A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe. Structurally, they include small peptides, proteins, and glycoproteins. They are under the regulation of neural signals (NEUROTRANSMITTERS) or neuroendocrine signals (HYPOTHALAMIC HORMONES) from the hypothalamus as well as feedback from their targets such as ADRENAL CORTEX HORMONES; ANDROGENS; ESTROGENS.
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.
A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.
Adenoma, Islet Cell
Growth Hormone-Secreting Pituitary Adenoma
ACTH-Secreting Pituitary Adenoma
A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)
Adenomatous Polyposis Coli
A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
Neoplasms, Multiple Primary
Pituitary ACTH Hypersecretion
An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ... Chemokines are produced by activated CD8+ T cells that attract additional inflammatory cells, thereby promoting continued ... The inflammatory infiltrate in oral LP is primarily composed of CD8+ T cells. A potential pathway for CD8+ T cell-mediated ... Oral squamous cell carcinoma (SCC). SCC can present as erythematous or white patches, ulcers, or exophytic masses. The ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ... The relative increase in percentage of CD8+ T cells, caused by a reduction in numbers of CD4+ T cells may be implicated in RAS- ... Mast cells and macrophages are also involved, secreting TNF-α along with the T cells. When early aphthous ulcers are biopsied, ... and the ratio of CD4+ T cells to CD8+ T cells in the peripheral blood of individuals with aphthous stomatitis is decreased. ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ... An odontoblast cell showing odontoblast process (not in proportion - in reality this process is far longer than the body of the ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ... The double-stranded DNA of the virus is incorporated into the cell physiology by infection of the nucleus of a nerve's cell ... "Cell Host & Microbe. 10 (4): 379-89. doi:10.1016/j.chom.2011.08.015. PMC 3201796. PMID 22018238.. ... 1999). "A Novel Role for 3-O-Sulfated Heparan Sulfate in Herpes Simplex Virus 1 Entry". Cell. 99 (1): 13-22. doi:10.1016/S0092- ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ... The involvement of a subset of T cells (Th17) seems to be important. The primary cause is not well known. In fact, no one ... eye inflammation (iritis, uveitis, retinal vasculitis, cells in the vitreous). *genital ulcers (including anal ulcers and spots ... "Humoral and cell mediated immune response to cow's milk proteins in Behçet's disease". Ann. Rheum. Dis. 61 (5): 459-62. doi ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Burning mouth syndrome
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ... or plasma cell gingivitis, which may be accompanied by glossitis and cheilitis. Apart from BMS itself, a full list of ...
Temporomandibular joint dysfunction
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. The role of the ... "Thrombospondin expression in aldosterone-producing adenomas". Hypertension Research. 25 (4): 523-7. doi:10.1291/hypres.25.523. ... Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be ... Armstrong DJ, Hiscott P, Batterbury M, Kaye S (Jun 2002). "Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 ...
Black hairy tongue
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ... shedding of surface epithelial cells). Many people with BHT are heavy smokers. Other possible associated factors are poor ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ... Cytotoxic drugs administered during chemotherapy target cells with fast turnovers such as malignant cells. However, the ... Only the superficial epithelial cells of the epidermis or of the mucosa are lost, and the lesion can reach the depth of the ... The most common type of oral cancer is squamous cell carcinoma. The main causes are long-term smoking and alcohol consumption ( ...
Traditional Serrated Adenoma Serrated crypts, often villous architecture, with cytologic atypia, eosinophilic cells Yes ... Sessile serrated adenoma Similar to hyperplastic with hyperserration, dilated/branched crypt base, prominent mucin cells at ... Spindle cells with concentric arrangements of spindle cells around blood vessels and inflammation rich in eosinophils none ... Tubular Adenoma (Villous, Tubulovillous) Tubular glands with elongated nuclei (at least low-grade atypia) Yes ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ... Histologically, the epithelial cells show signs of intracellular and extracellular edema. ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ... Inflammation (day 1): Virus begins reproducing and infecting cells at the end of the nerve. The healthy cells react to the ... Post-scab (12-14 days): A reddish area may linger at the site of viral infection as the destroyed cells are regenerated. Virus ...
Viable cardiac cells have normal Na+/K+ ion exchange pumps. Thallium binds the K+ pumps and is transported into the cells. ... Tc99m-sestamibi is used to detect parathyroid adenomas. To detect metastases/function of thyroid, the isotopes technetium-99m ... Examples are gallium scans, indium white blood cell scans, iobenguane scan (MIBG) and octreotide scans. The MIBG scan detects ...
"Securin is required for chromosomal stability in human cells". Cell. 105 (4): 445-57. doi:10.1016/S0092-8674(01)00340-3. PMID ... expression in pituitary adenomas". The Journal of Clinical Endocrinology and Metabolism. 84 (2): 761-7. doi:10.1210/jc.84.2.761 ... Ramos-Morales F, Domínguez A, Romero F, Luna R, Multon MC, Pintor-Toro JA, Tortolero M (Jan 2000). "Cell cycle regulated ... Ramos-Morales F, Domínguez A, Romero F, Luna R, Multon MC, Pintor-Toro JA, Tortolero M (Jan 2000). "Cell cycle regulated ...
Multiple endocrine neoplasia type 1
... diffuse hyperplasia or multiple adenomas are more common than solitary adenomas. Pancreatic islet cell tumors are today the ... of islet cell tumors originate from a β-cell, secrete insulin (insulinoma), and can cause fasting hypoglycemia. β-cell tumors ... Multiple adenomas or diffuse islet cell hyperplasia commonly occurs. About 30% of tumors are malignant and have local or ... These genetic changes result in no functional copies of the MEN1 gene in selected cells, allowing the cells to divide with ...
Fedele M, Pierantoni GM, Visone R, Fusco A (September 2006). "Critical role of the HMGA2 gene in pituitary adenomas". Cell ... Dröge P, Davey CA (January 2008). "Do cells let-7 determine stemness?". Cell Stem Cell. 2 (1): 8-9. doi:10.1016/j.stem.2007.12. ... Hammond SM, Sharpless NE (2008). "HMGA2, microRNAs, and stem cell aging". Cell. 135 (6): 1013-1016. doi:10.1016/j.cell.2008.11. ... "Genome-wide analysis of HMGA2 transcription factor binding sites by ChIP on chip in gastric carcinoma cells". Mol. Cell. ...
زونا - ویکیپدیا، دانشنامهٔ آزاد
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ... The virus has never been successfully recovered from human nerve cells by cell culture. The complete sequence of the viral ... the virus replicates in neuronal cell bodies, and virions are shed from the cells and carried down the axons to the area of ... This was finally proved by the first isolation of the virus in cell cultures, by the Nobel laureate Thomas Huckle Weller, in ...
... as well as hepatocellular adenoma. HNF-1 protein is present in clear cell carcinoma of ovary In humans, mutations in HNF1A ... It has been shown to affect intestinal epithelial cell growth and cell lineages differentiation. For instance, HNF1A is an ... "Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in ... "Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages ...
Fecal occult blood
Sickle cell anemia. In the event of a positive fecal occult blood test, the next step in the workup is a form of visualization ... It is able to pick up 80 percent of colorectal cancer and 44 percent for adenoma , 1 centimeter, while gFOBT picks up 13 to 50 ... possibly due to decreased surface glycogen on tumor cells(Lugol). Infrared fluorescent endoscopy and ...
Sertoli cell nodule, also known as Pick's adenoma, a medical disorder. Sports. *Pick, slang term for an interception ...
Mir-16 microRNA precursor family
... "miR-15a and miR-16-1 down-regulation in pituitary adenomas". J Cell Physiol. 204 (1): 280-5. doi:10.1002/jcp.20282. PMID ... Cell. 120 (1): 15-20. doi:10.1016/j.cell.2004.12.035. PMID 15652477. Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh ... proteins implicated in cell proliferation". Biol Cell. 101 (9): 511-24. doi:10.1042/BC20080213. PMID 19250063. Guo CJ, Pan Q, ... functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1". Exp Cell Res. 315 (17): 2941-52 ...
Also known as Hürtle cell tumours. Grossly, oncocytic adenomas are encapsulated, solid nodules with a characteristic brown cut ... Kidney Renal cell carcinoma Hurthle cell Coburn V, Radfar A, Snook D, Mahalingam M (2007). "Cutaneous oncocytoma - a report of ... The cells and the tumor that they compose are often benign but sometimes may be premalignant or malignant. An oncocytoma is an ... An oncocytoma is a tumor made up of oncocytes, epithelial cells characterized by an excessive amount of mitochondria, resulting ...
It is important that other tumors such as pleomorphic adenoma, basal cell adenoma, adenoid cystic carcinoma, and teratoma be ... It has previously been referred to as congenital basal cell adenoma, embryoma, or basaloid adenocarcinoma. It is an extremely ... Seifert, G.; Donath, K. (1997). "The congenital basal cell adenoma of salivary glands. Contribution to the differential ... Tumor cells can be tested by immunohistochemistry which shows: Ductal cells: positive with keratins, CK7 and CK19. Basaloid or ...
The gene has seen in gliomas to suppress cellular differentiation and thus encourage cells to become more stem cell like. Such ... 2005). "Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter". Am. J. ... "PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and glioma". Cancer Cell. 17 (5): 497-509. doi: ... Cell Mol. Biol. 32 (1): 35-43. CiteSeerX 10.1.1.325.6715. doi:10.1165/rcmb.2003-0422OC. PMID 15361364. Strausberg RL, Feingold ...
Cell Stem Cell. 1 (6): 685-697. doi:10.1016/j.stem.2007.10.020. PMID 18371409. Liang Y, Diehn M, Watson N, Bollen AW, Aldape KD ... ID4 is not found in normal epitheliums nor adenomas of colorectal cancer. Hypermethylation of ID4 causes silencing of the gene ... diffuse B Cell lymphomas and lymphoid cell lines due to hypermethylation. In brain tumours, more specifically oligodendroglial ... In B-Cell (B lymphocyte) acute lymphoblastic leukaemia (B-ALL), ID4 is overexpressed due to being located in close proximity to ...
F9 embryonal carcinoma cells are similar to the P19 cells shown in Figure 1 and normally have cell-to-cell adhesion mediated by ... Summary: Associated Cancers: colorectal and ovarian cancer; pilomatrixoma; medulloblastoma; pleomorphic adenomas; malignant ... A tumor cell line with defective δ-catenin, low levels of E-cadherin and poor cell-to-cell adhesion could be restored to normal ... providing the cell with a means of stable cell adhesion. However, decreases in this adhesion ability of the cell has been ...
... excess secretion from the acidophil cells) caused acromegaly, then an excess of basophil cells must be involved in another ... Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome, when excluding Cushing's syndrome from ... Given this conviction, and his knowledge of the three anterior pituitary cell types, Cushing hypothesized that if acidophil ... The first-line treatment of Cushing's disease is surgical resection of ACTH-secreting pituitary adenoma; this surgery involves ...
... nephrogenic adenomas, ovarian cancer cells, bladder, prostate, and endometrial carcinomas. The mechanism of switching on the ... regulation of metanephric nephron tubule epithelial cell differentiation. • cell differentiation. • mesonephric tubule ... positive regulation of metanephric DCT cell differentiation. • negative regulation of mesenchymal cell apoptotic process ... pancreatic islet cells and lymphoid cells. PAX8 and other transcription factors play a role in binding to DNA and regulating ...
Anaplastic cells have lost total control of their normal functions and many have deteriorated cell structures. Anaplastic cells ... Pituitary adenomas ("pituitary tumours") are sometimes incorrectly referred to as a brain tumours. This is perhaps ... Necrotic cells send the wrong chemical signals which prevent phagocytes from disposing of the dead cells, leading to a buildup ... Glial cells such as Schwann cells in the periphery or, within the cord itself, oligodendrocytes, wrap themselves around the ...
BaP was shown to cause genetic damage in lung cells that was identical to the damage observed in the DNA of most malignant lung ... Sinha R, Kulldorff M, Gunter MJ, Strickland P, Rothman N.Dietary Benzo[a]Pyrene Intake and Risk of Colorectal Adenoma Cancer ... BaP has an effect on the number of white blood cells, inhibiting some of them from differentiating into macrophages, the body's ... This gene is a transcription factor that regulates the cell cycle and hence functions as a tumor suppressor. By inducing G ( ...
... distributes readily in high concentrations into immune cells, has antimicrobial and natural killer cell activities, ... and E and the risk of colorectal adenoma: a meta-analysis of observational studies". European Journal of Cancer Prevention. 22 ... Cell. 132 (6): 1039-48. doi:10.1016/j.cell.2008.01.042. PMID 18358815. Lay summary - Science Daily (March 21, 2008).. ... Plant and Cell Physiology. 45 (9): 1271-1279. doi:10.1093/pcp/pch152. PMID 15509850.. ...
Targeting double-stranded breaks increases the probability that cells will undergo cell death. Cancer cells are generally less ... Fractionation allows normal cells time to recover, while tumor cells are generally less efficient in repair between fractions. ... Single-strand DNA damage is then passed on through cell division; damage to the cancer cells' DNA accumulates, causing them to ... Fractionation also allows tumor cells that were in a relatively radio-resistant phase of the cell cycle during one treatment to ...
Due to its mode of beta decay, iodine-131 is notable for causing mutation and death in cells that it penetrates, and other ... For example, children treated with moderate dose of 131I for thyroid adenomas had a detectable increase in thyroid cancer, but ... This occurs because when the radioactive iodine destroys the thyroid cells, they can release thyroid hormone into the blood ... Use of the 131I as iodide salt exploits the mechanism of absorption of iodine by the normal cells of the thyroid gland. ...
The fat cells take up glucose through special glucose transporters (GLUT4), whose numbers in the cell wall are increased as a ... over-production of parathyroid hormone by a parathyroid adenoma resulting in the typically features of hyperparathyroidism, ... The sensors for the second are the parafollicular cells in the thyroid gland. The parathyroid chief cells secrete parathyroid ... Instead of measuring it directly in the blood flowing past the juxtaglomerular cells, these cells respond to the sodium ...
ಮೆದುಳಿನ ಕ್ಯಾನ್ಸರ್ ಗೆಡ್ದೆ(ಊತ) - ವಿಕಿಪೀಡಿಯ
Echevarría ME, Fangusaro J, Goldman S (2008). "Pediatric central nervous system germ cell tumors: a review". Oncologist. 13 (6 ...
... a prolactin-secreting pituitary adenoma. ... A lactotropic cell (also known as prolactin cell, epsilon ... Prolactin cells are acidophilic by hematoxylin & eosin stains and comprise about 20% of all cells in the anterior pituitary ... This cell biology article is a stub. You can help Wikipedia by expanding it.. *v ... If these cells undergo neoplastic transformation, they will give rise to a prolactinoma, ...
Histologically, it forms clusters of goblet cells containing mucin with a minor admixture of Paneth cells and endocrine cells. ... Adenomas/. adenocarcinomas. (8140-8429). Gastrointestinal. *tract: Linitis plastica. *Familial adenomatous polyposis. *pancreas ... Goblet cell carcinoid. Main article: Goblet cell carcinoid. This is considered to be a hybrid between an exocrine and ... Carcinoid (also carcinoid tumor) is a slow-growing type of neuroendocrine tumor originating in the cells of the ...
神經母細胞瘤 - 维基百科，自由的百科
鱗狀細胞癌（英语：Squamous-cell thyroid carcinoma）. *良性 *甲狀腺腺瘤（英语：Thyroid adenoma） ... 甲狀腺癌（惡性）：上皮細胞（英语：Thyroid epithelial cell）癌 *乳突性（英语：Papillary thyroid cancer） ... 濾泡性（英语：Follicular thyroid cancer）/何氏細胞（英语：Hurthle cell）（
Adenoma sebaceum. *Metastatic carcinoma. *Giant-cell tumor of the tendon sheath. *Glomus tumor ...
Haboubi NY, Ali HH, Whitwell HL, Ackrill P (1988). "Role of endothelial cell injury in the spectrum of azathioprine-induced ... hepatocellular adenoma, and hepatocarcinoma ...
The differential diagnosis of a renal tumor in a young patient with hypertension includes Juxtaglomerular cell tumor, Wilms' ... Molecular basics of aldosterone and cortisol synthesis in normal adrenals and adrenocortical adenomas]". Endokrynologia Polska ... Méndez GP, Klock C, Nosé V (December 2008). "Juxtaglomerular Cell Tumor of the Kidney: Case Report and Differential Diagnosis ... tumor, and renal cell carcinoma, all of which may produce renin. ...
The most common medications affect mainly the fast-dividing cells of the body, such as blood cells and the cells lining the ... M - mitosis; where the cell divides to produce two daughter cells that continue the cell cycle. ... cells that produce white and red blood cells) are destroyed, meaning allogenic or autologous bone marrow cell transplants are ... Drugs used in chemotherapy can induce cell stress, which can kill a cancer cell; however, under certain conditions, cells ...
Inflammatory breast cancer
It is characterised by the presence of cancer cells in the subdermal lymphatics on skin biopsy. Consequently, IBC is always ... caveolin-1 and -2 are overexpressed and may contribute to tumour cell motility ... 2 in cell lines and in human samples of inflammatory breast cancer". Breast Cancer Research and Treatment. 95 (3): 219-28. doi: ... Nipple adenoma. Related subjects. *Main article. *Classification. *Risk factors (Alcohol, Hereditary breast-ovarian cancer ...
Fitosterol - Wikipedija, prosta enciklopedija
Verjetnost za razvoj raka iz adenoma je 30:1. Žolčne kisline so dobro znani promotorji tumorjev. Izsledki določenih študij ... 3.β-Sitosterol enhances tamoxifen effectiveness on breast cancer cells by affecting ceramide metabolism. Atif B. Awad, ...
... mononuclear cell leukemia, hepatocellular adenomas and renal tubule cell adenomas. The Campaign for Safe Cosmetics has also ... This chamber is lined with cells that secrete catalases and peroxidases. When the contents of the reservoir are forced into the ... including thyroid follicular cell hyperplasias, anisokaryosis (variation in nuclei sizes), ...
Single-photon emission computed tomography
White cell scan. indium-111 & technetium-99m. 171 & 245. 67 hours. in vitro labelled leucocytes. 18. 360. 60. 64 x 64. 30 ... where the technique is useful in locating ectopic parathyroid adenomas which may not be in their usual locations in the thyroid ...
Squamous-cell carcinoma of the vagina. *Botryoid rhabdomyosarcoma. *Clear cell adenocarcinoma of the vagina ... Pleomorphic adenoma. *Mixed Müllerian tumor. *Mesoblastic nephroma. *Wilms' tumor. *Malignant rhabdoid tumour ...
Schumacker PT (September 2006). "Reactive oxygen species in cancer cells: live by the sword, die by the sword". Cancer Cell. 10 ... antioxidant supplements for primary and secondary prevention of colorectal adenoma". Alimentary Pharmacology & Therapeutics. 24 ... Rhee SG (June 2006). "Cell signaling. H2O2, a necessary evil for cell signaling". Science. 312 (5782): 1882-3. doi:10.1126/ ... Many polyphenols may have non-antioxidant roles in minute concentrations that affect cell-to-cell signaling, receptor ...
Non-hematopoietic mesenchymal cells ⇨ sarcoma. *Hematopoietic cells *Bone marrow-derived cells that normally mature in the ... Adenomas/. adenocarcinomas. (8140-8429). Gastrointestinal. *tract: Linitis plastica. *Familial adenomatous polyposis. *pancreas ... Composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm.. Small cell carcinoma. Cells ... Certain combinations of mutations in the given progenitor cell ultimately result in that cell (also called a cancer stem cell) ...
BaP was shown to cause genetic damage in lung cells that was identical to the damage observed in the DNA of most malignant lung ... Sinha R, Kulldorff M, Gunter MJ, Strickland P, Rothman N.Dietary Benzo[a]Pyrene Intake and Risk of Colorectal Adenoma Cancer ... BaP has an effect on the number of white blood cells, inhibiting some of them from differentiating into macrophages, the body's ... A 2005 NCI study found an increased risk of colorectal adenomas was associated with BaP intake, and more strongly with BaP ...
In order for a normal cell to transform into a cancer cell, the genes that regulate cell growth and differentiation must be ... "Folic acid for the prevention of colorectal adenomas: a randomized clinical trial". JAMA. 297 (21): 2351-59. doi:10.1001/jama. ... Germ cell tumor: Cancers derived from pluripotent cells, most often presenting in the testicle or the ovary (seminoma and ... "Cell. 126 (3): 477-87. doi:10.1016/j.cell.2006.05.051. PMC 2593932. PMID 16901782.. ...
Mir-181 microRNA precursor
... "miR-181a is an intrinsic modulator of T cell sensitivity and selection". Cell. 129 (1): 147-61. doi:10.1016/j.cell.2007.03.008 ... Mir-210 has been suggested as a useful biomarker to distinguish adrenocortical carcinoma from adrenocortical adenoma. in ... miR-181a is essential for the survival of Purkinje cells and its absence leads to a slow degeneration of these cells. It has ... The expression of miR-181a correlates with a greater sensitivity of immature T cells in T cells, suggesting that miR-181a acts ...
B-flow is a mode that digitally highlights moving reflectors (mainly red blood cells) while suppressing the signals from the ... A similar localization procedure with methylene blue, can be done to locate parathyroid adenomas at surgery. ... Specifically, sound is reflected anywhere where there are acoustic impedance changes in the body: e.g. blood cells in blood ... The strength of the echo determines the brightness setting for that cell (white for a strong echo, black for a weak echo, and ...
Hyperinsulinism Due to Islet-cell Adenoma | The BMJ
Liver Cell Adenoma or Hepatocellular Carcinoma?
'Hyaline cells' in pleomorphic adenoma of salivary gland...
... plasmacytoid cells). Hyaline cells were found in 38 percent of the minor salivary gland cases and 21 perc … ... and seventy-two cases of pleomorphic adenoma of major salivary gland origin were examined for the presence of hyaline cells ( ... Fifty-two cases of pleomorphic adenoma of minor salivary gland origin ... "Hyaline cells" in pleomorphic adenoma of salivary gland origin Oral Surg Oral Med Oral Pathol. 1981 Nov;52(5):506-12. doi: ...
DNA ploidy and proliferating cell nuclear antigen in colonic adenomas and adenocarcinomas | SpringerLink
To investigate the colonic adenoma-adenocarcinoma progression sequence, DNA ploidy analysis was performed on hyperplastic ... colonic polyps adenomas adenocarcinomas DNA ploidy proliferating cell nuclear antigen This is a preview of subscription content ... In hyperplastic polyps to villous adenomas, all cases were diploid except one aneuploid villous adenoma. In three adenomas, ... Tomita T:p53 and proliferating cell nuclear antigen in islet cell tumors and carcinoids (submitted)Google Scholar ...
Basal cell adenoma - Wikipedia
Hürthle cell adenoma - Wikipedia
Hürthle cell adenoma is the benign analogue of Hürthle cell carcinoma. This adenoma is extremely rare; when it occurs, it ... 1998), "Unilateral lobectomy for Hürthle cell adenoma", Am Surg, 64 (8): 729-732, PMID 9697901. "Hurthle Cell Adenoma". www. ... "Appearance of Hürthle cell carcinoma soon after surgical extirpation of Hürthle cell adenoma and follicular adenoma of the ... Hürthle cell adenoma is a rare benign tumor, typically seen in women between the ages of 70 and 80 years old. This adenoma is ...
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. - PubMed - NCBI
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.. van Es JH1, ... The inhibitor also induced goblet cell differentiation in adenomas in mice carrying a mutation of the Apc tumour suppressor ... Thus, maintenance of undifferentiated, proliferative cells in crypts and adenomas requires the concerted activation of the ... Here we show a rapid, massive conversion of proliferative crypt cells into post-mitotic goblet cells after conditional removal ...
Hepato-biliary Pathology: Liver: Liver cell adenoma | Podcasts | Naked Scientists
Human prolactin secreting adenoma cells maintained on extracellular matrix.
... corneal endothelial cells is associated with the adoption of morphological properties that are not expressed when the cells are ... In vitro maintenance of human prolactin secreting adenoma cells on a extracellular matrix (ECM) produced by bovine ... Moreover, prolactin production from cells on ECM is frequently stable for several weeks. Both tumor cells and normal cells are ... Adenoma / metabolism*. Animals. Cattle. Cells, Cultured. Cornea / cytology. Humans. Neoplasms, Experimental / metabolism. ...
THE BIOSYNTHESIS OF INSULIN AND A PROBABLE PRECURSOR OF INSULIN BY A HUMAN ISLET CELL ADENOMA | PNAS
THE BIOSYNTHESIS OF INSULIN AND A PROBABLE PRECURSOR OF INSULIN BY A HUMAN ISLET CELL ADENOMA. Donald F. Steiner and Philip E. ... THE BIOSYNTHESIS OF INSULIN AND A PROBABLE PRECURSOR OF INSULIN BY A HUMAN ISLET CELL ADENOMA ... THE BIOSYNTHESIS OF INSULIN AND A PROBABLE PRECURSOR OF INSULIN BY A HUMAN ISLET CELL ADENOMA ... THE BIOSYNTHESIS OF INSULIN AND A PROBABLE PRECURSOR OF INSULIN BY A HUMAN ISLET CELL ADENOMA ...
Hurthle cell adenoma | definition of Hurthle cell adenoma by Medical dictionary
What is Hurthle cell adenoma? Meaning of Hurthle cell adenoma medical term. What does Hurthle cell adenoma mean? ... Looking for online definition of Hurthle cell adenoma in the Medical Dictionary? Hurthle cell adenoma explanation free. ... nonsecreting adenoma (nonsecretory adenoma) endocrine-inactive adenoma.. null-cell adenoma a pituitary adenoma whose cells give ... Hürthle cell adenoma a benign hürthle cell tumor.. hyperfunctional adenoma (hyperfunctioning adenoma) endocrine-active adenoma. ...
Leydig cell adenoma | definition of Leydig cell adenoma by Medical dictionary
What is Leydig cell adenoma? Meaning of Leydig cell adenoma medical term. What does Leydig cell adenoma mean? ... Looking for online definition of Leydig cell adenoma in the Medical Dictionary? Leydig cell adenoma explanation free. ... Leydig cell adenoma. Leydig cell adenoma. A benign circumscribed nodule of autonomously hyperfunctioning hyperplastic Leydig ... Synonym(s): interstitial cell tumor of testis. Leydig cells - cells between the seminiferous tubules of the testis that secrete ...
Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas
Synchronous unilateral basal cell adenoma of the parotid gland: A case report.
25202417 - Synchronous unilateral basal cell adenoma of the parotid gland: a case report.. 15083867 - Systematic search and ... A total parotidectomy was performed and basal cell adenomas (BCAs) were identified by histopathological examination. At the 6- ... Previous Document: Hsa-microRNA-101 suppresses migration and invasion by targeting Rac1 in thyroid cancer cells.. Next Document ...
Butyrate- but not TGFβ 1 -induced apoptosis of colorectal adenoma cells is associated with increased expression of the...
The effect of different TP53 mutations on the chromosomal stability of a human colonic adenoma derived cell line with...
We examined the effect of loss of wild type TP53 activity on the chromosomal stability of a human colonic adenoma derived cell ... The effect of different TP53 mutations on the chromosomal stability of a human colonic adenoma derived cell line with ... It was found that the proportion of cells with more than 4% aberrations was significantly greater in the AA/273p53/B cell line ... cells were exposed to 5 Gy gamma radiation. Regardless of TP53 status, cells with radiation induced chromosomal damage were ...
Usefulness of markers of cell proliferation in the management of pituitary adenomas | Clinical Science
Usefulness of markers of cell proliferation in the management of pituitary adenomas. Marco LOSA, Alberto FRANZIN, Pietro ... Usefulness of markers of cell proliferation in the management of pituitary adenomas ... Usefulness of markers of cell proliferation in the management of pituitary adenomas ... Usefulness of markers of cell proliferation in the management of pituitary adenomas ...
Atypical hurthle cell adenoma: be aware | ECE2019
Atypical hurthle cell adenoma: be aware. Antonis Polymeris, Christina Kogia, Maria Drakou, Dimitrios Lilis & Dimitrios ... Introduction: Among all thyroid nodules 3 to 10% are Hürthle cell (HC) neoplasms classified as either HC adenomas or carcinomas ... Conclusion: Even though histologically characterized Hürthle cell adenomas could be reassuring, long term follow up by a ... The histological examination revealed an atypical Hürthle cell adenoma. Consequently, he has been receiving levothyroxine ...
Expression of cell proliferation markers in pituitary adenomas - correlation and clinical relevance of MIB-1 and anti...
To improve understanding of their different biological behaviour, tumor cell... ... Pituitary adenomas represent an inhomogenous tumor entity in terms of growth rate, invasiveness and recurrence. ... Silent ACTH-cell and PRL-producing adenomas had the highest, null-cell adenomas and gonadotropinomas the lowest proliferation ... We analyzed tumor cell proliferation rates using MIB-1 and Topo-IIα antibodies on samples of 260 primary pituitary adenomas. We ...
Cell Proliferation and Apoptotic Indices Predict Adenoma Regression in a Placebo-Controlled Trial of Celecoxib in Familial...
Cell Proliferation and Apoptotic Indices Predict Adenoma Regression in a Placebo-Controlled Trial of Celecoxib in Familial ... Cell Proliferation and Apoptotic Indices Predict Adenoma Regression in a Placebo-Controlled Trial of Celecoxib in Familial ... Cell Proliferation and Apoptotic Indices Predict Adenoma Regression in a Placebo-Controlled Trial of Celecoxib in Familial ... Cell Proliferation and Apoptotic Indices Predict Adenoma Regression in a Placebo-Controlled Trial of Celecoxib in Familial ...
Cell Proliferation and Apoptotic Indices Predict Adenoma Regression in a Placebo-Controlled Trial of Celecoxib in Familial...
Cell Proliferation and Apoptotic Indices Predict Adenoma Regression in a Placebo-Controlled Trial of Celecoxib in Familial ... Specifically, colorectal adenomas have increased numbers of proliferating cells at or near the luminal surface and more ... Cell Proliferation and Apoptotic Indices Predict Adenoma Regression in a Placebo-Controlled Trial of Celecoxib in Familial ... Cell Proliferation and Apoptotic Indices Predict Adenoma Regression in a Placebo-Controlled Trial of Celecoxib in Familial ...
Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid...
Metanephric adenoma is a benign renal neoplasm that overlaps in morphology with the solid variant of papillary renal cell ... We analyzed 37 tumors originally diagnosed as metanephric adenomas (2 of which we reclassified as papillary renal cell ... Citric acid, anhydrous, cell culture tested, plant cell culture tested C6H8O7 ... Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid ...
Altered chemokine production and accumulation of regulatory T cells in intestinal adenomas of APC(Min/+) mice
However, whether Th1 cells and Tregs are already present at the adenoma stage is not known. In this study, the APC(Min/+) mouse ... Altered chemokine production and accumulation of regulatory T cells in intestinal adenomas of APC(Min/+) mice. Akeus, Paulina ... Despite high Treg numbers, the function of conventional T cells present in the APC(Min/+) adenomas was not different from those ... T cell infiltration into colorectal adenocarcinomas, particularly T helper 1 (Th1) type T cells as well as increased regulatory ...
Histogenesis of human colorectal adenomas and hyperplastic polyps: the role of cell proliferation and crypt fission | Gut
Proliferating cell nuclear antigen as a marker of cell kinetics in aberrant crypt foci, hyperplastic polyps, adenomas, and ... has suggested that adenomas grow by a "top-down morphogenesis," taking origin from mutant stem cells on the surface of the ... Eleven cases of adenomas (six cases of tubular adenomas (one with mild dysplasia and five with moderate dysplasia), four cases ... Expansion of the proliferative compartment was demonstrated in crypts from adenomas, consistent with deregulation of cell cycle ...
salivary basal cell adenoma with cribriform pattern - Humpath.com - Human pathology
Definition: Subtype of salivary basal cell adenoma. Differential diagnosis adenoid cystic carcinoma (AdCC) Cribriform type of ... Home , F. Pathology by regions , Head and neck , Head , Mouth - Oral cavity , Salivary glands , salivary basal cell adenoma ... Basal cell adenoma of salivary glands with a focal cribriform pattern: clinicopathologic and immunohistochemical study of 19 ... Cribriform type of salivary basal cell adenoma (cBCA) is relatively rare and problematic in distinction from adenoid cystic ...
Simultaneous renal cell carcinoma, adrenal adenoma, and carcinoma of the esophagus: report of a case | The Journal of the...
Simultaneous renal cell carcinoma, adrenal adenoma, and carcinoma of the esophagus: report of a case. The Journal of the ... Simultaneous renal cell carcinoma, adrenal adenoma, and carcinoma of the esophagus: report of a case ... Simultaneous renal cell carcinoma, adrenal adenoma, and carcinoma of the esophagus: report of a case ... Chack J, Finkelstein L, Marks B. Simultaneous renal cell carcinoma, adrenal adenoma, and carcinoma of the esophagus: report of ...
Abstract LB-271: Inulin inhibits free radical species in HCT 116 adenoma carcinoma and normal human HK (keratinocyte) cell line...
30% Inulin enhanced cell death of morphologically changed cells in the presence of DC ,150μM, with complete cell death ... Abstract LB-271: Inulin inhibits free radical species in HCT 116 adenoma carcinoma and normal human HK (keratinocyte) cell line ... Abstract LB-271: Inulin inhibits free radical species in HCT 116 adenoma carcinoma and normal human HK (keratinocyte) cell line ... Abstract LB-271: Inulin inhibits free radical species in HCT 116 adenoma carcinoma and normal human HK (keratinocyte) cell line ...
Abstract 4891: The short isoform of stem-cell-marker DCLK1(DCLK1-S) is strongly up-regulated during adenoma-carcinoma sequence...
Colon cancer cells either expressed S (HCT-116) or both S and L forms (HT-29, DLD1). HEK293 cells were used as a model of non- ... The short isoform of stem-cell-marker DCLK1(DCLK1-S) is strongly up-regulated during adenoma-carcinoma sequence of coloncancer ... Abstract 4891: The short isoform of stem-cell-marker DCLK1(DCLK1-S) is strongly up-regulated during adenoma-carcinoma sequence ... Abstract 4891: The short isoform of stem-cell-marker DCLK1(DCLK1-S) is strongly up-regulated during adenoma-carcinoma sequence ...
Telomere shortening of epithelial cells characterises the adenoma-carcinoma transition of human colorectal cancer | Gut
A) Adenoma-carcinoma transition: the adenoma (A) on the right shows typical epithelial cells in a single cell layer whereas HGD ... A) DAPI stained section of adenoma epithelial cell nuclei. (B) Adenoma epithelial cell nuclei stained with a telomere specific ... In contrast with epithelial cells, cells from connective tissue had a similar TFI in adenoma and high grade dysplasia of ... whereas the adenoma (A) at the bottom shows polarised epithelial cells and goblet cells. CT, connective tissue (magnification ...
TumorsCarcinomaProliferationPleomorphicCarcinomasColonicCorticotrophNeoplasmsSalivary glandsAbstractType of pituitaryEpithelial cellsPathologyIntestinalThyroidMucosaRecurrenceMalignantSubtypeHepatocellular adenomaApoptosisDevelopment of pituitary adenomasParathyroidImmunohistochemistryLactotrophHuman colorectalTumorigenesisParotidHistologicallyBenign tumorGeneDifferentiationClinicalAdrenocorticotropic hormone-secretiPremalignantAdenocarcinomaNull-cell adenomaTherapeutic agent for patients with prolactinomasSecretionFollicularBasal cell adenomasLiver cell adenomasFindingsAdopted a pituitaryTumor cellHistopathologyInvasiveOncocytomaColorectal cancerSporadicClassificationSparsely granulatedVillousSignificantlyFamilial
- Leydig cell adenoma - small benign tumors of the testis that often produce testosterone, causing endocrine symptoms. (thefreedictionary.com)
- Only MIB-1 was significantly higher in invasive as compared to non-invasive adenomas, in tumors ≤3 cm in diameter, and in the age-group 21-40. (springer.com)
- We analyzed 37 tumors originally diagnosed as metanephric adenomas (2 of which we reclassified as papillary renal cell carcinomas), 13 solid variant papillary renal cell carcinomas, and 20 epithelial-predominant nephroblastomas using a combination of immunohistochemistry and fluorescence in situ hybridization (FISH) assessing for trisomy of chromosomes 7 and 17 and loss of Y. Immunohistochemical staining was performed for CK7, AMACR, WT1, and CD57. (sigmaaldrich.com)
- Most of the tumors originally diagnosed as metanephric adenomas (31/37) showed the expected staining pattern of metanephric adenoma (CK7-, AMACR-, WT1+, and CD57+). (sigmaaldrich.com)
- Of the six tumors with discordant immunophenotype, two tumors were reclassified as papillary renal cell carcinoma after cytogenetic workup. (sigmaaldrich.com)
- We now know that colonic tumors increasingly express progastrins (PG) as they progress through hyperproliferative (Hp) / adenoma (Ad) / adenocarcinoma (AdCA) sequence. (aacrjournals.org)
- Our studies so far strongly suggest that DCLK1 expression is required for maintaining proliferation of colon cancer cells and that while normal colonic cells/non-transformed HEK293 cells mainly express the L-isoform, colonic tumors increasingly express the S-isoform, suggesting a differential role of these isoforms in the normal vs cancer cell biology. (aacrjournals.org)
- FPCK/NO cells formed tumors, whereas vehicle-treated cells (FPCK/NaOH) did not. (eurekamag.com)
- These tumors include the pituicytoma , the spindle cell oncocytoma , the granular cell tumor of the neurohypophysis , and the sellar ependymoma 2) . (operativeneurosurgery.com)
- Pituitary adenomas are tumors that occur in the pituitary gland. (sinoprot.com)
- Immunization of the Apc(Min/+) mice with a HSP105-pulsed BM-DC vaccine at 6, 8, and 10 weeks of age significantly reduced the number of small-intestinal polyps accompanied by infiltration of both CD4(+) and CD8(+) T cells in the tumors. (docphin.com)
- Prolactinomas, prolactin-secreting pituitary adenomas, are the most frequently found functional pituitary tumors in humans. (biomedcentral.com)
- American Journal of Roentgenology 189 (5): 254-261, 2007 de Araujo VC: Basal cell adenoma, In: Barnes L, Everson JW, Reichart P, Sidransky D, editors: World Health Organization classification of tumors. (haomsjournal.org)
- The genesis of pituitary tumors is still mainly unknown, but the actual model supposes that genetic alterations represent the initializing event that transforms pituitary cells, and that hypothalamic hormones and other local growth factors may play an important role in promoting the growth of already transformed cells. (biomedcentral.com)
- Adenomas were classified according to the genotype of the tumors, such as the finding of mutations in HNF1A , in CTNNB1 -activating β-catenin and/or in the interleukin-6 transducer of signal ( IL6ST ) activating gp130 ( 4 - 8 ). (diabetesjournals.org)
- However, the mechanism by which bromocriptine decreases elevated serum levels of prolactin or growth hormone and shrinks tumors by diminishing tumor cell size is not clear. (edu.au)
- Ganglion cell tumors in intersellar region are rare. (journalcra.com)
- Familial isolated pituitary adenoma is inherited in an autosomal dominant manner and accounted for approximately 2-3% of pituitary tumors in some series. (scielo.br)
- The vast majority of pituitary adenomas, however, arise sporadically, and inherited germline mutations in different genes are few in number, accounting for approximately 5% of all pituitary tumors (6). (scielo.br)
- Large pituitary tumors can put pressure on normal pituitary cells. (providence.org)
- The effects of human recombinant basic fibroblastic growth factor (bFGF) on the secretion and/or proliferation of 26 human anterior pituitary adenomas secreting PRL alone (6 tumors), PRL and GH (18 tumors), or GH alone (2 tumors) were examined. (elsevier.com)
- The purpose of this study is to determine a safe number of these cells to infuse and to see if these tumor fighting cells (anti-mesothelin cells) cause metastatic cancer tumors to shrink. (clinicaltrials.gov)
- Liver Cell Adenoma or Hepatocellular Carcinoma? (medindia.net)
- Typically such a mass is removed because it is not easy to predict whether it will transform into the malignant counterpart, a subtype of follicular thyroid cancer called a Hürthle cell carcinoma. (wikipedia.org)
- Hürthle cell adenoma is the benign analogue of Hürthle cell carcinoma. (wikipedia.org)
- However, often doctors suggest this treatment to patients with Hürthle cell adenoma and Hürthle cell carcinoma because some Hürthle cells will respond and it will kill remaining tissue. (wikipedia.org)
- Gjorceva, DP (2015), "Appearance of Hürthle cell carcinoma soon after surgical extirpation of Hürthle cell adenoma and follicular adenoma of the thyroid gland", Radiol Oncol, 49 (1): 26-31, doi:10.2478/raon-2014-0047, PMC 4362603, PMID 25810698. (wikipedia.org)
- Hürthle cell carcinoma could also lead to distant metastases and its decreased ability to uptake radioiodine worsens the prognosis. (endocrine-abstracts.org)
- Biopsy was taken from the latter as well as from transbronchial needle aspiration and both displayed neoplastic infiltration with morphological and immunohistochemical characteristics of Hürthle cell thyroid carcinoma. (endocrine-abstracts.org)
- Conclusion: Even though histologically characterized Hürthle cell adenomas could be reassuring, long term follow up by a specialized Endocrinologist is essential in the context of occasional recurrence or metastases, leading in a final diagnosis of a Hürthle cell carcinoma as in our case. (endocrine-abstracts.org)
- Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid variant papillary renal cell carcinoma and epithelial-predominant nephroblastoma. (sigmaaldrich.com)
- Metanephric adenoma is a benign renal neoplasm that overlaps in morphology with the solid variant of papillary renal cell carcinoma and epithelial-predominant nephroblastoma. (sigmaaldrich.com)
- Method: Human colorectal adenomas, hyperplastic polyps, and normal colorectal mucosae (patients with familial adenomatous polyposis and hereditary non-polyposis colorectal carcinoma were excluded) were obtained during colonoscopy and microdissected into individual crypts. (bmj.com)
- Cribriform type of salivary basal cell adenoma (cBCA) is relatively rare and problematic in distinction from adenoid cystic carcinoma (AdCC). (humpath.com)
- Abstract 4891: The short isoform of stem-cell-marker DCLK1(DCLK1-S) is strongly up-regulated during adenoma-carcinoma sequence of coloncancer disease: Role of autocrine/endocrine progastrin. (aacrjournals.org)
- The short isoform of stem-cell-marker DCLK1(DCLK1-S) is strongly up-regulated during adenoma-carcinoma sequence of coloncancer disease: Role of autocrine/endocrine progastrin. (aacrjournals.org)
- To test this hypothesis, the telomere length of colorectal epithelial cells and cells from connective tissue was determined at the adenoma-carcinoma transition at the cellular level by quantitative fluorescence in situ hybridisation. (bmj.com)
- Our study showed that the telomere fluorescence intensity of epithelial cells was significantly weaker at the earliest morphologically definable stage of carcinoma-high grade dysplasia with minimal invasive growth-compared with the surrounding adenoma. (bmj.com)
- In contrast, cells from connective tissue had a similar telomere signal intensity at the carcinoma stage compared with the adenoma, and in turn cells from connective tissue had overall significantly stronger telomere fluorescence signals compared with epithelial cells. (bmj.com)
- These results demonstrate that short telomeres of epithelial cells characterise the adenoma-carcinoma transition during human colorectal carcinogenesis, suggesting that carcinomas arise from cells with critical short telomeres within the adenoma. (bmj.com)
- Since the adenoma-carcinoma transition in colorectal cancer is characterised by an increase in chromosomal instability and anaphase bridges, our data support the hypothesis that short telomeres initiate colorectal cancer by induction of chromosomal instability. (bmj.com)
- Colorectal cancer is one of the most common malignancies worldwide and is characterised by sequential morphological changes of the colonic mucosa spanning the adenoma-carcinoma transition coupled with increasing genetic alterations. (bmj.com)
- 1 Morphologically, the adenoma-carcinoma transition is characterised by the emergence of high grade dysplastic epithelial cells clonally expanding within the surrounding adenomatous polyp. (bmj.com)
- 2 CIN sharply increases at the adenoma-carcinoma transition. (bmj.com)
- 5- 14 Mutations in several genes governing mitotic 15 and cell cycle checkpoints (for example, p53) 16 have been linked to the onset of CIN at the adenoma-carcinoma transition but the mechanisms leading to the CIN phenotype have yet to be evaluated. (bmj.com)
- In the Research Article " Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells ," part of the P value in Fig. 1A was inadvertently deleted during processing. (sciencemag.org)
- Squamous cell carcinoma (SCC) as the malignant component of carcinoma ex pleomorphic adenoma (CXPA) occurring in upper lip is rare. (biomedcentral.com)
- Carcinoma ex pleomorphic adenoma (CXPA), described as a rare malignant epithelial tumor arising from a pre-existing pleomorphic adenoma (PA), accounts for approximately 12% of all salivary gland malignancies and 6.2% of all PAs [ 1 ]. (biomedcentral.com)
- Histopathologically, the malignant component is most frequently a poorly differentiated adenocarcinoma or undifferentiated carcinoma, but uncommonly is a squamous cell carcinoma (SCC) [ 1 ]. (biomedcentral.com)
- This analysis did not demonstrate an expression of PAX8, CD10 or vimentin, which excluded the possibility of renal clear cell carcinoma metastasis. (exp-oncology.com.ua)
- The differential diagnosis of WCCA includes metastatic renal cell carcinoma in the parathyroid gland and paraganglioma. (exp-oncology.com.ua)
- Ectopic expression of caveolin-1 in NIH3T3 cells and T24 human bladder carcinoma cells sensitizes cells to staurosporine-induced apoptosis [ 17 ]. (biomedcentral.com)
- Non-invasive basal cell or squamous cell skin carcinoma. (centerwatch.com)
- Several groups have studied adenomas as the intermediate step of gastric carcinoma development [ 2 , 8 ]. (medsci.org)
- 3. The results reported in the literature show that adrenocorticotropic hormone-secreting tumours seem to be characterized by a higher proliferation index than the other types of pituitary adenomas, despite their usually small tumour size. (clinsci.org)
- 5. From a clinical point of view, however, the more promising utilization of the proliferation index seems to be in predicting the potential of recurrence of the tumour, thus allowing a more rational approach to follow-up and further treatment of patients with pituitary adenomas. (clinsci.org)
- To improve understanding of their different biological behaviour, tumor cell proliferation markers are applied. (springer.com)
- The aim of this study was to assess proliferation rates overall and in clinico-pathological subgroups using MIB-1 and the recently introduced cell proliferation marker anti-topoisomerase-IIα (Topo-IIα). (springer.com)
- We analyzed tumor cell proliferation rates using MIB-1 and Topo-IIα antibodies on samples of 260 primary pituitary adenomas. (springer.com)
- Silent ACTH-cell and PRL-producing adenomas had the highest, null-cell adenomas and gonadotropinomas the lowest proliferation values, respectively. (springer.com)
- To address the mechanism of polyp regression, we determined whether celecoxib can modulate cell proliferation, apoptosis, and prostaglandin E 2 (PGE 2 ) levels in colorectal epithelia from FAP trial participants and whether such alterations correlate with observed reductions in polyp number. (aacrjournals.org)
- Conclusion: Suppression of cell proliferation and an increased apoptotic ratio, as well as the ratio of apoptosis to cell proliferation, accompany polyp regression in a chemoprevention trial in FAP patients. (aacrjournals.org)
- Morphology, cell proliferation characteristics, and fission indices of crypts isolated from these lesions were then studied. (bmj.com)
- Analysis of the distribution of mitoses suggested an upward expansion of the proliferation compartment in adenomas to the surface of the crypt with no reversal of proliferating cell distribution, as has previously been described. (bmj.com)
- 150μM, with complete cell death occurring at DC300μM.Inulin inhibits proliferation of HCT 116 cancer cells. (aacrjournals.org)
- In these cells, SDF1α induced proliferation and growth hormone secretion, suggesting a possible regulatory role for this chemokine at pituitary level. (aspetjournals.org)
- In conclusion, we demonstrate that SDF1α causes both proliferation and growth hormone release from pituitary adenoma cells, suggesting that the activation of CXCR4 may represent a novel regulatory mechanism for growth hormone secretion and pituitary cell proliferation, which may contribute to pituitary adenoma development. (aspetjournals.org)
- To get closer insights into potential mechanisms, the chemopreventive potential of different in vitro fermented nut varieties regarding the modulation of genes involved in detoxification (CAT, SOD2, GSTP1, GPx1) and cell cycle (p21, cyclin D2) as well as proliferation and apoptosis was examined in LT97 colon adenoma and primary epithelial colon cells. (nutsforlife.com.au)
- The differential modulation of genes involved in detoxification and cell cycle together with an inhibition of proliferation and induction of apoptosis in adenoma cells might contribute to chemopreventive effects of nuts regarding colon cancer. (nutsforlife.com.au)
- Furthermore, ectopic Egfr activation promotes increased intestinal epithelial cell proliferation and crypt size but a decrease in crypt fission rates ( 9 ). (pnas.org)
- Growth factors induce cell proliferation and are implicated in the multistep process of tumorigenesis.Results suggest a specific juxtacrine mechanism for TGF alpha in pituitary tumorigenesis. (sinoprot.com)
- bis(2-ethylhexyl) phthalate, DEHP and polychlorinated biphenyls, PCB) on growth hormone secretion, the somatostatin and estrogenic pathways, viability and proliferation of rat GH-producing pituitary adenoma (GH3) cells. (elsevier.com)
- None of the pollutants impacted on cell proliferation or viability. (elsevier.com)
- Currently, caveolin-1 is thought to be a negative regulator of cellular proliferation and an enhancer of apoptosis by blocking signal transduction between cell surface membrane receptors and intracellular signaling protein cascades. (biomedcentral.com)
- Great insights will come from integrating the signals of different pathways operating at cell cycle regulation, cellular proliferation, and apoptosis. (bmj.com)
- The current data build on the concept that EGFR-dependent tumor cell proliferation and VEGF/VEGFR2-dependent angiogenesis and survival are distinct key mechanisms in polyp development. (aacrjournals.org)
- The relation between proliferation and apoptosis was studied in colorectal mucosal biopsies ( N =41), tubular adenomas (TA) ( N =104) and tubulovillous adenomas (TVA) ( N =34) from 37 FAP patients. (hindawi.com)
- In a follow‐up group, the mucosa is characterised by a balance between proliferation (S % + G2M % = 19) and apoptotic cells (% = 17). (hindawi.com)
- Intestinal tissues with mutations in Apc have disturbed cell proliferation, differentiation and migration. (cristin.no)
- The labeling index did not exceed 1.2% in any tumor, and there was no effect of 10 nmol/L bFGF on the proliferation of adenoma cells. (elsevier.com)
- White, M. C. / Basic fibroblastic growth factor stimulates prolactin secretion from human anterior pituitary adenomas without affecting adenoma cell proliferation . (elsevier.com)
- Fifty-two cases of pleomorphic adenoma of minor salivary gland origin and seventy-two cases of pleomorphic adenoma of major salivary gland origin were examined for the presence of hyaline cells (plasmacytoid cells). (nih.gov)
- Basal cell adenoma (BCA) of the salivary glands is a rare benign tumor resembling pleomorphic adenoma, but with a prominent basaloid cell layer. (scopemed.org)
- A needle biopsy was then carried out, and the pathological diagnosis was pleomorphic adenoma. (biomedcentral.com)
- Histopathological examination revealed well-demarcated tumor tissues showing typical histologic features of pleomorphic adenoma. (biomedcentral.com)
- The specimen obtained by needle biopsy shows typical histopathologic features of pleomorphic adenoma (PA). (biomedcentral.com)
- Therefore, to determine Wnt signaling in the pleomorphic adenoma tissues, we examined. (elsevier.com)
- The expression of Wnt1 and β-catenin as well as the distribution of various cytoskeletal proteins CK7 and CK13 was examined in 30 cases of pleomorphic adenoma by immunohistochemistry. (elsevier.com)
- Thus, in pleomorphic adenoma, Wnt is involved in tumor cell differentiation of peripheral columnar cells forming solid nests and small peripheral columnar cells forming duct-like structures. (elsevier.com)
- Therefore, Wnt signaling through β-catenin pathway may be involved in the 'mixed' differentiation characteristic of pleomorphic adenoma although another pathway may also be possibly working in other parts of the tumor tissue. (elsevier.com)
- Normal portal tracts are absent, tumour cells are uniform in size and shape but atypical pleomorphic cells with distorted hyperchromatic nuclei may be seen. (bmj.com)
- Chiu NC, Wu HM, Chou YH, Li WY, Chiou YY, Guo WY, Chang CY: Basal Cell Adenoma Versus Pleomorphic Adenoma of the Parotid Gland: CT Findings. (haomsjournal.org)
- Introduction: Among all thyroid nodules 3 to 10% are Hürthle cell (HC) neoplasms classified as either HC adenomas or carcinomas. (endocrine-abstracts.org)
- Epidemiologic studies have consistently shown an inverse association between long-term intake of nonsteroidal anti-inflammatory drugs (NSAIDs), especially aspirin, and incidence of colorectal adenomas and carcinomas relative to nonusers (reviewed in ref. 1 ). (aacrjournals.org)
- Pituitary adenomas are generally divided into three categories dependent upon their biological functioning: benign adenoma, invasive adenoma, and carcinomas. (sinoprot.com)
- To investigate the colonic adenoma-adenocarcinoma progression sequence, DNA ploidy analysis was performed on hyperplastic polyps to adenocarcinomas. (springer.com)
- The effect of different TP53 mutations on the chromosomal stability of a human colonic adenoma derived cell line with endogenous wild type TP53 act. (nih.gov)
- We examined the effect of loss of wild type TP53 activity on the chromosomal stability of a human colonic adenoma derived cell line (designated AA/Cl) by studying transfected variants which express different TP53 mutations. (nih.gov)
- These findings suggest that loss of TP53 activity and/or acquisition of specific TP53 mutations can increase chromosomal instability and resistance to low level DNA damage in human colonic adenoma cells. (nih.gov)
- The two isoforms were discovered to be similarly expressed in colonic epithelial cells. (aacrjournals.org)
- We herein demonstrated that administration of an inducible NO synthase inhibitor, aminoguanidine, significantly suppressed the tumorigenic conversion of human colonic adenoma (FPCK-1-1) cells into adenocarcinoma (FPCK/Inflam) cells accelerated by foreign body-induced chronic inflammation in nude mice. (eurekamag.com)
- Immunohistochemistry revealed increased mPGES immunoreactivity in neoplastic cells in both colorectal adenomas and cancers compared with adjacent normal colonic epithelium. (aacrjournals.org)
- ACTH-secreting adenoma ( adrenocorticotrophic hormone-secreting adenoma ) corticotroph adenoma . (thefreedictionary.com)
- see prolactinoma , corticotroph adenoma , gonadotroph adenoma , growth hormone-secreting adenoma , and thyrotroph adenoma . (thefreedictionary.com)
- 1) c-f os Gene expression of c-fos in corticotroph adenoma cells was greater than that in non-adenoma cells. (nii.ac.jp)
- 2) CRF-R1 mRNA levels were down-regulated by CRF in corticotrophs, but were up-regulated by CRF in corticotroph adenoma cells. (nii.ac.jp)
- 3) DDAVP, V2-agonist, stimulated ACTH secretion from corticotroph adenoma cells, but did not stimulate it in normal ACTH cells. (nii.ac.jp)
- Vib mRNA levels in corticotroph adenoma cells increased after stimulation of VP and CRF.The size of Vib mRNA in adenoma cells was similar to that of authentic V1 b mRNA. (nii.ac.jp)
- these include the sparsely granulated somatotroph adenoma, the lactotroph adenoma in men, the Crooke's cell adenoma , the silent corticotroph adenoma , and the newly introduced plurihormonal Pit-1-positive adenoma (previously known as silent subtype III pituitary adenoma ). (operativeneurosurgery.com)
- Compared with typical corticotroph adenomas, CCAs are aggressive. (operativeneurosurgery.com)
- CCAs represent a distinct entity that should be separated from corticotroph adenomas without Crooke's hyaline change 6) . (operativeneurosurgery.com)
- CONCLUSION: We suggest that the designation 'composite silent corticotroph pituitary adenoma with adrenocortical cells' is an appropriate name for this tumor. (elsevier.com)
- Feig, Denice S. / A composite silent corticotroph pituitary adenoma with interspersed adrenocortical cells : Case report . (elsevier.com)
- Pituitary adenomas are benign, slow-growing neoplasms in the majority of cases, with an incidence of clinically relevant tumours of 4-7 per 100 000 annually. (medscape.com)
- Pituitary adenomas represent a group of functionally diverse neoplasms with relatively high prevalence in the general population. (scielo.br)
- Pituitary adenomas are one of the most common intracranial neoplasms. (scielo.br)
- Basal cell adenoma of salivary glands with a focal cribriform pattern: clinicopathologic and immunohistochemical study of 19 cases of a potential pitfall for diagnosis. (humpath.com)
- Basal cell adenoma is a rare benign neoplasm of the salivary glands. (bvsalud.org)
- They are believed to arise from progenitor cells residing within the ductal tributaries of salivary glands. (cancernetwork.com)
- Ragaa M. Abdel Wahab , Monographic basal cell adenoma of the salivary glands immunocytohistochemical study and histogenesis, J. Egypt. (who.int)
- Seven cases of monomorphic basal cell adenomas of salivary glands were studied with light microscope and immunocyto-histochemically. (who.int)
- abstract = "Purpose The purposes of this study were to investigate the correlation between unenhanced CT attenuation values and 18F-FDG uptake in adrenal adenomas, and to clarify the mechanism of FDG uptake in adrenal adenomas based on immunohistochemical findings. (elsevier.com)
- abstract = "An increased rate of acromegaly was reported in industrialized areas, suggesting an involvement of environmental pollutants in the pathogenesis and behavior of GH-secreting pituitary adenomas. (elsevier.com)
- Abstract Reported herein is a 25-year-old woman who was treated for a large and highly atypical prolactin-producing pituitary adenoma. (uga.edu)
- abstract = "OBJECTIVE AND IMPORTANCE: A case report of an extraordinary sellar pituitary tumor composed of corticotrophs and adrenocortical cells is presented. (elsevier.com)
Type of pituitary2
- Play media Hürthle cells are characterized as enlarged epithelial cells. (wikipedia.org)
- This study emphasises the different biological consequences of individual TP53 mutations on the genotype of premalignant colorectal epithelial cells and subsequent implications for tumorigenic progression. (nih.gov)
- Further work is underway investigating the effect of inulin and bile-acid on NF-κB, p53 and apoptosis in adenocarcinoma and normal dermal HK epithelial cells. (aacrjournals.org)
- In primary epithelial cells, expression of CAT (up to 3.5-fold), GSTP1 (up to 3.0-fold), and GPx1 (up to 3.9-fold) was increased, whereas p21 and cyclin D2 levels were not influenced. (nutsforlife.com.au)
- Canalicular adenoma is defined as a tumor composed of columnar epithelial cells arranged in thin, anastomosing cords with a beaded pattern. (medscape.com)
- Stem-like cells are present in colorectal adenomas, but their relationship to adenoma pathology and patient characteristics, including metachronous development of an additional adenoma ("recurrence"), have not been studied extensively. (aacrjournals.org)
- The pathology of prolactinomas involves dysfunction of lactotrophic cells in the anterior pituitary gland which in turn leads to hyperprolactinemia [ 1 ]. (biomedcentral.com)
- You could add Molecular pathology of pituitary adenomas to a list if you log in . (openlibrary.org)
- Are you sure you want to remove Molecular pathology of pituitary adenomas from your list? (openlibrary.org)
- Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. (nih.gov)
- In this study, the APC(Min/+) mouse model of intestinal adenomatous polyposis was used to investigate tumor-associated lymphocyte subsets and the mechanisms of their accumulation into gastrointestinal adenomas. (diva-portal.org)
- Regression of intestinal adenomas by vaccination with heat shock protein 105-pulsed bone marrow-derived dendritic cells in Apc(Min/+) mice. (docphin.com)
- Yokomine K, Nakatsura T, Senju S, Nakagata N, Minohara M, Kira J, Motomura Y, Kubo T, Sasaki Y, Nishimura Y. Regression of intestinal adenomas by vaccination with heat shock protein 105-pulsed bone marrow-derived dendritic cells in Apc(Min/+) mice. (docphin.com)
- Because Apc(Min/+) mice develop multiple adenomas throughout the intestinal tract by 4 months of age, the mice provide a clinically relevant model of human intestinal tumor. (docphin.com)
- The Apc Min/+ mouse is a well-characterized in vivo model of intestinal tumorigenesis, and animals with this genetic mutation develop macroscopically detectable adenomas from ∼6 weeks of age. (aacrjournals.org)
- Paneth and enterochromaffin cells were studied in the intestine and intestinal adenomas from Min-mice with heterozygote and homozygote mutations in Apc, respectively. (cristin.no)
- RESULTS: Min-mice intestinal adenomas had an increased number of lysozyme-producing Paneth/goblet and non-Paneth cells and a reduced number of enterochromaffin cells. (cristin.no)
- These cells are often found in the thyroid. (wikipedia.org)
- This treatment option is used to destroy infected thyroid cells after total thyroidectomy. (wikipedia.org)
- Hsa-microRNA-101 suppresses migration and invasion by targeting Rac1 in thyroid cancer cells. (biomedsearch.com)
- So, signet- ring cell adenoma of the thyroid is extremely rare. (ejmo.org)
- We represent signet-ring cell adenoma of thyroid gland in this case report. (ejmo.org)
- In all functioning thyroid nodules (toxic adenomas), a high expression of hNIS protein was detected with respect to normal surrounding tissue. (unical.it)
- Similar to the normal thyroid tissue, follicular cells of toxic thyroid adenomas showed an exclusive expression of hNIS protein at the cell membrane. (unical.it)
- Fifty-four percent of benign nonfunctioning thyroid nodules overexpressed hNIS protein compared with the normal surrounding tissue, but in these nodules the hNIS protein failed to target the cell membrane, being mostly localized inside the cytoplasm, hNIS protein was not detected by immunohistochemistry in 46% of nonfunctioning nodules, whereas it was expressed in the surrounding unaffected thyroid tissue. (unical.it)
- In conclusion, the results obtained in this study show that two mechanisms contribute to the reduced radioiodide uptake typical of benign nonfunctioning thyroid nodules: 1) reduced expression of the hNIS protein, and 2) defective targeting of hNIS to the cell membrane. (unical.it)
- Fish oil supplementation can reduce cytokinetic anomalies in the flat rectal mucosa of patients with sporadic colorectal adenoma. (nih.gov)
- Residual paraffin-embedded adenomas and normal mucosa from the same patients ( n = 17) or normal tissue alone ( n = 15) were analyzed. (aacrjournals.org)
- Ki-67 and apoptotic labeling indices and their ratios were calculated in superficials (s) and nonsuperficial (ns) regions of adenomas and normal mucosa, and baseline to 6-month differences were calculated. (aacrjournals.org)
- Canalicular adenoma typically presents as a painless, slowly enlarging submucosal mass covered by intact mucosa that ranges in color from normal to slightly blue, often mimicking a mucocele. (medscape.com)
- Tumor development in colorectal cancer is characterized by cells within the normal mucosa acquiring multiple genetic mutations. (aacrjournals.org)
- Pituitary adenomas represent an inhomogenous tumor entity in terms of growth rate, invasiveness and recurrence. (springer.com)
- Most are functional adenomas occurring in middle-aged women and are invasive macroadenomas prone to recurrence. (operativeneurosurgery.com)
- Even standard pituitary adenomas exhibit relatively high long-term recurrence rates and delayed intervention is often required. (medscape.com)
- The primary objective of this study is to investigate recurrence rates of colorectal adenoma (CRA) after calcium plus vitamin D intervention. (clinicaltrials.gov)
- The recurrence rates of advanced colorectal adenoma (A-CRA) after calcium plus vitamin D intervention. (clinicaltrials.gov)
- There are several explanations for tumor recurrence, including cellular dormancy or quiescence that allow cancer cells to persist and reenter the cell cycle after a latent period or therapy-induced stimulation. (rupress.org)
- However, their true molecular identity and the mechanisms underlying dormancy remain elusive, and there is an urgent need to identify compounds that can perturb this dormant state to enable more complete cancer cell killing to prevent late recurrence. (rupress.org)
- An important prognostic factor for the surgical outcome and recurrence of a pituitary adenoma is its invasiveness into parasellar tissue, particularly into the space of the cavernous sinus (CS). (thejns.org)
- These cells are often benign, but they can be malignant and metastasize. (wikipedia.org)
- Here, we present a case of a HC adenoma proved to be malignant 11 years post-thyroidectomy. (endocrine-abstracts.org)
- There was no focal capsular invasion of malignant cells or infiltration into the adjacent normal tissue. (biomedcentral.com)
- Subtype of salivary basal cell adenoma . (humpath.com)
- A subtype of hepatocellular adenoma (HCA) is also caused by biallelic somatic HNF1A mutations (H-HCA), and rare HCA may be related to MODY3. (diabetesjournals.org)
- Bioulac-Sage P, Balabaud C, Zucman-Rossi J. Subtype classification of hepatocellular adenoma. (medscape.com)
- Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry. (medscape.com)
- hepatocellular adenoma a large, fleshy, hypervascular tumor of the liver occurring chiefly in women of childbearing age and associated with oral contraceptive use. (thefreedictionary.com)
- Hepatocellular adenoma (HCA) is a rare, benign, liver tumor frequently associated with oral contraception ( 1 , 2 ). (diabetesjournals.org)
- Which physical findings are characteristic of hepatocellular adenoma (HCA)? (medscape.com)
- Epidemiology of hepatocellular adenoma. (medscape.com)
- Management of focal nodular hyperplasia and hepatocellular adenoma in young women: a series of 41 patients with clinical, radiological, and pathological correlations. (medscape.com)
- Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience. (medscape.com)
- Bioulac-Sage P, Taouji S, Possenti L, Balabaud C. Hepatocellular adenoma subtypes: the impact of overweight and obesity. (medscape.com)
- Rebouissou S, Bioulac-Sage P, Zucman-Rossi J. Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma. (medscape.com)
- The dopamine D 2 receptor agonist bromocriptine has been widely used clinically to treat human breast tumor and prolactinoma through inhibition of hyperprolactinemia and induction of tumor cell apoptosis, respectively, but the molecular mechanism of bromocriptine induction of pituitary tumor apoptosis remains unclear. (biomedcentral.com)
- Rat pituitary adenoma GH3 cells, which express endogenous caveolin-1, exhibit increased apoptosis and shrinkage after exposure to bromocriptine. (biomedcentral.com)
- Transiently expressed mouse recombinant caveolin-1 induced apoptosis in GH3 cells by enhancing the activity of caspase 8. (biomedcentral.com)
- Significantly, caveolin-1 induction of GH3 cell apoptosis was sensitized by the administration of bromocriptine. (biomedcentral.com)
- Phosphorylation of caveolin-1 at tyrosine 14 was enhanced after bromocriptine treatment, suggesting that bromocriptine-induced phosphorylation of caveolin-1 may contribute to sensitization of apoptosis in GH3 cells exposed to bromocriptine. (biomedcentral.com)
- Our results reveal that caveolin-1 increases sensitivity for apoptosis induction in pituitary adenoma GH3 cells and may contribute to tumor shrinkage after clinical bromocriptine treatment. (biomedcentral.com)
- These data demonstrate that an up-regulation of caveolin-1 may be involved in promoting cell apoptosis. (biomedcentral.com)
- Recently, we obtained bromocriptine induced apoptosis in murine ACTH-secreting pituitary adenoma (AtT-20) cells, based on DNA fragmentation assay and cell cycle analysis (unpublished data). (edu.au)
- In this study, we demonstrate that enforced expression of bcl-2 gene in AtT-20 cells by the MPZenNeo(bcl-2) retroviral gene transfer increased resistance to apoptosis induced by bromocriptine. (edu.au)
- The process of tumorigenesis is characterised by a stepwise increase in resistance to apoptosis followed by an increase in cycling cells. (hindawi.com)
Development of pituitary adenomas2
- Also, stem and progenitor cells are thought to play a role in pituitary tumorigenesis, such as the development of pituitary adenomas in dogs. (uu.nl)
- This review focuses on recent data that explain the mechanism by which HMGA2 induces the development of pituitary adenomas in mice. (biomedcentral.com)
- A parathyroid gland adenoma composed predominantly of neoplastic chief cells. (semanticscholar.org)
- Parathyroid chief cell adenoma associated with massive chronic parathyroiditis in a woman with hyperparathyroidism. (semanticscholar.org)
- Metachronous double parathyroid adenomas involving two different cell types: chief cell and oxyphil cell. (semanticscholar.org)
- Abbreviation used: WCCA - water clear cell adenoma of parathyroid gland. (exp-oncology.com.ua)
- We herein report a case of primary hyperparathyroidism in a 64-year-old woman with adenoma of the upper left parathyroid gland. (exp-oncology.com.ua)
- 1. Hussein SE, Poppiti R. Water clear cell adenoma of the parathyroid gland: a forgotten cause of primary hyperparathyroidism. (exp-oncology.com.ua)
- Primary hyperparathyroidism caused by enormous unilateral water-clear cell parathyroid hyperplasia. (exp-oncology.com.ua)
- Water-clear parathyroid adenoma: report of two cases and literature review. (exp-oncology.com.ua)
- A rare parathyroid gland adenoma composed of neoplastic cells with abundant cytoplasm. (semanticscholar.org)
- An unusual cause of hypercalcemic crisis: Water-clear cell double parathyroid adenoma. (semanticscholar.org)
- Data from nine reported patients with water-clear cell parathyroid adenomas in the literature. (semanticscholar.org)
- Intrathyroidal water-clear cell parathyroid adenoma: a case report. (semanticscholar.org)
- Methods: An exploratory set of 20 baseline adenomas was analyzed by ALDH1A1 immunohistochemistry with morphometry, and a replication set of 89 adenomas from 76 high-risk participants was evaluated by computerized image analysis. (aacrjournals.org)
- After microdissection, DNA from 25 liver cell adenomas and corresponding normal liver tissue were analysed for INK4-ARF inactivation by DNA sequence analysis, methylation specific polymerase chain reaction, restriction enzyme related-polymerase chain reaction (RE-PCR), mRNA expression, microsatellite analysis, and immunohistochemistry. (bmj.com)
- Immunohistochemistry with a panel of steroidogenic dehydrogenases and hydroxylases was positive in the large cells, confirming these as adrenocortical cells. (elsevier.com)
- lactotrope adenoma ( lactotroph adenoma ) prolactinoma . (thefreedictionary.com)
- Pit-1 immunostaining is not routinely used in the characterization of pituitary adenomas, and its utility in distinguishing adenomas dedicated towards the lactotroph, somatotroph, and thyrotroph lineage from null cell adenomas warrants further evaluation. (elsevier.com)
- Background: The histogenesis of human colorectal hyperplastic polyps and colorectal adenomas is poorly understood even now. (bmj.com)
- Conclusions: Sporadic human colorectal adenomas and hyperplastic polyps grow by the process of crypt fission. (bmj.com)
- The role of Egfr signaling during later stages of tumorigenesis was examined by using nude mice xenografts of two human colorectal cancer cell lines. (pnas.org)
- Overexpression of HMGA2 gene leads to the onset of prolactin and GH-hormone induced pituitary adenomas in mice, suggesting a critical role of this protein in pituitary tumorigenesis. (biomedcentral.com)
- These data suggested VEGF signaling may be important in early tumorigenesis, at the stage of adenoma formation ( 14 ). (aacrjournals.org)
- Pituitary adenoma formation is generally considered to be the result of the clonal expansion of a single mutated cell (3) and molecular studies have identified a number of genetic and epigenetic abnormalities that may have a possible causative or facilitatory role in pituitary tumorigenesis. (scielo.br)
- Basal cell adenoma of the parotid gland. (wikipedia.org)
- Synchronous unilateral basal cell adenoma of the parotid gland: A case report. (biomedsearch.com)
- We present 3 cases of basal cell adenoma of the parotid treated at our Department. (haomsjournal.org)
- García RG, Cha SHN, Muñoz Guerra MF, Gamallo Amat C: Basal cell adenoma of the parotid gland. (haomsjournal.org)
- Scheller EL, Pritchett CV, Shukla A, Pepper JP, Marentette LJ, McHugh JB: Synchronous ipsilateral sebaceous lymphadenoma and mem- branous basal cell adenoma of the parotid. (haomsjournal.org)
- There are reports of histologically characterized HC adenomas with unpredictable clinical course. (endocrine-abstracts.org)
- It is recommended that all adult cases histologically resembling metanephric adenoma have WT1, CD57, CK7, and AMACR immunohistochemical staining performed. (sigmaaldrich.com)
- Additionally, there is a subset of histologically aggressive adenomas which display early and multiple recurrences despite multimodal therapy. (medscape.com)
- Histologically, the specimen was composed of polygonal or spindle cells showing marked nuclear pleomorphism and/or multinucleation. (biomedcentral.com)
- Differing contributions from these cell types produce a wide variety of histologically distinct patterns. (cancernetwork.com)
- Histologically, two cell types could be readily distinguished, i.e., small basophilic cells that were positive for periodic acid Schiff and adrenocorticotropic hormone and large cells with abundant, slightly vacuolated, eosinophilic cytoplasm that were negative for periodic acid Schiff and adrenocorticotropic hormone. (elsevier.com)
- Hürthle cell adenoma is a rare benign tumor, typically seen in women between the ages of 70 and 80 years old. (wikipedia.org)
- A benign tumor of the pancreatic ISLET CELLS. (rush.edu)
- Null cell adenoma is a benign tumor in the pituitary gland, the pea-sized organ in the center of the brain and just above the back of the nose. (adventhealthneuroinstitute.com)
- The inhibitor also induced goblet cell differentiation in adenomas in mice carrying a mutation of the Apc tumour suppressor gene. (nih.gov)
- To clarity the mechanism of hypersecretion of ACTH and the resistance of ACTH secretion to glucocorticoid, (1) gene expression of c-fos, (2) gene expression of CRF-R1, (3) response of ACTH to DDAVP and characterization of Vi b mRNA were studied in ACTH-producing pituitary adenoma cells. (nii.ac.jp)
- An important gene associated with Mixed Cell Adenoma is CTSD (Cathepsin D), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System . (malacards.org)
- The tumour suppressor gene p16 INK4a is believed to encode a negative regulatory protein that controls the progression of eucaryotic cells through the G1 phase of the cell cycle by interacting with CDK4 and inhibiting its kinase activity. (bmj.com)
- However, the classical gene alterations involved in cell transformation, such as ras , BRAF , Rb , do not appear to be responsible for the onset of pituitary adenomas [ 3 ]. (biomedcentral.com)
- Only up to 40% of sporadic human GH-secreting adenomas have missense mutations of the Gsα gene [ 4 ], and many functional adenomas present the overexpression of a recently discovered powerful transforming gene, PTTG , which is able to exert strong transforming effects both in vitro and in vivo [ 5 ]. (biomedcentral.com)
- This allows β-catenin to migrate to the nucleus where it activates gene transcription and cell division through binding to T-cell factor ( 3 ). (aacrjournals.org)
- Objective: The objective of the study was to define the effect of the KCNJ5 mutations on gene expression and aldosterone production using APA tissue and human adrenocortical cells. (elsevier.com)
- Germline mutations in the aryl-hydrocarbon interacting protein gene are identified in around 25% of familial isolated pituitary adenoma kindreds. (scielo.br)
- Pituitary adenomas with mutations of the aryl-hydrocarbon interacting protein gene are predominantly somatotropinomas and prolactinomas, but non-functioning adenomas, Cushing disease, and thyrotropinoma may also occur. (scielo.br)
- These include somatic mutations in the gsp oncogene, overexpression of the pituitary tumor transforming gene ( PTTG ), disruptions in cell cycle regulation and intracellular signaling pathways and, rarely, mutations of classic oncogenes (4,5). (scielo.br)
- In this protocol, we are modifying the patients white blood cells with a retrovirus that has the gene for anti-mesothelin incorporated in the retrovirus. (clinicaltrials.gov)
- We have further established a protocol for the differentiation from human iPS cells into pituitary in vitro. (nii.ac.jp)
- For instance, although Egfr activity is not required for the initiation of squamous papillomas derived from ras Ha -transformed keratinocytes, an Egfr autocrine loop is essential for maintenance of papilloma growth and prevention of terminal differentiation of dysplastic cells ( 14 , 15 ). (pnas.org)
- There are well known that Wnt signaling was some roles of cell differentiation at the development tissues, especially the oral and maxillofacial regions of some developmental stages. (elsevier.com)
- Moreover, among the three currently known Wnt pathways, β-catenin is the suggested pathway working during cell differentiation. (elsevier.com)
- CONCLUSION: Altered cell differentiation in adenomas might be caused by different response to Wnt-signalling, while an increased number of enterochromaffin cells in the large intestine is rather an effect of a heterozygous Apc(Min) mutation. (cristin.no)
- 1. Pituitary adenomas are benign and slow-growing tumours whose clinical manifestations depend mainly on the secretory activity of the adenomatous cells. (clinsci.org)
- Further, we correlated the two markers, and defined the clinical value of Topo-IIα in pituitary adenomas as compared to MIB-1. (springer.com)
- This neoplasm has a low endocrine activity, making clinical manifestation only when the adenoma become large enough for causing high serum calcium levels . (exp-oncology.com.ua)
- In addition to the accurate tumor subtyping, assessment of the tumor proliferative potential by mitotic count and Ki-67 index, and other clinical parameters such as tumor invasion, is strongly recommended in individual cases for consideration of clinically aggressive adenomas. (operativeneurosurgery.com)
- Neurosurgeons and physicians dealing with pituitary adenomas diagnosed as Crooke's cell adenomas have to be aware of their potential clinical aggressiveness to plan strict follow-up of patients and eventual multimodality treatment 3) . (operativeneurosurgery.com)
- The clinical course of pituitary adenoma can be highly variable. (medscape.com)
- Our case highlights the difficulty in definitively diagnosing an unusual prolactin-producing adenoma based on histopathology alone and the importance of referring to clinical information and immunohistochemical findings when deriving the diagnosis. (biomedcentral.com)
- Familial isolated pituitary adenoma is a recently defined clinical entity, and is characterized by hereditary presentation of pituitary adenomas in the absence of clinical and genetic features of syndromic disease such as multiple endocrine neoplasia type 1 and Carney complex. (scielo.br)
- Reports from the same center confirmed the condition as a new clinical entity, and the term familial isolated pituitary adenomas (FIPA) was adopted (9-11). (scielo.br)
- With patients who underwent surgery due to clinical signs without histological evidence for malignancy, apoptotic cells in TA continue to decrease significantly (9%), without any changes in cycling cells. (hindawi.com)
- Thus, we identified three miRNAs (hsa-miR-421, hsa-miR-29b-1-5p, and hsa-miR-27b-5p) with two mRNAs (FBXO11 and CREBZF) that might play an important role in the GC development from premalignant adenomas. (medsci.org)
- It is concluded that multistep adenoma-adenocarcinoma progression was partially reflected in DNA ploidy pattern from hyperplastic polyps to villous adenomas. (springer.com)
- Methods: HCT116 adenocarcinoma cells were treated with inulin at different concentrations and stopped at various time ranges (30 minutes - 24 hours). (aacrjournals.org)
- These results showed that NO was one of the causative factors for the acceleration of colon carcinogenesis, especially in the conversion from adenoma to adenocarcinoma in the chronic inflammatory environment. (eurekamag.com)
- The AdventHealth Neuroscience Institute is a state-of-the-art facility for adults and children affected by null cell adenoma. (adventhealthneuroinstitute.com)
- The new definition of the Null cell adenoma requires the demonstration of immunonegativity for pituitary transcription factors and adenohypophyseal hormones Moreover, the term of atypical pituitary adenoma is no longer recommended. (operativeneurosurgery.com)
Therapeutic agent for patients with prolactinomas1
- Bromocriptine, a dopamine agonist, is now an accepted primary therapeutic agent for patients with prolactinomas and other pituitary adenomas. (edu.au)
- All the pollutants induced a statistically significant increase in GH secretion and interfered with cell signaling. (elsevier.com)
- Present data demonstrate that exposure to different pollutants, used at in vivo relevant concentrations, plays an important role in the behavior of GH3 pituitary adenoma cells, by increasing GH secretion and modulating several cellular signaling pathways. (elsevier.com)
- These results suggest that bFGF may have a paracrine role in the stimulatory regulation of PRL secretion in human pituitary adenomas, and these effects are most likely due to increased hormonal synthesis. (elsevier.com)
- The signet-ring formation of follicular cells is uncommon morphology. (ejmo.org)
Basal cell adenomas2
Liver cell adenomas4
- Methylation of p14 ARF was found in 3/25 cases (12%) and alterations in p16 INK4a occurred in 6/25 liver cell adenomas (24%) which correlated with loss of mRNA transcription. (bmj.com)
- Our data suggest that p14 ARF methylation occurs independently of p16 INK4a alterations in liver cell adenomas. (bmj.com)
- Edmondson HA, Henderson B, Benton B. Liver-cell adenomas associated with use of oral contraceptives. (medscape.com)
- Regression of liver cell adenomas associated with oral contraceptives. (medscape.com)
- Purpose The purposes of this study were to investigate the correlation between unenhanced CT attenuation values and 18 F-FDG uptake in adrenal adenomas, and to clarify the mechanism of FDG uptake in adrenal adenomas based on immunohistochemical findings. (elsevier.com)
Adopted a pituitary1
- Recognizing this novel approach, the fourth edition of the WHO classification has abandoned the concept of "a hormone-producing pituitary adenoma" and adopted a pituitary adenohypophyseal cell lineage designation of the adenomas with subsequent categorization of histological variants according to hormone content and specific histological and immunohistochemical features. (operativeneurosurgery.com)
- A surprising finding was that S-phase percentage in adenocarcinomas was not parallel with PCNA-positive tumor cell numbers. (springer.com)
- Conclusions: A larger population of ALDH1A1-expressing cells in an adenoma is associated with a higher risk for metachronous adenoma, independent of adenoma size or histopathology. (aacrjournals.org)
- Only MIB-1 but not Topo-IIα demonstrated significantly higher values in invasive adenomas. (springer.com)
- Oxyphil-cell adenoma (oncocytoma) of the caruncle (author's t. (mysciencework.com)
- The FAP phenotype consists of at least hundreds of colorectal adenomas and the eventual development of colorectal cancer ( 3 -7 ). (aacrjournals.org)
- 17 Experimental merit for this hypothesis has come from studies in the telomerase deficient mouse (mTERC −/− ) showing that critical telomere shortening leads to elevated rates of spontaneous cancer during aging 18 and increased initiation of aberrant crypt and micro-adenomas during the time course of colorectal cancer formation. (bmj.com)
- Chenodeoxycholate markedly induced COX-2 but not mPGES in colorectal cancer cells. (aacrjournals.org)
- Cellular dormancy and heterogeneity in cell cycle length provide important explanations for treatment failure after adjuvant therapy with S-phase cytotoxics in colorectal cancer (CRC), yet the molecular control of the dormant versus cycling state remains unknown. (rupress.org)
- Evaluating the risk of colorectal metachronous adenoma (MA), which is a precancerous lesion, is necessary for metachronous colorectal cancer (CRC) precaution among CRC patients who had underwent surgical removal of their primary tumor. (frontiersin.org)
- In adenocarcinomas, the Dukes classification paralleled well the DNA ploidy status from stage A diploid to stage D aneuploid, but was not accompanied by increasing PCNA-positive cell numbers. (springer.com)
- although classically they were considered to be composed of sparsely granulated or degranulated (nonfunctioning) cells, some contain functioning cells and may be associated with a hyperpituitary state such as acromegaly or Cushing's syndrome. (thefreedictionary.com)
- Pit-1 immunostaining can recognize rare cases of sparsely granulated somatotroph adenomas that appear immunonegative for growth hormone, as well as rare cases of other Pit-1-positive adenomas that are negative for Pit-1 lineage hormones. (elsevier.com)
- It was found that the proportion of cells with more than 4% aberrations was significantly greater in the AA/273p53/B cell line (an approximate 5-Fold increase) than in the vector control or the AA/143p53/A cell line. (nih.gov)
- Recently, the selective COX-2 inhibitor celecoxib given continuously to FAP patients for 6 months was found to significantly regress the number of colorectal adenomas compared with placebo ( 9 ). (aacrjournals.org)
- PG significantly up-regulated both the transcripts in HEK293 cells. (aacrjournals.org)
- Nut FS significantly inhibited growth of LT97 cells and increased levels of early apoptotic cells (8.4% on average) and caspase 3 activity (4.6-fold on average), whereas caspase 3 activity was not modulated in primary colon cells. (nutsforlife.com.au)
- Participants in both sample sets who developed a metachronous adenoma had significantly higher ALIs in their baseline adenoma than participants who remained adenoma-free. (aacrjournals.org)
- The direct endoscopic view confirmed the low rate of invasion of Grade 1 adenomas but showed significantly lower rates of invasion in Grade 2 and 3 adenomas than those previously found using the microscopic technique. (thejns.org)
- The large intestine had a significantly higher number of enterochromaffin cells than the small intestine and more were seen in the large intestine of Min- compared with wt-mice. (cristin.no)
- Background: Celecoxib was shown to regress colorectal adenomas in familial adenomatous polyposis (FAP) patients relative to placebo. (aacrjournals.org)
- Traditionally, familial pituitary adenomas have been associated with some multiple neoplasia syndromes, including multiple endocrine neoplasia type 1 (MEN 1), Carney complex, and the newly defined multiple endocrine neoplasia type 4. (scielo.br)
- The first single-center study to specifically scout for cases of familial pituitary adenomas unrelated to MEN 1 and Carney complex was performed in Liege, Belgium in the 1990s, and led to the identification of an initial cohort of 27 patients (8). (scielo.br)