Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES. Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms.
Protein factor(s) released by sensitized lymphocytes (and possibly other cells) that inhibit the movement of LEUKOCYTES, especially polymorphonuclear cells, away from their site of release. Assays for these factors are used as tests for cellular immunity. Two of the common assays are the LEUKOCYTE MIGRATION CAPILLARY TUBE TECHNIQUE (LMCT) and the LEUKOCYTE MIGRATION AGAROSE TEST (LMAT).
Proteins released by sensitized LYMPHOCYTES and possibly other cells that inhibit the migration of MACROPHAGES away from the release site. The structure and chemical properties may vary with the species and type of releasing cell.
Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
A protein extracted from boiled culture of tubercle bacilli (MYCOBACTERIUM TUBERCULOSIS). It is used in the tuberculin skin test (TUBERCULIN TEST) for the diagnosis of tuberculosis infection in asymptomatic persons.
Assays that measure the rate of migration of LEUKOCYTES. They may involve a variety of techniques such as measuring the movement of leukocytes through substrates such as AGAROSE gels or the rate of exit of cells from a glass capillary.
An increased reactivity to specific antigens mediated not by antibodies but by cells.
Factor derived from leukocyte lysates of immune donors which can transfer both local and systemic cellular immunity to nonimmune recipients.
Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.
Substances that are recognized by the immune system and induce an immune reaction.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.
Prolamins in the endosperm of SEEDS from the Triticeae tribe which includes species of WHEAT; BARLEY; and RYE.
The serous fluid of ASCITES, the accumulation of fluids in the PERITONEAL CAVITY.
An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.
One of several skin tests to determine past or present tuberculosis infection. A purified protein derivative of the tubercle bacilli, called tuberculin, is introduced into the skin by scratch, puncture, or interdermal injection.
Test for cell-mediated antitumor immunity and related serum blocking factors based on the finding that leukocytes from cancer patients, but not from controls, when mixed in vitro with antigenic extracts of tumors of the same histological type, undergo a diminution in their normal adherence to glass surfaces. Sera from tumor-bearing patients block the LAI reaction of their own leukocytes or those of other patients with the same type of tumor.
A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Specific assays that measure the migration of cells. They are commonly used to measure the migration of immune cells in response to stimuli and the inhibition of immune cell migration by immunosuppressive factors.
An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.
Adherence of cells to surfaces or to other cells.
Substances of fungal origin that have antigenic activity.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Substances elaborated by bacteria that have antigenic activity.
A series of steps taken in order to conduct research.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
A cell line derived from cultured tumor cells.
An encapsulated lymphatic organ through which venous blood filters.
A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.
The movement of cells or organisms toward or away from a substance in response to its concentration gradient.
Mucoproteins isolated from the kidney bean (Phaseolus vulgaris); some of them are mitogenic to lymphocytes, others agglutinate all or certain types of erythrocytes or lymphocytes. They are used mainly in the study of immune mechanisms and in cell culture.
Periodic movements of animals in response to seasonal changes or reproductive instinct. Hormonal changes are the trigger in at least some animals. Most migrations are made for reasons of climatic change, feeding, or breeding.
Established cell cultures that have the potential to propagate indefinitely.
The lack of sufficient energy or protein to meet the body's metabolic demands, as a result of either an inadequate dietary intake of protein, intake of poor quality dietary protein, increased demands due to disease, or increased nutrient losses.

Hypersensitivity pneumonitis: experimental production in calves with antigens of Micropolyspora faeni. (1/850)

Pneumonitis was induced in calves by exposure to aerosols of Micropolyspora faeni with or without prior sensitization of the animals by subcutaneous injection of antigen. The pneumonitis primarily involved centrolobular areas and was characterized by alveolar septal thickening and loss of air space by cellular infiltration. Vasculitis and focal haemorrhage occurred in certain individuals and haemoproteinaceous exudate appeared within septa and alveolar lumina. The pneumonitis was compared with human farmer's lung, pneumonitis of housed cattle and other experimental hypersensitivity pneumonitides.  (+info)

Lymphocyte proliferation inhibitory factor (PIF) in alcoholic liver disease. (2/850)

Lymphocyte proliferation inhibitory factor (PIF) was determined in the supernatants of PHA-stimulated lymphocytes from patients with alcoholic liver disease. PIF was assayed by determining inhibition of DNA synthesis in WI-38 human lung fibroblasts. A two-fold greater inhibition in thymidine incorporation into DNA by lung fibroblasts was observed in supernatants of PHA stimulated lymphocytes from patients with alcoholic hepatitis or active Laennec's cirrhosis as compared with that found in control subjects or patients with fatty liver. It is suggested that decreased liver cell regeneration seen in some patients with alcoholic hepatitis may be due to increased elaboration of PIF.  (+info)

Macrophage electrophoretic mobility (MEM) with myelin basic protein. (3/850)

Lymphocytes from a total of 161 subjects, including normal controls and patients with malignant and non-malignant conditions, have been investigated for their response to myelin basic protein, using the macrophage electrophoretic mobility (MEM) test. It has been confirmed that there was a high level of association between clinically evident cancer and a positive response. Lymphocytes from 24/25 patients with non-malignant inflammatory and ischaemic diseases also gave positive responses. In 46 patients with breast lumps studied before mastectomy or biopsy, the test was positive in 15/19 cases which proved to be malignant and in 5/27 which proved benign on histological examination. In its present form the test is not sufficiently reliable for the diagnosis of early cancer. Our results suggest that tissue necrosis in malignant and non-malignant conditions may be one of the factors resulting in sensitization to antigenic determinants present in preparations of myelin basic protein. Despite its technical difficulties, the test may provide a means of examing some aspects of immune recall not readily revealed by other test systems.  (+info)

Leucocyte migration inhibition with inner and outer membranes of mitochondria and insoluble hepatocyte surface membranes prepared from rat liver in patients with chronic hepatitis and cirrhosis. (4/850)

Patients with chronic liver disease were tested for delayed hypersensitivity to the outer and the inner membranes of mitochondria (OMM and IMM) and the insoluble hepatocyte-surface membranes (IHSM), prepared from rat livers, by means of leucocyte migration inhibition technique. Positive reaction to OMM was found in 37% of patients with chronic persistent hepatitis and 35% of those with chronic active hepatitis and 43% of those with liver cirrhosis (P less than 0-05). That to IMM was 55%, 43% and 36% (P less than 0-05) and to IHSM was 37%, 47% and 45% respectively (P less than 0-05). IHSM was found to contain liver-specific components and patients with positive response to IHSM did not reveal at all a positive reaction to rat renal cell-surface membranes. The incidence of positive response to IHSM was significantly higher (54-2%) in patients with the present or previous infection with HBAg than in HBAg-non-infected patients (21-4%) (P less than 0-05). And there seemed to be a good correlation between a degree of cellular response to purified HBsAg and that to IHSM in these HBAg-infected patients. No correlation, however, was found between that to purified HBsAg and that to OMM or IMM in the same patients. This suggested that the cellular response to either HBsAg or IHSM, both related closely, may play a role in the perpetuation of chronic liver disease.  (+info)

Cell-mediated immune responses in owl monkeys (Aotus trivirgatus) with trachoma to soluble antigens of Chlamydia trachomatis. (5/850)

The first temporal study of the cell-mediated immune responses (CMI) following ocular infections with Chlamydia trachomatis is presented. We examined the CMI of owl monkeys infected with trachoma to soluble antigens of C. trachomatis by leucocyte migration inhibition (LIF) and delayed hypersensitivity skin testing. Delayed hypersensitivity of a systemic nature developed after a local eye infection in owl monkeys; clearance of inclusions from conjunctival cells coincided with the onset of this response. The association of eye secretion and circulating antibodies with recovery from primary infection was not so striking. Both cellular and humoral immune responses persisted for at least 2 months, at which time all test animals were completely resistant to re-infection. The elicitation of cell-mediated immune reactions with solubilized chlamydial antigens may permit the isolation of specific antigens involved in the generation of protective immunity in the owl monkey model.  (+info)

Acquired cellular resistance, delayed hypersensitivity, and altered macrophage migration in Listeria monocytogenes-infected guinea pigs. (6/850)

A Listeria monocytogenes infection in guinea pigs was used to study the interrelationship between antigen-induced macrophage migration inhibition, delayed-type hypersensitivity, and acquired cellular resistance. Early after infection (at 2 and 7 days), very significant enhancement of macrophage migration was observed. Migration inhibition was detected beginning on day 14 and was uniformly observed only on day 21 of the infection, after which a shift again to enhancement was seen. The early detection (by day 2) of migration enhancement suggested that this assay may be more sensitive than assessment of delayed type hypersensitivity in vivo, which in this system was first detectable only on day 4. Acquired cellular resistance, as measured by enhanced survival following a high dose challenge with Listeria, was present from day 7 after infection until at least day 60. By splenic clearance studies, however, acquired cellular resistance was present only until day 14 after infection, suggesting that in this system splenic clearance was not a very reliable criterion for measuring acquired cellular resistance.  (+info)

Promotion of neutrophil chemotaxis through differential regulation of beta 1 and beta 2 integrins. (7/850)

Migration of neutrophils requires sequential adhesive and deadhesive interactions between beta 1 and beta 2 integrins and components of the extracellular matrix. Prompted by reports that describe interaction of soluble beta-glucan with the beta 2 integrin Mac-1, a role for beta-glucan in regulation of integrin-mediated migration was investigated. Neutrophil migration in response to fMLP was assessed using an agarose overlay method with slides precoated with fibronectin (Fn) +/- beta-glucan. On Fn, random migration in excess of directed migration was observed. In contrast, migration on Fn + beta-glucan was directional, with marked diminution of random migration. This conversion of random to directed migration was seen neither when Fn was supplemented with alternative polysaccharides nor when beta-glucan was applied to other components of the extracellular matrix. This effect of beta-glucan was shown to be cation dependent and to be effected by Arg-Gly-Asp-containing peptides consistent with an integrin-mediated event. mAb inhibition studies demonstrate that beta-glucan effects this shift toward directed migration through suppression of migration mediated by Mac-1 and very late Ag 5 and enhancement of very late Ag 3-mediated migration. Adhesion assays suggest that the prochemotactic influence of beta-glucan is due, in part but not entirely, to modulation of PMN adhesion to Fn. In summary, these data support a novel role for beta-glucan in regulation of beta 1- and beta 2-mediated neutrophil migration on Fn.  (+info)

Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4+ T cells. (8/850)

Because the binding of HIV-1 envelope to CD4 initiates a configurational change in glycoprotein 120 (gp120), enabling it to interact with fusion coreceptors, we investigated how this process interferes with the expression and function of CXC chemokine receptor 4 (CXCR4) in CD4+ T lymphocytes. A recombinant gp120 (MN), after preincubation with CD4+ T lymphocytes, significantly inhibited the binding and chemotaxis of the cells in response to the CXCR4 ligand stromal cell-derived factor-1alpha (SDF-1alpha), accompanied by a markedly reduced surface expression of CXCR4. gp120, but not SDF-1alpha, induced rapid tyrosine phosphorylation of src-like kinase p56lck in CD4+ T cells, whereas both gp120 and SDF-1alpha caused phosphorylation of the CXCR4. The tyrosine kinase inhibitor herbimycin A abolished the phosphorylation of p56lck and CXCR4 induced by gp120 in association with maintenance of normal expression of cell surface CXCR4 and a migratory response to SDF-1alpha. Thus, a CD4-associated signaling molecule(s) including p56lck is activated by gp120 and is required for the down-regulation of CXCR4.  (+info)

Examples of delayed hypersensitivity reactions include contact dermatitis (a skin reaction to an allergic substance), tuberculin reactivity (a reaction to the bacteria that cause tuberculosis), and sarcoidosis (a condition characterized by inflammation in various organs, including the lungs and lymph nodes).

Delayed hypersensitivity reactions are important in the diagnosis and management of allergic disorders and other immune-related conditions. They can be detected through a variety of tests, including skin prick testing, patch testing, and blood tests. Treatment for delayed hypersensitivity reactions depends on the underlying cause and may involve medications such as antihistamines, corticosteroids, or immunosuppressants.

The primary symptoms of celiac disease include diarrhea, abdominal pain, fatigue, weight loss, and bloating. However, some people may not experience any symptoms at all, but can still develop complications if the disease is left untreated. These complications can include malnutrition, anemia, osteoporosis, and increased risk of other autoimmune disorders.

The exact cause of celiac disease is unknown, but it is believed to be triggered by a combination of genetic and environmental factors. The disease is more common in people with a family history of celiac disease or other autoimmune disorders. Diagnosis is typically made through a combination of blood tests and intestinal biopsy, and treatment involves a strict gluten-free diet.

Dietary management of celiac disease involves avoiding all sources of gluten, including wheat, barley, rye, and some processed foods that may contain hidden sources of these grains. In some cases, nutritional supplements may be necessary to ensure adequate intake of certain vitamins and minerals.

While there is no known cure for celiac disease, adherence to a strict gluten-free diet can effectively manage the condition and prevent long-term complications. With proper management, people with celiac disease can lead normal, healthy lives.

Causes and risk factors:

1. Poverty and lack of access to nutritious food
2. Poor sanitation and hygiene
3. Inadequate healthcare and nutritional education
4. Conflict and displacement
5. Chronic illnesses such as HIV/AIDS and tuberculosis


1. Wasting and stunting of children
2. Poor appetite and weight loss
3. Fatigue, weakness, and lethargy
4. Increased susceptibility to infections
5. Poor wound healing and skin problems


1. Stunted growth and development
2. Weakened immune system
3. Increased risk of infections and diseases such as diarrhea, pneumonia, and malaria
4. Poor cognitive development and reduced educational attainment
5. Increased risk of mortality


1. Clinical evaluation of symptoms and physical examination
2. Anthropometric measurements such as height and weight
3. Laboratory tests to assess nutrient deficiencies and infections
4. Dietary assessment to determine food intake and nutrient adequacy

Treatment and prevention:

1. Providing access to nutrient-dense foods, particularly protein-rich foods such as meat, poultry, fish, beans, and dairy products
2. Addressing underlying causes such as poverty and poor sanitation
3. Implementing nutritional education programs to promote healthy eating habits
4. Providing micronutrient supplements and fortified foods
5. Addressing infectious diseases and providing appropriate medical care

In conclusion, protein-energy malnutrition is a serious condition that affects millions of people worldwide, particularly in developing countries. It can have severe consequences on physical growth, cognitive development, and overall health. Early diagnosis and treatment are crucial to prevent long-term health problems and improve quality of life. Addressing underlying causes such as poverty and poor sanitation is also essential to prevent the condition from occurring in the first place.

Contact inhibition of proliferation (CIP) is the inhibition of cell division with increasing percent of confluency. CIP and CIL ... Collective cell migration describes the movements of group of cells and the emergence of collective behavior from cell- ... While single-cell migration has been extensively studied, collective cell migration is a relatively new field with applications ... Collective cell migration is studied over many model species. Border cells in flies (Drosophila melanogaster): the border cells ...
"Inhibition of SNARE-mediated membrane traffic impairs cell migration". Experimental Cell Research. 305 (1): 63-73. doi:10.1016/ ... Bves demonstrates dynamic localization, dependent upon cell-cell junction formation. Prior to cell-cell contact, Bves is ... Disruption of Bves results in decreased cell speed and increased cell roundness, which are cell processes modulated by the Rho ... "Tetanus neurotoxin-mediated cleavage of cellubrevin impairs epithelial cell migration and integrin-dependent cell adhesion". ...
Further, this process promotes epithelial cell migration, proliferation and apoptosis. For menstruation, it promotes the ... and only hematopoietic cells remained after that time. In order for MMPs to escape TIMP inhibition, active MMP7s are recruited ... In human glioma cell lines and human squamous cell carcinoma cell line II-4, TGF-β stimulates the expression of MMP7 mRNA and ... MMP7 cleaves cell surface proteins, promotes adhesion of cancer cells, and increases the potential of tumor metastasis. Higashi ...
"KIF1A inhibition immortalizes brain stem cells but blocks BDNF-mediated neuronal migration". Nature Neuroscience. 19 (2): 253- ... cell body to axon terminal) and dendritic (cell body to dendrites) transport of cargo. The main function of KIF1A is the long- ... Molecular Cell Biology. 10 (12): 877-84. doi:10.1038/nrm2807. PMID 19935670. S2CID 27303652. Al-Bassam J, Nithianantham S ( ... KIF1A is one of the many motors that helps execute the transport of organelles within the cell through axonal anterograde cargo ...
Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by ...
3 human ovary cancer cells by inducing apoptosis, inhibition of cancer cell migration and G2/M phase cell cycle arrest ... Against ovarian cancer cells, it induced apoptosis, limited migration, and caused cell cycle arrest. This impact on cancer ... When studied against human prostate cancer cells, ferruginol similarly induced cell death by suppressing survival signaling ... In vitro studies have shown human colon, breast, and lung tumor reduction and reduction in oncogene transformed cells as well. ...
... angiogenesis and cell migration. Homologous subfamily of ADAMTSL (ADAMTS-like) proteins, which lack enzymatic activity, has ... Most cases of thrombotic thrombocytopenic purpura arise from autoantibody-mediated inhibition of ADAMTS13. Like ADAMs, the name ... Cell Biology. 15 (6): 981-985. doi:10.1016/j.biocel.2004.01.014. PMID 20036837. Kelwick, Richard; Desanlis, Ines; Wheeler, ...
Yang, Hailing; Ganguly, Anutosh; Cabral, Fernando (2010). "Inhibition of Cell Migration and Cell Division Correlates with ... Cell Migration Gateway The Cell Migration Gateway is a comprehensive and regularly updated resource on cell migration The ... "What is Cell Migration?". Cell Migration Gateway. Cell Migration Consortium. Archived from the original on 22 October 2014. ... The migration of cultured cells attached to a surface or in 3D is commonly studied using microscopy. As cell movement is very ...
This interaction inhibits the activation of MEK and ERK and even cell migration. In cancer tissues, where ARHI is not expressed ... ARHI influences also the cell cycle, specifically ARHI's strong inhibition of the cyclin D1 promoter. Cyclin D1 is an essential ... "The tumour suppressor DiRas3 interacts with C-RAF and downregulates MEK activity to restrict cell migration". Biology of the ... and its regulation by ARHI is critical in maintaining healthy cells. This is the mechanism by which ARHI inhibits cell growth ...
Yang H, Ganguly A, Cabral F (October 2010). "Inhibition of cell migration and cell division correlates with distinct effects of ... Severe side effects include low blood cell counts and shortness of breath. It should not be given to people who have a current ... Vinblastine works by blocking cell division. Vinblastine was isolated in 1958. An example of a natural herbal remedy that has ... Vinblastine treatment causes M phase specific cell cycle arrest by disrupting microtubule assembly and proper formation of the ...
... is thought to exert its effects through modulation of the growth, migration, and invasion of malignant cells. Other ... "Inhibition of ALK mutated neuroblastomas by the selective inhibitor PF-02341066". J Clin Oncol. 27 (15s. suppl, abstr 10008b): ... In March 2016, the U.S. Food and Drug Administration approved crizotinib in ROS1-positive non-small cell lung cancer. In ... About 4% of patients with non-small cell lung carcinoma have a chromosomal rearrangement that generates a fusion gene between ...
"Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration". ... directed migration and control of related cell mechanisms are mediated via the specific cell interaction between HA and cell ... the migration path through which neural crest cells migrate is rich in HA. HA is closely associated with the cell migration ... By providing the dynamic force to the cell, HA synthesis has also been shown to associate with cell migration. Basically, HA is ...
PLCγ1 is a cell growth factor from the PLC superfamily. PLCγ1 is used during the cell growth and in a cell migration and ... Mutations in PLCγ1 can lead to cancer cell proliferations and inhibition can lead to tumor growth. PLCγ1 is involved in cell ... This aspect of PLCγ1 also helps cancer migration and metastasis away from the original tumor cells. There is also a link ... Phospholipase C, gamma 1, also known as PLCG1,is a protein that in humans involved in cell growth, migration, apoptosis, and ...
Yang H, Ganguly A, Cabral F (October 2010). "Inhibition of cell migration and cell division correlates with distinct effects of ... Lower concentration affects microtubule dynamics and cell migration. Demecolcine is used for scientific research in cells. It ... thus arresting cells in metaphase and allowing cell harvest and karyotyping to be performed. During cell division, demecolcine ... Demecolcine inhibition of microtubules causes aneuploidy in mitotic cells where the microtubules fall apart or are suppressed ...
... "miR-340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met". Cancer. 117 (13): 2842 ... "Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity". Brain. 134 (Pt 12): 3578- ...
... caused the inhibition of recombinant interleukin-8 (IL-8) induced migration of the inflammatory cells. Two other pro- ... Gastric parietal cells are rich in mitochondria which provide energy in the form of ATP for cells by oxidative phosphorylation ... They also inhibit mast cell activation, and leukocyte and platelet adherence to the vascular endothelium. Thus, continuous ... In addition to inhibition of pro-inflammatory mediators, troxipide directly acts on the enzymes such as xanthine oxidase and ...
... cell growth, and migration. Allosteric regulation by metabolites. The regulation of the citric acid cycle is largely determined ... Koivunen P, Hirsilä M, Remes AM, Hassinen IE, Kivirikko KI, Myllyharju J (February 2007). "Inhibition of hypoxia-inducible ... In eukaryotic cells, the citric acid cycle occurs in the matrix of the mitochondrion. In prokaryotic cells, such as bacteria, ... The depletion of NADPH results in increased oxidative stress within the cell as it is a required cofactor in the production of ...
Conversely, stimulation of HSC CaSR via its agonist cinacalcet increases migration and engraftment of these cells in the bone ... Lymperi S, Ersek A, Ferraro F, Dazzi F, Horwood NJ (2011). "Inhibition of osteoclast function reduces hematopoietic stem cell ... immune cells, and even platelets all originate from the same progenitor cell, the hematopoietic stem cell (HSC). As these cells ... PAX5 and Notch mutations can result in B-cell and T-cell leukemias, respectively. Dysregulation of stromal cells can in some ...
"Sesquiterpene lactone suppresses vascular smooth muscle cell proliferation and migration via inhibition of cell cycle ... 265-. ISBN 0-8223-1019-8. Amaya S, Pereira JA, Borkosky SA, Valdez JC, Bardón A, Arena ME (October 2012). "Inhibition of quorum ...
On the other hand, silencing RhoA lessened androgen-regulated cell viability and handicapped prostate cancer cell migration. ... Inhibition of this pathway by its various components usually results in some level of improved re-myelination. After global ... rhoA+Protein at the US National Library of Medicine Medical Subject Headings (MeSH) RHOA Info with links in the Cell Migration ... A majority of this activity occurs in the leading edge of cells during migration in coordination with membrane protrusions of ...
Franco SJ, Huttenlocher A (September 2005). "Regulating cell migration: calpains make the cut". Journal of Cell Science. 118 ( ... Grieve S, Gao Y, Hall C, Hu J, Greer PA (August 2016). "Calpain Genetic Disruption and HSP90 Inhibition Combine To Attenuate ... There is evidence suggesting that the mechanism of action is through cleavage of substrates involved in cell migration, ... Hanna RA, Campbell RL, Davies PL (November 2008). "Calcium-bound structure of calpain and its mechanism of inhibition by ...
... monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration". Cardiovascular ... In skin, Langerhans cells strongly express ALOX5. Fibroblasts, smooth muscle cells and endothelial cells express low levels of ... mast cells, dendritic cells, and B-lymphocytes express ALOX5. Platelets, T cells, and erythrocytes are ALOX5-negative. ... and the pharmacological inhibition of ALOX5 in these human cell lines causes them to die by entering apoptosis. ALOX5 and its ...
Wnt signaling functions can be divided into axis patterning, cell fate specification, cell proliferation and cell migration. In ... "Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT". Cell. 165 (1): 45-60. doi:10.1016/j.cell.2016.02. ... Cell fate specification or cell differentiation is a process where undifferentiated cells can become a more specialized cell ... Wnt signaling also induces cell migration in later stages of development through the control of the migration behavior of ...
Molecular Mechanisms by Which S100A4 Regulates the Migration and Invasion of PGCCs With Their Daughter Cells in Human ... It is concluded that extracellular S100A4 inhibition is an attractive approach for the treatment of human cancer. S100A4 is ... This antibody abolished endothelial cell migration, tumor growth and angiogenesis in immunodeficient mouse xenograft models of ... in promoting endothelial cell migration by increasing KDR expression and MMP-9 activity. In vivo overexpression of S100A4 led ...
S100A4 expression is associated with enhanced cell migration through maintenance of cell polarization and inhibition of cell ... Ravid S (2014). "The tumor suppressor Lgl1 regulates front-rear polarity of migrating cells". Cell Adhesion & Migration. 8 (4 ... cell migration, polarization and adhesion, maintenance of cell shape, and signal transduction. Myosin IIs are motor proteins ... "Non-muscle myosin II takes centre stage in cell adhesion and migration". Nature Reviews. Molecular Cell Biology. 10 (11): 778- ...
It also induces apoptosis in leukocyte cancer cells and affects the invasion, migration and metastasis of those cells. This is ... with outliers of 30.22 and 116.96 μg/ml for the growth inhibition of AGS and Hepa1c1c7 cells respectively. The cytotoxic effect ... It has been shown to inhibit cell proliferation in certain cancer cell lines (AGS and Hepa 1c1c7 cells), which is possible by, ... Cynaropicrin inhibits the entry of pan-genomic Hepatitis C virus into cells and inhibits cell-cell transmission. Cynaropicrin ...
... acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration". ...
Also, the migration of adult neural progenitor cell and adult spinal cord progenitor cells to the spine is netrin 1 dependent. ... Little is known of the mechanism controlling the inhibition or attraction of these stem cells. In various human cancers, it has ... Netrin contributes to tissue morphogenesis by controlling developing cell migration and cell adhesion in different organs. In ... Von Hilchen, C. M.; Hein, I.; Technau, G. M.; Altenhein, B. (2010). "Netrins guide migration of distinct glial cells in the ...
In epithelial cells inhibition of ROCK seems to decrease tight junction integrity. Active ROCK in these cells seems to ... For example, such drugs have potential to prevent cancer from spreading by blocking cell migration, stopping cancer cells from ... ROCKs regulate cell-cell adhesion: Loss of ROCK activity seems to lead to loss of tight junction integrity in endothelial cells ... Cellular contractility ROCK also regulates cell migration by promoting cellular contraction and thus cell-substratum contacts. ...
"Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein- ... Kinases of GCKIII subfamily are involved in regulation of multiple functions of the cells and interaction with programmed cell ... Cell. 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. (Genes on human chromosome 13, Biology of bipolar ... "CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation". Journal of Cell Science. 123 (Pt 8): ...
Any changes in cytoskeletal organization and adhesion can lead to altered signaling, migration and a loss of contact inhibition ... F9 embryonal carcinoma cells are similar to the P19 cells shown in Figure 1 and normally have cell-to-cell adhesion mediated by ... A tumor cell line with defective δ-catenin, low levels of E-cadherin and poor cell-to-cell adhesion could be restored to normal ... providing the cell with a means of stable cell adhesion. However, decreases in this adhesion ability of the cell has been ...
Molecular Cell Biology. 20 (11): 665-680. doi:10.1038/s41580-019-0133-3. PMID 31253954. S2CID 195739183. Kishor A, White EJ, ... and inhibition of apoptosis in ovarian, bladder urothelial, and breast cancers. Patients with chronic hepatitis B or hepatitis ... expression in bladder urothelial carcinoma is associated with tumour progression and promotes migration and invasion". European ... Hsp70-2 specifically is developmentally expressed in male germ line cells during meiosis, where it is necessary for the ...
The Interactive Fly ABL1 Info with links in the Cell Migration Gateway ABL1 on the Atlas of Genetics and Oncology Human ABL1 ... "Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides". Science. 253 (5019): 562-5. ... cell division, cell adhesion, and stress response such as DNA repair. Activity of ABL1 protein is negatively regulated by its ... a site for phosphorylation in leukaemia cells". Genes to Cells. 9 (9): 781-90. doi:10.1111/j.1365-2443.2004.00772.x. PMID ...
Cancer cells are known for their limitless cellular replicative potential, and it has been hypothesized that changes in ... inhibits the migration and proliferation of arterial myocytes". Eur. J. Pharmacol. 355 (1): 77-83. doi:10.1016/S0014-2999(98) ... apoptosis inhibition, angiogenesis, and metastasis. Thromboxane synthesis Eicosanoid synthesis Prostanoid 12- ... This enzyme, anchored to the endoplasmic reticulum, is found in platelets, monocytes, and several other cell types. The NH2 ...
"The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells". ... Cerrizuela S, Vega-López GA, Palacio MB, Tríbulo C, Aybar MJ (August 2018). "Gli2 is required for the induction and migration ... However, loss of Gli3 leads to abnormal patterning and loss of Gli2 affects the development of ventral cell types, most ... migration and differentiation of the neural crest. In this context, Gli2 is responding to the Indian Hedgehog signaling pathway ...
qM is a measure of chloroplast migration, and qI is a measure of plant photoinhibition. At lower actinic light levels NPQ = qE+ ... Plant Symposium of the SEB: Oxidative stress and cell death in plants: mechanisms and implications, Florence, Italy, 26-28 June ... doi:10.1016/S0304-4165(89)80016-9. Haldimann, P.; Feller, U. (2004). "Inhibition of photosynthesis by high temperature in oak ( ... High performance imaging fluorometer systems provide options to analyze single cell/single chloroplast as well as sample areas ...
Cell. Biol. 16 (4): 1770-6. doi:10.1128/MCB.16.4.1770. PMC 231163. PMID 8657152. Crk Info with links in the Cell Migration ... Qiu W, Cobb RR, Scholz W (1998). "Inhibition of p130cas tyrosine phosphorylation by calyculin A". J. Leukoc. Biol. 63 (5): 631- ... alters cell morphology upon translocation to the cell membrane". Mol. Cell. Biol. 16 (4): 1770-6. doi:10.1128/MCB.16.4.1770. ... 1996). "DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane". Mol. ...
N Olea-Herrero; D Vara; S Malagarie-Cazenave; I Díaz-Laviada (18 August 2009). "Inhibition of human tumour prostate PC-3 cell ... "CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways". ...
Yang H, Ganguly A, Cabral F (October 2010). "Inhibition of cell migration and cell division correlates with distinct effects of ... Some cell types, such as plant cells, do not contain well defined MTOCs. In these cells, microtubules are nucleated from ... This interference with microtubule dynamics can have the effect of stopping a cell's cell cycle and can lead to programmed cell ... In these cells, the microtubules play important roles in cell migration. Moreover, the polarity of microtubules is acted upon ...
Shaulian E, Karin M (May 2002). "AP-1 as a regulator of cell life and death". Nature Cell Biology. 4 (5): E131-6. doi:10.1038/ ... Gibbings DJ, Ghetu AF, Dery R, Befus AD (February 2008). "Macrophage migration inhibitory factor has a MHC class I-like motif ... "The antiaging activity of ergothioneine in UVA-irradiated human dermal fibroblasts via the inhibition of the AP-1 pathway and ... For example, inactivated c-Jun-ER cells show a normal morphology, while c-Jun-ER activated cells have been shown to be ...
Studies in Drosophila first suggested Numb played a role in cell migration when mutants displayed defective glial migration ... suggesting Numb promotes acquisition of the pIIb cell fate through inhibition of Notch signaling. Thus, the asymmetric ... The pIIa cell divides to produce a bristle cell and a socket cell, while the pIIb cell divides to produce a neuron and a glial ... The other daughter cell becomes a progenitor cell to fill the lost role of the parent cell and maintain proliferation. In ...
His work in 2005 on the regulation of adhesion, migration and polarity of the cell cytoskeleton was awarded the Louis-Jeantet ... The inhibition of Rho by C3 transferase ribosylation resulted in an inhibition of focal adhesion and stress fibre assembly, but ... DNA from a rhabdomyosarcoma cell line and a fibrosarcoma cell line transformed a NIH/3T3 mouse fibroblast cell line. After ... "Prominent Cell Biologist Dies". In Memoriam: Alan Hall, Pioneer in Rho GTPases and Chair of Cell Biology at Sloan-Kettering "At ...
... and thus all cells, and that are currently used clinically. Inhibition of Kinesin-5 causes cells to undergo mitotic arrest, ... Falnikar A, Tole S, Baas PW (2011). "Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migration". ... Although Kinesin-5 is required in all cells during cell division, it does not appear to play a major role in the metabolism of ... Liu M, Aneja R, Liu C, Sun L, Gao J, Wang H, Dong JT, Sarli V, Giannis A, Joshi HC, Zhou J (2006). "Inhibition of the mitotic ...
The chance of a copying error in DNA replication during cell division increases with the number of cell divisions, and an ... A personal or recent family history of migration is a considerable risk factor for schizophrenia, which has been linked to ... including reduced latent inhibition), and an attentional bias toward threats. Some of these tendencies have been shown to ... due to cell-by-cell encoding of schizophrenia-related neuropathology. A genetic predisposition on its own, without superimposed ...
2014-05-26). "Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin Cytoskeleton". ... Coelingh Bennink HJ, Skouby S, Bouchard P, Holinka CF (March 2008). "Ovulation inhibition by estetrol in an in vivo model". ... This property of estetrol is associated with antagonistic effects on breast cell proliferation, migration and invasion in the ... Estetrol is equally distributed between red blood cells and plasma. Cytochrome P450 (CYP) enzymes do not play a major role in ...
"Macrophage Migration Inhibitory Factor Is Induced by Thrombin and Factor Xa in Endothelial Cells". Journal of Biological ... Ashcroft, Gillian S.; Mills, Stuart J. (1 September 2002). "Androgen receptor-mediated inhibition of cutaneous wound healing". ... "Red cell, plasma and blood volume in healthy men measured by radiochromium (Cr51) cell tagging and hematocrit: influence of age ... Sex hormones may influence female hippocampal cells to tolerate brain damage better than the same cells in men. The studies of ...
"Gβγ Signaling to the Chemotactic Effector P-REX1 and Mammalian Cell Migration Is Directly Regulated by Gαqand Gα13 Proteins". J ... mutation is associated with the development of uveal melanoma and its pharmacological inhibition (cyclic depsipeptide FR900359 ... Since cells actively sequester calcium in the ER to keep cytoplasmic levels low, this release causes the cytosolic ... Alberts B, Lewis J, Raff M, Roberts K, Walter P (2002). Molecular biology of the cell (4th ed.). New York: Garland Science. ...
Inflammation can contribute to proliferation, survival, angiogenesis and migration of cancer cells by influencing the tumor ... DNA repair inhibition is proposed to be a predominant mechanism in heavy metal-induced carcinogenicity. In addition, frequent ... For a normal cell to transform into a cancer cell, the genes that regulate cell growth and differentiation must be altered. The ... such as giant cell carcinoma, spindle cell carcinoma and small-cell carcinoma. An invasive ductal carcinoma of the breast (pale ...
However, there is substantial evidence that implicates S1P to cell survival, cell migration, and inflammation. Certain growth- ... Zhou, H. L.; Summers, S. K.; Birnbaum, M. J.; Pittman, R. N. (1998). "Inhibition of Akt kinase by cell-permeable ceramide and ... Ceramide mediates many cell-stress responses, including the regulation of programmed cell death (apoptosis) and cell aging ( ... whereby the cells differentiated into white blood cells called macrophages. Treatment of the same cells by exogenous Sph caused ...
... of cell surface receptors expressed by leukocytes that are important for cell migration and the recognition of abnormal cells ... It has been shown that inhibition of tyrosine phosphatases induces phosphorylation in NTRs and signalling even without ligand ... Evidence for this model is given by the observation that in T cells, phosphatases CD45 and CD148 segregate from the T-cell ... Cell. 135 (4): 702-13. doi:10.1016/j.cell.2008.09.044. PMC 2597348. PMID 19013279. Fernandes RA, Yu C, Carmo AM, Evans EJ, van ...
... junctions permit migration of the ALP enzymes until the polarity is reversed and the enzymes are found on the whole of the cell ... Another target for inhibition, MRP2 is an apical efflux transporter that mainly exports bilirubin glucuronide and glutathione ... In PBC, the liver is filled with T cells and B cells that contribute to a worsening condition. Therefore, some treatments are ... Giant cell formation is likely caused by the detergent properties of bile salts causing a loss of the lateral membrane and ...
"Controlled Inhibition of the Mesenchymal Stromal Cell Pro-inflammatory Secretome via Microparticle Engineering". Stem Cell ... "Rudhira/BCAS3 couples microtubules and intermediate 1 filaments to promote cell migration for angiogenic remodeling." Molecular ... Inamdar's group works on the basic biology of stem cells. The group led by her has developed normal stem cell lines from ... She is presently Director of inStem (Institute for Stem Cell Science and Regenerative Medicine), India's first stem cell ...
... active in the cell membrane and activates its downstream effectors that are involved in cell proliferation and migration. The ... By inhibition of the ligase activity (through the making of Cul1 dominant negative thus renders ubiquitination not to occur), ... Skaar JR, Pagano M (December 2009). "Control of cell growth by the SCF and APC/C ubiquitin ligases". Current Opinion in Cell ... The loss of p53 and Rb in cells allows limitless cell proliferation to occur. Gene amplification often occur in various tumor ...
Inhibition of cancer progression occurs through mir-126s negative control of proliferation, migration, invasion and cell ... This includes controlled cell death and responses to wounds. During apoptosis cell death, cells release apoptotic bodies ... Increased expression of mir-126 inhibits cell proliferation of non-small cell lung carcinoma cells in vitro and prevents tumour ... EGFL7 is known to be involved in cell migration and blood vessel formation, making EGFL7 and mir-126 opportune targets for ...
... cell-autonomous and self-sustained oscillators pass time to daughter cells". Cell. 119 (5): 693-705. doi:10.1016/j.cell.2004.11 ... This inhibition lasts as long as the protein, or the mRNA is not degraded. When this happens, the complex releases the ... The navigation of the fall migration of the Eastern North American monarch butterfly (Danaus plexippus) to their overwintering ... It is now known that the molecular circadian clock can function within a single cell. That is, it is cell-autonomous. This was ...
It seems to be a paradox that FAK is not absolutely required for cell migration, and may play other roles in the cell, ... Overexpression of FAK leads to inhibition of apoptosis and an increase in the prevalence of metastatic tumors. Focal adhesion ... most cells express FAK. FAK tyrosine kinase activity can be activated, which plays a key important early step in cell migration ... "FAK integrates growth-factor and integrin signals to promote cell migration". Nature Cell Biology. 2 (5): 249-56. doi:10.1038/ ...
... is involved in chemokine-induced T cell migration and T cell receptor (TCR)-mediated integrin activation. In lymphocytes ... Inhibition of AURKA and HDAC6 activity by alisertib and tubastatin A in xenograft models of breast cancer has led to a decrease ... Tikhmyanova N, Tulin AV, Roegiers F, Golemis EA (2010). "Dcas supports cell polarization and cell-cell adhesion complexes in ... cell migration, and adhesion. In B cells, NEDD9 association with NSP3 enhances integrin-mediated NEDD9 serine/threonine ...
It is differentiated from other mammalian acid phosphatases by its resistance to inhibition by tartrate and by its molecular ... TRAP is associated with osteoclast migration to bone resorption sites, and, once there, TRAP is believed to initiate osteoclast ... December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 ... These include leukaemic reticuloendotheliosis (hairy cell leukaemia), Gaucher's disease, HIV-induced encephalopathy, ...
As AMF, GPI is attributed with regulating cell migration during invasion and metastasis. One study showed that the external ... "GPI/AMF inhibition blocks the development of the metastatic phenotype of mature multi-cellular tumor spheroids". Biochimica et ... In addition, GPI is secreted exclusively by tumor cells and not normal cells. For these reasons, GPI inhibitors may be a safer ... Neuroleukin also acts as a lymphokine secreted by T cells stimulated by lectin. It induces immunoglobulin secretion in B cells ...
B-cell migration/adhesion, cell-cell interactions in immune niches and the production and class-switching of immunoglobulins. ... Consistent with these findings, inhibition of pre-miR712 increases expression of TIMP3 in cells, even when exposed to turbulent ... and cell cycle in mice lacking miRNA-1-2". Cell. 129 (2): 303-17. doi:10.1016/j.cell.2007.03.030. PMID 17397913. Thum T, ... In malignant B cells miRNAs participate in pathways fundamental to B cell development like B-cell receptor (BCR) signalling, ...
... migration, and invasion of bladder cancer EJ cells; involvement of G(2)/M-phase cell cycle arrest, signaling pathways, and ... Angiopoietin-like protein 4 potentiates DATS-induced inhibition of proliferation, ...
Lung cells; Dusts; Immune reaction; Nitric oxide; Chemical inhibition; Laboratory animals; Laboratory testing; Cell migration; ... Cellular effects; Cellular reactions; Enzyme inhibitors; Cell culture techniques; Cell cultures; Cell type; Cell signaling ... we have reported that bronchial epithelial cell exposure to swine CAFO dust significantly blunts normative cell migration and ... Results: Migration of epithelial cell monolayers from wild type mice significantly promoted repair of the ECIS-standardized ...
Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3. Proc Natl Acad Sci U S A. 2018;115(27):7057-7062. doi: ... Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer. Cell. 2017;171(7):1611- ... Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis. Cold ... Klarman Cell Observatory The Klarman Cell Observatory is systematically defining mammalian cellular circuits, how they work ...
Brown HO, Levine ML, Lipkin M. Inhibition of intestinal cell renewal and migration induced by starvation. Am J Physiol 1963;205 ... For instance, bloody diarrhea or the presence of white blood cells on methylene blue stain of the stool specimen suggests a ... However, fasting can reduce enterocyte renewal (72). Enteral nutrition stimulates intestinal cell renewal in several ways. In ...
The effect on the inhibition of cell migration was studied by transwell migration assay. An EAC (Ehrlich Ascites carcinoma) ... It induces cell death by activation of the intrinsic pathway of apoptosis both in vitro and in vivo. It also inhibits migration ... ST09 arrests the cell cycle in a cell type-specific manner and induces an intrinsic apoptotic pathway both in vitro and in vivo ... Annexin-FITC, cell cycle analysis using flow cytometry, and Western blotting were performed to elucidate cell death mechanisms ...
Cell Migration Inhibition E1.450.495.150 G4.335.283.337. E5.478.150. Centers for Disease Control and Prevention (U.S.). I1.409. ... Leukocyte Adherence Inhibition Test E5.478.640 E5.478.594.500. Leukocyte Migration-Inhibitory Factors D23.125.477. Limb Bud ... Leukemia, B-Cell C4.557.337.428.500 C4.557.337.428.80. C15.604.515.560.80. C20.683.515.528.80. Leukemia, B-Cell, Chronic C4.557 ... Tumor Stem Cells A11.872.910 A11.872.650. (Replaced for 2008 by Neoplastic Stem Cells). Umbilical Arteries A16.254.789.641 ...
... and cell counting kit-8 assay were used for monitoring the effect of circACTG1 in HCC cell invasion, migration, and ... miR-940 inhibition reversed circACTG1 expression in 97H cells with circACTG1 knockdown. Moreover, the expression of RIF1 was ... Knockdown of circACTG1 restrained 97H and Huh7 cell migration and invasion. Significantly, circACTG1 was discovered to serve as ... Moreover, circACTG1 potentially regulates HCC cell proliferation, invasion, and migration via miR-940/RIF1/AKT/mTOR pathway. ...
It is also demonstrated that HDAC6 knockdown will affect both proliferation and migration of the SMG cell lines. Overall, it ... Computational and pharmacological characterization of HDAC6 inhibition and function Author: Maguire, Aaron ISNI: 0000 0004 9348 ... Newly isolated cell lines, SMGs, were characterised to be high grade serous ovarian cancer and tested with common ... Potential binding cavities have been mapped that will, hopefully, allow for further inhibition of HDAC6 outside of the active ...
Metabolic reprogramming of immune cells is essential for both inflammatory as well as anti-inflammatory responses. Four anti- ... T cells and CD8+ memory T cell function.123,124 Similarly, glycolysis in endothelial cells promotes cell migration and is ... Inhibition of mTOR during T cell activation favored the generation of a specific subset of memory-like Treg cells with a ... regulatory T cells, CD56bright NK cells and plasmacytoid dendritic cells accompanied by a decrease in CD8+ T cells, B cells and ...
Brown HO, Levine ML, Lipkin M. Inhibition of intestinal cell renewal and migration induced by starvation. Am J Physiol 1963;205 ... For instance, bloody diarrhea or the presence of white blood cells on methylene blue stain of the stool specimen suggests a ... However, fasting can reduce enterocyte renewal (72). Enteral nutrition stimulates intestinal cell renewal in several ways. In ...
... resulted in decreased cell proliferation, cell migration, invasion, colony-forming abilit … ... Treatment of AGS GC cells with a CAMKK2 inhibitor, STO-609, ... Moreover, inhibition of CAMKK2 and MEK1 resulted in decreased ... Treatment of AGS GC cells with a CAMKK2 inhibitor, STO-609, resulted in decreased cell proliferation, cell migration, invasion ... Quantitative phosphoproteomics in AGS cells with the CAMKK2 inhibitor led to the identification of 9603 unique phosphosites ...
... the transition from a neuroendocrine state to a more neuronal state endows these cancer cells with increased migration and ... and neuronal migration also reduced cell migration (Figure 3B). Quantification of cell migration showed that inhibition of ... on small-cell lung Cancer cells mediates migration, integrin activation, and adhesion to stromal cells Oncogene 22:8093-8101. ... Quantification of the migration of cells with protrusions when mGFP-labeled N2N1G mSCLC cells were allowed to grow into a cell- ...
... it was speculated that miR-130a may exert its promoting effect on HeLa cell migration and invasion via inhibition of TIMP2 ... Knockdown of miR-130a inhibits HeLa-cell migration and invasion. As miR-130a was highly expressed in HeLa cells, this cell line ... the suppressive effects of miR-130a inhibition on the migration and invasion of HeLa cells, suggesting that the promoting role ... knockdown of TIMP2 rescued the suppressive effects of miR-130a inhibition on the migration and invasion of HeLa cells. ...
Binding to a multifunctional docking site mediates cell survival and migration. J Biol Chem. 1999 Oct 22;274(43):30896-905 ... J:297953 Ding X, et al., Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without ... Click on grid cells to view annotations.. *Blue cells = expressed in wild-type.. Gray triangles = other expression annotations ...
... on the selective inhibition of beta3-integrin directed endothelial cell migration by pathogenic hantaviruses. Cytotoxic T cells ... As reported by B. Hjelle (Albuquerque, NM), heat shock in cell cultures and cold shock in vivocan reactivate SNV, which ... Several reports on multiple cytokine mRNA and protein responses in cultured cells and in patients were, to say the least, ...
"Haptotactic gradients for directed cell migration: stimulation and inhibition using soluble factors." Combinatorial Chemistry ... "Directed cell migration on fibronectin gradients: effect of gradient slope." Experimental Cell Research 312, no. 13 (August ... "Bi-ligand surfaces with oriented and patterned protein for real-time tracking of cell migration." Colloids and Surfaces. B, ... "Measurement of cell migration on surface-bound fibronectin gradients." Langmuir 20, no. 19 (September 14, 2004): 8279-86. https ...
Directed migration or chemotaxis of arterial smooth muscle cells (SMC) contributes to intimal SMC accumulation, a key event in ... Inhibitors of protein kinases and calmodulin-dependent enzyme system did not prevent the PUFA-induced migration inhibition, ... Analysis of the phenotype of cells undergoing apoptosis revealed that cell death was not confined to a specific T cell subset ... The PUFA concentration required to inhibit migration was dependent on cell number, suggesting that the fatty acid effects on ...
Publications] Kurose I, et al: Inhibitions of platelet-octivating factor production Pathophysiology. 2. 153-159 (1995). *. ... Publications] Miura S. et al: Intravital demonstration of sequential migration Gastroenterology. 109. 113-1123 (1995). *. ... Hepatoma cell / Kupffer cell / NO / TNF-alpha / NF-kappaB / Adhesion molecules / Apoptosis / Laser scanning confocal microscope ... Publications] Fukumura D,et al.: Role of nitric oxide in Kupffer cell-mediated hepatoma cell cytotoxicity in vitro and ex vivo ...
Endostatin induces apoptosis and reduces cell proliferation and migration of endothelial cells through inhibition of cyclin D1 ... from endothelial cells to allow for migration of endothelial cells [22]. However, MMPs might cleave endostatin from collagen ... It inhibits endothelial cell proliferation and migration [5]. It is an abundant proteoglycan in vascular basement membranes and ... Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. Journal of biological chemistry, 2002, 277(19 ...
Endostatin induces apoptosis and reduces cell proliferation and migration of endothelial cells through inhibition of cyclin D1 ... from endothelial cells to allow for migration of endothelial cells [22]. However, MMPs might cleave endostatin from collagen ... It inhibits endothelial cell proliferation and migration [5]. It is an abundant proteoglycan in vascular basement membranes and ... Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. Journal of biological chemistry, 2002, 277(19 ...
Pharmacological inhibition of TPC2 negatively affected axonal growth and migration of interneurons. Our data, taken together, ... Rac1 and Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons In collection: Cell ... Call for papers: Cell and Tissue Polarity. We are welcoming submissions for our next special issue, which will focus on Cell ... Reasons to submit to Journal of Cell Science. There are many benefits to publishing through Journal of Cell Science, follow ...
Inhibition of wild type CXCR1 transfected in mouse L1.2 cells assessed as inhibition of CXCL8-induced cell migration pretreated ... Affinity DataIC50: 31nMAssay Description:Inhibition of CXCR1 (unknown origin) transfected with RBL cellsMore data for this ... Affinity DataIC50: 22nMAssay Description:Antagonist activity at CXCR1 assessed as inhibition of CXCL8 binding by cell based ... transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this ...
... and migration of inflammatory cells. Corticosteroids are thought to act by inhibition of phospholipase A2 via induction of ... Risk for implant migration into anterior chamber if the posterior capsule of the lens is absent or has a tear ...
Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTOR. Biochemical ... Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by ... Dendritic Cell Migration and Antigen Presentation Are Coordinated by the Opposing Functions of the Tetraspanins CD82 and CD37. ... Journal of cell science. 2020. ISSN 1477-9137. Ursino, Gloria M et al.. ABCA12 regulates insulin secretion from β‐cells. EMBO ...
Wound healing assay and Transwell assay were carried out to access the cell migration and invasion ability. RESULTS:It was ... In vitro experiments demonstrated that over-expression of CLCA4 could inhibit cell migration and invasion by suppressing ... In order to explore the functional role of CLCA4, gain-of-function cell models were constructed in SW620 and LoVo cells. ... CONCLUSIONS:CLCA4 inhibits migration and invasion by suppressing EMT via PI3K/ATK signaling and predicts favorable prognosis of ...
Inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of ... Inhibition of NF-kappaB pathway in grape seed extract-induced apoptotic death of human prostate carcinoma DU145 cells. Int J ... gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. ... A polyphenolic fraction from grape seeds causes irreversible growth inhibition of breast carcinoma MDA-MB468 cells by ...
... inhibition and increased migration but also allows tumor cell recognition and killing by DNAM-1 or CD96 expressing NK cells (1 ... which may play a role in cancer cell invasion and migration, binds other molecules including Vitronectin, Nectin-3, DNAM-1/ ... Binding of monocyte DNAM-1 to endothelial cell CD155 promotes transendothelial migration (8). The expression of CD155 on mouse ... and tumor cells of epithelial and neuronal origin (1, 2, 6-9). It is preferentially expressed on Th17 cells compared to Th2 ...
These data suggest a novel mechanism of T cell homeostasis wherein GPCR may promote T cell migration to distinct location- ... In vitro, however, neither GPCR inhibition nor chemokine stimulation affected T cell atrophy, survival, or proliferation. These ... by treatment with pertussis toxin led to T cell atrophy and shortened life-span in T cell-replete hosts and prevented T cell ... T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit ...
  • Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis. (
  • To date, most high-throughput screening models for cell migration, an integral component of cancer metastasis, were based on in vitro studies of cells. (
  • Demonstrating the utility of this approach, we confirmed that inhibition of the Src pathway prevented normal lateral line migration and decreases tumor metastasis in vivo . (
  • CLCA4 inhibits migration and invasion by suppressing EMT via PI3K/ATK signaling and predicts favorable prognosis of CRC which may help to distinguish potential risk of lymph node metastasis in CRC. (
  • Cancer stem cells are related to tumor metastasis and relapse after standard treatment in NPC [ 7 ]. (
  • Curcumin suppresses metastasis in colorectal cancer (CRC) by modulating crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment, at least in part by the mediation of transforming growth factor-β (TGF-β) and epithelial-mesenchymal transition (EMT) [ 11 ]. (
  • 11. IIp45 inhibits cell migration through inhibition of HDAC6. (
  • Disruption of these axon-like protrusions impairs cell migration in culture and inhibits metastatic ability in vivo. (
  • In summary, the present study suggests that HPV18 E6 promotes the expression of miR‑130a, which further inhibits the expression of TIMP2 and promotes cervical cancer cell invasion. (
  • It inhibits endothelial cell proliferation and migration [5]. (
  • We provide evidence that TBC1d24, a putative Rab35-GTPase activating protein (Rab35 GAP), complexes with ephrinB2 via the scaffold Dishevelled (Dsh), and mediates a signal affecting contact inhibition of locomotion (CIL) in CNC cells. (
  • Enhanced CD155 expression in tumor cells contributes to loss of contact inhibition and increased migration but also allows tumor cell recognition and killing by DNAM-1 or CD96 expressing NK cells (1, 7, 12). (
  • Previously, we have reported that bronchial epithelial cell exposure to swine CAFO dust significantly blunts normative cell migration and wound repair via a PKC-dependent mechanism. (
  • Results: Migration of epithelial cell monolayers from wild type mice significantly promoted repair of the ECIS-standardized wound as determined by resistance. (
  • Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3. (
  • Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES . (
  • Using our in vitro tube formation assay by the human microvascular endothelial cells (HMVEC), we have tested the inhibitory effect of catechins on vascular endothelial growth factor (VEGF} signaling during angiogenesis. (
  • In vitro experiments demonstrated that over-expression of CLCA4 could inhibit cell migration and invasion by suppressing epithelial-mesenchymal transition (EMT) via PI3K/ATK signaling and change the expression patterns of EMT markers in CLCA4-gain-of-function cell models. (
  • Specifically, we have found that green tea catechins' inhibition of angiogenesis in HMVEC is mediatedl: 1) by disruption of vascular endothelial (VE)-cadherin/b-catenin complex, and inhibition of Akt phosphorylation, a downstream molecular pathway implicated in angiogenesis, and 2) by inhibition of oxidative stress-induced interleukin (IL)-8 production, a potent angiogenic factor. (
  • VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. (
  • Vascular endothelial growth factor (VEGF) induces phosphorylation of VEGF receptor-2 (VEGFR-2) and activates the downstream signaling pathway resulting in endothelial cell migration, proliferation, and survival. (
  • Herein, we investigated the mechanism of cigarette smoke (CS) -induced endothelial dysfunction by studying the VEGF-VEGFR-2 signaling in mouse lung and human endothelial cells. (
  • CS exposure caused oxidative stress, as shown by increased levels of 4-hydroxy-2-nonenal-adducts in mouse lung and reactive oxygen species generation in human lung microvascular endothelial cells (HMVEC-Ls). (
  • CS down-regulated VEGFR-2 expression, eNOS levels, and VEGF-induced VEGFR-2 phosphorylation in HMVEC-Ls, resulting in impaired VEGF-induced endothelial cell migration and angiogenesis. (
  • CD155 is up-regulated on endothelial cells by IFN-gamma and is highly expressed on immature thymocytes, lymph node dendritic cells, and tumor cells of epithelial and neuronal origin (1, 2, 6-9). (
  • This dependence on glycolysis is seen in classically activated M1 macrophages, monocytes, educated NK cells, activated B cells and effector T cells including T-helper (Th) 1 and Th17 cells where glycolysis is required for proper differentiation and immune effector functions. (
  • 7. Notch signaling modulates hypoxia-induced neuroendocrine differentiation of human prostate cancer cells. (
  • Through mediating the expression of their target genes, miRs are involved in various cellular biological processes, including cell proliferation, differentiation, migration and invasion, as well as tumorigenesis ( 9 - 11 ). (
  • In particular, although some downstream effects of SRY are known, such as cellular proliferation, Sertoli cell differentiation, and testis-specific vascularization, the direct transcriptional targets of SRY remain unknown. (
  • Circular RNAs (circRNAs) are involved in cancer development via inhibition of miRNAs, which are associated with differentiation, proliferation, migration, and carcinogenicity. (
  • Moreover, circACTG1 potentially regulates HCC cell proliferation, invasion, and migration via miR-940/RIF1/AKT/mTOR pathway. (
  • c) Green tea catechins inhibit VEGF-induced IL-8 activation, and that this inhibition is mediated through a decrease in the PI3-kinase/Akt pathway leading to decrease of NF-kB activation. (
  • This hypothesis will be tested by blocking the PI3-kinase/Akt pathway using wortmanin inhibition and measuring IL-8 production, IL-8 mRNA expression, and NF-kB activation. (
  • Curcumin attenuates the malignant potential of glioblastoma stem cells by induction of reactive oxygen species (ROS) and activation of the mitogen-activated protein kinase (MAPK) pathway [ 10 ]. (
  • 8. Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner. (
  • Catechins can contribute to cancer prevention not only by the reduction of tumor cell growth, migration and invasion, but also by the inhibition of angiogenesis, an obligatory process for tumor growth. (
  • However, the exact molecular target(s) of catechins on the inhibition of angiogenesis is yet to be elucidated. (
  • Validation of this model would help in better understanding the specific molecular targets of tea catechins' induced inhibition of angiogenesis and in developing future studies to develop cost-effective strategies to fight against cancer. (
  • We show that treatment of human glioblastoma multiforme (GBM) tumour cells with imatinib and the closely-related drug, nilotinib, strikingly increases tyrosine phosphorylation of p130Cas, focal adhesion kinase (FAK) and the downstream adaptor protein paxillin (PXN), resulting in enhanced cell migration and invasion. (
  • 9. Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement. (
  • SCLC cells normally express neuroendocrine and neuronal gene programs but accumulating evidence indicates that these cancer cells become relatively more neuronal and less neuroendocrine as they gain the ability to metastasize. (
  • The formation of these protrusions is controlled by multiple neuronal factors implicated in axonogenesis, axon guidance, and neuroblast migration. (
  • Using live-cell imaging, the team tracked neuronal migrations. (
  • Oxidative phosphorylation on the other hand in general favors an anti-inflammatory phenotype such as that of alternatively activated M2 macrophages and regulatory T cells (T reg ). (
  • We observed decreased phosphorylation of 1101 phosphopeptides (1.5-fold) corresponding to 752 proteins upon CAMKK2 inhibition. (
  • Importantly, imatinib and nilotinib increased tyrosine phosphorylation of p130Cas, FAK, PXN and radial spheroid invasion in stem cell lines isolated from human glioma biopsies. (
  • Conclusions: These data suggest that preserving the NO signal through endogenous inhibition of asymmetric dimethylarginine (the endogenous nitric oxide inhibitor) enhances wound repair even in the presence of swine dust exposure. (
  • 12. Impact of Hybrid-polar Histone Deacetylase Inhibitor m-Carboxycinnamic Acid bis-Hydroxyamide on Human Pancreatic Adenocarcinoma Cells. (
  • 20. Discovery of specific HDAC6 inhibitor with anti-metastatic effects in pancreatic cancer cells through virtual screening and biological evaluation. (
  • Treatment of AGS GC cells with a CAMKK2 inhibitor, STO-609, resulted in decreased cell proliferation, cell migration, invasion, colony-forming ability, and G1/S-phase arrest. (
  • Quantitative phosphoproteomics in AGS cells with the CAMKK2 inhibitor led to the identification of 9603 unique phosphosites mapping to 3120 proteins. (
  • Inhibitor studies using antisense and sense oligodeoxynucleotides against mRNAs of iNOS and TNF-alpha, antibodies against adhesion molecules suggested that interactions via CD18 and ICAM-1 leads to activation and mediator production of Kupffer cells cocultured with hepatoma cells. (
  • Inhibition of VEGFR-2 by a specific kinase inhibitor (NVP-AAD777) enhanced the CS-induced oxidative stress, causing augmented inflammatory cell influx and proinflammatory mediators release in mouse lung. (
  • A wound healing assay and a Transwell assay were applied to study cell migration and invasion. (
  • The Cdc42 G-LISA Activation Assay measures the entire level of GTP-loaded Cdc42 protein in cell lysates. (
  • Cell lysates (8, 17, 35 µg) were subjected to the G-LISA assay. (
  • Cell lysates subjected to the G-LISA™ assay and OD was read at 490 nm. (
  • We developed a robust in vivo assay to identify new cell migration inhibitors and conducted a high-throughput screen using transgenic zebrafish and the migrating posterior lateral line primordium as a readout for migratory inhibition. (
  • Wound healing assay and Transwell assay were carried out to access the cell migration and invasion ability. (
  • Finally, it was demonstrated by reverse transcription-quantitative polymerase chain reaction assay and wound healing assay that curcumin could enhance radiosensitization of NPC cell lines via mediating regulation of tumor stem-like cells by the 'hsa_circRNA_102115'-'hsa-miR-335-3p'-'MAPK1' interaction network. (
  • It is also demonstrated that HDAC6 knockdown will affect both proliferation and migration of the SMG cell lines. (
  • In 1995, we established the system which can determine productions of nitric oxide (NO) and TNF-alpha and apoptotic hepatoma cells with fragmented DNA and nuclear alterations. (
  • Rat Kupffer cell-derived nitric oxide suppresses proliferation and induces apoptosis of syngeneic hepatoma cells. (
  • Kupffer cell-mediated mitochondrial dysfunction in hepatoma cells by production of nitric oxide and the involvement of ICAM-1/LFA-1 molecules in their contact :' Int Immunol. (
  • CD18/ICAM-1-dependent nitric oxide production of Kupffer cells as a cause of mitochondrial dysfunction in hepatoma cells : Influence of chronic alcohol feeding. (
  • 1. Histone deacetylase 6 and cytoplasmic linker protein 170 function together to regulate the motility of pancreatic cancer cells. (
  • Dr. Reichert's research interests have included biosensors, protein mediated cell adhesion, wound healing, and biocompatibilty. (
  • Biosensors, protein mediated cell adhesion, and wound healing. (
  • The G-LISA ® series of Small G-Protein Activation Assays are ELISA based assays with which you can measure the GTP form of small G-proteins from lysates of cells or tissues and all in less than 3 h. (
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (
  • T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. (
  • G protein-coupled receptors (GPCR), such as the chemokine receptors, may affect homeostasis by direct signaling or by guiding T cell migration to distinct location-restricted signals. (
  • Homeostatic trophic signals, in turn, may suppress chemokine sensitivity and cytoskeletal remodeling, to inhibit further migration. (
  • Further, a circRNA-miRNA-mRNA interaction network between radiation resistance NPC cell lines and tumor stem cells was constructed by applying bioinformatics. (
  • Metabolic reprogramming of immune cells is essential for both inflammatory as well as anti-inflammatory responses. (
  • Immunologists have recently turned their attention to metabolic changes occurring in immune cells that have a determining role in their effector responses. (
  • A concept is emerging whereby the repolarizing of immune cells towards a less inflamed phenotype by manipulating metabolism using small molecules and metabolic intermediates might be possible. (
  • Through the differential metabolic requirements of effector and regulatory immune cell populations we have a therapeutic opportunity that allows for cellular selectivity when regulating immune responses. (
  • Targeting metabolic processes therapeutically will, unlike the approach of global immunosuppression, specifically and selectively target cells with high metabolic demands whilst not affecting other immune cells hence potentially reducing unwanted side effects. (
  • Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms. (
  • 17. HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin. (
  • Using human plasma samples, tumor tissue, cancer cell lines, and genetically engineered mouse models, the origins of these proteins are being investigated. (
  • This laboratory is also focused on the identification of proteins with expression restricted to the surface of cancer cells which can be used as novel targets for molecular imaging technologies. (
  • Mucin-domain glycoproteins are highly O-glycosylated cell surface and secreted proteins that serve as both biochemical and biophysical modulators. (
  • These findings identify a novel mechanism of action in GBM cells for two well established front line therapies for cancer resulting in enhanced tumour cell motility. (
  • These data suggest a novel mechanism of T cell homeostasis wherein GPCR may promote T cell migration to distinct location-restricted homeostatic trophic cues for T cell survival and growth. (
  • Knockdown of circACTG1 restrained 97H and Huh7 cell migration and invasion. (
  • Furtherly, miR-940-downregulated expression was also found in HCC patients, and importantly, miR-940 inhibition reversed circACTG1 expression in 97H cells with circACTG1 knockdown. (
  • Knockdown of HPV18 E6 significantly inhibited the expression of miR‑130a in HeLa cervical cancer cells. (
  • Furthermore, knockdown of miR‑130a reduced the migration and invasion of HeLa cells. (
  • Furthermore, knockdown of TIMP2 rescued the suppressive effects of miR‑130a downregulation on the migration and invasion of HeLa cells. (
  • 10. Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration. (
  • We screened FDA-approved drugs and other bioactive compounds, as well as a collection of natural products and a set of kinase inhibitors to identify compounds that blocked migration. (
  • We also identified that inhibition by novel flavonoid-derived molecules and a cluster of structurally related kinase inhibitors disrupted primordium migration. (
  • Interactions between primordium cells and their environment determines the self-organization of the zebrafish posterior Lateral Line primordium as it migrates under the skin from the ear to the tip of the tail forming and depositing neuromasts to spearhead formation of the posterior Lateral Line sensory system. (
  • By this time, inflammation was seen to be preceded by cell and tissue injuries, and that vascular changes including leukocyte emigration were secondary events (12,85). (
  • The first physical-chemical analysis of inflammation, cell stress and local tissue changes, promoted by an increasing concentration of oxidants and osmotic pressure, were also made at this time (21). (
  • Here we show that mouse and human SCLC cells in culture and in vivo can grow cellular protrusions that resemble axons. (
  • Re-playing these developmental processes with a patient's own cells can allow us to determine what distinguishes these different disorders at a molecular and cellular level. (
  • 7. HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma. (
  • CD155, which may play a role in cancer cell invasion and migration, binds other molecules including Vitronectin, Nectin-3, DNAM-1/CD226, CD96, and TIGIT but does not bind homotypically (3, 4). (
  • Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. (
  • Investigations using these techniques revealed that coculture of Kupffer cells and hepatoma cells stimulate productions of NO and TNF-alpha, and these mediators released from Kupffer cells synergistically induce apoptosis of hepatoma cells. (
  • 11. Low-calcium serum-free defined medium selects for growth of normal prostatic epithelial stem cells. (
  • Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub. (
  • The function of these channels is to transport calcium ions into cells. (
  • The altered channels stay open much longer than usual, which allows calcium ions to continue flowing into cells abnormally. (
  • Calcium ions are involved in many different functions during development, including cell-to-cell communication and migration. (
  • The case of an adult who developed both hepatic dysfunction and an impaired macrophage migration after exposure to cimetidine is discussed. (
  • Methods: To test this hypothesis, we cultured primary tracheal epithelial cells in monolayers from both wild type and dimethylarginine dimethylaminohydrolase (DDAH) overexpressing C57Bl/6 mice and measured wound repair using the electric cell impedance sensing (ECIS) system. (
  • Importantly, a significant enhancement of wound repair (25% increase in resistance) was observed in DDAH cells vs. wild type cells treated with swine CAFO dust for 24 hr. (
  • Imatinib and nilotinib treatment increased two dimensional cell migration and three dimensional radial spheroid invasion in collagen. (
  • To study prenatal brain development and how such genetic mutations disrupt the process, a team led by Dr. Sergiu Pasca at Stanford University created a miniaturized brain model by directing human stem cells in a dish to become neurons and form 3-D brain organoids or brain-region "spheroids. (
  • Accumulating evidence has substantiated that cancer stem cells (CSCs) or tumor side populations (SP) have self-renewal and stem-like cell properties, and play a crucial role in tumor resistance and relapse to radiotherapy [ 6 ]. (
  • Current studies have shown that curcumin exerts prominent inhibitory effects on various cancer stem cells through different pathways. (
  • It is preferentially expressed on Th17 cells compared to Th2 cells (10), and its activation promotes the development of Th1 responses (11). (
  • These phenotypes are likely driven by changes in gene expression and epigenetic programs that allow cancer cells to overcome the many hurdles that normally constrain the metastatic process. (
  • The loss of complex formation results in inhibition of VEGF signaling and IL-8 gene expression. (
  • Sex determination, as an early embryological event, can help us address basic questions of the regulation of gene expression, cell-fate determination, and hormone signaling. (
  • MicroRNAs (miRs), a class of small non-coding RNAs, can directly bind to the 3′ untranslated region (UTR) of their target mRNAs, and cause RNA degradation or translation inhibition ( 7 , 8 ). (
  • Although there has been declared that circRNAs are heterogeneously expressed in many tumor cells [ 11 ], raising the possibility and potential role of circRNAs in diagnostic and prognosis, the evidence connecting circRNAs and HCC remains a mystery. (
  • The dissolution of this complex leads to increasing E-Cadherin levels at the plasma membrane, resulting in loss of CIL, and inhibition of CNC migration. (
  • 4. Histone deacetylase 3 promotes pancreatic cancer cell proliferation, invasion and increases drug-resistance through histone modification of P27, P53 and Bax. (
  • 16. HDAC6 promotes growth, migration/invasion, and self-renewal of rhabdomyosarcoma. (
  • For instance, HPV16 E7 increases the expression of miR-27b, which further promotes the proliferation and invasion of cervical carcinoma cells via directly suppressing the expression of peroxisome proliferator-activated receptor γ ( 14 ). (
  • Surprisingly, while chemokines did not affect atrophy, atrophic T cells displayed increased chemokine-induced chemotaxis that was prevented by IL-7 and submitogenic anti-CD3 antibody treatment. (
  • Small cell lung cancer (SCLC) is one of the most lethal and most metastatic cancer types. (
  • Although Eph-ephrin signaling has been implicated in the migration of cranial neural crest (CNC) cells, it is still unclear how ephrinB transduces signals affecting this event. (
  • 1 Pro-inflammatory signals will induce a metabolic switch in both myeloid and lymphoid cells, resulting in upregulation of aerobic glycolysis in a manner similar to the Warburg effect described in cancer cells. (
  • Skin biopsy showed eosinophilic spongiosis leading to spongiotic vesicles, perivascular/interstitial inflammatory infiltrates composed of eosinophilic and lymphocytic cells without atypical cells, mostly located in the superficial and mid dermis ( Figure 2 , panels A, B). Grocott methenamine silver stain, Gram stain, and periodic acid-Schiff stain showed no bacterial or fungal element. (
  • Our results indicate that TBC1d24 is a critical player in ephrinB2 control of CNC cell migration via CIL. (
  • More than 90% are adenocarcinomas, and the remainder are squamous cell tumors. (
  • Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors. (

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