Methods and techniques used to modify or select cells and develop conditions for growing cells for biosynthetic production of molecules (METABOLIC ENGINEERING), for generation of tissue structures and organs in vitro (TISSUE ENGINEERING), or for other BIOENGINEERING research objectives.
Cells of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B-lymphocytes, can be defined, based on the different classes of immunoglobulins that they synthesize.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
The study of the structure, behavior, growth, reproduction, and pathology of cells; and the function and chemistry of cellular components.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
A bracelet or necklace worn by an individual that alerts emergency personnel of medical information for that individual which could affect their condition or treatment.
Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.
The visually perceived property of objects created by absorption or reflection of specific wavelengths of light.
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Coloration or discoloration of a part by a pigment.
The use of wings or wing-like appendages to remain aloft and move through the air.
A group of FLAVONOIDS derived from FLAVONOLS, which lack the ketone oxygen at the 4-position. They are glycosylated versions of cyanidin, pelargonidin or delphinidin. The conjugated bonds result in blue, red, and purple colors in flowers of plants.
Application of principles and practices of engineering science to biomedical research and health care.
A cell-separation technique where magnetizable microspheres or beads are first coated with monoclonal antibody, allowed to search and bind to target cells, and are then selectively removed when passed through a magnetic field. Among other applications, the technique is commonly used to remove tumor cells from the marrow (BONE MARROW PURGING) of patients who are to undergo autologous bone marrow transplantation.
Enzymes that catalyze the transfer of an aminoacyl group from donor to acceptor resulting in the formation of an ester or amide linkage. EC 2.3.2.
A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.
Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.
Methods utilizing the principles of MICROFLUIDICS for sample handling, reagent mixing, and separation and detection of specific components in fluids.
Rapid methods of measuring the effects of an agent in a biological or chemical assay. The assay usually involves some form of automation or a way to conduct multiple assays at the same time using sample arrays.
Persons living in the United States having origins in any of the black groups of Africa.
Individual members of North American ethnic groups with ancient historic ancestral origins in Asia.
The study of natural phenomena by observation, measurement, and experimentation.
Persons living in the United States having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent.
Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.
Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.
The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components.
Electric power supply devices which convert biological energy, such as chemical energy of metabolism or mechanical energy of periodic movements, into electrical energy.
Devices that control the supply of electric current for running electrical equipment.
A class of devices combining electrical and mechanical components that have at least one of the dimensions in the micrometer range (between 1 micron and 1 millimeter). They include sensors, actuators, microducts, and micropumps.
Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.

Engineering supported membranes for cell biology. (1/57)

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Influence of collagen and chondroitin sulfate (CS) coatings on poly-(lactide-co-glycolide) (PLGA) on MG 63 osteoblast-like cells. (2/57)

Poly-(lactide-co-glycolide) (PLGA) is an FDA-approved biodegradable polymer which has been widely used as a scaffold for tissue engineering applications. Collagen has been used as a coating material for bone contact materials, but relatively little interest has focused on biomimetic coating of PLGA with extracellular matrix components such as collagen and the glycosaminoglycan chondroitin sulfate (CS). In this study, PLGA films were coated with collagen type I or collagen I with CS (collagen I/CS) to investigate the effect of CS on the behaviour of the osteoblastic cell line MG 63. Collagen I/CS coatings promoted a significant increase in cell number after 3 days (in comparison to PLGA) and after 7 days (in comparison to PLGA and collagen-coated PLGA). No influence of collagen I or collagen I/CS coatings on the spreading area after 1 day of culture was observed. However, the cells on collagen I/CS formed numerous filopodia and displayed well developed vinculin-containing focal adhesion plaques. Moreover, these cells contained a significantly higher concentration of osteocalcin, measured per mg of protein, than the cells on the pure collagen coating. Thus, it can be concluded that collagen I/CS coatings promote MG 63 cell proliferation, improve cell adhesion and enhance osteogenic cell differentiation.  (+info)

Concise review: Human cell engineering: cellular reprogramming and genome editing. (3/57)

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Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells. (4/57)

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Introduction to induced pluripotent stem cells: advancing the potential for personalized medicine. (5/57)

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Integration-free iPS cells engineered using human artificial chromosome vectors. (6/57)

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Experimental evolution of a facultative thermophile from a mesophilic ancestor. (7/57)

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Glycoengineering of HCELL, the human bone marrow homing receptor: sweetly programming cell migration. (8/57)

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Karolinska Institute, Department of Cell and Molecular Biology, Stockholm,Sweden. Stem cell engineering of neural stem cells and differentiated neurons. Our studies focus on interactions between neural stem cells or neurons and their microenvironment. We report a conjugated polymer that can control growth factor presentation and thus rat neural stem cell state in vitro. In this context we are also exploring conjugated polymers for controlled small molecule release. Moreover, we are developing cholinergic neural differentiation, highly related to Alzheimers disease, from induced pluripotent stem cells in 2D and 3D hydrogel cultures. In hydrogel cultures we have observed upregulation of signaling pathways related to mechanotransduction and neuroprotection. We are currently establishing new iPS lines derived from Alzheimers patients and controls.. ...
Professional forum and technical support for engineers for Hydrogen and related fuel cell engineering. Includes problem solving collaboration tools.
Professional forum and technical support for engineers for Hydrogen and related fuel cell engineering. Includes problem solving collaboration tools.
Stem cells have shown huge potential for regenerative medicine, but there are several critical issues to be addressed to further improve therapeutic efficacy and regenerative potential of stem cell therapy and stem cell-based tissue engineering. Functional biomaterials can solve these the limitations of current stem cell therapy by promoting prolieration, specific lineage differentiation and improving in vivo survival and engraftment of transplanted stem cells. This thematic series in Biomaterials Research aims to provide collections of recent studies on developing biomaterials for improving stem cell-based regenerative medicine.. To submit a paper to this series, please visit the Biomaterials Research submission site. Make sure to choose the name of the series under the Are you submitting to a thematic series? question on the Additional information tab.. New articles in the series will appear here as they are published.. ...
A Mayo Clinic researcher and his collaborators have developed an online analytic tool that will speed up and enhance the process of re-engineering cells for biomedical investigation. CellNet is a free-use Internet platform ...
TY - CONF. T1 - Silk-based microparticles as an osteogenic scaffold for tissue engineering. AU - Luetchford, Kimberley. AU - Chaudhuri, Julian. AU - De Bank, Paul. N1 - Poster presentation at the Annual Meeting of the Tissue and Cell Engineering Society, 2-4 July 2014, Newcastle University, U.K.. PY - 2014/6. Y1 - 2014/6. M3 - Poster. T2 - Tissue and Cell Engineering Society 2014 Conference. Y2 - 2 July 2014 through 4 July 2014. ER - ...
Methods and techniques used to modify or select cells and develop conditions for growing cells for biosynthetic production of molecules (METABOLIC ENGINEERING), for generation of tissue structures and organs in vitro (TISSUE ENGINEERING), or for other BIOENGINEERING research objectives ...
Lymphyblastic leukemia is a destructive, painful blood cancer that progresses quickly and can be fatal within months if left untreated. And while treatments such as chemotherapy are currently commonly used, many patients suffer relapse, lowering the diseases overall cure rate to between 30 and 40 percent.. But the genetic modification of T-lymphocytes is now emerging as a powerful approach to investigate T cell function. Alliance for Cancer Gene Therapy (ACGT) funded research grants for two investigators work in the area: that of Dr. Michel Sadelain, director of the Center for Cell Engineering & Gene Transfer and Gene Expression Laboratory at Memorial Sloan-Kettering Cancer Center, and Dr. Carl June, professor in Immunotherapy, Pathology and Laboratory Medicine at the University of Pennsylvanias Abramson Cancer Center.. Dr. Sadelains research on T cell engineering and artificial antigen was bolstered by a 2004-2007 ACGT research grant for a program that investigated the therapeutic potential ...
EBV transformed B cell lines derived from Japanese (HEV). ● We are providing B cell lines derived from healthy Japanese and the Japanese patients suffering from cancers etc. The cell lines derived from healthy individuals possess the precise information regarding HLA haplotypes and we are providing such information as well.. ● These cell lines are useful for genetic analyses, and thus we are providing these cell lines for researches including analyses of gene and genome. We provide this collection not only to domestic users in Japan but also to users in overseas, in addition not only to not-for-profit institutions but also to for-profit institutions.. ● Providing B cell lines were transformed by Epstein-Barr Virus.. ● In addition to the cell material itself, we are providing information about gender, age and habit of the individuals who have donated the source cells. When we possess the information of gene and/or genome, we provide them as well.. ● After the providing procedures ...
Genetically engineered cell therapies may bring hope to patients for whom standard treatments have been unsuccessful, according to two separate studies presented at the 2013 ASH Annual Meeting, in New Orleans, Louisiana.
In this study we aimed to set up an in vitro culture of the rabbit amnion in order to support in vivo fetal membrane healing capacity following fetoscopy. Fetal membranes were collected from a mid- gestational rabbit, and cultured on collagen support material for 14 days. 34 rabbits at 22 - 23 days gestational age ( GA) underwent fetoscopy. The entry site was randomly allocated to 4 closure technique study groups: group I, human amnion membrane ( n = 23); group II, collagen foil ( n = 16); group III, collagen plug ( n = 19), and group IV, collagen plug with cultured amnion cells ( n = 19). In all groups membrane access sites were additionally sealed with fibrin sealant, and the myometrium was closed with sutures. Fetal survival, amnion membrane integrity, and the presence of amniotic fluid were evaluated at 30 days GA. Cultures showed good survival in the collagen support material. Increased cellularity, survival and proliferations were observed. The amnion at the access site resealed in 58 - ...
Image:Bacon.jpg,thumb]] With the present interest in fuel cells - devices for directly generating electricity by chemically combining a fuel and oxygen - it is possible to forget that this technology goes back a long way. The first known example was the gas battery, invented by William Robert Grove in the mid-19th century. But perhaps the most interesting figure to pioneer fuel cell technology in the early to mid-twentieth century was Francis Thomas Bacon. Francis Thomas Bacon was a forerunner in fuel cell technology. A descendant of the famous early modern English philosopher and champion of science Francis Bacon, F.T. Bacon was born in Billericay, UK, on 21 December 1904. Trained as an engineer at Trinity College, Cambridge, and employed by steam turbine builder C.A. Parsons in the 1930s, Bacon was fascinated by the ability of fuel cells to directly convert chemical into electrical energy. Although they were then considered a mere scientific curiosity, he became convinced of their ...
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
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Promising Stem Cell Therapy Eliminates Metastatic Cells From the Brain - This shows tagged therapeutic stem cells (green) targeting breast cancer metastases (red) in the brain of a mouse model. Image credit: Khalid Shah/Massachusetts General Hospital #cancer #neurology #science
Researchers from Case Western Reserve University found that the immune system of spinal cord injury patients can be controlled using a family of therapeutic stem cells known as multipotent adult progenitor cells (MAPC),. The MAPCs have the ability to mediate the aggressive nature of macrophages. Importantly, though, the MPAC cells were also able to clear debris and were less disruptive to the healthy tissue.. There was this remarkable neuroprotection with the friendlier macrophages, research leader Jerry Silver, PhD, said in a press release, The spinal cord was just bigger, healthier, with much less tissue damage.. Read more… , Published paper. ...
Emmanuel Tzanakakis is an associate professor in the Department of Chemical and Biological Engineering at Tufts University. He earned his Ph.D. in Chemical Engineering from the University of Minnesota. Tzanakakis did his postdoctoral training at the Stem Cell Institute of the University of Minnesota and at the Diabetes Center of the University of California, San Francisco. His laboratorys research interests are in the area of stem cell engineering, particularly for diabetes and heart disease applications. Implementing a combination of experiment- and computation-based approaches, the overarching goal of his research is the realization of the potential of stem cells in regenerative medicine.. ...
Genostem (acronym for Adult mesenchymal stem cells engineering for connective tissue disorders. From the bench to the bed side) has been an European consortium of 30 teams working together on human bone marrow Mesenchymal Stem Cell (MSC) biological proper- ties and repair capacity. Part of Genostem activity has been dedicated to the study of basic issues on undifferentiated MSCs properties and on signalling pathways leading to the differentiation into 3 of the connective tissue lineages, osteoblastic, chondrocytic and tenocytic. We have evidenced that native bone marrow MSCs and stromal cells, forming the niche of hematopoietic stem cells, were the same cellular entity located abluminally from marrow sinus endothelial cells. We have also shown that culture- amplified, clonogenic and highly-proliferative MSCs were bona fide stem cells, sharing with other stem cell types the major attributes of self-renewal and of multipotential priming to the lineages to which they can differentiate ...
View Stem Cell 2020 Conference Tentative Agenda to know the list of participants who are interested in stem cell engineering, regenerative medicine, tissue engineering, stem cell therapy, biomaterial, and stem cell banking sessions on June 18-19, 2020.
In the April 15th issue of G&D, Dr. Richard Flavell (Yale University) and colleagues identify the c-Cbl protein as a critical repressor of hematopoietic stem cell (HSC) self-renewal. In addition to establishing a key role for protein ubiquitylation in HSC development, this finding posits c-Cbl as a potential target in research into stem cell engineering as well as cell-based leukemia treatments.. Dr. Flavell describes the work as elucidating a novel dimension in our understanding the self-renewal of Hematopoietic stem cells.. Like all stem cell populations, HSC reply upon asymmetric cell division to generate two different daughter cells: one future stem cell, and another cell that will further differentiate into a more specialized cell type. Thus, a balance is struck between the production of new cell types and the renewal of the stem cell pool. However, imbalances between HSC self-renewal and differentiation can lead to hematologic malignancies like leukemia.. Dr. Flavells group discovered ...
The National Institutes of Health (NIH) has awarded nearly $2 million to researchers at the Georgia Institute of Technology and Emory University to develop a new class of therapeutics for treating traumatic injuries and degenerative diseases. The five-year project focuses on developing biomaterials capable of capturing certain molecules from embryonic stem cells and delivering them to wound sites to enhance tissue regeneration in adults. By applying these unique molecules, clinicians may be able to harness the regenerative power of stem cells while avoiding concerns of tumor formation and immune system compatibility associated with most stem cell transplantation approaches. Pre-clinical and clinical evidence strongly suggests that the biomolecules produced by stem cells significantly impact tissue regeneration independent of differentiation into functionally competent cells, said Todd McDevitt, director of the Stem Cell Engineering Center at Georgia Tech and an associate professor in the ...
The goal of the Stem Cell Engineering Research Group (SCERG) is to develop cell production systems for the ex vivo expansion of stem cells and/or their controlled differentiation into specific cell types or microtissues to generate the large numbers of high quality stem/progenitor cell subsets needed for Regenerative Medicine settings, as well as for the development of in vitro models for disease modelling and drug testing ...
Current research projects being undertaken at the Neuromuscular & Regenerative Medicine Unit at the School of Medical Sciences on unraveling signaling mechanisms for Adult Stem Cell Activation and Recruitment are presented. If you are interested in learning about the potential Honours Projects offered in 2011 on Stem Cell Engineering & Biology, please contact Dr Antonio Lee on [email protected] ...
CV Bank and Jobs Database of the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital in Toronto. The SLRI is a Leading Cancer Research facility. The Molecular Biology, Systems Biology, Stem Cells Engineering, Tissue Engineering, Modeling Human Disease, Cancer Genetics, Genome Medicine, Neurodevelopment and Cognitive Function, Womens and Infants Health, Proteomics, Bioinformatics, Human Genome Research, are some of the many research areas in which the Research Institute excels.
CellectCell, a company spawned in labs at the Petit Institute for Bioengineering and Bioscience, is moving steadily toward commercial viability.. We have recently begun pilot production for our initial product, the CellectCell MicroCassette™, and will have beta units in the next few months, says Rebecca Marshall, president and CEO of CellectCell. We are very excited about the progress we have made toward commercializing this novel, label-free cell isolation technology.. The company is the brainchild of co-founders Andrés García and Todd McDevitt, who have deep roots in the Petit Institute and the Georgia Institute of Technology.. García, the Rae S. and Frank H. Neely Chair and Regents Professor in the Woodruff School of Mechanical Engineering, is a longtime faculty researcher at the Petit Institute. McDevitt, former Petit Institute researcher and director of the Stem Cell Engineering Center at Georgia Tech, is now a senior investigator at the Gladstone Institutes and professor in the ...
Sponsor: Johns Hopkins Hospital Ethics Committee and Consultation Service. If youd like, please join librarian Dr. Sue Vazakas at 11:20 a.m. at the Barnes & Noble shuttle stop to ride over together.. Between the Egg and the Sperm: ethics and policy of stem cell engineering ...
Nanocomposite hydrogels (NC gels) are nanomaterial-filled, hydrated, polymeric networks that exhibit higher elasticity and strength relative to traditionally made hydrogels. A range of natural and synthetic polymers are used to design nanocomposite network. By controlling the interactions between nanoparticles and polymer chains, a range of physical, chemical, and biological properties can be engineered. The combination of organic (polymer) and inorganic (clay) structure gives these hydrogels improved physical, chemical, electrical, biological, and swelling/de-swelling properties that cannot be achieved by either material alone. Inspired by flexible biological tissues, researchers incorporate carbon-based, polymeric, ceramic and/or metallic nanomaterials to give these hydrogels superior characteristics like optical properties and stimulus-sensitivity which can potentially be very helpful to medical (especially drug delivery and stem cell engineering) and mechanical fields. Nanocomposite ...
GEORGE CHURCH is professor of genetics at Harvard Medical School and director of the Personal Genome Project, which provides the worlds only open-access information on human genomic, environmental & trait data (GET). His 1984 Harvard PhD included the first methods for direct genome sequencing, molecular multiplexing and barcoding. These led to the first genome sequence (pathogen, Helicobacter pylori) in 1994. His innovations have contributed to nearly all next generation DNA sequencing methods and companies (CGI-BGI, Life, Illumina, Nanopore). This plus his labs work on chip-DNA-synthesis, gene editing and stem cell engineering resulted in founding additional application-based companies spanning fields of medical diagnostics (Knome/PierianDx, Alacris, AbVitro/Juno, Genos, Veritas Genetics) and synthetic biology / therapeutics (Joule, Gen9, Editas, Egenesis, enEvolv, WarpDrive). He has also pioneered new privacy, biosafety, ELSI, environmental and biosecurity policies. He is director of an ...
Upcoming Races within 25 miles of Chicago IL: Jan: Feb: Mar: Apr: May: Jun: Jul: Aug: Sep: Oct: Nov: Dec: Jingle Bell Run - Chicago. Diabetic Birthday Cake Dublin S Ketosis secondly the notion that insulin levels must be Diabetic cats also often have dilute urine unrelated to CKD and the resulting dehydration may also cause increased kidney values. Impact Factor: 3.035 Diabetes & Vascular Disease Research is the first For an alternate route to Diabetes and Vascular Disease Research Online Researches and trials on treatment of diabetes with stem cell engineering are in Type 1 Diabetes Read more articles on Type 1 Diabetes Mellitus CLINICAL PRACTICE UIDELINE: diabetes and jagged edge wounds. As a possible adjunct to insulin-like growth factor 1 and growth Interpretive Handbook. However they can sometimes have a more serious cause. Is drinking alcohol one of them? Can you drink safely and if so how? Learn about alcohol and diabetes. RELATED: Can You Exercise During Pregnancy? What if gestational ...
Michel Sadelain, MD, PhD, Director, Center for Cell Engineering and Gene Transfer and Gene Expression Laboratory, Stephen and Barbara Friedman Chair, Memorial Sloan Kettering Cancer Center (MSK), discusses chimeric antigen receptor (CAR) t-cell therapies.
The cell line engineering segment accounts for the largest share of the Global CRISPR/Cas9 genome editing market, says RNCOS. Genomic engineering in cell lines is a diversified tool for studying gene function, designing diseases models, biopharmaceutical research, drug discovery, and many other applications. For these, the Nuclease-based methods, particularly the CRISPR/Cas9 method, offer an efficient way of controlled gene insertion. A pseudoviral-packaged lentiviral sgRNA and Cas9 construct can be highly efficiently transduced and integrated into virtually any mammalian cells. For instance, CRISPR knockout cells generated using lentiviral CRISPR sgRNA expression vectors are being used to stably introduce and integrate an appropriate sgRNA and Cas9 nuclease.. The cell engineering application has generated the highest revenue for CRISPR market. One of the major factors attributing the growth are scalability of CRISPR/Cas9 in modifying the multiple sites within the mammalian genome providing a ...
LONDON, December 5, 2012 /PRNewswire/ --. - Market demands to reduce manufacturing costs require better Cell culture processes. According to further research conducted for the annual 2013 Cell Line Development & Engineering conference in Vienna next February, major developments in cell culture systems have given biotechs and pharmaceutical companies more flexibility to scale up cells to a high manufacturing quality. Cell engineering tools have enabled the production of high-performing cell lines and this has only been possible through improvements in cell culture media.. To best accommodate for these new developments, Informa Life Sciences have expanded the programme to cover the latest in cell line development strategies and improvements in cell culture systems. Speaker Alison Porter, Head of Cell Line Development in the Mammalian Cell Culture group at Fujifilm Diosynth Biotechnologies (FFDB) clarifies how With cell line construction on the critical path for first in human studies, it is ...
Mustang Dynamometer and Mustang Advanced Engineering have been designing and developing world class automotive testing systems for over 35 years. Mustang specializes in chassis dynamometers, engine dynamometers, transmission dynos and tow dynes. We also offer custom test cell engineering for any automotive testing needs.
Peter Donovan, received his Ph.D in Cell Biology from University College, London and carried out postdoctoral studies at St. Georges Medical School in London where he began his studies on germ cell development. He established his own independent laboratory at the National Cancer Institute where his laboratory pioneered the development of pluripotent stem cells from germ cells in mice and, with John Gearhart, developed the same cell type from human germ cells. He then moved to the Kimmel Cancer Center in Philadelphia before being recruited to become co-director of the Stem Cell Program in the Institute for Cell Engineering at Johns Hopkins University. He moved to UC Irvine in 2006 and was Co-Director of the Sue and Bill Gross Stem Cell Research Center until 2010 and then Director until 2013. Dr. Donovan is the Program Director for the UC Irvine Training Grant in Stem Cell Biology and the Principle Investigator for the UC Irvine Shared Research Laboratory and Stem Cell Techniques Course, both ...
Under the terms of the agreement, Vor obtains non-exclusive clinical and commercial use rights to MaxCytes Flow Electroporation® technology and ExPERT™ platform to develop up to five engineered cell therapies, including VOR33, Vors lead eHSC candidate, which is in development for acute myeloid leukemia (AML). In return, MaxCyte will receive undisclosed development and approval milestones and sales-based payments in addition to other licensing fees.. Vor will use MaxCytes cell engineering platform to deliver its gene editing machinery into hematopoietic stem cells to remove biologically redundant cell surface proteins that are also expressed on blood cancer cells. Once the eHSCs are transplanted into a cancer patient, these cells are effectively hidden from complementary targeted therapies that target the relevant protein, while diseased cells are left vulnerable to attack. Vors approach thereby could unleash the potential of targeted therapies by broadening the therapeutic window and ...
I am pleased to enter into this collaboration with Universal Cells for a novel cell therapy using their proprietary Universal Donor Cell technology based on gene editing by rAAV (recombinant Adeno-Associated Virus) and cell engineering of pluripotent stem cells, said Yoshitsugu Shitaka, Ph.D., president of AIRM. This is definitely an important step forward in developing a potential new option as an innovative cell therapy to treat devastating diseases with high unmet medical needs.. While the research will be conducted jointly by AIRM and Universal Cells, Astellas will lead and fully fund the development program and will obtain worldwide rights for commercialization. In consideration for the collaboration and grant of rights, under the terms of the agreement, Universal Cells is eligible to receive up to $9 million in a combination of an upfront payment and research milestones. Universal Cells is also eligible to receive research funding and further clinical development and regulatory ...
The Austrian Centre of Industrial Biotechnology (acib) is a research institution with the expertise of 200 employees. We have a wealth of experience in European projects (from FP7 to H2020, but also IMI, ERA-NET, etc.) and have been valued as a very reliable and innovative partner.. We can assist you in all fields of industrial biotechnology such as:. - Biocatalaysis. - Protein Engineering. - Synthetic Biology. - Cell Engineering (e.g. E. coli, S. cerevisiae, P. pastoris, T. reesei, A. niger, CHO-cells, etc.). - Bioinformatics. - Structural Biology. - Metabolic Modeling. - Bioprocess Engineering. - Environmental Biotechnology. - (Bio)polymers and -materials. - …. For futher information, please, contact:. Martin Trinker. Director Business Development &Fundraising at ACIB GmbH. Email: [email protected] phone: +43 316 873 9316. Publicado por europa en marzo 7, 2017. ...
A better understanding of the cell-fate transitions that occur in complex cellular ecosystems in normal development and disease could inform cell engineering efforts and lead to improved therapies. However, a major challenge is to simultaneously identify new cell states, and their transitions, to elucidate the gene expression dynamics governing cell-type diversification. Here, we present CellRouter, a multifaceted single-cell analysis platform that identifies complex cell-state transition trajectories by using flow networks to explore the subpopulation structure of multi-dimensional, single-cell omics data. We demonstrate its versatility by applying CellRouter to single-cell RNA sequencing data sets to reconstruct cell-state transition trajectories during hematopoietic stem and progenitor cell (HSPC) differentiation to the erythroid, myeloid and lymphoid lineages, as well as during re-specification of cell identity by cellular reprogramming of monocytes and B-cells to HSPCs. CellRouter opens previously
The polymer scaffolds will be produced by Professors Steve Howdle and Kevin Shakesheff, experts in cells and chemistry engineering in the University of Nottingham. Professor Howdle clarifies: Building upon solid collaborations with cells engineering experts, this fresh grant will allow experts at Nottingham to consider their components nearer to the clinic. This could have got great benefits for sufferers, and also provide a significant price saving for health care authorities; but we have to verify and build upon our preliminary data first. A major area of the function at Nottingham calls for scaling up the supercritical liquid processing apparatus to develop larger and even more uniform batches of polymer scaffolds for assessment.A mechanism to induce senescence in particular nerve cells could delay or remove starting point of the diseases. Similarly, a disease like cancer, which thrives and spreads through unregulated replication of cancer cells, may be fought through induced senescence. This ...
Scientists and transplant clinicians at the Ansary Stem Cell Institute at Weill Cornell Medical College and the Center for Cell Engineering at Memorial Sloan Kettering Cancer Center have been awarded a $15.7 million, four-year research grant from the New York State Stem Cell Science Program (NYSTEM).. The scientists will translate their approach to manipulate hematopoietic stem cells to cure acquired and inherited blood disorders. For many patients with such blood diseases, including sickle cell disease, the only hope for a cure requires transplanting normal blood stem cells.. But in many instances suitable blood stem cells cannot be found or there are ...
Peking University, Nov. 28, 2013: Chinese scientists for the first time were elected as the editors for magazine Cell: Professor Deng Hongkui from PKU and Professor Cao Xuetao from Chinese Academy of Medical Sciences.. Cell, founded in 1974, is widely recognized as the top-notch magazine in the academia of Life Sciences. All of its editors are first-class scientists and academic leaders. Deng Hongkui is a renowned cell biologist. In 1995, he got the Ph.D degree at University of California, Los Angeles (UCLA). After that, he did postdoctoral research at New York University (NYU). After returning to China in April 2001, Professor Deng established Cell Differentiation and Cell Engineering Laboratory at School of Life Sciences, PKU and worked on cell differentiation, stem cell biology and regenerative medicine research. Professor Deng has published many essays on Cell, Nature and Science magazines. Cao Xuetao is a famous immunologist. He was elected as the academician of Chinese Academy of ...
Nanokicking Stem Cells Offers Cheaper And Easier Way To Grow New Bone Researchers in Scotland have developed a new method that coaxes stem cells into growing new bone by nanokicking them 1,000 times per second. They suggest the technology is cheaper and easier to implement than the current methods and opens the door to new ways of treating bone conditions like stress fractures, spinal traumas and osteoporosis. Matt Dalby from the Centre for Cell Engineering at the University of
Eukaryotic cell lines, including Chinese hamster ovary cells, yeast, and insect cells, are invaluable hosts for the production of many recombinant proteins. With the advent of genomic resources, one can now leverage genome-scale computational modeling of cellular pathways to rationally engineer eukaryotic host cells. Genome-scale models of metabolism include all known biochemical reactions occurring in a specific cell. By describing these mathematically and using tools such as flux balance analysis, the models can simulate cell physiology and provide targets for cell engineering that could lead to enhanced cell viability, titer, and productivity. Here we review examples in which metabolic models in eukaryotic cell cultures have been used to rationally select targets for genetic modification, improve cellular metabolic capabilities, design media supplementation, and interpret high-throughput omics data. As more comprehensive models of metabolism and other cellular processes are developed for ...
Tissue engineering. Laboratory technicians gloved hands hold petri dishes containing cultures of human tendon on smart bandages. Cut tendons lie on strips of synthetic bandage. The culture solution also contains human tendon cells. Smart bandage technology enables rapid regrowth and joining of damaged body tissues, like tendon or bone. Tiny grooves etched in the bandage direct the growth of tendon cells. Placed between broken ends of a tendon the bandage speeds healing and joining, after which the bandage biodegrades. This technology may provide templates for hip replace- ments & other cell engineering projects. Research conducted at the University of Glasgow, Scotland. - Stock Image M580/0106
Dr. Rivière received her Ph.D. in Cellular and Molecular Biology from the University of Paris. She initiated her graduate studies at the Institut Curie in Paris and completed her thesis in the laboratory of Dr. Mulligan at the Whitehead Institute in Cambridge, MA. During this time, she developed novel retroviral vectors for in vivo long-term expression of transgenes in hematopoietic cells using MFG/SFG-based retroviral vectors that are widely used in clinical studies for the treatment of genetic and acquired disorders.. She subsequently worked as a post-doctoral fellow in the laboratory of Dr. Littman at New York University, NY. Dr. Rivière joined the faculty of Memorial Sloan-Kettering Cancer Center in 1999. She is currently the Director of the Michael G. Harris Cell Therapy and Cell Engineering Facility where she investigates the genetic modification of hematopoietic cells to increase or retarget the immune response against tumors. ...
Host tropism is the infection specificity of certain pathogens to particular hosts and host tissues. This type of tropism explains why most pathogens are only capable of infecting a limited range of host organisms. Researchers can classify pathogenic organisms by the range of species and cell types that they exhibit host tropism for. For instance, pathogens that are able to infect a wide range of hosts and tissues are said to be amphotropic. Ecotropic pathogens, on the other hand, are only capable of infecting a narrow range of hosts and host tissue. Knowledge of a pathogens host specificity allows professionals in the research and medical industries to model pathogenesis and develop vaccines, medication, and preventative measures to fight against infection. Methods such as cell engineering, direct engineering and assisted evolution of host-adapted pathogens, and genome-wide genetic screens are currently being used by researchers to better understand the host range of a variety of different ...
European Cells & Materials Journal - Open and Free Access - The Official Research Journal of AOCMF, AOTrauma, European Orthopaedic Research Society (EORS), Swiss Society for Biomaterials (SSB) and Tissue & Cell Engineering Society (TCES)
When concentrating on the ethical dilemmas included, a conservative method is required. Thus when the first problem is presented, one should view each stem mobile from the perspective that living begins right now of conception portrayal the embryo a living human being despite differing opinions. While Jewish leaders have a neutral see since the Hebrew word golem or unformed material is vague concerning the beginnings of life, Christianity based on the incarnation of Christ.. Advanced Cell Engineering stated. Yet authorities argue that the possible does occur introducing an ethical predicament that will only be resolved through medical research. Accordingly it is critical that researchers who presently get just one cell from a human blastomere for PGD (preimplantation genetic diagnosis) all through in vitro fertilization to try for genetic disorders, replicate that cell prior to screening and perform research to find out when it certainly can make an embryo and therefore a life, on its own. ...
In 2010 I received my Bachelor in Biotechnology and in 2012 my Master degree in Biomedical Biotechnology from Universitat Politecnica de Valencia in Spain. Between 2012 and 2017 I pursued a PhD in Biomedical Biotechnology at the Universitat Politecnica de Valencia, obtained with European mention and honors. During my PhD my research activity was complemented by several internships, at the Centre for Cell Engineering at the University of Glasgow, 2012; a Marie-Curie-IAPP Program Secodment in Germany, 2013; and The Biomaterial Immuno-Engineering Lab at the University of Florida, 2014. I worked on investigating the role of fibronectin and growth factors on mediating cell-material interactions towards bone differentiation.. In 2017, I started as a Research Assistant in Professor Matthew Dalby reseach group where I have been working on growth factors and material-based strategies to engineer tissue repair and regeneration and with my own side project in 2019 on the discovery of metabolites involved ...
"Optogenetic control of cell function using engineered photoreceptors". Biology of the Cell. 105 (2): 59-72. doi:10.1111/boc. ... Optogenetic control of cell dynamics". Current Opinion in Cell Biology, Themed Issue : Cell Dynamics. Elsevier Ltd. 66: 1-10. ... December 1996). "Subregion- and cell type-restricted gene knockout in mouse brain". Cell. 87 (7): 1317-26. doi:10.1016/S0092- ... Tischer D, Weiner OD (August 2014). "Illuminating cell signalling with optogenetic tools". Nature Reviews. Molecular Cell ...
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"A Cell-Surface Membrane Protein Signature for Glioblastoma". Cell Systems. 4 (5): 516-529.e7. doi:10.1016/j.cels.2017.03.004. ... His father was an electrical engineer, and his mother had a degree in home economics. Hood was one of four children, including ... Cell Genet. 39 (4): 246-9. doi:10.1159/000132152. PMID 2414074. Walters, LeRoy; Palmer, Julie Gage (1996). The ethics of human ... Leroy Hood is a member of the National Academy of Sciences (NAS, 1982), the National Academy of Engineering (2007), and the ...
Pyle, A. M.; Marcia, M. (2012). "Visualizing Group II Intron Catalysis through the Stages of Splicing". Cell. 151 (3): 497-507 ... "Targeting RNA's tertiary structure". Chemical & Engineering News. Retrieved 2019-03-01. Pyle, Anna Marie; Zandt, Michael C. Van ... and also how ATP-dependent enzymes in the cell recognize and remodel RNA. Specifically, she was successful in crystallizing and ...
"C&EN's 2019 10 Start-Ups to Watch". Chemical & Engineering News. Retrieved 2020-08-27. "Cell Press: Cell Chemical Biology". www ... Cell. 140 (1): 49-61. doi:10.1016/j.cell.2009.11.027. ISSN 1097-4172. PMC 2885975. PMID 20079333. Nomura, Daniel K.; Morrison, ... Nomura is a co-founder of Frontier Medicines and an associate editor of Cell Chemical Biology. In 2020, in response to the ... Nomura received his BA in Molecular and Cell Biology and PhD in Molecular Toxicology from UC Berkeley, studying under the ...
... protein engineering; drug delivery; molecular biology; structural biology; cell biology; glycobiology; molecular imaging and in ... Research in the Davis laboratory has been funded by the Engineering and Physical Sciences Research Council, the Biotechnology ... the creation of synthetic cells and viruses; and in vivo chemistry. These have enabled associated mechanistic details of ...
Localization of proteins in yeast and animal cells Localization of proteins in yeast and animal cells: EVI5L TMHMM:Prediction ... Protein Engineering, Design & Selection. 17 (6): 527-36. doi:10.1093/protein/gzh062. PMID 15314210. Sano H, Eguez L, Teruel MN ... This is attributed to the requirement of RAB23 in the differentiation of cardiac progenitor cells. RAB23 is required for normal ... Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and ...
This gene has been commonly found mutated in gastric cancers, ovarian clear cell carcinoma, and pancreatic cancer. In breast ... "Tissue Regeneration Promoted through Gene Suppression". Genetic Engineering & Biotechnology News. March 2016. Kato H, Tjernberg ... August 2017). "Genomic Evolution of Breast Cancer Metastasis and Relapse". Cancer Cell. 32 (2): 169-184.e7. doi:10.1016/j.ccell ... Cell. 113 (7): 905-17. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248. ARID1A+protein,+human at the US National Library of ...
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... is a UK biotechnology company that uses a human cell microarray system to identify cell surface receptors for ... "Removing the receptor deconvolution bottleneck". Genetic Engineering and Biotechnology News. 33 (14). August 2013. Turner L, ... The human cell microarray tool developed by Retrogenix utilises a library of expression vectors containing open reading frames ... The cell microarray technology identifies targets and receptors that are important in the understanding of normal biological ...
... inhibits T cells cytotoxic function, and promotes T cell apoptosis. HIF-1α also induces TAMs to suppress T cell function ... Nature Biomedical Engineering. 2 (8): 578-588. doi:10.1038/s41551-018-0236-8. PMID 31015631. Ruffell B, Coussens LM (April 2015 ... these factors limit T-cell proliferation and upregulate expansion of regulatory T cells, allowing tumor cells to evade immune ... TAMs affect most aspects of tumor cell biology and drive pathological phenomena including tumor cell proliferation, tumor ...
"Speaker: Cell Symposia: Metabolites as Signalling Molecules". www.cell-symposia.com. Retrieved 2019-12-01. "Jason Locasale , ... "Mice fed a low-methionine diet respond better to cancer treatments". Chemical & Engineering News. Retrieved 2019-12-08. "HOME ... He serves on the editorial boards for a number of journals including PLoS Biology, Oncotarget, and Cell Stress, and has served ... "Editorial Board". Cell Stress. 1970-01-01. ISSN 2523-0204. "Deciphering cancer: The intersection of epigenetics, metabolism, ...
Neri, D.; Petrul, H.; Roncucci, G. (August 1995). "Engineering recombinant antibodies for immunotherapy". Cell Biophysics. 27 ( ... The cultivation of CHO cells for recombinant antibody expression is a popular strategy for antibody producers since the cell ... "Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts". Blood Cancer Journal. 6 ( ... then they are transferred to a cell culture in the process called transfection and once the cell culture produces the desired ...
Inhibition of proteasome-mediated proteolysis results in a build-up of polyubiquitinated proteins, which may cause cell cycle ... "Carfilzomib: From Discovery To Drug". Chemical & Engineering News. 2012-08-27. Retrieved 2013-07-30. "Onyx multiple myeloma ...
Cell Physiology. 302 (8): C1109-18. doi:10.1152/ajpcell.00369.2011. PMC 3330730. PMID 22173868. Dolan JM, Meng H, Singh S, ... Annals of Biomedical Engineering. 39 (6): 1620-31. doi:10.1007/s10439-011-0267-8. PMC 4809045. PMID 21312062. Hunt BJ, Jurd KM ... It is most characterized by an increase in interactions with white blood cells (leukocytes), and it is associated with the ... Dolan JM, Sim FJ, Meng H, Kolega J (April 2012). "Endothelial cells express a unique transcriptional profile under very high ...
"Contacts , Cell Engineering". www.celleng.com.au. Retrieved 6 January 2016. This Wikipedia article was originally based on "The ...
Nanoparticle-Mediated Genetic Engineering of Plants. In Molecular Plant (Vol. 12, Issue 8, pp. 1037-1040). Cell Press. doi: ... Nanoparticle-Mediated Genetic Engineering of Plants. In Molecular Plant (Vol. 12, Issue 8, pp. 1037-1040). Cell Press. doi: ... carrying genetic information through the cell walls and membranes of cells to impart genetic transformation. As previously ... Due to the significantly reduced size of the particle being launched into the cell, the impact can be minimized, while offering ...
Cell. 31 (2): 294-301. doi:10.1016/j.molcel.2008.06.016. PMC 2535758. PMID 18657511. Carroll D (2011). "Genome engineering with ... After editing the stem cell genome, the cells could be expanded in culture and reinserted into the patient to produce ... Several groups are also developing other types of engineered nucleases including engineered homing endonucleases and nucleases ... custom-designed molecular scissors for genome engineering of plant and mammalian cells". Nucleic Acids Res. 33 (18): 5978-5990 ...
Cell. 2020 Y. Shin, C.P. Brangwynne. Liquid phase condensation in cell physiology and disease. Science, 2017. Y. Shin, Y-C. ... Clifford Brangwynne is a professor of chemical and biological engineering at Princeton University and a 2018 recipient of the ... Cell, 2016. Sanders DW, Kedersha N, Lee DSW, Strom AR, Drake V, Riback JA, Bracha D, Eeftens JM, Iwanicki A, Wang A, Wei MT, ... Cell, 2018. 2012 NIH New Innovator Award, National Institute of Health 2014 Sloan Research Fellow, Sloan Foundation 2015 ASCB ...
... cells with well defined genetic circuitry can be engineered. It is widely believed that if a proper toolbox of parts is ... synthetic cells can be developed implementing only the pathways necessary for cell survival reproduction. From this cell, to be ... Once the cells are induced, it is difficult to remove IPTG from the cells and therefore it is difficult to stop expression. Two ... Cell. 137 (7): 1272-1281. doi:10.1016/j.cell.2009.04.048. PMC 2775486. PMID 19563759. Cheng, Allen A.; Lu, Timothy K. (2012-01- ...
It was characterised as a system for ensuring that all daughter cells contained a copy of the plasmid encoding the vapBC locus ... Protein Engineering Design and Selection. 24 (1-2): 33-40. doi:10.1093/protein/gzq081. PMID 21036780. Gómez, FA; Cárdenas, C; ... Ogura, T; Hiraga, S (Aug 1983). "Mini-F plasmid genes that couple host cell division to plasmid proliferation". Proceedings of ... Cell Research. 14 (3): 208-16. doi:10.1038/sj.cr.7290221. PMID 15225414. Arcus, V. L.; McKenzie, J. L.; Robson, J.; Cook, G. M ...
Another project involves engineering beneficial probiotics with the ability to detect or treat cancer cells. Bhatia holds a ... Bhatia, S. N.; Underhill, G. H.; Zaret, K. S.; Fox, I. J. (16 July 2014). "Cell and tissue engineering for liver disease". ... She adapted ideas from computer chip design and engineering to the microfabrication of a substrate for liver cells. She ... Bhatia also used co-cultures of more than one cell type to prevent dedifferentiation of the liver cells, building on the work ...
Crews is a former Editor of Cell Chemical Biology and the Executive Director of the Yale Center for Molecular Discovery. His ... 90 Issue 35 , Chemical & Engineering News". Cen.acs.org. 2012-08-27. Retrieved 2016-05-05. CS1 maint: discouraged parameter ( ... CS1 maint: discouraged parameter (link) "Scientist wants to hijack cells' tiny garbage trucks to fight cancer". Boston Globe. ... 94 Issue 3 , Chemical & Engineering News". Cen.acs.org. 2016-01-18. Retrieved 2016-05-05. CS1 maint: discouraged parameter ( ...
It is used as the main component of secondary frequency references (rubidium oscillators) in cell site transmitters and other ... "Cesium and Rubidium Hit Market". Chemical & Engineering News. 37 (22): 50-56. 1959. doi:10.1021/cen-v037n022.p050. Kirchhoff, G ... Such spin-polarized 3He cells are useful for neutron polarization measurements and for producing polarized neutron beams for ... ISBN 978-0-7923-8594-3. Marton, L. (1977-01-01). "Rubidium Vapor Cell". Advances in electronics and electron physics. ISBN 978- ...
... to identify a cell as potentially redundant). Basic policing works on a cell by cell basis, but this is sub-optimal for ... Distributed Systems Engineering. 4 (2): 78-86. doi:10.1088/0967-1846/4/2/002. S2CID 2837224. Cisco Systems Guide to ATM ... the current and subsequent cells are dropped until a cell with no header errors is found. A UNI cell reserves the GFC field for ... Which AAL is in use for a given cell is not encoded in the cell. Instead, it is negotiated by or configured at the endpoints on ...
Chou KC, Shen HB (2008-01-01). "Cell-PLoc: a package of Web servers for predicting subcellular localization of proteins in ... Protein Engineering, Design & Selection. 17 (6): 527-36. doi:10.1093/protein/gzh062. PMID 15314210. King, Brian R; Guda, ... Shao W, Liu M, Zhang D (January 2016). "Human cell structure-driven model construction for predicting protein subcellular ... Woodcroft BJ, Hammond L, Stow JL, Hamilton NA (November 2009). "Automated organelle-based colocalization in whole-cell imaging ...
As only a single cell is transformed with genetic material, the organism must be regenerated from that single cell. In plants ... Genetically Engineered Crops: Experiences and Prospects. The National Academies of Sciences, Engineering, and Medicine (US). p ... DNA is generally inserted into animal cells using microinjection, where it can be injected through the cell's nuclear envelope ... It has been engineered with three genes that biosynthesise beta-carotene, a precursor of vitamin A, in the edible parts of rice ...
Stem cell engineering : principles and applications. Artmann, Gerhard M., Minger, Stephen., Hescheler, J. K.-J. (Jürgen Karl- ... Artmann, Gerhard M.; Minger, Stephen; Hescheler, Jürgen (2011). Stem Cell Engineering , SpringerLink. doi:10.1007/978-3-642- ... Rylie Green is an Australian biomedical engineer who is a Reader at Imperial College London. She works on bioactive conducting ... She received her PhD in neural interfaces from the School of Biomedical Engineering, University of New South Wales (UNSW) in ...
Hamming codes are only suitable for more reliable single-level cell (SLC) NAND. Denser multi-level cell (MLC) NAND requires ... Glover, Neal; Dudley, Trent (1990). "Practical Error Correction Design For Engineers" (Revision 1.1, 2nd ed.). CO, USA: Cirrus ... "Error Correction Code in Single Level Cell NAND Flash memories" 16 February 2007 ...
Sharia and Social Engineering: p 143, R. Michael Feener - 2013 *^ FOOD & EATING IN MEDIEVAL EUROPE - Page 73, Joel T. Rosenthal ... The brain detects insulin in the blood, which indicates that nutrients are being absorbed by cells and a person is getting full ... When the glucose levels of cells drop (glucoprivation), the body starts to produce the feeling of hunger. The body also ...
Keratinocytes engineered to not express alpha-catenin have disrupted cell adhesion and activated NF-κB. A tumor cell line with ... F9 embryonal carcinoma cells are similar to the P19 cells shown in Figure 1 and normally have cell-to-cell adhesion mediated by ... providing the cell with a means of stable cell adhesion. However, decreases in this adhesion ability of the cell has been ... "Knockdown of Sec6 improves cell-cell adhesion by increasing α-E-catenin in oral cancer cells". FEBS Lett. 586 (6): 924-33. doi: ...
Cells are homogenised in a blender and filtered to remove debris. *The homogenised sample is placed in an ultracentrifuge and ... Harrison, Roger G., Todd, Paul, Rudge, Scott R., Petrides D.P. Bioseparations Science and Engineering. Oxford University Press ... General method of fractionation: Cell sample is stored in a suspension which is: *Buffered - neutral pH, preventing damage to ... This method is commonly used to separate organelles and membranes found in cells. Organelles generally differ from each other ...
The cells met to read Marxist texts and hold self-criticism sessions.[51] Sâr joined a cell that met on the rue Lacepède; his ... Sâr passed his brevet and secured one of five scholarships allowing him to travel to France to study at one of its engineering ... They established party cells, emphasising the recruitment of small numbers of dedicated members, and organized political ... a Marxist-Leninist organisation arranged in a clandestine cell system.[50] ...
D.Zhang et al., Functional Electrical Stimulation in Rehabilitation Engineering: A survey, Nenyang technological University, ... "satellite cells" which help to regenerate skeletal muscle fibers, and a decrease in sensitivity to or the availability of ... accompanied by a smaller number and size of the muscle cells as well as lower protein content. In humans, prolonged periods of ... critical secreted growth factors which are necessary to maintain muscle mass and satellite cell survival. In addition to the ...
The moonlit sky is not perceived as blue, however, because at low light levels human vision comes mainly from rod cells that do ... Rajagopal, K. (2008) Textbook on Engineering Physics, PHI, New Delhi, part I, Ch. 3, ISBN 8120336658 ...
They are a class of cell cycle-specific cytotoxic drugs that work by inhibiting the ability of cancer cells to divide: Acting ... Molecular Engineering. 1 (2): 153-160. doi:10.1007/BF00420051.. ... They block beta-tubulin polymerization in a dividing cell. ... The newer semi-synthetic chemotherapeutic agent vinorelbine is used in the treatment of non-small-cell lung cancer[7][9] and is ... "Safety and efficacy of vinorelbine in the treatment of non-small cell lung cancer". Clinical Medicine Insights: Oncology. 5 ...
Translucent Mylar film, as wide as 48" and in up to 12' in length, found widespread use as a non-dimensional engineering ... Films in annular ring mounts on gas-tight cells, will readily deform into spherical mirrors. Photomultiplier cosmic-ray ... Before the widespread adoption of CAD, engineering drawings or architectural drawings were plotted onto sheets of boPET film, ... This allows production and engineering staff to lay manufactured parts directly over or under the drawing film in order to ...
1983). A History of Engineering and Science in the Bell System, Physical Science (1925-1980). AT&T Bell Laboratories. p. 102.. ... Low operating voltages compatible with batteries of only a few cells.. *Circuits with greater energy efficiency are usually ... Joint Electron Device Engineering Council (JEDEC)[edit]. The American JEDEC part numbering scheme evolved in the 1960s. The ... Institute of Electrical and Electronics Engineers. Retrieved July 4, 2019.. *^ "The Breakthrough Advantage for FPGAs with Tri- ...
"Challenges in Cardiac Tissue Engineering". Tissue Engineering Part B: Reviews 16 (2): 169-187. doi:10.1089/ten.teb.2009.0352. ... Gyda bodau dynol, mae Cell goch y gwaed yn cael eu cynhyrchu gan rhan tu mewn i'r mer esgyrn ym mhen esgyrn hir mewn proses a ... macroffabau, sy'n cyfrannu'n sylweddol at gynhyrchiad Cell goch y gwaed, gan eu bod yn mynd a Haearn ar gyfer cynhyrchiad ... Mae'n hysbys fod MSCau yn addasu, yn vitro neu'n vivo, i osteoblastau, chondroctyeau (cell cartilag), have been shown to ...
Basu et al (2014) Intestinal cell proliferation and senescence is regulated by receptor guanylyl cyclase C and p21 J. Biol. ... "Intensification of Research in High Priority Area (IRHPA): Science and Engineering Research Board, Established through an Act ... the Alliance for Cell Signalling[20] (1997-present), the TB Structural Genomics Consortium, the American Society for ... Bangalore and Co-chair of the Centre for Biosystems Science and Engineering,[2] Indian Institute of Science. Over the course of ...
Outer hair cells serve as acoustic amplifiers for stimulation of the inner hair cells. Outer hair cells respond primarily to ... Many musicians, audio engineers, and scientists that work in industry are exploring ways to mitigate the effects of listening ... "J. Cell Biol. 164 (6): 887-97. doi:10.1083/jcb.200310055. PMC 2172292. PMID 15024034.. ... The stereocilia (hair cells) of the inner ear can become subjected to bending from loud noises. Because they are not ...
"Engineering and Technology Magazine. London: The Institution of Engineering and Technology. Retrieved 3 January 2015.. ... The German Type 214 submarine employs advanced polymer electrolyte membrane fuel cells that assist in delivering it comparable ... http://www.industry.usa.siemens.com/verticals/us/en/marine-shipbuilding/brochures/Documents/SINAVY-PEM-Fuel-Cell-en.pdf ...
National Research Council; Division on Engineering and Physical Sciences; Energy Engineering Board; Commission on Engineering ... In medicine, this era brought innovations such as open-heart surgery and later stem cell therapy along with new medications and ... Science, engineering and technology. Antoine Lavoisier conducting an experiment with combustion generated by amplified sun ... "Science and Engineering Indicators 2002. National Science Foundation. Archived from the original on 18 August 2005. Retrieved 7 ...
Inggris) Scientists are synthetically engineering E. coli that can target and kill cancer cells ... Inggris) Scientists engineer bacteria to create living photographs. *( ...
The formation of the ascospores occurs through the conjugation of the haploid cells preceding the formation of the ascus.[8] ... Bioprocess and Biosystems Engineering. 38 (6): 1143-1155. doi:10.1007/s00449-015-1356-0. PMID 25614449.. ... the yeast cells appear globose, ellipsoidal or cylindrical, 2-6 x 3-11 μm in size.[6] In a glucose-yeast extract broth, K. ... Alternatively, ascosporogensis can arise directly from diploid cells.[8] Each ascus contains 1-4 ascospores.[8] The ploidy of K ...
The skin consists of a thin outer epidermis with mucous cells and sensory cells, and a connective tissue dermis consisting ... IEEE Engineering in Medicine and Biology Society. 25 (3): 40-56. doi:10.1109/MEMB.2006.1636351.. ... Other colour-changing cells are reflective iridophores and white leucophores.[93] This colour-changing ability is also used to ... The lens is suspended behind the pupil and photoreceptive retinal cells cover the back of the eye. The pupil can be adjusted in ...
... the complex was engineered and built by CDA Engineering and Siemens Engineering.[25] ... In his speech he used words such as "cell" and "metabolism" in relation to urban design. The Metabolist movement grew out of ... In 1963, he was promoted to professor of the Department of Urban Engineering. His students included Sachio Otani, Kisho ...
Biomedical Engineering is a field dealing with the application of engineering principles to medical practice. ... discovered by Paul Ehrlich in 1908 after he observed that bacteria took up toxic dyes that human cells did not. The first major ...
"The Plant Cell. 3 (11): 1187-1193. doi:10.2307/3869226. JSTOR 3869226. PMC 160085 . PMID 1821764.. ... A genetically modified tomato, or transgenic tomato, is a tomato that has had its genes modified, using genetic engineering. ... "Plant Cell Reports. 12: 644-647. doi:10.1007/bf00232816.. CS1 maint: Multiple names: authors list (link) ... "Fruit Cell Wall Proteins Help Fungus Turn Tomatoes From Ripe To Rotten". Science Daily. Jan 31, 2008. Retrieved 29 August 2010. ...
One study, however, did make use of human neural stem cells grown into a network to control a robotic actuator. These cells ... Artificial life Artificial neural networks Brain-computer interface CoDi Cybernetics Neural ensemble Neural engineering ... Harvesting neural stem cells requires sacrificing the developing fetus, a process considered too costly to perform on many ... Like most cell cultures, neuron cultures are highly susceptible to infection. They are also susceptible to hyperosmolality from ...
Multiple tornadoes produced by the same storm cell are referred to as a "tornado family".[21] Several tornadoes are sometimes ... The Enhanced Fujita (EF) Scale was an update to the older Fujita scale, by expert elicitation, using engineered wind estimates ... Tornadic storms do not contain more lightning than other storms and some tornadic cells never produce lightning at all. More ...
... engineering students and engineers from the Ford Motor Company and will seek to break the land speed record for hydrogen cell ... Ohio State's faculty currently includes 21 members of the National Academy of Sciences or National Academy of Engineering, four ... A team of engineering students from the university's "Center for Automotive Research-Intelligent Transportation" (CAR-IT) ...
At the same time, Michael confronts Leila over the call made using the stolen cell phone. He then kills Leila's handler as he ... Jason Ritter as Sean Walker - a software engineer who becomes involved in a government conspiracy when his would-be fiancée, ... At the end, Leila manages to contact Sean using a stolen cell phone and informs him of Sophia's plan. ...
Potassium is the major cation (positive ion) inside animal cells,[223] while sodium is the major cation outside animal cells.[ ... "Cesium and Rubidium Hit Market". Chemical & Engineering News. 37 (22): 50-56. 1959. doi:10.1021/cen-v037n022.p050.. ... The balance between potassium and sodium is maintained by ion transporter proteins in the cell membrane.[231] The cell membrane ... Unit cell ball-and-stick model of lithium nitride.[118] On the basis of size a tetrahedral structure would be expected, but ...
The pollen tube is produced by the single vegetative cell in the pollen grain, which passes its cytoplasm, nucleus and two ... natural or engineered) from other types of corn. The popcorn remains free to donate its genes via its own pollen to other types ... this is due to a change of shape of existing cells rather than their replication. The elongation progresses at 1.5 inches per ... through which the sperm cells (the gametes) pass to join the female gametophyte within the ovule. ...
... and antireflective coatings on solar cells.[1] ... "Southwest Museum of Engineering, Communications and Computation ...
158 Cells of the immune system, such as macrophages, mast cells, plasma cells and eosinophils are found scattered in loose ... 2008). "Monitoring Tissue Engineering Using Magnetic Resonance Imaging". Journal of Bioscience and Bioengineering. 106 (6): 515 ... The cells of connective tissue include fibroblasts, adipocytes, macrophages, mast cells and leucocytes. ... Cells are spread through an extracellular fluid.. *Ground substance - A clear, colorless, and viscous fluid containing ...
"Engineering metrology toolbox. National Institute of Standards and Technology (NIST). Archived from the original on 2014-01-11 ... A differential interference contrast microscopy image of yeast cells. Unstained biological structures appear mostly transparent ...
Results of a Clinical Trial of Vaccination with Irradiated Autologous Prostate Tumor Cells Engineered to Secrete Granulocyte- ... LNCaP PCA cells (43) , PC-3 PCA cells (44) , DU 145 PCA cells (45) , A549 lung carcinoma cells (46) , LS-174T colon carcinoma ... B, Lane 1, PC-3 PCA cells; Lane 2, LNCaP PCA cells; Lane 3, A549 lung carcinoma cells; Lane 4, LS-174T colon carcinoma cells; ... cells (47) , KLE endometrial carcinoma cells (48) , Jurkat T-cell leukemia cells (49) , and MDA-MB-435 breast carcinoma cells ( ...
The potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized ... bioreactors cell expansion differentiation drug discovery embryonic stem cell growth stem cell growth ... stem cells and drug discovery, screening platforms. Stem Cell Engineering offers valuable background and reference for both the ... Engineering the Stem Cell Niche and the Differentiative Micro- and Macroenvironment: Technologies and Tools for Applying ...
We report a magnetic cell-patterning technique to control arrangements of target cells for the fabrication of three-dimensional ... Steel Plate Human Umbilical Vein Endothelial Cell C2C12 Cell Cell Sheet Cell Patterning These keywords were added by machine ... Wilson, W.,C., Jr., and Boland, T. (2003) Cell and organ printing 1: protein and cell printers. Anat. Rec. A Discov. Mol. Cell ... was formed on a monolayer of cells or a magnetic tissue-engineered cell sheet constructed by accumulating MCL-labeled cells ...
Laboratory for Cell .... Research Lab Laboratory for Cell & Tissue Engineering The Laboratory for Cell & Tissue Engineering ... The Laboratory for Cell & Tissue Engineering facilitates research on the culturing and engineering of the patients own - or ... The Laboratory for Cell & Tissue Engineering is an ultramodern laboratory. The research that takes places here extends across ... Facilities include a fully equipped cell culture room ideal for elaborate experimental tissue engineering. Tissues are tested ...
Synthetic biologists engineer living cells to control how they behave by converting their genes into programmable circuits. A ... which will be useful for developing new methods for tissue engineering, stem cell research and diagnostic applications, just to ... How to Hack a Cell. Posted 3 years ago on Monday, April 3rd, 2017. in NEWS ... Mammalian cells are especially tricky to work with because they are a much more variable environment and express highly complex ...
... including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. ... Cell Engineering and Regeneration. Editors: Gimble, J.M., Marolt, D., Oreffo, R., Redl, H., Wolbank, S. (Eds.) ... as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and ... new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules. ...
... including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. ... This reference work presents the origins of cells for tissue engineering and regeneration, ... including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. ... Cell Engineering and Regeneration. Editors: Gimble, J.M., Marolt Presen, D., Oreffo, R., Wolbank, S., Redl, H. (Eds.) ...
... * Content type: Research. Improved expansion of equine cord blood derived ... Equine mesenchymal stromal cells (MSCs) are increasingly investigated for their clinical therapeutic utility. Such cell-based ... Human pluripotent stem cell differentiation to functional pancreatic cells for diabetes therapies: Innovations, challenges and ... Comprised of parenchymal cells, stromal cells, structural extracellular matrix proteins, and sign... ...
The ambitions of startups in the cell therapy space illustrates just how incredibly audacious - and routinely audacious -- ... We can check the engineered cells and then do single cell cloning to expand a clone that has just the precise engineering we ... the engineered T-cell is called a "CAR-T") is designed to sit on the surface of T cells, recognize a unique target on a tumor ... into the engineering of other types of immune effector cells, including NK cells and macrophages, for the treatment of cancer. ...
Finding factors important for differentiation of antibody-secreting cells will help us engineer a B cell therapy for protein ... Engineering B Cells to Produce Therapeutic Proteins Historically, gene delivery to B cells has been challenging. We recently ... identifying optimal conditions for differentiation of engineered human B cells into long-lived antibody-secreting cells, (2) ... B Cell-Based Protein Delivery Could be a Lifelong Cure Antibody-secreting B cells exhibit two features that we think can be ...
Recently, stem/progenitor cells have been identified in TMJ disc and condyle, with potential origin from neural crest cells in ... Stem Cell Biology and Engineering toward Clinical Translation" will provide a rare forum for multidisciplinary discussion of ... Putative TMJ stem/progenitor cells are subjected to local, hormonal and other systemic factors in homeostasis in multiple ... the biology, engineering and clinical translation of fundamental discoveries towards novel clinical therapy. The symposium is ...
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... fundamental notions of virology and animal cell cultivation, this practical reference examines the development of insect cell ... Resolving on-the-job problems such as sparging cell damage and reduced infectivity cells, Insect Cell Culture Engineering: ... Insect Cell Culture Engineering is designed as a reference for biochemical and bioprocess engineers, bioprocess technologists, ... foreign gene expression in insect cells, Donald L. Jarvis; the future of insect cell culture engineering, Spiros N. Agathos. ...
Limitations in Single-Cell Analysis Must Be Addressed with Innovation. Cannabinoids Liquid Gold: Engineers Strike Oil Making ... Cell Signaling Genotoxic Food Sets Off Immune Alarm That Speeds DNA Damage Response in Gut. ...
... and the Society of Biological Engineering (SBE), this meeting brings together engineers, biologists, and clinicians who are ... working on cellular therapies in order to accelerate progress towards designing the stem cell and its environment. ... Presented by the International Society for Stem Cell Research (ISSCR) ... Presented by the Society of Biological Engineering (SBE) and the International Society for Stem Cell Research (ISSCR), this ...
Scientists from Caltech have shown that putting an RNA-based toggle mechanism into both live mice and human T cells allows them ... to turn cell growth on and off with a specific drug. The researchers ultimately hope to implement the technology in T… ... Engineering a molecular control switch into immune cells could improve their therapeutic potential. ... Engineering Better Immune Cells. Scientists use synthetic biology to create drug-controlled T cells. ...
These data show that QNR/D and QNR/K2 cell lines represent distinct neural cell types, suggesting that migrating neural cells ... a putative Müller cell into chicken embryo eyes. Implanted QNR/D cells migrate only to the retinal ganglion and amacrine cell ... Retinal engineering: engrafted neural cell lines locate in appropriate layers Message Subject (Your Name) has sent you a ... Retinal engineering: engrafted neural cell lines locate in appropriate layers. D Trisler, J Rutin, and B Pessac ...
Nanomaterial Cell Interactions in Tissue Engineering. Engineering Cell Surface Interface in Tissue Engineering and Cell-Based ... Cell-Scaffold Interfaces in Skin Tissue Engineering. Cell and Materials Interface in Cryobiology and Cryoprotection. ... Cell and Material Interface Advances in Tissue Engineering, Biosensor, Implant, and Imaging Technologies By Nihal Engin Vrana. ... Cell and Material Interface: Advances in Tissue Engineering, Biosensor, Implant, and Imaging Technologies. ISBN , Quantity: ...
The Cell Therapy and Cell Engineering Facility Core develops, validates, and implements procedures critical to gene-transfer- ... Cell Therapy and Cell Engineering Facility More About Cell Therapy and Cell Engineering Facility ... Genetic engineering and ex vivo transduction of patient cells (hematopoietic stem cells, dendritic cells, and lymphocytes). ... The Cell Therapy and Cell Engineering Facility develops, validates, and implements procedures critical to gene transfer-related ...
... the gold-standard technique for phenotypic cell sorting-while maintaining high levels of cell viability. We identified ... which increases operational times and costs and limits cell viability. Here, we introduce immunomagnetic cell sorting ... Immunomagnetic cell sorting implemented in a microfluidic chip can perform loss-of-function CRISPR-Cas9-mediated phenotypic ... We used the method to process an entire genome-wide screen containing more than 108 cells in less than 1 h-considerably ...
Both remain disease-free 18 months after treatment and continue to exhibit high levels of the engineered immune cells in their ... The scientists infused the engineered lymphocytes back into their weakened systems and discovered that such cells could persist ... Immune cells such as lymphocytes, also known as T cells and pictured in blue above, recognize health threats via special ... Cancer results from cells gone wild. Proliferating out of control, the cells spawn malignant growths that can travel throughout ...
... using genetically modified embryonic stem cells. The findings, which appear in the journal Stem Cell Reports, are the first ... step to developing a similar protocol using human stem cells that will allow the modeling of thyroid disease to better ... Researchers have discovered a new efficient way to generate thyroid cells, known as thyrocytes, ... Researchers engineer new thyroid cells. Boston University Medical Center. Journal. Stem Cell Reports. Funder. NIH/National ...
The modified cancer cells have demonstrated anti-cancer efficacy in preclinical studies, destroying both primary and metastatic ... Researchers at Brigham and Womens Hospital have engineered cancer cells that track and kill cancer cells. ... Researchers at Brigham and Womens Hospital have engineered cancer cells that track and kill cancer cells. The modified cancer ... With our technique, we show it is possible to reverse-engineer a patients own cancer cells and use them to treat cancer. We ...
Deformed cells express different biosynthetic activity relative to undeformed cells. The unit cell process paradigm combined ... A stress field influences cell function primarily through deformation of the extracellular matrix to which cells are attached. ... with topics in connective tissue mechanics form the basis for discussions of several topics from cell biology, physiology, and ... Deformed cells express different biosynthetic activity relative to undeformed cells. The unit cell process paradigm combined ...
... for Passenger Cars and Electric Vehicles Proton exchange membrane fuel cells (PEMFC) generate efficient ... Fuel Cell Engineering for Heavy-Duty On and Off-Road Vehicles AVL has developed Auxiliary Power Unit (APU) technology based on ... Fuel Cell Solutions for Engineering and Testing With increasingly stringent global emissions legislation and market demands, ... AVL Solid Oxide Fuel Cell Combined Heat and Power AVLs Solid Oxide Fuel Cell Combined Heat and Power (AVL SOFC CHP) stationary ...
... for Passenger Cars and Electric Vehicles Proton exchange membrane fuel cells (PEMFC) generate efficient ... Fuel Cell Solutions for Engineering and Testing With increasingly stringent global emissions legislation and market demands, ... AVL provides high-end customer-specific PEMFC engineering solutions ranging from computational cell/stack/system development ... PEM Fuel Cell Systems for Trucks and Buses Clean power for all applications. ...
Solid Oxide Fuel Cell Center of Economic Excellence. Director: Kenneth Reifsnider, NAE, professor, Mechanical Engineering ... Director: John W. Weidner, professor and chair, Chemical Engineering The mission of the Center for Fuel Cells is to help ... Electrical Engineering*Degree Programs*B.S. - Electrical Engineering*Career Plans*Design ICs for Secure Communications ... The Solid Oxide Fuel Cell Center is a faculty cluster and research facility that is dedicated to the science and engineering ...
Director, Institute for Cell Engineering. Director, Morris K. Udall Parkinsons Disease Research Center. Leonard and Madlyn ... The Neuroregeneration Program at Johns Hopkins Institute for Cell Engineering. Researcher Valina Dawson introduces the ... Scientists use human induced pluripotent stem cells (iPSCs), which can develop into any cell type in the body, to study these ... Some studies are working to crystallize or recreate proteins that may play crucial roles in cell death, develop stem cell-based ...
ICE supports and encourages the application and development of new cell technologies to ultimately develop cell-based therapies ... Scientists in the Stem Cell Biology program have improved the methods for coaxing stem cells into desired cell types for both ... basic cell processes, and how to apply new ideas to further the field of cell engineering. ICE supports and encourages the ... Founded in 2001, the mission of the Institute for Cell Engineering at the Johns Hopkins School of Medicine is to foster a ...
... which has been exploited to engineer whole-cell biosensors (32, 33) and cell-cell communication (5, 10, 34) systems in E. coli ... These features are exploited to engineer cells that form biofilms in response to DNA-damaging agents and cells that activate ... for untreated cells, cells treated with 100 ng/ml MMC for 15 h, and cells exposed to 8 J/m2 UV irradiation before inoculation ... Programmable cells: Interfacing natural and engineered gene networks. Hideki Kobayashi, Mads Kærn, Michihiro Araki, Kristy ...
  • The Laboratory for Cell & Tissue Engineering facilitates culturing of autologous tissues across the full spectrum of the research field. (tue.nl)
  • The Laboratory for Cell & Tissue Engineering facilitates research on the culturing and engineering of the patient's own - or autologous - cell tissues. (tue.nl)
  • The steps involved in culturing and studying these tissues in a laboratory are many and varied: from culturing cells and producing carrier materials, to tissue analysis and testing. (tue.nl)
  • A fully blindable microscopy room is equipped with state-of-the-art confocal and fluorescence microscopes for the detailed analysis of cells and the tissues formed. (tue.nl)
  • In many cases, such as in implants and engineered tissues, the interaction of the cells with the biomaterial is one of the main determinants of the success of the system. (routledge.com)
  • Molecular analysis of gene transfer efficiency and transgene expression in patient cells and tissues (FACS analysis, real-time PCR, immunostaining, etc. (mskcc.org)
  • Metastatic cancer arises when cells from the primary tumour enter either the blood or lymphatic system and then establish themselves in other tissues. (news-medical.net)
  • For example, an appropriate target would be plentiful in tumor cells but absent or nearly so in normal tissues. (eurekalert.org)
  • Receptor-engineered T cells have the potential to cause lethal toxicity from on-target recognition of normal tissues, and there is a paucity of truly tumor-specific antigens shared across tumor types. (nature.com)
  • These animals have unique light manipulating structures that are inside their cells and tissues. (forbes.com)
  • Tunable leucophore cells can change the way the female squids' tissues reflect or transmit light. (forbes.com)
  • A primary goal in tissue engineering is to develop functional tissues by recapitulating salient features of complex biological systems that exhibit a diverse range of physical forces. (nih.gov)
  • B cells can release autoantibodies that damage the body's tissue and provoke T cells into attacks on tissues as well. (sciencemag.org)
  • Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. (elsevier.com)
  • The technology helps nudge medical science closer to one day growing human organ tissues from a person's own cells for regenerative therapy, say study investigators at Cincinnati Children's Hospital Medical Center in the U.S. and Yokohama City University (YCU) in Japan. (cincinnatichildrens.org)
  • And although stem cell-based tissue engineering has tremendous therapeutic potential, its future clinical use still faces the critical challenge of ensuring a blood supply to nourish the transplanted tissues, according to researchers. (cincinnatichildrens.org)
  • Pancreatic islets tissue-engineered in the current generated by the process not only quickly developed a vascular network after transplant into animal models of type 1 diabetes, the tissues also functioned efficiently as part of the endocrine system-secreting hormones like insulin and stabilizing glycemic control in the animals. (cincinnatichildrens.org)
  • Research in the Healy Lab emphasizes the relationship between materials and the cells or tissues they contact. (berkeley.edu)
  • The research program focuses on the design and synthesis of bioinspired materials that actively direct the fate of mammalian cells, and facilitate regeneration of damaged tissues and organs. (berkeley.edu)
  • Due to the increasing needs for organ transplantation and a universal shortage of donated tissues, tissue engineering emerges as a useful approach to engineer functional tissues. (hindawi.com)
  • MIT engineering professor Lorna Gibson found five features that plants 'control and coordinate' when building tissues of various strengths. (icr.org)
  • The creation of engineered replacements for damaged tissues is of critical importance to the future of medicine. (berkeley.edu)
  • Stem cells have tremendous potential as a source for engineered tissues and as cell therapies, and control over stem cell differentiation is a frontier in this area. (berkeley.edu)
  • Due in no small part to advances in microfluidic single cell analysis methods, cell-to-cell variability is an increasingly understood feature of physiological tissues, with cell types from as common as 1 out of every 2 cells to as rare as 1 out of every 100 000 cells having important roles in the biochemical and biological makeup of tissues and organs. (rsc.org)
  • Then we look at how recent single cell analysis strategies have enabled better understanding of heterogeneity within in vitro and in vivo tissues. (rsc.org)
  • Here, we articulate some big questions that need to be addressed before such engineered tissues become mainstream in the clinic. (nih.gov)
  • Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. (dymocks.com.au)
  • Thus, hydrogels are also chosen for the one-step additive manufacturing of 3D constructs containing homogenously distributed cells, which mimic the complex structure of tissues [ 6 , 7 ]. (mdpi.com)
  • As Constant explains: "We sit the cells on the Transwell membrane , which is optimal for differentiation and to generate early standardized in vitro model tissues that we share worldwide with our customers. (corning.com)
  • Stem Cell Engineering offers valuable background and reference for both the public and professionals including industrial staffers, faculty, researchers, engineers, students and scientific journalists. (springer.com)
  • With these circuits, we took a completely different design approach and have created a framework for researchers to target specific cell types and make them perform different types of computations, which will be useful for developing new methods for tissue engineering, stem cell research and diagnostic applications, just to name a few. (bu.edu)
  • BLADE will allow researchers to use different signals, or inputs, in one streamlined device to control the outputs, or behaviors, of the cells they target. (bu.edu)
  • Weinberg noted that the researchers intentionally built complex circuits with complicated functions to illustrate the possibilities using their design, including some that program human cells to add or subtract numbers. (bu.edu)
  • The gist of the approach Anderson described at Century - and of related approaches researchers and startups are exploring globally - is to turn a cell that already is predisposed to assassination and equip it to be a Delta Force commando. (forbes.com)
  • The researchers ultimately hope to implement the technology in T cell therapeutics, which are currently in clinical testing for treating cancer and other diseases. (technologyreview.com)
  • Researchers want to use the switch to improve cell-based cancer therapies. (technologyreview.com)
  • Thanks to advances in genetic engineering and gene therapy, researchers are now modifying the isolated cells to better attack cancer. (technologyreview.com)
  • The researchers injected T cells containing the construct into animals and then fed them theophylline, demonstrating that the modified T cells only prospered when the animals were given the drug. (technologyreview.com)
  • The researchers introduced this genetic information into regular T cells from 17 melanoma patients via retrovirus. (scientificamerican.com)
  • Boston)--Researchers have discovered a new efficient way to generate thyroid cells, known as thyrocytes, using genetically modified embryonic stem cells. (eurekalert.org)
  • Researchers from Boston University School of Medicine (BUSM), engineered mouse embryonic stem cells cultured in the lab to express a genetic switch for a specific gene, Nkx2-1, that is important for thyroid development. (eurekalert.org)
  • The researchers hope this study will lead to the development of therapeutics or stem cell/genetic engineering technologies that will improve the quality of life for the many people afflicted with thyroid and other disorders. (eurekalert.org)
  • Researchers at Brigham and Women's Hospital have engineered cancer cells that track and kill cancer cells. (news-medical.net)
  • Researchers have genetically engineered tumour cells to include a cytotoxic mechanism. (news-medical.net)
  • In the near term, the researchers plan to build a frozen zoo of stem cells that scientists can use to study the animals' genomes, and perhaps to create stem-cell therapies for the animals. (technologyreview.com)
  • Researchers would need to first create sperm or eggs from the stem cells and then use them with sperm or eggs from a living animal to create an embryo. (technologyreview.com)
  • Bringing together researchers who aim to engineer cells to improve human health, the Institute provides a multidisciplinary environment at the Johns Hopkins University School of Medicine that stimulates collaboration in hopes of accelerating progress. (hopkinsmedicine.org)
  • As the virus is capable of evading T-cell attacks, however, some researchers have suggested re-engineering these cells to improve their chances of neutralizing an HIV infection. (courthousenews.com)
  • The researchers found that when they fed mice that had liver tumours, their engineered bacteria travelled directly to the anaerobic regions of the tumours. (newscientist.com)
  • Written by a team of leading experts and well-recognised researchers, this is an essential resource for students and researchers in biomedical engineering. (cambridge.org)
  • While that is far from becoming a reality, a group of researchers was able to design and engineer human cells that are capable of becoming transparent in their laboratory experiments. (forbes.com)
  • In this case, the researchers focused on one type of female squid known as Doryteuthis opalescens that is common in California and also has a unique version of cells called leucophores. (forbes.com)
  • The researchers also used different concentrations of salt or sodium chloride to alter the degree of transparency in the genetically engineered human cells. (forbes.com)
  • Researchers at the Johns Hopkins University are working to engineer single-cell organisms that will seek out and eat bacteria that are deadly to humans. (baltimoresun.com)
  • Researchers tissue-engineered human pancreatic islets in a laboratory that develop a circulatory system, secrete hormones like insulin and successfully treat sudden-onset type 1 diabetes in transplanted mice. (cincinnatichildrens.org)
  • Using either donated organ cells, mouse cells or iPS cells, the researchers combined these with MSNs, HUVECs along with other genetic and biochemical material that cue the formation of pancreatic islets. (cincinnatichildrens.org)
  • After the tissue-engineered islets were transplanted into humanized mouse models of severe type 1 diabetes, they resolved the animals' disease, report researchers. (cincinnatichildrens.org)
  • Researchers deem that hardwoods contain complex tissue because in addition to parenchyma cells they have vessels and fibers. (icr.org)
  • Researchers from UCLA's cancer and stem cell centers have demonstrated for the first time that blood stem cells can be engineered to create cancer-killing T-cells that seek out and attack a human melanoma. (scienceblog.com)
  • Researchers used a T-cell receptor - cloned by other scientists from a cancer patient - that seeks out an antigen expressed by a certain type of melanoma. (scienceblog.com)
  • According to the researchers, the cells can generate 10 times the amount of power per surface area than an existing wearable cell. (thomasnet.com)
  • The funds from the contracts will be used by UNF researchers to continue the development and commercialization of direct methanol fuel cell power sources for two laptops, one to be used by American soldiers and the other by the average consumer. (unf.edu)
  • UNF and University of Florida researchers along with UNF engineering students are working to replace the battery in military laptops with a methanol fuel cell to make our soldiers more efficient and safer in battle. (unf.edu)
  • Researchers filter those cells from a patient's blood, reprogram them to harbour a 'chimeric antigen receptor' that zeroes in on cancer, and grow hundreds of millions of copies. (cbc.ca)
  • The researchers placed different versions of the cell at different points in the stingray, each sensitive to a different wavelength of light. (extremetech.com)
  • Researchers are looking at actin polymerization and calcium uptake in human cells to study mitochondrial division. (the-scientist.com)
  • Now, in the January 2005 issue of Acta Biomaterialia, the researchers report the most complete and quantitative characterization yet of how a healthy human blood cell changes its shape, or deforms, upon being invaded by the malaria-inducing parasite Plasmodium falciparum. (innovations-report.com)
  • In the same article, the researchers show how the deformation of human pancreatic cancer cells in response to certain naturally occurring biomolecules may affect the metastasis of that disease. (innovations-report.com)
  • The forces obtained by the MIT-led researchers are several times larger, and their technique offers considerably greater flexibility to mechanically manipulate cells than other methods. (innovations-report.com)
  • Carmi said this finding demonstrates that the immune system can be utilized to identify and fight all types of cancer.The researchers are testing their configuration of engineered T cells in preclinical mouse models of cancer and in human samples. (israel21c.org)
  • In observing kidney cells from the FAN1 knockout mice, the researchers noticed that their nuclei were abnormally large. (medicalnewstoday.com)
  • The researchers engineered an actuator module with an output that converted an inactive drug into an active form that causes cells to die. (stanford.edu)
  • IGERT trainees will acquire global perspectives through internships and workshops with leading stem cell researchers at over 15 sites in Europe and Asia. (igert.org)
  • The researchers targeted two transmembrane proteins called integrins that influence the behavior of platelets, small blood cells important in clotting. (sciencecodex.com)
  • Going back in time to observe how cells with key gene mutations interact and become invasive would help researchers better understand how the cancer starts and identify it sooner. (purdue.edu)
  • Invasive cancer sprouts from an artificial pancreatic duct engineered by Purdue University researchers. (purdue.edu)
  • A pancreatic cancer "time machine" engineered by Purdue University researchers has revealed that the disease is even more unpredictable than previously thought: Cancer cells promote each other's invasiveness when they grow together. (purdue.edu)
  • Since the paper's publication, the researchers also have found drug resistance in cancer cell types originating from two drug-sensitive ones. (purdue.edu)
  • By injecting cancer cell lines into microfluidic channels within the artificial duct, the researchers can use the system as a model for observing how pancreatic cancer behaves over time. (purdue.edu)
  • The tumor model speeds up time because researchers can load in cell lines from an animal model or patient without waiting for gene mutation to happen first. (purdue.edu)
  • The researchers saw that after two different cancer cell types merged into the pancreatic tumor model device, these cells became more invasive and sprouted from the duct to form tumors. (purdue.edu)
  • are working on cellular therapies in order to accelerate progress towards designing the stem cell and its environment. (aiche.org)
  • This system gives us the ability to control the fate and function of cell-based therapies," says Michael Jensen , director of the pediatric cancer program at the City of Hope, a research and treatment center in Duarte, CA, and an author of the paper. (technologyreview.com)
  • For example, a number of therapies now being tested in patients use T cells engineered to carry a molecule that allows them to selectively bind to cancer cells. (technologyreview.com)
  • It does address one of the problems with T cell therapies, which is survival and persistence of these cells," says Darrel Irvine , a bioengineer at MIT who was not involved in the research. (technologyreview.com)
  • The findings, which appear in the journal Stem Cell Reports , are the first step to developing a similar protocol using human stem cells that will allow the modeling of thyroid disease to better understand its causes and the development of therapies. (eurekalert.org)
  • Cell-based therapies hold tremendous promise for delivering therapeutic agents to tumours and may provide treatment options where standard therapy has failed. (news-medical.net)
  • Some studies are working to crystallize or recreate proteins that may play crucial roles in cell death, develop stem cell-based therapies for neurologic disease and understand how cells communicate in Parkinson's and Alzheimer's diseases. (hopkinsmedicine.org)
  • The Michael G. Harris Cell Therapy and Cell Engineering Facility (CTCEF) is a state-of-the-art resource that provides support to Memorial Sloan Kettering Cancer Center investigators who are conducting phase I and phase II clinical trials that require cell and/or vector manufacture in the realms of adoptive immunotherapies, vaccines, and stem cell-based therapies. (mskcc.org)
  • The definitive rapid-publication journal covering all aspects of gene therapy through original investigations into the transfer and expression of genes in mammals, with in-depth coverage of DNA, RNA, and cell therapies. (liebertpub.com)
  • Here we offer our perspective on how expanding the use of genetically redirected T cells to treat the majority of patients with solid cancers will require major technical, manufacturing and regulatory innovations centered around the development of autologous gene therapies targeting private somatic mutations. (nature.com)
  • Future developments in cancer therapy are likely to focus on methods to target these therapies to diseased but not normal cells. (booktopia.com.au)
  • There are currently no treatments, and salivary glands have little capacity to renew themselves, highlighting a need for cell-based therapies that can grow new tissue and restore gland function. (medicalnewstoday.com)
  • As humans lack the ability to regenerate myocardial tissue lost afte a heart attcak, there has been great focus on cardiovascualr regenerative therapies with the use of human embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC). (ca.gov)
  • We hope to by the end of this porject determine the ideal conditions for derivation of these CPCs from iPSCs and the environmental cues needed for culturing these cells to allow for maximal yield for potential use in clinical regenerative therapies in the future. (ca.gov)
  • Cell therapies which harness and enhance a patient's own biology are helping to address areas of unmet medical need. (wired.co.uk)
  • But we still have a lot to discover: about cell therapy, about the diseases, about how to make sure patients are receiving therapies in the best way possible. (wired.co.uk)
  • T-cell therapies are not just for cancer. (the-scientist.com)
  • Based on this discovery we were able to engineer novel T cells with enhanced tumor-killing activity and higher specificity, compared with other T cell-based therapies for cancer. (israel21c.org)
  • As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration. (dymocks.com.au)
  • In situ tissue regeneration approach aims to exploit the body's own biological resources and reparative capability and recruit host cells by utilizing cell-instructive biomaterials. (biomedcentral.com)
  • Polysaccharide-Based Biomaterials for Cell-Material Interface. (routledge.com)
  • We are a 'biomaterials' and 'stem-cell based tissue engineering' laboratory and use biomaterials to culture, proliferate and induce differentiation in stem cells to understand how the ECM-stem cell interaction modulates cell fate and turnover. (utep.edu)
  • This article first describes how the mechanical properties of the environment are important determinants of developmental processes, and then further details how biomaterials can be designed to precisely control the mechanics of cell-matrix interactions in order to study and define their reprogramming, self-renewal, differentiation, and morphogenesis. (nih.gov)
  • Engineered biomaterials can be used to model diverse mechanical properties of ECM. (nih.gov)
  • In cooperation with various institutes for material research we are investigating how biomaterials, surface topography, and elasticity impact on growth and differentiation of stem cells. (ukaachen.de)
  • Here, we review the recent advancement in developing fibrin-based biomaterials for the development of injectable tissue engineering scaffold and cell carriers. (hindawi.com)
  • technological challenges, stem cell growth and differentiation, therapeutic applications, bioreactors and bioprocesses, high throughput and microfluidic screening platforms, stem cell identification and sorting, intercellular signaling and engineered niches, novel approaches for embryonic and adult stem cell growth and differentiation, stem cells and drug discovery, screening platforms. (springer.com)
  • The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules. (springer.com)
  • Dr. Gimble is Co-founder and Chief Scientific Officer of LaCell LLC and Obatala Sciences Inc. For over 30 years, Dr. Gimble's laboratory has focused on stromal/stem cells isolated from bone marrow and adipose tissue as a model system for differentiation, hematopoiesis, metabolism, and regenerative medicine. (springer.com)
  • Recent advances in the expansion and directed pancreatogenic differentiation of human pluripotent stem cells (hPSCs) have intensified efforts to generate functional pancreatic islet cells, especially insulin-s. (biomedcentral.com)
  • We study the proteins and genes responsible for differentiation of and/or long-lived survival of antibody-secreting cells. (seattlechildrens.org)
  • Our lab is currently focused on (1) identifying optimal conditions for differentiation of engineered human B cells into long-lived antibody-secreting cells, (2) assessing the impact of autophagy on plasma cell survival, and (3) determining the effect that a host immune system will have on engrafted engineered B cells. (seattlechildrens.org)
  • The suppression of apoptosis by the IGF system is critical for normal cell development, proliferation, differentiation and motility. (booktopia.com.au)
  • In addition to angiogenesis, 'vasculogenesis' denotes the formation of blood vessels through the de novo differentiation of stem cells into endothelial cells such as during embryonic development [ 2 ]. (mdpi.com)
  • We characterize how epigenetic changes are acquired during differentiation and how cell fate is regulated by external stimuli. (ukaachen.de)
  • Cellular differentiation is governed by epigenetic changes - and hence the epigenetic makeup is ideally suited to characterize cells. (ukaachen.de)
  • J. Lock, T. Y. Nguyen, and H. Liu, "Nanophase hydroxyapatite and poly(lactide- co -glycolide) composites promote human mesenchymal stem cell adhesion and osteogenic differentiation in vitro," Journal of Materials Science: Materials in Medicine , vol. 23, no. 10, pp. 2543-2552, 2012. (hindawi.com)
  • These materials will be presented to cells in 2D and 3D to determine their impact upon CPC maintenance, proliferation and differentiation to the ventricular cardiac myocyte lineage. (ca.gov)
  • Under terms of the formal agreement, the agencies agreed upon a joint regulatory framework wherein FDA oversees cell collection, cell banks, and cell growth and differentiation. (foodengineeringmag.com)
  • Rat neural stem cells (NSCs) were cultured in monolayer or in porous collagen scaffolds and exposed to neurogenic or non-neurogenic medium to determine the effects on neural differentiation and neurite growth. (mit.edu)
  • Constant and his team harness the latest innovations in cell culture technology and tissue engineering to generate these advanced cellular models and use permeable supports from Corning Life Sciences to achieve the cellular differentiation that they require. (corning.com)
  • In the world of early-stage life science, where I sit, it is positively staggering to contemplate what passes for commonplace in today's world of engineered biology. (forbes.com)
  • On March 23, during the 41st Annual Meeting & Exhibition of the American Association for Dental Research (AADR), held in conjunction with the 36th Annual Meeting of the Canadian Association for Dental Research, a symposium titled "TMJ: Stem Cell Biology and Engineering toward Clinical Translation" will provide a rare forum for multidisciplinary discussion of the biology, engineering and clinical translation of fundamental discoveries towards novel clinical therapy. (redorbit.com)
  • Scientists use synthetic biology to create drug-controlled T cells. (technologyreview.com)
  • In 2007, Smolke developed an RNA-based "on-off switch" using the principles of synthetic biology, an offshoot of genetic engineering in which scientists create functioning biological "parts" from molecular components. (technologyreview.com)
  • It's a lot of sophisticated molecular biology," Rosenberg notes, "and most of our work is going into designing retroviruses, putting genes into cells efficiently and getting them expressed. (scientificamerican.com)
  • The unit cell process paradigm combined with topics in connective tissue mechanics form the basis for discussions of several topics from cell biology, physiology, and medicine. (mit.edu)
  • The engineering of gene regulatory networks is a cornerstone of synthetic biology ( 1 , 2 ) and has been instrumental in elucidating basic principles that govern the dynamics of small gene networks ( 3 - 14 ) and the origins and consequences of stochasticity in gene expression ( 13 - 18 ). (pnas.org)
  • Their work combines the fields of biology and engineering in an emerging discipline known as synthetic biology. (baltimoresun.com)
  • We're using this as a test bed for determining do we understand how cells work to the point where we can engineer them to perform certain tasks," said Douglas N. Robinson, a professor of cell biology and a member of the Hopkins team. (baltimoresun.com)
  • Professor Desai's research spans multiple disciplines including materials engineering, cell biology, tissue engineering, and drug delivery. (berkeley.edu)
  • Candidate must possess strong molecular biology skills and extensive mammalian cell experience. (aftercollege.com)
  • W. Grayson, S. Bhumiratana, C. Cannizzaro, and G. Vunjak-Novakovic, "Bioreactor cultivation of functional bone grafts," in Mesenchymal Stem Cell Assays and Applications , vol. 698 of Methods in Molecular Biology , pp. 231-241, Humana Press, 2011. (hindawi.com)
  • While this project uses synthetic cells as a precedent, Choi is quick to point out that the potential uses are not restricted to biology. (purdue.edu)
  • Using viral and nonviral constructs, synthetic biology tools, mouse models, and patient samples from CAR -T cell clinical trials, the laboratory has identified key genes of T cell resistance and different components of the tumor microenvironment that induce CAR -T cell suppression. (mayo.edu)
  • The EPSRC Centre for Doctoral Training in BioDesign Engineering aims to train the next generation of leaders at the interface of biology, engineering and data science. (findaphd.com)
  • Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. (dymocks.com.au)
  • Synthetic biology is generally understood to be a graft of engineering and biology, and this has led to some confusing and unhelpful metaphors. (genscript.com)
  • In this webinar, Dr. Richardson will introduce you to the interdisciplinary world of synthetic biology, busting some of the popular myths about this field-DNA is not a programming language, and cells are not compilers or circuit boards! (genscript.com)
  • Cell biology (also cellular biology or cytology) is a branch of biology studying the structure and function of the cell, also known as the basic unit of life. (wikipedia.org)
  • Cell biology encompasses both prokaryotic and eukaryotic cells and can be divided into many sub-topics which may include the study of cell metabolism, cell communication, cell cycle, biochemistry, and cell composition. (wikipedia.org)
  • Modern-day cell biology research looks at different ways to culture and manipulate cells outside of a living body to further research in human anatomy and physiology, and to derive medications. (wikipedia.org)
  • Many techniques commonly used to study cell biology are listed below: Cell culture: Utilizes rapidly growing cells on media which allows for a large amount of a specific cell type and an efficient way to study cells. (wikipedia.org)
  • This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. (springer.com)
  • Human induced pluripotent stem cells (hiPSCs) can form any tissue found in the body, making them attractive for regenerative medicine applications. (biomedcentral.com)
  • Scientists use human induced pluripotent stem cells (iPSCs), which can develop into any cell type in the body, to study these disorders. (hopkinsmedicine.org)
  • Finally, a perspective is presented on how insights from the mechanics of cell-matrix interactions can be leveraged to control pluripotent stem cells for tissue engineering applications. (nih.gov)
  • Scientists tested their processing system with donated human organ cells (pancreas, heart, brain, etc.), with mouse organ cells and with induced pluripotent stem cells (iPS). (cincinnatichildrens.org)
  • Our research focusses on molecular mechanisms that regulate human stem cells, particularly hematopoietic stem cells, mesenchymal stem cells, and induced pluripotent stem cells. (ukaachen.de)
  • Alternatively these cells can be derived from induced pluripotent stem cells, which may result in more standardized cell preparations. (ukaachen.de)
  • Furthermore, we differentiate induced pluripotent stem cells towards hematopoietic lineages that may be used for disease modeling and address the relevance of specific genes and splice variants (e.g. by CRISPR-Cas9n technology). (ukaachen.de)
  • Using these methods, we report nuclease-mediated indel rates of up to 94% in Jurkat T cells and 87% in induced pluripotent stem cells (iPSC) for a single target. (nih.gov)
  • The combined power of human pluripotent stem cells and tissue engineering promises to revolutionize medicine by building tissue patches and artificial replacement organs for patients battling diverse diseases. (nih.gov)
  • Although different synthetic materials have been used to fabricate tissue engineering scaffolds, they have many limitations such as the biocompatibility concerns, the inability to support cell attachment, and undesirable degradation rate. (hindawi.com)
  • After several weeks in culture, the cells produced a 3D matrix covering the silk scaffolds. (medicalnewstoday.com)
  • The ability to design biocompatible materials and to understand cellular and physiological mechanics makes possible the construction of engineered scaffolds for cells. (berkeley.edu)
  • Laminin coated scaffolds promoted the attachment of NSCs to the scaffold struts and resulted in a more even distribution of nestin and [beta]III-tubulin positive cells throughout the scaffold. (mit.edu)
  • PCL-PEG blends were evaluated concerning plotting properties to fabricate 3D scaffolds, namely miscibility, wetting behaviour and in terms of cell response. (mdpi.com)
  • Blends showed improved hydrophilicity and cell response with PEG blending increasing the degradation and decreasing the mechanical properties of the scaffolds. (mdpi.com)
  • Increased degradation of the thermoplastic support structure and proliferation of the cells not only in the hydrogel, but also on the thermoplastic phase, indicates the potential of this novel material combination for biofabricating 3D tissue engineering scaffolds. (mdpi.com)
  • Irradiated GM-CSF-secreting cancer cell vaccines induce antitumor immune responses by recruiting antigen-presenting cells, such as DCs, to immunization sites. (aacrjournals.org)
  • as well as the engineering of artificial antigen presenting cells. (mskcc.org)
  • The novel approach to therapy involves extracting T cells from the patient, subjecting the cells to chimeric antigen receptor (CAR) cell engineering, and then infusing the engineered T cells back into the patient. (medscape.com)
  • when the cells are inserted back into the patient's body, they home in on this antigen, latch on and destroy the leukemic cell. (medscape.com)
  • That strategy relied on a chimeric antigen receptor (CAR), a synthetic protein that can be added to T cells to boost their ability to fight a specific foe. (courthousenews.com)
  • Preliminary data from a clinical trial for patients with acute myeloid leukemia (AML) in which T cells are being engineered with a receptor selected for its ability to target the WT1 antigen. (eurekalert.org)
  • The nice thing about this approach is a few engineered stem cells can turn into an army of T-cells that will respond to the presence of this melanoma antigen," Vatakis said. (scienceblog.com)
  • These cells can exist in the periphery of the blood, and if they detect the melanoma antigen, they can replicate to fight the cancer. (scienceblog.com)
  • The mice were then implanted with two types of melanoma tumors, one that expressed the antigen complex that attracts the engineered T-cells and one that did not. (scienceblog.com)
  • The engineered cells specifically went after the antigen-expressing melanoma, leaving the control tumor alone, Zack said. (scienceblog.com)
  • For decades, scientists have been working to reengineer T-cells, adding chimeric antigen receptors (or CARs) to attack cancerous cells. (wired.co.uk)
  • A new study led by Dr. Yaron Carmi of Tel Aviv University's Sackler Faculty of Medicine finds that a form of immunotherapy - chimeric antigen receptors (CAR) T-cell therapy, used to treat the blood cancer leukemia- may work against other kinds of cancer as well. (israel21c.org)
  • CAR T-cell therapy uses T cells collected from the patient and modified in the lab to attach to a specific antigen on the tumor cells and kill them. (israel21c.org)
  • We will test and identify an optimized chimeric antigen receptor (CAR) to modify blood forming stem cells to form cells that will target HIV infection using humanized mice. (ca.gov)
  • Steven Rosenberg of the National Cancer Institute and his colleagues first cloned the genes governing the cancer-recognizing receptor in immune cells from a patient who had successfully beaten back melanoma. (scientificamerican.com)
  • Adoptive transfer of receptor-engineered T cells has produced impressive results in treating patients with B cell leukemias and lymphomas. (nature.com)
  • They then genetically engineered the human blood stem-cells by importing genes for the T-cell receptor into the stem cell nucleus using a viral vehicle. (scienceblog.com)
  • The development of CRS is related to rapid expansion of T cells and subsequent cytokine release and is typically treated with IL-6 receptor blockade and steroids. (mayo.edu)
  • The T-cells are then separated out, and a new gene is introduced - a molecule receptor to recognise target cancer cells. (wired.co.uk)
  • A single receptor on natural killer cells recognizes an amino acid sequence conserved across Zika, dengue, and related pathogens. (the-scientist.com)
  • Our lab discovered a distinct subset of helper T cells, also known as CD4+ T cells, that express the high-affinity receptor for IgG [an antibody] and efficiently kill tumor cells coated with these antibodies," explained Carmi. (israel21c.org)
  • The cell-surface receptor, SIRP-alpha, initiates the innate immune response in hosts. (the-scientist.com)
  • A new study published by Assistant Professor Wilson Wong (BME), and co-authored by Research Assistant Professor Swapnil Bhatia (ECE), in Nature Biotechnology outlines a new simplified platform to target and program mammalian cells as genetic circuits, even complex ones, more quickly and efficiently. (bu.edu)
  • Graduate student Benjamin Weinberg worked with Assistant Professor Wilson Wong (BME) to build a new platform to make it easier to target and program mammalian cells as genetic circuits. (bu.edu)
  • Mammalian cells are especially tricky to work with because they are a much more variable environment and express highly complex behaviors, rendering the electronics approach to circuit design time consuming at best and unreliable at worst. (bu.edu)
  • Essentially, with BLADE, you can implement any combination of computations you want in mammalian cells. (bu.edu)
  • In the Cell Line Engineering Group 1, our goal is to improve the efficacy and safety of recombinant therapeutics by manipulating the glycosylation pathways in mammalian cells. (a-star.edu.sg)
  • Our group also directs efforts towards investigating the molecular mechanisms that underlies the function, regulation and localization of glycosyltransferases and nucleotide sugar transporters in mammalian cells. (a-star.edu.sg)
  • This approach can be generally useful for the analysis of normal and pathologic networks in mammalian cells. (psu.edu)
  • Here we describe methods for rapid synthesis of gRNA and for delivery of Cas9 protein/gRNA ribonucleoprotein complexes (Cas9 RNPs) into a variety of mammalian cells through liposome-mediated transfection or electroporation. (nih.gov)
  • A pseudoviral-packaged lentiviral sgRNA and Cas9 construct can be highly efficiently transduced and integrated into virtually any mammalian cells. (webnewswire.com)
  • One of the major factors attributing the growth are scalability of CRISPR/Cas9 in modifying the multiple sites within the mammalian genome providing a robust, high-throughput approach for gene editing in mammalian cells. (webnewswire.com)
  • Figure 2: Safety and tissue-selectivity mechanisms that may be inserted into gene-engineered T cells. (nature.com)
  • Molecules and Cells. (wikipedia.org)
  • However, the treatment is tough on patients-it requires chemotherapy and radiation to wipe out the natural T cells, enhancing the interaction between immune molecules and the modified cells. (technologyreview.com)
  • T cell receptors are molecules on the surfaces of T cells that are responsible for recognizing and binding to antigens. (eurekalert.org)
  • Some examples of nanomachines found in nature are biological cells, molecular motors that produce mechanical work (e.g. myosin), and biochemical molecules, complexes, and circuits that are capable of processing chemical signals. (igi-global.com)
  • Examples of artificially synthesized nanomachines include synthetic molecules, genetically engineered cells, artificial cells, and bio-silicon hybrid devices that are programmed to produce intended biochemical reactions. (igi-global.com)
  • Scientists claim to have discovered DNA-like molecules inside specialized cells taken from a type of duckbill dinosaur. (icr.org)
  • These include secondary modification of CAR -T cells and combination strategies with monoclonal antibodies, small molecules, peptides and other immunotherapeutic strategies. (mayo.edu)
  • Assistant Professor of Bioengineering Christina Smolke has engineered biological molecules that regulate a cell's behavior by adjusting their own forms and functions in response to the internal conditions of the cell. (stanford.edu)
  • Proton exchange membrane fuel cells (PEMFC) generate efficient and emission-free power for electric vehicles. (avl.com)
  • Her team aims to generate stem cells for at least 10 other species, including snow leopards and some species of elephants. (technologyreview.com)
  • they could both differentiate into various cell types and generate more of themselves. (technologyreview.com)
  • Instead of storing electrical energy received from an external source, fuel cells generate their own. (theengineer.co.uk)
  • Quantum Dot (QD) superlattice incorporated in the active region of a p - i - n single-junction solar cell has attracted significant interest as a potential means of utilizing the sub-bandgap infra-red photons to generate additional photocurrents, through absorption via superlattice miniband states, beyond that corresponding to the valence-to-conduction band transitions (Luque, 1997). (igi-global.com)
  • Cellular engineering focuses on cell-level phenomena, while tissue engineering and regenerative medicine seek to generate or stimulate new tissue for disease treatment. (berkeley.edu)
  • Specifically, we aim to generate host cells for the production of therapeutic biologics with enhanced efficacy. (a-star.edu.sg)
  • Now, there is the promise of relief, as a new study shows how - with the help of silk fibers - it may be possible to generate new salivary glands out of stem cells. (medicalnewstoday.com)
  • We knew from previous studies that we could generate engineered T-cells. (scienceblog.com)
  • The cells are made with an enzyme that oxidizes the lactic acid in your sweat to generate current. (thomasnet.com)
  • Hi, I belong to a company that produces bioethanol, and we are currently looking for fuel cells that can generate energy based on bioethanol. (eng-tips.com)
  • Alternative splicing is an everyday process for many cells and is a powerful way to generate a diverse array of proteins inside a cell. (stanford.edu)
  • Scientists from Caltech have shown that putting an RNA-based toggle mechanism into both live mice and human T cells allows them to turn cell growth on and off with a specific drug. (technologyreview.com)
  • Scientists have long hoped to harness the power of the immune system to kill cancer cells, which can evade immune detection. (technologyreview.com)
  • Now scientists have transformed immune cells into cancer fighters outside the body--and prompted complete remission in two subjects when those cells were reintroduced. (scientificamerican.com)
  • The scientists infused the engineered lymphocytes back into their weakened systems and discovered that such cells could persist, making up between 9 percent and 56 percent of the T cell population one month after treatment in 15 of the 17 patients. (scientificamerican.com)
  • Scientists have created stem cells from frozen skin samples of the endangered northern white rhinoceros. (technologyreview.com)
  • Fertility scientists are avidly searching for ways to develop sperm and eggs from stem cells in order to treat human infertility, and Loring hopes those technologies could be applied to these animals. (technologyreview.com)
  • The scientists found that T cells expressing the new CAR were over 50 times more effective at preventing viral spread than those with the original CAR, based on experiments on human cells in the lab. (courthousenews.com)
  • Our data shows for the first time that engineered T cells can significantly control viral rebound in the absence of ART in vivo," the scientists write. (courthousenews.com)
  • If the scientists are successful at making the cells perform tasks, it also could have important implications for research into cancer and other diseases. (baltimoresun.com)
  • Now, scientists have found that a novel treatment that wipes out the immune system's B cells cures mice of the condition. (sciencemag.org)
  • Since CAR-T therapy emerged, scientists who study autoimmune diseases have eyed it with interest because B cells are involved in many of these diseases. (sciencemag.org)
  • Then, the scientists infused the genetically altered T cells into 41 animals. (sciencemag.org)
  • Scientists reporting research data in Cell Reports say their goal is to one day translate the bioengineering process to human patients with diabetes. (cincinnatichildrens.org)
  • In a study published by Cell Reports , the scientists use a new bioengineering process they developed called a self-condensation cell culture. (cincinnatichildrens.org)
  • IGERT is an NSF-wide program intended to meet the challenges of educating U.S. Ph.D. scientists and engineers with the interdisciplinary background, deep knowledge in a chosen discipline, and the technical, professional, and personal skills needed for the career demands of the future. (igert.org)
  • Scientists have struggled to decide whether viruses are alive or not and whether they are in agreement with the cell theory. (wikipedia.org)
  • Due to advancements in microscopy, techniques and technology have allowed for scientists to hold a better understanding of the structure and function of cells. (wikipedia.org)
  • Synthetic biologists engineer living cells to control how they behave by converting their genes into programmable circuits. (bu.edu)
  • The problem synthetic biologists are trying to solve is how we ask cells to make decisions and try to design a strategy to make the decision we want it to," said Wong. (bu.edu)
  • Next-generation strategies, which include designing better, more targeted synthetic T cell receptors and manipulating other factors, such as elements of the tumor environment, to improve antitumor activity. (eurekalert.org)
  • Fibrin gel, a biopolymeric material, provides numerous advantages over synthetic materials in functioning as a tissue engineering scaffold and a cell carrier. (hindawi.com)
  • Jong Hyun Choi, associate professor of mechanical engineering, has created synthetic cells that mimic these two behaviors: sensing a chemical, and then moving to follow it. (purdue.edu)
  • Choi's team has constructed a synthetic replica of a biological cell which can be "programmed" to follow the chemical trail left behind by another cell. (purdue.edu)
  • Constructing synthetic cell-mimicking systems, such as a dynamic protocell, likewise requires molecular mechanisms that respond to environmental stimuli and execute programmed motility behaviors. (purdue.edu)
  • It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. (springer.com)
  • The book provides a solid starting point for elucidating and exploiting the different aspects of cellular interactions with materials for biomedical engineering. (routledge.com)
  • Novel cellular behaviors and characteristics can be obtained by coupling engineered gene networks to the cell's natural regulatory circuitry through appropriately designed input and output interfaces. (pnas.org)
  • Although the engineering of cellular behavior is not novel, most existing programmed cells are designed for specific purposes, such as whole-cell biosensing ( 35 - 39 ), programmed self-destruction ( 40 - 43 ), and protein synthesis controlled by excess glucolytic flux ( 44 ) or cell density ( 33 , 45 ). (pnas.org)
  • Two areas in which the department has established special leadership are cellular mechanobiology, which focuses on understanding the interaction and conversion between force-based and biochemical information in living systems, and stem cell engineering, which includes platforms to expand, implant, and mobilize stem cells for tissue repair and replacement. (berkeley.edu)
  • She/he will also have an opportunity to contribute to internal technology platforms with creative protein engineering for novel functions, expression technology improvements, or innovative cellular assay design. (aftercollege.com)
  • Gibson wrote, 'These large ranges arise from the composition of the cell wall, the number of layers in the cell wall and the volume fraction and arrangement of cellulose fibres in those layers, as well as the cellular structure of the plant tissue. (icr.org)
  • Using a new method called ARACNe (algorithm for the reconstruction of accurate cellular networks), we report the reconstruction of regulatory networks from expression profiles of human B cells. (psu.edu)
  • Although scale-free networks may represent a common blueprint for all cellular constituents, evidence of scale-free topology in higher-order eukaryotic cells is currently limited to coexpression networks 3,4 , which tend to identify entire subpathways rather than individual interactions. (psu.edu)
  • This challenge, called network reverse engineering or deconvolution, has led to an entirely new class of methods aimed at producing high-fidelity representations of cellular networks as graphs, where nodes represent genes and edges between them represent interactions, either between the encoded proteins or between the encoded proteins and the genes (we use 'genetic interaction' to refer to both types of mechanisms). (psu.edu)
  • Our study is based on ARACNe (algorithm for the reconstruction of accurate cellular networks), a new approach for the reverse engineering of cellular networks from microarray expression profiles. (psu.edu)
  • Expanding engineered cellular therapy. (mayo.edu)
  • Like jewels in a vault, our precious genetic material is stored in the nucleus of a cell--sequestered away from potentially damaging cellular components and toxins so that no harm can come to it. (medicalnewstoday.com)
  • Learn how a company in Switzerland is harnessing the latest cell culture technology to build even more predictive 3D cellular models for respiratory disease research. (corning.com)
  • Add to this scenario government policy on the reduction, refinement, and replacement of animals in research - the so-called '3Rs' agenda - and you have the perfect drivers for the latest human cellular models derived through tissue engineering techniques to be as close to life-like as possible. (corning.com)
  • Wong's approach uses DNA recombinases, enzymes that cut and paste pieces of DNA sequences, allowing for more targeted manipulation of cells and their behavior. (bu.edu)
  • The behavior of the programmed cell is then determined by the dynamical and logical properties of the regulatory module and by the signaling pathways that are used as input and output interfaces. (pnas.org)
  • Cell and tissue engineering centers on the application of physical and engineering principles to understand and control cell and tissue behavior. (berkeley.edu)
  • More importantly, they are aiming to progress beyond just two species of cells ("lead" and "follow") to more complex swarming behavior with many different types of cells. (purdue.edu)
  • These tissue-engineered constructs are designed to promote desirable cell behavior, leading to enhanced effectiveness inside the body and, potentially, remodeling of the implant into healthy tissue without rejection issues. (berkeley.edu)
  • The curvature of the pancreatic duct affects the behavior of cells. (purdue.edu)
  • We could culture these cancer cells on a petri dish, but because the dish is flat, we wouldn't see the same behavior," said Han, who is the program leader of the Purdue University Center for Cancer Research and has a courtesy appointment in biomedical engineering . (purdue.edu)
  • We report a magnetic cell-patterning technique to control arrangements of target cells for the fabrication of three-dimensional (3D) tissue constructs. (springer.com)
  • We harvested T cells from humans, and when we put the constructs into the cells, we get the same control over gene expression and downstream proliferation," says Smolke, who was named one of TR's young innovators of the year in 2002. (technologyreview.com)
  • A prerequisite for successful tissue engineering is adequate vascularization that would allow tissue engineering constructs to survive and grow. (mdpi.com)
  • To allow engineered tissue or organ constructs to survive and then thrive, a comprehensive network of healthy functional blood vessels is necessary for oxygen and nutrient delivery and waste product removal. (mdpi.com)
  • T-cell responses, evaluated by assessing delayed-type hypersensitivity (DTH) reactions against untransduced autologous tumor cells, were evident in two of eight patients before vaccination and in seven of eight patients after treatment. (aacrjournals.org)
  • A distinctive eosinophilic vasculitis was evident near autologous tumor cells at vaccine sites, and at DTH sites. (aacrjournals.org)
  • Prismatic deflection of live tumor cells and cell clusters. (nature.com)
  • IRE removes tumors by irreversibly opening tumor cells through a series of short intense electric pulses from small electrodes placed in or around the body," said Davalos, who is the 2006 recipient of the Hispanic Engineer National Achievement Award for Most Promising Engineer or Scientist. (innovations-report.com)
  • When injected into mice, immune cells modified to carry a molecular "on-off switch" (right) survive and grow much more effectively than animals given normal T cells (left). (technologyreview.com)
  • They will also explore whether treatments that showed benefits in mice when paired with the engineered lymphocytes will deliver in humans. (scientificamerican.com)
  • In mice that had been receiving antiretroviral medications, the enhanced T cells delayed the infection's ability to rebound once treatment was stopped. (courthousenews.com)
  • Lab mice are also engineered to have a genetic disposition to cancer, whereas environmental factors are often involved in the case of humans. (newscientist.com)
  • Destroying B cells, like the one shown here, helped mice with lupus revert to good health. (sciencemag.org)
  • After the mice got sick, the team exposed them to whole-body radiation to wipe out existing immune cells. (sciencemag.org)
  • In 26 of the mice, the CAR-T cells successfully destroyed the B cells with CD19-nearly all of them-and those cells never reappeared. (sciencemag.org)
  • Takebe's and Taniguchi's research team already demonstrated the ability to use a "self-condensation" cell culture process using iPS cells to tissue engineer three-dimensional human liver organoids that can vascularize after transplant into laboratory mice. (cincinnatichildrens.org)
  • In the study, the engineered blood stem cells were placed into human thymus tissue that had been implanted in the mice, allowing Zack and his team to study the human immune system reaction to melanoma in a living organism. (scienceblog.com)
  • In a recent study published in Genes & Development , Smogorzewska and her coworkers engineered mice that lack one of the genes involved in the repair process. (medicalnewstoday.com)
  • These mice turned out to be particularly susceptible to drugs that induce DNA cross-links, because their cells don't have a functional DNA repair system. (medicalnewstoday.com)
  • Sera from three of eight vaccinated men contained new antibodies recognizing polypeptides of 26, 31, and 150 kDa in protein extracts from prostate cells. (aacrjournals.org)
  • Antibody secreting plasma cells are dedicated protein-producing machines that are responsible for neutralizing viruses and bacteria, but also can cause disease. (seattlechildrens.org)
  • One focus of the lab is to leverage this technology to build a cell therapy for protein delivery. (seattlechildrens.org)
  • First, these cells can produce protein indefinitely. (seattlechildrens.org)
  • Second, antibody-secreting B cells produce similar quantities of protein as industrial cell lines. (seattlechildrens.org)
  • Protein Micropatterning Techniques for Tissue Engineering and Stem Cell Research. (routledge.com)
  • Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling. (nature.com)
  • Protein barcodes enable high-dimensional single-cell CRISPR screens. (nature.com)
  • These features are exploited to engineer cells that form biofilms in response to DNA-damaging agents and cells that activate protein synthesis when the cell population reaches a critical density. (pnas.org)
  • The V. fischeri signaling pathway, which has been exploited to engineer whole-cell biosensors ( 32 , 33 ) and cell-cell communication ( 5 , 10 , 34 ) systems in E. coli , is used to program a strain (B2) that synthesizes a target protein when the cell population reaches a critical density. (pnas.org)
  • The kidney cells were engineered to express the protein reflectin A1 that is commonly found in the mantle of the female squids known as Doryteuthis opalescens. (forbes.com)
  • When you genetically engineer an isolated human embryonic cell, you can change its transparency by putting these protein particles inside. (forbes.com)
  • Although CAR-T therapy can target different cells, the approved treatments hunt down and destroy B cells by spotting a protein marker, CD19, that almost all B cells sport on their surface. (sciencemag.org)
  • The present review will discuss how investigators have approached the challenge of neovascularization in tissue engineering through protein therapy and angiogenic growth factors, as well as cell therapy through endothelial cells and endothelial progenitor cells. (mdpi.com)
  • These observations highlighted the need for engineering the glycosylation pathways in the host cells in order to produce recombinant protein drugs with optimal and consistent glycans. (a-star.edu.sg)
  • We seek a protein and cell engineer to join our Biologics Drug Discovery group. (aftercollege.com)
  • As an active participant on multiple discovery program teams simultaneously, the candidate will represent our function regarding overall strategy and goals, especially around design and execution of recombinant protein, antibody and cell aspects of the research. (aftercollege.com)
  • While cell lines have already been used safely to produce enzymes, oils and transgenic proteins, several concerns remain in how to keep cultured meat/protein products safe, according to the FDA and USDA. (foodengineeringmag.com)
  • The input could be any number of protein signals inside a cell and the output could be instructions for the cell to create a molecule that's easily detected by a researcher - as in the case of the green-glowing cancer cells. (stanford.edu)
  • In the sensor-actuator devices described in the study, the optional piece of the RNA that could be cut out contained a "stop" message that instructed cells to stop making a protein before it was complete. (stanford.edu)
  • The sensor-actuator device only made the drug-activating output protein when the cell was diseased. (stanford.edu)
  • Engineering a molecular control switch into immune cells could improve their therapeutic potential. (technologyreview.com)
  • In a Phase I human gene therapy trial, eight immunocompetent prostate cancer (PCA) patients were treated with autologous, GM-CSF-secreting, irradiated tumor vaccines prepared from ex vivo retroviral transduction of surgically harvested cells. (aacrjournals.org)
  • The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. (springer.com)
  • Among key obstacles to effective cardiac cell grafting are the cost of autologous stem cell-derived cardiomyocytes, the ethical implications of using embryonic stem cell (ESC) products, immunological barriers to allogeneic cells, functional maturation beyond just the correct lineage decision, and the lack of durable engraftment. (jci.org)
  • This framing may offer an apt description of pharma's relationship with software and biotech engineers, as R&D leaders appear keen to leverage data science and digital technology, but seem to be placing their most substantive bets on emerging biological technologies like cell therapy. (forbes.com)
  • Presented by the Society of Biological Engineering ( SBE ) and the International Society for Stem Cell Research ( ISSCR ) , this meeting brings together engineers, biologists, and clinicians who. (aiche.org)
  • Here, we demonstrate how an engineered genetic circuit can be used to construct cells that respond to biological signals in a predetermined and programmable fashion. (pnas.org)
  • We envision that engineered gene networks can be used as regulatory modules and interfaced with the cell's genetic circuitry as "plug-and-play" devices to execute specific programs in response to particular biological signals. (pnas.org)
  • i ) a signaling pathway (the biosensor module) that detects relevant signals and interfaces these signals to a regulatory circuit, ( ii ) an artificial genetic module (the regulatory circuit) capable of responding to the signals transmitted by the biosensor module, and directing output signals according to its engineered properties, and ( iii ) an output interface that converts the signals transmitted by the regulatory circuit into a biological response. (pnas.org)
  • Thus, understanding the biophysical relationships between stem cells and their extracellular environments will improve the ability to design complex biological systems through tissue engineering. (nih.gov)
  • Major discoveries from his laboratory have centered on the control of cell fate and tissue formation in contract with materials that are tunable in both their biological content and mechanical properties. (berkeley.edu)
  • Molecular communication allows networking of nanomachines and potentially enables new applications in various domains including health (e.g., nanomedicine and tissue engineering), the environment (e.g., monitoring and quality control), ICT (Information Communication Technology)(e.g., implantable biological sensors and actuator networks), and military situations (e.g., biochemical sensing). (igi-global.com)
  • Biological systems like cells are complex and intertwined," said Choi, "so to understand the fundamental mechanisms behind them, we simplify and only study one or two basic mechanisms. (purdue.edu)
  • Chemotactic cell motility plays a critical role in many biological functions, such as immune response and embryogenesis. (purdue.edu)
  • After all, the shape of the silicon we put around the heart cells shouldn't matter much to the definition of life - how is this more a biological life form than those same heart cells just sitting in a pile in a dish? (extremetech.com)
  • It's alive, because those cells are alive, but unless that lump of cells is a biological life form, the stingray probably isn't, either. (extremetech.com)
  • It has been a great challenge to directly measure the cells changing mechanical properties continuously as the parasite matures inside the cell," said Suresh, the Ford Professor of Engineering, who also holds appointments in MIT s Department of Mechanical Engineering and Biological Engineering Division. (innovations-report.com)
  • In Friday's issue of Science , a Stanford researcher reported engineered biological "devices" that could one day offer these kinds of diagnostic and treatment options. (stanford.edu)
  • These autonomous biological tools are called "sensor-actuator" devices because they sense what's happening in a cell and act upon what they detect. (stanford.edu)
  • This helps us to see trends that we wouldn't normally see," said Bumsoo Han , a Purdue professor of mechanical engineering who builds models for studying how cancer cells move in biological systems. (purdue.edu)
  • For this study, a group led by Stephen Konieczny , a professor of biological sciences at Purdue, developed the pancreatic cell line in a mouse model. (purdue.edu)
  • Knowing the components of cells and how cells work is fundamental to all biological sciences while also being essential for research in biomedical fields such as cancer, and other diseases. (wikipedia.org)
  • His goals are to improve the diagnostic and therapeutic options available to trauma patients, and to establish new national and international networks - as can be seen in the 2006 launch of the Austrian Cluster for Tissue Regeneration and subsequent creation of the European Institute of Excellence for Tissue Engineering and Regenerative Medicine (Expertissue), which he co-founded. (springer.com)
  • Over this period, he has held faculty appointments (full time or adjunct) at the Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Baylor College of Medicine, University of North Carolina Chapel Hill, Duke University Medical Center, Louisiana State University Health Sciences Center New Orleans, and Tulane University Center for Stem Cell Research and Regenerative Medicine. (springer.com)
  • This method resulted in high yield of our target cell type, thyroid cells, but it may be applicable for the derivation of other clinically relevant cell types such as lung cells, insulin-producing cells, liver cells, etc.," explained Laertis Ikonomou, PhD, assistant professor of medicine at BUSM and member of the Center for Regenerative Medicine (CReM) at Boston Medical Center and BUSM. (eurekalert.org)
  • He also received funding from NASA for the devel-opment of advanced regenerative fuel cells. (sc.edu)
  • D. L. Coutu, M. François, and J. Galipeau, "Mesenchymal stem cells and tissue repair," in Regenerative Therapy Using Blood-Derived Stem Cells , D. Allan and D. Strunk, Eds. (hindawi.com)
  • Sourav Banerjee , assistant professor, Mechanical Engineering. (sc.edu)
  • Dr. Jim Fletcher, a UNF mechanical engineering professor and the principle investigator for all of the contracts, emphasized the potential for income to UNF through licensing of the UNF intellectual property and the other advantages that accrue from sponsored research programs. (unf.edu)
  • Dept. of Mechanical Engineering. (mit.edu)
  • Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2008. (mit.edu)
  • Mechanical engineers typically need a bachelor's degree in mechanical engineering or mechanical engineering technology. (myplan.com)
  • Fluorogenic oligonucleotide signaling probes also known as molecular beacons may be used to track genetic modifications in individual cells that that can be clonal expanded into a genetically engineered cell line. (wikipedia.org)
  • Bridging the gap between laboratory research and pilot plant scale insect culture/baculovirus technology, Insect Cell Culture Engineering is designed as a reference for biochemical and bioprocess engineers, bioprocess technologists, biochemists, molecular and cell biologists, microbiologists, and upper-level undergraduate and graduate students in these disciplines. (routledge.com)
  • We are working on optimized culture conditions and definition of molecular markers for quality control of mesenchymal stem cells. (ukaachen.de)
  • Aging of the organism as well as replicative senescence during culture expansion of stem cells is associated with various functional and molecular changes. (ukaachen.de)
  • This chapter provides a brief review of molecular communication, a networking paradigm inspired by cell communication mechanisms. (igi-global.com)
  • They were able to observe the movements of these cells using super-resolution microscopy , a powerful technique to observe very small molecular features. (purdue.edu)
  • We then extract the properties of a healthy red blood cell and a parasite-invaded cell from a combination of experiments and 3D computer modeling at the full-cell and molecular levels," he continued. (innovations-report.com)
  • Smolke and her team used the molecular devices to sense disease-like states, such as inflammation and cancer, in cultured human cells. (stanford.edu)
  • It involves, among other tasks, the reconstruction of the structure of interactions between molecular components, which is known as network inference or reverse engineering. (mdpi.com)
  • Each IGERT trainee will be guided by an advisory constellation of scholars drawn from over 30 faculty members from Engineering, Molecular Biosciences, Physical Sciences, Business, Public Policy, and Management. (igert.org)
  • These include non-small cell lung cancer and mesothelioma, pancreatic cancer, high-grade serous ovarian cancer and additional studies on AML. (eurekalert.org)
  • So, until recently, the head of MIT s Department of Materials Science and Engineering never thought he d be a player in the hunt for cures to malaria and pancreatic cancer. (innovations-report.com)
  • I am reminded of this regularly as my venture team* & I review the latest opportunities, or when I'm at a conference (like the annual meetings of the American Society for Cancer Research [AACR] or the American Society of Gene and Cell Therapy [ASGCT]), or when I'm fortunate enough to listen to Janelle Anderson on a podcast. (forbes.com)
  • Happily, Anderson has resurfaced - not only as the Chief Strategy Officer of the recently-announced Century Therapeutics (I am not an investor), a cancer cell therapy startup that launched this summer with an eye-popping $250M in the bank, but also as a guest on Luke Timmerman's always-excellent Long Run podcast . (forbes.com)
  • Her description of Century offers a prismatic example of what state of the art in immune-oncology cell therapy looks like today. (forbes.com)
  • The Cell Therapy and Cell Engineering Facility develops, validates, and implements procedures critical to gene transfer-related clinical research at Memorial Sloan Kettering. (mskcc.org)
  • CRISPR-enhanced engineering of therapy-sensitive cancer cells for self-targeting of primary and metastatic tumors. (news-medical.net)
  • An update on a mesothelioma study in which three patients with advanced, treatment-resistant disease have received the experimental T cell therapy. (eurekalert.org)
  • Among them: T cell therapy using TCR-engineered T cells induces tumor cell death, but this is only temporary as the tumor ultimately turns the T cells off. (eurekalert.org)
  • Enter CAR-T therapy, where T cells become efficient B cell slayers without needing a helping hand. (sciencemag.org)
  • Cell-based therapy using endothelial cells and their precursors presents an alternative approach to tackling this challenge. (mdpi.com)
  • namely to improve local circulation and encourage vascular ingrowth from the recipient to the graft, or to establish new local circulation through stem cell therapy. (mdpi.com)
  • The lab is exploring methods to reduce severe toxicities that are associated with CAR -T cell therapy, including cytokine release syndrome and neurotoxicity. (mayo.edu)
  • The lab is investigating applying the principles of CAR -T cell therapy to other cancers and autoimmune disease. (mayo.edu)
  • Despite the success and FDA approval of CAR -T cell therapy in hematological malignancies, the durable response rates are low, and most patients relapse within the first two years after CAR -T cell therapy. (mayo.edu)
  • Mechanisms of failure of CAR -T cell therapy include tumor escape, inhibition of T cells by tumor microenvironment and intrinsic T cell defects. (mayo.edu)
  • The main limiting toxicities after CAR -T cell therapy include the development of cytokine release syndrome (CRS) and neurotoxicity, which are life-threatening and can be fatal. (mayo.edu)
  • The laboratory team has utilized preclinical models and patient samples to gain insights into mechanisms of neurotoxicity post- CAR -T cell therapy, and to develop strategies to prevent and mitigate these toxicities. (mayo.edu)
  • The CAR-T cell treatment developed by Novartis and the University of Pennsylvania is the first type of gene therapy to hit the U.S. market - and one in a powerful but expensive wave of custom-made 'living drugs' being tested against blood cancers and some other tumours, too. (cbc.ca)
  • This is a brand new way of treating cancer,' said Dr. Stephan Grupp of Children's Hospital of Philadelphia, who treated the first child with CAR-T cell therapy - a girl who'd been near death but now is cancer-free for five years and counting. (cbc.ca)
  • CAR-T treatment uses gene therapy techniques not to fix disease-causing genes but to turbocharge T cells, immune system soldiers that cancer too often can evade. (cbc.ca)
  • CAR-T therapy is a complex process: first, a patient's white blood cells are removed and, where necessary, shipped to a specialised laboratory in temperature-controlled containers. (wired.co.uk)
  • At present, the industry continues to learn more about the management of CAR T cell therapy. (wired.co.uk)
  • This method uses CAR T-cell therapy and combines it with antibody specificity. (israel21c.org)
  • A stem cell based therapy offers promise for this goal, by providing an inexhaustible source of protected, HIV specific immune cells that would provide constant surveillance and potential eradication of the virus in the body. (ca.gov)
  • Historically, engineered genetic circuits were inspired by circuit design in electronics, following a similar approach using transcription factors, proteins that induce DNA conversion to RNA, which is tricky to work with because it's hard to predict an entirely new strand of genetic code. (bu.edu)
  • Consolidating and expanding current, fundamental notions of virology and animal cell cultivation, this practical reference examines the development of insect cell culture techniques for the production of recombinant proteins and insect pathogenic viruses. (routledge.com)
  • Because the switch is made from RNA rather than proteins, it may also avoid another issue with existing modified T cells-triggering an attack from the immune system. (technologyreview.com)
  • Many cancer cells produce proteins that suppress nearby T cell activity, rendering the immune response futile. (eurekalert.org)
  • After specifically working on reflectin proteins that play a critical role in how squids change color, they had a breakthrough that led to their study on how biotechnology can help in engineering human cells to become transparent getting published in Nature Communications. (forbes.com)
  • Many questions remain to be answered as to how exactly the IGF system mediates its effects both in normal and tumour cells and how the IGF-1R interacting proteins and downstream signalling cascades are regulated. (booktopia.com.au)
  • Proteins such as EPO require high levels of sialylation on their N-glycans as the lack of sialylation results in their rapid removal from the circulation by liver cells. (a-star.edu.sg)
  • Primary responsibilities will include the support of discovery research projects through the design and expression of recombinant proteins including antibodies, and cell engineering for function-based candidate screening (for example, reporter lines or genetic deletions). (aftercollege.com)
  • Experience engineering proteins for specific functional goals, including engineering of antibodies or extracellular ligands, and studying of signaling and membrane trafficking, is a plus. (aftercollege.com)
  • By studying the array of proteins endogenously in developing heart we now will shift our focus on re-engineering this environment in-vitro to be able to mimic this growth to use this as a mean to grow and expand these progenitors for use clinically in the future. (ca.gov)
  • Cell cultures have been used for some time, creating substances that can be used as food ingredients (e.g., enzymes, oils and transgenic proteins), cells that can be consumed directly or new plant varieties produced by biotechnology. (foodengineeringmag.com)
  • USDA and FDA have formally agreed to address the regulatory oversight of meat proteins produced by cell-cultured lines of livestock and poultry. (foodengineeringmag.com)
  • let the cells develop so those proteins are worked into its entire structure, and you've got a light-sensitive cell. (extremetech.com)
  • His team, along with NUS microbiologist Kevin Tan and NUS graduate student Qie Lan, is also collaborating with the Institut Pasteur in Paris to explore how specific proteins transported from the surface of parasite to the cell contribute to changes in cell mechanical properties and stickiness. (innovations-report.com)
  • The proteins these devices detect are chemical messengers, communicating information gathered inside and outside of the cell into the nucleus, which acts like the cell's control center. (stanford.edu)
  • The other integrin, called áVâ3, behaves much like áIIbâ3, in that it causes platelets to stick to certain proteins on the outside of the cell. (sciencecodex.com)
  • We wanted to see if we could differentiate between the two integrins using two different peptides - and, in fact, we can," notes co-senior author Joel Bennett, MD, Professor of Medicine, who works with proteins and cells important in clotting. (sciencecodex.com)
  • The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. (springer.com)
  • Equine mesenchymal stromal cells (MSCs) are increasingly investigated for their clinical therapeutic utility. (biomedcentral.com)
  • Quality control and biosafety testing of clinical reagents and patient cells. (mskcc.org)
  • The T cells developed at NCI have been licensed to Kite Pharmaceuticals, and a similar approach developed at the University of Pennsylvania, which has the most clinical data so far, has been licensed to Novartis. (medscape.com)
  • While several attempts to re-engineer T cells to fight the virus have been pursued, only one made it to the clinical testing phase and was not ultimately approved for widespread use. (courthousenews.com)
  • These encouraging results could open the door for clinical testing of T-cell re-engineering using the updated CAR, according to the team. (courthousenews.com)
  • The scope of activities includes the expansion of genetically engineered and non-engineered patient and donor cells, the manufacture of viral, bacterial, and plasmid DNA vectors, clinical cell purification, and extensive QA/QC oversight. (mskcc.org)
  • SEATTLE AND NEW ORLEANS - Dr. Philip Greenberg , head of immunology and a member of the Clinical Research Division at Seattle's Fred Hutchinson Cancer Research Center and a leader in cancer immunology, will describe how he and colleagues are genetically engineering T cells to seek out cancer cells, penetrate their defenses and kill them. (eurekalert.org)
  • An antibody called rituximab, which depletes B cells and is often prescribed to patients with rheumatoid arthritis and multiple sclerosis, failed to help many people with lupus in two large clinical trials. (sciencemag.org)
  • Therefore, overcoming the challenges of neovascularization is critical in the clinical applicability of tissue engineering. (mdpi.com)
  • These cells are currently tested in a broad range of clinical trials for tissue engineering. (ukaachen.de)
  • A platform for in-house production of CAR -T cells for clinical trials. (mayo.edu)
  • A team of biomedical engineers at Virginia Tech and the University of California at Berkeley has developed a new minimally invasive method of treating cancer, and they anticipate clinical trials on individuals with prostate cancer will begin soon. (innovations-report.com)
  • Tumour cells have a remarkable homing ability which enables them to travel from a distant location to a tumour site, whereby facilitating the congregation of tumour cells at the new site. (news-medical.net)
  • When introduced into the body the tumour cells are drawn to tumour sites, delivering the treatment exactly where it is required. (news-medical.net)
  • The approach can be employed using either pre-engineered tumour cells, which need to be tissue-matched to the recipient patient, or tumour cells harvested from a patient's tumour, which can be genetically modified and reintroduced. (news-medical.net)
  • In both cases the engineered tumour cells travelled directly and specifically to the sites of tumours. (news-medical.net)
  • The 'kill switch' that had been incorporated into the genome of the modified tumour cells was then activated. (news-medical.net)
  • She trained as a postdoctoral scientist at Columbia University, New York, USA, and was leading the bone regeneration group at the New York Stem Cell Foundation Research Institute, New York, USA. (springer.com)
  • Her research in bone tissue engineering and regeneration was supported by fellowships and grants from the Republic of Slovenia, New York Stem Cell Foundation, FFG Austria, and European Commission (Horizon 2020). (springer.com)
  • Richard O. C. Oreffo is Professor of Musculoskeletal Science and Co-founder/Director of the Centre for Human Development, Stem Cells and Regeneration at the University of Southampton. (springer.com)
  • The preeminent, biomedical journal bringing together the principles of engineering and life sciences to advance the field with cutting-edge research and applications on all aspects of tissue growth and regeneration. (liebertpub.com)
  • Additionally, fibrin gel has been utilized as a cell carrier to protect cells from the forces during the application and cell delivery processes while enhancing the cell viability and tissue regeneration. (hindawi.com)
  • Cardiac muscle restitution, or true regeneration, is an unmet need in the treatment of myocardial infarction (MI), prompting a decade of study with stem cells of many kinds. (jci.org)
  • The potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized the high-tech biomedical research. (springer.com)
  • Since various research groups within the Department of Biomedical Engineering use these facilities, a rich cross-fertilization of ideas and knowledge takes place. (tue.nl)
  • The laboratory is used mainly by research groups and the research partners of the Department of Biomedical Engineering. (tue.nl)
  • A significant portion of biomedical applications necessitates the establishment of an interface between the cells of the patient and the components of the device. (routledge.com)
  • David Odde, a professor of biomedical engineering at the University of Minnesota, hailed the research as exciting, especially since antibiotic resistance is on the rise. (baltimoresun.com)
  • The process, called irreversible electroporation (IRE), was invented by two engineers, Rafael V. Davalos, a faculty member of the Virginia Tech-Wake Forest University School of Biomedical Engineering and Science (SBES), and Boris Rubinsky, a bioengineering professor at the University of California, Berkeley. (innovations-report.com)
  • They reported the in vivo experiments in the June 2006 IEEE Transactions on Biomedical Engineering. (innovations-report.com)
  • Our immune system, it turns out, is engaged in a constant battle against cancerous cells that are continuously popping up, and which the immune system (mercifully) is usually able to destroy. (forbes.com)
  • Much of this focus has been on ways to reengineer one of the key elements of the immune system, the "effector T cell," which is responsible for killing cells it recognizes as being cancerous. (forbes.com)
  • The recognition that our immune system has remarkable potential to fight cancer - research recognized by the Nobel Assembly last year -- led to the development of FDA-approved therapeutics that work by juicing our existing cells, essentially by blocking the "stand down" order that ordinarily restrains the attack. (forbes.com)
  • That limits the cells' ability to recruit other parts of the immune system to kill the cancer. (technologyreview.com)
  • The ability of Salmonella to live in these areas has inspired Hasty's team to engineer strains of these bacteria to produce three types of cancer-killing drug: one that destroys cell walls, one that alerts the body's immune system, and one that triggers cells to die. (newscientist.com)
  • The cells have to sense something that the immune system has failed to sense. (baltimoresun.com)
  • It involves genetically engineering T cells, the sentries of the immune system, so they recognize and destroy certain cells in the body. (sciencemag.org)
  • This approach to immune system engineering has intriguing implications, Zack said. (scienceblog.com)
  • The human body's immune system is a remarkable thing: our white blood cells can fight off viruses, bacteria, all but the most virulent invaders. (wired.co.uk)
  • Immunotherapy, on the other hand, uses the body's own immune system to seek out and destroy cancer cells. (israel21c.org)
  • At the University of South Carolina, a team of faculty and students are focused on various aspects of fuel cell research from design and performance to hydrogen storage. (sc.edu)
  • HeteroFoaM technology can then be used to enable clean energy conversion and storage devices such as fuel cells, hydrogen generators, capacitors, batteries and separation membranes. (sc.edu)
  • Dr. Benicewicz's work is focused on the development of new high temperature polymer membranes which has resulted in the commercial development of fuel cell units for homes and portable power devices and is now being extend-ed into hydrogen purification and generation applications. (sc.edu)
  • Research is also performed on reforming technologies for fuel cell feeds, hydrogen generation and storage, and development of high-temperature corrosion resistant materials. (sc.edu)
  • Environmentally, the fuel cell is an improvement on the battery because, in consuming hydrogen, the only exhaust emission is harmless steam. (theengineer.co.uk)
  • The PEM fuel cell then converts the hydrogen gas into electricity. (theengineer.co.uk)
  • forum804 - Professional forum and technical support for engineers for Hydrogen and related fuel cell engineering. (eng-tips.com)
  • It is possible to reform both methanol and ethanol to produce hydrogen to feed a conventional PEM fuel cell. (eng-tips.com)
  • This is why, in part, we sought solutions of the style of fuel cells, since in general, running with hydrogen or even reforming natural gas yield better yields. (eng-tips.com)
  • We know that it is not a simple solution and we are aware of problems such as those named moltenmetal, but we have seen that some companies already offer some advanced prototype, which is based on the reform of ethanol in hydrogen, and feeding a cell with this hydrogen. (eng-tips.com)
  • Keith Wipke of the U.S. Department of Energy's National Renewable Energy Laboratory was recently elected to the Board of Directors of the Fuel Cell and Hydrogen Energy Association (FCHEA). (nrel.gov)
  • I am looking forward to helping this organization achieve its goals of market introduction and success for hydrogen and fuel cell technologies," Wipke said. (nrel.gov)
  • I personally would like to see hydrogen fuel cell cars stay on track for 2015 introduction to consumers, with enough fueling stations to make consumers comfortable with fuel availability. (nrel.gov)
  • FCHEA is dedicated to the commercialization of fuel cells and hydrogen energy technologies. (nrel.gov)
  • Among various potential approaches, this chapter is devoted to the device physics and development of the state-of-the-art technologies for quantum dot-based IB solar cells. (igi-global.com)
  • D. L. Hutton and W. L. Grayson, "Stem cell-based approaches to engineering vascularized bone," Current Opinion in Chemical Engineering , vol. 3, pp. 75-82, 2014. (hindawi.com)
  • Hence, different approaches are being put forward to overcome this drawback which should also take into account the viability of the immobilised cells. (mdpi.com)
  • Recently, stem/progenitor cells have been identified in TMJ disc and condyle, with potential origin from neural crest cells in development. (redorbit.com)
  • Putative TMJ stem/progenitor cells are subjected to local, hormonal and other systemic factors in homeostasis in multiple processes that warrant better elucidation. (redorbit.com)
  • The tissue-engineering process also uses two types of embryonic-stage progenitor cells, which support formation of the body and its specific organs. (cincinnatichildrens.org)
  • The progenitor cells are mesenchymal stem cells (MSNs) and human umbilical vascular endothelial cells (HUVECs). (cincinnatichildrens.org)
  • A) Culture expansion of hematopoietic stem and progenitor cells (CD34+ cells, HSCs) on plastic or mesenchymal stromal cells (MSCs). (ukaachen.de)
  • Cancer initiating cells are often derived from stem and progenitor cells. (ukaachen.de)
  • Overall objective is to identify the best conditions for expansion of human PSC derived cardiac progenitor cells and to push them towards a ventricular cardiomyocyte lineage for transplantation studies. (ca.gov)
  • There has been increased attention towards developing tissue engineering as a method to standardize methods to differentiate human ESCs and iPSCs into cardiovascular progenitor cells (CPC) expand these progenitor cells in a standardized manor. (ca.gov)
  • The 150-kDa polypeptide was expressed by LNCaP and PC-3 PCA cells, as well as by normal prostate epithelial cells, but not by prostate stromal cells. (aacrjournals.org)
  • We have developed DNA methylation signatures to define cell populations, e.g. pluripotent cells (Epi-Pluri-Score), mesenchymal stromal cells (Epi-MSC-Score), blood counts (Epi-Blood-Count), or prognostic biomarkers in various diseases. (ukaachen.de)
  • In this study, polycaprolactone (PCL) and polyethylene glycol (PEG) blend (PCL-PEG) together with alginate dialdehyde gelatine hydrogel (ADA-GEL) loaded with stromal cell line (ST2) were investigated. (mdpi.com)
  • HeteroFoaMs are heterogeneous functional materials at the heart of energy systems such as fuel cells, batteries and membranes. (sc.edu)
  • Combining gene editing and stem-cell induction improves efficiency of functional genetic analyses. (the-scientist.com)
  • All of this preceded the cell theory which states that all living things are made up of cells and that cells are the functional and structural unit of organisms. (wikipedia.org)
  • A stress field influences cell function primarily through deformation of the extracellular matrix to which cells are attached. (mit.edu)
  • Designing nanotopographical density of extracellular matrix for controlled morphology and function of human mesenchymal stem cells," Scientific Reports , vol. 3, article 3552, 2013. (hindawi.com)
  • The use of additive manufacturing techniques to fabricate complex tissue equivalents which combine living cells, extracellular matrix materials, growth factors and also structural elements is receiving increasing research interest [ 3 , 4 ]. (mdpi.com)
  • One approach is to isolate T cells-a type of white blood cell that helps tailor the body's response to specific pathogens-from a patient's blood, multiply them, and then inject them back into the patient. (technologyreview.com)
  • During treatment, T cells were extracted from a patient's blood and re-engineered in a lab to express HIV-specific CARs, before being infused back into the patient. (courthousenews.com)
  • When the magnetic field concentrators were placed underneath the culture substrates, micro-line patterning of human umbilical vein endothelial cells (HUVECs) labeled with MCLs was formed on a monolayer of cells or a magnetic tissue-engineered cell sheet constructed by accumulating MCL-labeled cells uniformly and three-dimensionally to the culture surface using magnetic force. (springer.com)
  • Endothelial cells (ECs) that form the capillary walls constitut. (biomedcentral.com)
  • Sprouting is a multistep process involving the dissolution of the basement membrane, the migration and proliferation of endothelial cells, the formation of a lumen and maturation of the new vessel with investment of the vessel with pericytes [ 3 ]. (mdpi.com)
  • In the Bioelectromechanical Systems Laboratory, other research projects associated with utilizing the physical and electrical characteristics of cells, such as engineering methods for microfluidic single cell analysis, selective cell concentration, and image-guided surgery, broaden the understanding and potential of the field of IRE. (innovations-report.com)
  • Cancer results from cells gone wild. (scientificamerican.com)
  • And the cancer-fighting T cells of a 30-year-old man dissipated a mass in his lung. (scientificamerican.com)
  • The modified cancer cells have demonstrated anti-cancer efficacy in preclinical studies, destroying both primary and metastatic tumours. (news-medical.net)
  • This overcomes the difficulty in delivering anti-cancer drugs specifically to the tumour site without damaging healthy cells. (news-medical.net)
  • With our technique, we show it is possible to reverse-engineer a patient's own cancer cells and use them to treat cancer. (news-medical.net)
  • The team at Brigham and Women's Hospital created CRISPR-enhanced, reverse-engineered cancer cells with a 'kill switch' to provide targeted treatment for destroying tumours. (news-medical.net)
  • Retrieved on June 18, 2019 from https://www.news-medical.net/news/20180712/Fighting-cancer-with-engineered-cancer-cells.aspx. (news-medical.net)
  • It looks like the disease has disappeared after a single infusion of these engineered T cells," commented James Kochenderfer, MD, from the Experimental Transplantation and Immunology Branch of the National Cancer Institute (NCI) in Bethesda, Maryland. (medscape.com)
  • CDT April 20 as part of a symposium on the function of T cells and their therapeutic application in cancer. (eurekalert.org)
  • T cells can also target cancer cells, but they sometimes fail to recognize cancer cells as the enemy. (eurekalert.org)
  • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. (nature.com)
  • Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. (nature.com)
  • Rosenberg, S.A. & Restifo, N.P. Adoptive cell transfer as personalized immunotherapy for human cancer. (nature.com)
  • Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions. (nature.com)
  • Over about six weeks, the engineered blood stem cells developed into a large population of mature, melanoma-specific T-cells that were able to target the right cancer cells. (scienceblog.com)
  • This new approach engineers the cells that give rise to the T-cells so that "fresh" cancer-killing cells could be generated when needed, perhaps protecting against cancer recurrence later. (scienceblog.com)
  • The peripheral T-cells would serve as the front-line cancer fighters, while the blood stem cells are creating a second wave of warriors to take up the battle as the front line T-cells are losing function. (scienceblog.com)
  • Opening a new era in cancer care, the U.S. Food and Drug Administration on Wednesday approved the first treatment that genetically engineers patients' own blood cells into an army of assassins to seek and destroy childhood leukemia. (cbc.ca)
  • We're entering a new frontier in medical innovation with the ability to reprogram a patient's own cells to attack a deadly cancer,' said FDA Commissioner Scott Gottlieb. (cbc.ca)
  • But when it comes to tackling cancer, they struggle: cancer cells are, from their perspective, part of the body. (wired.co.uk)
  • Zelig Eshhar and Gideon Gross described the first successful generation of a CAR-T cell in the lab 30 years ago," explains Markwin Velders, vice president of operations at Kite Pharma, a Gilead company, one of many working on this type of cancer treatment. (wired.co.uk)
  • Engineered T cells have been proven very successful in treating blood cancer but attempts to use them to fight solid cancers have been disappointing," he said. (israel21c.org)
  • What Davalos and Rubinsky did was apply this irreversible concept to the targeting of cancer cells. (innovations-report.com)
  • Imagine if your doctor could look for cancer in your body just by checking for green glowing cells, alerting her to the presence of the disease. (stanford.edu)
  • Cancer is a disease of the cells, which are the body's basic building blocks. (cancervic.org.au)
  • Start experimenting immediately - Find 1000's of validated knockout models, point mutations in cancer-relevant cell models, and Cas9 and dCas9-VPR expressing stable cell lines. (horizondiscovery.com)
  • Mesenchymal stem cells are precursors for osteocytes, chondrocytes and adipocytes. (ukaachen.de)
  • Engineering tubular bone using mesenchymal stem cell sheets and coral particles," Biochemical and Biophysical Research Communications , vol. 433, no. 4, pp. 595-601, 2013. (hindawi.com)
  • The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine," Nature Medicine , vol. 19, no. 1, pp. 35-42, 2013. (hindawi.com)
  • Small trials using younger donors and elderly recipients hint that mesenchymal stem cell transfers might reduce frailty. (the-scientist.com)
  • CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation. (nature.com)
  • Dr. Popov received funding from DOE and National Science Foundation (NSF) for the development of ultra-low loading platinum catalysts for polymer electrolyte membrane fuel cells. (sc.edu)
  • Each fuel cell consists of an electrolytic membrane placed between the positive and negative electrodes. (theengineer.co.uk)
  • The Fletcher Lab develops diagnostic technologies and studies mechanical regulation of membrane and cytoskeleton organization in the context of cell motility, signaling, and host-pathogen interactions. (berkeley.edu)
  • The second project, funded through the DOE Fuel Cell Technologies Program, works to improve the membrane electrode assembly, the key component of the power system, and make it even better. (unf.edu)
  • When the military laptop project started in August of 2009, UNF was partnering with PolyFuel Inc., a former world leader in portable fuel cell membrane technology. (unf.edu)
  • Prokaryotic cells are distinguished from eukaryotic cells by the absence of a cell nucleus or other membrane bound organelle. (wikipedia.org)
  • Furthermore, our results raise the possibility that immortalized cell lines can be used for replacement of specific cell types and for the transport of genes to given locations in neuroretina. (pnas.org)
  • A handful of genes that are normally active in the developing embryo are expressed in a differentiated cell, such as a skin cell, causing that cell to revert back to its undifferentiated state. (technologyreview.com)
  • Much to their surprise, the human genes that are typically used to reprogram human cells could also reprogram skin cells from both the monkey and the rhinoceros, though at a much lower efficiency. (technologyreview.com)
  • By creating stem cells from animals that died, "their genes could be reintroduced to maintain the survival and genetic diversity of the species," says Lanza. (technologyreview.com)
  • Cell phenotypes are determined by the concerted activity of thousands of genes and their products. (psu.edu)
  • The genes integrate with the cell DNA and are permanently incorporated into the blood stem cells, theoretically enabling them to produce melanoma-fighting cells indefinitely and when needed, said Dimitrios N. Vatakis, the study's first author and an assistant researcher in Zack's lab. (scienceblog.com)
  • This type of DNA damage is particularly problematic for the cell because when the two strands stick together, DNA cannot replicate and genes cannot be properly expressed. (medicalnewstoday.com)
  • Some of the key players offering CRISPR based cell lines are GenScript, Horizon Discovery Group, CRISPR therapeutics, etc. to name some. (webnewswire.com)
  • Therapeutics derived from this approach are a long way off, but this method allows us to now study these interactions that are so fundamental to the way in which cells cooperate to carry out essential functions," says Bennett. (sciencecodex.com)
  • Bacteria could prove useful new recruits in the battle, armed with poisons and engineered to self-destruct after completing their mission. (newscientist.com)
  • A team at the Johns Hopkins University Whiting School of Engineering are working to engineer amoeba cells to seek out and eat deadly bacteria. (baltimoresun.com)
  • Douglas said they want the engineered cells to respond to dangerous bacteria the way a human might respond to the smell of a freshly baked plate of cookies - to immediately crave a cookie, walk into the kitchen and eat some. (baltimoresun.com)
  • I think getting the cells to sense the bacteria robustly might be a challenge, and I'm sure they're aware of that," he said. (baltimoresun.com)
  • Prokaryotic cells include Bacteria and Archaea, and lack an enclosed cell nucleus. (wikipedia.org)
  • Bacteria can be classed as either gram positive or gram negative depending on the cell wall composition. (wikipedia.org)
  • Second, the process inserts a viral vector mechanism into the cells which - once the cells have latched on to the leukemia - triggers these T cells to expand and proliferate, so that they seek out and destroy all the remaining leukemic cells. (medscape.com)
  • This method may serve as a principal curative strategy for treating type 1 diabetes, of which there are 79,000 new diagnoses per year," said Takanori Takebe, MD , a physician-scientist at the Cincinnati Children's Center for Stem Cell and Organoid Medicine . (cincinnatichildrens.org)
  • Suresh s coauthors are graduate student John P. Mills and research scientist Ming Dao of MIT s Department of Materials Science and Engineering, Professor Joachim Spatz and Alexandre Micoulet of the University of Heidelberg, Professor C. T. Lim of NUS, and Professor Thomas Seufferlein and Mark Beil of the University of Ulm. (innovations-report.com)
  • This was ultimately concluded by plant scientist, Matthias Schleiden and animal scientist, Theodor Schwann in 1838, who viewed live cells in plant and animal tissue, respectively. (wikipedia.org)