Ozone therapy

Institute for Bioengineering of Catalonia

Spinal cord injury

Pfizer

Spinal cord injury research

Food and Drug Administration

3H Biomedical

Regenerative medicine

Cell encapsulation

Cell bank

Neural Regeneration Research

Allogeneic processed thymus tissue

Tissue engineering of heart valves

Photoimmunotherapy

W. Mark Saltzman

Cell-based therapies for Parkinson's disease

Stephen J. Lippard

Alternating electric field therapy

Photothermal therapy

Molecular pathological epidemiology

ISM radio band

Spencer Trask & Co.

Glassy cell carcinoma of the cervix

January-March 2022 in science

RNA therapeutics

Muse cell

Natural killer cell

Ethan M. Shevach

Bioceramic

Cyclophosphamide

Hemoencephalography

Phage display

Prostaglandin-endoperoxide synthase 2

Cervical cancer

Biliblanket

Brain ischemia

Papillary carcinomas of the breast

Multiple system atrophy

Catenin

CD278

Selpercatinib

Interferon

Rocky Mountain spotted fever

Esthesioneuroblastoma

Achilles tendinitis

Mitochondrial DNA

Paul J. Turek

Mineral (nutrient)

Selective androgen receptor modulator

ZTTK syndrome

Calcific tendinitis

List of laser applications

Spinal cord

Pembrolizumab

Cell cycle

Axel Ullrich

List of Puerto Rican scientists and inventors

Short interspersed nuclear element

Iron overload

Cerebral amyloid angiopathy

Regenerative Therapies2

• The Laboratory of Regenerative Therapies for Inherited Blood Disorders, led by Dr. Andre Larochelle, is investigating novel strategies and stem cell concepts that can help advance the translational regenerative field, with a focus on inherited disorders affecting blood-forming hematopoietic stem cells (HSCs). (nih.gov)
• Gene and stem cell-based regenerative therapies hold the promise of restoring lost, damaged, or aging cells and tissues in the human body. (nih.gov)

Adipose6

• Cell sources included gingiva , periodontal ligament (PDL), bone marrow , and adipose tissues . (bvsalud.org)
• The expression pattern of pluripotency markers in adipose tissue-derived stem cells (ADSCs) is a subject of controversy. (hindawi.com)
• These findings showed that mouse adipose tissue contains a population of cells with molecular resemblance to embryonic stem cells, and LIF and miR-302 family positively affect the expression of pluripotency markers. (hindawi.com)
• White adipose tissue represents a rich source of stem cells with potential applications in basic and clinical research. (hindawi.com)
• Adipose tissue-derived stem cells (ADSCs) can be harvested from patients by a simple and minimally invasive method. (hindawi.com)
• ADSCs were isolated from the inguinal adipose tissue of 10-12-week-old Balb/c mice using 2 mg/mL collagenase A (Roche, Mannheim, Germany) digestion, as previously described [ 9 ]. (hindawi.com)

Translational7

• The findings of this systematic review demonstrated the therapeutic potential of certain cell -based therapies in promoting periodontal healing following delayed replantation , thus highlighting their prospective clinical benefits and translational value. (bvsalud.org)
• This highlights the potential clinical benefits and translational value of cell -based therapy for the replantation of avulsed teeth . (bvsalud.org)
• To meet the goals of an accelerated translational timeline, DOCTRC will employ tissue regeneration tools and approaches that previously have been tested in small animal models, and which have demonstrated significant translational potential and readiness to be tested in DOC disease-relevant large animal models. (nih.gov)
• The goal of stage 3 will be to advance specific tissue regeneration strategies through the translational pipeline to complete their validation and preclinical testing. (nih.gov)
• This course will highlight basic, translational, and clinical advances in cell-based therapies and tissue engineering, with some discussion of ethical, financial, and regulatory issues that may impact such advances. (wustl.edu)
• This program supports basic and translational research in the repair, regeneration, and restoration of function of injured and/or diseased musculoskeletal tissues using stem cell biology and engineering-based approaches. (nih.gov)
• The current challenge of the group is to develop new generation translational products for cytotherapy-based cancer management and screening of drugs. (eie.gr)

Pluripotent14

• Using human induced pluripotent stem cells (hiPSC), Dr. Canto-Soler and her research team established a method that led for the first time to the generation of light-sensitive miniature human retinas in a laboratory dish. (nih.gov)
• Dr. Larochelle's group is developing and optimizing this technology for the genetic correction of human HSCs and pluripotent stem cells. (nih.gov)
• There are several main categories: the "pluripotent" stem cells (embryonic stem cells and induced pluripotent stem cells) and nonembryonic or somatic stem cells (commonly called "adult" stem cells). (nih.gov)
• Pluripotent stem cells have the ability to differentiate into all of the cells of the adult body. (nih.gov)
• Those reprogramed stem cells are called induced pluripotent stem cells (iPSCs). (nih.gov)
• The specific factors and conditions that allow pluripotent stem cells to remain undifferentiated are of great interest to scientists. (nih.gov)
• It has taken many years of trial and error to learn to derive and maintain pluripotent stem cells in the laboratory without the cells spontaneously differentiating into specific cell types. (nih.gov)
• We are working to generate red blood cells in vitro from pluripotent stem cells, however the extremely large cell numbers involved pose unique challenges to culture technology and scale-up. (selectbiosciences.com)
• Novel culture and cryopreservation systems for human pluripotent stem cells and neural stem cells will be presented and their advantages and applicability in the production of high quality advanced therapeutic products or functional screening tools for preclinical research discussed. (selectbiosciences.com)
• This presentation will describe the current status of strategies to generate induced pluripotent stem (iPS) cells from mouse and human somatic cells for patient-specific disease modeling and cell therapeutic applications. (selectbiosciences.com)
• This protocol describes the reprogramming of primary amniotic fluid and membrane mesenchymal stem cells into induced pluripotent stem cells using a non-integrating episomal approach in fully chemically defined conditions. (jove.com)
• Procedures of extraction, culture, reprogramming, and characterization of the resulting induced pluripotent stem cells by stringent methods are detailed. (jove.com)
• The overall goal of this procedure is to efficiently derive induced pluripotent stem cells by means of episomal reprogramming from two different kinds of fetal stem cells. (jove.com)
• This method can help provide a source of pluripotent stem cells for tissue engineering, disease modeling, basic research, or longitudinal studies. (jove.com)

Bone marrow6

• 3) Drug Therapy: Investigations of the mechanisms of action of eltrombopag and clinical applications in patients with inherited bone marrow failure (Fanconi anemia, Diamond Blackfan Anemia). (nih.gov)
• Some children have been successfully treated with blood stem cell, or bone marrow, transplants. (nih.gov)
• These include bone marrow transplants, which have been transformational for many cancer patients, and therapies for blood and immune system disorders. (nih.gov)
• Peroni and colleagues [ 6 ] showed that bone marrow-derived mesenchymal stem cells (BM-MSCs) and ADSCs have a virtually identical transcriptional profile for stemness-related genes. (hindawi.com)
• Lymphoma is a blood cell cancer - a condition where abnormal lymphocytes (a type of white blood cell) expand in number forming tumors often in lymph nodes but also in other regions, such as the bone marrow. (lymphomation.org)
• These malignant cells then may accumulate to form tumors that may enlarge the lymph nodes or spread to other areas of the lymphatic system , such as the spleen or bone marrow. (lymphomation.org)

Organs3

• Regenerative medicine focuses on the development of novel therapies to repair, replace, restore or regenerate cells, tissues and body organs that are defective, damaged or injured by disease. (wustl.edu)
• The inner cell mass will ultimately develop into the specialized cell types, tissues, and organs of the entire body of the organism. (nih.gov)
• Adult stem cells have been identified in many organs and tissues and are generally associated with specific anatomical locations. (nih.gov)

Cellular Therapies3

• AGI Town Hall, " Advancing Cellular Therapies to the Clinic . (nih.gov)
• Existing biotech business models are sorely stretched when applied to cellular therapies. (selectbiosciences.com)
• AABB and other standards and accreditation programs have been working to implement ISBT-128 labeling - a standardized system widely used in the blood banking, tissue and cellular therapies industries - to preserve the traceability of tissue products. (aabb.org)

Therapeutics6

• At CellSight, Dr. Canto-Soler and colleagues are currently using this breakthrough technology to develop novel stem cell-based therapeutics to save and restore sight in patients with blinding diseases. (nih.gov)
• Everyone, I welcome you all to the NIMH virtual workshop on gene based therapeutics for genetic neurodevelopmental disorders. (nih.gov)
• Today we have a panel of experts from academia, government and industry to share some success stories and their perspectives on challenges and opportunities in developing gene based therapeutics for individuals with rare genetic neurodevelopmental disorders. (nih.gov)
• Specifically we will review the current state of science in gene based therapeutics including gene targeted approaches, vector design and delivery options, characteristics of suitable gene molecular targets and mechanisms amenable to gene based therapies. (nih.gov)
• Details are provided about the quantitative market opportunity for various stem cell classes as well as the current state of the clinical trials space wherein stem cell-based therapeutics are being evaluated for therapy in various disease classes. (selectbiosciences.com)
• Dr Vasilis Zoumpourlis' group has recently extended its activities towards the intriguing research of stem cells and their applications in cancer therapeutics. (eie.gr)

Ligament3

• The results showed that certain cell -based therapies significantly increased the formation of new periodontal ligament and reduced adverse healing outcomes of replacement root resorption and ankylosis . (bvsalud.org)
• Why didn't we just make the broken part of the ligament heal with tissue engineering like we do with everything else now? (aaos.org)
• Because blood centers and transfusion services may store and dispense tissues (i.e., bone, ligament, and skin), these products are addressed in the general quality system requirements of the AABB Standards. (aabb.org)

Embryonic stem3

• With the development of iPSC technologies via transient expression of embryonic stem cell (ESC) transcription factors in somatic cells emerged the concept of generating iPSCs from an individual patient, correcting the genetic defect using genome editing approaches (e.g. (nih.gov)
• In 2006, researchers identified conditions that would allow some mature human adult cells to be reprogrammed into an embryonic stem cell-like state. (nih.gov)
• To advance lung regenerative medicine, we are designing bioengineered lung tissue, which includes embryonic stem cell (ESC)-derived airways, alveoli and vasculature for future medical applications. (cincinnatichildrens.org)

Extracellular4

• As a leading researcher in vision, Dr. Canto-Soler has a recent publication that provides the first evidence that proteins known to form drusen, which are yellowish deposits that accumulate under the retina and that contribute to age-related macular degeneration (AMD), are released and directionally sorted in extracellular vesicles from retinal pigment epithelium (RPE) cells. (nih.gov)
• Such scaffolds can be designed to recapitulate the properties of extracellular matrices of natural tissues, deliver active biomolecules to cells, degrade at a pre-determined rate, control inflammatory responses, and exhibit many other useful properties. (nih.gov)
• Here, we show that Treg use heparanase (HPSE) to access IL-2 sequestered by heparan sulfate (HS) within the extracellular matrix (ECM) of inflamed central nervous system tissue. (biorxiv.org)
• One-Sentence Summary Regulatory T cells use heparanase to strip IL-2 bound to extracellular matrix within inflamed tissues, thereby supporting their homeostasis and function. (biorxiv.org)

Differentiation5

• Also, important strides have been made in elucidating the mechanisms of DOC tissue-specific stem and progenitor cell function, and deriving new tools and technologies for cell isolation, expansion, and differentiation. (nih.gov)
• Single cell transcriptomic (scRNAseq) and chromatin accessibility (ATAC-seq) comparison of bona fide HSCs and hematopoietic cells generated using this culture system will allow the identification of essential genetic programs that current differentiation protocols fail to activate. (nih.gov)
• Signals for cell differentiation include factors secreted by other cells, physical contact with neighboring cells, and certain molecules in the microenvironment. (nih.gov)
• Also included in the cocktail is a small molecule called RepSox, which mediates stem cell differentiation. (nih.gov)
• While both of these compounds have been used in stem cell research, their combined effect on muscle stem cell proliferation and differentiation was a novel finding in this study, said Li. (nih.gov)

Vitro3

• For example, numerous synthetic and natural scaffolds have been developed to promote maturation of engineered constructs in vitro or facilitate tissue regeneration in vivo . (nih.gov)
• Pathways of human organogenesis - how cells self-assemble into complex tissues in vitro and in vivo . (nih.gov)
• To this end, the group recently transferred its long-term experience and know-how in molecular biology of cancer in the emerging field of stem-cell biology, in order (a) to design stem cell-based vehicles for effective and specific tumor targeting and (b) to develop improved in vitro preclinical assays for quick and reliable assessing of toxicology and safety profiles of drugs. (eie.gr)

Clinic5

• AGI Town Hall, " Bringing Regenerative Medicine Therapies to the Clinic . (nih.gov)
• Hermann Agis is Head of the Competence Center for Tissue Engineering and Cell-Based Therapies, University Clinic of Dentistry, MedUni Vienna. (medworm.com)
• A 2017 report described one Florida clinic that blinded patients with stem cell eye injections. (nih.gov)
• Our clinic at Stanford recently cared for a patient who had received stem cell injections behind his eyes, where he developed tumors that ultimately ruined vision in both eyes. (nih.gov)
• Progress in stem cell science is rapidly translating to the clinic, but it is not yet the miracle answer we envision. (nih.gov)

Safety and efficacy2

• Furthermore, robust functional assays have been developed for testing the safety and efficacy of Tissue Engineering and Regenerative Medicine (TE/RM) protocols and for monitoring the progression of tissue regeneration in vivo . (nih.gov)
• At the same time, thousands of rogue clinics have sprung up across the U.S and around the world, offering stem cell-based therapies before being tested for safety and efficacy. (nih.gov)

Approaches2

• These approaches, known as genome editing therapies, include a range of nuclease systems that can target, cleave, and repair specific genomic sequences at sites of inherited disease-generating mutations. (nih.gov)
• Various approaches are being investigated, including activation of Notch and hypoxic pathways, regulation of the Unfolded Protein Response (UPR) in expanding HSCs, and CRISPRa/CRISPRi-based activation/inhibition of epigenetic modifiers and HSC regulators. (nih.gov)

20172

• In July 2017 she joined the Department of Ophthalmology at the University of Colorado School of Medicine as the Doni Solich Family Chair in Ocular Stem Cell Research and the Director of CellSight - the Ocular Stem Cell and Regeneration Research Program. (nih.gov)
• In 2017, it released guidance under the 21st Century Cures Act that clarifies which stem-cell based therapies fall under FDA regulation. (nih.gov)

Protocols4

• In addition, further research will be required to shed light on the implications of using allogeneic cells as well as the optimization of cell delivery protocols . (bvsalud.org)
• The outcome of the DOCTRC effort will be the development of combination products based on cells, biologics and devices and associated protocols ready for the initiation of clinical trials. (nih.gov)
• The outcome of stage 3 will be FDA-approved tissue regeneration combination products and phase 1 clinical trial protocols. (nih.gov)
• These centers would be responsible for the procurement of whole pancreata, isolation and quality control of islet cell preparations, and distribution of islets for both approved laboratory research and clinical protocols. (nih.gov)

Regeneration7

• The goal of this initiative is to establish a multidisciplinary Dental, Oral and Craniofacial (DOC) Tissue Regeneration Consortium (DOCTRC) that will develop effective clinically-applicable strategies for regeneration of functional tissues of the human dental, oral and craniofacial complex. (nih.gov)
• To this end, each RC will develop, optimize and validate tools and strategies for DOC tissue regeneration in the following areas: (i) cells and biomaterials, (ii) large animal models, (iii) functional assays, and (iv) government regulatory interactions. (nih.gov)
• Many scientific and technological advances have emerged from interdisciplinary efforts addressing reconstruction and regeneration of DOC tissues affected by disease and trauma. (nih.gov)
• The term muscular dystrophy (MD) refers to a heterogeneous group of genetic disorders that typically result in progressive degeneration followed by incomplete regeneration of skeletal muscles, ultimately resulting in the loss of contractile tissue. (medscape.com)
• Because muscle stem cells can repair damaged tissue, the investigation of stem-cell-based therapies for muscle regeneration is an area of active research. (nih.gov)
• A major bottleneck in the muscle regeneration field is the lack of an effective method to generate and proliferate muscle stem cells," said senior author Song Li, Ph.D., a professor in the departments of bioengineering and medicine at UCLA. (nih.gov)
• In all of their models, the implanted stem cells facilitated muscle repair and tissue regeneration. (nih.gov)

Transplantation2

• Therapies that involve the TRANSPLANTATION of CELLS or TISSUES developed for the purpose of restoring the function of diseased or dysfunctional cells or tissues. (nih.gov)
• Human cells, tissues, and cellular and tissue-based products (HCT/Ps) consist of human cells or tissues intended for implantation, transplantation, infusion or transfer into a human recipient. (aabb.org)

Pediatric2

• We are developing new cell-based treatments for pediatric and adult pulmonary diseases. (cincinnatichildrens.org)
• The main advantage of this technique is that the reprogramming and the maturation of iPSCs transpires in chemically defined conditions while being available early for potential pediatric cell-based therapies. (jove.com)

Mechanisms2

• Topics will explore endocrine cell signaling, molecular mechanisms of hormone action, homeostasis and feedback systems including neuroendocrine integration of physiological processes, endocrine control of cardiovascular and calcium homeostasis, and select discussion of endocrine pathologies. (wustl.edu)
• In this study, we used a xenograft model with the human colon cancer HT-29 cells to investigate the mechanisms underlying the effect of continued administration of bevacizumab plus capecitabine even after resistance to bevacizumab was acquired. (nih.gov)

Immune5

• This approach turns local immunogenic cancer cell death (apoptosis) into a systemic anti-tumor immune response and may be implemented by treatment with intratumoral DCs. (nih.gov)
• The bone cell microenvironment consists of bone-forming osteoblasts, bone-resorbing osteoclasts, and thei precursors, as well as immune and vascular cells. (wustl.edu)
• Cell-based therapies, including the use of native stem or immune cells and genetically-modified or bioengineered cells, are being evaluated for the treatment of a wide variety of diseases such as cancer, diabetes, and Parkinson's disease. (wustl.edu)
• NIH researchers successfully treated adults with severe sickle cell disease using a modified stem cell transplant approach that doesn't require extensive immune-suppressing drugs. (nih.gov)
• Lymphoma result when DNA damage or changes occurs to an immune cell (a lymphocyte) that alters the behavior of the cells. (lymphomation.org)

Regenerate1

• This tissue has the ability to regenerate after minor injuries, a process facilitated by resident muscle stem cells that help to build new muscle fibers. (nih.gov)

Preclinical2

• While several preclinical studies have reported varied success using cell -based tissue engineering to improve periodontal healing, a consensus is required before further clinical translation. (bvsalud.org)
• This review systematically assessed the literature for preclinical studies employing cell -based therapies to promote periodontal healing following delayed replantation . (bvsalud.org)

Transplants2

• Patients afflicted with Type I diabetes mellitus have achieved long-term freedom from exogenous insulin and hypoglycemic attacks after having received human pancreatic islet cell transplants. (nih.gov)
• Its first spin-off company, ExCellThera , will soon be expanding stem cells in cord blood to improve stem cell transplants for leukemia patients. (marsdd.com)

Fetal1

• Isolated cells were counted and plated at 5 × 10 4 cells/mL seeding density in 6 cm tissue culture plates and cultured in Dulbecco's modified eagle's medium (DMEM, Gibco, Life Technologies, USA) with 20% fetal bovine serum (FBS, Gibco). (hindawi.com)

Regulates1

• The regulated gene expression determines the chemical environment of cells and tissues and thereby regulates biophysical processes. (nih.gov)

Molecular3

• Philip Osdoby's research focuses on understanding select aspects of the cell and molecular interactions that are required for normal bone development as well as those that may contribute to age-associated and inflammatory-mediated pathological bone loss. (wustl.edu)
• Improve molecular, cellular, or gene-based therapies. (nih.gov)
• In today's view, this description would infinite growth of a tumour cell within one also cover cellular and molecular blood cellular system while allowing for the produc- components, including immunoglobulins. (who.int)

Therapeutic2

• Using our drug cocktail, we can efficiently expand this cell population, harnessing their potential as a therapeutic agent for muscle repair. (nih.gov)
• The opportunities and challenges of development of stem cell-based therapeutic interventions for joint surface repair for the treatment and prevention of osteoarthritis will be discussed. (selectbiosciences.com)

Efficacy1

• Therefore, this systematic review seeks to evaluate the efficacy of cell -based therapy in promoting periodontal healing following delayed replantation in animal models . (bvsalud.org)

Murine4

• RANKL-mediated osteoclast formation from murine RAW 264.7 cells. (wustl.edu)
• Collin-Osdoby P, Yu X, Zheng H, Osdoby P. (2003) RANKL-mediated osteoclast formation from murine RAW 264.7 cells. (wustl.edu)
• HPSE expression distinguishes human and murine Treg from conventional T cells and is regulated by the availability of IL-2. (biorxiv.org)
• This employs a fusion and intended to bind to and neutralize foreign of murine B cells derived from the spleen of antigens and pathogens. (who.int)

Generally1

• Generally, cell -based therapy had increased the proportion of root surfaces displaying periodontal healing and concomitantly reduced the proportion presenting with replacement root resorption and ankylosis . (bvsalud.org)

Functional2

• Stem cells have unique abilities to self-renew and to recreate functional tissues. (nih.gov)
• Stem cells have the ability to recreate functional tissues. (nih.gov)

Proliferation4

• However, a few interventions with soy supplements warned about possible increases in cell proliferation and estrogenic activity in breast tissue. (nih.gov)
• The hypothesis for this project is that women with high soy intake throughout life show lower proliferation in breast tissue than women with low soy intake because they experienced a protective effect from soy since childhood. (nih.gov)
• At the same time, we propose that women with high soy intake in adulthood and low soy intake early in life have greater proliferation in breast tissue than women with high soy intake throughout their life. (nih.gov)
• On the stained tissue arrays, we will examine two complementary markers of proliferation that work on paraffin blocks and decline little over time, Ki67 and PCNA. (nih.gov)

Optimization1

• Cell optimization and scale-up. (nih.gov)

Mammalian1

• Early mammalian embryos at the blastocyst stage contain two types of cells - cells of the inner cell mass, and cells of the trophectoderm. (nih.gov)

Amniotic fluid1

• Some manufacturers offer stem cell-based derived products, such as "biologic eye drops" made with placenta extract or amniotic fluid to treat dry eye. (nih.gov)

Diagnosis2

• Based on this result, she received a diagnosis of obliterative bronchiolitis. (cdc.gov)
• Observation ( watchful waiting ) is often recommended as treatment is not always needed at diagnosis and the condition tends to progress very slowly and can remain stable without therapy. (lymphomation.org)

Membrane2

• Modulated electro-hyperthermia (mEHT, trade-name: oncothermia) represents a significant technological advancement in the hyperthermia field, allowing the autofocusing of electromagnetic power on a cell membrane to generate massive apoptosis. (nih.gov)
• Use the scalpel blades to transfer the minced membrane tissue mass into one tissue dissociation tube containing 4.7 milliliters of RPMI-1640 medium. (jove.com)

Regulation1

• The FDA has made substantial progress toward regulation of stem cell-based therapies. (nih.gov)

Tumor-specific1

• Cytotoxic T cell assay and ELISpot assay revealed a tumor-specific T cell activity. (nih.gov)

Disease6

• 18. DNA damage and gene therapy of xeroderma pigmentosum, a human DNA repair-deficient disease. (nih.gov)
• Throughout the life of the organism, populations of adult stem cells serve as an internal repair system that generates replacements for cells that are lost through normal wear and tear, injury, or disease. (nih.gov)
• There is no widely available cure for the inherited blood disorder sickle cell disease. (nih.gov)
• 2 Stem cell-based therapies are also being explored for neurodegenerative diseases such as stroke and Alzheimer's disease, and for countless other conditions. (nih.gov)
• It was demonstrated that second-line chemotherapy together with bevacizumab after disease progression (PD) on first-line therapy including bevacizumab showed clinical benefits in metastatic colorectal and breast cancers (ML18147 trial, TANIA trial). (nih.gov)
• Many patients have a history of autoimmune disease (disease caused by the body's immunologic attacks against its own tissues) such as Sj gren's syndrome or Hashimoto's thyroiditis, or bacterial infection of the stomach with Helicobacter pylori. (lymphomation.org)

Autologous1

• BioLife Solutions, Inc.(BioLife, a leading developer, manufacturer and marketer of proprietary clinical grade cell and tissue hypothermic storage and cryopreservation freeze media, announced that its media products are embedded into the autologous cell therapy being developed by Pittsburgh-based Cook MyoSite, a subsidiary of the Cook Group, for treatment of female stress urinary incontinence. (simonfoundation.org)

Biomaterials1

• Years later, his work with CCRM involves bringing diverse researchers and an industry consortium of nearly 50 companies together to harness stem cells, biomaterials and molecules to tackle a range of diseases. (marsdd.com)

Gene expression2

• they do not have any tissue-specific characteristics (such as morphology or gene expression pattern) that allow them to perform specialized functions. (nih.gov)
• On the other hand, adult stem cells differentiate to yield the specialized cell types of the tissue or organ in which they reside, and may have defining morphological features and patterns of gene expression reflective of that tissue. (nih.gov)

Microenvironment1

• The treatment of intratumoral dentritic cells (DCs) commonly fails because it cannot evoke immunity in a poor tumor microenvironment (TME). (nih.gov)

Prospective1

• Unfortunately, despite this progress, only a few TE/RM-based prospective therapies have reached the stage of clinical trials. (nih.gov)

Repair7

• 9. Complementation of the DNA repair deficiency in human xeroderma pigmentosum group a and C cells by recombinant adenovirus-mediated gene transfer. (nih.gov)
• Real-time, non-invasive modalities to track cells, and/or monitor tissue-function repair and integration process in vivo . (nih.gov)
• These stem cells may remain quiescent (non-dividing) for long periods of time until they are activated by a normal need for more cells to maintain and repair tissues. (nih.gov)
• However, acute muscle loss (which can happen in severe accidents), progressive muscle loss, or genetic diseases, such as muscular dystrophy, may compromise this tissue repair process. (nih.gov)
• Instead of culturing stem cells in a dish and then implanting them into a patient, Li and colleagues envision an off-the-shelf treatment for muscle repair through direct injection of their drug cocktail into damaged tissue. (nih.gov)
• They offer a theoretically unlimited source of repair cells and/or tissues. (nih.gov)
• According to researcher Martha M. Murray, MD, of Children's Hospital Boston and Harvard Medical School, management of ACL injury by repair rather than reconstruction would, if successful, have the theoretical advantages of preserving anatomy, physiology (eg, nerves and intrinsic cells), and some biomechanics. (aaos.org)

Blood3

• Unlike muscle cells, blood cells, or nerve cells-which do not normally replicate- stem cells may replicate many times. (nih.gov)
• Yet they can give rise to all of the differentiated cells in the body, such as heart muscle cells, blood cells, and nerve cells. (nih.gov)
• Remove blood clots from the membranes, and then use a pair of fine scalpels to mince the membranes into fine pieces in a sterile 10-centimeter tissue culture dish. (jove.com)

Treatments4

• 1 Other approved treatments include dental uses for gum and tissue growth and in skin for burns. (nih.gov)
• These unproven, unregulated stem cell treatments carry significant risk. (nih.gov)
• Further, even if patients avoid adverse events from these therapies, they may suffer consequences from delaying evidence-based treatments. (nih.gov)
• A 2021 study estimated that there are over 2,500 U.S. clinics selling unproven stem cell treatments. (nih.gov)

Vivo1

• FOXP3 + regulatory T cells (Treg) depend on exogenous IL-2 for their survival and function, but circulating levels of IL-2 are low, making it unclear how Treg access this critical resource in vivo . (biorxiv.org)

Adverse3

• Integrate engineered tissues with the host while reducing adverse effects (e.g., immunogenicity, toxicity). (nih.gov)
• The Pew Charitable Trusts gathered 360 reports of adverse events related to unapproved stem cell therapies, including 20 cases that caused death. (nih.gov)
• HCT/Ps are subject to the regulations in 21 CFR 1271 including establishment registration , donor eligibility (donor screening and testing) , Current Good Tissue Practice (CGTP) , additional regulatory requirements (adverse reaction reporting, HCT/P deviation reporting and labeling) , and exemptions and alternative procedures . (aabb.org)