Cell Dedifferentiation

Cell Differentiation

Cellular differentiation

Glossary of genetics (0-L)

Glossary of genetics

Dedifferentiation

Cell fate determination

Pluripotency (biological compounds)

Transdifferentiation

Reversine

Interleukin 4

Betty Hay

Induced stem cells

Cell potency

Air-liquid interface cell culture

Plant stem cell

Polycomb-group proteins

Oncostatin M receptor

ENOD40

Minusheet perfusion culture system

Endogenous regeneration

Owen Sansom

Retinal regeneration

Chiridotidae

TYRP1

Rho kinase inhibitor

Aspirin exacerbated respiratory disease

Forkhead box protein O1

Rex1

Oct-4

2,4-Dichlorophenoxyacetic acid

Stem cell marker

Thomas Tüting

Directed differentiation

Callus (cell biology)

Müller glia

Anaplasia

Haematopoiesis

Sic1

Desmoplasia

Wallerian degeneration

Invasion (cancer)

Sangeeta N. Bhatia

Blastema

Agent-based model in biology

Cancer stem cell

Neoplasm

GDF11

Proliferation12

• It particular, Wnt signaling positively regulates cardiomyocyte dedifferentiation and proliferation. (uni-ulm.de)
• Knockout of PHF20 inhibits GBM cell proliferation, as well as its invasiveness and stem cell-like traits. (frontiersin.org)
• As such, elucidating the mechanism of GBM stem cell (GSC) proliferation and maintenance is critical to improve our understanding of the development of GBM. (frontiersin.org)
• It is characterized by uncontrolled proliferation of lymphoid lineage cells (typically B cells, rarely non-B lineage) in a context of posttransplant immunosuppression. (medscape.com)
• The invention relates to methods and compositions for identifying subjects having, or predisposed to having, a neoplastic or cell proliferation or neoplastic disorder. (justia.com)
• Currently, no single biochemical marker, or plurality of biochemical markers, reliably identifies a subject at risk for developing a disease associated with LOI and/or uncontrolled cell proliferation or neoplastic disorders (e.g., benign and cancer). (justia.com)
• Thus, there exists a need for diagnostic methods and compositions that can utilize cell differentiation information to identify those individuals at risk for developing a cell proliferation or neoplastic disorder. (justia.com)
• The present invention is based on the discovery that alterations in ratios of differentiated and undifferentiated cell populations can be used as early indicators for the risk of developing cell proliferation or neoplastic disorders. (justia.com)
• I have studied the transcription factor Krox-20 and how this protein co-ordinates the proliferation, survival and myelination of Schwann cells. (plymouth.ac.uk)
• Neuroblastoma and other cancers occur when a buildup of genetic mutations in critical genes-those that control cell growth and division (proliferation) or maturation (differentiation)-allow cells to grow and divide uncontrollably to form a tumor. (medlineplus.gov)
• Although the specific function of this protein is unknown, it appears to play an important role in cell proliferation. (medlineplus.gov)
• Constitutively active ALK receptor tyrosine kinase may induce abnormal proliferation of immature nerve cells and lead to neuroblastoma. (medlineplus.gov)

Spermatogonial dedifferentiation2

• Brawley, C & Matunis, E 2004, ' Regeneration of male germline stem cells by spermatogonial dedifferentiation in vivo ', Science , vol. 304, no. 5675, pp. 1331-1334. (northwestern.edu)
• Spermatogonial Dedifferentiation into Germline Stem Cells in Drosophila Testes. (bvsalud.org)

Differentiation14

• By conditionally manipulating Jak-STAT signaling, we find that spermatogonia that have initiated differentiation and are undergoing limited mitotic (transit-amplifying) divisions can repopulate the niche and revert to stem cell identity. (northwestern.edu)
• Our data demonstrates plasticity of leukemic cells under antigen-specific immune pressure, with de-differentiation and lineage switch. (nih.gov)
• The team discovered that McSC differentiation was triggered in the hair germ by molecular signals from nearby cells. (nih.gov)
• 2. The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development. (nih.gov)
• 12. MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31. (nih.gov)
• differentiation/dedifferentiation. (nih.gov)
• ref. 5 ), which demethylates histone H3 on Lys 4 or Lys 9 (H3K4/K9), is essential in decommissioning enhancers during the differentiation of mouse embryonic stem cells (ESCs). (nature.com)
• We propose that the LSD1-NuRD complex decommissions enhancers of the pluripotency program during differentiation, which is essential for the complete shutdown of the ESC gene expression program and the transition to new cell states. (nature.com)
• My research interest is focused on the mechanisms by which cell de-differentiation and cell identity are regulated. (nih.gov)
• Expression of SSEA-1 is down-regulated following differentiation of murine EC and ES cells. (rndsystems.com)
• In contrast, the differentiation of human EC and ES cells is accompanied by an increase in SSEA-1 expression (1, 2). (rndsystems.com)
• The PHOX2B gene is important for the formation and differentiation of nerve cells. (medlineplus.gov)
• Mutations in this gene are believed to interfere with the PHOX2B protein's role in promoting nerve cell differentiation. (medlineplus.gov)
• This disruption of differentiation results in an excess of immature nerve cells and leads to neuroblastoma. (medlineplus.gov)

Melanocyte stem cells2

• They arise from melanocyte stem cells (McSCs). (nih.gov)
• It is the loss of chameleon-like function in melanocyte stem cells that may be responsible for graying and loss of hair color," Ito says. (nih.gov)

Somatic cells1

• The second mechanism, called genomic imprinting, is an epigenetic modification of a specific parental chromosome in the gamete or zygote that leads to monoallelic or differential expression of the two alleles of a gene in somatic cells of the offspring. (justia.com)

Germline3

• germline stem cells lacking Jak-STAT signaling differentiate into spermatogonia without self-renewal. (northwestern.edu)
• The testis of the fruit fly Drosophila melanogaster offers a simple but powerful system to study dedifferentiation, the process by which differentiating spermatogonia can revert their fate to become fully functional germline stem cells (GSCs). (bvsalud.org)
• To facilitate the study of the cellular and molecular mechanisms underlying the process of germline dedifferentiation in the Drosophila testis , here we describe techniques for inducing high rates of dedifferentiation and for unambiguously labeling dedifferentiated GSCs. (bvsalud.org)

Lineage4

• These late relapses showed expression of cell surface markers compatible with a myeloid lineage (Gr1, Mac1), T cell or undifferentiated lineage (KIT, CD9), confirmed by RNA-sequencing. (nih.gov)
• Kidney injury molecule-1 (KIM-1 or TIM-1) is an immunoglobulin superfamily cell-surface protein not expressed by cells of the myeloid lineage but highly upregulated on the surface of injured kidney epithelial cells. (jci.org)
• My long-term research interest lies in understanding cellular specification and commitment during development of a cell lineage. (nih.gov)
• A reverse developmental process in which terminally differentiated cells with specialized functions revert back to a less differentiated stage within their own CELL LINEAGE . (nih.gov)

Tumor10

• Analyses of the tumor microenvironment revealed unanticipated correlation of cancer stemness with immune checkpoint expression and infiltrating immune cells. (nih.gov)
• Application of our stemness indices to single-cell data revealed patterns of intra-tumor molecular heterogeneity. (nih.gov)
• Glioblastoma (GBM) stem cells are resistant to cancer therapy, and therefore responsible for tumor progression and recurrence after conventional therapy. (frontiersin.org)
• Based on the similarities between somatic cellular reprogramming and cancer stem cells reprogramming, PHF20 plays an important role in carcinogenesis by dramatically enhancing the self-renewal and tumor-initiating capabilities of lung cancer cells, as well as controlling the stem cell-like phenotype of neuroblastoma cells ( 15 , 16 ). (frontiersin.org)
• Dr. Pan has been focusing on studying the mechanisms by which cancer evades immune responses in the tumor microenvironment (TME), more specifically the contribution of myeloid derived suppressor cells (MDSC) to tumor progression. (houstonmethodist.org)
• More recently, Dr. Pan identified a potential role of myeloid inhibitory receptors in the maintenance of tumor-initiating cells (TIC) and radio/chemo-resistance of colon cancer. (houstonmethodist.org)
• Current strategies to diminish GVHD include T-cell depletion and immunosuppressive drugs, which are associated with an increased risk of tumor relapse, opportunistic infection, and/or toxicity. (houstonmethodist.org)
• Smaller tumor cells are found in the cytoplasm of larger tumor cells with crescent-shaped nucleus. (who.int)
• Neuroblastoma occurs when immature nerve cells called neuroblasts become abnormal and multiply uncontrollably to form a tumor. (medlineplus.gov)
• Researchers believe the deleted regions in these chromosomes could contain a gene that keeps cells from growing and dividing too quickly or in an uncontrolled way, called a tumor suppressor gene. (medlineplus.gov)

Embryonic stem3

• The P01 should include a core to grow, maintain, and further characterize approved hESC lines listed on the NIH Human Embryonic Stem Cell Registry, http://stemcells.nih.gov/research/registry/ . (nih.gov)
• Young, R. A. Control of the embryonic stem cell state. (nature.com)
• SSEA‑1 was detected in immersion fixed D3 mouse embryonic stem cell line using 10 µg/mL Human/Mouse SSEA‑1 Monoclonal Antibody (Catalog # MAB2155) for 3 hours at room temperature. (rndsystems.com)

Becoming dedifferentiated1

• Our finding implies that activation of the GLP-1 receptor signaling may prevent β cells from becoming dedifferentiated by modulating Txnip and may slow diabetes progression in Wolfram syndrome. (diabetesjournals.org)

Vivo1

• We demonstrated that MDSCs induced antigen specific T regulatory cells and T-cell anergy in vivo. (houstonmethodist.org)

Stemness3

• Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation. (nih.gov)
• Here, we provide novel stemness indices for assessing the degree of oncogenic dedifferentiation. (nih.gov)
• However, the molecular mechanisms driving the maintenance of stemness and dedifferentiation are poorly understood. (frontiersin.org)

Biology9

• 1 The Ronald O. Perelman Department of Dermatology and Department of Cell Biology, New York University Grossman School of Medicine, New York, NY, USA. (nih.gov)
• 5 Black Family Stem Cell Institute, Department of Cell, Developmental and Regenerative Biology and Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. (nih.gov)
• The goal of the proposed Program Project (P01) grants is to support research on the basic biology of human embryonic stem cells (hESC) and to promote the use of hESC as a model system to address significant questions in the basic biomedical sciences. (nih.gov)
• The purpose of the workshop was to discuss and identify potential areas of the auditory and vestibular systems that might be good candidates for applications being used in other reparative medicine systems, one being the potential use of stem cell biology. (nih.gov)
• The workshop panel was composed of a diverse group of experts from auditory and vestibular systems as well as tissue engineers using aspects of stem cell biology in other reparative systems. (nih.gov)
• I received my PhD in stem cell biology from the Faculty of Medicine at The University of Helsinki, Finland. (nih.gov)
• Students will be trained in both the theoretical and practical aspects of stem cell biology. (ca.gov)
• Courses on stem cell biology, isolation and maintenance will ensure that the interns have the skill set to be successful and receive maximum benefit from their subsequent internship. (ca.gov)
• His laboratory has been studying the biology of melanoma and has made significant contributions to understanding stem cells as they relate to cancer. (medscape.com)

Phenotype2

• Cancer progression involves the gradual loss of a differentiated phenotype and acquisition of progenitor and stem-cell-like features. (nih.gov)
• In this study, we identified plant homeodomain finger-containing protein 20 (PHF20) as a crucial epigenetic regulator for sustaining the stem cell-like phenotype of GBM. (frontiersin.org)

Revert1

• We have so far evidenced that, in the Wfs1 -/- mice, β cells become dedifferentiated and revert to endocrine progenitor-like cells expressing Ngn3, and a subset of β cells takes α cell fate. (diabetesjournals.org)

Mechanisms8

• Although the ability of engrafted stem cells to regenerate tissue has received much attention, the molecular mechanisms controlling regeneration are poorly understood. (northwestern.edu)
• Those guys actually use a 'stem cell mediated method' of regenerating," says Catherine McCusker , a professor of molecular mechanisms of regeneration at University of Massachusetts, Boston. (discovermagazine.com)
• The mission of CBDS will be to better define and detect the mechanisms of beta cell stress and destruction central to the development of T1D in humans, with the long-term goal of protecting the residual beta cell mass in T1D patients as early as possible in the disease process. (nih.gov)
• During my PhD and as a postdoctoral fellow at National Eye Institute, I developed a strong interest in regenerative medicine studying the signals and mechanisms that control cell identity. (nih.gov)
• Currently, at Dr. Kerosuo's lab I am interested in the mechanisms that maintain the pluripotent state and the cell identity of the neural crest cells, and how these mechanisms could contribute to regenerative therapies and disease. (nih.gov)
• Precise understanding of the mechanisms that induce and maintain the pluripotency of the stem cell niche in neural crest cells is fundamental to model neural crest defects to develop regenerative therapeutic strategies. (nih.gov)
• The focus of my research is to harness the suppressive function of myeloid-derived suppressor cells (MDSCs) for the treatment/prevention of graft-versus-host diseases (GVHDs) and to study the mechanisms underlying the differential regulation of GVHD and graft-versus-leukemia/lymphoma (GVL) activities by myeloid-derived suppressor cells (MDSCs). (houstonmethodist.org)
• Myeloid-derived suppressor cells (MDSCs) suppress T-cell responses through multiple mechanisms. (houstonmethodist.org)

Induces1

• Here we show that chronic and low level of arsenic stress induces transformation of the human bronchial epithelial cells, BEAS-2B, and that some of the transformed cells show characteristics of cancer stem-like cells (CSCs). (nih.gov)

Progenitor cells5

• They produce progenitor cells that populate an area called the hair germ. (nih.gov)
• During hair growth, the progenitor cells differentiate (develop) into mature cells. (nih.gov)
• Existence of auditory and vestibular progenitor cells. (nih.gov)
• Identification of stem or progenitor cells that give rise to hair cells/supporting cells in embryos and adults (human). (nih.gov)
• Identification of new cell surface markers for progenitor cells using non-traditional probe generating techniques. (nih.gov)

Mesenchymal stem5

• 1. Reprogramming of mesenchymal stem cells by oncogenes. (nih.gov)
• 7. Reprogramming of Oncogene Expression in Gingival Mesenchymal Stem Cells Following Long-Term Culture In Vitro. (nih.gov)
• 9. Enhancing the efficiency of direct reprogramming of human mesenchymal stem cells into mature neuronal-like cells with the combination of small molecule modulators of chromatin modifying enzymes, SMAD signaling and cyclic adenosine monophosphate levels. (nih.gov)
• 10. A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells. (nih.gov)
• 16. Senescence bypass in mesenchymal stem cells: a potential pathogenesis and implications of pro-senescence therapy in sarcomas. (nih.gov)

Plasticity3

• Such β cell plasticity appears after nursing, independently of hyperglycaemia, and becomes more apparent along with diabetes progression accompanied with no significant increase in apoptosis. (diabetesjournals.org)
• In this study, we examined the potential effects of a GLP-1 receptor agonist on β cell plasticity and glucose homeostasis in young Wfs1 −/− mice without noticeable hyperglycaemia. (diabetesjournals.org)
• My lab also researches what underlies the remarkable ability of Schwann cells to regenerate and repair injury in the peripheral nervous system and how proteins such as c-Jun, Sox-2 and the Merlin tumour suppressor facilitate this repair and cell plasticity. (plymouth.ac.uk)

Epithelial Cells3

• Altogether, our findings highlight a unique mechanism of arsenic-induced transformation of human bronchial epithelial cells and provide a novel therapeutic target for arsenic-initiated lung cancer. (nih.gov)
• In addition to macrophages, which are traditionally assigned to this task, neighboring epithelial cells in the affected tissue are postulated to contribute to this process. (jci.org)
• Here we demonstrate that injured kidney epithelial cells assumed attributes of endogenous phagocytes. (jci.org)

Regenerate1

• When a big amputation happens, those cells are essentially called upon to regenerate the missing structure, no matter what it is. (discovermagazine.com)

Neural crest progenitor2

• Furthermore, I had the opportunity to be a part of a collaboration with biophysicists, which led to the development of Spatial Genomic Analysis, a single molecule fluorescent in situ hybridization (smFISH)-based multiplex transcriptome analysis that revealed a pluripotent stem cell niche embedded in the neural crest progenitor domain in the dorsal neural tube. (nih.gov)
• Harvard researchers have engineered zebrafish that can be used to visually track melanoma as it begins - from its initiation from neural crest progenitor (NCP)-like cells to full-blown melanoma. (medscape.com)

Gene3

• The team next took a closer look at the cells' structure and gene activity at different stages of hair growth. (nih.gov)
• The regenerative potential of two types of platelet-rich plasma (PRP), prepared in the presence of EDTA (EPRP) and citrate (CPRP) and an alternative blood product-hyperacute serum (hypACT) was evaluated using a 3D osteoarthritic chondrocyte pellet model by assessing the metabolic cell activity, cartilage-related gene expression and extracellular matrix deposition within the pellets. (mdpi.com)
• Each mammalian cell carries two copies of each gene, one inherited from the mother (on the maternal chromosome) and one inherited from the father (on the paternal chromosome). (justia.com)

Prevention1

• Furthermore, we have found that genetic ablation of Txnip in Wfs1 -/- mice inhibited β cell dedifferentiation, resulting in prevention of diabetes progression with preservation of β cell mass. (diabetesjournals.org)

Dedifferentiate3

• Thus, in the appropriate microenvironment, transit-amplifying cells dedifferentiate, becoming functional stem cells during tissue regeneration. (northwestern.edu)
• Even highly differentiated, pigment-producing McSCs could dedifferentiate into stem cells. (nih.gov)
• they do not use (only) stem cells, but mature osteoblasts, which dedifferentiate in respone to fractures. (uni-ulm.de)

Functional6

• Loss of functional β cells results in a gradual progression of insulin insufficiency in Wolfram syndrome caused by recessive WFS1 mutations. (diabetesjournals.org)
• In association with the functional improvements, Ex-4 alleviated β cell dedifferentiation evidenced by a decrease of MafA and a Ngn3 emergence. (diabetesjournals.org)
• Acceptance of other cell sources for functional integration, and identification of molecules and agents that impact this. (nih.gov)
• HIRN's overall mission will be to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. (nih.gov)
• Starting in 2014 NIDDK will establish a new team science program, the Human Islet Research Network (HIRN), to help organize and support collaborative translational research related to the loss of functional beta cell mass in Type 1 Diabetes (T1D). (nih.gov)
• HIRN will be jointly supported by NIDDK and the type 1 diabetes special funding program, and its overall mission will be to better understand how human beta cells are lost in T1D, and to find innovative strategies to protect or replace functional beta cell mass in diabetic patients. (nih.gov)

Senescence1

• Senescence of the immune system function could interfere with transmissible spongiform encephalopathy pathogenesis in other ways as well, such as impairing migrating intestinal dendritic cells or complement pathways involved in complexing PrP Res to follicular dendritic cells. (cdc.gov)

Pathway3

• Importantly, using Cre-lox technology we could show that the pathway acts cell-autonomously within cardiomyocytes. (uni-ulm.de)
• Defects in either the complement pathway or follicular dendritic cells result in resistance to peripheral scrapie infection ( 7 , 8 ), and this resistance likely occurs for peripheral transmissible spongiform encephalopathy infections in general. (cdc.gov)
• Working jointly in the Kerosuo and Werner labs, I have embarked upon an exciting scientific adventure identifying novel ubiquitination pathway components involved in craniofacial bone and cartilage formation from neural crest cells. (nih.gov)

Scholars1

• The Stem Cell Scholars from Basic Research to Clinical Translation training program has the following four components to ensure its success and provide a great benefit both to the students and the community that our campus serves. (ca.gov)

Epigenetic3

• 19. Pharmacological mimicking of caloric restriction elicits epigenetic reprogramming of differentiated cells to stem-like self-renewal states. (nih.gov)
• We used an innovative one-class logistic regression (OCLR) machine-learning algorithm to extract transcriptomic and epigenetic feature sets derived from non-transformed pluripotent stem cells and their differentiated progeny. (nih.gov)
• PHF20 functions as a key epigenetic regulator of stem cell self-renewal and cellular reprogramming ( 10 ), and is abundantly expressed in several cancers ( 11 - 14 ). (frontiersin.org)

Receptor1

• CD19 has been targeted through genetically engineered chimeric-antigen receptor (CAR) T cells, and via bispecific CD3-CD19 antibodies, with reports of relapse via CD19 loss. (nih.gov)

Pluripotent3

• 20. Concise review: Induced pluripotent stem cells versus embryonic stem cells: close enough or yet too far apart? (nih.gov)
• They have a pluripotent population of stem cells that just hangs out in the body at all [times] and is sporadically replacing damaged cells. (discovermagazine.com)
• My postdoctoral work in Professor Marianne Bronner's laboratory demonstrated that neural crest cells, despite their transient nature, maintain a premigratory stem cell niche of self-renewing and pluripotent cells located in the dorsal neural tube. (nih.gov)

Transcription1

• Combined overexpression of four transcription factors promotes effector T cell dedifferentiation toward early phenotypes. (bvsalud.org)

Progression1

• This progression from stem to progenitor to mature cells goes only one way. (nih.gov)

Immune1

• His lab has also demonstrated the use of MDSC, as a cell-based tolerogenic therapy, to suppress unwanted immune responses, such as autoimmunity and graft-versus-host diseases (GVHD), while still retaining graft verse leukemia (GVL) function. (houstonmethodist.org)

Characterization4

• Characterization of Arsenic-Induced Cancer Stem-Like Cells. (nih.gov)
• Characterization of the extracellular matrix components that control the stability or expansion of hair cells. (nih.gov)
• Characterization of cell-cell interactions involved in stabilizing hair cell-support cell interactions. (nih.gov)
• My graduate work focused on characterization of regulatory functions in mouse neural stem cells. (nih.gov)

CSCs1

• Cancer stem cells (CSCs) have been widely recognized as a key feature of GBM ( 2 , 3 ). (frontiersin.org)

Schwann6

• However, the inhibition of actin polymerization could not block Schwann cell dedifferentiation. (jneurosci.org)
• As peripheral nerves develop, Schwann cells extend their processes into axon bundles to sort out an axon destined to be myelinated. (jneurosci.org)
• Then, Schwann cells obtain a one-to-one relationship with the axon and form myelin by spiraling their membrane around the axon ( Mirsky and Jessen, 1999 ). (jneurosci.org)
• These morphological changes of Schwann cells are likely to be mediated by the actin cytoskeleton, which plays a key role in cell shape changes in response to various stimuli. (jneurosci.org)
• Since cytoskeletal dynamics might be involved in the extensive morphological changes of Schwann cells during demyelination, we investigated the role of actin filaments in the disruption of SLI and subsequent myelin ovoid formation. (jneurosci.org)
• The PNS is myelinated by Schwann cells which ensheathe and myelinate the large caliber axons and allow rapid (saltatory) conduction of nerve impulses. (plymouth.ac.uk)

Reprogram1

• Previous studies have shown that the exogenous overexpression of four essential factors (POU3F2, SOX2, SALL2, and OLIG2) is sufficient to fully reprogram differentiated GBM cells and induce poorly differentiated GBM stem-like cells ( 7 ). (frontiersin.org)

Inhibition1

• Imprinting affects various essential cellular and developmental processes, including intercellular signaling, RNA processing, cell cycle control, and promotion or inhibition of cellular division and growth. (justia.com)

Vitro1

• I made this discovery by creating novel techniques such as developing crestospheres, an in vitro method to maintain neural crest stem cells in a self-renewing state. (nih.gov)

Invasion1

• Aim: The aim of this study is to identify CCs in various histological grades of oral squamous cell carcinoma (OSCC) and to relate them with the pattern of invasion, lymphocytic response (LR), and mitotic figures (Mfs). (who.int)

Characteristics1

• I then continued as a Post Doctoral Fellow at the California Institute of Technology where I initiated my research on stem cell characteristics of the neural crest by adopting the early chicken embryo as my model system. (nih.gov)

McSC1

• For unknow reasons, the melanocyte stem cell (McSC) system fails earlier than other adult stem cell populations 1 , which leads to hair greying in most humans and mice 2,3 . (nih.gov)

Mice2

• Results: Four weeks administration of Ex-4 resulted in an off-drug amelioration of glucose excursions after glucose loading in Wfs1 −/− mice, with insulin secretory dynamics that were indistinguishable from those in WT mice, despite no alteration in beta cell mass. (diabetesjournals.org)
• Murine CD19 CAR treatment of ALL-bearing mice resulted in long-term remission with long persistence of T cells. (nih.gov)

Cancer3

• 8. Tumoral stem cell reprogramming as a driver of cancer: Theory, biological models, implications in cancer therapy. (nih.gov)
• However, cancer cells tend to follow anti-Dollo's law. (who.int)
• Unfavorable conditions such as hypoxia, acidic pH and low nutrients cause the cancer cells to switch their lifestyle atavistically in order to survive. (who.int)

Tissue7

• Recent work has highlighted the key role of dedifferentiation as a conserved mechanism for replenishing stem cell pools after their loss, thereby maintaining tissue homeostasis . (bvsalud.org)
• Following injury, the clearance of apoptotic and necrotic cells is necessary for mitigation and resolution of inflammation and tissue repair. (jci.org)
• Essentially, what that does is that they take whatever's remaining in the tissue, and they just shuffle the cells around, reorganize them, so that makes a perfectly formed mini-version with all of the appropriate structures," says McCusker. (discovermagazine.com)
• Disease-associated forms of resistant prion protein (PrP Res ) are likely transported from the gut to lymphoid tissue by cells such as migrating intestinal dendritic cells ( 6 ). (cdc.gov)
• Once in the lymphoid tissue PrP Res appears to be amplified by follicular dendritic cells ( 6 ) and then enters the nervous system. (cdc.gov)
• Establishment of human cell lines from embryonic ear tissue. (nih.gov)
• New findings enhanced our understanding of adult stem cells in ways that may enable researchers to expand their use for tissue and organ repair. (nih.gov)

Neoplastic1

• This invention relates generally to screening for risk or or presence of neoplastic disorders, and more particularly to screening for biomarkers present in a biological sample obtained from a subject that are indicative of a predisposition for a neoplastic (e.g., benign or malignant) or cell proliferative disorder. (justia.com)

Progenitors3

• Meanwhile, the original stem cells remain as stem cells, separate from the progenitors. (nih.gov)
• Investigation of the otic placode as one possible beginning source to identify progenitors, although cells are already developmentally biased. (nih.gov)
• potential progenitors, supporting cells, etc. (nih.gov)

Surface markers1

• Later relapses had loss of all the B cell surface markers, along with down regulation of B cell transcripts (such as EBF1 and PAX5) in the mRNA. (nih.gov)

Tumour1

• 5. How tumour cell identity is established? (nih.gov)