Mesenchymal Stromal Cells
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Mesenchymal Stem Cell Transplantation
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Access to Information
Journal Impact Factor
Peer Review, Research
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Biological Science Disciplines
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Anterior Cruciate Ligament
The MUSCLES, bones (BONE AND BONES), and CARTILAGE of the body.
Anterior Cruciate Ligament Reconstruction
Rebuilding of the ANTERIOR CRUCIATE LIGAMENT to restore functional stability of the knee. AUTOGRAFTING or ALLOGRAFTING of tissues is often used.
Microscopy, Atomic Force
A type of scanning probe microscopy in which a probe systematically rides across the surface of a sample being scanned in a raster pattern. The vertical position is recorded as a spring attached to the probe rises and falls in response to peaks and valleys on the surface. These deflections produce a topographic map of the sample.
Bone Marrow Cells
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Connective Tissue Cells
A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.
Hair Cells, Auditory
Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound.
Organ of Corti
Hair Cells, Auditory, Inner
Stem Cell Transplantation
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body.
Hair Cells, Auditory, Outer
Sensory cells of organ of Corti. In mammals, they are usually arranged in three or four rows, and away from the core of spongy bone (the modiolus), lateral to the INNER AUDITORY HAIR CELLS and other supporting structures. Their cell bodies and STEREOCILIA increase in length from the cochlear base toward the apex and laterally across the rows, allowing differential responses to various frequencies of sound.
Neural Regeneration Research
Topics covered include neural stem cells, neural tissue engineering, gene therapy, and minimally-invasive treatment of ... evidence-based case reports, and perspectives. The journal is abstracted and indexed in BIOSIS Previews, Chemical Abstracts, ... Neural Regeneration Research is a peer-reviewed scientific journal covering research on neuroregeneration and stem cells. ...
... which allows the selective destruction of cancer cells without any damage to normal tissues. It is a light-based cancer therapy ... Based on the current hypothesis, cell death induced by PIT was caused by rapid expansion of local water upon the formation of ... "Immunological responses triggered by photothermal therapy with carbon nanotubes in combination with anti-CTLA-4 therapy to ... Conventional photodynamic therapy (PDT) uses a non-specific photosensitizer which can be activated by a non-ionizing light to ...
Gibbon ape leukemia virus
Retroviral vectors are used in ex vivo gene therapy, which involves the modification of cells in vitro, to replace genes that ... patients with porcine-based liver or pancreatic xenografts, and butchers in contact with porcine tissue. GaLV Envelope Protein ... Entry into host cell: Then GaLV particles use these cell-surface proteins on the cell membrane, as specific receptors to enter ... and Snyder et al., 1973) GALV‐X: detected in cell culture from a human T-cell line infected with HIV-1 in Louvain, Belgium and ...
Hao, L; Lawrence, J; Chian, KS (2005). "Osteoblast cell adhesion on a laser modified zirconia based bioceramic". Journal of ... Chai, Chou; Leong, Kam W (2007). "Biomaterials Approach to Expand and Direct Differentiation of Stem Cells". Molecular Therapy ... Since the elastic modulus values of ceramic materials are generally higher than that of the surrounding bone tissue, the ... While cell culture tests show a good biocompatibility, the analysis of implants shows significant wear, related to a ...
Of the four types, mRNA-based therapy is the only type which is based on triggering synthesis of proteins within cells, making ... whole cells, and even specific tissues. Examples of RNA aptamer molecular targets and potential targets include vascular ... doi:10.1016/j.cell.2009.01.002. PMC 3794896. PMID 19167326. Zhu G, Chen X (September 2018). "Aptamer-based targeted therapy". ... February 2012). "mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients". ...
Regeneration in humans
Kabu, S.; Gao, Y.; Kwon, B.K.; Labhasetwar, V. (2015). "Drug delivery, cell-based therapies, and tissue engineering approaches ... In humans with non-injured tissues, the tissue is naturally regenerated over time; by default these tissues have new cells ... 2014). "Humans iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration". ... It has been shown that bone marrow-derived cells could be the source of progenitor cells of multiple cell lineages, and a 2004 ...
Foundation and Methuselah Foundation for development of rejuvenation therapies based on periodic repair of the cell and tissue ... Some of the themes supported were medical research, environmental conservation, human rights and psychedelic therapy. The ...
Silibinin prevents the uptake of amatoxins by liver cells, thereby protecting undamaged liver tissue; it also stimulates DNA- ... According to one report based on a treatment of 60 patients with silibinin, patients who started the drug within 96 hours of ... Silibinin and N-acetylcysteine appear to be the therapies with the most potential benefit. Repeated doses of activated carbon ... essential protein synthesis and hence cell metabolism grind to a halt and the cell dies. The liver is the principal organ ...
The result is supposed to be selective damage or elimination of tumor cells while normal tissues are unharmed. However, tests ... Much of their claims of effectiveness were based upon anecdotal reports, not research. In fact, the wavelength of light used to ... The FDA-approved therapy PDT uses red light (wavelength approximately 600-700 nm) and penetrates human tissue up to 2 ... Cytoluminescent Therapy is a proposed cancer treatment as a form of Photodynamic Therapy (PDT) characterized by a ...
... outside the cell they can damage tissue. Proponents suggest that its effects are tissue dependent, though the subject is still ... Ozone-based treatments can be associated with central nervous system toxicity, termed Ozone Induced Encephalopathy (OIE). OIE ... Ozone therapy, Autologous ozone blood therapy, Oxygen-ozone autologous blood therapy, Oxyon therapy, Hyperbaric ozone therapy: ... Proponents of the therapy falsely claim it is a recognized therapy there, but ozone therapy is not approved by the German ...
... it has been proposed that stem cells be used in cell-based therapies to replace injured or diseased cells and tissues. Examples ... Stem cell Embryonic stem cell Induced pluripotent stem cell Induced stem cells Adult stem cell Cell culture Immortalised cell ... A stem cell line is also distinct from primary cells. Primary cells are cells that have been isolated and then used immediately ... Stem cell lines are derived from either animal or human tissues and come from one of three sources: embryonic stem cells, adult ...
Stem cell secretome
... the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their ... also known as the tissue matrix. Stem Cell therapies, here referred to as therapies employing non-hematopoietic, mesenchymal ... This approach is also known as cell-free stem cell therapy. It has been hypothesized that future therapies aiming at generating ... With regard to orthopaedic conditions such as arthritis, the paracrine factors of stem cell-based therapies appeared to be ...
Adult stem cell
Christoforou, N; Gearhart, JD (May-June 2007). "Stem cells and their potential in cell-based cardiac therapies". Progress in ... Pluripotent stem cells, i.e. cells that can give rise to any fetal or adult cell type, can be found in a number of tissues, ... Intestinal stem cells reside near the base of the stem cell niche, called the crypts of Lieberkuhn. Intestinal stem cells are ... "Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis". ...
Tissue engineering of heart valves
"Cardiac tissue engineering and regeneration using cell-based therapy". Stem Cells and Cloning: Advances and Applications. 8: 81 ... Cell line as well as cell type such as fibroblasts can largely impact tissue responses towards implanted foreign devices by ... "Scaffolds and cells for tissue regeneration: different scaffold pore sizes-different cell effects". Cytotechnology. 68 (3): 355 ... Furthermore, cells release reactive oxygen species and cytokines, which cause secondary damage to surrounding tissue. These ...
Chronic multifocal Langerhans cell histiocytosis
The diagnosis may be suspected based on symptoms and MRI and confirmed by tissue biopsy. Blood tests may show anaemia, and less ... Diagnosis is confirmed by tissue biopsy. Treatment may involve surgery, chemotherapy, radiation therapy, and certain medicines ... In 1973, Christian Nezelof recognised the abnormal cell as a 'Langerhans-like' cell, however it took another ten years for the ... The mutations causes white blood cells (lymphocytes, macrophages, and eosinophils) to move towards dendritic cells, resulting ...
Network of Excellence for Functional Biomaterials
NFB is also developing cell-based therapies for tendon repair. Wound repair results from a complex and highly orchestrated ... Tendon repair therapies rely heavily on tissue grafts and synthetic biomaterials. However, the limited supply of autografts in ... leaking chemicals of these polymers are often deleterious to the surrounding cells and tissue and immobilise post-operative ... It is based at the National University of Ireland, Galway, and is directed by Professor Abhay Pandit. NFB specialises in the ...
Anterior cruciate ligament reconstruction
"Hierarchical scaffold design for mesenchymal stem cell-based gene therapy of hemophilia B." Current Opinion in Chemical Biology ... these cell types include osteoblasts (bone cells), adipocytes (fat cells), and chondrocytes (cartilage cells). Ligament tissue ... Stem cell treatment. Autologous stem-cell transplantation using mesenchymal stem cells (MSCs) has been used to improve ... Ligament cells differ in size, respond to different cues in the cell environment, and express different cell surface markers, ...
It differs in pathology from GME by more tissue breakdown and increased eosinophils (white blood cells). CSF analysis is also ... Definitive diagnosis is based on histopathology, either a brain biopsy or post-mortem evaluation (necropsy). A CT scan or MRI ... There is evidence that treatment with radiation therapy for focal GME provides the longest periods of remission. Pug Dog ... The blood vessels of the posterior segment of the eye and anterior uvea have the same infiltrates of inflammatory cells as the ...
Biochemistry of Alzheimer's disease
... but are a result of widespread brain tissue damage, damage so widespread that cell-replacement therapies are likely to be ... A mechanism for neurotoxicity has been proposed based on the loss of microtubule-stabilizing tau protein that leads to the ... Cell. 2015 Jun 18;161(7):1592-605. doi: 10.1016/j.cell.2015.05.032. Epub 2015 Jun 4. PMID 26052046; PMCID: PMC4886855 Thadathil ... The possibility of cell-replacement therapy was investigated on the basis of this hypothesis. All of the first-generation anti- ...
... the brain with either stem cell transplant or gene therapy does not immediately normalize the VLCFA levels in body tissues. The ... Symptoms vary based on the disease phenotype, and even within families or between twins. When ALD is suspected based on ... "Hematopoietic Stem Cell Transplantation and Hematopoietic Stem Cell Gene Therapy in X-Linked Adrenoleukodystrophy". Brain ... The most severely affected tissues are the myelin in the central nervous system, the adrenal cortex, and the Leydig cells in ...
Cell-based therapies for Parkinson's disease
... cell transplantation has focused on various dopamine producing cells throughout the body. fetal ventral mesencephalic tissue ( ... pigment epithelium embryonic stem cells induced pluripotent stem cells mesenchymal stem cells The first cell-based therapy ... It includes two populations of cells; glomus (type I) cells and sustentacular (type II) cells. Glomus cells are derived from ... Cell-based therapies for Parkinson's disease include various investigational procedures which transplant specific populations ...
Somatic cell nuclear transfer
This fact may also hamper the potential benefits of SCNT-derived tissues and organs for therapy, as there may be an immuno- ... The following year, this method achieved a key goal of SCNT-based stem cell research: the derivation of pluripotent stem cell ... 1], Nature Stem Cell Blog. , The Scientist 19 June 2007 Human Somatic Cell Nuclear Transfer Using Adult Cells Cell Stem Cell ... The second being a somatic cell, referring to the cells of the human body. Skin cells, fat cells, and liver cells are only a ...
Cell-based pro-angiogenic therapies are still early stages of research, with many open questions regarding best cell types and ... A decade of clinical testing both gene- and protein-based therapies designed to stimulate angiogenesis in underperfused tissues ... and cell-based therapies, which involve the implantation of specific cell types. There are still serious, unsolved problems ... A large number of preclinical studies have been performed with protein-, gene- and cell-based therapies in animal models of ...
Mesenchymal stem cell
Stromal cells are connective tissue cells that form the supportive structure in which the functional cells of the tissue reside ... "FDA Warns About Stem Cell Therapies". FDA. Murphy MB, Moncivais K, Caplan AI (November 2013). "Mesenchymal stem cells: ... Other flow cytometry-based methods allow the sorting of bone marrow cells for specific surface markers, such as STRO-1. STRO-1+ ... May 2012). "Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis". Cell Stem Cell ...
Extracranial germ cell tumor
... or the tissues where it influence the growth of tumor cells. Salvage Therapy: this treatment is given if there is no response ... the platinum-based chemotherapy drugs reduce the growth of tumor cell or destroy the tumor cells in order to prevent the cells ... Ovarian Germ Cell Tumor Extragonadal Germ Cell Tumor Cancer.net: Germ Cell Tumor include extracranial germ cell tumor ... Inside the tumor tissue, clustered of tumor cells is shown. Furthermore, by examining the tumor cells individually, it has ...
... "based on genes, cells, or tissue engineering", including gene therapy medicines, somatic-cell therapy medicines, tissue- ... somatic cells, gene therapies, tissues, recombinant therapeutic protein, and living cells used in cell therapy. Biologics can ... mammalian cell lines (see cell culture) and plant cell cultures (see plant tissue culture) and moss plants in bioreactors of ... Many vaccines are grown in tissue cultures. Gene therapy. Viral gene therapy involves artificially manipulating a virus ...
... allowing cells to freely move around. CD52 binds the ITIM (immunoreceptor tyrosine-based inhibitory motif)-bearing sialic acid- ... "Peripheral blood but not tissue dendritic cells express CD52 and are depleted by treatment with alemtuzumab". Blood. 100 (5): ... when used as a first-line therapy. However, a sister study looking at patients in whom relapses had occurred despite treatment ... Further, it is found within the male genital tract and is present on the surface of mature sperm cells. CD52 is a peptide of 12 ...
Leroy Stevens first described cells that can develop into different tissues - today known as stem cells. Dr. Elizabeth Russell ... The National Institute on Aging provides $25 million to develop new treatments, future therapies based on precision modeling. ... cancer cell robustness, genomic and genetic complexity, and progenitor cell biology. The themes emphasize the systems genetics ... Is pioneering the use of cancer avatars - mice with implanted human tumors - to test targeted therapies for cancer patients. ...
Post-transplant lymphoproliferative disorder
"Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 ... This may be evaluated with an MRI of the brain with gadolinium based contrast and lumbar spinal tap with testing of the ... Definitive diagnosis is achieved by biopsying the involved tissue, which will reveal lymphoproliferative neoplasia. Most ... the malignant cell clone can become the dominant proliferating cell type, leading to frank lymphoma, a group of B cell ...
Molecular logic gate
... example would take advantage of the higher sodium levels and lower pH in tumor tissue compared to the levels in normal cells. ... Molecular logic gates work with input signals based on chemical processes and with output signals based on spectroscopy. One of ... A recent study illustrates the application of a logic gate for photodynamic therapy. A bodipy dye attached to a crown-ether ... Upon addition of both an acid and a base, the emission of the molecule is observed as red, as the tertiary amine would not be ...
Photoelectric cells in a spectrophotometer device worn on the forehead measure the amount of each wavelength of light reflected ... Neurofeedback, a specific form of biofeedback, is based on the idea that human beings can consciously alter their brain ... Mize, W. (2004). Hemoencephalography-a new therapy for attention deficit hyperactivity disorder (ADHD): case report. Journal of ... which are responsible for the transport and transference of oxygen to tissue throughout the body, must increase the amount of ...
Type 2 diabetes
The molecular bases of beta cell mass reduction in type 2 diabetes". Seminars in Cell and Developmental Biology. doi:10.1016/j. ... "An Evidence-Based Medicine Approach to Antihyperglycemic Therapy in Diabetes Mellitus to Overcome Overtreatment". Circulation. ... and fat tissue. In the liver, insulin normally suppresses glucose release. However, in the setting of insulin resistance, ... a type 2 diabetic will have lost about half of their beta cells. Fatty acids in the beta cells activate FOXO1, resulting in ...
Mice lacking plakoglobin have cell adhesion defects in many tissues, although β-catenin substitutes for plakoglobin at many ... Recently, there have been a number of studies in the lab and in the clinic investigating new possible therapies for cancers ... but much more work is needed before an adequate treatment based on this concept can be determined. Lab studies have also ... F9 embryonal carcinoma cells are similar to the P19 cells shown in Figure 1 and normally have cell-to-cell adhesion mediated by ...
... amino acid therapy may be helpful for regenerating damaged or atrophied muscle tissue. The branched-chain amino acids or BCAAs ... Based upon a meta-analysis of seven randomized controlled trials that was published in 2015, HMB supplementation has efficacy ... "satellite cells" which help to regenerate skeletal muscle fibers, and a decrease in sensitivity to or the availability of ... A CT scan can distinguish muscle tissue from other tissues and thereby estimate the amount of muscle tissue in the body. Fast ...
Positron emission tomography
... cannot exit from the cell. This results in intense radiolabeling of tissues with high glucose uptake, such as the normal brain ... Statistical, likelihood-based approaches: Statistical, likelihood-based  iterative expectation-maximization algorithms ... PET has an expanding role as a method to assess the response to therapy, in particular, cancer therapy, where the risk to ... based regularization in a wavelet or other domain), such as via Ulf Grenander's Sieve estimator or via Bayes penalty ...
... dendritic cells and other cells including liver cells, fibroblasts, and adrenal gland cells. Viral replication triggers ... Developments in organ-on-a-chip technology have led to a chip-based model for Ebola haemorrhagic syndrome. ... "Experimental therapies: growing interest in the use of whole blood or plasma from recovered Ebola patients (convalescent ... Hazelton's veterinary pathologist sent tissue samples from dead animals to the United States Army Medical Research Institute of ...
"A Review of hormone-based therapies to treat adult acne vulgaris in women". International Journal of Women's Dermatology. 3 (1 ... and Th1 cells. IL-1α stimulates increased skin cell activity and reproduction, which, in turn, fuels comedo development.[45 ... the follicle can break into the deeper layers of the dermis and subcutaneous tissue and cause the formation of deep nodules. ... Combination therapy. Combination therapy-using medications of different classes together, each with a different mechanism ...
... stem cells, white blood cells) in many tissues and organs. SP amplifies or excites most cellular processes. ... Muñoz M, Rosso M, Coveñas R (Jun 2011). "The NK-1 receptor: a new target in cancer therapy". Current Drug Targets. 12 (6): 909- ... the peptide based NK1RA) against cisplatin-induced emesis in the ferret. It is likely that some peripheral exposure ... Cell growth, proliferation, angiogenesis, and migrationEdit. The above processes are part and parcel to tissue integrity and ...
Hematopoietic stem cell transplantation
As of 2013[update], there were at least two commercialized allogeneic cell therapies, Prochymal and Cartistem. ... It is an attack by the "new" bone marrow's immune cells against the recipient's tissues. This can occur even if the donor and ... In addition, a genetic mismatch as small as a single DNA base pair is significant so perfect matches require knowledge of the ... who have lost their stem cells after birth. Other conditions treated with stem cell transplants include sickle-cell disease ...
... therapy should be continued during pregnancy. Furthermore, therapy should be immediately administered to women diagnosed ... Grapefruit juice may delay the absorption of levothyroxine, but based on a study of 10 healthy people aged 20-30 (8 men, 2 ... T4 and T3 bind to thyroid receptor proteins in the cell nucleus and cause metabolic effects through the control of DNA ... Mandel SJ, Brent GA, Larsen PR (September 1993). "Levothyroxine therapy in patients with thyroid disease". Annals of Internal ...
Tüvirakud - Vikipeedia, vaba entsüklopeedia
"Stem-cell therapy shows promise for horse soft-tissue injury, disease". DVM Newsmagazine. Vaadatud 2013-10-21. ... "Biocell Center Corporation Partners with New England's Largest Community-Based Hospital Network to Offer a Unique... - MEDFORD ... Lindvall O (2003). "Stem cells for cell therapy in Parkinson's disease". Pharmacol Res 47 (4): 279-87. PMID 12644384. ... Wu DC, Boyd AS, Wood KJ (2007). "Embryonic stem cell transplantation: potential applicability in cell replacement therapy and ...
... or prescribe pharmaceutical drugs or other therapies. Differential diagnosis methods help to rule out conditions based on the ... Histology is the study of the structures of biological tissues by light microscopy, electron microscopy and ... discovered by Paul Ehrlich in 1908 after he observed that bacteria took up toxic dyes that human cells did not. The first major ... "know the best course for", from PIE base *med- "to measure, limit. Cf. Greek medos "counsel, plan", Avestan vi-mad "physician" ...
It has received regulatory approval for use as a treatment for non-small cell lung cancer, although there is ... February 2015). "Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and ... and is currently the preferred EGFR-TKI therapy for exon 18 mutations (particularly G719x).[verification needed] ... Connective tissue growth factor (CTGF). *Ephrins (A1, A2, A3, A4, A5, B1, B2, B3) ...
Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells.[ ... organolithium compounds are extremely powerful bases and nucleophiles. For use as bases, butyllithiums are often used and are ... Sartori, H. E. (1984). "Cesium therapy in cancer patients". Pharmacol Biochem Behav. 21 (Suppl 1): 11-13. doi:10.1016/0091-3057 ... organ changes and tissue accumulation". Journal of Environmental Science and Health, Part A. 16 (5): 549-567. doi:10.1080/ ...
"Tissue Antigens. 64 (5): 575-80. doi:10.1111/j.1399-0039.2004.00310.x. PMID 15496200.. ... In 1975, association with "HL-A1,8" (Current name: HLA A1-B8) was confirmed by serological typing of cells from myasthenics.[11 ... Rocca P, Codes L, Chevallier M, Trépo C, Zoulim F (November 2004). "[Autoimmunization induced by interferon alpha therapy in ... June 2004). "Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic ...
Radiation therapyEdit. The goal of radiation therapy is to kill tumor cells while leaving normal brain tissue unharmed. In ... The decision to prescribe this treatment is based on a patient's overall health, type of tumor, and extent of the cancer. The ... Experimental treatments include targeted therapy, gamma knife radiosurgery, boron neutron capture therapy and gene therapy. ... Anaplastic cells have lost total control of their normal functions and many have deteriorated cell structures. Anaplastic cells ...
... and is produced in a tissue-selective manner based on expression of 5α-reductase. Tissues in which DHT forms at a high ... Katsambas AD, Dessinioti C (2010). "Hormonal therapy for acne: why not as first line therapy? facts and controversies". Clin. ... stimulating cell division and tissue growth. In accordance, therapeutic modalities that reduce androgen signaling in the ... See also: Management of prostate cancer § Hormonal therapy, and Androgen deprivation therapy ...
Intravenous interferon therapy has also been used. When Lassa fever infects pregnant women late in their third ... Other laboratory findings in Lassa fever include lymphocytopenia (low white blood cell count), thrombocytopenia (low platelets ... Diagnosis based on symptoms is difficult. Confirmation is by laboratory testing to detect the virus's RNA, antibodies for ... This is because the virus has an affinity for the placenta and other highly vascular tissues. The fetus has only a one in ten ...
... pus cells in the urine (pyuria) or cancer cells in the urine. A 24-hour urine collection can be used to quantify daily protein ... of a core biopsy needle into the kidney to obtain a small sample of kidney tissue. The kidney tissue is then examined under a ... Nearly all programs train nephrologists in continuous renal replacement therapy; fewer than half in the United States train in ... is a national organization that represents and supports the independent and community-based dialysis providers. The American ...
This stem-based definition is equivalent to the more common definition of Sauropsida, which Modesto and Anderson synonymized ... Morphological and cellular aspects of tail and limb regeneration in lizards a model system with implications for tissue ... "Theraputic potential of snake venom in cancer therapy: current perspective". Asian Pacific Journal of Tropical Medicine. 3 (2 ... Cell. 25 (4): 326-328. doi:10.1016/j.devcel.2013.05.011. PMID 23725759.. ...
Newer vaccines, based on vero cells, are in development and should replace 17D at some point. ... A French team developed the French neurotropic vaccine (FNV), which was extracted from mouse brain tissue. Since this vaccine ... it had been previously discounted as a possible therapy. Infection was reduced in mosquitoes with the wMel strain of ... The viruses infect, amongst others, monocytes, macrophages, and dendritic cells. They attach to the cell surfaces via specific ...
Sex reassignment surgery
Further in the future, stem cell biotechnology may also make this possible, with no need for anti-rejection drugs. ... Monstrey, S.; Vercruysse Jr., H.; De Cuypere, G. (2009). "Is Gender Reassignment Surgery Evidence Based? Recommendation for the ... After sex reassignment surgery, transsexuals (people who underwent cross-sex hormone therapy and sex reassignment surgery) tend ... non-penile inversion techniques that make use of scrotal tissue to construct the vaginal canal. For trans men, genital ...
Hyperimmunoglobulin E syndrome
Most patients with hyper IgE syndrome are treated with long-term antibiotic therapy to prevent staphylococcal infections. Good ... and DOCK8-hyper-IgE syndromes differ in IgE-based sensitization pattern". Allergy. 69: 943-953. doi:10.1111/all.12416. ISSN ... balloon-like lesions that may be filled with air or pus or scar tissue) and very high concentrations of the serum antibody IgE ... T cell deficiency. (T). *thymic hypoplasia: hypoparathyroid (Di George's syndrome). *euparathyroid (Nezelof syndrome ...
"Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture". Cell. 157 ... Gottschlich, Michele M. (2001). The Science and Practice of Nutrition Support: A Case-based Core Curriculum. Kendall Hunt. p. ... Schlenker, Eleanor; Gilbert, Joyce Ann (28 August 2014). Williams' Essentials of Nutrition and Diet Therapy. Elsevier Health ... doi:10.1016/j.cell.2014.05.009. PMC 4144415 . PMID 24906154.. *^ Anke M. Arsenic. In: Mertz W. ed., Trace elements in human and ...
肥胖症 - 维基百科，自由的百科全书
Adipose Tissue And Adipokines in Health And Disease (Nutrition and Health). Totowa, NJ: Humana Press. 2006: 222. ISBN 1-58829- ... Science-Based Solutions to Obesity: What are the Roles of Academia, Government, Industry, and Health Care? Proceedings of a ... Expert review of cardiovascular therapy (Review). 2011-03, 9 (3): 265-77. PMID 21438803. doi:10.1586/erc.10.22.. ... Cell (Review). 2004, 116 (2): 337-50. PMID 14744442. doi:10.1016/S0092-8674(03)01081-X.. ...
2008). "Hand Transplantation: The Innsbruck Experience". Transplantation of Composite Tissue Allografts. pp. 234-250. doi: ... On January 13, 2015, doctors at the Kochi-based Amrita Institute of Medical Sciences and Research Centre (AIMS) successfully ... After the transplant, there is a period of extensive hand therapy/rehabilitation which helps the recipients regain function of ... Those patients who are dedicated to taking the medications and performing the physical therapy following a hand transplant have ...
Cancer therapy. Pharmaceutical companies have been designing cancer therapy drugs to target DNA in traditional methods ... The CAAT box is located about 75-80 bases upstream of the transcription initiation site and about 150 bases upstream of the ... "Molecular Cell. 68 (1): 130-143.e5. doi:10.1016/j.molcel.2017.08.016. PMC 5632562. PMID 28918903.. ... regulatory region of the tissue factor gene and the risk of myocardial infarction and venous thromboembolism: the ECTIM and ...
Knee cartilage replacement therapy
... or re-grow cartilage tissue to replace missing or damaged cartilage. One cell-based replacement technique is called autologous ... Then these cells are injected into the patient. These cells are held in place by a small piece of soft tissue from the tibia, ... The cells grow in self-organized spheroid matrices which are implanted via injected fluid or inserted tissue matrix. For years ... An advantage to this approach is that a person's own stem cells are used, avoiding tissue rejection by the patient's immune ...
Stem-cell therapy. *Tissue engineering. *Robot-assisted surgery. *Synthetic biology *Synthetic genomics ... This truck is one of 15 based at Walmart's Buckeye, Arizona distribution center that was converted to run on a biofuel made ... Syngas may be burned directly in internal combustion engines, turbines or high-temperature fuel cells. The wood gas ... The NFESC, with Santa Barbara-based Biodiesel Industries, is working to develop biofuels technologies for the US navy and ...
多囊卵巢綜合症 - 维基百科，自由的百
Adipose tissue possesses aromatase（英语：aromatase）, an enzyme that converts androstenedione to estrone and testosterone to ... Feig, Denice S.; Moses, Robert G. Metformin Therapy During Pregnancy Good for the goose and good for the gosling too?. Diabetes ... Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines. Hum ... and interleukin-1 in modulating progesterone and oestradiol production by human luteinized granulosa cells in culture. Hum. ...
Current Treatment Limitations in Age-Related Macular Degeneration and Future Approaches Based on Cell Therapy and Tissue...
Submissions should focus on focusing on new diagnostic and surgical techniques, instrument and therapy updates, as well as ... many options involving cell therapy mainly based on retinal and iris pigment epithelium cells as well as stem cells are being ... Current Treatment Limitations in Age-Related Macular Degeneration and Future Approaches Based on Cell Therapy and Tissue ... 2Tissue Engineering and Biomaterials Unit, CEIT and TECNUN (University of Navarra), Paseo de Manuel Lardizabal 15, 20018 San ...
Collagen-based biomaterials as 3D scaffold for cell cultures: applications for tissue engineering and gene therapy
... Med Biol Eng ... The principal biochemical and biological characteristics of the collagen-based biomaterials are presented, including their ... interactions with cells (fibroblasts), distinct from those of synthetic polymers, and their potential use in gene therapy ... With the rapid development in tissue engineering, these different biomaterials have been used as three-dimensional scaffolds ...
Mesenchymal Stem Cell-Based HLA-Independent Cell Therapy for Tissue Engineering of Bone and Cartilage | BenthamScience
Current Stem Cell Research & Therapy. Title: Mesenchymal Stem Cell-Based HLA-Independent Cell Therapy for Tissue Engineering of ... Mesenchymal Stem Cell-Based HLA-Independent Cell Therapy for Tissue Engineering of Bone and Cartilage. Author(s): Philipp ... Keywords: Mesenchymal Stem Cells, HLA-antigen, Tissue Engineering, bone regeneration, cartilage repair ... Keywords:Mesenchymal Stem Cells, HLA-antigen, Tissue Engineering, bone regeneration, cartilage repair ...
Gene expression-based enrichment of live cells from adipose tissue produces subpopulations with improved osteogenic potential |...
... of fat tissue are a particularly attractive option for cell based therapy given their accessibility and relative abundance. ... The objective of this study was to determine whether SVF cells sorted based on expression of alkaline phosphatase liver/bone/ ... Cells positive for ALPL expression (ALPL+) represented approximately 34% of the gated population, while cells negative for ALPL ... Cells were separated into positive and negative groups using fluorescence-activated cell sorting (FACS) then differentiated ...
Cell-based therapy in the repair of osteochondral defects: A novel use for adipose tissue | [email protected]
Research Keyword Faculty Listing | Yale School of Medicine
Cell- and Tissue-Based Therapy. Jiangbing Zhou, PhD Associate Professor Term. Research Interests. Biocompatible Materials; ... Biomedical Engineering; Brain Injuries; Brain Neoplasms; Cell- and Tissue-Based Therapy; Drug Delivery Systems; Genetic Therapy ...
Biomaterials and Stem Cells: Promising Tools in Tissue Engineering and Biomedical Applications | IntechOpen
... in the fields of biomaterial and medical sciences constitutes a challenge for the development of effective therapies in humans ... Stem cells (SCs) are a unique cell type capable of self‐renewal and reconstructing damaged tissues. At the present time, adult ... are already used as implants to replace or improve the functionality of the damaged tissue or organ. However, the continuous ... Biomaterial sciences and tissue engineering approaches are currently fundamental strategies for the development of regenerative ...
Tissue repairing cells that exist among mesenchymal stem cells; their potential for cell-based therapy].<...
... their potential for cell-based therapy].. Together they form a unique fingerprint. * Cell- and Tissue-Based Therapy Medicine ... Tissue repairing cells that exist among mesenchymal stem cells; their potential for cell-based therapy]. / Dezawa, Mari. ... Tissue repairing cells that exist among mesenchymal stem cells; their potential for cell-based therapy]. In: Nihon rinsho. ... Tissue repairing cells that exist among mesenchymal stem cells; their potential for cell-based therapy]. Nihon rinsho. Japanese ...
Stem Cells and Cloning: Advances and Applications | Volume 8 - Dove Press
Â Areas of interestÂ will beÂ established and emerging concepts in stem cell research.Indexed on:American Chemical Societys ... Cardiac tissue engineering and regeneration using cell-based therapy Alrefai MT, Murali D, Paul A, Ridwan KM, Connell JM, Shum- ... Human adipose stem cell and ASC-derived cardiac progenitor cellular therapy improves outcomes in a murine model of myocardial ... Mesenchymal stem cell therapy for osteoarthritis: current perspectives Wyles CC, Houdek MT, Behfar A, Sierra RJ ...
Cell-based regenerative therapy has the potential to correct bone tissue injuries | EGFR Tyrosine Kinase Inhibitors Activate...
Cell-based regenerative therapy has the potential to correct bone tissue injuries. by buyresearchchemicalss, May 30, 2019. Cell ... Mesenchymal stem cells (MSCs) are an appealing autologous way to obtain somatic stem cells for cell-based bone tissue ... 1. Launch Cell-based regenerative therapy gets the potential to correct harmed or defect-containing bone tissue thats ... Right here, we built multilayered mesenchymal cell (MLMCs) sheet anchored to collagen-binding bFGF utilizing a book cell tissue ...
Cell therapy for wound healing. - PubMed - NCBI
Cell-and Tissue-based Therapy; Tissue Engineering; Wounds and Injuries. PMID:. 24616577. PMCID:. PMC3945123. DOI:. 10.3346/jkms ... Cell therapy has also been developed for chronic wound healing. By transplanting cells with an excellent wound healing capacity ... Cell therapy for wound healing.. You HJ1, Han SK1.. Author information. 1. Department of Plastic Surgery, Korea University ... The purpose of this review is to provide information on clinically available cell-based treatment options for healing of acute ...
Multidifferentiation potential of human mesenchymal stem cells from adipose tissue and hamstring tendons for musculoskeletal...
... potential of human mesenchymal stem cells from adipose tissue and hamstring tendons for musculoskeletal cell-based therapy. ... potential of human mesenchymal stem cells from adipose tissue and hamstring tendons for musculoskeletal cell-based therapy, ... potential of human mesenchymal stem cells from adipose tissue and hamstring tendons for musculoskeletal cell-based therapy. ... potential of human mesenchymal stem cells from adipose tissue and hamstring tendons for musculoskeletal cell-based therapy. / ...
Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells - Seattle Stem Cell Center
Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells. ... Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells ... we are hopeful that chronic diseases amenable to SVF cell therapy or ASC therapy will also be identified. ... Adipose tissue is now recognized as an accessible, abundant, and reliable site for the isolation of. adult stem cells suitable ...
Wiley: Wiley Encyclopedia of Biomedical Engineering, 6 Volume Set - Metin Akay
Scaffolds for Cell and Tissue Engineering.. Semiconductor-Based Implantable Prosthetic Devices.. Sensor Biocompatibility and ... Autologous Platelet-Based Therapies.. Back-Propagation.. Batteries for Implantable Biomedical Applications.. Bayesian Analysis. ... a comprehensive knowledge base for existing and future research. It will be a useful reference on our bookshelves...the editors ... knowledge base. To represent the vast diversity of the field and its multi-and cross-disciplinary nature and serve the BME ...
CiNii Articles - Potential of Periodontal Ligament Cells to Regenerate Alveolar Bone
The therapeutic potential of mesenchymal stem cells. Cell- & tissue-based therapy PICINICH S. C. ... Thus, periodontal ligament cells might be useful for the regeneration of alveolar bone in tissue engineering applications. ... Paravascular cells in endosteal spaces of alveolar bone contribute to periodontal ligament cell populations MCCULLOCH CAG ... Although several periodontal regeneration therapies have been devised, the origin of the undifferentiated cells that regenerate ...
Home | Department of Biomedical Engineering
Cellular-based Therapy for Cartilage Regeneration - focus on Tissue Specific Stem/Progenitor Cells. 20 May 2020 ...
Perspectives in Translational Research in Life Sciences and Biomedicine - Translational Outcomes Research in Life Sciences and...
Tissue Engineering and Cell-Based Therapy in Regenerative Medicine. Banerjee, Ena Ray ... based, nutraceutical-based, functional-food-based and antibody-based green therapy designed tackle multifaceted diseases and ... and cells (tissue engineering of stem cells of embryonic origin, adult tissue origin and umbilical cord-derived) in ... The book discusses topics such as tissue engineering to create lineage-specific cells for tissue-specific regeneration; how ...
Mesenchymal stem cells: a new trend for cell therapy | Acta Pharmacologica Sinica
From animal models to clinical trials, MSCs have afforded promise in the treatment of numerous diseases, mainly tissue injury ... the major stem cells for cell therapy, have been used in the clinic for approximately 10 years. ... and provide an overview of mechanisms that are significant in MSC-mediated therapies. Although MSCs for cell therapy have been ... In this review, we summarize the recent opinions on methods, timing and cell sources for MSC administration in clinical ...
Frontiers | 3-D Bioprinting of Neural Tissue for Applications in Cell Therapy and Drug Screening | Bioengineering and...
Cell therapies for the central nervous system remain an untapped market due to the complexity involved in growing neural ... Cell therapies for the central nervous system remain an untapped market due to the complexity involved in growing neural ... Designing tissue constructs for the discovery of better drug treatments are also limited due to the resolution needed for an ... Designing tissue constructs for the discovery of better drug treatments are also limited due to the resolution needed for an ...
Stem Cell-Based Therapies for Liver Diseases: An Overview and Update | Tissue Engineering and Regenerative Medicine;(6): 107...
Stem Cell-Based Therapies for Liver Diseases: An Overview and Update Stem Cell-Based Therapies for Liver Diseases: An Overview ... cell-based therapies for liver diseases as well as the current challenges and future expectations for a successful cell-based ... Stem cell-based therapy could be a promising therapeutic method for patients with end-stage liver disease, which may alleviate ... induced pluripotent stem cells, liver stem cells, mesenchymal stem cells, and hematopoietic stem cells. In vitro and in vivo ...
Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: A combined gene therapy-cell transplantation...
2001) Multilineage cells from human adipose tissue: Implications for cell-based therapies. Tissue Eng 7:211-228. ... Another aspect of this study is the higher efficiency of the gene therapy strategy by including the use of tissue-specific cell ... 2005) Novel autologous cell therapy in ischemic limb disease through growth factors secretion by cultured adipose tissue- ... Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: A combined gene therapy-cell transplantation ...
Efficient manufacturing of therapeutic mesenchymal stromal cells with the use of the Quantum Cell Expansion System
Cell Differentiation / genetics * Cell Lineage * Cell- and Tissue-Based Therapy* * Humans * Mesenchymal Stem Cell ... Background: The use of bone marrow-derived mesenchymal stromal cells (MSCs) as a cellular therapy for various diseases, such as ... 1 Center for Cell and Gene Therapy, Texas Childrens Hospital, The Methodist Hospital, and Baylor College of Medicine, Houston ... 2 Center for Cell and Gene Therapy, Texas Childrens Hospital, The Methodist Hospital, and Baylor College of Medicine, Houston ...
Biomedical engineers patch a heart using novel tissue cell therapy
Medical Xpress) -- Researchers at Columbia Engineering have established a new method to patch a damaged heart using a tissue- ... engineering platform that enables heart tissue to repair itself. This breakthrough, recently published ... ... DeNeRD: an AI-based method to process whole images of the brain. Oct 17, 2019 ... Citation: Biomedical engineers patch a heart using novel tissue cell therapy (2011, May 6) retrieved 20 October 2019 from https ...
Ozone therapy - Wikipedia
... outside the cell they can damage tissue. Proponents suggest that its effects are tissue dependent, though the subject is still ... Ozone-based treatments can be associated with central nervous system toxicity, termed Ozone Induced Encephalopathy (OIE). OIE ... Ozone therapy, Autologous ozone blood therapy, Oxygen-ozone autologous blood therapy, Oxyon therapy, Hyperbaric ozone therapy: ... Proponents of the therapy falsely claim it is a recognized therapy there, but ozone therapy is not approved by the German ...
Medical Xpress - tissue cells
Medical Xpress is a web-based medical and health news service that features the most comprehensive coverage in the fields of ... Phase III clinical trials for stem cell-based cartilage regeneration therapy have started. A group of researchers at Osaka ... Related topics: cells · embryonic stem cells Cancer Rare melanoma type highly responsive to immunotherapy. Desmoplastic ... Mount Sinai researchers have discovered that normal immune cells called macrophages, which reside in healthy breast tissue ...
Quality Metrics for Drug Manufacturing | FDA
2 cell therapy products; gene therapy products; allergenic extracts; or human cells, tissues, and cellular and tissue based ... Gallen University to study relevant data-based performance metrics which may be useful in predicting risks to quality prior to ... Help the FDA develop compliance and inspection policies and practices, and inform risk-based scheduling of drug manufacturing ... "Measuring Pharmaceutical Quality through Manufacturing Metrics and Risk-Based Assessment," Engelberg Center for Health Care ...
Frontiers | Generation and Applications of Human Pluripotent Stem Cells Induced into Neural Lineages and Neural Tissues |...
The hype is well-earned because of the potential of stem cells to contribute to disease modeling, drug screening, and even ... The hype is well-earned because of the potential of stem cells to contribute to disease modeling, drug screening, and even ... In this review, we focus on neural differentiation of these cells and their biomedical applications. We compare the various ... In this review, we focus on neural differentiation of these cells and their biomedical applications. We compare the various ...
Defining the cellular environment in the organ of Corti following extensive hair cell loss: a basis for future sensory cell...
... the sensory epithelium repairs to close the lesions but no new hair cells arise and hearing impairment ensues. For any cell ... Following the loss of hair cells from the mammalian cochlea, ... Cell Differentiation. Cell- and Tissue-Based Therapy / methods ... inner hair cell; Dc = Deiters cell, ip = inner pillar cell, op = outer pillar cell, Hc = Hensens cell, Cc = Claudius cell, Bc ... cells in the repaired organ of Corti following hair cell loss may be a consideration for the use of stem cell-based therapies ...
New T Cell Subsets Have Potential to Improve Cellular Therapy for Cancer
Our studies showed that human SP cells were capable of greater engraftment and tissue infiltration than unselected T cells upon ... Cell-Squeezing Device Opens New Possibilities for Cell-Based Vaccines Biology Researchers Generate Immune Responses from Stem ... New T Cell Subsets Have Potential to Improve Cellular Therapy for Cancer TOPICS:BiologyCancerDiseaseHealthImmune SystemYale ... Adoptive cellular therapy uses the bodys own T cells to boost its immune system to target cancer. The adoptive transfer of T ...
PSB and Farminerva collaborate to develop diagnostics and new therapeutic in peptide based biopharmaceuticals
Stem cells, Oncology, leukaemia and Immunology; Molecular cardiology; Skeletal regeneration; Cell therapy and tissue ... In a follow-up study, recently published in "Cell Reports", the scientists report that this drug cocktail induces cancer cell ... bone tissue inflammatory and/or infective based diseases, diabetic and oncological diseases. Further effort will be targeted on ... Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells. A widely used diabetes medication combined ...
TransplantationDifferentiateBiomaterialsEmbryonic stemRegenerative therapiesEngineering and regenerative medicinePluripotent cellsMesenchymal cellLineagesAdult stemCellular therapiesHematopoietic StemMSCsCartilageRegenerateBiologyApproaches2019AdvancesEpithelialCardiacGene TherapiesMultipotentBone marrow derivedImmunotherapyTherapeuticBiomaterialImmune2018Postnatal tissuesIsolationHuman cells and tissuesHumansSkeletalAdipose stemUmbilical cordBiological
- One of our major findings is that the murine peritoneal environment, where encapsulated cells are commonly transplanted, is hypoxic and it becomes more hypoxic upon transplantation of islets or other insulin-secreting cells. (aiche.org)
- Results from experiments involving transplantation of murine, insulin-secreting L cells in diabetic mice demonstrated that the graft had a significant positive effect on the glycemic regulation of the animals, however, it did not cure diabetes. (aiche.org)
- On the basis of the available literature, MSC have to be referred to as immune privileged, and they seem to be available for HLA-independent cell transplantation. (eurekaselect.com)
- Alpha-SMA- and BMP4-positive cells were observed near the root surface at 5 days after transplantation. (nii.ac.jp)
- Stem cell-based therapy could be a promising therapeutic method for patients with end-stage liver disease, which may alleviate the need for liver transplantation in the future. (bvsalud.org)
- Another approach is transplantation of retinal pigment epithelium cells derived from either human embryonic stem cells or from the patient's own induced pluripotent stem cells. (aao.org)
- However, the use of stem cells alone to promote angiogenesis remains limited because of insufficient expression of angiogenic factors and low cell viability after transplantation. (pnas.org)
- Genetic modification of MSCs with Akt or Bcl-2 gene also improved the therapeutic efficacy of cell transplantation in treating myocardium ( 11 , 12 ). (pnas.org)
- 2018. Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation . (cardiff.ac.uk)
- At present, the only method to cure corneal endothelial dysfunction is by transplantation of a cadaver donor cornea with normal corneal endothelial cells. (medsci.org)
- The first successful treatment for mucopolysaccharidoses was bone marrow transplantation, which was introduced for the therapy in 1980. (news-medical.net)
- Hematopoietic stem cell transplantation (HSCT) has been used in patients with mucopolysaccharidosis in order to correct the enzyme-deficiency. (news-medical.net)
- Intra-bone marrow bone marrow transplantation (IBM-BMT) can replace not only hemopoietic stem cells (HSCs) but also MSCs. (omicsonline.org)
- Safety and Role of Gastrointestinal Endoscopy in the Management of Gastrointestinal Acute GVHD in Children After Hematopoietic Stem Cell Transplantation. (stembook.org)
- Safety of ruxolitinib therapy prior to allogeneic hematopoietic stem-cell transplantation for myeloproliferative neoplasms. (stembook.org)
- He served 20 years in the Navy where he was involved in transplantation, tissue and blood banking He retired in 2007 as COO at the Puget Sound Blood Center where he founded the Northwest Tissue Center in 1988. (fda.gov)
- The LMWH/P N/MPs, in combination with ADSCs or BMSCs, are effective cell-carriers and are potential promising novel therapeutic agents for inducing vascularization and fibrous tissue formation in ischemic disease by transplantation of the ADSCs and LMWH/P N/MPs-aggregates. (mdpi.com)
- Dr Keating is an internationally recognized leader in blood and marrow transplantation and cell therapy. (lww.com)
- He is a Professor of Medicine and of Biomedical Engineering and was the Director, Division of Hematology for almost two decades at the University of Toronto, Ontario, Canada and the first incumbent of the Epstein Chair in Cell Therapy and Transplantation. (lww.com)
- He established what has become the largest stem cell transplantation program in Canada at University Health Network, Toronto, Ontario, Canada and the Princess Margaret Cancer Centre, Ontario, Canada. (lww.com)
- Both in vitro and in vivo , they can differentiate into cartilage, bone, tendons and fat cells, and-in contrast to embryonic stem cells-they are not under ethical scrutiny. (eurekaselect.com)
- Stem cells (SCs) are a unique type of cells characterized by the ability to (i) self‐renewal through unlimited cell divisions and (ii) differentiate into other types of specialized cells, including epithelial, muscle, neuronal cells and others [ 5 , 6 ]. (intechopen.com)
- Although adult stem cells are generally known to generate the cell types of the tissue in which they reside, mesenchymal stem cells (MSCs) are unique in that they differentiate not only into the same mesodermal-lineage such as bone, cartilage, and adipocytes, but also into other lineages of ectodermal and endodermal cells. (elsevier.com)
- Furthermore, a subpopulation of MSCs are known to integrate into damaged sites, differentiate into cell types specific to the integrated tissue and contribute to the tissue repair. (elsevier.com)
- Recent evidence suggests that a subpopulation of human MSCs, which were named Muse cells, were shown to have the ability to differentiate into trilineage cells and to function as tissue repairing cells in vivo. (elsevier.com)
- Mesenchymal stem cells (MSCs) are an appealing autologous way to obtain somatic stem cells for cell-based bone tissue regenerative therapy, because they proliferate in vitro and differentiate into bone tissue cells [1C5] actively. (buyresearchchemicalss.net)
- They can differentiate into various specialized cell types under certain physiological or experimental conditions. (nature.com)
- Stem cells are undifferentiated cells that can differentiate into a variety of cell types. (bvsalud.org)
- To promote biomaterial vascularization, a number of strategies have been developed by using ( i ) growth factors that induce endothelial cell (EC) migration and proliferation ( 9 ⇓ - 11 ) and ( ii ) ECs or stem cells that can differentiate toward the endothelial lineage ( 12 , 13 ). (pnas.org)
- They filled the scaffold with human mesenchymal progenitors (stem cells that can differentiate into many cell types) and then applied the patches to damaged heart tissue . (medicalxpress.com)
- A highly useful feature of Muse cells is their specific ability to detect damage signals, which allows them to migrate toward and home into damaged tissues when infused into the peripheral blood stream where they can spontaneously differentiate into cells compatible with the homed-into tissue. (selectbiosciences.com)
- Stem cells are different from other cells of the body in that they have the ability to differentiate into other cell/tissue types. (slideshare.net)
- Examining the ability of these cells to proliferate and differentiate in a whole kidney extracellular matrix scaffold would serve as a valuable baseline for future studies in producing a functioning organ. (ufl.edu)
- Adipose tissue-derived stem cells (ASC) can differentiate to various kinds of cells including vascular cells. (nii.ac.jp)
- they have the potential to give rise to an entire organism and to differentiate to all cell lineages ( 2 ). (aacrjournals.org)
- MSC are multipotent cells with many potential clinical applications due to their capacity to be expanded ex vivo and to differentiate into several lineages, including osteocytes, chondrocytes, myocytes, and adipocytes. (aacrjournals.org)
- Although adipose tissue-derived MSCs and bone marrow-derived MSCs (BMMSCs) show the same immunoregulatory functions and support of hematopoiesis [ 36 ], BMMSCs have a higher degree of commitment to differentiate into chondrogenic and osteogenic lineages than adipose tissue-derived MSCs [ 37 ]. (omicsonline.org)
- The principal biochemical and biological characteristics of the collagen-based biomaterials are presented, including their interactions with cells (fibroblasts), distinct from those of synthetic polymers, and their potential use in gene therapy through the formation of neo-organs or organoids. (nih.gov)
- Biomaterials, such as ceramics and metals, are already used as implants to replace or improve the functionality of the damaged tissue or organ. (intechopen.com)
- Moreover, biomaterials may enhance the SCs biological activity and their implementation by establishing a specific microenvironment mimicking natural cell niche. (intechopen.com)
- Thus, the synergistic advancement in the fields of biomaterial and medical sciences constitutes a challenge for the development of effective therapies in humans including combined applications of novel biomaterials and SCs populations. (intechopen.com)
- Adhesion of Cells to Biomaterials. (wiley.com)
- Biomaterials have been the focus of materials for use in tissue engineering, as traditional biomaterials or development of tissue engineering-specific variants. (scielo.br)
- While the operating room is often the stage where innovations in tissue engineering and regenerative medicine are realized, as surgeons use grafted tissues, novel biomaterials, and new approaches to perform breast, chest and abdominal wall, and pelvic floor reconstruction, new FDA draft guidelines would place even tighter restrictions on surgical practice and may limit the development of new therapies. (news-medical.net)
- Plasma-based biomaterials for the treatment of cutaneous radiation injury. (osu.edu)
- In the presence of just four genes (identified because they are highly expressed by embryonic stem cells), they can assume the characteristics of embryonic stem cells and, under the right conditions, can become nearly any cell type. (medindia.net)
- Pluripotent, embryonic stem cells originate as inner cell mass (ICM) cells within a blastocyst. (slideshare.net)
- However, one advantage of EG cells is that they do not appear to generate tumours when transferred into the body, as embryonic stem cells do. (slideshare.net)
- Stem cells can be derived from several sources, including embryonic stem cells, fetal stem cells, hematopoietic stem cells, mesenchymal stem cells, adult stem cells and induced pluripotent stem cells. (aao.org)
- Pluripotent embryonic stem cells are highly proliferative, capable of differentiating into all cells of the kidney, and respond to tissue-specific extracellular matrix proteins. (ufl.edu)
- Geron focuses on human embryonic stem cells (hESCs). (genengnews.com)
- Some current methods generate embryonic stem cells using a fertilized egg. (genengnews.com)
- 2 Several issues have been raised against harvesting human embryonic stem cells. (ahajournals.org)
- 3 Compared with embryonic stem cells, autologous adult stem cells do not raise any major ethical or immunologic problems. (ahajournals.org)
- About Cord Blood Association: The Cord Blood Association will be an international nonprofit organization that promotes the banking and use of umbilical cord blood and related tissues for disease treatment and regenerative therapies. (prweb.com)
- The ISSCR supports the increase in biomedical research funding in the 21st Century Cures Act in the U.S. It also underscores concern that the bill's streamlined process for FDA review and approval of regenerative therapies include a rigorous review of scientific and clinical evidence to ensure safety and efficacy. (isscr.org)
Engineering and regenerative medicine3
- Adipose tissue is now recognized as an accessible, abundant, and reliable site for the isolation of adult stem cells suitable for tissue engineering and regenerative medicine applications. (seattlestemcellcenter.net)
- In particular, the discovery of induced pluripotent stem cells (iPSCs) in 2006 catalyzed the fields of tissue engineering and regenerative medicine as they represented a major advance in stem cell technology [ 4 ]. (iospress.com)
- Chapter 1 from Translational Approaches in Tissue Engineering and Regenerative Medicine,Jeremy J. Mao, Gordana Vunjak-Novakovic, Antonios G. Mikos, Anthony Atala, Editors Publisher: Artech House Publishers Illustration: N Language: ENG Title: Tis. (tradebit.com)
- cell lineages characterizes MSCs as pluripotent cells, suggesting that the term `mesenchymal' stem cell might be inappropriate to describe this particular stem cell. (biologists.org)
- Right here, we built multilayered mesenchymal cell (MLMCs) sheet anchored to collagen-binding bFGF utilizing a book cell tissue anatomist technique. (buyresearchchemicalss.net)
- ES cells can give rise to almost all cell lineages and are the most promising cells for regenerative medicine. (nature.com)
- MSCs, also called mesenchymal stromal cells, are a subset of non-hematopoietic adult stem cells that originate from the mesoderm. (nature.com)
- For example, when companies use primary adult stem cells, costs can be huge. (genengnews.com)
- Human adult stem cells are being evaluated widely for various therapeutic approaches. (aacrjournals.org)
- The clear similarities between stem cell and cancer stem cell genetic programs are nonetheless the basis of a recent proposal that some cancer stem cells could derive from human adult stem cells. (aacrjournals.org)
- This is the first report of spontaneous transformation of human adult stem cells, supporting the hypothesis of cancer stem cell origin. (aacrjournals.org)
- Mesenchymal stem cells (MSCs) are prototypical adult stem cells, identified as an adherent, fibroblast-like population positive for CD105, CD90 and CD73, and lacking hematopietic markers. (omicsonline.org)
- Broadly speaking," states Thomas B. Okarma, Ph.D., M.D., president, CEO, and director of Geron (www.geron.com), "the cost of goods is among the most critical issues for biomanufacturing cellular therapies. (genengnews.com)
- Its subsidiaries - the South Texas Blood & Tissue Center, QualTex Laboratories, GenCure and The Blood & Tissue Center Foundation - provide products used in regenerative medicine treatment and research, including cellular therapies, umbilical cord blood and tissue services, as well as testing of blood and plasma products for clients in the United States and worldwide. (prweb.com)
- Hematopoietic stem cells (HSCs) have been widely used for allogeneic cell therapy. (nature.com)
- Mouse hematopoietic stem cells. (springer.com)
- The progressive increases of corrected versus non-corrected peripheral blood leukocytes indicate the potential of RP-L102 to restore the functionality of bone marrow hematopoietic stem cells. (benzinga.com)
- Safety of Living Donation of Hematopoietic Stem Cells. (stembook.org)
- Recently, bFGF-PKD-CBD was proven to enhance bone tissue formation at lower concentrations than bFGF alone when order Vitexin packed onto implantable collagen bed sheets [28, 29], recommending that the procedure mix of bFGF-PKD-CBD and a multilayered cell build comprising MSCs may promote ectopic bone tissue formation at defect sites. (buyresearchchemicalss.net)
- Mesenchymal stem cells (MSCs), the major stem cells for cell therapy, have been used in the clinic for approximately 10 years. (nature.com)
- From animal models to clinical trials, MSCs have afforded promise in the treatment of numerous diseases, mainly tissue injury and immune disorders. (nature.com)
- Although MSCs for cell therapy have been shown to be safe and effective, there are still challenges that need to be tackled before their wide application in the clinic. (nature.com)
- Due to the limitation of using ES and iPS cells in the clinic, great interest has developed in mesenchymal stem cells (MSCs), which are free of both ethical concerns and teratoma formation. (nature.com)
- MSCs exist in almost all tissues. (nature.com)
- A group of researchers at Osaka University developed a synthetic tissue using synovium-derived mesenchymal stem cells (MSCs) for treating damaged cartilage, which had previously been incurable and had no effective therapies. (medicalxpress.com)
- The systematic isolation of MSCs from different organs and tissues and the evaluation of their characteristics could represent an alternative approach. (biologists.org)
- MSCs can be isolated from different adult tissues including bone marrow (BM), umbilical cord, skeletal muscle and adipose tissue . (omicsonline.org)
- MSCs have been shown to modulate immunological responses via T-cell suppression [ 24 , 26 - 28 ]. (omicsonline.org)
- Adipose tissue and BM are the most readily available sources of MSCs because they are easy to harvest, and because of their relative abundance of progenitors and the lack of ethical concerns. (omicsonline.org)
- These results indicate that periodontal ligament tissue remaining on the root surface after a tooth extraction contains undifferentiated cells that have the ability to regenerate alveolar bone. (nii.ac.jp)
- There are some human organs and tissues that regenerate rather than simply scar, as a result of injury. (wikipedia.org)
- The aim for these techniques is to be used in the near future to regenerate any tissue in the human body. (wikipedia.org)
- Therefore, to regenerate hollow organs and tissues with a long diffusion distance, the tissue had to be regenerated inside the lab, via the use of a 3D printer. (wikipedia.org)
- Next, they mined the essential factors produced by the cells that send the signal to regenerate new tissue. (healthcanal.com)
- The goals of this emerging field are to replace, repair, or regenerate tissues and organs. (genengnews.com)
- It is an interdisciplinary field combining many techniques that aim to maintain, regenerate or replace a tissue or organ. (scielo.br)
- Tissue engineering is a set of biomedical, biotechnological and engineering techniques that aim to maintain, regenerate or replace tissues or organs. (scielo.br)
- Perinatal Tissue-Derived Stem Cells: Alternative Sources of Fetal Stem Cells, part of Springer's Stem Cell Biology and Regenerative Medicine series, is essential reading for basic and clinical scientists, clinicians, and pharmaceutical experts working or conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, and cellular therapy. (springer.com)
- According to the Royan Institute for stem cell biology and technology, Iran is one of the most pioneering countries in the world and the second country in the region in terms of stem cell knowledge and technology. (tehrantimes.com)
- SCTM is an international peer-reviewed journal, publishing articles focused on advancing the clinical utilization of stem cell molecular and cellular biology. (prweb.com)
- About STEM CELLS Translational Medicine: STEM CELLS Translational Medicine (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. (prweb.com)
- Our findings indicate the importance of biosafety studies of mesenchymal stem cell biology to efficiently exploit their full clinical therapeutic potential. (aacrjournals.org)
- He has conducted laboratory, translational and clinical research in these areas, particularly on the biology and clinical application of mesenchymal stromal cells and NK cells. (lww.com)
- Dr Spitalnik is currently the Executive Vice-Chair and has been a Professor in the Department of Pathology & Cell Biology at Columbia University, New York, USA since 2003. (lww.com)
- The potential and challenges for developing clinical therapies based on these approaches will be discussed. (aiche.org)
- Biomaterial sciences and tissue engineering approaches are currently fundamental strategies for the development of regenerative medicine. (intechopen.com)
- One of the fundamental principles underlying tissue engineering approaches is that newly formed tissue must maintain sufficient vascularization to support its growth. (pnas.org)
- The hype is well-earned because of the potential of stem cells to contribute to disease modeling, drug screening, and even therapeutic approaches. (frontiersin.org)
- New approaches to engineering tissues, such as 3D bioprinting, are described as they provide exciting opportunities for future work along with current challenges that must be addressed. (iospress.com)
- 2 Trials of stem cell therapy have taken several approaches. (aao.org)
- 2019. Designing stem-cell-based dopamine cell replacement trials for Parkinson's disease . (cardiff.ac.uk)
- The application of ASCs and SVF cells is still in its infancy and the field has made progressive advances towards clinical applications. (seattlestemcellcenter.net)
- For each of these research domains, we will describe recent advances in hPSCs culture and we will focus on the clinical relevance of using hPSCs for in vitro nervous system disease modeling and therapies. (frontiersin.org)
- peer-reviewed publications were screened for relevance in order to identify key advances in stem and progenitor cell contribution to the field of bone tissue engineering. (springer.com)
- As the field of regenerative medicine endeavors to harness the body's own cells for treatment, scientific innovation has led to great advances in stem cell-based therapies in the past decade. (springer.com)
- Recent advances in cell therapies and tissue engineering are paving the road to regenerative medicine. (genengnews.com)
- In this review, we summarize the advances in understanding the behavior of human corneal endothelial cells, their current engineering strategy in vitro and their potential applications. (medsci.org)
- Retinal pigmented epithelial cells and photoreceptors derived from these are some of the most promising cells that may soon be used in the treatment of specific HMD, especially since rapid developments in the field of induced pluripotency have now set the stage for the production of patient-derived stem cells that overcome the ethical and methodological issues surrounding the use of embryonic derivatives. (nih.gov)
- Stem cells in epithelial tissues. (springer.com)
- Cytokeratin is an epithelial cell marker and Pax-2 is necessary for kidney development. (ufl.edu)
- Examples include epithelial stem cells in epidermis and intestinal crypts ( Slack, 2000 ), neural stem cells in the central nervous system ( McKay, 1997 ) and satellite cells in muscle ( Charge and Rudnicki, 2004 ). (biologists.org)
- Electrical Activity in Cardiac Tissue, Modeling of. (wiley.com)
- They are also studying how the cells within such a cardiac patch, when implanted on infarcted heart tissue, develop their ability to generate mechanical force and electrical conduction, and how these functions can be modulated by in-vitro culture. (medicalxpress.com)
- Cardiac Mesenchymal Cells from Failing and Non-Failing Hearts Limit Ventricular Dilation when Administered Late after Infarction. (aau.dk)
- NBS10 is thought to work by increasing microvascular blood flow in the heart muscle via the development and formation of new blood vessels, thereby reversing the restriction of blood supply caused by a heart attack and rescuing at-risk cardiac tissue from eventual cell death. (cnbc.com)
- The main approach of cardiac tissue engineering is to create cardiac grafts, either whole heart substitutes or tissues that can be efficiently implanted in the organism, regenerating the tissue and giving rise to a fully functional heart, without causing side effects, such as immunogenicity. (scielo.br)
- BM chimerism with Sca-1+ cells in aged mice restored the regenerative capability of cardiac resident progenitors and improved functional healing of the aged heart. (ahajournals.org)
- Restoration of the Sca-1 subset of stem cells by BM reconstitution improved cardiac repair and prevented heart failure. (ahajournals.org)
- Current hypotheses of mechanisms of myoblast actions include limitation of left ventricular remodeling, as well as paracrine effects determining angiogenesis, recruitment of resident quiescent cardiac cells, and extracellular matrix stabilization. (ahajournals.org)
- DUBLIN--( BUSINESS WIRE )-- The "FDA's Regulation of Regenerative Medicine including Stem Cell Treatments, Tissue Engineering and Gene Therapies: 2-Day In-person Seminar" conference has been added to Research And Markets' offering. (biospace.com)
- For questions on the content of this guidance, contact the Division of Human Tissues, Office of Cellular, Tissue and Gene Therapies at 301-827-2002. (vegsource.com)
- The key benefit of ATMP classification is the early involvement and guidance from the EMA's Committee of Advanced Therapies, which is the regulatory reviewing body for gene therapies. (benzinga.com)
- Human adipose tissue is a source of multipotent stem cells. (springer.com)
- Following the blastocyst stage, the tissues of the embryo start to form and the cells become multipotent. (slideshare.net)
- 23-26 There is much confusion in the literature when using terms describing multipotent stem cells from the adipose tissue stroma. (ahajournals.org)
Bone marrow derived4
- One approach is a subretinal or intravitreal injection of bone marrow derived or human embryonic tissue derived stem cells. (aao.org)
- Bone marrow-derived human mesenchymal stem cells (hMSCs) and human embryonic stem cell-derived cells (hESdCs) were modified with angiogenic factor (VEGF) DNA by using poly(β-amino esters), a family of hydrolytically biodegradable polymers that can condense DNA to form nanoparticles ( 14 ). (pnas.org)
- However, the relatively low abundance, small tissue volume, difficult accessibility, and disease-related malfunction of bone marrow-derived stem cells hamper their clinical usefulness. (ahajournals.org)
- Low molecular weight heparin (LMWH)/protamine (P) nano/micro particles (N/MPs) (LMWH/P N/MPs) were applied as carriers for heparin-binding growth factors (GFs) and for adhesive cells including adipose-derived stromal cells (ADSCs) and bone marrow-derived mesenchymal stem cells (BMSCs). (mdpi.com)
- However, in spite of numerous statements in the social media declaring that these cells can be used in medicine for therapeutic purposes, the clinical applications remain few ( Aznar and Sanchez, 2011 ). (frontiersin.org)
- The ability to transfer SP cells and create Trm cells to boost the immune system against a patient's cancer could be of therapeutic benefit and needs to be further investigated," explained Dr. Chandra Sekhar Boddupalli, a post-doctoral associate in the Dhodapkar lab and first author of the paper. (scitechdaily.com)
- The text provides a brief review of each type of perinatal stem cells and then focuses on their multi- or pluripotent properties, regenerative capacity, and future therapeutic potential in regenerative medicine. (springer.com)
- But researchers and clinicians have been cautious about promoting potential therapeutic uses for these cells because the insertion of the genes could render the cells cancerous. (medindia.net)
- These results indicate that stem cells engineered with biodegradable polymer nanoparticles may be therapeutic tools for vascularizing tissue constructs and treating ischemic disease. (pnas.org)
- However, previous studies have largely relied on viral vectors to deliver these therapeutic genes to stem cells, which are associated with safety concerns. (pnas.org)
- Cell therapy goes way beyond the therapeutic reach of a pill, and we will see cost containment in this field for the first time. (genengnews.com)
- The therapeutic use of human cell and tissue products is highly regulated by the U.S. government, but a specific exception allows surgeons to harvest, manipulate, and implant tissues in many commonly performed procedures. (news-medical.net)
- It is made in yeast, a relative outsider in the world of therapeutic protein manufacturing, which is dominated by bacteria and mammalian cell culture. (technologyreview.com)
- The B-Cell Lymphoma Moon Shot is revolutionizing the conventional medical research approach to rapidly translate findings into patient treatment options and develop personalized therapeutic strategies. (mdanderson.org)
- While the concept of using polymer-based sustained-release delivery systems to maintain therapeutic concentration of protein drugs for extended periods of time has been well accepted for decades, there has not been a single product in this category successfully commercialized to date despite clinical and market demands. (pubmedcentralcanada.ca)
- The biocompatibility of surgically implanted foreign biomaterial refers to the interactions between the biomaterial and the host body tissue. (wikipedia.org)
- With cells from another individual (allogeneic) or another species (xenogeneic), encapsulation in semipermeable barriers improves immune acceptance, as it inhibits passage of antibodies and excludes cytotoxic cells of the host. (aiche.org)
- Adoptive cellular therapy uses the body's own T cells to boost its immune system to target cancer. (scitechdaily.com)
- B7-H3 preferentially down-regulated T H 1-mediated immune response in B7-H3-deficient mice ( 5 ), and 4Ig-B7-H3 inhibited natural killer (NK) cell-mediated lysis of neuroblastoma cells by interacting with a putative inhibitory receptor on the surface of NK cells ( 6 ). (aacrjournals.org)
- Because the cells activate an immune response similar to inflammation in the presence of viral genetic material, the researchers termed the process "transflammation. (medindia.net)
- These might provide a clue of the potential immune based therapy strategy for ESCC patients. (springer.com)
- 2018. Outcome of cell suspension allografts in a patient with Huntington's disease . (cardiff.ac.uk)
- RCKT ) ("Rocket"), a leading U.S.-based multi-platform gene therapy company, today reported financial results for the quarter ended June 30, 2018, and provided an update on the Company's recent achievements, as well as upcoming milestones. (benzinga.com)
- In May 2018, Rocket and the Stanford University School of Medicine announced a strategic collaboration to support the advancement of FA and PKD gene therapy research. (benzinga.com)
- At the present time, adult SCs isolated from postnatal tissues are widely used in clinical applications. (intechopen.com)
- Based on the origin and source of isolation, SCs may be included in two main groups: (i) embryonic SCs (ESCs)-derived from embryos at different stages of development and (ii) adult SCs (ASCs)-isolated from several postnatal and adult tissue sources, including the umbilical cord, cord blood, bone marrow, adipose tissue, central nervous system, retina, skeletal muscle and other mature tissues [ 7 , 8 ]. (intechopen.com)
- The successful isolation of pluripotent embryonic stem (ES) cells from the inner cell mass of early embryos has provided a powerful tool for biological research. (nature.com)
- The ethical issues related to their isolation have promoted the development of induced pluripotent stem (iPS) cells, which share many properties with ES cells without ethical concerns. (nature.com)
- Our goal was achieved by isolation and transfection of adipose-derived stromal cells (ADSCs) with adenovirus encoding the cDNA of VEGF. (pnas.org)
- Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood. (semanticscholar.org)
- Stem cells are promising therapeutics for revascularization because of their capability of self-renewal, relative ease of isolation, and ability to migrate toward the ischemic tissues ( 4 ). (pnas.org)
- Isolation of adipose tissue-derived mesenchymal stem cell. (aacrjournals.org)
- Isolation and nomenclature of adipose tissue-derived cells. (ahajournals.org)
Human cells and tissues1
- About GenCure: GenCure, a Texas nonprofit corporation, focuses on regenerative medicine and uses the power of human cells and tissues to inspire hope, enhance lives and enable clinical advancements. (prweb.com)
- Published definition of the cell identity with a panel of surface antigens and establishment of universally applied quality assurance/ quality control testing criteria would benefit the fledgling adipose stem cell community. (seattlestemcellcenter.net)