Cell Communication: Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP.Gap Junctions: Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of CONNEXINS, the family of proteins which form the junctions.Communication: The exchange or transmission of ideas, attitudes, or beliefs between individuals or groups.Intercellular Junctions: Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Connexins: A group of homologous proteins which form the intermembrane channels of GAP JUNCTIONS. The connexins are the products of an identified gene family which has both highly conserved and highly divergent regions. The variety contributes to the wide range of functional properties of gap junctions.Coculture Techniques: A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Drosophila: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Animal Communication: Communication between animals involving the giving off by one individual of some chemical or physical signal, that, on being received by another, influences its behavior.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Communication Disorders: Disorders of verbal and nonverbal communication caused by receptive or expressive LANGUAGE DISORDERS, cognitive dysfunction (e.g., MENTAL RETARDATION), psychiatric conditions, and HEARING DISORDERS.Health Communication: The transfer of information from experts in the medical and public health fields to patients and the public. The study and use of communication strategies to inform and influence individual and community decisions that enhance health.Communication Aids for Disabled: Equipment that provides mentally or physically disabled persons with a means of communication. The aids include display boards, typewriters, cathode ray tubes, computers, and speech synthesizers. The output of such aids includes written words, artificial speech, language signs, Morse code, and pictures.Nonverbal Communication: Transmission of emotions, ideas, and attitudes between individuals in ways other than the spoken language.Communication Barriers: Those factors, such as language or sociocultural relationships, which interfere in the meaningful interpretation and transmission of ideas between individuals or groups.Physician-Patient Relations: The interactions between physician and patient.Computer Communication Networks: A system containing any combination of computers, computer terminals, printers, audio or visual display devices, or telephones interconnected by telecommunications equipment or cables: used to transmit or receive information. (Random House Unabridged Dictionary, 2d ed)Radiology Information Systems: Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of radiology services and facilities.Connexin 43: A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.Hospital Communication Systems: The transmission of messages to staff and patients within a hospital.Interdisciplinary Communication: Communication, in the sense of cross-fertilization of ideas, involving two or more academic disciplines (such as the disciplines that comprise the cross-disciplinary field of bioethics, including the health and biological sciences, the humanities, and the social sciences and law). Also includes problems in communication stemming from differences in patterns of language usage in different academic or medical disciplines.Communication Methods, Total: Utilization of all available receptive and expressive modes for the purpose of achieving communication with the hearing impaired, such as gestures, postures, facial expression, types of voice, formal speech and non-speech systems, and simultaneous communication.Endothelium, Corneal: Single layer of large flattened cells covering the surface of the cornea.Exosomes: A type of extracellular vesicle, containing RNA and proteins, that is secreted into the extracellular space by EXOCYTOSIS when MULTIVESICULAR BODIES fuse with the PLASMA MEMBRANE.Cell-Derived Microparticles: Extracellular vesicles generated by the shedding of CELL MEMBRANE blebs.Breast Neoplasms: Tumors or cancer of the human BREAST.Bioengineering: The application of engineering principles and methods to living organisms or biological systems.Biomedical Engineering: Application of principles and practices of engineering science to biomedical research and health care.CaliforniaQuorum Sensing: A phenomenon where microorganisms communicate and coordinate their behavior by the accumulation of signaling molecules. A reaction occurs when a substance accumulates to a sufficient concentration. This is most commonly seen in bacteria.National Institute of Biomedical Imaging and Bioengineering (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. Its mission is to improve health by leading the development and accelerating the application of biomedical technologies, and integrating the physical and engineering sciences with the life sciences to advance basic research and medical care. It was established in 2000.Transduction, Genetic: The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.DenmarkRadiology Department, Hospital: Hospital department which is responsible for the administration and provision of x-ray diagnostic and therapeutic services.Plants, Genetically Modified: PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.Pseudomonas aeruginosa: A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.Pyocyanine: Antibiotic pigment produced by Pseudomonas aeruginosa.Pseudomonas Infections: Infections with bacteria of the genus PSEUDOMONAS.Bacterial Proteins: Proteins found in any species of bacterium.BooksPatient Handoff: The transferring of patient care responsibility from one health-care professional to another.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)

The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping. (1/8670)

Left-right asymmetry in vertebrates is controlled by activities emanating from the left lateral plate. How these signals get transmitted to the forming organs is not known. A candidate mediator in mouse, frog and zebrafish embryos is the homeobox gene Pitx2. It is asymmetrically expressed in the left lateral plate mesoderm, tubular heart and early gut tube. Localized Pitx2 expression continues when these organs undergo asymmetric looping morphogenesis. Ectopic expression of Xnr1 in the right lateral plate induces Pitx2 transcription in Xenopus. Misexpression of Pitx2 affects situs and morphology of organs. These experiments suggest a role for Pitx2 in promoting looping of the linear heart and gut.  (+info)

oko meduzy mutations affect neuronal patterning in the zebrafish retina and reveal cell-cell interactions of the retinal neuroepithelial sheet. (2/8670)

Mutations of the oko meduzy (ome) locus cause drastic neuronal patterning defect in the zebrafish retina. The precise, stratified appearance of the wild-type retina is absent in the mutants. Despite the lack of lamination, at least seven retinal cell types differentiate in oko meduzy. The ome phenotype is already expressed in the retinal neuroepithelium affecting morphology of the neuroepithelial cells. Our experiments indicate that previously unknown cell-cell interactions are involved in development of the retinal neuroepithelial sheet. In genetically mosaic animals, cell-cell interactions are sufficient to rescue the phenotype of oko meduzy retinal neuroepithelial cells. These cell-cell interactions may play a critical role in the patterning events that lead to differentiation of distinct neuronal laminae in the vertebrate retina.  (+info)

The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase. (3/8670)

Stimulation of the hepatocyte growth factor (HGF) receptor tyrosine kinase, Met, induces mitogenesis, motility, invasion, and branching tubulogenesis of epithelial and endothelial cell lines in culture. We have previously shown that Gab1 is the major phosphorylated protein following stimulation of the Met receptor in epithelial cells that undergo a morphogenic program in response to HGF. Gab1 is a member of the family of IRS-1-like multisubstrate docking proteins and, like IRS-1, contains an amino-terminal pleckstrin homology domain, in addition to multiple tyrosine residues that are potential binding sites for proteins that contain SH2 or PTB domains. Following stimulation of epithelial cells with HGF, Gab1 associates with phosphatidylinositol 3-kinase and the tyrosine phosphatase SHP2. Met receptor mutants that are impaired in their association with Gab1 fail to induce branching tubulogenesis. Overexpression of Gab1 rescues the Met-dependent tubulogenic response in these cell lines. The ability of Gab1 to promote tubulogenesis is dependent on its pleckstrin homology domain. Whereas the wild-type Gab1 protein is localized to areas of cell-cell contact, a Gab1 protein lacking the pleckstrin homology domain is localized predominantly in the cytoplasm. Localization of Gab1 to areas of cell-cell contact is inhibited by LY294002, demonstrating that phosphatidylinositol 3-kinase activity is required. These data show that Gab1 is an important mediator of branching tubulogenesis downstream from the Met receptor and identify phosphatidylinositol 3-kinase and the Gab1 pleckstrin homology domain as crucial for subcellular localization of Gab1 and biological responses.  (+info)

p27 is involved in N-cadherin-mediated contact inhibition of cell growth and S-phase entry. (4/8670)

In this study the direct involvement of cadherins in adhesion-mediated growth inhibition was investigated. It is shown here that overexpression of N-cadherin in CHO cells significantly suppresses their growth rate. Interaction of these cells and two additional fibroblastic lines with synthetic beads coated with N-cadherin ligands (recombinant N-cadherin ectodomain or specific antibodies) leads to growth arrest at the G1 phase of the cell cycle. The cadherin-reactive beads inhibit the entry into S phase and the reduction in the levels of cyclin-dependent kinase (cdk) inhibitors p21 and p27, following serum-stimulation of starved cells. In exponentially growing cells these beads induce G1 arrest accompanied by elevation in p27 only. We propose that cadherin-mediated signaling is involved in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of p27 levels.  (+info)

Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact. (5/8670)

Embryological data suggest that endothelial cells (ECs) direct the recruitment and differentiation of mural cell precursors. We have developed in vitro coculture systems to model some of these events and have shown that ECs direct the migration of undifferentiated mesenchymal cells (10T1/2 cells) and induce their differentiation toward a smooth muscle cell/pericyte lineage. The present study was undertaken to investigate cell proliferation in these cocultures. ECs and 10T1/2 cells were cocultured in an underagarose assay in the absence of contact. There was a 2-fold increase in bromodeoxyuridine labeling of 10T1/2 cells in response to ECs, which was completely inhibited by the inclusion of neutralizing antiserum against platelet-derived growth factor (PDGF)-B. Antisera against PDGF-A, basic fibroblast growth factor, or transforming growth factor (TGF)-beta had no effect on EC-stimulated 10T1/2 cell proliferation. EC proliferation was not influenced by coculture with 10T1/2 cells in the absence of contact. The cells were then cocultured so that contact was permitted. Double labeling and fluorescence-activated cell sorter analysis revealed that ECs and 10T1/2 cells were growth-inhibited by 43% and 47%, respectively. Conditioned media from contacting EC-10T1/2 cell cocultures inhibited the growth of both cell types by 61% and 48%, respectively. Although we have previously shown a role for TGF-beta in coculture-induced mural cell differentiation, growth inhibition resulting from contacting cocultures or conditioned media was not suppressed by the presence of neutralizing antiserum against TGF-beta. Furthermore, the decreased proliferation of 10T1/2 cells in the direct cocultures could not be attributed to downregulation of the PDGF-B in ECs or the PDGF receptor-beta in the 10T1/2 cells. Our data suggest that modulation of proliferation occurs during EC recruitment of mesenchymal cells and that heterotypic cell-cell contact and soluble factors play a role in growth control during vessel assembly.  (+info)

Cell surface sialic acid and the regulation of immune cell interactions: the neuraminidase effect reconsidered. (6/8670)

It has been known for over a decade that sialidase (neuraminidase) treatment could substantially enhance the capacity of resting B cells to stimulate the proliferation of allogeneic and antigen specific, syngeneic T cells. Thus, cell-surface sialic acid was implicated as a potential modulator of immune cell interaction. However, little progress has been made in either identifying explicit roles for sialic acid in this system or in hypothesizing mechanisms to explain the "neuraminidase effect." Here we show for the first time that cell surface sialic acid on medium incubated B cells blocks access to costimulatory molecules on the B cell surface, and that this is the most likely explanation for the neuraminidase effect. Further, we show that it is likely to be upregulation of ICAM-1 and its subsequent engagement of LFA-1 rather than loss of cell surface sialic acid that in part regulates access to CD86 and other costimulatory molecules. However, we cannot exclude a role for CD86-bound sialic acid on the B cell in modulating binding to T cell CD28. Because sialidase treatment of resting B cells but not resting T cells enables T cell activation, we suggest that sialidase treatment may still be an analogue for an authentic step in B cell activation, and show that for highly activated B cells (activated with polyclonal anti-IgM plus INF-gamma) there is specific loss 2, 6-linked sialic acid. Potential roles for sialic acid in modulating B cell/T cell collaboration are discussed.  (+info)

Glucocorticoid down-regulation of fascin protein expression is required for the steroid-induced formation of tight junctions and cell-cell interactions in rat mammary epithelial tumor cells. (7/8670)

Glucocorticoid hormones, which are physiological regulators of mammary epithelium development, induce the formation of tight junctions in rat Con8 mammary epithelial tumor cells. We have discovered that, as part of this process, the synthetic glucocorticoid dexamethasone strongly and reversibly down-regulated the expression of fascin, an actin-bundling protein that also interacts with the adherens junction component beta-catenin. Ectopic constitutive expression of full-length mouse fascin containing a Myc epitope tag (Myc-fascin) in Con8 cells inhibited the dexamethasone stimulation of transepithelial electrical resistance, disrupted the induced localization of the tight junction protein occludin and the adherens junction protein beta-catenin to the cell periphery, and prevented the rearrangement of the actin cytoskeleton. Ectopic expression of either the carboxyl-terminal 213 amino acids of fascin, which includes the actin and beta-catenin-binding sites, or the amino-terminal 313 amino acids of fascin failed to disrupt the glucocorticoid induction of tight junction formation. Mammary tumor cells expressing the full-length Myc-fascin remained generally glucocorticoid responsive and displayed no changes in the levels or protein-protein interactions of junctional proteins or the amount of cytoskeletal associated actin filaments. However, a cell aggregation assay demonstrated that the expression of Myc-fascin abrogated the dexamethasone induction of cell-cell adhesion. Our results implicate the down-regulation of fascin as a key intermediate step that directly links glucocorticoid receptor signaling to the coordinate control of junctional complex formation and cell-cell interactions in mammary tumor epithelial cells.  (+info)

Novel insights into human endometrial paracrinology and embryo-maternal communication by intrauterine microdialysis. (8/8670)

The regulation of human implantation is still unknown. Evidence from mice suggests an essential role for several paracrine mediators but species differences with implantation in the human preclude the extrapolation of these concepts to humans. An intrauterine microdialysis device (IUMD), consisting of microdialysis tubing glued into a balloon catheter on one side and into a polypropylene tube on the other, allows a dynamic and accurate in-vivo measurement of uterine paracrine interactions in humans. Inserted into the uterine cavity in the form of a loop, it can be continuously perfused with saline to reveal a number of relevant cytokines and growth factors in uterine effluents of non-pregnant women in both follicular and luteal phases. These included interleukin (IL)-1alpha, IL-1beta, IL-6, leukaemia inhibitory factor (LIF), macrophage colony-stimulating factor (M-CSF), epidermal growth factor, vascular endothelial growth factor (VEGF), insulin-like growth factor binding protein-1 (IGFBP-1), prolactin, and human chorionic gonadotrophin (HCG). The source of intrauterine HCG is unclear since endometrial mRNA for the HCG beta-subunit is not revealed using reverse transcriptase polymerase chain reaction analysis. Applying urinary HCG locally via the IUMD profoundly alters endometrial secretory parameters. Prolactin, IGFBP-1, and M-CSF are significantly inhibited and VEGF is regulated in a biphasic manner involving early stimulation followed by inhibition of intrauterine levels. Use of the IUMD has thus shown that the urinary HCG preparations routinely used for ovulation induction and luteal support may directly alter endometrial function.  (+info)

*Cell Communication & Adhesion

Intercelluar communication Intercellular junctions Receptor-based cell recognition & signaling Cell Communication & Adhesion is ... Cell Communication & Adhesion homepage of Cell Communication & Adhesion. ... FRACP are the regional editors of Cell Communication & Adhesion. Cell Communication & Adhesion publishes 6 issues per year in ... Cell Communication & Adhesion is an academic journal that publishes review articles on intercellular communication, ...

*Cell communication (biology)

Much of cell communication happens when ligands bind to the receptors of the cell membrane and control the actions of the cell ... lack the cell communication that characterizes normal cells. "Cellular communication through membrane junctions: Special ... However, it is also through cell signaling that tumors and cancer can also develop. Stem cells and tumor-causing cells, however ... and direct communication, which means signals pass inside the cell itself. The junctions of these cells is incredibly important ...

*Cell Communication and Signaling

... has been the editor-in-chief of Cell Communication and Signaling since April 2008. In June 2012, Cell Communication and ... The Biological Systems Architecture Group Cell Communication and Signaling - Editorial Board Journal Citation Reports - Cell ... Cell Communication and Signaling is a peer-reviewed and open access scientific journal that publishes original research, ...

*Plakophilin-2

Cell Communication & Adhesion. 16 (1-3): 15-27. doi:10.1080/15419060903009329. PMID 19533476. Kirchner F, Schuetz A, Boldt LH, ... Plakophilin-2 over time has shown to be more than components of cell-cell junctions; rather the plakophilins are emerging as ... Cell Genet. 88 (3-4): 286-7. doi:10.1159/000015540. PMID 10828611. Hofmann I, Mertens C, Brettel M, Nimmrich V, Schnölzer M, ... Cell. Proteomics. 4 (6): 785-95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465. Kimura K, Wakamatsu A, Suzuki Y, Ota T, ...

*Tandem mass spectrometry

Gafken PR, Lampe PD (2006). "Methodologies for characterizing phosphoproteins by mass spectrometry". Cell Communication & ...

*GJA1

... which allow for gap junction intercellular communication (GJIC) between cells to regulate cell death, proliferation, and ... Furthermore, GJA1 is expressed in many immune cells, such as eosinophils and T cells, where its gap junction function promotes ... In addition, GJA1 can be found in the Leydig cells and seminiferous tubules between Sertoli cells and spermatogonia or primary ... Cell Communication & Adhesion. 10 (4-6): 201-5. doi:10.1080/cac.10.4-6.201.205. PMID 14681016. Andrew L Harris and Darren Locke ...

*Richard Hynes

Pioneer of Cell-Matrix Interactions". Cell Communication & Adhesion. 20 (6): 139. doi:10.3109/15419061.2013.857662. "Richard O ... His research focuses on cell adhesion and the interactions between cells and the extracellular matrix, with a particular ... Hynes served as the president of the American Society for Cell Biology in 2000. He has been a member of the Board of Governors ... In 2007, the American Society for Cell Biology awarded Hynes and Zena Werb their most prestigious award, the E.B. Wilson Medal ...

*Three-finger toxin

Cell Communication & Adhesion. 13 (3): 171-183. doi:10.1080/15419060600726183. ISSN 1541-9061. PMID 16798616. Konshina, ... though some members may cause physical damage to the cell by establishing pores in the cell membrane. Another class, called the ... Many members of the family are neurotoxins that bind to receptor proteins in the cell membrane, particularly nicotinic ... as well as possible functionally significant interactions with other cell-surface molecules such as glycosaminoglycans. A ...

*GAB2

Cell Communication and Signaling. 7 (22): 22. doi:10.1186/1478-811X-7-22. PMC 2747914 . PMID 19737390. Simister PC, Feller SM ( ... GC-GAP is responsible for the proliferation of astroglioma cells. The interaction between GAB2 and Grb2 at the cell membrane ... It is a member of the GAB/DOS family localized on the internal membrane of the cell. It mediates the interaction between ... PI3K activation by GAB2 promotes cell growth. The effects of all the pathways activated by GAB proteins are not known, but it ...

*Ectoderm

Cell Communication and Signaling. 10 (1): 34. doi:10.1186/1478-811X-10-34. PMC 3515343 . PMID 23176204. Priolo, M.; Laganà, C ( ... The DLHP cells function in a similar fashion as MHP cells regarding their wedge like shape, however, the DLHP cells result in ... These special cells are called medial hinge cells (MHP). Now, as the ectoderm continues to elongate, the ectodermal cells of ... The neural crest cells eventually pull the adjacent ectodermal cells together, which leaves neural crest cells between the ...

*Causes of cancer

Cell Communication and Signaling. 9 (18): 18. doi:10.1186/1478-811X-9-18. PMID 21914164. Henderson BE, Bernstein L, Ross RK ( ... Major damage normally results in the cell dying, but smaller damage may leave a stable, partly functional cell that may be ... Such reactions may protect against tumor cell engraftment by eliminating implanted cells. In the United States, approximately ... and Human T-cell leukemia virus-1 (T-cell leukemias). Bacterial infection may also increase the risk of cancer, as seen in ...

*Piers Nash

Cell Communication and Signaling. 10 (1): 27. doi:10.1186/1478-811X-10-27. PMC 3514216 . PMID 22974441. Clarke, Michael; Lohan ... Harper, J.Wade (2002). "A phosphorylation-driven ubiquitination switch for cell-cycle control". Trends in Cell Biology. 12 (3 ... This article was the focus of the following reviews and comments: Ferrell, James E. (2001). "Cell cycleSix steps to destruction ... 2007). "Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor". Journal of Immunology. 179 (7 ...

*ANKS1A

... is a Src family kinase target in colorectal cancer cells". Cell Communication and Signaling. 6: 7. doi:10.1186/1478-811X-6-7. ... is a Src family kinase target in colorectal cancer cells". Cell Communication and Signaling. 6: 7. doi:10.1186/1478-811X-6-7. ... ODIN may be involved in cancer cell signaling mechanisms. In a study, 64 colorectal cancer cell lines were tested for their ... The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA ...

*Succinic acid

As such, succinate links TCA cycle dysfunction or metabolic changes to cell-cell communication and to oxidative stress-related ... Succinate may enhance adaptive immunity by triggering the activity of antigen-presenting cells that, in turn, activate T-cells ... Enzymes required for the GABA shunt are expressed in neurons, glial cells, macrophages and pancreatic cells. Succinate is ... Cell Communication and Signaling. 14: 3. doi:10.1186/s12964-016-0126-1. PMC 4709936 . PMID 26759054. Bardella, Chiara; Pollard ...

*Heredity

Developmental biologists suggest that complex interactions in genetic networks and communication among cells can lead to ... Before a cell divides through mitosis, the DNA is copied, so that each of the resulting two cells will inherit the DNA sequence ... Cell Communication and Signaling. 9 (30): 30. doi:10.1186/1478-811X-9-30. PMC 3215633 . "Francis Galton (1822-1911)". Science ... Down syndrome sickle cell disease Phenylketonuria (PKU) Haemophilia An allele is said to be dominant if it is always expressed ...

*Nest (protein structural motif)

Lee, H-J; Zheng JJ (2010). "PDZ Domains and their binding Partners: Strucure Specificty and Modification". Cell Communication ... thereby preventing bacterial cells from multiplying. Nests are defined by the conformation of the main chain atoms, namely the ... in the antibiotic peptide vancomycin which binds a key carboxylate group utilized during the final stages of bacterial cell ...

*International Max Planck Research School for Molecular and Cellular Life Sciences

... cell communication; 5.) biophysics, membranes & transport; 6.) multiscale imaging & visualization and 7.) computational & ... cell biology, molecular medicine, neurobiology and structural biology. IMPRS-LS is 100% committed to basic research and aims to ...

*Chemical genetics

Cell Communication and Signaling. 8 (1): 11. doi:10.1186/1478-811x-8-11. PMC 2912314 . PMID 20540792. Ny A, Autiero M, ... In addition to cells, Xenopus or zebrafish embryos can also be screened in 96 well format where compounds are dissolved in the ... These screens can be done in a high-throughput mode, using 96 well-plates, where each well contains cells treated with a unique ... Chemical genetics is the investigation of the function of proteins and signal transduction pathways in cells by the screening ...

*Short linear motif

Cell Communication and Signaling. 13 (1): 43. doi:10.1186/s12964-015-0120-z. PMC 4654906 . PMID 26589632. Ren, S.; Yang, G.; He ... Gril B, Vidal M, Assayag F, Poupon MF, Liu WQ, Garbay C (2007). "Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and ... E. Coli injects a protein, EspF(U), that mimics an autoinhibitory element of N-WASP into the host cell to activate actin- ... The KDEL motif of the bacteria encoded cholera toxin mediates cell entry of the cholera toxin. Linear motif mediated protein- ...

*Hidesaburo Hanafusa

Cell Communication and Signaling. 7: 7. doi:10.1186/1478-811X-7-7. PMC 2673226 . PMID 19379504. Foster, David A.; Darnell Jr, ...

*PDGFRB

Heldin CH (2013). "Targeting the PDGF signaling pathway in tumor treatment". Cell Communication and Signaling : CCS. 11: 97. ... In vitro studies using cultured cells indicate that endothelial cells secrete PDGF, which recruits PDGFRβ-expressing pericytes ... Olson LE, Soriano P (2011). "PDGFRβ signaling regulates mural cell plasticity and inhibits fat development". Developmental Cell ... Cell. Biol. 12 (12): 5824-33. doi:10.1128/MCB.12.12.5824. PMC 360522 . PMID 1333047. Chen M, She H, Davis EM, Spicer CM, Kim L ...

*Ricardo Rosselló

Rosselló, RA; Kohn, DH (2010). "Cell communication and tissue engineering". Communicative & integrative biology. 3 (1): 53-56. ... He has worked in South America alongside other stem cell doctors in developing better stem cell treatment. He claimed to have ... His work in the stem cell research area has been subject of several awards, such as the Biomaterials Conference STAR Award and ... As a researcher in college, Rosselló focused on adult stem cell research. After graduation, Rosselló worked as a researcher at ...

*NOV (gene)

Journal of Cell Communication and Signaling. 6 (1): 27-35. doi:10.1007/s12079-011-0142-2. PMC 3271200 . PMID 21773872. ... It is essential for self-renewal of CD34+ hematopoietic stem cells from umbilical cord blood. NOV can bind BMP2 and inhibit its ... Ellis PD, Metcalfe JC, Hyvönen M, Kemp PR (2003). "Adhesion of endothelial cells to NOV is mediated by the integrins ... Forced expression of NOV inhibits proliferation and restores growth control in CML cells, suggesting that NOV may be an ...

*Nuclease

Rittié, Laure; Perbal, Bernard (2008). "Enzymes used in molecular biology: a useful guide". Journal of Cell Communication and ... With all cells depending on DNA as the medium of genetic information, genetic quality control is an essential function of all ... A ubiquitous task in cells is the removal of Okazaki fragment RNA primers from replication. Most such primers are excised from ... Double-strand breaks, both intentional and unintentional, regularly occur in cells. Unintentional breaks are commonly generated ...

*WNT1-inducible-signaling pathway protein 2

Russo JW, Castellot JJ (Oct 2010). "CCN5: biology and pathophysiology". Journal of Cell Communication and Signaling. 4 (3): 119 ... WISP-2 (CCN5) inhibits the proliferation of vascular smooth muscle cells, human uterine myometrial cells, and leiomyoma cells. ... Lake AC, Bialik A, Walsh K, Castellot JJ (Jan 2003). "CCN5 is a growth arrest-specific gene that regulates smooth muscle cell ... Ectopic expression of WISP-2 also inhibits the motility and invasiveness of breast carcinoma cells. WISP-2 also inhibits ...

*Technopark, Trivandrum

Technopark also hosts a Technology Business Incubation Cell under Kerala Startup Mission. In March 1990, the Government of ... Technopark offers as many as 8 Internet Service Providers - BSNL, Reliance Infratel, TATA Communication, Bharti Airtel, Asianet ... "Exports from companies in Technopark: Chapter 21, page:502, section:21.8" (PDF). Information And Communication Technology. ... "Exports from companies in Technopark: Chapter 21, page:220, section:21.66" (PDF). Information And Communication Technology. ...
A cellular communications system is provided have both satellite nodes and surface nodes for providing mobile cellular communications services for a plurality of mobile user units. The surface and satellite nodes are fully integrated by a network controller for providing service over large areas. Multiple beam, relatively high gain antennas are disposed in the satellite nodes to establish satellite cells having enough gain in the satellite part of the system such that a user unit need only comprise a small, mobile handset with a non-directional antenna for communications with both ground nodes and satellite nodes.
The development of multicellular organisms relies heavily on cell communication. Cells send and receive complex sets of signals, harmonising their growth and differentiation with that of other, often distant, cell populations. In animals, the Epidermal Growth Factor Receptor (EGFR) is an important mediator of cell communication. EGFR activation regulates various developmental events in nematodes, insects and vertebrates. In addition, mutations in human EGFRs have been associated with a number of cancers. In Drosophila, a key event triggering EGFR signalling is the regulated release of the extracellular portion of EGFR ligands. Rhomboid (Rho), an unusual polytopic protease, cleaves the transmembrane, inactive ligand precursor into an active, soluble form. Both the target sequence and Rho s catalytic site are embedded within the membrane bilayer and for this reason the reaction has been described as regulated intramembrane proteolysis. The work presented in this thesis begins with the ...
View Notes - ENGR213_lecture3 from ENGR 213 at Cal Poly. Cell Signaling and Cellular Communication Lecture 3 What is Cell Signaling ? Cell signaling is part of a complex system of communication
View Notes - Chapter 11 from BIOL 211 at Bellevue College. Chapter 11 Cell Communication Overview: The Cellular Internet Cell-to-cell communication is essential for multicellular organisms Biologists
describes what glyconutritionals are and how they are used to increase cellular communication, which in turn provides optimal health.
Applying biological molecules from cell membranes to the surfaces of artificial materials is opening peepholes on the very basics of cell-to-cell interaction.
Sudoc Catalogue :: - Livre / BookAnalysis of HIV-1 cell-to-cell transfer to macrophages / Lucie Bracq ; sous la direction de Serge Bénichou et de Paul Zhou
Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma: DC Activation Occurs in the Airway Mucosa but Not in the Lung ...
Mechanism-based model characterizing bidirectional interaction between PEGylated liposomal CKD-602 (S-CKD602) and monocytes in cancer patients Huali Wu,1 Ramesh K Ramanathan,2 Beth A Zamboni,3 Sandra Strychor,4 Suresh Ramalingam,5 Robert P Edwards,4 David M Friedland,4 Ronald G Stoller,4 Chandra P Belani,4 Lauren J Maruca,4 Yung-Jue Bang,6 William C Zamboni11UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA; 2Translational Research Division, The Translational Genomics Research Institute, Scottsdale, AZ, USA; 3Department of Mathematics, Carlow University, Pittsburgh, PA, USA; 4School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; 5Winship Cancer Institute, Emory University, Atlanta, GA, USA; 6College of Medicine, Seoul National University, Seoul, KoreaAbstract: S-CKD602 is a PEGylated liposomal formulation of CKD-602, a potent topoisomerase I inhibitor. The objective of this study was to characterize the bidirectional pharmacokinetic-pharmacodynamic (PK-PD)
Study Flashcards On Biology Chapter 11 Cell Communication at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Purchase Gap Junctions: Molecular Basis of Cell Communication in Health and Disease, Volume 49 - 1st Edition. Print Book & E-Book. ISBN 9780125506458, 9780080925240
How it works: Rebuilding cell theory. Garcias early research disproved a long-standing hypothesis concerning this cellular feature.. Mammals nervous systems are uniquely equipped with myelination, which has been shown to increase conduction velocity, or the speed at which nerve cells pass signals. Low velocity is often associated with neurodegenerative diseases, so research exploring why could later have application in therapeutic technology.. In addition to myelination, cell size makes a big difference in conduction velocity - the bigger the nerve cells, the faster they can pass and receive signals. Garcias findings disproved a hypothesis that related myelination to this phenomenon.. The hypothesis, published in a 1992 edition of Cell, claimed that myelination causes a cellular process called phosphorylation which then causes an increase in the axonal diameter (width of the communicating part of a nerve cell), leading to faster nerve cell communication. Garcia found that myelination did ...
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Welcoming basic and translational aspects of cell communication and signaling research that influence cellular morphology, structure, and function in both ...
Welcoming basic and translational aspects of cell communication and signaling research that influence cellular morphology, structure, and function in both ...
Citation Machine™ helps students and professionals properly credit the information that they use. Cite your raw rata in Cell Communication and Signaling format for free.
HIV-1 is believed to spread by two mechanisms in an infected host: by cell-free virions and by cell-associated transmission. The mechanisms of HIV-1 cell-to-cell transmission were not well understood until the recent description of the virological synapse (VS). The VS is a specialised supramolecular structure, formed between an infected effector cell and a permissive target cell, to facilitate direct virus infection of the permissive cell. Direct cell-to-cell spread is probably an important mechanism in tissues densely populated with target cells, such as CD4+ T cells in lymph nodes and the GALT. Moreover, VS-mediated viral transfer may help the virus to hide from elements of the immune system, such as neutralising antibodies and complement. Many areas relating to HIV-1 cell-to-cell spread and VS function remain to be explored. Therefore, the aim of the project behind this thesis was to extend our initial molecular characterisation of the supramolecular structure of VS in T cells and to ...
Join VIB at its first conference on Structural dynamics in cellular communication that will take place in an architecturally significant venue in the heart of Europe (Brussels, Belgium) from 9-10 February, 2015.. The conference will cover the latest advances in protein science, focusing on systems structural biology, the functional role of structural dynamics, the organization of complexes and key technological advances. During four plenary sessions this first edition will handle the following topics: macromolecular machines and assemblages; protein network dynamics; protein fluctuations and function; and membrane proteins and complexes ...
Its safe to say that cilia, the hairlike appendages jutting out from the smooth surfaces of most mammalian cells, have long been misunderstood - underestimated, even.
Read "Direct cell-cell communications and social behavior of cells in mammals, protists, and bacteria. Possible causes of multicellularity, Russian Journal of Developmental Biology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
The book comprises ten chapters written by experts in the field on cell-cell interactions and their role in biology and medicine. Cell-cell interactions are the means by which cells are able to communicate, transfer information, develop spatial awareness and coordinate their differentiation. The ten areas have been selected for their breadth and relevance to modern research scientists where cell-cell interactions have been shown to play a critical role in biological processes.
lectrical stimulation and allow calcium to flow into dendritic spines.... In their study Sabatini and Svoboda could detect if single calcium... Visually examining calcium fluctuations in a single dendritic spin... But nothing is that simple in the brain. Which type of channel is c... The local influx of calcium we have observed in spines is a fundam...,Scientists,reveal,details,of,brain,cell,communication:,implications,for,learning,&,memory,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Animals and plants need to know what is happening throughout their organism. For that an organised communication system is needed, so that the body or the plant knows what is happening all the way out in the...
Surface receptors are integral membrane proteins to which certain signal molecules bind. They generally span the cell membrane, connecting the outside of the cell with the inside, enabling the inner workings of the cell to sense and respond to signals outside of the cell. Each surface receptor is specific with respect to the compound or compounds it will bind; a molecule that can bind to a given receptor is called a ligand for that receptor. When a ligand binds to its surface receptor, the internal portion of the receptor becomes modified in some manner, effectively communicating to the cell that the ligand is present. This then elicits some type of response, such as chemotaxis. ■ chemotaxis, p. 65. Cells can alter the types of surface molecules they make, enabling them to respond only to signals that are relevant when the cell is in a certain location or developmental stage. For example, a dendritic cell in the tissues would respond differently to certain stimuli than one that has migrated to ...
Signal transduction is a way that cells talk to one another. Cells communicate to coordinate what they do. They might be a group of cells al...
Biology Animations includes selected, high quality biological animations; about cell biology, microbiology, genetics, immunology, cancer treatments and diagnosis.... ...
Conjugation, the transfer of DNA by direct cell-to-cell contact, depends on the presence of a conjugative plasmid(is small, double-stranded DNA molecules
A senior investigator and former director of the SLRI, Dr. Pawsons work has had a profound impact on biomedical research. His ground-breaking studies have focused on the signals that are transmitted between cells in the human body and how this forms a pattern of communication. By understanding cellular communication, scientists can track how the patterns of communication can "break down" in conditions such as heart disease and immune system deficiencies ...
SUAREZ, Jorge E. y BRAVO, Alicia I.. Conexins and the Cardiovascular System. Rev. argent. cardiol. [online]. 2006, vol.74, n.3, pp. 149-156. ISSN 1850-3748.. Intercellular communication is an essential biologic event of multicellular organisms and is associated with cell growth and differentiation control, apoptosis, adaptive responses of differentiated cells and the synchronization of cellular functions. A kind of intercellular junctions known as gap junctions, actively participate in these processes and are structurally made of conexins. From a cardiovascular viewpoint, cell to cell communication, under normal conditions, is essential in cardiac embryogenesis, electrical impulse transmission, synchronization of cardiac contractile activity, transmission of vascular reflex signals and other biological functions. Under pathological conditions, either by inherited or acquired genetic mutation, intercellular communications participate in the development of congenital cardiopathies, ...
O-Glycosylation in general has impact on a diversity of biological processes covering cellular aspects (targeted transport of glycoproteins), molecular aspects (protein conformation, resistance to proteolysis), and aspects involved in cellular communication (cell-cell and cell-matrix interaction ...
Regenerative Medicine, Cell Bilology. With the recent progress in organ transplantation technology and stem-cell research, the practical application of regenerative therapy using stem cell-derivatives has come to public attention. To increase the feasibility of this new concept, however, kinetics and the functional expression of engrafted cells should be strictly controlled in well- organized 3-D tissues. So far, many researches have elucidated part of molecular mechanisms underlying the tissue morphogenesis to accumulate background information for successful cell transplantation. They include: 1) how nascent cells differentiate into functional ones;2) how they establish the proper polarity and the cell-cell junctional apparatus that enable cellular communications,;3) how they arrange functional multicellular structures; and 4) how they determine the overall size and control the shape of the tissue. All such dynamic cellular behaviors are known to be directed by the concerted action of many ...
Antigen based immunotherapeutics aim to rehabilitate the immune system and prepare the human body to concur disease. Key factor in this biological process is the immune response via dendritic cells (DCs) that either turn on the immune response or actively dampen unwanted immune inflammation. Current antigen based therapies however still lack an effective response which is potent, antigen specific and durable, and can also rely on a favorable safety profile. Therefore, there is a clear need for improvements in this therapeutic class. GlycoDCTM dendritic cell targeting technology. The core of DC4Us proprietary GlycoDCTM technology is glycation of antigens to which we direct the immune response. Glycans are complex carbohydrate structures that form recognition elements for glycan-specific receptors that, upon recognition, mediate cellular communication. The immuno-therapeutics that can be developed using the GlycoDCTM technology, are exceptional because they are potent, specific, durable, ...
In a mobile cellular communication system, adjacent basestations BS1-BS4 are assigned different selections of different frequency channels to communicate with mobiles in their cells (10, etc.). To improve system quality and capacity, a basestation selects a frequency channel which is not assigned to it or any neighbour station, and makes test communications on that frequency channel with mobiles (e.g. MS1) in its cell. The basestation assesses the potential performance of that frequency channel, and neighbour basestations can monitor for potential interference on that frequency channel. The information so gathered can be analysed by an operations maintenance station OMC.
Cusabio offers CD8B related Antibodies, Proteins, cDNA and ELISA Kits. We also illustrate the related signaling pathways covering most research areas so that you can know the internal cellular communication. Some free antibody samples are given away in times.
Cusabio offers MS4A1 related Antibodies, Proteins, cDNA and ELISA Kits. We also illustrate the related signaling pathways covering most research areas so that you can know the internal cellular communication. Some free antibody samples are given away in times.
Video Domains miniature DVR with cellular communications is a finalist in IFSEC 2007 Security Innovations Awards. The DV-58/CELL is a stand-alone, miniature DVR integrating Cellular Technology,...
PhD Project - Biochemistry of cell-cell communication: revealing how signalling proteins move and interact in the extracellular space at University of Leeds, listed on FindAPhD.com
In a finding that directly contradicts the standard biological model of animal cell communication, UCSF scientists have discovered that typical cells in animals have the ability to transmit and receive biological signals by making physical contact with each other, even at long distance.
Calcium, Cell Communication, Communication, Concentration, Connexins, Diseases, Gap Junction, Ions, Isoforms, Membrane, Membrane Potential, Mutations, Pharmacology, Second Messengers, Therapeutic
The interaction between the brain and the gut has been recognized for many centuries. This bidirectional interaction occurs via neural, immunological and hormonal routes, and is important not only in...
Cell to cell communication is essential for the co-ordination of responses in all multicellular organisms. Research in the Faulkner lab addresses how…
Cytokines are a family of proteins that play important roles in immune cell communication. The best-known example is interleukin-2 (IL-2), which is ...
|strong||em|Result|/em||/strong|: Dramatically betters cell communication, nerve impulses, & liver bile detox. |strong||em|Benefit|/em||/strong|: ...
Mei, Yu; Du, Ziming; Hu, Changchen; Greenwald, Noah F.; Abedalthagafi, Malak; Agar, Nathalie Y.R.; Dunn, Gavin P. et al. (Cell Communication and Signaling : CCS, 2017) Link to Published Version ...
A Networking Paradigm Inspired by Cell Communication Mechanisms: 10.4018/978-1-4666-5125-8.ch002: This chapter provides a brief review of molecular communication, a networking paradigm inspired by cell communication mechanisms. In molecular communication
Using an in vitro model in which a confluent monolayer of capillary endothelial cells is mechanically wounded, gap junction-mediated intercellular communication has been studied by loading the cells with the fluorescent dye, Lucifer Yellow. Approximately 40-50% of the cells in a nonwounded confluent monolayer were coupled in groups of four to five cells (basal level). Basal levels of communication were also observed in sparse and preconfluent cultures, but were reduced in postconfluent monolayers. 30 min after wounding, coupling was markedly reduced between cells lining the wound. Communication at the wound was partially reestablished by 2 h, exceeded basal levels after 6 h and reached a maximum after 24 h, at which stage approximately 90% of the cells were coupled in groups of six to seven cells. When the wound had closed (after 8 d), the increase in communication was no longer observed. Induction of wound-associated communication was unaffected by exposure of the cells to the DNA synthesis ...
The researchers believe targeting the mechanism may lead to new therapies for the symptoms of motor neurone disease.. Otago neurobiologist Associate Professor Ian McLennan and his Aberdeen colleagues have discovered that a protein known as transforming growth factor beta 2 (TGF-β2) appears to regulate how motor neurons send signals to neighbouring brain cells.. Their findings are newly published in the prestigious US journal Proceedings of the National Academy of Sciences (PNAS).. Associate Professor McLennan says the discovery of the TGF-β2proteins previously invisible role in regulating brain cell communication surprised the team.. "We did not predict this, and the finding fundamentally alters our understanding of how communication between cells in the brains motor system is controlled. It is also likely that this mechanism plays a role in other brain signalling systems.". Historically it was thought that the information flow from cell to cell was controlled by the number of quanta, or ...
Model of the role of FGF in establishing regional differences in gap junction-mediated intercellular communication in the lens. (A) The concentration of FGF i
16.07.2013 Researchers at Johannes Gutenberg University Mainz (JGU) have discovered a new form of communication between different cell types in the brain. Nerve cells interact with neighboring glial cells, which results in a transfer of protein and genetic information. Nerve cells are thus protected against stressful growth conditions. The study undertaken by the Mainz-based cell biologists shows how reciprocal communication between the different cell types contributes to neuronal integrity. Their results have been recently published in the journal PLOS Biology. Brain function is determined by the communication between electrically excitable neurons and the surrounding glial cells, which perform many tasks in the brain. Oligodendrocytes are a type of glial cell and these form an insulating myelin sheath around the axons of neurons. In addition to providing this protective insulation, oligodendrocytes also help sustain neurons in other ways that are not yet fully understood. If this support ...
Abstract :. The development and function of multicellular organisms relies on the ordered communication of cells that function in networks and circuits. Our understanding of cellular communication and its physiological consequences hinges on the ability to modulate specific signals while monitoring effects in intact tissues and behaving animals. In our laboratory, we combine synthetic biology and cell biology to modulate the communication between cells and ultimately intervene with physiology. To achieve this goal, we re-engineer molecular components of the mammalian cellular communication machinery, currently in particular those components that control cell survival, to be responsive to new synthetic stimuli. These stimuli are novel ligands or, more recently, light in optogenetics, which offers control in space and time. For instance, we have recently developed receptor tyrosine kinases, such as the receptors for neurotrophic factors or EGF, that are activated by blue or red light in the ...
The strained relationship between Bradenton Beach and the Center for Municipal Solutions came to an end Feb. 8 with notification the city will repeal its cellular communications tower ordinance.. CMSs Lawrence "Rusty" Monroe and the city have been feuding for months over language in the ordinance drafted by Monroe and adopted May 5, 2011, under former Mayor Bob Bartelts administration.. As the city moved forward with discussions on installing a cellular communications tower near the public works facility last year, Commissioner Ric Gatehouse observed several issues in the ordinance he found objectionable.. The relationship between the city and Monroe became brittle and shattered at one point, with Monroe withdrawing - saying he would take his ordinance with him.. Monroe said the city had no rights to use his ordinance without agreeing to pay exclusive application review fees to his company, as per the original agreement outlined in his ordinance.. Gatehouse initially wanted the ordinance ...
We have identified the liver-regulating protein (LRP), a cell surface protein involved in the maintenance of hepatocyte differentiation when cocultured with rat liver epithelial cells (RLEC). LRP was defined by immunoreactivity to a monoclonal antibody (mAb L8) prepared from RLEC. mAb L8 specifically detected two polypeptides of 85 and 73 kD in immunoprecipitation of both hepatocyte- and RLEC-iodinated plasma membranes. The involvement of these polypeptides, which are integral membrane proteins, in cell interaction-mediated regulation of hepatocytes was assessed by evaluating the perturbing effects of the antibody on cocultures with RLEC. Several parameters characteristic of differentiated hepatocytes were studied, such as liver-specific and house-keeping gene expression, cytoskeletal organization and deposition of extracellular matrix (ECM). An early cytoskeletal disturbance was evidenced and a marked alteration of hepatocyte functional capacity was observed in the presence of the antibody, ...
The review describes the role of cells of extracellular matrix (ECM) as a source of neoplastic outgrowths additional to the original tumour. The cells undergo a spontaneous transformation or stimulation by the original tumour through intercellular signals, e.g. through Shh protein (sonic hedgehog). Additionally, cells of an inflammatory infiltrate, which frequently accompany malignant tumours and particularly carcinomas, may regulate tumour cell behaviour. This is either by restricting tumour proliferation or, inversely, by induction and stimulation of the proliferation of another tumour cell type, e.g. mesenchymal cells. The latter type of tumour may involve formation of histologically differentiated stromal tumours (GIST), which probably originate from interstitial cells of Cajal in the alimentary tract. Occasionally, e.g. in gastric carcinoma, proliferation involves lymphoid follicles and lymphocytes of GALT (gut-associated lymphoid tissue), which gives rise to lymphoma. The process is ...
Clone REA718 recognizes the human integrin β5 antigen, a 95 kDa glycoprotein single-pass type I membrane protein. Integrins are a family of transmembrane receptors that mediate adhesion of cells to extracellular matrices, as well as intercellular interactions. These interactions transduce signals that control complex cell functions such as proliferation, differentiation, and survival, and require the regulation of gene expression. Integrins are heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. The integrin αV/β5 heterodimer is found on many types of tissue cells, such as epithelial cells, endothelial cells, keratinocytes, and osteoblastic cells. It is a receptor for fibronectin and vitronectin and acts as a receptor for adenovirus type C. Additional information: Clone REA718 displays negligible binding to Fc receptors. - Nederland
Clone REA718 recognizes the human integrin β5 antigen, a 95 kDa glycoprotein single-pass type I membrane protein. Integrins are a family of transmembrane receptors that mediate adhesion of cells to extracellular matrices, as well as intercellular interactions. These interactions transduce signals that control complex cell functions such as proliferation, differentiation, and survival, and require the regulation of gene expression. Integrins are heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. The integrin αV/β5 heterodimer is found on many types of tissue cells, such as epithelial cells, endothelial cells, keratinocytes, and osteoblastic cells. It is a receptor for fibronectin and vitronectin and acts as a receptor for adenovirus type C. Additional information: Clone REA718 displays negligible binding to Fc receptors. - Lëtzebuerg
The global 3D cell culture market is anticipated to reach USD 1.69 billion by 2024, according to a new report by Grand View Research, Inc. Potential of this technology to replace and reduce the usage of animal models for histological analysis and biochemical assays is expected to fuel demand for 3D cell culture products thus driving growth in the coming years.. Advent of technology with respect to spheroid formation and matured assay methods is expected to boost the emergence of 3D optimized assays, kits, and protocols, in turn, expediting the entire research process. In addition, the scope of three-dimensional (3D) cell culturing experiments for evaluation of drug moiety is anticipated to grow owing to advantages associated with its usage. These advantages include increased cell to extra cellular matrix (ECM) as well as intercellular interactions, variation in the proliferation zones, ease for analyzing impact of site-specific stromal tissue components in the tumor microenvironment.. Research ...
Hypoxia is a key factor that accompanies most brain pathologies, including ischemia and neurodegenerative diseases. Reduced oxygen concentration results in irreversible changes in nerve cell metabolism that entails cell death and destruction of intercellular interactions. Since neural networks are responsible for the processing, storage and transmission of information in the brain, the loss of network elements can lead to dysfunction of the central nervous system and, consequently, the development of neurological deficiency and the patients severe disability.. This is the reason why the worlds neurobiological community is currently involved in an active search for compounds that can prevent the death of nerve cells and support their functional activity under stress.. According to Maria Vedunova, Director of the Institute of Biology and Biomedicine at Lobachevsky University (UNN), the Institutes researchers propose to use the bodys own potential to combat hypoxia and its consequences.. "Our ...
The purpose of this study was to examine student influence upon the teacher within the context of a bidirectional model of interaction. The possibility of using the teachers motivational structure as a means of explaining and predicting the occurence of student influence was also considered. -- The theoretical framework for the study was developed from a review of the literature. The key components of the model were: the teachers predispositions, including their motivational structure, the objective situation, and the definition of the situation. Presumably, the teachers behavior would be controlled by their definition of the situation, which would be a function of the predispositional structure and the objective situation. -- The interaction between the teacher and the students in three elementary classrooms was studied. These teachers were chosen from a sample of 54 teachers, who had first been categorized into three groups, on the basis of a Q-Sort. Thus, there was one teacher to represent ...
Preface xi About the Authors xiii. 1 THE CELLULAR ORIGIN OF VERTEBRATES 1. The Origins of Unicellular Life on Earth 1. Prokaryotes versus Eukaryotes 4. Coevolution of traits 5. Cholesterol Facilitates Lipid Rafts for Cell-Cell Communication 7. The Endomembrane System 9. The Cellular Mechanism of Evolution 10. Why Evolve? 11. Cell-Cell Communication and Aging 12. 2 REDUCING LUNG PHYSIOLOGY TO ITS MOLECULAR PHENOTYPES 17. Hormonal Acceleration of Lung Development 17. Neutral Lipid Traffi cking and Lung Evolution 19. Other Examples of Cellular Cooperativity 23. Summary 24. 3 A CELL-MOLECULAR STRATEGY FOR SOLVING THE EVOLUTIONARY PUZZLE 25. Rationale for Cell-Molecular Evolution 25. Mechanism of Mammalian Lung Development 28. Avian Lung Structure-Function Relationship: The Exception that Proves the Rule 32. Does Ontogeny Recapitulate Phylogeny? The Role of PTHrP in Lung Development 32. Interrelationship between PTHrP, Development, Physiology, and Repair: Is Repair a Recapitulation of Ontogeny and ...
Bacterial mating or conjugation is the transfer of DNA from one bacterium to another via direct cell-to-cell contact through a mating pore. My current research uses the genetically-tractable bacterium Bacillus subtilis as a model system to explore the function and subcellular localization of a putative component of the bacterial mating pore apparatus. I have been characterizing the protein ConE (formerly YddE) which is encoded on the B. subtilis conjugal element ICEBs1. ConE is related to proteins encoded on conjugal elements in numerous bacteria, including the Gram-positive pathogens S. aureus, C. difficile, and L. monocytogenes. ConE belongs to a large superfamily of ATP-dependent pumps involved in the extrusion of proteins and DNA through membrane pores. I have shown that ConE and its ATPase domain are essential for mating of ICEBs1. In addition, ConE-GFP localizes at the cell poles, in close association with the membrane (see Figure). Given ConEs localization, ATPase domain, and ...
Bacterial mating or conjugation is the transfer of DNA from one bacterium to another via direct cell-to-cell contact through a mating pore. My current research uses the genetically-tractable bacterium Bacillus subtilis as a model system to explore the function and subcellular localization of a putative component of the bacterial mating pore apparatus. I have been characterizing the protein ConE (formerly YddE) which is encoded on the B. subtilis conjugal element ICEBs1. ConE is related to proteins encoded on conjugal elements in numerous bacteria, including the Gram-positive pathogens S. aureus, C. difficile, and L. monocytogenes. ConE belongs to a large superfamily of ATP-dependent pumps involved in the extrusion of proteins and DNA through membrane pores. I have shown that ConE and its ATPase domain are essential for mating of ICEBs1. In addition, ConE-GFP localizes at the cell poles, in close association with the membrane (see Figure). Given ConEs localization, ATPase domain, and ...
In the present work, we report evidence that in addition to its role on the proliferation of pancreatic progenitor cells, the mesenchyme is crucial in controlling the timing of pancreatic β-cell differentiation. When we cultured rat embryonic pancreatic epithelium in the absence of its surrounding mesenchyme, we found that Ngn3 expression was turned on rapidly and then turned off a few days later, in keeping with the reported in vivo pattern (15,25). Our filter-separation experiments indicate that the mesenchyme-induced delay in Ngn3 induction requires direct contact between the epithelium and the mesenchyme. This result fits in with recent data indicating that direct cell-cell contact between epithelial and mesenchymal cells suppresses β-cell formation (26). We also found that Ngn3 expression occurred far earlier without mesenchyme, within a few hours compared with 3 days with mesenchyme either in vitro or in vivo. This acceleration in Ngn3 induction resembles the pancreatic phenotype of mice ...
The waves are said to be produced in direct response to the presence of epidermal growth factor (EGF), and last approximately 10 - 20 minutes before vanishing. Wave cells have become a hot topic of late, as researchers suspect that they play an important role in the transmission and regulation of normal cellular communication.. Under normal circumstances, waves are responsible for selectively collecting growth-promoting proteins and directing them into the inner structure of the cell. This process results in a reorganization of the cells outer infrastructure, where it forms a flexible foot-like structure (lamellipodia) which then allows the cell to move and dock with corresponding epidermal growth factor receptors (EGFR). Usually, the wave neutralizes or moderates the internalized growth protein, but in cancer cells, where the wave is either malfunctioning or not present, metastatic cancer occurs as a result of unregulated EGF and EGFR interaction.. "These findings have broad implications ...
Signal transduction is the molecular basis for cellular communication. Complex networks of intracellular molecules enable cells to receive signals from their environment and to modify their behavior in response to these signals. Signaling molecules are interconnected, and depending on how they are linked together they can form different types of networks. We have recently described a novel network of proteins that becomes activated by increases in cell sodium permeability and that regulates active sodium transport. Because each component of this sodium-sensing network so far described have been independently associated with multiple and essential cell functions, our work on the network topology and modeling is of importance because it will help us to understand the networks role and complexity when transforming the sodium signal into transcription activation and gene expression leding to changes in myocardial- and/or renal cells growth.. Also, understanding the function and relevance of the ...
Dr. John D. Scott, professor and chair of pharmacology at the University of Washington School of Medicine and a Howard Hughes Medical Institute Investigator, along with Dr. F. Donelson Smith of the UW and HHMI, led this study, which also involved Drs. Claire and Patrick Eyers and their group at the University of Liverpool.. The researchers explained that key cellular communication machinery is more regionally constrained inside the cell than was previously thought. Communication via this vital system is akin to social networking on your Snapchat account.. Within a cell, the precise positioning of such messaging components allows hormones, the bodys chief chemical communicators, to transmit information to exact places inside the cell. Accurate and very local activation of the enzyme that Scott and his group study helps assure a correct response occurs in the right place and at the right time. The inside of a cell is like a crowded city, said Scott, It is a place of construction and tearing ...
The platelet-derived growth factor-ß (PDGF-ß) intracellular signaling pathway has an established role in mediating cellular communication between endothelial and mural cells, which is essential for the normal formation of blood vessels. Dr. Weiss and colleagues have discovered that MT1-MMP, whose traditional role in endothelial and mural cells is to break down the proteins that reside in the spaces between cells, has an additional role in the regulation of PDGF-ß signaling ...
At the Redenti Lab, we are exploring cellular communication involved in the development and regeneration of retinal and other central nervous system tissue. We are particularly interested in how cells respond to morphogenetic fields of discrete, localized biochemical and electrical signals leading to the development of organized neural tissue. Read More ...
Mannatechs Ambrotose complex is the worlds first dietary supplement to combine a scientifically proven and standardized blend of plant sourced glyconutrients.. What are Glyconutrients?. Good question glad you asked. Glyconutrient saccharides make up what is called a Glycoprotein. These attach themselves to cell membranes massively increasing the cells abilities to talk to each other. Improving the efficiency of all the bodies systems.. O.K. thats the sciencey stuff out of the way so what does that actually mean for you and your familys health?. A lot. Third party clinical trials have shown that due to improved cellular communication, you get improved cognitive function. This means better memory and concentration. Improved moods and less irritability. Boosts to the immune system, and support for proper organ function. And a more efficient digestive system. Ambrotose complex helps you build a strong foundation for better wellbeing, at the cellular level.. Where does Mannatechs Ambrotose ...
Senior care service provider Cerna Home Care launched "Onhand Assistance" - a smartwatch especially designed for seniors. The stylish wearable device provides fall detection, fall notification, vitals monitoring, cellular communication, and medication reminders - in addition to life-saving calls and care. Every second an older adult fall, making falls the number one cause of injuries and deaths from injury among older Americans. In 2014 alone, 29 million falls among elderly Americans resulted in seven million injuries and costing an estimated $31 billion in annual Medicare costs, according to a new report published by the Centers for Disease Control and Prevention in this weeks Morbidity and Mortality Weekly Report (MMWR).. Onhand Assistance helps lessen the need for expensive personal caregivers and avoids time consuming ambulance trips to the hospital due to false alarms. Family members monitor their loved one through the Onhand Assistance smartphone app. Seniors, their friends and their ...
Dear Colleague,. As I write these words, the Mobile World Congress show is underway in Barcelona, Spain. At this yearly event, one of the most important cellular communications conferences, mobile handset and tablet manufacturers and their service provider partners reveal their latest and greatest offerings. And alongside them are the silicon and software providers, unveiling next-generation system building blocks which they hope will show up in handsets and tablets at next years MWC.. One of the biggest announcements coming out of this years show, at least so far, is Nokias model 808 PureView phone. Ive written many times in recent months about the potential for cameraphones to render standalone cameras obsolete, as well as about the notable embedded vision development potential implied in the burgeoning still and video image capture capabilities of mobile electronics devices. Although the Nokia 808 will probably not sell in large quantities, due both to its fairly high price point (450 ...
Gentaur molecular products has all kinds of products like :search , Prosci \ DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. DTX2 probably acts both as a positive and \ 29-852 for more molecular products just contact us
Cell to Cell Communication: Exosomes Exosomes are extracellular vesicles that can contain proteins, lipids, nucleic acids and sugars, and play a key role
In 1991, Fromhertz and company managed to get a simple electronic/ionic dialog going on between a silicon capacitor and a slug neuron - and when we say simple, we mean very, very simple: An electron-carrying signal was sent from a silicon-based capacitor, through an electrolyte, and across a 5nm cell membrane where it induced an ionic channel in the membrane that caused a replication of the pulse of the trigger signal from the chip.. If that last sentence confused you, dont fret - its both a complex concept to explain and a gross oversimplification of the methods used. The basic take-away: The chip could talk to the cell, and vice-versa. Not that they could say much. But, hey, you have to crawl before you can walk, right?. Importantly, Fromherzs chip/cell communication could be conducted with no corrosive nor electrochemical damage to either the chip or the cell. However, that slug-neuron success was the only giant step in the development of a chip/cell interface for 17 years. It was only ...
Investigators anticipate that cellular imaging techniques in a multiple sclerosis mouse model will enable them to identify the signaling that drives immune cell infiltration and inflammation in autoimmune multiple sclerosis (MS) and assess whether this signaling can be disrupted. MS is an autoimmune disease in which the bodys immune cells mistake nerve cells in the brain and spinal cord (the central nervous system, CNS) as foreign and attack them. The immune cells produce inflammation that destroys myelin, which is the fatty sheath that insulates nerve cell axons (the cells communication cables) and interrupts messages traveling from one nerve cell to another. Researchers have found that a molecule called "S1P" drives this inflammatory process in MS. The molecule signals immune cells to travel to the CNS and attack. A drug called Gilenya that blocks S1P signaling was recently approved by the federal Food and Drug Administration to treat MS. While Gilenya is extremely effective in treating MS ...
The research in our group focuses on the structural biochemistry and biophysics of membrane proteins. Membrane proteins perform most of the important processes in all living cells. For example, respiration, photosynthesis, cell communication, cell import/export, cell growth and recognition are catalyzed and regulated by membrane proteins. These proteins do not act in an isolated way; they rather perform communication within the cell by binding and releasing of cofactors and soluble signal-transducing proteins. Membrane proteins are also key player in infectious diseases as they mediate entry of viral and bacterial pathogens into the host cell and also play an important role in the cell defense against the pathogens.. The main step for the elucidation of the complex in whole living cells is the understanding of the structure, dynamics and function of the membrane proteins that play the key role in these processes. Our research field is of a very interdisciplinary nature and includes biochemical ...
Age-related cognitive decline tied to immune-system molecule A blood-borne molecule that increases in abundance as we age blocks regeneration of brain cells and promotes cognitive decline. The molecule in question, known as beta-2 microglobulin, or B2M, is a component of a larger molecule called MHC I, which plays a major role in the adaptive immune system. A growing body of research indicates that the B2M-MHC I complex, which is present in all cells in the body except red blood cells and plasma cells, can act in the brain in ways not obviously related to immunity--guiding brain development, shaping nerve cell communication, and even affecting behavior ...
Cancer cells exhibit many defects in cell communication that contribute to the loss of tissue homeostasis (excess cell proliferation, invasion, and metastasis). The process of cancer formation causes a disruption in cell ...
Research conducted in our laboratory focuses on the fundamental aspects of fluid mechanics and mass transport that are involved in the modulation of mammalian cell function. Special attention is given to the cells in the arterial circulation and to the development of tissue-engineered vascular implants.. Our research activities include the development of instrumentation and methods for the accurate in vitro evaluation of cell function in variable mechanical environments. A main objective is to develop experimental models and theoretical analysis that will provide a good description of the dynamic process occurring in the arterial surface in early atherosclerosis. We are interested in the identification of physical mechanisms involved in cell pathobiology. In specific, we study cell communication, adhesion and injury in well controlled disturbed flow fields in vitro.. Three dimensional numerical simulations of the fluid flow in models of graft anastomosis and arterio-venous reconstructions are ...
Mueller, Rolf; Herr, Claudia; Sukumaran, Salil K.; Omosigho, Napoleon Nosa; Plomann, Markus; Riyahi, Tanja Y.; Stumpf, Maria; Swaminathan, Karthic; Tsangarides, Marios; Yiannakou, Kyriacos; Blau-Wasser, Rosemarie; Gallinger, Christoph; Schleicher, Michael; Kolanus, Waldemar; Noegel, Angelika A. (2013): The cytohesin paralog Sec7 of Dictyostelium discoideum is required for phagocytosis and cell motility. In: Cell Communication and Signaling 11 [PDF, 2MB] ...
Provides fundamental knowledge of cell-to-cell interactions necessary for proper development and organization of the nervous system. Topics include pattern formation, neuronal differentiation, axon guidance, and target interactions. Prerequisite: Permission of the Instructor. Alternate years ...
Signal transduction pathways using a variety of second messengers have been well documented in animal systems. Some of the most common second messengers are 3′,5′-cyclic AMP (cAMP), G-proteins, 1,2 diacylglycerol (DAG), inositol 1,4,5-triphosphate (IP3), and Ca2+, and many of these have been shown to be active in plants. When a chemical messenger such as a hormone binds to a membrane receptor, one or more of these second messengers are elevated ...
Microcurrent is naturally generated in the body to produce the energy required for muscle movement and nerve impulses. It is the bodys own electrical system that provides the voltage for ionic exchanges across the cell membranes allowing for cell functions including the intake of nutrients from the blood, removal of cellular waste and movement of impulses along nerve pathways. The harmonious flow of these tiny electrical signals is also essential for healthy cell function and cell-to-cell communication. In the event of injury or disease there is signal disruption that obstructs the pathways of intercellular communication. No Pain, No Soreness, No Abrasions, No Side Effects, No Redness and No Downtime. Check contraindications like pace maker, etc. ...
Working from recently published NCA journal articles and emerging research and perspectives, Communication Currents explains scholarly information in straightforward language geared for broad audiences, including communication experts working with laypeople, instructors and students, the press, and other interested members of the public. Communication Currents highlights the relevance of Communication scholarship, reveals the ways in which communication impacts our world, and demonstrates the leadership of NCA in the study of Communication.. ...
Health,Hospitals that use a simple strategy of enhancing communication with f...The multicenter trial found that family members who engaged in a...The study included family members of 126 patients dying in 22 IC...The huge effect of the intervention is surprising says lead res...The 15-page leaflet used in the study describes and explains end...,Improved,Communication,may,Help,to,Accept,the,Death,of,Loved,Ones,With,Poise,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
An organic electronic device comprising at least two segments, each segment comprising an organic electronic light-emitting device defined by peripheral edges ; wherein each segment comprises a first electrical contact disposed on a first peripheral edge and a second electrical contact disposed on a different peripheral edge than the first electrical contact and the electrical contacts of the segments are joined in electrical communication with a conductive material, preferably each segment comprises a continous substrate layer and subsrate layer is discontinuos between segments.
Glycoproteins are molecules containing sugar and protein, which permit healthy cell-to-cell communication in the human body. Babies receive glycoproteins...
Analysis of the T cell network. (a) The T cell network [24]. The channel input molecules are TCR lig, CD4 and CD28, whereas the output molecules are AP1, bcat,
Have you ever wondered, how do cells talk with each other or how do they communicate? How do they come to know what has to be done if you get hurt or if you are hungry or thirsty? Isnt it very interesting to know that all types of cell receive information and respond to signals from their environment. But you might be wondering, how? The answer is through Signaling Molecules which play a lead role in this process of cell-cell communication. Now, you might be thinking, what are these signaling molecules? Where do they come from? How do they work? Ok..lets understand all about signaling molecules. These signaling molecules are basically chemicals (like nitric oxide etc.) or proteins (hormones etc.) which are secreted or expressed on the surface of the cell. They then bind to receptors which are present on the other cell (these cells are called target cell) or sometimes even present on the same cell; thereby coordinating the functions of various cells. The binding of these signaling molecules on ...
International Media Communication in a Global Age (Routledge Communication Series) en Iberlibro.com - ISBN 10: 0415999006 - ISBN 13: 9780415999007 - Routledge - 2009 - Tapa blanda
Spaeth Communications, Inc. is a strategic consulting, training and crisis communication firm. Recognized internationally for its unique methodology, Spaeth defines communication as influence.
Our integrated circuits and reference designs for the control and communication module of three phase UPS help you design reliable and robust hardware for sensing, controlling and communicating with three phase UPS systems. Control and communication module for three phase UPS designs often require:
Show that youve implemented best practices for patient financial communications. Let HFMA recognize your organization as a Patient Financial Communications Adopter.
Following an EMP, all communications were familiar with will be dead. Learn how to protect your emergency communications from the effects of an EMP.
Listening and asking questions promotes relationships and communication. Learn to listen and ask questions for clarification and greater understanding.
Listening and asking questions promotes relationships and communication. Learn to listen and ask questions for clarification and greater understanding.
Learn how to define, implement, configure and host a Windows Communication Foundation (WCF) service and then consume the service in a client.
το κείμενο με τίτλο THREE TOPICS IN PARALLEL COMMUNICATIONS σχετίζετε με Λογισμικό & κατασκευή λογ/κού
... In reference to Verizons competitors, is Verizon the price leader? If not, who is? Is Verizons pricing at the skimming (high) or penetration (low) level? Provide rationale for your.
Receptor activator of NF-kappaB ligand (RANKL) is crucial in osteoclastogenesis but signaling events involved in osteoclast differentiation are far from complete and other signals may play a role in osteoclastogenesis. A more direct pathway for cellular crosstalk is provided by gap junction intercellular channel, which allows adjacent cells to exchange second messengers, ions, and cellular metabolites. Here we have investigated the role of gap junction communication in osteoclastogenesis in mouse bone marrow cultures. Immunoreactive sites for the gap junction protein connexin 43 (Cx43) were detected in the marrow stromal cells and in mature osteoclasts. Carbenoxolone (CBX) functionally blocked gap junction communication as demonstrated by a scrape loading Lucifer Yellow dye transfer technique. CBX caused a dose-dependent inhibition (significant , or = 90 microM) of the number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells formed in 7- to 8-day marrow cultures ...
This Research Topic addresses the emerging role of extracellular vesicles in cellular communications and immune responses. We will emphasize their use as biomarkers (research tool to better understand extracellular vesicle functions) and immune modulators (therapeutic tool to suppress or enhance immune responses). Extracellular Vesicles (EVs) are released in response to signals activating their parental cells. They are divided in two categories: small EVs (e.g. exosomes) and large EVs (e.g. microvesicles/ectosomes/microparticles). Small and large EVs differ in terms of size, release and budding mechanism, lipid and protein composition, and surface antigens. Research findings from the last decade suggest that EVs have an important, yet not completely understood, role in cell-cell communication. They can influence neighboring cells, act in an autocrine or paracrine manner, affect tumor growth, de novo-angiogenesis, and immunological functions. EVs are a novel and important tool to impact cell function and
Gap junctions are clusters of specialized intercellular channels that regulate the direct exchange of ions and various hydrophilic cellular metabolites that are smaller than 1000 Da, a process known as gap junctional intercellular communication (GJIC) (Alexander and Goldberg, 2003). Two inter-docked connexons (hemichannels), one from each of two apposing cells, form a functional gap junction channel. Each connexon is composed of six oligomerized connexin (Cx) subunits, and, to date, the connexin family consists of 21 members in human (Söhl and Willecke, 2003; Söhl and Willecke, 2004). Interestingly, the primary function of gap junction channels is to facilitate intercellular communication; however, hemichannels have also been reported to exist and function at the cell surface in an undocked state, permitting the transfer of molecules between extracellular and intracellular environments (Anselmi et al., 2008; Burra and Jiang, 2011; Tong et al., 2007). Hemichannels that are formed from single or ...
Founder cells for most early lineages of the sea urchin embryo are probably specified through inductive intercellular interactions. It is shown here that a complete respecification of cell fate occurs when 16-cell stage micromeres from the vegetal pole of a donor embryo are implanted into the animal pole of an intact recipient embryo. Animal pole cells adjacent to the transplanted micromeres are respecified from presumptive ectoderm into vegetal plate founder cells. These induced vegetal plate cells express the entire battery of genes characteristic of the endogenous vegetal plate cells. The ectopic vegetal plate invaginates during gastrulation to form a second archenteron which differentiates properly into a tripartite gut, as shown by the spatial pattern of expression of an endoderm-specific marker gene. Thus, transplanted micromeres can signal neighboring cells to induce them to change their fate. ...
Intercellular communication through gap junctions is crucial for proper functioning of the inner ear. Indeed, mutations in several connexin genes have been found to cause hearing loss. In the inner ear, only the cell distributions of connexin30 and connexin26 have been well documented. We took advantage of the lacZ reporter gene in Cx43 and Cx45 knock-out mice to study the expression of the connexin43 and connexin45 genes during the inner ear development. Expression of Cx43 and Cx45 in the inner ear was detected from embryonic days 15.5 and 17.5, respectively. Until the 1st week of life, Cx43 was highly expressed in the connective tissues, and weakly expressed in the immature sensory epithelium of the cochlea. From postnatal day 8, however, Cx43 was almost exclusively expressed in the bone of the otic capsule. During embryogenesis, Cx45 was expressed in epithelial and connective inner ear tissues. From birth onwards, Cx45 expression could be detected in some inner ear capillaries. Vascular expression
Mol Hum Reprod. 2014 Jan 26. [Epub ahead of print] Chang HM, Cheng JC, Taylor E, Leung PC. Author information Abstract In the ovary, connexin-coupled gap junctions in granulosa cells play crucial roles in follicular and oocyte development as well as in corpus luteum formation. Our previous work has shown that theca cell-derived bone morphogenetic protein (BMP)4 and BMP7 decrease gap junction intercellular communication (GJIC) activity via the down-regulation of connexin43 (Cx43) expression in immortalized human granulosa cells. However, the effects of oocyte-derived growth factors on Cx43 expression remain to be elucidated. The present study was designed to investigate the effects of oocyte-derived growth differentiation factor (GDF)9 and BMP15 on the expression of Cx43 in a human granulosa cell line, SVOG. We also examined the effect relative to GJIC activity and investigated the potential mechanisms of action. In SVOG cells, treatment with BMP15 but not GDF9 significantly decreased Cx43 mRNA ...
Communication between AEC I and AEC II can be accomplished by means of two major routes: gap junction and paracrine communication (Koval, 2002). What are the mechanisms for P2X7R-mediated AEC I and AEC II communication? Cell-to-cell contact and/or gap junction communication as a major mechanism is unlikely given that the gap junction blocker β-glycyrrhetinic acid did not block BzATP-stimulated surfactant secretion. Furthermore, the conditioned medium from BzATP-stimulated E10 or HEK-P2X7R cells showed that there was a stimulation of surfactant secretion comparable with that seen during the co-culture of these cells with AEC II. Thus, the release of soluble factors from AEC I upon the activation of P2X7R is probably responsible for AEC I and AEC II communication. One such factor is ATP. Indeed, P2X7R activation in the heterocellular culture of AEC I and AEC II caused release of ATP into the bulk milieu, which was blocked by BBG. This effect was completely absent in the AEC II monoculture. The ...

Frontiers of Biomedical Engineering
 | Open Yale CoursesFrontiers of Biomedical Engineering | Open Yale Courses

Cell Culture Engineering (cont.) Lecture 7 Cell Communication and Immunology Lecture 8 Cell Communication and Immunology (cont ... Human Physiology: From Cells to Systems, 5th edition. Belmont, California: Brooks/Cole, 2004. ...
more infohttp://oyc.yale.edu/biomedical-engineering/beng-100

James Haorah | Biomedical EngineeringJames Haorah | Biomedical Engineering

... impairs the transport of essential nutrients into the brain that interrupts the energetic communication of neuro-glial cells, ... 2005):Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction. J. Leuk. Biol. 78: ... Our hypothesis is that oxidative damage of the BBB interface facilitates immune cell infiltration, neuroinflammation and ... brain endothelial cells - the blood-brain barrier, pericytes, astrocytes, microglia, and neurons). His main focus is to examine ...
more infohttps://biomedical.njit.edu/people/jhaorah.php

Inside Rensselaer, May 27, 2011: Biomedical Engineering Students Win NSF FellowshipsInside Rensselaer, May 27, 2011: Biomedical Engineering Students Win NSF Fellowships

She will use the grant to advance her research using stem cells to regrow and repair bone and cartilage.. "NSF Graduate ... Inside Rensselaer, Strategic Communications and External Relations. 1000 Troy Building, 110 Eighth Street, Troy, N.Y. 12180 or ...
more infohttp://www.rpi.edu/about/inside/issue/v5n10/nsf.html

Suffolk University biomedical engineeringSuffolk University biomedical engineering

... cells are composed of carbon-rich polymers and can be tailored to enhance a specific function of the solar cell, such as ... L-3 Communications. The L-3 Aeromet Signal Processing Engineer is responsible for image processing and metric data analysis. ... Solar Cell Technology Program. The Office of Energy Efficiency and Renewable Energy (EERE) leads public research in innovative ... Stem cell research offers new hope in the areas of cancer treatment as well as life extension. The regulation of genetic ...
more infohttp://www.suffolkuniversity.org/Suffolk-University-biomedical-engineering.php?cat=BCF251ED

Cell-to-Cell Communication in FungiCell-to-Cell Communication in Fungi

... animal cells use gap junctions which are symplasmic connections through which molecules can diffuse from one cell to another. ... Cell-Cell Communication During Development. Type and Complexity of Pores. Variations in cell-cell communication can be ... Cell-to-Cell Communication in Fungi. News-Medical. https://www.news-medical.net/life-sciences/Cell-to-Cell-Communication-in- ... Cell-to-Cell Communication in Fungi. News-Medical. 19 September 2019. ,https://www.news-medical.net/life-sciences/Cell-to-Cell ...
more infohttps://www.news-medical.net/life-sciences/Cell-to-Cell-Communication-in-Fungi.aspx

Journal of Cell Communication and Signaling | Submission guidelinesJournal of Cell Communication and Signaling | Submission guidelines

... that provided the cells), cell type, number of cell line, and batch of cells. ... Cell lines. If human cells are used, authors must declare in the manuscript: what cell lines were used by describing the source ... whether the cell line has recently been authenticated and by what method. If cells were bought from a life science company the ... Personal communications and unpublished works should only be mentioned in the text. Do not use footnotes or endnotes as a ...
more infohttps://www.springer.com/journal/12079/submission-guidelines?utm_source=springer&utm_medium=referral&utm_content=null&utm_campaign=SRBM_3_ym_JSC_CellBiol_12079_pp

Cell-cell communication in carcinogenesis.  - PubMed - NCBICell-cell communication in carcinogenesis. - PubMed - NCBI

Cell-cell communication in carcinogenesis.. Trosko JE1, Ruch RJ.. Author information. 1. Department of Pediatrics and Human ... Normal homeostatic control of these three forms of cell communication determines whether: (a) the cell remains quiescent (Go ... Interestingly, cancer cells have been characterized as cells: (a) having been derived from a stem-like cell; (b) without their ... exceptions are free-standing cells such as red blood cells, neutrophils, and several, if not all, the stem cells). On the other ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/9458335?dopt=Abstract

Scientists Bridge Gap In Cell Communication | EurekAlert! Science NewsScientists Bridge Gap In Cell Communication | EurekAlert! Science News

The discovery is important because it adds essential information to the understanding of how cells relay molecular messages, a ... University of Wisconsin-Madison scientists have found a critical step in communication between cells that promotes such things ... Communication -- or miscommunication -- between cells is the basis for many diseases. For example, in humans it is believed ... A critical step in communication between cells that promotes such things as bone formation, limb growth, and the development of ...
more infohttps://eurekalert.org/pub_releases/1997-07/UoW-SBGI-160797.php

Cell communication in tissue P systems: universality results | SpringerLinkCell communication in tissue P systems: universality results | SpringerLink

... an evolution-communication model for tissue P systems where communication rules are inspired by the general mechanism of cell ... communication based on signals and receptors: a multiset can... ... Cell communication in tissue P systems and cell division in ... The universality for all these variants of tissue P systems is then proved by using two cells (three cells in the case of ... an evolution-communication model for tissue P systems where communication rules are inspired by the general mechanism of cell ...
more infohttps://link.springer.com/article/10.1007%2Fs00500-004-0393-4

Researchers Uncover Critical Player in Cell CommunicationResearchers Uncover Critical Player in Cell Communication

... by Medindia Content Team on October 8, 2006 at 4:45 AM Research News ... "TFII-I may be a universal player in communication between cells, in the brain, the immune system and elsewhere." Source: ... Called TFII-I, or TF "two eye," the protein long known to help control a cells genes also controls how much calcium a cell ... Knocking down TFII-I and separately assaulting the cells with chemicals caused the cells to take up more calcium than usual. ...
more infohttps://www.medindia.net/news/view_news_main.asp?x=14892

Evidence found for novel brain cell communication - ScienceBlog.comEvidence found for novel brain cell communication - ScienceBlog.com

New research suggests evidence for a novel type of communication between nerve cells in the brain. The findings may have ... This is the "classic" means of communication between nerve cells, and lies at the base of most of current understanding of how ... Furthermore, gap junctions between excitatory cells were predicted to occur at an unexpected place: the axons of the cells (the ... what nerve cells have them, where on the cells are they located, and how are they controlled (i.e. can the gap junctions be ...
more infohttps://scienceblog.com/13717/evidence-found-for-novel-brain-cell-communication/

Cell-cell communication in bacteria: united we stand.  - PubMed - NCBICell-cell communication in bacteria: united we stand. - PubMed - NCBI

Cell-cell communication in bacteria: united we stand.. von Bodman SB1, Willey JM, Diggle SP. ... In panel b, the thick contour line separates the noninduced cells from the induced cells. The three-dimensional domain is ... Images are of 4-day-old biofilms in flow cells. (A) P. aeruginosa PAO1; (B) S. maltophilia K279a; (C) mixed culture of P. ... At low cell density, in the absence of autoinducers, hapR expression is repressed, thereby permitting the expression of ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/18456806

Stem Cell Renewal and Cell-Cell Communication | SpringerLinkStem Cell Renewal and Cell-Cell Communication | SpringerLink

... two topics that are now inexorably linked as science strives to understand the stem cell niche and its function. Gathering a ... This volume examines cell-cell interactions and stem cell renewal, ... Cardiomyocytes Cell to cell communications Pluripotent stem cells Stem cell niche Stem cell self-renewal ... Practical and reliable, Stem Cell Renewal and Cell-Cell Communication: Methods and Protocols will aid researchers in using ...
more infohttps://link.springer.com/book/10.1007%2F978-1-4939-2590-2

cell communication Protocols and Video...'cell communication' Protocols and Video...

... cell communication include Single-cell Microinjection for Cell Communication Analysis, Mechanical Stimulation-induced ... Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells, Analyzing the Communication ... Using Fluorescence Activated Cell Sorting to Examine Cell-Type-Specific Gene Expression in Rat Brain Tissue, Inhibitory ... A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions, Cell Aggregation Assays to Evaluate the ...
more infohttps://www.jove.com/keyword/cell+communication

Study Finds Enzyme Disrupting Nerve Cell Communication In Alzheimers Disease - RedorbitStudy Finds Enzyme Disrupting Nerve Cell Communication In Alzheimer's Disease - Redorbit

This scenario disrupts communication between nerve cells, and thus memory and cognitive ability in Alzheimers disease," said ... Study Finds Enzyme Disrupting Nerve Cell Communication In Alzheimers Disease. by Sam Savage ... "the connections that mediate communication between nerve cells""is driven by a chemical modification to an enzyme called Cdk5. ... the part of a nerve cell that transmits electrochemical signals to other nerve cells. Loss of synapses is known to correlate ...
more infohttp://www.redorbit.com/news/health/2095984/study_finds_enzyme_disrupting_nerve_cell_communication_in_alzheimers_disease/

BIN1 deficit impairs brain cell communication, memory consolidation | EurekAlert! Science NewsBIN1 deficit impairs brain cell communication, memory consolidation | EurekAlert! Science News

... lack of neuronal protein BIN1 leads to a defect in the transmission of chemical messages that activate brain cell communication ... BIN1 deficit impairs brain cell communication, memory consolidation Preclinical study by a University of South Florida Health- ... BIN1 deficit impairs brain cell communication, memory consolidation. University of South Florida (USF Health) ... Among the Cell Reports study highlights:. *Loss of BIN1 expression in neurons leads to impaired spatial learning and memory. ...
more infohttps://www.eurekalert.org/pub_releases/2020-03/uosf-bdi031120.php

Berlins neuroscientists decode important mechanism of nerve cell communicationBerlin's neuroscientists decode important mechanism of nerve cell communication

Berlins neuroscientists decode important mechanism of nerve cell communication. 21.12.2011. By researching fruit flies, ... which enables the sensible communication between nerve cells.. There are more and more indications that genetic defects in the ... Cluster of Excellence »Excellence »NeuroCure »RBP-protein »degenerative Erkrankung »fruit fly »nerve cell »neurological disease ... When our brain is at work, for example when we are looking at a picture or planning a movement, its nerve cells communicate ...
more infohttps://www.innovations-report.com/html/reports/life-sciences/berlin-s-neuroscientists-decode-important-mechanism-188033.html

New Cell-To-Cell Communication Process Could Revolutionize Bioengineering - SlashdotNew Cell-To-Cell Communication Process Could Revolutionize Bioengineering - Slashdot

The internet has revolutionized global communications and now researchers at Stanford University are looking to provide a ... New Cell-To-Cell Communication Process Could Revolutionize Bioengineering 49 Posted by samzenpus on Monday October 01, 2012 @12 ... New Cell-To-Cell Communication Process Could Revolutionize Bioengineering. Archived Discussion. Load All Comments ... Submission: Bi-Fi: New Cell-to-Cell Communication Process Could Revolutionize Bioengineering. ...
more infohttps://science.slashdot.org/story/12/10/01/1622207/new-cell-to-cell-communication-process-could-revolutionize-bioengineering

regulation of cell communication Gene Ontology Term (GO:0010646)regulation of cell communication Gene Ontology Term (GO:0010646)

The Gene Ontology (GO) project is a collaborative effort to address the need for consistent descriptions of gene products across databases. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated gene data at MGI are provided in Term Detail reports.
more infohttp://www.informatics.jax.org/vocab/gene_ontology/GO:0010646

Cell To Cell CommunicationCell To Cell Communication

... some of the molecules on the plasma membrane of one cell can be recognized by rec... ... When cells are very close to one another, ... Cell To Cell Communication. Print Reference this Disclaimer: ... www.ukessays.com/essays/biology/cell-to-cell-communication-biology-essay.php?vref=1 ,title=Cell To Cell Communication , ... November 2013). Cell To Cell Communication. Retrieved from https://www.ukessays.com/essays/biology/cell-to-cell-communication- ...
more infohttps://www.ukessays.com/essays/biology/cell-to-cell-communication-biology-essay.php

Cell Communication & Adhesion - WikipediaCell Communication & Adhesion - Wikipedia

Intercelluar communication Intercellular junctions Receptor-based cell recognition & signaling Cell Communication & Adhesion is ... Cell Communication & Adhesion homepage of Cell Communication & Adhesion. ... FRACP are the regional editors of Cell Communication & Adhesion. Cell Communication & Adhesion publishes 6 issues per year in ... Cell Communication & Adhesion is an academic journal that publishes review articles on intercellular communication, ...
more infohttps://en.wikipedia.org/wiki/Cell_Communication_&_Adhesion

Cell communication (biology) - WikipediaCell communication (biology) - Wikipedia

Much of cell communication happens when ligands bind to the receptors of the cell membrane and control the actions of the cell ... lack the cell communication that characterizes normal cells. "Cellular communication through membrane junctions: Special ... However, it is also through cell signaling that tumors and cancer can also develop. Stem cells and tumor-causing cells, however ... and direct communication, which means signals pass inside the cell itself. The junctions of these cells is incredibly important ...
more infohttps://en.wikipedia.org/wiki/Cell_communication_(biology)

Signal Transduction: cell to cell communication (thing) by jandradt - Everything2.comSignal Transduction: cell to cell communication (thing) by jandradt - Everything2.com

Cells communicate to coordinate what they do. They might be a group of cells al... ... Signal transduction is a way that cells talk to one another. ... Signal Transduction: cell to cell communication (thing). See ... Either way, the receiving cell gets a signal molecule from the sending cell.. Cell membranes are made of lipid molecules. Cells ... They might be a group of cells all specialized to do something specific, mating cells, or cells all about to divide. Just like ...
more infohttps://everything2.com/user/jandradt/writeups/Signal+Transduction%253A+cell+to+cell+communication

Journal of Cell Communication and Signaling - incl. option to publish open accessJournal of Cell Communication and Signaling - incl. option to publish open access

The Journal of Cell Communication and Signaling provides a forum for fundamental and translational research. In particular, it ... Addresses all aspects of cell-cell, cell-matrix communication, and intracellular signaling ... Life Sciences - Cell Biology , Journal of Cell Communication and Signaling - incl. option to publish open access ... Journal of Cell Communication and Signaling. Editor-in-Chief: Bernard Perbal. ISSN: 1873-9601 (print version). ISSN: 1873-961X ...
more infohttps://www.springer.com/life+sciences/cell+biology/journal/12079

Cilia on Algae Shed Light on Human Cell Communication | MedgadgetCilia on Algae Shed Light on Human Cell Communication | Medgadget

Basic science research from the investigators at UT Southwestern Medical Center might explain how human cells communicate. In ... Cilia on Algae Shed Light on Human Cell Communication. May 8th, 2006 Medgadget Editors News ... 3D Liquid-Cell Electron Microscopy Imaging Now Possible. Medtronics Tiny New InterStim Micro Neurostimulator Submitted to FDA ... The team focused on fertilization of the alga, a process that requires a cilium to bind to a molecule on a cilium from a cell ...
more infohttps://www.medgadget.com/2006/05/cilia_on_algae.html
  • The discovery, reported today (July 17) in the British scientific journal Nature, while fundamental in nature, is important because it adds an essential strand of information to scientists' understanding of how cells relay molecular messages, a process that, if disrupted, can result in cancer and defects in embryonic development. (eurekalert.org)
  • Models and methods of molecular communication are also reviewed, and research challenges that need to be addressed for further advancement of the molecular communication paradigm are discussed. (igi-global.com)
  • Molecular communication is an emerging technology that exploits biological materials or living matter to enable communication among biological nanomachines (or nanomachines in short) (Hiyama, 2005). (igi-global.com)
  • Molecular communication allows networking of nanomachines and potentially enables new applications in various domains including health (e.g., nanomedicine and tissue engineering), the environment (e.g., monitoring and quality control), ICT (Information Communication Technology)(e.g., implantable biological sensors and actuator networks), and military situations (e.g., biochemical sensing). (igi-global.com)
  • The starting point was two completely different cell environments - where the cells lie tightly packed next to each other so the cell membranes touch each other directly, and a fluid, where the cells float scattered around. (ku.dk)
  • This scenario disrupts communication between nerve cells, and thus memory and cognitive ability in Alzheimer's disease," said Dr. Lipton, professor and director of Sanford-Burnham's Del E. Webb Neuroscience, Aging and Stem Cell Research Center. (redorbit.com)
  • Our findings that BIN1 localizes right at the point of presynaptic communication and may be precisely regulating neurotransmitter vesicle release brings us much closer to understanding how BIN1 could exert its function as a common risk factor for Alzheimer's disease," Dr. Thinakaran said. (eurekalert.org)
  • A hexameric unit of these connexins in one cell (a connexon) couples with a corresponding connexon in a contiguous cell to join the cytoplasms. (nih.gov)
  • These connexins have been shown to suppress cancer cells, but this suppression is not the only thing that connexins facilitates. (wikipedia.org)
  • The idea that increasing cell communication, or more specifically, connexins, to suppress tumors has been a long, ongoing debate that is supported by the fact that so many types of cancer, including liver cancer, lack the cell communication that characterizes normal cells. (wikipedia.org)
  • At low cell density, in the absence of autoinducers, hapR expression is repressed, thereby permitting the expression of virulence factors and biofilm formation. (nih.gov)
  • It was found that this unique cell-to-cell signal controlled the expression of lasB , which encodes for the major virulence factor, LasB elastase. (pnas.org)
  • To explain the complex carcinogenic process by which a single normal cell in human beings can be converted to an invasive and metastatic cancer cell, a number of experimental findings, epidemiological observations and their associated hypothesis/theories have been integrated in this review. (nih.gov)
  • Our findings explain how minute changes in the lipid composition of our neurons can have a dramatic effect on the way these cells communicate with each other in the brain,' he says. (medicalsearch.com.au)
  • By revealing the terminus of the pathway by which cells send and receive messages, the find promises a rational basis for the future treatment of some diseases and, more immediately, gives science a new grasp of a process that triggers decisive events in cells. (eurekalert.org)
  • Under normal conditions, calcium does not flow freely into and out of cells until a demand for it - such as a muscle contraction or nerve function -- triggers cells to take up the free floating element from their surroundings. (medindia.net)
  • Gathering a number of representative protocols, this detailed collection promises to provide readers with approaches for studying these complimentary aspects of stem cells. (springer.com)
  • Practical and reliable, Stem Cell Renewal and Cell-Cell Communication: Methods and Protocols will aid researchers in using these methods to advance their own studies. (springer.com)
  • When our brain is at work, for example when we are looking at a picture or planning a movement, its nerve cells communicate with each other. (innovations-report.com)
  • Cells communicate to coordinate what they do. (everything2.com)
  • Basic science research from the investigators at UT Southwestern Medical Center might explain how human cells communicate. (medgadget.com)
  • This volume examines cell-cell interactions and stem cell renewal, two topics that are now inexorably linked as science strives to understand the stem cell niche and its function. (springer.com)
  • Many of the important interactions between cells in early development occur by means of direct contact between cell surfaces. (ukessays.com)
  • These interactions can arrange 'lattice' and the communication often happens through wave propagation. (ku.dk)
  • Abstract The influence of heart failure on the process of cell communication was investigated in cell pairs isolated from the ventricle of cardiomyopathic hamsters (11 months old) and the results compared with age-matched normal hamsters. (ahajournals.org)
  • To this end, a research team led by Stuart A. Lipton, M.D., Ph.D. at Sanford-Burnham Medical Research Institute (Sanford-Burnham) found that beta-amyloid-induced destruction of synapses""the connections that mediate communication between nerve cells""is driven by a chemical modification to an enzyme called Cdk5. (redorbit.com)
  • The model was used to investigate the effect of the spatial arrangement of autoinducer-producing cells on the accumulation of local autoinducer. (nih.gov)
  • On the other hand, the cancer cells of solid tissues appear to have either dysfunctional homologous or heterologous GJIC. (nih.gov)
  • The finding was stunning to us because calcium is one of the most important messengers in cells," says Desiderio, "and both it and TFII-I are in every cell. (medindia.net)
  • A critical step in communication between cells that promotes such things as bone formation, limb growth, and the development of other critical tissues, has been found by a team of researchers from the University of Wisconsin-Madison. (eurekalert.org)
  • This serves to synchronize either the metabolic or electrotonic functions of cells within a tissue. (nih.gov)
  • The universality for all these variants of tissue P systems is then proved by using two cells (three cells in the case of unidirectional communication) and rules of a minimal size. (springer.com)
  • Bernardini F, Gheorghe M (2004) Cell communication in tissue P systems and cell division in population P systems. (springer.com)
  • Cells from fatty tissue which are tightly packed. (ku.dk)
  • Therefore, among the many differences between a cancer cell and its normal parental cell, the carcinogenic process involves the transition from a normal, GJIC-competent cell to one that is defective in GJIC. (nih.gov)
  • Such receptor transmits information from the extracellular environment to the inside of the cell by changing shape or aggregating when a specific ligand binds to it. (ukessays.com)
  • Comparing a random (a) with a clustered (b) arrangement of the same number of cells, the threshold concentration for induction is reached only within and near the clusters. (nih.gov)
  • The researchers realized that when they depleted the cells of TFII-I, the cell responded by installing more calcium channels in their surfaces that allow calcium and only calcium to enter the cell. (medindia.net)
  • That is why we wanted to study cell communication and make a theoretical model, that clearly took the spatial position of different cells into consideration", explains Mogens Høgh Jensen, professor with the research group Biocomplexity at the Niels Bohr Institute at the University of Copenhagen. (ku.dk)
  • At high cell density and in the presence of autoinducers, LuxO is inactive, permitting HapR production. (nih.gov)