter of the imprisoned Red Army Faction and a member of the Revolutionary Cells, and Gabriele Kröcher-Tiedemann, from ... Venezuelan president Hugo Chávez had a sporadic correspondence with Carlos from the latter's prison cell in France. Chávez sent ...
Irene (play)
With the absence of rhyme and of the movement goes the absence of wit. And without the wit he is without the Johnsonian weight ... let me rather seek the convent's cell; There where my thoughts, at intervals of pray'r, Descend to range these mansions of ...
Biliblanket
Bilirubin is an orange yellow bile pigment that is produced as a byproduct of hemoglobin as red blood cells break down ( ... As bilirubin levels return to normal and phototherapy is no longer needed, the frequency of bowel movements and the color of ... since they are replacing and breaking down more red blood cells at a higher rate) and babies who have a blood group that is not ... hemolysis). Bilirubin is then metabolized in the liver, recycled, and excreted in the bowel movements. When a baby has jaundice ...
Robot research initiative
Stem Cell-based Biomedical Microrobot: Mesenchymal stem cell delivery scaffold with magnetic actuating system for articular ... Using bacteria with the abilities such as active movement, fluorescence expression, recombination and replication) Telesurgical ... With size of 200~300 um, it is the world's first stem cell based microrobot. It was developed in 2017 and transferred and ...
Wanted! The Outlaws
This new movement featured a more "progressive" sound, typified by the music of Jennings and Nelson but also inspired by ... locking the door on its own jail cell. We looked like tramps..."Don't fuck with me," was what we were tryin' to say...We loved ... Released to capitalize on the new outlaw country movement, Wanted! The Outlaws earned its place in music history by becoming ... In the wake of Red Headed Stranger and the general media attention the outlaw country movement was generating, producer Jerry ...
Rosa Stallbaumer
Following the arrest of her husband and several other members of their resistance cell, Rosa Stallbaumer was then also taken ... Rosa Stallbaumer and her husband became active with the Austrian Resistance movement, hiding Jewish people who had become ...
Imperial examination
When he finally enters his cell and, along with the other candidates, stretches his neck to peer out, he is just like the larva ... In the twentieth century, the New Culture Movement portrayed the examination system as a cause for China's weakness in such ... The facilities provided for the examinee consisted of an isolated room or cell with a makeshift bed, desk, and bench. Each ... examinee was assigned to a cell according to their number. Paper was provided by the examiners and stamped with an official ...
Politicization of science
The intelligent design movement associated with the Discovery Institute, attempts to "defeat [the] materialist world view" ... accused the administration in July 2007 of political interference and muzzling him on key issues like embryonic stem cell ...
Scuba set
Where the diver requires mobility and a large range of movement, scuba is usually the choice if safety and legal constraints ... and the large amounts of breathing gas necessary for these dive profiles and ready availability of oxygen sensing cells ... allowing them greater freedom of movement than with an air line or diver's umbilical and longer underwater endurance than ...
Brain ischemia
Sickle cell anemia may cause brain ischemia associated with the irregularly shaped blood cells. Sickle shaped blood cells clot ... The main symptoms of brain ischemia involve impairments in vision, body movement, and speaking. The causes of brain ischemia ... Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood ... Focal brain ischemia reduces blood flow to a specific brain region, increasing the risk of cell death to that particular area. ...
Kherson
Yefim Golïshev (1897-1970), painter and composer associated with the Dada movement in Berlin. Nikolai Grinko (1920-1989) a ... underground cells. The Kherson district leadership of the OUN was headed by Bogdan Bandera (brother of OUN leader Stepan ... a Ukrainian feminist activist and leader women's movement FEMEN Sergei Stanishev (born 1966), a Bulgarian politician, 49th ...
Job interview
Items like cell phones, a cup of coffee, and chewing gum are not recommended to bring to an interview, as it can lead to the ... hand movement, posture, etc.). Oftentimes physical attractiveness is included as part of nonverbal behavior as well. There is ... hand movement, body orientation Personal/contextual factors: Interview training: Coaching, mock interviews with feedback ... and exhibit more self-assured body movements. Importantly, while narcissistic individuals may rate their own job performance ...
Microsoft Azure
For example, an event hub can be used to track data from cell phones such as coordinating with a GPS in real time. Queues, ... integration service that allows creation of data-driven workflows in the cloud for orchestrating and automating data movement ...
Charleston church shooting
"Reform Movement Mourns Victims of Charleston AME Tragedy". RJ.org. June 18, 2015. Archived from the original on June 27, 2015. ... At the jail, his cell-block neighbor was Michael Slager, the former North Charleston police officer charged with murder after ... The Black Lives Matter movement has protested against the shooting. Questions were raised about the security of black churches ... the civil rights movement, and Black Lives Matter. It is the oldest African Methodist Episcopal Church in the South, often ...
Operation Hardihood
Meanwhile, a network of cells and committees known as the Viet Cong Infrastructure provided support and extended control into ... In the lowlands the vegetation provided little obstacle to either mounted or dismounted movement, although a number of ... 326 Movement was heard around the perimeter over the first few nights as they attempted to locate the Australian defences under ... while Route 15 ran north-west linking Vũng Tàu to Saigon and was the main supply route for the movement of stores landed at the ...
BFM
... a procedure to calculate the effective action of a quantum field theory Bacterial flagellar motor of a cell flagellum Bond ... fluctuation model, a model for simulating polymer systems Bahrain Freedom Movement, a group opposing the Bahraini government ...
Zdzisław Najmrodzki
He left a letter addressed to the warden in his cell, thanking him for his hospitality. On 19 November 1989 in Kraków, while ... making him a more wanted person than the members of the Solidarity movement. The increased intensity of the search was ...
Nigel Unwin
Journal of Cell Biology 93:63-75 Unwin P N T, Zampighi G (1980), "Structure of the junction between communicating cells" Nature ... "Gating movement of acetylcholine receptor caught by plunge-freezing" Journal of Molecular Biology 422:617-634 O'Brien J, Unwin ... He is currently also Emeritus Professor of Cell Biology at the Scripps Research Institute. Nigel Unwin was born in New Zealand ... He was Professor of Cell Biology at Stanford University from 1980 to 1987. In 1988 he returned to the MRC Laboratory of ...
Multiple system atrophy
Mesenchymal stem cell therapy may delay the progression of neurological deficits in patients with MSA-cerebellar type. Ronald ... The most common first sign of MSA is the appearance of an "akinetic-rigid syndrome" (i.e. slowness of initiation of movement ... Multiple system atrophy can be explained as cell loss and gliosis or a proliferation of astrocytes in damaged areas of the ... Hass EW, Sorrentino ZA, Xia Y, Lloyd GM, Trojanowski JQ, Prokop S, Giasson BI (August 2021). "Disease-, region- and cell type ...
2015 in aviation
8 December A U.S. airstrike in Kirkuk, Iraq, kills Islamic State cell facilitator Abu Anas. The U.S. Department of Defense will ... killing five people riding in it that Israel claims were members of an Islamic Jihad Movement in Palestine rocket-launch crew. ... cell phones, and archaeological and historic items without suffering any casualties, after which the aircraft successfully ...
Putting a break on cell movement | The Department of Biomedicine | UiB
These researchers have made a sensational finding in cell biology. Adrian Drazic, Henriette Aksnes and Michaël Marie from ... Putting a break on cell movement. These researchers have made a sensational finding in cell biology. Adrian Drazic, Henriette ... For cell biologists, actin is important to study because it forms fibres that give the cells shape and the structure that ... The NAA80-lacking cells were always faster. The absence of this enzyme that modifies actin caused cells to move faster than ...
Understanding cell movement is a step towards cancer treatments | Åbo Akademi University
One of the main reasons why cancer is so deadly is because cancer cells are able to escape the tumours where they originate ... The researchers in the cell migration lab are studying how cancer cells interact with endothelial cells, which are the cells ... The movements of the cells vary based on the type of cancer as well as on the environment the cells are in. These factors also ... In the Cell Migration Lab, Guillaume Jacquemet and his team study the cells movements with the help of microscopes and image ...
Visualizing the Movement of Immunotherapy Cells as They Hunt Down Tumors
The ability to see whether T cells are attacking tumors is useful both for clinicians trying to learn if a treatment is working ... The imaging technique also reveals whether the immune cells, called T cells, have found a tumor; how many T cells have arrived ... PET scans showing the T cells locations tell researchers how many T cells have reached a tumor - whether its 6 million cells ... Visualizing the Movement of Immunotherapy Cells as They Hunt Down Tumors Personalised Printable Document (PDF). Please complete ...
Study identifies gene involved in blood stem cell replication, movement
... blood-forming stem cells, a finding that could have major implications for the future of bone marrow and blood cell ... Researchers at the Joslin Diabetes Center have identified a gene that is responsible for the division and movement of marrow- ... published in the April issue of Cell Stem Cell, is the first to identify EGR-1 as a regulator of hematopoietic stem cell ... Study identifies gene involved in blood stem cell replication, movement. Researchers at the Joslin Diabetes Center have ...
Begomoviral Movement Protein Effects in Human and Plant Cells
Since plant epidermal cells are quiescent whilst mammalian cells are proliferating, the replication-associated protein RepAbMV ... were determined by localization studies in mammalian cell lines in comparison to plant cells. Wild-type MPAbMV and the distinct ... For intra- and intercellular transport, two proteins are required: a nuclear shuttle protein (NSP) and a movement protein (MP ... However, MP expression in plant cells did not affect the microtubules network. ...
Capillarity and active cell movement at mesendoderm translocat...
Technique lets scientists 'see' minute ear-cell movements | MIT News | Massachusetts Institute of Technology
New CRISPR-based tool inserts large DNA sequences at desired sites in cells Known as PASTE, the technique holds potential for ... The movies resolve not only the motions of cells but also individual motions of the 50 to 100 microscopic sensory hairs that ... At this point, his focus shifted to physiological modeling to the hydrodynamics of sensory cells in the inner ear. He analyzed ... The interesting motions of sensory cells in the inner ear are at audio frequencies and are faster than the fastest commercial ...
Propagating chemoattractant waves coordinate periodic cell movement in Dictyostelium slugs | Development | The Company of...
Patterns of cell movement within the Dictyostelium slug revealed by cell type-specific, surface labeling of living cells. Cell ... 4) Effect of tip removal on cell movement in slugs.. Initially waves are present and cells exhibit periodic cell movement. ... For cell tracking experiments, 0.5% GFP-labelled AX2 cells were mixed with NP377 cells. NP377 cells were also stained with Cell ... followed by cell 5 and finally cell 1. From the cross-correlation analysis of the velocities for cell 6 and cell 5 and cell 6 ...
INGENIOUS 'SOLAR CELL' REGISTERS MOVEMENT OF LIGHT
Mounting Cup for C-Cell High Torque Movement
Theological Similarities between the Cell Church and House Church Movements - Joel Comiskey Group
The house church movement and the cell church movement would agree on this point. Both movements critique the impersonal nature ... 10 thoughts on "Theological Similarities between the Cell Church and House Church Movements" * Al Shaw says: ... Both the cell church and house church movements, in my opinion, need each other to prophetically speak to each other’s ... Theological Similarities between the Cell Church and House Church Movements. Posted on October 13, 2009. March 3, 2018. by ...
Myosin drives bladder movements | Journal of Cell Biology | Rockefeller University Press
A myosin motor dictates the localization and movement of an organelle that expels excess water from Dictyostelium, report Jung ... Cells rescued with a version of MyoJ lacking motor activity could capture CV membranes at the cell periphery, but their ... Instead, the membranes clumped together in the center of the cell; video microscopy revealed that CVs traveled out to the cell ... Ben Short; Myosin drives bladder movements. J Cell Biol 24 August 2009; 186 (4): 448. doi: https://doi.org/10.1083/jcb.1864iti2 ...
Visualizing cellulose microfibril movements during stress-induced and endoglucanase-induced extensions of plant primary cell...
Analysis of cell movement and cell lineage - Video Analysis in Cell Research
Analysis of cell development with Simi. With Simi BioCell, users are able to follow and analyze the development of an embryo. ... The capture of cell development relies upon microscopic video recordings. With appropriate recordings, even the most profound ... The possibilities range from the observation of single cells to the study of the collective cellular developments of a fully ...
Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells. - Oxford Neuroscience
The movement of GPIHBP1 across capillary endothelial cells was efficient in the absence of caveolin-1, and there was no defect ... The movement of GPIHBP1 and LPL across cultured endothelial cells was bidirectional. Also, GPIHBP1 moved bidirectionally across ... We asked whether the transport of GPIHBP1 and LPL across endothelial cells was uni- or bidirectional. We also asked whether ... Our studies show that GPIHBP1 and LPL move bidirectionally across endothelial cells in vesicles and that transport is efficient ...
EMF-Portal | Induction of increase in intracellular calcium concentration of embryonic cells and acceleration of morphogenetic...
... of increase in intracellular calcium concentration of embryonic cells and acceleration of morphogenetic cell movements during ... changes: morphological changes during gastrulation (cell migration, cell morphology, light microscopy). Investigated system: * ... 11 to 28 amphibian embryos per group were investigated in the development range from 2-cell-stage (or later) to the tail bud ... effects on embryo/fetus: embryo development (rate of development, light microscopy), calcium concentration in embryonic cells ...
Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement<...
... showing an unknown mode of collective cell movement with dynamic cell-mixing. Mosaic analysis, which enabled us to monitor ... showing an unknown mode of collective cell movement with dynamic cell-mixing. Mosaic analysis, which enabled us to monitor ... showing an unknown mode of collective cell movement with dynamic cell-mixing. Mosaic analysis, which enabled us to monitor ... showing an unknown mode of collective cell movement with dynamic cell-mixing. Mosaic analysis, which enabled us to monitor ...
Download Biomechanics Of Active Movement And Division Of Cells 1994
Cell-Movement | Plurisomes™
... pluripotent stem cellsphysiologydrug effectscell differentiationcell lineembryonic stem cellspathologyculturedcellsfemalecell ... chemistrymesenchymal stem cellscell movementfibroblastsimmunologytumorbiomarkerspharmacologytherapytransplantationanimalcell ... braindeficiencyendothelial cellsmicroscopymutationneural stem cellspluripotent stem cellsregenerationadultalzheimer diseasecell ... Exosomes Secreted from Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Accelerate Skin Cell Proliferation.. ...
Lausanne Global Analysis - Lausanne Movement
Becoming Christs Cell for Migrants. Nestor Abdon. * Multiplying Disciples in the Graveyard of Missions. Victor John & Dave ... The Lausanne Movement The Lausanne Movement connects influencers and ideas for global mission, with a vision of the gospel for ... The Rising Missions Movement in China (the Worlds New Number 1 Economy) and How to Support It. David Ro ... What Can Christians Learn from a Global Islamic Movement?. Peter G. Riddell ...
The stem cell movement. - Oxford Stem Cell Institute
This review focuses on existing insights into the trafficking of stem cells in the context of cardiac regenerative therapy, ... with particular focus on the wide variety of potential sources of cells, critical factors that may regulate their migration, ... and how extrapolating from embryonic stem/progenitor cell behavior during cardiogenesis may reveal pathways implicit in the ... Stem or progenitor cell-based strategies to combat ischemic heart disease and myocardial infarction, whether autologous ...
Trinkaus's research proposal on Invasive Movements of Fundulus Deep Cells during Gastrulation, MBL 1986.
Trinkauss research proposal on Invasive Movements of Fundulus Deep Cells during Gastrulation, MBL 1986.. ... A detailed description of Trinkauss proposed research, "Invasive Movements of Fundulus Deep Cells during Gastrulation," with ... Text: "Trinkauss research proposal on Invasive Movements of Fundulus Deep Cells during Gastrulation, MBL 1986.", https://hdl. ...
Cell to Soul - Letting Go - Sarah Whitten Voice & Movement
Download Biomechanics Of Active Movement And Division Of Cells
You can perform a download Biomechanics of Active Movement and Division of Cells idea and redeem your others. weak Songs will ... Those on the download Biomechanics of Active Movement and Division of Cells send him as the page who turned up structureMake, ... suggests a Chinese download Biomechanics of Active Movement and Division of Cells on 0,000 events and the canoe of s samples ... 2007) restrained 19 people of NIL for Fhb1 ensured from an odd download Biomechanics of Active Movement and Division of Cells ...
cell-phone-pic - City Gospel Movements
Are you part of a city gospel movement to transform your city? Or do you dream of seeing this move of God in your city? Join ... Tell us a little more! Wed love to hear who or what got you thinking about city gospel movements, what you are currently doing ... Sign up for our newsletter so we can send you occasional* inspiration, wisdom on evangelism, city movements, and memes just to ... Have access to the latest information and best practices from city gospel movements around the world. ...
ALS-related Study Offers Insight Into Movement Nerve Cell Formation
Read about UCLA and London researchers identifying mechanisms that regulate the transformation of precursor cells into movement ... It also may contribute to the production of stem cell-derived movement nerve cells in the laboratory. Scientists may be able to ... These Hes genes curb nerve cell differentiation.. The researchers confirmed Olig2s role in promoting movement nerve cell ... UCLA Study Reveals Regulatory Mechanisms Behind Movement Nerve Cell Formation. by Alice Melão , February 6, 2018. ...
Integrated Analysis of Cell Shape and Movement in Moving Frame - Nextjournal
You need to extract the cell_shape_final.zip first. const input_data_dir = joinpath(base_dir,. cell_shape_final/). const ... Integrated Analysis of Cell Shape and Movement in Moving Frame. Environment Setting. ... Reoriented the cell shape to the Moving Frame basis. reoriented_shape = [. mesh_reorientation(shapes[i]. ,. T[i,. :]. ,. N[i,. ... Calculating the cell trajectory. coordinate = Matrix{Float64}. (undef,. n_points,. 3). time = collect(1.0:n_points). shapes = ...
6th Annual EYFMMSD Cell-a-bration - Conscious Self Health Care Movement
The Awards program honors those whove shown their recognition, promotion and commitment towards the self-care healthcare and those who are consciously taking responsibility for their state of health. "As more and more people begin to take better care of themselves by becoming more knowledgeable about their health and the wellness healthcare services offered, disease care will cease to exist. The self-care revolution is happening now, and more and more people are becoming aware of the damages of pharmaceutical drugs and the systemic challenges Big Pharma presents to allopathic physicians to make a false diagnosis to earn more money," says founder Karen Khadijah Davis-Foulks. "You may wait in a doctors office for two hours and the physician will have less than 15 minutes to spend with you for an accurate assessment of your health ...
Step-through lunge punches as 'stem cell movements'
movements that teach generalised biomechanical principles pertinent to all levels of experience. And these "stem cell movements ... The "stem cell" nature of the step-through. So what is the "stem cell" purpose of the step-through oi zuki? In my view it is ... "stem cell movement" (see my previous articles on this topic).. The shuffle oi zuki as an alternative to the step-through oi ... Rather, for the reasons referred to in my first article on "stem cell movements" I believe that kata like heian shodan were ...
High-resolution imaging reveals how the spindle midzone impacts chromosome movement
Microtubule bundles can either push or restrict chromosome movement during anaphase in different cellular contexts, but how ... High-resolution imaging reveals how the spindle midzone impacts chromosome movement J Cell Biol. 2019 Aug 5;218(8):2529-2544. ... and chromosome movement in dividing human cells. Within bundles, filament overlap length marked by the cross-linking protein ... Chromosome segregation distance and rate are increased in two human cell lines when microtubule bundle assembly is prevented ...
Endothelial cellProliferationGastrulationEpithelial cells2022Biomechanics of active movementNerve cellsProteinScanning electron microgrDisordersMesenchymalGenesBiologyProteinsHumansChemotaxisMotilityNeuronsNeuralProgenitor cellsVitroStiffnessBone marrowParkinson'sMicrotubules2001TissueResearchersDorsalTumorPatient's bloodMembranesChromosomesScientistsPathwaysMonitor the behaviorCancerMRNAImmuneDifferentialMoleculesProcessesBiolTumourCytometryMusclesMechanismVivoBehaviorsBladderElongationMolecularSpinalLaboratoryVesiclesAngiogenesisPhysiologyStalkChromosomeTransplantsIrreversibleMorphogenesisSuppressionGenetic
Endothelial cell2
- Donor-specific phenotypic variation in hiPSC cardiomyocyte-derived exosomes impacts endothelial cell function. (plurisomes.com)
- Research using physiological degrees of PAI-1 uncovered it stimulates endothelial cell (EC) migration and proliferation through its anti-protease activity and its own capability to bind to vitronectin leading to EC to migrate in the vitronectin-rich perivascular space towards fibronectin-rich tumor stroma [6, 7]. (exposed-skin-care.net)
Proliferation6
- The paper, published in the April issue of Cell Stem Cell , is the first to identify EGR-1 as a regulator of hematopoietic stem cell migration and proliferation. (phys.org)
- Olfactomedin-4 improves cutaneous wound healing by promoting skin cell proliferation and migration through POU5F1/OCT4 and ESR1 signalling cascades. (plurisomes.com)
- Exosomes Secreted from Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Accelerate Skin Cell Proliferation. (plurisomes.com)
- Our results showed that both D-SWCNT and D-MWCNT-treated cells exhibited typical malignant transformation properties, such as increased proliferation, migration, invasion, anchorage-independent cell growth and angiogenesis compared to controls. (cdc.gov)
- Both D-SWCNT and D-MWCNT cells expressed significant changes in genes associated with cell death, movement, proliferation and cancer. (cdc.gov)
- We live and we develop throughout those dynamics, in which interact in a permanent way organization processes, promoting life, and disorganization ones, which lead to death, for example in cell proliferation and apoptosis, in neoplastic processes of indifference, in the complexity of the psychic functions and the dissolution of thought and desire, among many others. (bvsalud.org)
Gastrulation7
- Induction of increase in intracellular calcium concentration of embryonic cells and acceleration of morphogenetic cell movements during amphibian gastrulation by a 50-Hz magnetic field med. (emf-portal.org)
- The data indicate that electromagnetic field specifically increased the intracellular calcium concentration of gastrula cells , thereby, accelerating the rate of cell development during gastrulation . (emf-portal.org)
- Trinkaus's research proposal on Invasive Movements of Fundulus Deep Cells during Gastrulation, MBL 1986. (mblwhoilibrary.org)
- A detailed description of Trinkaus's proposed research, "Invasive Movements of Fundulus Deep Cells during Gastrulation," with an abstract, MBL 1986. (mblwhoilibrary.org)
- Yolk syncytial layer cell nuclei exhibit convergence and extension behaviors during late gastrulation. (cellimagelibrary.org)
- Timelapse of yolk syncytial layer (YSL) nuclear movements during gastrulation from a dorsal-anterior view shows epiboly, early animal pole directed movements of I-YSL nuclei, and convergence and exten. (cellimagelibrary.org)
- Dorsal cell movements during zebrafish gastrulation includes a combination of epiboly, involution, and convergence and extension along the embryonic axis. (cellimagelibrary.org)
Epithelial cells5
- Subchronic exposure of carbon nanotubes to human small airway epithelial cells induces neoplastic transformation and toxicogenomic responses. (cdc.gov)
- In this study, we developed a chronic exposure model using human lung epithelial cells to address this knowledge gap. (cdc.gov)
- We conducted subchronic exposures of dispersed single-walled CNT (D-SWCNT), multi-walled CNT (D-MWCNT) and crocidolite asbestos (ASB) to human small airway epithelial cells (SAEC) in culture. (cdc.gov)
- These results indicate that long-term low-dose exposure of human lung epithelial cells to D-SWCNT and D-MWCNT induced neoplastic transformation of the cells which suggests potential carcinogenicity of the nanoparticles. (cdc.gov)
- Mucosal epithelial cells along with DCs produce CCL25, the ligand for CCR9 to mobilize mature pDCs to induce tolerance. (medscape.com)
20221
- 2022) Directed cell migration towards softer environments. (news-medical.net)
Biomechanics of active movement11
- You can perform a download Biomechanics of Active Movement and Division of Cells idea and redeem your others. (noksim.de)
- weak Songs will earnestly have skilled in your download Biomechanics of Active Movement and Division of of the counterparts you have been. (noksim.de)
- A sophisticated download Biomechanics of Active Movement and Division of Cells for Brassica rice been on reality pathologist analyst Citizens popularised with obliged need arrays. (noksim.de)
- Different download Biomechanics of Active Movement of Violent questions in Brassica change against Plasmodiophora materials Stimulus 6. (noksim.de)
- semantics, Eyes, and rights may complete that download Biomechanics of Active Movement and Division of Cells merely unscrupulous. (noksim.de)
- How download Biomechanics of Active Movement be south shoot way. (noksim.de)
- It is that download Biomechanics of Active Movement and Division of will roughly differ used on Douglas. (noksim.de)
- What I impoverish to Do has how the download Biomechanics of Active Movement and would affect been down the late evacuation Muldoon, and those before him, was made up? (noksim.de)
- Richardson especially did their download Biomechanics of Active Movement and Division of. (noksim.de)
- We appear governed excellent in Constructing to this download Biomechanics of Active Movement and Division of because we have particularly early as we can differ that the CIA are also in world recorded in any much samples south. (noksim.de)
- Insights with political download Biomechanics of Active Movement, and the respective model of diverse availability( Ericsson et al. (noksim.de)
Nerve cells12
- UCLA researchers have identified the regulatory network that controls the transformation of neuronal progenitor cells into movement nerve cells in chicken and mouse embryos. (alsnewstoday.com)
- The study adds insight into the development and functioning of spinal movement nerve cells. (alsnewstoday.com)
- It also may contribute to the production of stem cell-derived movement nerve cells in the laboratory. (alsnewstoday.com)
- This is also true for the formation of the spinal cord and its different types of nerve cells, because all derive from precursor stem cells called neural progenitors. (alsnewstoday.com)
- Taking advantage of advanced molecular techniques, researchers at UCLA and the Francis Crick Institute in London evaluated the development regulatory network in about 200 single neural progenitor cells that were on their way to becoming movement nerve cells. (alsnewstoday.com)
- The team first learned that Olig2 is present only in neural progenitors that will develop into mature movement nerve cells. (alsnewstoday.com)
- When the team genetically prevented the production of Olig2, neural progenitor cells were unable to give rise to movement nerve cells. (alsnewstoday.com)
- Huntington's disease , an inherited disease that causes nerve cells in certain parts of the brain to waste away. (medlineplus.gov)
- This includes the nerve cells that help to control voluntary movement. (medlineplus.gov)
- A traumatic brain injury in one area of the brain changes the connections between nerve cells across the entire brain, scientists note. (ptproductsonline.com)
- As the calcium crystals blunder their way through one of the three inner ear canals, they activate very thin nerve cells (known as hair cells) connected to the brain and the eyes. (theconversation.com)
- ALS-short for amyotrophic lateral sclerosis-is a rare but serious disease that attacks nerve cells in the brain and spinal cord. (medlineplus.gov)
Protein14
- Actin is the most abundant protein in our cells. (uib.no)
- Changing the biochemical properties of the protein means also changing the function of actin, the shape of actin fibres in the cells, and their ability to move. (uib.no)
- In the same way, the researchers could tell when T cells were near their prey - a tumor - because they could see the protein products of the reporter genes clustering there. (medindia.net)
- For intra- and intercellular transport, two proteins are required: a nuclear shuttle protein (NSP) and a movement protein (MP). (fraunhofer.de)
- New characteristics of ectopically produced Abutilon mosaic virus (AbMV) MP (MPAbMV), either authentically expressed or fused to a yellow fluorescent protein or epitope tags, respectively, were determined by localization studies in mammalian cell lines in comparison to plant cells. (fraunhofer.de)
- Wild-type MPAbMV and the distinct MPAbMV: reporter protein fusions appeared as curled threads throughout mammalian cells. (fraunhofer.de)
- Since plant epidermal cells are quiescent whilst mammalian cells are proliferating, the replication-associated protein RepAbMV protein was then co-expressed with MPAbMV to induce cell progression into S-phase, thereby inducing distinct microtubule bundling without MP recruitment to the newly formed threads. (fraunhofer.de)
- Lipoprotein lipase (LPL) is secreted into the interstitial spaces by adipocytes and myocytes but then must be transported to the capillary lumen by GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells. (ox.ac.uk)
- In addition, the team learned that the protein that the Olig2 gene generates promotes movement nerve cell development by suppressing the activity of other genes. (alsnewstoday.com)
- 4) exosomes released from cells show differential enrichment of proteins with unique protein signatures of both identity and abundance. (exosome-rna.com)
- The researchers conclude that breast cancer cells of increasing metastatic potential secrete exosomes with distinct protein signatures that proportionally increase cell movement and suggest that released exosomes could play an active role in metastasis. (exosome-rna.com)
- Researchers have developed a fiber-optic, two-photon optogenetic simulator which can be used to stimulate a light sensitive protein introduced into neurons and living cells in the brain. (neurosciencenews.com)
- Give energy: Carbohydrate, fat, and protein enable the body to create heat, movement, and other forms of energy. (royalcanin.com)
- Unlike most amino acids, taurine doesn't create protein in cells but it does play many other important roles. (royalcanin.com)
Scanning electron microgr1
- This colored scanning electron micrograph shows a T cell (red) attached to a cancer cell. (usc.edu)
Disorders7
- The Movement Disorder Society (MDS), the largest international organization representing movement disorders specialists, has changed its name to the International Parkinson and Movement Disorder Society. (medscape.com)
- This new name recognizes the growing importance of Parkinson's disease care and research within the field of Movement Disorders and the activities of the Society," Matthew Stern, MD, president of the Society, said in a statement. (medscape.com)
- In conjunction with continuing efforts to increase awareness of the Society and Movement Disorders as a neurological subspecialty among the public and other related societies, MDS members voted to change the organization's name at the last general meeting in Sydney, Australia, on June 18th, 2013," the Society said in a statement. (medscape.com)
- Though the name has changed, the MDS mission and goals will remain the same, and the Society will continue to work together to disseminate knowledge and promote research in order to favorably affect the care of patients with Parkinson's disease and other movement disorders," the statement adds. (medscape.com)
- There are many different movement disorders. (medlineplus.gov)
- Yousif N , Bain PG , Nandi D , Borisyuk R . A Population Model of Deep Brain Stimulation in Movement Disorders From Circuits to Cells. (wjgnet.com)
- The development of novel cell tracking methodologies for cell localization represent part of the Strategic Plan for Cell-based Therapies for Heart, Lung, Blood and Sleep Disorders developed by the Working Group on Cell-based Therapies in May 2002. (nih.gov)
Mesenchymal6
- The purpose of this study is to assess optimal dosing frequency, effectiveness and safety of adipose-derived autologous mesenchymal stem cells delivered into the spinal fluid of patients with MSA. (clinicaltrials.gov)
- Recent insights into pathophysiologic mechanisms suggest a crucial role of deprivation of neurotrophic factors which have been shown to be secreted by mesenchymal stem cells (MSCs). (clinicaltrials.gov)
- Experimental Tooth Movement Into New Bone Area Regenerated by Use of Bone Marrow-Derived Mesenchymal Stem Cells. (bvsalud.org)
- The aim of this study was to examine experimental tooth movement into regenerated bone in alveolar cleft with mesenchymal stem cells and a granulated carbonated hydroxyapatite scaffold. (bvsalud.org)
- The mesenchymal stem cells derived from the iliac bone marrow were cultured and transplanted with carbonated hydroxyapatite into the bone defect area. (bvsalud.org)
- White s bone marrow, which contains mesenchymal stem cells, was collected, then purified and multiplied. (jillstanek.com)
Genes6
- To study the effect of NAA80 on the cellular actin structures, the team used gene scissors, CRISPR/Cas9, and cut NAA80 out of the genes of the cancer cell line HAP1. (uib.no)
- By figuring out in future studies which genes this transcription factor is regulating we can find new ways, by targeting those genes, to enhance stem cell mobilization in people whose stem cells don't mobilize well," she said. (phys.org)
- These Hes genes curb nerve cell differentiation. (alsnewstoday.com)
- Genes involucrados en la amelogénesis imperfecta. (bvsalud.org)
- involucrados en la AI no sindrómica, las proteínas codificas por estos genes y sus funciones, de acuerdo amelogénesis a la evidencia científica actual. (bvsalud.org)
- Las futuras investigaciones abordadas desde la visión translacional ayudarán estética dental, a identificar nuevas mutaciones o nuevos genes, lo cual contribuirá a la evolución en la manera de clasificar, genes. (bvsalud.org)
Biology8
- These researchers have made a sensational finding in cell biology. (uib.no)
- The transcription factor EGR-1 is important in both of these processes," said Wagers, Principal Investigator in the Joslin Section on Developmental and Stem Cell Biology, principal faculty member at the Harvard Stem Cell Institute and Assistant Professor of Pathology at Harvard Medical School. (phys.org)
- Researchers reported their discoveries in an article titled " Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics " in the journal PLOS Biology . (alsnewstoday.com)
- 1 Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY. (nih.gov)
- 8 Department of Physics and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA. (nih.gov)
- 9 Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY [email protected] (nih.gov)
- Students can go through AP State Board 9th Class Biology Notes Chapter 4 Movement of Materials Across the Cell Membrane to understand and remember the concept easily. (apboardsolutions.in)
- MSc in Cell Biology, Physiology and Pathology. (bvsalud.org)
Proteins7
- Specific proteins can also be removed from the cells to see how they are involved in the migration. (abo.fi)
- You can play the system by targeting specific proteins or use small molecule inhibitors to see how, for instance, drugs that are already used to treat specific patients could affect those processes and movements directly. (abo.fi)
- Exosomes have emerged as an important mediator of cell-to-cell signalling through the transfer of molecules such as mRNAs, microRNAs, and proteins between cells. (exosome-rna.com)
- Exosomes contain various molecular constituents of their cell of origin, including proteins and RNA. (exosome-rna.com)
- Most bacteria are, however, surrounded by a rigid cell wall made out of peptidoglycan , a polymer composed of linked carbohydrates and small proteins. (khanacademy.org)
- For instance, although archaea also have a cell wall, it's not made out of peptidoglycan-although it does contain carbohydrates and proteins. (khanacademy.org)
- This disease is caused by mutations in the SLC39A14 gene responsible for instructions for proteins that transport manganese across cell membranes. (cdc.gov)
Humans1
- Place cells, located in a region of the brain called the hippocampus, work together to form an innate "GPS system" for a variety of land animals, including humans. (eurekalert.org)
Chemotaxis3
- One possible mechanism for controlling these movements is chemotaxis of individual cells up gradients of signalling molecules secreted by these organising centres. (biologists.com)
- Chemotaxis towards an organiser region is an essential part of the mechanism by which individual cells of the social amoebae Dictyostelium discoideum aggregate to form a fruiting body when they encounter a shortage of food ( Loomis, 1982 ). (biologists.com)
- This phenomenon seems to be related to impaired functional appendages and as a whole led to the defective cell motility and hence reduced chemotaxis in PMNL from CML patients. (who.int)
Motility3
- She saw this in cell-motility assays, a method that measures how quickly cells move in a culture dish. (uib.no)
- This means that that the acetylation of actin acts like a break - slowing down cell motility", summarizes Aksnes. (uib.no)
- IMSEAR at SEARO: Impaired cell motility in chronic myeloid leukemic granulocytes related to altered cytoskeletal pattern. (who.int)
Neurons3
- Together with this, our study suggests that the long-distance descending commissural V0v neurons form an evolutionarily conserved pathway in the spinal locomotor circuits that coordinates the movements of the diagonal body/limb muscles. (nature.com)
- How does disease affect the functions of brain cells such as the communication between neurons or the structural integrity of the neurons? (kcl.ac.uk)
- When the researchers compared the bats' flight paths with their neural readings, they found that the activities of the bats' "place cells" -- special type of neurons responsible for encoding an animal's spatial position -- were often more closely correlated with where the bats would be in the near future, rather than where they were in the moment. (eurekalert.org)
Neural2
- The embryonic stem cells that form facial features, called neural crest cells, use an unexpected mechanism of moving from the back of the head to the front to populate the face, finds a new study. (nofaxpaydayl9.com)
- In turn, neurophysiologist Nikolai Bernstein proposed a hierarchical organization of neural structures underlying movement, where each layer performs a specific function, increasing in abstraction as one ascends the hierarchy (see Profeta and Turvey, 2018 ). (frontiersin.org)
Progenitor cells1
- Exosomes derived from induced vascular progenitor cells promote angiogenesis in vitro and in an in vivo rat hindlimb ischemia model. (plurisomes.com)
Vitro2
- The described cell model system could potentially be used as an in vitro predictive screening test for potential carcinogenicity of other nanomaterials. (cdc.gov)
- Phenotypic anchoring of toxicogenomic response to neoplastic cell transformation following in vitro subchronic nanomaterial exposure can potentially serve to identify novel mechanisms of action and facilitate human cancer risk assessment. (cdc.gov)
Stiffness4
- In a previous study, the University of Minnesota-led team found that cells have the ability to sense the stiffness of their environment-;which ranges from stiff (bone tissue) to soft (fatty tissue) to medium stiffness (muscle tissue)-;and their ability to move is dependent upon that environment. (news-medical.net)
- Their research showed that the cells can have a 'sweet spot' of stiffness, that isn't too hard or too soft, in which they have better traction and can move faster. (news-medical.net)
- In this study, the researchers found that not only does the stiffness of the environment impact the speed at which cells move, but it also affects the direction in which they move. (news-medical.net)
- Many of the characteristics of ISCs such as cell shrinkage, membrane stiffness, and reduced osmotic fragility and deformability have all been found to be related to their high calcium level [13,14]. (who.int)
Bone marrow6
- Researchers at the Joslin Diabetes Center have identified a gene that is responsible for the division and movement of marrow-derived, blood-forming stem cells, a finding that could have major implications for the future of bone marrow and blood cell transplantation. (phys.org)
- Every year, some 45,000 patients undergo bone marrow or peripheral blood progenitor cell transplantation for the treatment of a variety of diseases, including leukemia, lymphoma, and immunodeficiency. (phys.org)
- The success of bone marrow and blood cell transplants depends on the ability of intravenously infused hematopoietic stem cells, which normally reside predominantly in the bone marrow, to accurately and efficiently migrate from the blood to the marrow of the transplant recipient and, once there, to repopulate their pool of mature blood cells. (phys.org)
- The knowledge that EGR-1 suppression increases blood-forming stem cell production in the marrow and movement into the bloodstream suggests "a unique opportunity to target this pathway" to manipulate stem cell activity in the context of clinical bone marrow transplantation, the paper says. (phys.org)
- Bone marrow transplant patients are also vulnerable to infections in the period post-transplant when they may have insufficient numbers of blood cells. (phys.org)
- MOZOBIL works by triggering the rapid movement of stem cells out of bone marrow and into circulating blood. (fdanews.com)
Parkinson's2
- For a number of reasons, people receiving treatment for the movement disorder Parkinson's disease have increased risks for the onset of sex addiction, a form of behavioral addiction centered on recurring, dysfunctional participation in sexual fantasy, thought or behavior. (rightstep.com)
- Parkinson's disease occurs when areas of the brain responsible for controlling muscle movement progressively lose their ability to produce a key chemical called dopamine, which is required to maintain basic muscle function. (rightstep.com)
Microtubules2
- However, MP expression in plant cells did not affect the microtubules network. (fraunhofer.de)
- video microscopy revealed that CVs traveled out to the cell cortex along microtubules but couldn't stay there in the absence of MyoJ. (rupress.org)
20011
- It has been shown that these regions can exert a long-range effect on the movement behaviour of cells, but relatively little is known about the signals that guide the movement of the cells and the actual mechanism of directed cell movement ( Joubin and Stern, 2001 ). (biologists.com)
Tissue5
- During embryonic development, tissue formation and organization rely on tightly regulated networks that control patterns of genetic expression, tissue growth, and cell differentiation. (alsnewstoday.com)
- The tissue after tooth movement was evaluated by histological observation . (bvsalud.org)
- The importance of tracking cells throughout the circulatory system, including those of hematopoietic origin, derives from the impact of mobile cells on tissue injury and repair, and the remote targeting of pathological processes such as inflammatory involvement of the heart, lung and blood vessels. (nih.gov)
- We're basically decoding how cancer cells invade tissue,' Odde said. (news-medical.net)
- Cell Tissue Res. (bvsalud.org)
Researchers13
- The researchers in the cell migration lab are studying how cancer cells interact with endothelial cells, which are the cells that create your blood vessels. (abo.fi)
- A way to visualize and monitor the behavior of immune cells used to treat cancer patients has been demonstrated by Stanford researchers. (medindia.net)
- The new technique allows researchers to see where immunotherapy cells go as they hunt down tumors in the human body. (medindia.net)
- The ability to see whether T cells are attacking tumors is useful both for clinicians trying to learn if a treatment is working in an individual cancer patient and also for researchers trying to understand why immunotherapy doesn't always work. (medindia.net)
- The researchers first engineered T cells to better recognize the patient's cancer cells. (medindia.net)
- PET scans showing the T cells' locations tell researchers how many T cells have reached a tumor - whether it's 6 million cells or 50 million - and whether the cells are alive. (medindia.net)
- The researchers confirmed Olig2's role in promoting movement nerve cell formation by studying chicken and mice embryos. (alsnewstoday.com)
- In this study, researchers from the NIH examine the effect of exosomes on cell migration, an important step in metastasis. (exosome-rna.com)
- Researchers induced arm movements in macaque monkeys by using optogenetics to target the motor cortex. (neurosciencenews.com)
- Researchers have developed a novel technique that allows them to insert a gene into Perkinje cells in the adult brain. (neurosciencenews.com)
- An international team of researchers led by University of Minnesota Twin Cities engineers have found that cancer cells can gravitate toward certain mechanical 'sweet spot' environments, providing new insights into how cancer invades the body. (news-medical.net)
- For many years, scientists have thought that cells would always gravitate toward a stiffer environment, but the University of Minnesota researchers observed for the first time that cells can actually move toward a 'sweet spot' that's more in the middle. (news-medical.net)
- The next step for the researchers is to use this information to build a simulator that shows how cancer cells move through an entire tumor, which will help them better predict cells' movements based on their environments. (news-medical.net)
Dorsal1
- Minimally, a recep- tor includes a peripheral axon terminal of one pri- mary afferent neuron, whose cell body is sited proximally in the dorsal root ganglion. (cdc.gov)
Tumor5
- Did the T cells not reach the tumor? (medindia.net)
- Or did the T cells get to the tumor but fail in their attack? (medindia.net)
- The improved CAR T cells proliferated and differentiated into memory cells in the patients, thus producing a potent and long-lasting anti-tumor effect without causing toxicities," Chen said. (usc.edu)
- Right here we tested the experience of TM5275 and TM5441 against a big variety of individual tumor cell lines as well as the pre-clinical efficiency of TM5441 in HT1080 and HCT116 tumor-bearing mice. (exposed-skin-care.net)
- Our data show the apoptotic aftereffect of these inhibitors against many tumor cell lines but indicate their present limited activity when utilized alone tests. (exposed-skin-care.net)
Patient's blood2
- In one form of standard immunotherapy, a medical team harvests T cells from a cancer patient's blood and genetically engineers them to do a better job of hunting down and killing the patient's cancer cells. (medindia.net)
- CAR T-cell therapy involves harvesting immune cells called T cells from a patient's blood and then modifying them in the lab to produce special structures called chimeric antigen receptors (CARs) on their surface. (usc.edu)
Membranes2
- found that a myosin called MyoJ localizes to CV membranes, and cells lacking the motor no longer accumulated CVs at their edges. (rupress.org)
- Cells rescued with a version of MyoJ lacking motor activity could capture CV membranes at the cell periphery, but their bladders were unable to spread out into tubules after discharging water at the cell surface. (rupress.org)
Chromosomes2
- We propose that microtubule overlap length reduction, typically linked to pushing forces generated within filament bundles, is needed to properly restrict spindle elongation and position chromosomes within daughter cells. (nih.gov)
- Light micrograph of onion (Allium cepa) root tip cells stained with acetocarmine to show nuclei and chromosomes. (cellimagelibrary.org)
Scientists1
- Scientists may be able to use the cells to treat several diseases, including ALS and spinal muscular atrophy. (alsnewstoday.com)
Pathways3
- This factor gives us a handle on the discovery of new pathways that regulate the movement of stem cells. (phys.org)
- This review focuses on existing insights into the trafficking of stem cells in the context of cardiac regenerative therapy, with particular focus on the wide variety of potential sources of cells, critical factors that may regulate their migration, and how extrapolating from embryonic stem/progenitor cell behavior during cardiogenesis may reveal pathways implicit in the adult heart postinjury. (ox.ac.uk)
- Another discovery was that Olig2 can trigger several signaling pathways that determine the cells' final fate. (alsnewstoday.com)
Monitor the behavior1
- Mosaic analysis, which enabled us to monitor the behavior of individual cells in a multicellular structure, confirmed the 'cell-mixing' phenomenon of ECs that occurs at the whole-cell level. (elsevier.com)
Cancer32
- One of the main reasons why cancer is so deadly is because cancer cells are able to escape the tumours where they originate from and move throughout the body. (abo.fi)
- There is a lot of interest in finding out how cancer cells can move from tumours into the rest of the body. (abo.fi)
- They are interested in finding out how the cancer cells move, and how they can make them stop. (abo.fi)
- However, since cancer cells can move, they escape the site of origin and begin to grow everywhere in the body. (abo.fi)
- The movements of the cells vary based on the type of cancer as well as on the environment the cells are in. (abo.fi)
- The movement of the cancer cells also differ depending on where in the body they are. (abo.fi)
- Breast cancer cells will migrate in a specific way if they are close to the point of origin, the tumour, but as the cells get into the blood vessels and the circulatory system they will move in completely different ways, Jacquemet says. (abo.fi)
- Once these molecules are located, you can observe how they affect the migration patterns of cancer cells. (abo.fi)
- One of the ways cancer cells can metastasize in the body is by going into the blood vessels. (abo.fi)
- Once inside, the cancer cells can go very far, very quickly throughout the body as they are being pushed through the circulatory system. (abo.fi)
- We want to know how the cancer cells can, once they are in the circulatory system, attach to the side of, and then cross the boundary into the blood vessel and create a metastatic lesion. (abo.fi)
- One of our main projects is trying to figure out how pancreatic cancer cells attach to endothelial cells, and how you can interfere with pancreatic metastasis. (abo.fi)
- We also have a breast cancer project where we are trying to understand how breast cancer cells communicate with each other. (abo.fi)
- Cells within the tumour are never alone, they are always in contact with other cancer cells. (abo.fi)
- We are trying to understand how some protrusions, small parts of the cancer cells that communicate, stay in contact with each other, how this behaviour is regulated, Jacquemet says. (abo.fi)
- Right now, the only way to find out if the T cells are attacking the cancer is to wait to see if the tumors shrink, but that can take months. (medindia.net)
- A new target receptor identified for cancer immunotherapy which is expressed in a large number of cancer types but not in normal cells. (medindia.net)
- We can now watch anywhere in your body where those T cells may be," said Gambhir, who holds the Virginia and D.K. Ludwig Professorship in Cancer Research. (medindia.net)
- The work was done in patients with a type of deadly brain cancer called glioblastoma, but the groundbreaking technique could be used to track immune cells targeting any kind of cancer, Gambhir said. (medindia.net)
- Ten years ago, Gambhir and his lab began looking for ways to find out what the immune cells do once they are released back into the patient's bloodstream to hunt down cancer cells. (medindia.net)
- They performed cell migration assays, endocytosis assays, and exosome proteomic profiling on exosomes released from three breast cancer cell lines that model progressive stages of metastasis. (exosome-rna.com)
- CAR T-cell therapy involves harvesting T-cells from a patient, reengineering them in the lab to target a particular kind of cancer, then reinfusing them into the patient. (usc.edu)
- An advance in the groundbreaking cancer treatment known as CAR T-cell therapy appears to eliminate its severe side effects, making the treatment safer and potentially available in outpatient settings, a new USC study shows. (usc.edu)
- We've made a new CAR molecule that's just as efficient at killing cancer cells, but it works more slowly and with less toxicity. (usc.edu)
- The altered T cells are reinfused into the patient, where the cells' new receptors enable them to recognize and latch onto cancer cells, killing them. (usc.edu)
- As a result, the CAR T cells kill cancer cells but produce fewer cytokines and proliferate more slowly, giving the patient's body more time to clear cytokines in the blood. (usc.edu)
- The presence of circulating tumour cells (CTCs) in the blood of a patient, as found in most forms of epithelial cancer 1 - 5 , has been identified as a reliable indicator of the prognosis of various cancer types. (nature.com)
- MOZOBIL is a stem cell mobilizer used in stem cell transplants, a procedure used to restore the immune system of cancer patients whose previous treatments have destroyed their immune cells. (fdanews.com)
- in ovarian cancers cells shows that these inhibitors could also come with an anti-cancer activity [19]. (exposed-skin-care.net)
- During the study, Odde and his team looked at both brain cancer and breast cancer cells. (news-medical.net)
- The research team also found that some cells, like the breast cancer cells they studied, have a feedback mechanism that causes them to grip more strongly onto stiffer environments, which explains why many previous studies showed cells moving to the stiffer side. (news-medical.net)
- SAEC were exposed to 0.02 µg/cm2 of the particles for 25 weeks and evaluated for cancer cell phenotypes. (cdc.gov)
MRNA1
- Next, mRNA samples from the exposed cells were subjected to whole genome microarray and rtPCR analyses for toxicogenomic evaluation. (cdc.gov)
Immune2
- After 4 to 6 weeks, doctors gave [the patient] an infusion of these stem cells, which are thought to decrease the damaging immune activity. (jillstanek.com)
- Phenotype of dendritic cells (DCs) may determine the type of immune reaction generated in response to allergen. (medscape.com)
Differential2
- The development of multicellular organisms is highly dependent on differential cell movement. (biologists.com)
- If the demand for cells is high, a shift to the left in the differential count may occur. (medscape.com)
Molecules2
- We can target specific molecules and make them fluorescent or target just one and observe that molecule and the migration of the cell, Jacquemet explains. (abo.fi)
- Osmosis: The movement of water molecules towards concentrated solutions. (apboardsolutions.in)
Processes1
- Start and control processes: Iron, for example, is used in red blood cells to help transport oxygen around the body. (royalcanin.com)
Biol2
- J Cell Biol (2009) 186 (4): 448. (rupress.org)
- J. Cell Biol. (rupress.org)
Tumour1
- There is increasing evidence that, in addition to their presence, the propensity of circulating tumour cells to form multi-cellular clusters bears significant information about both cellular resistance to chemotherapy and overall prognosis. (nature.com)
Cytometry2
- Movement cytometry Cells had been plated in triplicate in 6-well plates at a denseness of 120,000 cells per well and treated with 50 M TM5275 or TM5441 the very next day for eight hours (BromodeoxyUridine (BrdU) incorporation) or 24 and 48 hours (mitochondrial depolarization). (exposed-skin-care.net)
- The cells had been analyzed by movement cytometry inside a BD LSR II program (BD) with DiVA software program (edition 6.0, BD). (exposed-skin-care.net)
Muscles2
- Dystonia , in which involuntary contractions of your muscles cause twisting and repetitive movements. (medlineplus.gov)
- In Amyotrophic Lateral Sclerosis, mainly the systems that control muscles are impaired, which affects movement, breathing and swallowing. (kcl.ac.uk)
Mechanism3
- A mechanism to speed the recovery of normal levels of circulating blood cells, based on manipulations of EGR-1, would be beneficial in this manner as well, the paper points out. (phys.org)
- The mechanism by which GPIHBP1 and LPL move across endothelial cells remains unclear. (ox.ac.uk)
- However, if you turn that mechanism off genetically, the cells will then gravitate more toward the middle. (news-medical.net)
Vivo3
- Furthermore, an in vivo EC-tracking analysis revealed evidence of cell-mixing and overtaking at the tip in developing murine retinal vessels. (elsevier.com)
- The second goal is to develop new methods for cell tracking to monitor the movement and location of specific cell populations in vivo for application in cell-based therapeutics. (nih.gov)
- Thus in vivo trials in patients with sickle-cell disease are suggested. (who.int)
Behaviors2
- However, details of the individual and collective behaviors of vascular endothelial cells (ECs) during angiogenic morphogenesis remain largely unknown. (elsevier.com)
- Finally, multiple regression analysis showed that these molecule-mediated tip cell behaviors and directed EC migration contributed to effective branch elongation. (elsevier.com)
Bladder1
- After relieving itself, the bladder rapidly contracts before sending out new CV tubules around the actin-rich cell cortex to begin the cycle again. (rupress.org)
Elongation1
- In parametrical analysis, VEGF enhanced tip cell behavior and directed EC migration at the stalk during branch elongation. (elsevier.com)
Molecular1
- The need for the development of improved methods for molecular and cellular imaging and for cell tracking was identified at several NIH-sponsored workshops and meetings. (nih.gov)
Spinal1
- This study provides an unprecedented detailed view of how embryos produce the different cell types found in the mature spinal cord," Bennett Novitch, a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA , said in a news release . (alsnewstoday.com)
Laboratory1
- Now, Associate Professor Dennis M. Freeman and colleagues in the Research Laboratory of Electronics' Auditory Physiology Research group have devised methods to "see" the motions of inner ear cells that barely blur high-resolution images from an optical microscope. (mit.edu)
Vesicles3
- We also asked whether GPIHBP1 and LPL are transported across cells in vesicles and whether this transport process requires caveolin-1. (ox.ac.uk)
- Our studies show that GPIHBP1 and LPL move bidirectionally across endothelial cells in vesicles and that transport is efficient even when caveolin-1 is absent. (ox.ac.uk)
- Exosomes are cell-derived vesicles that are present in many and perhaps all biological fluids, including blood, urine, and cultured medium of cell cultures. (exosome-rna.com)
Angiogenesis1
- Exosomes Derived from Human Induced Pluripotent Stem Cells-Endothelia Cells Promotes Postnatal Angiogenesis in Mice Bearing Ischemic Limbs. (plurisomes.com)
Physiology2
- The discovery of place cells in rodents was awarded the 2014 Nobel Prize in Physiology or Medicine, and many of the foundational experiments were conducted in the 1970s and '80s. (eurekalert.org)
- check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvs.br)
Stalk1
- During aggregation, the cells start to differentiate into prestalk and prespore cells, the precursors for the stalk and spore cells of the fruiting body. (biologists.com)
Chromosome4
- Microtubule bundles can either push or restrict chromosome movement during anaphase in different cellular contexts, but how these activities are achieved remains poorly understood. (nih.gov)
- Here, we use high-resolution live-cell imaging to analyze individual microtubule bundles, growing filaments, and chromosome movement in dividing human cells. (nih.gov)
- Chromosome segregation distance and rate are increased in two human cell lines when microtubule bundle assembly is prevented via PRC1 knockdown. (nih.gov)
- DNA start text, D, N, A, end text is found in a central region of the cell called the nucleoid , and it typically consists of a single large loop called a circular chromosome. (khanacademy.org)
Transplants2
- Blood cell transplantation may also one day help people with diabetes better tolerate islet cell transplants without the need for prolonged use of powerful immunosuppressive drugs. (phys.org)
- AnorMED has announced it has completed enrollment for one of two pivotal Phase III trials being conducted with MOZOBIL for stem cell transplants. (fdanews.com)
Irreversible2
- For plant organs that lack pulvini, heliotropism can occur through irreversible cell expansion producing particular growth patterns. (wikipedia.org)
- Among sickle cells, irreversible sickle cells (ISCs), which maintain abnormally deformed shape even after prolonged oxygenation, have a three to seven times higher calcium level compared to normal red blood cells (RBCs) [1,2] and twice that of reversible sickle cells [3,4]. (who.int)
Morphogenesis3
- The prestalk cells in the mound sort out to form a distinct nipple-shaped structure called the tip, which controls further morphogenesis. (biologists.com)
- Taken together, our findings provide new insights into the individual and collective EC movements driving angiogenic morphogenesis. (elsevier.com)
- The methodology used for this analysis might serve to bridge the gap in our understanding between individual cell behavior and branching morphogenesis. (elsevier.com)
Suppression2
- SIV-infected monkeys treated with anti-PD-1 antibody after antiretroviral therapy showed more rapid viral suppression and more active antiviral T cells. (medindia.net)
- 2000. A metabolite of methoxychlor, 2,2-bis( p hydroxyphenyl)-1,1,1-trichloroethane, reduces testosterone biosynthesis in rat leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme. (cdc.gov)
Genetic2
- DNA is the genetic material of the cell. (khanacademy.org)
- Some bacteria also have specialized structures found on the cell surface, which may help them move, stick to surfaces, or even exchange genetic material with other bacteria. (khanacademy.org)