Cell Membrane
Membranes
Membrane Lipids
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
Intracellular Membranes
Membrane Potentials
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
Erythrocyte Membrane
Membranes, Artificial
Cell Membrane Permeability
Membrane Fluidity
Basement Membrane
A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.
Lipid Bilayers
Microscopy, Electron
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Membrane Transport Proteins
Protein Transport
Protein Binding
Liposomes
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Erythrocytes
Models, Biological
Mitochondrial Membranes
The two lipoprotein layers in the MITOCHONDRION. The outer membrane encloses the entire mitochondrion and contains channels with TRANSPORT PROTEINS to move molecules and ions in and out of the organelle. The inner membrane folds into cristae and contains many ENZYMES important to cell METABOLISM and energy production (MITOCHONDRIAL ATP SYNTHASE).
Cells, Cultured
Synaptic Membranes
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Hydrogen-Ion Concentration
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Microscopy, Fluorescence
Carrier Proteins
Cell Fractionation
Potassium
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
Cell Membrane Structures
Detergents
Phosphatidylcholines
Electrophoresis, Polyacrylamide Gel
Amino Acid Sequence
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Mutation
Freeze Fracturing
Preparation for electron microscopy of minute replicas of exposed surfaces of the cell which have been ruptured in the frozen state. The specimen is frozen, then cleaved under high vacuum at the same temperature. The exposed surface is shadowed with carbon and platinum and coated with carbon to obtain a carbon replica.
Biological Transport, Active
Microscopy, Confocal
Temperature
Sodium
Endoplasmic Reticulum
A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)
Recombinant Fusion Proteins
Cytoplasm
Golgi Apparatus
A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)
Rabbits
Endocytosis
Binding Sites
Extraembryonic Membranes
The thin layers of tissue that surround the developing embryo. There are four extra-embryonic membranes commonly found in VERTEBRATES, such as REPTILES; BIRDS; and MAMMALS. They are the YOLK SAC, the ALLANTOIS, the AMNION, and the CHORION. These membranes provide protection and means to transport nutrients and wastes.
Fluorescent Dyes
Ion Channels
Subcellular Fractions
Components of a cell produced by various separation techniques which, though they disrupt the delicate anatomy of a cell, preserve the structure and physiology of its functioning constituents for biochemical and ultrastructural analysis. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p163)
Cricetinae
Diffusion
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Models, Molecular
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Cholesterol
Solubility
Cattle
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Adenosine Triphosphate
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Base Sequence
Mitochondria
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Blotting, Western
Octoxynol
Microscopy, Immunoelectron
Transfection
Cytosol
Permeability
Phosphatidylserines
Phosphatidylethanolamines
Protein Structure, Secondary
Sequence Homology, Amino Acid
Receptors, Cell Surface
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
CHO Cells
Exocytosis
Hemolysis
Cytoskeleton
Cloning, Molecular
Membrane Potential, Mitochondrial
Anion Exchange Protein 1, Erythrocyte
A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.
Spectrin
A high molecular weight (220-250 kDa) water-soluble protein which can be extracted from erythrocyte ghosts in low ionic strength buffers. The protein contains no lipids or carbohydrates, is the predominant species of peripheral erythrocyte membrane proteins, and exists as a fibrous coating on the inner, cytoplasmic surface of the membrane.
Green Fluorescent Proteins
Electrophysiology
Purple Membrane
Functionally and structurally differentiated, purple-pigmented regions of the cytoplasmic membrane of some strains of Halobacterium halobium. The membrane develops under anaerobic conditions and is made almost entirely of the purple pigment BACTERIORHODOPSINS. (From Singleton & Sainsbury Dictionary of Microbiology and Molecular Biology, 2d ed)
Microscopy, Electron, Scanning
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
HeLa Cells
Endosomes
Vacuoles
Immunoblotting
Actins
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
Freeze Etching
A replica technique in which cells are frozen to a very low temperature and cracked with a knife blade to expose the interior surfaces of the cells or cell membranes. The cracked cell surfaces are then freeze-dried to expose their constituents. The surfaces are now ready for shadowing to be viewed using an electron microscope. This method differs from freeze-fracturing in that no cryoprotectant is used and, thus, allows for the sublimation of water during the freeze-drying process to etch the surfaces.
COS Cells
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
beta-Cyclodextrins
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Lipids
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Dogs
Epithelium
Nictitating Membrane
Bruch Membrane
The inner layer of CHOROID, also called the lamina basalis choroideae, located adjacent to the RETINAL PIGMENT EPITHELIUM; (RPE) of the EYE. It is a membrane composed of the basement membranes of the choriocapillaris ENDOTHELIUM and that of the RPE. The membrane stops at the OPTIC NERVE, as does the RPE.
Glycoproteins
Immunohistochemistry
Sodium-Potassium-Exchanging ATPase
An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.
Water
Dose-Response Relationship, Drug
GTP-Binding Proteins
Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.
Enzyme Activation
Binding, Competitive
Patch-Clamp Techniques
An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
Structure-Activity Relationship
Sphingomyelins
Guinea Pigs
Cercopithecus aethiops
Kidney
Osmosis
Liver
Complement Membrane Attack Complex
A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.
Hydrophobic and Hydrophilic Interactions
Microscopy, Electron, Transmission
Peptide Fragments
Cell Polarity
Osmotic Fragility
Rats, Sprague-Dawley
Porins
Porins are protein molecules that were originally found in the outer membrane of GRAM-NEGATIVE BACTERIA and that form multi-meric channels for the passive DIFFUSION of WATER; IONS; or other small molecules. Porins are present in bacterial CELL WALLS, as well as in plant, fungal, mammalian and other vertebrate CELL MEMBRANES and MITOCHONDRIAL MEMBRANES.
Microsomes
Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Mathematics
Rats, Inbred Strains
Aquaporins
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Protein Processing, Post-Translational
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
Phosphatidylglycerols
Lysosomes
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Potassium Channels
Neurons
Glycosylphosphatidylinositols
Osmolar Concentration
Transport Vesicles
Magnesium
Tumor Cells, Cultured
Anions
Centrifugation, Density Gradient
Fatty Acids
Protein Sorting Signals
Phosphatidylinositols
Luminescent Proteins
Membrane Proteins
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Ion Transport
Antibodies
Surface Properties
Fluorescence Polarization
Measurement of the polarization of fluorescent light from solutions or microscopic specimens. It is used to provide information concerning molecular size, shape, and conformation, molecular anisotropy, electronic energy transfer, molecular interaction, including dye and coenzyme binding, and the antigen-antibody reaction.
Cytoskeletal Proteins
Macromolecular Substances
Cations
Fetal Membranes, Premature Rupture
Valinomycin
A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies.
Tympanic Membrane
Trypsin
Descemet Membrane
Organelles
Caveolin 1
Antigens, Surface
Fibroblasts
Action Potentials
Plasmids
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Glycosylation
Glycolipids
Extracorporeal Membrane Oxygenation
Models, Chemical
Proton-Translocating ATPases
Filipin
Intercellular Junctions
Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)
Micelles
Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
Diphenylhexatriene
Ouabain
Rats, Wistar
Mutagenesis, Site-Directed
Staining and Labeling
Cell Survival
The structlre of pili (fimbriae) of Moraxella bovis. (1/52017)
Cells from rough and smooth colonies of Moraxella bovis were examined by electron microscopy utilizing both shadowing and thin sectioning techniques. Pili were found on the surfaces of cells from rough but not smooth colonies. Pili had a peritrichoud distribution and appeared as delicate (6.5-8.5 nm in diameter), elongated unbranched filaments. When bacteria were sectioned pili did not contain central pores and appeared to originate from opacities on the surface of the cell wall. (+info)Glycopeptides from the surgace of human neuroblastoma cells. (2/52017)
Glycopeptides suggesting a complex oligosaccharide composition are present on the surface of cells from human neuroblastoma tumors and several cell lines derived from the tumors. The glycopeptides, labeled with radioactive L-fucose, were removed from the cell surface with trypsin, digested with Pronase, and examined by chromatography on Sephadex G-50. Human skin fibroblasts, brain cells, and a fibroblast line derived from neuroblastoma tumor tissue show less complex glycopeptides. Although some differences exist between the cell lines and the primary tumor cells, the similarities between these human tumors and animal tumors examined previously are striking. (+info)The effects of digestive enzymes on characteristics of placental insulin receptor. Comparison of particulate and soluble receptor preparations. (3/52017)
The role of the surrounding membrane structure on the binding characteristics of the insulin receptor was studied by using several digestive enzymes. The effects observed with particulate membrane preparations are compared with those from soluble receptor preparations. beta-Galactosidase and neuraminidase had no effect on insulin binding to either particulate or soluble receptors from human placentae. Exposure to 2 units of phospholipase C/ml increased insulin binding to particulate membranes, but was without effect on the soluble receptor preparation. The increase in binding to particulate membranes was shown to be due to an increase in apparent receptor number. After 5 min exposure to 500 microgram of trypsin/ml there was an increase in insulin binding to the particulate membrane fraction, owing to an increase in receptor affinity. After 15 min exposure to this amount of trypsin, binding decreased, owing to a progressive decrease in receptor availability. In contrast, this concentration of trypsin had no effect on the solubilized receptor preparation. Because of the differential effects of phospholipase C and trypsin on the particulate compared with the solubilized receptor preparations, it is concluded that the effects of these enzymes were due to an effect on the surrounding membrane structure. Changes in receptor configuration due to alterations within the adjoining membrane provide a potential mechanism for mediating short-term alterations in receptor function. (+info)Structural and functional changes in acute liver injury. (4/52017)
Carbon tetrachloride produces liver cell injury in a variety of animal species. The first structurally recognizable changes occur in the endoplasmic reticulum, with alteration in ribosome-membrane interactions. Later there is an increase in intracellular fat, and the formation of tangled nets of the ergastoplasm. At no time are there changes in mitochondria or single membrane limited bodies in cells with intact plasmalemma, although a relative increase in cell sap may appear. In dead cells (those with plasmalemma discontinuties) crystalline deposits of calcium phosphatase may be noted. Functional changes are related to the endoplasmic reticulum and the plasma membrane. An early decrease in protein synthesis takes place; an accumulation of neutral lipid is related to this change. Later alterations in the ergastoplasmic functions (e.g., mixed function oxidation) occurs. Carbon tetrachloride is not the active agent; rather, a product of its metabolism, probably the CC1, free radical, is. The mechanisms of injury include macromolecular adduction and peroxide propagation. A third possibility includes a cascade effect with the production of secondary and tertiary products, also toxic in nature, with the ability to produce more widespread damage to intracellular structures. (+info)Dopamine stimulates salivary duct cells in the cockroach Periplaneta americana. (5/52017)
This study examines whether the salivary duct cells of the cockroach Periplaneta americana can be stimulated by the neurotransmitters dopamine and serotonin. We have carried out digital Ca2+-imaging experiments using the Ca2+-sensitive dye fura-2 and conventional intracellular recordings from isolated salivary glands. Dopamine evokes a slow, almost tonic, and reversible dose-dependent elevation in [Ca2+]i in the duct cells. Upon stimulation with 10(-)6 mol l-1 dopamine, [Ca2+]i rises from 48+/-4 nmol l-1 to 311+/-43 nmol l-1 (mean +/- s.e.m., N=18) within 200-300 s. The dopamine-induced elevation in [Ca2+]i is absent in Ca2+-free saline and is blocked by 10(-)4 mol l-1 La3+, indicating that dopamine induces an influx of Ca2+ across the basolateral membrane of the duct cells. Stimulation with 10(-)6 mol l-1 dopamine causes the basolateral membrane to depolarize from -67+/-1 to -41+/-2 mV (N=10). This depolarization is also blocked by La3+ and is abolished when Na+ in the bath solution is reduced to 10 mmol l-1. Serotonin affects neither [Ca2+]i nor the basolateral membrane potential of the duct cells. These data indicate that the neurotransmitter dopamine, which has previously been shown to stimulate fluid secretion from the glands, also stimulates the salivary duct cells, suggesting that dopamine controls their most probable function, the modification of primary saliva. (+info)Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation. (6/52017)
In COS cells, Ral GDP dissociation stimulator (RalGDS)-induced Ral activation was stimulated by RasG12V or a Rap1/Ras chimera in which the N-terminal region of Rap1 was ligated to the C-terminal region of Ras but not by Rap1G12V or a Ras/Rap1 chimera in which the N-terminal region of Ras was ligated to the C-terminal region of Rap1, although RalGDS interacted with these small GTP-binding proteins. When RasG12V, Ral and the Rap1/Ras chimera were individually expressed in NIH3T3 cells, they localized to the plasma membrane. Rap1Q63E and the Ras/Rap1 chimera were detected in the perinuclear region. When RalGDS was expressed alone, it was abundant in the cytoplasm. When coexpressed with RasG12V or the Rap1/Ras chimera, RalGDS was detected at the plasma membrane, whereas when coexpressed with Rap1Q63E or the Ras/Rap1 chimera, RalGDS was observed in the perinuclear region. RalGDS which was targeted to the plasma membrane by the addition of Ras farnesylation site (RalGDS-CAAX) activated Ral in the absence of RasG12V. Although RalGDS did not stimulate the dissociation of GDP from Ral in the absence of the GTP-bound form of Ras in a reconstitution assay using the liposomes, RalGDS-CAAX could stimulate it without Ras. RasG12V activated Raf-1 when they were coexpressed in Sf9 cells, whereas RasG12V did not affect the RalGDS activity. These results indicate that Ras recruits RalGDS to the plasma membrane and that the translocated RalGDS induces the activation of Ral, but that Rap1 does not activate Ral due to distinct subcellular localization. (+info)Membrane deinsertion of SecA underlying proton motive force-dependent stimulation of protein translocation. (7/52017)
The proton motive force (PMF) renders protein translocation across the Escherichia coli membrane highly efficient, although the underlying mechanism has not been clarified. The membrane insertion and deinsertion of SecA coupled to ATP binding and hydrolysis, respectively, are thought to drive the translocation. We report here that PMF significantly decreases the level of membrane-inserted SecA. The prlA4 mutation of SecY, which causes efficient protein translocation in the absence of PMF, was found to reduce the membrane-inserted SecA irrespective of the presence or absence of PMF. The PMF-dependent decrease in the membrane-inserted SecA caused an increase in the amount of SecA released into the extra-membrane milieu, indicating that PMF deinserts SecA from the membrane. The PMF-dependent deinsertion reduced the amount of SecA required for maximal translocation activity. Neither ATP hydrolysis nor exchange with external SecA was required for the PMF-dependent deinsertion of SecA. These results indicate that the SecA deinsertion is a limiting step of protein translocation and is accelerated by PMF, efficient protein translocation thereby being caused in the presence of PMF. (+info)The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis. (8/52017)
Polarized secretion requires proper targeting of secretory vesicles to specific sites on the plasma membrane. Here we report that the exocyst complex plays a key role in vesicle targeting. Sec15p, an exocyst component, can associate with secretory vesicles and interact specifically with the rab GTPase, Sec4p, in its GTP-bound form. A chain of protein-protein interactions leads from Sec4p and Sec15p on the vesicle, through various subunits of the exocyst, to Sec3p, which marks the sites of exocytosis on the plasma membrane. Sec4p may control the assembly of the exocyst. The exocyst may therefore function as a rab effector system for targeted secretion. (+info)Characterization of apical and basolateral plasma membrane domains derived from cultured rat cholangiocytes<...
Changes in the plasma membrane surface of lymphocytes stimulated in vi by hamdani M. Al, M E. Atkinson et al.
Loss of cytoskeletal support is not sufficient for anoxic plasma membrane disruption in renal cells<...
PLOS ONE: accelerating the publication of peer-reviewed science
Highly purified bile-canalicular vesicles and lateral plasma membranes isolated from rat liver on Nycodenz gradients....
Self-organizing actin patterns shape membrane architecture but not cell mechanics. - The Kennedy Institute of Rheumatology
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Academy of 21st Century Learning: Cell Membranes are Way More Complicated Than You Think - Nazzy Pakpour
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Mapping lymphocyte plasma membrane proteins: a proteomic approach. - The Kennedy Institute of Rheumatology
The T cell receptor resides in small ordered plasma membrane domains that aggregate upon T cell activation
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Direct effect of insulin on the synthesis of specific plasma proteins: Biphasic response of hepatocytes cultured in serum- and...
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Cell motility through plasma membrane blebbing | JCB
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The N-Terminal Juxtamembranous Domain of KCNQ1 Is Critical for Channel Surface Expression | Circulation Research
What are membrane reservoirs? | MBInfo
Cell Membrane Function In Animal Cell And Plant Cell - Idalias Salon
Proteins Membrane Binding and Pore Formation, Buch - ReadRate
Transport across plasma membranes - A-Level Science - Marked by Teachers.com
Light control of plasma membrane recruitment using the Phy-PIF system. - PubMed - NCBI
PLOS ONE: Versatile Membrane Deformation Potential of Activated Pacsin
The economics of neurite outgrowth - The addition of new membrane to growing axons<...
Structural Biochemistry/Membrane Proteins/Membrane Curvature - Wikibooks, open books for an open world
High-Affinity Transport of L-Glutamine by a Plasma Membrane Preparation from Rat Brain - Fingerprint - [email protected]
Animal Cell Membrane : 5 Pictures Of Animal Cell Membrane. Animal Cell Membrane.
SID.ir | DROUGHT-INDUCED CHILLING TOLERANCE IN CUCUMBER INVOLVES MEMBRANE STABILISATION IMPROVED BY ANTIOXIDANT SYSTEM
Modulation of Escherichia coli Cell Membrane by a Monotopic Lipid Glycosyltransferase - an Exploration of Potential Mechanisms
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Functional Consequences of Oxidative Membrane Damage, The Journal of Membrane Biology | 10.1007/s00232-005-0753-8 | DeepDyve
Cell membranes are way more complicated than you think - Nazzy Pakpour | Safe Videos for Kids
The cell. 3. Cell membrane. Atlas of plant and animal histology
Data for membrane mobility of three different proteins...
Proteins that are destined to become associated with the inner surface of the plasma membrane are
How to bake membranes without detergent ? - General Lab Techniques
DC-SIGN cell surface distribution during monocyte-deriv | Open-i
Cell membrane
... damage to cell membrane Cell theory Cytoneme Elasticity of cell membranes Gram-positive bacteria Membrane models Membrane ... plasmatic membrane (Pfeffer, 1900), plasma membrane, cytoplasmic membrane, cell envelope and cell membrane. Some authors who ... It was also inferred that cell membranes were not vital components to all cells. Many refuted the existence of a cell membrane ... Hooke misled the cell membrane theory that all cells contained a hard cell wall since only plant cells could be observed at the ...
Proton-exchange membrane fuel cell
Proton-exchange membrane fuel cells (PEMFC), also known as polymer electrolyte membrane (PEM) fuel cells, are a type of fuel ... Before the invention of PEM fuel cells, existing fuel cell types such as solid-oxide fuel cells were only applied in extreme ... the fuel cell. The membrane must also not allow either gas to pass to the other side of the cell, a problem known as gas ... solar cells, and fuel cells. Within the field of fuel cell research, MOFs are being studied as potential electrolyte materials ...
History of cell membrane theory
In this view, the cell was seen to be enclosed by a thin surface, the plasma membrane, and cell water and solutes such as a ... The lipid nature of the cell membrane was first correctly intuited by Georg Hermann Quincke in 1888, who noted that a cell ... but it was nearly two hundred years before a complete cell membrane theory was developed to explain what separates cells from ... model of the cell membrane by Singer and Nicolson in 1972. According to this model, biological membranes are composed largely ...
Alkaline anion exchange membrane fuel cell
... alkaline membrane fuel cells (AMFCs), hydroxide exchange membrane fuel cells (HEMFCs), or solid alkaline fuel cells (SAFCs) is ... An alkaline anion exchange membrane fuel cell (AAEMFC), also known as anion-exchange membrane fuel cells (AEMFCs), ... Proton Exchange Membrane Alkaline fuel cell Winter, M; Brodd, R. J. (2004). "What are batteries, fuel cells, and ... In alkaline anion exchange membrane fuel cell, aqueous KOH is replaced with a solid polymer electrolyte membrane, that can ...
High Temperature Proton Exchange Membrane fuel cell
Cold storage temperatures below 0 °C are no problem for the fuel cell membrane in contrast to DMFC and LT-PEM fuel cell. ... The HT-PEM fuel cell technology is similar to Phosphoric Acid Fuel Cell (PAFC), but mainly differs in the membrane which is ... Whereas the common PEM fuel cell, also called Low Temperature Proton Exchange Membrane fuel cell (LT-PEM), must usually be ... HT-PEM fuel cell was developed in 1995 for operation at higher cell temperatures aiming at lower sensitivity of PEM fuel cells ...
Elasticity of cell membranes
A cell membrane defines a boundary between a cell and its environment. The primary constituent of a membrane is a phospholipid ... A cell membrane is simplified as lipid bilayer plus membrane skeleton. The skeleton is a cross-linking protein network and ... Physics of Composite Cell Membrane and Actin Based Cytoskeleton, in Physics of bio-molecules and cells, Edited by H. Flyvbjerg ... Assume that each proteins in the membrane skeleton have similar length which is much smaller than the whole size of the cell ...
Membrane potential
... glial cells (e.g. astrocytes), mechanoreceptor cells (e.g. hair cells and Merkel cells), chemoreceptor cells (e.g. glomus cells ... juxtaglomerular cells, interstitial cells of Cajal, many types of epithelial cells (e.g. beta cells, alpha cells, delta cells, ... This term is used for the membrane potential of non-excitable cells, but also for the membrane potential of excitable cells in ... Excitable cells include neurons, muscle cells, and some secretory cells in glands. Even in other types of cells, however, the ...
Basement membrane
The basement membrane is a thin, pliable sheet-like type of extracellular matrix that provides cell and tissue support and acts ... Fractones may be a type of basement membrane, serving as a niche for stem cells. Some diseases result from a poorly functioning ... 2005). Basement membranes: cell and molecular biology. Gulf Professional Publishing. ISBN 978-0-12-153356-4. (CS1: long volume ... This is achieved by cell-matrix adhesions through substrate adhesion molecules (SAMs). The basement membrane acts as a ...
Membrane fluidity
In biology, membrane fluidity refers to the viscosity of the lipid bilayer of a cell membrane or a synthetic lipid membrane. ... Membrane fluidity is also affected by cholesterol. Cholesterol can make the cell membrane fluid as well as rigid. Membrane ... Lateral diffusion (within the membrane matrix) of membrane-related enzymes can affect reaction rates. Consequently, membrane- ... is hypothesized to exist in cell membranes and perform biological functions. Also, a narrow annular lipid shell of membrane ...
Membrane lipid
Cell membranes require high levels of cholesterol - typically an average of 20% cholesterol in the whole membrane, increasing ... The bilayer formed by membrane lipids serves as a containment unit of a living cell. Membrane lipids also form a matrix in ... Cholesterol also occurs naturally in other eukaryote cell membranes. Sterols have a hydrophobic four-membered fused ring rigid ... Wikimedia Commons has media related to Membrane lipids. Membrane+lipids at the US National Library of Medicine Medical Subject ...
Membrane progesterone receptor
... s (mPRs) are a group of cell surface receptors and membrane steroid receptors belonging to the ... membrane progesterone receptors are good candidates for the membrane receptors mediating many of the nonclassical cell surface- ... Immunohistochemical studies revealed that mPRγ is associated with the apical membrane of ciliated cells in the lumen of the ... This determines its location in the cell, the membrane. MPRs recognise some specific substances and facilitate the entrance of ...
Semipermeable membrane
Information can also pass through the plasma membrane when signaling molecules bind to receptors in the cell membrane. The ... Other types of semipermeable membranes are cation-exchange membranes (CEMs), anion-exchange membranes (AEMs), alkali anion ... "Semipermeable Membranes' Role in Cell Communication - Video & Lesson Transcript". Study.com. Retrieved 6 April 2017. Wood, ... Semipermeable membrane is a type of biological or synthetic, polymeric membrane that will allow certain molecules or ions to ...
Tectorial membrane
When tectorial membrane calcium is restored, sensory cell function returns.[1] Floor of ductus cochlearis. Cross section of the ... The tectoria membrane (TM) is one of two acellular membranes in the cochlea of the inner ear, the other being the basilar ... It overlies the sensory inner hair cells and electrically-motile outer hair cells of the organ of Corti and during acoustic ... Meaud, Julien; Grosh, Karl (2010). "The effect of tectorial membrane and basilar membrane longitudinal coupling in cochlear ...
Membrane protein
Integral membrane proteins are a permanent part of a cell membrane and can either penetrate the membrane (transmembrane) or ... Peripheral membrane proteins are transiently associated with the cell membrane. Membrane proteins are common, and medically ... Membrane proteins are common proteins that are part of, or interact with, biological membranes. Membrane proteins fall into ... Look up membrane protein in Wiktionary, the free dictionary. Wikimedia Commons has media related to Membrane proteins. Membrane ...
Plasma membrane Ca2+ ATPase
The plasma membrane Ca2+ ATPase (PMCA) is a transport protein in the plasma membrane of cells and functions to remove calcium ( ... PMCAs were first discovered in the 1960s in the membranes of red blood cells. The presence of an ATPase was discovered in the ... PMCA was first purified from red blood cell membranes in 1979. Jensen, Thomas P.; Buckby, Lucy E.; Empson, Ruth M. (2004). " ... In breast tissue, mammary epithelial cells express PMCA2, which transports calcium across the apical surface of the cells into ...
Basilar membrane
The hair cells are attached to the basilar membrane, and with the moving of the basilar membrane, the tectorial membrane and ... In the membrane of the outer hair cells there are motor proteins associated with the membrane. Those proteins are activated by ... The basilar membrane is also the base for the hair cells. This function is present in all land vertebrates. Due to its location ... This leads to the hair cell have a resting potential of -45 mV. As the basilar membrane moves upward, the cilia move in the ...
Subthreshold membrane potential oscillations
This technique incorporates electrical stimulation of polar molecules in cell membrane. The study found that Dorsal cells are ... ions must enter the cell through voltage gated sodium channels through membrane and depolarize the cell. The threshold is ... They used whole-cell patch recording in vivo and biophysical modeling in compartmental simulations of entorhinal stellate cells ... Subthreshold membrane potential oscillations are membrane oscillations that do not directly trigger an action potential since ...
Bacterial outer membrane vesicles
An inner bilayer, the inner cell membrane, encloses the cytoplasm or cytosol. Surrounding this inner cell membrane there is a ... In addition, there is a firm cell wall consisting of peptidoglycan layer, which surrounds the cell membrane and occupies the ... Antibiotic treatment altered vesicle dynamics, vesicle-to-membrane affinity, and surface properties of the cell membranes, ... Bacterial membrane vesicles dispersion along the cell surface was measured in live Escherichia coli, commensal bacteria common ...
Mitochondria associated membranes
The mitochondria-associated ER membranes (MAMs), play role in cell death modulation. Mitochondrial outer membrane ... These closed membranes are double membrane-bond, with lysosomes inside it. The main function of these membrane is degradation, ... Eiyama, Akinori; Okamoto, Koji (2015). "PINK1/Parkin-mediated mitophagy in mammalian cells". Current Opinion in Cell Biology. ... Mitochondria-associated membranes) in mammalian cells: Lipids and beyond". Biochimica et Biophysica Acta (BBA) - Molecular and ...
Membrane glycoproteins
... are membrane proteins which play important roles in cell recognition. Examples include: Fibronectin ... Membrane glycoproteins, Glycoproteins, All stub articles, Membrane protein stubs). ... Laminin Osteonectin Glycocalyx Media related to Membrane glycoproteins at Wikimedia Commons Membrane+glycoproteins at the US ...
Membrane reactor
In biological systems, membranes fulfill a number of essential functions. The compartmentalization of biological cells is ... Chemical reactors making use of membranes are usually referred to as membrane reactors. The membrane can be used for different ... A membrane reactor is a physical device that combines a chemical conversion process with a membrane separation process to add ... For dense membranes the separation is governed by the difference of the chemical potential of the components in the membrane. ...
Proton-exchange membrane
The primary application of proton-exchange membranes is in PEM fuel cells. These fuel cells have a wide variety of commercial ... A proton-exchange membrane, or polymer-electrolyte membrane (PEM), is a semipermeable membrane generally made from ionomers and ... of a proton-exchange membrane fuel cell or of a proton-exchange membrane electrolyser: separation of reactants and transport of ... PEM fuel cells use a solid polymer membrane (a thin plastic film) which is permeable to protons when it is saturated with water ...
Membrane transport
The cell membrane regulates the transport of materials entering and exiting the cell. Thermodynamically the flow of substances ... In this system a semipermeable membrane separates two solutions of different concentration of the same solute. If the membrane ... The movements of most solutes through the membrane are mediated by membrane transport proteins which are specialized to varying ... The regulation of passage through the membrane is due to selective membrane permeability - a characteristic of biological ...
Membrane bound polyribosome
In cell biology, membrane bound polyribosomes are attached to a cell's endoplasmic reticulum. When certain proteins are ... Bound ribosomes usually produce proteins that are used within the cell membrane or are expelled from the cell via exocytosis. ... v t e (Cell biology, All stub articles, Cell biology stubs). ... "The Fate of Membrane-bound Ribosomes Following the Termination ... synthesized by a ribosome they can become "membrane-bound". The newly produced polypeptide chains are inserted directly into ...
Milk fat globule membrane
During myelination, nerve axons are wrapped with multiple layers of cell membrane by oligodendrocyte glial cells, a process ... In the next stage, lipid droplets then migrate to the apical surface of the cell, where plasma membrane subsequently envelops ... and lipids derived primarily from the membrane of the secreting mammary epithelial cell (lactocyte). This trilayer is ... almost half of identified proteins have membrane/protein trafficking or cell signaling functions. The glycosylated proteins, ...
Biological membrane
A biological membrane, biomembrane or cell membrane is a selectively permeable membrane that separates the interior of a cell ... The cell membranes are different from the isolating tissues formed by layers of cells, such as mucous membranes, basement ... and the cell membrane separates a cell from its surrounding medium. Peroxisomes are one form of vacuole found in the cell that ... For all cells, membrane fluidity is important for many reasons. It enables membrane proteins to diffuse rapidly in the plane of ...
Chlorine production
Too strong or too weak a solution may damage the membranes. Membrane cells typically produce caustic in the range of 30% to 33 ... the Hargreaves-Bird cell (1901), the Gibbs cell (1908), and the Townsend cell (1904). The cells vary in construction and ... The building that houses the many electrolytic cells is usually called a cell room or cell house, although some plants are ... The electrolysis cell is divided into two "sections" by a cation permeable membrane acting as a cation exchanger. Saturated ...
Fences and pickets model of plasma membrane structure
The fences and pickets model of plasma membrane is a concept of cell membrane structure suggesting that the fluid plasma ... Kusumi A, Sako Y (August 1996). "Cell surface organization by the membrane skeleton". Current Opinion in Cell Biology. 8 (4): ... "Three-dimensional reconstruction of the membrane skeleton at the plasma membrane interface by electron tomography". J. Cell ... meshwork is directly situated on the cytoplasmic surface of the plasma membrane. Membrane skeleton fence, or membrane skeleton ...
Plasmodium falciparum erythrocyte membrane protein 1
... from the intraerythrocytic asexual parasite to the cytoplasmic face of the host cell membrane". The Journal of Cell Biology. ... The last CIDR region joins the TMD, which is embedded in the cell membrane. The TMD and ATS are highly conserved among ... It was discovered in 1984 when it was reported that infected RBCs had unusually large-sized cell membrane proteins, and these ... Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a family of proteins present on the membrane surface of red ...
Jens Christian Skou
Boldyrev, A. A. (2000). "Na+,K+-ATPase: 40 years of investigations". Membrane & Cell Biology. 13 (6): 715-9. PMID 10963431. ... He therefore had the idea of looking at an enzyme which was embedded in the membrane and finding out if its properties were ... Post had recently discovered that three sodium ions were pumped out of the cell for every two potassium ions pumped in, and in ... Skou, J. C. (1989). "The identification of the sodium-pump as the membrane-bound Na+/K+-ATPase: a commentary on 'The Influence ...
Camelpox
The newly formed virus particles can be released during cell lysis, or they can derive a host cell produced membrane and be ... After the virus attaches to a host cell, it injects its viral core (the shell containing its DNA) into the cell's cytoplasm. ...
Paul Mischel
"Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling". Cell ... Zimmer, Carl (2019-11-20). "Scientists Are Just Beginning to Understand Mysterious DNA Circles Common in Cancer Cells". The New ... Williams, Ruth (2008-06-30). "Paul Mischel: All about brains". The Journal of Cell Biology. 181 (7): 1044-1045. doi:10.1083/jcb ... Molecular Cell. 67 (1): 128-138.e7. doi:10.1016/j.molcel.2017.05.030. ISSN 1097-4164. PMC 5521991. PMID 28648777. Guo, Deliang ...
Atrioventricular node
Contraction of heart muscle cells requires depolarization and repolarization of their cell membranes. Movement of ions across ... cell membranes causes these events. The cardiac conduction system (and AV node part of it) coordinates myocyte mechanical ... Bone morphogenetic protein (BMP) cell signaling plays a key role in diverse aspects of cardiac differentiation and ...
Janet Plowe
Janet Quentin Plowe was a biologist credited for helping to discover the cell membrane. In 1931 she demonstrated that the cell ... and the cell membrane itself. Plowe, Janet Quentin (1922). The reduction divisions in the pollen mother-cell of a hybrid cotton ... Plowe, Janet Q. (1931). "Membranes in the plant cell". Protoplasma. 12 (1): 196-220. doi:10.1007/BF01618716. ISSN 0033-183X. ... Plowe, Janet Quentin (1930). Membranes in the plant cell (Ph.D.). University of Pennsylvania. OCLC 1049423562. Collander, Runar ...
Phage display
"CAR T Cells: Engineering Patients' Immune Cells to Treat Their Cancers". National Cancer Institute. 2013-12-06. Retrieved 9 ... Ff phages for phage display is that they require the protein of interest to be translocated across the bacterial inner membrane ... The phage gene and insert DNA hybrid is then inserted (a process known as "transduction") into E. coli bacterial cells such as ... These are made into synthetic receptors for T-Cells collected from the patient that are used to combat the disease. Competing ...
Jesse Francis McClendon
... life processes of cell membranes, the importance of pH control, the role of iodine in human health, and specifically its ...
Prostaglandin-endoperoxide synthase 2
PTGS (COX, which can be confused with "cytochrome oxidase") enzymes are monotopic membrane proteins; the membrane-binding ... Cell Dev. Biol. 17 (5): 544-54. doi:10.1016/j.semcdb.2006.09.001. PMID 17071117. Minghetti L, Pocchiari M (2007). " ... Picot D, Loll PJ, Garavito RM (January 1994). "The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1 ... Increased expression of the PTGS2 gene in the fetal membranes is connected to the presence of inflammation, causing uterine ...
Development of the reproductive system
Development proceeds and the oogonia become fully surrounded by a layer of connective tissue cells (pre-granulosa cells). In ... the ventral part of the cloacal membrane becomes the urogenital membrane. Mesoderm extends to the midventral line for some ... At about the fifth or sixth month the lumen of the vagina is produced by the breaking down of the central cells of the ... For a time the vagina is represented by a solid rod of epithelial cells. A ring-like outgrowth of this epithelium occurs at the ...
Traube cell
The ability of the Traube cell membrane to allow water to flow in while retaining the cell solute is comparable to living cells ... The membrane is semi-permeable, and expands rapidly into the Traube cell. Within the cell is a high concentration of potassium ... When the expansion caused the membrane to burst, a new membrane was quickly formed. In this way, the cell could "grow" and ... A Traube cell is an "artificial cell" created by Moritz Traube in order to study the processes of living cells, including ...
Proto-oncogene tyrosine-protein kinase Src
Lyn and Fgr are highly expressed in malignant prostate cells compared to normal prostate cells. When the primary prostate cells ... Kaplan JM, Varmus HE, Bishop JM (March 1990). "The src protein contains multiple domains for specific attachment to membranes ... HSP90 inhibitor NVP-BEP800 has been described to affect stability of Src tyrosine kinase and growth of T-cell and B-cell acute ... Src, Fyn and Yes are expressed ubiquitously in all cell types while the others are generally found in hematopoietic cells. c- ...
Kir2.6
... maintain resting membrane potential in excitable cells and aid in repolarization of cells following depolarization. Kir2.6 is ... Cell. 140 (1): 88-98. doi:10.1016/j.cell.2009.12.024. PMC 2885139. PMID 20074522. v t e This article incorporates text from the ... Membrane protein stubs, Wikipedia articles incorporating text from the United States National Library of Medicine, Ion channels ...
Rhomboid-related protein 2
The protein encoded by this gene is a member of the rhomboid protease family of integral membrane proteins. This family ... Molecular Cell. 11 (6): 1425-34. doi:10.1016/s1097-2765(03)00181-3. PMID 12820957. Urban S, Lee JR, Freeman M (October 2001). " ... RHBDL2 functions as a sheddase and is localized to the plasma membrane. Known substrates of RHBDL2 include thrombomodulin and ... "Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it ...
Choriogenesis
In developmental biology, choriogenesis is the formation of the chorion, an outer membrane of the placenta that eventually ... April 1993). "Induction of choriogenesis by 20-hydroxyecdysone in the German cockroach". Tissue & Cell. 25 (2): 195-204. doi: ...
Coronavirus nucleocapsid protein
Coronaviruses manipulate the cell cycle of the host cell through various mechanisms. In several coronaviruses, including SARS- ... In addition to its interactions with RNA, N forms protein-protein interactions with the coronavirus membrane protein (M) during ... N also has additional functions in manipulating the cell cycle of the host cell. The N protein is highly immunogenic and ... "Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals". Cell. 181 (7 ...
Methylocella silvestris
... but contain a vesicular membrane system connected to the cytoplasmic membrane. BL2T (=DSM 15510T=NCIMB 13906T) is the type ... Microbial Cell Factories. 19 (1): 144. doi:10.1186/s12934-020-01395-0. ISSN 1475-2859. PMC 7364539. PMID 32677952. Vos PW, ... It lacks intracytoplasmic membranes common to all methane-oxidizing bacteria except Methylocella, ...
Prokaryotic DNA replication
All cells must finish DNA replication before they can proceed for cell division. Media conditions that support fast growth in ... and reactivation of DnaA by the lipid membrane. Once priming is complete, DNA polymerase III holoenzyme is loaded into the DNA ... it is possible that in fast growth conditions the grandmother cells starts replicating its DNA for grand daughter cell. For the ... They bind to DnaA-ADP and DnaA-ATP with equal affinities and are bound by DnaA throughout most of the cell cycle and forms a ...
Papillary carcinomas of the breast
... the presence and location of myoepithelial cells, i.e. cells that normally rest on the basement membrane of mammary gland ducts ... These cells, which are not myoepithelial cells, have been termed globoid cells. They have eosinophilic cytoplasm (i.e. pink or ... Epithelial cells lining the fronds' inner surfaces commonly form solid, cribriform (i.e. large nests of cells perforated by ... Mucin may also occur outside of cells in these lesions. The presence of signet ring-shaped cells bearing mucin-containing ...
Neodymium
J Cell Biol 4:475-478 Hosogi N, Nishioka H, Nakakoshi M (2015) Evaluation of lanthanide salts as alternative stains to uranyl ... Neodymium dust and salts are very irritating to the eyes and mucous membranes, and moderately irritating to skin. Breathing the ... and fuel cells. Among these technologies, permanent magnets are often used to fabricate high-efficiency motors, with neodymium- ... and fuel cell vehicles (FCVs) (hereinafter referred to as xEVs), wind turbines, home appliances, computers, and many small ...
Membrane (disambiguation)
... a triangular membrane occurring in eyes Cell membranes: Plasma membrane, a membrane that separates the interior of all cells ... a smooth membrane consisting of a thin layer of cells, which secrete serous fluid Tunic membrane, protective membrane covering ... Biology: Isolating tissues formed by layers of cells Amnion, a membrane in the amniotic sac Basement membrane, a thin sheet of ... flexible surface Membrane structure, a sort of spatial structure made of tensioned membranes Membrane (M-Theory), a spatially ...
CLINT1
2004). "Clathrin adaptor epsinR is required for retrograde sorting on early endosomal membranes". Dev. Cell. 6 (4): 525-38. doi ... and other proteins to be endocytosed or taken up across neuronal membranes and across the membranes of other types of cells. ... Cell. 14 (2): 625-41. doi:10.1091/mbc.E02-09-0552. PMC 149997. PMID 12589059. Wasiak S, Denisov AY, Han Z, et al. (2004). " ... Cell. 13 (11): 4060-73. doi:10.1091/mbc.E02-03-0171. PMC 133614. PMID 12429846. Pimm J, McQuillin A, Thirumalai S, Lawrence J, ...
Halobacterium salinarum
The membrane consists of a single lipid bilayer surrounded by an S-layer. The S-layer is made of a cell-surface glycoprotein ... pigment present within the membrane of H. salinarum. The primary role of bacterioruberin in the cell is to protect against DNA ... It is able to protect the cell from reactive oxygen species produced from exposure to UV by acting as a target. The ... These proteins form a lattice in the membrane. Sulfate residues are abundant on the glycan chains of the glycoprotein, giving ...
Nigel Unwin
Journal of Cell Biology 93:63-75 Unwin P N T, Zampighi G (1980), "Structure of the junction between communicating cells" Nature ... "Three-dimensional model of purple membrane obtained by electron microscopy" Nature 257:28-32 Unwin P N T, Henderson R (1975), " ... He is currently also Emeritus Professor of Cell Biology at the Scripps Research Institute. Nigel Unwin was born in New Zealand ... He was Professor of Cell Biology at Stanford University from 1980 to 1987. In 1988 he returned to the MRC Laboratory of ...
SLC2A13
v t e v t e (Genes on human chromosome 12, Solute carrier family, All stub articles, Human chromosome 12 gene stubs, Membrane ... BMC Cell Biology. 10: 54. doi:10.1186/1471-2121-10-54. PMC 2717050. PMID 19607714. Satake W, Nakabayashi Y, Mizuta I, Hirota Y ... "Identification of genes associated with non-small-cell lung cancer promotion and progression". Lung Cancer. 67 (2): 151-9. doi: ...
LILRA3
... and dendritic cells involved in antigen processing". The Journal of Experimental Medicine. 185 (10): 1743-51. doi:10.1084/jem. ... the LILRA3 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and ... "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells ... "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for ...
Total base number
A conductivity cell is placed in the titration vessel. The sample solution is titrated with alcoholic hydrochloric acid. Mid- ... This causes an ion exchange in the outer solvated layer at the glass membrane, so a change in potential is generated which can ...
Papillary tumors of the pineal region
The cells of this tumor usually show a columnar to cuboidal cytoplasm with a well-defined cytoplasmic membrane. Vacuolated, or ... If the abnormal cells continue to grow, divide, and produce more abnormal cells, the mass of abnormal cells may eventually ... The papilla is meant to be surface cells. The ependymal cells line the inside of the ventricles of the brain. These cells have ... There are meant to be certain cells in a specific area, for the pineal region these are ependymal cells, and the cells divide ...
The Immunity Syndrome (Star Trek: The Original Series)
The bomb is fired into the cell's nucleus and the Enterprise backs out using what little power remains. With seconds remaining ... Spock pilots a shuttle through the creature's outer membrane and makes his way toward the nucleus. Eventually, he reports that ... With power levels nearly exhausted, the ship approaches the outer membrane just as the bomb explodes. Both the Enterprise and ...
SGCA
The Journal of Cell Biology. 148 (4): 801-10. doi:10.1083/jcb.148.4.801. PMC 2169361. PMID 10684260. Kawai H, Akaike M, Endo T ... comprises a group of proteins that are critical to the stability of muscle fiber membranes and to the linking of the actin ... The Journal of Cell Biology. 143 (7): 2033-44. doi:10.1083/jcb.143.7.2033. PMC 2175228. PMID 9864373. Bowe MA, Mendis DB, ... The Journal of Cell Biology. 148 (4): 801-10. doi:10.1083/jcb.148.4.801. PMC 2169361. PMID 10684260. Yoshida M, Hama H, ...
Metabolism
Proteins are also important in cell signaling, immune responses, cell adhesion, active transport across membranes, and the cell ... Their main structural uses are as part of biological membranes both internal and external, such as the cell membrane. Their ... Electrolytes enter and leave cells through proteins in the cell membrane called ion channels. For example, muscle contraction ... doi:10.1016/j.cell.2016.12.039. PMC 5329766. PMID 28187287. Cooper GM (2000). "The Molecular Composition of Cells". The Cell: A ...
WIPI2
... mRNA is readily detectable in several commonly used laboratory cell lines (HEK293A, HeLa, A431) and several cancer cell ... "Entrez Gene: WIPI2 WD repeat domain, phosphoinositide interacting 2". Orsi A, Polson HE, Tooze SA (December 2009). "Membrane ... which is a lysosomal degradation pathway required for maintaining cell health, surviving periods of nutrient deprivation and ... lines, while WIPI1 expression is limited to cancer cells[citation needed] (but is also detected in many human tissues). The Atg ...
Peer Review of Biology4Kids.com: Cell Structure: Membrane Proteins
This page is a subset of reference material about cell structures. It gives an overview of membrane proteins, with particular ... The user will learn about membrane proteins, their structures, and how they contribute towards cell function. ... There are no prerequisites for this site, although some knowledge of cell structure and function will enhance the learning ... Peer Review: Biology4Kids.com: Cell Structure: Membrane Proteins Peer Review. Biology4Kids.com: Cell Structure: Membrane ...
in the absence of the capacity to dissolve membranes, cancer cells just build battering rams and bash their way around
Membrane Structure - Molecular Biology of the Cell - NCBI Bookshelf
... to activate the pumping of protons across the plasma membrane. (Adapted from H. Luecke et al., Science 286:255-260, 1999.) ... Special proteins inserted in cellular membranes create pores that permit the passage of molecules across them. The bacterial ... Cell membranes are crucial to the life of the cell. The plasma membrane encloses the cell, defines its boundaries, and ... Three views of a cell membrane. (A) An electron micrograph of a plasma membrane (of a human red blood cell) seen in cross ...
In vitro membrane growth for synthetic cell division (MEP)
... What and Why One of the key challenges in the construction of a ... synthetic cell is to realize cell division. The physical process of dividing a single cell into two daughter cells has been a ... You will compare external addition of membrane material with intracellular biosynthesis of the membrane building blocks, called ... In this project, you will explore various techniques for in vitro realization of membrane growth. ...
What Would Happen If There Was No Cell Membrane?
The cell membrane is essential to the life of the cell and without it, the cell dies. If all the cells in an organism suddenly ... The cell membrane provides several vital functions for the cell. Cell walls anchor the cytoplasm and hold the cells shape. It ... the cell wall attaches to the cell walls of other cells to form tissues, organs and ultimately the organism. The cell membrane ... Cells absorb nutrients through the cell membrane and expel waste through the same membrane using both active and passive ...
Browsing by Subject "Cell Membrane"
Opioid Drug Tolerance Linked to Cell Membrane Cholesterol Gene and Key GPCR
Home Topics Drug Discovery Opioid Drug Tolerance Linked to Cell Membrane Cholesterol Gene and Key GPCR ... The worm genetics revealed PTCHD1 plays a key role, altering cholesterol in cell membranes. [Photo by Scott Wiseman for UF ... Ptchd1 belongs to a family of genes known to be involved in regulating cholesterol accumulation in cell membranes. For that ... This discovery then raised a new and important question: Could enriching cholesterol in the cell membrane be a strategy for ...
Scientists Develop New Process to Create Artificial Cell Membranes
... By Eric Sauter. The membranes surrounding and inside cells ... "Layer-by-layer membrane assembly allows us to create synthetic cells with membranes of arbitrary complexity at the molecular ... Scientists Develop New Process to Create Artificial Cell Membranes Researchers Shed Light on Bodys Master Energy Regulator ... The study, "Layer-by-layer Cell Membrane Assembly," was supported by a National Institutes of Health Pathway to Independence ...
Free Biology Flashcards about CellMembrane &Homeo
Study free Biology flashcards about CellMembrane &Homeo created by nicole.strickland to improve your grades. Matching game, ... CellMembrane &Homeo. Plasma membrane. Question. Answer. The function of this organelle is to maintain homeostasis? plasma ... This characteristic allows certain molecules to come in and out of the cell?. selectively permeable ...
Cell Membrane | Difference Between
Modular Membrane Cell Electrolysers | INEOS Electrochemical Solutions
Modular Membrane Cell Electrolysers utilise chlorine and hydrogen from brine in a modern and efficient membrane cell ... Modular Membrane Cell Electrolysers. Learn how chlorine and hydrogen are produced from brine in a modern and efficient membrane ... Membrane cell electrolysers feature a sealed module that consist of two chambers, separated by a flexible cation exchange ... full wetting the membrane in the centre of the cell, for inherently safer operation : ...
Fluid mosaic model of cell membranes (video) | Khan Academy
... if this is a cell right over here, and this is its membrane, its kind of what keeps the cell, the inside of the cell, ... This movement helps the cell membrane maintain its role as a barrier between the inside and outside of the cell environments. ... its going to sit outside of the cell. And these chains of sugars, these are actually key for cell-cell recognition. Your ... Now, why is it called the Fluid Mosaic Model? Well, if we were to look at a cell membrane and just to be clear what were ...
Focused ultrasound helps exogenous genes permeate targeted cells' outer membrane
CONTEXT: National Institutes of Health researchers have successfully broken through the cell membrane, a barrier that has ... Focused ultrasound helps exogenous genes permeate targeted cells outer membrane. .social-ris-container { display: flex; ... Ultrasonic waves were delivered in short pulses to dissipate heat and generate mechanical power that increased a tumor cells ... IMAGES: Stained histologic sections reveal the nuclei of tumor cells in blue as seen with fluorescence microscopy. Green ...
Spatially-resolved eigenmode decomposition of red blood cells membrane fluctuations questions the role of ATP in flickering
... resulting notably in cell membrane fluctuations (CMF). These CMF have been subject of many studies in order to obtain a better ... Red blood cells (RBCs) present unique reversible shape deformability, essential for both function and survival, ... Spatially-resolved eigenmode decomposition of red blood cells membrane fluctuations questions the role of ATP in flickering ... resulting notably in cell membrane fluctuations (CMF). These CMF have been subject of many studies in order to obtain a better ...
Blood bank storage of red blood cells increases RBC cytoplasmic membrane order and bending rigidity | PLOS ONE
Red blood cells (RBCs) are known to undergo compositional changes during storage, which may impact the cells function and ... We extracted the RBCs cytoplasmic membrane (RBCcm) to study the effect of storage on the membranes molecular structure and ... leading to an increased membrane thickness and membrane order. The size of both, lo and liquid disordered (ld) lipid domains ... The results show that the membrane composition has a small contribution to the increased bending rigidity and suggests ...
Graphene shows potential for modelling cell membrane systems
... the lipid bilayer is the fundamental structure of cell membranes, and the structure and dynamic of bilayer membranes govern the ... Graphene could play an important role in the modelling of cell membranes. For example, ... transport of materials and information in and out of cells. ... Graphene shows potential for modelling cell membrane systems. ( ... and its derivatives could be a new cell membrane model system for the researche on fundamental processes in cell membrane ...
Amniotic Membrane - Stem Cell Institute Panama
Tag: amniotic membrane. Neil Riordan PhD - on opening a stem cell clinic in the United States. Stem Cell Pioneers featured Dr. ... Neil Riordan PhD on stem cell expansion in stem cell therapy. Stem Cell Pioneers featured Dr. Riordan in its February ... a monthly segment that features stem cell scientists and doctors answering questions from readers about stem cell therapy. Over ... a monthly segment that features stem cell scientists and doctors answering questions from readers about stem cell therapy. Over ...
Role of Calcineurin Signaling in Membrane Potential-Regulated Maturation of Cerebellar Granule Cells | Journal of Neuroscience
... and membrane resistances (Rm) of granule cells at four stages are indicated. The resting membrane potential and membrane ... Resting membrane potential (C), membrane resistance (Rm) (D), and action potentials (E) of granule cells at DIV 10-14 were ... After a whole-cell configuration had been established, cell membrane capacitance was electronically compensated. The resting ... PCL, Purkinje cell layer. E, Time-dependent changes in a cell population of four developmental stages of granule cells in ...
Promega CytoTox-ONE Homogeneous Membrane Integrity Assay 1000 to 4000 assays:Cell
| Fisher Scientific
CytoTox-ONE Homogeneous Membrane Integrity Assay Shop Promega CytoTox-ONE™ Homogeneous Membrane Integrity Assay at ... Cytotoxicity determination, total cell number determination, measures release of Lactate Dehydrogenase. Description. CytoTox- ... A fast homogeneous, fluorometric method for estimating the number of non-viable cells present in multiwell plates. Based on ... A Fluorometric Method for Estimating the Number of Nonviable Cells Present in Multiwell Plates ...
Cell Membrane Archives - ARTICLESFLY
Prof. Gyorgy Panyi, MD, PhD: 'Membrane cholesterol content and ion channel functions in T cells'
Gyorgy Panyi, MD, PhD: "Membrane cholesterol content and ion channel functions in T cells". ... Lorenzo Moretta, MD "NK cells: from surface receptors to the cure of high risk leukemias" und Prof. Anna Erdei, PhD "Modulation ... Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells. Proceedings of ... Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells. Molecular ...
Living cell membranes can self-sort their components by 'demixing' | UW News
... artificial membranes created in a lab and membranes shed from cells under severe stress. ... Living cell membranes can self-sort their components by demixing. News releases , Research , Science ... Living cell membranes can self-sort their components by demixing UW News staff ... Cells - the building blocks of our bodies - are encapsulated by membranes. The same goes for the specialized compartments ...
Proton exchange membrane fuel cells 9. Vol.1
SCOP 1.67: Class f: Membrane and cell surface proteins and peptides
More info for Class f: Membrane and cell surface proteins and peptides. Timeline for Class f: Membrane and cell surface ... Class f: Membrane and cell surface proteins and peptides appears in SCOP 1.65. *Class f: Membrane and cell surface proteins and ... Lineage for Class f: Membrane and cell surface proteins and peptides. *Root: SCOP 1.67 *. Class f: Membrane and cell surface ... Class f: Membrane and cell surface proteins and peptides first appeared (with stable ids) in SCOP 1.55. * ...
Lung Inspired Energy- and Material-Efficient Design of a Polymer Electrolyte Membrane Fuel Cell | NextBigFuture.com
Lung Inspired Energy- and Material-Efficient Design of a Polymer Electrolyte Membrane Fuel Cell. April 7, 2017. August 22, 2010 ... Home » Uncategorized » Lung Inspired Energy- and Material-Efficient Design of a Polymer Electrolyte Membrane Fuel Cell ... Energy Fuels Journal - Nature-Inspired Energy- and Material-Efficient Design of a Polymer Electrolyte Membrane Fuel Cell. ... is presented that improves the energy efficiency and saves catalyst material of a polymer electrolyte membrane fuel cell (PEMFC ...
Polymer electrolyte membranes for use in fuel cells - Patent EP-1474839-B1 - PubChem
Buchbeschreibung: Christian Siegel : High temperature polymer electrolyte membrane fuel cells. Modeling, simulation, and...
Christian Siegel High temperature polymer electrolyte membrane fuel cells. Modeling, simulation, and segmented measurements ... High temperature polymer electrolyte membrane fuel cells. Modeling, simulation, and segmented measurements Christian Siegel ... For large fuel cells and complete fuel cell stacks in particular, well designed anode and cathode inlet and outlet sections are ... A three-dimensional computational fluid dynamics model of a high temperature polymer electrolyte membrane fuel cell, employing ...
cell-cell adhesion via plasma-membrane adhesion molecules - Ontology Browser - Rat Genome Database
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules + calcium-independent cell-cell adhesion via ... heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules homophilic cell adhesion via plasma membrane ... cell-cell adhesion mediated by integrin + cell-cell adhesion via plasma-membrane adhesion molecules + The attachment of one ... cell-cell adhesion involved in ameboidal cell migration + cell-cell adhesion involved in cerebral cortex tangential migration ...
Epiretinal membranes in sickle cell disease. | British Journal of Ophthalmology
Epiretinal membranes at the macula were seen in 4% of the eyes of 355 patients with homozygous sickle cell (SS) disease and ... The occlusion of PSR lesions by treatment appears to reduce the risk of epiretinal membranes being formed. ... and vitreous haemorrhage all constitute risk factors for the formation of epiretinal membranes. ... sickle cell haemoglobin-C (SC) disease under the age of 60 years. The presence of proliferative sickle retinopathy (PSR), the ...
How Plasma Membrane and Cytoskeletal Dynamics Influence Single-Cell Wound Healing: Mechanotransduction, Tension and Tensegrity ...
Similarly, a cell recovers from injuries by replacing damaged components of its structural integrity: its plasma membrane and ... As such, direct or indirect insults to the plasma membrane or cytoskeleton of a cell may not only result in the temporary loss ... how does the cell counteract them and how does the cell return to its previous tensegrity state? These questions will be ... Cells can be thought of as tensegral structures, their structural integrity relying on the interplay between tensile forces ...
ProteinsProteinCytoplasmMoleculesEpithelial CellsVesiclesCellular membranesLipidsCytoplasmic membraneNucleusBlood cell membraneExtracellularBilayerPermeabilityElectrolytePhysiologyPolymerCell'sSynovial membraneBiologicalIntracellularMolecularFuel cellsGlycoproteinsCytosolPEMFCSickle cell diStructuresBiology2020Osmotic fragilityEucaryotic cellsOrganismsSubstrateReceptorsGolgiProton-exchangeEndoplasmicNerveProtonsAlveolarTissuesTransmembraneSelectivelyApoptosisMammalianFusionFluorescenceBehaviorNuclearMorphologyStructuralCompositionReactionsProkaryoticMechanicallyContentFunctionsNutrientsDifferentiationAntigensElectrodeBoundHydrogen
Proteins37
- It gives an overview of membrane proteins, with particular emphasis on peripheral and integral proteins. (merlot.org)
- The user will learn about membrane proteins, their structures, and how they contribute towards cell function. (merlot.org)
- Special proteins inserted in cellular membranes create pores that permit the passage of molecules across them. (nih.gov)
- Ion gradients across membranes, established by the activities of specialized membrane proteins, can be used to synthesize ATP, to drive the transmembrane movement of selected solutes, or, in nerve and muscle cells, to produce and transmit electrical signals. (nih.gov)
- In the plasma membrane, some proteins serve as structural links that connect the cytoskeleton through the lipid bilayer to either the extracellular matrix or an adjacent cell, while others serve as receptors to detect and transduce chemical signals in the cell's environment. (nih.gov)
- As would be expected, it takes many different membrane proteins to enable a cell to function and interact with its environment. (nih.gov)
- In fact, it is estimated that about 30% of the proteins that are encoded in an animal cell's genome are membrane proteins. (nih.gov)
- In this chapter we consider the structure and organization of the two main constituents of biological membranes-the lipids and the membrane proteins. (nih.gov)
- The cell membrane embeds specific proteins that are molecular signals cells use to communicate with one another. (reference.com)
- Other embedded proteins on the cell membrane are markers to identify the cell to other cells. (reference.com)
- The fluid mosaic model describes the cell membrane as a tapestry of several types of molecules (phospholipids, cholesterols, and proteins) that are constantly moving. (khanacademy.org)
- These membranes are extremely thin, oily films, containing proteins and fatty molecules called lipids. (washington.edu)
- A vacuole from a genetically engineered strain of yeast in which membrane proteins fluorescently glow. (washington.edu)
- The UW researchers were inspired by pictures of a genetically engineered strain of yeast in which membrane proteins fluorescently glowed. (washington.edu)
- The proteins lit up intracellular, membrane-bound compartments called vacuoles. (washington.edu)
- The membranes of living systems contain many different types of fats, proteins and other molecules," said co-lead author Scott Rayermann , a lecturer at UW Tacoma who conducted this research when he was a UW doctoral student in chemistry. (washington.edu)
- To show that phase separation occurs, we had to reliably track the distribution of proteins within membranes, show that they formed regions like in artificial systems and that these regions would merge in response to changing environmental conditions. (washington.edu)
- Engagement of the T cell receptor leads to activation of several tyrosine kinases and phosphorylation of many intracellular proteins. (duke.edu)
- Membrane-associated adaptor proteins play an important role in T cell activation by coupling TCR ligation at the membrane to distal signalling cascades. (duke.edu)
- Two other recently identified adaptor proteins, TRIM (T cell receptor interacting molecule) and SIT (SHP2-interacting transmembrane adaptor protein), which constitutively associate with several surface molecules, bind to PI3K and SHP2, respectively, after T cell activation and might also function in the TCR signalling pathway. (duke.edu)
- It acts as an anchor, connecting each muscle cell's structural framework (cytoskeleton) with the lattice of proteins and other molecules outside the cell (extracellular matrix). (medlineplus.gov)
- Most bacteria are, however, surrounded by a rigid cell wall made out of peptidoglycan , a polymer composed of linked carbohydrates and small proteins. (khanacademy.org)
- For instance, although archaea also have a cell wall, it's not made out of peptidoglycan-although it does contain carbohydrates and proteins. (khanacademy.org)
- The small intestines allows properly digested fats, proteins and starches to pass through the cells in order to be used by the body while providing a barrier to keep out foreign substances, large undigested molecules and bacterial products. (robbwolf.com)
- a IL-1 gene manifestation was considerably less pronounced in PKRA7-treated mice (ideals by Mann-Whitney check Discussion In today's study, we exhibited that PKR1 proteins was indicated in infiltrating neutrophils, while PKR2 proteins was within macrophage-like mononuclear cells in the synovial membrane of CIA mice. (exposed-skin-care.net)
- We discovered that PKR2 proteins was within macrophage-like cells in the synovial membrane of CIA mice which, unlike PKR1, PKR2 gene manifestation was even more pronounced in swollen joints. (exposed-skin-care.net)
- Most cells contain ribosomes , which are structures that combine amino acids to create proteins. (visiblebody.com)
- Our cells do a lot for us: they synthesize proteins, convert nutrients from our food into energy we can use, and make up the tissues and organs in our bodies. (visiblebody.com)
- Cytoskeleton offers several reagents for live-cell research including fluorescent proteins, cell permeable protein activators and inhibitors, as well as our recent addition of live cell imaging probes. (cytoskeleton.com)
- The free radicals and oxidative environment can damage DNA proteins and lipids in the skin cells. (naturalproductsinsider.com)
- called peripheral membrane proteins. (freezingblue.com)
- Almost four decades of research have led scientists at Japan's Institute for Integrated Cell-Material Sciences (iCeMS) to propose that a family of transporter proteins has played an important role in species evolution. (vectorsjournal.org)
- There are different types of ABC proteins with different transportation roles, importing nutrients into cells, exporting toxic compounds outside them, and regulating lipid concentrations within cell membranes. (vectorsjournal.org)
- Organisms that existed early in Earth's history were probably formed of DNA and proteins surrounded by a leaky lipid membrane. (vectorsjournal.org)
- The ABC proteins also played important roles in generating an outer membrane that protected cells from external stresses and in removing harmful substances from inside. (vectorsjournal.org)
- The resultant accumulation of cholesterol in the inner leaflet triggers the recruitment of proteins to the membrane and modulates the signal transduction. (vectorsjournal.org)
- Extracellular vesicles (EVs) are small membrane-bound vesicles secreted by all cells, circulate at high levels, and convey nucleic acids, peptide/proteins, lipids. (selectbiosciences.com)
Protein25
- The bacterial protein shown here uses the energy from light (photons) to activate the pumping of protons across the plasma membrane. (nih.gov)
- these protein sensors, or receptors, transfer information-rather than ions or molecules-across the membrane. (nih.gov)
- Despite their differing functions, all biological membranes have a common general structure: each is a very thin film of lipid and protein molecules, held together mainly by noncovalent interactions. (nih.gov)
- Protein molecules that span the lipid bilayer mediate nearly all of the other functions of the membrane, transporting specific molecules across it, for example, or catalyzing membrane-associated reactions, such as ATP synthesis. (nih.gov)
- In Chapters 12 and 13 we discuss the internal membranes of the cell and the protein traffic through and between them. (nih.gov)
- These protein receptors receive signals from other cells as well as the environment. (reference.com)
- The research, led by neuroscientist Kirill Martemyanov, PhD, and colleagues, indicates that PTCHD1, a protein that is involved in altering cholesterol content in a cell's membrane, is involved in controlling opioid responses by regulating µ-opioid receptor (MOR) trafficking. (genengnews.com)
- Hundreds of receptors known as G protein-coupled receptors (GPCRs) act as landing sites for medications and biological molecules on the surface of cells. (genengnews.com)
- One gene, PTR-25, which encoded a membrane protein stood out. (genengnews.com)
- The results show that the membrane composition has a small contribution to the increased bending rigidity and suggests additional protein-driven mechanisms. (plos.org)
- Experiments were designed to precisely characterize the ontogenic processes of developing granule cells by combining organotypic cerebellar cultures with the specific expression of EGFP (enhanced green fluorescent protein) in granule cells by use of DNA transfection. (jneurosci.org)
- To address these questions, this present investigation combined the use of organotypic cerebellar cultures and green fluorescent protein (GFP)-expressing granule cells obtained by DNA transfection. (jneurosci.org)
- For decades, scientists have argued about how cell membranes organize and maintain distinct regions enriched in particular protein and lipid types. (washington.edu)
- During astrocyte differentiation, membrane tension initially decreases and then increases after 72 h, accompanied by consolidation of glial fibrillary acidic protein expression and striking actin reorganization, while bending modulus increases following observed alterations. (bvsalud.org)
- For oligodendrocytes , the changes in membrane tension are less abrupt over the first hours, but their values subsequently decrease, correlating with a shift from oligodendrocyte marker O4 to myelin basic protein expressions and a remarkable actin reorganization, while bending modulus remains constant. (bvsalud.org)
- The sarcoglycan protein complex is located in the membrane surrounding muscle cells. (medlineplus.gov)
- Nearly all pathogens, including cancer cells, are protected by a protein-based coating, or "fibrin", that makes it difficult for the immune system to identify and destroy them. (naturalnews.com)
- This post-translational modification is used to anchor the protein into membranes within the cell. (iucr.org)
- Data was from mice sacrificed on Times 21, 28, and 35 Immunohistochemical staining of PKR1 and PKR2 protein demonstrated that PKR1-positive cells had been mainly neutrophils infiltrating in the synovial membrane (Fig.?4a). (exposed-skin-care.net)
- Open up in another windows Fig. 4 Immunostaining of PKR1 and PKR2 protein in synovial cells. (exposed-skin-care.net)
- The cell consists of a permeable cell membrane, DNA, protein factories called ribosomes, and a protective outer cell wall. (si.edu)
- plasma membrane of the cell, the heavy chain is called an integral membrane protein. (freezingblue.com)
- The ABCA1 protein flips the cholesterol from the inner to the outer layer of the cell membrane. (vectorsjournal.org)
- One protein in particular, called ABCA1, was likely crucial for vertebrate evolution by helping regulate when signals involved in cell proliferation, differentiation and migration enter a cell. (vectorsjournal.org)
- The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells. (bvsalud.org)
Cytoplasm5
- Cell walls anchor the cytoplasm and hold the cell's shape. (reference.com)
- The spatial distributions of induced 27 or 2450 MHz radiofrequency (RF) electric fields (E-fields) and specific absorption rates (SARs) in a three-component spherical cell model (cytoplasm, membrane, extracellular space) were determined by Mie scattering theory. (cdc.gov)
- Cytoplasm consists of the jelly-like cytosol inside the cell, plus the cellular structures suspended in it. (khanacademy.org)
- In eukaryotes, cytoplasm specifically means the region outside the nucleus but inside the plasma membrane. (khanacademy.org)
- The interior of all cells consists of cytoplasm filled with a jelly-like substance called cytosol. (visiblebody.com)
Molecules10
- Cell membranes are dynamic, fluid structures, and most of their molecules are able to move about in the plane of the membrane. (nih.gov)
- This lipid bilayer provides the basic fluid structure of the membrane and serves as a relatively impermeable barrier to the passage of most water-soluble molecules. (nih.gov)
- The scientists engineered a microfluidic device containing an array of microscopic cups, each trapping a single droplet of water bathed in oil and lipids, the molecules that make up cellular membranes. (scripps.edu)
- This characteristic allows certain molecules to come in and out of the cell? (studystack.com)
- In a paper published Dec. 5 in the Biophysical Journal , scientists at the University of Washington show for the first time that the complex distribution of molecules within a membrane of a living yeast cell arises through demixing. (washington.edu)
- Each of these types of molecules harbors different physical and chemical properties with the potential to affect the properties of the membrane as a whole. (washington.edu)
- We and other groups have hypothesized that this variety of molecules would allow membranes to phase separate by composition into discrete regions. (washington.edu)
- The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. (mcw.edu)
- The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
- LAT (linker for activation of T cells) is an adaptor molecule, which following its phosphorylation associates with Grb2, Gads, PLC-gamma 1, and other signalling molecules. (duke.edu)
Epithelial Cells5
- Exciting discoveries in the last decade have cast light onto the fundamental mechanisms that underlie polarized trafficking in epithelial cells. (elsevier.com)
- SARS-CoV-1 and SARS-CoV-2, which share about 80% structural identity, do this by harnessing the action of the angiotensin converting enzyme, ACE-2, which is expressed in the membranes of many cells in the body, including lung alveolar epithelial cells. (cebm.net)
- Human alveolar epithelial cells and pulmonary microvascular endothelial cells are cultured on either side of the porous membrane. (news-medical.net)
- In between the epithelial cells are tight junctions held together by the junctional complex. (robbwolf.com)
- When the junctional complex is disrupted, the epithelial cells separate and allow particles into the body without policing them. (robbwolf.com)
Vesicles4
- To address these issues, we analyzed the morphology, molecular composition, fusion capacity and biological activity of Cytochalasin B-induced membrane vesicles (CIMVs). (oncotarget.com)
- Oligodendrocytes at later differentiation stages show membrane vesicles with similar membrane tension but higher bending modulus as compared to the cell surface. (bvsalud.org)
- Illustration of membrane-bound vesicles containing clusters of viruses, including rotavirus and norovirus, within the gut. (nih.gov)
- However, in 2015 Altan-Bonnet and her colleagues showed that polioviruses could transmit themselves in packets, or membrane-bound vesicles containing multiple virus particles. (nih.gov)
Cellular membranes1
- In 1982 John Vane won a Nobel Prize and a knighthood for his work on eicosanoids, local hormones produced by cellular membranes. (canceractive.com)
Lipids2
- The computer-controlled microfluidic circuits we have constructed will allow us to assemble synthetic cells not only from biologically derived lipids, but from any amphiphile and to measure important chemical and physical parameters, such as permeability and stability," said Paegel. (scripps.edu)
- The lipophilic CellBrite® dyes would not be suitable for solvent-cleared samples as membrane lipids would be extracted during the solvent treatment step. (biotium.com)
Cytoplasmic membrane3
- We extracted the RBC's cytoplasmic membrane (RBC cm ) to study the effect of storage on the membranes' molecular structure and bending rigidity by a combination of X-ray diffraction (XRD), X-ray diffuse scattering (XDS) and coarse grained Molecular Dynamics (MD) simulations. (plos.org)
- Himbert S, Qadri SM, Sheffield WP, Schubert P, D'Alessandro A, Rheinstädter MC (2021) Blood bank storage of red blood cells increases RBC cytoplasmic membrane order and bending rigidity. (plos.org)
- The RBCs' unique ability to deform is intrinsically related to the complex interplay between the spectrin network and the cytoplasmic membrane, which form the outer layer of the cell. (plos.org)
Nucleus8
- We can now control the molecular composition of the inner and outer layers of a bilayer membrane, and even assemble multi-layered membranes that resemble the envelope of the cell nucleus. (scripps.edu)
- A prokaryote is a simple, single-celled organism that lacks a nucleus and membrane-bound organelles. (khanacademy.org)
- We'll talk more about the nucleus and organelles in the next article on eukaryotic cells, but the main thing to keep in mind for now is that prokaryotic cells are not divided up on the inside by membrane walls, but consist instead of a single open space. (khanacademy.org)
- The nucleus of a eukaryotic cell contains its DNA. (visiblebody.com)
- Prokaryotic cells don't contain a nucleus. (visiblebody.com)
- Eukaryotic cells have a membrane-bound nucleus where their DNA is stored. (visiblebody.com)
- Margins of ulcers showed marked epidermal swelling (intracellular edema, ballooning degeneration) and large numbers of epithelial syncytial cells, often with marginated chromatin and smudgy intranuclear inclusion bodies filling the nucleus ( Figure 1 , panel B.). Inclusion bodies were present in individual cells in the stratum basalis and stratum spinosum adjacent to the ulcers. (cdc.gov)
- Using transmission electron microscopy, we observed virions consistent with herpesvirus in shape and size within the nucleus of syncytial cells and budding through the nuclear membrane ( Figure 1 , panel C.). Histopathology and transmission electron microscopy findings were essentially identical to findings from human HSV-1 infections ( 7 ). (cdc.gov)
Blood cell membrane4
- Forster RE, Gros G, Lin L, Ono Y, Wunder M. The effect of 4,4'-diisothiocyanato-stilbene-2,2'-disulfonate on CO2 permeability of the red blood cell membrane. (harvard.edu)
- Hemolytic anemias: red blood cell membrane and metabolic defects. (medlineplus.gov)
- Red blood cell membrane disorders. (medlineplus.gov)
- Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity. (nih.gov)
Extracellular4
- The plasma membrane encloses the cell, defines its boundaries, and maintains the essential differences between the cytosol and the extracellular environment. (nih.gov)
- Organisms are able to recover from injuries by replacing damaged tissues, which recover by replacing damaged cells and extracellular structures. (intechopen.com)
- Canonically, PS is exposed to the extracellular (outer) leaflet of the plasma membrane in an irreversible manner when cells undergo apoptosis, marking them for clearing by macrophages. (tmc.edu)
- The results were compared to results for the same cell model but with 0.5 nm thick of bound water on the inner (cytoplasmic) and outer (extracellular) membrane surfaces (i.e., five-component cell model). (cdc.gov)
Bilayer6
- We can now control the molecular composition of the inner and outer layers of a bilayer membrane," says Assistant Professor Brian Paegel. (scripps.edu)
- Because when you understand what a phospholipid is, it starts to make sense why it would form a bilayer like this, and why it's the basis for so many membranes in biological systems. (khanacademy.org)
- For example, the lipid bilayer is the fundamental structure of cell membranes, and the structure and dynamic of bilayer membranes govern the transport of materials and information in and out of cells. (nanowerk.com)
- B) Atomic force microscope topography and (C) structural model of DOPC bilayer membranes on GO/SiO 2 /Si. (nanowerk.com)
- Subsequent observation with an atomic force fluorescence microscopy (Fig.1B) and revealed the presence of two planar DOPC bilayer membranes stacked on GO with the assistance of calcium ion (5 mM), and that the DOPC bilayers on GO were fluid and continuous with the surrounding DOPC bilayers on the bare SiO 2 surfaces (Fig. 1C). (nanowerk.com)
- Mammalian cells maintain a distinct disparity in lipid composition between the two leaflets of the bilayer of the plasma membrane. (tmc.edu)
Permeability5
- Through the investigations on water/methanol uptake, swelling, and methanol permeability, it was found that the membrane performance was highly dependent on the zeolite particle and pore size, content, and hydrophilic/hydrophobic nature. (harvard.edu)
- Moreover, under the identical conditions, all the as-prepared membranes exhibited much lower methanol permeability than Nafion ® 117 while the proton conductivity of the membranes remained high enough for DMFC applications. (harvard.edu)
- The interesting finding is that membrane CO2 permeability, from a value of 1cm/sec or higher in the control experiments, was lowered by the drug to a value of 0.1cm/sec. (harvard.edu)
- Once intestinal permeability is increased and a leaky gut is present, the antigen enters the body and stimulates the cell-mediated immune response. (robbwolf.com)
- Cholesterol's role was thought to focus mainly on physically strengthening the cell membrane and reducing its permeability to ions. (vectorsjournal.org)
Electrolyte5
- A design procedure is presented that improves the energy efficiency and saves catalyst material of a polymer electrolyte membrane fuel cell (PEMFC). (nextbigfuture.com)
- Buchbeschreibung: Christian Siegel : High temperature polymer electrolyte membrane fuel cells. (logos-verlag.de)
- A three-dimensional computational fluid dynamics model of a high temperature polymer electrolyte membrane fuel cell, employing a high temperature stable polybenzimidazole membrane electrode assembly doped with phosphoric acid, was developed and implemented using a commercially available finite element software. (logos-verlag.de)
- This work helps to provide a better understanding of the internal behaviour of a running high temperature polymer electrolyte membrane fuel cell and presents valuable data for modeling and simulation. (logos-verlag.de)
- The Proton Exchange Membrane Fuel Cell (PEMFC) technology is a type of fuel cell that uses a proton-conducting membrane as the electrolyte. (express-press-release.net)
Physiology2
- This work paves the way for future studies to determine the broad roles of compositional and biophysical plasma membrane asymmetry in cellular physiology, and the specific mechanisms by which it is involved in various cell signaling pathways. (tmc.edu)
- MSc in Cell Biology, Physiology and Pathology. (bvsalud.org)
Polymer1
- More specifically, each organ-on-a-chip is fabricated on a clear polymer containing hollow microfluidic channels lined with living human cells. (news-medical.net)
Cell's1
- The plasma membrane is an outer covering that separates the cell's interior from its surrounding environment. (khanacademy.org)
Synovial membrane4
- Detection of cytokine producing cells in the synovial membrane from patients with rheumatoid arthritis. (bmj.com)
- b Hematoxylin and eosin staining from the rearfoot synovial membrane of control CIA mice (100) on Day time 35. (exposed-skin-care.net)
- In swollen joints, consequently, PKR1 manifestation is likely within those bloodstream cells infiltrating the synovial membrane. (exposed-skin-care.net)
- We discovered that PKR1 was indicated in neutrophils in the synovial membrane. (exposed-skin-care.net)
Biological1
- The membranes surrounding and inside cells are involved in every aspect of biological function. (scripps.edu)
Intracellular3
- You will compare external addition of membrane material with intracellular biosynthesis of the membrane building blocks, called phospholipids. (tudelft.nl)
- This Ca 2+ signaling should greatly influence intracellular signaling mechanisms of developing and maturing granule cells. (jneurosci.org)
- It is now clear that epithelial cell membrane asymmetry is achieved by a combination of intracellular sorting operations, vectorial delivery mechanisms and plasmalemma-specific fusion and retention processes. (elsevier.com)
Molecular6
- The physical process of dividing a single cell into two daughter cells has been a fascinating research question for decades, and its molecular basis is still far from understood. (tudelft.nl)
- Layer-by-layer membrane assembly allows us to create synthetic cells with membranes of arbitrary complexity at the molecular and supramolecular scale," said TSRI Assistant Professor Brian Paegel, who authored the study with Research Associate Sandro Matosevic. (scripps.edu)
- From these studies, we suspect that targeting the molecular organization of CD82 may provide a means by which AML cells can be released from the bone marrow, while attenuate uncontrolled signaling in AML. (unm.edu)
- Ozawa E, Mizuno Y, Hagiwara Y, Sasaoka T, Yoshida M. Molecular and cell biology of the sarcoglycan complex. (medlineplus.gov)
- The Red Cell Service has close links with the University of Oxford through internationally recognised units and laboratories with an interest in disorders of haemoglobin, including the MRC Molecular Haematology Unit within the Weatherall Institute of Molecular Medicine (WIMM). (ouh.nhs.uk)
- Tobacco plants have evolved a chemical called nicotine that locks into particular molecular receptors in the outer membranes of certain animal nerve cells. (economist.com)
Fuel cells7
- Proton exchange membrane fuel cells 9. (fraunhofer.de)
- For large fuel cells and complete fuel cell stacks in particular, well designed anode and cathode inlet and outlet sections are expected to aid in achieving flatter quantities distributions and in preventing hot spots over the membrane electrode assembly area, and to develop proper start-up, shut-down, and tempering concepts. (logos-verlag.de)
- Computational modeling of transport and electrochemical reactions in proton-exchange membrane fuel cells. (cmu.ac.th)
- PEMFCs have a number of advantages over other types of fuel cells, including high power density, high efficiency, and low emissions. (express-press-release.net)
- The key drivers of the Proton Exchange Membrane Fuel Cell (PEMFC) market are the increasing demand for fuel cells, the need for clean energy, and government support for fuel cells. (express-press-release.net)
- Fuel cells are a clean and efficient way to generate electricity, and they are being increasingly used in a variety of applications, such as power generation, transportation, and portable electronics. (express-press-release.net)
- Fuel cells offer many advantages over traditional combustion-based power generation technologies, including higher efficiency, lower emissions, and the ability to operate using a variety of fuels. (express-press-release.net)
Glycoproteins3
- Staining using CF® Dye WGA Conjugates may be an option, but staining can be cell- and tissue-type dependent i.e. it is based on the expression pattern of glycoproteins on the cell membranes. (biotium.com)
- It is also important to note that if tissue sections are used, the lectins would stain glycoproteins on all cell membranes, external (plasma membrane) as well as internal (organelle membranes). (biotium.com)
- Their resemblance to the sun with a corona, as seen during an eclipse, is due to so-called spike glycoproteins, or peplomers, on the surface, which enable coronaviruses to enter host cells. (cebm.net)
Cytosol4
- Inside eucaryotic cells, the membranes of the endoplasmic reticulum, Golgi apparatus, mitochondria, and other membrane-enclosed organelles maintain the characteristic differences between the contents of each organelle and the cytosol. (nih.gov)
- Association of AP-1 with the membranes required GTP or GTP analogues and was inhibited by the fungal metabolite, brefeldin A. In the presence of GTP gamma S, binding of AP-1 to Golgi membranes was strictly dependent on the concentration of cytosol added to the assay. (rupress.org)
- Using only an adaptor-enriched fraction from cytosol, purified myristoylated ARF1, and Golgi membranes, the GTP gamma S-dependent recruitment of AP-1 could be reconstituted. (rupress.org)
- Structures inside the cell are suspended in the cytosol. (visiblebody.com)
PEMFC5
- A quasi three-dimensional dynamic model of a proton exchange membrane fuel cell (PEMFC) has been developed and evaluated by comparison to experimental data. (escholarship.org)
- A single PEMFC cell is discretized into 245 control volumes in three dimensions to resolves local voltage response, current generation, species mole fractions, temperature, and membrane hydration spatially in the PEMFC. (escholarship.org)
- New York, 2022-Aug-12 - /EPR Network/ - According to a new market research report published by Global Insight Services " Proton Exchange Membrane Fuel Cell (PEMFC) Market " is expected to reach US$ XX bn by 2031. (express-press-release.net)
- A Proton Exchange Membrane Fuel Cell (PEMFC) is a type of fuel cell that uses hydrogen and oxygen to produce electricity. (express-press-release.net)
- The Proton Exchange Membrane Fuel Cell (PEMFC) Market is segmented by type, application, and region. (express-press-release.net)
Sickle cell di4
- Epiretinal membranes in sickle cell disease. (bmj.com)
- The Red Cell Service provides a comprehensive clinical service for the population of Oxfordshire and acts as the hub for major haemoglobinopathy referrals for tertiary care from the Thames Valley network - sickle cell disease, thalassaemia and rare inherited anaemia. (ouh.nhs.uk)
- Exchange blood transfusions for people with sickle cell disease are carried out by the Therapeutic Apheresis Services (TAS) at the NHS Blood and Transplant Centre on the John Radcliffe Hospital site. (ouh.nhs.uk)
- If you are worried that you need urgent attention for your blood disorder, or have a medical concern (e.g. if you have a sickle cell disease and think you might be developing a crisis), we have a dedicated triage assessment team. (ouh.nhs.uk)
Structures10
- This page is a subset of reference material about cell structures. (merlot.org)
- They are also the largest and most complex structures that cells synthesize. (scripps.edu)
- Understanding the myriad biochemical roles of membranes requires the ability to prepare synthetic versions of these complex multi-layered structures, which has been a long-standing challenge. (scripps.edu)
- Similarly, a cell recovers from injuries by replacing damaged components of its structural integrity: its plasma membrane and cytoskeletal structures. (intechopen.com)
- Cells can be thought of as tensegral structures, their structural integrity relying on the interplay between tensile forces generated within and without the cell, and the compressive elements that counteracts them. (intechopen.com)
- Cells are neither amorphous blobs nor rigid, unchanging structures. (intechopen.com)
- Virus alters the mechanical properties of the membranes, impairing mesophase structures mediated by the fractal architecture initiated by actomyosin. (arxiv.org)
- Some bacteria also have specialized structures found on the cell surface, which may help them move, stick to surfaces, or even exchange genetic material with other bacteria. (khanacademy.org)
- Fimbriae are numerous, hair-like structures that are used for attachment to host cells and other surfaces. (khanacademy.org)
- Eukaryotic cells contain smaller structures, called organelles , that help it carry out these functions. (visiblebody.com)
Biology3
- Gyorgy Panyi has been a professor and head of Biophysics at the University of Debrecen, Faculty of Medicine, Department of Biophysics and Cell Biology, Hungary, since 2009. (meduniwien.ac.at)
- UW has been at the forefront of yeast genetics and cell biology for over 60 years. (washington.edu)
- En la mayorÃa de las células microbianas, ésta aparece bordeada externamente por la PARED CELULAR (Singleton & Sainsbury, Dictionary of Microbiology and Mollecular Biology, 2d ed). (bvsalud.org)
20201
- Cells;9(6)2020 05 26. (bvsalud.org)
Osmotic fragility1
- Osmotic fragility is a blood test to detect whether red blood cells are more likely to break down. (medlineplus.gov)
Eucaryotic cells1
- Cellular pharmacokinetics of antibiotics : study of the mechanisms of penetration, accumulation, distribution, and efflux of antibiotics in eucaryotic cells, including the study of their transport by eucaryotic efflux pumps. (uclouvain.be)
Organisms7
- In complex organisms, the cell wall attaches to the cell walls of other cells to form tissues, organs and ultimately the organism. (reference.com)
- Some organisms consist of only one cell, while others (like humans) have trillions of cells! (visiblebody.com)
- All living organisms have cells that contain genetic material ( DNA ). (visiblebody.com)
- Prokaryotes-organisms composed of a prokaryotic cell-are always single-celled (unicellular). (visiblebody.com)
- Eukaryotes-organisms composed of eukaryotic cells-are multicellular or complex unicellular organisms. (visiblebody.com)
- As the organisms evolved, their membranes were fortified to protect them from the external environment. (vectorsjournal.org)
- But this meant only organisms that evolved special ABC transporters capable of carrying nutrients across the membrane survived. (vectorsjournal.org)
Substrate1
- The majority of organ-on-a-chip models utilize a porous membrane as a substrate for defining cell layers. (news-medical.net)
Receptors1
- It is demonstrated that [3H]ICS 205-930 identifies 5-HT3 receptors in preparations of cat and rabbit vagus nerve and superior cervical ganglion and their rank order of affinity for 5- HT3 receptors from neuroblastoma-glioma NG 108-15 cells. (semanticscholar.org)
Golgi4
- Biochemical dissection of AP-1 recruitment onto Golgi membranes. (rupress.org)
- Recruitment of the Golgi-specific AP-1 adaptor complex onto Golgi membranes is thought to be a prerequisite for clathrin coat assembly on the TGN. (rupress.org)
- We have used an in vitro assay to examine the translocation of cytosolic AP-1 onto purified Golgi membranes. (rupress.org)
- Our results show that the association of the AP-1 complex with Golgi membranes, like the coatomer complex, requires ARF, which accounts for the sensitivity of both to brefeldin A. In addition, they provide the basis for a model for the early biochemical events that lead to clathrin-coated vesicle formation on the TGN. (rupress.org)
Proton-exchange1
- By type, the market is divided into low-temperature proton exchange membrane fuel cell, high-temperature proton exchange membrane fuel cell. (express-press-release.net)
Endoplasmic2
- Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells. (genscript.com)
- Data show that junctophilin-4 (JP4) is expressed in T cells and localized at the endoplasmic reticulum-plasma membrane junctions to regulate Ca(2+) signaling. (genscript.com)
Nerve3
- Nerve growth factor induces 5-HT3 recognition sites in rat pheochromocytoma (PC12) cells. (semanticscholar.org)
- Fats are nutrients in food that the body uses to build cell membranes, nerve tissue (including the brain), and hormones. (kidshealth.org)
- The acute transient neurotoxicity observed in rats exposed to MeI is best supported by a mode of action involv- ing modification of ion currents by the parent chemical in nerve cells. (cdc.gov)
Protons1
- The hydrogen ions (protons) pass through the membrane and react with oxygen to produce water and electricity. (express-press-release.net)
Alveolar1
- There the microbe encounters the alveolar macrophage (AMac) and submucosal dendritic cell (DC). (intechopen.com)
Tissues2
- This procedure is hypothetically generic for enhancing delivery to all tissues, according to coauthor Victor Frenkel, Ph.D. Li previously demonstrated that tumor cells increase their uptake of chemotherapeutic drugs with a similar ultrasound treatment. (diagnosticimaging.com)
- However, if staining of live cells is possible, the reactive CellBrite® fix and MemBrite® fix membrane dyes may be used before fixation and solvent-clearing, but these dyes may not penetrate multilayer cells or tissues effectively. (biotium.com)
Transmembrane1
- A host transmembrane serine protease, TMPRSS2 , promotes entry of SARS-Cov into cells by two separate mechanisms . (cebm.net)
Selectively2
- Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells. (meduniwien.ac.at)
- It has been concluded that LLO Y406A has the ability to selectively eliminate cancer urothelial cells through pore-forming activity at the plasma membrane, without cytotoxic effects on normal urothelial cells. (dissem.in)
Apoptosis3
- LLO Y406A decreased viability, altered cell morphology, provoked membrane blebbing, and induced apoptosis in RT4 cells, while it did not affect NPU cells. (dissem.in)
- Capsid gene delivery into the striatum of mouse brain or interskeletal muscle resulted in cell death and inflammation, likely through capsid-induced apoptosis in vivo. (cdc.gov)
- Semithin (1.0-µm) sections resulted in apoptosis and inflammation of muscle cells. (cdc.gov)
Mammalian1
- Absorbed energy distribution from radiofrequency electromagnetic radiation in a mammalian cell model: effect of membrane-bound water. (cdc.gov)
Fusion1
- TMPRSS2 also acts on the S2 subunit of the spike glycoprotein, causing an irreversible conformational change, activating it, and facilitating fusion of the virus to the cell membrane. (cebm.net)
Fluorescence4
- Stained histologic sections reveal the nuclei of tumor cells in blue as seen with fluorescence microscopy. (diagnosticimaging.com)
- Therefore, our goal was to compare the cytotoxic effect of LLO Y406A on cancer cells (RT4) and normal urothelial cells (NPU), and to identify which cell membranes are the primary target of LLO Y406A by viability assays, life-cell imaging, fluorescence, and electron microscopy. (dissem.in)
- A Multimodal Multi-Shank Fluorescence Neural Probe for Cell-Type-Specific Electrophysiology in Multiple Regions across a Neural Circuit. (neurotree.org)
- Ross B, Loew LM, Baker B . Decision letter: Optical estimation of absolute membrane potential using fluorescence lifetime imaging Elife . (neurotree.org)
Behavior2
- With this tuning, the model is shown to predict well the voltage current (V-I) behavior for the full range of cell operating current. (escholarship.org)
- Although such behavior has been observed across many different immune cell types, so far, no functional role has been attributed to it. (tmc.edu)
Nuclear2
- material in a eukaryotic cell is called the nuclear membrane. (freezingblue.com)
- We report that the WNV capsid (Cp) by itself induces rapid nuclear condensation and cell death in tissue culture. (cdc.gov)
Morphology3
- Multiple approaches using morphology, electrophysiology, and immunohistochemistry demonstrated that granule cells developed and matured at the physiological KCl concentration in organotypic cultures in a temporally regulated manner. (jneurosci.org)
- Here, by precisely measuring membrane tension and bending modulus, we map their variations and correlate them with changes in neural precursor cell morphology along their distinct differentiation fates. (bvsalud.org)
- The structure of individual organ-on-chip systems varies because the arrangement of organ specific cell types within the microfluidic device is made to resemble the basic morphology of the organ. (news-medical.net)
Structural2
- As such, direct or indirect insults to the plasma membrane or cytoskeleton of a cell may not only result in the temporary loss of structural integrity, but also directly impact its ability to respond to its environment. (intechopen.com)
- Although this compositional asymmetry has been known for decades, there has been little investigation of its structural impact on the physical properties of the membrane, nor its functional impact in healthy cells. (tmc.edu)
Composition1
- Special attention will be given to changes in plasma membrane composition and area to cytoskeletal dynamics, and how these factor each other to influence and effect single-cell repair. (intechopen.com)
Reactions2
- Artificial lipid bilayers on graphene and its derivatives could be a new cell membrane model system for the researche on fundamental processes in cell membrane reactions. (nanowerk.com)
- The reactions take place in an airtight 3-ml glass water-jacketed and stirred chamber connected to the ion source of a mass spectrometer through a thin 0.012-mm-thick Teflon membrane supported by a sintered glass disc, through which gases are dissolved in the solution diffuse. (harvard.edu)
Prokaryotic7
- Characteristics of prokaryotic cells. (khanacademy.org)
- It also means that you-for some definition of the word you-actually consist of both of the major types of cells: prokaryotic and eukaryotic. (khanacademy.org)
- There are some key ingredients that a cell needs in order to be a cell, regardless of whether it is prokaryotic or eukaryotic. (khanacademy.org)
- Image of a typical prokaryotic cell, with different portions of the cell labeled. (khanacademy.org)
- Typical prokaryotic cells range from 0.1 to 5.0 micrometers (μm) in diameter and are significantly smaller than eukaryotic cells, which usually have diameters ranging from 10 to 100 μm. (khanacademy.org)
- 4. There are two main types of cells: prokaryotic cells and eukaryotic cells. (visiblebody.com)
- Prokaryotic cells include bacteria and archaea. (visiblebody.com)
Mechanically1
- You will mechanically characterize and quantify the membrane growth. (tudelft.nl)
Content1
- In the first experiment of the current study, the effect of oxygen free radical scavengers (SOD+CAT) on blood flow, ATP content, and plasma cell membrane potential in the liver was evaluated after resuscitation from hemorrhagic shock. (nii.ac.jp)
Functions5
- The functions of cell membranes are considered in later chapters. (nih.gov)
- The cell membrane provides several vital functions for the cell. (reference.com)
- Cell Structure and Functions - A cellular can mirror itself independently. (articlesfly.com)
- By teaming up with Alex Merz , a UW professor of biochemistry and a yeast expert, we've shown that phase separation is one of those tools to shape membranes and their functions within a living system. (washington.edu)
- Neural precursor cells differentiate into several cell types that display distinct functions. (bvsalud.org)
Nutrients1
- Cells absorb nutrients through the cell membrane and expel waste through the same membrane using both active and passive transport. (reference.com)
Differentiation3
- Membrane Elastic Properties During Neural Precursor Cell Differentiation. (bvsalud.org)
- However, little is known about how cell surface mechanics vary during the differentiation process. (bvsalud.org)
- Altogether, our results display an entire spectrum of how membrane elastic properties are varying, thus contributing to a better understanding of neural differentiation from a mechanobiological perspective. (bvsalud.org)
Antigens2
- The antigens (either dietary related or microbial or viral) pass through the weakened junctional complex(JC), they are presented by an antigen-presenting cell (APC) to the T-cells (a lymphocyte produced by the Thymus gland). (robbwolf.com)
- The infectivity of the virus was titrated study, we used beta-propiolactone (BPL)- by the focus-forming method in Vero inactivated dengue viruses as antigens in cells(6). (who.int)
Electrode1
- The general results are illustrated using the standard E-TEK Elat/Std/DS/V2 gas diffusion electrode with 0.5 mg of Pt/cm2 membrane area and 20% Pt/C on Vulcan XC-72 as a support material. (nextbigfuture.com)
Bound6
- In order to estimate the dependence of the results on bound water within the membrane per se, the model was revised to include bound water within the inner and outer membrane surfaces. (cdc.gov)
- and (7) variation of bound-water characteristic frequency, ionic conductivity, or bound-water incorporation inside the membrane surfaces, per se, did not significantly affect the E-field or SAR ratios. (cdc.gov)
- All cells are bound by a plasma membrane . (visiblebody.com)
- The scientists compared this new model of viral transmission to a Trojan horse: A group of membrane-bound viruses arrives at a host cell and deposits viruses in the cell while dodging detection by the immune system. (nih.gov)
- The researchers obtained fecal samples of humans and animals (pigs and mice) and found that the viruses are shed in the stool as virus clusters inside membrane-bound packets. (nih.gov)
- with the plasma membrane are tightly bound to it. (freezingblue.com)
Hydrogen4
- Learn how chlorine and hydrogen are produced from brine in a modern and efficient membrane cell electrolyser. (ineos.com)
- Membrane cell electrolysers feature a sealed module that consist of two chambers, separated by a flexible cation exchange membrane, to prevent chlorine and hydrogen gasses from mixing. (ineos.com)
- Due to the presence of hydrogen bonds between CS and zeolite, the hybrid membranes displayed desirable thermal and mechanical stabilities. (harvard.edu)
- PEMFCs work by passing hydrogen gas through a membrane. (express-press-release.net)