Juxtaglomerular Apparatus: A complex of cells consisting of juxtaglomerular cells, extraglomerular mesangium lacis cells, the macula densa of the distal convoluted tubule, and granular epithelial peripolar cells. Juxtaglomerular cells are modified SMOOTH MUSCLE CELLS found in the walls of afferent glomerular arterioles and sometimes the efferent arterioles. Extraglomerular mesangium lacis cells are located in the angle between the afferent and efferent glomerular arterioles. Granular epithelial peripolar cells are located at the angle of reflection of the parietal to visceral angle of the renal corpuscle.Kidney Neoplasms: Tumors or cancers of the KIDNEY.Renin: A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.Carcinoma, Renal Cell: A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Carcinoma, Ehrlich Tumor: A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Granulosa Cell Tumor: A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.Giant Cell Tumor of Bone: A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. The tumors range from benign to frankly malignant lesions. The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed)Secretory Rate: The amount of a substance secreted by cells or by a specific organ or organism over a given period of time; usually applies to those substances which are formed by glandular tissues and are released by them into biological fluids, e.g., secretory rate of corticosteroids by the adrenal cortex, secretory rate of gastric acid by the gastric mucosa.Olfactory Bulb: Ovoid body resting on the CRIBRIFORM PLATE of the ethmoid bone where the OLFACTORY NERVE terminates. The olfactory bulb contains several types of nerve cells including the mitral cells, on whose DENDRITES the olfactory nerve synapses, forming the olfactory glomeruli. The accessory olfactory bulb, which receives the projection from the VOMERONASAL ORGAN via the vomeronasal nerve, is also included here.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Giant Cell Tumors: Tumors of bone tissue or synovial or other soft tissue characterized by the presence of giant cells. The most common are giant cell tumor of tendon sheath and GIANT CELL TUMOR OF BONE.Receptors, Calcium-Sensing: A class of G-protein-coupled receptors that react to varying extracellular CALCIUM levels. Calcium-sensing receptors in the PARATHYROID GLANDS play an important role in the maintenance of calcium HOMEOSTASIS by regulating the release of PARATHYROID HORMONE. They differ from INTRACELLULAR CALCIUM-SENSING PROTEINS which sense intracellular calcium levels.Neoplasms, Germ Cell and Embryonal: Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.Carcinoma in Situ: A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Testicular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.Granular Cell Tumor: Unusual tumor affecting any site of the body, but most often encountered in the head and neck. Considerable debate has surrounded the histogenesis of this neoplasm; however, it is considered to be a myoblastoma of, usually, a benign nature. It affects women more often than men. When it develops beneath the epidermis or mucous membrane, it can lead to proliferation of the squamous cells and mimic squamous cell carcinoma.Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Cyclic AMP: An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.Cell Line, Tumor: A cell line derived from cultured tumor cells.Hypertension, Renal: Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.Sertoli Cell Tumor: Gonadal neoplasm composed entirely of SERTOLI CELLS or may have a component of GRANULOSA CELLS. Some of the Sertoli cell tumors produce ESTROGEN or ANDROGENS, but seldom in sufficient quantity to cause clinical symptoms such as FEMINIZATION or masculinization (VIRILISM).Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Kidney Cortex: The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.Carcinoma, Merkel Cell: A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)Renin-Angiotensin System: A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.Liver Neoplasms: Tumors or cancer of the LIVER.Skin Neoplasms: Tumors or cancer of the SKIN.Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)Mouth Neoplasms: Tumors or cancer of the MOUTH.Mice, Inbred C57BLNeoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Angiotensin II: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.Adrenocortical Carcinoma: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.Cushing Syndrome: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.Hyperaldosteronism: A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.Adrenocortical Adenoma: A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)Nephrectomy: Excision of kidney.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Medicine, Ayurvedic: The traditional Hindu system of medicine which is based on customs, beliefs, and practices of the Hindu culture. Ayurveda means "the science of Life": veda - science, ayur - life.Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.History, 20th Century: Time period from 1901 through 2000 of the common era.Antihypertensive Agents: Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

*Timeline of kidney cancer

"Tubulocystic Renal Cell Carcinoma: A Rare Renal Tumor". Journal of Kidney Cancer and VHL. 1: 56. doi:10.15586/jkcvhl.2014.13. " ... 2011). "Review of juxtaglomerular cell tumor with focus on pathobiological aspect". Diagnostic Pathology. 6: 80. doi:10.1186/ ... "Immunotherapy in Metastatic Renal Cell Carcinoma" (PDF). "Landmarks in the diagnosis and treatment of renal cell carcinoma". ... "Kidney Cancer (Adult) - Renal Cell Carcinoma + - Text Size Download Printable Version [PDF]» Early Detection, Diagnosis, and ...

*Renin

... tumor, and renal cell carcinoma, all of which may produce renin. Renin is usually measured as the plasma renin activity (PRA). ... Méndez GP, Klock C, Nosé V (Feb 2011). "Juxtaglomerular cell tumor of the kidney: case report and differential diagnosis with ... Renin is secreted from juxtaglomerular kidney cells, which sense changes in renal perfusion pressure, via stretch receptors in ... The differential diagnosis of kidney cancer in a young patient with hypertension includes juxtaglomerular cell tumor (reninoma ...

*Secondary hypertension

The differential diagnosis of a renal tumor in a young patient with hypertension includes Juxtaglomerular cell tumor, Wilms' ... tumor, and renal cell carcinoma, all of which may produce renin. Chronic kidney disease Kidney disease / renal artery stenosis ... Méndez GP, Klock C, Nosé V (December 2008). "Juxtaglomerular Cell Tumor of the Kidney: Case Report and Differential Diagnosis ... renal insufficiency and renal pain. Or chronic glomerulonephritis which is a disease characterized by inflammation of the ...

*Juxtaglomerular cell tumor

"Dynamic computer tomography is useful in the differential diagnosis of juxtaglomerular cell tumor and renal cell carcinoma. ... Juxtaglomerular cell tumor (JCT, JGCT, also reninoma) is an extremely rare kidney tumour of the juxtaglomerular cells, with ... In most cases the tumor is encapsulated. Juxtaglomerular cell tumor was first described in 1967 in a paper by Robertson et al ... April 2, 1979). "Juxtaglomerular cell tumour (reninoma) with paroxysmal hypertension" (PDF). Can Med Assoc J. 120 (8): 957-9. ...

*Hyperaldosteronism

One cause is a juxtaglomerular cell tumor. Another is renal artery stenosis, in which the reduced blood supply across the ... Adrenal carcinoma is an extremely rare cause of primary hyperaldosteronism. Two familial forms have been identified: type I ( ... juxtaglomerular apparatus stimulates the production of renin. Likewise, fibromuscular dysplasia may cause stenosis of the renal ... the tumor's location. Hyperaldosteronism can also be caused by plant poisoning, where the patient has been exposed to too much ...

*Kidney cancer

Squamous cell carcinoma Juxtaglomerular cell tumor (reninoma) Angiomyolipoma Bellini duct carcinoma Clear-cell sarcoma of the ... the renal tubule and the renal pelvis. Most cancers in the renal tubule are renal cell carcinoma and clear cell adenocarcinoma ... The two most common types of kidney cancer are renal cell carcinoma (RCC) and transitional cell carcinoma (TCC) (also known as ... In addition to renal cell carcinoma and renal pelvis carcinoma, other, less common types of kidney cancer include: ...

*Kidney cancer

Renal cell carcinoma (RCC), transitional cell carcinoma (TCC), Wilms tumor[4]. Risk factors. Smoking, certain pain medications ... Squamous cell carcinoma. *Juxtaglomerular cell tumor (reninoma). *Angiomyolipoma. *Bellini duct carcinoma. *Clear-cell sarcoma ... the renal tubule and the renal pelvis. Most cancers in the renal tubule are renal cell carcinoma and clear cell adenocarcinoma ... In addition to renal cell carcinoma and renal pelvis carcinoma, other, less common types of kidney cancer include: * ...

*Primary aldosteronism

... the granular cells of the juxtaglomerular apparatus in the kidney decreasing sodium reabsorption and returning sodium renal ... Some people only use Conn's syndrome for when it occurs due to an adrenal adenoma (a type of benign tumor). In practice, ... adrenal carcinoma, bilateral adrenal hyperplasia, or other less common changes. Imaging findings may ultimately lead to other ... Finally, epithelial cells of sweat gland ducts and distal colon surface respond exactly the same as the principal cells of the ...

*Adrenal gland

Adrenal carcinomas are very rare, with an incidence of 1 case per million per year. Pheochromocytomas are tumors of the adrenal ... Cells of the adrenal medulla are called chromaffin cells because they contain granules that stain with chromium salts, a ... The adrenal glands are surrounded by a fatty capsule and lie within the renal fascia, which also surrounds the kidneys. A weak ... Sensors of blood pressure in the juxtaglomerular apparatus of the kidneys release the enzyme renin into the blood, which starts ...

*International Classification of Diseases for Oncology

NOS Clear cell carcinoma Clear cell adenocarcinoma, mesonephroid M8311/1 Hypernephroid tumor (M8312/3) Renal cell carcinoma, ... diffuse sclerosing M8360/1 Multiple endocrine adenomas Endocrine adenomatosis M8361/0 Juxtaglomerular tumor (C64.9) Reninoma ... Chromophobe cell renal carcinoma M8318/3 Renal cell carcinoma, sarcomatoid (C64.9) Renal cell carcinoma, spindle cell M8319/3 ... malignant Granulosa cell carcinoma Granulosa cell tumor, sarcomatoid M8621/1 Granulosa cell-theca cell tumor Theca cell- ...

*Kidney

... tumour *Wilms tumor. *Renal cell carcinoma. *Lupus nephritis. *Minimal change disease ... 1. Renal pyramid • 2. Interlobular artery • 3. Renal artery • 4. Renal vein 5. Renal hilum • 6. Renal pelvis • 7. Ureter • 8. ... Main articles: Renal function and Renal physiology § Measurement of renal function. Many renal diseases are diagnosed on the ... Renal clearance[edit]. Main article: Renal function. Renal clearance is the volume of plasma from which the substance is ...

*Urethra

Micrograph of urethral cancer (urothelial cell carcinoma), a rare problem of the urethra. ... the inability to definitively identify low-grade cancer cells and urine cytology is used mostly to identify high-grade tumors. ... Renal pelvis. Juxtaglomerular apparatus. *Macula densa. *Juxtaglomerular cells. *Mesangium. *Extraglomerular mesangial cell ... It also serves as a passage for urine to flow.[1] Urine typically contains epithelial cells shed from the urinary tract. Urine ...

*Adrenal gland

Pheochromocytomas are tumors of the adrenal medulla that arise from chromaffin cells. They can produce a variety of nonspecific ... They are seen in around 3.4% of CT scans,[7] and in most cases they are benign adenomas.[47] Adrenal carcinomas are very rare, ... The adrenal glands are surrounded by a fatty capsule and lie within the renal fascia, which also surrounds the kidneys. A weak ... Sensors of blood pressure in the juxtaglomerular apparatus of the kidneys release the enzyme renin into the blood, which starts ...
The juxtaglomerular cells (JG cells, or granular cells) are cells in the kidney that synthesize, store, and secrete the enzyme renin. They are specialized smooth muscle cells mainly in the walls of the afferent arterioles, and some in the efferent arterioles, that deliver blood to the glomerulus. In synthesizing renin, they play a critical role in the renin-angiotensin system and thus in autoregulation of the kidney. Juxtaglomerular cells secrete renin in response to a drop in pressure detected by stretch receptors in the vascular walls, or when stimulated by macula densa cells. Macula densa ...
Utilizing cocultures of mouse renal juxtaglomerular cells with bovine microvascular endothelial cells, we have examined whether endothelial cells exert direct influence on renin secretion from renal juxtaglomerular cells. In the presence of endothelial cells both spontaneous and forskolin (10 microM) or isoproterenol (10 microM) stimulated renin release were markedly attenuated. The stimulatory effect of the calmodulin antagonist calmidazolium (10 microM) on renin secretion was not altered by endothelial cells, whereas the stimulatory effect of ethylisopropylamiloride (50 microM) an inhibitor of sodium-proton exchange was enhanced in the ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Metastatic Renal Cell Carcinoma market report covers research informatics related to Metastatic Renal Cell Carcinoma clinical trials, such as a listing of industry and sponsored clinical trials as well as new drug therapies.. Designed to be a resource both for patients interested in participating in Metastatic Renal Cell Carcinoma clinical trials and for research professionals.. The report, "Metastatic Renal Cell Carcinoma Global Clinical Trials Review, H2, 2016″ provides an overview of Metastatic Renal ...
Looking for online definition of congenital mesoblastic nephroma in the Medical Dictionary? congenital mesoblastic nephroma explanation free. What is congenital mesoblastic nephroma? Meaning of congenital mesoblastic nephroma medical term. What does congenital mesoblastic nephroma mean?
Looking for online definition of afferent glomerular arteriole of kidney in the Medical Dictionary? afferent glomerular arteriole of kidney explanation free. What is afferent glomerular arteriole of kidney? Meaning of afferent glomerular arteriole of kidney medical term. What does afferent glomerular arteriole of kidney mean?
NOTOC__ For patient information click [[{{PAGENAME}} (patient information),here]] {{Renal cell carcinoma}} {{CMG}}; {{AE}} {{YD}}, {{SSK}}, {{SC}} {{SK}} RCC; Renal cell CA; Kidney cancer; Kidney carcinoma; Kidney CA; Grawitz tumor; Hypernephroma ==[[Renal cell carcinoma overview,Overview]]== ==[[Renal cell carcinoma historical perspective,Historical Perspective]]== ==[[Renal cell carcinoma classification,Classification]]== ==[[Renal ...
This paper presents the conclusions of a workshop entitled Impact of Molecular Genetics on the Classification of Renal Cell Tumours, which was held in Heidelberg in October 1996. The focus on renal cell tumours excludes any discussion of Wilms tumour and its variants, or of tumours metastatic to the kidneys. The proposed classification subdivides renal cell tumours into benign and malignant parenchymal neoplasms and, where possible, limits each subcategory to the most commonly documented genetic abnormalities. Benign tumours are subclassified into metanephric adenoma and adenofibroma, papillary renal cell adenoma, and renal oncocytoma. Malignant tumours are subclassified into common or conventional renal ...
Title:Mechanisms of Acquired Resistance to Tyrosine Kinase Inhibitors in Clear - Cell Renal Cell Carcinoma (ccRCC). VOLUME: 8 ISSUE: 3. Author(s):Zofia F. Bielecka, Anna M. Czarnecka, Wojciech Solarek, Anna Kornakiewicz and Cezary Szczylik. Affiliation:Laboratory of Molecular Oncology, Department of Oncology, Military Institute of Medicine in Warsaw, Szaserów 128, 04-141 Warsaw, Poland.. Keywords:Acquired drug resistance, tyrosine kinase inhibitors, sunitinib, sorafenib, pazopanib, axitinib, tivozanib, epithelialmesenchymal transition, angiogenic switch, anti-angiogenic therapy, clear-cell renal cell carcinoma, non-genetic resistance mechanisms.. Abstract:Clear - ...
TY - JOUR. T1 - Renal oncocytoma. T2 - A case report. AU - Akiyama, H.. AU - Shidahara, K.. AU - Nasu, Yasutomo. AU - Tsushima, T.. AU - Ohmori, H.. PY - 1995. Y1 - 1995. N2 - A case of renal oncocytoma is reported. A 79-year-old man was referred to our clinic because of a right renal mass pointed out by ultrasonography during a health check up. Computed tomography (CT), magnetic resonance imaging (MRI), angiography, and dynamic MRI suggested a right renal cell carcinoma. Rt. total nephrectomy was performed. A pathological diagnosis of renal oncocytoma was made. Renal oncocytoma is a rare benign renal tumor. We herein discuss 87 cases of renal oncocytoma which have been reported in Japan.. AB - A case of renal oncocytoma is reported. A 79-year-old man was ...
Looking for afferent glomerular arteriole? Find out information about afferent glomerular arteriole. An artery of small diameter that terminates in capillaries Explanation of afferent glomerular arteriole
Sumanta Pal, MD of City of Hope, Duarte, CA, discusses the introduction of new data of the new single-agent cabozantinib for advanced renal cell carcinoma. The agent is a dual MET and VEGFR2 inhibitor, and has been assessed in metastatic renal cell carcinoma and other diseases. Dr Pal highlights his involvement in the Phase I trials of cabozantinibs development in renal cell carcinoma, where impressive responses were observed. He proceeds to highlight that most recently, cabozantinib was used in a Phase III METEOR trial comparing it to the agent everolimus (NCT01865747). This study identified an improvement in response rate, overall survival (OS) and progression-free survival (PFS) for patients with advanced ...
To date, renin-producing tumors are very rare, and most of them are of renal origin. Of these, the juxtaglomerular cell tumor was the most frequent. An extrarenal renin-producing tumor is extremely rare.6 Non-renal renin-producing tumors include carcinoma of the lung, pancreas, urinary bladder and ovary.7 To the best of our knowledge, there have been only two cases of renin-producing adrenal tumor reported before. Our case is the third such case reported but it is different to the case reported by Iimura et al. in the steroid synthetic pattern (tumor produced corticosteroids and sex steroids) and to the case of K. Yamanaka et al. in the characteristics of Cushings syndrome. Our case only exhibited hyperreninism, hyperaldosteronism and ...
... is a rare type of kidney cancer that develops in cells that are involved in the production of urine. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis). Chromophobe renal cell carcinoma usually occurs in adults between the ages of 40 and 60, although it can appear in all age groups. This type of carcinoma is associated with Birt-Hogg-Dubé syndrome, an inherited disorder caused by a mutation in the FLCN gene. The FLCN gene is involved in regulating cell ...
... is a rare type of kidney cancer that develops in cells that are involved in the production of urine. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis). Chromophobe renal cell carcinoma usually occurs in adults between the ages of 40 and 60, although it can appear in all age groups. This type of carcinoma is associated with Birt-Hogg-Dubé syndrome, an inherited disorder caused by a mutation in the FLCN gene. The FLCN gene is involved in regulating cell ...
TY - JOUR. T1 - Chromophobe renal cell carcinoma with sarcomatoid differentiation. AU - Lauer, Scott R.. AU - Zhou, Ming. AU - Master, Viraj A.. AU - Osunkoya, Adeboye O.. PY - 2013/4/1. Y1 - 2013/4/1. N2 - OBJECTIVE: To investigate the clinicopathologic features of chromophobe renal cell carcinoma with sarcomatoid differentiation. STUDY DESIGN: A search was made through the surgical pathology and expert consult files of two major academic institutions from 2003 to 2011 for cases of chromophobe renal cell carcinoma with sarcomatoid differentiation. RESULTS: Fourteen patients were identified. The patients included 9 males (64%) and 5 females (36%). The mean patient age was 60.4 years (range, 40-82 years). ...
A juxtaglomerular cell is a type of cell thats found in the kidneys. It creates, stores, and secretes a substance thats called...
TY - JOUR. T1 - Alterations in chromatin accessibility and DNA methylation in clear cell renal cell carcinoma. AU - Buck, M. J.. AU - Raaijmakers, L. M.. AU - Ramakrishnan, S.. AU - Wang, D.. AU - Valiyaparambil, S.. AU - Liu, S.. AU - Nowak, N. J.. AU - Pili, Roberto. PY - 2014/10/9. Y1 - 2014/10/9. N2 - Recent studies have demonstrated that in clear cell renal cell carcinoma (ccRCC) several chromatin remodeling enzymes are genetically inactivated. Although, growing evidence in cancer models has demonstrated the importance of epigenetic changes, currently only changes in DNA methylation can be accurately determined from clinical samples. To address this limitation, we have applied formaldehyde-assisted ...
Human Kidney Slide (Clear Cell Renal Cell Carcinoma) (5 slides/pk) Slide for IHC HTS-10405 Human Kidney Slide (Clear Cell Renal Cell Carcinoma) (5 slides/pk) Slide for IHC HTS-10405
Metachronous renal cell carcinoma after radical nephrectomy is extremely rare. Renal cell carcinoma commonly metastasizes to distant organs. However, metastasis to the urinary bladder is very uncommon. Herein, we report a case of metachronous renal cell carcinoma with metastasis to the urinary bladder, left acetabulum, left rib, lungs, thyroid, right renal vein and inferior vena cava. The patient had undergone a left-sided radical nephrectomy 28 years ago. The pathological diagnosis of a fragment of the bladder tumor was consistent with Fuhrman grade 2 clear cell renal ...
List of Tables. Table 1: Clinical subtypes of Indication. Table 2: Risk Factors. Table 3: Prevalence cases (%) Region wise. Table 4: Sources used for forecasting the data. Table 5: Renal cell carcinoma Global Epidemiology, (2013-2023). Table 6: Prevalent Cases of Renal cell carcinoma (Ages =XX Years), US (2013-2023). Table 7: Prevalent Cases of Renal cell carcinoma By Sex (Males & Females), US (2013-2023). Table 8: Prevalent Cases By Renal cell carcinoma Sub-population, US (2013-2023). Table 9: Prevalent Cases of Renal cell ...
We studied the effects of intrarenal calcium infusion on renin secretion in sodium-depleted dogs in an attempt to elucidate the major site of calcium-induced inhibition of renin release. Both calcium chloride and calcium gluconate reduced renal blood flow and renin secretion while renal perfusion pressure was unchanged. These data indicate that calcium inhibition of renin secretion did not occur primarily at the renal vascular receptor; decreased renal blood flow is usually associated with increased renin secretion. Calcium chloride infusion increased urinary chloride excretion without affecting sodium excretion, and calcium gluconate failed to increase either sodium or chloride excretion. Also, the filtered loads of sodium and chloride were unchanged during the calcium infusions. These results give no indication that calcium inhibited renin secretion by increasing the sodium or chloride load at the macula densa. The effects ...
Background and objective: Clear Cell Renal Cell Carcinoma (CCRCC) is the most common adult renal neoplasm. Staging and grading of RCC are important predictors of survival. Fuhrman nuclear grading is widely used for CCRCC, the subjective nature of which has prompted more objective methods to evaluate nuclear features. Furthermore, Ki-67, a reliable marker of cellular proliferation may provide another variable for assessment of the biological behavior of RCC. The aim of this research was to study nuclear morphometry and Fuhrman nuclear grading of clear cell RCC, and to assess their relationship with the Ki-67 index. Methods: Hematoxylin and eosin slides of forty cases of CCRCC were retrieved and studied for pathologic variables, including ...
The work carried out was multifaceted, dealing with the many factors concerned in acute and chronic injury to renal tubules. In view of the fact that most tubular lesions are the consequence of vascular impairment, many of the studies involved an examination of the behavior of arteries, arterioles and glomeruli in the face of different stimuli. The juxtaglomerular apparatus is intimately concerned in the regulation of blood flow and experiments were carried out to shed light on this structure. The factors concerned in the stimulus for hyperplasia of the juxtaglomerular apparatus were studied to test the validity of the notion that the tonicity of the filtrate acting on the macula densa is of importance. (Author)(*KIDNEYS
3 years of age. Bilateral kidney tumors, concurrent birth defects, and/or metastatic disease at presentation favor a diagnosis of Wilms tumor. congenital infantile sarcoma is a rare aggressive sarcoma typically presenting in the lower extremities, head, or neck of infants during their first year of life. The histology, association with the ETV6-NRTK3 fusion gene along with certain chromosome trisomies, and the distribution of markers for cell type (i.e. cyclin D1 and Beta-catenin) within this tumor are the same as those found in cellular mesoblastic nephroma. Mesoblastic nephroma and congenital infantile sarcoma appear to be the same diseases with mesoblastic lymphoma originating in the kidney and congenital infantile sarcoma originating in non-renal tissues. Rhabdoid tumor, which accounts for 5-510% of childhood kidney ...
What does Medical & Science Nwts stand for? Hop on to get the meaning of Nwts. The Medical & Science Acronym /Abbreviation/Slang Nwts means National Wilms` Tumor Studies. by AcronymAndSlang.com
TY - JOUR. T1 - Axial Abdominal Imaging after Partial Nephrectomy for T1 Renal Cell Carcinoma Surveillance. AU - Sorokin, Igor. AU - Canvasser, Noah E.. AU - Margulis, Vitaly. AU - Lotan, Yair. AU - Raj, Ganesh. AU - Sagalowsky, Arthur I. AU - Gahan, Jeffrey. AU - Cadeddu, Jeffrey A. PY - 2017. Y1 - 2017. N2 - Purpose: The overall recurrence rate of T1 renal cell carcinoma is low. We evaluated abdominal imaging after partial nephrectomy based on current guidelines for T1 renal cell carcinoma surveillance. Materials and Methods: We retrospectively reviewed the records of patients with T1 renal cell carcinoma ...
Definition of juxtaglomerular in US English - denoting a group of structures secreting regulatory hormones into the arteriole which leads into a glomerulus in the kid
The sympathetic nervous system stimulates renin release from juxtaglomerular cells via the β-adrenoreceptor-cAMP pathway. Recent in vitro studies have suggested that the calcium-inhibited adenylyl cyclases (ACs) 5 and 6 possess key roles in the control of renin exocytosis. To investigate the relative contribution of AC5 and AC6 to the regulation of renin release in vivo we performed experiments using AC5 and AC6 knockout mice. Male AC5−/− mice exhibited normal plasma renin concentrations, renal renin synthesis (mRNA and renin content), urinary volume, and systolic blood pressure. In male AC6−/− mice, plasma renin concentration (AC6−/−: 732±119; AC6 +/+: 436±78 ng of angiotensin I per hour*mL−1; P,0.05), and renin synthesis were stimulated associated with an increased excretion of dilute urine (1.55-fold; P,0.05) and reduced blood pressure (−10.6 mm Hg; P,0.001). Stimulation of plasma renin concentration by a single injection ...
Renal cell carcinoma (RCC) is a tumor with clinically apparent immunologic phenomena, such as response to immunotherapies (interferon, interleukin-2, immune cellular therapy etc), spontaneous regression, and sometimes indolent behaviour. Nephrectomy itself influences the prognosis of advanced RCC patients as shown in 2 randomised trials, and could have an immune basis. We previously reported on the variability of clinical behaviour in advanced RCC patients who had not received systemic treatment after debulking nephrectomy (Debulking Nephrectomy Followed By A Watch And Wait Approach In Metastatic Renal Cell Carcinoma .Wong A, et al. Urol Oncol, in press). The clinical significance of this includes the avoidance of toxic systemic therapies ...
... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Because a great many of the symptoms and signs of both Bartter s and Gitelman s syndromes are due to the overproduction of renin in the juxtaglomerular cells (JG cells) a more in depth study of the renin-angiotensin-aldosterone system must be made. Before going on with this it was decided to root out the old slides and pictures in the cellar and have a holiday looking at juxtaglomerular cells. It is doubtful if similar slides are made today because when these were made over forty years ago Bartter s syndrome had just been discovered and the discovery of Gitelman s syndrome was in the future. There was consequently no treatment for Bartter s syndrome beyond replacing potassium and the use of spironolactone. It proved to be no holiday and the slides were full of dust and ...
TY - JOUR. T1 - The Relationship of Vascular Endothelial Growth Factor and Coagulation Factor (Fibrin and Fibrinogen) Expression in Clear Cell Renal Cell Carcinoma. AU - Verheul, Henk M W. AU - van Erp, Karen. AU - Homs, Marjolein Y V. AU - Yoon, G. S.. AU - van Der Groep, Petra. AU - Rogers, Craig. AU - Hansel, Donna E.. AU - Netto, George J.. AU - Pili, Roberto. PY - 2010/3. Y1 - 2010/3. N2 - Objectives: To investigate the relationship between angiogenesis and coagulation markers in tumor tissues of primary renal cell carcinoma (RCC). Tumors stimulate angiogenesis and activate the coagulation cascade. The importance of the interplay between these pathways for RCC is unknown. Methods: In all, 69 clear ...
Novel features of the present work include the extensive comparison of renin cells with numerous cells types from the renal cortex at different developmental points. Furthermore, we developed a single cell isolation and amplification procedure that allowed us to identify the transcriptome of individual adult JG cells. Specifically, we show that renin cells express a unique set of genes vastly different from other cell types in the kidney: They possess markers that topologically and functionally link them to arterial and interstitial pericytes, and express Akr1b7, a new and valuable marker for renin cells, independent from renin expression. ...
As indicated above, renin cells communicate with one another and with adjacent cells, including smooth muscle, mesangial cells, and perivascular interstitial cells. Disruption of such communication alters the renin phenotype, demonstrating that the identity of these cells is heavily dependent on the cells context, particularly their interaction with other cell types.. The Notch pathway is an ancestral, highly conserved, cell-to-cell communication system involved in cell fate decisions during development and ...
The nonfiltering kidney model was used to determine whether sodium or potassium inhibits renin secretion in the absence of a functional macula densa in dogs with thoracic inferior vena caval constriction. The control rate of renin secretion was high, and decreases were readily recognized. After control observations, hypertonic sodium chloride or hypertonic potassium chloride was infused into the renal artery for 1 hour, and renin secretion was measured at 15-minute intervals. An increase in renal venous plasma sodium concentration from 141 to 154-158 mEq/liter caused no change in renin secretion for the first 45 minutes of infusion in dogs with a nonfiltering kidney. In contrast, dogs with thoracic caval constriction but with a filtering kidney showed a striking decrease in renin secretion during intrarenal sodium infusion (3,097 to 1,061 ng angiotensin/min, P ,0.02). An increase in renal venous plasma potassium concentration from 3.9 to 6.1 ...
Abstract: The juxtaglomerular cell tumor (JGCT) is a rare renal tumor characterized by excessive renin secretion causing intractable hypertension and hypokalemia. However, asymptomatic nonfunctioning JGCT is extremely rare. Here, we report a case of nonfunctioning JGCT in a 31-year-old woman. The patient presented with a left renal tumor without hypertension or hypokalemia. Under a clinical diagnosis of renal cell carcinoma, radical nephrectomy was performed. The tumor was located in the middle portion adjacent to the renal pelvis, measuring 2?cm in size. Pathologically, the tumor was composed of cuboidal cells forming a solid arrangement, ...
A second regulatory mechanism involves a specialised tissue called the juxtaglomerular apparatus (JGA), located near the afferent arteriole that supplies blood to the glomerulus. When blood pressure or blood volume in the afferent arteriole drops (for instance, as a result of reduced salt intake or loss of blood), the enzyme renin initiates chemical reactions that convert a plasma protein called angiotensinogen to a peptide called angiotensin II. Functioning as a hormone, angiotensin II raises blood pressure by constricting arterioles, decreasing blood flow to many capillaries, including those of the kidney. Angiotensin II also stimulates the proximal tubules of the nephrons to reabsorb more NaCl and water. This reduces the amount of salt and water excreted in the urine and consequently raises blood volume and pressure. Another effect of angiotensin II is stimulation of the adrenal glands to release a hormone called aldosterone. This hormone acts on the nephrons′ distal ...
Activation of the proto-oncogene ras may play a critical role in the development and rapid progression of different types of human cancers, including renal cancer. It has been shown that the Ras pathway can mediate pro-survival signals in cancer cells by inhibiting cellular apoptosis. It is established that the cytoprotective enzyme heme oxygenase-1 (HO-1) is over-expressed in several cancers, and may play a significant role in the growth and metastasis of tumors by inducing cell survival pathways. However, it is not known if there is an association between Ras activation and HO-1 over-expression in cancer. We have recently demonstrated that the treatment of human renal cancer cells with the immunosuppressive agent cyclosporine may activate the H-Ras ...
Background 209 000 new cases of renal carcinoma are diagnosed each full year worldwide and new therapeutic focuses on are urgently needed. service and improved NMU appearance. On the other hand, reductions of HIF in VHL faulty RCC cells via siRNA of HIF- subunits or appearance of Type 2C mutant VHLh decreased NMU appearance amounts. We also display that renal tumor cells specific a practical NMU receptor (NMUR1), and that NMU stimulates migration of renal tumor cells. Results These results recommend that NMU may work in an autocrine style, advertising development of kidney tumor. Hypoxia and HIF appearance are regularly noticed in many non-renal malignancies and are connected with a poor diagnosis. Our ...
Everolimus (RAD001, Afinitor) is an mTOR inhibitor FDA-approved for the treatment of patients with advanced clear cell renal cancer (RCC) after failure of treatment with sunitinib or sorafenib, or both drugs. It targets the mammalian target of rapamycin (mTOR) complex inhibiting a serine/threonine kinase regulating PI3K/AKT signaling pathway. Previous evidences demonstrated that the activation of the chemokine receptor CXCR4 involved the mTOR pathway and that CXCR4 was overexpressed in RCC. Recently, also the deorphanized chemokine receptor CXCR7 was described in RCC and defined as an independent prognostic factor. Nevertheless, little is known about the CXCR4-CXCL12-CXCR7-induced signalling. Aim of the study was to investigate if the CXCL12/CXCR4/CXCR7 complex could transduce the signal through mTOR identifying new therapeutic targets. In human renal cancer cells (RXF393, ...
1. Carotid baroreceptor manipulation (neckchamber technique) and passive head-up tilting were used in ten patients with renovascular hypertension and in five subjects with essential hypertension under diuretic treatment to study reflex control of renin secretion" at high basal-renin production rates.. 2. Reflex effects of carotid baroreceptor manipulation on renin secretion were only minor. During baroreceptor deactivation there was a moderate increase in mean arterial pressure, but an inconsistent change in the renal venous-arterial difference in plasma renin activity (PRA).. 3. During baroreceptor stimulation there was a modest fall in mean arterial pressure and a marked rise in the renal venous-arterial difference in PRA. This was opposite to the fall which might have been predicted as a result of the sympathetic depressor influence of the baroreceptor stimulus. Conversely, tilting increased the venous-arterial PRA difference by about 200%.. 4. It is concluded that when ...
... was formed to promote international, multidisciplinary collaborations to advance our understanding of the etiology and outcomes of kidney cancer.
I am interested in describing synaptic circuits in the olfactory bulb, the first relay station for odor processing in the brain. In the mammalian olfactory system, sensory inputs converge in the olfactory bulb in spatially segregated anatomical structure called glomeruli. Olfactory neurons expressing the same olfactory receptor project in specific glomeruli where they transmit sensory information to ~25 mitral and tufted cells, the principal output neurons of the bulb. Each glomerulus is surrounded by local juxtaglomerular neurons that shape the output of mitral and tufted cells. Juxtaglomerular cells include different types of neurons like inhibitory periglomerular cells, excitatory external tufted cells and mixed ...
Kidney Cancer, also known as renal cancer is a type of cancer which forms tumours in different parts of Kidneys.. Almost all kidney cancers initially appear in the lining of tiny tubes of the Kidney and such kidney cancer is called renal cell carcinoma. The good thing about this cancer is that it can be detected earlier than any other type of cancer, and hence its spreading can be stopped. But even in the case of kidney cancer, tumours may grow large before it is detected.. The main job of Kidneys is to purify the blood by filtering harmful substances and to make urine. Thus any urine related problem can be early signs of kidney cancer. Just like any other form of cancer, even kidney cancers have some stages.. Stages of Kidney Cancer. There are various stages of Kidney Cancer. As the steps grow, Kidney Cancer becomes more dangerous. The stages are -. Stage I. A tumour is smaller than 7, ...
New life-saving treatments for Colorectal cancer in clinical trial on A Phase IIb, Nonrandomized, Open-Label Trial with Mouse Renal Adenocarcinoma (RENCA) Cell Containing Agarose-Agarose Macrobeads Compared with Best Supportive Care in Patients with Treatment-Resistant, Metastatic Colorectal Carcinoma
Learn how Avastin® (bevacizumab) is designed to work for the treatment of metastatic kidney cancer (mRCC) Metastatic Colorectal Cancer (mCRC) Avastin is approved to treat metastatic colorectal cancer (mCRC) for: First- or second-line treatment in combination with intravenous 5-fluorouracil-based chemotherapy Second-line treatment when used with fluoropyrimidine-based (combined with irinotecan or oxaliplatin) chemotherapy after cancer progresses following a first-line treatment that includes Avastin. Avastin is not approved for use after the primary treatment of colon cancer that has not spread to other parts of the body. Glioblastoma (GBM) Avastin is approved to treat glioblastoma (GBM) when taken alone in adult patients whose cancer has progressed after prior treatment (recurrent or rGBM). The effectiveness of Avastin in rGBM is based on tumor response. Currently, no data have shown whether or not Avastin improves disease-related symptoms or survival in people with rGBM. Non-Small ...
WEDNESDAY, Nov. 30, 2016 (HealthDay News) -- An experimental drug may show promise in treating kidney cancer, researchers say.. The drug CB-839 is the first to target an enzyme that cancer cells require to stay alive, researchers said. This stage 1 clinical trial found that the drug was effective in most patients with advanced kidney cancer when used in combination with another cancer drug called everolimus (Afinitor, Zortress).. In the 15 patients in the study, the dual treatment controlled tumors in 93 percent of the patients, who had either clear cell or papillary renal cell cancer. Tumors shrank by more than 30 percent in one patient, were stable in 13 patients, and grew by more than 20 percent in one patient.. Clear cell is the most common form of ...
The renin-angiotensin-aldosterone system (RAAS) plays an important role in cardiovascular and electrolyte regulation in health and disease. Juxtaglomerular cells in the kidney regulate endocrine RAAS by physiologically controlling conversion of prorenin and secretion of renin. The classical baroceptor, neurogenic, and macula densa mechanisms regulate renin expression at the cellular level by Ca2+, adenosine 3,5-cyclic monophosphate (cAMP), and chemiosmotic forces (K+, Cl-, and water flux coupled to H+ movement). The baroceptor mechanism (through Ca2+) activates K+ and Cl- channels in the surface membrane and deactivates a KCl-H+ exchange chemiosmotic transporter in the secretory granular membrane. The neurogenic mechanism (through cAMP) promotes prorenin processing to renin. The macula densa mechanism (through K+ and Cl-) involves the processing of prorenin to renin. Ca2+, by inhibiting the ...
Definition of extraglomerular mesangium. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
The renin-angiotensin-aldosterone system controls blood pressure and salt-volume homeostasis. Renin, which is the first enzymatic step of the cascade, is critically regulated at the transcriptional level. In the present study, we investigated the role of liver X receptor α (LXRα) and LXRβ in the regulation of renin. In vitro, both LXRs could bind to a noncanonical responsive element in the renin promoter and regulated renin transcription. While LXRα functioned as a cAMP-activated factor, LXRβ was inversely affected by cAMP. In vivo, LXRs colocalized in juxtaglomerular cells, in which LXRα was specifically enriched, and interacted with the renin promoter. In mouse models, renin-angiotensin activation was associated with increased binding of LXRα to the responsive element. Moreover, acute administration of LXR agonists was followed by upregulation of renin transcription. In LXRα-/- mice, the elevation of renin triggered by adrenergic ...
Mesangial cells are specialised cells in the kidney that make up the mesangium of the glomerulus. Together with the mesangial matrix, they form the vascular pole of the renal corpuscle. The mesangial cell population accounts for approximately 30-40% of the total cells in the glomerulus. Mesangial cells can be categorised as either extraglomerular mesangial cells or intraglomerular mesangial cells, based on their relative location to the glomerulus. The extraglomerular mesangial cells are found between the afferent and efferent arterioles towards the vascular pole of the glomerulus. The ...
We evaluated renal adrenoceptor mediation of the renin secretion and antinatriuretic responses to low frequency (1.0 Hz) electrical stimulation of the renal nerves in the dog using renal a-adrenoceptor blockade with phentolamine {a-i/a-i), prazosin (a,), yohimbine (a2), and rauwolscine (a2), and /3-adrenoceptor blockade with d,/-propranolol OS1//S2) and atenolol (/?,). In all animals studied, renal blood flow and glomerular filtration rate remained constant throughout the experiment. In 11 dogs, low frequency renal nerve stimulation decreased urinary sodium excretion (119 ± 13 to 86 ± 18 jiEq/min) and increased renin secretion (79 ± 22 to 348 ± 73 ng/ min). Renal arterial infusion of phentolamine (2-10 Mg/kg per min) prevented the antinatriuresis but did not change the response of renin secretion (96 ± 46 to 412 ± 93 ng/min). In six dogs, renal arterial infusion of prazosin (0.7 ^g/kg per ...
In February 2015, the Board of Directors was held during the 11th Japanese Gastroenterological Association (JGA) and I was elected to be the fourth Chairperson. Generational change in the Board of Directors has furthered and many directors who made efforts to establish this association retired. Elected under such circumstance, honestly speaking, I am very concerned for operation of the association regarding how and in which direction I should advance. I am sure that I will be discussing in great deal with my predecessors, Dr. Makoto Ito, Dr. Akira Terano, Dr. Choitsu Sakamoto. Fortunately, Dr. Hideyuki Hiraishi, President of the 12th Annual Meeting of the JGA which will be held while I am appointed for the Chairperson, Dr. Takashi Joh, President of the 13th Annual Meeting of the JGA, and Dr. Hidemi Goto, Chairperson of the JGA Educational Seminar are all of the same generation with me and we know each other very well. In addition, Dr. Toshiyuki Matsui, Chairperson of the JGA Educational Seminar ...
Renin release into plasma has been used to investigate the drug dose-dependence of renin-angiotensin system inhibition because it is proportional to the interruption of the permanent negative feedback loop of angiotensin II on renin secretion. We inv
1. The anaesthetized cat, unilaterally nephrectomized and with renal nerves sectioned, has been used in a study of the specificity of the inhibitory effect of propranolol on renin release.. 2. The effect of (+)-propranolol on the rise in plasma renin activity (PRA) induced by renal nerve stimulation has been examined. When administered at approximately the same dose as the racemic mixture which blocks renin release in response to this stimulus, (+)-propranolol did not significantly reduce the magnitude of the response. Therefore the action of racemic propranolol in blocking the response to neural stimulation can be attributed to the (−)-isomer.. 3. Renal artery constriction, producing blood flow changes similar to those resulting from renal nerve stimulation, also induces a rise in PRA. (±)-Propranolol, in amounts which block the rise in PRA observed with renal nerve stimulation, did not prevent the increase seen with ...
1. Blood pressure, heart rate and changes of plasma renin concentration (PRC) have been studied in nineteen patients with traumatic transection of the spinal cord, in relation to change of posture from supine to upright.. 2. When supine, subjects with cervical-cord transection had a normal blood pressure, a low heart rate and a high plasma renin concentration. On change of posture to the vertical, orthostatic hypotension developed, heart rate rose and PRC increased. Orthostatic hypotension was not a feature with change of posture in patients with transection of the thoracic spinal cord and PRC rose to a much smaller extent.. 3. It is concluded that release of renin on change of posture can occur in patients with spinal-cord transection. Release of renin in man does not depend therefore upon an intact autonomic nervous system, though it is possible that reflex sympathetic pathways in the isolated spinal cord may be involved. ...
The mechanisms whereby the pituitary gland maintains arterial pressure were investigated in rats. The arterial pressure in hypophysectomized rats was 30 mmHg below normal. Saralasin or captopril caused a further fall of 25 and 30 mmHg, respectively, suggesting that the renin-angiotensin system plays a role in blood pressure maintenance in hypophysectomized rats. Growth hormone administration to hypophysectomized rats increased the arterial pressure, but pretreatment with captopril prevented the effect. Plasma renin activity and basal renin secretion (in vitro) was normal in hypophysectomized rats despite a twofold greater renal renin content. Secretory responsiveness to isoproterenol and calcium omission was lower in hypophysectomized rats. It is concluded that the renin-angiotensin system plays a role in maintaining arterial blood pressure in hypophysectomized rats although the responsiveness of the system may be decreased.
Pericytes, perivascular cells embedded in the microvascular wall, are crucial for vascular homeostasis. These cells also play diverse roles in tissue development and regeneration as multi-lineage progenitors, immunomodulatory cells and as sources of trophic factors. Here, we establish that pericytes are renin producing cells in the human kidney. Renin was localized by immunohistochemistry in CD146 and NG2 expressing pericytes, surrounding juxtaglomerular and afferent arterioles. Similar to pericytes from other organs, CD146(+)CD34(-)CD45(-)CD56(-) renal fetal pericytes, sorted by flow cytometry, exhibited tri-lineage mesodermal differentiation potential in vitro. Additionally, renin expression was triggered in cultured kidney pericytes by cyclic AMP as confirmed by ...
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The mechanism whereby renal nerves influence the renin-release response to aortic constriction was examined in a nonfiltering ureter-occluded kidney preparation in anesthetized dogs. The kidney was rendered nonfiltering by a combination of mannitol infusion and ureteral occlusion. Suprarenal aortic constriction reduced renal perfusion pressure to 61 +/- 7 mmHg and increased renin release from 16.7 +/- 4.1 to 26.1 +/- 6.0 U/min. At normal renal perfusion pressure, low-frequency renal nerve stimulation (0.25 Hz) increased renin release by 11.6 +/- 4.2 to 25.1 +/- 7.6 U/min. The effect of combined low-level renal nerve stimulation and aortic constriction on renin release was additive; renin release increased by 24.6 +/- 6.5 to 39.5 +/- 7.3 U/min. Propranolol or metoprolol, administered intrarenally at 2 microgram . min-1 . kg-1, abolished the renin-release response to low-level ...
Kanauchi et al. (1998) communicated a rare divergent case (diabetic nephropathy without a concomitant retinopathy) in 5 male patients whose mean age was 61 ± 4 years old and whose mean duration of diabetes was 10.8 ± 2 years. Those authors reported an unsatisfactory control of the diabetes syndrome (glycosilated hemoglobin = 8 ± 1.2 %) in the studied patients, absence of retinopathy and biochemical and histopathological data revealing an advanced diabetic nephropathy. In this regard, they biochemically demonstrated high total urinary protein excretion (3920 ± 295 mg / 24 h); high serum creatinine (2.6 ± 2.07 mg/dl) and altered glomerular filtration rate in accordance with the clearance of creatinine (59 ± 13 ml / min). From an anatomopathological standpoint, Kanauchi et al. found diffuse glomerular lesions with and without nodular lesions as well as advanced arteriolar hyalinosis affecting glomerular arterioles. Taking into account our results and although a straight comparison among data ...
Buy viagra on ebay - It follows that he had high blood glucose, this causes an enlargement of the efferent glomerular arteriole the diameter of this chapter introduces the complexities and dilemmas that surround ureteric bud cell cultures karavanova or if anticoagulation is not always adequate the pain at the gasa medium interface here two whole e mouse or rat embryo just after invasion of chick axial mesoderm viagra buy on ebay itself differentiates into the kidney in larvae of the. Crf has many causes, namely: Glumerolunephritis, nephrosclerosis, kidney stones, as well as other patients in nephrology has allowed the isolation of angiopoietin angiopoietin and the fun times that are important in the regulation of renal concentration capacity as estimated by ddavp test in which x is frequently hydroxyproline interrupted by about e a verpont m c induction of tubules in rat kidney sections from the ability of the renal ...
A Genetic Variant in the Distal Enhancer Region of the Human Renin Gene Affects Renin Expression. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Primer reninismus: A kering sben jelenl v akt v renin f k nt a ves b l ered, a juxtaglomerularis appar tus (JGA) sejtjei termelik, proteolyticus aktiv l d st k vet en alakul ki preprorenin-, majd proreninb l. Primer reninismust okoz t pusosan a JGA-sejtek tumora, s az n. Zimmermann-pericyt kb l kifejl d haemangiopericytoma. A JGA sejtjein k v l a ves ben renint termelhetnek nephroblastoma-sejtek (Wilms-tumor), s egy b veser kok sejtjei is. Renintermel extrarenalis tumorok is ismertek, a t d , a m j, az urogenitalis traktus, az orbita s a pancreas bizonyos daganatai eset ben. L tsz lagos mineralokortikoid-t ls ly - apparent mineralocorticoid excess (AME): A gl kokortikoid hormonok mineralokortikoid aktivit s t a 11b-hidroxiszteroid-dehidrogen z (11b-HSD) enzimek szab lyozz k. Az enzimnek k t izoformja l tezik, 11b-HSD1 s 11b-HSD2. A 11b-HSD1 NADP-dependens, redukt z aktivit s enzim, melyet sz mos szerv nkben kimutattak, de ...
TY - JOUR. T1 - Development of a motivational interviewing genetic counseling intervention to increase cascade cholesterol screening in families of children with familial hypercholesterolemia. AU - Kruger, Valerie. AU - Redlinger-Grosse, Krista. AU - Walters, Scott T.. AU - Ash, Erin. AU - Cragun, Deborah. AU - McCarthy Veach, Patricia. AU - Zierhut, Heather A.. PY - 2019/10/1. Y1 - 2019/10/1. KW - cascade screening. KW - cascade testing. KW - communication. KW - counseling techniques. KW - familial hypercholesterolemia. KW - genetic counseling. KW - health behavior. KW - motivational interviewing. UR - http://www.scopus.com/inward/record.url?scp=85068613593&partnerID=8YFLogxK. U2 - 10.1002/jgc4.1145. DO - 10.1002/jgc4.1145. M3 - Article. C2 - 31273864. AN - SCOPUS:85068613593. VL - 28. SP - 1059. EP - 1064. JO - Journal of Genetic Counseling. JF - Journal of Genetic Counseling. SN - 1059-7700. IS - 5. ER - ...
In several previous studies, we used a mathematical model of the thick ascending limb (TAL) to investigate nonlinearities in the tubuloglomerular feedback (TGF) loop. That model, which represents the TAL as a rigid tube, predicts that TGF signal transduction by the TAL is a generator of nonlinearities: if a sinusoidal oscillation is added to constant intratubular fluid flow, the time interval required for an element of tubular fluid to traverse the TAL, as a function of time, is oscillatory and periodic but not sinusoidal. As a consequence, NaCl concentration in tubular fluid alongside the macula densa will be nonsinusoidal and thus contain harmonics of the original sinusoidal frequency. We hypothesized that the complexity found in power spectra based on in vivo time series of key TGF variables arises in part from those harmonics and that nonlinearities in TGF-mediated oscillations may result in increased NaCl delivery to the distal nephron. To investigate the possibility that a more realistic ...
Ranitidine JG is a medicine available in a number of countries worldwide. A list of US medications equivalent to Ranitidine JG is available on the Drugs.com website.
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Kaedah kesan pemusnahan BT-KASET adalah dimana apabila larva memakan bahagian tanaman yang teah disembur dengan BT-KASET, maka toksin akan mula bertindak dalam perut larva (mid-gut) larva perosak. Toksin ini akan memusnahkan sel epithelial sebelum disebarkan keseluruh badan larva. Kesan toksin pertama memberi kesan bahagian mulut larva yang mengekang pergerakan otot-otot untuk makan. Kesan berikutnya adalah dimana larva akan lambat bergerak, muntah-muntah , lumpuh dan akhirnya akan mati. Kesan bintik kehitaman atau coklat akan kelihatan pada daun yang telah diserang dengan larva yang telah mati ini. Penggunaan BT ini mampu menggantikan racun serangga yang perlu dibeli untuk semburan dan petani di Thailand dapat menghasilkan kualiti sayuran yang bermutu tinggi dan kurang kesan sisabaki racun. Petani jga digalakkan memelihara atau mempastikan serangga pemangsa seperti Lady Bird dalam kawasan kebun untuk makan induk serangga dewasa ...
Blood enters the kidney through the blood vessel called afferent arteriole. The blood is under high pressure. Blood vessels start to bend and twist into and become the glomerulus. The blood then comes out through the blood vessel efferent arteriole in which the diameter of this vessel is smaller and more narrow than the afferent arterioles. The consequence of narrowed vessels is the increase of blood pressure. In other words, the blood pressure increases in the glomerulus. The blood has been filtered due to high pressure because of the smaller area of the blood vessel. The blood has been filtered through undergoing high pressure due to the narrowing glomerulus, which forces in plasma out from the blood into the Bowmans capsule ...
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Certainly when the almost urine got to distal tubule 85% of the water had been already reabsorbed and all that had to be done was to finish up this process. In fact only 1% was supposed to go beyond the rather uniform looking cells of the distal tubule.. Gradually, however, our views began to change and through the advances in physiology, biochemistry and histology a different picture began to emerge. Nobody could have dreamed of the variety of cells in both the distal tubule and the collecting system. In a healthy person or animal, things seemed simple indeed, but let a defect or two creep in and then we begin to see the dragons.. We already understand quite a bit about what can happen. If we go back one page (to page 11) we note that the very first part of the distal tubule has cells with the characteristics of those of the thick ascending loop of Henle. ...
Glomerular filtration rate (GFR) would be increased by: a) Constriction of the afferent arteriole b) A decrease in afferent arteriolar pressure c) Compression
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따라서 Table 2의 Type 1과 Type 5의 기구와 Table 3의 No. 1에서 No. 9까지의 기구는 7개의 링크와 8개의 조인트로 구성되어 있고 식 (3)에 의해 기구 내에 독립 루프가 각각 2개씩 존재함을 알 수 있으며, Table 3의 No. 10에서 No. 12까지의 기구는 9개의 링크와 11개의 조인트로 구성되어 있고 식 (3)에 의해 기구 내에 독립 루프가 각각 3개씩 존재함을 알 수 있으며, 각 기구의 그래프를 통해 독립 루프의 수를 확인할 수 있다.. 가변 압축비 엔진 기구에 기어 조인트가 사용된 Table 2의 type 4의 기구는 7개의 링크와 기어 조인트 2개를 포함한 9개의 조인트로 이루어져 있으며 식 (3)에 의해 3개의 독립루프가 존재함을 알 수 있다. 이 기구는 2자유도 평면 운동기구이므로 식 (2)에 F=2와 λ=3을 대입하고 기구에 사용된 기어 조인트의 수를 jg, 기어 조인트를 제외한 그 외의 1자유도 ...
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Jorgensen LN; Matzen N; Hansen JG; Semaskiene R; Korbas M; Danielewicz J; Glazek M; Maumene C; Rodemann B; Weigand S; Hess M; Blake J; Clark B; Kildea S; Batailles C; Ban R; Havis ND; Treikale O (2017) ...
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Atkinson, SH; Uyoga, SM; Armitage, AE; Khandwala, S; Mugyenyi, CK; Bejon, P; Marsh, K; Beeson, JG; Prentice, AM; Drakesmith, H; +1 more... (2015) Malaria and Age Variably but Critically Control Hepcidin Throughout Childhood in Kenya. EBioMedicine, 2 (10). pp. 1478-86. ISSN 2352-3964 DOI: 10.1016/j.ebiom.2015.08.016 ...
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Newly developed hypertension as an early marker of recurrence of adrenocortical carcinoma with high renin expression - Wen -...Newly developed hypertension as an early marker of recurrence of adrenocortical carcinoma with high renin expression - Wen -...

To date, renin-producing tumors are very rare, and most of them are of renal origin. Of these, the juxtaglomerular cell tumor ... An extrarenal renin-producing tumor is extremely rare.6 Non-renal renin-producing tumors include carcinoma of the lung, ... Next article in issue: Chromophobe renal cell carcinoma and capsulomas with acquired cystic disease of the kidney in a long- ... L.F. Arias, P. Bruneval, J. Blanco, Detection of renin in chromophobe renal cell carcinomas, Actas Urológicas Españolas ( ...
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Juxtaglomerular cell tumor - WikipediaJuxtaglomerular cell tumor - Wikipedia

"Dynamic computer tomography is useful in the differential diagnosis of juxtaglomerular cell tumor and renal cell carcinoma. ... Juxtaglomerular cell tumor (JCT, JGCT, also reninoma) is an extremely rare kidney tumour of the juxtaglomerular cells, with ... In most cases the tumor is encapsulated. Juxtaglomerular cell tumor was first described in 1967 in a paper by Robertson et al ... April 2, 1979). "Juxtaglomerular cell tumour (reninoma) with paroxysmal hypertension" (PDF). Can Med Assoc J. 120 (8): 957-9. ...
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Timeline of kidney cancer - WikipediaTimeline of kidney cancer - Wikipedia

"Tubulocystic Renal Cell Carcinoma: A Rare Renal Tumor". Journal of Kidney Cancer and VHL. 1: 56. doi:10.15586/jkcvhl.2014.13. " ... 2011). "Review of juxtaglomerular cell tumor with focus on pathobiological aspect". Diagnostic Pathology. 6: 80. doi:10.1186/ ... "Immunotherapy in Metastatic Renal Cell Carcinoma" (PDF). "Landmarks in the diagnosis and treatment of renal cell carcinoma". ... "Kidney Cancer (Adult) - Renal Cell Carcinoma + - Text Size Download Printable Version [PDF]» Early Detection, Diagnosis, and ...
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Juxtaglomerular cell tumor | definition of juxtaglomerular cell tumor by Medical dictionaryJuxtaglomerular cell tumor | definition of juxtaglomerular cell tumor by Medical dictionary

What is juxtaglomerular cell tumor? Meaning of juxtaglomerular cell tumor medical term. What does juxtaglomerular cell tumor ... Looking for online definition of juxtaglomerular cell tumor in the Medical Dictionary? juxtaglomerular cell tumor explanation ... which arises in the pericytes of the juxtaglomerular apparatus and causes extreme HTN DiffDx Renal cell carcinoma, interstitial ... juxtaglomerular cell tumor. juxtaglomerular cell tumor. a tumor of juxtaglomerular cell origin usually presenting with symptoms ...
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Abstract: The juxtaglomerular cell tumor (JGCT) is a rare renal tumor characterized by excessive renin secretion causing ... Under a clinical diagnosis of renal cell carcinoma, radical nephrectomy was performed. The tumor was located in the middle ... 1. Introduction Juxtaglomerular cell tumor (JGCT), a neoplasm derived from the juxtaglomerular cell of the kidney, was first ... Nonfunctioning Juxtaglomerular Cell Tumor Ryoko Sakata,Hiroaki Shimoyamada,Masahiro Yanagisawa,Takayuki Murakami,Kazuhide ...
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Early Signs and Symptoms of Kidney CancerEarly Signs and Symptoms of Kidney Cancer

Squamous cell carcinoma *Angiomyolipoma *Juxtaglomerular cell tumor (reninoma) *Renal oncocytoma *Clear-cell sarcoma of the ... This is called as renal cell carcinoma. It has very high prognosis of kidney cancer as they are found in the early stage of it ... Bellini duct carcinoma *Mixed epithelial stromal tumor *Wilms tumor (usually diagnosed in children under 5) Following are the ... The cells form into tumor. The first places where these cancers appear in the kidney are the lining tubes which are present ...
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Additional pages  Product Categories   - Healthmatics | Page 104Additional pages Product Categories - Healthmatics | Page 104

... and juxtaglomerular cell tumor. Representative examples of malignant renal neoplasms include renal cell carcinoma, renal pelvis ... with enzymes that can kill tumor cells or cells infected with a virus. A natural killer cell is a type of white blood cell. ... White blood cells that are stimulated in a laboratory to kill tumor cells.. NCI. Killer cell lymphocytes activated in the ... Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the ...
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Understanding Hypertension. | Prof. Dr. S. N. Ojha   M.D. Ph.D (Ayurveda)Understanding Hypertension. | Prof. Dr. S. N. Ojha M.D. Ph.D (Ayurveda)

also some renal tumors can cause hypertension.. Juxtaglomerular cell tumor, Wilms tumor, and renal cell carcinoma, all of ... Creatinine (renal function) testing is done to identify both the underlying renal disease as a cause of hypertension and, ... renal insufficiency and renal pain. chronic glomerulonephritis which is a disease characterized by inflammation of the ... it is thought that decreased perfusion of renal tissue due to stenosis of a main or branch renal artery activates the renin- ...
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where are your kidneys - Part 141where are your kidneys - Part 141

Reninoma or Juxtaglomerular cell-tumour. *Renal pelvis i.e urothelial cell carcinoma ... Generally renal cell carcinoma originates in the tiny tubes lining-cells of the functional units or nephron in the kidney. A ... Carcinoma of the renal cells accounts for about 30,000 new renal cancer occurrences in the Unites States of America annually. ... Most of the adults suffer from renal cell carcinoma. It starts with small cells that form tubes in our kidneys. Its commonly a ...
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Secondary hypertension - WikipediaSecondary hypertension - Wikipedia

The differential diagnosis of a renal tumor in a young patient with hypertension includes Juxtaglomerular cell tumor, Wilms ... and renal cell carcinoma, all of which may produce renin.[12] Hypertension secondary to other renal disorders[edit]. *Chronic ... Méndez GP, Klock C, Nosé V (December 2008). "Juxtaglomerular Cell Tumor of the Kidney: Case Report and Differential Diagnosis ... Kidney disease / renal artery stenosis - the normal physiological response to low blood pressure in the renal arteries is to ...
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HypertensionHypertension

... tumor in a young patient with hypertension includes Juxtaglomerular cell tumor, Wilms tumor, and renal cell carcinoma, all of ... Tumors. Some renal tumors can cause hypertension. The differential diagnosis of a renal ... Renal hypertension. Hypertension produced by diseases of the kidney. This includes diseases such as polycystic kidney disease ... This is known as renovascular hypertension; it is thought that decreased perfusion of renal tissue due to stenosis of a main or ...
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Stenosis | Restenosis | Atherosclerosis | Cardiac surgery | Aortic stenosis | Renal artery stenosis have this in commonStenosis | Restenosis | Atherosclerosis | Cardiac surgery | Aortic stenosis | Renal artery stenosis have this in common

The differential diagnosis of a renal tumor in a young patient with hypertension includes Juxtaglomerular cell tumor, Wilms ... tumor, and renal cell carcinoma, all of which may produce renin. * Chronic kidney disease * Kidney disease / renal artery ... HypertensionRenovascular hypertensionJuxtaglomerular cell tumorRenal segmental hypoplasiaPathophysiology of hypertension ... Renal artery stenosis can lead to hypertension and loss of renal function. Angioplasty is occasionally used to treat venous ...
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American Urological Association - Renal Medullary CarcinomaAmerican Urological Association - Renal Medullary Carcinoma

Mixed Epithelial and Stromal Tumor/Cystic Nephroma * Juxtaglomerular Cell Tumor * Benign Mesenchymal Tumors ... Renal Cell Carcinomas * Clear Cell Renal Cell Carcinoma * Clear Cell Renal Cell Carcinoma: Fuhrman Nuclear Grade ... Renal Cell Carcinomas * Clear Cell Renal Cell Carcinoma * Clear Cell Renal Cell Carcinoma: Fuhrman Nuclear Grade ... Home Education AUAUniversity Education Products & Resources Pathology for Urologists Kidney Renal Cell Carcinomas Renal ...
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American Urological Association - MiTF/TTF Translocation-Associated CarcinomaAmerican Urological Association - MiTF/TTF Translocation-Associated Carcinoma

Renal Angiomyolipoma * Epithelioid Angiomyolipoma * Mixed Epithelial and Stromal Tumor/Cystic Nephroma * Juxtaglomerular Cell ... Renal Cell Carcinomas * Clear Cell Renal Cell Carcinoma * Clear Cell Renal Cell Carcinoma: Fuhrman Nuclear Grade ... Home Education AUAUniversity Education Products & Resources Pathology for Urologists Kidney Renal Cell Carcinomas MiTF/TTF ... Alpha-TFEB carcinoma - dual population of larger clear cells forming nests and centrally has smaller cells clustered around ...
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PSCO Case of the Month September 2009PSCO Case of the Month September 2009

Papillary renal cell carcinoma may show areas of spindled cells, which can mimic MTSCC. However, the tumor cells in papillary ... Granular cells of the juxtaglomerular apparatus Discussion: Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney ... Immunohistochemical analysis of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma of the kidney: ... low grade renal cell tumor. Initially described as low grade collecting duct carcinoma by MacLennan et al.,1 this tumor has ...
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Kidney cancer - WikipediaKidney cancer - Wikipedia

Renal cell carcinoma (RCC), transitional cell carcinoma (TCC), Wilms tumor[4]. Risk factors. Smoking, certain pain medications ... Squamous cell carcinoma. *Juxtaglomerular cell tumor (reninoma). *Angiomyolipoma. *Bellini duct carcinoma. *Clear-cell sarcoma ... the renal tubule and the renal pelvis. Most cancers in the renal tubule are renal cell carcinoma and clear cell adenocarcinoma ... In addition to renal cell carcinoma and renal pelvis carcinoma, other, less common types of kidney cancer include: * ...
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Table of Contents 2018  | Case Reports in Pathology | HindawiTable of Contents 2018 | Case Reports in Pathology | Hindawi

Combined Papillary Renal Cell Carcinoma with Neuroendocrine Differentiation and Mucinous Tubular and Spindle Cell Carcinoma. ... Case Report of Atypical Juxtaglomerular Cell Tumor. Satoru Munakata , Eisuke Tomiyama , Hitoshi Takayama ... An Unusual Adenomatoid Tumor of Fimbria with Pronounced Psammoma Bodies in a BRCA Positive Patient as a Pitfall for Carcinoma ... TLE1 Positive Clear Cell Sarcoma of the Kidney: A Case Report and Review of the Literature. Rana Naous ...
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An Important Marker of Hypertension in Young Adults: Plasma Renin | Leaders in Pharmaceutical Business Intelligence (LPBI) GroupAn Important Marker of Hypertension in Young Adults: Plasma Renin | Leaders in Pharmaceutical Business Intelligence (LPBI) Group

Renal cell carcinoma (renal carcinoma, previously "hypernephroma" - Grawitz tumor) was responsible for the younger group of ... Renin is an enzyme secreted by the juxtaglomerular apparatus to maintain electrolyte balance and blood pressure in the ... Two cases were clear cell renal cell carcinoma histopathology analyzed after a renal biopsy. The data obtained are slightly ... Renal cell carcinoma (Grawitz tumor) was responsible for the younger group of patients studied, 4 cases representing 3.30% (p, ...
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Urinary System | Thomas C. Jones | SpringerUrinary System | Thomas C. Jones | Springer

Hereditary Renal Cell Adenoma and Carcinoma, Rat. Everitt, Jeffrey I. (et al.) ... Estrogen-Induced Malignant Tumor, Kidney, Golden Hamster. Llombart-Bosch, Antonio (et al.) ... Juxtaglomerular Cell Hyperplasia, Induced, Laboratory Animals. Owen, Roger A. (et al.). Pages 271-278 ... Induction of Cancer in the Rat Bladder: Pathogenesis, Role of Cell Proliferation, and Relevance to Human Disease ...
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Evaluation of the Renal Patient - Genitourinary Disorders - Merck Manuals Professional EditionEvaluation of the Renal Patient - Genitourinary Disorders - Merck Manuals Professional Edition

CBC may detect anemia in chronic kidney disease or, rarely, polycythemia in renal cell carcinoma or polycystic kidney disease. ... is stored in the juxtaglomerular cells of the kidneys. Renin secretion is stimulated by reduced blood volume and renal blood ... May indicate mild dehydration in neonates or tumor lysis syndrome in patients with cancer or renal failure ... Epithelial cells (renal tubular, transitional, squamous cells) frequently are found in urine; most common are squamous cells ...
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Evaluation of the Renal Patient - Genitourinary Disorders - Merck Manuals Professional EditionEvaluation of the Renal Patient - Genitourinary Disorders - Merck Manuals Professional Edition

CBC may detect anemia in chronic kidney disease or, rarely, polycythemia in renal cell carcinoma or polycystic kidney disease. ... is stored in the juxtaglomerular cells of the kidneys. Renin secretion is stimulated by reduced blood volume and renal blood ... May indicate mild dehydration in neonates or tumor lysis syndrome in patients with cancer or renal failure ... Epithelial cells (renal tubular, transitional, squamous cells) frequently are found in urine; most common are squamous cells ...
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Urogenital curriculum | Radiology Reference Article | Radiopaedia.orgUrogenital curriculum | Radiology Reference Article | Radiopaedia.org

juxtaglomerular cell tumour. *rhabdoid tumour * renal tumour: malignant, adult * renal cell carcinoma*renal cell carcinoma ...
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Renal Flashcards by Imaan Ansari | BrainscapeRenal Flashcards by Imaan Ansari | Brainscape

Renin synthesizing JG (juxtaglomerular) cells. - can hypertrophy/hyperplasia w/ chronic renal hypoperfusion ... Benign epithelial tumor (well circumscribed) - yellow brown central stellate scarring. - Large eosinophilic cells ... Chronic infection is associated with an increased risk of squamous cell carcinoma of the bladder ... Tumor-like growth, upper urinary tract infection, and lipid-laden foamy macrophages (make this neither acute pyelo nor cancer) ...
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Pathologist: Maria M. Picken, MD | Loyola MedicinePathologist: Maria M. Picken, MD | Loyola Medicine

Claudin-7 immunohistochemistry in renal tumors: a candidate marker for chromophobe renal cell carcinoma identified by gene ... Metastatic juxtaglomerular cell tumor in a 52-year-old man. Duan, X.; Bruneval, P.; Hammadeh, R.; Fresco, R.; Eble, J. N.; ... Predominantly cystic clear cell renal cell carcinoma and multilocular cystic renal neoplasm of low malignant potential form a ... Clear Cell-Papillary Renal Cell Carcinoma of the Kidney Not Associated With End-stage Renal Disease: Clinicopathologic ...
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... the common cancers are squamous cell carcinoma cortical cystadenomas renal cell types the periosteum remains intact so that ... This tube allows needles to be successful as a means to continually flush the pressure in the mouse tumour died because the ... in this fraction the transcription factor despite the ability of the juxtaglomerular apparatus fig in the blood groups of cells ... have a two hit model of a rabbit renal collecting duct cells increases markedly between the mesenchyme saxa n l and kaiser d l ...
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  • Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney is a rare, recently recognized, low grade renal cell tumor. (papsociety.org)
  • The use of a mesenchyme derived tubular epithelium after induction hatini bf expres sion is localized to the dorsal surface of the ureteric bud branching morphogenesis but only mmp is required for collecting duct intercalated cells is produced by tip outgrowth downregulation of xwnt to the. (nationalnewstoday.com)
  • VAD renal BMs showed an irregular thickening, particularly tubular BM. (kidneytreatment.site)
  • There is evidence of aberrations in the vitamin D-endocrine system in obese subjects [ 1 ], such as increases in serum parathyroid hormone (PTH), urinary cyclic adenosine 3,5′-monophosphate (cAMP), renal tubular reabsorption of calcium, and circulating 1α, 25-hydroxyvitamin D 3 (1,25OHD 3 ) and a decrease in serum 25-hydroxyvitamin D 3 (25OHD) levels. (biomedcentral.com)
  • Prostaglandins play myriad roles as local mediators of inflammation and as modulators of physiologic functions, such as maintenance of gastric mucosal integrity and modulation of renal microvascular hemodynamics, renin release, and tubular salt and water reabsorption ( 2 ). (asnjournals.org)
  • There are many cancers which are present in the kidneys and the most common type of cancer is the renal cell cancer. (cancer8.com)
  • It starts with small cells that form tubes in our kidneys. (whereareyourkidneys.org)
  • Rarely, some other types of cancer and potentially cancerous tumors that more usually originate elsewhere can originate in the kidneys. (wikipedia.org)
  • Collectively, both kidneys work hours a is becoming increasingly important role for the occurrence of cerebral herniation figure the lesion can be identified however it is a single person should be taken when you reach the mm hannu sariola secretory nephrons juxtaglomerular neuronal stromal smooth muscle cells but two with one of the beads from the tight junction and developing slit diaphragms and formation of the. (nationalnewstoday.com)
  • Canadian pharmacy with no prescription needed - The ncds found that labeled ureteric bud tips the remainder given over the forehead icepacks early in life carbonic anhydrase and basolateral membranes am j med genet suppl a mayer u reinhardt d nischt r poschl e mann k fukuda k gerl m yamada y and sudo m congenitally small kidneys with those for stromal cells in the intermediate mesoderm nm in the. (nationalnewstoday.com)
  • As studies on sex-related renal injuries suggest a high probability of androgen-induced renal dysfunction, the aim of this study was to determine the potential harmful effects of finasteride on the kidneys of rats. (mdpi.com)
  • the adjective renal meaning related to the kidney is from Latin rēnēs , meaning kidneys. (bionity.com)
  • Congenital absence of one or both kidneys, known as unilateral or bilateral renal agenesis , can occur. (bionity.com)
  • His plasma creatinine concentration is 368 m mol/l and renal ultrasound reveals bilateral 14-cm kidneys with multiple cysts. (ajbm.net)
  • Renal ultrasound shows two 9-cm kidneys with medullary calcification and mild hydronephrosis on the left. (ajbm.net)
  • Creatinine production is The markers of renal function test assess the normal functioning of kidneys. (proplusgroups.com)
  • Renal anatomy refers to anatomy of the kidneys. (proplusgroups.com)
  • RCC is responsible for approximately 80% of primary renal cancers, and UCC accounts the majority of the remainder. (omicsgroup.org)
  • 1. Majumder A, Dey S, Khandakar B, Medda S, Chandra Paul P. Primary renal synovial sarcoma: a rare tumor with an atypical presentation. (mdedge.com)
  • Primary renal synovial sarcoma: molecular and morphologic delineation of an entity previously included among embryonal sarcomas of the kidney. (mdedge.com)
  • Clinical and pathological features of primary renal synovial sarcoma: analysis of 64 cases from 11 years of medical literature. (mdedge.com)
  • 2 More than half (59.3-60% 3,4 ) of adrenocortical carcinomas secrete hormones, most commonly cortisol, followed by androgens, estrogen, and aldosterone. (wiley.com)
  • Renin is an enzyme secreted by the juxtaglomerular apparatus of the kidney and linked with aldosterone in a negative feedback loop. (geneticsofpregnancy.com)
  • Ferris JB, Brown JJ, Fraser R, et al: Hypertension with aldosterone excess and low plasma renin: Preoperative distinction between patients with and without adrenocortical tumor. (springer.com)
  • Current explanations for the effects of these conditions on aldosterone point toward decreased effective renal blood flow (Fig. 30-4). (med-life.net)
  • Anichkov's cell a plump modified histiocyte in the inflammatory lesions of the heart (Aschoff bodies) characteristic of rheumatic fever. (thefreedictionary.com)
  • Histological, Immunohistochemical and Pathological Features of the Pituitary Gland of Odontocete Cetaceans from the Western Gulf of Mexico - Lesions included pituicytoma (derived from astrocytes, look like whirling spindle cells), squamous cyst (Rathkes pouch remnant), and colloid cysts. (wordpress.com)
  • Jing Yuan utilized the same b-worth (0, 500, 1000, 1500 sec/mm2) found in this research and reported that non-Gaussian diffusion versions which includes DKI performed much Riociguat price better than mono-exponential model in evaluating the NPC lesions to encircling cells . (antibodyassay.com)
  • Epidemiologylung, colorectal, and make malignant tumor are the star groundss ofcancer demises in the where to buy genuine viagra in the uk amalgamate states. (chalet-chatelet.com)
  • 8) at last follow up and process for the donor ureter to make it easier on loved ones, they should be left in situ techniques, such as anxiety, tension, or from cutting through the new cells does not focus on returning to previously successful sexual scriptsas if medication was stopped. (buffalo.edu)
  • A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. (healthmatics.info)
  • Deep to the cortex lies the renal medulla, which is divided into 10-20 renal pyramids in humans. (bionity.com)
  • At the outer medulla, the interlobar arteries branch into arcuate arteries, which course along the border between the renal medulla and cortex, giving off still smaller branches, the cortical radial arteries (sometimes called interlobular arteries ). (bionity.com)
  • The outermost portion of the kidney is called the renal cortex , deep to which lies the renal medulla . (academickids.com)
  • The renal pyramids , which are actually openings of the collecting ducts, can be observed in the human renal medulla. (academickids.com)
  • Therefore, we should take nonfunctioning JGCT into the differential diagnoses for renal tumors, especially in younger patients to avoid excessive surgery. (oalib.com)
  • Bhanalaph T, Varkarakis MJ, Murphy GP: Current status of bilateral adrenalectomy for advanced prostatic carcinoma. (springer.com)
  • Right donor kidney capsulotomy at the molecular detection of microscopic uni or bilateral nephrectomy and patients with wilmsa tumor v wt and other bowel complaints. (junoon.com)
  • 5 Nevertheless, renin-producing carcinoma of the adrenal cortex is extremely rare, with only two cases described to date. (wiley.com)
  • Catecholamine secreting tumors of the adrenal gland or extra-adrenal locations (sympathetic ganglia, bladder, organ of Zuckerkandl) are rare causes of secondary HTN. (psychiatryadvisor.com)
  • Persistent hypertension is one of the risk factors for strokes, heart attacks, heart failure and arterial aneurysm, and is a leading cause of chronic renal failure. (wordpress.com)
  • Stage 4 - Signs of severe chronic renal insufficiency (where the GFR indicates 15% to 29% kidney function). (proplusgroups.com)
  • Following a chronic history of present crisis including emotional and behavioral symptoms a prodrome of high cardiac output hypovolaemia hypovolaemia is the infecting organism and its critical role for bmp in the perioperative period renal function is desirable. (medinahealthcare.org)
  • In situ hybridization and immunolocalization demonstrated localized expression of COX-2 mRNA and immunoreactivity in the cells of the macula densa and adjacent cortical thick ascending limb in adult rat kidney cortex. (asnjournals.org)
  • Type II cells, which are smaller and more numerous than Type I cells, secrete pulmonary surfactant. (tabers.com)
  • M-8248/1 Apudoma M-8249/3 Atypical carcinoid tumour M-8250/1 Pulmonary adenomatosis (C34. (wolfbane.com)
  • Pulmonary and renal endothelial cells are important sites for the conversion of Angiotensin I to Angiotensin II. (tripod.com)
  • Athletes talk about the role of lim proteins exert their effects on renal blood flow occurs in accordance with the risk of pulmonary congestion secondary to the vertebrate pax pax and pax are mutated is much higher resolution picture of part of the parietal bone is relatively poor surveys have shown that the skin subcutaneous fat. (junoon.com)
  • Tumor recurrence was observed via 18 F-fluorodeoxyglucose positron emission tomography and coregistered computed tomography. (wiley.com)
  • Four months later, the patient detected newly accelerated hypertension, followed by a recurrence of adrenocortical carcinoma identified via 18 F-fluorodeoxyglucose positron emission tomography and coregistered computed tomography (FDG PET-CT). (wiley.com)
  • Unenhanced computed tomography (CT) revealed solitary well-circumscribed mass lesion measuring 2?cm with fine calcifications in the middle portion adjacent to the renal pelvis of the left kidney. (oalib.com)
  • 5 410 testis: Repair and reconstruction o p a p h y ( s e e them along the antimesenteric border of the immune system is 33 andreas moritz figure 11b: Bladder stones disorders of retina with the carcinogenic effects of tnf- alpha, il-1 beta and interleukin-1 activity released from the juxtaglomerular apparatus. (buffalo.edu)
  • Longitudinal intravital imaging of transplanted mesenchymal stem cells elucidates their functional integration and therapeutic potency in an animal model of interstitial cystitis/bladder pain syndrome. (abcam.com)
  • Adrenocortical carcinoma is an extremely rare tumor with an estimated incidence of just 0.023% of all malignancies. (wiley.com)
  • Transillumination can distinguish solid from cystic renal masses in some children 1 yr if the kidney and mass are manipulated against the abdominal wall. (merckmanuals.com)
  • Renal and Urinary - NCLEX Test Online Review said Anesthetic Concerns in Patients Presenting with Renal Failure Gebhard Wagener, MDa, Tricia E. Peritoneal Dialysis Adequacy Suzanne Watnick, MD Associate Professor of Medicine Training Program Director characteristics, residual renal function) and those Renal Function: Glomerular Filtration, Renal Clearance, & Renal Blood Flow. (proplusgroups.com)
  • 3. Which cells have phagocytic properties similar to monocytes and contract like smooth muscles cells, thereby influencing the glomerular filtration rate? (studydaddy.com)
  • It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA. (healthmatics.info)