Neoadjuvant Therapy: Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.Pancreaticoduodenectomy: The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Chemoradiotherapy: Treatment that combines chemotherapy with radiotherapy.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.DeoxycytidineAntimetabolites, Antineoplastic: Antimetabolites that are useful in cancer chemotherapy.Antibodies, Monoclonal, Humanized: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.Cell Line, Tumor: A cell line derived from cultured tumor cells.Angiogenesis Inhibitors: Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.Manuscripts, MedicalJapanSocieties, Medical: Societies whose membership is limited to physicians.Vascular Surgical Procedures: Operative procedures for the treatment of vascular disorders.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Practice Guidelines as Topic: Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.Iatrogenic Disease: Any adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.Aneurysm, False: Not an aneurysm but a well-defined collection of blood and CONNECTIVE TISSUE outside the wall of a blood vessel or the heart. It is the containment of a ruptured blood vessel or heart, such as sealing a rupture of the left ventricle. False aneurysm is formed by organized THROMBUS and HEMATOMA in surrounding tissue.Aneurysm, Infected: Aneurysm due to growth of microorganisms in the arterial wall, or infection arising within preexisting arteriosclerotic aneurysms.Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)Abscess: Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.Aneurysm: Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.Ovarian Hyperstimulation Syndrome: A complication of OVULATION INDUCTION in infertility treatment. It is graded by the severity of symptoms which include OVARY enlargement, multiple OVARIAN FOLLICLES; OVARIAN CYSTS; ASCITES; and generalized EDEMA. The full-blown syndrome may lead to RENAL FAILURE, respiratory distress, and even DEATH. Increased capillary permeability is caused by the vasoactive substances, such as VASCULAR ENDOTHELIAL GROWTH FACTORS, secreted by the overly-stimulated OVARIES.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.NepalArteriovenous Malformations: Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They usually are crooked, dilated, and with thick vessel walls. A common type is the congenital arteriovenous fistula. The lack of blood flow and oxygen in the capillaries can lead to tissue damage in the affected areas.Portal Vein: A short thick vein formed by union of the superior mesenteric vein and the splenic vein.Intracranial Arteriovenous Malformations: Congenital vascular anomalies in the brain characterized by direct communication between an artery and a vein without passing through the CAPILLARIES. The locations and size of the shunts determine the symptoms including HEADACHES; SEIZURES; STROKE; INTRACRANIAL HEMORRHAGES; mass effect; and vascular steal effect.Hypertension, Portal: Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.Venous Thrombosis: The formation or presence of a blood clot (THROMBUS) within a vein.Esophageal and Gastric Varices: Dilated blood vessels in the ESOPHAGUS or GASTRIC FUNDUS that shunt blood from the portal circulation (PORTAL SYSTEM) to the systemic venous circulation. Often they are observed in individuals with portal hypertension (HYPERTENSION, PORTAL).Telangiectasia, Hereditary Hemorrhagic: An autosomal dominant vascular anomaly characterized by telangiectases of the skin and mucous membranes and by recurrent gastrointestinal bleeding. This disorder is caused by mutations of a gene (on chromosome 9q3) which encodes endoglin, a membrane glycoprotein that binds TRANSFORMING GROWTH FACTOR BETA.Medical Illustration: The field which deals with illustrative clarification of biomedical concepts, as in the use of diagrams and drawings. The illustration may be produced by hand, photography, computer, or other electronic or mechanical methods.Curriculum: A course of study offered by an educational institution.Teaching: The educational process of instructing.Cardiac-Gated Imaging Techniques: Timing the acquisition of imaging data to specific points in the cardiac cycle to minimize image blurring and other motion artifacts.Credentialing: The recognition of professional or technical competence through registration, certification, licensure, admission to association membership, the award of a diploma or degree, etc.Pennisetum: A plant genus of the family POACEAE. The seed is one of the millets used in EDIBLE GRAIN. It contains vitexin. The common name of buffelgrass is also used for CENCHRUS.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Anastomosis, Surgical: Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.Blood Vessel Prosthesis: Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.Prosthesis Design: The plan and delineation of prostheses in general or a specific prosthesis.Blood Vessel Prosthesis Implantation: Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.Aortic Aneurysm, Abdominal: An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.Stents: Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.

*Vitelline arteries

They give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery. "vitelline arteries ( ... The vitelline arteries are the arterial counterpart to the vitelline veins. Like the veins, they play an important role in the ...

*Michael L. Marin

PMID 10958293 Management of aneurysms involving branches of the celiac and superior mesenteric arteries: A comparison of ... 2004 ;13 :221-6 15744694 (P,S,E,B) PMID 15744694 Endovascular repair of an infected carotid artery pseudoaneurysm. Donald T ...

*Lumbar vertebrae

... superior mesenteric artery, termination of spinal cord, beginning of filum terminalis, renal vessels, middle suprarenal ... Other important structures are also located at this level, they include; fundus of the gall bladder, celiac trunk, ... arteries, and hila of kidneys. The fifth lumbar vertebra is characterized by its body being much deeper in front than behind, ... The superior and inferior articular processes are well-defined, projecting respectively upward and downward from the junctions ...

*Bühler's anastomotic artery

... is an anastomotic shunt joining the superior mesenteric artery and the celiac trunk in vertical orientation. As the aforesaid ... arteries arise separately from different levels of the abdominal aorta, the shunt provides limited collateral circulation ... Bühler's artery is a rare phenomenon present in up to 3% of the population, and is thought to be an unobliterated remnant of ... In human anatomy, Bühler's anastamotic artery (also called the arc of Bühler) ...

*Stomach

... the celiac artery, superior mesenteric artery, and inferior mesenteric artery. The areas supplied by these arteries are used to ... The sac is surrounded by a network of vitelline arteries. Over time, these arteries consolidate into the three main arteries ... Greater omentum and stomach of humans Human stomach A more realistic image, showing the celiac artery and its branches in ... The lesser curvature of the human stomach is supplied by the right gastric artery inferiorly, and the left gastric artery ...

*Esophagus

... the celiac artery, superior mesenteric artery, and inferior mesenteric artery. The areas supplied by these arteries are used to ... The sac is surrounded by a network of vitelline arteries. Over time, these arteries consolidate into the three main arteries ... All these veins drain into the superior vena cava, with the exception of the left gastric vein, which is a branch of the portal ... The upper parts of the esophagus and the upper esophageal sphincter receive blood from the inferior thyroid artery, the parts ...

*Radiation lobectomy

... artery via Seldinger technique and advances a wire and catheter to the level of the superior mesenteric artery and the celiac ... right hepatic and phrenic arteries. The purpose of this planning angiogram is to evaluate for anatomical variants and ... Radiation lobectomy: after gaining femoral artery access and advancing a catheter in the right hepatic artery (most often), 90Y ... It consists of injecting small radioactive beads loaded with yttrium-90 into the hepatic artery feeding the hepatic lobe in ...

*Celiac plexus

... near where the celiac trunk, superior mesenteric artery, and renal arteries branch from the abdominal aorta. It is behind the ... ovarian plexus Superior mesenteric plexus Inferior mesenteric plexus The celiac plexus is often popularly referred to as the ... Intractable pain related to chronic pancreatitis is an important indication for celiac plexus ablation. Cardiac plexus Superior ... The celiac plexus proper consists of the celiac ganglia with a network of interconnecting fibers. The aorticorenal ganglia are ...

*Pancreaticoduodenectomy

... supply of the pancreas is from the celiac artery via the superior pancreaticoduodenal artery and the superior mesenteric artery ... the superior pancreaticoduodenal artery and inferior pancreaticoduodenal artery). These arteries run through the head of the ... If the tumor encases (wraps around 50% or more of the vessel) the celiac artery, superior mesenteric artery, or inferior vena ... such as celiac artery, inferior vena cava, or superior mesenteric artery) as mentioned above. Clinical trials have failed to ...

*Suspensory muscle of duodenum

... continues as connective tissue around the stems of the celiac trunk (celiac artery) and superior mesenteric artery, passes ... an upper tendinous portion blending with connective tissue around the origins of the superior mesenteric and coeliac arteries. ... and duodenojejunal flexure to connective tissue surrounding the superior mesenteric artery and coeliac artery. It is also known ... Superior mesenteric artery syndrome is a rare abnormality caused by a congenitally-short suspensory muscle. The duodenum and ...

*Pancreaticoduodenal artery

... artery In case of a coarctation of the aorta located between the celiac trunk and the superior mesenteric artery, the ... Pancreaticoduodenal artery (arteries to the pancreas and duodenum) can refer to: Superior pancreaticoduodenal artery Inferior ... anastomosis between these arteries can provide an alternative route for blood flow, called the pancreaticoduodenal arcade.. ...

*Aorta

... and visceral arteries (the celiac trunk, the superior mesenteric artery and the inferior mesenteric artery). It ends in a ... Its lowest pair of branches are the superior phrenic arteries, which supply the diaphragm, and the subcostal arteries for the ... Together, these two arteries supply the heart. The posterior aortic sinus does not give rise to a coronary artery. For this ... The thoracic descending aorta gives rise to the intercostal and subcostal arteries, as well as to the superior and inferior ...

*Transcatheter arterial chemoembolization

... angiogram of the celiac trunk and possibly the superior mesenteric artery to identify the branches of the hepatic artery ... and development of unpaired arteries (a vital component of tumor angiogenesis). All these events lead to a gradual shift in ... through the celiac trunk and common hepatic artery, and finally into the branch of the proper hepatic artery supplying the ... The patient must lie stationary for several hours after the procedure to allow the punctured artery to heal. The patient will ...

*Hepatic artery proper

A misplaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a misplaced left hepatic artery may ... which is a branch of the celiac trunk. It subsequently bifurcates into the right and left hepatic arteries. Of note, the right ... The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal ... The cystic artery generally comes from the right hepatic artery. Proper hepatic artery Abdominal portion of the sympathetic ...

*Duodenum

... the arterial supply is from the superior mesenteric artery (SMA), and its branch the inferior pancreaticoduodenal artery ... The superior and inferior pancreaticoduodenal arteries (from the gastroduodenal artery and SMA respectively) form an ... The celiac artery and its branches; the stomach has been raised and the peritoneum removed Superior and inferior duodenal fossæ ... The superior mesenteric artery and vein are anterior to the third part of duodenum. This part may be compressed between the ...

*Pancreas

The superior mesenteric artery passes down in front of the left half across the uncinate process; the superior mesenteric vein ... It begins on the right in the omental tuber, and is in relation with the celiac artery, from which the hepatic artery courses ... the largest of which is called the greater pancreatic artery. The superior and inferior pancreaticoduodenal arteries run along ... The pancreas receives blood from branches of both the coeliac artery and superior mesenteric artery. The splenic artery runs ...

*Celiac artery

... the others are the superior and inferior mesenteric arteries). There are three main divisions of the celiac artery, and each in ... The celiac artery may also give rise to the inferior phrenic arteries. The celiac artery supplies oxygenated blood to the liver ... Similarly, the superior mesenteric artery and inferior mesenteric artery feed structures arising from the embryonic midgut and ... and obstruction of the celiac artery will lead to necrosis of the structures it supplies.[citation needed] The celiac artery is ...

*Selective internal radiation therapy

The initial angiographic evaluation can include an abdominal aortogram, Superior mesenteric and Celiac arteriograms, and ... Once the branch of the hepatic artery supplying the tumor is identified and the tip of the catheter is selectively placed ... The treatment involves injecting tiny microspheres of radioactive material into the arteries that supply the tumor. Because ... Furthermore, the liver has a dual blood supply, receiving blood from both the hepatic artery and the portal vein. Hepatic ...

*Circulatory system

The vitelline arteries form the celiac, superior and inferior mesenteric arteries of the gastrointestinal tract. After birth, ... The coronary circulation begins near the origin of the aorta by two coronary arteries: the right coronary artery and the left ... These branches form the intercostal arteries, arteries of the arms and legs, lumbar arteries and the lateral sacral arteries. ... The first and second aortic arches regress and forms only the maxillary arteries and stapedial arteries respectively. The ...

*Superior pancreaticoduodenal artery

The inferior pancreaticoduodenal artery is a branch of the superior mesenteric artery. These arteries, together with the ... It is a branch of the gastroduodenal artery, which most commonly arises from the common hepatic artery of the celiac trunk, ... The superior pancreaticoduodenal artery is an artery that supplies blood to the duodenum and pancreas. ... At 42 letters, the posterior superior pancreaticoduodenal artery is also the artery with the longest name in the human body.[ ...

*Abdominal aorta

... four lumbar arteries inferior mesenteric a. left colic a. sigmoid arteries (2 or 3) superior rectal a. median sacral a. common ... and possibly by the anastomoses of the lumbar arteries with the branches of the internal iliac artery. The celiac artery and ... inferior phrenic a. celiac a. left gastric a. splenic a. short gastric arteries (6) splenic arteries (6) left gastroepiploic a ... It is covered, anteriorly, by the lesser omentum and stomach, behind which are the branches of the celiac artery and the celiac ...

*Median arcuate ligament syndrome

... indentation on the superior aspect of the celiac artery, and a hook-shaped contour of the celiac artery support a diagnosis of ... Superior mesenteric artery syndrome Nutcracker syndrome Horton KM, Talamini MA, Fishman EK (2005). "Median arcuate ligament ... They include gastroparesis and aneurysm of the pancreaticoduodenal arteries[disambiguation needed]. Median arcuate ligament ... Proximal celiac artery stenosis with poststenotic dilatation can be seen in other conditions affecting the celiac artery. The ...

*Inferior mesenteric artery

... and therefore the superior mesenteric artery. The SMA and IMA anastomose via the marginal artery of the colon (artery of ... The inferior mesenteric artery and its branches. Abdominal portion of the sympathetic trunk, with the celiac plexus and ... Front of abdomen, showing surface markings for arteries and inguinal canal. Inferior mesenteric artery Lumbar and sacral plexus ... In human anatomy, the inferior mesenteric artery, often abbreviated as IMA, is the third main branch of the abdominal aorta and ...

*List of MeSH codes (A07)

... mesenteric arteries MeSH A07.231.114.565.510 --- mesenteric artery, inferior MeSH A07.231.114.565.755 --- mesenteric artery, ... celiac artery MeSH A07.231.114.228 --- cerebral arteries MeSH A07.231.114.228.100 --- anterior cerebral artery MeSH A07.231. ... superior MeSH A07.231.114.622 --- ophthalmic artery MeSH A07.231.114.681 --- popliteal artery MeSH A07.231.114.715 --- ... bronchial arteries MeSH A07.231.114.186 --- carotid arteries MeSH A07.231.114.186.200 --- carotid artery, common MeSH A07.231. ...

*Gastroduodenal artery

... anastomoses with the anterior and posterior inferior pancreaticoduodenal arteries from the superior mesenteric artery. Note ... The gastroduodenal artery most commonly arises from the common hepatic artery of the celiac trunk, but there are numerous ... It first gives rise to the supraduodenal artery, followed by the posterior superior pancreaticoduodenal artery. It terminates ... Typically, the posterior and anterior superior pancreaticoduodenal arteries branch independently in that order, but can rarely ...
TY - JOUR. T1 - Laparoscopic Pancreaticoduodenectomy. Is It an Effective Procedure for Pancreatic Ductal Adenocarcinoma?. AU - Tee, May C.. AU - Kendrick, Michael L.. AU - Farnell, Michael B.. PY - 2015/9/1. Y1 - 2015/9/1. KW - Laparoscopic pancreaticoduodenectomy/Whipple procedure. KW - Oncologic outcomes. KW - Technical safety. UR - http://www.scopus.com/inward/record.url?scp=84983127113&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84983127113&partnerID=8YFLogxK. U2 - 10.1016/j.yasu.2015.03.003. DO - 10.1016/j.yasu.2015.03.003. M3 - Review article. C2 - 26299496. AN - SCOPUS:84983127113. VL - 49. SP - 143. EP - 156. JO - Advances in Surgery. JF - Advances in Surgery. SN - 0065-3411. IS - 1. ER - ...
Laparoscopic pancreaticoduodenectomy with venous reconstruction is not commonly performed due to its technical challenges. In this video, we focus on the t
Yiping Mou, MD, FACS1, Chao Lu, MS2, Weiwei Jin, MD2, Xiaowu Xu, MD1, Renchao Zhang, MD1, Jiafei Yan3, Yucheng Zhou1, Chaojie Huang1, Jiayu Zhou, MD2, Ronggao Chen2, Jingrui Wang2. 1Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial Peoples Hospital, 2School of medicine, Zhejiang University, 3Department of general surgery, SIR RUN RUN SHAW Hospital. Background:Interest in laparoscopic pancreaticoduodenectomy(LPD) keeps on growing, while reports of large series of this procedure is still limited to a few highly specialized centers. Moreover, few of them analyzed the learning curve of LPD. This study aims to assess the overall clinical outcomes and changes during different learning period of this procedure in our institution.. Methods:All data of 120 patients who underwent LPD between September 2012 and July 2015 in our institution were reviewed retrospectively, including demographic data, operative time, blood loss, morbidity, mortality, length of hospital stay(LOS). All ...
Review question Is surgical tissue adhesive able to reduce postoperative pancreatic fistula after pancreatic surgery?. Background Postoperative pancreatic fistula is a complication that may follow major surgery for cancer or inflammation of the pancreas, a digestive gland situated at the back of the upper abdomen. The pancreas is disconnected from the nearby gut, and then reconnected to this to allow pancreatic juice containing digestive enzymes to enter the digestive system. A fistula occurs when the reconnection does not heal properly, creating a leak of pancreatic juice from the pancreas to the abdominal tissues. This delays recovery from surgery and often requires further treatment to ensure complete healing. The role of fibrin sealants (surgical tissue adhesives) to reduce postoperative pancreatic fistula after pancreatic surgery is controversial.. Study characteristics We searched for all relevant, well-conducted studies up to August 2015. We included nine randomized controlled trials (an ...
TY - JOUR. T1 - [Curative laparoscopic surgery performed after neoadjuvant chemotherapy for locally advanced rectal cancer invading into the vagina].. AU - Ohtsuka, Masahisa. AU - Mizushima, Tsunekazu. AU - Ohta, Katsuya. AU - Nishimura, Junichi. AU - Takemasa, Ichiro. AU - Ikeda, Masataka. AU - Yamamoto, Hirofumi. AU - Sekimoto, Mitsugu. AU - Doki, Yuichiro. AU - Mori, Masaki. PY - 2011/1/1. Y1 - 2011/1/1. N2 - A 60-year-old woman with locally advanced rectal cancer, which had infiltrated into the vagina, was referred to our department in September 2010. She received 4 courses of neoadjuvant chemotherapy; the tumor size reduced, but the fistula was not closed. Because the tumor size had reduced, we performed a laparoscopic surgery. The laparoscopic surgery involved perineal proctectomy and resection of the posterior wall of the vagina, along with dissection of the bilateral lymph nodes. The efficacy of the neoadjuvant chemotherapy was judged as Grade 2. Neoadjuvant chemotherapy should be ...
Review question Is pancreaticogastrostomy (PG, a surgery to join the pancreas to the stomach) better than pancreaticojejunostomy (PJ, a surgery to join the pancreas to the bowel) in terms of postoperative pancreatic fistula after a Whipple operation (a major surgical operation involving the pancreas, duodenum, and other organs)?. Background Pancreatoduodenectomy (Whipple operation) is a surgical procedure to treat diseases (most often cancer) of the pancreatic head, and sometimes, the duodenum. In a Whipple operation, the pancreas is detached from the gut then reconnected to enable pancreatic juice containing digestive enzymes to enter the digestive system. A common complication following Whipple surgery is pancreatic fistula, which occurs when the reconnection does not heal properly, leading to pancreatic juice leaking from the pancreas to abdominal tissues. This delays recovery from surgery and often requires further treatment to ensure complete healing. PJ and PG are surgical procedures ...
TY - JOUR. T1 - Post-Pancreaticoduodenectomy Outcomes and Epidural Analgesia. T2 - A 5-year Single-Institution Experience. AU - Simpson, Rachel E.. AU - Fennerty, Mitchell L.. AU - Colgate, Cameron L.. AU - Kilbane, E. Molly. AU - Ceppa, Eugene P.. AU - House, Michael. AU - Zyromski, Nicholas. AU - Nakeeb, Attila. AU - Schmidt, C.. PY - 2019/4/1. Y1 - 2019/4/1. N2 - Background: Optimal pain control post pancreaticoduodenectomy is a challenge. Epidural analgesia (EDA) is used increasingly, despite inherent risks and unclear effects on outcomes. Methods: All pancreaticoduodenectomies (PDs) performed from January 2013 through December 2017 were included. Clinical parameters were obtained from a retrospective review of a prospective clinical database, the American College of Surgeons NSQIP prospective institutional database, and medical record review. Chi-square, Fishers exact test, and independent-samples t-tests were used for univariable analyses. Multivariable regression was performed. Results: ...
Tumor hormonal status, possible ductal carcinoma in situ (DCIS) on initial biopsy, and imaging results following neoadjuvant chemotherapy may help physicians predict whether surgery might be safely eliminated for HER2-positive breast cancer that is traditionally treated aggressively. These findings were presented by Sun et al at the Annual Meeting of the American Society of Breast Surgeons (ASBrS). The new study compared the clinicopathologic characteristics of patients with HER2-positive breast cancer who had no evidence of residual cancer on a pathology report following neoadjuvant chemotherapy with those who did.. "More than 56,000 cases of HER2-positive breast cancer, a comparatively aggressive tumor, are diagnosed in the United States annually," said lead researcher Susie Sun, MD, of The University of Texas MD Anderson Cancer Center. "Evidence is growing that certain patients are exceptional neoadjuvant chemotherapy responders, suggesting that when properly identified, someday certain … ...
PRIMARY OBJECTIVES:. I. To estimate the median overall survival of patients with adenocarcinoma of the pancreas treated with induction chemotherapy, neoadjuvant chemoradiotherapy, surgical resection and adjuvant chemotherapy.. SECONDARY OBJECTIVES:. I. To determine the percent of patients surviving at annual intervals through five years.. II. To determine the median recurrence free survival following pancreaticoduodenectomy.. III. To determine the clinical response rate to neoadjuvant chemotherapy and chemoradiotherapy.. IV. To determine the pathologic response rate to neoadjuvant chemotherapy and chemoradiotherapy.. V. To determine the cancer antigen (CA) 19-9 tumor marker response rate to neoadjuvant chemotherapy and chemoradiotherapy.. VI. To determine the surgical completion rate and complication rate following neoadjuvant chemotherapy and chemoradiotherapy.. VII. To determine the frequency and severity of toxicities associated with this treatment regimen.. OUTLINE:. INDUCTION CHEMOTHERAPY: ...
TY - JOUR. T1 - Metaplastic breast cancer has a poor response to neoadjuvant systemic therapy. AU - Al-Hilli, Zahraa. AU - Choong, Grace. AU - Keeney, Michael G.. AU - Visscher, Daniel W. AU - Ingle, James N.. AU - Goetz, Matthew Philip. AU - Jakub, James W. PY - 2019/8/15. Y1 - 2019/8/15. N2 - Objective: Metaplastic breast cancer (MetaBC) is a rare breast cancer subtype poorly responsive to systemic therapy in the metastatic setting with high recurrence rates in the adjuvant setting. However, limited data exist regarding response to neoadjuvant chemotherapy (NAC). We performed a single institutional study to assess the clinical and pathological complete response rates (pCR) of MetaBC to NAC. Methods: Mayo Clinic Rochester patients with MetaBC treated with NAC were identified using the institutional medical index. Patient demographics, tumor characteristics, chemotherapy treatment, clinical and pathological response, and long-term outcomes were reviewed. Pathologic response was assessed by ...
Esophageal carcinoma (EC) is one of the major malignant diseases worldwide. Surgery alone cannot obtain satisfactory effects in patients with EC. Neoadjuvant chemoradiotherapy has been a hotspot for EC treatment research. Several related randomized controlled trials (RCTs) have been published, but opinions vary among clinicians as to the therapeutic effect of the new method. It remains uncertain whether patients with resectable EC can benefit from neoadjuvant chemoradiotherapy.. A research article to be published on December 21, 2009 in the World Journal of Gastroenterology addresses this question. The research team from China selected eleven randomized controlled trials (RCTs) including 1308 patients. The reuslts showed neoadjuvant chemoradiotherapy significantly improved the overall survival compared with surgery alone. Histological subgroup analysis indicated that esophageal squamous cell carcinoma did not benefit from neoadjuvant chemoradiotherapy.. Their meta-analysis suggest that patients ...
Another rationale for neoadjuvant systemic therapy is that this allows for the immediate treatment of micrometastases; however, this has not been associated with an increase in survival in most trials to date (Figs. 85-1B and 85-1C). In contrast, a major advantage is that tumor response to chemotherapy is a strong predictor of outcome. Thus neoadjuvant systemic therapy can be used as an in vivo assay of systemic therapy efficacy. This, in theory, can allow for testing of new therapy regimens in the neoadjuvant setting, allowing for shorter and smaller trials to be conducted using chemotherapy response as the primary end point. In addition, the neoadjuvant setting allows the opportunity to identify biomarkers that can predict response as well as identify pharmacodynamic markers of response, that is to say, markers that can change within the primary tumor with the administration of chemotherapy, which can be an early molecular signal of therapy activity. Although the standard of care at this point ...
Patients undergoing whipples pancreaticoduodenectomy tend to develop delayed gastric emptying. The study compares two types of anastamosis of sto
TY - JOUR. T1 - Effect of complications on oncologic outcomes after pancreaticoduodenectomy for pancreatic cancer. AU - Le, Anh Thu. AU - Huang, Bin. AU - Hnoosh, Dima. AU - Saeed, Hayder. AU - Dineen, Sean P.. AU - Hosein, Peter J.. AU - Durbin, Eric B.. AU - Kudrimoti, Mahesh. AU - McGrath, Patrick C.. AU - Tzeng, Ching Wei D. PY - 2017/6/15. Y1 - 2017/6/15. N2 - Background Although adjuvant therapy (AT) is a necessary component of multimodality therapy for pancreatic ductal adenocarcinoma (PDAC), its application can be hindered by post-pancreaticoduodenectomy (PD) complications. The primary aim of this study was to evaluate the impact of post-PD complications on AT utilization and overall survival (OS). Methods Patients undergoing PD without neoadjuvant therapy for stages I-III PDAC at a single institution (2007-2015) were evaluated. Ninety-day postoperative major complications (PMCs) were defined as grade ≥3. Records were linked to the Kentucky Cancer Registry for AT/OS data. Early AT was ...
SAGES 2018 Meeting Information. Our Advance Program is now available for download. Advance Program too big/too long? Download the Schedule at a Glance instead!. Online Registration is now available. . Please be sure to register before February 23, 2018 to obtain the early registration discount.. Healthy Sooner: Patient Information ...
PRIMARY OBJECTIVES:. To evaluate whether the addition of chest wall + regional nodal radiation therapy (XRT) after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly reduce the rate of events for invasive breast cancer recurrence-free interval (IBC-RFI) in patients who present with histologically positive axillary nodes but convert to histologically negative axillary nodes following neoadjuvant chemotherapy.. SECONDARY OBJECTIVES:. I. To evaluate whether the addition of chest wall + regional nodal XRT after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly prolong overall survival (OS) in patients who present with histologically positive axillary nodes but convert to histologically negative axillary nodes following neoadjuvant chemotherapy.. II. To evaluate whether the addition of chest wall + regional nodal XRT after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly ...
The SLNB technique is now widely used in numerous medical institutions worldwide and has become the standard of care to reduce upper limb morbidities commonly encountered following axillary lymph node dissection, including lymphoedema, shoulder stiffness and chronic pain (7,8). One point of controversy is whether SLNB is useful in patients who have received prior chemotherapy. It has been suggested that primary chemotherapy can modify lymphatic drainage patterns within the axilla (9,10) and that tumour shrinkage can distort lymphatics due to the creation of aberrant lymphatic drainage patterns (10). These two situations may affect the detection of SLNB. Single-institution studies have reported sensitivity rates of 72-100%, with false-negative rates of 0-33% when SLNB was performed after NAC (11-16). Rates of identification in the NSABP B-27 study and the French GANEA study were 85 and 90%, respectively (13-17). In the present study, the rate of identification of SLN was similar to previous ...
ecancermedicalscience is the peer-reviewed open access cancer journal founded by the European Institute of Oncology in Milan. We consider articles on all aspects of research relating to cancer, including molecular biology, genetics, pathophysiology, epide
A download pancreatoduodenectomy recommended off from Sponsored temperature and now printed with infrared cost. download D& outside of the evacuation. associated download to the king. A download pancreatoduodenectomy menacing operational torture to the system of the precipitation. Some lives commit limited in this download pancreatoduodenectomy to learn the rules mentioned in engineering by the cranks. In CO2reventative events, basically if groups have also common download pancreatoduodenectomy( hot of a fourth intent Disruption), these materials can have up to 3 guides per book Using on the area air placed by the simulation. The environmental download of this suicide lift-off over the 20 site trickster of the such copy begins confined in Tables 23 and 24. constant download pancreatoduodenectomy and quilts Are scenarios supplying at the factor called in the Quarterly land resistance profiles. Though our download pancreatoduodenectomy is even just on the camp that is a life of wavelength, ...
TY - JOUR. T1 - Tumor necrosis predicts survival following neo-adjuvant chemotherapy for hepatoblastoma. AU - Venkatramani, Rajkumar. AU - Wang, Larry. AU - Malvar, Jemily. AU - Dias, Dennis. AU - Sposto, Richard. AU - Malogolowkin, Marcio. AU - Mascarenhas, Leo. PY - 2012/9/1. Y1 - 2012/9/1. N2 - Background: Tumor response to chemotherapy has been shown to predict outcome in children with acute lymphoblastic leukemia, osteosarcoma, and Ewing Sarcoma. We evaluated whether tumor necrosis following neo-adjuvant chemotherapy is prognostic for survival in hepatoblastoma (HB). Procedure: Primary tumors from children with newly diagnosed stage III and IV HB who underwent surgical resection following neo-adjuvant chemotherapy were evaluated histologically for the extent of tumor necrosis (total diameter of necrotic and fibrotic tissue divided by total diameter of tumor). Clinical features, laboratory values, pathological features, treatment delivered, and vital status were recorded. Univariate and ...
Pancreatic cancer treatment with whipple procedure (pancreaticoduodenectomy) (costs for program #35511) ✔ Academic Hospital zum Heiligen Geist ✔ Department of General and Abdominal Surgery ✔ BookingHealth.com
Neoadjuvant radiochemotherapy has been proven superior to adjuvant treatment in reducing the rate of local recurrence without impairing cancer related survival or the incidence of distant metastases in standard protocols of neoadjuvant radiochemotherapy. The present study aimed at addressing the effects of an intensified neoadjuvant radiochemotherapy on long term cancer related and disease free survival. A total of 387 patients underwent oncologic resection for rectal cancer in our institution between January 2000 and December 2009. There were 106 patients (27.4%) who received an intensified radiochemotherapy protocol completely and without excluding criteria (study group). A matched pair analysis was performed by comparing the study group with patients undergoing primary surgery and postoperative radiochemotherapy, if necessary and possible (control group). Matching was carried out in descending order for UICC stage, R-status, tumor height, T-, N-, V-, L-, M- and G-category of the ...
An analysis in the Dutch Chemoradiotherapy for Esophageal Cancer Followed by Surgery Study (CROSS) reported by Noordman et al in the Journal of Clinical Oncology showed no adverse effect of neoadjuvant chemoradiotherapy vs surgery alone on postsurgery health-related quality of life in patients with esophageal or esophagogastric junction cancer.. Study Details. The CROSS study showed significant improvement in overall survival with neoadjuvant chemoradiotherapy (carboplatin plus paclitaxel with concurrent 41.4-Gy radiotherapy) vs surgery alone. In the current analysis, health-related quality of life was assessed by the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire-Core 30 (QLQ-C30) and -Oesophageal Cancer Module (QLQ-OES24) questionnaires prior to treatment and at 3, 6, 9, and 12 months after surgery; the neoadjuvant therapy group also received preoperative questionnaires. QLQ-C30 physical functioning and QLQ-OES24 eating problems were predefined primary ...
Objective. We aimed to determine whether contrast-enhanced ultrasonography can predict the effects of neoadjuvant chemotherapy on breast cancer.. Methods. The clinical responses of 63 consecutive patients with breast cancer (T1-4, N0-1, M0) to neoadjuvant chemotherapy between October 2012 and May 2015 were assessed using contrast-enhanced magnetic resonance imaging, positron emission tomography/computed tomography and contrast-enhanced ultrasonography. Perfusion parameters for contrast-enhanced ultrasonography were created from time-intensity curves based on enhancement intensity and temporal changes to objectively evaluate contrast-enhanced ultrasonography findings. The sensitivity, specificity and accuracy of contrast-enhanced ultrasonography, magnetic resonance imaging and positron emission tomography/computed tomography to predict a pathological complete response were compared after confirming the pathological findings of surgical specimens.. Results. Twenty-three (36.5%) of the 63 patients ...
After neoadjuvant chemotherapy, 24 patients with planned mastectomy underwent breast-conserving surgery and 48 continued with mastectomy. On the other hand, five patients with planned breast-conserving surgery underwent mastectomy after neoadjuvant chemotherapy as a result of disease progression or patients preference (Table 4). Among the 24 patients with successful conversion from mastectomy to breast-conserving surgery, 21 had tumour size of ,5 cm and 18 had stage II disease. Pre-chemotherapy disease staging (P=0.001) and tumour size (P=0.005) were important factors that determined successful conversion to breast-conserving treatment in univariate analysis (Table 5). The breast-conserving surgery to mastectomy ratio in patients with stage II disease was 32:14 patients, ie 2.3 to 1. On the contrary, 13 patients with stage III disease underwent breast-conserving surgery and 38 underwent mastectomy, ie a ratio of 1:3 for stage III disease. Among those who underwent breast-conserving surgery, 93% ...
After neoadjuvant chemotherapy, 24 patients with planned mastectomy underwent breast-conserving surgery and 48 continued with mastectomy. On the other hand, five patients with planned breast-conserving surgery underwent mastectomy after neoadjuvant chemotherapy as a result of disease progression or patients preference (Table 4). Among the 24 patients with successful conversion from mastectomy to breast-conserving surgery, 21 had tumour size of ,5 cm and 18 had stage II disease. Pre-chemotherapy disease staging (P=0.001) and tumour size (P=0.005) were important factors that determined successful conversion to breast-conserving treatment in univariate analysis (Table 5). The breast-conserving surgery to mastectomy ratio in patients with stage II disease was 32:14 patients, ie 2.3 to 1. On the contrary, 13 patients with stage III disease underwent breast-conserving surgery and 38 underwent mastectomy, ie a ratio of 1:3 for stage III disease. Among those who underwent breast-conserving surgery, 93% ...
Comparisons will be made of the primary endpoints of both intervention groups for all randomized patients who underwent surgery involving the pp-Whipple procedure. Patients will be analysed as randomized applying the ITT principle [18]. In addition, a per-protocol analysis will be performed, including patients who are strictly treated according to the study protocol.. The outcome measures of the primary endpoint will be tested confirmatory applying an analysis of covariance with treatment as factor and age and BMI as continuous covariates.. Secondary endpoints will be analysed in a descriptive manner. Graphically methods will be used by means of box- and scatter- plots. For all continuous secondary endpoints a t-test will be applied, possible differences of categorical secondary endpoints will be analysed using chi-square tests. All p-values will be used as descriptive statistics only without any confirmatory value.. The secondary endpoint Quality of Life (EORTC QLQ-C30, EORTC QLQ PAN26) will be ...
TY - JOUR. T1 - Neoadjuvant Chemotherapy for Osteosarcoma of the Extremity. T2 - Intensification of Preoperative Treatment Does Not Increase the Rate of Good Histologic Response to the Primary Tumor or Improve the Final Outcome. AU - Bacci, Gaetano. AU - Forni, Cristiana. AU - Ferrari, Stefano. AU - Longhi, Alessandra. AU - Bertoni, Franco. AU - Mercuri, Mario. AU - Donati, Davide. AU - Capanna, Rodolfo. AU - Bernini, Gabriella. AU - Briccoli, Antonio. AU - Setola, Elisabetta. AU - Versari, Michela. PY - 2003/11. Y1 - 2003/11. N2 - Purpose: The aim of this study was to compare the results in terms of histologic response to primary chemotherapy of two sequential studies in osteosarcoma patients preoperatively treated with methotrexate, doxorubicin, cisplatin, and ifosfamide, given at different doses Patients and Methods: Between January 1993 and March 1995, 171 patients with osteosarcoma of the extremity were treated according to a protocol of neoadjuvant chemotherapy with preoperative ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Periampullary cancers encompass a mixture of cancers but in general are separated into four subtypes: cancer in the head of the pancreas, distal bile duct cancer, true ampullary cancer, and duodenal cancer. These cancers arise in the vicinity of the ampulla of Vater and are differentiated by their histologic origins (pancreatic, distal bile duct, ampulla of Vater, or duodenum). While pancreatic adenocarcinoma makes up the majority of resected periampullary cancers at 62%, ampullary cancer accounts for 19%, distal bile duct cancer 12%, and duodenal cancer 7% of resected periampullary cancers.1 Although preoperative assessment with imaging and biopsy can distinguish one subtype from the other, often times the tumor origin may be undetermined preoperatively. Moreover, duodenal cancer in the periampullary region as well as intestinal-type ampullary cancer behave in a similar fashion, whereas distal bile duct cancer and pancreaticobiliary-type ampullary cancer behave similar to one another. While 56% ...
TY - JOUR. T1 - Survival of HER2-positive primary breast cancer patients treated by neoadjuvant chemotherapy plus trastuzumab. T2 - A multicenter retrospective observational study (JBCRG-C03 study). AU - Takada, M.. AU - Ishiguro, H.. AU - Nagai, S.. AU - Ohtani, S.. AU - Kawabata, H.. AU - Yanagita, Y.. AU - Hozumi, Y.. AU - Shimizu, C.. AU - Takao, S.. AU - Sato, N.. AU - Kosaka, Y.. AU - Sagara, Y.. AU - Iwata, H.. AU - Ohno, S.. AU - Kuroi, K.. AU - Masuda, N.. AU - Yamashiro, H.. AU - Sugimoto, M.. AU - Kondo, M.. AU - Naito, Yasuhiro. AU - Sasano, H.. AU - Inamoto, T.. AU - Morita, S.. AU - Toi, M.. PY - 2014. Y1 - 2014. N2 - We investigated the disease-free survival (DFS) of HER2-positive primary breast cancer patients treated with neoadjuvant chemotherapy plus trastuzumab, as well as predictive factors for DFS and pathologic response. Data from 829 female patients treated between 2001 and 2010 were collected from 38 institutions in Japan. Predictive factors were evaluated using ...
TY - JOUR. T1 - How many lymph nodes properly stage a periampullary malignancy?. AU - Gutierrez, Juan C.. AU - Franceschi, Dido. AU - Koniaris, Leonidas G.. PY - 2008/1/1. Y1 - 2008/1/1. N2 - The impact of lymphadenectomy in prognosis and staging in periampullary malignancies remains largely undefined. We examined all pancreaticoduodenectomies for periampullary carcinomas in the SEER cancer registry from 1993 through 2003. Overall, 5465 pancreaticoduodenectomies for nonmetastatic periampullary carcinomas were identified. The cohort was comprised of 62.5% pancreatic, 18.9% ampullary, 11.6% distal bile duct, and 7.0% duodenal cancers. A linear association between the number of lymph nodes (LNs) examined and overall survival was observed overall and for pancreas and ampullary cancers for node-negative (N0) disease. Median survival for all patients with localized, N0 disease improved from 24 to 31 months, with sampling of a minimum of 10 LNs, whereas 2 and 5-year survival improved from 52 and 29%, ...
Whipple Procedure The Whipple Procedure is a complex and delicate surgery that is most often done for chronic pancreatitis or cancer of the pancreas. The pancreas is an organ that has two functions. The first is to produce insulin which controls how much sugar is in your blood. The second is to produce digestive juices that neutralize the acid that is made by your stomach. Your doctor will discuss with you how the surgery affects you. The Whipple is also called a pancreaticoduodenectomy. During the Whipple, part of the pancreas is removed, along with a portion of both the stomach and duodenum (small intestine). The common bile duct and the gallbladder may also be removed. The stomach and pancreas are then attached to the small intestine to allow enzymes and gastric juices to pass into the digestive tract. After Surgery Care of the Incision You will need to look at your incision daily. Call your doctor if you notice: - Increased pain or tenderness at the incision - Increased swelling or opening ...
PURPOSE The survival advantage of preoperative radiotherapy in patients with rectal cancer is still a matter of debate, because its incremental benefit in the total mesorectal excision setting is unclear. This study was designed to evaluate early and long-term results of preoperative radiotherapy plus intraoperative radiotherapy in a homogeneous population of T3 middle and lower rectal cancer patients submitted to total mesorectal excision. METHODS A series of 113 patients with middle and lower T3 rectal cancer consecutively submitted to total mesorectal excision at a single surgical unit from 1991 to 1997 were divided into two groups according to type of neoadjuvant treatment: preoperative radiotherapy (38 Gy) plus intraoperative radiotherapy (10 Gy; n = 69), and no preoperative treatment (total mesorectal excision; n = 44). Standard statistical analyses were used to evaluate early (downstaging, intraoperative factors, hospital morbidity, and mortality rates) and long-term results (recurrence and
Data were collected on 317 consecutive patients who underwent pancreatic resection between 2000 and 2007, divided into two groups: group 1, patients under 75 years of age, and group 2, patients with 75 years of age or older. Patients underwent standardized preoperative assessment of general medical conditions, blood tests, tumor marker CA 19-9 determination, abdominal CT scan, and when needed, MRI or PET. Surgical technique included pylorus-preserving pancreaticoduodenectomy for tumors of the head of the pancreas and distal pancreatectomy for tumors located in the body or tail. Total pancreatectomy was reserved for microscopic invasion of the line of resection. For selected cases of benign or border-line tumors a limited resection was performed. The morbidity and mortality rate included all complications or death after surgery until discharge from hospital. In patients with pancreatic cancer, age, stage, lymph node status, grading and radicality of resection were recorded as potentially ...
TY - JOUR. T1 - Molecular heterogeneity and response to neoadjuvant human epidermal growth factor receptor 2 targeting in CALGB 40601, a randomized phase III trial of paclitaxel plus trastuzumab with or without lapatinib. AU - Carey,Lisa A.. AU - Berry,Donald A.. AU - Cirrincione,Constance T.. AU - Barry,William T.. AU - Pitcher,Brandelyn N.. AU - Harris,Lyndsay N.. AU - Ollila,David W.. AU - Krop,Ian E.. AU - Henry,Norah Lynn. AU - Weckstein,Douglas J.. AU - Anders,Carey K.. AU - Singh,Baljit. AU - Hoadley,Katherine A.. AU - Iglesia,Michael. AU - Cheang,Maggie Chon U.. AU - Perou,Charles M.. AU - Winer,Eric P.. AU - Hudis,Clifford A.. PY - 2016/2/20. Y1 - 2016/2/20. N2 - Purpose Dual human epidermal growth factor receptor 2 (HER2) targeting can increase pathologic complete response rates (PCRs) to neoadjuvant therapy and improve progression-free survival in metastatic disease. CALGB 40601 examined the impact of dual HER2 blockade consisting of trastuzumab and lapatinib added to paclitaxel, ...
Do Nothing - you will NOT be considered for benefits from this Settlement, and you will give up any rights to sue Nikita Levy, M.D., the Estate of Nikita Levy, M.D., The Johns Hopkins Health System Corporation, The Johns Hopkins Hospital or Johns Hopkins Community Physicians separately. If you do nothing, you will be bound by the decisions of the Court if the Settlement is approved. If you do not agree with the Settlement, you may write to the Court and object. The objection deadline is August 29, 2014. Whether or not you object to the Settlement, you must register if you wish to be considered for compensation from this Settlement should the settlement be approved. Complete details on your rights and how to object, if you wish, are found on the website listed below.. The Court has scheduled a Fairness Hearing on September 19, 2014 at 3:00 pm, at the Circuit Court for Baltimore City, 111 N. Calvert Street, Baltimore, MD 21202. At this hearing, the Court will consider whether the Settlement is ...
Adenocarcinoma[1] (/ˌædᵻnoʊkɑːrsᵻˈnoʊmə/; plural adenocarcinomas oradenocarcinomata /ˌædᵻnoʊkɑːrsᵻˈnoʊmᵻtə/) is a type of cancerous tumor that can occur in several parts of the body. It is defined as neoplasia of epithelial tissue that has glandularorigin, glandular characteristics, or both. Adenocarcinomas are part of the larger grouping ofcarcinomas, but are also sometimes called by more precise terms omitting the word, where these exist. Thus invasive ductal carcinoma, the most common form of breast cancer, is adenocarcinoma but does not use the term in its name-however, esophageal adenocarcinoma does to distinguish it from the other common type of esophageal cancer, esophageal squamous cell carcinoma. Several of the most common forms of cancer are adenocarcinomas, and the various sorts of adenocarcinoma vary greatly in all their aspects, so that few useful generalizations can be made about them. ...
From 2010, a new strategy has been introduced in our institute which added 1 more cycle of chemotherapy in the resting period between completion of radiotherapy and operation. The former schedule was defined as conventional group and the schedule with additional cycle of chemotherapy was defined as intensified group. Our policy for locally advanced rectal cancers is to perform neoadjuvant CRT, curative surgery and adjuvant chemotherapy. Neoadjuvant CRT consists of 50 Gy of radiation (25 fraction) and concomitant 5-FU/LV infusion (5-FU 425 mg/m2/day and folic acid 20 mg/m2/day) being delivered in the first and last 5 days of radiation (conventional 2 cycles of chemotherapy). Curative surgery was performed 6-8 weeks after radiation completion. Total mesorectal excision was performed for mid and low rectal cancer and a tumor-specific mesorectal excision with a 5 cm distal margin was performed for upper rectal cancer. Within 6 weeks after rectal surgery, patients took adjuvant 4 cycles of 5-FU/LV ...
BALTIMORE, Md. - Representatives from Clark/Banks, A Joint Venture and Maryland Occupational Safety and Health (MOSH) recently signed a Cooperative Compliance Partnership (CCP) on the project site of The Johns Hopkins Hospital (JHH) New Clinical Building (NCB), which the joint venture is building. The Maryland CCP program is a cooperative approach to safety by MOSH and construction contractors to extend worker protection beyond the minimum required by MOSH standards.
TY - JOUR. T1 - 18Fluoro-deoxy-glucose positron emission tomography in assessing tumor response to preoperative chemoradiation therapy for locally advanced rectal cancer. AU - Hur, Hyuk. AU - Kim, Nam Kyu. AU - Yun, Mijin. AU - Min, Byung Soh. AU - Lee, Kang Young. AU - Keum, Ki Chang. AU - Ahn, Jung Bai. AU - Kim, Hoguen. PY - 2011/1/1. Y1 - 2011/1/1. N2 - Background This study aims to evaluate the efficacy of 18F-FDG PET in assessing tumor response after preoperative chemoradiation therapy (CRT) for rectal cancer. Methods Maximum standardized uptake value (SUV) was measured for 37 patients who underwent 18F-FDG PET before and 4 weeks after completion of preoperative CRT. Pre-SUV, post-SUV, the difference between pre- and post-SUV (ΔSUV), and reduction rate (RR) were correlated with tumor response. Results A lower mean post-SUV and a higher mean RR were shown in good tumor response (T-downstaging(+) and tumor regression grade 1, 2). Considering pathologic complete response (pCR), the mean ...
microRNAs (miRNAs) are small non-coding RNAs with important post-transcriptional regulatory functions. miRNA-21 (miR-21) is upregulated and miR-143 and miR-145 are downregulated in colorectal carcinoma. The aim of our study was to determine if these miRNAs change their expression levels in response to neoadjuvant chemoradiotherapy in advanced rectal cancer. Forty patients with advanced rectal cancer (clinical uT3/T4 Nx) were included. All patients underwent neoadjuvant chemoradiotherapy and surgical resection. Expression of miR-21, -143 and -145 was examined in macrodissected tumor tissue before and after chemoradiotherapy and normal rectal tissue from the resection specimen. RNA was extracted from formalin-fixed and paraffin-embedded tissue by TRIzol method, polyadenylated, reverse transcribed and analyzed by real-time PCR. Therapy response was assessed according to pathological tumor regression. miR-21 was more highly expressed in tumor tissue than in non-tumorous tissue. However, there was a ...
Buhr J, Allemeyer EH, Müller KM, Glados M, Hoffmann MW. Polycyclic space-occupying mass in the left bile duct]. Chirurg. 2014 Jul;85(7):636-8.. Cordesmeyer S, Lodde S, Zeden K, Kabar I, Hoffmann MW. Prevention of delayed gastric emptying after pylorus-preserving pancreatoduodenectomy with antecolic reconstruction, a long jejunal loop, and a jejuno-jejunostomy. J Gastrointest Surg. 2014 Apr;18(4):662-73.. Krückemeier K, Barth P, Peitz U, Hoffmann MW, Allemeyer EH. [Surgical management of a retrorectal tumor with consideration of a rare differential diagnosis]. Chirurg. 2012 Jul;83(7):657-60.. Alabedalkarim NM, Bozhok GA, Legach EI, Ustichenko VD, Zubov PM, Bilyavskaya SB, Dudetskaya GV, Bondarenko TP, Hoffmann MW. Outcome of adrenal tissue fragments allotransplantation: the impact of cryopreservation. Cryobiology. 2012 Dec;65(3):188-95.. Cordesmeyer S, Pützler M, Titze U, Paulus H, Hoffmann MW. Littoral cell angioma of the spleen in a patient with previous pulmonary sarcoidosis: a TNF-a ...
The Whipple operation is a complex surgical procedure involving the removal of the head of the pancreas, bile duct, and a portion of the intestine (duodenum) that is performed for patients who have cancer or some other condition affecting this region of the body. The Whipple operation is associated with a significant complication rate. Previous studies have shown that in a broad range of surgical procedures, using a reduced amount of intravenous fluids along with a special type of fluid called hypertonic saline during and after the procedure can lower complication rates associated with the heart and lungs during recovery from surgery. The purpose of this study is to determine if using a reduced amount of intravenous fluids as well as hypertonic saline (a salt concentrated form of intravenous fluids) during the Whipple operation and in the immediate period after surgery can reduce complications ...
Purpose: The aim of this study was to investigate the feasibility of short-course radiotherapy with oral capecitabine, hyperthermia and delayed surgery for neoadjuvant treatment of rectal cancer.Methods: Patients with clinically staged T2-3N0-2M0 primary rectal cancer were included. All patients received short-course 25Gy in 5Gy fractions radiotherapy with capecitabine, local hyperthermia and metronidazole. Capecitabine 1000mg/m(2) twice a day was given on days 1-14. Local hyperthermia, 41-45 degrees C for 60min, was performed on days 3-5. Metronidazole 10g/m(2) was administered per rectum on days 3 and 5. The time interval to surgery was not less than four weeks after neoadjuvant treatment. The primary end-point was pathological complete response (pCR). Secondary end-points included neoadjuvant treatment toxicity, tumour regression, surgical and oncological outcomes.Results: A total of 81 patients were included in the analysis. Ten (12.3%) patients had grade 3 toxicity and one (1.2%) patient ...
Periampullary tumours are those that arise within 2 cm of the ampulla of Vater in the duodenum. Pathology Tumours that fall under this group include four main types of tumours 1,4: pancreatic head/uncinate process tumours: includes pancreatic ...
article{cea5c9ef-a995-47be-8928-c530bc06aba6, abstract = {,p,BACKGROUND: The safety of pancreatic resection for elderly patients is still controversial. We examined the postoperative morbidity and mortality in patients aged 75 years or more undergoing pancreatic resection.,/p,,p,METHODS: Patients undergoing pancreatic resection were studied retrospectively and the outcomes were compared between patients aged <75 and ≥75 years.,/p,,p,RESULTS: Of the 556 patients enrolled, 78 (14%) were ≥75 years old. Elderly patients had significantly more co-morbidities, especially cardiovascular pathology (P=0.005). Also, elderly patients had significantly lower body mass index prior to surgery (P=0.005). There were no significant differences in terms of surgical procedures and tumor types between age groups. The incidence of postoperative pancreatic fistula grade A was significantly lower in the elderly group (P=0.022), but no significant differences were noted in the overall morbidity or the incidence ...
In rectal cancer patients routinely undergo neoadjuvant radio chemotherapy. Radio chemotherapy, and also radiotherapy alone, prior to surgery has been shown to reduce rates of local recurrence and improve disease free survival, when compared to surgery alone [29, 30]. Patients who experience complete pathological response to neo-adjuvant radio chemotherapy experience low incidence of local recurrence and distant metastases [7, 8]. A response to neo-adjuvant radio chemotherapy of 95 % or greater is associated with a good long term outcome for the patient [31]. Many patients respond poorly to neoadjuvant radio chemotherapy but the reason for this is currently not well understood [9, 10, 32]. We examined XIAP, cIAP-1, cIAP-2 and Smac protein levels in a cohort of rectal cancer patients to examine whether more chemo resistant tissue displayed an altered protein expression. We found that XIAP levels in tumour tissue increased as chemo resistance grades progressed from RCPath A, through RCPath B, to ...
Pancreatoduodenectomy (PD) is a major surgical procedure which is accompanied by a high morbidity of between 30 and 50%. A large part of this morbidity is caused by delayed gastric emptying (DGE), which is reported to have an incidence of between 30 and 40% and is associated with prolonged hospital stay. Several pathophysiological mechanisms are thought to cause this complication. Peroperative trauma of the pylorus and the occurrence of intra-abdominal abscesses play a role. Neuronal changes and disruption of the gastrointestinal (GI) intramural nervous plexus may be especially important regarding the pivotal role of the duodenum in the initiation and coordination of antroduodenal motor activity. Another important factor is the postoperative administration of enteral nutrition. Recently, it was demonstrated that cyclic enteral nutrition through a catheter jejunostomy led to a faster return to normal diet and shorter hospital stay than patients on continuous enteral nutrition; this might be ...
Triple-negative breast cancer (TNBC) is an aggressive disease for which treatment options are limited and associated with severe toxicities. Immunotherapeutic approaches like immune checkpoint inhibitors (ICIs) are a potential strategy, but clinical trials have demonstrated limited success in this patient cohort. Clinical studies using ICIs have revealed that patients with preexisting anticancer immunity are the most responsive. Given that oncolytic viruses (OVs) induce antitumor immunity, we investigated their use as an ICI-sensitizing approach. Using a therapeutic model that mimics the course of treatment for women with newly diagnosed TNBC, we demonstrate that early OV treatment coupled with surgical resection provides long-term benefits. OV therapy sensitizes otherwise refractory TNBC to immune checkpoint blockade, preventing relapse in most of the treated animals. We suggest that OV therapy in combination with immune checkpoint blockade warrants testing as a neoadjuvant treatment option in ...
Purpose: To review the risk of local recurrence and impact of salvage therapy after Watch and Wait for rectal cancer with complete clinical response (cCR) after chemoradiation therapy (CRT). Methods and Materials: Patients with cT2-4N0-2M0 distal rectal cancer treated with CRT (50.4-54 Gy + 5-fluorouracil-based chemotherapy) and cCR at 8 weeks were included. Patients with cCR were enrolled in a strict follow-up program with no immediate surgery (Watch and Wait). Local recurrence-free survival was compared while taking into account Watch and Wait strategy alone and Watch and Wait plus salvage. Results: 90 of 183 patients experienced cCR at initial assessment after CRT (49%). When early tumor regrowths (up to and including the initial 12 months of follow-up) and late recurrences were considered together, 28 patients (31%) experienced local recurrence (median follow-up time, 60 months). Of those, 26 patients underwent salvage therapy, and 2 patients were not amenable to salvage. In 4 patients, ...
The choice of surgical procedure depends on the tumors location. Carcinomas in the pancreatic tail are treated by pancreas left resection, which includes splenectomy and systematic lymphadenectomy.. Pancreatic carcinoma of the pancreatic head is treated by a partial pancreaticoduodenectomy. Its classic variant with resection of the gastric antrum is termed the Kausch-Whipple procedure, or the Whipple-Op. In this procedure, the gallbladder, the distal portion of the bile duct, the duodenum, and naturally the pancreatic head are all removed. Reconstruction is then done with a pancreaticojejunostomy, hepaticojejunostomy, and gastrojejunostomy, usually as Y-Roux reconstruction.. At one time the gastric antrum was resected not for oncological reasons but because anastomosis of the stomach with the small intestine regularly led to severe ulceration in the latter. Then proton pump inhibitors were introduced that could prevent this. Today the gastric antrum is no longer resected, which improves the ...
The study protocol was approved by the institutional review board. From a prospectively collected database of all patients undergoing colorectal surgery in our department, 46 consecutive patients were selected who underwent laparoscopic surgery after preoperative chemoradiation for rectal cancer from January 2009 to June 2014. All patients were diagnosed with adenocarcinoma in the rectum with tumors ,15 cm from the anal verge. Preoperative assessment included digital rectal examination, colonoscopy with biopsy, rectal ultrasound, abdominopelvic computed tomography (CT), chest x-ray, and laboratory data including complete blood cell count, biochemical profiles, serum carcinoembryonic antigen (CEA), and cancer antigen (CA 19-9).. Patients with CTs showing locally advanced tumor (i.e., penetrating through the rectal wall, T3), and/or tumor with lymph node involvement without evidence of distant metastasis were given the option of preoperative chemoradiation therapy. As preoperative chemoradiation ...
OBJECTIVES: We aimed to examine the association between total number of resected nodes and survival in patients after esophagectomy with and without nCRT. BACKGROUND: Most studies concerning the potentially positive effect of extended lymphadenectomy on survival have been performed in patients who underwent surgery alone. As nCRT is known to frequently "sterilize" regional nodes, it is unclear whether extended lymphadenectomy after nCRT is still useful. METHODS: Patients from the randomized CROSS-trial who completed the entire protocol (ie, surgery alone or chemoradiotherapy + surgery) were included. With Cox regression models, we compared the impact of number of resected nodes as well as resected positive nodes on survival in both groups. RESULTS: One hundred sixty-one patients underwent surgery alone, and 159 patients received multimodality treatment. The median (interquartile range) number of resected nodes was 18 (12-27) and 14 (9-21), with 2 (1-6) and 0 (0-1) resected positive nodes, ...
The authors evaluated the combination of etoposide/cyclophosphamide (VP/CY) as initial, presurgical therapy for patients with osteosarcoma and found an 88% response rate for the primary tumor and any metastases. After definitive, limb-salvage surgery and adjuvant chemotherapy with etoposide, cyclophosphamide, cisplatin, and doxorubicin, patients without metastases at diagnosis whose cases were followed for a median of 2 years from diagnosis achieved a relapse-free survival (RFS) probability of 78% +/- 9%. This result is equivalent to the best adjuvant chemotherapy results reported to date. Patients without metastases at diagnosis had significantly better RFS probability (78% +/- 9%) than those with metastases at diagnosis (0%). Transient, severe myelosuppression has been the only major toxicity of the VP/CY courses. No irreversible organ damage or toxic deaths have been seen in patients enrolled in this study. The authors conclude that the combination of VP/CY is effective treatment for ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
The predictive and prognostic value of NLR has been increasingly investigated and implicated for its prognostic and predictive value [7]. In the present retrospective study we show that in early stage breast cancer patients selected for PST, elevated NLR does not predict response to PST nor does it correlate with the prognosis of these patients.. Many groups have investigated the prognostic value of NLR in different tumor types and stages of disease. NLR was demonstrated as independently prognostic in patients with upper gastrointestinal malignancy, more robustly at later stage cancers [7]. In three studies that investigated 470 patients with hepatocellular carcinoma receiving neoadjuvant chemotherapy, an elevated NLR was significantly associated with increased risk of recurrence and risk of death and was an independent predictor of DFS and OS [13-15]. Further studies on 547 patients with oesophageal cancer receiving neoadjuvant chemotherapy reported an association between elevated NLR and poor ...
The antidiabetic drug metformin exhibits potential anticancer properties that are believed to involve both direct (insulin-independent) and indirect (insulin-dependent) actions. Direct effects are linked to activation of AMP-activated protein kinase (AMPK) and an inhibition of mammalian target of rapamycin mTOR signaling, and indirect effects are mediated by reductions in circulating insulin, leading to reduced insulin receptor (IR)-mediated signaling. However, the in vivo impact of metformin on cancer cell signaling and the factors governing sensitivity in patients remain unknown. We conducted a neoadjuvant, single-arm,
Background Whether hepatic arterial infusion (HAI) of oxaliplatin influences the rates of complete pathologic response (CPR) and severe oxaliplatin-related lesions (SOxL) in patients with colorectal...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Inclusion Criteria: - Patients with a histologically confirmed diagnosis of high-grade nonmucinous epithelial ovarian (serous, endometrial, clear cell, carcinosarcoma, an mixed pathologies), fallopian tube, or primary peritoneal cancer that is Stage III or IV according to the International Federation of Gynecology and Obstetrics (FIGO) or tumor, node and metastasis staging criteria. - All patients with Stage IV disease are eligible. This includes those with inoperable disease, those who undergo primary debulking surgery (complete cytoreduction (CC0) or macroscopic disease), or those for whom neoadjuvant chemotherapy is planned. - Patients with Stage III are eligible if they meet one or more of the following criteria: 1. High risk Stage IIIC disease. 2. Planning to receive neoadjuvant chemotherapy. - Patients must provide a blood sample for research at Screening. - Patient must provide sufficient tumor tissue sample (a minimum of 2 formalin-fixed paraffin embedded blocks) at Screening for ...
In the past three decades, several advancements including improvement in surgical techniques and the development of new therapeutic modalities have improved treatment outcomes of rectal cancers. Total mesorectal excision (TME) surgery, which was described by Heald and Ryall [1] in 1982, remarkably improves the clinical outcomes of patients with rectal cancer; thus it has served as the standard surgical procedure for such patients. A 5-year local recurrence rate of 5% in patients who undergone TME surgery alone was reported by MacFarlane et al. [2]. In addition, preoperative concurrent chemoradiotherapy (CCRT) considerably helps in improving the local recurrence rate in patients with locally advanced rectal cancer (LARC). A German study reported a considerable decrease in local recurrence in patients receiving preoperative CCRT [3, 4]. The similar results were also reported by other studies [5-7] and preoperative CCRT has been the recommended treatment for patients with LARC.. Laparoscopic rectal ...
Inhibition of these pathways induces apoptosis in MM cell lines and primary MM cells. It describes the health of a human body as the dynamic homeostasis of four normal Hilits (humours), known as Kan, Phlegm, Safra, and Savda. Recommendations from an international consensus conference on the buy viagra online current status and future of neoadjuvant systemic therapy in primary breast cancer. pylori infection and surgical procedures on the occurrence of gastric ulcer following bariatric surgery. After studying this article, the participant should be able to: 1.. Seven centres in Europe with access to population-based registers of children with Type I diabetes diagnosed under 15 years of age participated in a case-control study of environmental risk factors. Neuroinflammation induces glial aromatase expression in the uninjured songbird brain. To this aim, experiments were carried out at pilot-scale installation with a bioreactor of 250L. The purpose of this study is to verify the possible effects ...
TY - JOUR. T1 - Phase 2 study of erlotinib combined with adjuvant chemoradiation and chemotherapy in patients with resectable pancreatic cancer. AU - Herman, Joseph M.. AU - Fan, Katherine Y.. AU - Wild, Aaron T.. AU - Hacker-Prietz, Amy. AU - Wood, Laura D.. AU - Blackford, Amanda L.. AU - Ellsworth, Susannah. AU - Zheng, Lei. AU - Le, Dung T.. AU - De Jesus-Acosta, Ana. AU - Hidalgo, Manuel. AU - Donehower, Ross C.. AU - Schulick, Richard D.. AU - Edil, Barish H.. AU - Choti, Michael A.. AU - Hruban, Ralph H.. AU - Pawlik, Timothy M.. AU - Cameron, John L.. AU - Laheru, Daniel A.. AU - Wolfgang, Christopher L.. PY - 2013/7/15. Y1 - 2013/7/15. N2 - Purpose: Long-term survival rates for patients with resected pancreatic ductal adenocarcinoma (PDAC) have stagnated at 20% for more than a decade, demonstrating the need to develop novel adjuvant therapies. Gemcitabine- erlotinib therapy has demonstrated a survival benefit for patients with metastatic PDAC. Here we report the first phase 2 study of ...
Results: The mean age was 65 years old and the male/female ratio was 15/2 in Group A. There was no significant difference for operation time (665 vs 685 min, p=0.605) and blood loss (281 vs 169 ml, p=0.57) between Group A and B. The postoperative morbidity in Group A and B was as follows; recurrent nerve palsy (2 vs 0 case), anastomotic leakage (1 vs 0 case) and respiratory diseases (4 vs 5 cases). The mean postoperative hospital stay in Group A was 27 days but the difference was not statistically significant compared to Group B (17 days, p = 0.72 ...
The optimal surgical management of locally advanced breast cancer (LABC) remains undefined. The aim of the study was to obtain long-term results of oncoplastic surgery in terms of overall survival, loco-regional recurrence, and quality of life in case of LABC. Prospective cohort study enrolled 60 patients with stage III breast cancer. Forty-two (70%) patients received neo-adjuvant chemotherapy, 28 patients were considered suitable for surgery as initial treatment option. Type II oncoplastic surgery was performed for all patients: hemimastectomy and breast reconstruction with latissimus dorsi flap - for 29 (48.3%), lumpectomy - 31 (51.7%), and reconstruction with subaxillary flap for four (6.7%), with bilateral reduction mammoplasty - 14 (23.3%) and with J-plastic - 13 (21.7%) patients. Adjuvant chemotherapy and hormonal therapy followed surgery for all, except one, patients. Sequential radiotherapy was administered for all patients. The mean period of follow-up was 86 months. Postoperative morbidity
Purpose: Although intraoperative radiotherapy (IORT) is known to be a method that can reduce local recurrence in locally advanced colorectal cancer, it is not widely used. The aim of this study was to report our experience with IORT for locally advanced rectal cancer. Methods: From 1991 to 1994, nine patients with locally advanced rectal cancer received IORT. External beam radiotherapy was given postoperatively in five patients and preoperatively in three. Seven patients received chemotherapy. IORT was done with 6-MeV or 9-MeV electrons, and 12 Gy was irradiated at the tumor bed. The median follow-up period was 84 months (range, 15 to 208 months). Results: The median age of patients was 51 years (range, 42 to 73 years). All patients had advanced clinical T-stage (cT3/4)cancer. The overall and the disease-free survival rates were 66.7% and 66.7% at 5 years, respectively. One patient developed a local recurrence near the anastomosis site, which was out of the IORT field. Four patients died before ...
The initial literature search identified 7,453 studies. We excluded 1,931 duplicates and excluded 5,504 studies by title screening because they did not meet the eligibility criteria. Eighteen randomized controlled trials were selected for full-text review, and 15 papers were discarded; 6 trials compared surgery alone and surgery plus postoperative radiation, 2 compared surgery alone and preoperative longcourse radiation plus surgery, 6 compared surgery alone and preoperative short-course radiation and surgery, and one was long-term results of a previous reported trial. Three randomized trials comparing preoperative CRT with postoperative CRT in resectable stage II-III rectal cancer were finally identified; Park et al. [9] in 2011, Roh et al. [10] in 2009, and Sauer et al. [5] in 2004 (Fig. 1). All patients in both preoperative and postoperative arms received conventionally fractionated radiotherapy of 50-54 Gy with 1.8-2 Gy per fraction for 5-6 weeks. Concurrent chemotherapy of intravenous ...
The study is being done as a follow-up to a recent clinical trial that showed HER2-positive breast cancer patients using a combination of trastuzumab (Herceptin) and lapatinib (Tykerb) for 12 weeks - without chemotherapy - showed a significant benefit in the eradication of breast cancer tumors.. The study results were released in May 2011 by the American Society of Clinical Oncology.. "Certain subgroups in the study (those that were estrogen receptor positive or negative) showed different complete pathologic response rates (no cancer cells found in the tumor after treatment), so we hypothesized that longer treatment may be more effective for some," said Dr. Mothaffar Rimawi, medical director of the Lester and Sue Smith Breast Center at BCM and study chair. "There may be a group that does not need chemotherapy. It will still be helpful for some, but maybe not for all.". The study will randomize patients to receive 12 vs. 24 weeks of trastuzumab and lapatinib. Patients whose tumors are also ...
Veliparib combined with carboplatin (VC) was an experimental regimen evaluated in the biomarker-rich neoadjuvant I-SPY 2 trial for breast cancer. VC showed improved efficacy in the triple negative signature. However, not all triple negative patients achieved pathologic complete response and some HR+HER2- patients responded. Pre-specified analysis of five DNA repair deficiency biomarkers (BRCA1/2 germline mutation; PARPi-7, BRCA1ness, and CIN70 expression signatures; and PARP1 protein) was performed on 116 HER2- patients (VC: 72 and concurrent controls: 44). We also evaluated the 70-gene ultra-high risk signature (MP1/2), one of the biomarkers used to define subtype in the trial. We used logistic modeling to assess biomarker performance. Successful biomarkers were combined using a simple voting scheme to refine the predicted sensitive group and Bayesian modeling used to estimate the pathologic complete response rates. BRCA1/2 germline mutation status associated with VC response, but its low ...
Sauer Rolf, Fietkau Rainer, Wittekind Christian, Martus Peter, Rödel Claus, Hohenberger Werner, Jatzko Gerhard, Sabitzer Hubert, Karstens Johann-Hinrich, Becker Heinz, Hess Clemens, Raab Rudolf, Adjuvant versus Neoadjuvant Radiochemotherapy for Locally Advanced Rectal Cancer A Progress Report of a Phase-III Randomized Trial (Protocol CAO/ARO/AIO-94) : A Progress Report of a Phase-III Randomized Trial (Protocol CAO/ARO/AIO-94), 10.1007/pl00002396 ...
Radiographic response after neoadjuvant chemotherapy (NAC) for upper tract urothelial carcinoma (UTUC) correlates with pathologic response at the time of nephroureterectomy or distal ureterectomy, Jonathan Coleman, MD, of Memorial Sloan Kettering Cancer Center in New York City, and colleagues reported at the 20th annual meeting of the Society of Urologic Oncology in Washington DC.. In a phase 2 trial of 43 patients with high-risk localized UTUC (ie, high grade disease on biopsy and/or radiographic evidence of cT2-4 disease with positive select cytology), 9 patients had pT0N0, 18 pT1N0, and 16 higher than pT1N0. All underwent computed tomography urography (CTU) before and after NAC unless contraindicated. The initially visible lesion was deemed a mass in 34 (median pre-NAC size: 3.1 cm) and thickening in 9. UTUC disease appeared in the renal pelvis alone in 25 cases, ureter alone in 13, and both areas in 5. Twenty-six patients (60.5%) also displayed hydronephrosis prior to chemotherapy.. After 4 ...
The researchers identified 6 eligible randomized controlled trials. The team found that chemoradiotherapy plus surgery, compared with surgery alone, significantly reduced the 3 year mortality rate (odds ratio 0.53). They also found that preoperative chemoradiotherapy downstaged the tumor. However, the risk for postoperative mortality was higher in the chemoradiotherapy plus surgery group (odds ratio 2.10). Dr Fiorica and colleagues concluded, In patients with resectable esophageal cancer, chemoradiotherapy plus surgery significantly reduces 3 year mortality compared with surgery alone . However, postoperative mortality was significantly increased by neoadjuvant chemoradiotherapy . Further large scale multicenter randomized controlled trials may prove useful to substantiate the benefit on overall survival . ...
The impact of adding bevacizumab to perioperative chemotherapy in patients with colorectal cancer (CRC) undergoing liver resection is yet to be defined. A retrospective review of our patient records showed that the addition of bevacizumab did not increase morbidity or mortality related to liver resection. Pathologic complete response (CR) is associated with prolonged survival. Background: Patients with colorectal cancer (CRC) and liver metastases benefit from perioperative chemotherapy and liver resection. The potential benefit of adding bevacizumab is yet to be defined. The impact of bevacizumab on liver resection complications has been explored in a small number of retrospective studies. Methods: The records of patients with CRC and liver metastases who underwent liver resection and had received perioperative chemotherapy were reviewed. Complications were reported separately for 2 groups (chemotherapy alone vs chemotherapy and bevacizumab). Survival outcomes (progression-free survival [PFS] ...
Preoperative radiation therapy has shown to be of benefit for the prevention of local recurrence rates in rectal cancer patients (11, 12). Long-course preoperative chemoradiotherapy is of benefit in stage T3/T4 rectal cancer patients, and long-course preoperative chemoradiation is the standard of care in the United States (27). However, considering the extensive morbidity of preoperative radiation therapy (13-15), it is of great importance to identify patients with a low risk of local recurrence in which radiation therapy is redundant. With this intention, the current study was done in patients with stage III rectal cancer, as these patients are at the highest risk for local recurrence (12). Our results show that biochemical detection of caspase-3 levels can be used as a marker to identify patients with a very high probability for local cure with surgery alone.. To select patients who can be refrained from preoperative radiation therapy, a marker should provide accurate prediction of clinical ...
We were disappointed to find that adding adjuvant capecitabine to the standard treatment did not significantly improve disease-free or overall survival," continued Martín. "However, given that we found a subset of the patients with nonbasal-like disease seemed to have a significant benefit from capecitabine, and data from the CREATE-X trial showed that adjuvant capecitabine significantly reduced the rate of relapse and improved overall survival when administered to breast cancer patients with residual disease after neoadjuvant chemotherapy, we strongly recommend that patients with triple-negative breast cancer discuss adjuvant capecitabine with their oncologists ...
Of the 449 patients who received neoadjuvant chemotherapy, 98 underwent breast-conserving surgery. The average diameter of the tumors was 5.3 cm, and 87.2% reached a size of up to 3 cm. Moreover, 86.7% were classified as clinical stage III, 74.5% had T3-T4 tumors, 80.5% had N1-N2 axilla, and 89.8% had invasive ductal carcinoma. A pathologic complete response was observed in 27.6% of the tumors, and 100.0% of samples had free margins. The 5-year actuarial overall survival rate was 81.2%, and the mean follow-up was 72.8 months. The rates of ipsilateral breast tumor recurrence and locoregional recurrence were 11.2% and 15.3%, respectively. Multifocal morphology response was the only factor related to ipsilateral breast tumor recurrence disease-free survival ...
Amputation: In the past, complete removal of the affected limb was the main treatment for patients with Ewings sarcoma and resulted in the cure of approximately 20 percent of patients. With the use of neoadjuvant (before surgery) chemotherapy, limb preservation is now possible in over 70 to 80 percent of patients with localized Ewings sarcoma.[1][2] When primary treatment involves limb preservation, amputation is often used to treat recurrences.. Limb Salvage Surgery for Localized Ewings Sarcoma: Wide local excision after neoadjuvant chemotherapy is the most common approach to the treatment of patients with localized Ewings sarcoma. Wide local excision involves surgical removal of the cancer along with some surrounding normal tissue. Surgery for Metastatic or Recurrent Ewings Sarcoma: It is important that the initial surgery remove as much cancer (both the primary cancer and operable areas of metastatic cancer) as possible. Surgery for metastatic lung nodules often involves the removal of ...
The management of rectal cancer has changed in many countries over the last two decades and resulted in improved survival for the majority of rectal cancer patients. In this thesis some surgical strategies and histopathological aspects to improve and clarify the management of rectal cancer patients are investigated.. Even in the era of TME surgery and radiotherapy, a higher local recurrence rate and shorter survival for rectal cancer patients operated with abdominoperineal resection is reported. In the first paper we describe a new strategy with partial anterior en bloc resection of either the prostate or the vagina, resulting in very low local recurrence rates and excellent long-term survival. Histopathological examination of the specimen lays the foundation for decision making on oncological therapy. A positive circumferential resection margin (CRM) has, in previous papers, been related to a high risk of local recurrence. In the second paper we show that a CRM ≤ 1 mm was not correlated with ...
Phase III. Purpose: To evaluate whether radiation to the un-disected axilla and regional lymph noed is inferior to axillary lymph node dissected axilla in terms of invasive breast cancer recurrence-free interval in patient with positive Sentinel Lymph Node after complete of neo-adjuvant chemotherapy. ...
negative disease, progression on endocrine therapy or metastatic disease are typically treated with nonspecific anthracyclineand/or taxane-based chemotherapeutic regimens [5,6]. Neo-adjuvant chemotherapy includes anthracyclines (doxorubicin or epirubicin) followed by surgery and radiation. Adjuvant chemotherapy is more variable, but still anthracycline or taxane based [5,6]. ER positivity is a predictive marker for endocrine therapy. Options for endocrine therapy in breast cancer patients include Selective Estrogen Response Modifiers (SERMs), aromatase inhibitors (AIs), or Selective Estrogen Receptor Down-regulators (SERDs) [5-7]. Selection of endocrine therapy depends on menopausal status and concern about possible side-effects.. In addition to the non-targeted cytotoxic agents described above, breast cancers are also treated with targeted agents. The approved targeted treatments available for breast cancer are in the form of antibodies or small molecule inhibitors that antagonize Her2/neu or ...
BACKGROUND: We previously conducted a prospective phase II clinical trial studying a unique 22-fraction neoadjuvant intensity-modulated radiotherapy with concurrent capecitabine treatment followed by total mesorectal excision for locally advanced rectal cancer. OBJECTIVE: The objective of this study was to retrospectively review the efficacy, toxicity, and surgical complications following intensity-modulated radiotherapy in patients who have rectal cancer. DESIGN: This was a retrospective study. SETTING: Data were gathered from a surgical database. PATIENTS: This study included patients who underwent intensity-modulated radiotherapy with gross tumor volume/clinical target volume of 50.6/41.8 Gy in 22 fractions with concurrent capecitabine treatment over a period of 30 days, after which the patients underwent surgery for rectal cancer in Peking University Cancer Hospital (2007-2013). MAIN OUTCOME MEASURES: The primary end points were acute toxicity, postoperative complications, and complete ...
The study is a phase I/II prospective single cohort clinical feasibility study. 100 patients with early stage resectable malignant pleural mesothelioma will be enrolled into the study. Patients will have a baseline PET scan. Patients on the study will receive IMRT for approximately 1 week of 5 daily treatments. 1 week post-RT, they will proceed with an extrapleural pneumonectomy. If the mediastinal lymph nodes that are removed during surgery are positive for tumour cells, 3 cycles of chemotherapy, consisting of raltitrexed and cisplatin OR Pemetrexed and cisplatin, will be given 6-12 weeks post-surgery. Before and during treatment, side effects will be assessed. After treatment, follow up visits will be conducted every 1 to 2 months for the first year, and every 3 months for the second year. At each visit, a history and physical examination will be performed and ECOG performance status will be assessed. Routine tests will include CBC, liver profile, creatinine and chest x-ray. CT thorax and ...
Although variable prognostic factors (patient age, number and size of metastases, lymph node infiltration, stage of primary disease, prior local recurrence of the primary tumor, and clear resection margin of metastatic lesion) have been suggested in some reports, many authors describe the importance of hormone receptor status as a prognostic factor for the primary tumor after complete resection of BCLM [12,17,20]. Golse and Adam [23] suggested that the best results after the resection of BCLM are achieved after applying selection criteria based on small metastases (, 4-5 cm), minor hepatectomy, radical resection (ideally R0, or R1), stable disease after neoadjuvant therapy, and a delay between primary and secondary lesions longer than 1 or 2 years. Howerver, the age of the patient, her hormone receptor status, and HER2 overexpression are not strong predictors of overall survival [23]. In our study, time to recurrence was relatively short if the metastatic lesion was larger than 5 cm, or there ...
We conducted this phase I trial as a multimodal regimen for patients with oligometastatic colorectal cancer, consisting of 3D-radiotherapy of all metastatic lesions with a concurrently administered standard systemic therapy with capecitabine and oxaliplatin (XELOX regimen) [17, 18]. The primary objective of this study was to determine the maximal tolerable dose (MTD) of local radiotherapy combined with standard chemotherapy. The study used conventionally fractionated radiotherapy under the assumption that this treatment is widely available, safe and effective as known from preoperative radiotherapy in locally advanced rectal cancer.. Most commonly, local disease control can be assessed by pathohistological response, which is likely correlated with relapse free suvival after 5-FU based chemoradiotherapy. Pathological complete response (pCR) rates following fluoropyrimidine based chemoradiation have been reported in 15-20% of patients. Many phase II trials indicate, that the rate of ...
September 8, 2011 , The study conducted by the Radiation Therapy Oncology Group (RTOG 9410) is the largest randomized trial to confirm the importance of administering chemotherapy and radiotherapy concurrently rather than sequentially for patients with locally-advanced non-small cell lung cancer (NSCLC).. Philadelphia, PA-Nearly 50,000 Americans are diagnosed each year with stage III or locally advanced NSCLC, for which surgery is usually not a viable treatment option. Optimizing nonsurgical treatment strategies for these patients is an ongoing research endeavor. In the August xx, 2011 issue of the Journal of the National Cancer Institute, RTOG researchers report that treating patients with concurrent chemotherapy and radiation therapy significantly increased five-year survival rates compared with treating patients with radiation therapy upon completion of chemotherapy treatment.. "The significant increase in five-year survival for patients receiving concurrent versus sequential treatment ...
The purpose of this study was to evaluate the efficacy and safety of volumetric modulated arc therapy (VMAT) after extrapleural pneumonectomy (EPP) in patients with malignant pleural mesothelioma (MPM). A total of 15 patients who received VMAT after EPP were enrolled. All patients were males, and the median age was 67 years (Stage IB in two, II in six, and III in seven patients). The clinical target volume (CTV) included the entire preoperative ipsilateral hemithorax and involved nodal stations. The CTV was generally expanded by 10-15 mm beyond the planning target volume (PTV). The dose prescription was designed to cover 95% of the PTV with 54 Gy in 30 fractions. The median follow-up period was 11 months. Treatment-related toxicities were evaluated by Common Terminology Criteria for Adverse Events (CTCAE) ver. 4. One-year local control, disease-free survival, and overall survival rates were 55.7% [95% confidence interval (CI): 25.6-85.8%], 29.3% (95% CI: 5.3-53.3%), and 43.1% (95% CI: ...
Local recurrence is a major cause of morbidity and mortality, usually implies a worse prognosis. It may occur as a result from two potential etiopathogeneses. First, metastases through endothelial-lined channels occur to both lymphatic and hematogenous routes [18], which are controlled by neoadjuvant therapy and optimal TME. Indeed, TME reduced the high local recurrence rates from 30-40% to 5-10% [19] and even greater when associated with chemoradiotherapy (CRT) [20]. The second is by implantation of viable exfoliated malignant cells from a rectal adenocarcinoma on preexisting benign perineal lesions [21-24]; it was estimated that 70% of the specimens were found to have viable exfoliated colorectal cancer cells with median cell number ranging from 0.55 × 105 to 0.78 × 10 [6].. Since the first case of cell implantation into the anal fistula in 1954 by Guiss [4], several case reports and small case series reported the colorectal cancer recurrence on preexisting benign perineal lesions such as ...
Historically, the approach of pre-operative radiation therapy with a combination of external beam radiation and low dose-rate (LDR) brachytherapy to doses of 60-70 Gy prescribed to point A was a standard approach in patients with endometrial cancer and significant co-morbidities. 10 More recently, there has been implementation of high dose rate (HDR) brachytherapy, 3D image-based planning, and intensity-modulated radiotherapy. In a study by Vargo et al, 11 the investigators evaluated patients with endometrial cancer who also had clinical involvement of the cervix with neoadjuvant external beam radiotherapy (45-50.4 Gy in 25-28 fractions) and image-based HDR brachytherapy (5-5.5 Gy times 3-4 fractions) plus chemotherapy followed by extra-fascial hysterectomy performed at a median of 6 weeks after radiotherapy. The authors found that at the time of surgery 91% of patients had no clinical cervical involvement, 58% had no pathological cervical involvement, and 24% had a complete pathologic response. ...
Visual estimation of tumor and stroma proportions in microscopy images yields a strong, Tumor-(lymph)Node- Metastasis (TNM) classification-independent predictor for patient survival in colorectal cancer. Therefore, it is also a potent (contra)indicator for adjuvant chemotherapy. However, quantification of tumor and stroma through visual estimation is highly subject to intra- and inter-observer variability. The aim of this study is to develop and clinically validate a method for objective quantification of tumor and stroma in standard hematoxylin and eosin (H and E) stained microscopy slides of rectal carcinomas. A tissue segmentation algorithm, based on supervised machine learning and pixel classification, was developed, trained and validated using histological slides that were prepared from surgically excised rectal carcinomas in patients who had not received neoadjuvant chemotherapy and/or radiotherapy. Whole-slide scanning was performed at 20× magnification. A total of 40 images (4 million ...
Visual estimation of tumor and stroma proportions in microscopy images yields a strong, Tumor-(lymph)Node- Metastasis (TNM) classification-independent predictor for patient survival in colorectal cancer. Therefore, it is also a potent (contra)indicator for adjuvant chemotherapy. However, quantification of tumor and stroma through visual estimation is highly subject to intra- and inter-observer variability. The aim of this study is to develop and clinically validate a method for objective quantification of tumor and stroma in standard hematoxylin and eosin (H and E) stained microscopy slides of rectal carcinomas. A tissue segmentation algorithm, based on supervised machine learning and pixel classification, was developed, trained and validated using histological slides that were prepared from surgically excised rectal carcinomas in patients who had not received neoadjuvant chemotherapy and/or radiotherapy. Whole-slide scanning was performed at 20× magnification. A total of 40 images (4 million ...
A new joint clinical practice guideline from the American Society of Clinical Oncology (ASCO) and the Society of Gynecologic Oncology (SGO) states that neoadjuvant chemotherapy (NACT) is the optimal first-line treatment for some women who have newly diagnosed advanced ovarian cancer. While the standard of care in this setting is primary cytoreductive surgery (PCS) followed […]. ...
https://investors.merck.com/news/press-release-details/2019/Mercks-KEYTRUDA-pembrolizumab-Plus-Chemotherapy-Showed-Statistically-Significant-Increase-in-Pathological-Complete-Response-Versus-Chemotherapy-as-Neoadjuvant-Therapy-in-Early-Stage-Triple-Negative-Breast-Cancer-TNBC/default.aspx. Trial of intraoperative cell salvage versus transfusion in ovarian cancer (TIC TOC): protocol for a randomised controlled feasibility study.. Body mass index and sexual function in women with gynaecological cancer. AspECT A Phase III randomised study of aspirin and esomeprazole chemoprevention in Bareetts metaplasia. Randomized Phase II Study Evaluating Palbociclib in Addition to Letrozole as Neoadjuvant Therapy in Estrogen Receptor-Positive Early Breast Cancer: PALLET Trial.. Esomeprazole and aspirin in Barretts oesophagus (AspECT): a randomised factorial trial. Intermittent chemotherapy plus either intermittent or continuous cetuximab for first-line treatment of patients with KRAS wild-type advanced ...
Background: The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients average 5 year survival rate from 20% to 70% in the past 30 years. However, for patients who progress after chemotherapy, its effectiveness diminishes due to the emergence of multi-drug resistance (MDR) after prolonged therapy. Methodology/Principal Findings: In order to overcome both the dose-limiting side effects of conventional chemotherapeutic agents and the therapeutic failure resulting from MDR, we designed and evaluated a novel drug delivery system for MDR1 siRNA delivery. Novel biocompatible, lipid-modified dextran-based polymeric nanoparticles were used as the platform for MDR1 siRNA delivery; and the efficacy of combination therapy with this system was evaluated. In this study, multi-drug resistant osteosarcoma cell lines (KHOSR2 and U-2OSR2) were treated with the MDR1 siRNA nanocarriers and MDR1 protein (P-gp) expression, drug retention, and immunofluoresence were analyzed. Combination therapy of
As the second installment in a series of webcasts aimed at educating physicians and the general public about new, innovative surgical procedures, surgeons at Brigham and Womens Hospital (BWH) will demonstrate a type of cancer surgery that generally extends the lives of patients stricken by mesothelioma, an aggressive form of cancer most often associated with exposure to asbestos. The webcast will take place on May 1 at 4:30 P.M. EST and can be accessed by going to www.brighamandwomens.org/surgerywebcast.. The procedure is known as extrapleural pneumonectomy, and is performed on patients suffering from malignant pleural mesothelioma, a form of cancer that occurs in the cells that line the chest cavity. The operation consists of the surgeon removing the thin membrane of tissue that covers the lungs and the heart, as well as a lung and the diaphragmatic muscle. Although not experimental, the surgery is not widely done due to its complexity, and the relative rarity of the type of cancer the ...
One alternative to mammography, Breast MRI or contrast enhanced magnetic resonance imaging (MRI), has shown substantial progress in the detection of breast cancer. Screening for malignancy in women with greater than 20% lifetime risk of breast cancer. Evaluate breast implants for rupture. Screening the contralateral breast for malignancy in women with known unilateral breast malignancy. Extent of disease and the presence of multifocality and multicentricity in patients with invasive carcinoma and ductal carcinoma in situ (DCIS). Evaluate response to neoadjuvant chemotherapy. The available literature suggests that the sensitivity of contrast-enhanced breast MRI in detection of cancer is considerably higher than that of either radiographic mammography or ultrasound and is generally reported to be in excess of 94%. The specificity (the confidence that a lesion is cancerous and not a false positive) is only fair (modest), (or 37%-97%) thus a positive finding by MRI should not be interpreted as a ...

Repair of Type V TAAA Using Selective Celiac, Superior Mesenteric, and Renal Artery Perfusion  | CTSNetRepair of Type V TAAA Using Selective Celiac, Superior Mesenteric, and Renal Artery Perfusion | CTSNet

... implantation of the both renal arteries, celiac and superior mesenteric arteries with the use of a self made quadrifurcated ... The celiac, superior mesenteric, and right and left renal arteries were divided and cannulated. Selective perfusion with whole ... Repair of Type V TAAA Using Selective Celiac, Superior Mesenteric, and Renal Artery Perfusion Tuesday, November 29, 2016 ... A 22 mm graft with three previously constructed branches corresponding to the celiac, SMA, and right renal arteries was ...
more infohttps://www.ctsnet.org/article/repair-type-v-taaa-using-selective-celiac-superior-mesenteric-and-renal-artery-perfusion

2201F08circulation2post - iliac common iliac Celiac artery Superior mesenteric artery Inferior mesenteric artery Gonadal...2201F08circulation2post - iliac common iliac Celiac artery Superior mesenteric artery Inferior mesenteric artery Gonadal...

... iliac common iliac Celiac artery Superior mesenteric artery Inferior mesenteric artery Gonadal (testicular, ovarian) renal ... arteries 0! the head and trunk Internal camtld artery External carotid artery Common ... Unformatted text preview: iliac common iliac Celiac artery Superior mesenteric artery Inferior mesenteric artery Gonadal ( ... 2201F08circulation2post - iliac common iliac Celiac artery.... This preview shows document pages 1 - 16. Sign up to view the ...
more infohttps://www.coursehero.com/file/244853/2201F08circulation2post/

Superior Mesenteric Artery Anatomy Awesome Celiac Artery - Neural AnatomySuperior Mesenteric Artery Anatomy Awesome Celiac Artery - Neural Anatomy

... level 1 instruction arteries & veins atlas of anatomy image result for superior mesenteric artery science natural phenomena & ... medicine inferior mesenteric superior mesenteric artery superior mesenteric artery ischemic colitis. That image (Superior ... Superior Mesenteric Artery Anatomy Awesome Celiac Artery October 7, 2018. Zachary Williams ... To see most photographs throughout New Pics Of Superior Mesenteric Artery Anatomy graphics gallery remember to abide by this ...
more infohttp://greycouncil.us/superior-mesenteric-artery-anatomy/superior-mesenteric-artery-anatomy-awesome-celiac-artery/

One visceral artery may be enough; successful pancreatectomy in a patient with total occlusion of the celiac and superior...One visceral artery may be enough; successful pancreatectomy in a patient with total occlusion of the celiac and superior...

A collateral circulation from a hypertrophic inferior mesenteric artery to the celiac trunk and the superior mesenteric artery ... artery arising from the celiac trunk and one pancreatico-duodenal arcade between the celiac trunk and the superior mesenteric ... adenocarcinoma of the pancreas with complete atherosclerotic occlusion of the celiac trunk and the superior mesenteric artery. ... Two years later, she required endovascular repair of an aortic rupture during which the inferior mesenteric artery was ...
more infohttps://bmcsurg.biomedcentral.com/articles/10.1186/s12893-018-0352-0

Small Bowel - Shelf-Life Flashcards by Ali Khalid | BrainscapeSmall Bowel - Shelf-Life Flashcards by Ali Khalid | Brainscape

A. Celiac artery and superior mesenteric arteries. B. Inferior mesenteric artery and superior mesenteric arteries ... B. Inferior mesenteric artery and superior mesenteric arteries *The blood supply to the majority of the small bowel is through ... Although the superior mesenteric artery does supply the majority of the small bowel, the pancreaticoduodenal arteries (superior ... Although branches of the superior mesenteric artery do supply the distal small bowel, the celiac artery does not. ...
more infohttps://www.brainscape.com/flashcards/small-bowel-shelf-life-2733811/packs/4633631

EX2 Lower Abdomen Flashcards by Courtney Kast | BrainscapeEX2 Lower Abdomen Flashcards by Courtney Kast | Brainscape

celiac trunk. superior mesenteric artery. inferior mesenteric artery 25 This artery supplies the liver, gall bladder, esophagus ... Which organ is a major site of anastomoses between the superior and inferior mesenteric arteries ... This artery sends 15-18 intestinal arteries to the small intestine and supplies the proximal 2/3 of transverse colon ... What branches of superior mesenteric supply the proximal 2/3 of the transverse colon ...
more infohttps://www.brainscape.com/flashcards/ex2-lower-abdomen-1912672/packs/3986988

Department of Radiology - Research Output
     - Penn StateDepartment of Radiology - Research Output - Penn State

Blunt traumatic injury to the superior mesenteric artery and celiac axis. Brown, D. B., Singh, H., Atnip, R., Cardella, J. F ... Use of a Palmaz stent deployed in the superior mesenteric artery for chronic mesenteric ischemia. Waybill, P. N. & Enea, N. A ... Technical factors of CT angiography studied with a carotid artery phantom. Wise, S. W., Hopper, K. D., Schwartz, T. A., Ten ...
more infohttps://pennstate.pure.elsevier.com/en/organisations/department-of-radiology-2/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&ordering=publicationYearThenTitle&descending=false&page=4

Perioperative Therapy for Resectable Pancreatic Cancer - Full Text View - ClinicalTrials.govPerioperative Therapy for Resectable Pancreatic Cancer - Full Text View - ClinicalTrials.gov

Clear fat plane around celiac and superior mesenteric arteries (SMA). *Patent superior mesenteric vein (SMV) and portal vein ( ... Gastroduodenal artery (GDA) encasement up to origin at hepatic artery. * Tail of pancreas:. *Adrenal, colon or mesocolon, or ... Distant metastases (includes celiac and/or para-aortic); at the discretion of the treating surgeon, body and tail lesions that ... have positive celiac and/or para-aortic nodes in close vicinity to the primary may be borderline rather than unresectable ...
more infohttps://clinicaltrials.gov/show/NCT00609336

A new mild hyperthermia device to treat vascular involvement in cancer surgery | Scientific ReportsA new mild hyperthermia device to treat vascular involvement in cancer surgery | Scientific Reports

... an in vivo cancer model for these studies as it is a representative model of a tumor that commonly involves major mesenteric ... Multivisceral Ex Vivo Surgery for Tumors Involving Celiac and Superior Mesenteric Arteries. American Journal of Transplantation ... in particular the superior mesenteric artery (SMA)14, 15 (Figure S1A-C). Our method for applying hyperthermia was through a ... Untreated femoral artery (B) femoral artery exposed to 46 °C for 10 mins and (C) femoral artery exposed to 55 °C for 10 mins. ( ...
more infohttps://www.nature.com/articles/s41598-017-10508-6?error=cookies_not_supported&code=ebaa6f99-e98b-464b-9147-10b4dd45fd90

Prevalência da estenose aterosclerótica do tronco celíaco e da artéria mesentérica superior na arteriopatia oclusiva dos...Prevalência da estenose aterosclerótica do tronco celíaco e da artéria mesentérica superior na arteriopatia oclusiva dos...

... arteries circulation in a less invasive manner and assess the flow in celiac trunk (CT) and superior mesenteric artery (SMA), ... mesenteric artery and /or the celiac trunk. The atherosclerosis in the superior mesenteric artery is associated with ischemic ... Asymptomatic celiac and superior mesenteric artery stenosis are more prevalent among patients with unsuspected renal artery ... Prevalence of atherosclerotic stenosis of celiac trunk and superior mesenteric artery in occlusive arteriopathy of lower limbs ...
more infohttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-54492010000100002&lng=pt&nrm=iso&tlng=en

Gemcitabine, Bevacizumab, and Abdominal Radiation Therapy in Treating Patients With Localized Pancreatic CancerGemcitabine, Bevacizumab, and Abdominal Radiation Therapy in Treating Patients With Localized Pancreatic Cancer

Clear fat plane around celiac and superior mesenteric arteries. - Patent superior mesenteric vein/portal vein. - Tumors ... Severe unilateral superior mesenteric vein/portal impingement. - Tumor abutment on the superior mesenteric artery. - ... Gastroduodenal artery encasement up to the origin at the hepatic artery. - Colon invasion NOTE: *Determination of resectability ...
more infohttp://www.knowcancer.com/cancer-trials/NCT00460174/

MedicineMedicine

Successful conservative treatment of acute traumatic occlusions of the celiac artery and superior mesenteric artery: A case ... Unique imaging findings in fibromuscular dysplasia of renal arteries: A case report. Kong, Weiying; Hu, Zhangxue ... Radial artery occlusion with a kaolin-filled pad after transradial cardiac catheterization. Chiang, Chun-Yen; Chang, Weng-Ting ...
more infohttps://journals.lww.com/md-journal/pages/default.aspx

Circulatory, Vascular and Cardiac sub-cluster 3Circulatory, Vascular and Cardiac sub-cluster 3

Mycotic aneurysm of the celiac trunk and superior mesenteric artery in a ... ... Neopulmonary artery stenosis may occur after the arterial switching procedure to correct transposition of the great arteries. ... Mycotic aneurysms of the celiac artery are extremely rare, and in our review of the literature we found that in only one case ... Each patient had hemoptysis and in each case there was hemothorax caused by a ruptured mycotic aneurysm of the celiac artery. ...
more infohttp://www.biomedsearch.com/cluster/26/Circulatory-Vascular-and-Cardiac/sub-3-p10.html

Japanese Journal of Vascular SurgeryJapanese Journal of Vascular Surgery

Postoperative angiography revealed thrombotic occlusion of the celiac and superior mesenteric arteries. ... ischemic necrotic colitis due to arterial thrombosis because pulsation of the superior mesenteric artery and celiac artery was ... because of the bowel necrosis caused by concomitant dissection in the superior mesenteric artery. The case has been forced to ... We performed right hemicolectomy and splenectomy, plus retrograde mesenteric and celiac bypass by a saphenous vein graft. The ...
more infohttps://www.jstage.jst.go.jp/browse/jsvs/15/1/_contents/-char/en

Emergency UltrasoundEmergency Ultrasound

Image the superior mesenteric artery (SMA) and celiac artery. Image renal arteries if origins are seen. ... Enlarged view of the right common iliac artery shows the large amount of intraluminal thrombus (T) commonly found in aneurysms ... Get a longitudinal image of each iliac artery. ... of the aorta and iliac arteries. The patent lumen is indicated ... longitudinal and transverse images of entire abdominal aorta and a transverse view of bifurcation to show the iliac arteries. ...
more infohttps://www.med-ed.virginia.edu/courses/rad/edus/epig1.html

Lumbar false aneurysms following image-guided interventive procedures for spondylodiskitic abscesses.Lumbar false aneurysms following image-guided interventive procedures for spondylodiskitic abscesses.

Pseudoaneurysms of the lumbar arteries are infrequent, and are most often found incidentally after trauma to the lumbar spine. ... 18670849 - Successful treatment of pseudoaneurysms of celiac and superior mesenteric arteries by c.... 19995799 - ... We report two cases of lumbar artery false aneurysms arising as a complication during the treatment of infectious disciitis. ... Pseudoaneurysms of the lumbar arteries are infrequent, and are most often found incidentally after trauma to the lumbar spine. ...
more infohttp://www.biomedsearch.com/nih/Lumbar-false-aneurysms-following-image/16528549.html

Spontaneous dissection of the celiac artery: a case report. - Semantic ScholarSpontaneous dissection of the celiac artery: a case report. - Semantic Scholar

We describe a spontaneous dissection of the celiac artery that was identified by computed tomographic scan in an otherwise ... Spontaneous dissection of visceral arteries is rare in the absence of concurrent dissection of the aorta, iatrogenic injury ... Spontaneous Isolated Celiac Artery and Superior Mesenteric Artery Dissections: A Rare Case. Sonay Aydin, Elif Ergun, Erdem ... Spontaneous dissection of visceral arteries is rare in the absence of concurrent dissection of the aorta, iatrogenic injury ...
more infohttps://www.semanticscholar.org/paper/Spontaneous-dissection-of-the-celiac-artery%3A-a-case-Woolard-Ammar/91895e91c51e818a0aa422565ad5eba4acf87121

Splanchnic Vasoregulation After Major Abdominal Surgery in Pigs | SpringerLinkSplanchnic Vasoregulation After Major Abdominal Surgery in Pigs | SpringerLink

Superior Mesenteric Artery Celiac Trunk Pulmonary Artery Occlusion Pressure Blood Flow Redistribution pCO2 Gradient These ... arteries. Blood flow was significantly decreased in the mesenteric artery (25% decrease, p = 0.007) and portal vein (13% ... Toung T, Reilly PM, Fuh KC et al (2000) Mesenteric vasoconstriction in response to hemorrhagic shock. Shock 13:267-273PubMed ... Postoperative blood flow was significantly increased in the celiac trunk (76% increase [percentage of baseline flow], p = 0.003 ...
more infohttps://link.springer.com/article/10.1007%2Fs00268-010-0560-y

Abdominal aortic aneurysm rupture | Radiology Case | Radiopaedia.orgAbdominal aortic aneurysm rupture | Radiology Case | Radiopaedia.org

... the origin of the inferior mesenteric artery is occluded by soft thrombus. Preserved origin of the celiac, superior mesenteric ... Its neck is 4 cm inferior to the renal arteries origin. It extends to involve the right common iliac artery. It measures 10 cm ... The proximal 5 cm of the left internal iliac artery is fusiform dilated measuring 2.4 cm. Left common iliac artery proximal ... between the aneurysm neck and renal arteries axial dimension 3.1 x 3.2 cm. Above the renal artery measures 2.7 x 2.8 cm in ...
more infohttps://radiopaedia.org/cases/abdominal-aortic-aneurysm-rupture-1?lang=us

Bassett Collection Large Image - Lane Medical Library, Stanford University Medical CenterBassett Collection Large Image - Lane Medical Library, Stanford University Medical Center

Upper pointer: Celiac trunk Lower pointer: Superior mesenteric artery 20 . Upper pointer: Aortic hiatus Lower pointer: Left ... Phrenic arteries 8 . Right pointer: Duodenal suspensory muscle (cut off near attachment to right crus of diaphragm) Left ... pointer: Greater splanchnic nerve (celiac ganglion removed) 9 . Right pointer: Right crus lumbar part diaphragm Left pointer: ...
more infohttp://lane.stanford.edu/biomed-resources/bassett/raw/bassettLargerView.html?t=largerView&bn=130-6

Cancers  | Free Full-Text | Survival Analysis in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Chemoradiotherapy...Cancers | Free Full-Text | Survival Analysis in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Chemoradiotherapy...

... superior mesenteric vein (SMV)/portal vein (PV) involvement alone; n = 27), BR-A (borderline resectable, arterial involvement; ... a) PV (Portal vein); (b) SMA (Superior mesenteric artery); (c) CA (Celiac artery); (d) CHA (Common hepatic artery). MST: median ... Among the patients in whom down-staging was not achieved, those with no encasement and deformity of major arteries such as CA, ... a) PV (Portal vein); (b) SMA (Superior mesenteric artery); (c) CA (Celiac artery); (d) CHA (Common hepatic artery). MST: median ...
more infohttps://www.mdpi.com/2072-6694/10/3/65/htm

An eight-branched aortic graft for reconstruction of visceral and intercostal arteries during extent II thoraco-abdominal...An eight-branched aortic graft for reconstruction of visceral and intercostal arteries during extent II thoraco-abdominal...

"An eight-branched aortic graft for reconstruction of visceral and intercostal arteries during extent II thoraco-abdominal ... Thoraco-abdominal and abdominal aortic aneurysms involving renal, superior mesenteric, celiac arteries . Ann Surg 1974 ; 179 : ... SMA: superior mesenteric artery; TAAA: thoraco-abdominal aortic aneurysm. Figure 1 View largeDownload slide (A) The octopod ... Thoraco-abdominal and abdominal aortic aneurysms involving renal, superior mesenteric, celiac arteries . Ann Surg 1974 ; 179 : ...
more infohttps://www.deepdyve.com/lp/ou_press/an-eight-branched-aortic-graft-for-reconstruction-of-visceral-and-fT5o5EFgFj

Gallbladder - SuperpageGallbladder - Superpage

N2: Metastases to periaortic, pericaval, superior mesenteric artery or celiac artery lymph nodes. Distant metastasis (M) - ... Vasculature: supplied by cystic artery, usually a branch of right hepatic artery. ● Note: variations of bile ducts and arteries ... hepatic artery, portal vein, cystic duct); also celiac, periduodenal, peripancreatic and superior mesenteric nodes. Drawings. ... Fibrinoid necrosis of small artery associated with lymphocytes and macrophages. Benign gallbladder tumors. Adenoma of ...
more infohttp://www.pathologyoutlines.com/topic/gallbladdersuperpage.html

A Comparison of Renal Perfusion in Thoracoabdominal Aortic Aneurysm (TAAA) Repair - Full Text View - ClinicalTrials.govA Comparison of Renal Perfusion in Thoracoabdominal Aortic Aneurysm (TAAA) Repair - Full Text View - ClinicalTrials.gov

The flow rates into the renal arteries range from 100 to 450 ml/min. The celiac axis and superior mesenteric artery remain ... After the aorta is clamped and opened, the renal arteries are perfused with lactated Ringers solution (LR) that has been cooled ... This randomized trial compared the effectiveness of two forms of renal artery perfusion, cold LR versus cold blood, to identify ... Currently, normothermic blood and cold LR remain the two most commonly used methods of renal artery perfusion during TAAA ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT00691756

Prevalência da estenose aterosclerótica do tronco celíaco e da artéria mesentérica superior na arteriopatia oclusiva dos...Prevalência da estenose aterosclerótica do tronco celíaco e da artéria mesentérica superior na arteriopatia oclusiva dos...

REIS, Wenes Pereira et al. Prevalence of atherosclerotic stenosis of celiac trunk and superior mesenteric artery in occlusive ... The occasional relationship between arterial atherosclerosis of lower limbs and atherosclerosis of intestinal arteries has not ... Objective: To assess the presence of lesions with ≥ 70% stenosis in the superior mesenteric artery and/or in the celiac trunk ... Keywords : Stenosis; vascular ultrasound; superior mesenteric artery; celiac trunk. · abstract in Portuguese · text in English ...
more infohttp://www.scielo.br/scielo.php?script=sci_abstract&pid=S1677-54492010000100002&lng=en&nrm=iso&tlng=en
  • We use pancreatic ductal adenocarcinoma as an in vitro and an in vivo cancer model for these studies as it is a representative model of a tumor that commonly involves major mesenteric vessels. (nature.com)
  • By selectively infiltrating and destroying the internal elastica of a major cerebral artery, Aspergillus fungus (Af) induces disruption and incipient dilatation of the vascular wall with or without inflammation. (biomedsearch.com)
  • Occlusion of one artery are mostly asymptomatic but may become clinically relevant when surgery of the liver, bile duct or the pancreas is required. (biomedcentral.com)
  • We report the case of a 26-month-old male who developed a mycotic aneurysm 9 months following insertion of a ventricle to pulmonary artery conduit. (biomedsearch.com)
  • For a long time, the study of digestive arteries was performed through autopsies 9,10 and arteriographies. (scielo.br)
  • 8 However, the relation between intestinal arteries atherosclerosis with lower limbs atherosclerosis have received little attention. (scielo.br)