Cell Engineering: Methods and techniques used to modify or select cells and develop conditions for growing cells for biosynthetic production of molecules (METABOLIC ENGINEERING), for generation of tissue structures and organs in vitro (TISSUE ENGINEERING), or for other BIOENGINEERING research objectives.Tissue Engineering: Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Biocompatible Materials: Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.Regenerative Medicine: A field of medicine concerned with developing and using strategies aimed at repair or replacement of damaged, diseased, or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.Stem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Embryonic Stem Cells: Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.Bioelectric Energy Sources: Electric power supply devices which convert biological energy, such as chemical energy of metabolism or mechanical energy of periodic movements, into electrical energy.Electricity: The physical effects involving the presence of electric charges at rest and in motion.Journalism, Medical: The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.Psychiatry: The medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders.Library Services: Services offered to the library user. They include reference and circulation.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Cardiology: The study of the heart, its physiology, and its functions.Hospital Restructuring: Reorganization of the hospital corporate structure.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.New Orleans: City in Orleans Parish (county), largest city in state of LOUISIANA. It is located between the Mississippi River and Lake Pontchartrain.LouisianaGraft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Cyclonic Storms: Non-frontal low-pressure systems over tropical or sub-tropical waters with organized convection and definite pattern of surface wind circulation.BaltimoreScience: The study of natural phenomena by observation, measurement, and experimentation.Social Sciences: Disciplines concerned with the interrelationships of individuals in a social environment including social organizations and institutions. Includes Sociology and Anthropology.Universities: Educational institutions providing facilities for teaching and research and authorized to grant academic degrees.Research Personnel: Those individuals engaged in research.United StatesBacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Neural Stem Cells: Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. Neural stem cells are precursors to both NEURONS and NEUROGLIA.Hydrogel: A network of cross-linked hydrophilic macromolecules used in biomedical applications.Pluripotent Stem Cells: Cells that can give rise to cells of the three different GERM LAYERS.Induced Pluripotent Stem Cells: Cells from adult organisms that have been reprogrammed into a pluripotential state similar to that of EMBRYONIC STEM CELLS.Clustered Regularly Interspaced Short Palindromic Repeats: Repetitive nucleic acid sequences that are principal components of the archaeal and bacterial CRISPR-CAS SYSTEMS, which function as adaptive antiviral defense systems.CRISPR-Associated Proteins: Protein components of the CRISPR-CAS SYSTEMS for anti-viral defense in ARCHAEA and BACTERIA. These are proteins that carry out a variety of functions during the creation and expansion of the CRISPR ARRAYS, the capture of new CRISPR SPACERS, biogenesis of SMALL INTERFERING RNA (CRISPR or crRNAs), and the targeting and silencing of invading viruses and plasmids. They include DNA HELICASES; RNA-BINDING PROTEINS; ENDONUCLEASES; and RNA and DNA POLYMERASES.Inverted Repeat Sequences: Copies of nucleic acid sequence that are arranged in opposing orientation. They may lie adjacent to each other (tandem) or be separated by some sequence that is not part of the repeat (hyphenated). They may be true palindromic repeats, i.e. read the same backwards as forward, or complementary which reads as the base complement in the opposite orientation. Complementary inverted repeats have the potential to form hairpin loop or stem-loop structures which results in cruciform structures (such as CRUCIFORM DNA) when the complementary inverted repeats occur in double stranded regions.CRISPR-Cas Systems: Adaptive antiviral defense mechanisms, in archaea and bacteria, based on DNA repeat arrays called CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS (CRISPR elements) that function in conjunction with CRISPR-ASSOCIATED PROTEINS (Cas proteins). Several types have been distinguished, including Type I, Type II, and Type III, based on signature motifs of CRISPR-ASSOCIATED PROTEINS.Genetic Engineering: Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.RNA, Guide: Small kinetoplastid mitochondrial RNA that plays a major role in RNA EDITING. These molecules form perfect hybrids with edited mRNA sequences and possess nucleotide sequences at their 5'-ends that are complementary to the sequences of the mRNA's immediately downstream of the pre-edited regions.Protein Engineering: Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.Laboratories: Facilities equipped to carry out investigative procedures.Molecular Biology: A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.Microbiology: The study of microorganisms such as fungi, bacteria, algae, archaea, and viruses.United States Public Health Service: A constituent organization of the DEPARTMENT OF HEALTH AND HUMAN SERVICES concerned with protecting and improving the health of the nation.Medical Laboratory Personnel: Health care professionals, technicians, and assistants staffing LABORATORIES in research or health care facilities.TennesseeSwitzerlandSocieties, Medical: Societies whose membership is limited to physicians.Governing Board: The group in which legal authority is vested for the control of health-related institutions and organizations.Factor XIII: A fibrin-stabilizing plasma enzyme (TRANSGLUTAMINASES) that is activated by THROMBIN and CALCIUM to form FACTOR XIIIA. It is important for stabilizing the formation of the fibrin polymer (clot) which culminates the coagulation cascade.Awards and PrizesAdvisory Committees: Groups set up to advise governmental bodies, societies, or other institutions on policy. (Bioethics Thesaurus)Trustees: Board members of an institution or organization who are entrusted with the administering of funds and the directing of policy.

Engineering supported membranes for cell biology. (1/57)

 (+info)

Influence of collagen and chondroitin sulfate (CS) coatings on poly-(lactide-co-glycolide) (PLGA) on MG 63 osteoblast-like cells. (2/57)

Poly-(lactide-co-glycolide) (PLGA) is an FDA-approved biodegradable polymer which has been widely used as a scaffold for tissue engineering applications. Collagen has been used as a coating material for bone contact materials, but relatively little interest has focused on biomimetic coating of PLGA with extracellular matrix components such as collagen and the glycosaminoglycan chondroitin sulfate (CS). In this study, PLGA films were coated with collagen type I or collagen I with CS (collagen I/CS) to investigate the effect of CS on the behaviour of the osteoblastic cell line MG 63. Collagen I/CS coatings promoted a significant increase in cell number after 3 days (in comparison to PLGA) and after 7 days (in comparison to PLGA and collagen-coated PLGA). No influence of collagen I or collagen I/CS coatings on the spreading area after 1 day of culture was observed. However, the cells on collagen I/CS formed numerous filopodia and displayed well developed vinculin-containing focal adhesion plaques. Moreover, these cells contained a significantly higher concentration of osteocalcin, measured per mg of protein, than the cells on the pure collagen coating. Thus, it can be concluded that collagen I/CS coatings promote MG 63 cell proliferation, improve cell adhesion and enhance osteogenic cell differentiation.  (+info)

Concise review: Human cell engineering: cellular reprogramming and genome editing. (3/57)

 (+info)

Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells. (4/57)

 (+info)

Introduction to induced pluripotent stem cells: advancing the potential for personalized medicine. (5/57)

 (+info)

Integration-free iPS cells engineered using human artificial chromosome vectors. (6/57)

 (+info)

Experimental evolution of a facultative thermophile from a mesophilic ancestor. (7/57)

 (+info)

Glycoengineering of HCELL, the human bone marrow homing receptor: sweetly programming cell migration. (8/57)

 (+info)

*Confocal microscopy

"The Journal of Cell Biology. 105 (1): 41-48. doi:10.1083/jcb.105.1.41. ISSN 0021-9525. PMC 2114888 . PMID 3112165.. ... Zyun Koana (1942). Journal of the Illumination Engineering Institute. 26 (8): 371-385.. Missing or empty ,title=. (help) The ... Amos, W.B.; White, J.G. (2003). "How the Confocal Laser Scanning Microscope entered Biological Research". Biology of the Cell. ... CLSM is widely used in numerous biological science disciplines, from cell biology and genetics to microbiology and ...

*Leukocyte extravasation

"Microfluidic devices for modeling cell-cell and particle-cell interactions in the microvasculature". Microvascular Research. 82 ... Dept of Biomedical Engineering, University of Virginia. "Inflammation: The Leukocyte Adhesion Cascade".. ... For a catch-bond, the force on the cell pulls the adhesive tip of a fimbria to close tighter on its target cell. As the ... white blood cells). The binding of PSGL-1 on the leukocyte to P-selectin on the endothelial cell allows for the leukocyte to ...

*Lead(II,IV) oxide

Red lead was used for engineer's scraping, before being supplanted by engineer's blue. ...

*Annual Reviews (publisher)

Annual Review of Cell and Developmental Biology (1985). *Annual Review of Chemical and Biomolecular Engineering (2010) ...

*Kim Nasmyth

Here he worked on the cell cycle alongside Paul Nurse and his PhD thesis focused on the control of DNA replication in fission ... He is a member of the Advisory Council for the Campaign for Science and Engineering. His research has been funded by the ... He is best known for his work on the segregation of chromosomes during cell division. Nasmyth was born in London in 1952 of ... At the IMP, Nasmyth changed his focus from gene silencing back to cell cycle control. In the mid-1990s Nasmyth co-discovered ...

*Genome editing

Modified donor T cells were engineered to attack the leukemia cells, to be resistant to Alemtuzumab, and to evade detection by ... "Development and Applications of CRISPR-Cas9 for Genome Engineering". Cell. 157 (6): 1262-1278. doi:10.1016/j.cell.2014.05.010. ... These T-cells can be engineered to be resistant to anti-cancer drugs and to invoke immune responses against targets of interest ... The US company Sangamo BioSciences uses zinc finger nucleases to carry out research into the genetic engineering of stem cells ...

*Myosin binding protein C, cardiac

Disease-modeling by engineered heart tissue (EHT) technology with cardiac cells from heterozygous or homozygous Mybpc3-targeted ... Hsu PD, Lander ES, Zhang F (Jun 2014). "Development and applications of CRISPR-Cas9 for genome engineering". Cell. 157 (6): ... Cell Stem Cell. 12 (1): 101-13. doi:10.1016/j.stem.2012.10.010. PMC 3638033 . PMID 23290139. Han L, Li Y, Tchao J, Kaplan AD, ... doi:10.1016/j.cell.2014.05.010. PMC 4343198 . PMID 24906146. Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F (Nov 2013 ...

*Restriction enzyme

Hsu PD, Lander ES, Zhang F (June 2014). "Development and applications of CRISPR-Cas9 for genome engineering". Cell. 157 (6): ... Stetson DB, Ko JS, Heidmann T, Medzhitov R (Aug 2008). "Trex1 prevents cell-intrinsic initiation of autoimmunity". Cell. 134 (4 ... The host cell, in this example E. coli K, is known as the restricting host and appears to have the ability to reduce the ... doi:10.1016/j.cell.2008.06.032. PMC 2626626 . PMID 18724932. Gasior SL, Roy-Engel AM, Deininger PL (Jun 2008). "ERCC1/XPF ...

*Zinc finger nuclease

2011). "Engineering HIV-resistant humant CD4+ T cells with CXCR4-specific zinc-finger nucleases". PLoS Pathogens. 7: e1002020. ... Cell. 31 (2): 294-301. doi:10.1016/j.molcel.2008.06.016. PMC 2535758 . PMID 18657511. Carroll, D (2011). "Genome engineering ... After editing the stem cell genome, the cells could be expanded in culture and reinserted into the patient to produce ... Several groups are also developing other types of engineered nucleases including engineered homing endonucleases and nucleases ...

*Site-directed mutagenesis

"Development and applications of CRISPR-Cas9 for genome engineering". Cell. 157 (6): 1262-78. doi:10.1016/j.cell.2014.05.010. ... The gene thus copied contains the mutated site, and is then introduced into a host cell as a vector and cloned. Finally, ... The dUTPase deficiency prevents the breakdown of dUTP, resulting in a high level of dUTP in the cell. The uracil deglycosidase ... Estell DA, Graycar TP, Wells JA (10 June 1985). "Engineering an enzyme by site-directed mutagenesis to be resistant to chemical ...

*Protospacer adjacent motif

"Structure and Engineering of Francisella novicida Cas9". Cell. 164 (5): 950-961. doi:10.1016/j.cell.2016.01.039. PMC 4899972 . ... Cell. 163 (3): 759-771. doi:10.1016/j.cell.2015.09.038. PMID 26422227. Fonfara I, Richter H, Bratovič M, Le Rhun A, Charpentier ... Attempts have been made to engineer Cas9s to recognize different PAMs to improve ability of CRISPR-Cas9 to do gene editing at ... Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, Norville JE, Church GM (2013). "RNA-guided human genome engineering via ...

*Hammerhead ribozyme

Work is also underway to find out whether they could be used to engineer HIV-resistant lines of T-cells. Modified hammerhead ... Cell. Biol. 18 (7): 3880-3888. PMC 108972 . PMID 9632772. Rojas AA, Vazquez-Tello A, Ferbeyre G, Venanzetti F, Bachmann L, ... doi:10.1016/j.cell.2006.06.036. PMID 16859740. Citti L, Rainaldi G (2005). "Synthetic hammerhead ribozymes as therapeutic tools ... Subsequently, an all-RNA minimal hammerhead ribozyme structure was published by Scott, Finch and Klug in Cell in early 1995. ...

*UDP-glucose 4-epimerase

Cell Biol. 9 (2): 151-61. doi:10.1038/nrm2334. PMID 18216771. Ten Hagen KG, Fritz TA, Tabak LA (January 2003). "All in the ... and protein engineering". Biochim. Biophys. Acta. 1543 (2): 275-293. doi:10.1016/s0167-4838(00)00232-6. PMID 11150611. Garner B ... Cell. 11 (3): 819-31. doi:10.1091/mbc.11.3.819. PMC 14813 . PMID 10712502. Breuza L, Garcia M, Delgrossi MH, Le Bivic A ( ... Cell Res. 273 (2): 178-86. doi:10.1006/excr.2001.5442. PMID 11822873. Naim HY, Joberty G, Alfalah M, Jacob R (June 1999). " ...

*Mutagenesis (molecular biology technique)

"Development and applications of CRISPR-Cas9 for genome engineering". Cell. 157 (6): 1262-78. doi:10.1016/j.cell.2014.05.010. ... Cells or organisms may be exposed to mutagens such as UV radiation or mutagenic chemicals, and mutants with desired ... Vector containing DNA sequence similar to the gene to be modified is introduced to the cell, and by a process of recombination ... Similar procedures may be repeated with other types of cells and with different media for selection. A number of methods for ...

*Argument from authority

Kevles, Daniel J. (1985). "Human Chromosomes--Down's Disorder and the Binder's Mistakes" (PDF). Engineering and Science: 9. T. ... C., Hsu (1979). "Out of the Dark Ages: Human and Mammalian Cytogenetics: An Historical Perspective" (PDF). Cell. Unger, ...

*Remote control animal

Cell. 121 (1): 6-7. doi:10.1016/j.cell.2005.03.010. PMID 15820673. Retrieved 12 December 2013. Huston, Caitlin (11 February ... 2013). "Automatic navigation for rat-robots with modeling of the human guidance". Journal of Bionic Engineering. 10 (1): 46-56 ... "Controllable Cyborg Beetles for Swarming Search and Rescue". IEEE Spectrum: Technology, Engineering, and Science News. ... solar cells and piezoelectrics that harvest energy from movement cannot provide enough power to run the electrodes and radio ...

*Leroy Hood

"A Cell-Surface Membrane Protein Signature for Glioblastoma". Cell Systems. 4 (5): 516-529.e7. doi:10.1016/j.cels.2017.03.004. ... His father was an electrical engineer, and his mother had a degree in home economics. Hood was one of four children, including ... Cell Genet. 39 (4): 246-9. doi:10.1159/000132152. PMID 2414074. Walters, LeRoy; Palmer, Julie Gage (1996). The ethics of human ... Leroy Hood is a member of the National Academy of Sciences (NAS, 1982), the National Academy of Engineering (2007), and the ...

*Synthetic biological circuit

doi:10.1016/j.cell.2009.04.048. Cheng, Allen A.; Lu, Timothy K. (2012-01-01). "Synthetic Biology: An Emerging Engineering ... synthetic cells can be developed implementing only the pathways necessary for cell survival reproduction. From this cell, to be ... Once the cells are induced, it is difficult to remove IPTG from the cells and therefore it is difficult to stop expression. An ... cells with well defined genetic circuitry can be engineered. It is widely believed that if a proper toolbox of parts is ...

*Restriction enzyme

"Development and applications of CRISPR-Cas9 for genome engineering". Cell. 157 (6): 1262-78. doi:10.1016/j.cell.2014.05.010 ... "Cell. 134 (4): 587-598. doi:10.1016/j.cell.2008.06.032. PMC 2626626. PMID 18724932.. ... The host cell, in this example E. coli K, is known as the restricting host and appears to have the ability to reduce the ... Primrose SB, Old RW (1994). Principles of gene manipulation: an introduction to genetic engineering. Oxford: Blackwell ...

*Ben G. Davis

... protein engineering; drug delivery; molecular biology; structural biology; cell biology; glycobiology; molecular imaging and in ... Research in the Davis laboratory has been funded by the Engineering and Physical Sciences Research Council (EPSRC), the ...

*EVI5L

Localization of proteins in yeast and animal cells Localization of proteins in yeast and animal cells: EVI5L TMHMM:Prediction ... Protein Engineering, Design & Selection. 17 (6): 527-36. doi:10.1093/protein/gzh062. PMID 15314210. Sano H, Eguez L, Teruel MN ... This is attributed to the requirement of RAB23 in the differentiation of cardiac progenitor cells. RAB23 is required for normal ... Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and ...

*List of universities in Karachi

Cell, IT. "Home - University of Education, Lahore". www.ue.edu.pk. "Dawood University Of Engineering & Technology Karachi". ... "Pakistan Naval Engineering College". Pakistan Naval Engineering College. Retrieved 2014-01-27. "Sindh Madresatul Islam ... "Sir Syed University of Engineering and Technology". Ssuet.edu.pk. Retrieved 2014-01-27. "PAF Karachi Institute of Economics & ... Karachi DHA Suffa University Fatima Jinnah Dental College Institute of Industrial Electronics Engineering (PCSIR) Karachi ...

*Fanconi anemia

Because of the failure of hematologic components to develop-white blood cells, red blood cells, and platelets-the body's ... Fanconi Anemia~treatment at eMedicine Page 29 in Moore, Pete (2007). The Debate About Genetic Engineering (Ethical Debates). ... First, the percentage of undifferentiated progenitor cells, blast cells, is always less than 20%, with considerably more ... "Role of Fanconi DNA repair pathway in neural stem cell homeostasis". Cell Cycle. 7 (13): 1911-5. doi:10.4161/cc.7.13.6235. PMID ...

*Neoplasm

... for B cell lesions) or T cell receptor gene (for T cell lesions). The demonstration of clonality is now considered to be ... International Journal of Engineering Science. 40 (12): 1297-316. doi:10.1016/S0020-7225(02)00014-9. Volokh KY (September 2006 ... These cells are presumed to be clonal - that is, they are derived from the same cell, and all carry the same genetic or ... A mutant or epigenetically altered stem cell may replace the other nearby stem cells by natural selection. Thus, a patch of ...

*YAP1

Cell. 122 (3): 421-34. doi:10.1016/j.cell.2005.06.007. PMID 16096061. Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC ... Journal of Tissue Engineering and Regenerative Medicine. 9 (5): 528-39. doi:10.1002/term.1957. PMID 25370612. Williamson KA, ... Huang J, Wu S, Barrera J, Matthews K, Pan D (August 2005). "The Hippo signaling pathway coordinately regulates cell ... Pan D (October 2010). "The hippo signaling pathway in development and cancer". Developmental Cell. 19 (4): 491-505. doi:10.1016 ...

*Neocentromere

"Chromosome engineering allows the efficient isolation of vertebrate neocentromeres". Developmental Cell. 24 (6): 635-648. doi: ... As neocentromeres are still a relatively new phenomenon in cell biology and genetics, it may be useful to keep in mind that ... Overexpression may be due to a loss of function in regulation of CENPA by proteolysis at inappropriate times of the cell cycle ... Perhaps reimaging the formation of neocentromeres from the perspective of the cell-cycle might reveal more about what type of ...

*Error correction code

Hamming codes are only suitable for more reliable single-level cell (SLC) NAND. Denser multi-level cell (MLC) NAND requires ... Glover, Neal; Dudley, Trent (1990). "Practical Error Correction Design For Engineers" (Revision 1.1, 2nd ed.). CO, USA: Cirrus ... "Error Correction Code in Single Level Cell NAND Flash memories" 16 February 2007 ...

*Carfilzomib

Inhibition of proteasome-mediated proteolysis results in a build-up of polyubiquinated proteins, which may cause cell cycle ... "Carfilzomib: From Discovery To Drug". Chemical & Engineering News. 2012-08-27. Retrieved 2013-07-30. "Onyx multiple myeloma ...
Karolinska Institute, Department of Cell and Molecular Biology, Stockholm,Sweden. Stem cell engineering of neural stem cells and differentiated neurons. Our studies focus on interactions between neural stem cells or neurons and their microenvironment. We report a conjugated polymer that can control growth factor presentation and thus rat neural stem cell state in vitro. In this context we are also exploring conjugated polymers for controlled small molecule release. Moreover, we are developing cholinergic neural differentiation, highly related to Alzheimers disease, from induced pluripotent stem cells in 2D and 3D hydrogel cultures. In hydrogel cultures we have observed upregulation of signaling pathways related to mechanotransduction and neuroprotection. We are currently establishing new iPS lines derived from Alzheimers patients and controls.. ...
Professional forum and technical support for engineers for Hydrogen and related fuel cell engineering. Includes problem solving collaboration tools.
Stem cells have shown huge potential for regenerative medicine, but there are several critical issues to be addressed to further improve therapeutic efficacy and regenerative potential of stem cell therapy and stem cell-based tissue engineering. Functional biomaterials can solve these the limitations of current stem cell therapy by promoting prolieration, specific lineage differentiation and improving in vivo survival and engraftment of transplanted stem cells. This thematic series in Biomaterials Research aims to provide collections of recent studies on developing biomaterials for improving stem cell-based regenerative medicine.. To submit a paper to this series, please visit the Biomaterials Research submission site. Make sure to choose the name of the series under the "Are you submitting to a thematic series?" question on the "Additional information" tab.. New articles in the series will appear here as they are published.. ...
A Mayo Clinic researcher and his collaborators have developed an online analytic tool that will speed up and enhance the process of re-engineering cells for biomedical investigation. CellNet is a free-use Internet platform ...
Lymphyblastic leukemia is a destructive, painful blood cancer that progresses quickly and can be fatal within months if left untreated. And while treatments such as chemotherapy are currently commonly used, many patients suffer relapse, lowering the diseases overall cure rate to between 30 and 40 percent.. But the genetic modification of T-lymphocytes is now emerging as a powerful approach to investigate T cell function. Alliance for Cancer Gene Therapy (ACGT) funded research grants for two investigators work in the area: that of Dr. Michel Sadelain, director of the Center for Cell Engineering & Gene Transfer and Gene Expression Laboratory at Memorial Sloan-Kettering Cancer Center, and Dr. Carl June, professor in Immunotherapy, Pathology and Laboratory Medicine at the University of Pennsylvanias Abramson Cancer Center.. Dr. Sadelains research on T cell engineering and artificial antigen was bolstered by a 2004-2007 ACGT research grant for a program that investigated the therapeutic potential ...
EBV transformed B cell lines derived from Japanese (HEV). ● We are providing B cell lines derived from healthy Japanese and the Japanese patients suffering from cancers etc. The cell lines derived from healthy individuals possess the precise information regarding HLA haplotypes and we are providing such information as well.. ● These cell lines are useful for genetic analyses, and thus we are providing these cell lines for researches including analyses of gene and genome. We provide this collection not only to domestic users in Japan but also to users in overseas, in addition not only to not-for-profit institutions but also to for-profit institutions.. ● Providing B cell lines were transformed by Epstein-Barr Virus.. ● In addition to the cell material itself, we are providing information about gender, age and habit of the individuals who have donated the source cells. When we possess the information of gene and/or genome, we provide them as well.. ● After the providing procedures ...
Genetically engineered cell therapies may bring hope to patients for whom standard treatments have been unsuccessful, according to two separate studies presented at the 2013 ASH Annual Meeting, in New Orleans, Louisiana.
Image:Bacon.jpg,thumb]] With the present interest in fuel cells - devices for directly generating electricity by chemically combining a fuel and oxygen - it is possible to forget that this technology goes back a long way. The first known example was the "gas battery," invented by William Robert Grove in the mid-19th century. But perhaps the most interesting figure to pioneer fuel cell technology in the early to mid-twentieth century was Francis Thomas Bacon. Francis Thomas Bacon was a forerunner in fuel cell technology. A descendant of the famous early modern English philosopher and champion of science Francis Bacon, F.T. Bacon was born in Billericay, UK, on 21 December 1904. Trained as an engineer at Trinity College, Cambridge, and employed by steam turbine builder C.A. Parsons in the 1930s, Bacon was fascinated by the ability of fuel cells to directly convert chemical into electrical energy. Although they were then considered a mere scientific curiosity, he became convinced of their ...
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
Medical Xpress is a web-based medical and health news service that features the most comprehensive coverage in the fields of neuroscience, cardiology, cancer, HIV/AIDS, psychology, psychiatry, dentistry, genetics, diseases and conditions, medications and more.
Promising Stem Cell Therapy Eliminates Metastatic Cells From the Brain - This shows tagged therapeutic stem cells (green) targeting breast cancer metastases (red) in the brain of a mouse model. Image credit: Khalid Shah/Massachusetts General Hospital #cancer #neurology #science
Emmanuel Tzanakakis is an associate professor in the Department of Chemical and Biological Engineering at Tufts University. He earned his Ph.D. in Chemical Engineering from the University of Minnesota. Tzanakakis did his postdoctoral training at the Stem Cell Institute of the University of Minnesota and at the Diabetes Center of the University of California, San Francisco. His laboratorys research interests are in the area of stem cell engineering, particularly for diabetes and heart disease applications. Implementing a combination of experiment- and computation-based approaches, the overarching goal of his research is the realization of the potential of stem cells in regenerative medicine.. ...
In the April 15th issue of G&D, Dr. Richard Flavell (Yale University) and colleagues identify the c-Cbl protein as a critical repressor of hematopoietic stem cell (HSC) self-renewal. In addition to establishing a key role for protein ubiquitylation in HSC development, this finding posits c-Cbl as a potential target in research into stem cell engineering as well as cell-based leukemia treatments.. Dr. Flavell describes the work as elucidating "a novel dimension in our understanding the self-renewal of Hematopoietic stem cells.". Like all stem cell populations, HSC reply upon asymmetric cell division to generate two different daughter cells: one future stem cell, and another cell that will further differentiate into a more specialized cell type. Thus, a balance is struck between the production of new cell types and the renewal of the stem cell pool. However, imbalances between HSC self-renewal and differentiation can lead to hematologic malignancies like leukemia.. Dr. Flavells group discovered ...
The National Institutes of Health (NIH) has awarded nearly $2 million to researchers at the Georgia Institute of Technology and Emory University to develop a new class of therapeutics for treating traumatic injuries and degenerative diseases. The five-year project focuses on developing biomaterials capable of capturing certain molecules from embryonic stem cells and delivering them to wound sites to enhance tissue regeneration in adults. By applying these unique molecules, clinicians may be able to harness the regenerative power of stem cells while avoiding concerns of tumor formation and immune system compatibility associated with most stem cell transplantation approaches. "Pre-clinical and clinical evidence strongly suggests that the biomolecules produced by stem cells significantly impact tissue regeneration independent of differentiation into functionally competent cells," said Todd McDevitt, director of the Stem Cell Engineering Center at Georgia Tech and an associate professor in the ...
Current research projects being undertaken at the Neuromuscular & Regenerative Medicine Unit at the School of Medical Sciences on unraveling signaling mechanisms for Adult Stem Cell Activation and Recruitment are presented. If you are interested in learning about the potential Honours Projects offered in 2011 on Stem Cell Engineering & Biology, please contact Dr Antonio Lee on [email protected] ...
CellectCell, a company spawned in labs at the Petit Institute for Bioengineering and Bioscience, is moving steadily toward commercial viability.. "We have recently begun pilot production for our initial product, the CellectCell MicroCassette™, and will have beta units in the next few months," says Rebecca Marshall, president and CEO of CellectCell. "We are very excited about the progress we have made toward commercializing this novel, label-free cell isolation technology.". The company is the brainchild of co-founders Andrés García and Todd McDevitt, who have deep roots in the Petit Institute and the Georgia Institute of Technology.. García, the Rae S. and Frank H. Neely Chair and Regents Professor in the Woodruff School of Mechanical Engineering, is a longtime faculty researcher at the Petit Institute. McDevitt, former Petit Institute researcher and director of the Stem Cell Engineering Center at Georgia Tech, is now a senior investigator at the Gladstone Institutes and professor in the ...
Nanocomposite hydrogels (NC gels) are nanomaterial-filled, hydrated, polymeric networks that exhibit higher elasticity and strength relative to traditionally made hydrogels. A range of natural and synthetic polymers are used to design nanocomposite network. By controlling the interactions between nanoparticles and polymer chains, a range of physical, chemical, and biological properties can be engineered. The combination of organic (polymer) and inorganic (clay) structure gives these hydrogels improved physical, chemical, electrical, biological, and swelling/de-swelling properties that cannot be achieved by either material alone. Inspired by flexible biological tissues, researchers incorporate carbon-based, polymeric, ceramic and/or metallic nanomaterials to give these hydrogels superior characteristics like optical properties and stimulus-sensitivity which can potentially be very helpful to medical (especially drug delivery and stem cell engineering) and mechanical fields. Nanocomposite ...
GEORGE CHURCH is professor of genetics at Harvard Medical School and director of the Personal Genome Project, which provides the worlds only open-access information on human genomic, environmental & trait data (GET). His 1984 Harvard PhD included the first methods for direct genome sequencing, molecular multiplexing and barcoding. These led to the first genome sequence (pathogen, Helicobacter pylori) in 1994. His innovations have contributed to nearly all "next generation" DNA sequencing methods and companies (CGI-BGI, Life, Illumina, Nanopore). This plus his labs work on chip-DNA-synthesis, gene editing and stem cell engineering resulted in founding additional application-based companies spanning fields of medical diagnostics (Knome/PierianDx, Alacris, AbVitro/Juno, Genos, Veritas Genetics) and synthetic biology / therapeutics (Joule, Gen9, Editas, Egenesis, enEvolv, WarpDrive). He has also pioneered new privacy, biosafety, ELSI, environmental and biosecurity policies. He is director of an ...
Upcoming Races within 25 miles of Chicago IL: Jan: Feb: Mar: Apr: May: Jun: Jul: Aug: Sep: Oct: Nov: Dec: Jingle Bell Run - Chicago. Diabetic Birthday Cake Dublin S Ketosis secondly the notion that insulin levels must be Diabetic cats also often have dilute urine unrelated to CKD and the resulting dehydration may also cause increased kidney values. Impact Factor: 3.035 Diabetes & Vascular Disease Research is the first For an alternate route to Diabetes and Vascular Disease Research Online Researches and trials on treatment of diabetes with stem cell engineering are in Type 1 Diabetes Read more articles on Type 1 Diabetes Mellitus CLINICAL PRACTICE UIDELINE: diabetes and jagged edge wounds. As a possible adjunct to insulin-like growth factor 1 and growth Interpretive Handbook. However they can sometimes have a more serious cause. Is drinking alcohol one of them? Can you drink safely and if so how? Learn about alcohol and diabetes. RELATED: Can You Exercise During Pregnancy? What if gestational ...
Michel Sadelain, MD, PhD, Director, Center for Cell Engineering and Gene Transfer and Gene Expression Laboratory, Stephen and Barbara Friedman Chair, Memorial Sloan Kettering Cancer Center (MSK), discusses chimeric antigen receptor (CAR) t-cell therapies.
The cell line engineering segment accounts for the largest share of the Global CRISPR/Cas9 genome editing market", says RNCOS. Genomic engineering in cell lines is a diversified tool for studying gene function, designing diseases models, biopharmaceutical research, drug discovery, and many other applications. For these, the Nuclease-based methods, particularly the CRISPR/Cas9 method, offer an efficient way of controlled gene insertion. A pseudoviral-packaged lentiviral sgRNA and Cas9 construct can be highly efficiently transduced and integrated into virtually any mammalian cells. For instance, CRISPR knockout cells generated using lentiviral CRISPR sgRNA expression vectors are being used to stably introduce and integrate an appropriate sgRNA and Cas9 nuclease.. The cell engineering application has generated the highest revenue for CRISPR market. One of the major factors attributing the growth are scalability of CRISPR/Cas9 in modifying the multiple sites within the mammalian genome providing a ...
LONDON, December 5, 2012 /PRNewswire/ --. - Market demands to reduce manufacturing costs require better Cell culture processes. According to further research conducted for the annual 2013 Cell Line Development & Engineering conference in Vienna next February, major developments in cell culture systems have given biotechs and pharmaceutical companies more flexibility to scale up cells to a high manufacturing quality. Cell engineering tools have enabled the production of high-performing cell lines and this has only been possible through improvements in cell culture media.. To best accommodate for these new developments, Informa Life Sciences have expanded the programme to cover the latest in cell line development strategies and improvements in cell culture systems. Speaker Alison Porter, Head of Cell Line Development in the Mammalian Cell Culture group at Fujifilm Diosynth Biotechnologies (FFDB) clarifies how With cell line construction on the critical path for first in human studies, it is ...
Mustang Dynamometer and Mustang Advanced Engineering have been designing and developing world class automotive testing systems for over 35 years. Mustang specializes in chassis dynamometers, engine dynamometers, transmission dynos and tow dynes. We also offer custom test cell engineering for any automotive testing needs.
Under the terms of the agreement, Vor obtains non-exclusive clinical and commercial use rights to MaxCytes Flow Electroporation® technology and ExPERT™ platform to develop up to five engineered cell therapies, including VOR33, Vors lead eHSC candidate, which is in development for acute myeloid leukemia (AML). In return, MaxCyte will receive undisclosed development and approval milestones and sales-based payments in addition to other licensing fees.. Vor will use MaxCytes cell engineering platform to deliver its gene editing machinery into hematopoietic stem cells to remove biologically redundant cell surface proteins that are also expressed on blood cancer cells. Once the eHSCs are transplanted into a cancer patient, these cells are effectively hidden from complementary targeted therapies that target the relevant protein, while diseased cells are left vulnerable to attack. Vors approach thereby could unleash the potential of targeted therapies by broadening the therapeutic window and ...
I am pleased to enter into this collaboration with Universal Cells for a novel cell therapy using their proprietary Universal Donor Cell technology based on gene editing by rAAV (recombinant Adeno-Associated Virus) and cell engineering of pluripotent stem cells," said Yoshitsugu Shitaka, Ph.D., president of AIRM. "This is definitely an important step forward in developing a potential new option as an innovative cell therapy to treat devastating diseases with high unmet medical needs.". While the research will be conducted jointly by AIRM and Universal Cells, Astellas will lead and fully fund the development program and will obtain worldwide rights for commercialization. In consideration for the collaboration and grant of rights, under the terms of the agreement, Universal Cells is eligible to receive up to $9 million in a combination of an upfront payment and research milestones. Universal Cells is also eligible to receive research funding and further clinical development and regulatory ...
The polymer scaffolds will be produced by Professors Steve Howdle and Kevin Shakesheff, experts in cells and chemistry engineering in the University of Nottingham. Professor Howdle clarifies: Building upon solid collaborations with cells engineering experts, this fresh grant will allow experts at Nottingham to consider their components nearer to the clinic. This could have got great benefits for sufferers, and also provide a significant price saving for health care authorities; but we have to verify and build upon our preliminary data first. A major area of the function at Nottingham calls for scaling up the supercritical liquid processing apparatus to develop larger and even more uniform batches of polymer scaffolds for assessment.A mechanism to induce senescence in particular nerve cells could delay or remove starting point of the diseases. Similarly, a disease like cancer, which thrives and spreads through unregulated replication of cancer cells, may be fought through induced senescence. This ...
Scientists and transplant clinicians at the Ansary Stem Cell Institute at Weill Cornell Medical College and the Center for Cell Engineering at Memorial Sloan Kettering Cancer Center have been awarded a $15.7 million, four-year research grant from the New York State Stem Cell Science Program (NYSTEM).. The scientists will translate their approach to manipulate hematopoietic stem cells to cure acquired and inherited blood disorders. For many patients with such blood diseases, including sickle cell disease, the only hope for a cure requires transplanting normal blood stem cells.. But in many instances suitable blood stem cells cannot be found or there are ...
Nanokicking Stem Cells Offers Cheaper And Easier Way To Grow New Bone Researchers in Scotland have developed a new method that coaxes stem cells into growing new bone by nanokicking them 1,000 times per second. They suggest the technology is cheaper and easier to implement than the current methods and opens the door to new ways of treating bone conditions like stress fractures, spinal traumas and osteoporosis. Matt Dalby from the Centre for Cell Engineering at the University of
Eukaryotic cell lines, including Chinese hamster ovary cells, yeast, and insect cells, are invaluable hosts for the production of many recombinant proteins. With the advent of genomic resources, one can now leverage genome-scale computational modeling of cellular pathways to rationally engineer eukaryotic host cells. Genome-scale models of metabolism include all known biochemical reactions occurring in a specific cell. By describing these mathematically and using tools such as flux balance analysis, the models can simulate cell physiology and provide targets for cell engineering that could lead to enhanced cell viability, titer, and productivity. Here we review examples in which metabolic models in eukaryotic cell cultures have been used to rationally select targets for genetic modification, improve cellular metabolic capabilities, design media supplementation, and interpret high-throughput omics data. As more comprehensive models of metabolism and other cellular processes are developed for ...
Tissue engineering. Laboratory technicians gloved hands hold petri dishes containing cultures of human tendon on smart bandages. Cut tendons lie on strips of synthetic bandage. The culture solution also contains human tendon cells. Smart bandage technology enables rapid regrowth and joining of damaged body tissues, like tendon or bone. Tiny grooves etched in the bandage direct the growth of tendon cells. Placed between broken ends of a tendon the bandage speeds healing and joining, after which the bandage biodegrades. This technology may provide templates for hip replace- ments & other cell engineering projects. Research conducted at the University of Glasgow, Scotland. - Stock Image M580/0106
Dr. Rivière received her Ph.D. in Cellular and Molecular Biology from the University of Paris. She initiated her graduate studies at the Institut Curie in Paris and completed her thesis in the laboratory of Dr. Mulligan at the Whitehead Institute in Cambridge, MA. During this time, she developed novel retroviral vectors for in vivo long-term expression of transgenes in hematopoietic cells using MFG/SFG-based retroviral vectors that are widely used in clinical studies for the treatment of genetic and acquired disorders.. She subsequently worked as a post-doctoral fellow in the laboratory of Dr. Littman at New York University, NY. Dr. Rivière joined the faculty of Memorial Sloan-Kettering Cancer Center in 1999. She is currently the Director of the Michael G. Harris Cell Therapy and Cell Engineering Facility where she investigates the genetic modification of hematopoietic cells to increase or retarget the immune response against tumors. ...
Host tropism is the infection specificity of certain pathogens to particular hosts and host tissues. This type of tropism explains why most pathogens are only capable of infecting a limited range of host organisms. Researchers can classify pathogenic organisms by the range of species and cell types that they exhibit host tropism for. For instance, pathogens that are able to infect a wide range of hosts and tissues are said to be amphotropic. Ecotropic pathogens, on the other hand, are only capable of infecting a narrow range of hosts and host tissue. Knowledge of a pathogens host specificity allows professionals in the research and medical industries to model pathogenesis and develop vaccines, medication, and preventative measures to fight against infection. Methods such as cell engineering, direct engineering and assisted evolution of host-adapted pathogens, and genome-wide genetic screens are currently being used by researchers to better understand the host range of a variety of different ...
European Cells & Materials Journal - Open and Free Access - The Official Research Journal of AOCMF, AOTrauma, European Orthopaedic Research Society (EORS), Swiss Society for Biomaterials (SSB) and Tissue & Cell Engineering Society (TCES)
Novel Cell Engineering Technologies with the Potential to Drive Discovery and Development of New Anti-Cancer Medicines -. - Structured Buy Out to Acquire Cell Design Labs for up to $567 Million -. EMERYVILLE, Calif., Dec. 07, 2017 (GLOBE NEWSWIRE) -- Cell Design Labs, Inc., a privately-held biotechnology company developing disruptive CAR-T and T cell receptor (TCR) therapies, announced today that Gilead Sciences (Nasdaq:GILD) has agreed to acquire Cell Design Labs in a structured buy out valued for up to $567 million, including the shares of Cell Design Labs held by Kite. According to Brian Atwood, President and CEO of Cell Design Labs, Inc., "Bringing our robust technology platforms under the Gilead umbrella, with its outstanding research and development capabilities and commitment to innovation, provides an exciting path forward for the development of the next generation of living therapies for patients with cancer.". "We have been working with Cell Design Labs for almost 18 months, and truly ...
By using MRI to detect magnetic probes of tiny iron oxide particles, an international research team for the first time has successfully tracked immune-stimulating cells implanted into cancer patients for treatment purposes. "In four of the eight patients, MRI revealed that the implanted cells werent where they needed to be to be effective for treatment," says Jeff Bulte, Ph.D., an associate professor of radiology at Hopkins Institute for Cell Engineering who developed methods to optimally label cells with the clinically approved iron oxide particles. This new application of the probes -- already clinically approved for MRI scanning of the liver -- could dramatically improve efforts to test and use cellular therapies such as vaccines to treat cancer or prevent its recurrence or stem cells to repair damaged organs, say the researchers. Bulte and a team of Dutch researchers used MRI and a magnetic probe approved by both European and U.S. agencies to locate therapeutic cells injected into eight ...
Most biopharmaceutical production platforms are based on fed-batch cell culture protocols, which can support high volumetric productivity while maintaining low operational complexity (1). The industry is interested in developing or refining high-titer cell culture processes to meet increasing market demands and reduce manufacturing costs (2). Although advancements in cell engineering have enabled development of high-performing recombinant cell lines (3,4,5,6), improvements in cell culture media and process parameter settings are required to realize the maximum production potentials of those cells (7,-8).…. ...
Yoshihiro Ohmiya (Principal Research Scientist), the Research Institute of Genome-based Biofactory (Director: Yoichi Kamagata) of the National Institute of Advanced Industrial Science and Technology (AIST) (President: Tamotsu Nomakuchi) and Chun Wu (Research Scientist), the Cell Dynamics Research Group, the Research Institute for Cell Engineering (Director: Hajime Ohgushi) of AIST, in collaboration with Michitaka Ozaki (Professor) of Graduate School of Medicine, Hokkaido University (President: Hiroshi Saeki), have developed a technique to locate cancer cells by synthesizing a near-infrared light-emitting protein and then conjugating it with a therapeutic antibody to produce a probe for cancer cells.. The near-infrared light-emitting protein was synthesized by introducing a near-infrared light-emitting organic fluorescent dye in the sugar chain of Cypridina luciferase. This fluorescent dye emits near-infrared light when energy transfer occurs in in vivo chemical reactions. Because near-infrared ...
December 22, 2005. NEW NEURONS TAKE BABY STEPS IN THE ADULT BRAIN. In experiments with mice, scientists from Johns Hopkins Institute for Cell Engineering have discovered the steps required to integrate new neurons into the brains existing operations.. For more than a century, scientists thought the adult brain could only lose nerve cells, not gain them, but in fact, new neurons do form during adulthood in all mammals, including humans, and become a working part of the adult brain in mice at the very least. In the first study to show how these "baby" neurons are integrated into the brains existing networks, the Johns Hopkins researchers show that a brain chemical called GABA readies baby neurons to make connections to old ones. The discovery is described in the Dec. 11 advance online section of Nature.. "GABA is important during fetal development, but most scientists thought it would have the same role it has with adult neurons, which is to inhibit the cells signals," says Hongjun Song, ...
Molecular Probes fluorescence reagents are among the most peer-referenced in all of life science research. Trusted product bands including Alexa Fluor, SYTOX and Click-iT empower scientists working in cell biology, genetic analysis, protein biology, and cell engineering to make the discoveries that advance our understanding today and catalyze the research goals of tomorrow.
Cells grow abundant when oxygen is available, and generally stop when it is scarce. Although this seems straightforward, no direct link ever has been established between the cellular machinery that senses oxygen and that which controls cell division. Now, in the June 10 issue of Molecular Cell, researchers at Johns Hopkins report that the MCM proteins, which promote cell division, also directly control the oxygen-sensing HIF-1 protein.. "Its always been a mystery why a vast excess of MCM proteins is present in cells, but now we have discovered at least one reason," says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine, director of the vascular program in Hopkins Institute for Cell Engineering and a member of the McKusick-Nathans Institute of Genetic Medicine. "Our data indicate that MCMs mediate crosstalk between the cell division machinery and proteins that help cells react to changes in their surroundings.". Since discovering HIF-1 in the 1990s, Semenzas team has ...
European Cells & Materials Journal - Open and Free Access - The Official Research Journal of AOCMF, AOTrauma, European Orthopaedic Research Society (EORS), Swiss Society for Biomaterials (SSB) and Tissue & Cell Engineering Society (TCES)
European Cells & Materials Conferences, official societies AOCMF, AOTrauma, European Orthopaedic Research Society (EORS), Swiss Society for Biomaterials (SSB) and Tissue & Cell Engineering Society (TCES)
The Broome Translational Medicine & Nanotherapeutic Lab integrates molecular biology, molecular chemistry, and molecular physics to bioengineer molecular imaging agents and bio-mimetic drug delivery vehicles.. Our research team combines expertise in areas of nano-material design, cell engineering, biomarker imaging, immunology, surgery, and oncology in order to develop multi-functional nanoparticles.. The overarching premise of our research is that it is possible to create multifunctional nano-therapeutics and post therapy monitoring tools with an emphasis on the development of a reliable nanotechnology-based solution for those organs where disease is characterized by low survival rates. ...
During the process, the eNOS plasmid loaded into the patients body using a EPCs nonviral delivery process called electroporation levitra generic levitraprix.net . A defined electrical field around the cells, the introduced plasmid eNOS allows generated. For this study, Northern with with MaxCyte, the expertise and a technical solution that, for a safe and effective cell engineering life-threatening diseaseaximized and minimized cell stress and damage to the cells allows features together. One day after the processing, the eNOS - modified cells via a catheter into via a catheter into the heart and pulmonary arteries of the patients from which they were harvested. We are delighted to be working with Northern Therapeutics to help move her PHACeT study agitated in clinical trials Our technology has been shown that extremely safe and effective, and it is capable of cell - based therapeutics, the reproducibility of high are present in quantities. Suitable for clinical and commercial use, said ...
Gregg Semenza, M.D., Ph.D., director of the vascular program at the Johns Hopkins Institute for Cell Engineering and a member of the McKusick-Nathans Institute of Genetic Medicine, is one of seven recipients of the 2010 Canada Gairdner Awards. Canadas only international science prizes, they are among the worlds most prestigious medical research awards.
Location: Birmingham, Alabama, United States. Jo o Paulo Lima Daher, MD, PhD, is a postdoctoral fellow at the Center for Neurodegeneration and Experimental Therapeutics and Department of Neurology at the University of Alabama at Birmingha. Dr. Daher received his MD from Fluminense Federal University in Brazil. He continued into a doctoral training jointly with the Johns Hopkins Institute for Cell Engineering, in the laboratories of Ted and Valina Dawson. His research focused in understanding the molecular mechanisms of Parkinsons disease, in particular the characterization of transgenic models of LRRK2 and alpha-synuclein, the two autosomal dominant causes of Parkinson s disease.. Dr. Daher joined the laboratory of Dr. Andrew West to further investigate the role of LRRK2 in neurodegeneration and neuroinflammatory responses associated to alpha-synuclein. Their ultimate goal is to fully describe the molecular and cellular mechanisms crucial to the development of novel pre-clinical models, and ...
We report the discovery and validation of a novel CHO cell engineering target (Serpinb1) that has significant effects in enhancing recombinant IgG productivity.
Our ECC with Intrexon grants us access to use their advanced transgene and cell engineering platforms for the development and production of lantibiotics, a class of peptide antibiotics that are naturally produced in Gram-positive bacteria and contain the characteristic polycyclic thioether amino acids lanthionine and methyllanthonine (collectively, the "Lantibiotics Program").. View ECC - Lantibiotics ». ...
Professor of Biochemistry at UTC, Karsten Haupt has been Director of the Enzyme and Cell Engineering (GEC) laboratory since 2012, reporting to the CNRS Institutes of Biological Sciences and Chemistry, plus the UTC and the University of Picardie Jules Verne (UPJV), Amiens.
Hello all. A colleague is interested in a supplier of solubile collagen-I which should be able to self assemble into fibrils. Cheers Bob; Cloudy Scotland -- Robert Hartley, Centre for Cell Engineering,Joseph Black Building University of Glasgow, Glasgow G12 8QQ Tel: ++44 (0)141 330 4756, Fax: 0141 330 3730 mailto:rh at mblab.gla.ac.uk Web : http://www.gla.ac.uk/Inter/CellEngineering ...
Sigma-Aldrich offers abstracts and full-text articles by [Daniel W Stuckey, Shawn D Hingtgen, Nihal Karakas, Benjamin E Rich, Khalid Shah].
This paper describes how we expressed the human LIF protein (rhLIF) in rice grain using a plant-based expression platform (ExpressTec) and demonstrated a 97% purity of the protein. Subsequent biochemical analysis of the rhLIF showed similar biochemical characteristics as compared to rhLIF derived from E. coli.
Innovations that initiate new technology cycles, i.e., radical innovations, bring tremendous value to Society and build for the companies that deploy them sustainable competitive advantages. However, large firms have typically been relatively inefficient at accessing from academia or technology start-ups such technological leaps. Indeed, most multiyear and multimillion dollar academia-industry partnerships have historically not resulted in any acceleration of the rate of deployment of game-changing innovations, which empirically proceeds in 25 year cycles, such as for example the expansion of the scope of the pharmaceutical industry from small molecules to biologics, or, projecting into the future, to siRNA or therapeutic stem cell technologies. Syndicated innovation venturing is a new strategic partnering concept described here that brings together actors from different economic segments in a non zero-sum game as a means to facilitate seed-funding, with the aim to de-risk technologies while reducing
Video articles in JoVE about nasal cavity include Nose, Sinuses, Oral Cavity and Pharynx Exam, Nasal Potential Difference to Quantify Trans-epithelial Ion Transport in Mice, Olfaction, The Respiratory System, Physiology of the Circulatory System, What is a Sensory System?, Compound Administration III, Cranial Nerves Exam I (I-VI), Physiology of the Circulatory System, Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis, Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor, Diagnostic Necropsy and Selected Tissue and Sample Collection in Rats and Mice, Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model, Ex Vivo Preparations of the Intact Vomeronasal Organ and Accessory Olfactory Bulb, The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response
In article ,791993754snz at pdchem.demon.co.uk,, Paul at pdchem.demon.co.uk (Paul Davis) writes: , In article ,3h18mt$jib at lyra.csx.cam.ac.uk, , seb1005 at mole.bio.cam.ac.uk Steven Brenner writes: , ,, medp4003 at leonis.nus.sg (Farid John Ghadessy) writes: ,, ,, ,Paul Davis (Paul at pdchem.demon.co.uk) wrote: ,, ,: Hello, ,, ,, ,: What do people feel is the current status of protein engineering ,, ,: and rational design based on analysis of structure and function ,, ,: of natural proteins? I would like to read about recent successes. ,, ,, ...There are many sorts of protein engineering and design... ,, All of these have had significant successes. Which do you want ,, to know more about? ,, , I am particularly interested to hear of examples where the technology , has been taken out of the lab and into successful medical or commercial , application. Can someone point me to illustrations of where the , rational modification of the natural forms has been made possible by , first looking at the ...
A third paper, published in JACC: Basic to Translational Science, demonstrated that a protein on cardiomyocytes called CD47 prevents macrophages from efficiently clearing heart cell debris. Shuang Zhang, a doctoral student in Thorps lab, was the first author of the study.. "We found that CD47 can act as a dont-eat-me, signal," Zhang said. "By blocking CD47 on dying heart cells, we were able to enhance clearance of harmful debris in the heart, and thus promote wound healing.". In future research, the Thorp laboratory intends to explore how findings from the three studies could be developed into novel therapies.. A large clinical trial, recently published in the New England Journal of Medicine, showed that an anti-inflammatory drug called canakinumab significantly improved cardiovascular outcomes in patients.. "The recent success of the CANTOS trial suggests that strategies that target inflammatory pathways in cardiovascular disease - such as ours - have potential to succeed in the clinic," ...
Cancer immunotherapy is an approach of treating cancer by harnessing the potential of bodys own immune system. After decades of initial disappointments in the area, the tide has finally changed with some recent successes in clinical trials.
Basic science advances in genomics have provided great promise for improving human health and reducing the burden of cancer in the United States. The recent successes in genome-wide association studies (GWAS) and related technologies in identifying genetic changes associated with a variety of common diseases have fueled the rapidly growing field of personalized medicine. The promise of personalized medicine is the ability to tailor the treatment or screening of individual patients based on their genotype. Many have highlighted the urgent need for multidisciplinary translational research that focuses on how to advance gene discoveries into effective clinical applications. Genetic screening for cancer susceptibility, one application of personalized medicine, has become a standard evidence-based practice in cancer prevention. Given the complexity of genetic information and the potential social and psychological sequellae, two in-person visits (e.g. pre-test and post-test counseling) with genetic ...
Im sure Jeter and company busted his chops pretty good about blowing the shut-out. Gary Sheffield had three hits and smacked the bejesus out of the ball on several occasions. He had three RBI and now has 101 on the season. Derek Jeter went hitless, but drew two walks. As badly as his walk totals have fallen off this year, Jeter has now earned a walk in seven straight games. Heaven Help Us. The Bombers remain three-and-a-half up on the Red Sox, who completed a three-game sweep of the Angels in Boston last night. The Sox are the hottest team in the majors right now, and while the culture in Boston might be changing, its certain that a good portion of Red Sox Nation is viewing their teams recent success with a healthy degree of skepticism. "They are just pumping us up to let us down once again," is what I imagine some of them are secretly thinking. You can hardly blame them, especially the older fans. What I think is sad is the Yankee-obsessed mentality expressed by a Sox fan in the Times ...
Cancer immune evasion is achieved through multiple layers of immune tolerance mechanisms including immune editing, recruitment of tolerogenic immune cells, and secretion of immunosuppressive cytokines. Recent success with immune checkpoint inhibitors in cancer immunotherapy suggests a dysfunctional immune synapse as a pivotal tolerogenic mechanism. Tumor cells express immune synapse proteins to suppress the immune system, which is often modulated by epigenetic mechanisms. When the methylation status of key immune synapse genes was interrogated, we observed disproportionately hypermethylated costimulatory genes and hypomethylation of immune checkpoint genes, which were negatively associated with functional T cell recruitment to the tumor microenvironment. Therefore, the methylation status of immune synapse genes reflects tumor immunogenicity and correlates with survival.. ...
Noreen Kamal and Mayank Goyal. The recent success of 5 endovascular randomized control trials has changed best practice guidelines1 to include EVT for AIS patients with an LVO with effect sizes in some studies as high as 25%. However, EVT is only offered in CSC, which makes access to this highly beneficial therapy difficult for patients who are outside the catchment area of a CSC. Should the EMT bypass a closer PSC to ensure that the patient has access to EVT sooner?. Here are some facts: (1) IV-tPA is not that effective in LVO; (2) time is brain: the faster we can achieve reperfusion, the higher is the likelihood of a good outcome; (3) endovascular treatment is safe and highly effective (number needed to treat of 2.5-7 in recent trials). Also it is quite likely that expertise, efficiency, and workflow are likely related to volume of patients treated and, as such, likely better at the CSC. Most CSCs have better 24/7 service not only for giving tPA but also for imaging, decision-making, and ...
This is mostly thanks to the recent success of two rappers that first made their name on mix tapes. The first is the most recently famous one - 50 Cents story has been rehashed and retold a thousand times. The second one is slightly less heralded. Camron released Purple Haze at the end of 2004 to great critical acclaim, and the record sold well, too. Camron is one member of the Diplomats, best known for releasing mix tape after mix tape on the streets of New York. Both got their starts in this underground, then got noticed, got big and got their money ...
Following the recent success of the smoking cessation sessions at RGU, we followed up with the two advisors from NHS Grampian who ran the sessions. As a whole the sessions were a great success. Two people followed the journey through to the quitting stage, which is really exciting, well done to them! Other people managed…
A shapeless-yet-sentient and malevolent mass of alien goo falls to earth with malevolent intentions. Is it the plot of Sonys upcoming science fiction thriller Life? Yes it is. But its also the origin story of Venom, the most iconic nemesis of Marvels Spider-Man. But Venom is a popular antihero in his own right and Sony looks ready to capitalize on this by giving the hulking hybrid of extraterrestrial entity and man a film of his own with a release date of October 5 2018.. Plot details are scarce and reports of directors and writers are contradictory, but it seems likely that Spideys black-clad foil is being set up to helm his own franchise and the recent success of Logan and Deadpool means an R-rating is a realistic possibility. Appropriate, given Venoms brutal nature.. Attempts have been made to get a Venom standalone film off the ground ever since the character made his cinematic debut in 2007s Spider-Man 3, with script writers such as Alex Kurzman, Robert Orci, and even Deadpool scribe ...
LA JOLLA - When Tiger Woods doesnt show up to defend a title, Camilo Villegas knows how to seize an opportunity.. Villegas, a flashy 27-year-old from Colombia, won his first two PGA Tour events last fall when injured Woods could not defend his titles at the BMW Championship and the Tour Championship, the last two FedEx Cup playoff events in 2008.. And now, with Woods unable to defend at the 2009 Buick Invitational, where he has won the past four years, Villegas took the first step toward another asterisk-worthy title by shooting a 9-under 63 at Torrey Pines to grab a three-shot lead after Thursdays first round. His closest pursuers are Davis Love III and Aaron Baddeley, who carded 6-unders 66s.. "Its very early in the week," Villegas said, trying to downplay his most recent success in the absence of the worlds top-ranked player, who has not returned to the tour since undergoing reconstructive knee surgery shortly after the U.S. Open last June. "I mean, Ive played one round.". But isnt it a ...
Based on our recent successes to establish MLCKs role in Ca2+-dependent signaling in mice, we propose similar approaches to unravel integrative signaling pathways in relation to MLCP and Ca2+-sensitization mechanisms.
The recent success authorities have had in taking down dangerous botnets has helped drive down the amount of spam flooding into business and consumer email accounts. In a report on security in 2011 released late last year, Cisco Systems found a "steep decline" in the volume of spam since August 2010, with the number of spam messages falling...
Brief Bio:. Amina received her PhD in Bioengineering from the University of California, Berkeley and UCSF, and a B.S. in Chemical Engineering from Rice University. Following her postdoctoral training in Biomedical Engineering at Johns Hopkins University, School of Medicine, she joined Rice University where she is an Assistant Professor in the Department of Bioengineering.. Her research interests are in neurovascular systems biology, cell engineering, and hypoxic response. Her labs research vision is to harness human cells natural behavior in order to understand and improve health. Specifically, Amina develops tightly coupled experimental-computational methods to identify the natural behaviors of brain cells (e.g., differentiation) and characterize the aberrant behaviors of cancer cells, and how they are constrained by molecular signaling as cells develop into functional tissue. She has authored or coauthored 30 publications; cofounded the tech startup DiBS; and served as scientific lead of a ...
Biobutanol is a sustainable green biofuel that can substitute for gasoline. Carbon flux has been redistributed in Clostridium tyrobutyricum via metabolic cell engineering to produce biobutanol. However, the lack of reducing power hampered the further improvement of butanol production. The objective of this study was to improve butanol production by rebalancing redox. Firstly, a metabolically-engineered mutant CTC-fdh-adhE2 was constructed by introducing heterologous formate dehydrogenase (fdh) and bifunctional aldehyde/alcohol dehydrogenase (adhE2) simultaneously into wild-type C. tyrobutyricum. The mutant evaluation indicated that the fdh-catalyzed NADH-producing pathway improved butanol titer by 2.15-fold in the serum bottle and 2.72-fold in the bioreactor. Secondly, the medium supplements that could shift metabolic flux to improve the production of butyrate or butanol were identified, including vanadate, acetamide, sodium formate, vitamin B12 and methyl viologen hydrate. Finally, the free-cell
Stem cell-based therapy has been proposed as a potential means of treatment for a variety of brain disorders. Because ethical and technical issues have so far limited the clinical translation of research using embryonic/fetal cells and neural tissue, respectively, the search for alternative sources of therapeutic stem cells remains ongoing. Here, we report that upon transplantation into mice with chemically induced hippocampal lesions, human olfactory ecto-mesenchymal stem cells (OE-MSCs) - adult stem cells from human nasal olfactory lamina propria - migrated toward the sites of neural damage, where they differentiated into neurons. Additionally, transplanted OE-MSCs stimulated endogenous neurogenesis, restored synaptic transmission, and enhanced long-term potentiation. Mice that received transplanted OE-MSCs exhibited restoration of learning and memory on behavioral tests compared with lesioned, nontransplanted control mice. Similar results were obtained when OE-MSCs were injected into the ...
The rise of digital pathology and with it the challenges of histopathology analysis have been the focus of a worldwide effort in the overall fight against cancer. In parallel, the recent success of automated decision-making, machine learning, and specifically deep learning, have revolutionised the basis of research as we know today. In this thesis, we tackle the prediction of treatment response in triple-negative breast cancer patients with two different approaches that reach similar outcomes. The first line of approach, based on the recent success of computer vision, extracts learned features from the data in order to perform classification. The second line of approach forces the information flow to pass through nuclei segmentation. In particular, it allows the incorporation of high-resolution information on to a lower resolution overview. Yet while this approach is more appealing as it is based on the analysis and quantification of a precise biological element, nuclei segmentation is troublesome.
Artificial Intelligence (AI), despite its recent successes on several fronts, has still serious limitations when it comes to the problems related to the deep understanding the world. Law is an area, where mostly shallow AI probabilistic solutions are not useful. As a consequence, many of the standard routines, where humans are performing well, are still not solvable with the current AI techniques and systems. In the presentation we will touch what are the limits of the current AI and what is the reason for them. Recent successes and popularity of AI is often raising expectations what technology could do - in reality, many of the
Finally, how are different countries addressing secondary prevention?. CG: I think systems that tie reimbursement to outcomes are being implemented in many countries around the world. Examples include the United Kingdom where primary care is incentivised so that patients blood pressure, lipids levels and diabetes are being managed; simple critically important risk factors have been much better managed following the National Health Service focus on tying reimbursement to these activities. Also, in some of the Scandinavian countries, such as Denmark and Sweden, the governments have put an enormous focus on having high quality registries, with the idea of improving quality of care. As a result, the care patients receive following an acute coronary syndrome is some of the best in the world.. The success of these different approaches show that we can learn from what other countries have found to be successful in improving secondary prevention.. GB-W: A key question is, how does the patient run ...
Ramush Haradinaj (file photo) UN Secretary-General Kofi Annan this week praised Ramush Haradinaj for stepping down as prime minister of Kosovo and surrendering to the UN war crimes tribunal in The ...
Cancer is believed to be driven by genetic mutations. However, mouse models and human patients with cancer-predisposing germ line mutations show that only a small fraction of their cells become malignant, suggesting mutations themselves are not sufficient to cause transformation and additional determinants must exist. There are two prevailing, non-exclusive models to account for the additional determinants. One is that full transformation requires accumulation of multiple genetic mutations, which posits transformation occurs only when all mutations have been acquired. The recent success in reprogramming malignant cells into pluripotent stem cells indicates that normal cells of essentially all lineages can exist in the presence of replete cancer mutations. The second model postulates that mutations in rare stem cells initiate malignancy. Advancement in sequencing technology has led to the detection of cancer mutations in the hematopoietic stem cells (HSCs) of healthy individuals. The prevalence ...
Jadhav, V., Hackl, M., Druz, A., Shridhar, S., Chung, C-Y., Heffner, K.M., Kreil, D.P., Betenbaugh, M., Joseph Shiloach, J., Niall Barron, N., Grillari, J., Borth, N. (2013) CHO microRNA engineering is growing up: Recent successes and future challenges. Biotechn. Advances, 31:8:1501-1513. Jadhav, V., Hackl, M., Klanert, G., Hernandez Bort, J.A., Kunert, R., Borth, N., Grillari, J. (2014) Stable overexpression of miR-17 enhances recombinant protein production of CHO cells. J Biotechn 175, 38-44. Klug, L., Tarazona, P., Gruber, C., Grillitsch, K., Gasser, B., Trötzmüller, M., Köfeler, H., Leitner, E., Feussner, I., Mattanovich, D., Altmann, F., Daum, G., (2013) The lipidome and proteome of microsomes from the methylotrophic yeast Pichia pastoris, Biochimica et Biophysica Acta, 215-226. Klavins, K., Neubauer, S., Al Chalabi, A., Sonntag, D., Haberhauer-Troyer, C., Russmayer, H., Sauer, M., Mattanovich, D., Hann, S., Koellensperger, G. (2013) Interlaboratory comparison for quantitative primary ...
The Annual Meeting has a traditional emphasis on the biology of HIV/AIDS, including the perspectives of basic science, clinical science and new treatment and prevention approaches. In 2010 we are expanding the emphasis on vaccines to recognize the importance of this area and learn how recent successes may guide new directions in HIV vaccine research and development. International vaccine experts will describe vaccine immunogens that are moving through human clinical trials, efforts to define immune correlates of protection, possible applications for therapeutic vaccination and a range of vaccine delivery strategies that are bringing us closer, everyday, to effective protection from HIV disease. Recognizing the important parallels of HIV and cancer, we include discussions of cancer-causing viruses, new cancer vaccines and fundamental research in cancer. In developed countries, cancer is emerging as the leading cause of death for persons with HIV, and these fields are inexorably linked in terms of ...
High-risk neuroblastoma remains a significant cause of cancer-related death in children. Although we have seen dramatic improvement in the treatment of both solid and liquid pediatric tumors, survival rates for both have plateaued since the mid-1990s (30). Patients with relapsed neuroblastoma are largely incurable, although temporary control of disease can be achieved for some patients. Thus, a new therapeutic paradigm is needed to improve survival. Not until recently has engineered T-cell therapy begun to meet its potential. Integration of the powerful cytotoxicity, significant in vivo proliferation, and surveillance mechanisms of memory T cells with the antigen specificity endowed by CARs has created a platform for the success of cell therapy. As we have suggested, the recent successes of CAR therapy (8-10) may primarily be attributed to improved cell-manufacturing processes that generate T cells armed with rapid and potent in vivo effector and proliferative capacity (31).. Previous reports ...
Molecular pathological epidemiology (MPE) is a transdisciplinary and relatively new scientific discipline that integrates theory, methods, and resources from epidemiology, pathology, biostatistics, bioinformatics, and computational biology. The underlying objective of MPE research is to better understand the etiology and progression of complex and heterogeneous human diseases with the goal of informing prevention and treatment efforts in population health and clinical medicine. Although MPE research has been commonly applied to investigating breast, lung, and colorectal cancers, its methodology can be used to study most diseases. Recent successes in MPE studies include: (1) the development of new statistical methods to address etiologic heterogeneity; (2) the enhancement of causal inference; (3) the identification of previously unknown exposure-subtype disease associations; and (4) better understanding of the role of lifestyle/behavioral factors on modifying prognosis according to disease subtype.
This book is an overview of current progress in drug design, applications of drug design, and new methodologies. It focuses on energetics of drug interactions with solvents and biomolecules, applications of traditional drug design methods, and related evolutionary algorithms. The volume concludes with a survey of recent successes and failures and describes outlooks for the future.
January, the beginning of a new year, seems like a great time to think about success. What does success mean to you? What successes have you had in the past? What goals/successes lie ahead for you? We, at Mind Matters, find success when our clients find success. Id like to share two examples of recent successes here at Mind Matters:. One is from a mom about her son who has been diagnosed with Autism and ADHD. He has been taking our Fast ForWord class for about two weeks. Fast ForWord is a computer-based, scientifically proven program developed by Scientific Learning (www.scilearn.com). The program is a reading and language intervention program that improves auditory/visual processing skills which leads to academic achievement, while building self-confidence along the way. We offer Fast ForWord here at the Clinic, at home with professional guidance, and at a Sonora location. Please call the office at 728-2184 for more information and assessment. Bob [not his real name] is also taking our ...
Permeability of the limiting membrane to K+is a feature of all cells, prokaryotic and eukaryotic. It would seem that in some fundamental way it is important to cells that the membrane separating inside from out be permeable to K+. Especially in the case of plants, one is able to point to specific physiological processes assisted by this permeability, such as nutrient uptake and osmoregulation (Maathuis et al., 1997), but it is possible that even more fundamental or vital reasons for the ubiquity of K+ permeability will be revealed in the future. Interdisciplinary studies that combine genetics and (electro) physiology may provide the next level of understanding. The recent success of approaches in which a channel protein is ablated through genetic mutation and the physiological consequences assessed with physiological assays gives reason to be optimistic (Gaymard et al., 1998b; Hirsch et al., 1998; Geleen et al., 2000; Sunkar et al., 2000).. A combination of "knockout" mutations and ...
Waltham, MA (PRWEB) August 22, 2017 -- Elmwood Park, a suburb of Chicago has had recent success in reducing crime in rental properties specifically from the
Bohemia, NY (PRWEB) March 05, 2013 -- On March 5, 2013, fitness expert and kettlebells advocate Lorna Kleidman responds to the recent success of Downsize
Since the inception of artificial intelligence, games have benchmarked algorithmic advances. Recent success in classic board games such as Chess and Go have left space for video games that pose...
Gansevoort Las Vegas will be the fourth installment of the luxury hospitality brand following the recent success of Gansevoort Park Avenue in New York. Following a $185 million renovation, Gansevoorts iconic style will completely reimagine the hotel experience in Las Vegas, creating the only intimate property among the Strips towering skyscrapers. Gansevoort Las Vegas will feature 188 Parisian apartment-style guest rooms including 19 suites, designed by Tandem Las Vegas. An intimate lobby space will welcome guests upon arrival, with a redesigned lobby bar, ultra-lounge, retail outlets, and 40,000 square-foot casino providing a unique upscale energy. A destination restaurant overlooking the Strip will round out the guest experience.. "We are confident that the Gansevoort Las Vegas will be unlike anything that exists in Las Vegas today," said Michael Achenbaum, founder and president, Gansevoort Hotel Group.. Gansevoort Las Vegas will also feature another first for Las Vegas - the creation of ...
Carbohydrates, through the process of glycoconjugation, play a vital role in a number of important eukaryotic cell signalling processes. Professor Valentin Wittmann and his team at the University of…
How to Make a Model Cell. A cell model is a 3-dimensional model showing the parts of a plant or an animal cell. You can make a model cell with things from around your house, or you can buy a few simple items to create a fun, educational...
Mucosal-associated invariant T (MAIT) cells, the most abundant T cell subset in humans, are increasingly being recognized for their importance in microbial immunity. MAIT cells accumulate in almost every mucosal tissue examined, including the lung, liver, and intestinal tract, where they can be activated through T cell receptor (TCR) triggering as well as cytokine stimulation in response to a host of microbial products. In this review, we specifically discuss MAIT cell responses to bacterial and fungal infections, with a focus on responses that are both MR1-dependent and -independent, the evidence for diversity in MAIT TCR usage in response to discrete microbial products, protective immunity induced by MAIT cells, and MAIT cell antimicrobial functions in the context of these infections ...
The recent success of cancer immunotherapy approaches, namely immune checkpoint blockade and adoptive T cell transfer approaches, have instilled new hope on the use of the immune system to fight cancer. The Humanitas Cancer Center is currently testing many novel anti-cancer biological therapies in the context of Phase I, II and III clinical trials that not only block cancer cells but also boost the immune system of the host. The LTI profile the immune system of such patients in the course of therapy, disease progression and cure. We aim to identify immune correlates of response to therapy as well as new biological effects at the level of lymphocytes subpopulations.. ...
Haploidy is a useful feature for the study of gene function because disruption of one allele in haploid cells, which contain only a single set of chromosomes, can cause loss-of-function phenotypes. Recent success in generating haploid embryonic stem (ES) cells from several mammalian species, including human, provides a new platform for simple genetic manipulation of the mammalian genome. The genome-editing potential of the CRISPR/Cas system is enhanced by the use of haploid ES cells. For example, CRISPR/Cas has been used for high-efficiency generation of multiple knockouts and knockins in haploid ES cells, with potential application in genome-wide screening ...
As the global music industry turns its attention to Africa, Nigeria’s Burna Boy is quickly becoming its biggest recent success.
While the Clippers have had the most recent success in the regular season and are considered a championship contender this season, they have not made it past the second round of the playoffs in their franchise history despite having Griffin and Chris Paul for the last three seasons. There will continue to be discussions if this trend continues, but Los Angeles will remain a Lakers town and many of the current Clippers players have acknowledged that despite their winning ways in the regular season. While there are low expectations for the Lakers, the return of a healthy Kobe Bryant should make the team more competitive as they look to rebound from their worst season in franchise history. [divide]. Kobe Bryants Big Drop In Sports Illustrateds 2014 NBA Player Rankings. ...
Editorial Board. "…It is no coincidence that the countries now affected by Ebola are some of the worst governed in the world. Public health is not a priority there, which is why it took months to notice what was happening. … One lesson learned from recent successes against AIDS, malaria, and TB is that victory comes only when the whole infrastructure of health, including the active involvement of local people, is promoted. As places get richer (as many African nations now are), more money for public health becomes available. With luck, then, outbreaks such as the current one will get rarer in the future…" (8/16).. New York Times: A Painfully Slow Ebola ...
Chelsea midfielder Ruben Loftus-Cheek believes the lack of ego in the Chelsea changing room is a reason for their recent success under manager Antonio Conte.
Background T cells engineered to express chimeric antigen receptors (CARs) have established efficacy in the treatment of B-cell malignancies, but their relevance in solid tumors remains undefined....
BACKGROUND: Corticosteroids often induce steroid psychosis, a collection of heterogeneous syndromes with different pathophysiologic mechanisms. To date, no study has focused specifically on recurrent corticosteroid-induced mood disorders and consider
This patent search tool allows you not only to search the PCT database of about 2 million International Applications but also the worldwide patent collections. This search facility features: flexible search syntax; automatic word stemming and relevance ranking; as well as graphical results.
This trial is conducted in the United States of America (USA). The aim of this trial is to investigate the safety, tolerability, efficacy and pharmacokinetics (the rate at which the trial drug is eliminated from the body) of NNC 0070-0002-0453 in overweight/obese, but otherwise healthy male and female volunteers. Selected subjects will continue in a follow-up period of up to 5 years ...
Transgenic mouse models that overexpress APP develop senile plaques over time that resemble those found in human Alzheimers disease. These animals are a valuable tool toward understanding the physiology and pathology of senile plaques in living tissue and are ideal for evaluating therapeutics aimed at clearance of amyloid-β deposits in the brain. With the recent success using immunotherapy for prevention of amyloid-β deposits in these animals (Schenk et al., 1999; Bard et al., 2000), as well as clearance of existing plaques (Bacskai et al., 2001), this treatment seems very promising. Recent reports have also indicated that immunotherapy may have positive effects on behavioral deficits exhibited in transgenic mouse models (Janus et al., 2000; Morgan et al., 2000). These findings are important for predicting whether anti-amyloid therapies will prove beneficial not just in arresting deposition of amyloid-β but also in prevention of the associated dementia. Microglial cells were implicated in ...
London: Scientists have identified a key gene used by poppies to make morphine, paving the way for better methods of producing the medically important drug, potentially without the need for cultivating poppy fields.. The latest finding follows recent success in engineering brewer`s yeast to synthesise opiates such as morphine and codeine from a common sugar, boosting the prospect of "home-brew" drug supply.. But whether making morphine in bubbling vats of yeast will be commercially viable - either for drug companies or criminal gangs - is far from certain, since poppies are very efficient natural factories.. "Poppies are not going to be displaced overnight by any stretch of the imagination," said Ian Graham, a professor at the University of York, who worked on the latest gene discovery.. While extracting opiates from genetically engineered yeast is now a real possibility, he sees more immediate benefits from applying the latest knowledge to developing better poppy plants.. "Having our hands on ...
... antigen expressed by neuroblastoma tumor cells and treated patients with this disease. extended, low-level persistence in patients, and such persistence was associated with longer survival. This study is registered at www.clinialtrials.gov as #"type":"clinical-trial","attrs":"text":"NCT00085930″,"term_id":"NCT00085930″NCT00085930. Introduction Adoptively transferred T cells Rabbit Polyclonal to ZADH2 can recognize tumor-associated antigens presented in association with MHC molecules on the cell surface. However, many cancer cells and solid tumors have defects in antigen processing and presentation,1,2 including down-regulation of and/or failure to express MHC molecules.3,4 Introducing tumor-specific chimeric antigen receptors (CARs) into adoptively transferred T cells allows them to recognize tumor-associated antigens in an Resminostat hydrochloride manufacture MHC-independent manner while retaining their ...
Title:Chimeric Antigen Receptor T Cell Based Immunotherapy for Cancer. VOLUME: 13 ISSUE: 5. Author(s):Feng Li, Tengfei Zhang, Ling Cao and Yi Zhang*. Affiliation:Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan. Keywords:Cancer immunotherapy, CAR T cells, hematologic malignancies, solid tumor, cancer cells, leukemia.. Abstract:Cancer immunotherapy, a new weapon against cancers by harnessing the patients own immune system, potentiates an extended remission and possibly a cure for cancer. T cells genetically engineered with chimeric antigen receptor (CAR) vectors can specifically target the surface antigen of cancer cells and kill them in an MHC-independent manner. CD19 is extensively ...
Former U.S. President and Carter Center Founder Jimmy Carter announced today that only three endemic countries remain in the fight against Guinea worm disease, poised to be only the second disease in history-after smallpox-to be eradicated.. "Guinea worm disease is fewer than 1,800 cases away from becoming only the second disease in history to be wiped from Earth," said President Carter, who was joined by former Nigeria Head of State General Yakubu Gowon, Nigeria Federal Minister of Health Prof. Onyebuchi Chuwku, Nigerien Counselor Boubacar Moussa Rilla, and other dignitaries from around the world for the The Carter Center Awards Ceremony for Guinea Worm Eradication to honor Nigeria and Niger.. "Nigeria and Nigers recent success halting transmission of this ancient and horrible affliction provides yet another vivid reminder of how people in even the most marginalized circumstances can thrive when given the tools and knowledge to help themselves," President Carter said.. ...
GENEVA, Feb. 8, 2014 /PRNewswire-USNewswire/ -- Buoyed by progress made in two of three countries where polio has never been stopped and Indias recent success marking three years polio-free, the Lawrence Ellison Foundation announced a planned gift of US$100 million over five years to support global polio eradication. Roughly $20 million of that contribution was delivered in 2013. The donation will help fund the Global Polio Eradication Initiatives (GPEI) $5.5 billion six-year plan to eradicate polio. The Lawrence Ellison Foundation brings the number of major philanthropies to 10 that have pledged a total of $535 million, in addition to the $1.8 billion commitment announced by Bill Gates, co-chair of the Bill & Melinda Gates Foundation, during 2013-2018 to support the GPEI strategy. At the Global Vaccine Summit held in Abu Dhabi last April, more than 35 government and private donors, including the Gates Foundation, pledged $4 billion to support the strategy, recognizing the unique opportunity ...
The use of chimeric antigen receptor (CAR)Cmodified T cells as a therapy for hematologic malignancies and solid tumors is becoming even more widespread. modified by giving epigenetic modulators that upregulated focus on manifestation and improved CAR T-cell strength. Intro Capital t cells altered to communicate tumor-directed chimeric antigen receptors (Vehicles) possess demonstrated medical effectiveness in dealing with both hematological malignancies and solid tumors.1,2,3,4,5,6 It is likely, nevertheless, that the the majority of effective make use of of CAR-modified T cells will need extra design to allow them to overcome growth defense get away systems. One of the most essential of these get away strategies is usually focus on antigen modulation under picky pressure.7 This trend has been reported as a trigger of failing in both preclinical and medical research using adoptively moved T cells with sole antigen 1431697-90-3 manufacture specificity to deal with heterogeneous tumors,7,8,9 and ...

Biomaterials for Stem Cell EngineeringBiomaterials for Stem Cell Engineering

... Edited by: Seung-Woo Cho, Yonsei University, Korea. ... to further improve therapeutic efficacy and regenerative potential of stem cell therapy and stem cell-based tissue engineering ... Stem cells have shown huge potential for regenerative medicine, but there are several critical issues to be addressed ... Functional biomaterials can solve these the limitations of current stem cell therapy by promoting prolieration, specific ...
more infohttps://www.biomedcentral.com/collections/bsce

Hydrogen and related fuel cell engineering Forum - Eng-TipsHydrogen and related fuel cell engineering Forum - Eng-Tips

Professional forum and technical support for engineers for Hydrogen and related fuel cell engineering. Includes problem solving ... Hydrogen and related fuel cell engineering. (2204 members). forum804 - Professional forum and technical support for engineers ... Cities are ceaseless engines of engineering activity. It’s likely that while you were on your way to work, you encountered a ... In late 2017, ENGINEERING.com surveyed 205 product development professionals about their plans to include Internet of Things ( ...
more infohttp://www.eng-tips.com/threadminder.cfm?pid=804&page=3

New tool aids stem cell engineering for medical researchNew tool aids stem cell engineering for medical research

... and his collaborators have developed an online analytic tool that will speed up and enhance the process of re-engineering cells ... Details of CellNet and its application to stem cell engineering are described in two back-to-back papers in the journal Cell. ... CellNet uses 21 cell types and tissues and data from 56 published human and mouse engineering studies as a basis for analyzing ... "CellNet will indicate how closely an engineered cell resembles the real counterpart and even suggests ways to adjust the ...
more infohttps://phys.org/news/2014-08-tool-aids-stem-cell-medical.html

Anna Herland: Stem cell engineering of neural stem cells and differentiated neurons</span>Anna Herland: "Stem cell engineering of neural stem cells and differentiated neurons"</span>

Stem cell engineering of neural stem cells and differentiated neurons. Our studies focus on interactions between neural stem ... Anna Herland: "Stem cell engineering of neural stem cells and differentiated neurons" ... Anna Herland: "Stem cell engineering of neural stem cells and differentiated neurons" ... Anna Herland: "Stem cell engineering of neural stem cells and differentiated neurons" ...
more infohttp://www.frias.uni-freiburg.de/de/das-institut/archiv-frias/school-of-softmatter/veranstaltungen/anna-herland-stem-cell-engineering-of-neural-stem-cells-and-differentiated-neurons

Induction of Immunity to Prostate Cancer Antigens: Results of a Clinical Trial of Vaccination with Irradiated Autologous...Induction of Immunity to Prostate Cancer Antigens: Results of a Clinical Trial of Vaccination with Irradiated Autologous...

Results of a Clinical Trial of Vaccination with Irradiated Autologous Prostate Tumor Cells Engineered to Secrete Granulocyte- ... LNCaP PCA cells (43) , PC-3 PCA cells (44) , DU 145 PCA cells (45) , A549 lung carcinoma cells (46) , LS-174T colon carcinoma ... B, Lane 1, PC-3 PCA cells; Lane 2, LNCaP PCA cells; Lane 3, A549 lung carcinoma cells; Lane 4, LS-174T colon carcinoma cells; ... cells (47) , KLE endometrial carcinoma cells (48) , Jurkat T-cell leukemia cells (49) , and MDA-MB-435 breast carcinoma cells ( ...
more infohttp://cancerres.aacrjournals.org/content/59/20/5160

Stem Cell Engineering | SpringerLinkStem Cell Engineering | SpringerLink

The potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized ... bioreactors cell expansion differentiation drug discovery embryonic stem cell growth stem cell growth ... stem cells and drug discovery, screening platforms. Stem Cell Engineering offers valuable background and reference for both the ... Engineering the Stem Cell Niche and the Differentiative Micro- and Macroenvironment: Technologies and Tools for Applying ...
more infohttps://link.springer.com/book/10.1007%2F978-3-642-11865-4

Magnetic Cell-Patterning for Tissue Engineering | SpringerLinkMagnetic Cell-Patterning for Tissue Engineering | SpringerLink

We report a magnetic cell-patterning technique to control arrangements of target cells for the fabrication of three-dimensional ... Steel Plate Human Umbilical Vein Endothelial Cell C2C12 Cell Cell Sheet Cell Patterning These keywords were added by machine ... Wilson, W.,C., Jr., and Boland, T. (2003) Cell and organ printing 1: protein and cell printers. Anat. Rec. A Discov. Mol. Cell ... was formed on a monolayer of cells or a magnetic tissue-engineered cell sheet constructed by accumulating MCL-labeled cells ...
more infohttps://link.springer.com/chapter/10.1007/978-90-481-3892-0_27

Laboratory for Cell & Tissue EngineeringLaboratory for Cell & Tissue Engineering

Laboratory for Cell .... Research Lab Laboratory for Cell & Tissue Engineering The Laboratory for Cell & Tissue Engineering ... The Laboratory for Cell & Tissue Engineering facilitates research on the culturing and engineering of the patients own - or ... The Laboratory for Cell & Tissue Engineering is an ultramodern laboratory. The research that takes places here extends across ... Facilities include a fully equipped cell culture room ideal for elaborate experimental tissue engineering. Tissues are tested ...
more infohttps://www.tue.nl/en/research/research-labs/laboratory-for-cell-tissue-engineering/

Cell Engineering and Regeneration | Jeffrey M. Gimble | SpringerCell Engineering and Regeneration | Jeffrey M. Gimble | Springer

... including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. ... Cell Engineering and Regeneration. Editors: Gimble, J.M., Marolt, D., Oreffo, R., Redl, H., Wolbank, S. (Eds.) ... as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and ... new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules. ...
more infohttp://www.springer.com/jp/book/9783319088303

Stem cell engineering and regenerative medicineStem cell engineering and regenerative medicine

... * Content type: Research. Improved expansion of equine cord blood derived ... Equine mesenchymal stromal cells (MSCs) are increasingly investigated for their clinical therapeutic utility. Such cell-based ... Human pluripotent stem cell differentiation to functional pancreatic cells for diabetes therapies: Innovations, challenges and ... Comprised of parenchymal cells, stromal cells, structural extracellular matrix proteins, and sign... ...
more infohttps://www.biomedcentral.com/collections/stemcells

AIMS Cell and Tissue Engineering | Directory of Open Access JournalsAIMS Cell and Tissue Engineering | Directory of Open Access Journals

Information about the open-access journal AIMS Cell and Tissue Engineering in DOAJ. DOAJ is an online directory that indexes ...
more infohttps://doaj.org/toc/2574-0105

TMJ: Stem Cell Biology And Engineering Toward Clinical Translation - RedorbitTMJ: Stem Cell Biology And Engineering Toward Clinical Translation - Redorbit

Recently, stem/progenitor cells have been identified in TMJ disc and condyle, with potential origin from neural crest cells in ... Stem Cell Biology and Engineering toward Clinical Translation" will provide a rare forum for multidisciplinary discussion of ... Putative TMJ stem/progenitor cells are subjected to local, hormonal and other systemic factors in homeostasis in multiple ... the biology, engineering and clinical translation of fundamental discoveries towards novel clinical therapy. The symposium is ...
more infohttp://www.redorbit.com/news/health/1112498359/tmj-stem-cell-biology-and-engineering-toward-clinical-translation/

Insect Cell Culture Engineering: 1st Edition (Paperback) - RoutledgeInsect Cell Culture Engineering: 1st Edition (Paperback) - Routledge

... fundamental notions of virology and animal cell cultivation, this practical reference examines the development of insect cell ... Resolving on-the-job problems such as sparging cell damage and reduced infectivity cells, Insect Cell Culture Engineering: ... Insect Cell Culture Engineering is designed as a reference for biochemical and bioprocess engineers, bioprocess technologists, ... foreign gene expression in insect cells, Donald L. Jarvis; the future of insect cell culture engineering, Spiros N. Agathos. ...
more infohttps://www.routledge.com/Insect-Cell-Culture-Engineering/Goosen/p/book/9780367402419

Cell SignalingCell Signaling

Limitations in Single-Cell Analysis Must Be Addressed with Innovation. Cannabinoids Liquid Gold: Engineers Strike Oil Making ... Cell Signaling Genotoxic Food Sets Off Immune Alarm That Speeds DNA Damage Response in Gut. ...
more infohttps://www.genengnews.com/category/cell-signaling/

Retinal engineering: engrafted neural cell lines locate in appropriate layers | PNASRetinal engineering: engrafted neural cell lines locate in appropriate layers | PNAS

These data show that QNR/D and QNR/K2 cell lines represent distinct neural cell types, suggesting that migrating neural cells ... a putative Müller cell into chicken embryo eyes. Implanted QNR/D cells migrate only to the retinal ganglion and amacrine cell ... Retinal engineering: engrafted neural cell lines locate in appropriate layers Message Subject (Your Name) has sent you a ... Retinal engineering: engrafted neural cell lines locate in appropriate layers. D Trisler, J Rutin, and B Pessac ...
more infohttps://www.pnas.org/content/93/13/6269

Institute of Engineering Thermodynamics - Fuel Cell Research at OldenburgInstitute of Engineering Thermodynamics - Fuel Cell Research at Oldenburg

... system durability is also an important factor in the analysis of profitability of fuel cell components and systems. With our ... At our site in Oldenburg we handle all fuel cell technology related issues regarding a successful market launch. In addition to ... At our site in Oldenburg we handle all fuel cell technology related issues regarding a successful market launch. In addition to ... Alkaline membranes and ionomers for energy application in fuel cells, electrolysis or synthesis as well as redox-flow batteries ...
more infohttps://www.dlr.de/tt/en/desktopdefault.aspx/tabid-13105/22953_read-53293/

3D Cell Culture | GEN - Genetic Engineering and Biotechnology News3D Cell Culture | GEN - Genetic Engineering and Biotechnology News

3D Cell Culture Innovative Method Measures O2 levels in 3D Cells Used for Tox Testing. ... 3D Cell Culture Gain Critical Insights from Advanced Cell Models with Real-Time Analysis. ... 3D Cell Culture Cancer Stem Cells "Hedge" Their Bets with Noncanonical Signaling. ... Israels Sheba Medical Center to Manufacture Cell Therapies Using Lonzas Cocoon Platform. ...
more infohttps://www.genengnews.com/category/cell-culture/3d-cell-culture/?filter_by=random_posts

Engineered Immune Cells Beat Back Cancer - Scientific AmericanEngineered Immune Cells Beat Back Cancer - Scientific American

Both remain disease-free 18 months after treatment and continue to exhibit high levels of the engineered immune cells in their ... The scientists infused the engineered lymphocytes back into their weakened systems and discovered that such cells could persist ... Immune cells such as lymphocytes, also known as T cells and pictured in blue above, recognize health threats via special ... Cancer results from cells gone wild. Proliferating out of control, the cells spawn malignant growths that can travel throughout ...
more infohttps://www.scientificamerican.com/article/engineered-immune-cells-b/

Researchers engineer new thyroid cells | EurekAlert! Science NewsResearchers engineer new thyroid cells | EurekAlert! Science News

... using genetically modified embryonic stem cells. The findings, which appear in the journal Stem Cell Reports, are the first ... step to developing a similar protocol using human stem cells that will allow the modeling of thyroid disease to better ... Researchers have discovered a new efficient way to generate thyroid cells, known as thyrocytes, ... Researchers engineer new thyroid cells. Boston University Medical Center. Journal. Stem Cell Reports. Funder. NIH/National ...
more infohttps://www.eurekalert.org/pub_releases/2017-02/bumc-ren013117.php

Fighting cancer with engineered cancer cellsFighting cancer with engineered cancer cells

The modified cancer cells have demonstrated anti-cancer efficacy in preclinical studies, destroying both primary and metastatic ... Researchers at Brigham and Womens Hospital have engineered cancer cells that track and kill cancer cells. ... Researchers at Brigham and Womens Hospital have engineered cancer cells that track and kill cancer cells. The modified cancer ... With our technique, we show it is possible to reverse-engineer a patients own cancer cells and use them to treat cancer. We ...
more infohttps://www.news-medical.net/news/20180712/Fighting-cancer-with-engineered-cancer-cells.aspx

Fuel Cell EngineeringFuel Cell Engineering

... for Passenger Cars and Electric Vehicles Proton exchange membrane fuel cells (PEMFC) generate efficient ... Fuel Cell Engineering for Heavy-Duty On and Off-Road Vehicles AVL has developed Auxiliary Power Unit (APU) technology based on ... Fuel Cell Solutions for Engineering and Testing With increasingly stringent global emissions legislation and market demands, ... AVL Solid Oxide Fuel Cell Combined Heat and Power AVLs Solid Oxide Fuel Cell Combined Heat and Power (AVL SOFC CHP) stationary ...
more infohttps://www.avl.com/fuel-cell-engineering1

Fuel Cell EngineeringFuel Cell Engineering

... for Passenger Cars and Electric Vehicles Proton exchange membrane fuel cells (PEMFC) generate efficient ... Fuel Cell Solutions for Engineering and Testing With increasingly stringent global emissions legislation and market demands, ... AVL provides high-end customer-specific PEMFC engineering solutions ranging from computational cell/stack/system development ... PEM Fuel Cell Systems for Trucks and Buses Clean power for all applications. ...
more infohttps://www.avl.com/it/fuel-cell-engineering2

Fuel Cell Technology - College of Engineering and Computing | University of South CarolinaFuel Cell Technology - College of Engineering and Computing | University of South Carolina

Solid Oxide Fuel Cell Center of Economic Excellence. Director: Kenneth Reifsnider, NAE, professor, Mechanical Engineering ... Director: John W. Weidner, professor and chair, Chemical Engineering The mission of the Center for Fuel Cells is to help ... Electrical Engineering*Degree Programs*B.S. - Electrical Engineering*Career Plans*Design ICs for Secure Communications ... The Solid Oxide Fuel Cell Center is a faculty cluster and research facility that is dedicated to the science and engineering ...
more infohttp://www.sc.edu/study/colleges_schools/engineering_and_computing/research/focusareas/fuelcell/index.php

Stem Cell Engineering: Principles and Practices, 1st Edition (Hardback) - RoutledgeStem Cell Engineering: Principles and Practices, 1st Edition (Hardback) - Routledge

... and differentiation must be more precisely controlled to maximize the production of therapeutically relevant cells and for cell ... While the potential of stem cells is recognized, their proliferation ... Systems-Engineering Principles in Signal Transduction and Cell-Fate Choice, Karin J. Jensen, Anjun K. Bose, and Kevin A. Janes ... Engineering the Pluripotent Stem Cell Niche for Directed Mesoderm Differentiation, Céline L. Bauwens, Kelly A. Purpura, and ...
more infohttps://www.routledge.com/Stem-Cell-Engineering-Principles-and-Practices-1st-Edition/Schaffer-Bronzino-Peterson/p/book/9781439872048
  • CellNet can be used for interrogation of cell fate following expression profiling, by classifying input by cell type, quantifying gene regulatory network status, and identifying aberrant regulators affecting the engineering process. (phys.org)
  • The network biology platform contains data on a wide range of cells and details on what is known about those cell types. (phys.org)
more