Cell Migration Inhibition: Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES. Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms.Leukocyte Migration-Inhibitory Factors: Protein factor(s) released by sensitized lymphocytes (and possibly other cells) that inhibit the movement of LEUKOCYTES, especially polymorphonuclear cells, away from their site of release. Assays for these factors are used as tests for cellular immunity. Two of the common assays are the LEUKOCYTE MIGRATION CAPILLARY TUBE TECHNIQUE (LMCT) and the LEUKOCYTE MIGRATION AGAROSE TEST (LMAT).Macrophage Migration-Inhibitory Factors: Proteins released by sensitized LYMPHOCYTES and possibly other cells that inhibit the migration of MACROPHAGES away from the release site. The structure and chemical properties may vary with the species and type of releasing cell.Immunity, Cellular: Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.Leukocytes: White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Tuberculin: A protein extracted from boiled culture of tubercle bacilli (MYCOBACTERIUM TUBERCULOSIS). It is used in the tuberculin skin test (TUBERCULIN TEST) for the diagnosis of tuberculosis infection in asymptomatic persons.Cell Migration Assays, Leukocyte: Assays that measure the rate of migration of LEUKOCYTES. They may involve a variety of techniques such as measuring the movement of leukocytes through substrates such as AGAROSE gels or the rate of exit of cells from a glass capillary.Hypersensitivity, Delayed: An increased reactivity to specific antigens mediated not by antibodies but by cells.Transfer Factor: Factor derived from leukocyte lysates of immune donors which can transfer both local and systemic cellular immunity to nonimmune recipients.Skin Tests: Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.Antigens: Substances that are recognized by the immune system and induce an immune reaction.Lymphocytes: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Guinea Pigs: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.Lymphokines: Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.Glutens: Prolamins in the endosperm of SEEDS from the Triticeae tribe which includes species of WHEAT; BARLEY; and RYE.Ascitic Fluid: The serous fluid of ASCITES, the accumulation of fluids in the PERITONEAL CAVITY.BCG Vaccine: An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.Tuberculin Test: One of several skin tests to determine past or present tuberculosis infection. A purified protein derivative of the tubercle bacilli, called tuberculin, is introduced into the skin by scratch, puncture, or interdermal injection.Leukocyte Adherence Inhibition Test: Test for cell-mediated antitumor immunity and related serum blocking factors based on the finding that leukocytes from cancer patients, but not from controls, when mixed in vitro with antigenic extracts of tumors of the same histological type, undergo a diminution in their normal adherence to glass surfaces. Sera from tumor-bearing patients block the LAI reaction of their own leukocytes or those of other patients with the same type of tumor.Dose-Response Relationship, Immunologic: A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Cell Migration Assays: Specific assays that measure the migration of cells. They are commonly used to measure the migration of immune cells in response to stimuli and the inhibition of immune cell migration by immunosuppressive factors.Myelin Basic Protein: An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.Lymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.Celiac Disease: A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.Cell Adhesion: Adherence of cells to surfaces or to other cells.FucoseAntigens, Fungal: Substances of fungal origin that have antigenic activity.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Methods: A series of steps taken in order to conduct research.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Cell Line, Tumor: A cell line derived from cultured tumor cells.Spleen: An encapsulated lymphatic organ through which venous blood filters.Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.Chemotaxis: The movement of cells or organisms toward or away from a substance in response to its concentration gradient.Phytohemagglutinins: Mucoproteins isolated from the kidney bean (Phaseolus vulgaris); some of them are mitogenic to lymphocytes, others agglutinate all or certain types of erythrocytes or lymphocytes. They are used mainly in the study of immune mechanisms and in cell culture.Animal Migration: Periodic movements of animals in response to seasonal changes or reproductive instinct. Hormonal changes are the trigger in at least some animals. Most migrations are made for reasons of climatic change, feeding, or breeding.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Protein-Energy Malnutrition: The lack of sufficient energy or protein to meet the body's metabolic demands, as a result of either an inadequate dietary intake of protein, intake of poor quality dietary protein, increased demands due to disease, or increased nutrient losses.PTEN Phosphohydrolase: A lipid phosphatase that acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.Phosphoric Monoester Hydrolases: A group of hydrolases which catalyze the hydrolysis of monophosphoric esters with the production of one mole of orthophosphate. EC 3.1.3.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Tumor Suppressor Proteins: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.Green Fluorescent Proteins: Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.

Hypersensitivity pneumonitis: experimental production in calves with antigens of Micropolyspora faeni. (1/850)

Pneumonitis was induced in calves by exposure to aerosols of Micropolyspora faeni with or without prior sensitization of the animals by subcutaneous injection of antigen. The pneumonitis primarily involved centrolobular areas and was characterized by alveolar septal thickening and loss of air space by cellular infiltration. Vasculitis and focal haemorrhage occurred in certain individuals and haemoproteinaceous exudate appeared within septa and alveolar lumina. The pneumonitis was compared with human farmer's lung, pneumonitis of housed cattle and other experimental hypersensitivity pneumonitides.  (+info)

Lymphocyte proliferation inhibitory factor (PIF) in alcoholic liver disease. (2/850)

Lymphocyte proliferation inhibitory factor (PIF) was determined in the supernatants of PHA-stimulated lymphocytes from patients with alcoholic liver disease. PIF was assayed by determining inhibition of DNA synthesis in WI-38 human lung fibroblasts. A two-fold greater inhibition in thymidine incorporation into DNA by lung fibroblasts was observed in supernatants of PHA stimulated lymphocytes from patients with alcoholic hepatitis or active Laennec's cirrhosis as compared with that found in control subjects or patients with fatty liver. It is suggested that decreased liver cell regeneration seen in some patients with alcoholic hepatitis may be due to increased elaboration of PIF.  (+info)

Macrophage electrophoretic mobility (MEM) with myelin basic protein. (3/850)

Lymphocytes from a total of 161 subjects, including normal controls and patients with malignant and non-malignant conditions, have been investigated for their response to myelin basic protein, using the macrophage electrophoretic mobility (MEM) test. It has been confirmed that there was a high level of association between clinically evident cancer and a positive response. Lymphocytes from 24/25 patients with non-malignant inflammatory and ischaemic diseases also gave positive responses. In 46 patients with breast lumps studied before mastectomy or biopsy, the test was positive in 15/19 cases which proved to be malignant and in 5/27 which proved benign on histological examination. In its present form the test is not sufficiently reliable for the diagnosis of early cancer. Our results suggest that tissue necrosis in malignant and non-malignant conditions may be one of the factors resulting in sensitization to antigenic determinants present in preparations of myelin basic protein. Despite its technical difficulties, the test may provide a means of examing some aspects of immune recall not readily revealed by other test systems.  (+info)

Leucocyte migration inhibition with inner and outer membranes of mitochondria and insoluble hepatocyte surface membranes prepared from rat liver in patients with chronic hepatitis and cirrhosis. (4/850)

Patients with chronic liver disease were tested for delayed hypersensitivity to the outer and the inner membranes of mitochondria (OMM and IMM) and the insoluble hepatocyte-surface membranes (IHSM), prepared from rat livers, by means of leucocyte migration inhibition technique. Positive reaction to OMM was found in 37% of patients with chronic persistent hepatitis and 35% of those with chronic active hepatitis and 43% of those with liver cirrhosis (P less than 0-05). That to IMM was 55%, 43% and 36% (P less than 0-05) and to IHSM was 37%, 47% and 45% respectively (P less than 0-05). IHSM was found to contain liver-specific components and patients with positive response to IHSM did not reveal at all a positive reaction to rat renal cell-surface membranes. The incidence of positive response to IHSM was significantly higher (54-2%) in patients with the present or previous infection with HBAg than in HBAg-non-infected patients (21-4%) (P less than 0-05). And there seemed to be a good correlation between a degree of cellular response to purified HBsAg and that to IHSM in these HBAg-infected patients. No correlation, however, was found between that to purified HBsAg and that to OMM or IMM in the same patients. This suggested that the cellular response to either HBsAg or IHSM, both related closely, may play a role in the perpetuation of chronic liver disease.  (+info)

Cell-mediated immune responses in owl monkeys (Aotus trivirgatus) with trachoma to soluble antigens of Chlamydia trachomatis. (5/850)

The first temporal study of the cell-mediated immune responses (CMI) following ocular infections with Chlamydia trachomatis is presented. We examined the CMI of owl monkeys infected with trachoma to soluble antigens of C. trachomatis by leucocyte migration inhibition (LIF) and delayed hypersensitivity skin testing. Delayed hypersensitivity of a systemic nature developed after a local eye infection in owl monkeys; clearance of inclusions from conjunctival cells coincided with the onset of this response. The association of eye secretion and circulating antibodies with recovery from primary infection was not so striking. Both cellular and humoral immune responses persisted for at least 2 months, at which time all test animals were completely resistant to re-infection. The elicitation of cell-mediated immune reactions with solubilized chlamydial antigens may permit the isolation of specific antigens involved in the generation of protective immunity in the owl monkey model.  (+info)

Acquired cellular resistance, delayed hypersensitivity, and altered macrophage migration in Listeria monocytogenes-infected guinea pigs. (6/850)

A Listeria monocytogenes infection in guinea pigs was used to study the interrelationship between antigen-induced macrophage migration inhibition, delayed-type hypersensitivity, and acquired cellular resistance. Early after infection (at 2 and 7 days), very significant enhancement of macrophage migration was observed. Migration inhibition was detected beginning on day 14 and was uniformly observed only on day 21 of the infection, after which a shift again to enhancement was seen. The early detection (by day 2) of migration enhancement suggested that this assay may be more sensitive than assessment of delayed type hypersensitivity in vivo, which in this system was first detectable only on day 4. Acquired cellular resistance, as measured by enhanced survival following a high dose challenge with Listeria, was present from day 7 after infection until at least day 60. By splenic clearance studies, however, acquired cellular resistance was present only until day 14 after infection, suggesting that in this system splenic clearance was not a very reliable criterion for measuring acquired cellular resistance.  (+info)

Promotion of neutrophil chemotaxis through differential regulation of beta 1 and beta 2 integrins. (7/850)

Migration of neutrophils requires sequential adhesive and deadhesive interactions between beta 1 and beta 2 integrins and components of the extracellular matrix. Prompted by reports that describe interaction of soluble beta-glucan with the beta 2 integrin Mac-1, a role for beta-glucan in regulation of integrin-mediated migration was investigated. Neutrophil migration in response to fMLP was assessed using an agarose overlay method with slides precoated with fibronectin (Fn) +/- beta-glucan. On Fn, random migration in excess of directed migration was observed. In contrast, migration on Fn + beta-glucan was directional, with marked diminution of random migration. This conversion of random to directed migration was seen neither when Fn was supplemented with alternative polysaccharides nor when beta-glucan was applied to other components of the extracellular matrix. This effect of beta-glucan was shown to be cation dependent and to be effected by Arg-Gly-Asp-containing peptides consistent with an integrin-mediated event. mAb inhibition studies demonstrate that beta-glucan effects this shift toward directed migration through suppression of migration mediated by Mac-1 and very late Ag 5 and enhancement of very late Ag 3-mediated migration. Adhesion assays suggest that the prochemotactic influence of beta-glucan is due, in part but not entirely, to modulation of PMN adhesion to Fn. In summary, these data support a novel role for beta-glucan in regulation of beta 1- and beta 2-mediated neutrophil migration on Fn.  (+info)

Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4+ T cells. (8/850)

Because the binding of HIV-1 envelope to CD4 initiates a configurational change in glycoprotein 120 (gp120), enabling it to interact with fusion coreceptors, we investigated how this process interferes with the expression and function of CXC chemokine receptor 4 (CXCR4) in CD4+ T lymphocytes. A recombinant gp120 (MN), after preincubation with CD4+ T lymphocytes, significantly inhibited the binding and chemotaxis of the cells in response to the CXCR4 ligand stromal cell-derived factor-1alpha (SDF-1alpha), accompanied by a markedly reduced surface expression of CXCR4. gp120, but not SDF-1alpha, induced rapid tyrosine phosphorylation of src-like kinase p56lck in CD4+ T cells, whereas both gp120 and SDF-1alpha caused phosphorylation of the CXCR4. The tyrosine kinase inhibitor herbimycin A abolished the phosphorylation of p56lck and CXCR4 induced by gp120 in association with maintenance of normal expression of cell surface CXCR4 and a migratory response to SDF-1alpha. Thus, a CD4-associated signaling molecule(s) including p56lck is activated by gp120 and is required for the down-regulation of CXCR4.  (+info)

Definition of Macrophage migration inhibition test with photos and pictures, translations, sample usage, and additional links for more information.
In seven patients with chronic beryllium disease (Be) the Be lymphocyte transformation test was positive in 100%, independent of steroid therapy, and was reproducible. The Be macrophage migration inhibition test was only positive in four of seven patients (57%) not on steroids, and was not reproducible. In 72 potentially exposed healthy beryllium workers the lymphocyte transformation test was negative in all subjects. The macrophage test was positive in four of 78 and again the results were not reproducible. The workers with positive results showed no differences in age, type or duration of employment from those with negative results and showed no evidence of disease. In addition, the macrophage test was positive in two of 45 non-exposed control subjects. We also confirmed the above advantages of the lymphocyte transformation technique by using tuberculin antigen (PPD). The PPD lymphocyte transformation test gave positive results in approximately 60% of healthy beryllium workers, but the PPD ...
Semantic Scholar extracted view of Immune responsiveness to Mycobacterium leprae of healthy humans. Application of the leucocyte migration inhibition test. by Bjørn Myrvang
Yamamoto, K and Anacker, R L., "Macrophage migration inhibition studies with cells from mice vaccin- ated with cell walls of mycobacterium bovis bcg. Characterization of the experimental system." (1970). Subject Strain Bibliography 1970. 938 ...
Mowat, A M. and Ferguson, A, "Migration inhibition of lymph node lymphocytes as an assay for regional cell-mediated immunity in the intestinal lymphoid tissues of mice immunized orally with ovalbumin." (1982). Subject Strain Bibliography 1982. 3434 ...
Semantic Scholar extracted view of Influence of route and dose of antigen on the migration inhibition and plaque-forming cell responses to sheep erythrocytes in the lizard, Calotes versicolor. by Swaminathan Jayaraman et al.
Cellular hypersensitivity to an extract of human pancreas, using the leucocyte migration test (LMT), was found in twenty-nine of 101 diabetic and eight of fifty normal control subjects. However, the difference in response between diabetics and controls was confined to young insulin-dependent patients, there being no distinction between normal subjects and older diabetics treated by diet or oral hypoglycemic agents. The use of rat liver mitochondria and bovine insulin as antigens in the LMT did not induce inhibition of leucocyte migration in diabetics or controls.. ...
Migration of monocytic-phagocytic cells from guinea pigs immunized with complete Freunds adjuvant is regularly and specifically inhibited in tissue culture by 5 to 10µg/ml of PPD. Migration of leukocytes and spindle cells from such animals is inhibited by PPD less consistently and to a lesser degree.. Cutaneous hypersensitivity to PPD in these animals develops 5 days after adjuvant immunization; at this time migration of mononuclear cells from explants of lung and regional node is inhibited by addition of 10 µg/ml of PPD. Splenic cells become sensitive 2 to 3 weeks after immunization and hepatic macrophages become sensitive only several weeks later.. Cellular hypersensitivity to antigen, as measured by this technique, develops in guinea pigs infected with Histoplasma or immunized with emulsions of complete Freunds adjuvant and T4 bacteriophage, bovine γ-globulin, human γ-globulin, or picrylated guinea pig skin. The sensitivity is specific for the immunizing antigen.. Serum from immunized ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Glutathione S-transferase activity was identified in cytosol from human lymphoid-cell lines and peripheral leucocytes (polymorphonuclear-leucocyte/monocyte and small-lymphocyte fractions) and compared with human liver enzyme. The findings of closely similar elution volume in gel filtration, substrate (1-chloro-2,4-dinitrobenzene) and inhibitory (probenecid) kinetics indicate that the liver, leucocyte and lymphoid-cell transferases are closely related. The interaction of reduced glutathione and 1-chloro-2,4-dinitrobenzene was shown to occur in intact-lymphoid-cell culture, to be linear with time and quantity of cells and to have kinetics similar to those of the enzyme reaction catalysed by cytosol. ...
Definition of Macrophage migration-inhibitory factors with photos and pictures, translations, sample usage, and additional links for more information.
Cellular immunity to the hepatitis B surface antigen (HBsAg) and a liver-specific lipoprotein was studied, using the leucocyte migration test, in 38 asymptomatic blood donors found to have HBsAg in the serum. Sensitization to HBsAg was found in 26% and was related to the presence of liver damage, being detected in 47% of those with elevated serum aspartate aminotransferase but in only 13% with normal enzyme levels. The frequency of sensitization to this antigen in those with chronic persistent or chronic aggressive hepatitis on biopsy was also higher than in those with unrelated or minimal changes ...
University of Pennsylvania researchers have discovered links between skin cancer growth and the presence or absence of certain cancer-related molecules.
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... : Lakshmi Ramgopal, aka Lykanthea, this debut release of her is dated 2014, yet, I found it only a few days ago, and I am stunned - where was I in ...
Years of conversation fill a ton of digital pages, and weve kept all of it accessible to browse or copy over. Whether youre looking for reveal articles for older champions, or the first time that Rammus rolled into an "OK" thread, or anything in between, you can find it here. When youre finished, check out the boards to join in the latest League of Legends discussions. GO TO BOARDS ...
Macrophage Migration-Inhibitory Factors definition. define Macrophage Migration-Inhibitory Factors. Explain Macrophage Migration-Inhibitory Factors. What is Macrophage Migration-Inhibitory Factors? Macrophage Migration-Inhibitory Factors FAQ.
TY - JOUR. T1 - Terbinafine inhibits endothelial cell migration through suppression of the Rho-mediated pathway. AU - Ho, Pei Yin. AU - Zhong, Wen-Bin. AU - Ho, Yan Soon. AU - Lee, Wen Sen. PY - 2006/12. Y1 - 2006/12. N2 - We showed previously that terbinafine, an allylamine with fungicidal activity, could inhibit angiogenesis by suppressing the endothelial cell proliferation. In the present study, we further showed that terbinafine (0-120 μmol/L) dose dependently inhibited the adhesion and migration of human umbilical vascular endothelial cells (HUVEC). Western blot analysis showed that terbinafine decreased the levels of Ras protein and membrane-bound RhoA protein. Moreover, the terbinafine-induced migration inhibition in HUVEC was prevented by pretreatment with farnesol or geranylgeraniol. Pretreatment of HUVEC with Ras inhibitor peptide or a ROCK (a kinase associated with RhoA for transducing RhoA signaling) inhibitor, Y27632, abolished the farnesol- or geranylgeraniol-induced prevention ...
|p|One of the first cytokines described, MIF (macrophage migration inhibitory factor) was originally identified in studies of delayed hypersensitivity reactions where it was shown to inhibit macrophage migration. It is an important mediator of the innate immune response with potential roles in the pathophysiology of inflammatory, autoimmune, and neoplastic disorders. The human MIF gene encodes a 115 amino acid, 12.5 kDa secreted protein. Crystallographic studies suggest that MIF exists as a homotrimer, although some reports show that it may exist as a dimer or monomer as well. Although MIF exhibits no homology with other known cytokines, it shares structural homology with several bacterial enzymes. It has been speculated that MIF is an inflammatory mediator possibly associated with rheumatoid arthritis (RA) severity.|/p|
HLDA WorkshopHLDA VI-WS Code M MA58Quantity100 testsVolume0.4ImmunogenPermanent human cell line derived from peripheral leucocytes of a patient suf...
By Cindy Bontrager. The 2017 space migration project is underway to reallocate spaces vacated as a result of the 2016 space migration project. The space migration process allows the university to make strategic, transparent space changes that provide long-term benefits to campus. This phase includes space in Anderson, Fairchild, Holton, Leasure and Seaton halls, as well as Hale Library and Unger Complex - the former old Foundation building. Additional information regarding the available space as well as a schedule of building tours and proposal guidelines is available on the space migration website.. The process for submitting and reviewing space migration proposals will follow a similar format as the previous projects. Concept proposals must be approved and submitted by a dean or vice president by Dec. 16. Final space migration outcomes are expected to be announced by April 17, 2017. The general project timeline and working group members can be found on the space migration website. Other ...
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Snáď ani najortodoxnejší fanúšik HammerFall neočakáva od svojich obľúbencov nič revolučné, či dokonca evolučné. Kapela doteraz nikdy neuhla a stále priniesla to čo sa od nich očakávalo, viac či menej slušnú porciu melodického heavy/power metalu so zborovými chorálmi, […]. ...
Methods The migratory ability of peripheral neutrophils from healthy donors (HD) and different tumour cell lines (myeloid leukaemia HL60 cells and human pancreatic adenocarcinoma COLO357 cells) was analysed in response to N-Formylmethionyl-leucyl-phenylalanine (FMLP) or Protease-activated receptor 2 (Par-2) agonist. Because it has been shown before [2], IgGs from HD and SSc patients were used as additional stimulus for migration. Neutrophils and HL60 cells were preincubated (1h) with sitaxentan or ambrisentan, respectively, before being tested for migration (1h) using the Transwell assay. COLO357 cells were incubated (48h) in the presence of sitaxentan and migration was tested in the Oris Pro Cell assay. Migration was analysed by automatic cell counting or digital photo analysis and a migration index was calculated. ...
Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, is considered an attractive therapeutic target in multiple inflammatory and autoimmune disorders. In addition to its known biologic activities, MIF can also function as a tautomerase. Several small molecules have been reported to be effective inhibitors of MIF tautomerase activity in vitro. Herein we employed a robust activity-based assay to identify different classes of novel inhibitors of the catalytic and biological activities of MIF. Several novel chemical classes of inhibitors of the catalytic activity of MIF with IC(50) values in the range of 0.2-15.5 microm were identified and validated. The interaction site and mechanism of action of these inhibitors were defined using structure-activity studies and a battery of biochemical and biophysical methods. MIF inhibitors emerging from these studies could be divided into three categories based on their mechanism of action: 1) molecules that covalently modify the catalytic site at
Peptides , Prion Protein (PrP) Fragments , PrP (106-126); This peptide increases membrane microviscosity, intracellular Ca2+ concentration and cell migration in circulating leucocytes, and oxygen production in monocytes and neutrophils. It also induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell lines. PrP (106 126) stimulates leucocyte migration in a dose-dependent manner.; KTNMKHMAGAAAAGAVVGGLG; H-Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly-OH
We are investigating the role of DNA repair in prevention of cancer and in human development. We perform clinical, molecular, and translational investigations of two rare genetic disorders with defective DNA repair: xeroderma pigmentosum (XP) with clinical and cellular hypersensitivity to ultraviolet radiation and a 10,000-fold increased risk of skin cancer and
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Migration is a natural human phenomenon, but not one that organisations in the built environment are that focused on. City planners can anticipate the radical societal change generated by migration, in order to help cities, their populations and industries to prepare.
sundoc Migration; Titel: Untersuchungen zum Organika - Abbaupotiential aquatischer Hyphomyceten, Verfasser: Augustin, Torsten, 2003 ; Halle, Saale : Universitäts- und Landesbibliothek
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PubMedID: 23536817 | Macrophage migration inhibitory factor inhibition is deleterious for high-fat diet-induced cardiac dysfunction. | PloS one | 1/1/2013
Bay-Richter et al. Journal of Neuroinflammation (2015) 12:163 DOI /s JOURNAL OF NEUROINFLAMMATION RESEARCH Behavioural and neurobiological consequences of macrophage migration inhibitory
Blocking of monocyte migration induced by supernatant of RA SCL stimulated with TNF-α. Monocyte migration induced by supernatants of RA SCLs (RA6/1 and RA8/3)
1MFI: Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition.
1MFI: Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition.
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Subject: RE: DATAFILE?? The best way to find out is to try it. You will probably find that it depends. If you use a LMT and do uniform extents then it will do it by concatenation. (fill up the first file then move on to the 2nd etc.). If you create an LMT and do automatic extents then it is different. It does it by striping. The first extent goes in the first file, the 2nd in the 2nd file... You can see this by setting up a small test. Jim -----Original Message ...
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sundoc Migration; Titel: Immunhistochemische Untersuchungen apoptose- und proliferationsassoziierter Proteine beim klarzelligen Nierenzellkarzinom in Bezug auf klinisch-pathologische [...], Verfasser: Wüster, Mirja, 2004 ; Halle, Saale : Universitäts- und Landesbibliothek
transfer factor - MedHelps transfer factor Center for Information, Symptoms, Resources, Treatments and Tools for transfer factor. Find transfer factor information, treatments for transfer factor and transfer factor symptoms.
Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6-p38 and MEK7-JNK Pathways. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
We seek to understand the mechanisms by which host immunity converts from a protective response to one producing disease and tissue pathology. A main focus of our efforts is on the cytokine, MIF, which we cloned from the pituitary gland and discovered to counter-regulate the immunosuppressive actions of glucocorticoids. MIF production is tightly linked to the expression of many autoimmune and inflammatory diseases, and anti-MIF strategies are effective in reducing immunopathology in many experimental models of disease.An important goal for us is to elucidate the emergence of steroid resistance, aclinical problem that restricts the effective treatment of autoimmune diseases such as rheumatoid arthritis.. Our laboratory investigations encompass the biochemical, biological, andgenetic characterization of MIF, and we remain focused on understanding MIFs role in physiology and pathology. We have uncovered a unique action for MIF in sustaining inflammatory signal transduction, a pathway that impacts ...
We seek to understand the mechanisms by which host immunity converts from a protective response to one producing disease and tissue pathology. A main focus of our efforts is on the cytokine, MIF, which we cloned from the pituitary gland and discovered to counter-regulate the immunosuppressive actions of glucocorticoids. MIF production is tightly linked to the expression of many autoimmune and inflammatory diseases, and anti-MIF strategies are effective in reducing immunopathology in many experimental models of disease.An important goal for us is to elucidate the emergence of steroid resistance, aclinical problem that restricts the effective treatment of autoimmune diseases such as rheumatoid arthritis.. Our laboratory investigations encompass the biochemical, biological, andgenetic characterization of MIF, and we remain focused on understanding MIFs role in physiology and pathology. We have uncovered a unique action for MIF in sustaining inflammatory signal transduction, a pathway that impacts ...
We seek to understand the mechanisms by which host immunity converts from a protective response to one producing disease and tissue pathology. A main focus of our efforts is on the cytokine, MIF, which we cloned from the pituitary gland and discovered to counter-regulate the immunosuppressive actions of glucocorticoids. MIF production is tightly linked to the expression of many autoimmune and inflammatory diseases, and anti-MIF strategies are effective in reducing immunopathology in many experimental models of disease.An important goal for us is to elucidate the emergence of steroid resistance, aclinical problem that restricts the effective treatment of autoimmune diseases such as rheumatoid arthritis.. Our laboratory investigations encompass the biochemical, biological, andgenetic characterization of MIF, and we remain focused on understanding MIFs role in physiology and pathology. We have uncovered a unique action for MIF in sustaining inflammatory signal transduction, a pathway that impacts ...
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Explain the Asian Migration Hypothesis in detail. According to the theory, how did natives gradually spread over the continent in subsequent.
The ability of macrophages to migrate is critical for a proper immune response. During an innate immune response, macrophages migrate to sites of infection or inflammation where they clear pathogens through phagocytosis and activate an adaptive immune response by releasing cytokines and acting as antigen-presenting cells. Unfortunately, improper regulation of macrophage migration is associated with a variety of dieases including cancer, atherosclerosis, wound-healing, and rheumatoid arthritis. In this thesis, engineered substrates were used to study the chemical and physical mechanisms of macrophage migration. We first used microcontact printing to generate surfaces specifically functionalized with fibronectin and functionally blocked against cell adhesion to study the migration of RAW/LR5 murine macrophages. Using these surfaces we found that macrophage migration is biphasic with respect to increasing surface ligand or soluble chemokine concentration, and that RAW/LR5 migration is dependent on PI3K and
Elevated serum macrophage migration inhibitory factor (MIF) is associated with severe sepsis, but it is not clear whether bacteria stimulate synthesis of MIF by blood leukocytes directly or via induction of TNF. Here we assess production of MIF mRNA and protein by blood leukocytes from healthy human subjects (n = 28) following exposure to bacteria commonly associated with sepsis (Escherichia coli and Streptococcus pneumoniae). Bacteria did not increase levels of MIF mRNA or secreted protein. CD14 + monocytes were the main cell type producing MIF before and after stimulation. Exposure of leukocytes to TNF did not induce MIF. Hence elevated levels of serum MIF observed in sepsis may not reflect MIF produced by blood leukocytes stimulated directly by bacteria or TNF.. ...
... , Authors: Jan-Philipp Bach, Michael Bacher, Richard Dodel. Published in: Atlas Genet Cytogenet Oncol Haematol.
Effect of interferon Tau on the secretion of E-cadherin and macrophage migration inhibitory factor from bovine endometrial epithelial ...
Leukocyte migration is the hallmark of inflammation in vivo, and αMβ2 and Fg have been shown to contribute to leukocyte migration in multiple systems (23)(24). This study has used αMβ2 transfectants and selected mutants to dissect the molecular requirements for αMβ2-mediated cell migration to Fg and its derivatives. The major conclusions of our study are the following. (a) Fg supports a chemotactic cell migration mediated by αMβ2. This response is dependent on Fg concentration and occurs at low (1-50 μg/ml) Fg levels. (b) The αM I domain is necessary but not sufficient to support cell migration to Fg. In contrast to cell adhesion to Fg, efficient migration requires the β2 subunit. (c) The P1 and P2 peptides, as well as the D100 fragment, support cell migration. Thus, the same Fg derivatives that mediate αMβ2-dependent cell adhesion also support cell migration. (d) The P2 peptide stimulates αMβ2-mediated cell migration to Fg and the P1 peptide, in a manner similar to other αMβ2 ...
Abstract Delayed hypersensitivity phenomena in cutaneous leishmaniasis of the guinea pig, caused by Leishmania enriettii, were investigated with an antigen prepared from promastigotes grown in culture. Cutaneous delayed-type hypersensitivity was shown to persist for several months after resolution of lesions. Two in vitro correlates of delayed hypersensitivity, blastoid transformation of peripheral blood lymphocytes and the inhibition of migration of peritoneal macrophages, were also positive. Macrophage inhibition persisted several months after resolution. These results suggest that immunity to this form of leishmaniasis is cell-mediated.
The ability of cancer cells to migrate through a complex three-dimensional (3D) environment is a hallmark event of cancer metastasis. Therefore, an in vitro migration assay to evaluate cancer cell migration in a 3D setting is valuable to examine cancer progression. Here, we describe such a simple migration assay in a 3D collagen-fibronectin gel for observing cell morphology and comparing the migration abilities of cancer cells. We describe below how to prepare the collagen-fibronectin gel castings, how to set up time-lapse recording, how to draw single-cell trajectories from movies and extract key parameters that characterize cell motility, such as cell speed, directionality, mean square displacement, and directional persistence. In our set-up, cells are sandwiched in a single plane between two collagen-fibronectin gels. This trick facilitates the analysis of cell tracks, which are for the most part 2D, at least in the beginning, but in a 3D environment. This protocol has been previously published in
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PAA698Hu02, Polyclonal Antibody to Macrophage Migration Inhibitory Factor (MIF), GIF; GLIF; MMIF; Glycosylation-Inhibiting Factor; L-dopachrome isomerase; L-dopachrome tautomerase; Phenylpyruvate tautomerase | Products for research use only!
PubMed journal article Macrophage migration inhibitory factor elicits an angiogenic phenotype in human ectopic endometrial cells and triggers the production of major angiogenic factors via CD44, CD74, and MAPK signaling pathway were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
1. Grossmann M, Schmidramsl H. An extract of Petasites hybridus is effective in the prophylaxis of migraine. Int J Clin Pharmacol Ther. 2000;38:430-435. 2. Carle R. Plant-based antiphlogistics and spasmolytics [translated from German]. Z Phytother. 1988;9:67-76 3. Scheidegger C, Dahinden C, Wiesmann U. Effects of extracts and of individual components from Petasites on prostaglandin synthesis in cultured skin fibroblasts and on leucotriene synthesis in isolated human peripheral leucocytes. Pharm Acta Helv. 1998;72:376-378. 4. Reglin F. Butterbur root-a pain reliever with wide-range application possibilities. Praxis-Telegram. 1998;1:13-14. 5. Gruenwald J, Brendler T, Jaenicke C, eds. PDR for Herbal Medicines. Montvale, NJ: Medical Economics; 1998: 1020-1022. 6. Carle R. Plant-based antiphlogistics and spasmolytics [translated from German]. Z Phytother. 1988;9:67-76. 7. Ziolo G, Samochowiec L. Study on clinical properties and mechanisms of action of Petasites in bronchial asthma and chronic ...
David Bruneau, LMT is a Massage Therapist at Laplante Muscular therapy 1001 Providence Rd, Whitinsville, MA 01588. Wellness.com provides reviews, contact information, driving directions and the phone number for David Bruneau, LMT in Whitinsville, MA.
Immunology lecture on chemokines, chemokine receptor profiles, kinin and clotting system, fibrinolytic system, neutrophils, acute and chronic inflammation and NSAIDs.
LMT calibration certificate for illuminance respositivity, traceable to PTB calibrated standard, relative expanded measurement uncertainty incl. the uncertainty of the Standard employed 0.8 ...
Definition of migration of leukocytes in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is migration of leukocytes? Meaning of migration of leukocytes as a finance term. What does migration of leukocytes mean in finance?
Shan Z.X., Lin Q.X., Deng C.Y., Tan H.H., Kuang S.J., Xiao D.Z., Zhu J.N., Fu Y.H., Yu X.Y. [Identification of the interactions between the truncated fragments of macrophage migration inhibitory factor and CD74 using a yeast two-hybrid system] (Chinese) // Nan Fang Yi Ke da Xue Xue Bao = Journal of Southern Medical University. - 2009. - Декабрь (т. 29, № 12). - С. 2383-2386. - PMID 20034881. ...
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Thank you to the LMI puzzle community for turning up (especially after my last contest proved so long and difficult). There were difficult puzzles in this set as well but I was delighted to see so many different puzzles receive your accolades for favourite puzzle. Hopefully, not just the best of a bad bunch! My personal favourite was the second Thropki, so I couldnt resist including two of those. I was surprised to find that the Outside Sums was so popular. I know that it didnt require too many pencil marks, so maybe that was the reason ...
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Gas migration can be the result of slow static gel strength development, downhole volume losses or higher then expected reservior pressure. Operators can predict the potential for gas migration and use one or a combination of available treatments to help prevent gas flow.
1 Answer - Posted in: autoimmune disorders, side effect - Answer: You should contact the manufacturers directly. I could not not find any ...
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This section provides information about the how to set up a migration job, configure the migration parameters, and perform migration. It also provides information about generating migration reports:. ...
A stalagmometer is a device that has a capillary tube with a wide, bulbous middle section and a narrow bottom that allow a liquid...
TY - JOUR. T1 - Role of macrophage migration inhibitory factor in ovalbumin-induced airway inflammation in rats. AU - Kobayashi, M.. AU - Nasuhara, Y.. AU - Kamachi, A.. AU - Tanino, Y.. AU - Betsuyaku, Tomoko. AU - Yamaguchi, E.. AU - Nishihira, J.. AU - Nishimura, M.. PY - 2006/4. Y1 - 2006/4. N2 - Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that reportedly counteracts the anti-inflammatory effect of endogenous glucocorticoids. There have only been a few reports that demonstrate a potential link between MIF and bronchial asthma. In an attempt to further clarify the precise role of MIF in asthma, the present authors examined the effect of anti-MIF antibody (Ab) on airway inflammation and airway hyperresponsiveness in an ovalbumin-immunised rat asthma model. Actively immunised Brown Norway rats received ovalbumin inhalation with or without treatment of anti-MIF Ab. The levels of MIF in bronchoalveolar lavage fluid were significantly elevated after the ovalbumin ...
The effect of specific antigen on the development of physical interactions between lymph node lymphocytes (LNL) obtained from animals which had been immunized to that antigen and macrophages was examined. We found that the presence of antigen, either limited to the macrophage () or free in the medium, profoundly increased the degree of ) or free in the medium, profoundly increased the degree of Mphi-LNL interaction observed. This enhanced interaction was dependent on the coincidence in the cultures of Mphi bearing antigen and LNL from animals specifically immunized to that antigen. Although antigen-independent interactions developed equally well between syngeneic and allogeneic combinations of lymphocytes and macrophages, antigen mediated interactions required that macrophages and lymphocytes be syngeneic. Prolongation of antigen-mediated Mphi-LNL interactions resulted in the induction of LNL DNA synthesis, initially involving those lymphocytes physically associated with antigen-bearing Mphi. ...
The main objective of this study was to elucidate the possibilities to use wheat gluten (WG) as a binder for particleboards, as well as soy protein isolate (SPI). The focus was on the effect of the adhesive formulation and the processing conditions, while the press parameters were kept constant. Some aspects of the dispersion and the preparation of the dispersions that were investigated are: the dispersing agent (sodium hydroxide 0.1 M or citric acid 0.05 M), the time (1, 3 or 5h) to prepare the dispersion, the temperature (room temperature, 50 or 80°C) during the preparation of the dispersions and the effect of storing (1, 2.5 or 4 days) the dispersions before application. Additionally, utilization of cross-linker polyamidoamine-epichlorohydrin (PAAE) and trimethylolpropane triacetoacetate (AATMP) were evaluated. Furthermore, the utilization of green particles versus dried particles was examined. The concentration (12, 16, 20 or 24%) of WG dispersion and the process for applying it to the ...
Transfer factors are essentially small immune messenger molecules that are produced by all higher organisms. They are an ancient part of the immune system and represent "an archaic dialect in the language of cells." Transfer factors were originally described as immune molecules that are derived from blood or spleen cells that cause antigen-specific cell-mediated immunity, primarily delayed hypersensitivity and the production of lymphokines, as well as binding to the antigens themselves. They have a molecular weight of approximately 5000 Daltons and are composed entirely of amino acids. Transfer factors were discovered by Henry Sherwood Lawrence in 1954. A second use of the term transfer factor applies to a likely different entity derived from cow colostrum or chicken egg yolk which is marketed as an oral dietary supplement under the same name citing claims of benefit to the immune system. In 1942, Merrill Chase discovered that cells taken from the peritoneum of Guinea pigs that had been ...
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MIF Protein, 0.1 mg. The cytokine Macrophage migration inhibitory factor (MIF) has been identified to be secreted by the pituitary gland and the monocyte/macrophage and to play an important role in endotoxic shock.
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Woo hoo Bonnie! Im so very happy for you! I know youve been working on this a LONG time - or at least it seems that way. But I never doubted your for a minute. Everything you choose to do you do very well - and usually excel. If I were in your neck of the woods Id pop over for a massage in a heartbeat. Hmmmm . . . how to you feel about traveling? :-) ...
Claranets tried and tested methodology has helped leading European organizations intelligently migrate to the cloud. Claranet has a wealth of experience delivering large, successful migration projects, where the business benefits are clear. Claranets comprehensive migration framework considers how each workload should be treated to gain the full benefits of moving to the cloud. Claranets dedicated team of site-reliability engineers are focused on building long-term, strategic relationships with our customers, and supporting them from their first engagement to the continuous improvement of their services ...
0. Fish Migration Monitoring (stacomiR) - stacomiR stands for migratory control stations. It enables to read informations in a database dedicated to the monitoring of fish migrations.It allows to build overviews of fish migrations and create charts with data ...
... monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration". Cardiovascular ... In skin, Langerhans cells strongly express ALOX5. Fibroblasts, smooth muscle cells and endothelial cells express low levels of ... mast cells, dendritic cells, and B-lymphocytes express ALOX5. Platelets, T cells, and erythrocytes are ALOX5-negative. ... and the pharmacological inhibition of ALOX5 in these human cell lines causes them to die by entering apoptosis.[18][19][20][21] ...
inhibit cell migration of endothelial cells. ramucirumab. inhibition of VEGFR2[33]. ... inhibit cell proliferation of endothelial cells. thrombospondin. inhibit cell migration, cell proliferation, cell adhesion and ... inhibit cell proliferation and induce apoptosis of endothelial cells. endostatin. inhibit cell migration, cell proliferation ... inhibit cell proliferation and induce apoptosis of endothelial cells. endostatin. inhibit cell migration, cell proliferation ...
"Inhibition of SNARE-mediated membrane traffic impairs cell migration". Experimental Cell Research. 305 (1): 63-73. doi:10.1016/ ... Bves demonstrates dynamic localization, dependent upon cell-cell junction formation. Prior to cell-cell contact, Bves is ... Disruption of Bves results in decreased cell speed and increased cell roundness, which are cell processes modulated by the Rho ... "Tetanus neurotoxin-mediated cleavage of cellubrevin impairs epithelial cell migration and integrin-dependent cell adhesion". ...
Further, this process promotes epithelial cell migration, proliferation and apoptosis. For menstruation, it promotes the ... and only hematopoietic cells remained after that time. Tissue remodeling In order for MMPs to escape TIMP inhibition, active ... In human glioma cell lines and human squamous cell carcinoma cell line II-4, TGF-β stimulates the expression of MMP7 mRNA and ... MMP7 cleaves cell surface proteins, promotes adhesion of cancer cells, and increases the potential of tumor metastasis. Higashi ...
"Inhibition of Cell Migration and Cell Division Correlate with Distinct Effects of Microtubule Inhibiting Drugs". Journal of ... Journal of Cell Science. 20 (1): 79-89. PMID 942954. Archived (PDF) from the original on 2014-01-13.. ... Adverse effects of vinblastine include hair loss, loss of white blood cells and blood platelets, gastrointestinal problems, ... non-small cell lung cancer, bladder cancer, brain cancer, melanoma, and testicular cancer.[1] It is given by injection into a ...
... a molecule which can stimulate cell migration. The HA produced by HAS also has been suggested to protect the cancer cell from ... Inhibition of hyaluronan synthases decreases matrix metalloproteinase-7 (MMP-7) expression and activity. Surgery. 2009;145:32- ... Cell Adhesion and Migration. 2008;2:202-207 Jiang D, et al. Regulation of lung injury and repair by Toll-like receptors and ... This role of HA has been shown in other cell types, but has not yet been researched in cancer cells. The HA produced by HAS up- ...
Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by ...
Thus, the inhibition of this interaction through APG101 reduces tumor cell growth and migration. An article published in the ... MDS is a disease in which the bone marrow does not make enough healthy blood cells, which leads to blood cytopenias, especially ... Mar 2008). "Yes and PI3K bind CD95 to signal invasion of glioblastoma". Cancer Cell. 13 (3): 235-48. doi:10.1016/j.ccr.2008.02. ... the binding of the CD95 ligand to its cognate receptor stimulates the invasive growth of glioblastoma cells. ...
This interaction inhibits the activation of MEK and ERK and even cell migration. In cancer tissues, where ARHI is not expressed ... ARHI influences also the cell cycle, specifically ARHI's strong inhibition of the cyclin D1 promoter. Cyclin D1 is an essential ... "The tumour suppressor DiRas3 interacts with C-RAF and downregulates MEK activity to restrict cell migration". Biology of the ... and its regulation by ARHI is critical in maintaining healthy cells. This is the mechanism by which ARHI inhibits cell growth ...
Yang, Hailing; Ganguly, Anutosh; Cabral, Fernando (2010). "Inhibition of Cell Migration and Cell Division Correlates with ... Colcemid inhibition of microtubules causes aneuploidy in mitotic cells where the microtubules fall apart or are suppressed ... Lower concentrations affect microtubule dynamics and cell migration. Colcemid is used primarily for scientific research in ... thus arresting cells in metaphase and allowing cell harvest and karyotyping to be performed. Colcemid is a microtubule- ...
Yang, Hailing; Ganguly, Anutosh; Cabral, Fernando (2010). "Inhibition of cell migration and cell division correlate with ... thus arresting cells in metaphase and allowing cell harvest and karyotyping to be performed. During cell division, demecolcine ... Lower concentration affects microtubule dynamics and cell migration. Br Med J., 1965, 1, 495 - 496 Reprod Nutr Dev. 2006 Mar- ... Medically, demecolcine has been used to improve the results of cancer radiotherapy by synchronising tumour cells at metaphase, ...
... and induction of cell migration.[6] Through their inhibition of adenylyl cyclase via their Gi/Goα subunits, CB2 receptor ... These receptors were primarily localized on immune cells such as monocytes, macrophages, B-cells, and T-cells.[6][10][22][23][ ... "2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral ... Possible candidates include mast cells, known to facilitate the inflammatory response. Cannabinoid mediated inhibition of these ...
GABA regulates the proliferation of neural progenitor cells[12][13] the migration[14] and differentiation[15][16] the ... Shunting inhibition has no direct effect on the membrane potential of the cell; however, it reduces the effect of any ... GABA can promote the replication and survival of β-cells[23][24][25] and also promote the conversion of α-cells to β-cells, ... "Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis". Cell. 168 (1-2): 73-85.e11. doi:10.1016/j ...
"MiR-340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met". Cancer. 117 (13): 2842 ... "Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity". Brain. 134 (12): 3578- ...
... caused the inhibition of recombinant interleukin-8 (IL-8) induced migration of the inflammatory cells. Two other pro- ... Gastric parietal cells are rich in mitochondria which provide energy in the form of ATP for cells by oxidative phosphorylation ... They also inhibit mast cell activation, and leukocyte and platelet adherence to the vascular endothelium. Thus, continuous ... In addition to inhibition of pro-inflammatory mediators, troxipide directly acts on the enzymes such as xanthine oxidase and ...
"Sesquiterpene Lactone Suppresses Vascular Smooth Muscle Cell Proliferation and Migration via Inhibition of Cell Cycle ...
Yang, H.; Ganguly, A.; Cabral, F. (2010). "Inhibition of Cell Migration and Cell Division Correlate with Distinct Effects of ... Severe side effects include low blood cell counts and shortness of breath. It should not be given to people who have a current ... Vinblastine works by blocking cell division. Vinblastine was isolated in 1958. It is on the World Health Organization's List of ... Vinblastine treatment causes M phase specific cell cycle arrest by disrupting microtubule assembly and proper formation of the ...
Inhibition of NFAT5 in embryonic fibroblasts resulted in cell cycle arrest. Although NFAT5 has been found to be important in ... Additionally, NFAT5 plays a role in integrin-induced cell migration. Overexpression of NFAT5 enhanced movement. To increase ... It has been shown that when NFAT5 is inhibited in renal and immune cells, these cells become significantly more susceptible to ... However, an increase in intracellular ionic concentration is harmful to the cell. Cells can alternatively synthesize enzymes ...
... angiogenesis and cell migration. Homologous subfamily of ADAMTSL (ADAMTS-like) proteins, which lack enzymatic activity, has ... Most cases of thrombotic thrombocytopenic purpura arise from autoantibody-mediated inhibition of ADAMTS13. Like ADAMs, the name ... Cell Biology. 15: 981-985. PMID 20036837. Kelwick, Richard; Desanlis, Ines; Wheeler, Grant N; Edwards, Dylan R (2015-05-30). " ...
... and invasion of malignant cells. Other studies suggest that crizotinib might also act via inhibition of angiogenesis in ... Crizotinib is currently thought to exert its effects through modulation of the growth, migration, ... About 4% of patients with non-small cell lung carcinoma have a chromosomal rearrangement that generates a fusion gene between ... In March 2016, the U.S. Food and Drug Administration approved crizotinib in ROS1-positive non-small cell lung cancer. ...
... migration, and invasion in glioma cell lines is antagonized by macrophage migration inhibitory factor (MIF) and can be enhanced ... Piette C., Deprez M., Roger T., Noël A., Foidart J.M., Munaut C. The dexamethasone-induced inhibition of proliferation, ... Cell : journal. - Cell Press (англ.)русск., 1982. - May (vol. 29, no. 1). - P. 61-9. - DOI:10.1016/0092-8674(82)90090-3. - PMID ... Cell : journal. - Cell Press (англ.)русск., 1993. - July (vol. 74, no. 2). - P. 257-268. - DOI:10.1016/0092-8674(93)90417-O. - ...
This can lead to the formation of stress fibers and cell migration through the inhibition of myosin light-chain phosphatase. ... 2010). "Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression ... Because of its ability to stimulate cell proliferation, aberrant LPA-signaling has been linked to cancer in numerous ways. ...
Too much inhibition leads to unregulated cell cycle progression and tumorigenesis. However, enough PTEN inhibition promotes ... one can temporarily and safely effect the PI3K/AKT pathway to influence cell migration,[26] survival[27] and proliferation.[6] ... Cells that are forced to overexpress AKT increase the amount of CREB and proliferation compared to wild type cells. These cells ... FOXO knockouts lose the ability for cells to enter a quiescent state as well as cells losing their neural stem cell character, ...
Wnt signaling functions can be divided into axis patterning, cell fate specification, cell proliferation and cell migration. In ... PDE mediates this through the inhibition of PKG, which subsequently causes the inhibition of calcium release. The binary ... Cell fate specification or cell differentiation is a process where undifferentiated cells can become a more specialized cell ... Wnt signaling also induces cell migration in later stages of development through the control of the migration behavior of ...
... and its inhibition blocked the migration of dendritic immune cells, possibly related to the outward transport of the lipid ... In multidrug-resistant cells, the MDR1 gene is frequently amplified in multidrug-resistant cells. This results in a large ... Randolph GJ (2001). "Dendritic cell migration to lymph nodes: cytokines, chemokines, and lipid mediators". Seminars in ... The higher the MDR activity is in the cell membrane, the less Calcein is accumulated in the cytoplasm. In MDR-expressing cells ...
Any changes in cytoskeletal organization and adhesion can lead to altered signaling, migration and a loss of contact inhibition ... F9 embryonal carcinoma cells are similar to the P19 cells shown in Figure 1 and normally have cell-to-cell adhesion mediated by ... A tumor cell line with defective δ-catenin, low levels of E-cadherin and poor cell-to-cell adhesion could be restored to normal ... providing the cell with a means of stable cell adhesion. However, decreases in this adhesion ability of the cell has been ...
6 JQ1 inhibits the migration and invasion of SACC cells. a The migration of ACC-LM cells and ACC-83 cells treated by JQ1 at ... In this study, we investigated the effect of BRD4 inhibition by JQ1 on cell growth, migration and invasion of SACC cells in ... 7). These results suggest that the inhibition effect of JQ1 on SACC cell migration and invasion may be due to EMT inhibition. ... JQ1 inhibits the migration and invasion of SACC cells. The effect of JQ1 on cell migration and invasion was investigated. The ...
Overexpression of PTEN inhibited cell migration, whereas antisense PTEN enhanced migration. Integrin-mediated cell spreading ... 3 cells/mm2) or sense-transfected cells (0 ± 0 cells/mm2) (Fig. 1A). The number of migrating PTEN-overexpressing cells was ... PTEN modulation of cell migration. Stable NIH 3T3 cell transfectants were induced to express PTEN or antisense PTEN in an ... PTEN inhibition of cell spreading. (A) NIH 3T3 cell transfectants expressing sense or antisense PTEN induced by ecdysone were ...
Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine ... Triptolide Inhibits Proliferation and Migration of Colon Cancer Cells by Inhibition of Cell Cycle Regulators and Cytokine ... Triptolide Inhibits Proliferation and Migration of Colon Cancer Cells by Inhibition of Cell Cycle Regulators and Cytokine ... Triptolide Inhibits Proliferation and Migration of Colon Cancer Cells by Inhibition of Cell Cycle Regulators and Cytokine ...
In vivo and in vitro inhibition of migration of metastatic melanoma cells. Maxine Emmett, Darryl Dunn, Francoise Cailler, Denis ... In vivo and in vitro inhibition of migration of metastatic melanoma cells ... In vivo and in vitro inhibition of migration of metastatic melanoma cells ... In vivo and in vitro inhibition of migration of metastatic melanoma cells ...
Abstract 722: Inhibition of Endothelial Cell Migration by Semaphorin 3C Requires Neuropilin-1 Uptake via Lipid Rafts. Arie ... Abstract 722: Inhibition of Endothelial Cell Migration by Semaphorin 3C Requires Neuropilin-1 Uptake via Lipid Rafts ... Abstract 722: Inhibition of Endothelial Cell Migration by Semaphorin 3C Requires Neuropilin-1 Uptake via Lipid Rafts ... Abstract 722: Inhibition of Endothelial Cell Migration by Semaphorin 3C Requires Neuropilin-1 Uptake via Lipid Rafts ...
Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells through the inhibitions of NF-kB and ... Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells through the inhibitions of NF-kB and ...
... and a variety of cell types (inflammatory exudate cells, tumor cells). In … ... We have compared the capillary tube assay for migration inhibition studies with our modification of the agarose microdroplet ... Correlation between agarose microdroplet and capillary tube procedures as assays for migration inhibition of target cells J ... and a variety of cell types (inflammatory exudate cells, tumor cells). In all circumstances both procedures gave quantitatively ...
... which is known to play a role in PI 3-kinase-mediated cell migration.31-34⇓⇓⇓ Because PI 3-kinase-mediated cell migration has ... which displayed little cell death. Enhanced apoptosis could also partly account for PTENs inhibition of cell migration. ... Inhibition of Vascular Smooth Muscle Cell Proliferation, Migration, and Survival by the Tumor Suppressor Protein PTEN. Jianhua ... then the cell monolayer was disrupted and cells were treated with or without PDGF (20 ng/mL). A, Migration of cells into the ...
Inhibition of ATX-mediated human MDA-MB-231 cell migration at 10 uM after 8 hrs by Cyto Fluor spectrophotometry relative to ...
SERCA Cysteine-674 Is Required for NO-Mediated Inhibition of HEK Cell Migration. After validating the HEK cell model, migration ... As in experiments in HEK cells, inhibition of VSMC migration by NO after 6 hours reached significance, and the inhibition by ... Because Ca2+ is an important second messenger for cell migration, we hypothesized that NO also inhibits cell migration through ... and NO-induced inhibition of Ca2+influx, which consequently could affect Ca2+ dependent cell functions, such as cell migration ...
... inhibiting cell migration and invasion and suppressing PI3K/AKT/m-TOR signaling pathway. PMID: 31631173 [PubMed - in process ... our results showed that Carnosic acid has the potential to inhibit cancer cell growth in A-549 lung cancer cells by activating ... Antiproliferative Activity of Carnosic Acid is Mediated via Inhibition of Cell Migration and Invasion, and Suppression of ... ïve Participants With Anti-programmed Cell Death Receptor Ligand 1 (PD-L1) Positive Advanced Non-small Cell Lung Cancer (NSCLC ...
Results: To specifically study the role of b1 integrin in cell migration, we compared cell migration of GD25 cells that are ... Abstract 397: The Interaction of Integrin beta1 to Galpha13 Mediates RhoA Inhibition and Cell Migration. Bo Shen, Brian Estevez ... Cell migration was abolished in b1-deficient cells, indicating a critical role for b1 in these assays. To study whether Ga13- ... The b1-dependent cell migration is dramatically inhibited in the ExE to alanine mutant b1-expressing cells. Importantly, a ...
Abstract 4026: Attenuation of pancreatic cancer cell migration and invasion through a targeted inhibition of the Rac GEF Vav1. ... Abstract 4026: Attenuation of pancreatic cancer cell migration and invasion through a targeted inhibition of the Rac GEF Vav1 ... Attenuation of pancreatic cancer cell migration and invasion through a targeted inhibition of the Rac GEF Vav1. [abstract]. In ... Abstract 4026: Attenuation of pancreatic cancer cell migration and invasion through a targeted inhibition of the Rac GEF Vav1 ...
FRNK Inhibition of Focal Adhesion Kinase-Dependent Signaling and Migration in Vascular Smooth Muscle Cells. Yevgeniya E. ... FRNK Inhibition of Focal Adhesion Kinase-Dependent Signaling and Migration in Vascular Smooth Muscle Cells ... FRNK Inhibition of Focal Adhesion Kinase-Dependent Signaling and Migration in Vascular Smooth Muscle Cells ... FRNK Inhibition of Focal Adhesion Kinase-Dependent Signaling and Migration in Vascular Smooth Muscle Cells ...
GLPs inhibit cell migration in LoVo cells. At 48 h, the scratch wounds were completely repaired by the migration of untreated ... Inhibition of migration and induction of apoptosis in LoVo human colon cancer cells by polysaccharides from Ganoderma lucidum. ... Cell migration serves an important role in numerous physiological processes, such as cell differentiation and proliferation (39 ... Doyle AD, Petrie RJ, Kutys ML and Yamada KM: Dimensions in cell migration. Curr Opin Cell Biol. 25:642-649. 2013. View Article ...
Inhibition of CXCL8-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay. ...
... proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human prostate-derived T24 cells ... Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder ... Upregulation of prostate-derived Ets factor by luteolin causes inhibition of cell proliferation and cell invasion in prostate ... Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human ...
Inhibition of lens epithelial cell migration by acrylic intraocular lens: New evaluation method of optic edge sharpness with ... Inhibition of lens epithelial cell migration by acrylic intraocular lens: New evaluation method of optic edge sharpness with ... H. Ogura, M. Ayaki, H. Nishihara, S. Yaguchi; Inhibition of lens epithelial cell migration by acrylic intraocular lens: New ... was associated with lens epithelial cell (LEC) migration and the formation of posterior capsule opacification (PCO) in the ...
Retraction Note to: FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells ...
Inhibition of Protein Kinase Cα Prevents Endothelial Cell Migration and Vascular Tube Formation In Vitro and Myocardial ... Inhibition of Protein Kinase Cα Prevents Endothelial Cell Migration and Vascular Tube Formation In Vitro and Myocardial ... Inhibition of Protein Kinase Cα Prevents Endothelial Cell Migration and Vascular Tube Formation In Vitro and Myocardial ... Inhibition of Protein Kinase Cα Prevents Endothelial Cell Migration and Vascular Tube Formation In Vitro and Myocardial ...
NF Kappa B Inhibitor Prevents the Inflammatory Cell Migration Through the Inhibition of MIP1a Expression in Corneal Penetrating ... NF Kappa B Inhibitor Prevents the Inflammatory Cell Migration Through the Inhibition of MIP1a Expression in Corneal Penetrating ... NF Kappa B Inhibitor Prevents the Inflammatory Cell Migration Through the Inhibition of MIP1a Expression in Corneal Penetrating ... and prevents the migration of inflammatory cells in corneal stroma and anterior chamber. ...
2008). Migratory properties of cultured olfactory ensheathing cells by single-cell migration assay. Cell Res. 18, 479-490. ... 1 implies accelerated cell migration in response to the treatment. Conversely, a ratio ,1 implies inhibition of migration, and ... Slit-2 repels the migration of olfactory ensheathing cells by triggering Ca2+-dependent cofilin activation and RhoA inhibition ... Slit-2 repels the migration of olfactory ensheathing cells by triggering Ca2+-dependent cofilin activation and RhoA inhibition ...
1055865-inhibition-of-glioblastoma-cell-proliferation--migration-and-invasion-by-the-proteasome-antagonist-carfilzomib. ... Inhibition of glioblastoma cell proliferation, migration and invasion by the proteasome antagonist carfilzomib. ...
By using adenoviral-mediated expression of inducible heme oxygenase 1 in primary vascular smooth muscle cells (vsmc) in vivo, ... Targeting of cell cycle regulatory proteins promotes inhibition of cell proliferation, and cell differentiation. Cell cycle ... Helper cell lines may be derived from human cells such as human embryonic kidney cells, muscle cells, hematopoietic cells or ... cell proliferation and migration, and platelet and immune cell adhesion resulting in inhibition of vascular lesion formation ...
About the Journal. As one of the first Open Access journals in its field, Food & Nutrition Research (FNR) offers an important forum for researchers to exchange the latest results from research on human nutrition broadly and food-related nutrition in particular. Learn more about the journals Aims & Scope. FNR is widely indexed by relevant services and databases, including PubMed Central/PubMed, Scopus, Science Citation Index, with an Impact Factor of 2.086 (2017).. ...
  • By using adenoviral-mediated expression of inducible heme oxygenase 1 in primary vascular smooth muscle cells (vsmc) in vivo, the present inventors demonstrate that in vivo expression of HO1 can be used to treat restenosis. (google.com)
  • In vivo , low concentrations of attractants would stimulate cells to begin migrating. (jneurosci.org)
  • Furthermore, we evaluated whether inhibition of N-cadherin function retarded intimal thickening by modulation of VSMC migration and success using an ex lover vivo human being saphenous vein style of intimal thickening. (healthyguide.info)
  • In contrast, phenotype-driven screens have shown a much stronger success rate, which is why we developed an in vivo assay using transgenic zebrafish with a GFP-marked migrating posterior lateral line primordium (PLLp) to identify compounds that influence collective cell migration. (biologists.org)
  • We identified 165 compounds that interfere with primordium migration without overt toxicity in vivo . (biologists.org)
  • In vivo migration of granulocytes was decreased in patients with atopic asthma and elevated levels of IgE as well as in patients with infectious asthma and elevated levels of IgG. (biomedsearch.com)
  • In vivo migration of granulocytes showed significant decreases in both asthmatic groups only during asthmatic attacks. (biomedsearch.com)
  • Contribution of the macrophage migration inhibitory factor superfamily of cytokines in the pathogenesis of preclinical and human multiple sclerosis: In silico and in vivo evidences. (nih.gov)
  • Confinement is also observed in vivo, where the optimal width is a function of the number of migrating cells in different streams of different species. (wikipedia.org)
  • A number of studies in vivo have shown that BTG2 expression is associated with the neurogenic asymmetric division in neural progenitor cells. (wikipedia.org)
  • In vivo T-cadherin was detected on the apical cell surface of the chick interstinal epithelium. (wikipedia.org)
  • Dexter observed that mesenchymal stromal cells could maintain early HSCs ex vivo, and both Lord and Gong showed that these cells localized to the endosteal margins in long bones. (wikipedia.org)
  • Normal cancer cells and Cdc42-deficient cancer cells have also been compared in vivo. (wikipedia.org)
  • Xenopus has long been an important tool for in vivo studies in molecular, cell, and developmental biology of vertebrate animals. (wikipedia.org)
  • Though the concept of stem cell niche was prevailing in vertebrates, the first characterization of stem cell niche in vivo was worked out in Drosophila germinal development. (wikipedia.org)
  • By continuous intravital imaging in mice, researchers were able to explore the structure of the stem cell niche and to obtain the fate of individual stem cells (SCs) and their progeny over time in vivo. (wikipedia.org)
  • Dock2-dependent chemotaxis has been reported in response to the chemokines CXCL12/SDF-1 in T lymphocytes, CXCL13/BLC in B lymphocytes and CCL19/ELC in thymocytes (immature lymphocytes) emigrating from the thymus as well as CCL21/SLC in ex vivo plasmacytoid dendritic cells. (wikipedia.org)
  • In vivo, egfl7 knockdown expression in hepatocellular carcinoma cells decreases the number of intra-hepatic and pulmonary metastases. (wikipedia.org)
  • A study showed that forced expression of calponin 2 in endothelial cells enhanced angiogenic cell migration in vivo and anti-sense calponin 2 RNA reduced chemotaxis of human umbilical vein endothelial cells in culture. (wikipedia.org)
  • It has been successfully used in fluorescent imaging experiments involving myosin IIA-GFP expressing live dendritic cells A water-soluble blebbistatin derivative developed in 2016, its high water solubility (~400 uM) enables in vivo research applications. (wikipedia.org)
  • We have compared the capillary tube assay for migration inhibition studies with our modification of the agarose microdroplet technique, using several sources of factors with inhibitory activity (lymphokines, bacterial factors) and a variety of cell types (inflammatory exudate cells, tumor cells). (nih.gov)
  • The proto-oncogene Vav1 is ectopically expressed in over half of human pancreatic cancers, and its expression correlates with a poor prognosis in humans and promotes survival and transformation in isolated tumor cells. (aacrjournals.org)
  • We have found that Vav1, through its GEF activity towards Rac1, also potently induces migration by pancreatic tumor cells. (aacrjournals.org)
  • Vav1-expressing tumor cells were more sensitive to azathioprine than Vav1-negative cells, supporting the premise that the inhibitory effects of azathioprine are mediated through Vav1. (aacrjournals.org)
  • Even with the expression of multiple Rho family GEFs, tumor cells that upregulate Vav1 have become dependent upon this exchange factor, implicating Vav1 as a potent node for therapeutic intervention. (aacrjournals.org)
  • These RCP-driven changes in α5β1 trafficking led to acquisition of rapid/random movement on two-dimensional substrates and to a marked increase in fibronectin-dependent migration of tumor cells into three-dimensional matrices. (rupress.org)
  • We conclude that RCP provides a scaffold that promotes the physical association and coordinate trafficking of α5β1 and EGFR1 and that this drives migration of tumor cells into three-dimensional matrices. (rupress.org)
  • Sec62 is essential for cell migration and protects tumor cells against thapsigargin-induced ER stress, which are both linked to cytosolic Ca 2+ . (biomedcentral.com)
  • We evaluated the ability of cannabidiol (CBD) to impair the migration of tumor cells stimulated by conditioned medium. (nih.gov)
  • Autophagy is an evolutionarily conserved self-defense mechanism that allows tumor cells to overcome stress during oncogenesis and after treatment with chemotherapy. (aacrjournals.org)
  • Specifically, tumor cells release various pro-angiogenic paracrine factors (including angiogenin, vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and transforming growth factor-β (TGF-β). (wikipedia.org)
  • DLC1 expression is frequently lost in tumor cells, resulting in constitutive activation of the RhoGTPases RhoA and Cdc42. (wikipedia.org)
  • CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. (wikipedia.org)
  • Studies revealed that inhibition of CLU resulted in increased effectiveness of chemotherapeutic agents to kill tumor cells. (wikipedia.org)
  • Cells were treated with TRP for 6 h prior to seeding into chambers in serum-free media and then allowed to migrate overnight (A) or for 6 h (B) toward the specified chemoattractant with the indicated dose of TRP. (nih.gov)
  • Olfactory ensheathing cells (OECs) migrate from the olfactory epithelium towards the olfactory bulb during development. (biologists.org)
  • For cells to migrate, they must form new lamellipodia, adhere to the substratum at the front of the cell, detach from the substratum at the tail of the cell, and retract their tail. (ahajournals.org)
  • The lack of cohesion and biochemical cell-cell communication in the model suggests that these factors are not strictly necessary for cells to migrate as a group. (biologists.org)
  • Indeed, one of the features of malignant cells, and one that makes cancer so difficult to treat, is their capacity to migrate invasively through the stroma to form metastases ( Sahai, 2005 ). (rupress.org)
  • When placed in the EasySep™ Magnet, labeled cells migrate to the wall of the tube. (stemcell.com)
  • Endodermal cells showing characteristic filopodia then migrate into the inner layer within the hypoblast next to the yolk syncytial layer (YSL). (biologists.org)
  • Since endodermal cells migrate separately from mesodermal cells within the hypoblast layer, the zebrafish gastrula provides a useful model system in which to study endodermal cell migration. (biologists.org)
  • Normal breast epithelial cells do not have the capacity to migrate efficiently in response to chemotactic signals. (aacrjournals.org)
  • In spinal cord injury, Schwann cells also migrate to lesion sites and assist in sustaining axons ( Blesch and Tuszynski, 2007 ). (jneurosci.org)
  • Migration can be of different types and natures: Cells can migrate alone or in groups, and these groups can adopt different shapes and organizations ( 1 ). (pnas.org)
  • In the CIL process, cells migrate away from each other by repolarizing in the new direction, so that new protrusions are formed in the front while contractions pull the back from contact. (wikipedia.org)
  • Cells often migrate in response to specific external signals, including chemical signals and mechanical signals. (wikipedia.org)
  • An understanding of the mechanism by which cells migrate may lead to the development of novel therapeutic strategies for controlling, for example, invasive tumour cells. (wikipedia.org)
  • Other eukaryotic cells are observed to migrate similarly. (wikipedia.org)
  • Cells actively sense ECM rigidity and migrate preferentially towards stiffer surfaces in a phenomenon called durotaxis. (wikipedia.org)
  • Cdc42 overexpression significantly improved the ability of cervical cancer cells to migrate, possibly due to improved pseudopodia formation. (wikipedia.org)
  • Pyramidal CA1 and CA3 precursor cells, therefore, do not have to migrate far to reach their final destination. (wikipedia.org)
  • Primary fibroblasts and peritoneal macrophages isolated from Cnn2 knockout mice migrate faster than that of wild type control cells. (wikipedia.org)
  • This public-private collaboration enabled researchers identify molecular mechanisms underlying the lack of efficiency of this drug in squamous cell carcinoma, a sub-type of non-small cell lung cancer, and the important role of smoking in this lack of effectivity. (medworm.com)
  • LncRNA MALAT1 has been proved to be involved in the development of various types of human cancers while the involvement of MALAT1 in tongue squamous cell carcinoma has not been reported. (europeanreview.org)
  • In view of this, our study aimed to investigate the functionality of MALAT1 in tongue squamous cell carcinoma. (europeanreview.org)
  • MALAT1 may serve as a target for the treatment of tongue squamous cell carcinoma. (europeanreview.org)
  • Esophageal squamous cell carcinoma (ESCC) is the predominant histological type of esophageal cancer that occurs in most Asian countries 2 . (nature.com)
  • In recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M-SCCHN), the armamentarium of systemic anti- cancer modalities continues to grow in parallel with innovations in and better integration of local approaches. (nih.gov)
  • Fyn overexpression has been studied in relation to the following cancers: prostate cancer, glioblastoma multiform, squamous cell carcinoma of the head and neck, pancreatic cancer, chronic melogenic leukemia, and melanoma. (wikipedia.org)
  • Directly inhibiting PI3K in NSCs leads to a population of cells that are purely HB9+ and differentiate at an elevated efficiency into motor neurons. (wikipedia.org)
  • Grafting these cells into different parts of rats generates motor neurons regardless of the transplanted cells' microenvironment. (wikipedia.org)
  • It is the purpose of modern research to generate neural stem cells that can proliferate but still differentiate into motor neurons. (wikipedia.org)
  • This shortened version SRGAP2C inhibits the function of the ancestral copy SRGAP2A and (1) allows faster migration of neurons by interfering with filopodia production and (2) slows the rate of synaptic maturation and increases the density of synapses in the cerebral cortex. (wikipedia.org)
  • Should neurons follow an abnormal migration during development possible cortical malformations include classical lissencephaly (as stated above) and subcortical band heterotopia with an agyria-pachygyria band spectrum. (wikipedia.org)
  • The abnormal migration of the neurons causes them to not reach their proper final destinations, which results in failure of the sulci and gyri to form. (wikipedia.org)
  • Neural progenitors that become hippocampal principal neurons (pyramidal and granular cells) arise from the ventricular zone of the lateral ventricle. (wikipedia.org)
  • The figure to the right indicates migration of pyramidal neurons forming the CA3 (orange) and CA1 (red) cell body layers. (wikipedia.org)
  • As in the cortex, it is believed that reelin plays an important role in layering of hippocampal neurons through inhibition of migration. (wikipedia.org)
  • When the neurons reach the OB they differentiate into GABAergic interneurons as they are integrated into either the granule cell layer or periglomerular layer. (wikipedia.org)
  • In multicellular organisms, chemotaxis is critical to early development (e.g., movement of sperm towards the egg during fertilization) and subsequent phases of development (e.g., migration of neurons or lymphocytes) as well as in normal function. (wikipedia.org)
  • Expression of egfl7 has also been reported in primordial germ cells and in adult ovaries and testes and in neurons. (wikipedia.org)
  • While most of the results obtained with docosahexaenoic acid and/or eicosapentaenoic acid show a decrease of tumor cell proliferation and/or aggressivity, there is some evidence that other lipids, which accumulate in breast cancer tissues, such as arachidonic acid may have opposite effects. (hindawi.com)
  • The EasySep™ Mouse T Cell Isolation Kit is designed to isolate T cells from single-cell suspensions of splenocytes or other tissues by negative selection. (stemcell.com)
  • The recruitment of bone marrow-derived mesenchymal stem cells (BMSCs) to damaged tissues and sites of inflammation is an essential step for clinical therapy. (hindawi.com)
  • Of note, in all of these preclinical and clinical studies, the engraftment of BMSCs into damaged tissues via migration to suppress immune responses or enhance tissue repair/regeneration is a crucial process for clinical therapy [ 13 ]. (hindawi.com)
  • Here, we used adhesive microstripes of varying widths to mimic the spatial confinement experienced by follower cells within epithelial tissues. (nature.com)
  • Plexin-B1 expression was analyzed in normal and benign ovarian tissues and serous ovarian tumors (both borderline and malignant) by immunohistochemical staining, as well as in four human ovarian cancer cell lines (A2780, C13*, SKOV3, and OV2008) by RT-PCR and western blot analyses. (springer.com)
  • During the development of multicellular organisms, complex cell migration events take place to organize the general body shape, tissues, and organs. (pnas.org)
  • While ARHI is constitutively expressed in normal ovarian and breast epithelial cells, it is absent in cancers found in these tissues where no expression of ARHI has been detected. (wikipedia.org)
  • It is ubiquitously expressed in many tissues and cell types. (wikipedia.org)
  • In addition, Slit-Robo signaling contributes to cell migration and the development of other tissues such as the lung, kidney, liver, muscle and breast. (wikipedia.org)
  • PTPmu is expressed in different organ tissues in the body, including the lung, heart and brain, pancreas, endothelial cells in capillaries and arteries throughout the body, and in retinal and brain cells. (wikipedia.org)
  • Proliferating reactive scar-forming astrocytes are consistently found along borders between healthy tissues and pockets of damaged tissue and inflammatory cells. (wikipedia.org)
  • Tissue repair and maintenance are important parts of the life cycle of an organism, cells and tissues must remain in homeostasis to ensure survival. (wikipedia.org)
  • Angiomotin is expressed predominantly in endothelial cells of capillaries as well as angiogenic tissues such as placenta and solid tumor. (wikipedia.org)
  • Cells, Tissues, Organs. (wikipedia.org)
  • Normal cells that stain positively for CD56 include NK cells, activated T cells, the brain and cerebellum, and neuroendocrine tissues. (wikipedia.org)
  • B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. (wikipedia.org)
  • ATM is believed to regulate double-strand break repair directly or indirectly through cell cycle checkpoint control, and inhibition or absence of ATM increases radiosensitivity ( 7 , 9 ). (aacrjournals.org)
  • In this study, we show that border cell migration requires the function of the small GTPases Rab5 and Rab11 that regulate trafficking through the early and the recycling endosome, respectively. (pnas.org)
  • In contrast, BTG1, the closest homolog to Btg2, appears to negatively regulate the proliferation of adult stem cells in the dentate gyrus and subventricular zone, maintaining in quiescence the stem cells pool and preserving it from depletion. (wikipedia.org)
  • Stem-cell niche refers to a microenvironment, within the specific anatomic location where stem cells are found, which interacts with stem cells to regulate cell fate. (wikipedia.org)
  • citation needed] A Nature Insight review defines niche as follows: "Stem-cell populations are established in 'niches' - specific anatomic locations that regulate how they participate in tissue generation, maintenance and repair. (wikipedia.org)
  • Ependymal cells actively regulate neuronal fate specification of adult neural precursors through release of Noggin. (wikipedia.org)
  • Rac isoforms regulate a multitude of processes in leukocytes and studies so far have shown that Dock2-dependent Rac activation regulates the neutrophil NADPH oxidase and is also important for chemotaxis in neutrophils, lymphocytes and plasmacytoid dendritic cells. (wikipedia.org)
  • Mesenchymal stem cells (MSCs) have been shown to affect both innate and adaptive immune response [ 1 - 3 ]. (hindawi.com)
  • It has been shown that when NFAT5 is inhibited in renal and immune cells, these cells become significantly more susceptible to osmotic stress. (wikipedia.org)
  • Filopodia are also used for movement of bacteria between cells, so as to evade the host immune system. (wikipedia.org)
  • It has also been shown that chemokines are involved in guiding immune cells to sites of axon lesions to facilitate inflammation and debris clearance as well as possibly guiding OPCs migration to lesion sites. (wikipedia.org)
  • Many human blood cells, such as red blood cells (RBCs), immune cells, and even platelets all originate from the same progenitor cell, the hematopoietic stem cell (HSC). (wikipedia.org)
  • The CMP can then further differentiate into the megakaryocyte-erythroid progenitor cell (MEP), which goes on to make RBCs and platelets, or the granulocyte/macrophage progenitor (GMP), which gives rise to the granulocytes of the innate immune response. (wikipedia.org)
  • Pertaining to anti-inflammatory effects, reactive scar-forming astrocytes help reduce the spread of inflammatory cells during locally initiated inflammatory responses to traumatic injury or during peripherally-initiated adaptive immune responses. (wikipedia.org)
  • Form 2 is the most widely expressed form that is found in all circulating and immune cells. (wikipedia.org)
  • Pharmacological and genetic inhibition of p38α MAPK not only revealed its biological significance in physiological function but also the potential of targeting p38α MAPK in human diseases such as immune disorder and heart failure. (wikipedia.org)