Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.
Adherence of cells to surfaces or to other cells.
Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (ANTIGENS, CD56); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
A publication issued at stated, more or less regular, intervals.
A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.
A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Progenitor cells from which all blood cells derive.
Cell adhesion molecule and CD antigen that mediates neutrophil, monocyte, and memory T-cell adhesion to cytokine-activated endothelial cells. E-selectin recognizes sialylated carbohydrate groups related to the Lewis X or Lewis A family.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The nonstriated involuntary muscle tissue of blood vessels.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
A family of immunoglobulin-related cell adhesion molecules that are involved in NERVOUS SYSTEM patterning.
The scientific disciplines concerned with the embryology, anatomy, physiology, biochemistry, pharmacology, etc., of the nervous system.
Spiny processes on DENDRITES, each of which receives excitatory input from one nerve ending (NERVE ENDINGS). They are commonly found on PURKINJE CELLS and PYRAMIDAL CELLS.
Transmembrane proteins consisting of a lectin-like domain, an epidermal growth factor-like domain, and a variable number of domains that are homologous to complement regulatory proteins. They are important cell adhesion molecules which help LEUKOCYTES attach to VASCULAR ENDOTHELIUM.
Alterations or deviations from normal shape or size which result in a disfigurement of the hand.

Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta. (1/9582)

Trophinin, tastin, and bystin comprise a complex mediating a unique homophilic cell adhesion between trophoblast and endometrial epithelial cells at their respective apical cell surfaces. In this study, we prepared mouse monoclonal antibodies specific to each of these molecules. The expression of these molecules in the human placenta was examined immunohistochemically using the antibodies. In placenta from the 6th week of pregnancy, trophinin and bystin were found in the cytoplasm of the syncytiotrophoblast in the chorionic villi, and in endometrial decidual cells at the utero placental interface. Tastin was exclusively present on the apical side of the syncytiotrophoblast. Tissue sections were also examined by in situ hybridization using RNA probes specific to each of these molecules. This analysis showed that trophoblast and endometrial epithelial cells at the utero placental interface express trophinin, tastin, and bystin. In wk 10 placenta, trophinin and bystin were found in the intravillous cytotrophoblast, while tastin was not found in the villi. After wk 10, levels of all three proteins decreased and then disappeared from placental villi.  (+info)

Mycophenolate mofetil prevents the progressive renal failure induced by 5/6 renal ablation in rats. (2/9582)

BACKGROUND: Extensive renal ablation is associated with progressive sclerosis of the remnant kidney. Because lymphocytes and monocytes accumulate in the remnant kidney, it is likely that they play a role in the renal scarring. Therefore, we treated rats with 5/6 nephrectomy (5/6Nx) with mycophenolate mofetil (MMF), a drug that has an antiproliferative effect and that suppresses the expression of intercellular adhesion molecules. METHODS: Sprague-Dawley rats with 5/6Nx received MMF (30 mg. kg-1. day-1 by daily gastric gavage, N = 15) or vehicle (N = 16). Ten additional rats were sham operated. All rats were fed a 30% protein diet. Body weight, serum creatinine, and urinary protein excretion were determined weekly. Lipid peroxidation, as a measure of oxidative stress observed by urinary malondialdehyde determinations, was performed every two weeks. Histologic studies were done in the remnant kidney four weeks (9 rats from the vehicle-treated group, 7 rats from the MMF group, and 5 sham-operated rats) and eight weeks after surgery (the remaining rats). Glomerular volume, sclerosis in glomeruli (segmental and global) and interstitium (semiquantitative scale), infiltrating lymphocytes and macrophages (CD43- and ED1-positive cells), and expression of adhesion molecules (CD54, CD18, and CD11b) were analyzed. RESULTS: MMF treatment prevented the progressive increment in serum creatinine and the proteinuria observed in the 5/6 nephrectomized rats during the eight weeks of observation (P < 0.01). Weight gain was comparable in the MMF-treated and sham-operated rats, whereas weight gain was decreased in untreated 5/6 nephrectomized rats. Excretion of malondialdehyde increased after surgery but returned sooner to control levels in the MMF-treated rats. Increments in glomerular size and mean arterial blood pressure induced by renal ablation were not modified by MMF treatment. Eight weeks after surgery, segmental sclerosis was present in 48.4 +/- 8.35% (+/- sd) glomeruli in the vehicle-treated group versus 25 +/- 10.5% in the MMF-treated group (P < 0.001). Interstitial fibrosis was reduced significantly with MMF treatment (P < 0.001). Infiltration with CD43- and ED1-positive cells in glomeruli and interstitium was two to five times lower in MMF-treated rats (P < 0.01). Expression of adhesion molecules CD18 and CD11b was similarly reduced. CONCLUSION: MMF ameliorates the progressive renal damage in the remnant kidney after 5/6Nx. This effect is associated with a reduction in the infiltration of lymphocytes and monocytes, whereas glomerular hypertrophy and systemic hypertension are unchanged.  (+info)

A cell-surface superoxide dismutase is a binding protein for peroxinectin, a cell-adhesive peroxidase in crayfish. (3/9582)

Peroxinectin, a cell-adhesive peroxidase (homologous to human myeloperoxidase), from the crayfish Pacifastacus leniusculus, was shown by immuno-fluorescence to bind to the surface of crayfish blood cells (haemocytes). In order to identify a cell surface receptor for peroxinectin, labelled peroxinectin was incubated with a blot of haemocyte membrane proteins. It was found to specifically bind two bands of 230 and 90 kDa; this binding was decreased in the presence of unlabelled peroxinectin. Purified 230/90 kDa complex also bound peroxinectin in the same assay. In addition, the 230 kDa band binds the crayfish beta-1,3-glucan-binding protein. The 230 kDa band could be reduced to 90 kDa, thus showing that the 230 kDa is a multimer of 90 kDa units. The peroxinectin-binding protein was cloned from a haemocyte cDNA library, using immuno-screening or polymerase chain reaction based on partial amino acid sequence of the purified protein. It has a signal sequence, a domain homologous to CuZn-containing superoxide dismutases, and a basic, proline-rich, C-terminal tail, but no membrane-spanning segment. In accordance, the 90 and 230 kDa bands had superoxide dismutase activity. Immuno-fluorescence of non-permeabilized haemocytes with affinity-purified antibodies confirmed that the crayfish CuZn-superoxide dismutase is localized at the cell surface; it could be released from the membrane with high salt. It was thus concluded that the peroxinectin-binding protein is an extracellular SOD (EC-SOD) and a peripheral membrane protein, presumably kept at the cell surface via ionic interaction with its C-terminal region. This interaction with a peroxidase seems to be a novel function for an SOD. The binding of the cell surface SOD to the cell-adhesive/opsonic peroxinectin may mediate, or regulate, cell adhesion and phagocytosis; it may also be important for efficient localized production of microbicidal substances.  (+info)

Interaction of lipopolysaccharide with human small intestinal lamina propria fibroblasts favors neutrophil migration and peripheral blood mononuclear cell adhesion by the production of proinflammatory mediators and adhesion molecules. (4/9582)

Fibroblasts are important effector cells having a potential role in augmenting the inflammatory responses in various diseases. In infantile diarrhea caused by enteropathogenic Escherichia coli (EPEC), the mechanism of inflammatory reactions at the mucosal site remains unknown. Although the potential involvement of fibroblasts in the pathogenesis of cryptococcus-induced diarrhea in pigs has been suggested, the precise role of lamina propria fibroblasts in the cellular pathogenesis of intestinal infection and inflammation caused by EPEC requires elucidation. Earlier we reported the lipopolysaccharide (LPS)-induced cell proliferation, and collagen synthesis and downregulation of nitric oxide in lamina propria fibroblasts. In this report, we present the profile of cytokines and adhesion molecules in the cultured and characterized human small intestinal lamina propria fibroblasts in relation to neutrophil migration and adhesion in response to lipopolysaccharide (LPS) extracted from EPEC 055:B5. Upon interaction with LPS (1-10 micrograms/ml), lamina propria fibroblasts produced a high level of proinflammatory mediators, interleukin (IL)-1alpha, IL-1beta, IL-6, IL-8, tumor necrosis factor (TNF)-alpha and cell adhesion molecules (CAM) such as intercellular cell adhesion molecule (ICAM), A-CAM, N-CAM and vitronectin in a time-dependent manner. LPS induced cell-associated IL-1alpha and IL-1beta, and IL-6, IL-8 and TNF-alpha as soluble form in the supernatant. Apart from ICAM, vitronectin, A-CAM, and N-CAM proteins were strongly induced in lamina propria fibroblasts by LPS. Adhesion of PBMC to LPS-treated lamina propria fibroblasts was ICAM-dependent. LPS-induced ICAM expression in lamina propria fibroblasts was modulated by whole blood, PBMC and neutrophils. Conditioned medium of LPS-treated lamina propria fibroblasts remarkably enhanced the neutrophil migration. The migration of neutrophils was inhibited by anti-IL-8 antibody. Co-culture of fibroblasts with neutrophils using polycarbonate membrane filters exhibited time-dependent migration of neutrophils. These findings indicate that the coordinate production of proinflammatory cytokines and adhesion molecules in lamina propria fibroblasts which do not classically belong to the immune system can influence the local inflammatory reactions at the intestinal mucosal site during bacterial infections and can influence the immune cell population residing in the lamina propria.  (+info)

CD28 ligation induces tyrosine phosphorylation of Pyk2 but not Fak in Jurkat T cells. (5/9582)

Protein tyrosine kinases are critical for the function of CD28 in T cells. We examined whether the tyrosine kinases Pyk2 and Fak (members of the focal adhesion kinase family) are involved in CD28 signaling. We found that ligating CD28 in Jurkat T cells rapidly increases the tyrosine phosphorylation of Pyk2 but not of Fak. Paxillin, a substrate for Pyk2 and Fak, was not tyrosine-phosphorylated after CD28 ligation. CD28-induced tyrosine phosphorylation of Pyk2 was markedly reduced in the absence of external Ca2+. Previous studies have shown that the T cell antigen receptor (TCR) induces tyrosine phosphorylation of Pyk2. In this report, the concurrent ligation of CD28 and TCR increased tyrosine phosphorylation of Pyk2; however, the extent of phosphorylation by both receptors was equivalent to the sum of that induced by each receptor alone. The Syk/Zap inhibitor piceatannol blocked CD28, and TCR induced tyrosine phosphorylation of Pyk2, suggesting that Syk/Zap is involved in Pyk2 phosphorylation. In contrast, the phosphatidylinositol 3-kinase inhibitor wortmannin blocked TCR- but not CD28-induced phosphorylation of Pyk2, suggesting that CD28 and TCR activate distinct pathways to induce tyrosine phosphorylation of Pyk2. Notably, depleting phorbol 12-myristate 13-acetate-sensitive protein kinase C did not block CD28- and CD3-induced tyrosine phosphorylation of Pyk2. These data provide evidence for the involvement of Pyk2 in the CD28 signaling cascade and suggest that neither Fak nor paxillin is involved in the signaling pathways of CD28.  (+info)

Similarities and differences in RANTES- and (AOP)-RANTES-triggered signals: implications for chemotaxis. (6/9582)

Chemokines are a family of proinflammatory cytokines that attract and activate specific types of leukocytes. Chemokines mediate their effects via interaction with seven transmembrane G protein-coupled receptors (GPCR). Using CCR5-transfected HEK-293 cells, we show that both the CCR5 ligand, RANTES, as well as its derivative, aminooxypentane (AOP)- RANTES, trigger immediate responses such as Ca2+ influx, receptor dimerization, tyrosine phosphorylation, and Galphai as well as JAK/STAT association to the receptor. In contrast to RANTES, (AOP)-RANTES is unable to trigger late responses, as measured by the association of focal adhesion kinase (FAK) to the chemokine receptor complex, impaired cell polarization required for migration, or chemotaxis. The results are discussed in the context of the dissociation of the late signals, provoked by the chemokines required for cell migration, from early signals.  (+info)

Expression of intercellular adhesion molecules ICAM-1 and ICAM-2 in human endometrium: regulation by interferon-gamma. (7/9582)

The purpose of this study was to localize intercellular adhesion molecule (ICAM)-1 and ICAM-2 in human endometrium and myometrium throughout the menstrual cycle, and to determine whether the expression of these molecules is regulated by interferon (IFN)-gamma. ICAM-1 and ICAM-2 distribution was examined in endometrial biopsies by immunocytochemistry, and Northern blotting was used to quantify ICAM-1 and ICAM-2 mRNA expression in isolated endometrial glands. Stromal fibroblast cultures were exposed to IFN-gamma and the effect on expression of ICAM-1 and ICAM-2 was determined by immunocytochemistry and Northern blotting. ICAM-1 was localized in vivo to the apical surface of the glandular epithelium, the vascular endothelium and endometrial stromal cells throughout the menstrual cycle. Stromal expression of ICAM-1 was up-regulated in menstrual specimens. Northern blotting confirmed the presence of ICAM-1 mRNA in isolated endometrial glands. The expression of ICAM-1 antigen and message was increased in stromal cell culture after incubation with IFN-gamma in a time-dependent manner, suggesting that this cytokine stimulates the expression of ICAM-1 in the endometrial stroma. ICAM-2 antigen expression was restricted to the vascular endothelium. ICAM-2 mRNA was absent in endometrial glands. The widespread distribution of ICAM-1 in human endometrium suggests that this molecule is involved in the process of menstruation, the functioning of glands, blood vessels and stroma, and in regulating leukocyte trafficking into the tissue. ICAM-2 is restricted to the vascular endothelium where it might modulate leukocyte invasion of the stroma and myometrial connective tissue.  (+info)

Characterization of prethymic progenitors within the chicken embryo. (8/9582)

The thymic primordium in both birds and mammals is first colonized by cells emerging from the intra-embryonic mesenchyme but the nature of these precursors is poorly understood. We demonstrate here an early embryonic day 7 prethymic population with T lymphoid potential. Our work is a phenotypic analysis of, to date, the earliest embryonic prethymic progenitors arising in the avian para-aortic area during ontogeny. The phenotype of these cells, expressing the cell surface molecules alpha2beta1 integrin, c-kit, thrombomucin/MEP21, HEMCAM and chL12, reflects functional properties required for cell adhesion, migration and growth factor responsiveness. Importantly, the presence of these antigens was found to correlate with the recolonization of the recipient thymus following intrathymic cell transfers. These intra-embryonic cells were also found to express the Ikaros transcription factor, the molecular function of which is considered to be prerequisite for embryonic lymphoid development.  (+info)

Buy CEACAM18 elisa kit, Canine Carcinoembryonic antigen-related cell adhesion molecule 18 (CEACAM18) ELISA Kit-NP_082512.1 (MBS7211769) product datasheet at MyBioSource, ELISA Kits
Ceacam12 (untagged) - Mouse carcinoembryonic antigen-related cell adhesion molecule 12 (Ceacam12), transcript variant 1, (10ug), 10 µg.
Kakunaga S., Ikeda W., Itoh S., Deguchi-Tawarada M., Ohtsuka T., Mizoguchi A., Takai Y.. Nectins are Ca2+-independent immunoglobulin-like cell-cell adhesion molecules and comprise a family of four members. At the mossy fiber terminals of hippocampus, nectin-1 and nectin-3 localize at the presynaptic and postsynaptic sides of synaptic junctions, respectively, and their trans-interactions play a role in formation of synapses in cooperation with N-cadherin. Nectins are associated with the actin cytoskeleton through afadin, a nectin- and actin-filament-binding protein. Five nectin-like molecules (Necls) which have domain structures similar to those of nectins have been identified and here we characterize Necl-1/TSLL1/SynCAM3, from now on referred to as Necl-1. Tissue distribution analysis showed that Necl-1 was specifically expressed in the neural tissue. Immunofluorescence and immunoelectron microscopy revealed that Necl-1 localized at the contact sites among axons, their terminals, and glia cell ...
Keywords: CEACAM1 Carcinoembryonic antigen-related cell adhesion molecule-1 apoptosis -catenin Fas T-cell Jurkat cell actin cytoskeleton Launch CEACAM1 is normally a transmembrane cell adhesion molecule that is one of the CEA superfamily. A couple of a lot more than ten splicing isoforms of CEACAM1 with the long or a brief cytoplasmic domains and 1-4 Ig-like extracellular domains. CEACAM1 is normally expressed in a variety of tissue including epithelial endothelial and hematopoietic cells. Unlike generally in most tissue where both lengthy and brief isoforms are portrayed as well as the brief isoform may be the main regulatory molecule in epithelial cells [1] the lengthy cytoplasmic isoforms of CEACAM1 (e.g CEACAM1-4L) however not the brief Amiloride hydrochloride dihydrate isoform is Amiloride hydrochloride dihydrate Amiloride hydrochloride dihydrate normally predominantly portrayed in activated individual T-cells being a co-inhibitory molecule [2]. Prior studies established that recruitment of ...
We describe a high-throughput screening system to detect interactions between leucocyte surface proteins, taking into account that these interactions are usually of very low affinity. The method involves producing the extracellular regions of leucocyte proteins with tags so that they can be bound to nanoparticles to provide an avid reagent to screen over an array of 36 similar proteins immobilized using the Proteon XPR36 with detection by surface plasmon resonance. The system was tested using established interactions that could be detected without spurious binding. The ability to detect new interactions was shown by identifying a new interaction between carcinoembryonic antigen-related cell adhesion molecule 1 and carcinoembryonic antigen-related cell adhesion molecule 8.
Build: Wed Jun 21 18:33:50 EDT 2017 (commit: 4a3b2dc). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific ...
A protein encoded by a gene in band 22 of the long arm of human chromosome 21. The gene contains multiple exons which allow multiple mRNAs to be transcribed by alternative splicing (q.v.). The transcripts are differentially expressed in different substructures of the adult brain. The DSCAM is a member of the immunoglobulin domain superfamily (q.v.). These isoforms may be involved in the patterning of neural networks by selective adhesions between axons. See innate immunity. ...
Synaptic cell adhesion molecules (SynCAMs) are crucial for synapse formation and plasticity. However, we have previously demonstrated that SynCAMs are also required during earlier stages of neural circuit formation because SynCAM1 and SynCAM2 (also known as CADM1 and CADM2, respectively) are important for the guidance of post-crossing commissural axons. In contrast to the exclusively homophilic cis-interactions reported by previous studies, our previous in vivo results suggested the existence of heterophilic cis-interactions between SynCAM1 and SynCAM2. Indeed, as we show here, the presence of homophilic and heterophilic cis-interactions modulates the interaction of SynCAMs with trans-binding partners, as observed previously for other immunoglobulin superfamily cell adhesion molecules. These in vitro findings are in agreement with results from in vivo studies, which demonstrate a role for SynCAMs in the formation of sensory neural circuits in the chicken embryo. In the absence of SynCAMs, ...
TY - JOUR. T1 - Surface Marker Epithelial Cell Adhesion Molecule and E-cadherin Facilitate the Identification and Selection of Induced Pluripotent Stem Cells. AU - Chen, Hsin Fu. AU - Chuang, Ching Yu. AU - Lee, Wen Chih. AU - Huang, Hsiang Po. AU - Wu, Han Chung. AU - Ho, Hong Nerng. AU - Chen, Yu Ju. AU - Kuo, Hung Chih. PY - 2011/9/1. Y1 - 2011/9/1. N2 - The derivation of induced pluripotent stem cells (iPSCs) requires not only efficient reprogramming methods, but also reliable markers for identification and purification of iPSCs. Here, we demonstrate that surface markers, epithelial cells adhesion molecule (EpCAM) and epithelial cadherin (E-cadherin) can be used for efficient identification and/or isolation of reprogrammed mouse iPSCs. By viral transduction of Oct4, Sox2, Klf4 and n- or c-Myc into mouse embryonic fibroblasts, we observed that the conventional mouse embryonic stem cell (mESC) markers, alkaline phosphatase (AP) and stage-specific embryonic antigen 1 (SSEA1), were expressed in ...
Recombinant Human Metadherin GST tagged best suppliers; Recombinant Human Metadherin GST tagged best sources; Recombinant Human Metadherin GST tagged best vendors; Recombinant Human Metadherin GST tagged protocol; Recombinant Human Metadherin GST tagged citations; Recombinant Human Metadherin GST tagged publications; Recombinant Human Metadherin GST tagged papers - Labshake
Background: Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), an immunoglobulin (Ig)-related glycoprotein, serves as cellular receptor for a variety of Gram-negative bacterial pathogens associated with the human mucosa. In particular, Neisseria gonorrhoeae, N. meningitidis, Moraxella catarrhalis, and Haemophilus influenzae possess well-characterized CEACAM1-binding adhesins. CEACAM1 is typically involved in cell-cell attachment, epithelial differentiation, neovascularisation and regulation of T-cell proliferation, and is one of the few CEACAM family members with homologues in different mammalian lineages. However, it is unknown whether bacterial adhesins of human pathogens can recognize CEACAM1 orthologues from other mammals.,br /,Results: Sequence comparisons of the amino-terminal Ig-variable-like domain of CEACAM1 reveal that the highest sequence divergence between human, murine, canine and bovine orthologues is found in the β-strands comprising the bacteria-binding ...
Our previous in vitro data suggested that CEACAM1 is involved in angiogenesis. This is supported by a recent proteomic screen for cell membrane components expressed in newly formed tumor vessels and the fact that CEACAM1 expression is upregulated in synergy with other angiogenic factors in cardiac hypoxia (17, 19). To date, however, evidence for a causal implication of CEACAM1 in angiogenesis in vivo was lacking. In the present study, we report on 2 different genetic mouse models in which the angiogenic action of CEACAM1 has been investigated: in CEACAM1endo+ mice, the expression of CEACAM1-L was targeted to endothelia via the Tie2 promoter, and in Ceacam1-/- mice, the Ceacam1 gene was inactivated by targeted disruption (29). In addition, endothelial cells were transfected with cDNAs coding for WT CEACAM1-L and for CEACAM1-L mutants harboring amino acid substitutions in the cytoplasmic domain. In these experimental systems, we provide conclusive evidence that CEACAM1 is involved in angiogenesis ...
PMID: Gut. 2013 Apr 18. Epub 2013 Apr 18. PMID: 23598352. Abstract Title: Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation. Abstract: OBJECTIVE: Western diet is a risk factor for Crohns disease (CD). Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is abnormally expressed in CD patients. This allows adherent-invasive Escherichia coli (AIEC) to colonise the gut mucosa and leads to inflammation. We assessed the effects of a high fat/high sugar (HF/HS) Western diet on gut microbiota composition, barrier integrity and susceptibility to infection in transgenic CEABAC10 mice expressing human CEACAMs. DESIGN: Colonic microbiota composition and susceptibility of CEABAC10 mice to AIEC LF82 bacteria infection were determined in mice fed a conventional or HF/HS diet. Barrier function and inflammatory response were assessed by studying intestinal permeability, tight junction protein and mucin expression and ...
Soluble cell adhesion molecules (sCAMs) are a class of cell adhesion molecule (CAMs - cell surface binding proteins) that may represent important biomarkers for inflammatory processes involving activation or damage to cells such as platelets and the endothelium. They include soluble forms of the cell adhesion molecules ICAM-1, VCAM-1, E-selectin and P-selectin (distinguished as sICAM-1, sVCAM-1, sE-selectin and sP-selectin). The cellular expression of CAMs is difficult to assess clinically, but these soluble forms are present in the circulation and may serve as markers for CAMs. Research has focused on their role in cardiovascular (particularly atherosclerosis), connective tissue and neoplastic diseases, where blood plasma levels may be a marker of the disease severity or prognosis, and they may be useful in evaluating progress of some treatments. Many studies have postulated that increased production of cell adhesion molecules (CAMs) on the vascular endothelium (blood vessel lining) plays a ...
ORF of carcinoembryonic antigen-related cell adhesion molecule 20 (CEACAM20), transcript variant 4L in pENTER vector with CMV promoter and C-terminal FLAG and His tags.
Cell and matrix adhesion of lymphocytes participates in homing, migration and accumulation of these cells in inflamed tissues as well as in the generation of immune and inflammatory responses. In inflamed joints of rheumatoid arthritis (RA) patients, lymphocytes accumulate in the synovial membrane and the synovial fluid. In the present study we have analyzed the expression of integrins and other adhesion molecules in synovial fluid lymphocytes (RA-SFL) and paired peripheral blood lymphocytes (RA-PBL) from 21 RA patients by immunofluorescence flow cytometry. We have also investigated the expression of these adhesion molecules on peripheral blood lymphocytes obtained from 13 sex- and age-matched healthy controls (CO-PBL). RA-SFL, which consisted mostly of T cells, showed higher expression of the integrin subunits beta 1 (CD29), VLA-1 alpha, -3 alpha, -4 alpha, -5 alpha and -6 alpha when compared to RA-PBL. In turn, RA-PBL showed lower expression of these molecules than CO-PBL. The expression of the
Gene target information for Dscam3 - Down syndrome cell adhesion molecule 3 (fruit fly). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell-cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E. Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for various cancers. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies. First discovered in 1979, EpCAM was initially described as a dominant surface antigen on human colon carcinoma. Because of its prevalence on many carcinomas, it has been discovered many different times. EpCAM therefore has many aliases the most notable of which include TACSTD1 (tumor-associated calcium signal transducer 1), CD326 ...
Down Syndrome Cell Adhesion Molecules (dscam and dscaml1) are essential regulators of neural circuit assembly, but their roles in vertebrate neural circuit function are still mostly unexplored. We investigated the functional consequences of dscaml1 deficiency in the larval zebrafish (sexually undifferentiated) oculomotor system, where behavior, circuit function, and neuronal activity can be precisely quantified. Genetic perturbation of dscaml1 resulted in deficits in retinal patterning and light adaptation, consistent with its known roles in mammals. Oculomotor analyses revealed specific deficits related to the dscaml1 mutation, including severe fatigue during gaze stabilization, reduced saccade amplitude and velocity in the light, greater disconjugacy, and impaired fixation. Two-photon calcium imaging of abducens neurons in control and dscaml1 mutant animals confirmed deficits in saccade-command signals (indicative of an impairment in the saccadic premotor pathway), while abducens activation by ...
Definition of Cell adhesion molecule in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is Cell adhesion molecule? Meaning of Cell adhesion molecule as a finance term. What does Cell adhesion molecule mean in finance?
Human being epithelial cell adhesion molecule (HEPCAM) is a tumor-associated antigen frequently expressed in carcinomas, which promotes proliferation after controlled intramembrane proteolysis. which can be connected with mutations from the gene (9). Although Lei (8) reported a particular amount of embryonic lethality, the nice known reasons for these obvious discrepancies in phenotypes stay unknown. Furthermore, molecular systems in charge of the noticed Bay 11-7821 congenital tufting enteropathy phenotypes had been deviating. Guerra (7) suggested a job for adherens junctions having a mislocalization of E-cadherin and -catenin in the developing intestine (7), whereas Lei (8) excluded the participation of E-cadherin and -catenin, which were located properly, and a function was stated by them for mEpcam in the recruitment Bay 11-7821 of claudins to tight junctions. A job for Epcam in the forming of practical adherens junctions via E-cadherin was further referred to during epiboly Rabbit ...
The human pancarcinoma-associated epithelial cell adhesion molecule (EpCAM) (EGP-2, CO17-1A) is a well-known target for carcinoma-directed immunotherapy. Mouse-derived mAbs directed to EpCAM have been used to treat colon carcinoma patients showing well-tolerable toxic side effects but limited antitu …
Recombinant Human Epithelial cell adhesion molecule(EPCAM),partial von Cusabio bei SZABO-SCANDIC erhältlich. Weiteres zu Proteine & Peptide finden Sie hier.
Recombinant Human Epithelial cell adhesion molecule(EPCAM),partial von Cusabio bei SZABO-SCANDIC erhältlich. Weiteres zu Proteine & Peptide finden Sie hier.
cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00059 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00084 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00084 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00008 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA is proteolytically cut by matrix metallopeptidase-3 (M10.005) cleavage... cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA is proteolytically cut by matrix metallopeptidase-1 (M10.001) cleavage... cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA is proteolytically cut by ADAM17 peptidase (M12.217) cleavage. KLDK-SFSM.. ...
In brain, signaling mediated by cell adhesion molecules defines the identity and functional properties of synapses. The specificity of presynaptic and postsynaptic interactions that is presumably mediated by cell adhesion molecules suggests that there exists a logic that could explain neuronal connectivity at the molecular level. Despite its importance, however, the nature of such logic is poorly understood, and even basic parameters, such as the number, identity, and single-cell expression profiles of candidate synaptic cell adhesion molecules, are not known. Here, we devised a comprehensive list of genes involved in cell adhesion, and used single-cell RNA sequencing (RNAseq) to analyze their expression in electrophysiologically defined interneurons and projection neurons. We compared the cell type-specific expression of these genes with that of genes involved in transmembrane ion conductances (i.e., channels), exocytosis, and rho/rac signaling, which regulates the actin cytoskeleton. Using these data,
|jats:p| The junctional adhesion molecules (JAMs) have been recently described as interendothelial junctional molecules and as integrin ligands. Here we show that JAM-B and JAM-C undergo heterophilic interaction in cell-cell contacts and that JAM-C is recruited and stabilized in junctional complexes by JAM-B. In addition, soluble JAM-B dissociates soluble JAM-C homodimers to form JAM-B/JAM-C heterodimers. This suggests that the affinity of JAM-C monomers to form dimers is higher for JAM-B than for JAM-C. Using antibodies against JAM-C, the formation of JAM-B/JAM-C heterodimers can be abolished. This liberates JAM-C from its vascular binding partner JAM-B and makes it available on the apical side of vessels for interaction with its leukocyte counterreceptor α|jats:sub|M|/jats:sub|β|jats:sub|2|/jats:sub| integrin. We demonstrate that the modulation of JAM-C localization in junctional complexes is a new regulatory mechanism for α|jats:sub|M|/jats:sub|β|jats:sub|2|/jats:sub|-dependent adhesion of
TY - JOUR. T1 - Role of cellular adhesion molecules in HIV type 1 infection and their impact on virus neutralization. AU - Hioe, C. E.. AU - Bastiani, L.. AU - Hildreth, James. AU - Zolla-Pazner, S.. PY - 1998. Y1 - 1998. N2 - While CD4 and several chemokine receptors are the principal receptors for human immunodeficiency virus type 1 (HIV-1) viruses, other cell membrane proteins also play a role in HIV-1 infection. A large array of host cell- derived membrane proteins, including adhesion molecules, are incorporated into the envelope of HIV-1 virions, and the profile of host cell proteins acquired by the virus depends on the cells used to propagate the virus. The major leukocyte adhesion molecules, such as leukocyte-function associated antigen-1 (LFA-1), intercellular adhesion molecule-1 (ICAM-1), and CD44, retain their biological functions when expressed on the virion surface, and have been shown to increase virus-cell interaction, enhance virus infectivity, and extend the host cell range of ...
Cell adhesion molecules are cell surface glycoproteins, the function of which is regulated by neurons at different stages of brain development and in response to a variety of external stimuli, for example during learning.. This project will aim to identify and characterise new endogenous regulators of cell adhesion molecules and test artificial regulators of cell adhesion molecules to analyse their pharmacological potential in various disease models.Recombinant protein production, mass spectrometry, protein-protein interaction assays, various protein analysis tools, and cellular models will be used.. ...
Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here. ...
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Antibody Panel to Epithelial Cell Surface Antigen EpCAMAcris Antibodies offers a full range of thoroughly evaluated antibodies for specific detection…
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Cell adhesion molecules play an important role in the development of several chronic fibroproliferative diseases such as glomerulosclerosis, cirrhosis, pulmonary fibrosis, and atherosclerosis.7 The infiltration of monocytes and T lymphocytes, which initiates the atherosclerotic process, is mediated by adhesion receptors. Once they have entered the vascular wall, leucocytes release a variety of cytokines and other bioactive molecules. This results in the proliferation and migration of smooth muscle cells and subsequently promotes the deposition of excess connective tissue.8 These actions are primarily regulated by β1 integrins, although VCAM-1 is also expressed strongly on the surface of activated smooth muscle cells and may help to retain leucocytes within atherosclerotic vessels.9 The αvβ3 integrin has been demonstrated in atherosclerotic plaques10 and may be a therapeutic target that, if blocked, could prevent the formation of new vessels-reducing plaque growth and the migration of smooth ...
Normal and malignant cells release a variety of different vesicles into their extracellular environment. The most prominent vesicles are the microvesicles (MVs, 100-1 000 nm in diameter), which are shed of the plasma membrane, and the exosomes (70-120 nm in diameter), derivates of the endosomal system. MVs have been associated with intercellular communication processes and transport numerous proteins, lipids and RNAs. As essential component of immune-escape mechanisms tumor-derived MVs suppress immune responses. Additionally, tumor-derived MVs have been found to promote metastasis, tumor-stroma interactions and angiogenesis. Since members of the carcinoembryonic antigen related cell adhesion molecule (CEACAM)-family have been associated with similar processes, we studied the distribution and function of CEACAMs in MV fractions of different human epithelial tumor cells and of human and murine endothelial cells. Here we demonstrate that in association to their cell surface phenotype, MVs released ...
TY - JOUR. T1 - Kv2 ion channels determine the expression and localization of the associated AMIGO-1 cell adhesion molecule in adult brain neurons. AU - Bishop, Hannahi. AU - Cobb, Melanie M.. AU - Kirmiz, Michael. AU - Parajuli, Laxmi K.. AU - Mandikian, Danielle. AU - Philp, Ashleigh M.. AU - Melnik, Mikhail. AU - Kuja-Panula, Juha. AU - Rauvala, Heikki. AU - Shigemoto, Ryuichi. AU - Murray, Karl D. AU - Trimmer, James. PY - 2018/1/19. Y1 - 2018/1/19. N2 - Voltage-gated K+ (Kv) channels play important roles in regulating neuronal excitability. Kv channels comprise four principal α subunits, and transmembrane and/or cytoplasmic auxiliary subunits that modify diverse aspects of channel function. AMIGO-1, which mediates homophilic cell adhesion underlying neurite outgrowth and fasciculation during development, has recently been shown to be an auxiliary subunit of adult brain Kv2.1-containing Kv channels. We show that AMIGO-1 is extensively colocalized with both Kv2.1 and its paralog Kv2.2 in ...
The CD56 antigen is a 140 kDa isoform of the Neural Cell Adhesion Molecule (N-CAM). Post-translational modifications to the polypeptide include N- and O- glycosylations, acylation, sulphation and phosphorylation. The different N-CAM isoforms have molecular weights ranging from 135 to 220 kDa. The CD56 antigen is moderately expressed on a subpopulation of peripheral blood large granular lymphocytes and on all cells with NK activity. It is also expressed by subsets of T lymphocytes. CD56 antibodies do not react with granulocytes, monocytes or B cells.
The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. The topology of the molecule, which comprises two immunoglobulin-like domains, is the same as that of the first two domains of CD4 but the relative domain orientation is altered by a fairly flexible linker region. The putative ligand-binding beta-sheet forms a flat surface towards the top of the molecule. Crystal contacts between these surfaces suggest a plausible model for the adhesive interaction.
Read Cell Adhesion Molecules Cellular Recognition Mechanisms by with Rakuten Kobo. The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto,...
The four GPI-anchored cell adhesion molecules that exemplify the IgLON family are most highly expressed in the nervous system and associate to form up to six different heterodimeric Diglons that can modify cell adhesion and inhibit axon migration. Recently, two members, OPCML and LSAMP, were ident …
Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell-cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes ...
Recombinant Human Cell Adhesion Molecule 3 is produced by our Mammalian expression system and the target gene encoding Asn25-His330 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #C435
The cell-cell adhesion molecule 1 (C-CAM1) plays an important role as a tumor suppressor for prostate cancer. Decreased expression of C-CAM1 was detected in prostate, breast, and colon carcinoma. Reexpression of C-CAM1 in prostate and breast cancer cell lines was able to suppress tumorigenicity in vivo. These observations suggest that C-CAM1 may be used as a marker for cancer detection or diagnosis. To generate monoclonal antibodies specific to C-CAM1, we have overexpressed full-length human C-CAM1 in Sf9 cells using a baculovirus expression system. The protein was purified 104-fold using nickel affinity chromatography. About 0.4 mg purified C-CAM1 was obtained from 200 mg of infected cells. When the purified protein was digested with peptidyl-N-glycosidase, the apparent mobility of the protein on SDS-PAGE changed from 90 to 58 kDa, which is close to the molecular weight predicted from the cloned cDNA sequence. This observation suggests that C-CAM1 was glycosylated on asparagine residues when expressed
Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface-binding site for therapeutic antibodies. Recent findings can better explain the relevance of EpCAMs high-level expression on human cancers and cancer propagating cells, and its negative prognostic potential for survival of patients with certain cancers. EpCAM has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.
The members of the IgLON superfamily of cell adhesion molecules facilitate fundamental cellular communication during brain development, maintain functional brain circuitry, and are associated with several neuropsychiatric disorders. Usage of alternative promoter-specific 1a and 1b mRNA isoforms in Lsamp, Opcml, Ntm and the single promoter of Negr1 in the mouse and human brain has been previously described. To determine the precise spatiotemporal expression dynamics of Lsamp, Opcml, Ntm isoforms and Negr1, in the developing brain, we generated isoform-specific RNA probes and carried out in situ hybridization in the developing (embryonic, E10.5, 13.5, 17; post natal, P0) and adult mouse brains. We show that promoter-specific expression of IgLONs is established early during pallial development (at E10.5), where it remains throughout its differentiation through adulthood. In the diencephalon, midbrain and hindbrain, strong expression patterns are initiated a few days later and begin fading after birth,
The mechanism by which low affinity adhesion molecules function to produce stable cell-cell adhesion is unknown. In solution, the interaction of human CD2 with its ligand CD58 is of low affinity (500 mM-1) and the interaction of rat CD2 with its ligand CD48 is of still lower affinity (40 mM-1). At the molecular level, however, the two systems are likely to be topologically identical. Fluorescently labeled glycosylphosphatidylinositol-anchored CD48 and CD58 were prepared and incorporated into supported phospholipid bilayers, in which the ligands were capable of free lateral diffusion. Quantitative fluorescence imaging was used to study the binding of cell surface human and rat CD2 molecules to the fluorescent ligands in contact areas between Jurkat cells and the bilayers. These studies provide two major conclusions. First, CD2/ligand interactions cooperate to align membranes with nanometer precision leading to a physiologically effective two-dimensional affinity. This process does not require the intact
Background: To analyze the expression of Metadherin (MTDH), Carcinoembryonic Antigen related Cell adhesion Molecule 1 (CEACAM1) and Hepatitis B virus ..
Cell adhesion molecules (CAM) have four major superfamilies or groups: immunoglobulin superfamily (IgCAM) of cell adhesion molecules, cadherin, integrin and lectin-like domain protein C-type superfamily (CTLD).
[54 Pages Report] Check for Discount on Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (Carcinoembryonic Antigen or CEA or Meconium Antigen 100 or CD66e or CEACAM5) - Pipeline Review, H1 2016 report by Global Markets Direct. Global Markets Directs, Carcinoembryonic Antigen-Related Cell Adhesion Molecule...
TY - JOUR. T1 - Structural model of the catalytic domain of an enzyme with cell adhesion activity: human vascular adhesion protein-1 (HVAP-1) D4 domain is an amine oxidase. AU - Salminen, Tiina. AU - Smith, DJ. AU - Jalkanen, S. AU - Johnson, Mark S. PY - 1998. Y1 - 1998. N2 - Human vascular adhesion protein-1 (HVAP-1) is a multifunctional protein having at least two different cellular roles, functioning both as a lymphocyte-endothelial cell adhesion protein and as an enzyme with monoamine oxidase activity. HVAP-1 is a 180 kDa homodimeric glycoprotein consisting of a membrane-spanning domain and three predicted extracellular copper-containing amine oxidase domains. In HVAP-1 the extracellular domains are composed of a large domain DJ, containing the active site and forming the interface of the dimer, while the smaller D2 and D3 domains surround the D4 dimer near the entrance to the active site. The structural model of the catalytic D4 domain of HVAP-1 reveals that all components necessary for ...
|span style=font-family:Times,serif;font-size:9pt;>The CC1 monoclonal antibody specifically recognizes carcinoembryonic antigen-related cell adhesion molecule 1a (CEACAM1a or CEACAM1[a]), an allotypic form of CEACAM1 which is also known as CD66a, Murine hepatitis virus receptor (MHV-R), or Biliary glycoprotein 1 (BGP-1). Four known isoforms of mouse CD66a arise from alternative splicing of RNA transcripts encoded by |/span>|span style=font-style:italic;font-family:Times,serif;font-size:9pt;>Ceacam1|/span>|span style=font-family:Times,serif;font-size:9pt;>, a member of the carcinoembryonic antigen (CEA) family and Ig gene superfamily. These isoforms are type I transmembrane proteins that include a heavily glycosylated extracellular region with an N-terminal IgV-like domain and up to three IgC2-like domains followed by a transmembrane region and a cytoplasmic tail of relatively short (10 amino acids) or long (73 amino acids) length. The cytoplasmic tails enable interactions with other intracellular
Human vascular adhesion protein-1 (HVAP-1) is a multifunctional protein having at least two different cellular roles, functioning both as a lymphocyte-endothelial cell adhesion protein and as an enzyme with monoamine oxidase activity. HVAP-1 is a 180 kDa homodimeric glycoprotein consisting of a membrane-spanning domain and three predicted extracellular copper-containing amine oxidase domains. In HVAP-1 the extracellular domains are composed of a large domain DJ, containing the active site and forming the interface of the dimer, while the smaller D2 and D3 domains surround the D4 dimer near the entrance to the active site. The structural model of the catalytic D4 domain of HVAP-1 reveals that all components necessary for enzymatic monoamine oxidase activity are indeed present within the HVAP-1 and pinpoints residues that may be key to substrate entry through a channel to the active site and residues likely to be involved in substrate specificity as well as structural features critical to dimer ...
Background T cell exhaustion has recently been proposed as an alternative mechanism to prevent memory development and tissue damage arising during ischemia-reperfusion injury (IRI) in murine orthotopic liver transplantation (OLT), with carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) identified as a key ligand for TIM-3-mediated negative immune regulation in the liver. In our cohort of human OLT patients, IRI+ recipients had a 12-fold higher ratio of TIM-1+:TIM-3+ CD4+ T cells at 3 months post-transplant than IRI-. Aim We sought to investigate donor and recipient contributions to CEACAM1 expression in human OLT-IRI. Methods We compared the cellular expression of CEACAM1 biopsies obtained from the donor organ pre- and post-reperfusion with the recipient's portal blood. Additionally, we evaluated CEACAM1 expression of 3rd party healthy donor monocytes co-cultured for 4 days with recipient portal blood obtained both pre- and post-reperfusion through the donor organ. Results ...
Junctional adhesion molecule-C (JAM-C) is an adhesion molecule involved in transendothelial migration of leukocytes. In this study, we examined JAM-C expression in the synovium and investigated the role of this molecule in two experimental mouse models of arthritis. JAM-C expression was investigated by reverse transcriptase-polymerase chain reaction and immunohistochemistry. The effects of a monoclonal anti-JAM-C antibody were assessed in antigen-induced arthritis (AIA) and K/BxN serum transfer-induced arthritis. JAM-C was expressed by synovial fibroblasts in the lining layer and associated with vessels in the sublining layer in human and mouse arthritic synovial tissue. In human tissue, JAM-C expression was increased in rheumatoid arthritis (RA) as compared to osteoarthritis synovial samples (12.7 ± 1.3 arbitrary units in RA versus 3.3 ± 1.1 in OA; p | 0.05). Treatment of mice with a monoclonal anti-JAM-C antibody decreased the severity of AIA. Neutrophil infiltration into inflamed joints was
Dr. Blumberg is Professor of Medicine, Harvard Medical School, Chief of Gastroenterology, Brigham and Womens Hospital, co-Director of the Harvard Digestive Diseases Center and past-Director of the Brigham Research Institute. He has directed a National Institutes of Health funded laboratory since 1989 which has a particular emphasis on the immunologic functions of the intestinal epithelium; a field that his laboratory has pioneered through the study of non classical MHC class I molecules and more recently the unfolded protein response and Paneth cell function and is a leading authority on carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) and the neonatal crystallizable fragment receptor (FcRn) function. Dr. Blumberg has been the recipient of the an NIH Method to Extend Research in Time (M.E.R.I.T) Award (2005), the William Beaumont Prize (2009), the CCFA Scientific Achievement Award in Inflammatory Bowel Disease Basic Research (2012), a Lifetime Scientific Achievement Award from the ...
Inflammation is related to many diseases, such as atherosclerosis, rheumatoid arthritis and metabolic diseases. Vascular adhesion protein-1 (VAP-1) is an endothelial adhesion molecule involved in leukocyte trafficking cascades from blood circulation to the sites of inflammation. In normal condition, VAP-1 is stored in intracellular granules. During inflammation it is rapidly translocated from the intracellular storage granules to the endothelial cell surface. Siglec-9 is a leukocyte ligand of VAP-1 and Siglec-9 motif containing peptide can be used as a positron emission tomography (PET) tracer for in vivo imaging of inflammation-related diseases ...
TY - JOUR. T1 - ENDOTHELIAL CELL ADHESION MOLECULES IN PSORIASIS. AU - Lee, May‐Lian ‐L. AU - To, Shing Shun Tony. AU - Nicholson, Ellen. AU - Schrieber, Leslie. PY - 1994/1/1. Y1 - 1994/1/1. N2 - Skin biopsies from patients with psoriasis and normal controls were examined for the expression of cell adhesion molecules including intercellular adhesion molecule‐1 (ICAM‐1) endothelial leukocyte adhesion molecule‐1 (ELAM‐1), HECA‐452 and 4D10, using an immunoperoxidase techique. This study demonstrates that psoriatic skin exhibits a wide variety of markers of endothelial cell activation which are either induced or increased expression (ICAM‐1, ELAM‐1 & 4D10). Moreover, ICAM‐1 & HECA‐452 are also on leukocytes. These antigens may facilitate the adhesion of inflammatory cells to endothelium and antigen‐presenting cells in psoriatic skin. Thus, they may play a role in faciliating the infiltration of leukocytes into psoriatic skin.. AB - Skin biopsies from patients with psoriasis ...
In arthropods like Drosophila, Down syndrome cell adhesion molecules (Dscam1) exhibit enormous molecular diversity. A single Dscam1 gene encodes a large superfamily of neuronal cell recognition proteins that control neuronal outgrowth and anatomy. A comparable function is exhibited by the vertebrates DSCAMs of which only few isoforms exist. However, it is largely unknown, if and how this function of Dscams affects neuronal function and the control of behavior by the nervous system. In this thesis, I employed an arsenal of genetic techniques to perturb the expression level of Dscam1 isoforms in directionally selective Lobula Plate Tangential Cells (LPTCs). LPTCs of the Vertical (VS) and the Horizontal System (HS) were chosen as a model system because of their well-documented anatomy, role in information processing and behavior. Though, only little is known about the developmental mechanisms and molecular factors controlling the morphogenesis and wiring of these cells. The central aim of my study ...
Cell Biol Int. 2021 Mar 24. doi: 10.1002/cbin.11598. Online ahead of print.. ABSTRACT. Overexpression of breast cancer resistance protein (BCRP) plays a crucial role in the acquired multidrug resistance (MDR) in breast cancer. The elucidation of molecular events that confer BCRP-mediated MDR is of major therapeutic importance in breast cancer. Epithelial cell adhesion molecule (EpCAM) has been implicated in tumor progression and drug resistance in various types of cancers, including breast cancer. However, the role of EpCAM in BCRP-mediated MDR in breast cancer remains unknown. In the present study, we revealed that EpCAM expression was upregulated in BCRP-overexpressing breast cancer MCF-7/MX cells, and EpCAM knockdown using siRNA reduced BCRP expression and increased the sensitivity of MCF-7/MX cells to mitoxantrone (MX). Epithelial-mesenchymal transition (EMT) promoted BCRP-mediated MDR in breast cancer cells, and EpCAM knockdown partially suppressed EMT progression in MCF-7/MX cells. In ...
Purpose Among cell adhesion molecules, serum degrees of intercellular adhesion molecule-1 and E-selectin are regarded as correlated with the metastatic potential of gastric cancer. in gastric cancers tissue and cultured gastric cancers cells were elevated, however, E-selectin in gastric cancers tissue and cells werent elevated. Among 157 gastric malignancy patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and experienced larger tumor FCRL5 size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion. The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-12 months survival than the negative group (54.9 vs. 85.9%, respectively). Conclusions Intercellular adhesion molecule-1 is usually overexpressed in gastric malignancy tissues and cultured gastric malignancy cells, whereas E-selectin is not overexpressed. Increased expression of intercellular adhesion molecule-1 in gastric ...
CEACAM6 (carcinoembryonic antigen related cell adhesion molecule 6), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
I have examined the distribution of neural cell adhesion molecule (N-CAM) in cultured C2 myogenic cells and other cell lines to determine if N-CAM accumulates at sites of cell-cell contact. C2 cells growing in log phase display large clusters of neural cell adhesion molecule where they contact each other. These clusters are remarkably stable, do not form at cell-substrate contacts, and appear not to be enriched in a number of other cytoskeletal, membrane, or extracellular proteins. Thus, N-CAM clusters form preferentially in response to cell-cell contact and are specifically enriched in N-CAM. As C2 cultures mature and differentiate, clusters persist at contacts between aligning myoblasts and between myotubes, consistent with a role in myogenesis. N-CAM is also enriched at cell-cell contacts in cultures of PC12, NRK, and CHO cells. These cells have significant amounts of N-CAM as detected on immunoblots. Clusters are not seen in L929 cells, which do not have detectable amounts of N-CAM. ...
HIV pseudotypes bearing native hepatitis C virus (HCV) glycoproteins (pressure H and Con1) are infectious for the human hepatoma cell traces Huh-7 and PLC/PR5. Infectivity will depend on coexpression of each E1 and E2 glycoproteins, is pH-dependent, and could be neutralized by mAbs mapping to amino acids 412-447 inside E2. Cell-surface expression of 1 or all the candidate receptor molecules (CD81, low-density lipoprotein receptor, scavenger receptor class B sort 1, and dendritic cell-specific intercellular adhesion molecule three grabbing nonintegrin) didnt confer permissivity to HIV-HCV pseudotype an infection. Nonetheless, HIV-HCV pseudotype infectivity was inhibited by a recombinant soluble type of CD81 and a mAb particular for CD81, suggesting that CD81 could…. ...
TY - JOUR. T1 - Monoclonal antibodies to human lymphocyte homing receptors define a novel class of adhesion molecules on diverse cell types. AU - Picker, L. J.. AU - Nakache, M.. AU - Butcher, E. C.. PY - 1989. Y1 - 1989. N2 - A 90-kD lymphocyte surface glycoprotein, defined by monoclonal antibodies of the Hermes series, is involved in lymphocyte recognition of high endothelial venules (HEV). Lymphocyte gp90(Hermes) binds in a saturable, reversible fashion to the mucosal vascular addressin (MAd), a tissue-specific endothelial cell adhesion molecule for lymphocytes. We and others have recently shown that the Hermes antigen is identical to or includes CD44 (In[Lu]-related p80), human Pgp-1, and extracellular matrix receptor III-molecules reportedly expressed on diverse cell types. Here, we examine the relationship between lymphoid and non-lymphoid Hermes antigens using serologic, biochemical, and, most importantly, functional assays. Consistent with studies using mAbs to CD44 or Pgp-1, mAbs ...
Levels of the neural cell adhesion molecule N-CAM in muscle are regulated in parallel with the susceptibility of muscle to innervation: N-CAM is abundant on the surface of early embryonic myotubes, declines in level as development proceeds, reappears when adult muscles are denervated or paralyzed, and is lost after reinnervation (Covault, J., and J. R. Sanes, 1985, Proc. Natl. Acad. Sci. USA, 82:4544-4548). Here we used immunocytochemical methods to compare this pattern of expression with those of several other molecules known to be involved in cellular adhesion. Laminin, fibronectin, and a basal lamina-associated heparan sulfate proteoglycan accumulate on embryonic myotubes after synapse formation, and their levels change little after denervation. L1, J1, nerve growth factor-inducible large external protein, uvomorulin, and a carbohydrate epitope (L2/HNK-1) shared by several adhesion molecules are undetectable on the surface of embryonic, perinatal, adult, or denervated adult muscle fibers. ...
TY - JOUR. T1 - Sex differences in the expression of cell adhesion molecules on microvesicles derived from cultured human brain microvascular endothelial cells treated with inflammatory and thrombotic stimuli. AU - Hunter, Larry W.. AU - Jayachandran, Muthuvel. AU - Miller, Virginia M.. N1 - Funding Information: This work was supported by NIH grant NIH P50 AG44170 and the Mayo Foundation. Publisher Copyright: © 2019 The Author(s).. PY - 2019/5/22. Y1 - 2019/5/22. N2 - Background: There are sex differences in risk for stroke and small vessel ischemic disease in the brain. Microvesicles (MV) derived from activated cells vary by cell of origin and the stimulus initiating their release. MV released from cells activated by inflammatory and thrombotic factors have the potential to disrupt endothelial cells of the brain microvasculature. Therefore, experiments were designed to identify sex differences in the phenotype of MV released from cultured human brain microvascular endothelial cells (HBMEC) in ...
Purchase Recombinant Human Platelet endothelial cell adhesion molecule(PECAM1),partial. It is produced in Yeast. High purity. Good price.
TY - JOUR. T1 - Innate signaling by the C-type lectin DC-SIGN dictates immune responses. AU - den Dunnen, J.. AU - Gringhuis, S.I.. AU - Geijtenbeek, T.B.H.. PY - 2009. Y1 - 2009. N2 - Effective immune responses depend on the recognition of pathogens by dendritic cells (DCs) through pattern recognition receptors (PRRs). These receptors induce specific signaling pathways that lead to the induction of immune responses against the pathogens. It is becoming evident that C-type lectins are also important PRRs. In particular, the C-type lectin DC-SIGN has emerged as a key player in the induction of immune responses against numerous pathogens by modulating TLR-induced activation. Recent reports have begun to elucidate the molecular mechanisms underlying these immune responses. Upon pathogen binding, DC-SIGN induces an intracellular signaling pathway with a central role for the serine/threonine kinase Raf-1. For several pathogens that interact with DC-SIGN, including Mycobacterium tuberculosis and ...
A new study published in Biological Psychiatry suggests that autism is associated with reductions in the level of cellular adhesion molecules in the blood, where they play a role in immune function.. Cell adhesion molecules are the glue that binds cells together in the body. Deficits in adhesion molecules would be expected to compromise processes at the interfaces between cells, influencing tissue integrity and cell-to-cell signaling. In the brain, deficits in adhesion molecules could compromise brain development and communication between nerve cells.. Over the years, deficits in neural cell adhesion molecules have been implicated in schizophrenia and other psychiatric disorders. One adhesion molecule, neurexin, is strongly implicated in the heritable risk for autism.. Cell adhesion molecules also play a crucial role in regulating immune cell access to the central nervous system. Prior research provided evidence of immune system dysfunction in individuals diagnosed with autism spectrum disorder ...
BACKGROUND The cell adhesion between vascular endothelial cells and leukocytes is an important process for the immuno-inflammatory changes. To clarify the basic features of inflammatory bowel disease (IBD), studies of in situ localization of the cell adhesion molecules are required. EXPERIMENTAL DESIGN We analyzed the immunohistochemical localization of the adhesion molecules (ICAM-1, LFA-1, Mac-1, VCAM-1, VLA-4, P- and E-selectins) in IBD, stressing phenotypical changes of endothelial cells. RESULTS In the normal mucosa, ICAM-1 was expressed in capillaries and venules, LFA-1 in some lymphocytes and VLA-4 in most lymphocytes. VCAM-1 was expressed sporadically in venules and constantly in follicular dendritic cells (FDC) in lymphoid follicles. Both E- and P-selectins were sporadically expressed in venules. In actively inflamed mucosa in IBD, a marked increase of all these antigens was observed; ICAM-1+ inflammatory infiltrates (lymphocytes, plasma cells, and macrophages) and ICAM-1+ venules increased
Cadherin cell adhesion molecules play crucial tasks in vertebrate development including the development of the retina. of embryonic zebrafish resulted in similar eye problems. Our results suggest that protocadherin-17 plays an important part in the normal formation of the zebrafish retina. ((MO (MOs sequences showed no significant similarities to any sequences (using BLAST) other than zebrafish (GenBank accession quantity: XM 684743). MOs were microinjected into one- to four-cell stage embryos (1.5-3 ng/embryo) in Daneau buffer (58 mM NaCl, 0.7 mM KCl, 0.4 mM MgSO4, 0.6 mM Ca(NO3)2, 5.0 mM HEPES pH 7.6). The zebrafish coding region was amplified with primers comprising EcoRI (5) and XbaI (3) restriction sites and cloned 1st into pCR2.1-TOPO vector (Existence Systems, Carlsbad, CA), followed by cloning into pCS2+MT vector (Dr. Pamela Raymond, the University of Michigan). The pCS2+MT/pcdh17 was verified by restriction digestion and sequencing (Macrogen, Rockville, MD). Capped mRNA was synthesized ...
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-660 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting detachment signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cells active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the
Albany, New York, August 9, 2017: Market Research Hub (MRH) has recently highlighted the pipeline landscape of Intercellular Adhesion Molecule 1 in a new report added to its repository, with a title of Intercellular Adhesion Molecule 1 (Major Group Rhinovirus Receptor or CD54 or ICAM1) - Pipeline Review, H2 2017. The main purpose of this study is to provide an assessment of the various pipeline targeted therapeutics, together with analysis by indications, stage of development, route of administration (RoA), mechanism of action (MoA) and molecule type. Through this analysis, the readers will gain strategically significant competitor information, analysis and key insights to frame effective R&D strategies.. Request Free Sample Report: Initially, this pipeline guide covers intercellular Adhesion Molecule 1 (ICAM-1) overview along with precise information on its therapeutic development. This section provides data on targeted ...
TY - JOUR. T1 - Extracellular matrix molecules and cell adhesion molecules induce neurites through different mechanisms. AU - Bixby, J. L.. AU - Jhabvala, P.. N1 - Copyright: Copyright 2007 Elsevier B.V., All rights reserved.. PY - 1990. Y1 - 1990. N2 - It has recently become clear that both extracellular matrix (ECM) glycoproteins and various cell adhesion molecules (CAMs) can promote neurite outgrowth from primary neurons, though little is known of the intracellular mechanisms through which these signals are transduced. We have previously obtained evidence that protein kinase C function is an important part of the neuronal response to laminin (Bixby, J. L. 1989. Neuron. 3:287-297). Because such CAMs as L1 (Lagenauer, C., and V. Lemmon. 1987. Proc. Natl. Acad. Sci. USA. 84:7753-7757) and N-cadherin (Bixby, J. L. and R. Zhang. 1990. J. Cell Biol. 110:1253-1260) can be purified and used as substrates to promote neurite growth, we have now tested whether the response to CAMs is similarly dependent ...
TY - JOUR. T1 - The shed ectodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation. AU - Conacci-Sorrell, Maralice. AU - Kaplan, Anna. AU - Raveh, Shani. AU - Gavert, Nancy. AU - Sakurai, Takeshi. AU - Ben-Zeev, Avri. PY - 2005/12/15. Y1 - 2005/12/15. N2 - Nr-CAM, a cell-cell adhesion molecule of the immunoglobulin-like cell adhesion molecule family, known for its function in neuronal outgrowth and guidance, was recently identified as a target gene of β-catenin signaling in human melanoma and colon carcinoma cells and tissue. Retrovirally mediated transduction of Nr-CAM into fibroblasts induces cell motility and tumorigenesis. We investigated the mechanisms by which Nr-CAM can confer properties related to tumor cell behavior and found that Nr-CAM expression in NIH3T3 cells protects cells from apoptosis in the absence of serum by constitutively activating the extracellular signal-regulated kinase and AKT signaling pathways. We detected a ...
To evaluate the expression and test the clinical significance of the epithelial cellular adhesion molecule (Ep-CAM) in esophageal squamous cell carcinoma (SCC) to check the suitability of esophageal SCC patients for Ep-CAM directed targeted therapies. The Ep-CAM expression was immunohistochemically investigated in 70 primary esophageal SCCs using the monoclonal antibody Ber-EP4. For the interpretation of the staining results, we used a standardized scoring system ranging from 0 to 3+. The survival analysis was calculated from 53 patients without distant metastasis, with R0 resection and at least 2 months of clinical follow-up. Ep-CAM neo-expression was observed in 79% of the tumors with three expression levels, 1+ (26%), 2+ (11%) and 3+ (41%). Heterogeneous expression was observed at all expression levels. Interestingly, tumors with 3+ Ep-CAM expression conferred a significantly decreased median relapse-free survival period (log rank, p = 0.0001) and median overall survival (log rank, p = 0.0003).
TY - JOUR. T1 - The role of endothelial cell adhesion molecules in the development of atherosclerosis. AU - Berman, Joan W.. AU - Calderon, Tina M.. PY - 1992/1/1. Y1 - 1992/1/1. N2 - The vascular endothelium serves as a dynamic interface between circulating blood elements and the interstitial tissues. As such, it communicates to cells within the vessel wall as well as to the surrounding tissue, sensing its environment and responding accordingly. The vasculature must maintain a delicate balance when initiating a functional response by producing both proinflammatory and antiinflammatory mediators, vasoconstrictors and vasodilators, growth stimulators and inhibitors, and prothrombogenic and antithrombogenic factors. Any response to injurious agents could lead to pathology. Confounding this complex interplay is the fact that the very response to injury that may have developed to undo the damage may itself be even more deleterious. One response to injury by the endothelium is the new or increased ...
ABSTRACT: INTRODUCTION: The adhesion protein junctional adhesion molecule-A (JAM-A) regulates epithelial cell morphology and migration, and its over-expression has recently been linked with increased risk of metastasis in breast cancer patients. As cell migration is an early requirement for tumor metastasis, we sought to identify the JAM-A signalling events regulating migration in breast cancer cells. METHODS: MCF7 breast cancer cells (which express high endogenous levels of JAM-A) and primary cultures from breast cancer patients were used for this study. JAM-A was knocked down in MCF7 cells using siRNA to determine the consequences for cell adhesion, cell migration and the protein expression of various integrin subunits. As we had previously demonstrated a link between the expression of JAM-A and β1-integrin, we examined activation of the β1-integrin regulator Rap1 GTPase in response to JAM-A knockdown or functional antagonism. To test whether JAM-A, Rap1 and β1-integrin lie in a linear pathway, we
Cells attach to proteoglycans and glycoproteins on the surface of other cells as well as in the extracellular matrix (ECM) substratum via adhesion molecules to define tissue shape, structure, and function. Making and breaking cellular contacts with other cells and the ECM play critical roles in normal processes such as cell growth, division, differentiation, and migration. Cardiovascular and central nervous system disorders and pathophysiological processes such as fibrosis and inflammation require ECM remodeling. Remodeling involves expression of different cell adhesion molecules, altering cellular processes such as migration and polarity. Key ECM proteins include fibronectin, laminin, and collagens as well as metalloproteinases that remodel the ECM. Important cell adhesion genes include integrins, selectins, celladhesion molecule family members (ICAM, ECAM, NCAM, PECAM, and VCAM), and the catenins which link cell adhesion molecules and the cytoskeleton. Analysis of these essential genes may ...
Phenotype data for mouse gene Epcam. Discover Epcams significant phenotypes, expression, images, histopathology and more. Data for gene Epcam is all freely available for download.
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TY - JOUR. T1 - Chemokine production and adhesion molecule expression by neural cells exposed to IL-1, TNFα and interferon. AU - Chuluyan, H. Eduardo. AU - Lang, Bianca J.. AU - Yoshimura, Teizo. AU - Kenney, John S.. AU - Issekutz, Andrew C.. PY - 1998/10/16. Y1 - 1998/10/16. N2 - We investigated the effect of TNFα, IL-1α and IFNγ on two neuroblastoma (NB) cell lines (SK-N-SH and SK-N-MC). These lines responded differentially to IL-1α, TNFα and IFNγ for MCP-1 and IL-8 production and expression of the ICAM-1 and VCAM-1 adhesion molecules. None of the cytokines induced MCP-1 or 1L-8 on SK-N-MC cells. Both chemokines were produced in response to IL-1α by SK-N-SH cells, while TNFα induced mainly MCP-1 production. Addition of IFNγ decreased IL-8, but not MCP-1 production. These responses correlated with monocyte and neutrophil chemotactic activity in NB culture supernatants. This activity was neutralized by antibodies to IL-8 and MCP-1. The expression of ICAM-1 on SK-N-MC was up-regulated ...
Looking for endothelial leukocyte? Find out information about endothelial leukocyte. : see blood blood, fluid pumped by the heart that circulates throughout the body via the arteries, veins, and capillaries . An adult male of average size... Explanation of endothelial leukocyte
TY - JOUR. T1 - Recognition of the neural chemoattractant netrin-1 by integrins α6β4 and α3β1 regulates epithelial cell adhesion and migration. AU - Yebra, Mayra. AU - Montgomery, Anthony M P. AU - Diaferia, Giuseppe R.. AU - Kaido, Thomas. AU - Silletti, Steve. AU - Perez, Brandon. AU - Just, Margaret L.. AU - Hildbrand, Simone. AU - Hurford, Rosemary. AU - Florkiewicz, Elin. AU - Tessier-Lavigne, Marc. AU - Cirulli, Vincenzo. PY - 2003/11. Y1 - 2003/11. N2 - Netrins, axon guidance cues in the CNS, have also been detected in epithelial tissues. In this study, using the embryonic pancreas as a model system, we show that Netrin-1 is expressed in a discrete population of epithelial cells, localizes to basal membranes, and specifically associates with elements of the extracellular matrix. We demonstrate that α6β4 integrin mediates pancreatic epithelial cell adhesion to Netrin-1, whereas recruitment of α6β4 and α3β1 regulate the migration of CK19+/PDX1+ putative pancreatic progenitors on ...
The diffusion characteristics of BoNT have been well studied in humans7-10 and animals11,12 using a variety of techniques, including compound muscle action potentials (CMAPs) and motor-evoked potentials,7 histological determination of glycogen-depleted muscles,13 acetylcholine esterase staining,14 muscle fiber diameter variability,15 and quantitative electromyography (EMG) measures of muscle activity.16. Evidence for diffusion comes from both animal and human studies. In a study using muscle biopsy to identify spread, Borodic et al.15 reported a diffusion gradient of BoNT/A over a distance of 30-45 mm from the point of injection into latissimus dorsi muscle of rabbits.14 The extent of denervation gradient or diffusion was dose dependent. Another study used neural cell adhesion molecule (N-CAM) staining to assess the diffusion of activity of equipotent doses of three BoNT/A formulations from the point of injection along the mouse hind limb. The results showed a similar time course of paralysis, ...
Chronic inflammation and reduced blood levels of omega-3 fatty acids (n − 3) are known characteristics of sickle cell disease (SCD).The anti-inflammatory properties of n − 3 fatty acids are well recognized.. Omega-3 treated (n = 24), hydroxyurea (HU) treated (n = 18), and n − 3 untreated (n = 21) homozygous SCD patients (HbSS) and healthy (HbAA) controls (n = 25) matched for age (5-16 years), gender and socioeconomic status were studied. According to age (5-10) or (11-16) years, two or three capsules containing 277.8 mg docosahexaenoic (DHA) and 39.0 mg eicosapentaenoic (EPA) or high oleic acid placebo (41%) were assigned to n − 3 treated and n − 3 untreated groups, respectively. Hydroxyurea treated group was on dosage more than 20 mg/kg/day. The effect of supplementation on systemic and blood cell markers of inflammation was investigated.. The n − 3 treated group had higher levels of DHA and EPA (p , 0.001) and lower white blood cell count and monocyte integrin (p , 0.05) compared ...
Cancer cell metastasis is one of the most critical steps in tumor development and is responsible for more than 80 of cancer related deaths. Among the molecules involved in promoting cancer metastasis, the role of the cell adhesion molecules, CD44 and CD146 are well known in promoting cancer cell motility and metastasis. Despite this knowledge, the molecular mechanism through which CD44 promotes tumor development and cell metastasis is still nascent. CD146 (MUC 18) was, first identified in highly metastatic melanomas. The absence of CD146 in normal melanocytes and its high expression in melanomas suggests its tumor promoting actions. Despite the association between CD146 expression and development of melanoma, its expression patterns and role in normal and metastatic breast tissues still remains controversial. This study aims to elucidate some of these discrepancies by presenting CD146 as a downstream target for CD44, in a way such that CD146 expression is related to CD44 and regulates the tumor ...
View mouse Madcam1 Chr10:79664559-79668537 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
We investigated the expression status of periostin in breast cancer stem cells and its clinical implications in order to lay a foundation for managing breast cancer. CD44+/CD24−/line- tumor cells (CSC) from clinical specimens were sorted using flow cytometry. Periostin expression status was detected in CSC cells and 1,086 breast cancer specimens by Western blot and immunohistochemistry staining, with the CSC ratio determined by immunofluorescence double staining. The relationship between the periostin protein and clinico-pathological parameters and prognosis was subsequently determined. As a result, CSC cells are more likely to generate new tumors in mice and cell microspheres that are deficient in NOD/SCID compared to the control group. Periostin protein was expressed higher in CSC cells compared to the control cells and was found to be related to CSC chemotherapy resistance. Moreover, periostin expression was found to be related to the CSC ratio in 1,086 breast cancer specimens (P = 0.001). In total
RecName: Full=E-selectin;AltName: Full=CD62 antigen-like family member E;AltName: Full=Endothelial leukocyte adhesion molecule 1 {ECO:0000303,PubMed:1375914}; Short=ELAM-1;AltName: Full=Leukocyte-endothelial cell adhesion molecule 2; Short ...
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Cell adhesion molecule. .mw-parser-output .nobold{font-weight:normal}. IgSF CAM:. *OFC7 ... Neurons, Schwann cells, and fibroblasts work together to create a functional nerve. Schwann cells and neurons exchange ... Cell membrane protein disorders (other than Cell surface receptor, enzymes, and cytoskeleton) ... X-linked CMT and Schwann cells[edit]. CMT can also be produced by X-linked mutations, and is named X-linked CMT (CMTX). In CMTX ...
Cell adhesion molecule. .mw-parser-output .nobold{font-weight:normal}. IgSF CAM:. *OFC7 ... Cell membrane protein disorders (other than Cell surface receptor, enzymes, and cytoskeleton) ... Among the methods thought to hold promise for treatment include gene transfer therapy,[13] which works by inserting in cells of ...
Cell adhesion molecule. .mw-parser-output .nobold{font-weight:normal}. IgSF CAM:. *OFC7 ... Cell membrane protein disorders (other than Cell surface receptor, enzymes, and cytoskeleton) ... Boklage CE (2010). How new humans are made cells and embryos, twins and chimeras, left and right, mind/selfsoul, sex, and ... Maternal alcohol use has also been linked to cleft lip and palate due to the effects on the cranial neural crest cells. The ...
Cell adhesion molecule. .mw-parser-output .nobold{font-weight:normal}. IgSF CAM:. *OFC7 ... Cell membrane protein disorders (other than Cell surface receptor, enzymes, and cytoskeleton) ...
Jansen S, Ekhlasi-Hundrieser M, Töpfer-Petersen E (2001). "Sperm adhesion molecules: structure and function". Cells Tissues ... cell adhesion. • binding of sperm to zona pellucida. • sperm-egg recognition. • carbohydrate metabolic process. ... SPAM1, HEL-S-96n, HYA1, HYAL1, HYAL3, HYAL5, PH-20, PH20, SPAG15, sperm adhesion molecule 1. ... "Entrez Gene: SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)".. ...
High levels of the adhesion molecule CD44 on leukemic cells are essential to generate leukemia.[24] Furthermore, because ... The CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. In humans, the ... CD44 is a multistructural and multifunctional cell surface molecule involved in cell proliferation, cell differentiation, cell ... wound healing, spreading of cells. • regulation of lamellipodium morphogenesis. • cell-cell adhesion. • positive regulation of ...
Cells in each layer bound together cell-adhesion molecules, but no basement membranes except Homoscleromorpha.[16]. inter-cell ... Nerve cells. Sensory cells appear between or sometimes on top of the muscle cells,[9] and communicate via synapses (gaps across ... Number of cells in middle "jelly" layer Many. Few. (Not applicable) Cells in outer layers can move inwards and change functions ... Main cell layers[edit]. Cnidaria are diploblastic animals; in other words, they have two main cell layers, while more complex ...
CD44 proteins belong to a family of cell surface adhesion molecules that are involved in both cell-cell and cell-matrix ... CD44 Cell adhesion molecules. Mol Path, 52: 189-196. Ioannidis, P., and T. Trangas., 2006. CRD-BP/IMP1: An RNA Binding Protein ... RNA-binding IMPs promote cell adhesion and invadopodia formation. EMBO 25: 1456-1468. Goodison, S., et al. 1999. ... Upon binding to its transcripts, CRD-BP plays a role in translation by stabilizing and localizing the transcripts in the cell. ...
Johansson MW (1999). "Cell adhesion molecules in invertebrate immunity". Dev. Comp. Immunol. 23 (4-5): 303-15. doi:10.1016/ ... NDR1 is also believed to be involved in cell wall adhesion to the plasma membrane and fluid retention of the cell. In addition ... Hynes, Richard (1992). "Integrins: Versatility, Modulation, and Signaling in Cell Adhesion". Cell. 69 (1): 11-25. doi:10.1016/ ... The extracellular matrix of plant cells, fungi, and some protist is referred to as the cell wall. The plant cell wall is ...
Brümmendorf T, Rathjen FG (1995). "Cell adhesion molecules 1: immunoglobulin superfamily". Protein Profile. 2 (9): 963-1108. ... Williams AF, Barclay AN (1988). "The immunoglobulin superfamily-domains for cell surface recognition". Annu. Rev. Immunol. 6: ...
... there is a deactivation of the homophilic adhesion molecule known as the neural cell adhesion molecule (NCAM) or its homologs. ... Axons express patterns of cell-surface adhesion molecules that allow them to match with specific layer targets. An important ... Washbourne, P. (2004-10-20). "Cell Adhesion Molecules in Synapse Formation". Journal of Neuroscience. 24 (42): 9244-9249. doi: ... while both cells start expressing adhesion molecules on their respective membranes to form tight junctions, called "puncta ...
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. • response to hypoxia. • response to nutrient. • ... cell-cell adhesion. • cytokine-mediated signaling pathway. • heterotypic cell-cell adhesion. • innervation. • cardiac neuron ... Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 ( ... "Entrez Gene: VCAM1 vascular cell adhesion molecule 1".. *^ a b Barreiro O, Yanez-Mo M, Serrador JM, Montoya MC, Vicente- ...
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a ... CEACAM5, CD66e, CEA, carcinoembryonic antigen related cell adhesion molecule 5. External IDs. HomoloGene: 128801 GeneCards: ... homotypic cell-cell adhesion. • negative regulation of apoptotic process. • negative regulation of anoikis. • negative ... Cell. Biol. 10 (6): 2738-48. PMC 360634 . PMID 2342461.. *. Kamarck ME, Elting JJ, Hart JT, et al. (1987). "Carcinoembryonic ...
The neural cell adhesion molecule N-CAM simultaneously combines with another N-CAM and a fibroblast growth factor receptor to ... Berezin, Vladimir (2009-12-17). Structure and Function of the Neural Cell Adhesion Molecule NCAM. Springer Science & Business ... A neurite or neuronal process refers to any projection from the cell body of a neuron. This projection can be either an axon or ... The term is frequently used when speaking of immature or developing neurons, especially of cells in culture, because it can be ...
The two LAMP molecules act as ligands for the cell-adhesion molecules. ... are activation-dependent cell surface glycoproteins in human peripheral blood mononuclear cells which mediate cell adhesion to ... It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome ... LAMP2, along with LAMP1, interact with E-selectin and galectins to mediate the adhesion of some cancer cells to the ECM. ...
Frijns CJ, Kappelle LJ (Aug 2002). "Inflammatory cell adhesion molecules in ischemic cerebrovascular disease". Stroke: A ... With the roles of ICAM-1 in cell-cell adhesion, extravasation, and infection more fully understood, a potential role for ICAM-1 ... This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system ... ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is ...
Bennett CF, Condon TC, Grimm S, Chan H, Chiang MY (1994). "Inhibition of endothelial cell-leukocyte adhesion molecule ... "Adhesion molecules in inflammatory bowel disease". Gut. 36 (5): 724-30. doi:10.1136/gut.36.5.724. PMC 1382677. PMID 7541009.. ... Ulcerative colitis is an autoimmune disease characterized by T-cells infiltrating the colon.[35] No direct causes for UC are ... Chronic blood loss may lead to iron deficiency as a cause for anemia, particularly microcytic anemia (small red blood cells), ...
Cashman NR, Covault J, Wollman RL, Sanes JR (May 1987). "Neural cell adhesion molecule in normal, denervated, and myopathic ... Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV Merkel-cell carcinoma. RNA virus. HCV ... The virus then hijacks the host cell's own machinery, and begins to replicate. Poliovirus divides within gastrointestinal cells ... if the affected nerve cells are completely destroyed, paralysis will be permanent; cells that are not destroyed, but lose ...
Interaction between CD4 and class II MHC molecules mediates cell adhesion.. „Nature". 330 (6145). s. 256-9. DOI: 10.1038/ ... Cell". 55 (2), s. 301-8, Oct 1988. PMID: 3262426. *↑ DA. Vignali, KM. Vignali. Profound enhancement of T cell activation ... Altered proximal T cell receptor (TCR) signaling in human CD4+CD25+ regulatory T cells.. „J Leukoc Biol". 80 (1), s. 145-51, ... Separation of functional subsets of human T cells by a monoclonal antibody.. „Proc Natl Acad Sci U S A". 76 (8), s. 4061-5, Aug ...
The structure of PTPmu suggests that it can regulate cell adhesion and migration using its extracellular cell adhesion molecule ... "Regulation of cell adhesion by protein-tyrosine phosphatases: II. Cell-cell adhesion". J Biol Chem. 281 (24): 16189-92. doi: ... Craig SE, Brady-Kalnay SM (2011). "Cancer cells cut homophilic cell adhesion molecules and run". Cancer Res. 71 (2): 303-9. doi ... Burridge K, Sastry SK, Sallee JL (2006). "Regulation of cell adhesion by protein-tyrosine phosphatases. I. Cell-matrix adhesion ...
The fusion requires the regulation of cell adhesion molecules. The neural plate switches from E-cadherin expression to N- ... Neural crest cells will migrate through the embryo and will give rise to several cell populations, including pigment cells and ... The variation in cell shapes is partially determined by the location of the nucleus within the cell, causing bulging in areas ... this is not one set of cells but rather is a constantly changing group of cells that are migrating over the dorsal lip of the ...
... cell-adhesion molecules in synaptic plasticity". Trends in Cell Biology. 10 (11): 473-82. doi:10.1016/S0962-8924(00)01838-9. ... Rikitake Y, Mandai K, Takai Y (August 2012). "The role of nectins in different types of cell-cell adhesion". Journal of Cell ... "Roles and modes of action of nectins in cell-cell adhesion". Seminars in Cell & Developmental Biology. 15 (6): 643-56. doi: ... For example, cell adhesion molecules (CAMs) play a large role in synaptic maintenance and stabilization. Gerald Edelman ...
"Entrez Gene: Sidekick cell adhesion molecule 1". Retrieved 2018-05-31. "OMIM: SIDEKICK CELL ADHESION MOLECULE 1; SDK1". ... Sidekick cell adhesion molecule 1 is a protein that in humans is encoded by the SDK1 gene. The protein encoded by this gene is ... "Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis". J. Biol. Chem. ... heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]. ...
... is a cell adhesion molecule. CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and ... and CD29 define a surface biomarker code for neural lineage differentiation of stem cells". Stem Cells. 27 (12): 2928-40. doi: ... Carl JW, Liu JQ, Joshi PS, El-Omrani HY, Yin L, Zheng X, Whitacre CC, Liu Y, Bai XF (July 2008). "Autoreactive T cells escape ... Vesuna F, Lisok A, Kimble B, Raman V (December 2009). "Twist modulates breast cancer stem cells by transcriptional regulation ...
SIDEKICK CELL ADHESION MOLECULE 2; SDK2". Yamagata M, Weiner JA, Sanes JR (Sep 2002). "Sidekicks: synaptic adhesion molecules ... heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene ... that promote lamina-specific connectivity in the retina". Cell. 110 (5): 649-60. doi:10.1016/S0092-8674(02)00910-8. PMID ...
ALGAL-CAM: algal cell adhesion molecule. ISG: inversion-specific glycoprotein. FLA: fasciclin like AGP. ENODL: earlt nodulation ... Huber, O.; Sumper, M. (1994-09-15). "Algal-CAMs: isoforms of a cell adhesion molecule in embryos of the alga Volvox with ... A Multigene Family of Putative Cell Adhesion Molecules". Plant Physiology. 133 (4): 1911-1925. doi:10.1104/pp.103.031237. ISSN ... "The Arabidopsis SOS5 Locus Encodes a Putative Cell Surface Adhesion Protein and Is Required for Normal Cell Expansion". The ...
Reid RA, Bronson DD, Young KM, Hemperly JJ (1994). «Identification and characterization of the human cell adhesion molecule ... four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily.». J. Neurobiol. 28 (1): ... 1998). «Regulated expression of the cell adhesion glycoprotein F3 in adult hypothalamic magnocellular neurons.». J. Neurosci. ... 2001). «Mobilization of the cell adhesion glycoprotein F3/contactin to axonal surfaces is activity dependent.». Eur. J. ...
Protocadherins function as cell adhesion molecules, essential for synaptic specificity. The mechanism for Protocadherin gene ... 2020). "Molecular Basis of Chemotactile Sensation in Octopus". 183 (3). Cell. pp. 594-604. doi:10.1016/j.cell.2020.09.008. " ... Cells in the digestive gland directly release pigmented excretory chemicals into the lumen of the gut, which are then bound ... The fertilised ovum initially divides to produce a disc of germinal cells at one pole, with the yolk remaining at the opposite ...
Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene. Cell adhesion molecules (CAMs) are ... Grumet M (1997). "Nr-CAM: a cell adhesion molecule with ligand and receptor functions". Cell Tissue Res. 290 (2): 423-8. doi: ... NRCAM neuronal cell adhesion molecule". Marui T, Funatogawa I, Koishi S, et al. (2008). "Association of the neuronal cell ... This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III ...
As cell adhesion molecules, they often bind "homophilically" to themselves; for example L1 on one cell binding to L1 on an ... The L1 family is a family of cell adhesion molecules that includes four different L1-like proteins. They are members of the ... Wei CH, Ryu SE (July 2012). "Homophilic interaction of the L1 family of cell adhesion molecules". Experimental & Molecular ... "The L1 Family of neural adhesion molecules". Swarthmore College. Karp G (2008). Cell and molecular Biology: Concepts and ...
... s are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two ... F9 embryonal carcinoma cells are similar to the P19 cells shown in Figure 1 and normally have cell-to-cell adhesion mediated by ... providing the cell with a means of stable cell adhesion. However, decreases in this adhesion ability of the cell has been ... A tumor cell line with defective δ-catenin, low levels of E-cadherin and poor cell-to-cell adhesion could be restored to normal ...
... epidermal hair cells (trichomes), cells in the stomatal complex; guard cells and subsidiary cells. The epidermal cells are the ... Waxy micro- and nanostructures on the surface reduce wetting by rain and adhesion of contamination (See Lotus effect). ... The sugars are then stored as starch, further processed by chemical synthesis into more complex organic molecules such as ... Cells that bring water and minerals from the roots into the leaf.. Phloem. Cells that usually move sap, with dissolved sucrose( ...
... which reduces the availability of specific integrins responsible for cell adhesion to the intercellular structure and causes ... immune defense molecules indicative of Ebola infection were found in three bat species; at various periods of study, between ... dendritic cells and other cells including liver cells, fibroblasts, and adrenal gland cells.[93] Viral replication triggers ... doi:10.1016/j.cell.2014.10.006. PMC 4243531. PMID 25417101.. *^ a b c d e f g h Kühl A, Pöhlmann S (September 2012). "How Ebola ...
... has a general regulatory effect on the cell cycle.. *It increases MHC II and adhesion molecules LFA-1 and LFA-3 ( ... cells in destroying these B cells. When an NK cell latched onto the cap, it had an 80% success rate at killing the cell. In ... The antibody binds to the cell surface protein CD20. CD20 is widely expressed on B cells, from early pre-B cells to later in ... It induces apoptosis of CD20+ cells.. The combined effect results in the elimination of B cells (including the cancerous ones) ...
"Substance P enhances cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) expression on cultured rheumatoid fibroblast- ... Substance P has been known to stimulate cell growth in normal and cancer cell line cultures,[37] and it was shown that ... on cells (including cancer cells) bestowing upon them mobility.[40] and metastasis.[41] It has been suggested that cancer ... stem cells, white blood cells) in many tissues and organs. SP amplifies or excites most cellular processes.[15][16] ...
The skin consists of a thin outer epidermis with mucous cells and sensory cells, and a connective tissue dermis consisting ... The infundibulum provides adhesion while the acetabulum remains free, and muscle contractions allow for attachment and ... which involves changes to the nucleic acid sequence of the primary transcript of RNA molecules) than any other organisms. ... Other colour-changing cells are reflective iridophores and white leucophores.[93] This colour-changing ability is also used to ...
of Cell and Dev. Biol. 13: 425-456. *↑ Colman R. D. ja Filbin T. M. (2006). Cell adhesion molecules, lk 111-121. George J. ... Walsh, F. S., Doherty, P. (1997). Neural cell adhesion molecules of the immunoglobulin superfamily: Role in Axon Growth and ... opioid-binding cell adhesion molecule) ja Kilon/Neurotractin (vastavalt roti ja kana ortoloogid)[4]. Lisaks kolmele Ig domeeni ... of positive and negative regulatory elementsgoverning cell-type-specific expression of the neural cell adhesion molecule gene. ...
"Cell. 157 (6): 1380-1392. doi:10.1016/j.cell.2014.05.009. PMC 4144415 . PMID 24906154.. ... One element, cobalt, is available for use by animals only after having been processed into complex molecules (e.g., vitamin B12 ... "Reduced Adhesion of Oral Bacteria on Hydroxyapatite by Fluoride Treatment". Langmuir. doi:10.1021/la4008558. Retrieved 2017-06 ... Boron is an essential plant nutrient, required primarily for maintaining the integrity of cell walls.[45][46][47] Boron has ...
Some types of cell adhesion proteins or cell adhesion molecules (CAMs) such as integrins, cadherins, NCAMs, or selectins ... and proteins responsible for cell adhesion. Classification of transporters can be found in Transporter Classification Database. ... The C terminal end of the protein is in the cytosol while the N terminal region is in the outside of the cell. A membrane that ... Steven R. Goodman (2008). Medical cell biology. Academic Press. pp. 37-. ISBN 978-0-12-370458-0. . Retrieved 24 November 2010. ...
Yang J, Ye Y, Carroll A, Yang W, Lee H (2001). "Structural biology of the cell adhesion protein CD2: alternatively folded ... "The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line ... Wilkins A, Yang W, Yang J (2003). "Structural biology of the cell adhesion protein CD2: from molecular recognition to protein ... 2002). "Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation.". ...
cell maturation. • Wnt signaling pathway. • embryonic camera-type eye development. • multicellular organism development. • cell ... cellular response to molecule of bacterial origin. • positive regulation of interferon-gamma production. • embryonic axis ... T cell differentiation in thymus. • chorionic trophoblast cell differentiation. • positive regulation of protein targeting to ... negative regulation of cell proliferation. • signal transduction. • Wnt signaling pathway, calcium modulating pathway. • Wnt ...
These molecules within the cell, which operate as substrates, provide a suitable environment for the cell to carry out ... Adhesion - Holding together cells and tissues.. *Cell movement - Chemotaxis, contraction, cilia and flagella. ... Cell signaling - Regulation of cell behavior by signals from outside.. *Division - By which cells reproduce either by mitosis ( ... Prokaryotic cells are much smaller than eukaryotic cells, making prokaryotic cells the smallest form of life.[11] Cytologists ...
... to improve cell adhesion or study the properties of biofilms. An example of Langmuir-Blodgett troughs' utility in ... The LB trough's general objective is to study the properties of monolayers of amphiphilic molecules. An amphiphilic molecule is ... and then compress or expand these molecules on the surface, thereby modifying the molecular density, or area per molecule. This ... A Langmuir-Blodgett trough (LB trough) is a laboratory apparatus that is used to compress monolayers of molecules on the ...
Lactose, a disaccharide molecule found in milk and dairy products, cannot be directly absorbed through the wall of the small ... "Transcriptional heterogeneity in the lactase gene within cell-type is linked to the epigenome". Scientific Reports. 7 (1): ... "Transcriptional heterogeneity in the lactase gene within cell-type is linked to the epigenome". Scientific Reports. 7: 41843. ...
T cells displaying co-receptor CD4 are known as CD4+ T cells. These cells have T-cell receptors and CD4 molecules that, in ... Leukocyte adhesion deficiency. *Familial cold urticaria. *Leukemia (chronic myelogenous (CML)) and other myeloproliferative ... B cells: releases antibodies and assists activation of T cells. *T cells: *CD4+ Th (T helper) cells: activate and regulate T ... Natural killer cells: virus-infected and tumor cells.. Deeply staining, eccentric. NK-cells and cytotoxic (CD8+) T-cells. Years ...
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. • cell recognition. • homophilic cell adhesion via ... cell adhesion molecule binding. • protein binding involved in heterotypic cell-cell adhesion. • glycosylated region protein ... heterotypic cell-cell adhesion. • positive regulation of transforming growth factor beta production. • cell-cell adhesion. • ... cell-cell adherens junction. • мембрана. • клеточная мембрана. • поверхность клетки. • аксон. • neuron projection. • neuronal ...
Annexin A5 forms a shield around negatively charged phospholipid molecules, thus reducing their availability for coagulation. ... adhesion *Bernard-Soulier syndrome. *aggregation *Glanzmann's thrombasthenia. *platelet storage pool deficiency *Hermansky- ... deranged production of hormones and signalling molecules by trophoblasts, as well as activation of coagulation and complement ...
... with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell ... BDNF mediates more pathways involved in these enrichment-induced processes than any other molecule and is strongly regulated by ... cell-cell signaling. • positive regulation of brain-derived neurotrophic factor receptor signaling pathway. • collateral ... regulation of protein localization to cell surface. • regulation of receptor activity. • activation of phospholipase C activity ...
... adhesion molecule expression, and leukocyte recruitment into the inflamed intestine". Journal of Leukocyte Biology. 76 (3): 537 ... "Peroxisomes as a source of reactive oxygen species and nitric oxide signal molecules in plant cells". Trends in Plant Science. ... "The expression of different superoxide dismutase forms is cell-type dependent in olive (Olea europaea L.) leaves". Plant & Cell ... The cytosols of virtually all eukaryotic cells contain an SOD enzyme with copper and zinc (Cu-Zn-SOD). For example, Cu-Zn-SOD ...
Research at the cell level can deliver proteins, ions, or specific small molecules into the intercellular cleft as a means of ... July 1998). "Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular ... which is important in cell-cell recognition and cell signaling, is more developed. The organization of the endocardial ... An intercellular cleft is a channel between two cells through which molecules may travel and gap junctions and tight junctions ...
homophilic cell adhesion via plasma membrane adhesion molecules. • synapse assembly. • calcium-dependent cell-cell adhesion via ... "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779-90. PMID ...
... adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO).[123] Additionally, the UPS also plays ... "Cell. 137 (1): 133-45. doi:10.1016/j.cell.2009.01.041. PMC 2668214. PMID 19345192.. ... Cell cycle controlEdit. Cell cycle progression is controlled by ordered action of cyclin-dependent kinases (CDKs), activated by ... Apoptosis is mediated through disrupting the regulated degradation of pro-growth cell cycle proteins.[88] However, some cell ...
It is a potent chemoattractant for neutrophils, and promotes the expression of adhesion molecules on endothelial cells, helping ... positive regulation of heterotypic cell-cell adhesion. • negative regulation of mitotic cell cycle. • endothelial cell ... but it is produced also by a broad variety of cell types including lymphoid cells, mast cells, endothelial cells, cardiac ... positive regulation of leukocyte adhesion to arterial endothelial cell. • positive regulation of leukocyte adhesion to vascular ...
"Cell. 142 (5): 687-698. doi:10.1016/j.cell.2010.07.041. PMC 2956412. PMID 20813258.. ... fat cell differentiation. • signal transduction. • G-protein coupled receptor signaling pathway. • detection of chemical ... Additionally, GPR120 has been implicated to be involved in the ability to taste fats.[9] It is expressed in taste bud cells ( ... specifically cell type II, which contain other G-protein coupled taste receptors), and its absence leads to reduced preference ...
These include the various cells of the gastric glands, taste cells, pancreatic duct cells, enterocytes and microfold cells. ... Bile is released into the small intestine in order to help in the digestion of fats by breaking down larger molecules into ... Another product is iron, which is used in the formation of new blood cells in the bone marrow.[5] Medicine treats the spleen ... The parietal cells in the fundus of the stomach, produce a glycoprotein called intrinsic factor which is essential for the ...
The T-cell receptor, or TCR, is a molecule found on the surface of T cells, or T lymphocytes,[1] that is responsible for ... The TCR is a member of the immunoglobulin superfamily, a large group of proteins involved in binding, recognition, and adhesion ... T cells expressing this receptor are referred to as α:β (or αβ) T cells, though a minority of T cells express an alternate ... The antigen sensitivity is higher in antigen-experienced T cells than in naive T cells. Naive T cells pass through the process ...
The secretion of IL-6 by bone marrow stromal cells (BMSC) and the secretion of the adhesion molecules VCAM-1, ICAM-1 and LFA, ... They decrease the levels of adhesion molecules paramount to osteoclast activation, decrease the formation of the cells that ... thereby reducing the secretion of adhesion molecules leading to fewer MM cells adhering to BMSC. Osteoclasts become highly ... is induced in the presence of TNF-α and the adhesion of MM cells to BMSC. In vitro proliferation of MM cell lines and ...
... also plays a role in cell-to-cell adhesion (a mechanism employed by cells of the immune system) via sugar-binding ... or other organic molecules. This enzymatic process produces one of the fundamental biopolymers found in cells (along with DNA, ... prevalent form of glycosylation and is important for the folding of many eukaryotic glycoproteins and for cell-cell and cell- ... The donor molecule is often an activated nucleotide sugar.. *The process is non-templated (unlike DNA transcription or protein ...
"Thrombolysis with tissue plasminogen activator alters adhesion molecule expression in the ischemic rat brain". Department of ... "Stroke and T-cells". Laboratory of Neurosciences, National Institute on Aging Intramural Research Program; Arumugam TV, Granger ... sickle cell anemia. Trombositemia dan sejenisnya. *Hypercoaguable states-puerperium. oral contraceptive use. 'sticky platelet ... "Group of Neuroplasticity and Regeneration, Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology ...
Endothelial cells in heart sections were prominent. Brain sections were negative for intracellular adhesion molecule-1. ... Within the red blood cells some merozoites develop into trophozoites, which in turn mature into schizonts that rupture to ... The spleen and liver had abundant pigment containing macrophages and parasitized red blood cells. The kidney had evidence of ... Histological examination showed sequestration of pigmented parasitized red blood cells in the vessels of the cerebrum, ...
... is local tumor cell invasion. HNSCC invasion is a necessary component of metastasis where tumor... ... The primary reason for treatment failure in patients with head and neck squamous cell carcinoma (HNSCC) ... These cell-cell adhesions are responsible for forming stratifying cell layers, but also influence the differentiated state of ... Kang HG, Jenabi JM et al (2007) E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through ...
Definition of cell adhesion molecule. Provided by Stedmans medical dictionary and Includes medical terms and ... cell adhesion molecule. Definition: proteins that hold cells together, uvomorulin, and hold them to their substrates, laminin. ...
Endothelial cell adhesion molecules in inflammation and postischemic reperfusion injury.. Beekhuizen H1, van de Gevel JS. ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
... the expression of specific adhesion molecules within human cancer tissues are highlighted. The expression signatures from ... Defining the minimal adhesion receptors preserved on cancer cells during tumor progression will define the metastatic adhesion ... CELL ADHESION-MEDIATED RADIATION RESISTANCE: THE ROLE OF INTEGRINS AND INTEGRIN PROXIMAL PROTEIN ... In this volume, the expression of specific adhesion molecules within human cancer tissues are highlighted. The expression ...
Also disclosed is a method for detecting binding between cell adhesion membrane proteins and cells having a potential to be ... The DNA molecules encoding these proteins have use in gene therapy regimes. ... The present invention relates to proteins associated with human bone marrow cell membranes for adhering hematopoietic cells to ... human bone marrow cell membranes. These proteins are soluble in lithium dodecyl sulfate but insoluble in 2% nonaethylene glycol ...
BCAM stands for B-Cell Adhesion Molecule. BCAM is defined as B-Cell Adhesion Molecule somewhat frequently. ... Cell-Adhesion-Molecule-(BCAM).html,BCAM,/a,. Citations. *MLA style: "BCAM." Acronym Finder. 2021. 16 Jun. ... 2021 *Chicago style: Acronym Finder. S.v. "BCAM." Retrieved ... n.d.) Acronym Finder. (2021). Retrieved June 16 2021 from ...
cell-cell adhesion via plasma-membrane adhesion molecules ISS Inferred from Sequence or Structural Similarity. more info ... homophilic cell adhesion via plasma membrane adhesion molecules ISS Inferred from Sequence or Structural Similarity. more info ... homophilic cell adhesion via plasma membrane adhesion molecules NAS Non-traceable Author Statement. more info ... Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded ...
... Trends Cell Biol. 2000 Nov;10(11):473-82. doi: 10.1016/ ... Cell-adhesion molecules are important constituents of synapses, with well-recognized roles in building and maintaining synaptic ... However, growing evidence indicates that cell-adhesion molecules also play important and diverse roles in regulating synaptic ... 1 Program in Cell Adhesion, The Mount Sinai School of Medicine of New York University, 1425 Madison Ave., New York, NY, 10029, ...
Intracellular adhesion molecule-1 (ICAM-1), Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Cell Adhesion Molecule-1 ... Intracellular adhesion molecule-1 (ICAM-1), Vascular Cell Adhesion Molecule-1 Inhibitor ... 32 Abstracts with Vascular Cell Adhesion Molecule-1 Inhibitor Research. Filter by Study Type. Animal Study. ... Pharmacological Actions : Neuroprotective Agents, Vascular Cell Adhesion Molecule-1 Inhibitor Additional Keywords : Blood Brain ...
Compare cell adhesion molecule ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews ... Human Platelet/Endothelial Cell Adhesion Molecule (PECAM1) ELISA Kit *Detection Target: Platelet/Endothelial Cell Adhesion ... Detection Target: carcinoembryonic antigen-related cell adhesion molecule 5. *Detection Range: Detect Range: 5 ng/ml-120 ng/ml ... Human Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (non-specific cross reacting antigen), CEACAM6 ELISA Kit ...
Goat polyclonal Cell adhesion molecule 4 antibody validated for WB, ELISA, IHC and tested in Human. Immunogen corresponding to ... Lane 1 : Anti-Cell adhesion molecule 4 antibody (ab109767) at 0.1 µg/ml. Lane 2 : Anti-Cell adhesion molecule 4 antibody ( ... Anti-Cell adhesion molecule 4 antibody. See all Cell adhesion molecule 4 primary antibodies. ... Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- ...
Immunoglobulin molecules such as the intercellular adhesion molecules (ICAM-1, 2, and 3), vascular cell adhesion molecule 1 ( ... Cell adhesion molecules and cardiovascular pathology. Although adhesion molecules are vital for the normal development and ... 1993) Vascular cell adhesion molecule-1 and smooth muscle cell activation during atherogenesis. J Clin Invest 92:538-539. ... Several cell adhesion molecules are found in soluble form within the serum, shed principally from endothelial cells and, in the ...
Rabbit polyclonal Cell adhesion molecule 2 antibody. Validated in WB and tested in Human. Cited in 5 publication(s). Immunogen ... Anti-Cell adhesion molecule 2 antibody. See all Cell adhesion molecule 2 primary antibodies. ... All lanes : Anti-Cell adhesion molecule 2 antibody (ab64873) at 1/500 dilution. Lane 1 : Extracts from HepG2 cells. Lane 2 : ... Galuska SP et al. Synaptic cell adhesion molecule SynCAM 1 is a target for polysialylation in postnatal mouse brain. Proc Natl ...
Saccharide-Mediated Cell Adhesion Molecules*Saccharide-Mediated Cell Adhesion Molecules. *Saccharide Mediated Cell Adhesion ... "Cell Adhesion Molecules" by people in Harvard Catalyst Profiles by year, and whether "Cell Adhesion Molecules" was a major or ... "Cell Adhesion Molecules" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Cell Adhesion Molecules*Cell Adhesion Molecules. *Adhesion Molecules, Cell. *Molecules, Cell Adhesion ...
Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.. Ramer R1, Bublitz K, ... This study investigates the role of intercellular adhesion molecule-1 (ICAM-1) within this action. In the lung cancer cell ... Cannabinoids inhibit cancer cell invasion via increasing tissue inhibitor of matrix metalloproteinases-1 (TIMP-1). ... ICAM-1-dependent anti-invasive cannabinoid effects were confirmed in primary tumor cells from a lung cancer patient. In athymic ...
Biliary glycoprotein (BGP) is the human homologue of a cell adhesion molecule (CAM) of the rat designated Cell-CAM. The BGP ... Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas. M Neumaier, S ... Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas ... Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas ...
This study investigates the role of intercellular adhesion molecule-1 (ICAM-1) within this action. In the lung cancer cell ... Cannabinoids inhibit cancer cell invasion via increasing tissue inhibitor of matrix metalloproteinases-1 (TIMP-1). ... Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1 FASEB J. 2012 Apr;26(4): ... This study investigates the role of intercellular adhesion molecule-1 (ICAM-1) within this action. In the lung cancer cell ...
Soluble cell adhesion molecules (sCAMs) are a class of cell adhesion molecule (CAMs - cell surface binding proteins) that may ... Soluble forms of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin (termed sICAM-1, sVCAM-1 ... May 1998). "Soluble cell adhesion molecules in hypertriglyceridemia and potential significance on monocyte adhesion". ... They include soluble isoforms of the cell adhesion molecules ICAM-1, VCAM-1, E-selectin and P-selectin (distinguished as sICAM- ...
1 on the T cell and its ligand, intercellular adhesion molecule (ICAM)-1, on the APC] concentrate at the cell-cell interface ... Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. ... Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells ... Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells ...
Chemorepulsion and cell adhesion molecules in patterning initial trajectories of sensory axons * * MASUDA Tomoyuki ... Cell adhesion molecules regulate guidance of dorsal root ganglion axons in the marginal zone and their invasion into the mantle ... Binding between the neural cell adhesion molecules axonin-1 and Nr-CAM/Bravo is involved in neuron-glia interaction SUTER DM ... Neural crest cell-cell adhesion controlled by sequential and subpopulation-specific expression of novel cadherins NAKAGAWA S. ...
1988) Neuron-glia cell adhesion molecule interacts with neurons and astroglia via different binding mechanisms. J Cell Biol 106 ... Growth cones express various cell adhesion molecules (CAMs) that recognize localized guidance cues present on neighboring cells ... 1996) Neuroglian-mediated cell adhesion induces assembly of the membrane skeleton at cell contact sites. J Cell Biol 133:647- ... The Ig superfamily cell adhesion molecule, apCAM, mediates growth cone steering by substrate-cytoskeletal coupling. J Cell Biol ...
Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion ... Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity). ... heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: HGNCInferred from sequence or structural ... Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent ...
Click on grid cells to view annotations.. *Blue cells = expressed in wild-type.. Gray triangles = other expression annotations ...
May inhibit cell growth through suppression of cell proliferation. ... Involved in regulating cell motility and cell-matrix interactions. ... "Structural and functional analyses of a novel Ig-like cell adhesion molecule, hepaCAM, in the human breast carcinoma MCF7 cells ... "Structural and functional analyses of a novel Ig-like cell adhesion molecule, hepaCAM, in the human breast carcinoma MCF7 cells ...
Two distinct calcium-sensitive cell-cell adhesion molecules were identified in human epithelial tissues and carcinomas using ... Cadherin Cell-Adhesion Molecules in Human Epithelial Tissues and Carcinomas. Yutaka Shimoyama, Setsuo Hirohashi, Shinji Hirano ... Cadherin Cell-Adhesion Molecules in Human Epithelial Tissues and Carcinomas. Yutaka Shimoyama, Setsuo Hirohashi, Shinji Hirano ... Cadherin Cell-Adhesion Molecules in Human Epithelial Tissues and Carcinomas. Yutaka Shimoyama, Setsuo Hirohashi, Shinji Hirano ...
1997) Spleen-derived stromal cells. Adhesion molecules expression and lymphocyte adhesion to reticular cells. Eur. J. Cell Biol ... 1992) Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of α4β1 (VLA-4) and α4β7 on the human B cell ... 1996) Adhesion receptors on bone marrow stromal cellsin vivo expression of vascular cell adhesion molecule-1 by reticular cells ... 1997) Vascular cell adhesion molecule-1 is expressed by cortical thymic epithelial cells and mediates thymocyte adhesion. ...
The cadherins: cell-cell adhesion molecules controlling animal morphogenesis Message Subject (Your Name) has sent you a message ... providing direct evidence for a key role of cadherins in cell-cell adhesion. It has been suggested that cadherins bind cells by ... Cadherins are a family of glycoproteins involved in the Ca2+-dependent cell-cell adhesion mechanism which is detected in most ... that each cadherin subclass has binding specificity and this molecular family is involved in selective cell-cell adhesion. In ...
... neuronal cell adhesion molecule), Authors: Justyna Janik, Barbara Czarnocka. Published in: Atlas Genet Cytogenet Oncol Haematol ... NRCAM, neuronal cell adhesion molecule, Bos taurus. - Nrcam, neuron-glia-CAM-related cell adhesion molecule, Mus musculus. - ... Nrcam, neuron-glia-CAM-related cell adhesion molecule, Rattus norvegicus. - NRCAM, neuronal cell adhesion molecule, Gallus ... NRCAM, neuronal cell adhesion molecule, Pan troglodytes. - LOC475881, similar to Neuronal cell adhesion m..., Canis lupus ...
In cell adhesion, CD56 contributes to cell-cell adhesion or cell-matrix adhesion during embryonic development. ... Expression in normal cells. The neural cell adhesion molecule NCAM1 appears on early embryonic cells and is important in the ... Τ cells and activated CD8+ T cells, as well as on dendritic cells.[1] NCAM has been implicated as having a role in cell-cell ... Template:Infobox gene Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on ...
  • Template:Infobox gene Neural cell adhesion molecule ( NCAM ), also called CD56 , is a homophilic binding glycoprotein expressed on the surface of neurons , glia and skeletal muscle . (
  • [1] NCAM has been implicated as having a role in cell-cell adhesion, [2] neurite outgrowth, synaptic plasticity, and learning and memory. (
  • Homophilic binding occurs between NCAM molecules on opposing surfaces ( trans- ) and NCAM molecules on the same surface ( cis- )1. (
  • Current models suggest trans- homophilic binding occurs between two NCAM molecules binding antiparallel between all five Ig domains or just IgI and IgII. (
  • NCAM exhibits glycoforms as it can be posttranslationally modified by the addition of polysialic acid (PSA) to the fifth Ig domain, which is thought to abrogate its homophilic binding properties and can lead to reduced cell adhesion important in cell migration and invasion. (
  • The neural cell adhesion molecule (NCAM) and its polysialylated form (PSA-NCAM) contribute to long-term potentiation (LTP) in the CA1 hippocampus. (
  • The neural cell adhesion molecule (NCAM) and its polysialylated form (PSA-NCAM) have been implicated in many aspects of cellular and synaptic plasticity ( 1 - 6 ). (
  • A prevailing view is that the action of PSA-NCAM could be to interfere with the adhesive properties of other adhesion molecules, thus promoting remodeling of synaptic membranes ( 6 , 10 ). (
  • This is the case for various adhesion molecules ( 15 , 16 ), including NCAM ( 7 ), for tissue plasminogen activator ( 17 ), an extracellular protease involved in many aspects of morphogenesis, and for growth factors ( 18 , 19 ). (
  • The present study proposes one explanation concerning the role of adhesion molecules and namely provides evidence that the effects of PSA-NCAM on LTP could result from an interaction with the BDNF signaling cascade. (
  • It is proposed that the role of PSA-NCAM could be to sensitize pyramidal cells to the action of BDNF, and thus promote an activity-dependent regulation of the action of the growth factor on synaptic plasticity ( 29 ). (
  • Prior studies have shown that hippocampal expression of cell adhesion molecules is modified by such stress treatment, with the neural cell adhesion molecule (NCAM) decreasing and L1 increasing, their expression, at both the mRNA and protein levels. (
  • As NCAM-140 is involved in cell-cell adhesion and neurite outgrowth, these findings suggest that this molecule might be one of the molecular mechanisms involved in the complex interactions among neurodegeneration-related events. (
  • One of the identified genes was neural cell adhesion molecule (NCAM). (
  • To investigate the role of NCAM in cardiac cells, we introduced siRNA against NCAM by lentivirus. (
  • In human serum, at least two molecular species of the neural cell adhesion molecule (NCAM) with molecular weights of 110,000-130,000 and 150,000-180,000, respectively, can be identified by Western blotting. (
  • The experimental data clearly show that only the embryonic NCAM molecule carrying the poly-α-(2,8)-linked N -acetylneuraminic acid moiety can be regarded as a specific serum marker for small cell lung cancer. (
  • We previously demonstrated that neural cell adhesion molecule (NCAM) plays an important role in supporting the survival of injured retinal ganglion cells. (
  • In the current study, we used light-induced retinal degeneration (LIRD) as a model to investigate whether NCAM plays a functional role in neuroprotection and whether NCAM influences p75 NTR signaling in modulating retinal cell survival. (
  • 3 The cleavage of the neural cell adhesion molecule (NCAM) has been shown to be involved in cortical neuronal death under oxidative stress, 4 and previous results from our laboratory have demonstrated that NCAM is important in retinal ganglion cell (RGC) survival and age-related deterioration in vision. (
  • In particular, the similarity of the 1H12 antigen to previously published descriptions of neural cell adhesion molecule (NCAM) led us to probe the identity of this antigen more closely. (
  • Examples are LCAM (Liver Cell Adhesion Molecule) and NCAM (Neural Cell Adhesion Molecule), both named from tissues in which first detected, although their occurrence is not in fact restricted to these. (
  • L1 and NCAM, two cell adhesion molecules of the immunoglobulin superfamily, have been implicated in the formation of neural circuits, synaptic plasticity, and cognitive function. (
  • The neural cell adhesion molecule (NCAM) plays important roles in neuronal development, regeneration, and synaptic plasticity. (
  • NCAM exerts these functions by mediating cell-cell and cell-matrix adhesions and by activating intracellular signaling cascades, in which activation of the fibroblast growth factor receptor plays a prominent role. (
  • however, until recently, the putative interaction between NCAM and the epidermal growth factor (EGF) receptor in mammalian cells has not been investigated. (
  • Interestingly, the first study addressing this interaction in mammalian cells points to functional crosstalk between NCAM and the EGF receptor in mammals, which differs strikingly from the functional interplay observed between the Drosophila homologs of these molecules. (
  • Nguyen L, Rigo JM, Malgrange B, Moonen G, Belachew S (2003) Untangling the functional potential of PSA-NCAM-expressing cells in CNS development and brain repair strategies. (
  • Ronn LC, Hartz BP, Bock E (1998) The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system. (
  • Abstract -It has been reported that fibrinogen may act as a bridging ligand, binding to intercellular adhesion molecule-1 (ICAM-1) on human umbilical vein endothelial cells and to Mac-1 on THP-1 cells (a monocytic cell line) to increase adhesion. (
  • Neural Cell Adhesion Molecule L1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (
  • Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. (
  • This graph shows the total number of publications written about "Neural Cell Adhesion Molecule L1" by people in Harvard Catalyst Profiles by year, and whether "Neural Cell Adhesion Molecule L1" was a major or minor topic of these publication. (
  • Below are the most recent publications written about "Neural Cell Adhesion Molecule L1" by people in Profiles. (
  • The primary reason for treatment failure in patients with head and neck squamous cell carcinoma (HNSCC) is local tumor cell invasion. (
  • HNSCC invasion is a necessary component of metastasis where tumor cells infiltrate into adjacent tissues, degrading basement membranes and extracellular matrix (ECM), and -disrupting tissue architecture. (
  • During tumor progression, tumor cells must overcome a hostile microenvironment that can include hypoxia, growth factor deprivation, and loss of adhesion to the ECM. (
  • These cell-cell adhesions are responsible for forming stratifying cell layers, but also influence the differentiated state of the tumor cells, and tend to restrain invasion. (
  • both features are essential for the survival of an invading tumor cell. (
  • Defining the minimal adhesion receptors preserved on cancer cells during tumor progression will define the metastatic adhesion signature. (
  • ICAM-1-dependent anti-invasive cannabinoid effects were confirmed in primary tumor cells from a lung cancer patient. (
  • Central and peripheral nervous system, and other tissues, endothelial cells, and certain tumor cell lines and human cancers including pancreatic cancer, melanoma, renal and colon carcinoma, adrenal gland, placenta, thyroid and testis (Wang et al. (
  • The role of certain integrins in stimulating signal transduction, the essential involvement of integrins in conditioning the function of T and NK cells function, the heterogeneity of integrins and its biological consequences, and the role of cell adhesion molecules in tumor cells invasion and metastases are all extensively analyzed. (
  • EpCAM may thus be an ideal tumor antigen candidate to detect circulating and metastasizing cancer cells by microchip technologies. (
  • Moreover, sALCAM was also shown to inhibit tumor progression in melanoma cells (van Kilsdonk et al. (
  • In contrast to the M r 110,000-130,000 molecule also detectable in serum samples from healthy blood donors, the M r 150,000-180,000 molecule appears to be tumor associated. (
  • Mitchell MJ, Castellanos CA, King MR. Immobilized surfactant-nanotube complexes support selectin-mediated capture of viable circulating tumor cells in the absence of capture antibodies. (
  • Ginkgo biloba extract inhibits tumor necrosis factor-alpha-induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells. (
  • Comparable results were obtained in arterial endothelial cells and in endothelium stimulated with the cytokine tumor necrosis factor-α. (
  • Melanoma metastasis is a multi-step process requiring dynamic changes in cell surface proteins regulating adhesiveness to the extracellular matrix (ECM), stroma, and other cancer cells in varied tumor microenvironments. (
  • Objective- We tested the hypothesis that carvedilol, a β-adrenoceptor and α-adrenoceptor antagonist with potent antioxidant property, could inhibit tumor necrosis factor-α (TNF-α)-induced endothelial adhesiveness to human mononuclear cells (MNCs), an early sign of atherogenesis. (
  • We then tested the hypothesis that carvedilol may reduce tumor necrosis factor-α (TNF-α)-induced intracellular ROS production, redox-sensitive transcription pathway activation, and adhesion molecules expression, resulting in the inhibition of endothelial adhesiveness to human MNCs in vitro-an early sign of atherogenesis. (
  • We measured VCAM1 expression levels in tumor tissues and evaluated its significance and prognostic use in renal cell carcinoma (RCC). (
  • In clear cell RCC, VCAM1 expression levels were apparently high in patients asymptomatic at presentation and in patients with small tumor size, low-stage, low-grade, microvascular invasion-negative, and von Hippel-Lindau alteration-positive tumors. (
  • Renal cell carcinoma (RCC) is the most common malignant tumor of the adult kidney, accounting for ∼3% of human malignancies ( 1 , 2 ). (
  • It is also involved in tumor progression, angiogenesis, and the metastatic process of malignant cells ( 20 , 21 ). (
  • VCAM1 may play a role in tumor cell adhesion to the vascular endothelium, which precedes extravasation of cells and the development of metastases ( 20 , 21 ). (
  • L1CAM downregulation significantly decreased cell motility and invasiveness in lung cancer cells and reduced tumor formation and growth in mice. (
  • The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. (
  • Unlike other adhesion receptors, selectins bind to carbohydrates and glycopeptides rather than protein ligands (table 2 ). (
  • NrCAM is a cell surface protein of the immunoglobulin superfamily, L1/neurofascin/NgCAM subgroup. (
  • The molecule is 200-220kDa transmembrane protein, which contains 5 fibronectin type-III domains, 6 Ig-like C2-type (immunoglobulin-like) domains in the extracellular region and a highly conserved cytoplasmic tail. (
  • ALCAM protein is localized to the cell membrane (Bowen et al. (
  • JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1. (
  • MAGI-1 is a membrane-associated guanylate kinase protein at tight junctions in epithelial cells. (
  • It interacts with various molecules and functions as a scaffold protein at cell junctions. (
  • We report here a novel MAGI-1-binding protein that we named junctional adhesion molecule 4 (JAM4). (
  • Here we report that this protein is also expressed during lactation by mammary epithelial cells. (
  • Immunohistochemistry of mammary glands using antisera directed against GlyCAM 1 peptides demonstrates that these epithelial cells contain GlyCAM 1 protein, and that this protein is also found lumenally in the milk of the secreting mammary gland. (
  • OBJECTIVE To assess prospectively the prognostic value of soluble cellular adhesion molecules (CAMs) in patients with unstable angina and non-Q wave myocardial infarction and to compare their prognostic accuracy with that of C reactive protein (CRP). (
  • Nectin is a Ca 2+ -independent homophilic immunoglobulin-like adhesion molecule, and l-afadin is an actin filament-binding protein that connects the cytoplasmic region of nectin to the actin cytoskeleton. (
  • The purposes of this study were to assess whether anti-oxidized LDL antibody titers are related to other inflammatory markers of possible interest in atherosclerotic development, such as soluble cell adhesion molecules, interleukin-6, and C-reactive protein (CRP), and to determine the prognostic value of anti-oxidized LDL antibody as a predictor of cardiac events in patients with unstable angina pectoris. (
  • Screening expressed sequence tag databases for endothelial-specific homologs to human junctional adhesion molecule (JAM) and A33-Ag, we identified a protein of 298 aa that represents the recently described vascular endothelial-JAM (VE-JAM)/JAM 2. (
  • With these understandings, we have characterized a protein-interacting pair that can be important in the role of T, NK, and dendritic cell trafficking and inflammation. (
  • A gene located on chromosome 19q13.3 that encodes a protein belonging to the immunoglobulin superfamily, which is an endothelial cell-adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1, L-selectin and VLA-4 on myeloid cells to direct leukocytes into mucosal tissue (e.g., into Peyer patches and intestinal lamina propria) and into inflamed tissues. (
  • Recognizes a cell surface protein of 220-240 kDa, identified as L1 cell adhesion molecule. (
  • Monoclonal antibodies raised against Algal-CAM, a fasciclin-like adhesion protein, prevent appropriate cell-cell contacts of the four-cell Volvox carteri embryo ( Huber and Sumper, 1994 ). (
  • Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. (
  • In addition, ALCAM-ALCAM homophilic interaction contributes to cellular changes, such as angiogenesis, immune response and cell migration during the neuronal development (van Kempen et al. (
  • It has been suggested that cadherins bind cells by their homophilic interactions at the extracellular domain and are associated with actin bundles at the cytoplasmic domain. (
  • L1-dependent cell-cell adhesion is mediated by the homophilic binding between L1 molecules located on adjacent cells. (
  • JAM4 mediated calcium-independent homophilic adhesion and was accumulated at cell-cell contacts when expressed in L cells. (
  • Soluble cell adhesion molecules (sCAMs) are a class of cell adhesion molecule (CAMs - cell surface binding proteins) that may represent important biomarkers for inflammatory processes involving activation or damage to cells such as platelets and the endothelium. (
  • Many studies have postulated that increased production of cell adhesion molecules (CAMs) on the vascular endothelium (blood vessel lining) plays a role in the development of arterial plaque, with the suggestion from both in vitro and in vivo studies that the CAM production is increased by dyslipidemia (abnormal lipid levels in the blood). (
  • L1-deficient DCs derived from these mice were impaired in both adhesion to the endothelium and in transendothelial migration. (
  • Background: Soluble adhesion molecules are involved in the gathering and joining of inflammatory cells to vascular endothelium. (
  • Therapeutic molecules conjugated with antibodies to the platelet-endothelial cell adhesion molecule-1 (PECAM-1) accumulate in the pulmonary endothelium after i.v. injection in mice. (
  • Therefore, the lack of effective, rapid, and safe targeting of therapeutic molecules to endothelium represents an important biomedical problem. (
  • 4 Local inflammatory cells generate and release cytokines, which activate endothelium, transforming its natural antiadhesive and anticoagulant properties. (
  • Endothelium and adhesion molecules are engaged in the pathogenesis of rheumatoid arthritis (RA). (
  • AU - Klimiuk,P A, AU - Sierakowski,S, AU - Domyslawska,I, AU - Chwiecko,J, PY - 2009/11/20/entrez PY - 2009/11/20/pubmed PY - 2009/12/16/medline SP - 439 EP - 44 JF - Scandinavian journal of rheumatology JO - Scand J Rheumatol VL - 38 IS - 6 N2 - OBJECTIVE: Endothelium and adhesion molecules are engaged in the pathogenesis of rheumatoid arthritis (RA). (
  • Cell adhesion molecules (CAMs) cause adhesion of leucocytes to the endothelium prior to their subsequent extravasation into inflamed tissue. (
  • Fibrinogen and its degradation products stimulate the release of several growth factors and urokinase plasminogen activator (uPA) from endothelial cells 7 8 and can promote an increase the vascular permeability and disorganization of the endothelium. (
  • In the early phase of atherogenesis, cell surface adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1), intercellular cell adhesion molecule-1 (ICAM-1), and endothelial cell selectin (E-selectin) could express on endothelial cells to recruit circulating mononuclear cells (MNCs), mainly monocytes, and facilitate their binding to endothelium and migrating to subendothelial space. (
  • Three main groups of adhesion molecules have been implicated in cardiovascular pathology: integrins, selectins, and members of the immunoglobulin superfamily. (
  • The β 2 integrins are expressed solely by white cells and principally interact with members of the immunoglobulin superfamily promoting leucocyte adhesion and infiltration. (
  • Schematic representations of integrin (left), immunoglobulin superfamily (centre), and selectin (right) adhesion molecule structures. (
  • A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. (
  • We have recently identified a novel gene, hepaCAM, in liver that encodes a cell adhesion molecule of the immunoglobulin superfamily. (
  • This review provides a brief description of five families of CAMs (cadherins, integrins, CD44, immunoglobulin superfamily, and selectins) and highlights their altered expression in relation both to prognosis and tumour behaviour in squamous cell carcinoma and adenocarcinoma of the oesophagus. (
  • Biliary glycoprotein (BGP) is the human homologue of a cell adhesion molecule (CAM) of the rat designated Cell-CAM. (
  • Activation of the α IIb β 3 or glycoprotein IIb/IIIa receptor is the final step in platelet aggregation and determines the adhesion of platelets to other matrix and plasma proteins. (
  • Initially described as a dominant surface antigen on human colon carcinoma, it is a transmembrane glycoprotein mediating epithelial-specific intercellular cell-adhesion. (
  • L1 (also known as L1CAM or CD171) is a transmembrane glycoprotein belonging to the Ig superfamily of cell adhesion molecules (CAMs [Ig-CAMs]), which mediate calcium-independent cell-cell adhesion. (
  • Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) is a mucinlike endothelial glycoprotein that acts as an adhesive ligand for L selectin by presenting one or more O-linked carbohydrates to the lectin domain of this leukocyte cell surface selectin. (
  • The GlyCAM 1 glycoprotein has been previously shown to be expressed specifically by the endothelial cells of peripheral and mesenteric lymph nodes and in an unknown site in lung. (
  • In addition, the finding that the mammary form of GlyCAM 1 contains different carbohydrate modifications than the endothelial form suggests that this glycoprotein may be a scaffold for carbohydrates that mediate functions in addition to cell adhesion. (
  • Biochemical analyses revealed that hepaCAM is an N-linked glycoprotein phosphorylated in the cytoplasmic domain and that it forms homodimers through cis-interaction on the cell surface. (
  • Damjanov, Developmentally regulated expression of the cell-cell adhesion glycoprotein cell-CAM 120/80 in peri-implantation mouse embryos and extraembryonic membranes. (
  • Damsky, Identification and purification of a cell surface glycoprotein mediating intercellular adhesion in embryonic and adult tissue. (
  • Vascular cell adhesion molecule 1 (VCAM1) is a cell surface glycoprotein implicated in various pathophysiologic conditions. (
  • The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. (
  • Our group previously identified L1 cell adhesion molecule (L1CAM) expression as a member of a prognostic multigene expression signature for NSCLC patients. (
  • However, there is little information on the biologic function of L1CAM in lung cancer cells. (
  • L1CAM expression was suppressed by short-hairpin RNA (shRNA)-mediated silencing in human NSCLC cell lines. (
  • Cells with L1CAM downregulation were deficient in constitutive extracellular signal-regulated kinase (Erk) activation. (
  • Orthotopic studies showed that L1CAM suppression in highly metastatic lung cancer cells significantly decreases spread to distant organs, including bone and kidney. (
  • We also confirm that L1CAM is a poor prognostic marker for patients with NSCLC and plays a significant role in promoting invasiveness and motility of NSCLC cells. (
  • One such molecule, L1 cell adhesion molecule (L1CAM), is aberrantly expressed in several cancer types, including ovarian ( 9 ), melanoma ( 10 ), breast ( 11 ), pancreatic ( 12 ), and colon cancers ( 13 ). (
  • The extracellular region of L1CAM binds to a diverse range of proteins that include L1CAMs themselves, other cell surface proteins such as integrins and axonin1, and extracellular matrix proteins such as laminin and neurocan ( 15, 16 ). (
  • L1CAM function has been most extensively studied in the nervous system, where it is known to orchestrate morphogenetic events such as neuron-neuron adhesion, axon guidance, neurite outgrowth, neurite fasciculation, and myelination ( 15 , 17 ). (
  • A second class of receptors expressed in HNSCC, the cadherins, form intercellular adhesions and are also relevant to the invasive process. (
  • There are four major superfamilies or groups of CAMs: the immunoglobulin super family of cell adhesion molecules (IgCAMs), Cadherins, Integrins, and the Superfamily of C-type of lectin-like domains proteins (CTLDs). (
  • The classic cadherins (E-, N- and P-) are concentrated at the intermediate cell junctions, which link to the actin filament network through specific linking proteins called catenins. (
  • Cadherins are a family of glycoproteins involved in the Ca2+-dependent cell-cell adhesion mechanism which is detected in most kinds of tissues. (
  • Their colony morphology was altered by the ectopic expression of cadherins from the dispersed type to the compact type, providing direct evidence for a key role of cadherins in cell-cell adhesion. (
  • Cell adhesion - Cellular adhesion is the binding of a cell to a surface, extracellular matrix or another cell using cell adhesion molecules such as selectins, integrins, and cadherins. (
  • Deregulated expression of members of all major cell adhesion molecule families [integrins, selectins, cadherins, and the immunoglobulin (Ig) superfamily] is frequently reported in human cancers ( 8 ). (
  • Cavallaro U, Christofori G (2004) Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. (
  • Growth cones express various cell adhesion molecules (CAMs) that recognize localized guidance cues present on neighboring cells or in the extracellular matrix and translate them into a directed axonal extension ( Tessier-Lavigne and Goodman, 1996 ). (
  • Cell adhesion molecules (CAMs) are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion. (
  • Combined with cell junctions and ECM, CAMs help hold animal cells together. (
  • They are also capable of heterophilic binding, meaning a CAM on one cell will bind with different CAMs on another cell. (
  • The final type of binding occurs between cells and substrate, where a mutual extracellular ligand that binds two different CAMs. (
  • Drenjancevic, "The effects of arterial blood pressure reduction on endocan and soluble endothelial cell adhesion molecules (CAMs) and CAMs ligands expression in hypertensive patients on ca-channel blocker therapy," Kidney and Blood Pressure Research, vol. (
  • The inflammatory cytokines generated induce increased expression of cellular adhesion molecules (CAMs). (
  • Formation of inflammatory lesions, one of the pathologic consequences of infection with Trypanosoma cruzi , involves intricate cell-cell interactions in which cell adhesion molecules (CAMs) are involved. (
  • Our results indicate that cCAMs may reflect an upregulation of CAMs on endothelial and epithelial airway cells in COPD. (
  • Distinct proteins known as cell adhesion molecules (CAMs) mediate these interactions. (
  • Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. (
  • In the third step, CEA upregulates cell adhesion molecules for metastasis [9]. (
  • Here we will highlight recent literature to underscore how cell adhesion molecules (CAM) contribute to melanoma disease progression and metastasis. (
  • Metastasis is associated with profound changes in cellular properties, including the disruption of cell-cell and cell-matrix adhesions and the acquisition of migratory abilities. (
  • The DNA molecules encoding these proteins have use in gene therapy regimes. (
  • We generated vascular cell adhesion molecule (VCAM)-1 "knock-in" mice and Cre recombinase transgenic mice to delete the VCAM-1 gene ( vcam-1 ) in whole mice, thereby overcoming the embryonic lethality seen with conventional vcam-1 -deficient mice. (
  • VCAM-1 (vascular cell adhesion molecule-1) gene expression inhibitor - Pipeline Insight, 2018" report by DelveInsight offers comprehensive insights of the pipeline (under development) therapeutics scenario and growth prospects across "VCAM-1 (vascular cell adhesion molecule-1) gene expression inhibitor development. (
  • Descriptive coverage of pipeline development activities for "VCAM-1 (vascular cell adhesion molecule-1) gene expression inhibitor - Pipeline therapeutics development coverage provides descriptive product profiles including (but not limited to) drug description, product development and R&D activities encompassing clinical and pre-clinical studies, designations, collaborations, licensing deals, grants, technologies and patent details. (
  • The report assesses the active VCAM-1 (vascular cell adhesion molecule-1) gene expression inhibitor pipeline products by developmental stage, product type, molecule type, and administration route. (
  • Offers detailed therapeutic product profiles of VCAM-1 (vascular cell adhesion molecule-1) gene expression inhibitor with key coverage of developmental activities including licensing & collaboration deals, patent details. (
  • These findings indicate that a different Ca2+-dependent cell adhesion molecule, perhaps another member of the cadherin gene family, is responsible for the Ca2+-dependent adhesion between cleavage stage Xenopus blastomeres. (
  • In addition, integrins participate in cell-matrix interactions, while other CAM families participate in cell-cell interactions. (
  • citation needed] Integrins, one of the major classes of receptors within the ECM, mediates cell-ECM interactions with collagen, fibrinogen, fibronectin, and vitronectin. (
  • Integrins provide essential links between the extracellular environment and the intracellular signalling pathways, which can play roles in cell behaviours such as apoptosis, differentiation, survival, and transcription. (
  • 2 The most widely distributed integrins belong to the β 1 subfamily, which mainly influence the adhesion of cells to extracellular matrix proteins such as fibronectin, collagens, and laminin (table 1 ). (
  • They induce relatively weak and transient adhesion allowing the cells to roll along the vascular wall after which they will disengage or, following the triggering of other adhesion receptors such as integrins, become more securely bound. (
  • They determine a variety of lymphocyte functions but, perhaps more importantly in the context of cardiovascular disease, they also play a pivotal role in the "trafficking" of leucocytes through tissues, interacting with β 2 integrins on white cells. (
  • The molecular basis for the regulation of certain integrins, the function of these proteins in determining cell adhesion, and the consequences of this adhesion for the function of the cells involved are discussed. (
  • Samples were processed for qRT-PCR (Prism 7700, Applied Biosystems) to quantify mRNA expression of coxsackie adenovirus receptor (CAR) and integrins αV, ß3 and ß5, which have been shown to play a role in cell surface interaction and internalization of viral vector during the transduction process. (
  • It also operates as a receptor for several different neuronal recognition molecules. (
  • We found that polysialylated neural cell adhesion molecule-immunoreactivity within the amygdala, present in somata and neuronal processes, has a regional gradient with the central medial and medial amygdaloid nuclei showing the highest levels. (
  • Ditlevsen DK, Kohler LB, Pedersen MV, Risell M, Kolkova K, Meyer M, Berezin V, Bock E (2003) The role of phosphatidylinositol 3-kinase in neural cell adhesion molecule-mediated neuronal differentiation and survival. (
  • Amoureux M-C, Cunningham BA, Edelman GM, Crossin KL (2000) N-CAM binding inhibits the proliferation of hippocampal progenitor cells and promotes their differentiation to a neuronal phenotype. (
  • However, growing evidence indicates that cell-adhesion molecules also play important and diverse roles in regulating synaptic plasticity and learning and memory. (
  • This review focuses on recent advances in understanding the molecular mechanisms through which adhesion molecules might regulate synaptic plasticity. (
  • Although the contribution of these molecules to synaptic plasticity adds support to the idea that LTP involves both functional and structural modifications, the mechanisms through which these molecules participate to LTP remain unclear. (
  • Ronn LC, Berezin V, Bock E (2000) The neural cell adhesion molecule in synaptic plasticity and ageing. (
  • Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility. (
  • Two distinct calcium-sensitive cell-cell adhesion molecules were identified in human epithelial tissues and carcinomas using two monoclonal antibodies raised against vulvar epidermoid carcinoma A-431 and human mammary carcinoma MCF-7 and selected on the basis of their activities to disrupt cell-cell adhesion. (
  • Inhibition of the cadherin activity with antibodies induces dissociation of cell layers, indicating a fundamental importance of these molecules in maintaining the multicellular structure. (
  • Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications. (
  • Vascular immunotargeting, a strategy based on conjugation of a diagnostic or therapeutic molecule with antibodies directed against specific endothelial surface determinants, may help to solve the problem ( Muzykantov, 1998 ). (
  • Mouse anti-human monoclonal antibodies against vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and E-selectin were obtained from Becton-Dickinson, and isotype mouse IgG1 and IgG2 not directed against endothelial cell antigens were obtained from ICN Immunobiologicals. (
  • Although this could mean any molecule involved in cellular adhesive phenomena, it has acquired a more restricted sense, namely a molecule on the surface of animal tissue cells, antibodies (or Fab fragments) against which specifically inhibit some form of intercellular adhesion. (
  • They include soluble isoforms of the cell adhesion molecules ICAM-1, VCAM-1, E-selectin and P-selectin (distinguished as sICAM-1, sVCAM-1, sE-selectin and sP-selectin). (
  • This study investigates the role of intercellular adhesion molecule-1 (ICAM-1) within this action. (
  • Overall, our data indicate that cannabinoids induce ICAM-1, thereby conferring TIMP-1 induction and subsequent decreased cancer cell invasiveness. (
  • VCAM-1 expression can be induced by numerous factors, including TNF-α, IL-1, IL-4, IL-13, and intercellular adhesion molecule (ICAM)-1 cross-linking ( 8 )( 9 )( 10 )( 11 )( 12 )( 13 )( 14 ). (
  • Immunoglobulin molecules such as the intercellular adhesion molecules (ICAM-1, 2, and 3), vascular cell adhesion molecule 1 (VCAM-1), and platelet endothelial cell adhesion molecule 1 (PECAM-1) are principally involved in the adhesion of leucocytes (table 2 ). (
  • 4 ICAM-1 and 2 are expressed on endothelial cells, lymphocytes, and some other leucocytes. (
  • Cytokine-regulated expression of E-selectin, intercellular adhesion molecule -1 (ICAM-1) & vascular cell adhesion molecules -1 (VCAM-1) in human intestinal microvascular endothelial cells, J Immunol, 156: 2558-65. (
  • The angiogenic factors soluble fms-like tyrosine kinase-1 (sFLT-1), intercellular cell adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) are known to be associated with endothelial dysfunction, vascular remodeling, and hypertension. (
  • This study demonstrates that anti-oxidized LDL antibody expression is associated with the expression of CRP and adhesion molecules, especially ICAM-1, and is a predictor of cardiac events in patients with unstable angina pectoris. (
  • disease patients grouped according to disease severity were studied for the presence of soluble intercellular adhesion molecule-1 (s-ICAM-1), soluble endothelial selectin (s-E-selectin), soluble vascular cell adhesion molecule-1 (s-VCAM-1), soluble platelet selectin (s-P-selectin), and s-CD44 were studied to determine if they could be used alone or in different combinations as markers for specific diagnostic procedures. (
  • E-selectin, intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 were studied in nasal mucosal biopsies taken during a time-course provocation study, including patients with seasonal allergic rhinitis and healthy controls. (
  • intercellular adhesion molecule 1 - (ICAM 1) a type of cell adhesion molecule that contains five immunoglobulin like domains and is expressed on a variety of cells, including B and T lymphocytes, fibroblasts, keratinocytes, and endothelial cells. (
  • In this study, we investigated whether fibrinogen altered the expression of ICAM-1 and, thus, increased the adhesion of THP-1 cells to cultured human saphenous vein endothelial cells (HSVECs). (
  • This fibrinogen-stimulated ICAM-1 upregulation was associated with a 2-fold increase in THP-1 cell adhesion to HSVECs. (
  • 8 9 The rapid and sustained increase in intercellular adhesion molecule-1 (ICAM-1) expression in human umbilical vein endothelial cells (HUVECs) cultured in the presence of fibrin 10 could potentiate a number of cellular events mediated through this adhesion molecule. (
  • The role of fibrinogen as a bridging ligand was attributed to binding of the γ117-133 sequence of the fibrinogen D domain to ICAM-1 on endothelial cells. (
  • The present study was undertaken to determine the effect of the daily consumption of low-calorie cranberry juice cocktail on plasma OxLDL, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin concentrations in men. (
  • Gallin, Sequence analysis of a cDNA clone encoding the liver cell adhesion molecule, L-CAM. (
  • Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) is preferentially expressed on the endothelial lining of blood vessels in the lymphoid tissue of the bowel. (
  • In other eukaryotes (e.g. fruitfly [ Drosophila melanogaster ] and humans [ Homo sapiens ]), fasciclin domain-containing proteins are involved in cell adhesion. (
  • The removal of PSA prior to LIRD induced earlier onset of retinal cell death, an effect delayed by the coadministration of endoneuraminidase-N and the p75 NTR function-blocking antibody antiserum. (
  • Finally, in adherence assays, Jurkat cell binding to resting FLS monolayers was inhibited by antibody to alpha 4/beta 1 integrin (VLA-4), CS-1 peptide from alternatively spliced fibronectin (which is another VLA-4 ligand), and, to a lesser extent, anti-VCAM-1 antibody. (
  • Furthermore, the DHT-related increase in adhesion was completely blocked by coincubation with anti-VCAM-1 antibody. (
  • E-Cadherin was identified in the Xenopus A6 epithelial cell line by antibody cross-reactivity and several biochemical characteristics. (
  • Behrens, Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin. (
  • Serum levels of soluble vascular cell adhesion molecules may correlate with the severity of dengue virus-1 infection in adults," Emerging Microbes & Infections, vol. (
  • This study was undertaken to analyse the effect of etanercept on the levels of soluble cell adhesion molecules (sCAMs) and vascular endothelial growth factor (VEGF) in patients with active RA. (
  • Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), E-selectin (sE-selectin), and VEGF were measured by enzyme-linked immunosorbent assay (ELISA) in 18 RA patients (prior to injection) at 0, 3, 6, 9, and 12 months. (
  • Cell adhesion molecules are key regulators of atherosclerotic plaque development, but circulating levels of soluble fragments, such as intercellular adhesion molecule (sICAM-1) and vascular cell adhesion molecule (sVCAM-1), have yielded conflicting associations with atherosclerotic cardiovascular disease (ASCVD). (
  • Compared with control condition, pretreatment of carvedilol (10 μmol/L for 18 hours) or probucol (5 μmol/L for 18 hours), but not propanolol, prazosin, or both propanolol and prazosin significantly decreased TNF-α-stimulated adhesiveness of cultured human aortic endothelial cells (HAECs) to MNCs. (
  • ALCAM (Activated Leukocyte Cell Adhesion Molecule), also known as CD166 (cluster of differentiation 166), is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. (
  • Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system. (
  • Epithelial cell adhesion molecule expression (CD326) in cancer: a short review. (
  • Epithelial cell adhesion molecule (EpCAM, CD326) is a pleiotropic molecule that potentially offers therapeutic applications in cancer treatment. (
  • In this work CUR-NPs (curcumin-loaded lipid-polymer-lecithin hybrid nanoparticles) were synthesized and functionalized with ribonucleic acid (RNA) Aptamers (Apts) against epithelial cell adhesion molecule (EpCAM) for targeted delivery to colorectal adenocarcinoma cells. (
  • The expression and clinical significance of epithelial cell adhesion molecule in gastric cancer. (
  • Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer," Gynecologic Oncology, vol. (
  • The expression of the Ca2+-dependent epithelial cell adhesion molecule E-cadherin (also known as uvomorulin and L-CAM) in the early stages of embryonic development of Xenopus laevis was examined. (
  • Gallin, Characterization of L-CAM, a major cell adhesion molecule from embryonic liver cells. (
  • Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. (
  • In this volume, the expression of specific adhesion molecules within human cancer tissues are highlighted. (
  • Later in development, NCAM1 (CD56) expression is found on various differentiated tissues and is a major CAM mediating adhesion among neurons and between neurons and muscle. (
  • Normal cells that stain positively for CD56 include NK cells , activated T cells , the brain and cerebellum , and neuroendocrine tissues. (
  • It contains the consequent analysis of the injury and defensive responses as regards separate cells, organs and tissues and the whole organism. (
  • Indeed, upon microbial contact and stimulation by inflammatory cytokines DCs take up antigens and migrate from peripheral tissues, via the afferent lymphatics, into the T cell area of the draining lymph node where they present the antigens to T lymphocytes, thus triggering the immune response. (
  • The migration of DCs into and out of tissues depends on a cascade of discrete events including the induction of chemokines, the activation of chemokine receptors, and the regulation of adhesion molecules. (
  • Natalie Dye highlights a recent preprint from Yu Sun and colleagues, describing how a new way of measuring the mechanical properties of bulk tissues in vivo identifies a stiffness gradient in the developing limb that correlates with patterns of cell migration. (
  • All four mAbs recognized the same polypeptides in A6 cells, adult epithelial tissues, and embryos. (
  • The initial phase of inflammation in bronchial asthma appears to be triggered by the expression of leucocyte-endothelial adhesion molecules on endothelial cell surfaces. (
  • Before provocation allergic patients and controls did not differ concerning the expression of endothelial adhesion molecules. (
  • Owing to the importance of monocyte adhesion to endothelial cells in the development of atherosclerosis, we hypothesized that androgens might promote this process. (
  • Conclusions -Androgen exposure is associated with increased human monocyte adhesion to endothelial cells, a proatherogenic effect mediated at least in part by an increased endothelial cell-surface expression of VCAM-1. (
  • Monocyte adhesion to endothelial cells is an important early event in atherogenesis, controlled in part by expression of adhesion molecules on the endothelial cell surface. (
  • Recent data suggest that EpCAM is also involved in cell signaling, migration, proliferation and differentiation. (
  • Testing for EpCAM is based on morphology and phenotypical staining and can be performed with primary carcinoma tissue and cells harvested from malignant effusions. (
  • Stable or highly expressed EpCAM has been detected in most adenocarcinomas and has also been found in metastases, malignant effusions, and cancer stem cells. (
  • These results show that the EpCAM Apt-functionalized CUR-NPs enhance the targeting and drug delivery of CUR to colorectal cancer cells. (
  • The adhesion of cells to each other and to the proteins of the extracellular matrix provides a stable environment for cell growth, differentiation, and migration. (
  • There is, therefore, increasing interest in the receptors that determine these processes-cell adhesion molecules. (
  • When neural crest cells stop making N-CAM and N-cadherin , and start displaying integrin receptors , cells separate and migrate. (
  • In order to identify amygdala nuclei which may be affected under chronic stress conditions we evaluated the effects of 21-days chronic restraint stress on the expression of a molecule implicated crucially in alterations in structural plasticity: the polysialylated neural cell adhesion molecule. (
  • Kiss JZ, Troncoso E, Djebbara Z, Vutskits L, Muller D (2001) The role of neural cell adhesion molecules in plasticity and repair. (
  • Gicerin/CD146 is involved in neurite extension of NGF-treated PC12 cells. (
  • They are likely to contribute to cell migration, neurite outgrowth, axon elongation, and synapse formation ( 6 , 7 ). (
  • In addition, several molecules involved during development in neurite outgrowth and synapse formation have been implicated in LTP. (
  • L1 has long been characterized as a cell recognition molecule within the nervous system, where it is involved in neurite fasciculation, synaptogenesis, axonal growth and path finding, and cell migration. (
  • Kiryushko D, Berezin V, Bock E (2004) Regulators of neurite outgrowth: role of cell adhesion molecules. (
  • In these epithelial tumors, cadherin engagement can promote cell survival by a process termed "synoikis" that involves the receptor tyrosine kinase, EGFR. (
  • Purified tryptic fragments of the antigen recognized by NCC-CAD-299 showed cross-reactivity with a rabbit antiserum against mouse P-cadherin, indicating that this molecule was the human homologue of P-cadherin. (
  • On the other hand, the antigen recognized by HECD-1 showed essentially the same tissue distribution pattern as E-cadherin in the mouse, suggesting that this molecule is the human homologue of E-cadherin. (
  • Moreover, immunohistochemical examination of 44 lung carcinomas showed that both molecules were coexpressed in all of them, and suggested that expression of P-cadherin was closely related to the differentiation of carcinoma cells. (
  • L cells, with very little endogenous cadherin activity, transfected with the cadherin cDNA acquired high cadherin-mediated aggregating activity. (
  • It appears that each cadherin subclass has binding specificity and this molecular family is involved in selective cell-cell adhesion. (
  • e.g. the termination or initiation of expression of a cadherin subclass in a given cell collective is correlated with its segregation from or connection with other cell collectives. (
  • The cell adhesion molecules N-cadherin and neural cell adhesion molecule regulate human growth hormone: a novel mechanism for regulating pituitary hormone secretion. (
  • We have found a new cell-cell adhesion system at cadherin-based cell-cell adherens junctions (AJs) consisting of at least nectin and l-afadin. (
  • Here, we examined the mechanism of interaction between these two cell-cell adhesion systems at AJs by the use of α-catenin-deficient F9 cell lines and cadherin-deficient L cell lines stably expressing their various components. (
  • Nectin trans-interacted independently of E-cadherin, and the complex of E-cadherin and α- and β-catenins was recruited to nectin-based cell-cell adhesion sites through l-afadin without the trans-interaction of E-cadherin. (
  • Our results indicate that nectin and cadherin interact through their cytoplasmic domain-associated proteins and suggest that these two cell-cell adhesion systems cooperatively organize cell-cell AJs. (
  • In polarized cells, hepaCAM is recruited to the lateral and basal membranes, and lacking physical interaction, hepaCAM is shown to co-localize with E-cadherin at the lateral membrane. (
  • Choi YS and Gumbiner B (1989), Expression of cell adhesion molecule E-cadherin. (
  • Expression of cell adhesion molecule E-cadherin in Xenopus embryos begins at gastrulation and predominates in the ectoderm . (
  • Hatta, Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development. (
  • 10 11 We therefore aimed to explore the effects of the potent nonaromatizable androgen dihydrotestosterone (DHT) on monocyte-endothelial cell adhesion and on the expression of endothelial cell adhesion molecules using primary human cells. (
  • VCAM-1 was originally identified on the surface of activated human umbilical vein ECs as a mediator of adhesion with melanoma cells and lymphocytes ( 8 )( 9 )( 10 ). (
  • Carter WG, Ryan MC, Gahr PJ (1991) Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes. (
  • In our functional characterizations of VE-JAM/JAM 2, we discovered that it can function as an adhesive ligand for the T cell line J45 and can interact with GM-CSF/IL-4-derived peripheral blood dendritic cells, circulating CD56 + NK cells, circulating CD56 + CD3 + NK/T cells, and circulating CD56 + CD3 + CD8 + cytolytic T cells. (
  • The demonstration that fibrinogen acts as a bridging ligand for adhesion of THP-1 cells (a monocytic cell line) to cultured HUVECs 12 could signify a potential mechanism for the promotion of monocyte infiltration into the vascular wall. (
  • Alt-Holland A, Zhang W, Margulis A, Garlick JA (2005) Microenvironmental control of premalignant disease: the role of intercellular adhesion in the progression of squamous cell carcinoma. (
  • Soluble forms of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin (termed sICAM-1, sVCAM-1 and sE-selectin respectively) are found in the plasma, and are elevated during inflammatory conditions in which there is increased expression of the cellular forms of the molecules on endothelial and other cells. (
  • In addition to serving as "molecular glue", cell adhesion is important in affecting cellular mechanisms of growth, contact inhibition, and apoptosis. (
  • The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto, Italy, June 24-26, 1992 and was focussed on the detailed mechanisms whereby cells utilize certain integral membrane proteins to perceive their surrounding environment and interact with it. (
  • The in vitro specific cell binding, cellular uptake, and cytotoxicity of Apt-CUR-NPs were also studied. (
  • One of the players in this scenario is vascular cell adhesion molecule (VCAM)-1, which mediates both rolling on endothelial cells (ECs) and firm adherence ( 4 )( 5 )( 6 )( 7 ). (
  • ALCAM-CD6 interaction mediates T-cell activation or proliferation. (
  • Concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble endothelial selectin, and soluble platelet selectin were measured using an enzyme linked immunosorbent assay technique. (
  • Wright C, Leyden R, Murphy PV, Callaghan M, Velasco-Torrijos T, McClean S. Inhibition of Burkholderia multivorans Adhesion to Lung Epithelial Cells by Bivalent Lactosides. (
  • L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis. (
  • Krushel LA, Tai MH, Cunningham BA, Edelman GM, Crossin KL (1998) Neural cell adhesion molecule (N-CAM) domains and intracellular signaling pathways involved in the inhibition of astrocyte proliferation. (
  • Endothelial cell adhesion molecules in inflammation and postischemic reperfusion injury. (
  • Inflammation, cell adhesion molecules, and stroke: tools in pathophysiology and epidemiology? (
  • VCAM-1 on HEVs has an apparently redundant role in lymphocyte migration to LNs ( 24 ), whereas VCAM-1 on BM microvessels has an overlapping role with selectins in hematopoietic progenitor cell recruitment into the BM compartment ( 7 )( 34 ). (
  • Your search returned 2149 cell adhesion molecule ELISA ELISA Kit across 28 suppliers. (
  • Your search returned 120 carcinoembryonic antigen related cell adhesion molecule 5 ELISA ELISA Kit across 18 suppliers. (
  • Plasma OxLDL and adhesion molecule concentrations were measured by ELISA before and after each phase. (
  • Betson M, Lozano E, Zhang J, Braga VM (2002) Rac activation upon cell-cell contact formation is dependent on signaling from the epidermal growth factor receptor. (
  • Cranberry juice supplementation reduces cholesterol oxidation and cell adhesion molecule concentrations in men. (
  • Bivalent lactosides previously shown to inhibit galectin binding significantly reduced the attachment of B. multivorans to CF lung epithelial cells at micromolar concentrations. (
  • Low-calorie cranberry juice supplementation reduces plasma oxidized LDL and cell adhesion molecule concentrations in men. (
  • Elevated circulating concentrations of oxidized LDL (OxLDL) and cell adhesion molecules are considered to be relevant markers of oxidative stress and endothelial activation which are implicated in the development of CVD. (
  • May inhibit cell growth through suppression of cell proliferation. (
  • This is seemingly in contrast to studies with BM stromal cell clones from VCAM-1 null mice, where long-term maintenance and proliferation of clonable pre-B cells, cobblestone formation, and differentiation to IgM-secreting mature B cells were equally possible on VCAM-1 + and VCAM-1 − BM stromal cells ( 35 ). (
  • Adhesive interactions, however, are also involved in the pathogenesis of cardiovascular disease, regulating thrombus formation, facilitating leucocyte infiltration, mediating the migration and proliferation of smooth muscle cells, and enabling the deposition of fibrotic tissue. (
  • We previously reported that cell-cell interaction between lymphoma cells and macrophages induces lymphoma cell proliferation. (
  • Significant cell-cell interaction between macrophages and ATN-1, ATL-T, ATL-35T and MT-2, DAUDI, and SLVL cells, as assessed by induction of cell proliferation, was observed. (
  • 1 2 3 4 Along with the excessive proliferation of intimal smooth muscle cells, leukocyte infiltration is a major histological feature of flow-limiting stenoses in saphenous vein bypass grafts. (
  • 9,12 Recently, carvedilol was shown to reduce low-density lipoprotein oxidation in vitro 13,14 and inhibit smooth muscle cell migration, proliferation, or neointimal formation after vascular injury in vivo. (
  • Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. (
  • Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. (
  • Identification of JAM 3 was done by transiently transfecting pooled cDNA libraries encoding secreted and transmembrane proteins into COS cells grown on glass chamber slides. (
  • S. S. Signorelli, M. C. Mazzarino, and D. A. Spandidos, "Malaponte G. Proinflammatory circulating molecules in peripheral arterial disease," International Journal of Molecular Medicine , vol. 20, pp. 279-286, 2007. (
  • The formation of filament bundles is a novel and unexpected property of polysialic acid and of short carbohydrate oligomers in general and represents a previously unrecognized molecular interaction mechanism which impacts both eukaryotic and prokaryotic cell-cell adhesions. (
  • The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex. (
  • The recent discovery and description of junctional adhesion molecule (JAM) 2 and A33-Ag introduced a new subfamily of Ig-like adhesion molecules to the study of epithelial biology and tight junction regulations. (
  • Up-regulation of carcinoembryonic antigen-related cell adhesion molecule 1 in gastrointestinal cancer and its clinical relevance. (
  • The different expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and possible roles in gastric carcinomas," Pathology--Research and Practice, vol. (
  • Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2). (