Methods and techniques used to modify or select cells and develop conditions for growing cells for biosynthetic production of molecules (METABOLIC ENGINEERING), for generation of tissue structures and organs in vitro (TISSUE ENGINEERING), or for other BIOENGINEERING research objectives.

Engineering supported membranes for cell biology. (1/57)

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Influence of collagen and chondroitin sulfate (CS) coatings on poly-(lactide-co-glycolide) (PLGA) on MG 63 osteoblast-like cells. (2/57)

Poly-(lactide-co-glycolide) (PLGA) is an FDA-approved biodegradable polymer which has been widely used as a scaffold for tissue engineering applications. Collagen has been used as a coating material for bone contact materials, but relatively little interest has focused on biomimetic coating of PLGA with extracellular matrix components such as collagen and the glycosaminoglycan chondroitin sulfate (CS). In this study, PLGA films were coated with collagen type I or collagen I with CS (collagen I/CS) to investigate the effect of CS on the behaviour of the osteoblastic cell line MG 63. Collagen I/CS coatings promoted a significant increase in cell number after 3 days (in comparison to PLGA) and after 7 days (in comparison to PLGA and collagen-coated PLGA). No influence of collagen I or collagen I/CS coatings on the spreading area after 1 day of culture was observed. However, the cells on collagen I/CS formed numerous filopodia and displayed well developed vinculin-containing focal adhesion plaques. Moreover, these cells contained a significantly higher concentration of osteocalcin, measured per mg of protein, than the cells on the pure collagen coating. Thus, it can be concluded that collagen I/CS coatings promote MG 63 cell proliferation, improve cell adhesion and enhance osteogenic cell differentiation.  (+info)

Concise review: Human cell engineering: cellular reprogramming and genome editing. (3/57)

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Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells. (4/57)

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Introduction to induced pluripotent stem cells: advancing the potential for personalized medicine. (5/57)

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Integration-free iPS cells engineered using human artificial chromosome vectors. (6/57)

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Experimental evolution of a facultative thermophile from a mesophilic ancestor. (7/57)

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Glycoengineering of HCELL, the human bone marrow homing receptor: sweetly programming cell migration. (8/57)

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Cell engineering is a branch of biotechnology that involves the manipulation and modification of cells to achieve desired functions or characteristics. This can be accomplished through various techniques, including genetic engineering, gene editing, cell culturing, and tissue engineering. The goal of cell engineering may be to develop new therapies for diseases, create cells or tissues that can replace damaged ones in the body, or to better understand how cells function.

In genetic engineering, genes are introduced into cells using vectors such as plasmids or viruses. These genes can encode for specific proteins or enzymes that can help the cell perform a particular function, such as producing a therapeutic protein or breaking down a toxic substance. Gene editing techniques, such as CRISPR-Cas9, allow for precise editing of an organism's genome, enabling the correction of genetic mutations or the introduction of new traits.

Cell culturing involves growing cells in controlled conditions outside of the body, allowing researchers to study their behavior and properties. Tissue engineering combines cell engineering with materials science to create functional tissues or organs that can be used for transplantation or other medical applications.

Overall, cell engineering has the potential to revolutionize medicine by enabling the development of personalized therapies, regenerative medicine, and new treatments for a wide range of diseases and conditions.

... improving monoclonal antibody production using engineered cells In vivo cell factories: engineering cells to produce ... Institute for Cell Engineering at Johns Hopkins University School of Medicine Cell & Tissue Engineering at University of ... changing cell growth and proliferation requirements, adding or removing cell functions, and many more. Cell engineering often ... "Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells". Protein & Cell. 13 (7): ...
Because CAR-T cells attack cancerous cells at a surface level, this leaves the CAR-T cells vulnerable to cancerous cell ... PMID 33824268.{{cite journal}}: CS1 maint: multiple names: authors list (link) "CAR T Cells: Engineering Immune Cells to Treat ... These gels suspend CAR-T cells in various ways through manipulation of cell-specific chemistry or by fixing the cells in a ... Production of CAR-T cells involve removal of T cells via an extraction process known as leukapheresis, followed by cell culture ...
Engineering. Chinese Academy of Engineering + Higher Education Press (Elsevier). 5 (1): 32-39. doi:10.1016/j.eng.2018.11.011. ... Glucagonoma Beta cell Delta cell List of human cell types derived from the germ layers List of distinct cell types in the adult ... Alpha cellscells) are endocrine cells that are found in the Islets of Langerhans in the pancreas. Alpha cells secrete the ... Alpha cells are endocrine cells, meaning they secrete a hormone, in this case glucagon. Alpha cells store this glucagon in ...
... mechanical modulation of cell shape and gene expression". Tissue Engineering Part A. 14 (9): 1573-80. doi:10.1089/ten.tea. ... Osteochondroprogenitor cells are progenitor cells that arise from mesenchymal stem cells (MSC) in the bone marrow. They have ... Sox9 blocked osteochondroprogenitor cells were found to express osteoblast marker genes, reprogramming the cells into the ... "Loss of Smad3-Mediated Negative Regulation of Runx2 Activity Leads to an Alteration in Cell Fate Determination". Molecular Cell ...
Doble, Mukesh; Gummadi, Sathyanarayana N. (5 August 2010). Biochemical Engineering. New Delhi: Prentice-Hall of India Pvt.Ltd. ... Direct cell-cell contact is when a receptor on a cell binds a molecule that is attached to the membrane of another cell. ... Cell signaling or cell communication is important for cell regulation and for cells to process information from the environment ... and cell composition. The study of cells is performed using several microscopy techniques, cell culture, and cell fractionation ...
Yen AH, Sharpe PT (January 2008). "Stem cells and tooth tissue engineering". Cell and Tissue Research. 331 (1): 359-372. doi: ... Cell bank Human genome Meristem Mesenchymal stem cell Ovarian stem cell Partial cloning Plant stem cell Stem cell controversy ... from adult cells. These are not adult stem cells, but somatic cells (e.g. epithelial cells) reprogrammed to give rise to cells ... mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, dental pulp stem cell, etc.). Muse cells (multi- ...
"A blueprint for engineering cell fate: current technologies to reprogram cell identity". Cell Research. 23 (1): 33-48. doi: ... May 2013). "TAP-deficient human iPS cell-derived myeloid cell lines as unlimited cell source for dendritic cell-like antigen- ... June 2014). "Human somatic cell nuclear transfer using adult cells". Cell Stem Cell. 14 (6): 777-80. doi:10.1016/j.stem.2014.03 ... June 2013). "Human embryonic stem cells derived by somatic cell nuclear transfer". Cell. 153 (6): 1228-38. doi:10.1016/j.cell. ...
Man, Alan (2011). "Neurite Outgrowth in Fibrin Gels Is Regulated by Substrate Stiffness". Tissue Engineering. 17 (23 and 24): ... Cell-cell adhesions provide chemical and mechanical connections between adjacent cells. Of special importance to neuronal ... Cell migration is generally classified with four cell processes: Leading edge protrusion Adhesion formation Cell body ... Force transmission can occur through a variety of mechanisms, though adhesion complexes between cell-cell and cell- ...
"Scaling Up Cell Therapy Manufacturing". Genetic Engineering and Biotechnology News. 7 September 2018. "Cell Therapy Process ... Jing D, Parikh A, Canty JM, Tzanakakis ES (December 2008). "Stem cells for heart cell therapies". Tissue Engineering. Part B, ... Cell therapy (also called cellular therapy, cell transplantation, or cytotherapy) is a therapy in which viable cells are ... cells or attracting cells to migrate towards the transplantation site. Early cell passages have been shown to be more efficient ...
... ex vivo engineering of living tissues with adult stem cells". Tissue Engineering. 12 (11): 3007-3019. doi:10.1089/ten.2006.12. ... these cells have the same ability as embryonic stem cells to develop into many different cell types. Olfactory stem cells hold ... such as mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, etc.). A great deal of adult stem cell ... Pluripotent stem cells, i.e. cells that can give rise to any fetal or adult cell type, can be found in several tissues, ...
CS1 maint: DOI inactive as of August 2023, Cell culture, Cell biology, Microfluidics, Biological engineering, Fluid mechanics, ... 107 cells); this can make studying certain cell-cell interactions more accessible. These reduced cell numbers make studying non ... cell-cell interactions, cell-molecule interactions, cell-substrate interactions), and physicochemical (pH, CO2, temperature, O2 ... Gel free 3D cell cultures have been developed to allow cells to grow in either a cell dense environment or an ECM poor ...
This early use of electrospun fibrous lattices for cell culture and tissue engineering showed that various cell types including ... cell-cell/cell-matrix interaction, and/or cell migration, but the available assays are not optimized for 3D cell culturing. ... Cell culture Cell lines Cell culture assay Hydrogel Madin-Darby Canine Kidney cell line Microphysiometry Fey S, Wrzesinski K ( ... In living tissue, cells exist in 3D microenvironments with intricate cell-cell and cell-matrix interactions and complex ...
Printable solar cells just got a little closer. Univ. of Toronto Engineering News (2017-02-16). Retrieved on 2018-04-11. Liao, ... They also combined the bottom cell with a ~1.58 eV bandgap perovskite top cell to create an all-perovskite tandem solar cell ... cell Emerging photovoltaics Hybrid solar cell List of types of solar cells Methylammonium lead halide Nanocrystal solar cell ... bottom cells, respectively. A 13.4% efficient tandem cell with a highly efficient a-Si:H/c-Si heterojunction bottom cell using ...
MCFs is a derivation of cell factories, which are engineered microbes and plant cells. In 1980s and 1990s, MCFs were originally ... "CRISPR/Cas9 advances engineering of microbial cell factories". Metabolic Engineering. 34: 44-59. doi:10.1016/j.ymben.2015.12. ... In microbial cells, the cell walls are either Gram-positive or Gram-negative. These outcomes are based on the Gram Stain test. ... A Gram-negative cell wall is more resistant to such attacks and more difficult to destroy. The membrane of microbial cells are ...
Microelectronic Engineering. 144: 42-45. doi:10.1016/j.mee.2015.02.022. ISSN 0167-9317. PMC 4567073. PMID 26412914. Lovchik, ... A majority of cell culturing has been carried out by introducing the cells in a perfused conditioned medium to simulate the ... Cell culturing on paper-based microfluidic devices is accomplished either by encapsulating cells in a hydrogel or directly ... The challenge to support the cell growth and simultaneously study multiple cell types in a single device with an exposed ...
High temperature PEM fuel cells - degradation & durability : dissertation submitted to the Faculty of Engineering and Science ... HT-PEM fuel cell was developed in 1995 for operation at higher cell temperatures aiming at lower sensitivity of PEM fuel cells ... Thus HT-PEM fuel cell technology is one of the youngest fuel cell types and HT-PEM fuel cell systems are produced since the ... More cells needed compared to LT-PEM fuel cell for reaching high power output or same efficiency as for hydrogen LT-PEM fuel ...
... therapy uses T cells engineered with CARs to treat cancer. The premise of CAR T immunotherapy is to modify T cells ... chimeric T cell receptors or artificial T cell receptors-are receptor proteins that have been engineered to give T cells the ... with about half of cell therapy-based trials involving other platforms such as NK cells. T cells are genetically engineered to ... "The Principles of Engineering Immune Cells to Treat Cancer". Cell. 168 (4): 724-740. doi:10.1016/j.cell.2017.01.016. PMC ...
Research in tissue engineering, stem cells and molecular biology primarily involves cultures of cells on flat plastic dishes. ... cells Cell-to-cell contact can stimulate cell cycle arrest, causing cells to stop dividing, known as contact inhibition. Cell- ... These cells may be cells isolated from a donor organism (primary cells) or an immortalised cell line. The cells are bathed in a ... Plant cell lines Tobacco BY-2 cells (kept as cell suspension culture, they are model system of plant cell) Other species cell ...
In 1932, English engineer Francis Thomas Bacon successfully developed a 5 kW stationary fuel cell. The alkaline fuel cell (AFC ... A fuel cell forklift (also called a fuel cell lift truck) is a fuel cell-powered industrial forklift truck used to lift and ... The fuel cell was a stack design that allowed the fuel cell to be integrated with the plane's aerodynamic surfaces. Fuel cell- ... "Asia Pacific Fuel Cell Technologies, Ltd. --fuel cell systems and fuel cell powered vehicles". Archived from the original on 1 ...
doi:10.1016/B978-0-12-383860-5.00004-3. Keith Scott, Lei Xing (2012). "3.1 Introduction". Fuel Cell Engineering. p. 147. doi: ... March 2010 Fuel Cell News Today. An internet portal of news and articles of fuel cell developments 12th Small Fuel Cells. ... Direct-methanol fuel cells or DMFCs are a subcategory of proton-exchange fuel cells in which methanol is used as the fuel. ... Alkali anion exchange membrane Dynamic hydrogen electrode Fuel cell Glossary of fuel cell terms Liquid fuels Methanol (data ...
... which is a desirable property for engineering of optimal solar cells. CZTS also has a high light absorption coefficient. Other ... while antimony-based cells have reached 9.9%. Dye-sensitized cells, also known as Grätzel cells or DSPV, are innovative cells ... As of 2019, single-crystalline GaAs cells have shown the highest solar cell efficiency of any single-junction solar cell with ... and CZTS thin-film solar cells. Thin-film cells have several advantages over first-generation silicon solar cells, including ...
Karel, Steven (1985). "The immobilization of whole cells: Engineering principles". Chemical Engineering Science. 40 (8): 1321- ... Immobilized cell technology is a method of air filtration and purification that uses whole cell immobilization. It is a process ... Oxidation through immobilized cell technology is 12 times more efficient than natural oxidation is under the same conditions. ... As air moves through an immobilized cell technology system, those charged particles are attracted to a water cascade, that ...
Yue P.L. and Lowther K. (1986). Enzymatic Oxidation of C1 compounds in a Biochemical Fuel Cell. The Chemical Engineering ... Microbial fuel cell (MFC) is a type of bioelectrochemical fuel cell system also known as micro fuel cell that generates ... Most microbial cells are electrochemically inactive. Electron transfer from microbial cells to the electrode is facilitated by ... The United States Navy is considering microbial fuel cells for environmental sensors. The use of microbial fuel cells to power ...
It represents a new class of solar cells with clear advantages in performance, engineering design, operation and cost. For ... Meanwhile, the cells are rigid, heavy and thick with a bottom layer made of germanium. In the new method, the cell is grown ... This has the interesting effect of making the cell sensitive from both the front and rear of the cell (a property known as ... By turning the conventional approach to cells on its head, the result is an ultra-light and flexible cell that also converts ...
"Cryopreserved amniotic fluid-derived cells: a lifelong autologous fetal stem cell source for heart valve tissue engineering". ... There is some debate whether c-Kit is a suitable marker to distinguish amniotic stem cells from other cell types because cells ... Evidence in favour of their embryonic stem cell nature is the cells' ability to produce clones. The use of amniotic stem cells ... "Amniotic Fluid-Derived Stem Cells for Cardiovascular Tissue Engineering Applications". Tissue Engineering. 19 (4): 368-379. doi ...
Micro and Nano Engineering. 15 (2022). Zborowski, M (2011). Magnetic Cell Separation. Elsevier. p. 229. Alves, M (2019). " ... This causes the cells expressing this antigen to attach to the magnetic nanoparticles. After incubating the beads and cells, ... Magnetic-activated cell sorting (MACS) is a method for separation of various cell populations depending on their surface ... Nevertheless, in those cells that initiate the apoptotic process phosphatidylserine instead faces the cell membrane outer side ...
Series A, Mathematical, Physical, and Engineering Sciences. 366 (1878): 3111-3136. doi:10.1016/j.cpc.2009.07.019. PMID 18565813 ... Since they account for individual behavior at the cell level such as cell proliferation, cell migration or apoptosis, cell- ... update the position of each vertex according to tensions in the cell membrane resulting from cell-cell adhesion forces and cell ... in order to account for cell-cell communication. As such, cell-based models have been used to study processes ranging from ...
Cell Research and Applications for the Next Decade". Annals of Biomedical Engineering. 37 (5): 847-859. doi:10.1007/s10439-009- ... A unique tool for exploring cell and tissue mechanics in vivo", Methods in Cell Biology, Cell Polarity and Morphogenesis, ... Infected red blood cells are generally stiffer, so through his device, stiffer red blood cells would be closer to the vessel ... The relative deformation of the cell and the tip can be used to estimate how much force was applied and how stiff the cell is. ...
"Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics". Journal of Biomechanical Engineering. ... Cell Migration Gateway The Cell Migration Gateway is a comprehensive and regularly updated resource on cell migration The ... "What is Cell Migration?". Cell Migration Gateway. Cell Migration Consortium. Archived from the original on 22 October 2014. ... March 2011). "Cell physician: reading cell motion. A mathematical diagnostic technique through analysis of single cell motion ...
Engineering of Stem Cells. pp. 185-199. Bibcode:2009esc..book..185M. doi:10.1007/10_2008_45. ISBN 978-3-540-88805-5. PMC ... Cell potency is a cell's ability to differentiate into other cell types. The more cell types a cell can differentiate into, the ... In cell biology, a unipotent cell is the concept that one stem cell has the capacity to differentiate into only one cell type. ... A close synonym for unipotent cell is precursor cell. Biology portal Induced stem cells Cell totipotency was discovered by ...
... improving monoclonal antibody production using engineered cells In vivo cell factories: engineering cells to produce ... Institute for Cell Engineering at Johns Hopkins University School of Medicine Cell & Tissue Engineering at University of ... changing cell growth and proliferation requirements, adding or removing cell functions, and many more. Cell engineering often ... "Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells". Protein & Cell. 13 (7): ...
Cell sheet engineering on Materials Today - the gateway for biomaterials journal articles. ... Home » Biomaterials » Journal articles » Cell sheet engineering Cell sheet engineering. Volume 7, Issue 5, Page 42-47 , ... The confluent cells are noninvasively harvested as single, contiguous cell sheets with intact cell-cell junctions and deposited ... Our concept is tissue reconstruction, not from single cells, but from cell sheets. Cell sheets are prepared using temperature- ...
CAR T-Cell Therapy for Solid Tumors Gets Boost from Cytokine Receptors ... Astellas and Kelonia Partner for $800M In Vivo CAR T Cell Therapies ...
Bone tissue engineering represents one of the most challenging emergent fields for scientists and clinicians. Current failures ... Adipose mesenchymal stem cells in the field of bone tissue engineering World J Stem Cells. 2014 Apr 26;6(2):144-52. doi: ... Keywords: Adipose-derived stem cells; Bone tissue engineering; Osteogenic differentiation; Regenerative medicine; Scaffold. ... These adipose stem cells (ASCs) can be obtained in large quantities with little donor site morbidity or patient discomfort, in ...
... Renewable Energy ... Photovoltaic Cell Businesses in the World. Renewable Energy Engineering Businesses in the World. ... Solar Energy Engineering Businesses in India Solar Energy Engineering Businesses in India by Type of Solar Energy Product ... Product types: Solar Power project MW EPC photovoltaic cells monocrystalline silicon, photovoltaic cells polycrystalline ...
165 million for cell engineering University of Pennsylvania spinout uses mRNA and targeted lipid nanoparticles for cell therapy ... The T cells took up and expressed the mRNA, which encoded for a chimeric antigen receptor that led the T cells to a target ... Capstan Therapeutics has launched with $165 million for in vivo cell engineering to treat disease. The start-ups technology is ... Capstan instead is developing in vivo CAR therapies, in which cells are engineered while they remain in the body. ...
Building stem cell niches from the molecule up through engineered peptide materials.. Return to Grants ... This brief review focuses on engineered peptide and protein materials suitable for use as in vitro neural stem cell niche ... This brief review focuses on engineered peptide and protein materials suitable for use as in vitro neural stem cell niche ... Recapitulating this niche is a critical focus within the fields of stem cell biology, tissue engineering, and regenerative ...
Reimagining cell engineering with picodroplet microfluidic technology. Reimagining cell engineering with picodroplet ... Within picodroplets, single cells are assayed to identify specific proteins to find rare cells of interest or cells with high ... Cell engineering is being held back by lengthy and complicated multi-step workflows. Sphere Fluidics Cyto-Mine® system offers ... Cell engineering is bringing life science into a new era of biotherapeutic discovery and development, disease modelling, and ...
Engineering circadian biology into induced pluripotent stem cell organ-on-a-chip models ... This award aims to introduce circadian rhythmicity to induced pluripotent stem cell (iPSC)-derived organ-on-a-chip models to ... David will demonstrate the utility of the model in drug evaluation by inducing circadian rhythms in the cells and monitoring ... tag key genes that control circadian rhythms in human iPSCs before differentiating into endothelial and smooth muscle cells and ...
Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas Eintrag beim MDC-Dokumentenserver ... We found that these targeted NK cells were specifically activated upon recognition of all evaluated HER-2 positive tumor cells ... Finally, these receptor transduced NK cells, but not their mock transduced counterpart, efficiently eradicated tumor cells in ... Yet, NK cells cannot respond to many tumors, which is particularly the case for nonhematopoietic tumors such as carcinomas or ...
Multipotent stem cells, such as mesenchymal stem cells (MSCs), and pluripotent stem cells, such as embryonic stem cells (ESCs ... Induced pluripotent stem cells in cartilage tissue engineering: A Literature Review Amani Yousef Owaidah Amani Yousef Owaidah ... Amani Yousef Owaidah; Induced pluripotent stem cells in cartilage tissue engineering: A Literature Review. Biosci Rep 2024; ... Current attempts in cartilage regeneration are cell-based therapies using stem cells. ...
See SCS Engineers study on landfill design patterns: Herringbone versus chevron contours, leachate collection pipes & divider ... SCS and SCS Engineers are registered trademarks of Stearns, Conrad & Schmidt, Consulting Engineers, Inc. See the Terms of Use ... The pattern at the base can easily be duplicated in either direction of the cell area, developing a multi-cell design ... representing the divider berms separating adjacent cells). The zig-zag lines in the pattern remind landfill engineers of the ...
Flexible solar cell powered LED I want to make flexible solar cell-powered LED. The flexible solar cell that I want to use is ... Each cell is a Dye-sensitised solar cell and gives out around 0.5v. Because of the placement of the cells around ... ... Newest solar-cell questions feed Subscribe to RSS Newest solar-cell questions feed To subscribe to this RSS feed, copy and ... How can I convert 1v-1.3v at 5a-6a from two solar cells in series and supply 5v out? Each cell is supplying 0.5v-0.65v and ...
Wanner Engineering introduces Hydra-Cell Metering Solutions P400 Pumps with optimized diaphragm valve pocket. ... Wanner Engineering says that the seal-less design of Hydra-Cell means that there are no dynamic or mechanical seals, cups or ... Wanner Engineering Hydra-Cell Metering Solutions P400 Pumps Decrease Risk Of Pump Pack-Out And Vapor Lock ... Wanner Engineering, Inc. announces a significant improvement to its Hydra-Cell Metering Solutions Model P400 pumps. Geometry ...
The article explains how to choose the appropriate genetic engineering tool for CAR-T cells. Read the article here ... ISREC / News /Choosing the right genetic engineering tool for CAR-T cells ... Choosing the right genetic engineering tool for CAR-T cells. Date de publication ... The article explains how to choose the appropriate genetic engineering tool for CAR-T cells. ...
Official website of the Group of Discrete Event Systems Engineering, University of Zaragoza. ... 2009 GISED - Group of Discrete Event Systems Engineering , Contact , Web design: Idibay Consulting ... Time and Supervisory Control of Manufacturing Systems: a Flexible Manufacturing Cell experience Title. Time and Supervisory ...
Engineers create artificial skin that can send pressure sensation to brain cell 16. 10. 2015 , Phys.org , www.phys.org ... Engineers create artificial skin that can send pressure sensation to brain cell ... Stanford engineers have created a plastic "skin" that can detect how hard it is being pressed and generate an electric signal ... Zhenan Bao, a professor of chemical engineering at Stanford, has spent a decade trying to develop a material that mimics skins ...
The technique opens new possibilities for tissue engineering, including approaches to promote wound healing, repair blood ... precisely directing the cells movements by manipulating electric fields to mimic those found in the body during healing. ... Princeton researchers have created a device that can herd groups of cells like sheep, ... Graduate student Gawoon Shim is investigating how varying levels of cell-cell adhesion impact directed cell migration - key ...
... TOPICS:BiosensorCancerMIT ... Be the first to comment on "MIT Engineers Boost Signals From Fluorescent Sensors - Offering Unique Glimpse Inside Living Cells" ... Possible New Route for Cancer Therapy After Engineers Track Evolution of Individual Cell ... provide a unique glimpse inside living cells. However, they typically can only be used in cells grown in a lab dish or in ...
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DPA Magazine the engineers guide to new products and design ideas ... Electric vehicles, fuel cells and bio fuels: competitors or ... The subject of a free Institution of Engineering Technology (IET) event, which takes place on Wednesday November 16 2011 at the ... Fuel cell powered by dirt offers sustainable alternative to batteries(18/01/2024). ... Mouser Electronics leads engineers into the future with immersive technology resource hub ...
Tissue-Engineered Thyroid Cell Sheet Rescued Hypothyroidism in Rat Models After Receiving Total Thyroidectomy Comparing with ... On the other hand, transplantation of the thyroid cell sheets was able to restore the thyroid function 1 week after the cell ... a novel tissue engineering approach. The cell suspension obtained from rat thyroid gland was cultured on temperature-responsive ... from which confluent cells detach as a cell sheet simply by reducing temperature without any enzymatic treatment. The 8-week- ...
... as well as cells, which is essential to maintain cellular viab ... as well as cells, which is essential to maintain cellular viab ... Microchannel, Microfluidic devices, Diseases and conditions, Drug delivery, Organs, Endothelium, Tissue engineering, Cell ... Engineering of vascularized 3D cell constructs to model cellular interactions through a vascular network Special Collection: ... Emi Sano, Chihiro Mori, Yuji Nashimoto, Ryuji Yokokawa, Hidetoshi Kotera, Yu-suke Torisawa; Engineering of vascularized 3D cell ...
Stem cell therapy, regenerative medicine, biomedical engineering, tissue engineering, interdisciplinary collaboration, stem ... merging engineering and biology for groundbreaking treatments. Explore innovative applications and collaborative initiatives ... cell research, innovative treatments, cross-disciplinary approaches, personalized healthcare, free quote ... Discover the transformative potential of cross-disciplinary approaches to stem cell therapy, ...
Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy. ... Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy. ... Adoptive immunotherapies using T cells genetically redirected with a chimeric antigen receptor (CAR) or T cell receptor (TCR) ... Finally, treatment of established B cell acute lymphoblastic leukemia was superior using anti-CD19 CAR-modified T cells ...
Theoretical Device Engineering for High‐Performance Perovskite Solar Cells Using CuSCN as Hole Transport Material Boost the ... Theoretical Device Engineering for High‐Performance Perovskite Solar Cells Using CuSCN as Hole Transport Material Boost the ... Theoretical Device Engineering for High‐Performance Perovskite Solar Cells Using CuSCN as Hole Transport Material Boost the ... Recently, perovskite solar cells (PSCs) have achieved remarkable power conversion efficiency (PCE) about 22.6%. While most of ...
... demonstrating the potential of these cells bone engineering. ... Human fetal bone cells seeded in a hyaluronic acid gel as a ... Human Fetal Bone Cells Seeded in Hyaluronic Acid Gel As A Delivery System For Bone Engineering. Poster Published: September 10 ... demonstrating the potential of these cells bone engineering. ... Human fetal bone cells seeded in a hyaluronic acid gel as a ...
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Regarding fuel cells, several degradation phenomena can occur in a short or long term. Short-term phenomena are generally ... In order to mitigate the impact of aging on the fuel cell system performance, good corrective actions must be taken. To do so, ... In this paper a verified and tested prognosis approach applicable to fuel cells is presented. The novelty in the approach used ... the performance prediction during the aging of the fuel cell system must be conducted. ...
Engineered human pluripotent stem cell derived cardiomyocyte platforms to detect cardiovascular safety liabilities ... Firth, Karl (2017) Engineered human pluripotent stem cell derived cardiomyocyte platforms to detect cardiovascular safety ... The ability to convert human induced pluripotent stem cells into cardiomyocytes (hiPSC-CMs) could provide an alternative ... as well as the use of customisable surface micro-patterning to induce alignment of the cells. The screening platform was then ...
  • Please see the Technical Report: Occupational Exposure Sampling for Engineered Nanomaterials released in July 2022. (cdc.gov)
  • Therapeutic T cell engineering: altering T cells to target cancer-related antigens for treatment Monoclonal antibody production: improving monoclonal antibody production using engineered cells In vivo cell factories: engineering cells to produce therapeutics within the patient's body Directed stem cell differentiation: using external factors to direct stem cell differentiation Cameron, Douglas C. (wikipedia.org)
  • However, since the discovery of human induced pluripotent stem cells (hiPSCs) in 2007, it was seen as a potential source for regenerative chondrogenic therapy as it overcomes the ethical issues surrounding the use of ESCs and the immunological and differentiation limitations of MSCs. (portlandpress.com)
  • This literature review focuses on chondrogenic differentiation and 3D bioprinting technologies using hiPSCS, suggesting them as a viable source for successful tissue engineering. (portlandpress.com)
  • A literature search was conducted using scientific search engines, PubMed, MEDLINE, and google scholar databases with the terms "Cartilage tissue engineering" and " stem cells" to retrieve published literature on chondrogenic differentiation and tissue engineering using MSCs, ESCs, and hiPSCs. (portlandpress.com)
  • These biomimetic scaffolds serve as platforms for delivering stem cells to target tissues, facilitating their engraftment, proliferation, and differentiation into functional cell types. (medicaltourism.com)
  • These intradermal epithelial structures, such as sebaceous glands, sweat glands, and hair follicles, are lined with epithelial cells with the potential for division and differentiation. (medscape.com)
  • Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
  • Much of the recent research on stem cell therapies and treatments falls under the aforementioned cell engineering methods. (wikipedia.org)
  • Capstan says its initial focus is on chimeric antigen receptor (CAR) therapies, in which certain cells, usually T cells, are modified with receptors that allow them to attack and disable harmful antigens like cancer cells. (acs.org)
  • Capstan instead is developing in vivo CAR therapies, in which cells are engineered while they remain in the body. (acs.org)
  • Current attempts in cartilage regeneration are cell-based therapies using stem cells. (portlandpress.com)
  • Engineering principles play a pivotal role in enhancing the efficacy, safety, and scalability of stem cell therapies. (medicaltourism.com)
  • Collaborative initiatives between engineers, biologists, clinicians, and industry partners have accelerated the translation of stem cell therapies from bench to bedside. (medicaltourism.com)
  • Stem cells from dental tissues have a real potential in Advanced Therapies. (bvsalud.org)
  • NK cells are promising effectors for tumor adoptive immunotherapy, particularly when considering the targeting of MHC class I low or negative tumors. (mdc-berlin.de)
  • Recapitulating this niche is a critical focus within the fields of stem cell biology, tissue engineering, and regenerative medicine and requires the development of well-defined, tunable materials. (ca.gov)
  • Traditionally, stem cell research has primarily been rooted in the biological sciences, focusing on understanding the fundamental properties of stem cells and their potential applications in regenerative medicine. (medicaltourism.com)
  • The integration of engineering and biology has fueled innovative approaches in regenerative medicine and drug discovery. (medicaltourism.com)
  • The technique opens new possibilities for tissue engineering, including approaches to promote wound healing, repair blood vessels or sculpt tissues. (princeton.edu)
  • However, they typically can only be used in cells grown in a lab dish or in tissues close to the body's surface, since their signal is lost when they are implanted too deeply. (scitechdaily.com)
  • The presence of functional microvessels was also detected within the engineered thyroid tissues. (researchmap.jp)
  • Moreover, tissue engineering strategies leverage principles of biomechanics and material science to engineer functional tissues and organs ex vivo. (medicaltourism.com)
  • By combining stem cells with biocompatible scaffolds and growth factors, tissue engineers aim to create implantable constructs capable of regenerating damaged or diseased tissues, offering potential solutions for organ transplantation and tissue repair. (medicaltourism.com)
  • Organ-on-a-chip platforms, for instance, replicate the complex microarchitecture and physiological functions of human organs in vitro, allowing researchers to model disease pathogenesis, screen potential therapeutics, and study the interactions between stem cells and host tissues in a controlled environment. (medicaltourism.com)
  • Furthermore, biofabrication techniques, such as 3D bioprinting, enable the precise deposition of cells, biomaterials, and growth factors to create intricately structured tissues and organs. (medicaltourism.com)
  • Mesenchymal Stem Cells (MSCs) can be isolated from several body tissues, including dental tissues. (bvsalud.org)
  • Capstan Therapeutics has launched with $165 million for in vivo cell engineering to treat disease. (acs.org)
  • The team tested SCHEEPDOG using mammalian skin cells and epithelial cells from the lining of the kidney, which are often used to study cells' collective movements. (princeton.edu)
  • Moreover, morphological analyses showed typical thyroid follicle organization, and anti-thyroid-transcription-factor-1 antibody staining demonstrated the presence of follicle epithelial cells. (researchmap.jp)
  • Epidermal appendages are important sources of epithelial cells that re-epithelialize when the overlying epithelium is removed or destroyed in patients with partial thickness burns , abrasions, or split-thickness skin graft harvesting. (medscape.com)
  • We have developed 'cell sheet engineering' in order to avoid the limitations of tissue reconstruction using biodegradable scaffolds or single cell suspension injection. (materialstoday.com)
  • The osteogenic potential of ASCs on scaffolds has been examined in cell cultures and animal models, with only a few cases reporting the use of ASCs for successful reconstruction or accelerated healing of defects of the skull and jaw in patients. (nih.gov)
  • Biomaterials engineering, for instance, involves the design and fabrication of scaffolds that mimic the native tissue microenvironment, providing structural support and cues for guiding stem cell behavior. (medicaltourism.com)
  • The aim of this paper is to provide a review about current and future materials for scaffolds to carry stem cells in tissue engineering in Dentistry, especially for bone tissue repair. (bvsalud.org)
  • MSCs have great therapeutic potential in tissue engineering, they can be expanded in vitro, and combined with scaffolds they can be inserted into wounds to promote healing and tissue replacement. (bvsalud.org)
  • Engineered nanoparticles are unique. (cdc.gov)
  • In this paper, copper thiocyanate (CuSCN), a low cost inorganic HTM with excellent thermal and moisture stability, is applied as HTM for perovskite solar cells. (ucl.ac.uk)
  • Chloride-Based Additive Engineering for Efficient and Stable Wide-Bandgap Perovskite Solar Cells. (bvsalud.org)
  • However, overcoming the significant open-circuit voltage deficit present in wide-bandgap perovskite solar cells remains a major hurdle for realizing efficient and stable perovskite tandem cells . (bvsalud.org)
  • Here, a holistic approach to overcoming challenges in 1.8 eV perovskite solar cells is reported by engineering the perovskite crystallization pathway by means of chloride additives. (bvsalud.org)
  • This brief review focuses on engineered peptide and protein materials suitable for use as in vitro neural stem cell niche mimics and in vivo central nervous system repair. (ca.gov)
  • Taken together, these results indicate that the expression of this activating receptor overrides inhibitory signals in primary human NK cells and directs them specifically toward HER-2 expressing tumor cells both in vitro and in vivo. (mdc-berlin.de)
  • Current in vitro 3D culture models lack a vascular system to transport oxygen and nutrients, as well as cells, which is essential to maintain cellular viability and functions. (aip.org)
  • Furthermore, microfluidic devices, a hallmark of engineering innovation, enable precise control over cellular microenvironments, allowing researchers to mimic physiological conditions and study stem cell behavior in vitro. (medicaltourism.com)
  • With advancements in stem cell technology, the possibility to generate astrocytes in vitro from human pluripotent stem cells (hPSCs), ultimately derived from patient cells, emerged. (lu.se)
  • Recent advancements for tissue regeneration in bone defects have occurred by following the diamond concept and combining the use of growth factors and mesenchymal stem cells (MSCs). (nih.gov)
  • These adipose stem cells (ASCs) can be obtained in large quantities with little donor site morbidity or patient discomfort, in contrast to the invasive and painful isolation of bone marrow MSCs. (nih.gov)
  • Multipotent stem cells, such as mesenchymal stem cells (MSCs), and pluripotent stem cells, such as embryonic stem cells (ESCs), have been used to regenerate cartilage. (portlandpress.com)
  • We recapitulated a bone-like microenvironment by culturing multicellular spheroids containing osteo-differentiated mesenchymal stem cells (MSCs), as well as endothelial cells, and fibroblasts in the device. (aip.org)
  • We demonstrated that migration rates of the breast cancer cells towards multicellular spheroids via blood vessels were significantly higher in the bone-like microenvironment compared with the microenvironment formed by undifferentiated MSCs. (aip.org)
  • The confluent cells are noninvasively harvested as single, contiguous cell sheets with intact cell-cell junctions and deposited extracellular matrix (ECM). (materialstoday.com)
  • The cell suspension obtained from rat thyroid gland was cultured on temperature-responsive culture dishes, from which confluent cells detach as a cell sheet simply by reducing temperature without any enzymatic treatment. (researchmap.jp)
  • CEL today, is pioneer in the country and a leading manufacturer in the world for manufacturing Mono Crystalline Silicon Solar Cells/Modules. (sourceguides.com)
  • Udhaya Semiconductors Limited (USL) established in 1984 manufactures Crystalline silicon solar cells and Solar PV Modules for terrestrial applications. (sourceguides.com)
  • Metal halide perovskite based tandem solar cells are promising to achieve power conversion efficiency beyond the theoretical limit of their single-junction counterparts. (bvsalud.org)
  • Sickle cell anemia is the most severe form of sickle cell disease , a group of inherited red blood cell disorders causing unusually shaped, hard, and sticky red blood cells. (cdc.gov)
  • It is being explored in research and clinical trials for a wide variety of diseases, including single-gene disorders such as cystic fibrosis , hemophilia , and sickle cell disease . (medlineplus.gov)
  • Yet, NK cells cannot respond to many tumors, which is particularly the case for nonhematopoietic tumors such as carcinomas or melanoma even when these cells lose MHC class I surface expression. (mdc-berlin.de)
  • Recognising the challenges associated with traditional bioprocessing methods, Sphere Fluidics has developed Cyto-Mine ® , a novel single cell analysis system that uses picodroplet microfluidic technology to create an integrated and automated workflow for single cell genome editing, from intracellular delivery through to clonality verification. (ddw-online.com)
  • Currently, genome editing is used in cells and animal models in research labs to understand diseases. (medlineplus.gov)
  • Most of the changes introduced with genome editing are limited to somatic cells, which are cells other than egg and sperm cells (germline cells). (medlineplus.gov)
  • Germline cell and embryo genome editing bring up a number of ethical challenges, including whether it would be permissible to use this technology to enhance normal human traits (such as height or intelligence). (medlineplus.gov)
  • Based on concerns about ethics and safety, germline cell and embryo genome editing are currently illegal in the United States and many other countries. (medlineplus.gov)
  • Hsu PD, Lander ES, Zhang F. Development and applications of CRISPR-Cas9 for genome engineering. (medlineplus.gov)
  • It demonstrates a technique to address not just individual cells' activities in response to bioelectric cues, but the action of a cell collective, which is essential to understand how physical forces play into the kind of cooperativity we see in embryogenesis, regeneration and cancer. (princeton.edu)
  • Engineering advance allows particles to be placed deeper within biological tissue, which could aid with cancer diagnosis or monitoring. (scitechdaily.com)
  • Patients with this type of cancer usually undergo surgery to remove as much of the tumor as possible, then receive the chemotherapy drug temozolomide (TMZ) to try to eliminate any remaining cancer cells. (scitechdaily.com)
  • This method can be used to study cancer cell migration towards 3D co-culture spheroids through a vascular network. (aip.org)
  • After the formation of vascularized spheroids, breast cancer cells were injected into a microchannel connected to a vascular network and cultured for 7 days on-chip to monitor cellular migration. (aip.org)
  • Interviewed employees were concerned about cancer risk, upper airway irritation from exposure to sulfuric acid mist, and safety when working in cell rooms. (cdc.gov)
  • Cell engineering often makes use of DNA technology to achieve these modifications as well as closely related tissue engineering methods. (wikipedia.org)
  • Cell engineering can be characterized as an intermediary level in the increasingly specific disciplines of biological engineering which includes organ engineering, tissue engineering, protein engineering, and genetic engineering. (wikipedia.org)
  • The field of cellular engineering is gaining more traction as biomedical research advances in tissue engineering and becomes more specific. (wikipedia.org)
  • Bone tissue engineering represents one of the most challenging emergent fields for scientists and clinicians. (nih.gov)
  • In this study, as a more effective therapy, we have tried to reconstruct the three-dimensional thyroid tissue by the cell sheet technology, a novel tissue engineering approach. (researchmap.jp)
  • Tissue engineering is an interdisciplinary field that involves mainly medical area, biology and engineering. (bvsalud.org)
  • The uses of stem cells in bioengineering have been much investigated and it is showing a promising research line also in tissue engineering, although there are some controversies and discussions. (bvsalud.org)
  • The article explains how to choose the appropriate genetic engineering tool for CAR-T cells. (isrec.ch)
  • Temperature-responsive polymers are covalently grafted onto the dishes, allowing various types of cells to adhere and proliferate at 37°C. The cells spontaneously detach when the temperature is reduced below 32°C without the need for proteolytic enzymes. (materialstoday.com)
  • We found that these targeted NK cells were specifically activated upon recognition of all evaluated HER-2 positive tumor cells, including autologous targets, as indicated by high levels of cytokine secretion as well as degranulation. (mdc-berlin.de)
  • The magnitude of this specific response correlated with the level of HER-2 expression on the tumor cells. (mdc-berlin.de)
  • Finally, these receptor transduced NK cells, but not their mock transduced counterpart, efficiently eradicated tumor cells in RAG2 knockout mice as visualized by in vivo imaging. (mdc-berlin.de)
  • Cell engineering is bringing life science into a new era of biotherapeutic discovery and development, disease modelling, and synthetic biology research. (ddw-online.com)
  • The study "adds to the growing appreciation of cells' responses to bioelectric aspects of their environment," said Michael Levin, who directs the Center for Regenerative and Developmental Biology at Tufts University and was not involved in the research. (princeton.edu)
  • However, recent advancements have underscored the importance of cross-disciplinary collaborations, particularly between engineering and biology, in harnessing the full therapeutic potential of stem cells. (medicaltourism.com)
  • This article explores the convergence of engineering and biology in the realm of stem cell therapy, highlighting the synergistic benefits and innovative approaches emerging from this interdisciplinary partnership. (medicaltourism.com)
  • Studies of fundamental astrocyte biology in humans and their role in neurological disease have been hindered by shortage of native human astrocytes for research purposes and inadequate animal and cell models. (lu.se)
  • The journal is devoted to the promotion of pharmaceutical sciences and related disciplines (including biotechnology, cell and molecular biology, medical and other life sciences, and related engineering fields). (who.int)
  • Therefore, we targeted primary human NK cells by gene transfer of an activating chimeric receptor specific for HER-2, which is frequently overexpressed on carcinomas. (mdc-berlin.de)
  • Adoptive immunotherapies using T cells genetically redirected with a chimeric antigen receptor (CAR) or T cell receptor (TCR) are entering mainstream clinical practice. (jci.org)
  • D ) Fold expansion and ( E ) transduction efficiency of unfractionated PBL genetically engineered with a second-generation 28z anti-CD19 chimeric antigen receptor (CAR) following ex vivo expansion over 10d in the continuous presence IL-2 and AKTi or Veh. (jci.org)
  • Closely tied with the field of biotechnology, this subject of cell engineering employs recombinant DNA methods to induce cells to construct a desired product such as a protein, antibody, or enzyme. (wikipedia.org)
  • Cell sheets are prepared using temperature-responsive culture dishes. (materialstoday.com)
  • Stem cells are unique in that they may differentiate into various other types of cells which may then be altered to produce novel therapeutics or provide a foundation for further cell engineering efforts. (wikipedia.org)
  • 2023). Intelligent, socially oriented technology VI: Projects by teams of master level students in cognitive science and engineering [Course anthology]. (lu.se)
  • Before the announcement in February 1997 of the cloning of a sheep by somatic cell nuclear transfer, existing legislation in a number of countries already precluded human cloning for reproductive purposes, sometimes implicitly. (who.int)
  • Cell engineering is the purposeful process of adding, deleting, or modifying genetic sequences in living cells to achieve biological engineering goals such as altering cell production, changing cell growth and proliferation requirements, adding or removing cell functions, and many more. (wikipedia.org)
  • Because of the biological engineering focus on improving scale-up costs, research in this area is largely focused on the ability of various enzymes to metabolize low-cost substrates. (wikipedia.org)
  • The first use of the term in a biological context was in 1971 in a paper which describes methods to graft reproductive caps between algae cells. (wikipedia.org)
  • Despite the rising popularity of the phrase, there remains unclear boundaries between cell engineering and other forms of biological engineering. (wikipedia.org)
  • The resulting materials often combine the advantages of biological matrices with the engineering control of synthetic polymers. (ca.gov)
  • He has over 40 years of research and professional experience in mechanical, structural, and civil engineering. (scsengineers.com)
  • Wanner Engineering says that the seal-less design of Hydra-Cell means that there are no dynamic or mechanical seals, cups or packing to leak, wear or replace. (chemicalprocessing.com)
  • Previous systems for studying cells' responses to electric fields have been "either bespoke and handmade, with issues of reproducibility, or requiring fabrication facilities that make them expensive and inaccessible to many labs," said co-lead author Tom Zajdel , a postdoctoral research fellow in mechanical and aerospace engineering . (princeton.edu)
  • There are a lot of unknowns about how individual cells detect such fields," said senior author Daniel Cohen , an assistant professor of mechanical and aerospace engineering. (princeton.edu)
  • One general form of cell engineering involves altering natural cell production to achieve a more desirable yield or shorter production time. (wikipedia.org)
  • One distinct section of cell engineering involves the alteration and tuning of stem cells. (wikipedia.org)
  • of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)
  • The native stem cell niche is a dynamic and complex microenvironment. (ca.gov)
  • This powerful and sensitive approach offers many benefits over conventional techniques, including a high-throughput workflow to search much larger populations, a precisely defined and controlled microenvironment for cells, highly concentrated volumes to increase detection sensitivity, and low operating costs. (ddw-online.com)
  • To learn more at SLAS, Richard Hammond, Sphere Fluidics' Chief Technical Officer will be presenting "High-throughput cell engineering in microfluidic picodroplets" at 17:30 - 17:50 on Monday 27th February, in the Exhibition Theatre or visit Booth 411. (ddw-online.com)
  • By integrating microfluidic platforms with advanced imaging techniques and biosensors, scientists can monitor and manipulate stem cell responses in real-time, unlocking insights into cellular dynamics and optimizing therapeutic interventions. (medicaltourism.com)
  • Finally, much progress has been made in engineering cells to produce antigens for the purpose of creating vaccines. (wikipedia.org)
  • Multicellular spheroids containing endothelial cells and lung fibroblasts were embedded within a hydrogel inside a microchannel, and then, endothelial cells were seeded into both sides of the hydrogel so that angiogenic sprouts from the cell spheroids and the microchannels were anastomosed to form a 3D vascular network. (aip.org)
  • Furthermore, evidence of monoclonality must be provided for all cell lines producing biotherapeutic molecules if they are to receive approval from industry regulators. (ddw-online.com)
  • Fluorescent sensors, which can be used to label and image a wide variety of molecules, provide a unique glimpse inside living cells. (scitechdaily.com)
  • Scientists use many different kinds of fluorescent sensors, including quantum dots, carbon nanotubes, and fluorescent proteins, to label molecules inside cells. (scitechdaily.com)
  • To study processes at the level of single molecules and single cells, the tools need to be on the same size scale as the objects under study. (lu.se)
  • However, standard technologies used to ensure the highest value cells are progressed require multistep operations and instruments, extensive hands-on time, and lengthy liquid handling processes, as well as complex, low throughput bioassays for functional validation and verification. (ddw-online.com)
  • We have performed extensive phenotypic and functional characterization to confirm an astrocytic identity of the obtained cells. (lu.se)
  • Within picodroplets, single cells are assayed to identify specific proteins to find rare cells of interest or cells with high productivity. (ddw-online.com)
  • Microbial proteins such as single-cell proteins (SCPs) have been introduced as feed alternatives since they can replace current fish feed ingredients, e.g., soybean, which are associated with negative environmental impacts. (lu.se)
  • We recommend that employees with job titles exceeding the OELs for manganese wear a minimum of a NIOSH-approved half-mask air purifying respirator with N95 or higher filter efficiency until engineering controls reduce exposure below the OELs. (cdc.gov)
  • Professor David Lee and colleagues will luminescently tag key genes that control circadian rhythms in human iPSCs before differentiating into endothelial and smooth muscle cells and growing them in an organ-on-a-chip device. (nc3rs.org.uk)
  • Recent biomaterial design strategies seek to create engineered matrices that interact with cells at the molecular scale and allow on-demand, cell-triggered matrix modifications. (ca.gov)
  • Peptide and protein engineering can accomplish these goals through the molecular-level design of bioinductive and bioresponsive materials. (ca.gov)
  • For example, researchers were able to overexpress transporter genes in hamster ovary cells to increase monoclonal antibody yield. (wikipedia.org)
  • The antibody targets the nanoparticle to T cells, says scientific cofounder Jonathan Epstein, who is the chief scientific officer at Penn's Perelman School of Medicine. (acs.org)
  • In addition to cell engineering, the technology is being increasingly adopted within workflows, demonstrating significant savings in time and costs throughout antibody discovery and cell line development processes, to unlock the full potential of biopharmaceutical discovery. (ddw-online.com)
  • The new system, assembled from inexpensive and readily available parts, enables researchers to manipulate and measure cultured cells' movements in a reliable and repeatable way. (princeton.edu)
  • We therefore develop micro and nanofluidic devices on scales ranging from tens of nanometers to hundreds of micrometers to manipulate, visualize and sort biomolecules, cells and other bioparticles. (lu.se)
  • Multidisciplinary teams collaborate to design innovative delivery systems, optimize cell culture protocols, and conduct preclinical studies to evaluate safety and efficacy profiles. (medicaltourism.com)
  • The combination of inductive scaffold materials with stem cells might optimize the approaches for bone regeneration. (bvsalud.org)
  • Thus, inhibition of signaling along the PI3K/AKT axis represents a generalizable strategy to generate large numbers of receptor-modified T cells with an early memory phenotype and superior antitumor efficacy. (jci.org)
  • Pharmacologic inhibition of AKT signaling permits expansion of CD62L-expressing receptor-engineered human peripheral blood T cells. (jci.org)
  • By changing cell needs, the raw material cost, equipment expenses, and skill required to grow and maintain cell cultures can be significantly reduced. (wikipedia.org)
  • Herein, we report that AKT signaling inhibition is compatible with CAR and TCR retroviral transduction of human T cells while promoting a CD62L-expressing central memory phenotype. (jci.org)
  • Human fetal bone cells seeded in a hyaluronic acid gel as a delivery system, can survive and proliferate within this gel, are positive for alkaline phosphatase and von Kossa staining, demonstrating the potential of these cells bone engineering. (technologynetworks.com)
  • In conclusion, our results indicate that thyroid cell sheets transplanted in a model of total thyroidectomy can reorganize histologically to resemble a typical thyroid gland and restore thyroid function in vivo. (researchmap.jp)
  • However, changes made to genes in egg or sperm cells or to the genes of an embryo could be passed to future generations. (medlineplus.gov)
  • Picodroplet microfluidics is rapidly becoming the technology of choice for single-cell analysis, providing an easy-to-use tool to encapsulate single cells in picolitre-volume aqueous droplets at high throughput rates of thousands of droplets per second. (ddw-online.com)
  • Rather than just simply automating traditional workflows, Sphere Fluidics has developed its systems to facilitate rapid, high-throughput single cell manipulation and analysis across an expanding range of research areas. (ddw-online.com)
  • Single cell experiments [ 11 ] could provide iterative validation of models with experimental results. (lu.se)
  • In this study, we are the first to confirm that engineered thyroid tissue can repair hypothyroidism models in rats and, therefore, cell sheet transplantation of endocrine organs may be suitable for the therapy of hormonal deficiency. (researchmap.jp)
  • Biomedical imaging techniques, such as magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET), play a crucial role in tracking stem cell fate post-transplantation. (medicaltourism.com)
  • In contrast, ectopic overexpression of cell lineage-specific transcription factors can fast forward this process. (lu.se)
  • Ident- cult to deduce interaction rules from observations of the ified transcription factors for specific cell fates are, for entire system. (lu.se)
  • Wanner Engineering, Inc. announces a significant improvement to its Hydra-Cell Metering Solutions Model P400 pumps. (chemicalprocessing.com)
  • If you have a fluorescent sensor that can probe biochemical information in cell culture, or in thin tissue layers, this technology allows you to translate all of those fluorescent dyes and probes into thick tissue," says Volodymyr Koman, an MIT research scientist and one of the lead authors of the new study. (scitechdaily.com)
  • Stanford engineers have created a plastic "skin" that can detect how hard it is being pressed and generate an electric signal to deliver this sensory input directly to a living brain cell. (odbornecasopisy.cz)
  • Scientists have long known that naturally occurring electrochemical signals within the body can influence the migration, growth and development of cells - a phenomenon known as electrotaxis. (princeton.edu)
  • Sickle cell anemia, which primarily affects Black people, can shorten life expectancy by more than 20 years. (cdc.gov)
  • Sickle cell anemia, which primarily affects Black or African American people, is associated with a shorter life span and life-threatening complications that can affect all parts of the body. (cdc.gov)
  • interactions between cells. (lu.se)
  • Mutations in p53, found in most cancers, lead to uncontrollable cell division. (medscape.com)
  • and stem cell regeneration. (lu.se)

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