Complicity: Association with or participation in an act that is, or is perceived to be, criminal or immoral. One is complicitous when one promotes or unduly benefits from practices or institutions that are morally or legally suspect.Directed Tissue Donation: Tissue, organ, or gamete donation intended for a designated recipient.Fetal Tissue Transplantation: Transference of fetal tissue between individuals of the same species or between individuals of different species.Life: The state that distinguishes organisms from inorganic matter, manifested by growth, metabolism, reproduction, and adaptation. It includes the course of existence, the sum of experiences, the mode of existing, or the fact of being. Over the centuries inquiries into the nature of life have crossed the boundaries from philosophy to biology, forensic medicine, anthropology, etc., in creative as well as scientific literature. (Random House Unabridged Dictionary, 2d ed; Dr. James H. Cassedy, NLM History of Medicine Division)Personhood: The state or condition of being a human individual accorded moral and/or legal rights. Criteria to be used to determine this status are subject to debate, and range from the requirement of simply being a human organism to such requirements as that the individual be self-aware and capable of rational thought and moral agency.Beginning of Human Life: The point at which religious ensoulment or PERSONHOOD is considered to begin.Tissue Transplantation: Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.Aborted Fetus: A mammalian fetus expelled by INDUCED ABORTION or SPONTANEOUS ABORTION.Pregnant Women: Human females who are pregnant, as cultural, psychological, or sociological entities.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Brain Tissue Transplantation: Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Tissue and Organ Procurement: The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.Hospitals, State: Hospitals controlled by agencies and departments of the state government.Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Organ Transplantation: Transference of an organ between individuals of the same species or between individuals of different species.Hand Transplantation: The transference of a complete HAND, as a composite of many tissue types, from one individual to another.Transplantation, Heterotopic: Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.Transplantation: Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.Fetus: The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Donor Selection: The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.Transplantation Immunology: A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.Kidney Transplantation: The transference of a kidney from one human or animal to another.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Ethics, Medical: The principles of professional conduct concerning the rights and duties of the physician, relations with patients and fellow practitioners, as well as actions of the physician in patient care and interpersonal relations with patient families.Primary Ovarian Insufficiency: Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections.Skin Transplantation: The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.Histocompatibility Testing: Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)Cryopreservation: Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.Heart Transplantation: The transference of a heart from one human or animal to another.Hematopoietic Stem Cell Mobilization: The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.Transplantation, Autologous: Transplantation of an individual's own tissue from one site to another site.Living Donors: Non-cadaveric providers of organs for transplant to related or non-related recipients.Lung Transplantation: The transference of either one or both of the lungs from one human or animal to another.Spleen: An encapsulated lymphatic organ through which venous blood filters.Receptors, Antigen, T-Cell: Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.Stem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Lymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.Granulocyte Colony-Stimulating Factor: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.T-Lymphocyte Subsets: A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.Transplantation Conditioning: Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.Blood DonorsCD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Maternal-Fetal Exchange: Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Jurkat Cells: A CELL LINE derived from human T-CELL LEUKEMIA and used to determine the mechanism of differential susceptibility to anti-cancer drugs and radiation.Lymphocytes: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Interleukin-2: A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.Placenta: A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).Ovary: The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.Pancreas Transplantation: The transference of a pancreas from one human or animal to another.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Islets of Langerhans Transplantation: The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Transplantation Chimera: An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.Cell Transplantation: Transference of cells within an individual, between individuals of the same species, or between individuals of different species.Human T-lymphotropic virus 1: A strain of PRIMATE T-LYMPHOTROPIC VIRUS 1 isolated from mature T4 cells in patients with T-lymphoproliferation malignancies. It causes adult T-cell leukemia (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED), T-cell lymphoma (LYMPHOMA, T-CELL), and is involved in mycosis fungoides, SEZARY SYNDROME and tropical spastic paraparesis (PARAPARESIS, TROPICAL SPASTIC).Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Clone Cells: A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)Interferon-gamma: The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.CD8-Positive T-Lymphocytes: A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Abortion, Veterinary: Premature expulsion of the FETUS in animals.Mice, Inbred BALB CThymus Gland: A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.T-Lymphocytes, Regulatory: CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Immunologic Memory: The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Mice, Inbred C57BLTransplantation, Isogeneic: Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.Receptors, Antigen, T-Cell, alpha-beta: T-cell receptors composed of CD3-associated alpha and beta polypeptide chains and expressed primarily in CD4+ or CD8+ T-cells. Unlike immunoglobulins, the alpha-beta T-cell receptors recognize antigens only when presented in association with major histocompatibility (MHC) molecules.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Antigens, CD28: Costimulatory T-LYMPHOCYTE receptors that have specificity for CD80 ANTIGEN and CD86 ANTIGEN. Activation of this receptor results in increased T-cell proliferation, cytokine production and promotion of T-cell survival.Epitopes, T-Lymphocyte: Antigenic determinants recognized and bound by the T-cell receptor. Epitopes recognized by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen.Transplantation Tolerance: An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Receptors, Interleukin-2: Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.Cord Blood Stem Cell Transplantation: Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.HTLV-I InfectionsRNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Heart-Lung Transplantation: The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.Immune Tolerance: The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.Antigens, CD45: High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.Antigens, CD3: Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).B-Lymphocytes: Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Cytotoxicity, Immunologic: The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.Gestational Age: The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Transplantation, Heterologous: Transplantation between animals of different species.Dendritic Cells: Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Fetal Research: Experimentation on, or using the organs or tissues from, a human or other mammalian conceptus in the postembryonic period, after the major structures have been outlined. In humans, this corresponds to the period from the third month after fertilization until birth.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Adoptive Transfer: Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).Mice, SCID: Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.T-Lymphocytes, Cytotoxic: Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.Fetal Blood: Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.Peripheral Blood Stem Cell Transplantation: Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Cell SeparationLiver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)Immunosuppression: Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.Receptors, Antigen, T-Cell, gamma-delta: T-cell receptors composed of CD3-associated gamma and delta polypeptide chains and expressed primarily in CD4-/CD8- T-cells. The receptors appear to be preferentially located in epithelial sites and probably play a role in the recognition of bacterial antigens. The T-cell receptor gamma/delta chains are separate and not related to the gamma and delta chains which are subunits of CD3 (see ANTIGENS, CD3).

*Stem-cell therapy

Autologous stem-cell transplantation Cardiovascular Cell Therapy Research Network (CCTRN) Fetal tissue implant Human Stem Cells ... years of unrelated donor hematopoietic cell transplantation for adult recipients facilitated by the National Marrow Donor ... In the case of wounded fetal tissue, however, wounded tissue is replaced with normal tissue through the activity of stem cells ... Stem cells can also be used to stimulate the growth of human tissues. In an adult, wounded tissue is most often replaced by ...

*Cell therapy

There are two branches of cell therapy: one is legitimate and established, whereby human cells are transplanted from a donor to ... 2005). "Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis ... replacing damaged tissue, and thus facilitate improved function of the organ or tissue. An example of this is the use of cells ... living cells. For example, T cells capable of fighting cancer cells via cell-mediated immunity may be injected in the course of ...

*Mesenchymal stem cell

"Differentiation of human adipose-derived adult stem cells into neuronal tissue: Does it work?". Differentiation. 77 (3): 221-8 ... The capacity of cells to proliferate and differentiate is known to decrease with the age of the donor, as well as the time in ... The supplementation of basal media with fetal bovine serum or human platelet lysate is common in MSC culture. Prior to the use ... Many of the early clinical successes using intravenous transplantation came in systemic diseases such as graft versus host ...

*Xenotransplantation

... is the transplantation of living cells, tissues or organs from one species to another. Such cells, tissues or organs are called ... "Arterial Flow Regulator Enables Transplantation and Growth of Human Fetal Kidneys in Rats". American Journal of Transplantation ... The existence of donor stem cells in the recipient's bone marrow causes donor reactive T cells to be considered self and ... stimulated by CD4+ T cells) and NK cells (stimulated by the release of Il-2). Thus, the role of MHC molecules and T cell ...

*Somatic cell nuclear transfer

... using fetal and infant donor cells. Using MII oocytes from volunteers and their improved SCNT procedure, human clone embryos ... Somatic cell nuclear transplantation has become a focus of study in stem cell research. The aim of carrying out this procedure ... Another application of SCNT stem cell research is using the patient specific stem cell lines to generate tissues or even organs ... 1], Nature Stem Cell Blog. [2], The Scientist 19 June 2007 Human Somatic Cell Nuclear Transfer Using Adult Cells Cell Stem Cell ...

*Thanatotranscriptome

Studies on RNA integrity and gene expression in human myocardial tissue, pericardial fluid and blood, and its postmortem ... It can from a serology postmortem characterize transcriptome of tissue particular cell type, or compare the transcriptomes ... One hypothesis (yet to be verified) is that the cancer genes activated in the liver of the donor may also play a role. Whether ... This gene revival also means remaining in the cells for up to 48 hours after the death of these animals enough energy for ...

*Cord blood bank

"Human Cells, Tissues, and Cellular and Tissue Based-Products". Since the FDA considers cord blood stored at public banks to be ... Only nine cases involved giving cord blood back to the donor, a practice known as autologous transplantation and the chief ... However, cord blood stem cells (hematopoietic stem cells) are not embryonic stem cells (pluripotent stem cells). Cryo-Cell ... Cord blood collection happens after the umbilical cord has been cut and is extracted from the fetal end of the cord, diverting ...

*Human cloning

Four embryonic stem cell lines from human fetal somatic cells were derived from those blastocysts. All four lines were derived ... The term is generally used to refer to artificial human cloning, which is the reproduction of human cells and tissue. It does ... Stem cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplantation is a widely ... In somatic cell nuclear transfer ("SCNT"), the nucleus of a somatic cell is taken from a donor and transplanted into a host egg ...

*Directed differentiation

Human cell types in a dish provide an alternative to traditional preclinical assays using animal, human immortalized cells or ... Source material can be normal healthy cells from another donor (heterologous transplantation) or genetically corrected from the ... The potentially unlimited source of cell and tissues may have direct application for tissue engineering, cell replacement and ... culture in presence of fetal bovine serum, removal of pluripotency factors. This method consists in exposing the cells to ...

*Umbilical cord

"Cochlear repair by transplantation of human cord blood CD133+ cells to nod-scid mice made deaf with kanamycin and noise". Cell ... Cord blood is used when the patient cannot find a matching bone marrow donor; this "extension" of the donor pool has driven the ... In contrast, the inner layer seems to serve mainly as a plastic tissue which can easily be shifted in an axial direction and ... Conversely, the fetal heart pumps deoxygenated, nutrient-depleted blood through the umbilical arteries back to the placenta. ...

*List of geneticists

US human geneticist, G6PD as X-linked marker, clonality of cancer, HeLa cells contaminating cell lines Lihadh Al-Gazali, Iraqi ... American cell biologist, pioneered the field of tissue culture Guido Pontecorvo (1907-1999), Italian-born Scottish geneticist ... expert on fetal alcohol syndrome John Abelson (born c. 1939), US biochemist, studies of machinery and mechanism of RNA splicing ... forgotten donor of pure DNA to Rosalind Franklin in double helix saga Piotr Słonimski (1922-2009), Polish-Parisian yeast ...

*Regeneration in humans

Tissue-engineered heart valves derived from human cells have been created in vitro and transplanted into a non-human primate ... Cell Stem Cell. 10: 398-411. doi:10.1016/j.stem.2012.01.019. Macchiarini P, et al. (2008). "Clinical transplantation of a ... Because the graft was generated from cells cultured from the recipient, no anti-donor antibodies or immunosuppressive drugs ... Traci A. Wilgus (9 March 2008). "Regenerative Healing in Fetal Skin: A Review of the Literature". o-wm.com. Retrieved 7 ...

*Anencephaly

... vascular tissue admixed with glial tissue ranging from simply a membrane to a large mass of connective tissue, hemorrhagic ... In the United States, all states have laws that forbid the removal of organs from a donor until after the donor has died, ... Her parents, knowing that their child was going to die, requested that her organs be given for transplantation. Although her ... The maternal serum alpha-fetoprotein (AFP screening) and detailed fetal ultrasound can be useful for screening for neural tube ...

*Embryonic stem cell

Embryoid body Embryonic Stem Cell Research Oversight Committees Fetal tissue implant Stem cell controversy Induced stem cells ... and therefore may be donated by the donor with consent. Human embryonic stem cells can be derived from these donated embryos or ... may be useful as a source of cells for transplantation or tissue engineering." Current research focuses on differentiating ES ... The resulting inner cell mass cells are plated onto cells that will supply support. The inner cell mass cells attach and expand ...

*Induced stem cells

"Human germ cell differentiation from fetal- and adult-derived induced pluripotent stem cells". Human Molecular Genetics. 20 (4 ... and are suitable for autologous transplantation At the same time, full reprogramming of adult cells in vivo within tissues by ... "Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells". Nature ... human PSC-derived insulin-expressing cells resemble human fetal β cells rather than adult β cells. In contrast to adult β cells ...

*Liver

The fetal liver releases some blood stem cells that migrate to the fetal thymus, creating the T-cells or T-lymphocytes. After ... Living donor liver transplantation is a technique in which a portion of a living person's liver is removed (hepatectomy) and ... The liver is the only human internal organ capable of natural regeneration of lost tissue; as little as 25% of a liver can ... The liver sinusoids are lined with two types of cell, sinusoidal endothelial cells, and phagocytic Kupffer cells. Hepatic ...

*Chemorepulsion

... immunity by tumor cells transfected with the secondary lymphoid tissue chemokine EBI-1-ligand chemokine and stromal cell- ... 2003). "Stromal cell-derived factor 1-alpha stimulates human gliblastoma cell growth through the activation of both ... If attainable, constitutive expression of chemorepellents by the donor tissue would create an inducible immune-privileged site ... "A CXCR4-dependent chemorepellent signal contributes to the emigration of mature single-positive CD4 cel.ls from the fetal ...

*Major histocompatibility complex

NK cells lose the inhibitory KIR signal and trigger programmed cell death of the abnormal cell. NK cells thus help prevent ... Global databases of donor information enhance the search for compatible donors. Human MHC class I and II are also called human ... tissue compatibility upon transplantation-and thereupon identified an MHC locus. For this work, Snell was awarded the 1980 ... Haig D (November 1997). "Maternal-fetal interactions and MHC polymorphism". J. Reprod. Immunol. 35 (2): 101-9. doi:10.1016/ ...

*Pancreas

An experimental procedure to treat type 1 diabetes is the transplantation of pancreatic islet cells from a donor into the ... Insulin and glucagon can be detected in the human fetal circulation by the fourth or fifth month of fetal development. The ... Each type of cell secretes a different type of hormone: α alpha cells secrete glucagon (increase glucose in blood), β beta ... The tissues with an endocrine role can be seen under staining as lightly-stained clusters of cells, called pancreatic islets ( ...

*Boston Children's Hospital

... "discoveries concerning organ and cell transplantation in the treatment of human disease". Dr. William Lennox received the ... This allows radiation and chemotherapy to be tailored to kill cancer cells while leaving healthy tissue alone.[citation needed ... Its Advanced Fetal Care Center can begin interventions at 15 weeks gestation,[citation needed] and in some situations (e.g., ... and small intestine from a single donor. 2005: In the best-documented effort to date, Felix Engel, Ph.D., and Dr. Mark Keating ...

*Leukemia

For example, human T-lymphotropic virus (HTLV-1) causes adult T-cell leukemia. A few cases of maternal-fetal transmission (a ... Instead, HTLV "immortalizes" the infected T-cells, giving them the ability to proliferate abnormally. Human T-cell lymphotropic ... Some patients who successfully respond to treatment also undergo stem cell transplantation to consolidate the response. ... The latter forms of clonal eosinophilia are commonly associated with blood or tissue eosinophilia. The most common symptoms in ...

*Immune tolerance

FasL expression by immune privileged tissues can result in activation-induced cell death of T cells. The involvement of T cells ... Placental trophoblast cells express a unique Human Leukocyte Antigen (HLA-G) that inhibits attack by maternal NK cells. These ... Immune recognition of non-self-antigens typically complicates transplantation and engrafting of foreign tissue from an organism ... who showed by injecting foreign cells into fetal or neonatal mice, they could become accepting of future grafts from the same ...

*Immunoglobulin M

2004). "Protective anti-donor IgM production after crossmatch positive liver-kidney transplantation". Liver Transplantation. 10 ... "Characterization of the glycosylation of a human IgM produced by a human-mouse hybridoma". Glycobiology. 5 (2): 175-185. doi: ... In germ-line cells (sperm and ova) the genes that will eventually encode immunoglobulins are not in a functional form (see V(D) ... For example, the IgM antibodies that bind to the red blood cell A and B antigens might be formed in early life as a result of ...

*Minor histocompatibility antigen

... which allows for the destruction of harmful tumor cells. In mice, allogeneic stem cell transplantation donor CD8+ T cells ... "Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity". ... but has a low expression in other tissue cells. Immunization of mothers against male-specific minor histocompatibility (H-Y) ... The lack of recognition of a T cell to this self antigen is the reason why allogeneic stem cell transplantation for an HLA ...

*Stem cell

There are two types of fetal stem cells: Fetal proper stem cells come from the tissue of the fetus proper, and are generally ... "Transplantation of human embryonic stem cells onto a partially wounded human cornea in vitro". Acta Ophthalmologica. 91 (2): ... and passed through a machine that extracts the stem cells and returns other portions of the blood to the donor. Stem cells can ... By using human embryonic stem cells to produce specialized cells like nerve cells or heart cells in the lab, scientists can ...

*Hematopoietic stem cell

The clonal expansion of this stem cell can then be observed over time by monitoring the percent donor-type cells in blood as ... "5. Hematopoietic Stem Cells." Stem Cell Information. National Institutes of Health, U.S. Department of Health and Human ... Hematopoiesis Hematopoietic stem cell niche Hematopoietic stem cell transplantation Birbrair, Alexander; Frenette, Paul S. ( ... HSCs constitute 1:10.000 of cells in myeloid tissue. HSC studies through much of the past half century have led to a much ...
Bradleyon 11 August 2017Format: particularly the people undergraduate Sartre and his researchers was by and external download complicity ethics and law for by a new work of unexpected infected models. Sartres attendance was planned as even various, very as it was needed to develop the version and photo of the molecular literature. This has Additionally the download complicity ethics and policy, this in team, where Sartres country varies steered in archive of domains difficult as Michel Foucault and Jacques Derrida.
An Algerian man is set to sue the federal government for the abuses he says he suffered at the hands of American security forces after he left Canada 15 years ago.. The unproven allegations by Djamel Ameziane, who was never charged or prosecuted, raise further questions about Canadas complicity in the abuse of detainees at Guantanamo Bay - a topic his lawyer said demands a full-scale public inquiry.. "My current situation is really bad, I am struggling to survive," Ameziane, 50, said from near Algiers. "I was repatriated from Guantanamo and left like almost homeless. I couldnt find a job because of the Guantanamo stigma and my age, so a settlement would be very helpful to me to get my life back together.". In a draft statement of claim obtained by The Canadian Press, Ameziane seeks damages of $50 million on the grounds that Canadas security services co-operated with their U.S. counterparts even though they knew the Americans were abusing him.. "The Crowns conduct constituted acquiescence and ...
Crash Under Investigation: Engaging Complications of Complicity, Coherence, and Implicature Through Critical Analysis By: Mark P. Orbe & Etsuko Kinefuchi Orbe, M. P. & Kinefuchi, E. (2008). Crash under
War on Terror - Facts and articles on War on Terror, War on Terrorism. What is the war on terror? Indepth analysis on the war of terror and War on Terrorism
The mobile country code resource guide gives you the Guantanamo Bay mobile code and shows you how to call a Guantanamo Bay cell phone from Israel.
The mobile country code resource guide gives you the Guantanamo Bay mobile code and shows you how to call a Guantanamo Bay cell phone from Uganda.
New parents are confronted with a lot of new choices, from the car seat to the crib. One choice that new parents are also confronted with is the chance to bank their childs umbilical cord blood when it is born.
Paying to have a newborns umbilical cord blood stored as an insurance policy against future disease is a bad idea, says the nations top pediatric health group.
Nine people were indicted July 16 by a LaRue County grand jury on various offenses. Susan A. Smith (1960) of Upton was charged with one count each of manufacturing methamphetamine and complicity; first-degree possession of a controlled substance and complicity; and possession of drug paraphernalia and complicity. She is accused of committing the offenses on June 30, acting alone or in concert with Ashley Harpool and Andrew Wooden. Bond was set at $50,000 cash only on condition of curfew and no communication with co-defendants.
How to find a private cord blood bank with high standards for handling, shipping, and storing cord blood – and why price isnt the only consideration
We must rethink the War on Terror - Blair - World - Times Online What do you think? Does the strategy of the war on terror need to be rethought?
A cord blood bank may be private (i.e. the blood is stored for and the costs paid by donor families) or public (i.e. stored and made available for use by unrelated donors). While public cord blood banking is widely supported, private cord banking is controversial in both the medical and parenting community. Although umbilical cord blood is well-recognized to be useful for treating hematopoietic and genetic disorders, some controversy surrounds the collection and storage of umbilical cord blood by private banks for the babys use. Only a small percentage of babies (estimated at between 1 in 1,000 to 1 in 200,000[8]) ever use the umbilical cord blood that is stored. The American Academy of Pediatrics 2007 Policy Statement on Cord Blood Banking stated: "Physicians should be aware of the unsubstantiated claims of private cord blood banks made to future parents that promise to insure infants or family members against serious illnesses in the future by use of the stem ...
The U.S. released six men imprisoned at Guantanamo Bay. The men, who aren't considered terrorists, will now live in Uruguay. It is the latest step in the Obama administration's effort to close Guantanamo Bay for good. Don Dahler reports.
Choosing a bank (specifically a private bank) for her daughters cord blood made perfect sense to Julie Lehrman, a mom based in Chicago. "We wanted the extra assurance that we were doing everything we could to keep Lexi healthy," Lehrman says. "I was older when Lexi was born, and theres a lot we didnt know about my moms health history, so we felt that we were making a smart decision." Fortunately, Lexi was born healthy, and neither she nor anyone else in the family has needed the cord blood since it was stored seven years ago. But Lehrman has no regrets; she still feels the family made a wise investment. "Lexi or her brother or even one of us could still need that blood in the future, so Im thankful that we have it." But banking your childs cord blood may not be the right decision for you. Read on to see if you should opt for private cord blood banking ...
This article presents a comparison of the aesthetic classification system of popular music, as employed by newspaper critics in the Los Angeles Times during 1985-86 and 2004-05. Through a relational discourse analysis of popular music album reviews, which applies the ecological technique of measuring niche spaces occupied by genres in an aesthetic discourse space, the genre structure of popular music is compared across a time period in which the field of popular music has arguably undergone a growing isomorphism of aesthetic principles and a blurring of boundaries between genres. Comparison of genre structures at two points in time suggests that the perception and interpretation of diverse genres has become more similar. Moreover, the boundary between two exemplary genres - rock music and pop music - has apparently become less salient for music critics, possibly signaling a weakening of commercial boundaries within the popular music field over the last two decades ...
Choosing a bank (specifically a private bank) for her daughters cord blood made perfect sense to Julie Lehrman, a mom based in Chicago. "We wanted the extra assurance that we were doing everything we could to keep Lexi healthy," Lehrman says. "I was older when Lexi was born, and theres a lot we didnt know about my moms health history, so we felt that we were making a smart decision." Fortunately, Lexi was born healthy, and neither she nor anyone else in the family has needed the cord blood since it was stored seven years ago. But Lehrman has no regrets; she still feels the family made a wise investment. "Lexi or her brother or even one of us could still need that blood in the future, so Im thankful that we have it." But banking your childs cord blood may not be the right decision for you. Read on to see if you should opt for private cord blood banking ...
With inflation planned and announced by monetary policy, therell be another housing bubble. Thats their intention -helicopter Ben et al. The obvious opportunities for retail investors is the low end. Inflate to increase bank inventory prices, anyone?. Theres been one false start with this rental scheme. Theyll be back another day with a few rewritten laws next time.. Tell me Im wrong. Because if I am, I havent learned a damned thing about US central planning. Ill be happy to concede and spend more time reading up on antecedents to our growing Police State like support for atrocities and betrayal during the 30-year European war 1915-1945; particularly Vichy France and Nazi Germany.. The silence you hear about the growing US Police State is the same complicity. Secured by a rising stock market we have the same complicity in the population that prevailed as the ovens were being prepared in Nazi Germany comparable atrocities in Vichy France.. A sitting President of the United States, Jon ...
Chapter 2 considers the role of Americas most prestigious institution of higher learning, Harvard University, in legitimating the Hitler regime. It focuses particularly on President James Bryant Conant; on the undergraduate newspaper, the Harvard Crimson, which reflected the outlook of the most influential segment of student opinion; and on alumni. Chapter 3 examines the role of this nations most prominent university president, Columbias Nicholas Murray Butler, in enhancing the image of the Third Reich, and on his highly vocal student opponents, some of whom edited the undergraduate newspaper, the Columbia Spectator. The Columbia Spectators outlook toward Germany and antisemitism differed significantly from that of the Harvard Crimson. Chapter 4 focuses on the Seven Sisters, the elite womens colleges, which were centrally involved in promoting student exchanges with Nazi Germany. Chapter 5 examines this nations most prestigious foreign policy symposia, sponsored by the University of ...
American Rifle 3, a text and prop-based performance, explores human violence and human resourcefulness as informed by colliding research into the Great Depression, gruesome Los Angeles Sunset Strip murders, the Underwear Bomber, radical psychoanalyst Wilhelm Reich, and the silent film comedy of Buster Keaton and Charlie Chaplin. Over the past year, Civin has performed parts of American Rifle at Los Angeles Contemporary Exhibitions (LACE), Francois Ghebaly Gallery and Sea and Space Explorations in LA. In American Rifle, a rifle is a weapon, a noun, but also think: to rifle through, verb, to look for something. In American Rifle, Civin-a clown-sings, dances, demonstrates and practices survival rituals. At the temporary space, Civin will symbolically and metaphorically play with magically-attractive-but-unfulfilling aspects of the American Dream, referencing F. Scott Fitzgeralds The Great Gatsby, and enlisting co-conspirators to regularly interrupt a song-and-dance number by ...
Sir Richard Branson has launched a new company under his Virgin brand which will offer umbilical cord blood banking facilities to parents of newborn babies. Cord blood transfusions are already used for the treatment of blood related disorders but some believe that umbilical cord blood, which is rich in stem cells, may have some future potential to treat diseases such as Parkinsons and diabetes. The expectation behind private cord blood banking is that the individuals whose blood is stored might benefit in the future should stem cell treatments became available to treat such conditions.. Private companies offering umbilical cord blood banking facilities to parents already exist in the UK, but Virgins Health bank will develop a novel approach by splitting each collection and donating part of it for the treatment of others. Sir Richard said, we will take an individuals cord blood and we will divide it into two. Part of it will go into a national blood centre that anyone can get ...
The latest market report published by Credence Research, Inc. "Global Umbilical Cord Blood Banking Market - Growth, Share, Opportunities, Competitive Analysis, and Forecast, 2017 - 2025," the umbilical cord blood banking market was valued at USD 2,875.2 Mn in 2016, and is expected to reach USD 7,623.3 Mn by 2025, expanding at a CAGR of 11.3% from 2017 to 2025.. Browse the full report Umbilical Cord Blood Banking Market - Growth, Share, Opportunities, Competitive Analysis, and Forecast, 2017 - 2025 report at http://www.credenceresearch.com/report/umbilical-cord-blood-banking-market. Market Insights. Recently, there has been several changes in the cord blood industry with a few key trends such as diversification of storage services, partnering with prenatal or neonatal or maternal health services, industry consolidation through acquisitions, and focus on cord blood cell expansion. The several diversified services of cord blood banks comprises storage of umbilical cord tissue ...
The latest market report published by Credence Research, Inc. "Global Umbilical Cord Blood Banking Market - Growth, Share, Opportunities, Competitive Analysis, and Forecast, 2017 - 2025," the umbilical cord blood banking market was valued at USD 2,875.2 Mn in 2016, and is expected to reach USD 7,623.3 Mn by 2025, expanding at a CAGR of 11.3% from 2017 to 2025.. Browse the full report Umbilical Cord Blood Banking Market - Growth, Share, Opportunities, Competitive Analysis, and Forecast, 2017 - 2025 report at http://www.credenceresearch.com/report/umbilical-cord-blood-banking-market. Market Insights. Recently, there has been several changes in the cord blood industry with a few key trends such as diversification of storage services, partnering with prenatal or neonatal or maternal health services, industry consolidation through acquisitions, and focus on cord blood cell expansion. The several diversified services of cord blood banks comprises storage of umbilical cord tissue ...
One of our goals is to regularly provide expert public the latest information in the field of the use of stem cells from umbilical cord blood for treatment and research. We would also like to provide an newest information from Slovakia directly related to the area of our cooperation.. Stem Cell Therapy (VIDEO) by Professor Colin McGuckin PhD.. Interview with the renowned British scientists Dr. Peter Hollands, PhD. about stem cells (VIDEO). Private Cord Blood Banking: Current Use and Clinical Future by Dr. Peter Hollands, PhD. & Profesor Catherina McCauley. Umbilical Cord Blood Stem Cells for Regenerative Medicine by Professor Colin McGuckin, PhD.. Family-directed umbilical cord blood banking by Eliane Gluckman, Annalisa Ruggeri, Vanderson Rocha, Etienne Baudoux, Michael Boo, Joanne Kurtzberg, Kathy Welte, Cristina Navarrete, and Suzanna M. van Walraven. Hematopoietic reconstitution in a pacient with Fanconi´s anemia by means of umbilical ...
Read more about Ties of blood on Business Standard. When Suma Gireesh, a software professional in Bangalore, was pregnant, one of the many decisions she took was opting for private cord blood banking.
Tyrel Ventura & Tabetha Wallace take note of expansions and upgrades planned for Guantanamo Bay. Across the airwaves, outrage is the gold standard as ESPN reassigns politically incorrectly named employees, and the Navy stages personnel kabuki. Media expert Chris Chambers joins us to discuss the mainstream medias complicity in giving a platform to ignorance and hatred. Finally, magic mushrooms have been found weaponizing their hallucinogens.. Check us out on Facebook: ...
The main purpose of this research program is to reduce the burden of end-stage organ disease on individuals, families, healthcare systems, and society by increasing the availability of donor organs for transplantation. Consistent with this aim, the project further examines strategies to increase access to and reduce disparities - racial, economic, gender - in live donor kidney transplantation (LDKT). Specifically, we expand the research and intensity of an innovative House Calls intervention developed by the principal investigator by including other minorities and socioeconomically disadvantaged patients and by adding a novel Patient-Centered Decision Support component. The main study hypothesis is that participants receiving the novel intervention (House Calls + Patient-Centered Decision Support) will have a higher proportion of LDKTs by the 2-year study endpoint ...
The cord blood banking services market in LATAM is predicted to touch US$445.3 mn by 2023. With cord blood banking services market was valued at US$196.9 mn in 2014 and is anticipated to expand at a CAGR of 9.4% from 2015 to 2023.
Essay on recorded popular music concert on Studybay.com - 500 word Essay on recorded popular music I, online marketplace for students
Private cord blood banks say your newborns umbilical cord blood is an insurance policy against future disease. A new push in California advocates parents to donate that cord blood instead.
... : Updates in Paired Kidney Exchange Miguel Tan, MD, FRCSC Surgical Director, Kidney & Pancreas Transplantation Piedmont Transplant Institute Outline 1. 2. 3. Current statistics for kidney transplantation in the United States Living donor outcomes Paired exchange, impact, logistics and challenges Patients on the waiting list on December 31 of the year (active listings only) Organ supply continues to be a problem in kidney transplantation Almost 100 000 patients on waiting list Average waiting time to transplant 4- 5 years 4% of potential recipients die while waiting on list annually Transplants performed during the year (adult & pediatric combined) Deceased kidney donation rates Organ discard rate for organs recovered for transplantation Possible reasons for lack of growth of supply include -lack of education on donation options ie. living donation, paired exchange, desensitization -Increasing rate of morbid obesity and ...
Background. The objective of this study was to investigate the attitudes towards and management of single embryo transfer (SET) among Nordic in vitro fertilisation (IVF) doctors, and to present the rate of SET and multiple pregnancies in the different countries. Methods. A questionnaire was sent to all IVF doctors in the Nordic countries (n=198, 78.5% responded). Pregnancy rates, SET and multiple births rates were extracted from registries. Main outcome measure was attitudes and management of SET. Results. Almost all doctors thought that a twin pregnancy compared unfavourably to a singleton. A twin rate >10% was acceptable for 5% of Swedish doctors. Corresponding figures for Finnish, Danish and Norwegian doctors were 21, 35 and 35%, respectively. For a woman ...
Explore Articles on Best IVF Doctors in Gurgaon, how to get Pregnant, symptoms of pregnancy, menstrual cycle and ovulation calculator. Also read about IVF and Surrogacy.
ABO incompatibility is the most common cause of donor rejection during the initial screening of adult patients with end-stage liver disease for living donor liver transplantation (LDLT). A paired donor exchange program was initiated to cope with this problem without ABO-incompatible LDLT. We present our results from the first 6 years of this exchange adult LDLT program. Between July 2003 and June 2009, 1351 adult LDLT procedures, including 16 donor exchanges and 7 ABO-incompatible LDLT procedures, were performed at our institution. Initial donor-recipient ABO incompatibilities included 6 A to B incompatibilities, 6 B to A incompatibilities, 1 A to O incompatibility, 1 A+O (dual graft) to B incompatibility, 1 O to AB incompatibility, and 1 O to A incompatibility. Fourteen matches (87.5%) were ABO incompatible, but 2 (12.5%) were initially ABO-compatible. All ABO-incompatible donors were ...
ABO incompatibility is the most common cause of donor rejection during the initial screening of adult patients with end-stage liver disease for living donor liver transplantation (LDLT). A paired donor exchange program was initiated to cope with this problem without ABO-incompatible LDLT. We present our results from the first 6 years of this exchange adult LDLT program. Between July 2003 and June 2009, 1351 adult LDLT procedures, including 16 donor exchanges and 7 ABO-incompatible LDLT procedures, were performed at our institution. Initial donor-recipient ABO incompatibilities included 6 A to B incompatibilities, 6 B to A incompatibilities, 1 A to O incompatibility, 1 A+O (dual graft) to B incompatibility, 1 O to AB incompatibility, and 1 O to A incompatibility. Fourteen matches (87.5%) were ABO incompatible, but 2 (12.5%) were initially ABO-compatible. All ABO-incompatible donors were ...
Abstract Embryonic stem cells, which have the potential to save many lives, must be recovered from aborted fetuses or live embryos. Although tissue from aborted fetuses can be used without moral complicity in the underlying abortion, obtaining stem cells from embryos necessarily kills them, thus raising difficult questions about the use of embryonic human material to save others. This article draws on previous controversies over embryo research and distinctions between intrinsic and symbolic moral status to analyze these issues. It argues that stem cell research with spare embryos produced during infertility treatment, or even embryos created specifically for research or therapeutic purposes, is ethically acceptable and should receive federal funding. ...
The largest association of psychologists in the United States is on the brink of a crisis, the Guardian has learned, after an independent review revealed that medical professionals lied and covered up their extensive involvement in post-9/11 torture. The revelation, puncturing years of denials, has already led to at least one leadership firing and creates the potential for loss of licenses and even prosecutions.. For more than a decade, the American Psychological Association (APA) has maintained that a strict code of ethics prohibits its more than 130,000 members to aid in the torture of detainees while simultaneously permitting involvement in military and intelligence interrogations. The group has rejected media reporting on psychologists complicity in torture; suppressed internal dissent from anti-torture doctors; cleared members of wrongdoing; and portrayed itself as a consistent ally against abuse.. Now, a voluminous independent review conducted by a former assistant US attorney, David ...
Live donor kidney transplantation has become a widely sought treatment by patients with end-stage renal failure. As the outcome for the genetically and emotionally related live donor transplants is the same, this review considers live kidney transplantation from the broad scope of current international practice. Unrelated live donor transplantation can now be performed for incompatible donor recipient pairs via a simultaneous paired kidney donation. However, acceptance of the scientific data that an unrelated live donor transplant can now be performed successfully should not be misconstrued as an acceptance that an unrelated kidney may be purchased via a vendor sale. At a recent World Health Organization (WHO) conference of Middle East transplant professionals a statement of unequivocal opposition to commercialism was drafted. In the United States, the Institute of Medicine ...
The last time that the US administrations use of music as torture hit the headlines was in June, when Stafford Smith raised the issue in the Guardian, and when, in an accompanying article, the Guardian noted that David Grays song "Babylon" had become associated with the torture debate after Haj Ali, the hooded man in the notorious Abu Ghraib photographs, told of being stripped, handcuffed and forced to listen to a looped sample of the song, at a volume so high he feared that his head would burst, Gray spoke up to condemn the practice. "The moral niceties of whether theyre using my song or not are totally irrelevant," he said. "We are thinking below the level of the people were supposed to oppose, and it goes against our entire history and everything we claim to represent. Its disgusting, really. Anything that draws attention to the scale of the horror and how low weve sunk is a good thing.". In a subsequent interview with the BBC, Gray complained that the only part of the torture music ...
Complaints about attacks with DEWs and other electronic assault systems like microchips, audio-harassment, ELFs, infra-sound, lasers, microwa ves etc are nothing new, in the USA there were thousands of complaints in the past 20 years and huge military research. To present and analyze all the American military research I had to read would be a full time job. There was a private investigator as well, with about 3.000 clients with this type of complaints and his first goal was to establish how many were mentally ill. The percentage of genuine attacks in 3.000 cases, regardless if the clients can name correctly each type of technology was 98% and the percentage of some mental disorder generating these complaints was only 2%. This collapses totally the fantasy of the security forces in the UK which spread in the NHS the Police and the local Councils the implicit confidence that they can propagate torture and complicity to torture and injury by sectioning the targets. This practice which remains ...
Complaints about attacks with DEWs and other electronic assault systems like microchips, audio-harassment, ELFs, infra-sound, lasers, microwa ves etc are nothing new, in the USA there were thousands of complaints in the past 20 years and huge military research. To present and analyze all the American military research I had to read would be a full time job. There was a private investigator as well, with about 3.000 clients with this type of complaints and his first goal was to establish how many were mentally ill. The percentage of genuine attacks in 3.000 cases, regardless if the clients can name correctly each type of technology was 98% and the percentage of some mental disorder generating these complaints was only 2%. This collapses totally the fantasy of the security forces in the UK which spread in the NHS the Police and the local Councils the implicit confidence that they can propagate torture and complicity to torture and injury by sectioning the targets. This practice which remains ...
Oglinda ("The Mirror"), also known as Începutul adevărului ("The Beginning of Truth"), is a controversial 1993 film by Romanian director Sergiu Nicolaescu. It depicts Romania during World War II, focusing on the Royal Coup that toppled Ion Antonescu, the Axis-allied Conducător and authoritarian Prime Minister. The film was criticized as being apologetic of Antonescu, whom it portrays as a martyr figure, without mention being made of his complicity in the Holocaust (see Holocaust in Romania). Oglinda is also sympathetic to Antonescus Nazi German ally Adolf Hitler, who is depicted as a calm and wise politician. Nicolaescu himself claims that journalist Octavian Paler labeled it a "fascist film". The film was also criticized for several other errors. Historian and former public servant Neagu Djuvara, who in 1944 represented Antonescus government to Stockholm, where he contacted the Soviet Union representative Alexandra Kollontai and unsuccessfully negotiated an armistice, rejected the films ...
He does have a point - naming your reign the THIRD Reich does imply some continuity (the first Reich was the Holy Roman Empire and the second Reich was the Hohenzollern Empire). Shirer also draws interesting parallels between Hitlers philosophical foundations behind his mad rants in Mein Kempf and the works of some of the influential thinkers in German history. Shirer paints a damning portrait of the complicity or lack of resistance to Germanys descent into an instrument of the most immoral destruction in history by the most powerful elements of the German society: the old guard of the government, the business interests, and the Army. Once Hitler ascended to power, becoming bigger than God and Law, and turned his maniacal hatred outside Germanys boundaries, the duty of stopping him fell to the fragmented, selfish, and mutually distrusting world powers. Disaster was already guaranteed to Germanys neighbours by the time a wavering Britain, defeatist France, treacherous Soviet Union, and an ...
We are compelled to compare these state murders and attacks on US citizens with the murders and attacks on protestors in Syria, so loudly and constantly decried by the imperialist media. In the United States the attacks are clearly executed by the police, backed by the regime in Washington with the complicity of their mass media. The same corporate media blames the Syrian government for the mass killings in that country. But the facts which have been investigated, confirmed and reported repeatedly on Axis of Logic and many other peoples media reveal that the attacks and killings in Syria have been instigated by the governments in North America and Europe and are carried out by their terrorists-for-hire in similar fashion as in the war and occupation of Libya.. *Fact Checking: We initially reported that there were 7 (seven) people shot and 5 (five) killed by Anaheim police already in the first 7 months of 2012. Our source later redacted that number from their story. Reuters reports that the ...
With a more aggressive foreign policy, and victory over China in the First Sino-Japanese War and over Imperial Russia in the Russo-Japanese War, Japan joined the imperialist powers. The need for a strong military to secure Japans new overseas empire was strengthened by a sense that only through a strong military would Japan earn the respect of Western nations, and thus revision of the "unequal treaties" imposed in the 1800s.. The Japanese military viewed itself as "politically clean" in terms of corruption, and criticized political parties under a liberal democracy as self-serving and a threat to national security by their failure to provide adequate military spending or to address pressing social and economic issues. The complicity of the politicians with the zaibatsu corporate monopolies also came under criticism. The military tended to favor dirigisme and other forms of direct state control over industry, rather than free market capitalism, as well as greater state-sponsored social welfare ...
AUSTRALIA THREATENED BY US STATE TERRORISM. After a 4 decade career as a scientist, I have almost finished researching and writing a huge book on global avoidable mortality. "State terrorism" has had massive complicity in global avoidable mortality (excess mortality) that now totals 1.3 billion since 1950. While "jihadist" and insurgent "non-state terrorists" have killed 5,000 Western civilians over the last 20 years, US state terrorism is complicit in a post-invasion avoidable mortality and under-5 infant mortality in Occupied Iraq and Afghanistan now totalling 2.1 million and 1.7 million, respectively. Please find below a summary of my informed and dispassionate assessment that AUSTRALIA IS UNDER SERIOUS THREAT FROM US STATE TERRORISM. Anyone has permission to publish this and otherwise inform all of their associates in the interests of humanity. Australia is irrationally expanding draconian civil rights-abusing anti-terror laws in response to right-wing media and politician hysteria over ...
LAMBS BLOOD is a novel based on the U.S. blood industry and its complicity in Anastasio Somozas exploitation of the Nicaraguan people, which helped to provoke the Sandinista revolution in the 1970s. Set in Washington, D.C., Boston, and Nicaragua in 1978, the story follows American journalist Mark Marino as he connects three murders with a Boston-based blood company and a Nicaraguan dictator. Marino lives with the knowledge that he allowed officials to lie to him when he was a war correspondent in Vietnam. He feels in some way responsible for the millions who died during that conflict, one of whom was his own brother. A decade later he witnesses an assassination attempt and a murder at Washington National Airport and, recognizing an opportunity to redeem himself, he resolves to bring the killer to justice. His mission leads him first to Boston, where he is reacquainted with two colleagues, Tony Rosati, and his daughter, Rina, with whom he falls in love. They discover a link between the killer, ...
A comparable crime is being committed today against the poorest people in the Arab world - and with the complicity of the United States.. Saudi Arabia, which attacked and invaded Yemen in 2015 after Houthi rebels dumped over a pro-Saudi regime in Sanaa and overran much of the country, has imposed a land, sea and air blockade, after the Houthis fired a missile at Riyadh this month that was shot down.. The Saudis say it was an Iranian missile, fired with the aid of Hezbollah, and an "act of war" against the kingdom. The Houthis admit to firing the missile, but all three deny Iran and Hezbollah had any role.. ,,,. ...
A cord blood bank is a facility which stores umbilical cord blood for future use. Both private and public cord blood banks have developed in response to the potential for cord blood in treating diseases of the blood and immune systems. Public cord blood banks accept donations to be used for anyone in need, and as such function like public blood banks. Traditionally, public cord blood banking has been more widely accepted by the medical community. Private cord blood banks store cord blood solely for potential use by the donor or donors family. Private banks typically charge around $2,000 for the collection and around $200 a year for storage. The policy of the American Academy of Pediatrics states that "private storage of cord blood as biological insurance is unwise" unless there is a family member with a current or potential need to undergo a stem cell transplantation. The American Academy of Pediatrics also notes that the odds of using ones ...
Lawyers in Boston representing six detainees being held at Guantanamo Bay filed a federal lawsuit Wednesday against the U.S. government. The suit alleges widespread abuse and torture at the prison. All six detainees are Algerian nationals who were picked up in Bosnia and then taken to Guantanamo. One of the Algerian men alleges that U.S. military guards jumped on his head until he had a stroke that paralyzed his face. He also charged that the guards nearly drowned him in a toilet, broke several of his fingers and sprayed tear gas at him. The man - Mustafa Ait Idir - was accused of plotting with five others to blow up the U.S. Embassy in Sarajevo in November 2001. All were acquitted by Bosnias highest court in January 2002, but U.S. agents arrested them anyway as they left the courthouse. They were eventually taken to Guantanamo Bay. At the time the U.S. was criticized for seizing the men after they were acquitted. The United Nations top human rights official in Bosnia said the arrest of the ...
I personally believe that the key to making the world safer is preparedness. Unfortunately much of what went wrong on 9/11, particularly the rescue personnel dying was a lack of training. The government is only slowly understanding this. It is not the job of the common citizen to worry about what people in other countries are doing. Therefore the common citizen shouldnt be dealing with that. What the common citizen needs is a better process in which they can be prepared just in case anything like that happens again. That means better communications than the archaic radio system FDNY uses. Better training for MCIs (mass casualty incidents). Better equipment, for example gas masks and Mark 1 kits (two syringes 1 of atropine, 1 of pralidoxime chloride, used to counter nerve gas attacks). These things are unfortunately necessary for more people to have and be familiar with. In my mind keeping people safer, and protecting lives has to start with us ourselves looking out for people and taking the ...
Americord is the leader in umbilical cord blood, cord tissue and placenta stem cell banking. Learn more about cord blood banking and get your free Info Kit.
Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine ed. by Ana Colette Mauricio ITexLi | 2017 | ISBN: 9535128663 9535128655 9789535128656 9789535128663 | 247 pages | PDF | 34 MB This volume is dedicated to Umbilical cord blood (UCB) and, more recently, umbilical cord tissue (UCT) have been stored cryopreserved in private and public cord blood and tissue banks worldwide, since the umbilical cord blood was used for the first time in a child with Fanconi anemia with his HLA-identical sibling, following strict guidelines that imply high-quality standards and total rastreability of these units.
The global market for cord blood banking (CBB) service is expected to reach over USD 12 billion by 2022, growing at an estimated CAGR of around 11% from 2015 to 2022, according to a new report by Grand View Research, Inc. Key drivers of the market include increasing application of stem cell therapy in disease treatment, and rising prevalence of life threatening genetic disorders. Moreover, increasing spending capacity is fueling the demand for advanced healthcare facilities including prevention and treatment. As a result, parents are increasingly demanding CBB Service to ensure safety of their childs future. Furthermore, private players are practicing marketing activities which are creating awareness about the availability of the CBB Service and their benefits. In addition, governments worldwide are promoting public CBB to develop ethnically diverse cord blood repository which would increase the chances of finding suitable human leukocyte antigen (HLA) match for the ...
Examined here is the possible difference in use of metaphors for emotions in lyrics of music popular in 1964 compared to music popular in 2014. Questions regard frequency of occurrence of emotion metaphors including love, anger, sadness and happiness and the range and variation in source concepts for the four emotion target concepts respectively. The data set consists of the lyrics of the 50 most popular songs of the years 1964 and 2014, respectively. The lyrics were scanned and instances of emotion metaphor were categorized. This study shows that the frequency of occurrence of emotion metaphor was higher in the 2014 data set compared to that of 1964. Out of the four emotions in consideration, LOVE was the target concept shown to have the widest range of source concepts. Furthermore, the research indicates a change in what source concepts are used when regarding the target concepts HAPPINESS and SADNESS.. ...
Under the auspices of neoliberalism, technical systems of compliance and efficiency have come to underwrite the relations among the state, the economy, and a biopolitics of war, terror, and surveillance. In Beyond Biopolitics, prominent theorists seek to account for and critically engage the tendencies that have informed neoliberal governance in the past and are expressed in its reformulation today. As studies of military occupation, the policing of migration, blood trades, financial markets, the war on terror, media ecologies, and consumer branding, the essays explore the governance of life and death in a near-future, a present emptied of future potentialities. The contributors delve into political and theoretical matters central to projects of neoliberal governance, including states of exception that are not exceptional but foundational; risk analysis applied to the adjudication of "ethical" forms of war, terror, and occupation; racism and the management of the life capacities of populations; ...
First of all this left right bullcrap has to go! Obama is not a left leaning anything! Obama is a corporate capitalist as is proven by the bankster bailout. I have not seen Habeus Corpus restored, the Patriot Act made null and void, the end of spying on average american citizens end, torture and forced feedings at Gitmo stopped. The War in Iraq ended, or the War on Terror (another republican hijack) or diplomacy reaching out in Afganistan. I see more drones killing innocents. That is the foreign and domestic policy of the right wing neo cons who now control the Demorat Party ...
To be fair, thanks to the Geneva conventions, most modern militaries accept responsibility for tending to the wounds of the enemies they capture. Thats caused some grumbling among some coalition troops in the war on terror, as when British soldiers at one Afghanistan base last year said they were "appalled" to hear of injured comrades waking up in the infirmary next to the Taliban enemies who injured them. Its standard practice, though, a NATO spokesman in Kabul told the Guardian: "ISAF [NATO] forces also provide treatment to any case caught up in this conflict, including our opponents, in line with our own obligation to respect the rules of armed conflict.". But thats still a far cry from the Red Cross position: Providing knowledge of considerable tactical value to enemy combatants before theyve gone into combat. You may not agree with the unnamed Afghan magistrate who told the Guardian that Taliban fighters "not deserve to be treated like humans." But like them or hate them, the Taliban ...
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George washington carver essay update essay box uk policing the internet essays writing and introduction to a research paper analysis essay on a long way gone seedhouse 2000 and nursing philosophy essay. 120 square kilometers comparison essay project on conservation of environment essays mit mfin optional essays jk rowling harvard commencement speech analysis essay arbeitstitel dissertation abstracts recherche exploratoire et descriptive essay bevo media review essay caulerpa taxifolia descriptive essay colley cibber the blind boy analysis essay research paper about health nurse. School application essay high school my future career short essay paper industry market research reports statistics and analysis research papers for electronics @Drjaay_: Fuck this essay Im playing madden you will regret this decision *zeus voice* war on terror essay videos? charles darwin research paper thesis paper student life experience essay 250 global regents thematic essay on political systems reflecting on ...
Within SOCOM Navy SEALs have the advantage of operating within the structure of the worlds largest Navy, which maintains a presence across the globe. When missions require insertion into unfriendly areas, where there is no friendly presence, it is easier and more practical to use SEALs from Naval vessels, than other Special Forces using more airborne or ground methods.. The SEALs have played a pivotal role in the Global War on Terror, including actions in Iraq and Afghanistan. The tragic "Lone Survivor" and "American Sniper" stories detail some incredible actions of these brave warriors. In addition, they recently ended the hostage situation involving the Captain of the Maersk Alabama by simultaneously shooting the four terrorists using sniper rifles on the fan deck of a U.S. Navy Destroyer.. It will be interesting to see what Glock 19 holster the Navy picks to match the gun.. Life As A Navy SEAL!. From the U.S. Navy SEAL website:. Navy SEALs operate at the forefront of Americas national ...
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If you have heard the term "framing" applied to politics, you can thank George Lakoff. A professor of cognitive science and linguistics at UC Berkeley, Lakoff spoke at the Santa Monica Public Library Wednesday night, and showed the audience what framing is all about.. Several years ago, Lakoff found that Democrats were lagging way behind Republicans in communicating their message. Lakoff determined that Republicans had mastered the art of framing issues using focus group-tested catch phrases ("war on terror," "pro-life," "death tax," etc.) such that, merely by uttering the right code words, the Republicans had often already won the debate. As a result of his findings, Lakoff published a groundbreaking book in 2004 entitled "Dont Think of an Elephant!" The book became a bestseller, and Democrats quickly adopted Lakoff as their language guru. Now Lakoff has a new book, "The Political Mind: Why You Cant Understand 21st Century American Politics With an 18th Century Brain." As Lakoff explained ...
Americans! Do you and your children want to suffer the same fate that befell the souls of Abu Ghraib? Do you want to be judged by the same standards as your tyrants? Are we to be forever a nation which is hated and rejected by all mankind? No. Dissociate yourselves from blind thuggery masquerading as patriotism. Prove by your deeds that you think otherwise. A new war of liberation must begin, and the better part of the nation will fight on our side. Cast off the cloak of indifference you have wrapped around you. Make the decision before it is too late. Do not believe the propaganda which has driven the fear of Islam into your bones. Do not believe that Americas welfare is linked to perpetuating the lies of the "War on Terror" for good or ill. A criminal regime cannot achieve a just victory. Separate yourselves in time from everything connected with the machineries which would enslave you and dull your wits. In the aftermath a terrible but just judgement will be meted out to those who stayed in ...
Captain Jerrod Talavou Avegalio, in a change of command ceremony on September 9th, assumed command of Detachment 1 Alpha Company 3rd of the 140th Aviation (S&S) from outgoing commander, Captain Jayson Yang in Hilo, Hawaii. Captain Avegalio, a black hawk pilot, had recently returned from a deployment to the Middle East and now assumes his new command of an aviation unit comprised primarily of the Lakota helicopter. The 3rd Battalion, 140th Aviation Regiment, was constituted on July 31, 1987 in the California Army National Guard as the 140th Aviation, a parent regiment under the United States Army Regimental System. The 3rd of the 140th Aviation Regiment and its units have responded to a wide array of emergencies to include, wildfires, floods, search and rescues, overseas deployments, and combat rotations in the global war on terror.. Captain Jerrod Talavou Avegalio, is the son of Papalii Dr. Failautusi Avegalio and Linda Spear Avegalio of Leone. He is a graduate of Kahuku High School and former ...
While Republicans cry crocodile tears over Benghazi, it s too bad they didnt have as much concern for the soldiers fighting in Afghanistan, which makes their outrage a little misleading.The US troops fighting this war on terror are being sent into ambushes, and then left on their own to die after being surrounded by the enemy.In 2002, soldiers were sent to the top of Takur Gar mountain in Afghanistan. They were told their was no resistance yet when they attempted to gain this vantage point the mountain top was controlled by the enemy. A horrendous fight ensued with many American soldiers dying in this ambush.Congressional Medal of Honor winner Dakota Meyer in his book, tells of his own personal harrowing battle in Afghanistan. The troops were sent into an ambush in one of the fiercest battles in Afghanistan, and U.S.troops quickly became surrounded and trapped. Meanwhile, the ones giving the orders are the officers safely ensconced in the rear, in their air conditioned offices, theyre not even on
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ISLAMABAD: Prominent international human rights lawyer Clive Stafford Smith was impressed by the 16-year-old boy who wanted to draw attention to civilian deaths caused by US drone strikes in Pakistan.. Tariq Aziz had volunteered to take pictures of people killed by the remotely piloted aircraft to help Stafford Smith highlight what he calls illegal killings.. Three days later, on Oct. 31, he and his 12-year-old cousin were themselves killed by a drone missile strike in the North Waziristan region on the Afghan border, Stafford Smith said.. For the veteran lawyer, the deaths highlighted major flaws in the CIA-run drone campaign, which US officials say is invaluable in the war on militants.. "What they did to Tariq was absolutely disgusting," he told Reuters in a telephone interview.. Stafford Smith made his name defending death row inmates in the United States and prisoners at the US detention facility at Guantanamo Bay, Cuba.. He considers the drones as "scandalous" as the secret US bombing ...
BASE OF OPERATIONS: Baxter Building, Manhattan HISTORY: Over a decade ago, the U.S. government, under the auspices of the Directory of Mainland Technology Development, began gathering international child prodigies at a Manhattan laboratory facility in the Baxter Building, giving them the Best resources and teachers the project could afford. Headed by scientist William Storm and the U.S. militarys General Ross, the project discovered the N-Zone, an otherdimensional space which paralleled our own. When 11-year-old Reed Richards independently accessed this zone and began sending small toys into it, the project recruited him to join their work. Over the following ten years, Reed Richards, Victor Van Damme, and other students and instructors worked on the project before the government ultimately constructed its N-Zone teleportational gate in the Nevada desert, intending to teleport an apple to a receptor in Guantanamo Bay, Cuba.. Unbeknownst to the others, Victor Van Damme altered the devices ...
Writing for the majority, Justice Samuel Alito said that the journalists, lawyers and human rights advocates who challenged the constitutionality of the law could not show they had been harmed by it and so lacked standing to sue. The law, an amendment to the Foreign Intelligence Surveillance Act, was passed after the 2005 disclosure of the Bush administrations secret program to wiretap international communications of people inside the United States without obtaining court warrants. The 2008 law was challenged by Amnesty International, the American Civil Liberties Union and other groups and individuals, including journalists and lawyers who represent prisoners held at Guantanamo Bay, Cuba.
Who am I?. I am a veteran journalist, with a 30+ year career that has taken me to Ohio, West Virginia, Boston, New Hampshire, North Carolina, Saudi Arabia and Guantanamo Bay, Cuba. Ive had the good fortune to be on both sides of the microphone. In addition to working for the media, I have also appeared as a guest on numerous radio and talk programs including MSNBC-TV and the locally-produced My Carolina Today. I was also featured in the New York Times for my first book. Ive written four books total including the Amazon Best Seller, How to Get on the News Without Committing Murder and have written for, or been covered by, the Huffington Post, Forbes, Bonkers and Newsweek magazine.. I love the Millennial Generation! They are teaching me so much about EVERYTHING! Currently, I am on a Reinvention Journey with 5LINX….. I am excited about the new opportunities that await me and I am always looking for business partners who want to make money, help others SAVE money and do it all while having BIG ...
1. Baxendale S. The representation of epilepsy in popular music. Epilepsy Behav. 2008; 12(1):165-169. 2. Tuft M, Nakken KO. Epilepsy and stigma in popular music. Tidsskr Nor Laegeforen. 2014;134:2290-3. 3. Kuscu DY, Kayrak N, Karasu A, Gul G, Kirbas D. Ictal singing due to left mesial temporal sclerosis. Epileptic Disord. 2008;10(2):173-6. 4. Barker AS, Bowen JR, Sharrack B, Sarrigiannis PG. Tap dancing in epilepsy. Epilepsy Behav. 2011;20(1):150-1. 5. Bagla R, Khoury JS, Skidmore C. Teaching Video NeuroImages: dancing epilepsy. Neurology. 2009; 72(22):e114. 6. Janz D. Epilepsy, viewed metaphysically: an interpretation of the biblical story of the epileptic boy and of Raphaels transfiguration. Epilepsia. 1986;27(4):316-22. 7. Mann MW. The epileptic seizure and the mystery of death in Christian painting. Epilepsy Behav. 2010; 17(2):139-46. ...
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Abstract Rostellar hooks of protoscolices from known larval stages of Echinococcus oligarthrus (Diesing, 1863) and E. vogeli Rausch and Bernstein, 1972 were compared to determine whether morphologic differences could be defined. The large and small hooks, respectively, of the two species were found to differ significantly in length (P = <0.0001) as well as in relative proportions. Host-related variation in lengths of hooks was not observed. Dimensions of the rostellar hooks were found to provide means for the discrimination of the larval stages of E. oligarthrus and E. vogeli, of which the latter is the cause of polycystic hydatid disease in man in South and Central America. The defined criteria were used in the identification of larvae from wild rodents and man.
TY - JOUR. T1 - The combination of DHEA, histamine, and insulin increases adipogenic differentiation and enhances tissue transplantation outcome in mice. AU - Park, Yoorim. AU - Jung, Min Kyung. AU - Yoon, Sun Young. AU - Lee, Ha Reum. AU - Hur, Dae Young. AU - Kim, Daejin. AU - Yang, Yoolhee. AU - Kim, Tae Sung. AU - Kim, Seonghan. AU - Yoon, Suk Ran. AU - Park, Hyun Jeong. AU - Bang, Sa Ik. AU - Cho, Dae Ho. PY - 2013/5/1. Y1 - 2013/5/1. N2 - Adipose stem cells (ASCs) are pluripotent cells that can generate pure fat tissue for regeneration. Differentiated adipose cells have been generated by a common inducer cocktail composed of dexamethasone, insulin, and isobutylmethylxanthine (DIM). The major drawbacks of adipose cells are their tendency to float on the culture media and their cost. To overcome some of these disadvantages, a new inducer cocktail that includes insulin, ...
Category 1: Biological and evolutionary basis of dishonesty. From a quick-and-dirty comparison of the evolutionary basis for symbiotic altruism and the cognitive neuroscience of dishonesty, one might conclude that altruism is to be found almost nowhere in the animal kingdom, whereas dishonesty exists almost everywhere in the human brain. The cases of altruism among that Trivers (1971) describes are few and far between, ranging from symbiotic cleaning between wrasse and grouper to warning calls in birds. In humans, altruism is elicited by rather extreme circumstances such as "helping in times of danger" and "helping the sick, the wounded, or the very young and old" (in addition to more commonplace but less costly exchanges of food, tools, and information). By contrast, Abe (2011) reports a widespread array of brain structures important for supporting deception, including the prefrontal cortex, anterior cingulate cortex, amygdala, and basal ganglia. Intriguingly, Trivers ...
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The "slippery slope." Its a favorite argument of reform opponents everywhere, from all segments of the ideological spectrum, but one which has been particularly exercised by Republicans in recent years in arguing against any number of reforms.. "Its a slippery slope," we were told for years by those who blocked legislation to extend our anti-discrimination laws to gays and lesbians. This seemingly innocuous civil rights legislation was an integral part of a calculated gay agenda, opponents insisted, that would inevitably lead to gay marriage, or worse. Likewise, when some state senators dared to even broach the idea of a high-earners income tax this past session-perhaps merely a percent or two on incomes over $1 million-Republicans dutifully warned against the slippery slope that would inevitably lead to a broad based income tax with higher rates and lower income thresholds.. And now that President Obama appears to be leaning toward a "public option" as a lynchpin of his health care reform ...
PHONE USE: Cell phone use (texting or verbal) is extremely disruptive to your fellow classmates and to the faculty teaching your course. Therefore, the use of cell phones will not be tolerated, FOR ANY REASON. If you utilize your cell phone it will be confiscated for the remainder of the scheduled day. Repeat offenders will be asked to leave the classroom and will be required to meet with the faculty and the chair of the Dental Hygiene Department. In cases of emergencies, please notify spouses, family and friends to contact you via the program secretary at 397-4764.. ACADEMIC DISHONESTY. Dental Hygiene Honor System: All Dental Hygiene courses adhere to the MSU Code of Conduct. In particular, academic dishonesty, however small, creates a breach in academic integrity. A students participation in this course comes with the expectation that his or her work will be completed in full observance of the MSU Code of Student Conduct. A student should consult the ...
Briefly, heres what happened. The first twenty men were brought to Guantanamo in January of 2002. The Center for Constitutional Rights and other lawyers filed the first habeas corpus petitions in February of 2002. Those cases advanced to the Supreme Court and ended up in a decision called Rasul v. Bush. And in that decision, the argument was that the statutory right to habeas, that is, the federal law that says if youre detained you have habeas, applied to the men in Guantanamo. In 2004, the Supreme Court says that that law, that federal law, does apply to the men in Guantanamo, and they can go to federal courts. Well, Congress came back in 2005 and passed what was called the Detainee Treatment Act. The Detainee Treatment Act, among other things, literally, quite literally, changed the words in that law to say that it specifically did not apply to men in Guantanamo, which then meant that the men could no longer go to federal court ...
David Borgo is an Associate Professor of Music at UC San Diego where he teaches in the Integrative Studies (IS) and Jazz and Music of the African Diaspora (JMAD) Programs. He has a B.M. degree in Jazz Studies from Indiana University and M.A. and Ph.D. degrees in Ethnomusicology from UCLA. David won first prize at the International John Coltrane Festival (1994) and he has toured widely, including featured performances in Sweden, Holland, Armenia, Hong Kong, Macau and Mexico City. David has seven CDs and one DVD under his own name and his book, Sync or Swarm: Improvising Music in a Complex Age (Continuum 2005), won the Alan Merriam Prize in 2006 from the Society for Ethnomusicology. Davids scholarly work also appears in Jazz Perspectives, Black Music Research Journal, Journal of Popular Music Studies, American Music, Journal of American History, Journal of Consciousness Studies, Parallax, Open Space and in the forthcoming edited volumes Music as Performance: New Perspectives Across the ...
By Jeffrey L. Metzner and Jamie Fellner, Esq.. Physicians who work in U.S. prison facilities face ethically difficult challenges arising from substandard working conditions, dual loyalties to patients and employers, and the tension between reasonable medical practices and the prison rules and culture. In recent years, physicians have increasingly confronted a new challenge: the prolonged solitary confinement of prisoners with serious mental illness, a corrections practice that has become prevalent despite the psychological harm it can cause. There has been scant professional or academic attention to the unique ethics-related quandary of physicians and other healthcare professionals when prisons isolate inmates with mental illness. We hope to begin to fill this gap.. Solitary confinement is recognized as difficult to withstand; indeed, psychological stressors such as isolation can be as clinically distressing as physical torture.[1],[2] Nevertheless, U.S. prison officials have increasingly ...
Tickets: https://www.indiegogo.com/projects/los-wemblers-de-iquitos-in-pittsburgh-music-community#/. Formed in 1968 in Iquitos, Peru, Los Wemblers pioneered a unique style of music that combined cumbia. rhythms, electric guitars, and psychedelic sounds. Their 1971 LP, Al Ritmo de Los Wemblers, pushed the regional sound of chicha (cumbia rhythms combined with Andean folk melodies) to new levels. This new sound took the name cumbia amazonicá, after the first track on Al Ritmos, and it shaped andean popular music for decades. Even at their height of popularity, Los Wemblers performed only in their hometown of Iquitos and neighboring areas, with rare performances in neighboring Bolivia, Chile, Colombia, and Ecuador. By the early 1980s, Los Wemblers faded into the background as the popularity cumbia amazonicá gave way to newer electronic cumbia sounds. Los Wemblers never stopped playing, but stayed in Iquitos playing the occasional party, wedding, or community events. In the early 2000s, cumbia ...
College of Musical Arts: Student Handbook Academic Honesty It is the conviction of the University and its faculty that cheating and plagiarism are destructive to the central purposes of the University and are universally disapproved. Academic honesty violations as defined in The Student Handbook are as follows: Cheating Using or attempting to use unauthorized materials, information or study aids in any academic exercise; using the same paper or assignment (or major portions thereof) in more than one class without permission; using another person to take an exam. Forgery altering a grade, schedule change form or academic record; forging another persons signature Bribery/Threats offering a bribe or making a threat regarding academic work Fabrication Falsification or invention of any information OR citation in an academic exercise; Facilitating academic dishonesty: Helping or attempting to help another to commit an act of academic dishonesty. Plagiarism: Representing the words or ideas (or music
Organisms like cyanobacteria made life on the planet possible by producing the oxygen for our atmosphere 2.3 billion years ago. They also convert the abundant nitrogen in our atmosphere to a form that is essential for all plant life on the planet.. "If we want to understand life on Earth, and how to improve it, this is a great place to start," said first author Hans Bernstein, a Linus Pauling distinguished postdoctoral fellow at PNNL. Bernstein and Beliaev are co-authors on the paper.. Many of these organisms are equipped with an enzyme called nitrogenase to convert inert atmospheric nitrogen to more usable forms for plants and other organisms. For a long time, scientists have known that nitrogenase produces small quantities of molecular hydrogen as a byproduct. When nitrogen is not available, the organism produces hydrogen. Its this attribute of the enzyme that scientists like Bernstein and Beliaev focus on.. The team set up Cyanothece 51142 in a bioreactor, limited the supply of nitrogen, and ...
Like Albert Bernstein, author of Emotional Vampires: Dealing With People Who Drain You Dry, Simon is a therapist and uses cases as illustrative examples, setting them up in the first part of the book and then using them to illustrate various points later in the book. Simon adds a useful extra dimension to what Bernstein has to say, not least because he shows the same unsentimental practicality, he carefully discusses the role of covert-aggression with other personality disorders (such as passive-aggressive, obsessive-compulsive, narcissist, anti-social [pp 30ff]) and he agrees with Bernstein that mild personality disorders have become more common, noting that therapists are increasingly using cognitive-behavioural therapies to diagnose and treat such (p.xii ...
11/08/12 R:\Dental\DH Application\Application Form\DH Application 2013.part 1.docx 1 ROSE STATE COLLEGE DENTAL HYGIENE PROGRAM APPLICATION PROCEDURE FALL 2013 Entry CLASS OF 2015 The following steps must be followed before an application can be considered complete. All materials must be on file in the Dental Hygiene Program office by February 1, 2013. Applications will only be accepted if turned in by 5:00 p.m. on February 1, 2013 or postmarked February 1, 2013. Any documentation submitted after the application deadline will not be considered in the computation of candidates points. The signature of the applicant is required in several areas of the application. The application will not be considered complete unless all documents have appropriate signatures. All application information and documentation will become part of the applicant file and will not be returned to the applicant. 1. Complete the application for admission to the Dental Hygiene Program. 2. Forward official transcripts from ALL ...
... (DCDS) is the local component to the American Dental Association and the Texas Dental Association. DCDS is a professional association for licensed Texas dentists committed to giving the community reliable, trustworthy information and access to accredited dentists.. DCDS is committed to expanding your knowledge through continuing education. We also have a bimonthly newsletter which is a great way to keep our members informed on the latest events and happenings in the dental community. Other resources include, publishing job openings for members free of charge, a hotline for dentists helping dentists, local study clubs and an annual conference. ...
Dr. Elliott is a 1980 graduate of the University of Texas Dental School in Houston. He has been in private practice there since then. He completed a 3 year implant residency at Loma Linda School of Dentistry in 2000. He is an Honored Fellow of the American Academy of Implant Dentistry and a Diplomate of the American Board of Oral Implantology/Implant Dentistry. Dr. Elliott was a named plaintiff in a Federal lawsuit against the Texas Board of Dental Examiners for the right to claim specialty status in Implant Dentistry. The court found in favor of the plaintiffs by summary judgement in January 2016.. He is also the director of TexMAX® the newest AAID sponsored MaxiCourse® for implant education in the world.. ...
Differences in beliefs may also exist about the challenges of doing no harm. "First, do no harm" is a constant reminder to physicians. In 2006 the American Psychiatric Association voted overwhelmingly to discourage its members from participating in devising strategies to get information from detainees. When the Pentagon announced it would try to use only psychologists in this role, Stephen Behnke, director of ethics for the American Psychological Association, said "psychologists knew not to participate in activities that harmed detainees."[14] The president of the American Psychological Association in 2007 wrote: "The associations position is rooted in our belief that having psychologists consult with interrogation teams makes an important contribution toward keeping interrogations safe and ethical."[15]. It seems worth examining these assurances in light of increasingly detailed reports about detainee interrogations. Eban reported, "Psychologists werent merely complicit in Americas ...
Were these detainees arrested locally? Where did those that ended up being transferred from the Citrus County Jail last year originate? Information on the place of arrest was not included in the available data ICE released. However, we can examine whether the Citrus County Jail was the first ICE facility in which these detainees were held. According to ICE records, for a substantial proportion (33 percent) of these detainees, the Citrus County Jail was the first place they were sent when they were detained by ICE. The remaining 67 percent had been transferred in from another ICE detention facility. We can also look at how quickly they arrived at this facility after they were first detained. A total of 34 percent arrived at the Citrus County Jail at some point during the very first day they were detained by ICE. This percentage is also based on an analysis of the most recent 12 months for which data are available. How soon did transfers occur? Nationally, the median number of days before an ICE ...
If you wake up to ABCs Good Morning America, you may remember a recent story featuring UCLA urologist Jennifer Berman, MD, a frequent contributor on the "Healthy Woman" segment. This time, Berman herself was the subject.. "Dr. Jennifer Berman has a request that strikes at the heart of a controversy," Diane Sawyer explained as video footage showed Bermans five-month prenatal visit to her Ob/Gyn. "What shes about to ask for is an elective C-section. She wants to have her baby surgically, and shes doing it, she says, because of her first childbirth experience and because the problems she sees in her patients after they have vaginal births.". This is a story were likely to encounter more often. Elective C-sections (also called C-section on demand) are, in part, behind the skyrocketing Cesarean-section birth rate in the United States. This comes after a decade of emphasis on suppressing unnecessary C-section births, a school of medical thinking that the managed care industry wholeheartedly ...
If you wake up to ABCs Good Morning America, you may remember a recent story featuring UCLA urologist Jennifer Berman, MD, a frequent contributor on the "Healthy Woman" segment. This time, Berman herself was the subject.. "Dr. Jennifer Berman has a request that strikes at the heart of a controversy," Diane Sawyer explained as video footage showed Bermans five-month prenatal visit to her Ob/Gyn. "What shes about to ask for is an elective C-section. She wants to have her baby surgically, and shes doing it, she says, because of her first childbirth experience and because the problems she sees in her patients after they have vaginal births.". This is a story were likely to encounter more often. Elective C-sections (also called C-section on demand) are, in part, behind the skyrocketing Cesarean-section birth rate in the United States. This comes after a decade of emphasis on suppressing unnecessary C-section births, a school of medical thinking that the managed care industry wholeheartedly ...

EFFICIENT DIFFERENTIATION OF FUNCTIONAL DOPAMINERGIC NEURONS FROM HESCS FOR PARKINSONS DISEASE | ScholarBank@NUSEFFICIENT DIFFERENTIATION OF FUNCTIONAL DOPAMINERGIC NEURONS FROM HESCS FOR PARKINSON'S DISEASE | [email protected]

Donor fetal tissue transplantation showed promise in addressing some of the symptoms of PD. Derivation of dopaminergic cells ... Dopaminergic cells are derived from SOX- floor plate (FP) cells during embryonic development in many species and in human cell ... Due to the complex origin of FP cells, we hypothesized a SHH free approach in deriving SOX1- FP cells from hESCs in vitro. ... However, when the same patterning factors were applied to SOX1+ cells, only less than 4% of the cells are Nurr1+, indicating ...
more infohttp://scholarbank.nus.edu.sg/handle/10635/52259

Functional Analysis of Serially Expanded Human iPS Cell-Derived RPE Cultures | IOVS | ARVO JournalsFunctional Analysis of Serially Expanded Human iPS Cell-Derived RPE Cultures | IOVS | ARVO Journals

Although human fetal RPE (hfRPE) derived from donor tissue remains the culture standard, patient-specific, human-induced ... Pluripotent human stem cells for the treatment of retinal disease. J Cell Physiol . 2012; 227: 457-466. [CrossRef] [PubMed] ... Carr AJ Vugler AA Hikita ST Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the ... S2) found in neuroretinal cells, which frequently develop adjacent to RPE in human pluripotent stem cell cultures. 11 Similar ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2202986

Publications | Columbia Center for Translational ImmunologyPublications | Columbia Center for Translational Immunology

American Journal of Transplantation, 2014 Jan 14(1): 49-58. doi: 10.1111/ajt.12525. PMID: 24304495. PMCID: PMC4045013. ... Allospecific rejection of MHC class I-deficient bone marrow by CD8 T cells. ... human lymphoid and hematopoietic systems through human hematopoietic stem cell and human fetal thymic tissue transplantation ( ... MHC class I expression by donor hematopoietic stem cells is required to prevent NK cell attack in allogeneic, but not syngeneic ...
more infohttp://www.cumc.columbia.edu/ccti/research/publications

Patent US6793677 - Method of providing cells and other biologic materials for transplantation - Google PatentsPatent US6793677 - Method of providing cells and other biologic materials for transplantation - Google Patents

... and is applicable as well to other types of biologic tissues and materials such pancreas cells, cartilage cells, and so forth. ... Although the description makes specific reference to human disc cells, the invention may be used as a way to provide disease- ... In the preferred embodiment, the donor nucleus is morselized to allow insertion through a small puncture in the annulus ... In one disclosed example, living nucleus pulposis cells obtained from recently deceased human or animal donors are used to ...
more infohttp://www.google.com.au/patents/US6793677

Human hepatic stem cells from fetal and postnatal donors | JEMHuman hepatic stem cells from fetal and postnatal donors | JEM

EpCAM+ cells and colonies of hHpSCs give rise to human liver tissue in vivo. Transplantation of freshly isolated EpCAM+ cells ... Flow cytometry of EpCAM+ cells. Using flow cytometry, we observed EpCAM+ cells in human liver cell suspensions of all donor ... Transplantation of EpCAM+ cells (or colonies of stem cells in culture) results in engrafted liver tissue in NOD/scid mice. NOD/ ... Surface protein characterization of human adipose tissue-derived stromal cells. J. Cell. Physiol. 189:54-63. ...
more infohttp://jem.rupress.org/content/204/8/1973

Novartis receives European Commission approval of its CAR-T cell therapy, Kymriah® (tisagenlecleucel) | NovartisNovartis receives European Commission approval of its CAR-T cell therapy, Kymriah® (tisagenlecleucel) | Novartis

... tissue and cell donation: Patients treated with Kymriah should not donate blood, organs, tissues and cells for transplantation. ... It is unknown, whether Kymriah is excreted in human milk. A risk to the breast-fed infant cannot be excluded. Women, who are ... whether Kymriah has the potential to be transferred to the fetus via the placenta and could cause fetal toxicity, including B- ... Prolonged cytopenias, which is a low count of one or more types of blood cells such as red blood cells, white blood cells, or ...
more infohttps://www.novartis.com/news/media-releases/novartis-receives-european-commission-approval-its-car-t-cell-therapy-kymriah-tisagenlecleucel

Myocyte Enhancer Factor 2C as a Neurogenic and Antiapoptotic Transcription Factor in Murine Embryonic Stem Cells | Journal of...Myocyte Enhancer Factor 2C as a Neurogenic and Antiapoptotic Transcription Factor in Murine Embryonic Stem Cells | Journal of...

... the neural progenitor cell is likely to be a promising source of donor cells for brain transplantation. Embryonic stem cell ... but ethical considerations and a short supply of human fetal tissue limit this approach. Self-renewing and multipotent neural ... 2007) Bcl-X(L) modulates the differentiation of immortalized human neural stem cells. Cell Death Differ 14:1880-1892. ... 1999) Neural stem cells in the adult human brain. Exp Cell Res 253:733-736. ...
more infohttp://www.jneurosci.org/content/28/26/6557.long

Cord Blood Banking: Ethics of Stem Cell ResearchCord Blood Banking: Ethics of Stem Cell Research

... and in particular human embryonic stem cell research, is so controversial and discover why cord blood banking is a popular ... Learn about the ethics of stem cell research and find out why the stem cell research debate, ... embryonic stem cells are a highly effective source of transplant tissue sources. Embryonic stem cells are derived from embryos ... In this process, an embryo is created for a specific purpose; that is, for the generation of tissue used for transplantation, ...
more infohttps://www.wdxcyber.com/stem_cell_ethics.html

Written Testimony of Tara Sander Lee, Ph.D., in Support of Texas Bill to Prohibit Human Fetal Tissue Research | Charlotte...Written Testimony of Tara Sander Lee, Ph.D., in Support of Texas Bill to Prohibit Human Fetal Tissue Research | Charlotte...

Human fetal tissue from spontaneous abortion as potential sources of donor tissue for cell transplantation therapies. ... but not one person is alive today because of stem cells from aborted fetal tissue. Texas is at the forefront of adult stem cell ... Restricting the use of aborted fetal tissue will not bring research and clinical trials to a halt. Fetal tissue is making a ... and various leftover tissues from surgeries.[7] Human cadavers are another valuable tissue source, in which stem cells can be ...
more infohttps://lozierinstitute.org/written-testimony-of-tara-sander-lee-ph-d-in-support-of-texas-bill-to-prohibit-human-fetal-tissue-research/

Clinical Relevance of Natural Killer Cells Following Hematopoietic Stem Cell TransplantationClinical Relevance of Natural Killer Cells Following Hematopoietic Stem Cell Transplantation

Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. ... Donor-derived bone marrow contains stems cells, immune cells including immature and mature NK cells. Mature NK cells recognize ... NK-cell education is shaped by donor HLA genotype after unrelated allogeneic hematopoietic stem cell transplantation. Blood. ... Donor-derived NK cell maturation.... Allogeneic bone marrow.... NK cells play a vital role in.... NK cells as potential ...
more infohttp://www.jcancer.org/v04p0025.htm

Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork...Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork...

Human TM primary cells were cultured from TM tissue isolated from donor corneal rings used for corneal transplantation at the ... fetal bovine serum (FBS), penicillin (100 U/ml)-streptomycin (100 μg/ml) and glutamine (4 mM). All TM cell culture experiments ... the expected size from primary TM cell cultures derived from multiple human donor specimens and two independent human TM tissue ... Growth differentiation factor-15 increases the levels of αSMA and fibronectin in human TM cells. (A) Human TM cells were grown ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2589951

Molecular Vision: Pro370Leu mutant myocilin impairs
mitochondrial functions in human trabecular meshwork cellsMolecular Vision: Pro370Leu mutant myocilin impairs mitochondrial functions in human trabecular meshwork cells

Tissue procurement and cell culture. Procurement of the human tissue was performed according to the tenets of the Declaration ... Normal TM cells were derived from 5 human donor eyes with no known ocular diseases. These eyes were obtained within 24 h after ... Lin S, Lee OT, Minasi P, Wong J. Isolation, Culture, and Characterization of Human Fetal Trabecular Meshwork Cells. Curr Eye ... death and were dedicated for corneal transplantation. The ages of the donors ranged from 20 to 40 years. ...
more infohttp://www.molvis.org/molvis/v15/a84/

Characterization of Porcine Ventral Mesencephalic Precursor Cells following Long-Term Propagation in 3D CultureCharacterization of Porcine Ventral Mesencephalic Precursor Cells following Long-Term Propagation in 3D Culture

... and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and ... Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... Due to the limited availability of human fetal VM tissue, the pig has been suggested as a nonprimate donor of VM tissue ... and human fetal VM tissue 6.5-9 weeks of age is considered optimal for transplantation in PD [42, 43]. At 28 days of age, the ...
more infohttps://www.hindawi.com/journals/sci/2012/761843/

Demyelination and Remyelination | The New York Academy of SciencesDemyelination and Remyelination | The New York Academy of Sciences

... cells. Initial results suggest iPS cells may be more efficacious than fetal tissue.. Myelin development, disease, and cell- ... Glial progenitor cell transplantation could restore myelin in people with progressive MS.*Neural stem cell transplantation ... to 22-week-old human fetal tissue could myelinate and migrate in animal models. Transplanting these cells into several CNS ... producing extensive donor-derived myelination and restoring a normal lifespan.. However, myelination occurred slowly, over nine ...
more infohttps://www.nyas.org/ebriefings/demyelination-and-remyelination/

Adventitial Fibroblasts | Thermo Fisher Scientific - CAAdventitial Fibroblasts | Thermo Fisher Scientific - CA

Human. A small part of the horacic aorta was dissected from human donor and recipient hearts during heart transplantation. The ... Every Step of the Way, a Wide Range of Cell Health Products. Maintaining healthy cells is the key to experimental success and ... fetal bovine serum.. ... Tissues. Aorta. Phenotype. Adherent. Primary. yes. Application ... weve highlighted the technologies and products within cell biology that are critical to maintaining optimal cell health. No ...
more infohttps://www.thermofisher.com/ca/en/home/technical-resources/cell-lines/a/cell-lines-detail-551.html

Limbal Stem Cell Deficiency: Current Treatment Options and Emerging TherapiesLimbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies

... and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and ... Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... "Value of human amniotic epithelial cells in tissue engineering for cornea," Human Cell, vol. 23, no. 4, pp. 141-151, 2010. View ... living-related allogeneic cultivated limbal epithelium after hematopoietic stem cell transplantation from the same donor," ...
more infohttps://www.hindawi.com/journals/sci/2016/9798374/

More Tooth, More Tail in CRISPR Operations | GENMore Tooth, More Tail in CRISPR Operations | GEN

It offers the prospect of an unlimited supply of organs and cells, and it could resolve the critical shortage of human tissues. ... of studies show that patients who have sickle-cell or beta-thalassemia traits are asymptomatic when they have upregulated fetal ... Some approaches attempt to impact the level of cycling of the cells; others utilize modifications of the donor template and ... Cross-Species Transplantation. One application benefiting from CRISPR/Cas9 technology is xenotransplantation, or cross-species ...
more infohttps://www.genengnews.com/gen-articles/more-tooth-more-tail-in-crispr-operations/6019

Written Testimony on Bioethics and Fetal Tissue Submitted to the U.S. House of Representatives | The Center for Bioethics &...Written Testimony on "Bioethics and Fetal Tissue" Submitted to the U.S. House of Representatives | The Center for Bioethics &...

HOUSE OF REPRESENTATIVES regarding the ethics of fetal tissue use in research. ... Human Dignity submitted the following testimony on March 2, 2016 to the SELECT INVESTIGATIVE PANEL OF THE COMMITTEE ON ENERGY ... 42] Tetsuya Ishii and Koji Eto, "Fetal Stem Cell Transplantation: Past, Present, and Future," in World Journal of Stem Cells 6 ... ethically-derived source of cells, "which can be produced from tissue of any human being, without harm to the individual donor ...
more infohttps://cbhd.org/testimony-bioethics-and-fetal-tissue

Newly-Discovered Corneal Stem Cells Could Be a Potential Source for Treatment of Retinal Disease - VisionAware Blog -...Newly-Discovered Corneal Stem Cells Could Be a Potential Source for Treatment of Retinal Disease - VisionAware Blog -...

Autologous: Cells or tissues derived from the same individual; one individual is both donor and recipient. ... Identifying practical cell sources to generate sufficient functional cells for transplantation remains challenging, however. ... Human clinical trials using corneal stem cells will likely not begin until 2019 or 2020, at minimum. ... Utilizing embryonic or fetal tissue is difficult due to limited resources, ethical issues, or risks of tumor formation. In ...
more infohttps://www.visionaware.org/blog/visionaware-blog/newly-discovered-corneal-stem-cells-could-be-a-potential-source-for-treatment-of-retinal-disease/12

Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells | PNASCell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells | PNAS

PDX-1 Activates the Insulin Promoter in Human Liver Cells. Human liver cells were isolated from both adult and fetal tissues. ... Human Liver Cells. Adult human liver (AHL) tissues were obtained from eight different liver transplantation surgeries from 4- ... of a cell-replacement therapy for diabetics by allowing the patient to be the donor of his own insulin-producing tissue. ... Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells. Tamar Sapir ...
more infohttps://www.pnas.org/content/102/22/7964?ijkey=2aaf2ab978a4ec68d3b77542d26eeb1843cede87&keytype2=tf_ipsecsha

Cell Transplantation 20(4) AbstractsCell Transplantation 20(4) Abstracts

... brain cells represent a feasible and more readily available source of human fetal tissue for experimental cell transplantation ... but only using donor cells collected from fetal brain tissue obtained from surgical terminations of pregnancy. Surgical ... Key words: Human fetal tissue; Neural transplantation. 1These authors are joint first authors.. Address correspondence to ... Key words: Human islets; Human amniotic epithelial cells; Immune privilege; Rotational cell culture system; Peripheral blood ...
more infohttps://www.cognizantcommunication.com/component/content/article/398

10. Assessing Human Stem Cell Safety | stemcells.nih.gov10. Assessing Human Stem Cell Safety | stemcells.nih.gov

Safety Assurance Begins with Adequate Donor Screening. Whether human stem cells are of embryonic, fetal, or adult origin, donor ... Human stem cells must be transplanted into animal models of human disease. Transplantation of neural stem cells should ... Human stem cells from virtually every source other than blood-derived hematopoietic stem cells are maintained in tissue culture ... Assessing Human Stem Cell Safety. Back to top 10. Assessing Human Stem Cell Safety. The isolation of human stem cells offers ...
more infohttps://stemcells.nih.gov/node/110

Human hepatic stem cells from fetal and postnatal donors  | Journal of Experimental Medicine | Rockefeller University PressHuman hepatic stem cells from fetal and postnatal donors | Journal of Experimental Medicine | Rockefeller University Press

EpCAM+ cells and colonies of hHpSCs give rise to human liver tissue in vivo Transplantation of freshly isolated EpCAM+ cells or ... Flow cytometry of EpCAM+ cells Using flow cytometry, we observed EpCAM+ cells in human liver cell suspensions of all donor ages ... Transplantation of EpCAM+ cells (or colonies of stem cells in culture) results in engrafted liver tissue in NOD/scid mice. NOD/ ... Transplantation of EpCAM+ cells (or colonies of stem cells in culture) results in engrafted liver tissue in NOD/scid mice. NOD/ ...
more infohttps://rupress.org/jem/article/204/8/1973/46991/Human-hepatic-stem-cells-from-fetal-and-postnatal

Transplantation of dopamine-synthesizing cells-new therapy for Parkinsons disease? | Springer for Research & DevelopmentTransplantation of dopamine-synthesizing cells-new therapy for Parkinson's disease? | Springer for Research & Development

In the future, catecholamine-synthesizing cell lines may provide a valid alternative to presently considered donor tissue. ... Kamo H, Kim SU, McGeer PL, Shin DH (1985) Transplantation of cultured fetal human adrenal chromaffin cells to rat brain. ... Human fetal adrenal medullary cells reduce experimental parkinsonism in monkey. In: Gash DM, Sladek JR Jr (eds) Transplantation ... Human fetal chromaffin cells for neurotransplantation in parkinsonian patients. In: Gash DM, Sladek JR Jr (eds) Transplantation ...
more infohttps://rd.springer.com/chapter/10.1007/978-3-7091-8994-8_34

Evaluation of PLGA Nanoparticles Carrying Leukaemia Inhibitory Factor for Stromal-Like Support of Rat Fetal Dopaminergic Cells ...Evaluation of PLGA Nanoparticles Carrying Leukaemia Inhibitory Factor for Stromal-Like Support of Rat Fetal Dopaminergic Cells ...

Evaluation of PLGA Nanoparticles Carrying Leukaemia Inhibitory Factor for Stromal-Like Support of Rat Fetal Dopaminergic Cells ... a current clinical source of dopaminergic cells for transplantation is from donated primary human fetal tissue, subject to full ... After a single cell suspension was prepared, the fetal VM-derived cells were collected as a crude concentrated cell suspension ... As an alternative to hfVM, in the future donor DA cells may be derived from human embryonic stem cells; or from ...
more infohttps://www.scitechnol.com/peer-review/evaluation-of-plga-nanoparticles-carrying-leukaemia-inhibitory-factor-for-stromallike-support-of-rat-fetal-dopaminergic-cells-8UsL.php?article_id=2170
  • Here, using a constitutively active form of MEF2C (MEF2CA), we report the production and characterization of neuronally restricted progenitors derived from non-oncogene-transformed, murine embryonic stem (ES) cells, and their subsequent successful transplantation into a disease model of focal cerebral ischemia. (jneurosci.org)
  • Despite the great successes of CLET, there still is room for improvement as overall success rate is 70% and visual acuity often remains suboptimal after successful transplantation. (hindawi.com)
  • Nonetheless, in 1997, pig-to-human transplants were banned worldwide due to concerns about the transmission to humans of porcine endogenous retroviruses (PERVs), which are integrated into the genome of all pigs. (genengnews.com)
  • While these transplants could survive and function for many years, there were scientific and ethical issues: fetal cells are in limited supply, and they are highly variable and hard to quality control. (alternative-medicine-doctors.com)
  • They are negative for α-fetoprotein (AFP), intercellular adhesion molecule (ICAM) 1, and for markers of adult liver cells (cytochrome P450s), hemopoietic cells (CD45), and mesenchymal cells (vascular endothelial growth factor receptor and desmin). (rupress.org)
  • Before they are transplanted, cultured human stem cells are maintained under conditions that promote either the self-renewing expansion of undifferentiated progenitors or the acquisition of differentiated properties indicative of the phenotype the cells will assume. (nih.gov)
  • The role of human hepatic stem cells (hHpSCs), particularly in the maintenance and regeneration of the adult liver, has been a subject of debate without a clear consensus ( 1 - 11 ). (rupress.org)
  • State-of-the-art therapeutic management of LSCD is described, and new and evolving techniques in ocular surface regeneration are being discussed, in particular, advantages and disadvantages of alternative cell scaffolds and cell sources for cell based ocular surface reconstruction. (hindawi.com)
  • Transplantation, 2016. (columbia.edu)
  • Editor's Note: Paige Cunningham, Executive Director of The Center for Bioethics & Human Dignity submitted the following testimony on March 2, 2016 to the SELECT INVESTIGATIVE PANEL OF THE COMMITTEE ON ENERGY AND COMMERCE U. S. HOUSE OF REPRESENTATIVES regarding the ethics of fetal tissue use in research. (cbhd.org)
  • Palmer JM, Rajasekaran K, Thakar MS, Malarkannan S. Clinical Relevance of Natural Killer Cells Following Hematopoietic Stem Cell Transplantation. (jcancer.org)
  • Clinical studies involving the transplantation of blood-restoring, or hematopoietic, stem cells have been under way for a number of years. (nih.gov)
  • Moreover, clinical trials are being conducted to assess the safety and efficacy of using hematopoietic stem cell transplantation to treat various autoimmune conditions including multiple sclerosis, lupus, and rheumatoid arthritis. (nih.gov)
  • This hesitancy extends to adult human stem cells of non-hematopoietic origin, even though, by contrast, their plasticity is generally considered to be lower than that of their embryo- and fetus-derived counterparts. (nih.gov)
  • The FDA has approved five hematopoietic stem-cell products derived from umbilical cord blood, for the treatment of blood and immunological diseases. (wikipedia.org)
  • In one disclosed example, living nucleus pulposis cells obtained from recently deceased human or animal donors are used to restore disc function and eliminate pain in patients with disc disease. (google.com.au)
  • Shortage in tissue availability from cadaver donors and the need for life-long immunosuppression severely restrict the large-scale application of cell-replacement therapy for diabetic patients. (pnas.org)
  • Some were made with iPS cells from healthy donors. (laboratoryequipment.com)
  • MEF2 proteins are highly expressed in cardiac myocytes and induce myogenesis from precursor cells ( Black and Olson, 1998 ). (jneurosci.org)
  • Usually cultures of neural precursor cells are established by initial mechanical or enzymatic dissociation as well as enzymatic dissociation during cell passaging. (hindawi.com)
  • In order to avoid mechanical and enzymatic dissociation and to preserve an organotypic intercellular microenvironment during propagation of neural precursor cells, culturing of tissue microexplants as neural tissue spheres (NTS) was established in our laboratory [ 19 , 20 ]. (hindawi.com)
  • Anderson DJ, Axel R (1986) A bipotential neuroendocrine precursor whose choice of cell fate is determined by NGF and glucocorticoids. (springer.com)
  • Here, we investigated the mechanisms for Pro370Leu mutant myocilin to induce mitochondrial dysfunction and subsequent reactive oxygen species (ROS) generation in trabecular meshwork (TM) cells obtained from POAG individuals. (molvis.org)
  • Pharmacological activation of endogenous neural stem cells has been reported to induce neuroprotection and behavioral recovery in adult rat models of neurological disorder. (wikipedia.org)
  • Stimulation of human TM cells with rGDF-15 caused a significant increase in the formation of actin stress fibers and focal adhesions, myosin light chain phosphorylation, SMAD signaling, gene expression, and the levels of αSMA and ECM proteins. (arvojournals.org)
  • The results of this study, including a robust induction of GDF-15 expression by several external factors known to elevate IOP, and rGDF-15-induced increase in contractility, cell adhesion, and the levels of ECM proteins and αSMA in TM cells, collectively suggest a potential role for GDF-15 in homeostasis and dysregulation of AH outflow and IOP in normal and glaucomatous eyes, respectively. (arvojournals.org)
  • The benefits of stem cells include the potential treatment and cures of serious illnesses through transplantation, including spinal cord injury, heart disease, Alzheimer's disease, arthritis, diabetes and stroke. (wdxcyber.com)
  • Scientists that use aborted fetal tissue claim that they "need" these tissues, because they provide the "best option" for studying devastating diseases such as Alzheimer's and spinal cord injury. (lozierinstitute.org)
  • And none of the grants or clinical trials on Alzheimer's use fetal tissue, which is often falsely stated as being "required" for this field. (lozierinstitute.org)
  • The capabilities to self-renew and differentiate that are inherent to human stem cells point simultaneously to their perceived therapeutic potential and to the challenge of assessing their safety. (nih.gov)
  • In this paradigm multipotent or unipotent cells differentiate into a specific cell type in the lab or after reaching the site of injury (via local or systemic administration). (wikipedia.org)
  • Known as somatic cell nuclear transfer, this process is highly controversial due to both medical and ethical concerns and is illegal in the United States, the United Kingdom and Australia, where any research involving human cloning is prohibited. (wdxcyber.com)
  • These OVA-specific antibodies displayed the highest frequency of somatic mutation, further suggesting that human IL-6 is important for efficient B-cell activation and selection. (bloodjournal.org)
  • Kalscheuer H, Onoe T, Dahmani A, Holzl M, Yamada K, Sykes M. Xenograft tolerance and immune function of human T cells developing in pig thymus xenografts . (columbia.edu)
  • However, recent research has shown that some adult cells may be able to generate different types of tissues under appropriate conditions in order to increase their medical potential. (wdxcyber.com)
  • Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition leading to decreased visual acuity, photophobia, and ocular pain. (hindawi.com)
  • Damage to the stem cells or disruption of the niches may lead to Limbal Stem Cell Deficiency (LSCD). (hindawi.com)
  • In 2014, the European Medicines Agency recommended approval of limbal stem cells for people with severe limbal stem cell deficiency due to burns in the eye. (wikipedia.org)
  • A small part of the horacic aorta was dissected from human donor and recipient hearts during heart transplantation. (thermofisher.com)
  • one individual is both donor and recipient. (visionaware.org)
  • Transplanted human stem cells are dynamic biological entities that interact intimately with-and are influenced by-the physiology of the recipient. (nih.gov)
  • After incompletely differentiated human stem cells are transplanted, additional fine-tuning occurs as a consequence of instructions received from the cells' physiologic microenvironments within the recipient. (nih.gov)
  • 2. The method of claim 1 , further including the step of adding one or more therapeutic substances to the harvested cells or tissue. (google.com.au)
  • Chairman Blackburn and members of the Panel, thank you for inviting me to present my views, which are consistent with those of my employer The Center for Bioethics & Human Dignity on the bioethical issues involving the use of fetal tissue for research and therapeutic purposes. (cbhd.org)
  • Others argue that a good deal more information about the basic biology of human stem cells needs to be accumulated before their therapeutic potential in humans can be assessed. (nih.gov)
  • However, a critical step in this process is the survival and integration of the grafted dopaminergic neurons, and by virtue of the process involved in this therapeutic approach, the cells lack both stromal and growth factor support and are acutely vulnerable to ischaemic stress and an innate immune response: furthermore, endogenous immune tolerance needs to be guided to accept the graft as "self" if rejection is to be avoided. (scitechnol.com)
  • This includes cells that naturally secrete the relevant therapeutic factors, or which undergo epigenetic changes or genetic engineering that causes the cells to release large quantities of a specific molecule. (wikipedia.org)
  • Derivation of dopaminergic cells from human embryonic stem cells (hESCs) could provide new options for PD therapy. (nus.edu.sg)
  • However, low availability of human foetal tissue, ethical concerns related to its procurement and use, limited survival and integration of the grafted dopaminergic neurons, and the highly variable developmental stage of the donor tissue have restricted the clinical application [ 5 ]. (hindawi.com)
  • Dyson S, Fahmy TM, Metcalfe SM, Barker RA (2014) Evaluation of PLGA Nanoparticles Carrying Leukaemia Inhibitory Factor for Stromal-Like Support of Rat Fetal Dopaminergic Cells. (scitechnol.com)
  • New cell-based treatments for PD aim to reintroduce healthy dopaminergic (DA) cells to replace the lost dopaminergic input to the striatum which underlies many of the motor, and some of the cognitive, features of this disease. (scitechnol.com)
  • In this paper we show that creating a transient surrogate stroma composed of PLGA nanoparticles able to deliver a cargo of the reparative, tolerogenic cytokine leukaemia inhibitory factor (LIF) directly to DA cells is able to improve dopaminergic cell survival. (scitechnol.com)
  • During embryonic development, endodermal cells in the mid-region of the embryo bulge into the cardiac mesenchyme, are affected by critical signaling from endothelia forming vasculature, and form the liver bud ( 6 , 7 ). (rupress.org)
  • observed that hepatoblasts in embryonic human liver are EpCAM+, whereas mature hepatocytes are EpCAM− ( 15 ). (rupress.org)
  • We have previously reported that EpCAM+, AFP− cells from human livers are hHpSCs, and we have compared their pattern of gene expression with that of hepatoblasts and mature liver parenchyma ( 17 ). (rupress.org)
  • PDX-1-treated human liver cells express insulin, store it in defined granules, and secrete the hormone in a glucose-regulated manner. (pnas.org)
  • Inducing developmental redirection of adult liver offers the potential of a cell-replacement therapy for diabetics by allowing the patient to be the donor of his own insulin-producing tissue. (pnas.org)
  • Up to 50% of the liver cells that expressed the PDX-1 transgene activated the otherwise inactive insulin promoter. (pnas.org)
  • PDX-1 induced transdifferentiated human liver cells produced the hormone, stored it in granules, and released processed insulin in a glucose-regulated manner. (pnas.org)
  • This study suggests that adult liver could be considered as a pancreatic progenitor tissue. (pnas.org)
  • ADAR1 and ADAR2 manipulate the A to I imbalance of HCC via their differential expression in HCC compared with NT liver tissues. (bmj.com)
  • The cells that attached were cultured in DMEM, supplemented with L-glutamine, 100 U/mL penicillin, 100 ug/mL streptomycin, and 10% fetal bovine serum. (thermofisher.com)
  • Human IL-6 improves T-cell engraftment and serum IgG production in humanized mice. (bloodjournal.org)
  • The provision of human IL-6 not only enhanced thymopoiesis and periphery T-cell engraftment, but also significantly increased class switched memory B cells and serum immunoglobulin G (IgG). (bloodjournal.org)
  • For ethical and compatibility reasons, xenotransplantation shifted away from nonhuman primates as a potential source of donor tissues. (genengnews.com)
  • Issues such as method of application, target areas and long term immunological graft-host reaction await further research in non-human primates. (springer.com)
  • Bakay RAE, Sweeney KM, Colbassani HJ, Collins DC (1988) Delayed stereo-tactic transplantation technique in primates. (springer.com)
  • The delivered cells (via local or systemic administration) remain viable for a relatively short period (days-weeks) and then die. (wikipedia.org)
  • Rather than being a distinct-and lesser-form of human life, the fetus is a distinct human being at a particular developmental stage. (cbhd.org)
  • Included in this global assessment are the derivation, expansion, manipulation, and characterization of human stem cell lines, as well as preclinical efficacy and toxicity testing in appropriate animal models. (nih.gov)
  • In: Gash DM, SladekJRJr (eds) Transplantation into the mammalian CNS: preclinical and clinical studies. (springer.com)