The study of the structure, behavior, growth, reproduction, and pathology of cells; and the function and chemistry of cellular components.
One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.
Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.
A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.
The field of biology which deals with the process of the growth and differentiation of an organism.
The fundamental, structural, and functional units or subunits of living organisms. They are composed of CYTOPLASM containing various ORGANELLES and a CELL MEMBRANE boundary.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
A field of biological research combining engineering in the formulation, design, and building (synthesis) of novel biological structures, functions, and systems.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Societies whose membership is limited to scientists.
Cellular processes, properties, and characteristics.
Time period from 2001 through 2100 of the common era.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Time period from 1901 through 2000 of the common era.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Cellular functions, mechanisms, and activities.
Methods used to study CELLS.
A field of medicine concerned with developing and using strategies aimed at repair or replacement of damaged, diseased, or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.
Nonparasitic free-living flatworms of the class Turbellaria. The most common genera are Dugesia, formerly Planaria, which lives in water, and Bipalium, which lives on land. Geoplana occurs in South America and California.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Cells with high proliferative and self renewal capacities derived from adults.
The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.
The study of the composition, chemical structures, and chemical reactions of living things.
The physiological renewal, repair, or replacement of tissue.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
The systematic study of the complete DNA sequences (GENOME) of organisms.
Methods for maintaining or growing CELLS in vitro.
Experimentation on STEM CELLS and on the use of stem cells.
Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.
Specific particles of membrane-bound organized living substances present in eukaryotic cells, such as the MITOCHONDRIA; the GOLGI APPARATUS; ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The systematic study of the complete complement of proteins (PROTEOME) of organisms.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The use of instrumentation and techniques for visualizing material and details that cannot be seen by the unaided eye. It is usually done by enlarging images, transmitted by light or electron beams, with optical or magnetic lenses that magnify the entire image field. With scanning microscopy, images are generated by collecting output from the specimen in a point-by-point fashion, on a magnified scale, as it is scanned by a narrow beam of light or electrons, a laser, a conductive probe, or a topographical probe.
The study of the structure, growth, activities, and functions of NEURONS and the NERVOUS SYSTEM.
Cells that can give rise to cells of the three different GERM LAYERS.
Sequential operating programs and data which instruct the functioning of a digital computer.
Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.
Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
The application of engineering principles and methods to living organisms or biological systems.
Methods utilizing the principles of MICROFLUIDICS for sample handling, reagent mixing, and separation and detection of specific components in fluids.
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.
Established cell cultures that have the potential to propagate indefinitely.
A particular zone of tissue composed of a specialized microenvironment where stem cells are retained in a undifferentiated, self-renewable state.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
Auditory and visual instructional materials.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.
A plant genus of the family CAPPARACEAE that contains cleogynol and 15alpha-acetoxycleomblynol (dammaranes) and 1-epibrachyacarpone (a triterpene), and ISOTHIOCYANATES.
The study of the development of an organism during the embryonic and fetal stages of life.
The protein complement of an organism coded for by its genome.
The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Individuals enrolled in a school or formal educational program.
A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown.
Artificial organs that are composites of biomaterials and cells. The biomaterial can act as a membrane (container) as in BIOARTIFICIAL LIVER or a scaffold as in bioartificial skin.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Time period from 1801 through 1900 of the common era.
Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.
The process that reverts CELL NUCLEI of fully differentiated somatic cells to a pluripotent or totipotent state. This process can be achieved to a certain extent by NUCLEAR TRANSFER TECHNIQUES, such as fusing somatic cell nuclei with enucleated pluripotent embryonic stem cells or enucleated totipotent oocytes. GENE EXPRESSION PROFILING of the fused hybrid cells is used to determine the degree of reprogramming. Dramatic results of nuclear reprogramming include the generation of cloned mammals, such as Dolly the sheep in 1997.
Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young.
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Computer-based representation of physical systems and phenomena such as chemical processes.
A reverse developmental process in which terminally differentiated cells with specialized functions revert back to a less differentiated stage within their own CELL LINEAGE.
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Educational institutions providing facilities for teaching and research and authorized to grant academic degrees.
The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
The educational process of instructing.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Manufacturing technology for making microscopic devices in the micrometer range (typically 1-100 micrometers), such as integrated circuits or MEMS. The process usually involves replication and parallel fabrication of hundreds or millions of identical structures using various thin film deposition techniques and carried out in environmentally-controlled clean rooms.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
Progenitor cells from which all blood cells derive.
A cell line derived from cultured tumor cells.
The study of natural phenomena by observation, measurement, and experimentation.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
The relationships of groups of organisms as reflected by their genetic makeup.
Components of a cell.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The study of fluid channels and chambers of tiny dimensions of tens to hundreds of micrometers and volumes of nanoliters or picoliters. This is of interest in biological MICROCIRCULATION and used in MICROCHEMISTRY and INVESTIGATIVE TECHNIQUES.
Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
The quality of surface form or outline of the CELL NUCLEUS.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Proteins which are involved in the phenomenon of light emission in living systems. Included are the "enzymatic" and "non-enzymatic" types of system with or without the presence of oxygen or co-factors.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP.
The quality of surface form or outline of CELLS.
The life of a person written by himself or herself. (Harrod's Librarians' Glossary, 7th ed)
Recording serial images of a process at regular intervals spaced out over a longer period of time than the time in which the recordings will be played back.
Adherence of cells to surfaces or to other cells.
Local surroundings with which cells interact by processing various chemical and physical signals, and by contributing their own effects to this environment.
Methods for determining interaction between PROTEINS.
Silicone polymers which consist of silicon atoms substituted with methyl groups and linked by oxygen atoms. They comprise a series of biocompatible materials used as liquids, gels or solids; as film for artificial membranes, gels for implants, and liquids for drug vehicles; and as antifoaming agents.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Tomography using x-ray transmission.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
A course of study offered by an educational institution.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The process of finding chemicals for potential therapeutic use.
Basic functional unit of plants.
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
Rapid methods of measuring the effects of an agent in a biological or chemical assay. The assay usually involves some form of automation or a way to conduct multiple assays at the same time using sample arrays.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Elements of limited time intervals, contributing to particular results or situations.
Facilities equipped to carry out investigative procedures.
Cells of the higher organisms, containing a true nucleus bounded by a nuclear membrane.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Assaying the products of or monitoring various biochemical processes and reactions in an individual cell.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The reproductive cells in multicellular organisms at various stages during GAMETOGENESIS.
The interactions between a host and a pathogen, usually resulting in disease.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Databases devoted to knowledge about specific genes and gene products.
Unequal cell division that results in daughter cells of different sizes.
Cells from adult organisms that have been reprogrammed into a pluripotential state similar to that of EMBRYONIC STEM CELLS.
The assessing of academic or educational achievement. It includes all aspects of testing and test construction.
Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. Neural stem cells are precursors to both NEURONS and NEUROGLIA.
The processes whereby the internal environment of an organism tends to remain balanced and stable.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
Orientation of intracellular structures especially with respect to the apical and basolateral domains of the plasma membrane. Polarized cells must direct proteins from the Golgi apparatus to the appropriate domain since tight junctions prevent proteins from diffusing between the two domains.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.
The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; FLUORESCENCE IMAGING; and MICROSCOPY.
The property of emitting radiation while being irradiated. The radiation emitted is usually of longer wavelength than that incident or absorbed, e.g., a substance can be irradiated with invisible radiation and emit visible light. X-ray fluorescence is used in diagnosis.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Acquisition of knowledge as a result of instruction in a formal course of study.
A species of fruit fly much used in genetics because of the large size of its chromosomes.
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
The science and application of a double-beam transmission interference microscope in which the illuminating light beam is split into two paths. One beam passes through the specimen while the other beam reflects off a reference mirror before joining and interfering with the other. The observed optical path difference between the two beams can be measured and used to discriminate minute differences in thickness and refraction of non-stained transparent specimens, such as living cells in culture.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells.
A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.
Morphological and physiological development of EMBRYOS.
Elongated, spindle-shaped, quiescent myoblasts lying in close contact with adult skeletal muscle. They are thought to play a role in muscle repair and regeneration.
Chromosomal, biochemical, intracellular, and other methods used in the study of genetics.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
A tube-like invagination of the EPIDERMIS from which the hair shaft develops and into which SEBACEOUS GLANDS open. The hair follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermis. (Stedman, 26th ed) Follicles of very long hairs extend into the subcutaneous layer of tissue under the SKIN.
A species of nematode that is widely used in biological, biochemical, and genetic studies.
Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
The study of those aspects of energy and matter in terms of elementary principles and laws. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Components of the cytoplasm excluding the CYTOSOL.
Restoration of integrity to traumatized tissue.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
One of the three domains of life (the others being BACTERIA and ARCHAEA), also called Eukarya. These are organisms whose cells are enclosed in membranes and possess a nucleus. They comprise almost all multicellular and many unicellular organisms, and are traditionally divided into groups (sometimes called kingdoms) including ANIMALS; PLANTS; FUNGI; and various algae and other taxa that were previously part of the old kingdom Protista.
Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.
Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
A mechanism of communication with a physiological system for homeostasis, adaptation, etc. Physiological feedback is mediated through extensive feedback mechanisms that use physiological cues as feedback loop signals to control other systems.
The process of germ cell development from the primordial GERM CELLS to the mature haploid GAMETES: ova in the female (OOGENESIS) or sperm in the male (SPERMATOGENESIS).
A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
The performance of dissections, injections, surgery, etc., by the use of micromanipulators (attachments to a microscope) that manipulate tiny instruments.

How cells (might) sense microgravity. (1/414)

This article is a summary of a lecture presented at an ESA/NASA Workshop on Cell and Molecular Biology Research in Space that convened in Leuven, Belgium, in June 1998. Recent studies are reviewed which suggest that cells may sense mechanical stresses, including those due to gravity, through changes in the balance of forces that are transmitted across transmembrane adhesion receptors that link the cytoskeleton to the extracellular matrix and to other cells (e.g., integrins, cadherins, selectins). The mechanism by which these mechanical signals are transduced and converted into a biochemical response appears to be based, in part, on the finding that living cells use a tension-dependent form of architecture, known as tensegrity, to organize and stabilize their cytoskeleton. Because of tensegrity, the cellular response to stress differs depending on the level of pre-stress (pre-existing tension) in the cytoskeleton and it involves all three cytoskeletal filament systems as well as nuclear scaffolds. Recent studies confirm that alterations in the cellular force balance can influence intracellular biochemistry within focal adhesion complexes that form at the site of integrin binding as well as gene expression in the nucleus. These results suggest that gravity sensation may not result from direct activation of any single gravioreceptor molecule. Instead, gravitational forces may be experienced by individual cells in the living organism as a result of stress-dependent changes in cell, tissue, or organ structure that, in turn, alter extracellular matrix mechanics, cell shape, cytoskeletal organization, or internal pre-stress in the cell-tissue matrix.--Ingber, D. How cells (might) sense microgravity.  (+info)

Mapping the literature of cytotechnology. (2/414)

The major purpose of this study was to identify and assess indexing coverage of core journals in cytotechnology. It was part of a larger project sponsored by the Nursing and Allied Health Resources Section of the Medical Library Association to map the literature of allied health. Three representative journals in cytotechnology were selected and subjected to citation analysis to determine what journals, other publication types, and years were cited and how often. Bradford's Law of Scattering was applied to the resulting list of cited journals to identify core titles in the discipline, and five indexes were searched to assess coverage of these core titles. Results indicated that the cytotechnology journal literature had a small core but wide dispersion: one third of the 21,021 journal citations appeared in only 3 titles; another third appeared in an additional 26 titles; the remaining third were scattered in 1,069 different titles. Science Citation Index Expanded rated highest in indexing coverage of the core titles, followed by MEDLINE, EMBASE/Excerpta Medica, HealthSTAR, and Cumulative Index to Nursing and Allied Health Literature (CINAHL). The study's results also showed that journals were the predominantly cited format and that citing authors relied strongly on more recent literature.  (+info)

Antibodies and sperm survival in the female tract of the mouse and rabbit. (3/414)

Rabbit and mouse spermatozoa from male and female tracts have been examined for their species-antigenic surface character, and for adherent antibodies, by double immunofluorescence techniques. Mouse spermatozoa from the ductus deferens showed an area over the acrosome which was positive to anti-mouse serum that had been absorbed with some male mouse somatic tissues including blood, but those from the uterus and oviduct were not stained. Spermatozoa from the uterus were shown to have an antibody coat on the acrosome, with anti-mouse IgG, but those from the ductus deferens and oviduct did not. Rabbit spermatozoa were more variable but their activity was similar: ejaculated spermatozoa sometimes already had antibody of male origin; the majority of the spermatozoa arriving early in the uterus were coated, but in general those that attained the oviducts were not coated. The results are interpreted as evidence for selection by the female tract of a small antigenically different population; the majority of spermatozoa are rejected and/or destroyed.  (+info)

A new miniature hydrostatic pressure chamber for microscopy. Strain-free optical glass windows facilitate phase-contrast and polarized-light microscopy of living cells. Optional fixture permits simultaneous control of pressure and temperature. (4/414)

This paper describes the development of a miniature, temperature-controlled, stainless steel pressure chamber which uses strain-free optical glass for windows. It is directly adaptable to standard phase-contrast and polarized-light microscopes and requires a minimum amount of equipment to generate and measure pressure. Birefringence retardation (BR) og 0.1 nm up to 3,000 psi, 0.4 nm up to 5,000 psi and 1.0 nm up to 10,000 psi can be detected over a 0.75-mm central field with two strain-free Leitz 20 times UM objectives, one used as a condenser. In phase-contrast studies a Nikon DML 40 times phase objective and Zeiss model IS long working-distance phase condenser were used, with little deterioration of image quality or contrast at pressures as high as 12,000 psi. The actual design process required a synthesis of various criteria which may be categorized under four main areas of consideration: (a) specimen physiology; (b) constraints imposed by available optical equipment and standard microscope systems; (c) mechanical strength and methods for generating pressure; and (d) optical requirements of the chamber windows. Procedures for using the chambers, as well as methods for shifting and controlling the temperature within the chamber, are included.  (+info)

Prototype Web-based continuing medical education using FlashPix images. (5/414)

Continuing Medical Education (CME) is a requirement among practicing physicians to promote continuous enhancement of clinical knowledge to reflect new developments in medical care. Previous research has harnessed the Web to disseminate complete pathology CME case studies including history, images, diagnoses, and discussions to the medical community. Users submit real-time diagnoses and receive instantaneous feedback, eliminating the need for hard copies of case material and case evaluation forms. This project extends the Web-based CME paradigm with the incorporation of multi-resolution FlashPix images and an intuitive, interactive user interface. The FlashPix file format combines a high-resolution version of an image with a hierarchy of several lower resolution copies, providing real-time magnification via a single image file. The Web interface was designed specifically to simulate microscopic analysis, using the latest Javascript, Java and Common Gateway Interface tools. As the project progresses to the evaluation stage, it is hoped that this active learning format will provide a practical and efficacious environment for continuing medical education with additional application potential in classroom demonstrations, proficiency testing, and telepathology. Using Microsoft Internet Explorer 4.0 and above, the working prototype Web-based CME environment is accessible at  (+info)

A brief history of the Japan Society for Cell Biology. (6/414)

The Japan Society for Cell Biology (JSCB) was first founded in 1950 as the Japan Society for Cellular Chemistry under the vigorous leadership of Seizo Katsunuma, in collaboration with Shigeyasu Amano and Satimaru Seno. The Society was provisionally named as above simply because cell biology had not yet been coined at that time in Japan, although in prospect and reality the Society was in fact for the purpose of pursuing cell biology. Later in 1964, the Society was properly renamed as the Japan Society for Cell Biology. After this renaming, the JSCB made great efforts to adapt itself to the rapid progress being made in cell biology. For this purpose the Society's constitution was created in 1966 and revised in 1969. According to the revised constitution, the President, Executive Committee and Councils were to be determined by ballot vote. The style of the annual meetings was gradually modified to incorporate general oral and poster presentations in addition to Symposia (1969-1974). The publication of annual periodicals in Japanese called Symposia of the Japan Society for Cellular Chemistry (1951-1967) and later Symposia of the Japan Society for Cell Biology (1968-1974) was replaced by a new international journal called Cell Structure and Function initiated in 1975. This reformation made it possible for the Society to participate in the Science Council of Japan in 1975 and finally in 1993 to acquire its own study section of Cell Biology with grants-in-aid from the Ministry of Education and Science, Japan. The JSCB hosted the 3rd International Congress on Cell Biology (ICCB) in 1984 and the 3rd Asian-Pacific Organization for Cell Biology (APOCB) Congress in 1998, thus contributing to the international advancement of cell biology. Now the membership of JSCB stands at approximately 1,800 and the number of presentations per meeting is 300 to 400 annually. Although a good number of interesting and important findings in cell biology have been reported from Japan, the general academic activity of the JSCB is far less than one might expect. This is simply due the fact that academic activity in the field of cell biology in Japan is divided among several other related societies such as the Japan Society for Molecular Biology and the Japan Society for Developmental Biology, among others.  (+info)

Myocardial lysis in acute rheumatic fever followed by regeneration of cardiac muscle and origin of Aschoff bodies. (7/414)

In acute rheumatic heart disease, lysis of cardiac muscle fibres with or without retention of sarcolemma is found to be the most damaging feature in many cases. In deeper myocardium the cellular lysis often forms anastomosing clefts or sinus-like spaces between surviving muscle bundles and in the outer portion of myocardium cellular lysis may leave the sarcolemma more or less intact. From lysing cardiac muscle fibres there arise dedifferentiated cells with remarkable potentiality for regeneration. For the origin of these dedifferentiated cells, which are often indistinguishable from lymphocytes, no mitosis is seen in cardiac muscle cells. The successive stages of development of muscle cell from these dedifferentiated cells within the remaining or newly formed sarcolemma have been observed in this study. This study infers that the increased number of fibrous septa, when seen, denotes the tracks of previous muscle degeneration and subsequent replacement of it with incomplete muscle regeneration and fibrous tissue formation. In an area of muscle lysis the origin of Aschoff bodies from these dedifferentiated cells has been followed. Ashoff bodies arising in this was behave as an abortive and atypical growth of muscle fibres in a nodular fashion specific to rheumatic fever.  (+info)

Papanicolaou tests diagnosed as atypical by a cytotechnologist and downgraded to benign by a pathologist: a measure of laboratory quality. (8/414)

Follow-up of Papanicolaou (Pap) tests diagnosed as atypical squamous cells of undetermined significance (ASCUS) or atypical glandular cells of undetermined significance (AGUS) by a cytotechnologist and downgraded to benign by a pathologist has not been measured. Squamous intraepithelial lesion (SIL) follow-up rates were obtained for Pap tests diagnosed as ASCUS (288) or AGUS (94) and downgraded to benign and for Pap tests diagnosed as repair (231). Statistically significant associations were seen between 7 cytotechnologists and between 7 pathologists and ASCUS, AGUS, downgraded ASCUS, and downgraded AGUS rates. The percentage of downgraded ASCUS cases compared with all ASCUS cases per pathologist ranged from 4.8% to 43.7%. Statistically significant associations between pathologists and SIL follow-up rates for downgraded ASCUS diagnoses were seen. The SIL follow-up rate for repair (7.9%) was similar to that for a downgraded ASCUS (11.0%) or AGUS (7.3%). The parameters of downgraded ASCU and AGUS Pap test interpretations are good quality indicators of individual performance and overall laboratory quality.  (+info)

The Imaris for Cell Biologists package is ideal for researchers in several life science disciplines who require a broad range of functionalities to study cells and organisms. In addition to Imaris proven 3D/4D visualization and analysis tools, Imaris for Cell Biologists provides the functionality for smart cell based segmentation, analysis on a per cell basis and discovery of intracellular relationships. The package includes automated tracking, detection of cell division and creation of interactive lineage trees along with statistical tests and a two-way interface for customization in Matlab, Java or Python.. Request Pricing ...
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Cytologists and cell biologists are both focused on cancer cells, yet there is very little cross-talk between these two fields. This session aims to create common ground through an in-depth description of the cell biology basis of cytologists criteria of malignancy. This session will be useful for cytologists who wish to collaborate or work in cancer research, and for educators who want to stay abreast of the rapid developments in research related to cytology. In addition to facilitating communication and collaboration, it is our experience that an understanding of the cell biology basis for morphologic changes helps reinforce a thorough understanding of the criteria of malignancy. This session therefore should have appeal for cytologists at all levels of experience-from beginners who want to learn or reinforce diagnostic concepts to senior cytologists who want to know the latest developments in the histone code or anoikis mechanisms. The session would also be useful for cell biologists who may ...
Health, ...Cancer and cell biology experts at the University of Cincinnati (UC) h...The study led by Jorge Moscat PhD appears in the January 2009 issue...Proto-oncogenes are genes that play a role in normal cell growth (turn...UC researchers sought to define the interim steps that occur in Ras-in...,Cell,biologists,identify,new,tumor,suppressor,for,lung,cancer,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Because cell biologists seek to understand how cells function both under normal conditions and in disease states such as cancer, cystic fibrosis, diabetes and muscular dystrophy, the CDB emphasis constitutes a middle road for those planning medical careers. In addition to the standard techniques of biochemistry and molecular biology, cell biologists employ a powerful array of optical and physiological techniques to measure and manipulate the location and concentration of ions and molecules within living cells and subcellular organelles, and even the forces exerted by cells on their surroundings ...
Box 1. Determining the quality of a TIRF set up. The test samples described below can be used to check the quality of any TIRF set up. They should always be prepared using a cover slip with the correct thickness and refractive index for the objective.. Test samples. Fluorescent microbeads. These can be purchased from many sources, including Invitrogen (Carlsbad, CA) and Bangs Laboratories (Fishers, IN). The beads should be of subresolution size (100 nm diameter or less), and selected to have excitation and emission spectra that match typical experimental conditions. The beads should be diluted in water and applied to the cover slip. PBS can be added to increase the number of beads that adhere to the surface.. DiI. A convenient, uniform, fluorescent film can be easily made on a cover slip surface with the lipophilic fluorophore DiI (Invitrogen, Carlsbad, CA). Dissolve the DiI at 0.5 mg/ml in ethanol and place a single droplet of the solution on a glass cover slip. Then, before the solution dries, ...
The two went to Woods Hole to see if Bob and Anne Goldmans antibodies to mammalian cytoskeletal proteins would recognize yeast proteins. By chance, Kilmartin was there with his new monoclonal antitubulin antibody, which he had already managed to get into spheroplasts. The spheroplasts showed good IF, but had lost the original cells shape and organization. We decided to try to fix the cells before removing the cell wall, Adams recalls. It worked. It was exciting to see cytoplasmic microtubules in yeast that are hard to see by EM, but by IF they really stood out.. IF tools now in hand, Adams and Pringle returned to the University of Michigan (Ann Arbor, MI), and Kilmartin to the MRC Laboratory of Molecular Biology (Cambridge, UK) to delve further into the roles of actin and microtubules. Kilmartin examined actin by IF while Adams stained it with the newly available fluorescent phalloidin.. In two papers, they described the distribution of actin in cortical patches and cytoplasmic cables that ...
Peter Novick, Ph.D., whose groundbreaking work in the field of cell biology has contributed to a novel understanding of internal cellular transportation systems, has been named the George E. Palade Endowed Chair of Cellular and Molecular Medicine at the UC San Diego School of Medicine. Novick joins UC San Diego from Yale University, where he was a professor in the Department of Cell Biology at the School of Medicine for more than 20 years. He is a member of the American Academy of Arts and Sciences.
I believe that as a society, we see heroes as individuals who are extremely bright and special, but who go solo and owe little to the majority of people around them. I believe we also perceive dependence on teamwork as a vulnerability instead of an enhancement of any single individual capacity to reach a goal. Thus, the quality I admire in my scientific heroes is the genuine recognition of their dependence on their team members as well as their projected perception that their incredible discoveries and (scientific) accomplishments are the result of an interdependent community.. What do you like to read, learn, or think about outside of lab?. I think a lot about biases and how they can affect my thinking and behaviors. I also love playing or listening to music and have Pandora to inform me of new bands/songs.. Are there any causes or initiatives in or outside of science that you are particularly passionate about?. Being both an immigrant and a woman I tend to think a lot about diversity. It has ...
Medical Xpress is a web-based medical and health news service that features the most comprehensive coverage in the fields of neuroscience, cardiology, cancer, HIV/AIDS, psychology, psychiatry, dentistry, genetics, diseases and conditions, medications and more.
Medical Xpress is a web-based medical and health news service that features the most comprehensive coverage in the fields of neuroscience, cardiology, cancer, HIV/AIDS, psychology, psychiatry, dentistry, genetics, diseases and conditions, medications and more.
Molecular and Cell Biologists (Biochemists, Microbiologists, Cell Biologists…) at the US Food and Drug Administration: We DO Play an Important Role (and, No, We Dont Do the Same Thing Every Day ...
Cell biologist Danesh Moazed, physicist Michael Raymer, and naturalist Chris Lay are being honored by the UC Santa Cruz Division of Physical and Biological Sciences (PBSci) as the recipients of the PBSci Distinguished Alumni Awards.. The division established the awards to honor graduates of the division who have gone on to extraordinary accomplishments in diverse fields and whose careers are characterized by sustained and exemplary contributions to society through research, practice, education, policy, or service.. Danesh Moazed. Danesh Moazed is a professor of cell biology at Harvard Medical School and a Howard Hughes Medical Institute investigator. He received both his undergraduate and graduate degrees at UC Santa Cruz, earning a B.A. in biology and Ph.D. in biology. He worked with Harry Noller, the Sinsheimer Professor of Molecular Biology, to investigate the structure and function of the ribosome, and this research led to a remarkable 17 publications.. Moazeds postdoctoral research at UCSF ...
Originally From: George Zachos ,gzachos at, Job Vacancy: Postdoctoral Research Scientist Genetic and molecular analysis of Chk1 functions in the mitotic spindle checkpoint and cytokinesis Prof George Zachos Starting date: 1 October 2008. 3-year fixed-term contract. Salary will depend on experience. The Cell Cycle and Division Laboratory of the Department of Biology, University of Crete is interested in understanding the mechanisms of cell cycle checkpoints triggered by DNA damage, inhibition of DNA replication and spindle poisons (Zachos et al, EMBOJ 22: 713-723, 2003- Zachos et al, Mol. Cell. Biol. 25: 563-574, 2005). Recently, we were the first to show that Chk1 protein kinase, a well-established component of the DNA damage checkpoint, is also required for the mitotic spindle checkpoint (Zachos et al, Dev Cell 12: 247-260, 2007). We are seeking a highly motivated and dedicated postdoctoral research scientist to further explore this novel role of Chk1 in mitosis by investigating ...
Many adult tissues are renewed from small populations of stem cells, which continually replace differentiated cells lost to damage or age. Since tissue stem cells are highly dependent on signals from their local microenvironments, or niches, understanding how niches work is important for manipulating regeneration. To answer this question, the Matunis lab combines genetics, live imaging, and genome-wide approaches to understand how the germline and somatic cells in the testis that create and reside in the testis niche cooperatively ensure a lifetime supply of sperm. ...
An area that has seen the successful integration of theory and experiment is the cell cycle. Many of the discoveries in cell‐cycle research have been made by studying unicellular yeast species in which the cell cycle is controlled by a complex network that integrates signals both from within the cell and from the surrounding environment. The giant African frog Xenopus laevis, which lacks genetics tools and must choreograph mitosis with the development of a metazoan body plan, would at first glance appear to be an unpromising organism for gaining quantitative insight into the cell cycle. However, it is in this system that Ferrell and colleagues have produced fascinating work on the key components of the eukaryotic cell‐cycle network.. A feature of X. laevis that makes it particularly amenable to quantitative studies is that the first 12 cleavages of the early embryo occur synchronously and at regular intervals of around half an hour. These blastomere cells seem to lack most, if not all, of ...
Professor James Rothman, the Wallace Professor of the Biomedical Sciences at Yale University, is one of the worlds most distinguished biochemists and cell biologists. He is Chairman of the Yale School of Medicines Department of Cell Biology and is the Director and founder of the Nanobiology Institute on Yales new West Campus. Rothman graduated from Yale College (1971) where he studied physics. He received his Ph.D. degree in biological chemistry from Harvard (1976) and was a student at Harvard Medical School from 1971 to 1973. From 1976 to 1978, he completed a fellowship in the Department of Biology at the Massachusetts Institute of Technology. From 1978 to 1988, he was a professor in the Department of Biochemistry at Stanford University. Dr. Rothman was the E.R. Squibb Professor of Molecular Biology at Princeton University (1988-1991). He founded and chaired the Department of Cellular Biochemistry and Biophysics at Memorial Sloan-Kettering Cancer Center (1991-2004), where he held the Paul A. ...
Professor James Rothman, the Wallace Professor of the Biomedical Sciences at Yale University, is one of the worlds most distinguished biochemists and cell biologists. He is Chairman of the Yale School of Medicines Department of Cell Biology and is the Director and founder of the Nanobiology Institute on Yales new West Campus. Rothman graduated from Yale College (1971) where he studied physics. He received his Ph.D. degree in biological chemistry from Harvard (1976) and was a student at Harvard Medical School from 1971 to 1973. From 1976 to 1978, he completed a fellowship in the Department of Biology at the Massachusetts Institute of Technology. From 1978 to 1988, he was a professor in the Department of Biochemistry at Stanford University. Dr. Rothman was the E.R. Squibb Professor of Molecular Biology at Princeton University (1988-1991). He founded and chaired the Department of Cellular Biochemistry and Biophysics at Memorial Sloan-Kettering Cancer Center (1991-2004), where he held the Paul A. ...
The Department of Anatomy and Cell Biology takes pride in the scientific education of its graduate students and aims to provide them with broad experience in cell and molecular biology as a prelude to a productive research career. The research interests of the department span many facets of cell and developmental biology. The department has placed particular emphasis on development and developmental neurobiology in areas including development of the enteric nervous system, development and subunit composition of nicotinic acetylcholine receptors, migration of neurons during development of the nervous system, axonal transport, and muscle development. There is a related research program that takes advantage of the development and genetics of the lower eucaryotes Dictyostelium and yeast to ask questions about pattern formation, chemotaxis, organelle inheritance and DNA repair. The department is also home to cell biologists interested in microtubule dynamics, cell motility, cell cycle regulation, ...
Researchers have solved a question that has puzzled cell biologists for decades: how does the protein machine that allows cells to swallow up molecules during endocytosis function?
Cell biologists will enjoy any of these gifts featuring all of the key components of a eukaryotic cell along with the following saying: Cell Culture Inside.. ...
Cell biologists have long thought that cytokinesis, the final step of cell division in which the cytoplasm and its contents are split, is necessary for the proper assortment of chromosomes. Disrupt this process, the prevailing wisdom held, and aneuploidy will result, with cancerous implications. But a team led by Mark Burkard at the University of Wisconsin-Madison has discovered a new type of cell division, dubbed klerokinesis, that protects cells from failed cytokinesis.. Using live-cell imaging, the researchers watched retinal pigment epithelial cells for five days after they had chemically inhibited cytokinesis. Reporting today at the American Society for Cell Biologys annual meeting in San Francisco, they showed that many cells managed to split into two during the first growth phase of the next cell cycle-not during mitosis-allowing each to recover a normal chromosome set. Burkard says that therapeutic strategies that boost this type of nonmitotic cell fission could prevent cancer in ...
Bruce H. Lipton, PhD is an internationally recognized leader in bridging science and spirit. Stem cell biologist, bestselling author of The Biology of Belief and recipient of the 2009 Goi Peace Award, he has been a guest speaker on hundreds of TV and radio shows, as well as keynote presenter for national and international conferences. He has been a guest speaker on hundreds of TV and radio shows, as well as keynote presenter for national and international conferences.Dr. Liptons novel scientific approach transformed his personal life as well. His deepened understanding of cell biology highlighted the mechanisms by which the mind controls bodily functions, and implied the existence of an immortal spirit. He applied this science to his personal biology, and discovered that his physical well-being improved, and the quality and character of his daily life was greatly enhanced.
Schulich Medicine & Dentistry received a financial boost in the quest to demonstrate how stem cells sourced from your bodys fat can assist in wound healing and musculoskeletal regeneration.. Thanks to new funding announced today through the Canada Foundation for Innovations (CFI) John R. Evans Leaders Fund, Lauren Flynn, PhD, an Associate Professor in the Department of Anatomy & Cell Biology at the Schulich School of Medicine & Dentistry and the Department of Chemical & Biochemical Engineering in the Faculty of Engineering, will be able to invest in infrastructure to continue her cutting-edge research in this area.. The CFI funding is a major boost for our collaborative research programs and will allow us to purchase the key infrastructure that we need to be able to make high-impact contributions to understanding the key factors that mediate soft tissue regeneration, said Flynn.. Today, the Honourable Ed Holder, Minister of State (Science and Technology), announced more than $35 million in ...
Group Leader and Head of Biochemistry Division at the Netherlands Cancer Institute, Professor at Erasmus MC Rotterdam, The Netherlands.. Prof. Sixmas research group studies ubiquitin conjugation/deconjugation and DNA repair using a combination of structural methods and biochemistry to understand basic cellular processes. Her aim is to understand structural aspects of the errors that occur in cell biology that lead to cancer development. A major aspect of Prof. Sixmas work uses protein crystallography, biochemical and biophysical techniques to understand the catalytic activities of deubiquitylating enzymes (DUBs) and how they are regulated by protein partners, cofactors and other domains outside the DUB catalytic subunit. She also collaborates with cell biologists to improve understanding of carcinogenesis as well as the molecular mechanisms that could provide a basis for novel and/or improved drug design.. ...
A new finding by Harvard stem cell biologists turns one of the basics of neurobiology on its head - demonstrating that it is possible to turn one type of already differentiated neuron into another within the brain.. The discovery by Paola Arlotta and Caroline Rouaux tells you that maybe the brain is not as immutable as we always thought, because at least during an early window of time one can reprogram the identity of one neuronal class into another, said Arlotta, an Associate Professor in Harvards Department of Stem Cell and Regenerative Biology. The work is published online in the journal Nature Cell Biology.. ...
Division of Anatomy and Cell Biology at Rush University provides on-going educational opportunities to those students seeking advanced degrees.
Youre a quantitative person and you want to learn biology. My friend, you are in a difficult situation. If you really want to learn how biology works in a big-picture sense, as opposed to cutting yourself a very narrow slice of the great biological pie, then you have a challenging road ahead of you. Fortunately, many have walked it before you, and I want to give you some advice based on my own experiences. I should say at the outset that my own learning has focused mostly on the cell-biology part of the pie - not physiology, zoology, ecology, … and so my comments here refer to learning cell biology.. The scary thing is that I have been at this for almost 20 years (very part-time admittedly) and I would never dare to call myself a cell biologist. But I think its fair to say that by now I have a decent sense of what I know and what I dont know. I will never be able to draw out the Krebs cycle, but I have a qualitative sense of its purpose and importance, as well as of general principles of ...
Here is the best resource for homework help with PCB 4023 : Molecular and Cell Biology at FAU. Find PCB4023 study guides, notes, and practice tests from FAU.
The New York Stem Cell Foundation (NYSCF) Research Institute is a growing and successful nonprofit whose mission is to accelerate cures through stem cell research. NYSCF is seeking an Associate Scientist/Scientist to join the Functional Genomics team. This position reports directly to the Sr. Staff Scientist, and works closely with other members of the NYSCF Research Institute including: stem cell biologists, bioinformatician, software developers, bioinformatics, and operations.
Brukers suite of fluorescence microscopy systems provides a full range of solutions for life science researchers. Our multiphoton imaging systems provide the imaging depth, speed and resolution required for intravital imaging applications in neuroscience, oncology and immunology. Our confocal systems enable cell biologists to study function and structure using live-cell imaging in cell cultures and invertebrate model organisms at speeds and durations previously not possible. Brukers super-resolution microscopes are setting new standards with quantitative single molecule localization which allows for the direct investigation of the molecular positions and distribution of proteins within the cellular environment. Our latest addition, Luxendo light-sheet microscopes, are revolutionizing long-term studies in developmental biology and investigation of dynamic processes in cell culture and small animal models. ...
This application proposes to continue and expand our CIRM-funded integrated training and research program in the fundamental biology of embryonic, adult, and reprogrammed-stem cell research and its applications to human disease. We aim to produce leaders positioned to understand basic stem cell mechanisms, develop relevant human stem cell lines in order to investigate the pathogenesis and treatment of diseases, and provide the fundamental and practical basis for the development of new molecular and cellular therapies. These activities have significant implications for the State of California and its citizens. We are requesting CIRM funds in order to continue our highly successful Research Training Program, with 6 predoctoral, 5 post-doctoral and 5 clinical fellow trainees for a total of 16 concurrent CIRM Scholar positions. Trainees will have the opportunity to learn from pre-eminent stem cell biologists as well as physicians, scientists and physician-scientists at one of the States leading ...
In a new study from stem cell biologists at the RIKEN Center for Developmental Biology, scientists demonstrate self-formation of optic cups and storable stratified neural…. ...
2Institute of Protein Research, Russian Academy of Sciences, Pushchino, Russia. Alternative splicing is an important regulatory mechanism in higher eukaryotes. By recent estimates, at least 30% of human genes are spliced alternatively (1). Alternative splicing plays a major role in sex determination in Drosophila, antibody response in humans and other tissue or developmental stage specific processes. The database of alternatively spliced genes can be of potential use for molecular biologists studying splicing, developmental biologists, geneticists, and cell biologists. We have created a public Alternative Splicing Database (ASDB) (2) for the biological community as a repository of data on alternatively spliced genes. ASDB is currently available at the URL The administrator of the database can be contacted by Email: [email protected] Our original set of 1663 proteins was generated by selecting all SwissProt entries containing the words alternative splicing. ...
This volume inspires. It certainly will be much appreciated by cell biologists all over the world. Quarterly Review of Biology, March 2009 This book is the eagerly awaited second edition of the best-selling Mitochondria, a book widely acknowledged as the first modern, truly comprehensive authored work on the important, scientifically fundamental topic of the cellular organelles known as mitochondria. This new edition brings readers completely up to date on the many significant findings that have occurred in the eight years since the book was first published. As in that seminal first edition, the second edition tackles the biochemistry, genetics, and pathology of mitochondria in different organisms. The new edition provides thorough updates of all literature concerning this vital organelle, its functions, ongoing research surrounding it, and its importance vis- -vis a broad range of issues in cellular and molecular biology. The book includes detailed descriptions of current and developing technologies
A new method of imaging cells is allowing scientists to see tiny structures inside the control centre of the cell for the first time.. The microscopic technique, developed by researchers at Queen Mary University of London, represents a major advance for cell biologists as it will allow them to investigate structures deep inside the cell, such as viruses, bacteria and parts of the nucleus in depth.. Recent advances in optical physics have made it possible to use fluorescent microscopy to study complex structures smaller than 200 nanometres (nm) - around 500 times smaller than the width of a human hair. These methodologies are called super-resolution microscopy.. The drawback of such techniques is that they can only produce very clear images of structures that are at the bottom of the cell. Since the nucleus - the cells control centre - is in the middle of the cell and bacterial and viral infections can happen anywhere in the cell, this technique has considerable limitations for ...
One of The Hormel Institutes research leaders is targeting childhood brain cancer under a new project recently approved for federal funding.. Dr. Edward Hinchcliffe, leader of the Cellular Dynamics research section at The Hormel Institute, University of Minnesota, has been awarded a two-year grant totaling nearly $422,000 from the U.S. Department of Defense. Under the grant, Hinchcliffes team seeks to better understand one potential cause of pediatric brain cancer: mistakes made during cell division or mitosis (one cell becoming two) that cause rearrangements of chromosomes called chromosome instability.. Hinchcliffe, a basic cell biologist who is an expert microscopist (research using microscopes) and leader in the field of live-cell imaging, will run experiments to gain knowledge of how mistakes during cell division can contribute to brain cancer progression in children and, most importantly, seek to identify cellular mechanisms linked to gene mutations seen in patients. Several recent ...
Epithelial Cell Culture A Practical Approach Is A Timely And Comprehensive Practical Guide For All Researchers Who Are Studying Or Intend To Study Epithelia Related Tissues Using Modern Cell Culture Techniques As Such This Book Will Have A Very Wide Appeal To Cell Biologists Developmental Biologists Biochemists Pharmaceutical Scientists
Merging two disparate technologies, a team of chemists and engineers created a revolutionary new tool for cell biologists In 2001, just as a new scientific field called systems biology was emerging, Toronto chemist Dr. Scott Tanner, who was working in private industry, happened to meet biologist Dr. John Dick, a senior scientist at the citys University Health Network. It was
The conference opened with a key note lecture delivered by Professor Jen Sheen, who began in contrast to the typical fashion of justifying why plant science is important, by displaying some of her own craftsmanship of photography and horticulture, to instead remind us how diverse and beautiful plants really are. Professor Sheen has spent much of her career delving into the world of how sugars, mainly glucose and also nitrates, act as a signalling molecules in plants. Dissecting this process is truly an interesting topic for a cell biologist, these processes are important to organisms at a multitude of levels, and critically they are not static, and are among a tangle of interconnections. Professor Sheens description of these processes made for an excellent talk at the cutting edge of molecular biology.. In organellar biology I was excited to meet Dr. Jesse Woodson, who presented the findings of his recent Science paper (Woodson JD, et al. 2015. Science 350:450-4) together with some previously ...
This perspective tackles the issues facing developmental biologists and cell biologists regarding how the molecular mechanisms for specifying cell fate are defined. This perspective focuses on members of the Wnt family. The author proposes that Wnt proteins may act as stabilizing signals for earlier inductive events in certain systems, for example, in Caenorhabditis elegans during the migration of two neurons and in Drosophila melanogaster during the patterning of the wing.
It has been unclear thus far how the two bacterial effectors Tir and EspFU enter into contact with one another in the host cell, says Theresia Stradal. Her research group has now found the missing link: The molecule comes from the host cell, is called IRSp53 and gathers on the cell surface, directly beneath the bacteria sitting on it, explains cell biologist Markus Ladwein, who is also involved in the project. IRSp53, then, establishes the connection between Tir and EspFU. It ensures that actin conversion is concentrated locally. Together with the biochemist Dr. Stefanie Weiß, a former post-graduate student with the research group, Markus Ladwein also provided the counter evidence: Cells in which IRSp53 is lacking are no longer able to form pedestals for the bacteria ...
At NIMR Medawar turned his attention to investigating the immunosuppressive qualities of ALS, as mentioned in the previous section. He encouraged and supported scientists at the Institute and recruited an additional number working in disciplines caught up in the spin-out of immunological ideas and questions. It was a heady time. I joined at the end of 1968, and started collaborative experiments contributing to the definition of phenotypically and functionally different subpopulations of T cells [39-41]. I was caught up in the ferment in which microbiologists, cell biologists, physiologists, biochemists, as well as research clinicians in various specialities, moved in and out of each others laboratories talking about ideas and results. These conversations continued during lunch and coffee breaks, and in the bar at the end of the day. I was encouraged to try new in vitro approaches to cell-mediated immunity. I went to the National Institutes of Health (NIH) where I gained experience of growing ...
An educational app created at the University of Alberta is giving cell biology students a brand new perspective on their subject and may also offer a glimpse into the not-so-distant future of post-secondary education.. The Cell 101 VR App shows students a virtual reality perspective of the inner workings of cells and their interactions, allowing them to visualize cell biology in a way they never could before.. Everything that cells do is because of their internal machinery, but how this machinery is constructed from proteins and other biomolecules is very hard for students to conceptualize, said Paul LaPointe, an associate professor of cell biology at the U of A who helped create the application. He said its a difficult concept to illustrate and contextualize, making it difficult for students to understand that when a drug does something in the cell, its because it fits in the recesses of the proteins inside, preventing them from taking a mechanical action. If you can tap into their ...
Management Committee Substitute. George Dickson is Professor of Molecular Cell Biology at Royal Holloway - University of London (RHUL). He has spent most of his career studying neuromuscular disease and muscle cell biology, including the first cloning of an intact dystrophin gene, the discovery of the role of cell adhesion molecules in muscle stem cell fusion, the first identification of utrophin, and the first description of exon skipping in Duchenne muscular dystrophy (DMD). Professor Dickson has also conducted notable research into gene therapy for atherosclerosis, and genetic vaccination against HIV/AIDS. He is a member of the UK MDEX Consortium, UK HIV-Vaccine Consortium, and the EU-SKIP-NMD Project, and has been a platform leader in the EU Clinigene Network of Excellence. He is a past President of the European Society of Gene & Cell Therapy, and a past Secretary and founder member of the British Society for Gene Therapy. He has been a member of the European Medicine Agency Committee for ...
Were coming to the time of year again when breast cancer awareness month approaches, pink ribbons plaster our cities, thousands gather to walk or run for stricken loved ones and we hope for a cure . . . someday . . . of this deadly disease destroying our mothers, sisters, aunts, grandmothers, friends. Whats the mainstream thought of beating the odds of breast cancer? It is early detection - yearly mammograms and self exams.. Did you know that according to the National Cancer Institute (NCI), about 13.2 percent of women in the general U.S. population will develop breast cancer? After millions of your [1. National Cancer Institutes (NCI) Surveillance, Epidemiology, and End Results (SEER) Program, SEER Cancer Statistics Review, 1975-2002.] dollars have been put into research and solutions, they are finding that their early detection tests are actually causing more cancer.. Paul Yaswen, a cell biologist and breast cancer research specialist with Berkeley Labs Life Sciences Division, said ...
The Bio-Web: Resources for Molecular and Cell Biologists keeps a single, adaptive book Utopianism and with the human conversation of creating & to systems-level sponsor over the tissue. approaches: instance sports, Applicable sense, tissue environment, study and Racial biotechnology, bio, Growth transcription response, real Anesthesia sister, grade advisors, emotional education, linux, design, space brain, loads, time graduate, residence life, description motor for specialization, user and purpose program credit. All tables and students in this translation are relation of their Differentiated source. The address(es provide information of their minutes. class principles: Bioinformatics FAQ - Macintosh Software for Molecular Biology - Rotating DNA. depth: When hatching a new functionality, developmental statements want to matters with loans and attitudes. challenges and interpreters need one important to install the units between products in a Lab that chapters, for Biology, ok usually. The ...
Actin-based cell motility and force generation are central to immune response, tissue development, and cancer metastasis, and understanding actin cytoskeleton regulation is a major goal of cell biologists. Cell spreading is a commonly used model system for motility experiments - spreading fibroblasts exhibit stereotypic, spatially-isotropic edge dynamics during a reproducible sequence of functional phases: 1) During early spreading, cells form initial contacts with the surface. 2) The middle spreading phase exhibits rapidly increasing attachment area. 3) Late spreading is characterized by periodic contractions and stable adhesions formation. While differences in cytoskeletal regulation between phases are known, a global analysis of the spatial and temporal coordination of motility and force generation is missing. Implementing improved algorithms for analyzing edge dynamics over the entire cell periphery, we observed that a single domain of homogeneous cytoskeletal dynamics dominated each of the three
287,823. This proposal will fund two new stem cell courses at Binghamton University. The Fall 2010 course, The Biotechnology of Stem Cells, will be taught by Professor Robert Van Buskirk, a cell biologist/tissue engineer who developed EpiDerm, a commercially successful stem cell-derived, human skin used worldwide for scar management. This course, limited to junior and senior biology majors, will include oral presentations of stem cell companies history, underlying science, products and market potential, and a requirement to write an NIH SBIR (small business) grant focused on stem cells. The companion Fall 2011 course, The Commercialization of Stem Cells, will be taught by Professor John Baust, a cell biologist/cryobiologist who developed commercially successful stem cell transport solutions now used internationally for shipping human stem cells for cell therapy. This course, offered to both undergraduate business and science (non-biology) majors, will include a tutorial on cell biology and ...
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Dear friends, collaborators, relatives and other potential partners in my misery, HEEEELP! My apologies for bugging all of you with this, but I assume that many of you might have gone through pains I am just about to experience. Hence, my hope that you may be able, and willing, to help. Thank you in advance. I will be putting together a LABORATORY cell biology course for 3rd, preferably 4th year undergraduate students. I expect a class of in between 30 and MAXIMUM 50 students. I would appreciate suggestions on what type experiments one can design for such a class? I would prefer students DO experiments and not WATCH them being done. I presume that the class could be split into three groups if such need arises. We have at hand two c-focal microscopes, four wide-field fluorescence microscopes, and quite a number of standard student-type bright field microscopes. Of course, the experiments do not have to be restricted to microscopy, a simple, student-performed dissctions followed by tissue culture, ...
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Dr Victoria Cowling, of the University of Dundee, has been awarded the inaugural Women in Cell Biology Early Career Award Medal by the British Society for Cell Biology.. The Medal has been established to mark the 50th anniversary of the founding of the BSCB. It will be an annual honour awarded to an outstanding female cell biologist who has started their own research group in the UK within the last seven years.. Dr Cowling is based in the Medical Research Council Protein Phosphorylation and Ubiquitylation (MRC-PPU) Unit in the College of Life Sciences at Dundee. Her research aims to find new methods of killing cancer cells by targeting how proteins are made.. I am delighted that our research has received this recognition from the British Society for Cell Biology, said Dr Cowling.. Dr Cowling recently made a major molecular discovery about how genes are regulated and how mutations in cancer genes promote unrestrained cell growth which can result in tumour formation.. Last year she was awarded a ...
As a microbiologist and cell biologist, Dr. Heindls research focuses on the prokaryotic development and bacterial interactions within the environment. He uses the plant pathogen Agrobacterium tumefaciensand related bacteria to understand regulatory principles and molecular mechanisms governing bacterial developmental stages from growth and remodeling, to the morphogenesis, division, and biofilm formation. His work has been published in several renowned scientific journals, such as Journal of Bacteriology, Infection and Immunity, and PLOS ONE-a peer-reviewed open access scientific journal published by the Public Library of Science. In his new role, Dr. Heindls responsibilities include teaching a variety of undergraduate microbiology courses and developing new courses for the program. He is also charged with establishing an active research program with undergraduate and graduate students in the Department of Biological Sciences. Dr. Heindl, a native of Indian Harbour Beach, Florida, received his ...
The Department of Biology at Rollins College invites applications for two one year, visiting assistant professor of biology positions beginning August 2017. We are seeking a broadly trained geneticist and a cell biologist. The successful candidates will have a demonstrated commitment to teaching excellence in a liberal arts institution. Teaching responsibilities will include genetics or cell biology, participating in our team-taught Introductory Biology series for majors, and teaching a general education course for non-science majors. Ph.D. in the biological sciences required, and postdoctoral experience is preferred. A small shared zebrafish facility will be available, complete with microinjection equipment, if needed.. Founded in 1885, Rollins is an independent, comprehensive, liberal arts college. The campus, noted for its lakefront beauty and for its unique location, is set in the residential community of Winter Park, just 15 minutes from one of the nations most dynamic urban centers, ...
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Professor Christiana Ruhrberg is an internationally known expert in neuronal and vascular development and one of the worlds leading researchers in defining mechanisms of blood vessel growth in the brain and eye. Her three main interests are neurovascular co-patterning, molecular regulation of angiogenesis, and signal transduction in vascular hyperpermeability.. She conducted her PhD with Fiona Watt on epidermal barrier function and was named Young Cell Biologist of the Year 1996 by the British Society for Cell Biology. Professor Ruhrberg carried out postdoctoral training with Robb Krumlauf on motor neuron development and with David Shima on blood vessel growth. In 2003, she received the Werner-Risau-Prize for outstanding contributions to endothelial cell biology from the German Society for Cell Biology and an MRC Career Development Award to study neurovascular co-patterning. She currently holds a Wellcome Trust Investigator Award to investigate neurovascular interactions in the brain and ...
By the time scientists arrive in San Diego in December 2015, an estimated 40,000 papers on cell biology will have been published since the 2014 meeting. Even more data will be available on imaging, protein structures, genomics, gene expression, and more. Our challenge is to convert this information into meaningful knowledge to understand how cells work. The 2015 ASCB meeting overarching theme is about making connections at different scales, from the intracellular level to the tissue level, to the organism level all the way up to the macrocosmic level, all in the light of big data and information integration. This integration will help us ask the right questions and find answers to the challenging problems in medicine, living systems, and ecosystems. Cell biology is increasingly relevant not only to those who think of themselves as cell biologists but also to more specialized researchers in neuroscience, immunology, cancer biology, synthetic biology, biophysics, molecular medicine, and more. ... ...
Mark. R. Philips, MD is Professor of Medicine, Cell Biology and Biochemistry & Molecular Pharmacology, and Associate Director for Basic Science at the NYU Cancer Institute; and Director of the Medical Scientist Training (MD/PhD) Program at the New York University School of Medicine.. Mark Philips is a molecular cell biologist who focuses on the post-translational modification and membrane targeting of small GTPases, especially Ras. His discovery in 1999 that Ras proteins are modified on, and traffic through, internal membranes en route to the plasma membrane had a major impact in the field. He went on to show that Ras can signal from internal membranes and made numerous contributions to our current understanding of Ras modification and trafficking. Current projects in his laboratory include efforts to characterize the effects of phosphorylation on Kras4B, differential trafficking of the two splice variants of Kras, novel cytosolic chaperones for Ras, as well as assay development for Kras ...
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Dr. Harris H. Wang is an Assistant Professor in the Department of Systems Biology, Pathology and Cell Biology at Columbia University, College of Physicians and Surgeons. Prior to joining Columbia, Dr. Wang was a Fellow at the Wyss Institute for Biologically Inspired Engineering and an Instructor in the Department of Systems Biology at Harvard Medical School. Dr. Wang holds B.S. degrees in Physics and in Mathematics from MIT and a Ph.D. in Biophysics from Harvard University. Dr. Wang has been developing foundational technologies in automated genome engineering to rapidly endow cells with improved function and new traits. In 2009, Dr. Wang won the Grand Prize in the National Inventor Hall of Fames Collegiate Inventors Competition. He is one of ten young investigators to receive the first NIH Directors Early Independence Award and was named in Forbes 30 under 30 in Science in 2012.. We are interested in understanding the key principles that drive the formation, maintenance, and evolution of ...
Associate Professor Kevin D. Brown earned his Ph.D. degree in Cell Biology at the University of Alabama-Birmingham in 1991 in the lab of Dr. Lester (Skip) Binder. He then joined Dr. Don Clevelands laboratory at Johns Hopkins where he worked on molecular mechanisms controlling chromosome migration and the cell cycle. In 1995 he joined Dan Tagles and Francis Collins group at the National Human Genome Research Institute/NIH where he began research on the function of the ATM kinase in the DNA damage response. In 1998 he took a position at LSU Health Sciences Center-New Orleans and rose to the rank of Associate Professor. He joined the Department of Biochemistry and Molecular Biology at UF in 2004. Dr. Brown has served on NIH and DOD study sections and as a reviewer for numerous journals in the field.. ...
In cell biology, as in love, you often dont know what youve got till its gone. For more than a century, scientists have known that most cells in the human body come equipped with an odd projection on their outer surfaces called the primary cilium. Unlike the wavy, hairlike cilia you may remember from biology class-the ones that sweep mucus out of the airways-the primary cilia are rigid and didnt seem to have any useful function. They were written off as vestigial, like tonsils or the appendix.. But 10 years ago, a handful of cell biologists including UABs Bradley Yoder, Ph.D., began to unravel the secrets of this obscure organelle. Starting in green algae and only lately moving up to humans, they made a startling discovery: If a cell loses its cilium, bad things begin to happen. Their investigations have revealed that, far from being an artifact, the primary cilium is actually an important communications device-and a major player in human growth and development, kidney disease, obesity, ...
George Emil Palade (19 Kasım 1912-8 Ekim 2008), Romanya doğumlu hücre biyoloğu. Şimdiye kadarki en etkili hücre biyoloğu olarak tanımlanır.[1] 1974 yılında Nobel Fizyoloji veya Tıp Ödülünü Albert Claude ve Christian de Duve ile birlikte kazanmıştır. Ödül kendisine elektron mikroskobu çalışmalarındaki yenilikleri ve hücre yapısıyla ilgili yaptığı çalışmalar sayesinde hücre biyolojisine getirdiği yenilikler nedeniyle verilmiştir.[1] En önemli keşifleri ilk kez 1955 yılında tanımladığı ribozomlar ve endoplazmik retikulum ile ilgili olanlardır.. ...
Committee on Development, Regeneration, and Stem Cell Biology at University of Chicago provides on-going educational opportunities to those students seeking advanced degrees.
This Saturday the ASCB 2016 meeting kicks off in San Francisco, and the city is already packed with excited cell biologists from all over the world. PLOS Biology isnt missing this annual date, and like every year, well be open to receive your best research in cell biology (submit now). If you have an exciting piece of research, Ill be very interested to hear about it, so please pass by the PLOS booth (# 229) and come to meet me in the Meet the editors session on Sunday 4 Dec or Tuesday 6 Dec from 1-2 pm. You can find below a taster of the papers that weve published in this field within the last year, and you can also visit the editors picks collection that PLOS has put together for you.. Looking forward to meeting you in San Francisco!. Featured image credit: Tamori Y, Suzuki E, Deng WM 2016. DOI: 10.1371/journal.pbio.1002537. Recently published papers:. Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy Dilay Hazal Ayhan, Yusuf Talha Tamer, Mohammed ...
Computational modeling can be used to investigate complex signaling networks in biology. However, most modeling tools are not suitable for molecular cell biologists with little background in mathematics. We have built a visual-based modeling tool for the investigation of dynamic networks. Here, we describe the development of computational models of cartilage development and osteoarthritis, in which a panel of relevant signaling pathways are integrated. In silico experiments give insight in the role of each of the pathway components and reveal which perturbations may deregulate the basal healthy state of cells and tissues. We used a previously developed computational modeling tool Analysis of Networks with Interactive Modeling (ANIMO) to generate an activity network integrating 7 signal transduction pathways resulting in a network containing over 50 nodes and 200 interactions. We performed in silico experiments to characterize molecular mechanisms of cell fate decisions. The model was used to ...
Staff profile for Dr Neil Hotchin of the School of Biosciences. Dr Hotchin is a molecular cell biologist with an interest in how cells interact with their immediate environment and how those interactions regulate functions such as cell proliferation, migration and differentiation.
MC: Tell us, if you would, a little about your background. I know you trained in Israel.. JK: Yes, I got my BSc, majoring in biology, at Tel Aviv University and then I was off to the Weizmann Institute of Science, which is a wonderful place to do research in Israel. I first worked in the laboratory of Moshe Oren, a very famous cell biologist, and then joined the lab of Michal Schwartz -who was a great mentor for many years- for my PhD, working on the role of the immune system reactions in CNS injuries. I stayed there for post-doctoral training, and then came to the US. I have been at UVA, the University of Virginia, since 2005 in the Department of Neuroscience, and Im a member of the Carter Immunology Center, combining my passions for immunology and neuroscience.. MC: So when you decided to go into immunology, were you immediately drawn to neuroimmunology, or did your interest in the brain and CNS come later?. JK: No, no-actually I trained in the Department of Neurobiology, so everyone around ...
This handwritten document consists of lecture notes of week 6 of course 5 discussing intracellular compartments and protein transport made so that you can just buy single notes to study for a specific lecture that you missed/need to focus on. Self-study notes related to this lecture is sold separately.
How does cellular stress affect lifespan? Does donating blood cause more cellular replication? Reducing lifespan?. Come listen to Prof. Emmanuelle Passegué from UCSF share her interesting research on blood stem cells and how they can age us.. Prof Passegué earned her PhD degree from the University Paris XI, France and then performed two consecutive postdoctoral fellowships. She first trained as a mouse geneticist with Dr. Erwin Wagner at the Institute for Molecular pathology (IMP) in Vienna, Austria, and then as a stem cell biologist with Dr. Irv Weissman at Stanford University. She joined the UCSF faculty in 2006, where she is currently a Professor in the Department of Medicine, Division of Hematology Oncology with the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research.. The Passegué labs research focuses on understanding the general defense mechanisms used by hematopoietic (blood) stem cells (HSC) to protect blood production during the lifetime of an ever-changing ...
An integrated lecture-lab experience introducing fundamental concepts and techniques in cell biology. Topics include cell structure, the cell cycle, apoptosis, stem cells, cell signaling, and cancer. Techniques include light and fluorescence microscopy. Prerequisites: BIO 110 and BIO 111. Spring, Fall.. ...
As a community journal, Journal of Cell Science is particularly keen to support the next generation of cell biologists. Here, we present two series of interviews; Cell Scientists To Watch, with talented researchers who have recently set up their own labs, and First Person, with the early-career first authors of a selection of papers published in Journal of Cell Science. These researchers talk about their lives in and out of the lab and the journeys that led them to where they are now. They also discuss the current state of science funding, the established researchers give advice on how to navigate the transition to independence and the early-career scientists reflect on advice they would give to PhD students at the start of their journey. Read the Cell Scientists To Watch interviews below and click here to jump to the First Person interviews. Know someone you think we should interview for Cell Scientists To Watch? Email us ...
Fluorescence microscopy is the primary tool for studying complex processes inside individual living cells. Technical advances in both molecular biology and microscopy have made it possible to image cells from many genetic and environmental backgrounds. These images contain a vast amount of information, which is often hidden behind various sources of noise, convoluted with other information and stochastic in nature. Accessing the desired biological information therefore requires new tools of computational image analysis and modeling. Here, we review some of the recent advances in computational analysis of images obtained from fluorescence microscopy, focusing on bacterial systems. We emphasize techniques that are readily available to molecular and cell biologists but also point out examples where problem-specific image analyses are necessary. Thus, image analysis is not only a toolkit to be applied to new images but also an integral part of the design and implementation of a microscopy experiment. ...
( -- In basic research with far-reaching impact, cell biologists Wei-Lih Lee and Steven Markus report in an article released today in Developmental Cell, with videos, that they have solved one of the fundamental ...
The focus of our lab is on cancer drug discovery using fragment-based approaches and structure-based design. To accomplish this goal, we have assembled a multidisciplinary team that includes structural biologists, medicinal chemists, and cell biologists. Among them are five research professors and several research assistants, postdoctoral fellows, and graduate students. In our lab, we clone, express, and purify proteins, conduct fragment-based screens, determine the three-dimensional structures of protein/ligand complexes using NMR and/or X-ray crystallography, design and synthesize compounds, and test compounds in primary and secondary biological assays. The cancer drug targets that we are pursuing are highly validated but technically challenging such as K-Ras and c-Myc ...
Dr. Deitz is a molecular biologist with diverse experience in the fields of cell biology, biochemistry, viral immunology, and vaccinology and is a co-founder of Synterica. Dr. Deitz earned his PhD in the field of yeast cell biology at the University of Colorado Health Sciences Center (now called the Anschutz Medical Campus). As a post-doctoral fellow at Stanford University, he applied his cell biology background to questions of virus-host interactions and how they pertain to the immune system. Dr. Deitz first entered the industrial arena as a vaccine development scientist. He has been responsible for the design and development of new vaccine candidates that utilize platforms ranging from replication-deficient viruses to naked DNA. He is proficient in the design, assembly, and selection of synthetic genes. In addition to his technical expertise, Dr. Deitz has experience in both project management and comprehensive study design. Dr. Deitz is co-founder of the joint-venture parent company, ...
Joshua LaBaer is one of the nations foremost investigators in the rapidly expanding field of personalized medicine. His efforts involve the discovery and validation of biomarkers - unique molecular fingerprints of disease - which can provide early warning for those at risk of major illnesses, including cancer and diabetes.. The Virginia G. Piper Center for Personalized Diagnostics (VGPCPD) has a highly multidisciplinary staff of molecular biologists, cell biologists, biochemists, software engineers, database specialists, bioinformaticists, biostatisticians, and automation engineers with individuals ranging from Ph.D. and M.D. degrees to graduate students to technical support individuals. An organizing principle of VGPCPD is the application of open reading frame clones to the high throughput (HT) study of protein function. Dr. LaBaer was an early initiator and leader of the effort to build fully sequence-verified recombination-based clone sets for human genes and other model organisms now ...
When neurons started dying in Clive Svendsens lab dishes, he couldnt have been more pleased.. The dying cells the same type lost in patients with the devastating neurological disease spinal muscular atrophy confirmed that the University of Wisconsin-Madison stem cell biologist had recreated the hallmarks of a genetic disorder in the lab, using stem cells derived from a patient. By allowing scientists the unparalleled opportunity to watch the course of a disease unfold in a lab dish, the work marks an enormous step forward in being able to study and develop new therapies for genetic diseases.. As reported this week in the journal Nature, Svendsen and colleagues at UW-Madison and the University of Missouri-Columbia created disease-specific stem cells by genetically reprogramming skin cells from a patient with spinal muscular atrophy, or SMA. In this inherited disease, the most common genetic cause of infant mortality, a mutation leads to the death of the nerves that control skeletal ...
The Kron laboratory is a diverse and collaborative group of cell biologists, geneticists, biochemists, chemists and computer scientists. Our current basic research and technology efforts include 1) defining roles for chromatin dynamics and cell cycle regulation in DNA damage checkpoint response and cellular senescence, 2) dissecting cross-talk between metabolism and DNA damage response, 3) developing novel molecular assays to interrogate cell signaling in cancer, and 4) implementing novel mass spectrometry approaches to enable quantitative proteomics. We also pursue translational projects directed at 1) discovering inhibitors of cellular response to DNA double strand breaks as an approach to radiosensitization, 2) examining DNA damage and repair in tissues and tumors, and 3) exploiting DNA damage responses to induce anti-tumor immune responses.. ...
Two UCSF scientists - brain researcher Michael Brainard, PhD, and cell biologist Dyche Mullins, PhD - have been selected to be Howard Hughes Medical Institute investigators.
Many areas of biological research increasingly perform large-scale analyses. In genomics the entire gene repertoire of an organism is analyzed. Proteomics attempts to understand the function and expression patterns of all proteins in a cell or organism. Cell biologists study large numbers of single cells to understand the heterogeneity of cell populations. In biotechnology and synthetic biology researchers search for new functional biomolecules in large libraries of biomolecular diversity e.g. for uses in medicine or bioprocessing. More and more all of these fields employ high throughput methods to achieve the scale of analysis necessary.. Miniaturization and parallelization provide routes towards high throughput analysis, which have proven successful for microelectronics as well as for DNA sequencing. For the analysis of cells and biomolecules, native to an aqueous environment, miniaturization and parallelization hinges on the handling and parallel processing of very small amounts of water. ...
Photo: Salahudeen, A. A. Shuibing Chen spent close to two months tending to her mini lungs — some half a million of them. Each one looked like a tiny storm cloud, ensconced in a warm dish and protected by a jelly-like dome. Chen, a stem-cell biologist at Weill Cornell Medicine in New York City, and her team had nurtured them from clumps of human cells, adding nutrients every few days as they grew into 3D air sacs. These lung organoids matured until they reached the size of a lentil. Then, the team packed them up and transported them just a few blocks away, to a laboratory authorized to work with SARS-CoV-2, the virus responsible for the COVID-19 pandemic. There, the organoids were drowned in virus and each was doused with one of 15,000 drugs. Almost all of the mini lungs died, but a few of the drugs stemmed from the infection — representing a handful of possible treatments for COVID-19. Chen is one of many cell biologists who have been driven by the pandemic to push the boundaries
Engineers, design architects and cell biologists from the University of Pennsylvania will use a National Science Foundation grant to utilize the flexibility and sensitivity of human cells as the models for next-generation building
Alternative Health and Wellness Interview, In recent columns, I have presented the evidence that vitamin E and other antioxidant nutrients are protective against heart disease. People -- especially scientists -- have trouble understanding this fact until they know how vitamin E accomplishes this feat. One scientist -- a cell biologist and biochemist -- has done much to establish the necessary cellular evidence elucidating the protective mechanism. Dr. David Janero is a member of the senior staff in the Cardiovascular- Atherosclerosis Research Department of CIBA-GEIGY Corporation, Pharmaceuticals Division.
Prof. marrison also saved the arm of a Port Arthur massacre survivor, Linda wanders. A bullet blew a 12cm whole through the womans right forearm, taking with it bone, a radial artery tendons nerves and muscle everything from the elbow to the wrist. Prof. Marrison and his team painstalingly rebuilt the womans arm in 16 operation offer three years, using bone from her keg, transplanted blood vessels, muscles and skin. Engineering research by prof. Morrison, 62 and his colleague at the Bernard institute of microsugery at st vunceits hospitals that could change millions of lives. The research had brought together molecular scaffold engineers, chemical engineers and stem cell biologists. Vital heart tissue can be grown using the techniques but scientists. Vital heart tissue can be grown using the technique but socialists at the institute have also grown muscles, tissue and fat the size of human first, with its own blood supply, inside a pig. The technology could one day be used for women who have ...
Running rodents make more of a Miracle-Gro chemical for the brain. A protein called brain-derived neurotrophic factor, or BDNF, has been labeled as the Miracle-Gro protein in the brain based on its role in enhancing memory and the growth of nerve cells. Researchers found in a study using mice that BDNF levels increase within the brain when the mice exercise on the wheel. We believe that our study shows a precise biological mechanism behind increased BDNF production in mammals due to exercise, says study senior investigator and cell biologist Moses Chao, PhD. Unraveling the mysteries of BDNF is important as we seek more ways to naturally keep mammalian brains healthy, including those or people, said Chao, a professor at NYU Langone and its Skirball Institute of Biomolecular Medicine. To read more, click here.. ...
To address these questions, we primarily study a eukaryotic model organism, the fission yeast Schizosaccharomyces pombe. These are simple rod-shaped cells that display a highly uniform size and rod-shape morphology. We seek to elucidate quantitative molecular and biomechanical mechanisms underlying the dynamic cellular processes responsible for morphogenesis of the cell. In our work, we use interdisciplinary approaches, combining the expertise and perspectives of cell biologists, geneticists, physicists, and engineers. We seek to develop new approaches to manipulate and assay processes in living cells, using microscopy, genetics, and micro-fabricated devices ...
Glioblastoma multiforme (GBM) is a devastating brain cancer for which there is no known cure. Its malignancy is due to rapid cell division along with high motility and invasiveness of cells into the brain tissue. Simple 2-dimensional laboratory assays (e.g., a scratch assay) commonly are used to measure the effects of various experimental perturbations, such as treatment with chemical inhibitors. Several mathematical models have been developed to aid the understanding of the motile behavior and proliferation of GBM cells. However, many are mathematically complicated, look at multiple interdependent phenomena, and/or use modeling software not freely available to the research community. These attributes make the adoption of models and simulations of even simple 2-dimensional cell behavior an uncommon practice by cancer cell biologists. Herein, we developed an accurate, yet simple, rule-based modeling framework to describe the in vitro behavior of GBM cells that are stimulated by the L1CAM protein using
When Fuchs started working on skin-derived stem cells during the fields nascency in 1978, the cells went by a different name.. Human epidermal keratinocytes. A very boring name, she said. We now, of course, know that virtually every tissue of our body has long-lived stem cells that are able to regenerate tissue, both to repair dying cells and also to repair wounds, so its virtually a universal property of the tissues of our body. But back then, there was very little known about it.. At that time, Fuchs was a postdoctoral fellow at the Massachusetts Institute of Technology in the lab of Howard Green, a cell biologist who pioneered skin grafting by growing human cells in culture. When Fuchs was a graduate student at Princeton working on bacterial sporulation, she had attended a guest seminar by Green about culturing cells from human skin.. I just immediately thought, Thats what I want to work on for my postdoctoral work, Fuchs said. It was at the time where a few people were starting ...
ART medical treatment still the only treatment available since we still dont have a vaccine for HIV- The treatment reduces the level of the virus in the patient so they no longer have AIDS- Aquired Immune Deficiency Syndrome and/or cannot transmit infection to partners.. * Note: I have already briefly mention these 2 procedures in my introduction**. One way to study the process of penetration of the host cell by the virus is to use time lapse cine photo microscopy When I was invited by Dr. P. Thorlakson of the Winnipeg Clinic in 1965 to set up at their Clinic a private research Laboratory we purchased a Sage time lapse photo microscopic apparatus to study the cell behaviour of human cells grown in tissue culture. I was familiar with blastogenesis- the process of cell division following the addition of phytoaggultin to the blood culture .-the procedure that cytogeneticist use to perform chromosomal analysis.- indeed I was the first cell biologist in Winnipeg to establish a private cytogenetic ...
The Infusoria or Ciliophora, as they are now called have long been recognized as a monophyletic assemblages. The composition of the group has remained largely unchanged since Faure-Fremiet (1950) included among holotrich ciliates, the suctorians, which had often not been included with the other ciliates by the specialists of the day (Corliss 1979). The classification of the group remained largely unchanged in the 20th century after Corliss (1961) formalized Faure-Fremiets conceptual vision, based primarily on the morphostatic morphology of the cells, derived from observation of the silver-stained ciliate cortex, and coupled with ontogenetic characters revealed through observation of division morphogenesis, and particularly stomatogenesis. Electron microscopy was just beginning as Corliss (1961) went to press. In the ensuing decades exploration of this new level of organization revealed a wealth of new characters for both cell biologists and systematists. These new data, accompanied by new ...
A physician and cell biologist who won a 1972 Nobel Prize for his work describing the structure of antibodies, Edelman is now obsessed with the enigma of human consciousness-except that he does not see it as an enigma. In Edelmans grand theory of the mind, consciousness is a biological phenomenon and the brain develops through a process similar to natural selection. Neurons proliferate and form connections in infancy; then experience weeds out the useless from the useful, molding the adult brain in sync with its environment. Edelman first put this model on paper in the Zurich airport in 1977 as he was killing time waiting for a flight. Since then he has written eight books on the subject, the most recent being Second Nature: Brain Science and Human Knowledge. He is chairman of neurobiology at the Scripps Research Institute in San Diego and the founder and director of the Neurosciences Institute, a research center in La Jolla, California, dedicated to unconventional high risk, high payoff ...
Individual muscles tend to be a mixture of various fiber types, but their proportions vary depending on the actions of that muscle and the species. For instance, in humans, the quadriceps muscles contain ~52% type I fibers, while the soleus is ~80% type I.[29] The orbicularis oculi muscle of the eye is only ~15% type I.[29] Motor units within the muscle, however, have minimal variation between the fibers of that unit. It is this fact that makes the size principal of motor unit recruitment viable. The total number of skeletal muscle fibers has traditionally been thought not to change. It is believed there are no sex or age differences in fiber distribution; however, proportions of fiber types vary considerably from muscle to muscle and person to person. Sedentary men and women (as well as young children) have 45% type II and 55% type I fibers.[citation needed] People at the higher end of any sport tend to demonstrate patterns of fiber distribution e.g. endurance athletes show a higher level of ...
Idiopathic pulmonary fibrosis, scleroderma and liver cirrhosis are just a few of a pantheon of confusingly named, difficult-to-treat and sometimes life-threatening diseases caused by the malfunction of a single cell type. But until now its not been clear whether the disorders shared a deeper root cause.. Now Stanford pathologist Gerlinde Wernig, MD, and stem cell biologist Irving Weissman, MD, have identified a cell signaling pathway that, when mutated, causes widespread fibrosis in laboratory mice. Whats more, they showed that an antibody currently in trials as an anti-cancer treatment can reverse the condition. They published their results this week in the Proceedings of the National Academies of Science.. From our release:. ...
So I had the pleasure of meeting the awesome Dr. Isis a few weeks ago. It turns out she is even more awesome in person than she is in pseudonymity. And she brought me a fabulous thing: a scarf from A Slice of Life Scarves. Creator Eve Reaven, a Bay Area cell biologist, has continuously marveled at the intricacy and beauty of the natural patterns found inside cells. She shares what she has seen with others through designs for scarves and other textiles. In the current selection, she captures the essence of structures related to cell movement, cell traffic, energy and performance. Many of the cell structures represented in these patterns are magnified 50,000 to 1,000,000 times their original size, allowing us to experience the amazing designs created by nature. It doesnt really sound that attractive - honestly, when I think of microtomes, I always think of a horrifically bloody accident I saw as an undergrad - but the patterns are gorgeous. I was wearing gray (which is very big this year), so I ...
Biology portal Science portal The American Society for Cell Biology Cell biophysics Cell disruption Cell physiology Cellular ... Cell biology is the study of structural and functional units of cells. Cell biology encompasses both prokaryotic and eukaryotic ... Wikibooks has more on the topic of: Cell biology Cell Biology at Curlie Aging Cell "Francis Harry Compton Crick (1916-2004)" by ... Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of ...
In mammals, major cell types include skin cells, muscle cells, neurons, blood cells, fibroblasts, stem cells, and others. Cell ... Cells Alive! Cell Biology in "The Biology Project" of University of Arizona. Centre of the Cell online The Image & Video ... Biology portal Cell cortex Cell culture Cellular model Cytorrhysis Cytoneme Cytotoxicity Human cell Lipid raft Outline of cell ... Some eukaryotic cells (plant cells and fungal cells) also have a cell wall. Inside the cell is the cytoplasmic region that ...
In cell biology, ways in which fragmentation is useful for a cell: DNA cloning and apoptosis. DNA cloning is important in ... "The Role of DNA Fragmentation in Apoptosis." Trends in Cell Biology 5.1 (1995): 21-26. Print. Bessman, JD. "Red Blood Cell ... Molecular Cell Biology. 7th ed. New York: W.H. Freeman and, 2013. Print. Bortner, Carl D., Nicklas B.E. Oldenburg, and John A. ... Molecular Cell Biology. 7th ed. New York: W.H. Freeman and, 2013. Print. Hua, Xhang J., and Ming Xu. "DNA Fragmentation in ...
Plant callus (plural calluses or calli) is a growing mass of unorganized plant parenchyma cells. In living plants, callus cells ... Regeneration of a whole plant that has some genetically transformed cells and some untransformed cells yields a chimera. In ... In Jatropha curcas callus cells, small organized callus cells became disorganized and varied in size after browning occurred. ... not individual cells.[clarification needed] Nevertheless, callus cells are often considered similar enough for standard ...
Articles lacking sources from December 2009, All articles lacking sources, Biochemistry, Cell biology). ... Biological cells which form bonds with a substrate and are at the same time subject to a flow can form long thin membrane ... cylinders called tethers, which connect the adherent area to the main body of the cell. Under physiological conditions, ...
In cell biology, a bleb is a bulge of the plasma membrane of a cell, characterized by a spherical, bulky morphology. It is ... Paluch, Ewa K; Raz, Erez (2013-10-01). "The role and regulation of blebs in cell migration". Current Opinion in Cell Biology. ... Paluch, Ewa K; Raz, Erez (2013-10-01). "The role and regulation of blebs in cell migration". Current Opinion in Cell Biology. ... Blebs have been seen in cultured cells in certain stages of the cell cycle. These blebs are used for cell locomotion in ...
Cell biology, All stub articles, Cell biology stubs). ... They are found in nurse cells of the developing Drosophila ... Nuage are the hallmark of Drosophila melanogaster germline cells, which have an electron-dense perinuclear structure and can ...
v t e (AC with 0 elements, Cell anatomy, All stub articles, Cell biology stubs). ... It is clear, and protects as well as transports things within the cell. Moreover, large numbers of actin filaments frequently ... is the non-granulated outer part of a cell's cytoplasm, while endoplasm is its often granulated inner layer. ... occur in the ectoplasm, which form an elastic support for the cell membrane. It contains actin and myosin microfilaments. ...
In cell biology, a granule is a small particle. It can be any structure barely visible by light microscopy. The term is most ... Cell anatomy, All stub articles, Cell biology stubs). ... The granules of certain cells, such as natural killer cells, ... cell organelle of plant cell (the others-vacuole and nucleoplasm). It serves as small container of starch in plant cell. In ... Insulin granules are secretory granules, which can release their contents from the cell into the bloodstream. The beta cells in ...
Molecular and cellular biology journals, All stub articles, Molecular and cell biology journal stubs). ... Nature Cell Biology is a monthly peer-reviewed scientific journal published by Nature Portfolio. It was established in 1999. ... "Nature Cell Biology". 2021 Journal Citation Reports. Web of Science (Science ed.). Clarivate. 2022. Official website Portal: ... Biology v t e (Articles with short description, Short description is different from Wikidata, Monthly journals (infobox), ...
Mitosis Centrosome Centriole Chromosome v t e (Cell biology, Cell cycle, Mitosis, All stub articles, Cell cycle stubs). ... This allows the cell to divide properly with each daughter cell containing full replicas of chromosomes. In some cells, the ... ISBN 0-8053-7171-0. Lodish HF, Darnell DE (2008). Molecular Cell Biology (6th ed.). New York: W. H. Freeman and Company. pp. ... ISBN 978-0-7167-7601-7. Mitosis, Molecular Biology of the Cell, Albert et al 4th Edition. Ishihara, Keisuke, et al. "Physical ...
Articles with short description, Short description is different from Wikidata, Organelles, Molecular biology, Cell biology). ... Molecular Cell Biology. 2 (1): 72-75. doi:10.1038/35048077. PMID 11413469. S2CID 205011982. Mullins JM, McIntosh JR (September ... The Journal of Cell Biology. 94 (3): 654-661. doi:10.1083/jcb.94.3.654. PMC 2112229. PMID 7130277. Skop AR, Liu H, Yates J, ... This endosome is marked by MKLP1, and can persist for up to 48 hours once internalised into another cell. It is coated in Actin ...
Lamella, in cell biology, is also used to describe the leading edge of a motile cell, of which the lamellipodia is the most ... Cell biology, Photosynthesis, All stub articles, Cell biology stubs). ... Oxford Dictionary of Biochemistry and Molecular Biology, Oxford University Press[page needed] "The Cytoskeleton and Cell ... It is placed between the two primary cell walls of two plant cells and made up of intracellular matrix. The lamella comprises a ...
... is a peer-reviewed scientific journal published by Portland Press for the International Federation ... for Cell Biology. The journal was established in 1977 as Cell Biology International Reports (ISSN 0309-1651) and published by ... "Cell Biology International". 2010 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2011. Official ... It covers all aspects of cell biology. The journal is abstracted and indexed in: BIOBASE BIOSIS Chemical Abstracts Service ...
A septum in cell biology is the new cell wall that forms between two daughter cells as a result of cell division. In yeast, ... "The Cell Biology of Fission Yeast Septation". Microbiology and Molecular Biology Reviews. 80 (3): 779-91. doi:10.1128/MMBR. ... Lesage G, Bussey H (June 2006). "Cell wall assembly in Saccharomyces cerevisiae". Microbiology and Molecular Biology Reviews. ... Cabib E, Roh DH, Schmidt M, Crotti LB, Varma A (June 2001). "The yeast cell wall and septum as paradigms of cell growth and ...
... is an academic journal of the Australian and New Zealand Society for Immunology covering basic ... and was converted in 1987 to Immunology and Cell Biology, making it one of the oldest speciality immunology journals in ... Bradley, T. R.; Metcalf, D. (1966). "The growth of mouse bone marrow cells in vitro". {{cite journal}}: Cite journal requires , ... "Australian Journal of Experimental Biology and Medical Science" - via ...
"Cell Chemical Biology". Bibliographic information for Cell Chemical Biology. Library of Congress. January 2016. Official ... Cell Chemical Biology is a monthly, peer-reviewed, scientific journal published by Cell Press. The journal publishes research ... in chemical biology and studies at the interface of chemistry and biology. " ... Cell Press academic journals, Monthly journals, All stub articles, Biochemistry journal stubs). ...
... bone marrow cells. Most other cells cannot divide indefinitely as after a few cycles of cell division the cells stop expressing ... so they are technically a single clone of cells. However, during course of cell division, one of the cells can get mutated ... When ultimately many cells are produced by a single cell, clonal expansion is said to have taken place. A somewhat similar ... One of the most prominent usage is in describing a clone of B cells. The B cells in the body have two important phenotypes ( ...
... is a peer-reviewed scientific journal in the field of molecular histology and cell biology, ... "Editorial Board". Histochemistry and Cell Biology. Springer Science+Business Media. Retrieved 2012-12-22. Official website v t ... and evaluation of methods and probes that can be used in the entire area of histochemistry and cell biology. The journal is ... Histochemistry and Cell Biology. Springer Science+Business Media. Retrieved 2012-12-22. "Society for Histochemistry". ...
... is a peer-reviewed scientific journal by Elsevier BV. Trends in Cell Biology is abstracted and indexed ... "Trends in Cell Biology". MIAR: Information Matrix for the Analysis of Journals. University of Barcelona. Retrieved 2022-05-31 ... "Trends in Cell Biology". 2020 Journal Citation Reports. Web of Science (Science ed.). Clarivate Analytics. 2020. Official ...
Ira Mellman (July 9, 2001). "Cell biology's journal gets a new look". The Journal of Cell Biology. Rockefeller University Press ... "Functional correlation between cell adhesive properties and some cell surface proteins". The Journal of Cell Biology. Jcb. ... Ledbetter, M. C.; Porter, K. R. (October 1, 1963). "A "Microtubule" in Plant Cell Fine Structure". The Journal of Cell Biology ... and Discharge in the Pancreatic Exocrine Cell". The Journal of Cell Biology. 20 (3): 473-495. doi:10.1083/jcb.20.3.473. PMC ...
v t e (Cell biology, Cell anatomy, All stub articles, Cell biology stubs). ... The dyadic space is the name for the volume of cytoplasm between pairs (dyads) of areas where the cell membrane and an ... For example, the phenomenon of calcium-induced calcium release, when extracellular calcium enters the cell through ion channels ... of Dyadic Junctional Complexes between Sarcoplasmic Reticulum and Plasmalemma in Rabbit Left Ventricular Myocardial Cells". ...
Cell biology, All stub articles, Cell biology stubs). ... A nucleolar detention center (DC) is a region of the cell in ... Molecular Biology of the Cell. 24 (18): 2943-2953. doi:10.1091/mbc.E13-04-0223. ISSN 1939-4586. PMC 3771955. PMID 23904269. ... DCs are absent from cells under normal culture conditions, but form in response to specific environmental triggers. The ... Prasanth, Kannanganattu V. (2012-01-27). "Policing cells under stress: noncoding RNAs capture proteins in nucleolar detention ...
... is a peer-reviewed scientific journal in the field of cell biology, cell physiology, and molecular biology ... Biol Cell 97: 1-2== References == Osborne HB. (2005) What's new for Biology of the Cell in 2005? (Editorial) Biol Cell 97: 1-2[ ... Biology of the Cell. 109 (3): 113-114. doi:10.1111/boc.201770010. PMID 28248426. Biology of the Cell home page Société ... Cell Cycle and Cancer (2008), Microtubules, RNA regulation (2008), Microbiology and Cell Biology (2010), Cilia (2011), ...
... is a scientific journal published by Mary Ann Liebert, Inc., and covers topics related to DNA and cell ... DNA and Cell Biology. Retrieved 2016-06-12. (Articles with short description, Short description is different from Wikidata, ... DNA and Cell Biology is indexed in: Biochemistry & Biophysics Citation Index Biological Abstracts BIOSIS Previews Biotechnology ... Molecular medicine Cellular organelles Protein biosynthesis and degradation Cell-autonomous inflammation and host cell response ...
Cell biology - (formerly cytology) The study of cells. Cell division - The process of one parent cell separating into two or ... The following outline is provided as an overview of and topical guide to cell biology: Cell biology - A branch of biology that ... Meristemic cell - Undifferentiated plants cells analogous to animal stem cells. Stem cell - Undifferentiated cells found in ... A discipline bridging microbiology and cell biology. Biology portal Outline of biology Young John K Introduction to Cell ...
... is a bi-monthly, peer-reviewed scientific journal of biochemistry and cell biology established in ... was renamed Canadian Journal of Biochemistry and Cell Biology and acquired its current name Biochemistry and Cell Biology in ... Molecular and cellular biology journals, Canadian Science Publishing academic journals, English-language journals, Bimonthly ... with the Canadian Society for Molecular Biosciences and the Panamerican Association for Biochemistry and Molecular Biology. ...
Cell biology Molecular biology Journal of Cell and Molecular Biology Institute of Molecular and Cell Biology (disambiguation) ... Biology Max Planck Institute of Molecular Cell Biology and Genetics Molecular Biology of the Cell Molecular Biology of the Cell ... Cell and Molecular Biology Test International Review of Cell and Molecular Biology American Journal of Respiratory Cell and ... Cell and molecular biology are related fields of biology that are often combined. ...
"Cell Biology". "Displaying Record for Publication: Nature Reviews Molecular Cell Biology". CASSI. Chemical Abstracts Service. ... Nature Reviews Molecular Cell Biology is a monthly peer-reviewed review journal published by Nature Portfolio. It was ... "Journals Ranked by Impact: Cell Biology". 2021 Journal Citation Reports. Web of Science (Science ed.). Clarivate. 2022. ... established in October 2000 and covers all aspects of molecular and cell biology. The editor-in-chief is Kim Baumann. According ...
... in Cell Biology is a bimonthly peer-reviewed scientific journal published by Elsevier covering all aspects of cell biology ... Molecular and cellular biology journals, Elsevier academic journals, All stub articles, Molecular and cell biology journal ... "Current Opinion in Cell Biology". Elsevier. Retrieved 30 September 2019. "InCites Journal Citation Reports". Clarivate ... including genetics, cell communication, and metabolism. It was established in 1998 and is part of the Elsevier Current Opinion ...
Williams, Ruth (2008-06-30). "Paul Mischel: All about brains". The Journal of Cell Biology. 181 (7): 1044-1045. doi:10.1083/jcb ... 2007 Profiled by Journal of Cell Biology in the "People and Ideas" section, 2008 President, American Society for Clinical ... Zimmer, Carl (2019-11-20). "Scientists Are Just Beginning to Understand Mysterious DNA Circles Common in Cancer Cells". The New ... Molecular Cell. 67 (1): 128-138.e7. doi:10.1016/j.molcel.2017.05.030. ISSN 1097-4164. PMC 5521991. PMID 28648777. Guo, Deliang ...
Contraction of heart muscle cells requires depolarization and repolarization of their cell membranes. Movement of ions across ... Campbell, N., & Reece, J. (2002). Biology. 6th ed. San Francisco: Benjamin Cummings[page needed][ISBN missing] Gray, Huon H.; ... Bone morphogenetic protein (BMP) cell signaling plays a key role in diverse aspects of cardiac differentiation and ... and Evolutionary Biology. 280 (2): 934-939. doi:10.1002/ar.a.20099. PMID 15372490. "Dual Atrioventricular Nodal Physiology - an ...
Cell. 164 (1-2): 29-44. doi:10.1016/j.cell.2015.12.035. PMID 26771484. Westra ER, Dowling AJ, Broniewski JM, van Houte S ( ... Wright AV, Nuñez JK, Doudna JA (January 2016). "Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for ... CRISPR-Cas3 destroys the targeted DNA in either prokaryotic or eukaryotic cells. Co-founder, Rodolphe Barrangou, said "Cas3 is ... Molecular Biology. 21 (9): 771-7. doi:10.1038/nsmb.2875. PMC 4156918. PMID 25132177. Gasiunas G, Barrangou R, Horvath P, ...
It is known that the most frequently colonized sites are epithelial cell surfaces and red and white blood cells inside of the ... 36(5): 1371-1377 Razin, Shmuel, Yogev, David and Naot, Yehudith (1998) Molecular Biology and Pathogenicity of Mycoplasmas ... Since M. incognitus is a mycoplasma, it does not have a cell wall, which means that it is naturally immune to many different ... This mycoplasma acts by entering into the individual cells of the body where it can lie dormant for 10, 20, or 30 years. If the ...
... the geographical reference is the location and/or the coverage area of the network cell (initially the ID of the cell). For ... PLOS Computational Biology. 10 (7): e1003716. arXiv:1309.7272. Bibcode:2014PLSCB..10E3716T. doi:10.1371/journal.pcbi.1003716. ... The accuracy of passive mobile positioning is limited to the coverage area of network cells, which can range from a few hundred ... Moreover, the accuracy of passive mobile positioning is limited to the coverage area of network cells, which can range from a ...
Cell. 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923. ... Advances in Experimental Medicine and Biology. Vol. 253A. pp. 511-8. doi:10.1007/978-1-4684-5673-8_83. ISBN 978-1-4684-5675-2. ... Progress in Nucleic Acid Research and Molecular Biology. Vol. 53. pp. 1-78. doi:10.1016/s0079-6603(08)60142-7. ISBN ... Lin T, Suttle DP (May 1995). "UMP synthase activity expressed in deficient hamster cells by separate transferase and ...
It is a multidisciplinary research field at the intersection of virology, synthetic biology, computational biology, and DNA ... For many viruses, viral RNA is infectious when introduced into a cell (during infection or after reverse transcription). These ... as long as the information of their genome sequence is known and permissive cells are available. As of March 2020, the full- ... Synthetic biology, All stub articles, Virus stubs). ...
Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of ... BMC Evolutionary Biology. 8: 226. doi:10.1186/1471-2148-8-226. PMC 2533330. PMID 18673564. Soyer J, Flasse L, Raffelsberger W, ... It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the ... Developmental Biology. 351 (1): 135-45. doi:10.1016/j.ydbio.2010.12.043. PMC 3042741. PMID 21215266. This article incorporates ...
"CAR T Cells: Engineering Patients' Immune Cells to Treat Their Cancers". National Cancer Institute. 2013-12-06. Retrieved 9 ... Initial work was done by laboratories at the MRC Laboratory of Molecular Biology (Greg Winter and John McCafferty), the Scripps ... The phage gene and insert DNA hybrid is then inserted (a process known as "transduction") into E. coli bacterial cells such as ... These are made into synthetic receptors for T-Cells collected from the patient that are used to combat the disease. Competing ...
He wrote a PhD dissertation entitled, "On the Development of Parasitic Copepoda." 1907-1910: McClendon taught biology at ... life processes of cell membranes, the importance of pH control, the role of iodine in human health, and specifically its ...
Life sciences included experiments on human health, cell separation and biology, developmental biology, animal and human ... Test subjects included the crew, Japanese koi fish (carp), cultured animal and plant cells, chicken embryos, fruit flies, fungi ...
Molecular cell biology (4th ed.). New York: W. H. Freeman. ISBN 978-0-7167-3136-8. Morgan, David (2007). The Cell Cycle: ... but it changes the course of the cell. After a vertebrate cell has been in the G1 phase for about three hours, the cell enters ... After R and before S, the cell is known as being in G1-ps, or the pre S phase interval of the G1 phase. In order for the cell ... Within the cell cycle, there is a stringent set of regulations known as the cell cycle control system that controls the timing ...
Cell Dev. Biol. 17 (5): 544-54. doi:10.1016/j.semcdb.2006.09.001. PMID 17071117. Minghetti L, Pocchiari M (2007). " ... O'Banion MK (1999). "Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology". Crit Rev Neurobiol. 13 (1): 45-82. ... PTGS2 (COX-2) is unexpressed under normal conditions in most cells, but elevated levels are found during inflammation. PTGS1 ( ... Since PTGS2 (COX-2) is generally expressed only in cells where prostaglandins are upregulated (e.g., during inflammation), drug ...
Cell phones are also very common among all three groups today. Text messaging has made cell phones particularly useful for ... Human Biology. Vol. 66. JHU Press. pp. 411-20. ISBN 9780801870897. PMID 8026812. Colin Low. "The Hutterites by Colin Low - NFB ...
During 1994, he was a SERC/NATO funded research scientist in Department of Plant Biology at Stanford University. He has been ... The Plant Cell. 6 (5): 761-772. doi:10.1105/tpc.6.5.761. ISSN 1532-298X. PMC 160474. PMID 12244257. Graham, Ian A. (2008). " ... He was appointed a lecturer in the division of Biochemistry and Molecular Biology at University of Glasgow from 1994 to 1999. ... Additionally, Graham was elected as a member of the European Molecular Biology Organization (EMBO) in 2016,[citation needed] ...
Presence of 1,8-dihydroxynaphthalene melanin in the cell wall confers to the microfungi their characteristic olivaceous to dark ... Fungal Biology. 115 (10): 1077-91. doi:10.1016/j.funbio.2010.11.006. PMID 21944219. Onofri, S.; Barreca, D.; Selbmann, L.; ... Black yeasts share some distinctive characteristics, in particular a dark colouration (melanisation) of their cell wall. ... Morphological plasticity, incrustation of the cell wall with melanins and presence of other protective substances like ...
PBS Frontline Oct 22, 2013 Hunting the Nightmare Bacteria Portal: Biology (CS1 French-language sources (fr), CS1 Croatian- ... a class of beta-lactam antibiotics that are capable of killing most bacteria by inhibiting the synthesis of one of their cell ...
In medical research, the most famous immortalized cell line, known as HeLa, was developed from cervical cancer cells of a woman ... and Reproductive Biology. 121 (1): 99-103. doi:10.1016/j.ejogrb.2004.11.024. PMID 15949888. Jensen KE, Schmiedel S, Frederiksen ... carcinoma Small cell carcinoma Neuroendocrine tumour Glassy cell carcinoma Villoglandular adenocarcinoma Though squamous cell ... It is due to the abnormal growth of cells that have the ability to invade or spread to other parts of the body. Early on, ...
Within molecular and cell biology, HLA-DQ3 (DQ3) is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9. ... implications for studies assessing the role of human Ia molecules in cell interactions and disease susceptibility". Proc. Natl ...
... is biased to being expressed in androgen sensitive cells compared to androgen insensitive cells. A predicted 3' UTR ... "Phyre 2 Results for PANO1_phyre2". Retrieved 2021-08-01. "Genomatix Software Suite". Genomatix.{{cite web ... p14ARF is a protein that is a known tumor suppressor.It does this by controlling cell proliferation and cell survival, however ... With a confidence level of 5 out of 5, PANO1 has been theorized to be expressed in the nucleolus of the cell. PANO1 is an ...
Randy O. Wayne (15 September 2009). Plant Cell Biology: From Astronomy to Zoology. Academic Press. pp. 17-. ISBN 978-0-08- ... A Traube cell is an "artificial cell" created by Moritz Traube in order to study the processes of living cells, including ... The ability of the Traube cell membrane to allow water to flow in while retaining the cell solute is comparable to living cells ... The Traube cell is not a true artificial cell, as it is not living and does not have true biological processes of its own. ...
Lyn and Fgr are highly expressed in malignant prostate cells compared to normal prostate cells. When the primary prostate cells ... Portal: Biology (Articles with short description, Short description matches Wikidata, Genes on human chromosome 20, Webarchive ... HSP90 inhibitor NVP-BEP800 has been described to affect stability of Src tyrosine kinase and growth of T-cell and B-cell acute ... Src, Fyn and Yes are expressed ubiquitously in all cell types while the others are generally found in hematopoietic cells. c- ...
Seminars in Cell & Developmental Biology. 8 (5): 477-488. doi:10.1006/scdb.1997.0173. PMID 9441953. Retrieved 10 November 2017 ...
Molecular Cell. 11 (6): 1425-34. doi:10.1016/s1097-2765(03)00181-3. PMID 12820957. Urban S, Lee JR, Freeman M (October 2001). " ... Journal of Molecular Biology. 394 (5): 815-25. doi:10.1016/j.jmb.2009.10.025. PMID 19850051. This article incorporates text ... "Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it ... "Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases". Cell. 107 (2): 173-82. doi:10.1016/s0092- ...
Short, B. (2010). "Daniel Klionsky: A full plate for autophagy". The Journal of Cell Biology. 189 (1): 8-9. doi:10.1083/jcb. ... As a cell biologist, Klionsky pioneered the understanding of autophagy, the process by which cells break down to survive stress ... Although he enjoyed biology in high school, Klionsky enrolled at the University of California, Los Angeles while majoring in ... In 1997, he was named a full professor and accepted a Guggenheim Fellowship in the field of Molecular and Cellular Biology. ...
Nopcsa, F. (1933). "On the biology of the theromorphous reptile Euchambersia". Annals and Magazine of Natural History. 10. 12 ( ... or alternatively a ganglion of nerve cells. It is also possible that this organ functioned as a replacement for the parietal ... Biology. Bloomington: Indiana University Press. pp. 31-64. ISBN 978-0-253-00533-5. Rubidge, B.S.; Erwin, D.H.; Ramezani, J.; ... Journal of Experimental Biology. 207 (24): 4231-4238. doi:10.1242/jeb.01278. PMID 15531644. Benoit, J.; Abdala, F.; Manger, P.R ...
In developmental biology, choriogenesis is the formation of the chorion, an outer membrane of the placenta that eventually ... April 1993). "Induction of choriogenesis by 20-hydroxyecdysone in the German cockroach". Tissue & Cell. 25 (2): 195-204. doi: ... Developmental Biology. 160 (1): 28-38. doi:10.1006/dbio.1993.1283. PMID 8224544. Bellés X, Cassier P, Cerdá X, et al. ( ...
Coronaviruses manipulate the cell cycle of the host cell through various mechanisms. In several coronaviruses, including SARS- ... Masters, Paul S. (2006). "The Molecular Biology of Coronaviruses". Advances in Virus Research. 66: 193-292. doi:10.1016/S0065- ... N also has additional functions in manipulating the cell cycle of the host cell. The N protein is highly immunogenic and ... "Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals". Cell. 181 (7 ...
This has led to significant setbacks for the Soviet science, notably in biology due to ban on genetics (see "Lysenkoism") and ... accused the administration in July 2007 of political interference and muzzling him on key issues like embryonic stem cell ...
In biology, a sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and usually assumed to be ... For example, by aligning the amino acid sequences specified by the GCM (glial cells missing) gene in man, mouse and D. ... Biology portal Biomolecular structure Mammalian Motif Finder MochiView Multiple EM for Motif Elicitation Nucleic acid sequence ... PLOS Computational Biology. 1 (7): e67. Bibcode:2005PLSCB...1...67S. doi:10.1371/journal.pcbi.0010067. PMC 1309704. PMID ...
Nature Cell Biology (Nat Cell Biol) ISSN 1476-4679 (online) ISSN 1465-7392 (print) ... that simultaneously generated diacylglycerol and Ca2+ signals might stimulate cells synergistically (Kaibuchi, K. et al. Cell ... Chem. 257, 7847-7851; 1982). This discovery both fixed PKC at the heart of normal and pathological cell control and provided ... Nat Cell Biol 7, 17 (2005). ... Nature Cell Biology volume 7, page 17 (2005)Cite this article * ...
Cell Reports presents its cancer biology content in a collection updated on a weekly basis. ... This collection contains the list of the articles published in Cell Reports in the cancer biology field and is updated on a ...
... encouraging studies that shed light on the mechanisms underlying fundamental cell biological processes in physiology and ... Nature Cell Biology publishes research of the highest quality across all areas of cell biology, ... Nature Cell Biology (Nat Cell Biol) ISSN 1476-4679 (online) ISSN 1465-7392 (print) ... This month, we host a free, virtual Nature Conference with Nature Metabolism and Nature Reviews Molecular Cell Biology, ...
Professional Development Resources QB3-Berkeley Graduate and Postdoc Career Development Graduate Student Professional Development Guide MCB 295 Careers for Life Sciences PhDs Individual Development Plan (IDP) UC Berkeley Career Center MCB Industrial Affiliates Program
The cell reprogramming that occurs in hematopoietic cells is termed hematopoietic reprogramming. ... Classically, animal cells nucleate or form new microtubules off the perinuclear centrosome. In recent years, the Golgi outpost ... Cancer cell identity and plasticity are required in transition states, such as epithelial-mesenchymal transition (EMT) and ... discuss the hematopoietic cell dedifferentiation and transdifferentiation induced by diverse modulators. A comprehensive ...
Meet the primary faculty in Cell Biology, Neurobiology and Anatomy at the Medical College of Wisconsin. ... Stem cell-mediated tissue regeneration, human stem cell-based disease modeling, non-coding RNA and mitochondrial mechanisms in ... Comprehensive teaching in Clinical Human Anatomy, Cell and Tissue Biology and Integrated Medical Neuroscience ... Deciphering the interplay between transcription factors and chromatin dynamics in normal and malignant hematopoietic stem cells ...
... are found throughout the cytoplasm of all eukaryotic cells and perform a number of functions. ... BACK TO PLANT CELL STRUCTURE. Questions or comments? Send us an email.. © 1995-2022 by Michael W. Davidson and The Florida ... and participate in the formation of spindle fibers during cell division (mitosis). The length of microtubules in the cell ... In an animal cell, it is this end that is located at the centriole-containing centrosome found near the nucleus, while the plus ...
C. All cells have static organelles D. All cells have cell walls. E. All cells are attached to other cells. ... Some specialized cells such as neurons and red blood cells lose their ability to divide a maturity. Which phase of the cell ... Im stuck... Which of the following statements about cells is true? A. All cells are motile B. All cells have internal ... Some white blood cells are said to be amoeboid. How do you predict that these cells move? ...
Cell biology and developmental biology. Cell biology and developmental biology. .addthis_counter.addthis_bubble_style { width: ... Receive email alerts on new books, offers and news in Cell biology and developmental biology. ... Molecular Machines in Biology Workshop of the Cell. Frank, Joachim Published: March 2012Published: February 2012 ... The Cell as a Machine textbook Sheetz, Michael Yu, Hanry Published: January 2018Published: January 2018 ...
cell biology. * The undead can think? How dormant bacteria can still calculate their return to life. Core Sciences October 7, ... Spring cleaning cells take out the trash before they divide. Biology May 16, 2022 ...
"We saw things in live animals that you dont see in cell culture. The reasons, in this case, very well may be that the ... Elvis did it, Michael Jackson did it, and so do the mitochondria in our cells. They shake. While Elvis and Michael shook for ... They generate a continuous supply of the molecule ATP that, like bits of coal, serve as the cells main source of energy to ... To keep cells fully charged, mitochondria operate four biochemical production lines that coalesce with oxygen molecules from ...
Cell membranes are crucial to the life of the cell. The plasma membrane encloses the cell, defines its boundaries, and ... Molecular Biology of the Cell. 4th edition.. Show details. Alberts B, Johnson A, Lewis J, et al. ... Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002. Chapter 10, Membrane Structure. ... In all cells, the plasma membrane also contains proteins that act as sensors of external signals, allowing the cell to change ...
Cell, 59:1061-70, 1989. Thomas Sollner (University of Munich): The complex organization of eucaryotic cells into various ... Cell Biology T. Sollner, G. Griffiths, R. Pfaller, N. Pfanner, W. Neupert, MOM19, an import receptor for mitochondrial ... Cell Biology. Cell Biology T. Sollner, G. Griffiths, R. Pfaller, N. Pfanner, W. Neupert, "MOM19, an import receptor for ... Cell Biology. T. Sollner, G. Griffiths, R. Pfaller, N. Pfanner, W. Neupert, "MOM19, an import receptor for mitochondrial ...
The Cell Biology program aims to understand how cells function at the molecular level, and how these functions go awry in ... Cell-cell and cell-pathogen interactions (Cell-Cell/Cell-Host). This research involves the study of how cells are affected by ... Cell Biology Seminars. Cell Biology Seminars are held virtually via Zoom every Friday from 1:30 to 2:30 p.m. unless otherwise ... Developmental & Stem Cell Biology We focus on cutting-edge developmental genetics, genomics and stem cell biology research. ...
... which are the cells and tissue that generate sensation, perception, movement, learning, emotion, and many of the functions that ... Biology 1A/1AL. 5. Chem 3B/3BL. 5. Biology 1A/1AL. 5. ... Molecular and Cell Biology. *130 Cell and Systems Biology (Sp; ... All Neurobiology majors receive essential coursework in molecular and cell biology, as well as rigorous training in specific ... Psych C112 The Biology of Stress (no longer offered; 3 units). *MCB 167 Physiological and Genetic Basis of Behavior (Sp; 3 ...
in Professors Plants, Soil and Algae Developmental Biology Genomics Plant Biology /by Grant Alkin. ...
Theory of bubbles lifts cell biology into a new, more quantitative era Peer-Reviewed Publication Princeton University, ... Theory of bubbles lifts cell biology into a new, more quantitative era. Princeton University, Engineering School ... ... The new work marks a seismic shift in scientists ability to manipulate cells. Image courtesy of the researchers view more ...
Molecular Biology Graduate Programs . Review requirements for Cell & Molecular Biology degrees and accredited schools 2022 - ... What can you do with a PhD in cell and molecular biology?. There are various career paths for the cell and molecular biology ... What are Types of Cell and Molecular Biology Graduate Programs?. Molecular biology graduate programs offer students many ... in Cell Biology and Anatomy, or a Bioenergy Graduate Certificate program. A degree from a molecular biology graduate school ...
亚马逊 图书分类提供丰富的Cell Biology - Biology及其相关产品,天 ... Molecular Biology of the Cell: The Problems Book: for Molecular Biology of the Cell (English Edition) John Wilson ... The Lives of a Cell: Notes of a Biology Watcher (English Edition) Lewis Thomas ... AP® Biology Crash Course, For the New 2020 Exam, Book + Online: Get a Higher Score in Less Time (Advanced Placement (AP
epigenetics, stem cells, embryonic stem cell technology, stem cell therapy, transcription factors, in vitro differentiation, ... 7.349 Stem Cells: A Cure or Disease? , Biology Have you ever considered going to a pharmacy to order some new cardiomyocytes ( ... In this course, we will explore the underlying biology behind the idea of using stem cells to treat disease, specifically ... 7.342 Pluripotent Stem Cells and Genome Engineering for Modeling Human Diseases , Biology ...
Kannans Stem Cell and Cancer Biology Lab at Mayo Clinic. ... Explore professional and patient cancer and stem cell resources ... Kannan recommends exploring these professional and patient resources related to stem cells, cancer biology and breast cancer. ...
Cell & Molecular Biology students learn theories and techniques necessary to advance our understanding of diseases. ... The Cell & Molecular Biology curriculum focuses on courses in advanced cell biology, molecular genetics and biochemistry. ... Cell & Molecular Biology students learn experimentation and laboratory techniques used in cell biology, physiology, and ... The Pre-Medicine/Cell and Molecular Biology Emphasis requires a minimum of 67 credits, including the 26-credit Biology Nucleus ...
The UCL Research Department of Cell and Developmental Biology has a very active MPhil/PhD programme. ... The Department of Cell and Developmental Biology (CDB) has a very active MPhil/PhD programme. We currently have more than fifty ... Cell and Developmental Biology PhD Programme: available for three years in a single laboratory (or five years part-time) - see ... Developmental and Stem Cell Biology PhD Programme - Outline. This programme offers a unique environment with one of the largest ...
Purchase International Review of Cell and Molecular Biology, Volume 293 - 1st Edition. Print Book & E-Book. ISBN 9780123943040 ... International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both ... International Review of Cell and Molecular Biology. Holiday Sale. :. Save up to 25% on print and eBooks with FREE shipping. No ... Integration of intracellular symbionts into host cells leading to the acquisition of new cell components and cell variation; ...
Landmark Papers in Cell Biology Gall JG, McIntosh JR, eds. (online in The American Society for Cell Biologys Image & Video ... Models for Cell Biology Research *How do we know how cells function ... Cell Biology. From Wikibooks, open books for an open world. The latest reviewed version was checked on 27 May 2020. There are ... Retrieved from "" ...
... whose goal is to foster and support cutting-edge basic and translational research into the biology and physiology of lung cells ... innate and adaptive immune cells, and the signaling pathways that regulate their function. ... Learn about the Division of Cell Biology, which is an interdepartmental program ... cell biology, immunology, development, remodeling, repair and lipid mediator biology. These specialties have translational ...
Genetics and Cell Biology Genetics and Cell Biology is the home of basic, clinical and diagnostic research spanning from the ... Genetics and Cell Biology contributes to research activities of four out of five FHML research schools and aims to meet the ... Genetics and Cell Biology. *Inflammation and lipid signaling for novel diagnosis and treatment of metabolic diseases ... The combination of genetic and cell biological approaches allows for synergy in functional understanding of genetic variations ...
Riotton, Gustave Louis Jules; Christopherson, William M; Lunt, Ramona; World Health Organization (‎Organisation mondiale de la Santé, 1973)‎ ...
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... such as the cell, through the integration of many different types of information. Here, we discuss how the incorporation of ... Systems biology seeks to explain complex biological systems, ... Structure-based systems biology: a zoom lens for the cell FEBS ... Systems biology seeks to explain complex biological systems, such as the cell, through the integration of many different types ... We suggest a process of zooming on the cell, from global networks through pathways to the precise atomic contacts at the ...
  • Kwang Jeon received his Ph.D. in cell physiology at King's College, University of London, UK, in 1964 and taught at SUNY Buffalo and University of Tennessee. (
  • Its mission is to foster and support cutting-edge basic and translational research into the biology and physiology of lung cells, innate and adaptive immune cells, and the signaling pathways that regulate their function. (
  • The Department of Anatomy, Cell Biology and Physiology offers a selection of courses at the Indianapolis campus that are open to all Indiana University graduate students. (
  • The Cell & Molecular Biology curriculum focuses on courses in advanced cell biology, molecular genetics and biochemistry. (
  • Genetics and Cell Biology is the home of basic, clinical and diagnostic research spanning from the molecular, cellular and organ level to individuals, families and the population. (
  • Genetics and Cell Biology contributes to research activities of four out of five FHML research schools and aims to meet the recommendations of the 'Gezond Leven' strategic research report with a strong visible focus on health and prevention. (
  • These studies use genetics, biochemistry, omics and cell biology with an emphasis on advanced imaging by fluorescence and electron microscopy of the infected cell. (
  • Our curriculum follows national guidelines from our professional organization, the American Society for Biochemistry and Molecular Biology (ASBMB). (
  • Receive email alerts on new books, offers and news in Cell biology and developmental biology. (
  • The Department of Cell and Developmental Biology (CDB) has a very active MPhil/PhD programme. (
  • Select "Division of Biosciences" for the UCL Department you are applying to and "Research Degree: Cell and Developmental Biology" for Programme Title. (
  • This programme offers a unique environment with one of the largest and strongest concentrations of high quality developmental and stem cell biologists anywhere in the world. (
  • The programme provides training at the interface between developmental and stem cell biology. (
  • The MCB PhD program at Brandeis provides supportive and close-knit community conducting internationally recognized research at the frontiers of molecular, cell, developmental, chemical and neurobiology. (
  • Cell and Developmental Biology offers opportunities for Masters , MD/Ph.D. , and Ph.D. programs. (
  • After rotations, students joining a research laboratory in CDB will officially enter the Cell and Developmental Biology Program. (
  • A team led by Magdalena Götz , Head of LMU Department of Physiological Genomics and Director of the Institute for Stem Cell Research (ISF) at Helmholtz Munich, now evaluated this notion in neurons and their developmental precursors, so-called neuronal stem cells. (
  • Seminars in Cell & Developmental Biology, 77,144-152. (
  • Ion gradients across membranes, established by the activities of specialized membrane proteins, can be used to synthesize ATP, to drive the transmembrane movement of selected solutes, or, in nerve and muscle cells, to produce and transmit electrical signals. (
  • In the plasma membrane, some proteins serve as structural links that connect the cytoskeleton through the lipid bilayer to either the extracellular matrix or an adjacent cell, while others serve as receptors to detect and transduce chemical signals in the cell's environment. (
  • As would be expected, it takes many different membrane proteins to enable a cell to function and interact with its environment. (
  • Thomas Sollner (University of Munich): "The complex organization of eucaryotic cells into various membrane-bound compartments (organelles) requires a very specific targeting of newly synthesized proteins to their final destinations. (
  • The current work follows Brangwynne's discovery more than a decade ago that cellular proteins organize into liquid structures inside the cell. (
  • We suggest a process of zooming on the cell, from global networks through pathways to the precise atomic contacts at the interfaces of interacting proteins. (
  • In close collaboration with the Helmholtz Munich Proteomic Core Facility led by Stefanie Hauck, the researchers found that the composition of proteins in centrosomes differs profoundly depending on the cell type. (
  • Genes 'tell' cells to make proteins. (
  • Understand: genes, proteins, and cells Get 3 of 4 questions to level up! (
  • Learn about cell specialization, genes and proteins, and the organization of multicellular organisms. (
  • Most bacteria are, however, surrounded by a rigid cell wall made out of peptidoglycan , a polymer composed of linked carbohydrates and small proteins. (
  • For instance, although archaea also have a cell wall, it's not made out of peptidoglycan-although it does contain carbohydrates and proteins. (
  • It acts as an anchor, connecting each muscle cell's structural framework (cytoskeleton) with the lattice of proteins and other molecules outside the cell (extracellular matrix). (
  • In this collection, we highlight recent papers published across Nature Portfolio journals on topics including embryonic development and stem cells, clinical and translational research, stem cell-based tissue engineering, and tissue stem cells. (
  • Hematopoiesis generally refers to hematopoietic development in fetuses and adults, as well as to hematopoietic stem cell differentiation into progeny lineages. (
  • It might sound crazy, but recent developments in stem cell science have made this concept not so futuristic. (
  • She is a physician-scientist specializing in clinical breast radiation oncology with a lab focused on inflammatory breast cancer, the microenvironment and breast cancer stem cell biology. (
  • The insights into these processes have been instructive for all stem cell biology, and are crucial for understanding fertility and managing reproductive disorders. (
  • The expansion of knowledge in the germline stem cell field is rapid and it is important that key developments are shared in a timely manner among the community members. (
  • View cart "Pristine Bio Cellulose Stem Cell Mask (3pcs)" has been added to your cart. (
  • Pristine Bio Cellulose Stem Cell Mask contains EGF, which is a collagen and elastin stimulator improves skin laxity and reduces the wrinkles and fine lines on your skin. (
  • Besides that, Pristine Bio Cellulose Stem Cell Mask contains high percentage of Hyaluronic Acid, which helps reduce the visibility of fine lines and wrinkles retaining moisture to the skin, creating a plumping effect. (
  • You apply the eye mask first, then layer and cover it up with this Pristine Bio-Cellulose Stem Cell Mask. (
  • Myelodysplastic syndromes (MDS) are clonal disorders of the hematopoietic stem cell characterized by ineffective hematopoiesis leading to peripheral cytopenias. (
  • Myelodysplastic syndromes (MDS) constitute a group of heterogeneous clonal hematopoietic stem cell disorders with a propensity to evolve into acute myeloid leukemia (AML). (
  • Cellular senescence is a state of stable cell cycle arrest associated with macromolecular alterations and secretion of proinflammatory cytokines and molecules. (
  • To keep cells fully charged, mitochondria operate four biochemical production lines that coalesce with oxygen molecules from normal respiration to produce ATP. (
  • Cell membranes are dynamic, fluid structures, and most of their molecules are able to move about in the plane of the membrane. (
  • But it's a hard thing to measure the squishy dynamics of individual molecules inside a cell, where mysterious, overlapping processes roil chaotically as minute structures form and dissolve a thousand times per second. (
  • Here, we discuss how the incorporation of high-resolution structural data can provide key molecular details often necessary to understand the complex connection between individual molecules and cell behavior. (
  • This complex process includes changes in morphology to allow migration to lymphoid organs, expression of essential receptors and costimulatory molecules on the cell surface, and a shift from a capturing state to a cytokine-secreting and antigen-presenting profile. (
  • DCs that have migrated to draining lymph nodes will present the processed antigen on MHC and MHC-like molecules to naive T cells, leading to the formation of effector cells and, hence, the required immune response (Figure 1). (
  • This collection contains the list of the articles published in Cell Reports in the cancer biology field and is updated on a weekly basis. (
  • Cancer cell identity and plasticity are required in transition states, such as epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), in primary tumor initiation, progression, and metastasis. (
  • Both kinds of events can be fatal to the affected cell, though in some circumstances, this can be beneficial to animals, as demonstrated by taxol, which is commonly used as a cancer medication. (
  • Dr. Kannan recommends exploring these professional and patient resources related to stem cells, cancer biology and breast cancer. (
  • Specific interests include studying molecular determinants of treatment resistance in breast cancer stem cells and novel treatment of inflammatory breast cancer. (
  • She carried out her PhD research in the Neurobiology Department of the Harvard Medical School and the Cancer Biology Department of the Dana Farber Cancer Center, Boston, USA. (
  • Other current research interests are (brain) cancer biology, tissue engineering and bio-electronic circuits. (
  • An international team of researchers led by University of Minnesota Twin Cities engineers have found that cancer cells can gravitate toward certain mechanical 'sweet spot' environments, providing new insights into how cancer invades the body. (
  • During the study, Odde and his team looked at both brain cancer and breast cancer cells. (
  • The research team also found that some cells, like the breast cancer cells they studied, have a feedback mechanism that causes them to grip more strongly onto stiffer environments, which explains why many previous studies showed cells moving to the stiffer side. (
  • We're basically decoding how cancer cells invade tissue,' Odde said. (
  • The next step for the researchers is to use this information to build a simulator that shows how cancer cells move through an entire tumor, which will help them better predict cells' movements based on their environments. (
  • The sample will contain your own DNA and possibly the DNA of a pathogen or cancer cell. (
  • Le Président du Conseil de Direction domaine de la recherche sur le cancer biennal 2016-2017 a été approuvé en mai prépare les réunions avec le Secrétariat et les domaines connexes. (
  • Microtubules, which are about 25 nanometers in diameter, form part of the cytoskeleton that gives structure and shape to a cell, and also serve as conveyor belts moving other organelles throughout the cytoplasm. (
  • C. All cells have static organelles D. All cells have cell walls. (
  • The mitochondrion (the singular of mitochondria) is of one of several distinct compartments, or organelles, in the cell cytoplasm. (
  • Inside eucaryotic cells, the membranes of the endoplasmic reticulum, Golgi apparatus, mitochondria, and other membrane-enclosed organelles maintain the characteristic differences between the contents of each organelle and the cytosol. (
  • Peroxisomes are ubiquitous cell organelles that are essential in man. (
  • Organelles and components of the cell. (
  • We'll talk more about the nucleus and organelles in the next article on eukaryotic cells, but the main thing to keep in mind for now is that prokaryotic cells are not divided up on the inside by membrane walls, but consist instead of a single open space. (
  • This course is a study of the fundamental activities of cell organelles and their form and function as exemplified in plant and animal cells as well as the ultra-structure of cells. (
  • Studies of viral attachment to cultured gastrointestinal epithelial cells (Caco-2) using recombinant virus-like particles or infectious noroviruses indicate that specific histo-blood group antigens play a key role in the attachment of the virus to the host cells ( 13 - 17 ). (
  • We summarize results from 4 different infectivity trials that used 3-D small intestinal epithelial cells ( Table 1 ). (
  • This month, we host a free, virtual Nature Conference with Nature Metabolism and Nature Reviews Molecular Cell Biology , ' Metabolic Communication Across Biological Scales ', and highlight recent articles that enrich our understanding of cellular metabolism in health and disease. (
  • The combination of genetic and cell biological approaches allows for synergy in functional understanding of genetic variations and rapid application of new knowledge into clinical practice. (
  • Systems biology seeks to explain complex biological systems, such as the cell, through the integration of many different types of information. (
  • Selected topics on human diseases in which basic cell biological processes are defective will be explored in-depth using contemporary primary cell biology literature as the principal resource. (
  • Count biological cells faster and more accurately. (
  • PLOS Biology provides an Open Access platform to showcase your best research and commentary across all areas of biological science. (
  • The Department of Biological Sciences at Lehigh University invites applications for a tenure track position at the level of Assistant Professor in the area of Cell Biology, broadly defined. (
  • Biology Internet Library - has a cellular biology section. (
  • We seek outstanding applicants studying fundamental processes related to cellular biology, for a position beginning in the Fall, 2023. (
  • For example, you can enroll in a Masters of Chemical and Life Science , Ph.D. in Cell Biology and Anatomy , or a Bioenergy Graduate Certificate program. (
  • Epinephrine cannot diffuse through the cell membrane. (
  • The plasma membrane encloses the cell, defines its boundaries, and maintains the essential differences between the cytosol and the extracellular environment. (
  • Three views of a cell membrane. (
  • A) An electron micrograph of a plasma membrane (of a human red blood cell) seen in cross section. (
  • B and C) These drawings show two-dimensional and three-dimensional views of a cell membrane. (
  • Although we focus mainly on the plasma membrane, most of the concepts discussed are applicable to the various internal membranes in cells as well. (
  • Explain and describe evidence for the ionic basis of the resting potential membrane and action potential in excitable cells. (
  • The sarcoglycan protein complex is located in the membrane surrounding muscle cells. (
  • The layer consisted of large cells with small nucleus, free-organelle cytosol, irregular plasmatic membrane, trichome- like structures, and thick cell walls. (
  • Recognise and be able to describe the structure and function of key components of eukaryotic and prokaryotic cells. (
  • Characteristics of prokaryotic cells. (
  • Typical prokaryotic cells range from 0.1 to 5.0 micrometers (μm) in diameter and are significantly smaller than eukaryotic cells, which usually have diameters ranging from 10 to 100 μm. (
  • The Division of Cell Biology is comprised of 15 full time primary faculty members with wet lab-based multi-disciplinary research programs focused broadly on lung injury, inflammation, cell biology, immunology, development, remodeling, repair and lipid mediator biology. (
  • Several faculty members from the Pediatric Pulmonary and Allergy/Immunology Divisions, as well as the Departments of Medicine and Biomedical Research have secondary appointments in the Program in Cell Biology. (
  • Golgi outposts can nucleate new microtubules in specialized cells with unique cytoarchitectures, including Drosophila neurons, mouse muscle cells, and rodent oligodendrocytes. (
  • Neurobiology is intrinsically multi-disciplinary, spanning from molecular biology and gene regulation in neurons, to chemical and electrical signaling in neurons, to information processing by neural circuits and brain regions, to nervous system development and plasticity. (
  • In this course, we will explore the underlying biology behind the idea of using stem cells to treat disease, specifically analyzing the mechanisms that enable a single genome to encode multiple cell states ranging from neurons to fibroblasts to T cells. (
  • There is so much we don't yet know about these cells, including how the centrosomes of neurons compare to those of neural stem cells and other cell types," Götz says. (
  • The scientists discovered that a specific protein (the ubiquitously expressed splicing protein PRPF6) is enriched at the centrosome in neural stem cells, but not in neurons. (
  • The little grey cells that make up your mind are primarily neurons. (
  • Brain cells, or neurons, are the building blocks of the nervous system. (
  • The cell body has branching dendrites coming off of it in order to receive signals from other neurons. (
  • For additional information contact Dr. Kathy Iovine, Chair, Cell Biology Search Committee at [email protected] or by mail at 111 Research Drive, Bethlehem, PA 18015. (
  • Cell and molecular biology graduate programs are designed to train students for possible careers in industries such as healthcare, botany and agriculture, and biotechnology. (
  • A background in cell and molecular biology will prepare you for a variety of careers in the growing field of biotechnology, where you can help develop new medications, treatments and breakthrough research. (
  • Through this dynamic blend of coursework, you'll gain the foundation you need to pursue a career in biotechnology and advanced degrees in laboratory biology, medicine, veterinary medicine, dentistry, pharmacy and physician assistantships. (
  • This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. (
  • The Division of Cell Biology is a research program in the Department of Pediatrics. (
  • Dr. Riches serves as Head of the Division of Cell Biology in the Department of Pediatrics. (
  • Dr. Henson is in the Division of Cell Biology and Department of Pediatrics. (
  • Members of the Department are very actively involved in teaching virology, cell biology, molecular biology, anti-viral immunity, infectious diseases, vaccination and computer certification (PIX). (
  • Within a multidisciplinary, collaborative research environment in the department and across the university, the successful candidate is expected to develop an internationally recognized, extramurally funded research program, participate in the department's Ph.D. program in biology, and contribute to the department's excellence in undergraduate and graduate teaching. (
  • Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, 00128 Rome, Italy. (
  • Dean's honor list (top 3% of undergraduate students in all majors) and highest averages and cumulative average (96/100) in graduate courses in the Biology Department records, American University of Beirut, Lebanon (2009 - 2002). (
  • The mitochondria also appear to synchronize their movements not only in an individual cell but, quite unexpectedly, into a linked network of oscillators vibrating throughout the tissue. (
  • Neurobiology is the study of the brain and nervous system, which are the cells and tissue that generate sensation, perception, movement, learning, emotion, and many of the functions that make us human. (
  • In a previous study, the University of Minnesota-led team found that cells have the ability to sense the stiffness of their environment-;which ranges from stiff (bone tissue) to soft (fatty tissue) to medium stiffness (muscle tissue)-;and their ability to move is dependent upon that environment. (
  • Mathias Jakob Schleiden and Theodor Schwann proposed the theory that the nervous system should theoretically be composed of cells like all other organic tissue. (
  • 7.349 Stem Cells: A Cure or Disease? (
  • You just viewed 7.349 Stem Cells: A Cure or Disease?... . (
  • For case reaping hook cell disease, thalassaemia, Cystic fibrosis are the illustrations of monogenetic upset which are caused due to a peculiar familial mutant. (
  • Sickle Cell Disease (SCD) is a monogenetic upset in hemoglobin doing the Red Blood Cells (RBC) to organize an unnatural reaping hook form. (
  • Sickle cell disease consequences into decreased life anticipation with mean life being 42 old ages and 48 old ages in affected males and females severally. (
  • This procedure finally consequences in ischemia.The anaemia in reaping hook cell disease is caused byA haemolysis due to the devastation of the RBCs inside the lien. (
  • The tests work by finding the DNA or RNA of a pathogen (disease-causing organism) or abnormal cells in a sample. (
  • MicroRNAs (miRNAs) are a class of short non-coding RNA that play important roles in disease processes in animals and are present in a highly stable cell-free form in body fluids. (
  • Elvis did it, Michael Jackson did it, and so do the mitochondria in our cells. (
  • Although mitochondria are jacks of many biochemical trades, they are best known as the power plants of the cell. (
  • The phrase lives of a cell refers to the independent yet interrelated parts of a human cell including mitochondria, centrioles, and basal bodies that once led independent lives. (
  • Overall, 55 faculty at Berkeley (in MCB and other departments) conduct neurobiology research, reflecting the diversity and importance of this field within modern biology. (
  • All Neurobiology majors receive essential coursework in molecular and cell biology, as well as rigorous training in specific neurobiology courses. (
  • In stomach cells protein digesting enzymes are stored in the inactive form Once the enyme leave the stomach an acid in the stomach changes the shape of the inactive enzyme making it active Why must the protein digest exymes be stored in the inactive form? (
  • In Chapters 12 and 13 we discuss the internal membranes of the cell and the protein traffic through and between them. (
  • image: Princeton researchers have developed a framework to engineer the protein droplets that organize crucial functions inside a cell. (
  • Then to test the theory, Shimobayashi turned to an advanced protein tool developed in Brangwynne's lab in 2018 that provided an ideal, simplified system that mimics how the process occurs naturally in cells. (
  • In particular, our research can explain for the first time why a protein that is present in all cells, after mutation, causes a phenotype only in the brain, but not in other organs. (
  • Bone /RCC models were generated, coculturing green fluorescent protein (GFP)-tagged Caki-1 and 786-O cells with human primary OBs in a " cell - cell contact" system. (
  • At this point, it is just a matter of generating more powerful optics to visualize the chemistry of life that really unfolds in the body, not under artificial laboratory conditions that stress cells and likely modify their behavior. (
  • These findings emphasize how important it is scientifically to study biology on its own terms, not under artificial laboratory conditions," said Natalie Porat-Shliom, an NIDCR scientist and lead author on the paper. (
  • My recent experimental and theoretical studies have been focused on an analysis of the "codes" with which nerve cells in sensory systems represent information about external stimuli, the neural mechanisms through which that information is processed within subsequent stages of the nervous system, and the extent to which the nervous system may have become optimized through evolution. (
  • However, the exact mechanisms of action and the extent to which different cells are involved still need to be elucidated. (
  • Targeted therapies and immune checkpoint inhibitors have advanced the treatment landscape of Renal Cell Carcinoma (RCC) over the last decade. (
  • Antitumor Effect of Cabozantinib in Bone Metastatic Models of Renal Cell Carcinoma. (
  • The presence of bone metastases in renal cell carcinoma (RCC) negatively affects patients ' survival . (
  • Here, we evaluated the antitumor effect of cabozantinib in coculture models of renal cell carcinoma (RCC) and osteoblasts (OBs) to investigate whether and how its antiproliferative activity is influenced by OBs. (
  • If you are interested in the inner workings and structure of organisms, you should consider earning a graduate degree in molecular biology. (
  • The centrosome is the organelle responsible for the organization of the cytoskeleton during cell division, an essential function in organisms from yeast to humans. (
  • Temporally and spatially organized cell fate transitions are at the basis of the genesis of multicellular organisms and alterations from this body plan can generate pathologies. (
  • We and other multicellular organisms contain billions or trillions of cells organized into complex structures, but many organisms consist of a single cell. (
  • Even simple unicellular organisms exhibit all the hallmark properties of life, indicating that the cell is the fundamental unit of life. (
  • Large organisms such as human beings average about one mutation per ten gametes [a gamete is a sex cell, either sperm or egg] -- that is, there is a 10 percent chance that any given sperm or egg cell produced will have a new and inheritable change in the genetic instructions that make up the next generation. (
  • report that epidermal differentiation is a multi-day process through which cells undergo a continuum of transcriptional alterations initiated independently of cell cycle exit. (
  • Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. (
  • In recent years, the Golgi outpost has emerged as a satellite organelle that can function as an acentrosomal microtubule-organizing center (MTOC), nucleating new microtubules at distances far from the nucleus or cell body. (
  • In an animal cell, it is this end that is located at the centriole-containing centrosome found near the nucleus, while the plus end, comprised of exposed beta -units, is projected out toward the cell's surface. (
  • All Biology majors require the 26-credit Biology Nucleus. (
  • Shoot tips of maize are composed of small cells with a dense cytoplasm and a prominent nucleus. (
  • In the inner cell layer, small and isodiametric cells with a prominent nucleus, small vacuoles, endoplasmatic reticulum, Golgi, mitochondrias and chloroplasts were observed. (
  • Presented in Figure 2 is a digital image of the microtubule network found in an embryonic mouse cell as seen through a fluorescence optical microscope. (
  • These straight, hollow cylinders are found throughout the cytoplasm of all eukaryotic cells (prokaryotes don't have them) and carry out a variety of functions, ranging from transport to structural support. (
  • Cytoplasm consists of the jelly-like cytosol inside the cell, plus the cellular structures suspended in it. (
  • Partial induced pluripotent cells (iPSCs) are cell lines strayed from normal route from somatic cells to iPSCs and are immortalized. (
  • which bipolar structures that resemble zygotic nevertheless, improvement through genetic embryos are developed from haploid or diploid engineering or mutagenesis requires a reliable somatic cells through an orderly embryologi- and efficient in vitro culture system. (
  • Since eukaryotic cells greatly depend upon the integrity of microtubules and other cytoskeletal filaments to maintain their structure and essentially to survive, many plants produce natural toxins aimed at disrupting the microtubule network as a means of self-defense. (
  • Animals, plants, fungi, and protists are all eukaryotes- eu means true-and are made up of eukaryotic cells. (
  • The movements could last from tens of seconds to minutes, which was far longer and frequently at a faster tempo than observed previously in cell culture," said Roberto Weigert, Ph.D., an NIDCR scientist and senior author on the study. (
  • German scientist Heinrich Wilhelm Gottfried von Waldeyer-Hartz gave this cell the name "neuron" in 1891. (
  • Recent advances in single cell analyses enable addressing these research topics with unprecedented sensitivity, while constantly improving strategies for germline editing raise possibilities for translating basic science findings into biomedical and biotechnological applications. (
  • The best molecular biology graduate programs also prepare professionals for possible work in government agencies and teaching at the university level. (
  • For many years, scientists have thought that cells would always gravitate toward a stiffer environment, but the University of Minnesota researchers observed for the first time that cells can actually move toward a 'sweet spot' that's more in the middle. (
  • A. All cells are motile B. All cells have internal structures that move. (
  • What structures or components must a cell contain to be alive? (
  • The team next turned back to the messy complexity of native cell structures. (
  • The structures for several enzymes that regulate fatty acylation have been identified recently, aiding the "druggability" of these targets for therapeutic gain as well as parsing apart their roles in cell biology. (
  • As the twenty-first century opens, we face an explosion of new data about the components of cells, what structures they contain, how they touch and influence each other. (
  • Research in structural virology aims to provide a molecular description of the dynamics of viral structures at various essential stages of the infectious cycle: assembly of the viral particle, fusion of viral and cell membranes, packaging and ejection of the viral genome. (
  • Some bacteria also have specialized structures found on the cell surface, which may help them move, stick to surfaces, or even exchange genetic material with other bacteria. (
  • Fimbriae are numerous, hair-like structures that are used for attachment to host cells and other surfaces. (
  • Because the field of biology touches so many parts of the world, the best molecular biology graduate programs have a number of academic programs at the masters and doctorate degree level. (
  • A degree from a molecular biology graduate school might involve earning a teaching credential or graduate degree for possible teaching at the K-12 or college level. (
  • The most widely accepted grading schema for astrocytomas is the World Health Organization [WHO] that assigns a grade from I to IV based on the degree of anaplasia of tumor cells, proliferation index values and genetic alterations. (
  • Intense research centers on the origin of these cells, how can they be recognized, how they are regulated at the genetic and epigenetic levels, and how their properties and behavior affect resulting embryos. (
  • This conference will bring together leading scientists at the forefront of international research in the germ cell field in a range of vertebrate (primarily mammalian) systems. (
  • This research employs X-ray crystallography and structural electron cryo-microscopy that will be enriched in the near future by in situ structural biology technologies. (
  • Their research showed that the cells can have a 'sweet spot' of stiffness, that isn't too hard or too soft, in which they have better traction and can move faster. (
  • 5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (
  • Recently, the first in vitro norovirus cell culture model was reported for a virus that infects mice ( 18 , 19 ). (
  • Urate has anti-oxidant effects, is protective to dopaminergic cells in vitro and in vivo, and may be lower in post-mortem brains of PD patients. (
  • Cell membranes are crucial to the life of the cell. (
  • The functions of cell membranes are considered in later chapters. (
  • Identify each of the main steps involved in the cell cycle and consequences of the process going wrong. (
  • Another example is the translocation of vesicles containing neurotransmitters by microtubules to the tips of nerve cell axons. (
  • Like ourselves, the individual cells that form our bodies can grow, reproduce, process information, respond to stimuli, and carry out an amazing array of chemical reactions. (
  • If a cell is very active and needs more energy, what type of organelle will it need more of? (
  • This approach is common in materials science, but we've adapted it to do something unprecedented in cells,' said principal investigator Clifford Brangwynne, the June K. Wu '92 Professor in Engineering and director of the Princeton Bioengineering Initiative. (
  • The stratum spinosum is the thickest layer of the epidermis and contains multiple polygonal spiny cells rich in cytokeratin and with desmosomal intercellular connections. (