Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
The medical specialty which deals with WOUNDS and INJURIES as well as resulting disability and disorders from physical traumas.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC
The process of bone formation. Histogenesis of bone including ossification.
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
Individual's rights to obtain and use information collected or generated by others.
Experimentation on STEM CELLS and on the use of stem cells.
A publication issued at stated, more or less regular, intervals.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Fibrous bands or cords of CONNECTIVE TISSUE at the ends of SKELETAL MUSCLE FIBERS that serve to attach the MUSCLES to bones and other structures.
A strong ligament of the knee that originates from the posteromedial portion of the lateral condyle of the femur, passes anteriorly and inferiorly between the condyles, and attaches to the depression in front of the intercondylar eminence of the tibia.
The MUSCLES, bones (BONE AND BONES), and CARTILAGE of the body.
Rebuilding of the ANTERIOR CRUCIATE LIGAMENT to restore functional stability of the knee. AUTOGRAFTING or ALLOGRAFTING of tissues is often used.
Application of principles and practices of engineering science to biomedical research and health care.
Devices which can substitute for normally functioning KIDNEYS in removing components from the blood by DIALYSIS that are normally eliminated in the URINE.
A pumping mechanism that duplicates the output, rate, and blood pressure of the natural heart. It may replace the function of the entire heart or a portion of it, and may be an intracorporeal, extracorporeal, or paracorporeal heart. (Dorland, 28th ed)
A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.
The application of engineering principles and methods to living organisms or biological systems.
A type of scanning probe microscopy in which a probe systematically rides across the surface of a sample being scanned in a raster pattern. The vertical position is recorded as a spring attached to the probe rises and falls in response to peaks and valleys on the surface. These deflections produce a topographic map of the sample.
Devices, not affixed to the body, designed to help persons having musculoskeletal or neuromuscular disabilities to perform activities involving movement.
A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
Examination of the mouth and teeth toward the identification and diagnosis of intraoral disease or manifestation of non-oral conditions.
Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
The joint that is formed by the inferior articular and malleolar articular surfaces of the TIBIA; the malleolar articular surface of the FIBULA; and the medial malleolar, lateral malleolar, and superior surfaces of the TALUS.
A dental specialty concerned with the histology, physiology, and pathology of the tissues that support, attach, and surround the teeth, and of the treatment and prevention of disease affecting these tissues.
Replacement of the ANKLE JOINT.
The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.
The medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders.
Services offered to the library user. They include reference and circulation.
The study of the heart, its physiology, and its functions.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.
The scientific disciplines concerned with the embryology, anatomy, physiology, biochemistry, pharmacology, etc., of the nervous system.
... the biophysical mechanisms underlying migration at the level of cells and tissues; biomimetic systems for cell-based assays; ... Samuel Sánchez Ordóñez Bacterial infections: antimicrobial therapies Dr. Eduart Torrents Integrative cell and tissue dynamics ... "Integrative cell and tissue dynamics". Institute for Bioengineering of Catalonia. Retrieved 2021-04-26. "Synthetic, Perceptive ... Bioengineering for Regenerative Therapies: Molecular dynamics at the interface of cells and biomaterials; ...
Kabu, S.; Gao, Y.; Kwon, B.K.; Labhasetwar, V. (2015). "Drug delivery, cell-based therapies, and tissue engineering approaches ... In humans with non-injured tissues, the tissue is naturally regenerated over time; by default these tissues have new cells ... 2014). "Humans iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration". ... It has been shown that bone marrow-derived cells could be the source of progenitor cells of multiple cell lineages, and a 2004 ...
Kabu S, Gao Y, Kwon BK, Labhasetwar V (December 2015). "Drug delivery, cell-based therapies, and tissue engineering approaches ... Types of cells being researched for use in SCI include embryonic stem cells, neural stem cells, mesenchymal stem cells, ... olfactory ensheathing cells, Schwann cells, activated macrophages, and induced pluripotent stem cells. Hundreds of stem cell ... "Cell Therapy Augments Functional Recovery Subsequent to Spinal Cord Injury under Experimental Conditions". Stem Cells ...
Kabu, S.; Gao, Y.; Kwon, B.K.; Labhasetwar, V. (2015). "Drug delivery, cell-based therapies, and tissue engineering approaches ... Stem cells are cells that can differentiate to become different types of cells. The hope is that stem cells transplanted into ... Types of cells being researched for use in SCI include embryonic stem cells, neural stem cells, mesenchymal stem cells, ... "Hydrogels and Cell Based Therapies in Spinal Cord Injury Regeneration". Stem Cells International. 2015: 1-24. doi:10.1155/2015/ ...
These include blood and blood products, vaccines, allergenics, cell and tissue-based products, and gene therapy products. New ... Districts are based roughly on the geographic divisions of the Federal court system. Each district comprises a main district ... The most rigorous requirements apply to new molecular entities: drugs that are not based on existing medications. New drugs ... This guidance distinguishes the apps subjected to regulation based on the marketing claims of the apps. Incorporation of the ...
Designed to be applied broadly, the original definition includes cell and stem cell therapies, gene therapy, tissue engineering ... an overview of their potential in cell-based therapy". Expert Opinion on Biological Therapy. 15 (9): 1293-306. doi:10.1517/ ... Examples include the injection of stem cells or progenitor cells obtained through directed differentiation (cell therapies); ... When the cell source for a regenerated organ is derived from the patient's own tissue or cells, the challenge of organ ...
The company develops, produces and markets cell-based tools for life science, tissue engineering, drug discovery and cosmetics ... The company's research and development focus lies in the fields of cell immune therapy and adult stem cell therapy. 3H ... vectors for genetic modification and cell-based assays. "3H Biomedical AB". Archived from the original on 2011-10-07. Retrieved ... The company started out marketing and selling primary cells, and has since extended its portfolio with cell chips, RNA, DNA, ...
Topics covered include neural stem cells, neural tissue engineering, gene therapy, and minimally-invasive treatment of ... evidence-based case reports, and perspectives. The journal is abstracted and indexed in BIOSIS Previews, Chemical Abstracts, ... Neural Regeneration Research is a peer-reviewed scientific journal covering research on neuroregeneration and stem cells. ...
... which allows the selective destruction of cancer cells without any damage to normal tissues. It is a light-based cancer therapy ... Based on the current hypothesis, cell death induced by PIT was caused by rapid expansion of local water upon the formation of ... "Immunological responses triggered by photothermal therapy with carbon nanotubes in combination with anti-CTLA-4 therapy to ... Conventional photodynamic therapy (PDT) uses a non-specific photosensitizer which can be activated by a non-ionizing light to ...
Linear accelerator-based therapies[edit]. Main article: Megavoltage X-rays. A linear accelerator (linac) produces x-rays from ... resulting in the cell's death. Thus, biological inactivation is carried out in a volume of tissue to be treated, with a precise ... Proton beam therapy[edit]. Main article: Proton therapy. Protons may also be used in radiosurgery in a procedure called Proton ... Gamma Knife therapy, like all radiosurgery, uses doses of radiation to kill cancer cells and shrink tumors, delivered precisely ...
Koshiol J, Lin SW (July 2012). "Can tissue-based immune markers be used for studying the natural history of cancer?". review. ... Cancer Biology & Therapy. 6 (7): 1143-7. doi:10.4161/cbt.6.7.4704. PMID 17630503. Slattery ML, Herrick J, Curtin K, Samowitz W ... by means of molecular pathology or surrogate histopathology or immunohistochemistry analysis of diseased tissues and cells ... Typically, MPE utilizes tissue pathology resources and data within existing epidemiology studies. Molecular epidemiology ...
is a late stage cell therapy company developing autologous cell therapies from adipose tissue to treat a variety of medical ... Cytori Therapeutics, Inc., of the United States, is a pharmaceutical company, based in San Diego. The company develops and ... This cell therapy product is prepared from a patient's own adipose (fat) tissue using the company's fully automated Celution® ... The system formulates a cell therapy product that is available for delivery to the patient within 1-2 hours of tissue ...
"Cryopreservation and Cell Banking for Autologous Mesenchymal Stem Cell-Based Therapies". Cell & Tissue Transplantation & ... thus preserving the cell line, which is especially useful when the cell line has a limited number of cell divisions. Cells can ... They often contain expansive amounts of base cell material that can be utilized for various projects. Cell banks can be used to ... Utilizing cell banks also reduces the cost of cell culture processes, providing a cost-efficient alternative to keeping cells ...
"Microencapsulated stem cells for tissue repairing: implications in cell-based myocardial therapy". Regen Med. 4 (5): 733-45. ... An emerging approach to answer the problems related to ischemic tissue repair is through the use of stem cell-based therapy. ... research is the use of stem cells such as mesenchymal stem cells for long term cell microencapsulation and cell therapy ... xenogeneic cells). The use of autologous cells in microencapsulation therapy is limited by the availability of these cells and ...
... "based on genes, cells, or tissue engineering",[8] including gene therapy medicines, somatic-cell therapy medicines, tissue- ... somatic cells, gene therapies, tissues, recombinant therapeutic protein, and living cells used in cell therapy. Biologics can ... mammalian cell lines (see cell culture) and plant cell cultures (see plant tissue culture) and moss plants in bioreactors of ... Many vaccines are grown in tissue cultures. Gene therapy[edit]. Viral gene therapy involves artificially manipulating a virus ...
Of the four types, mRNA-based therapy is the only type which is based on triggering synthesis of proteins within cells, making ... whole cells, and even specific tissues. Examples of RNA aptamer molecular targets and potential targets include vascular ... doi:10.1016/j.cell.2009.01.002. PMC 3794896. PMID 19167326. Zhu G, Chen X (September 2018). "Aptamer-based targeted therapy". ... February 2012). "mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients". ...
These tissue-resident NK cells share transcriptional similarity to tissue-resident memory T cells described previously. However ... NK cell receptors can also be differentiated based on function. Natural cytotoxicity receptors directly induce apoptosis (cell ... preventing this therapy from being used in combination with monoclonal antibody therapies. NK-92 cells were derived from a ... NK cells are thought to be an important cell type in this process. These cells are known as "uterine NK cells" (uNK cells) and ...
"Hierarchical scaffold design for mesenchymal stem cell-based gene therapy of hemophilia B." Current Opinion in Chemical Biology ... these cell types include osteoblasts (bone cells), adipocytes (fat cells), and chondrocytes (cartilage cells). Ligament tissue ... Stem cell treatment[edit]. Autologous stem-cell transplantation using mesenchymal stem cells (MSCs) has been used to improve ... Ligament cells differ in size, respond to different cues in the cell environment, and express different cell surface markers, ...
Bacelieri R, Johnson SM (2005). "Cutaneous warts: an evidence-based approach to therapy". Am Fam Physician. 72 (4): 647-52. ... Salicylic acid, the treatment of warts by keratolysis, involves the peeling away of dead surface skin cells with keratolytic ... destroying the live tissue. Electrodesiccation and surgical excision may produce scarring. Laser surgery is generally a last ... An evidence-based approach to therapy". American Family Physician. 72 (4): 647-652. PMID 16127954. "Laser Surgery for Warts", ...
Placon Therapeutics is developing platinum-based cancer therapies. These include BTP-114, the first clinical candidate to use ... with the goal of targeting cancerous tissue and leaving healthy cells alone. Its proprietary drug candidates included BTP-114, ... He has made major contributions in a number of areas, including the development of platinum-based anticancer drugs such as the ... Rosenberg, B.; Van Camp, L.; Krigas, T. (1965). "Inhibition of Cell Division in Escherichia coli by Electrolysis Products from ...
It differs in pathology from GME by more tissue breakdown and increased eosinophils (white blood cells). CSF analysis is also ... Definitive diagnosis is based on histopathology, either a brain biopsy or post-mortem evaluation (necropsy). A CT scan or MRI ... There is evidence that treatment with radiation therapy for focal GME provides the longest periods of remission. Pug Dog ... The blood vessels of the posterior segment of the eye and anterior uvea have the same infiltrates of inflammatory cells as the ...
... mast cell tumor). It can be administered in different treatment schemes, such as induction therapy, adjuvant, neoadjuvant, ... mast cell tumor, osteosarcomas, soft tissue sarcoma), feline cancers (mammary carcinomas, hemangiosarcomas, lymphomas, ... Oncovet C (Chemovet S.A.), is the is the first-based drug approved in Latin America for veterinary use for canine and feline ... Suggested mechanisms include: Elimination of T regulatory cells (CD4+CD25+ T cells) in naive and tumor-bearing hosts Induction ...
The diagnosis may be suspected based on symptoms and MRI and confirmed by tissue biopsy. Blood tests may show anaemia, and less ... Diagnosis is confirmed by tissue biopsy. Treatment may involve surgery, chemotherapy, radiation therapy, and certain medicines ... In 1973, Christian Nezelof recognised the abnormal cell as a 'Langerhans-like' cell, however it took another ten years for the ... The mutations causes white blood cells (lymphocytes, macrophages, and eosinophils) to move towards dendritic cells, resulting ...
... they could provide an ideal source of pluripotent stem cells for regenerative medicine and cell-based therapy. Currently, Life ... "Muse Cells Provide the Pluripotency of Mesenchymal Stem Cells: Direct Contribution of Muse Cells to Tissue Regeneration". Cell ... Other than mesenchymal tissues, Muse cells locate in connective tissue of every organ and in the peripheral blood. Muse cells ... Muse cells act as tissue repairing cells in vivo. When systemically administrated, naive Muse cells (without cytokine treatment ...
Diagnosis is suspected based on physical examination and confirmed by tissue biopsy. Routine screening is not recommended. ... These lesions originate from epidermal squamous cells, the most common type of skin cell. Carcinoma-in-situ is a precursor ... Standard treatments may include surgery, radiation therapy, chemotherapy, and biologic therapy. Vulvar cancer newly affected ... Most vulvar cancers are squamous cell cancers. Other types include adenocarcinoma, melanoma, sarcoma, and basal cell carcinoma ...
MiRNA-based therapies are under investigation. The first miRNA was discovered in 1993 by a group led by Ambros and including ... miRNA research revealed different sets of miRNAs expressed in different cell types and tissues and multiple roles for miRNAs in ... and cell cycle in mice lacking miRNA-1-2". Cell. 129 (2): 303-17. doi:10.1016/j.cell.2007.03.030. PMID 17397913. Thum T, ... B-cell migration/adhesion, cell-cell interactions in immune niches and the production and class-switching of immunoglobulins. ...
The diagnosis is based on tissue examination, e.g. biopsy. Under the microscope, glassy cell carcinoma tumours are composed of ... Advanced tumours are treated with surgery (radical hysterectomy and bilateral salpingo-opherectomy), radiation therapy and ... Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour of the uterine cervix. ... 2004). "Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature". ...
More recently hyperthermia therapy uses microwaves to heat tissue to kill cancer cells. However, as detailed below, the ... In Europe, the use of the ISM band is covered by Short Range Device regulations issued by European Commission, based on ... the standards on which almost all wireless systems are based, use the ISM bands. Virtually all laptops, tablet computers, ...
Christoforou, N; Gearhart, JD (May-June 2007). "Stem cells and their potential in cell-based cardiac therapies". Progress in ... Pluripotent stem cells, i.e. cells that can give rise to any fetal or adult cell type, can be found in a number of tissues, ... Intestinal stem cells reside near the base of the stem cell niche, called the crypts of Lieberkuhn. Intestinal stem cells are ... "Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis". ...
... and cell-based therapy. The process of introducing foreign DNA into eukaryotic cells is known as transfection. Electroporation ... When the electricity applied to the tissue is above the electric field threshold of the target tissue, the cells become ... or other molecule that is not normally permeable to the cell membrane) into the cell. Not all tissue has the same electric ... "Electrofusion of mesenchymal stem cells and islet cells for diabetes therapy: a rat model". PLOS ONE. 8 (5): e64499. Bibcode: ...
Photoelectric cells in a spectrophotometer device worn on the forehead measure the amount of each wavelength of light reflected ... Neurofeedback, a specific form of biofeedback, is based on the idea that human beings can consciously alter their brain ... Mize, W. (2004). Hemoencephalography-a new therapy for attention deficit hyperactivity disorder (ADHD): case report. Journal of ... which are responsible for the transport and transference of oxygen to tissue throughout the body, must increase the amount of ...
The molecular bases of beta cell mass reduction in type 2 diabetes". Seminars in Cell and Developmental Biology. doi:10.1016/j. ... "An Evidence-Based Medicine Approach to Antihyperglycemic Therapy in Diabetes Mellitus to Overcome Overtreatment". Circulation. ... and fat tissue.[51] In the liver, insulin normally suppresses glucose release. However, in the setting of insulin resistance, ... a type 2 diabetic will have lost about half of their beta cells.[52] Fatty acids in the beta cells activate FOXO1, resulting in ...
Mice lacking plakoglobin have cell adhesion defects in many tissues, although β-catenin substitutes for plakoglobin at many ... Recently, there have been a number of studies in the lab and in the clinic investigating new possible therapies for cancers ... but much more work is needed before an adequate treatment based on this concept can be determined. Lab studies have also ... F9 embryonal carcinoma cells are similar to the P19 cells shown in Figure 1 and normally have cell-to-cell adhesion mediated by ...
... amino acid therapy may be helpful for regenerating damaged or atrophied muscle tissue. The branched-chain amino acids or BCAAs ... Based upon a meta-analysis of seven randomized controlled trials that was published in 2015, HMB supplementation has efficacy ... "satellite cells" which help to regenerate skeletal muscle fibers, and a decrease in sensitivity to or the availability of ... A CT scan can distinguish muscle tissue from other tissues and thereby estimate the amount of muscle tissue in the body. Fast ...
... cannot exit from the cell. This results in intense radiolabeling of tissues with high glucose uptake, such as the normal brain ... Statistical, likelihood-based approaches: Statistical, likelihood-based [37][38] iterative expectation-maximization algorithms ... PET has an expanding role as a method to assess the response to therapy, in particular, cancer therapy,[57] where the risk to ... based regularization in a wavelet or other domain), such as via Ulf Grenander's Sieve estimator[41][42] or via Bayes penalty ...
... dendritic cells and other cells including liver cells, fibroblasts, and adrenal gland cells.[93] Viral replication triggers ... Developments in organ-on-a-chip technology have led to a chip-based model for Ebola haemorrhagic syndrome.[262] ... "Experimental therapies: growing interest in the use of whole blood or plasma from recovered Ebola patients (convalescent ... Hazelton's veterinary pathologist sent tissue samples from dead animals to the United States Army Medical Research Institute of ...
"A Review of hormone-based therapies to treat adult acne vulgaris in women". International Journal of Women's Dermatology. 3 (1 ... and Th1 cells.[45] IL-1α stimulates increased skin cell activity and reproduction, which, in turn, fuels comedo development.[45 ... the follicle can break into the deeper layers of the dermis and subcutaneous tissue and cause the formation of deep nodules.[1] ... Combination therapy[edit]. Combination therapy-using medications of different classes together, each with a different mechanism ...
... stem cells, white blood cells) in many tissues and organs. SP amplifies or excites most cellular processes.[15][16] ... Muñoz M, Rosso M, Coveñas R (Jun 2011). "The NK-1 receptor: a new target in cancer therapy". Current Drug Targets. 12 (6): 909- ... the peptide based NK1RA) against cisplatin-induced emesis in the ferret.[75] It is likely that some peripheral exposure ... Cell growth, proliferation, angiogenesis, and migrationEdit. The above processes are part and parcel to tissue integrity and ...
As of 2013[update], there were at least two commercialized allogeneic cell therapies, Prochymal and Cartistem.[25] ... It is an attack by the "new" bone marrow's immune cells against the recipient's tissues. This can occur even if the donor and ... In addition, a genetic mismatch as small as a single DNA base pair is significant so perfect matches require knowledge of the ... who have lost their stem cells after birth. Other conditions[13] treated with stem cell transplants include sickle-cell disease ...
... therapy should be continued during pregnancy.[20] Furthermore, therapy should be immediately administered to women diagnosed ... Grapefruit juice may delay the absorption of levothyroxine, but based on a study of 10 healthy people aged 20-30 (8 men, 2 ... T4 and T3 bind to thyroid receptor proteins in the cell nucleus and cause metabolic effects through the control of DNA ... Mandel SJ, Brent GA, Larsen PR (September 1993). "Levothyroxine therapy in patients with thyroid disease". Annals of Internal ...
"Stem-cell therapy shows promise for horse soft-tissue injury, disease". DVM Newsmagazine. Vaadatud 2013-10-21. ... "Biocell Center Corporation Partners with New England's Largest Community-Based Hospital Network to Offer a Unique... - MEDFORD ... Lindvall O (2003). "Stem cells for cell therapy in Parkinson's disease". Pharmacol Res 47 (4): 279-87. PMID 12644384. ... Wu DC, Boyd AS, Wood KJ (2007). "Embryonic stem cell transplantation: potential applicability in cell replacement therapy and ...
... or prescribe pharmaceutical drugs or other therapies. Differential diagnosis methods help to rule out conditions based on the ... Histology is the study of the structures of biological tissues by light microscopy, electron microscopy and ... discovered by Paul Ehrlich in 1908 after he observed that bacteria took up toxic dyes that human cells did not. The first major ... "know the best course for", from PIE base *med- "to measure, limit. Cf. Greek medos "counsel, plan", Avestan vi-mad "physician" ...
It has received regulatory approval for use as a treatment for non-small cell lung cancer,[6][4][7][8] although there is ... February 2015). "Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and ... and is currently the preferred EGFR-TKI therapy for exon 18 mutations (particularly G719x).[17][verification needed] ... Connective tissue growth factor (CTGF). *Ephrins (A1, A2, A3, A4, A5, B1, B2, B3) ...
Biopsy and confirmation of Borrelia cells in myocardial tissue may be used in specific cases but are usually not done because ... Bianchi GE (1950). "[Penicillin therapy of lymphocytoma]" [Penicillin therapy of lymphocytoma]. Dermatologica (in German). 100 ... Cases have been reported as far east as the island of Newfoundland.[105][214][215][216] A model-based prediction by Leighton et ... The spirochetes may also induce host cells to secrete quinolinic acid, which stimulates the NMDA receptor on nerve cells, which ...
Potassium is the major cation (positive ion) inside animal cells,[223] while sodium is the major cation outside animal cells.[ ... organolithium compounds are extremely powerful bases and nucleophiles. For use as bases, butyllithiums are often used and are ... Sartori, H. E. (1984). "Cesium therapy in cancer patients". Pharmacol Biochem Behav. 21 (Suppl 1): 11-13. doi:10.1016/0091-3057 ... organ changes and tissue accumulation". Journal of Environmental Science and Health, Part A. 16 (5): 549-567. doi:10.1080/ ...
"Tissue Antigens. 64 (5): 575-80. doi:10.1111/j.1399-0039.2004.00310.x. PMID 15496200.. ... In 1975, association with "HL-A1,8" (Current name: HLA A1-B8) was confirmed by serological typing of cells from myasthenics.[11 ... Rocca P, Codes L, Chevallier M, Trépo C, Zoulim F (November 2004). "[Autoimmunization induced by interferon alpha therapy in ... June 2004). "Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic ...
Radiation therapyEdit. The goal of radiation therapy is to kill tumor cells while leaving normal brain tissue unharmed. In ... The decision to prescribe this treatment is based on a patient's overall health, type of tumor, and extent of the cancer. The ... Experimental treatments include targeted therapy, gamma knife radiosurgery,[45] boron neutron capture therapy and gene therapy. ... Anaplastic cells have lost total control of their normal functions and many have deteriorated cell structures. Anaplastic cells ...
Speech therapy Cardiovascular complications. Mitral valve dysfunction, congestive heart failure. Most severe. Common. Premature ... Molecular genetic testing on a blood specimen or cells from a cheek swab is available to identify mutations in the RSK2 gene. ... In 2002, Helen Fryssira and RJ Simensen identified a 3 base pair deletion in the gene encoding RSK2, which was the first report ... Skin and related tissue. *Dyskeratosis congenita. *Hypohidrotic ectodermal dysplasia (EDA). *X-linked ichthyosis ...
... and is produced in a tissue-selective manner based on expression of 5α-reductase.[111] Tissues in which DHT forms at a high ... Katsambas AD, Dessinioti C (2010). "Hormonal therapy for acne: why not as first line therapy? facts and controversies". Clin. ... stimulating cell division and tissue growth.[13] In accordance, therapeutic modalities that reduce androgen signaling in the ... See also: Management of prostate cancer § Hormonal therapy, and Androgen deprivation therapy ...
Intravenous interferon therapy has also been used.[citation needed] When Lassa fever infects pregnant women late in their third ... Other laboratory findings in Lassa fever include lymphocytopenia (low white blood cell count), thrombocytopenia (low platelets ... Diagnosis based on symptoms is difficult.[1] Confirmation is by laboratory testing to detect the virus's RNA, antibodies for ... This is because the virus has an affinity for the placenta and other highly vascular tissues. The fetus has only a one in ten ...
... pus cells in the urine (pyuria) or cancer cells in the urine. A 24-hour urine collection can be used to quantify daily protein ... of a core biopsy needle into the kidney to obtain a small sample of kidney tissue. The kidney tissue is then examined under a ... Nearly all programs train nephrologists in continuous renal replacement therapy; fewer than half in the United States train in ... is a national organization that represents and supports the independent and community-based dialysis providers. The American ...
This stem-based definition is equivalent to the more common definition of Sauropsida, which Modesto and Anderson synonymized ... Morphological and cellular aspects of tail and limb regeneration in lizards a model system with implications for tissue ... "Theraputic potential of snake venom in cancer therapy: current perspective". Asian Pacific Journal of Tropical Medicine. 3 (2 ... Cell. 25 (4): 326-328. doi:10.1016/j.devcel.2013.05.011. PMID 23725759.. ...
Newer vaccines, based on vero cells, are in development and should replace 17D at some point.[4] ... A French team developed the French neurotropic vaccine (FNV), which was extracted from mouse brain tissue. Since this vaccine ... it had been previously discounted as a possible therapy.[103] Infection was reduced in mosquitoes with the wMel strain of ... The viruses infect, amongst others, monocytes, macrophages, and dendritic cells. They attach to the cell surfaces via specific ...
Further in the future, stem cell biotechnology may also make this possible, with no need for anti-rejection drugs. ... Monstrey, S.; Vercruysse Jr., H.; De Cuypere, G. (2009). "Is Gender Reassignment Surgery Evidence Based? Recommendation for the ... After sex reassignment surgery, transsexuals (people who underwent cross-sex hormone therapy and sex reassignment surgery) tend ... non-penile inversion techniques that make use of scrotal tissue to construct the vaginal canal. For trans men, genital ...
Most patients with hyper IgE syndrome are treated with long-term antibiotic therapy to prevent staphylococcal infections. Good ... and DOCK8-hyper-IgE syndromes differ in IgE-based sensitization pattern". Allergy. 69: 943-953. doi:10.1111/all.12416. ISSN ... balloon-like lesions that may be filled with air or pus or scar tissue) and very high concentrations of the serum antibody IgE ... T cell deficiency. (T). *thymic hypoplasia: hypoparathyroid (Di George's syndrome). *euparathyroid (Nezelof syndrome ...
"Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture". Cell. 157 ... Gottschlich, Michele M. (2001). The Science and Practice of Nutrition Support: A Case-based Core Curriculum. Kendall Hunt. p. ... Schlenker, Eleanor; Gilbert, Joyce Ann (28 August 2014). Williams' Essentials of Nutrition and Diet Therapy. Elsevier Health ... doi:10.1016/j.cell.2014.05.009. PMC 4144415 . PMID 24906154.. *^ Anke M. Arsenic. In: Mertz W. ed., Trace elements in human and ...
Adipose Tissue And Adipokines in Health And Disease (Nutrition and Health). Totowa, NJ: Humana Press. 2006: 222. ISBN 1-58829- ... Science-Based Solutions to Obesity: What are the Roles of Academia, Government, Industry, and Health Care? Proceedings of a ... Expert review of cardiovascular therapy (Review). 2011-03, 9 (3): 265-77. PMID 21438803. doi:10.1586/erc.10.22.. ... Cell (Review). 2004, 116 (2): 337-50. PMID 14744442. doi:10.1016/S0092-8674(03)01081-X.. ...
2008). "Hand Transplantation: The Innsbruck Experience". Transplantation of Composite Tissue Allografts. pp. 234-250. doi: ... On January 13, 2015, doctors at the Kochi-based Amrita Institute of Medical Sciences and Research Centre (AIMS) successfully ... After the transplant, there is a period of extensive hand therapy/rehabilitation which helps the recipients regain function of ... Those patients who are dedicated to taking the medications and performing the physical therapy following a hand transplant have ...
Cancer therapy[edit]. Pharmaceutical companies have been designing cancer therapy drugs to target DNA in traditional methods ... The CAAT box is located about 75-80 bases upstream of the transcription initiation site and about 150 bases upstream of the ... "Molecular Cell. 68 (1): 130-143.e5. doi:10.1016/j.molcel.2017.08.016. PMC 5632562. PMID 28918903.. ... "Polymorphisms in the 5' regulatory region of the tissue factor gene and the risk of myocardial infarction and venous ...
... or re-grow cartilage tissue to replace missing or damaged cartilage. One cell-based replacement technique is called autologous ... Then these cells are injected into the patient. These cells are held in place by a small piece of soft tissue from the tibia, ... The cells grow in self-organized spheroid matrices which are implanted via injected fluid or inserted tissue matrix. For years ... An advantage to this approach is that a person's own stem cells are used, avoiding tissue rejection by the patient's immune ...
Submissions should focus on focusing on new diagnostic and surgical techniques, instrument and therapy updates, as well as ... many options involving cell therapy mainly based on retinal and iris pigment epithelium cells as well as stem cells are being ... Current Treatment Limitations in Age-Related Macular Degeneration and Future Approaches Based on Cell Therapy and Tissue ... 2Tissue Engineering and Biomaterials Unit, CEIT and TECNUN (University of Navarra), Paseo de Manuel Lardizabal 15, 20018 San ...
... Med Biol Eng ... The principal biochemical and biological characteristics of the collagen-based biomaterials are presented, including their ... interactions with cells (fibroblasts), distinct from those of synthetic polymers, and their potential use in gene therapy ... With the rapid development in tissue engineering, these different biomaterials have been used as three-dimensional scaffolds ...
Current Stem Cell Research & Therapy. Title: Mesenchymal Stem Cell-Based HLA-Independent Cell Therapy for Tissue Engineering of ... Mesenchymal Stem Cell-Based HLA-Independent Cell Therapy for Tissue Engineering of Bone and Cartilage. Author(s): Philipp ... Keywords: Mesenchymal Stem Cells, HLA-antigen, Tissue Engineering, bone regeneration, cartilage repair ... Keywords:Mesenchymal Stem Cells, HLA-antigen, Tissue Engineering, bone regeneration, cartilage repair ...
... of fat tissue are a particularly attractive option for cell based therapy given their accessibility and relative abundance. ... The objective of this study was to determine whether SVF cells sorted based on expression of alkaline phosphatase liver/bone/ ... Cells positive for ALPL expression (ALPL+) represented approximately 34% of the gated population, while cells negative for ALPL ... Cells were separated into positive and negative groups using fluorescence-activated cell sorting (FACS) then differentiated ...
Cell-based therapy in the repair of osteochondral defects: A novel use for adipose tissue. Tissue Engineering 9 (4) : 733-744. ... Cell-based therapy in the repair of osteochondral defects: A novel use for adipose tissue. ...
... and Tissue-Based Therapy" by people in this website by year, and whether "Cell- and Tissue-Based Therapy" was a major or minor ... Cell- and Tissue-Based Therapy*Cell- and Tissue-Based Therapy. *Cell and Tissue Based Therapy ... "Cell- and Tissue-Based Therapy" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Cell- and Tissue-Based Therapy" by people in Profiles. ...
... in the fields of biomaterial and medical sciences constitutes a challenge for the development of effective therapies in humans ... Stem cells (SCs) are a unique cell type capable of self‐renewal and reconstructing damaged tissues. At the present time, adult ... are already used as implants to replace or improve the functionality of the damaged tissue or organ. However, the continuous ... Biomaterial sciences and tissue engineering approaches are currently fundamental strategies for the development of regenerative ...
Here, we show that human adipose tissue-derived mesenchymal stem cells (ADSCs) secrete exosomes carrying enzymatically active ... Of note, ADSC-derived exosomes were transferred into N2a cells and were suggested to decrease both secreted and intracellular A ... Importantly, these characteristics were more pronounced in ADSCs than bone marrow-derived mesenchymal stem cells, suggesting ... Accordingly, there is growing evidence that MSC-based therapies could benefit a wide range of neurodegenerative diseases12, ...
... their potential for cell-based therapy].. Together they form a unique fingerprint. * Cell- and Tissue-Based Therapy Medicine ... Tissue repairing cells that exist among mesenchymal stem cells; their potential for cell-based therapy]. / Dezawa, Mari. ... Tissue repairing cells that exist among mesenchymal stem cells; their potential for cell-based therapy]. In: Nihon rinsho. ... Tissue repairing cells that exist among mesenchymal stem cells; their potential for cell-based therapy]. Nihon rinsho. Japanese ...
 Areas of interest will be established and emerging concepts in stem cell research.Indexed on:American Chemical Societys ... Cardiac tissue engineering and regeneration using cell-based therapy Alrefai MT, Murali D, Paul A, Ridwan KM, Connell JM, Shum- ... Human adipose stem cell and ASC-derived cardiac progenitor cellular therapy improves outcomes in a murine model of myocardial ... Mesenchymal stem cell therapy for osteoarthritis: current perspectives Wyles CC, Houdek MT, Behfar A, Sierra RJ ...
Cell-based regenerative therapy has the potential to correct bone tissue injuries. by buyresearchchemicalss, May 30, 2019. Cell ... Mesenchymal stem cells (MSCs) are an appealing autologous way to obtain somatic stem cells for cell-based bone tissue ... 1. Launch Cell-based regenerative therapy gets the potential to correct harmed or defect-containing bone tissue thats ... Right here, we built multilayered mesenchymal cell (MLMCs) sheet anchored to collagen-binding bFGF utilizing a book cell tissue ...
Cell-and Tissue-based Therapy; Tissue Engineering; Wounds and Injuries. PMID:. 24616577. PMCID:. PMC3945123. DOI:. 10.3346/jkms ... Cell therapy has also been developed for chronic wound healing. By transplanting cells with an excellent wound healing capacity ... Cell therapy for wound healing.. You HJ1, Han SK1.. Author information. 1. Department of Plastic Surgery, Korea University ... The purpose of this review is to provide information on clinically available cell-based treatment options for healing of acute ...
... potential of human mesenchymal stem cells from adipose tissue and hamstring tendons for musculoskeletal cell-based therapy. ... potential of human mesenchymal stem cells from adipose tissue and hamstring tendons for musculoskeletal cell-based therapy, ... potential of human mesenchymal stem cells from adipose tissue and hamstring tendons for musculoskeletal cell-based therapy. ... potential of human mesenchymal stem cells from adipose tissue and hamstring tendons for musculoskeletal cell-based therapy. / ...
Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells. ... Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells ... we are hopeful that chronic diseases amenable to SVF cell therapy or ASC therapy will also be identified. ... Adipose tissue is now recognized as an accessible, abundant, and reliable site for the isolation of. adult stem cells suitable ...
Scaffolds for Cell and Tissue Engineering.. Semiconductor-Based Implantable Prosthetic Devices.. Sensor Biocompatibility and ... Autologous Platelet-Based Therapies.. Back-Propagation.. Batteries for Implantable Biomedical Applications.. Bayesian Analysis. ... a comprehensive knowledge base for existing and future research. It will be a useful reference on our bookshelves...the editors ... knowledge base. To represent the vast diversity of the field and its multi-and cross-disciplinary nature and serve the BME ...
The therapeutic potential of mesenchymal stem cells. Cell- & tissue-based therapy PICINICH S. C. ... Thus, periodontal ligament cells might be useful for the regeneration of alveolar bone in tissue engineering applications. ... Paravascular cells in endosteal spaces of alveolar bone contribute to periodontal ligament cell populations MCCULLOCH CAG ... Although several periodontal regeneration therapies have been devised, the origin of the undifferentiated cells that regenerate ...
Cellular-based Therapy for Cartilage Regeneration - focus on Tissue Specific Stem/Progenitor Cells. 20 May 2020 ...
... is a CC chemokine that is selective in its recruitment of naive T cells and dendritic cells (DCs). In the lymph node, SLC is ... believed to play an important role in the initiation of an immune response by colocalizing naive T cells with DC-presenting ... T cell-dependent antitumor immunity mediated by secondary lymphoid tissue chemokine: augmentation of dendritic cell-based ... Genetic Therapy * Immunity, Cellular / drug effects * Immunity, Cellular / immunology * Immunotherapy, Adoptive * Injections, ...
Tissue Engineering and Cell-Based Therapy in Regenerative Medicine. Banerjee, Ena Ray ... based, nutraceutical-based, functional-food-based and antibody-based green therapy designed tackle multifaceted diseases and ... and cells (tissue engineering of stem cells of embryonic origin, adult tissue origin and umbilical cord-derived) in ... The book discusses topics such as tissue engineering to create lineage-specific cells for tissue-specific regeneration; how ...
From animal models to clinical trials, MSCs have afforded promise in the treatment of numerous diseases, mainly tissue injury ... the major stem cells for cell therapy, have been used in the clinic for approximately 10 years. ... and provide an overview of mechanisms that are significant in MSC-mediated therapies. Although MSCs for cell therapy have been ... In this review, we summarize the recent opinions on methods, timing and cell sources for MSC administration in clinical ...
Cell therapies for the central nervous system remain an untapped market due to the complexity involved in growing neural ... Cell therapies for the central nervous system remain an untapped market due to the complexity involved in growing neural ... Designing tissue constructs for the discovery of better drug treatments are also limited due to the resolution needed for an ... Designing tissue constructs for the discovery of better drug treatments are also limited due to the resolution needed for an ...
Stem Cell-Based Therapies for Liver Diseases: An Overview and Update Stem Cell-Based Therapies for Liver Diseases: An Overview ... cell-based therapies for liver diseases as well as the current challenges and future expectations for a successful cell-based ... Stem cell-based therapy could be a promising therapeutic method for patients with end-stage liver disease, which may alleviate ... induced pluripotent stem cells, liver stem cells, mesenchymal stem cells, and hematopoietic stem cells. In vitro and in vivo ...
2001) Multilineage cells from human adipose tissue: Implications for cell-based therapies. Tissue Eng 7:211-228. ... Another aspect of this study is the higher efficiency of the gene therapy strategy by including the use of tissue-specific cell ... 2005) Novel autologous cell therapy in ischemic limb disease through growth factors secretion by cultured adipose tissue- ... Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: A combined gene therapy-cell transplantation ...
Medical Xpress) -- Researchers at Columbia Engineering have established a new method to patch a damaged heart using a tissue- ... engineering platform that enables heart tissue to repair itself. This breakthrough, recently published ... ... DeNeRD: an AI-based method to process whole images of the brain. Oct 17, 2019 ... Citation: Biomedical engineers patch a heart using novel tissue cell therapy (2011, May 6) retrieved 20 October 2019 from https ...
Hyaluronic acid based tissue engineering (modified therapy, biomaterial, scaffold and stem cells). Hyaluronic acid serves as a ... Bowman, S., Awad, M.E., Hamrick, M.W. et al. Recent advances in hyaluronic acid based therapy for osteoarthritis. Clin Trans ... Based on the study of 76 trials by Bellamy et al. locally injected HA treatment is an effective treatment for OA based on its ... Recent advances in hyaluronic acid based therapy for osteoarthritis. *Steven Bowman1 na1, ...
Medical Xpress is a web-based medical and health news service that features the most comprehensive coverage in the fields of ... Phase III clinical trials for stem cell-based cartilage regeneration therapy have started. A group of researchers at Osaka ... Related topics: cells · embryonic stem cells Cancer Rare melanoma type highly responsive to immunotherapy. Desmoplastic ... Mount Sinai researchers have discovered that normal immune cells called macrophages, which reside in healthy breast tissue ...
2 cell therapy products; gene therapy products; allergenic extracts; or human cells, tissues, and cellular and tissue based ... Gallen University to study relevant data-based performance metrics which may be useful in predicting risks to quality prior to ... Help the FDA develop compliance and inspection policies and practices, and inform risk-based scheduling of drug manufacturing ... "Measuring Pharmaceutical Quality through Manufacturing Metrics and Risk-Based Assessment," Engelberg Center for Health Care ...
"Cell-Based Therapies and Tissue Engineering", running from May 19 through May 20, 2021. ... Cancer Center leadership will review abstracts based on the relationship to cancer, novelty, significance of findings and ... Though this event is happening virtually, attendees will experience the conference using Whova, our official web-based ... He was selected for his work into how a genetic variant enables prostate cancer cells to evade first-line treatment and leads ...
The hype is well-earned because of the potential of stem cells to contribute to disease modeling, drug screening, and even ... The hype is well-earned because of the potential of stem cells to contribute to disease modeling, drug screening, and even ... In this review, we focus on neural differentiation of these cells and their biomedical applications. We compare the various ... In this review, we focus on neural differentiation of these cells and their biomedical applications. We compare the various ...
... the sensory epithelium repairs to close the lesions but no new hair cells arise and hearing impairment ensues. For any cell ... Following the loss of hair cells from the mammalian cochlea, ... Cell Differentiation. Cell- and Tissue-Based Therapy / methods ... inner hair cell; Dc = Deiters cell, ip = inner pillar cell, op = outer pillar cell, Hc = Hensens cell, Cc = Claudius cell, Bc ... cells in the repaired organ of Corti following hair cell loss may be a consideration for the use of stem cell-based therapies ...
  • Mesenchymal stem cells (MSC) can be obtained from human bone marrow aspirates and, thanks to their differentiation potential and excellent in vitro culture properties, represent an attractive cell line for the regeneration of mesenchymal tissue. (
  • Regenerative medicine represents a new interdisciplinary field of clinical science focused on the development and implementation of novel strategies to enhance the process of regeneration of impaired cells, tissues and organs as well as replacing damaged cells with new, fully functional cells of the required phenotype [ 1 , 2 ]. (
  • To improve the effectiveness of such regeneration processes, one of the potential approaches is application of stem cell (SC)‐based therapy. (
  • In addition, the combination of stem cells with biocompatible materials that may constitute a scaffold for the seeded cells may lead to enforcement of biological activity of stem cells and as such accelerate the process of regeneration or restoration of impaired tissue [ 3 , 4 ]. (
  • The exogenous program of growth elements, particularly simple fibroblast growth aspect (bFGF), has been proven to promote tissues regeneration when executing bone tissue grafting [14C17]. (
  • Regeneration of periodontal tissues, lost as a result of periodontal disease, is a key objective of periodontal treatment. (
  • Although several periodontal regeneration therapies have been devised, the origin of the undifferentiated cells that regenerate periodontal tissues remains unknown. (
  • Therefore, in the present study, to clarify the existence of osteoblast progenitor cells in the periodontal ligament, as well as to investigate the mechanism of alveolar bone regeneration without any effects from the original bone, we evaluated osteoblast differentiation induced by transplantation of GFP-transgenic rat molars into the subcutaneous tissues of wild-type rats. (
  • Thus, periodontal ligament cells might be useful for the regeneration of alveolar bone in tissue engineering applications. (
  • Several cell types have been investigated for liver regeneration, such as embryonic stem cells, induced pluripotent stem cells, liver stem cells, mesenchymal stem cells, and hematopoietic stem cells. (
  • In vitro and in vivo studies have demonstrated that stem cells are promising cell sources for the liver regeneration. (
  • By enabling regeneration and replacement of our damaged tissues, we can help people live longer and better. (
  • CONCLUSIONS/SIGNIFICANCE: The lack of dedifferentiation amongst supporting cells and their replacement by cells from the outer side of the organ of Corti are factors that may need to be considered in any attempt to promote endogenous hair cell regeneration. (
  • Research in the MPPB department covers a very broad range, including both basic and applied science, and topics such as cell signaling, biomedical engineering, neuroscience, drug and gene delivery, tissue regeneration, structural biology, sensory transduction, physiology and cell biology. (
  • Regeneration in humans is the regrowth of lost tissues or organs in response to injury. (
  • Some tissues such as skin and large organs including the liver regrow quite readily, while others have been thought to have little or no capacity for regeneration. (
  • However ongoing research, particularly in the heart and lungs, suggests that there is hope for a variety of tissues and organs to eventually become regeneration-capable. (
  • In 2008, in full thickness wounds over 3mm, it was found that a wound needed a material inserted in order to induce full tissue regeneration. (
  • Advances in research have enabled the induced regeneration of many more tissues and organs than previously thought possible. (
  • By 2009, via the use of materials, a max induced regeneration could be achieved inside a 1 cm tissue rupture. (
  • In 2009, the regeneration of hollow organs and tissues with a long diffusion distance, was a little more challenging. (
  • The microenvironment of neuron cells plays a crucial role in regulating neural development and regeneration. (
  • The purpose of this research was to assess the effect of HA biomaterial combining with PC12 cells conditioned media (PC12 CM) in neural regeneration. (
  • In this study, we focused on the characterization and possibility of mineralized tissue regeneration using SHED. (
  • Journal Article] Regulation of the Wnt signaling pathways during cell culture of human mesenchymal stem cells for efficient bone regeneration. (
  • Journal Article] Promising cell-based therapy for bone regeneration using stem cells from deciduous teeth, dental pulp, and bone marrow. (
  • Journal Article] A feasibility of useful cell-based therapy by bone regeneration with deciduous tooth stem cells, dental pulp stem cells, or bone marrow-derived mesenchymal stem cells for clinical study using tissue engineering technology. (
  • Cells play a pivotal role in the repair and regeneration of the bone tissue in vitro and in vivo. (
  • A comparison of bone regeneration with human mesenchymal stem cells and muscle-derived stem cells and the critical role of BMP. (
  • The potential of stem-cell based technologies hold promise for the repair, restoration and regeneration of dysfunctional cells in the eye, yet significant challenges remain. (
  • Stem cells hold great potential as cell-based therapies to promote vascularization and tissue regeneration. (
  • Controlled angiogenesis is an important component of successful tissue regeneration ( 1 ) as well as the treatment of ischemic diseases. (
  • These limitations motivate the need for more consistent and reproducible source material for tissue regeneration," says Dr. McDevitt, who conducted the research while he was a professor at the Georgia Institute of Technology. (
  • Advances in our understanding of mechanisms of cell death, plasticity and regeneration in the central nervous system offer new opportunities for remediation and repair in several of the most distressing neurodegenerative diseases of adulthood, in particular Parkinson's and Huntington's disease. (
  • 2 ) Considering the several disadvantages of heart transplantation, which is still the best option for patients with end-stage heart failure, ( 3 ) and the restricted regenerative abilities of cardiomyocytes to heal the heart after an acute acute myocardial infarction, ( 4 ) many studies in regenerative medicine have been performed creating alternatives for myocardial regeneration through tissue engineering. (
  • Advances in tissue engineering are evident, and the application of this technology to the regeneration of myocardium has been increasingly explored, and presented encouraging results. (
  • This review briefly presents the most widely used techniques in cardiac tissue engineering spanning two decades: from the late 1990s, when this tissue engineering application saw its first studies, to nowadays, when grafts with a broad potential for cardiac regeneration are sought. (
  • The approach usually taken into account is since biomaterials are able to positively interact with biological systems, they should then seek to improve the regeneration of the damaged tissue or effectively replacing it. (
  • In the Editorial 'Surgical Therapies and Tissue Regeneration: At the Intersection Between Innovation and Regulation,' the Clinical Council of the Editorial Board of Tissue Engineering discuss the United States Code of Federal Regulations as it relates to the use of human cells and tissues and the products derived from them (HCT/Ps). (
  • At Duke University, Kenneth Poss, professor of cell biology, and director of the Regeneration Next initiative, was the senior investigator for a study of spinal cord regeneration in zebra fish. (
  • In my lab, we are researching genetic factors that enable regeneration of tissues such as heart and spinal in nonmammalian animals like zebra fish," Poss told Healthline. (
  • A scientist in my lab, Mayssa Mokalled, led a study finding that a gene called connective tissue growth factor [CTGF] is important for spinal cord regeneration in zebra fish after an injury that completely severs the cord. (
  • CTGF is necessary to stimulate cells called glia to form a tissue bridge across the severed parts of the spinal cord - an early step in spinal cord regeneration. (
  • I think it has gotten worse because now it's becoming more mainstream," said Arnold R. Kriegstein, MD, PhD, director of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research in the department of neurology at the University of California, San Francisco. (
  • Here, our goal was to identify the specific cell type responsible for the improved cardiac regeneration and to restore that capacity in aged individuals after myocardial infarction (MI). (
  • Post-natal tissues have reservoirs of specific stem cells which contribute to maintenance and regeneration. (
  • We have here reviewed the medical literature describing molecular and functional characterization, differentiation, potential role, and results obtained so far using ADSCs in tissue repair, with a particular focus on the role for ADSCs in cardiovascular repair and regeneration. (
  • For tissue regeneration therapy on the other hand, the in vivo life of some cytokines are limited to hours or even minutes after injection, far from sufficient to exert biological functions in vivo . (
  • The Institute for Bioengineering of Catalonia (IBEC) is an institution engaged in basic and applied research in bioengineering and nanomedicine, with experts working on tissue regeneration, biomechanics, molecular dynamics, biomimetics, drug delivery, organs 'on-a-chip', cell migration, stem cells, artificial olfaction and microbial biotechnology. (
  • Stem and progenitor cells constitute another promising cell source, however, their reproducible differentiation into pancreatic cells presents significant challenges. (
  • Multilineage differentiation of alkaline phosphatase liver/bone/kidney-sorted stromal vascular fraction cells. (
  • As MSCs comprise heterogeneous cell populations, however, the cells responsible for wide-ranging differentiation as well as for tissue repair have not been identified. (
  • Tendon stem/progenitor cells showed lower adipogenic and osteogenic ability, but after the chondrogenic differentiation, they produced more abundant glycosaminoglycans and expressed higher levels of aggrecan with regards to ASCs. (
  • The past decade has witnessed an explosion of preclinical data relating to the isolation, characterization, cryopreservation, differentiation, and transplantation of freshly isolated stromal vascular fraction cells and adherent, culture- expanded, adipose-derived stromal/stem cells in vitroand in animal models. (
  • Cell therapies for the central nervous system remain an untapped market due to the complexity involved in growing neural tissues, controlling their differentiation, and protecting them from the hostile environment they meet upon implantation. (
  • Efforts to induce vascular growth into tissue-engineered scaffolds have recently been dedicated to developing novel strategies to deliver specific biological factors that direct the recruitment of endothelial cell (EC) progenitors and their differentiation. (
  • In this review, we focus first on neural differentiation of these cells. (
  • Significant progress has been made in culture and differentiation protocols to obtain cells suitable for transplantation. (
  • There was no evidence of significant de-differentiation of the specialised columnar supporting cells. (
  • Specifically, his team is studying the role of micro-RNA as it relates to chronic inflammation and stem cell differentiation in the development and perpetuation of chronic tendinopathy. (
  • Thus, this review provides an overview of the available biomaterials for directing stem cell differentiation as a means of producing replacements for diseased or damaged tissues. (
  • The differentiation potential of stem cells makes them a valuable tool for such applications. (
  • Such biomaterial scaffolds promote the viability and differentiation of stem cells seeded inside depending on the intrinsic properties of the material as well as the incorporation of specific chemical and physical cues into the material. (
  • Nukbone® promotes proliferation and osteoblastic differentiation of mesenchymal stem cells from human amniotic membrane. (
  • They are focusing on the derivation and differentiation of human embryonic stem cells under GMP conditions. (
  • Stem cells are characterized by their self-renewal ability and differentiation potential ( 1 ) and can be divided into embryonic and adult stem cells. (
  • Stem cells and cancer stem cells share certain features such as self-renewal and differentiation potential. (
  • For adipogenic differentiation, cells were cultured in MEM plus 10% FCS, 0.5 mmol/L 3-isobutyl-1-methylxanthine, 0.5 mmol/L hydrocortisone, 1 mmol/L dexamethasone, 200 mmol/L indomethacin, and 50 μg/mL gentamicin for 2 weeks. (
  • The differentiation potential was related to the tissue of origin. (
  • It was concluded from the results that Leu might prevent the emigration of rBMCs to the outside of the scaffold and promote the differentiation of cells to osteoblasts in the scaffold. (
  • Recently, there have been reports indicating that MSCs secrete a variety of factors that promote tissue repair, stimulate proliferation and differentiation of endogenous tissue progenitors, and decrease inflammatory and immune reactions [ 24 - 26 ]. (
  • With the rapid development in tissue engineering, these different biomaterials have been used as three-dimensional scaffolds and cell transplant devices. (
  • The principal biochemical and biological characteristics of the collagen-based biomaterials are presented, including their interactions with cells (fibroblasts), distinct from those of synthetic polymers, and their potential use in gene therapy through the formation of neo-organs or organoids. (
  • Biomaterials, such as ceramics and metals, are already used as implants to replace or improve the functionality of the damaged tissue or organ. (
  • Moreover, biomaterials may enhance the SCs biological activity and their implementation by establishing a specific microenvironment mimicking natural cell niche. (
  • Thus, the synergistic advancement in the fields of biomaterial and medical sciences constitutes a challenge for the development of effective therapies in humans including combined applications of novel biomaterials and SCs populations. (
  • Adhesion of Cells to Biomaterials. (
  • Developing biomaterials scaffolds and drug delivery systems for tissue engineering and regenerative medicine. (
  • A wide range of natural and synthetic biomaterials have been evaluated as substrates for controlling stem cell behavior. (
  • Next, specific examples will be discussed for the three major categories of biomaterials: natural, synthetic, and ceramic-based. (
  • Currently, a large number of differentiated (somatic) and undifferentiated (stem) cells have been used for bone reconstruction alone or in combination with different biomaterials and constructs (e.g., scaffolds). (
  • Biomaterials have been the focus of materials for use in tissue engineering, as traditional biomaterials or development of tissue engineering-specific variants. (
  • While the operating room is often the stage where innovations in tissue engineering and regenerative medicine are realized, as surgeons use grafted tissues, novel biomaterials, and new approaches to perform breast, chest and abdominal wall, and pelvic floor reconstruction, new FDA draft guidelines would place even tighter restrictions on surgical practice and may limit the development of new therapies. (
  • Plasma-based biomaterials for the treatment of cutaneous radiation injury. (
  • and biomaterials for regenerative therapies. (
  • This study compares for the first time human tendon stem/progenitor cells isolated from hamstring tendons with human ASCs. (
  • In this review, we briefly introduce various adult stem cells implemented in bone tissue engineering such as mesenchymal stem cells (including bone marrow- and adipose-derived stem cells), endothelial progenitor cells, and induced pluripotent stem cells. (
  • BM Sca-1+ cells that homed to the heart in aged recipients proliferated and stimulated the propagation of host aged progenitor cells post-MI. (
  • The number of BM-derived Sca-1+ progenitor cells in the aged myocardium was the major determinant for successful cardiac functional recovery. (
  • Experimental studies have shown that cardiac transfer of unfractionated or partially purified bone marrow cells, as well as stem cells and progenitor cells derived from the bone marrow or peripheral blood, can enhance functional recovery after an acute myocardial infarction. (
  • Numerous studies have provided evidence that stromal cells derived from the adipose tissue (adipose tissue-derived stromal cells [ADSCs]) contain a population of adult multipotent mesenchymal stem cells and endothelial progenitor cells that can differentiate into several lineages, including endothelial cells, smooth muscle cells, and cardiomyocytes. (
  • 1 Transplantation of stem or progenitor cells is a promising strategy for cardiac repair, attracting tremendous attention of basic scientists and clinicians. (
  • We refer here to the term adipose tissue-derived stromal cells (ADSCs), which identifies a plastic-adherent cell population that includes vascular (pericytes and endothelial progenitor cells)/adipocyte progenitor cells (preadipocytes) and adult multipotent mesenchymal stem cells (MSCs), besides circulating blood cells, fibroblasts, endothelial cells, smooth muscle cells, and immune cells, such as macrophages and lymphocytes 27 ( Figure 1 ). (
  • BioTime's lead cell delivery clinical program, Renevia®, which consists of our proprietary HyStem® cell-transplantation delivery matrix combined with the patient's own adipose progenitor cells (Fat), met its primary endpoint in an EU pivotal clinical trial for the treatment of facial lipoatrophy in HIV patients in 2017. (
  • Moreover, tissue engineering strategies to design and manufacture scaffolds to mimic Bruch's membrane are very diverse and under investigation. (
  • Cultured on three-dimensional scaffolds according to the tissue engineering concept, they have already been successfully employed for reconstruction of mesenchymal tissues in numerous studies involving both small and large animal models. (
  • The utility of this approach was evaluated by using 3D poly(lactide-co-glycolide) (PLAGA) sintered microsphere scaffolds for bone tissue engineering applications. (
  • In this approach, the neotissue can be constructed by using a combination of specific cells, growth factors, and 3D porous scaffolds alone or in combination ( 3 ). (
  • The success of tissue engineering strategies, however, critically depends on the extent of blood vessel infiltration into the scaffolds ( 4 ). (
  • The primary function of vasculature is to facilitate the transport of nutrients and oxygen to cells invading from the host tissue and cells transplanted in the scaffolds. (
  • Combining stem cells with biomaterial scaffolds serves as a promising strategy for engineering tissues for both in vitro and in vivo applications. (
  • This updated review details commonly used biomaterial scaffolds for engineering tissues from stem cells. (
  • Tissue engineering combines biomaterial scaffolds with these different types of cells to replace damaged organs. (
  • The advantages and drawbacks of each material type will be detailed along with relevant examples of how such scaffolds can influence stem cell behavior. (
  • This review focuses on three-dimensional (3D) scaffolds as they mimic the environment found in the human body, making them highly relevant when engineering tissues, including the use of 3D printing tissues using biomaterial-based inks. (
  • S.c. implantation of scaffolds seeded with VEGF-expressing stem cells (hMSCs and hESdCs) led to 2- to 4-fold-higher vessel densities 2 weeks after implantation, compared with control cells or cells transfected with VEGF by using Lipofectamine 2000, a leading commercial reagent. (
  • One approach to alleviate this demand is to reconstruct kidneys using tissue engineering scaffolds. (
  • Murine embryonic stem cells were seeded into the decellularized scaffolds and cultured up to 14 days with one of three protocols: whole scaffold, perfused scaffold, and sectioned scaffold culture. (
  • Other challenges include scale-up of manufacturing processes and use of appropriate tissue scaffolds and bioreactors for the creation of 3-D models. (
  • The main approach of this scientific field is the creation of scaffolds, which contain cells that can be applied as cardiac grafts in the body, to have the desired recovery. (
  • Bioengineers along with biologists, nanotechnologists, physicians and other specialties are working upon connecting tissues and potential organs or scaffolds made of biological materials to resemble cartilage, bone and other structure that supports tissue and organ growth. (
  • Yabuuchi, T. , Yoshikawa, M. , Kakigi, H. and Hayashi, H. (2014) Hybrid Scaffolds Composed of Amino-Acid Coated Sponge and Hydroxyapatite for Hard Tissue Formation by Bone Marrow Cells. (
  • Herath, H.M., Di Silvio, L. and Evans, J.R. (2010) Biological Evaluation of Solid Free Formed, Hard Tissue Scaffolds for Orthopedic Applications. (
  • Both in vitro and in vivo , they can differentiate into cartilage, bone, tendons and fat cells, and-in contrast to embryonic stem cells-they are not under ethical scrutiny. (
  • Stem cells (SCs) are a unique type of cells characterized by the ability to (i) self‐renewal through unlimited cell divisions and (ii) differentiate into other types of specialized cells, including epithelial, muscle, neuronal cells and others [ 5 , 6 ]. (
  • Although adult stem cells are generally known to generate the cell types of the tissue in which they reside, mesenchymal stem cells (MSCs) are unique in that they differentiate not only into the same mesodermal-lineage such as bone, cartilage, and adipocytes, but also into other lineages of ectodermal and endodermal cells. (
  • Furthermore, a subpopulation of MSCs are known to integrate into damaged sites, differentiate into cell types specific to the integrated tissue and contribute to the tissue repair. (
  • Recent evidence suggests that a subpopulation of human MSCs, which were named Muse cells, were shown to have the ability to differentiate into trilineage cells and to function as tissue repairing cells in vivo. (
  • Mesenchymal stem cells (MSCs) are an appealing autologous way to obtain somatic stem cells for cell-based bone tissue regenerative therapy, because they proliferate in vitro and differentiate into bone tissue cells [1C5] actively. (
  • They can differentiate into various specialized cell types under certain physiological or experimental conditions. (
  • Stem cells are undifferentiated cells that can differentiate into a variety of cell types. (
  • To promote biomaterial vascularization, a number of strategies have been developed by using ( i ) growth factors that induce endothelial cell (EC) migration and proliferation ( 9 ⇓ - 11 ) and ( ii ) ECs or stem cells that can differentiate toward the endothelial lineage ( 12 , 13 ). (
  • They filled the scaffold with human mesenchymal progenitors (stem cells that can differentiate into many cell types) and then applied the patches to damaged heart tissue . (
  • A highly useful feature of Muse cells is their specific ability to detect damage signals, which allows them to migrate toward and home into damaged tissues when infused into the peripheral blood stream where they can spontaneously differentiate into cells compatible with the homed-into tissue. (
  • Stem cells are different from other cells of the body in that they have the ability to differentiate into other cell/tissue types. (
  • Examining the ability of these cells to proliferate and differentiate in a whole kidney extracellular matrix scaffold would serve as a valuable baseline for future studies in producing a functioning organ. (
  • they have the potential to give rise to an entire organism and to differentiate to all cell lineages ( 2 ). (
  • MSC are multipotent cells with many potential clinical applications due to their capacity to be expanded ex vivo and to differentiate into several lineages, including osteocytes, chondrocytes, myocytes, and adipocytes. (
  • Although adipose tissue-derived MSCs and bone marrow-derived MSCs (BMMSCs) show the same immunoregulatory functions and support of hematopoiesis [ 36 ], BMMSCs have a higher degree of commitment to differentiate into chondrogenic and osteogenic lineages than adipose tissue-derived MSCs [ 37 ]. (
  • About Cord Blood Association: The Cord Blood Association will be an international nonprofit organization that promotes the banking and use of umbilical cord blood and related tissues for disease treatment and regenerative therapies. (
  • The ISSCR supports the increase in biomedical research funding in the 21st Century Cures Act in the U.S. It also underscores concern that the bill's streamlined process for FDA review and approval of regenerative therapies include a rigorous review of scientific and clinical evidence to ensure safety and efficacy. (
  • The scientific and technological research at the institute is grouped into three core application areas: Bioengineering for Regenerative Therapies, Bioengineering for Future Medicine and Bioengineering for Active Ageing. (
  • One of our major findings is that the murine peritoneal environment, where encapsulated cells are commonly transplanted, is hypoxic and it becomes more hypoxic upon transplantation of islets or other insulin-secreting cells. (
  • Results from experiments involving transplantation of murine, insulin-secreting L cells in diabetic mice demonstrated that the graft had a significant positive effect on the glycemic regulation of the animals, however, it did not cure diabetes. (
  • On the basis of the available literature, MSC have to be referred to as immune privileged, and they seem to be available for HLA-independent cell transplantation. (
  • Therapies that involve the TRANSPLANTATION of CELLS or TISSUES developed for the purpose of restoring the function of diseased or dysfunctional cells or tissues. (
  • Alpha-SMA- and BMP4-positive cells were observed near the root surface at 5 days after transplantation. (
  • Stem cell-based therapy could be a promising therapeutic method for patients with end-stage liver disease, which may alleviate the need for liver transplantation in the future. (
  • Another approach is transplantation of retinal pigment epithelium cells derived from either human embryonic stem cells or from the patient's own induced pluripotent stem cells. (
  • However, the use of stem cells alone to promote angiogenesis remains limited because of insufficient expression of angiogenic factors and low cell viability after transplantation. (
  • Genetic modification of MSCs with Akt or Bcl-2 gene also improved the therapeutic efficacy of cell transplantation in treating myocardium ( 11 , 12 ). (
  • At present, the only method to cure corneal endothelial dysfunction is by transplantation of a cadaver donor cornea with normal corneal endothelial cells. (
  • The first successful treatment for mucopolysaccharidoses was bone marrow transplantation, which was introduced for the therapy in 1980. (
  • Hematopoietic stem cell transplantation (HSCT) has been used in patients with mucopolysaccharidosis in order to correct the enzyme-deficiency. (
  • Intra-bone marrow bone marrow transplantation (IBM-BMT) can replace not only hemopoietic stem cells (HSCs) but also MSCs. (
  • Safety and Role of Gastrointestinal Endoscopy in the Management of Gastrointestinal Acute GVHD in Children After Hematopoietic Stem Cell Transplantation. (
  • Safety of ruxolitinib therapy prior to allogeneic hematopoietic stem-cell transplantation for myeloproliferative neoplasms. (
  • In the presence of just four genes (identified because they are highly expressed by embryonic stem cells), they can assume the characteristics of embryonic stem cells and, under the right conditions, can become nearly any cell type. (
  • Pluripotent, embryonic stem cells originate as inner cell mass (ICM) cells within a blastocyst. (
  • However, one advantage of EG cells is that they do not appear to generate tumours when transferred into the body, as embryonic stem cells do. (
  • Stem cells can be derived from several sources, including embryonic stem cells, fetal stem cells, hematopoietic stem cells, mesenchymal stem cells, adult stem cells and induced pluripotent stem cells. (
  • Pluripotent embryonic stem cells are highly proliferative, capable of differentiating into all cells of the kidney, and respond to tissue-specific extracellular matrix proteins. (
  • Geron focuses on human embryonic stem cells (hESCs). (
  • Some current methods generate embryonic stem cells using a fertilized egg. (
  • 2 Several issues have been raised against harvesting human embryonic stem cells. (
  • 3 Compared with embryonic stem cells, autologous adult stem cells do not raise any major ethical or immunologic problems. (
  • Human pluripotent stem cells (hPSCs) represent a new and exciting field in modern medicine, now the focus of many researchers and media outlets. (
  • We discovered non-tumorigenic pluripotent stem cells, Multilineage differentiating Stress Enduring (Muse) cells, that reside in the bone marrow and adipose tissue, and are collectable as SSEA-3(+) cells. (
  • In particular, the discovery of induced pluripotent stem cells (iPSCs) in 2006 catalyzed the fields of tissue engineering and regenerative medicine as they represented a major advance in stem cell technology [ 4 ]. (
  • Now researchers at the Stanford University School of Medicine have devised an efficient and safer way to make these induced pluripotent stem cells, or iPS cells, by using just the proteins that the genes encode. (
  • As a renewable resource that is both scalable and consistent in manufacturing, pluripotent stem cells are an ideal solution. (
  • 2021. Induced pluripotent stem cells derived from the developing striatum as a potential donor source for cell replacement therapy for Huntington disease . (
  • Adipose tissue is now recognized as an accessible, abundant, and reliable site for the isolation of adult stem cells suitable for tissue engineering and regenerative medicine applications. (
  • Chapter 1 from Translational Approaches in Tissue Engineering and Regenerative Medicine,Jeremy J. Mao, Gordana Vunjak-Novakovic, Antonios G. Mikos, Anthony Atala, Editors Publisher: Artech House Publishers Illustration: N Language: ENG Title: Tis. (
  • Non-pancreatic cells from the same patient (autologous), targeted by gene transfer vectors or retrieved surgically and genetically engineered ex vivo before being returned to the patient, may relax the immune acceptance problems but pose challenges regarding the amount and kinetics of insulin secretion in response to physiologic stimuli. (
  • However, even though cell-accumulation technique order Vitexin has been evaluated in vitro with murine fibroblasts, the potential of this operational system to market bone repair in vivo is not investigated with MSCs. (
  • The properties and bone tissue formation capacity of the material had been examined both in vitro and in vivo utilizing a rat femur model. (
  • Cells or tissues might be unmanipulated, or their biological characteristics can be altered ex vivo before administration of the final product to patients. (
  • Generally humans, in vivo, can regenerate injured tissues for limited distances of up to 2mm. (
  • Questions remain about optimal delivery methods, host immune responses, in vivo monitoring, long-term adhesion, function and survival of cells, and adverse effects. (
  • Virally modified, VEGF-overexpressing mesenchymal stem cells (MSCs) were reported to enhance angiogenesis ( 1 ) in vivo and improve myocardial function ( 10 ). (
  • Here, we developed biodegradable polymer-DNA nanoparticles to engineer stem cells to efficiently express angiogenic factors for the purpose of promoting angiogenesis in vivo. (
  • For human ex vivo tissue and cell culture processing applications. (
  • However, human corneal endothelial cells are notorious for their limited proliferative capability in vivo and are therefore prone to corneal endothelial dysfunction that eventually may lead to blindness. (
  • Here we show that although they can be managed safely during the standard ex vivo expansion period (6-8 weeks), human mesenchymal stem cells can undergo spontaneous transformation following long-term in vitro culture (4-5 months). (
  • Mesenchymal stem cells (MSCs) are multipotent cells which can give rise to mesenchymal and non-mesenchymal tissues in vitro and in vivo. (
  • The second strategy may be less accurate to study MSC natural distribution in vivo because the cells might engraft nonspecifically in different locations. (
  • For instance, bone marrow aspiration may yield low numbers of stem cells on processing, which necessitates an ex vivo expansion step to obtain sufficient cell numbers for clinical application. (
  • Coating the nanoparticle surface with cancer cell recognizing ligands is expected to facilitate specific delivery of nanoparticles to diseased cells in vivo. (
  • A critical problem in protein therapy is that most protein drugs are currently administered by frequent injections due to their tissue impermeability and short in vivo life. (
  • To achieve in vivo or in situ sustained-release of protein drugs, various polymer-based formulation strategies have been examined since 1970s ( 2 - 10 ). (
  • ES cells can give rise to almost all cell lineages and are the most promising cells for regenerative medicine. (
  • cell lineages characterizes MSCs as pluripotent cells, suggesting that the term `mesenchymal' stem cell might be inappropriate to describe this particular stem cell. (
  • Right here, we built multilayered mesenchymal cell (MLMCs) sheet anchored to collagen-binding bFGF utilizing a book cell tissue anatomist technique. (
  • Based on the origin and source of isolation, SCs may be included in two main groups: (i) embryonic SCs (ESCs)-derived from embryos at different stages of development and (ii) adult SCs (ASCs)-isolated from several postnatal and adult tissue sources, including the umbilical cord, cord blood, bone marrow, adipose tissue, central nervous system, retina, skeletal muscle and other mature tissues [ 7 , 8 ]. (
  • Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood. (
  • GenCure's stem cells come exclusively from donated umbilical cord blood and adult donors. (
  • Its subsidiaries - the South Texas Blood & Tissue Center, QualTex Laboratories, GenCure and The Blood & Tissue Center Foundation - provide products used in regenerative medicine treatment and research, including cellular therapies, umbilical cord blood and tissue services, as well as testing of blood and plasma products for clients in the United States and worldwide. (
  • MSCs can be isolated from different adult tissues including bone marrow (BM), umbilical cord, skeletal muscle and adipose tissue . (
  • Hematopoietic stem cells (HSCs) have been widely used for allogeneic cell therapy. (
  • MSCs, also called mesenchymal stromal cells, are a subset of non-hematopoietic adult stem cells that originate from the mesoderm. (
  • Marker Found that Enables Segregation of True Human Hematopoietic Stem Cells. (
  • The Program's lead product candidate in this area is NBS10, a chemotactic hematopoietic stem cell product comprised of autologous bone marrow-derived CD34/CXCR4 cells selected to treat damaged heart muscle following AMI (severe heart attack). (
  • Differentiated cells such as hematopoietic cells ( 2 ) and myoblasts ( 3 ) have been shown to induce vessel formation in limb or myocardial ischemic model by expressing angiogenic factors. (
  • The progressive increases of corrected versus non-corrected peripheral blood leukocytes indicate the potential of RP-L102 to restore the functionality of bone marrow hematopoietic stem cells. (
  • Safety of Living Donation of Hematopoietic Stem Cells. (
  • For example, when companies use primary adult stem cells, costs can be huge. (
  • Human adult stem cells are being evaluated widely for various therapeutic approaches. (
  • The clear similarities between stem cell and cancer stem cell genetic programs are nonetheless the basis of a recent proposal that some cancer stem cells could derive from human adult stem cells. (
  • This is the first report of spontaneous transformation of human adult stem cells, supporting the hypothesis of cancer stem cell origin. (
  • Mesenchymal stem cells (MSCs) are prototypical adult stem cells, identified as an adherent, fibroblast-like population positive for CD105, CD90 and CD73, and lacking hematopietic markers. (
  • Broadly speaking," states Thomas B. Okarma, Ph.D., M.D., president, CEO, and director of Geron (, "the cost of goods is among the most critical issues for biomanufacturing cellular therapies. (
  • Recently, bFGF-PKD-CBD was proven to enhance bone tissue formation at lower concentrations than bFGF alone when order Vitexin packed onto implantable collagen bed sheets [28, 29], recommending that the procedure mix of bFGF-PKD-CBD and a multilayered cell build comprising MSCs may promote ectopic bone tissue formation at defect sites. (
  • Mesenchymal stem cells (MSCs), the major stem cells for cell therapy, have been used in the clinic for approximately 10 years. (
  • From animal models to clinical trials, MSCs have afforded promise in the treatment of numerous diseases, mainly tissue injury and immune disorders. (
  • Although MSCs for cell therapy have been shown to be safe and effective, there are still challenges that need to be tackled before their wide application in the clinic. (
  • Due to the limitation of using ES and iPS cells in the clinic, great interest has developed in mesenchymal stem cells (MSCs), which are free of both ethical concerns and teratoma formation. (
  • MSCs exist in almost all tissues. (
  • A group of researchers at Osaka University developed a synthetic tissue using synovium-derived mesenchymal stem cells (MSCs) for treating damaged cartilage, which had previously been incurable and had no effective therapies. (
  • The systematic isolation of MSCs from different organs and tissues and the evaluation of their characteristics could represent an alternative approach. (
  • MSCs have been shown to modulate immunological responses via T-cell suppression [ 24 , 26 - 28 ]. (
  • Adipose tissue and BM are the most readily available sources of MSCs because they are easy to harvest, and because of their relative abundance of progenitors and the lack of ethical concerns. (
  • Since 2016, FDA has been working on a collaborative research project with St. Gallen University to study relevant data-based performance metrics which may be useful in predicting risks to quality prior to failure. (
  • In 2016 scientists could transform a skin cell into any other tissue type via the use of drugs. (
  • The article is available free for download on the Tissue Engineering website until July 1, 2016. (
  • Dissertation: Cartilage tissue engineering for auricular reconstruction. (
  • MSC have been isolated from bone marrow, cartilage, and adipose tissue and all show similar morphologic and phenotypic characteristics ( 3 ). (
  • These results indicate that periodontal ligament tissue remaining on the root surface after a tooth extraction contains undifferentiated cells that have the ability to regenerate alveolar bone. (
  • There are some human organs and tissues that regenerate rather than simply scar, as a result of injury. (
  • The aim for these techniques is to be used in the near future to regenerate any tissue in the human body. (
  • Therefore, to regenerate hollow organs and tissues with a long diffusion distance, the tissue had to be regenerated inside the lab, via the use of a 3D printer. (
  • Next, they mined the essential factors produced by the cells that send the signal to regenerate new tissue. (
  • The goals of this emerging field are to replace, repair, or regenerate tissues and organs. (
  • It is an interdisciplinary field combining many techniques that aim to maintain, regenerate or replace a tissue or organ. (
  • Tissue engineering is a set of biomedical, biotechnological and engineering techniques that aim to maintain, regenerate or replace tissues or organs. (
  • 2019. Designing stem-cell-based dopamine cell replacement trials for Parkinson's disease . (
  • The application of ASCs and SVF cells is still in its infancy and the field has made progressive advances towards clinical applications. (
  • For each of these research domains, we will describe recent advances in hPSCs culture and we will focus on the clinical relevance of using hPSCs for in vitro nervous system disease modeling and therapies. (
  • peer-reviewed publications were screened for relevance in order to identify key advances in stem and progenitor cell contribution to the field of bone tissue engineering. (
  • As the field of regenerative medicine endeavors to harness the body's own cells for treatment, scientific innovation has led to great advances in stem cell-based therapies in the past decade. (
  • Recent advances in cell therapies and tissue engineering are paving the road to regenerative medicine. (
  • In this review, we summarize the advances in understanding the behavior of human corneal endothelial cells, their current engineering strategy in vitro and their potential applications. (
  • Fibroblasts, keratinocytes, adipose-derived stromal vascular fraction cells, bone marrow stem cells, and platelets have been used for wound healing in clinical practice. (
  • Reconstruction using stromal vascular fraction (SVF) cells. (
  • 7 The majority of treatments at these clinics use adipose-derived stem cells, known as a stromal vascular fraction (SVF) product. (
  • Tissue fragments are then incubated with collagenase and the digest is centrifuged, separating the floating population of mature adipocytes from the pelleted stromal vascular fraction (SVF). (
  • The potential and challenges for developing clinical therapies based on these approaches will be discussed. (
  • Biomaterial sciences and tissue engineering approaches are currently fundamental strategies for the development of regenerative medicine. (
  • One of the fundamental principles underlying tissue engineering approaches is that newly formed tissue must maintain sufficient vascularization to support its growth. (
  • The hype is well-earned because of the potential of stem cells to contribute to disease modeling, drug screening, and even therapeutic approaches. (
  • New approaches to engineering tissues, such as 3D bioprinting, are described as they provide exciting opportunities for future work along with current challenges that must be addressed. (
  • 2 Trials of stem cell therapy have taken several approaches. (
  • To investigate the subject further, we generated long-term cultures of cells with mesenchymal stem cell characteristics from different organs and tissues from adult mice. (
  • function to damaged cells, organs and tissues. (
  • Nanomaterials for T-cell cancer immunotherapy. (
  • Differential modulation of this key immunoinhibitory molecule in tumor versus normal tissues may advance both cell-mediated immunotherapy and antibody-based targeted strategies using the B7-H3-specific mAb 8H9. (
  • Regenerative medicine market is segmented into cell therapy, gene therapy, tissue engineering and immunotherapy, based on therapy. (
  • Can human ASCs and SVF cell implants cause tumors either directly through transformation or indirectly by promoting the growth of endogenous tumor cells? (
  • Intratumoral injections of SLC inhibited tumor growth in a CD8+, T cell-dependent manner. (
  • SLC elicited a substantial infiltration of DCs and T cells into the tumor, coincident with the antitumor response. (
  • The adoptive transfer of T cells has emerged as a promising treatment strategy for cancer, but improvements on enhanced longevity and infiltration to tumor tissue, particularly in solid tumors, are needed. (
  • Whereas B7-H3 transcript was ubiquitously expressed in a wide spectrum of human solid tumors as well as human normal tissues, B7-H3 protein was preferentially expressed only in tumor tissues. (
  • B7-H3 protein expression was inversely correlated with miR-29 levels in both cell lines and tumor tissues tested. (
  • Human B7-H3 (also named as CD276) is a member of the B7/CD28 immunoglobulin superfamily, which provides crucial costimulatory signals that regulate T-cell functions in tumor surveillance, infections, and autoimmune diseases ( 1 ). (
  • Moreover, tumor B7-H3 expression was correlated with patient poor survival in both clear cell renal cell carcinoma and urothelial cell carcinoma ( 9 , 10 ). (
  • Cancer stem cells (CSCs) exhibit mesenchymal stem cell (MSC) features and represent a subpopulation of tumor cells that play an important role in tumor progression, chemotherapy resistance, recurrence and metastasis. (
  • Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are cancer cells that display distinctive features of normal stem cells and that have the ability to give origin to all cell types of a particular cancer sample. (
  • The new method improves on older therapies by providing a sustainable source for fresh tissue and reducing the risk of tumor formation that can arise with stem cell transplants. (
  • Journal Article] Carbon 11-labeled methionine positron emission tomography for detection of residual viable tumor cells after adjuvant. (
  • HCT/Ps from donors with dementia confirmed by gross and microscopic examination of the brain to be caused by cerebrovascular accident or brain tumor and who are confirmed not to have evidence of TSE on microscopic examination of the brain may be acceptable based on an evaluation by the Medical Director). (
  • Under his leadership with the National Cancer Institute-supported Radiation Therapy and Oncology Group Brain Tumor/NRG Translational Research Subcommittee and Brain Tumor Committee, his team's studies have defined the standard of care for patients with central nervous system (CNS) tumors. (
  • Cancer stem cells have been identified and characterized in several tumor types, including acute myeloid leukemia, breast cancer, and glioblastoma ( 1 ). (
  • The cancer cells and stromal cells in tumor microenvironment secrete cytokines and recruit "homing" cells (macrophage, lymphocytes, platelets, etc. (
  • These cells are potentially autologous, however, they pose challenges regarding the amount and kinetics of secreted insulin. (
  • Cheek defect created by removal of a basal cell carcinoma was reconstructed by autologous fibroblasts seeded on a hyaluronic acid sheet. (
  • The present article reviews the case reports and phase I-III clinical evidence using autologous adipose- derived cells that have been published, to date, in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines. (
  • Autologous Platelet-Based Therapies. (
  • The FDA has issued warning letters to stem-cell clinics across the country that utilize the SVF product from donors for autologous use, citing violations such as the lack of a valid biologics license, deviations from current good manufacturing practice and current good tissue practice, such as procedures intended to prevent microbial contamination, process control measures, laboratory testing of drug batches, quality control processes, etc. (
  • We are able to offer patients access to cutting-edge adipose stem cell therapy for each of the degenerative diseases" using autologous stem cell transplants, claims StemGenex, of La Jolla, CA, listing treatments for Alzheimer's, Parkinson's, and MS. "Groundbreaking advancements in autologous stem cell treatment are giving patients the ability to fight back against diseases once thought untreatable," declares the Florida-based Stemedix. (
  • And Cell Surgical Network, with branches all over the country, says that it is "currently studying" autologous stem cell transplants from adipose tissue to treat neurologic conditions like ALS, MS, Parkinson's, Alzheimer's, and muscular dystrophy. (
  • Adipose tissue may represent an ideal source of autologous stem cells, because it is easy to obtain with minimal patient discomfort, but yet capable of yielding cell numbers substantial enough to obviate extensive expansion in culture. (
  • In comments to the Australian Therapeutic Goods Administration (TGA), the ISSCR supported regulation of autologous products that involve more than minimal manipulation of a patient's cells and place strict limitations on the direct advertisement of cell-based therapies. (
  • The comments were in response to the TGA's call for input from interested parties about the regulation of autologous cell and tissue products. (
  • As discussed above, there is no shortage of diseases - both acute and chronic - where adipose-derived cell therapies could have a potential clinical impact. (
  • however, we are hopeful that chronic diseases amenable to SVF cell therapy or ASC therapy will also be identified. (
  • This multidimensional and multidisciplinary book focuses on tissue-specific targeting by nanodrugs, development of bioengineering formats for cell- based, nutraceutical-based, functional-food-based and antibody-based green therapy designed tackle multifaceted diseases and syndromes. (
  • Percentages of the common diseases now treated with mesenchymal stem cells. (
  • Current treatment options for degenerative diseases focus on physical rehabilitation or drug therapies, which temporarily mask the effects of cell damage, but quickly lose their efficacy. (
  • Neurodegenerative diseases affect over 55 million individuals annually in North America, creating a multi-billion dollar burden on the health-care industry due to the costs associated with treatment, and rehabilitation therapy ( Institute for Neurodegenerative Diseases, 2017 ). (
  • Often selective cell loss in the central nervous system (CNS) leads to these neurodegenerative diseases. (
  • Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis, as well as neurodegenerative disorders, such as traumatic brain injury, serve as potential candidates for cell therapy as they result in neuronal death in targeted areas of the brain ( Vila and Przedborksi, 2003 ). (
  • While current treatments for these diseases mainly focus on alleviating symptoms and physical rehabilitation, cell therapy can potentially promote cellular repair and remodeling, resulting in improved function. (
  • Scientists are exploring the possibilities of generating hepatocytes from stem cells as an alternative for the treatment of liver diseases. (
  • In this review, we summarized the updated researches in the field of stem cell-based therapies for liver diseases as well as the current challenges and future expectations for a successful cell-based liver therapy. (
  • UC San Francisco researchers have discovered a new biological pathway in fat cells that could explain why some people with obesity are at high risk for metabolic diseases such as type 2 diabetes. (
  • This collaboration defines a platform which promotes and coordinates research projects from preclinical to clinical phases to improve specific knowledge in two particular field: the first one concerns new products useful in early diagnosis of orthopaedic, cardiovascular, bone tissue inflammatory and/or infective based diseases, diabetic and oncological diseases. (
  • Cell- and tissue-based therapies are being used increasingly to treat many diseases for which currently no other adequate treatment options are available. (
  • With this ability, they have been used to replace defective cells/tissues in patients who have certain diseases or defects. (
  • Several Phase I/II clinical trials are underway to study different types of stem-cell treatments for retinal diseases such as STGD and nonneovascular AMD. (
  • 8 In contrast, adipose-derived stem cell products are not intended for the same function in the patient, and are usually targeted for a spectrum of diseases. (
  • According to, stem cell technology is a rapidly developing field that combines the efforts of cell biologists, geneticists, and clinicians and offers hope of effective treatment for a variety of malignant and non-malignant diseases. (
  • 2020. Is the immunological response a bottleneck for cell therapy in neurodegenerative diseases? . (
  • The company is developing cell-based therapies for several diseases, based upon differentiated cells, derived from hESCs. (
  • Many stem cell 'therapy' websites make the treatment sound as if it's an acknowledged, proven form of therapy for many types of neurologic diseases, orthopedic problems, and other conditions. (
  • As a result of aging, diseases, injury or surgeries, corneal blindness may occur due to dysfunctional human corneal endothelial cells (HCECs), such that there are insufficient numbers and density of HCEC in a disease so called 'bullous keratopathy' (reviewed in [ 4 ]) or fibroblast metaplasia due to endothelial-mesenchymal transition (EMT) [ 5 ]. (
  • Our additional gene therapy pipeline programs for devastating rare diseases remain on track. (
  • These cells and tissues are developed to replace those that are either rendered dysfunctional or lost due to degenerative diseases. (
  • They were able, for the first time, to combine the use of human repair cells that were conditioned during in-vitro culture to maximize their ability to revascularize and improve blood flow to the infarcted tissue with a fully biological composite scaffold designed to deliver these cells to the damaged heart. (
  • In effect, the Columbia Engineering team (with Amandine Godier-Fournemont and Timothy Martens as lead authors) removed the cells of a human heart muscle the myocardium leaving a protein scaffold with intact architecture and mechanical properties. (
  • Moreover, the team also used this controllable platform to identify the signaling mechanisms involved in the repair process, and expand our knowledge about the role of cells and scaffold design on heart repair. (
  • Importantly, there must exist an easily accessible, abundant cell source with the capacity to express the phenotype of the desired tissue, and a biocompatible scaffold to deliver the cells to the damaged region. (
  • We first define the different types of stem cells and their relevant properties and commonly used scaffold formulations. (
  • Next, we discuss natural and synthetic scaffold materials typically used when engineering tissues, along with their associated advantages and drawbacks and gives examples of target applications. (
  • The evidence of cellular change of mouse stem cells in response to a rat scaffold is a promising step toward establishment of a xenogenic scaffold source for engineered kidneys. (
  • In this review, we systematically present and compare the techniques that have drawn the most attention in this field and that generally have focused on four important issues: the scaffold material selection, the scaffold material production, cellular selection and in vitro cell culture. (
  • R. (2005) Tissue Engineering of Bone: Search for a Better Scaffold. (
  • DUBLIN--( BUSINESS WIRE )-- The "FDA's Regulation of Regenerative Medicine including Stem Cell Treatments, Tissue Engineering and Gene Therapies: 2-Day In-person Seminar" conference has been added to Research And Markets' offering. (
  • For questions on the content of this guidance, contact the Division of Human Tissues, Office of Cellular, Tissue and Gene Therapies at 301-827-2002. (
  • The key benefit of ATMP classification is the early involvement and guidance from the EMA's Committee of Advanced Therapies, which is the regulatory reviewing body for gene therapies. (
  • Several adult tissues contain stem cells, but stem cell are dysfunctional or impaired by disease. (
  • Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart via Direct Injection but Not by Vascular Infusion. (
  • They are now investigating the formation of a contractile cardiac patch using human stem cells that can give rise to both the muscle and vascular compartments of the heart muscle . (
  • Here, we have developed vascular endothelial growth factor (VEGF) high-expressing, transiently modified stem cells for the purposes of promoting angiogenesis. (
  • Human adipose tissue is a source of multipotent stem cells. (
  • Following the blastocyst stage, the tissues of the embryo start to form and the cells become multipotent. (
  • 23-26 There is much confusion in the literature when using terms describing multipotent stem cells from the adipose tissue stroma. (
  • Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. (
  • Importantly, these characteristics were more pronounced in ADSCs than bone marrow-derived mesenchymal stem cells, suggesting the therapeutic relevance of ADSC-derived exosomes for AD. (
  • However, in spite of numerous statements in the social media declaring that these cells can be used in medicine for therapeutic purposes, the clinical applications remain few ( Aznar and Sanchez, 2011 ). (
  • The ability to transfer SP cells and create Trm cells to boost the immune system against a patient's cancer could be of therapeutic benefit and needs to be further investigated," explained Dr. Chandra Sekhar Boddupalli, a post-doctoral associate in the Dhodapkar lab and first author of the paper. (
  • The text provides a brief review of each type of perinatal stem cells and then focuses on their multi- or pluripotent properties, regenerative capacity, and future therapeutic potential in regenerative medicine. (
  • But researchers and clinicians have been cautious about promoting potential therapeutic uses for these cells because the insertion of the genes could render the cells cancerous. (
  • These results indicate that stem cells engineered with biodegradable polymer nanoparticles may be therapeutic tools for vascularizing tissue constructs and treating ischemic disease. (
  • Genetic modification of stem cells to express angiogenic factors is a promising approach to further enhance the efficacy of stem cells for therapeutic angiogenesis. (
  • However, previous studies have largely relied on viral vectors to deliver these therapeutic genes to stem cells, which are associated with safety concerns. (
  • Cell therapy goes way beyond the therapeutic reach of a pill, and we will see cost containment in this field for the first time. (
  • The therapeutic use of human cell and tissue products is highly regulated by the U.S. government, but a specific exception allows surgeons to harvest, manipulate, and implant tissues in many commonly performed procedures. (
  • It is made in yeast, a relative outsider in the world of therapeutic protein manufacturing, which is dominated by bacteria and mammalian cell culture. (
  • Our findings indicate the importance of biosafety studies of mesenchymal stem cell biology to efficiently exploit their full clinical therapeutic potential. (
  • The B-Cell Lymphoma Moon Shot is revolutionizing the conventional medical research approach to rapidly translate findings into patient treatment options and develop personalized therapeutic strategies. (
  • While the concept of using polymer-based sustained-release delivery systems to maintain therapeutic concentration of protein drugs for extended periods of time has been well accepted for decades, there has not been a single product in this category successfully commercialized to date despite clinical and market demands. (
  • Electrical Activity in Cardiac Tissue, Modeling of. (
  • They are also studying how the cells within such a cardiac patch, when implanted on infarcted heart tissue, develop their ability to generate mechanical force and electrical conduction, and how these functions can be modulated by in-vitro culture. (
  • NBS10 is thought to work by increasing microvascular blood flow in the heart muscle via the development and formation of new blood vessels, thereby reversing the restriction of blood supply caused by a heart attack and rescuing at-risk cardiac tissue from eventual cell death. (
  • The main approach of cardiac tissue engineering is to create cardiac grafts, either whole heart substitutes or tissues that can be efficiently implanted in the organism, regenerating the tissue and giving rise to a fully functional heart, without causing side effects, such as immunogenicity. (
  • BM chimerism with Sca-1+ cells in aged mice restored the regenerative capability of cardiac resident progenitors and improved functional healing of the aged heart. (
  • Restoration of the Sca-1 subset of stem cells by BM reconstitution improved cardiac repair and prevented heart failure. (
  • Current hypotheses of mechanisms of myoblast actions include limitation of left ventricular remodeling, as well as paracrine effects determining angiogenesis, recruitment of resident quiescent cardiac cells, and extracellular matrix stabilization. (
  • Perinatal Tissue-Derived Stem Cells: Alternative Sources of Fetal Stem Cells, part of Springer's Stem Cell Biology and Regenerative Medicine series, is essential reading for basic and clinical scientists, clinicians, and pharmaceutical experts working or conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, and cellular therapy. (
  • According to the Royan Institute for stem cell biology and technology, Iran is one of the most pioneering countries in the world and the second country in the region in terms of stem cell knowledge and technology. (
  • SCTM is an international peer-reviewed journal, publishing articles focused on advancing the clinical utilization of stem cell molecular and cellular biology. (
  • About STEM CELLS Translational Medicine: STEM CELLS Translational Medicine (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. (
  • Stem cells in epithelial tissues. (
  • Cytokeratin is an epithelial cell marker and Pax-2 is necessary for kidney development. (
  • Examples include epithelial stem cells in epidermis and intestinal crypts ( Slack, 2000 ), neural stem cells in the central nervous system ( McKay, 1997 ) and satellite cells in muscle ( Charge and Rudnicki, 2004 ). (
  • With cells from another individual (allogeneic) or another species (xenogeneic), encapsulation in semipermeable barriers improves immune acceptance, as it inhibits passage of antibodies and excludes cytotoxic cells of the host. (
  • Chow L, Johnson V, Regan D, Wheat W, Webb S, Koch P, Dow S. Safety and immune regulatory properties of canine induced pluripotent stem cell-derived mesenchymal stem cells. (
  • In the lymph node, SLC is believed to play an important role in the initiation of an immune response by colocalizing naive T cells with DC-presenting antigen. (
  • Adoptive cellular therapy uses the body's own T cells to boost its immune system to target cancer. (
  • B7-H3 preferentially down-regulated T H 1-mediated immune response in B7-H3-deficient mice ( 5 ), and 4Ig-B7-H3 inhibited natural killer (NK) cell-mediated lysis of neuroblastoma cells by interacting with a putative inhibitory receptor on the surface of NK cells ( 6 ). (
  • Because the cells activate an immune response similar to inflammation in the presence of viral genetic material, the researchers termed the process "transflammation. (
  • At the present time, adult SCs isolated from postnatal tissues are widely used in clinical applications. (
  • The successful isolation of pluripotent embryonic stem (ES) cells from the inner cell mass of early embryos has provided a powerful tool for biological research. (
  • The ethical issues related to their isolation have promoted the development of induced pluripotent stem (iPS) cells, which share many properties with ES cells without ethical concerns. (
  • Our goal was achieved by isolation and transfection of adipose-derived stromal cells (ADSCs) with adenovirus encoding the cDNA of VEGF. (
  • Stem cells are promising therapeutics for revascularization because of their capability of self-renewal, relative ease of isolation, and ability to migrate toward the ischemic tissues ( 4 ). (
  • Isolation of adipose tissue-derived mesenchymal stem cell. (
  • Isolation and nomenclature of adipose tissue-derived cells. (
  • About GenCure: GenCure, a Texas nonprofit corporation, focuses on regenerative medicine and uses the power of human cells and tissues to inspire hope, enhance lives and enable clinical advancements. (
  • This body of work has provided evidence supporting clinical translational applications of adipose-derived cells in safety and efficacy trials. (
  • The next steps will include documenting the reproducibility of the current preclinical and clinical findings, and controlled testing of the safety and efficacy of ASCs and SVF cells in a range of human conditions. (
  • This stem-cell product is not approved by the FDA, and the risks and efficacy are largely uncharacterized. (
  • The American Cancer Society warned in 2010 that evidence for the efficacy of ozone therapy against cancer is inconclusive, and the therapy may be dangerous. (
  • PC12 cells have been reported to be capable of endogenous NGF synthesis and secretion. (
  • RCKT ) ("Rocket"), a leading U.S.-based multi-platform gene therapy company, today reported financial results for the quarter ended June 30, 2018, and provided an update on the Company's recent achievements, as well as upcoming milestones. (
  • In May 2018, Rocket and the Stanford University School of Medicine announced a strategic collaboration to support the advancement of FA and PKD gene therapy research. (
  • Osteogenic potential of postnatal skeletal muscle-derived stem cells is influenced by donor sex. (
  • Published definition of the cell identity with a panel of surface antigens and establishment of universally applied quality assurance/ quality control testing criteria would benefit the fledgling adipose stem cell community. (