Cefuroxime: Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.Cephalosporins: A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.Cefaclor: Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Cefamandole: Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate.Amoxicillin-Potassium Clavulanate Combination: A fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate.Clavulanic Acids: Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.Penicillin Resistance: Nonsusceptibility of an organism to the action of penicillins.Ceftizoxime: A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.Cephradine: A semi-synthetic cephalosporin antibiotic.CephalosporinaseFurans: Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.Antibiotic Prophylaxis: Use of antibiotics before, during, or after a diagnostic, therapeutic, or surgical procedure to prevent infectious complications.Cephalothin: A cephalosporin antibiotic.Suspensions: Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.Cephalexin: A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.Prodrugs: A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.Phenylmercury Compounds: Organic mercury compounds in which the mercury is attached to a phenyl group. Often used as fungicides and seed treatment agents.Cefotaxime: Semisynthetic broad-spectrum cephalosporin.Gonorrhea: Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.Haemophilus influenzae: A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII.Cephaloridine: A cephalosporin antibiotic.Anti-Infective Agents: Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.Cefazolin: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.Drug Resistance, Microbial: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Dicloxacillin: One of the PENICILLINS which is resistant to PENICILLINASE.Cefoxitin: A semisynthetic cephamycin antibiotic resistant to beta-lactamase.Penicillin V: A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.Bronchitis: Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.Insurance, Pharmaceutical Services: Insurance providing for payment of services rendered by the pharmacist. Services include the preparation and distribution of medical products.Medicare Part D: A stand-alone drug plan offered by insurers and other private companies to beneficiaries that receive their Medicare Part A and/or B benefits through the Original Medicare Plan. It includes Medicare Private Fee-for-Service Plans that do not offer prescription drug coverage and Medicare Cost Plans offering Medicare prescription drug coverage. The plan was enacted as the Medicare Prescription Drug, Improvement and Modernization Act of 2003 with coverage beginning January 1, 2006.Insurance Benefits: Payments or services provided under stated circumstances under the terms of an insurance policy. In prepayment programs, benefits are the services the programs will provide at defined locations and to the extent needed.Medicare: Federal program, created by Public Law 89-97, Title XVIII-Health Insurance for the Aged, a 1965 amendment to the Social Security Act, that provides health insurance benefits to persons over the age of 65 and others eligible for Social Security benefits. It consists of two separate but coordinated programs: hospital insurance (MEDICARE PART A) and supplementary medical insurance (MEDICARE PART B). (Hospital Administration Terminology, AHA, 2d ed and A Discursive Dictionary of Health Care, US House of Representatives, 1976)Medicare Part C: The Balanced Budget Act (BBA) of 1997 establishes a Medicare+Choice program under part C of Title XVIII, Section 4001, of the Social Security Act. Under this program, an eligible individual may elect to receive Medicare benefits through enrollment in a Medicare+Choice plan. Beneficiaries may choose to use private pay options, establish medical savings accounts, use managed care plans, or join provider-sponsored plans.United StatesTablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Protective Devices: Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.Universal Precautions: Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.Tablets, Enteric-Coated: Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Rats, Inbred F344F Factor: A plasmid whose presence in the cell, either extrachromosomal or integrated into the BACTERIAL CHROMOSOME, determines the "sex" of the bacterium, host chromosome mobilization, transfer via conjugation (CONJUGATION, GENETIC) of genetic material, and the formation of SEX PILI.F2-Isoprostanes: Isoprostanes derived from the free radical oxidation of ARACHIDONIC ACID. Although similar in structure to enzymatically synthesized prostaglandin F2alpha (DINOPROST), they occur through non-enzymatic oxidation of cell membrane lipids.Prochlorococcus: A genus of marine planktonic CYANOBACTERIA in the order PROCHLOROPHYTES. They lack PHYCOBILISOMES and contain divinyl CHLOROPHYLL, a and b.Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Monoiodotyrosine: A product from the iodination of tyrosine. In the biosynthesis of thyroid hormones (THYROXINE and TRIIODOTHYRONINE), tyrosine is first iodized to monoiodotyrosine.Diiodotyrosine: A product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones (THYROXINE and TRIIODOTHYRONINE).

Levofloxacin versus cefuroxime axetil in the treatment of acute exacerbation of chronic bronchitis: results of a randomized, double-blind study. (1/269)

A randomized, double-blind, double-dummy, three-arm parallel design, multicentre study was conducted among adult patients with acute exacerbation of chronic bronchitis (AECB) in order to compare the efficacy and safety of two different doses of levofloxacin with cefuroxime axetil. A total of 832 patients were randomized to receive oral levofloxacin (250 mg od or 500 mg od) or oral cefuroxime axetil (250 mg bd) for 7-10 days. The primary efficacy analysis was based on the clinical response in patients with bacteriologically confirmed AECB, determined 5-14 days after the end of therapy (per-protocol population). Of 839 patients enrolled (at 71 centres in 14 countries), seven were not treated, giving an intention-to-treat (ITT) population of 832. In total, 281 patients received levofloxacin 250 mg, 280 received levofloxacin 500 mg and 271 received cefuroxime axetil. The cure rates in the ITT population were: levofloxacin 250 mg, 70% (196/281); levofloxacin 500 mg, 70% (195/280); cefuroxime axetil, 61% (166/271); those in the per-protocol population were: 78% (121/156), 79% (108/137) and 66% (88/134), respectively. Both doses of levofloxacin were at least as effective as cefuroxime axetil and were active against the main pathogens of clinical relevance (Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis). All three treatment regimens were equally well tolerated. In conclusion, the results show that levofloxacin (250 mg and 500 mg) od is effective and well tolerated in the treatment of AECB in adult patients.  (+info)

Anti-pneumococcal activity of gatifloxacin compared with other quinolone and non-quinolone agents. (2/269)

An agar dilution MIC method was used to test the activity of gatifloxacin, a new broad-spectrum fluoroquinolone, compared with ciprofloxacin, levofloxacin, sparfloxacin, trovafloxacin, amoxycillin, cefuroxime, ceftriaxone and clarithromycin against 71 penicillin-susceptible, 81 penicillin-intermediate and 55 penicillin-resistant pneumococci. Quinolone activity was unaffected by penicillin susceptibility, with MIC50/MIC90s (mg/L) of 0.25/0.5 for gatifloxacin; 1/2 for ciprofloxacin; 1/2 for levofloxacin; 0.25/0.5 for sparfloxacin; 0.125/0.25 for trovafloxacin. beta-Lactam and clarithromycin MICs rose with those of penicillin G; MIC50/MIC90 values (mg/L) for penicillin-susceptible, -intermediate and -resistant strains were: 0.03/0.06, 0.25/1, 2/4 for penicillin G; 0.03/0.03, 0.125/1, 2/4 for amoxycillin; 0.03/0.125, 0.5/4, 8/16 for cefuroxime; 0.03/0.03, 0.25/0.5, 2/4 for ceftriaxone; 0.03/0.06, 0.03/>64, 1/>64 for clarithromycin. Time-kill testing of four penicillin-susceptible, four -intermediate and four -resistant strains showed that levofloxacin at the MIC, gatifloxacin and sparfloxacin at 2 x MIC, and trovafloxacin and ciprofloxacin at 4 x MIC, were bactericidal (99.9% killing) for all strains after 12 h and 24 h. By contrast, amoxycillin, cefuroxime and ceftriaxone showed bactericidal activity after 24 h against all strains at 4, 8 and 4 x MIC, respectively. Against ten organisms with clarithromycin MICs of 0.03-4.0 mg/L, clarithromycin was bactericidal against seven strains at 8 x MIC after 24 h. Quinolones showed more rapid killing at lower concentrations and earlier time periods than did beta-lactams and clarithromycin.  (+info)

Mutations in the active site of penicillin-binding protein PBP2x from Streptococcus pneumoniae. Role in the specificity for beta-lactam antibiotics. (3/269)

Penicillin-binding protein 2x (PBP2x) isolated from clinical beta-lactam-resistant strains of Streptococcus pneumoniae (R-PBP2x) have a reduced affinity for beta-lactam antibiotics. Their transpeptidase domain carries numerous substitutions compared with homologous sequences from beta-lactam-sensitive streptococci (S-PBP2x). Comparison of R-PBP2x sequences suggested that the mutation Gln552 --> Glu is important for resistance development. Mutants selected in the laboratory with cephalosporins frequently contain a mutation Thr550 --> Ala. The high resolution structure of a complex between S-PBP2x* and cefuroxime revealed that Gln552 and Thr550, which belong to strand beta3, are in direct contact with the cephalosporin. We have studied the effect of alterations at positions 552 and 550 in soluble S-PBP2x (S-PBP2x*) expressed in Escherichia coli. Mutation Q552E lowered the acylation efficiency for both penicillin G and cefotaxime when compared with S-PBP2x*. We propose that the introduction of a negative charge in strand beta3 conflicts with the negative charge of the beta-lactam. Mutation T550A lowered the acylation efficiency of the protein for cefotaxime but not for penicillin G. The in vitro data presented here are in agreement with the distinct resistance profiles mediated by these mutations in vivo and underline their role as powerful resistance determinants.  (+info)

Clinical effectiveness of levofloxacin in patients with acute purulent exacerbations of chronic bronchitis: the relationship with in-vitro activity. (4/269)

The objective of this randomized, double-blind study was to compare the clinical efficacy of levofloxacin at two different dosages with that of cefuroxime axetil in patients with acute purulent exacerbations of chronic bronchitis and, in particular, to assess the impact of the susceptibility to levofloxacin on the clinical findings. In total, 124 evaluable patients were treated for 7 days with oral levofloxacin 250 mg or 500 mg od, or cefuroxime axetil 250 mg bd. Sputum cultures were monitored pre-treatment, and at 1 and 7 days after the end of treatment. The susceptibility of Streptococcus pneumoniae isolates was tested by agar dilution in Columbia blood agar and by disc diffusion, but all other isolates were tested solely by the disc diffusion method. A greater number of infections were eradicated by levofloxacin than by cefuroxime axetil: infections were eradicated in 68% of patients receiving the 500 mg dosage and in 63% of those taking 250 mg levofloxacin, whereas the eradication rate with the comparator drug was much lower (48%). Against all pre-treatment S. pneumoniae isolates (n = 39), the MICs of levofloxacin were between 0.25 and 2 mg/L (geometric mean 0.95 mg/L), similar to those of the post-treatment strains (n = 32; mean 1.11 mg/L). All except one of the S. pneumoniae isolates were susceptible to penicillin G (MIC < or = 0.06 mg/L), and the remaining isolate was inhibited by 0.5 mg/L of penicillin G, but was fully susceptible to levofloxacin. Some pretreatment strains of Pseudomonas aeruginosa were resistant to levofloxacin, but many more resistant strains were encountered afterwards. All strains of Moraxella catarrhalis and Haemophilus influenzae were highly susceptible to levofloxacin in the disc diffusion tests. All the antimicrobial agents used in the study were well tolerated: only two patients discontinued treatment because of adverse drug effects. The results of this study indicated that, although there were some failures in patients with S. pneumoniae and P. aeruginosa infections, resistance to levofloxacin did not emerge rapidly among strains of S. pneumoniae during therapy with levofloxacin, and that natural resistance among pneumococci, H. influenzae and M. catarrhalis was rare.  (+info)

Antimicrobial treatment of an experimental otitis media caused by a beta-lactamase positive isolate of Haemophilus influenzae. (5/269)

A gerbil model of otitis media induced by a beta-lactamase producing and non-serotypeable isolate of Haemophilus influenzae was used to assess the in-vivo efficacy of co-amoxiclav and cefuroxime at low (5 mg/kg) and high (20 mg/kg) doses. The MIC of the antibiotics tested against the pathogen was 1 mg/L (1/0.5 mg/L for co-amoxiclav). The organism was inoculated (+/-10(6) cfu) by transbullar challenge directly in the middle ear and antibiotic treatment was commenced 2 h post-inoculation and continued at 8 h intervals for three doses. Only high dose co-amoxiclav significantly reduced the number of culture-positive specimens as compared with untreated animals or with other treatment groups (91.7% as compared with 36.7% for high dose cefuroxime). The results obtained in any treatment group were related to middle ear antibiotic level/MIC. Antibiotic concentrations in the middle ear 90 min after administration were about 10% of serum levels at 15 min, probably related to a slight inflammatory response. Only after high dose co-amoxiclav did the concentration in the middle ear exceed the MIC by a factor of four. In otitis media with effusion, if indicated, antibiotics active in vitro should be administered in high doses and, to avoid side effects, probably in short courses.  (+info)

Risk factors for treatment outcome of suspected microbial keratitis. Ofloxacin Study Group. (6/269)

BACKGROUND: Primary treatment for suspected microbial keratitis is generally successful. Although risks such as contact lens use are well recognised as causative factors for microbial keratitis, little is known about the risk factors that influence treatment outcome. The present study evaluates the risk factors assessed at diagnosis as prognostic indicators of primary treatment failure. METHODS: Patients were prospectively enrolled in the ofloxacin treatment trial and data concerning symptoms, treatments, past and concurrent eye disease were collected along with the measurement of corneal ulcer size at the slit lamp. All patients were scraped for microbiological investigation, and treated with either ofloxacin (0. 3%) or standard therapy of fortified cefuroxime and gentamicin drops. Treatment success was complete healing of the ulcer with zero dimensions of the epithelial defect within 2 weeks of start of treatment. The important prognostic indicators were selected by comparison among those who failed treatment, had delayed healing, or were culture positive with other patients using univariate and stratified analysis. These were then used in a Poisson model for multiple regression analysis to estimate the relative risk of the main prognostic variables. RESULTS: Of the 118 patients enrolled in the study, 14 were identified as primary treatment failures, 17 had slow healing, and 15 indolent ulcers. There were 49 culture positive patients. The multivariate analysis identified that large culture positive ulcers in patients 60 years or older had 5.5 times the risk of primary treatment failure (p<0.001). Significant predictors of slow healing were previous ocular disease and a positive culture; significant predictors of indolent ulceration were previous ocular disease and steroid use at diagnosis; the main predictor of a culture positive result was ulcer size. CONCLUSIONS: Elderly patients with large ulcers were more likely to be culture positive, fail primary therapy, and require surgical intervention. A positive microbial culture provided prognostic information regardless of the organism isolated. However, this information was of less value for those with small ulcers and for younger patients.  (+info)

Treatment of community-acquired pneumonia in outpatients: randomized study of clarithromycin alone versus clarithromycin and cefuroxime. (7/269)

OBJECTIVE: To evaluate the efficacy of clarithromycin alone in comparison with the combination of clarithromycin and cefuroxime in the treatment of nonhospitalized patients with community-acquired pneumonia (CAP) in a Mediterranean population. METHODS: CAP was defined as the acute onset of fever (>38 degrees C) with pulmonary opacity on chest roentgenogram. The American Thoracic Society (ATS) criteria (1993) were used to decide on patient hospitalization. Ninety subjects, of whom 53 (59%) were men, with a mean age (+/-SD) of 38+/-15 years, were randomized: 45 received clarithromycin 500 mg b.i.d. orally for 14 days (CL group), and 45 received clarithromycin plus cefuroxime 500 mg b.i.d. orally for 7 days (CLCE group). Patients were monitored with clinical, radiological, and laboratory controls at 3 and 21 days. There were no significant differences between the two groups with regard to demographic, clinical, physical and laboratory data. RESULTS: The mean time to defervescence was 2.4+/-1.4 and 2.4+/-1.5 days, respectively. Chest roentgenogram clearance was complete in all cases, without statistically significant differences in the time to resolution between both arms. Side effects were mild (no significant differences between groups): 5 patients in the CL group and 3 in the CLCE group showed gastrointestinal symptoms. Two patients (2.2%), both in the CLCE group, needed hospital admission during follow-up, but all 90 patients showed an excellent outcome. A causative agent was determined in 25 cases (28%). Legionella pneumophila, Streptococcus pneumoniae, and Mycoplasma pneumoniae were the most frequent pathogens. CONCLUSION: Empirical treatment of outpatient CAP with clarithromycin can be considered adequate in the Mediterranean area, independently of the microbiological etiology. ATS criteria for admitting patients with CAP are appropriate in this population.  (+info)

Predicting susceptibility of Streptococcus pneumoniae to ceftriaxone and cefotaxime by cefuroxime and ceftizoxime disk diffusion testing. (8/269)

In this study, disk diffusion testing with ceftizoxime and cefuroxime was evaluated for use in predicting the susceptibility of Streptococcus pneumoniae to ceftriaxone and cefotaxime. Of the 194 isolates included in this study, 138 were susceptible, 34 were intermediate, and 22 were resistant to cefotaxime by MIC testing; 138 isolates were susceptible, 35 were intermediate, and 21 were resistant to ceftriaxone by MIC testing. A zone of inhibition around the cefuroxime disk of >/=32 mm correctly categorized 101 of 138 isolates as susceptible to cefotaxime and ceftriaxone. A zone of inhibition around the ceftizoxime disk of >/=26 mm correctly categorized 111 of 138 isolates as susceptible to cefotaxime and 114 of 138 as susceptible to ceftriaxone. We conclude that disk diffusion can separate S. pneumoniae isolates susceptible to ceftriaxone and cefotaxime from those that are not susceptible. Isolates not falling into the susceptible category by disk diffusion require additional testing to determine the MIC.  (+info)

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Product Name: Cefuroxime Axetil Tablets. Common Name: antibiotic. Strength: 500mg. Description:. Cefuroxime axetil is a second generation oral cephalosporin antibiotic. It is an acetoxyethyl ester prodrug of cefuroxime which is effective orally. The activity depends on in vivo hydrolysis and release of cefuroxime.. Indications and Usage:. Cefuroxime axetil tablet form of cefuroxime axetil is approved for a broad range of uses, including the treatment of the following infections:. Tonsillitis (tonsil infection) or pharyngitis ("strep throat") caused by Streptococcus pyogenes bacteria. ...
Conditions have been established for identification and quantification of cefuroxime axetil and cefuroxime by thin-layer chromatography and densitometry. Good separation of these compounds was achieved on silica gel by use of chloroform-ethyl acetate-glacial acetic acid-water, 4:4:4:1 (v/v), as mobile phase. UV densitometry was used to detect spots on chromatograms. Under these conditions the limits of detection for cefuroxime axetil and cefuroxime were 40 ng and 30 ng, respectively. Recoveries of cefuroxime axetil and cefuroxime were 99.93% and 97.94%, respectively. ...
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Synonyms for cefuroxime in Free Thesaurus. Antonyms for cefuroxime. 2 synonyms for cefuroxime: Ceftin, Zinacef. What are synonyms for cefuroxime?
74 of the 100 patients underwent challenges with oral cefuroxime axetil and intramuscular ceftriaxone: all tolerated the challenge. After about a month we repeated the skin tests with PPL, MDM, and the two cephalosporins administered (cefuroxime and ceftriaxone). 8 patients (10.8%) presented new sensitizations: 2 for MDM, 2 for PPL and MDM, 1 for cefuroxime, 1 for ceftriaxone, 1 for PPL and ceftriaxone, 1 for PPL, MDM, cefuroxime and ceftriaxone. 26 patients refused the double challenge and only underwent a tolerance to cefuroxime axetil test. In one of these the challenge was positive. The skin tests after a month with PPL, MDM, and the cephalosporin administered (cefuroxime) presented new sensitizations in only one patient (4.0%), for PPL. ...
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Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Werner on ceftin cefuroxime axetil: These are two antibiotics.The Cefuroxime is a cousin of penicillin. The germs they would likely kill, dose, frequency and side effects would differ.
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Pharmacodynamics: Cefuroxime is a β-lactam type antibiotic. More specifically, it is a second-generation cephalosporin. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal. Cefuroxime is effective against the following organisms: Aerobic Gram-positive Microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. Aerobic Gram-negative Microorganisms: Escherichia coli, Haemophilus influenzae (including beta-lactamase-producing strains), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (including beta-lactamase-producing strains), Neisseria gonorrhoeae (including beta-lactamase-producing strains). Spirochetes: Borrelia burgdorferi. Cefuroxime axetil is the prodrug. ...
This is a randomized, open-label, parallel group, multicenter study to determine the safety and effectiveness of 500 mg of levofloxacin (once daily for 5 - 7 days) compared with 250 mg of cefuroxime axetil (every 12 hours for 10 days) in adults with chronic bronchitis experiencing rapid onset of severe worsening of symptoms caused by bacteria. The study consists of 3 visits: one visit for screening and enrollment, and 2 visits for assessment of safety and effectiveness (one visit on Days 3 - 5 of the study and one visit [post-therapy] 5 - 7 days after the last dose of the study drug). The total duration of patient participation in the study is approximately 2 weeks. The primary efficacy assessment is the clinical response 5 - 7 days after the last dose of study drug, (categorized as cured, improved, or failed) based upon changes in signs and symptoms. Safety evaluations (incidence of adverse events, physical examination, laboratory tests) are performed throughout the study. The study hypothesis ...
Cefuroxime Axetil is the name of the medication. It comes in the form of a tablet, and should be taken by mouth. It belongs to a class of medications called Cephalosporin Antibiotic.
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Available by prescription, cefuroxime axetil is a medication used to treat bacterial infections. This eMedTV page takes an in-depth look at the medicine, including information on how it works, tips for when and how to use it, and potential side effects.
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CEFTIN is a semisynthetic, broad-spectrum cephalosporin antibiotic for oral administration Ceftin 500mg uses ceftinex 300 mg ne ilacı Pfizer admitted no wrongdoing and said the FDA approved its advertising and promotional materials. Ear infections. It is used to treat infections caused by bacteria. It is also given before some surgical operations, to prevent an infection from occurring Cefuroxime Axetil 500mg Tablets Unfortunately our full catalog may not be displayed in your state. If you contact our Customer Support by one of the methods below, we will be able to assist you in locating the product you are looking for Cefuroxime (Ceftin, Zinacef) is an antibiotic used to treat infections of the middle ear, sinuses, skin, tonsils, and throat, and to treat laryngitis, bronchitis, pneumonia, urinary tract infections, gonorrhea, COPD, and early Lyme disease 500 mg (of cefuroxime) Ceftin (GlaxoSmithKline) Oral: Tablets, film-coated: 500 mg (of cefuroxime) Cefuroxime Axetil Tablets (Available from ...
Drugs ZINNAT have composition Cefuroxime, indicated for the treatment of low, upper respiratory tract infections: skin and soft tissue, Gonorrhoea
Cefuroxime is an enteral second-generation cephalosporin antibiotic. It was discovered by the Glaxo, now GlaxoSmithKline and first marketed in 1978 as Zinacef. It received approval from the U.S. Food and Drug Administration in October 1983.. Cefuroxime is used to treat a wide variety of bacterial infections. This medication is known as a cephalosporin antibiotic. It works by stopping the growth of bacteria.. This antibiotic treats only bacterial infections. It will not work for viral infections (e.g., common cold, flu). Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.. ...
Cefuroxime. Molecular model of the antibiotic drug cefuroxime (C16.H16.N4.O8.S). This is a second-generation cephalosporin antibiotic. It is used against a wide range of diseases, including pneumonia, gonorrhea and Lyme disease. Atoms are represented as spheres and are colour-coded: carbon (grey), hydrogen (white), nitrogen (blue), oxygen (red) and sulphur (yellow). Illustration. - Stock Image F017/0253
Cefuroxime. Molecular model of the antibiotic drug cefuroxime (C16.H16.N4.O8.S). This is a second-generation cephalosporin antibiotic. It is used against a wide range of diseases, including pneumonia, gonorrhea and Lyme disease. Atoms are represented as spheres and are colour-coded: carbon (grey), hydrogen (white), nitrogen (blue), oxygen (red) and sulphur (yellow). Illustration. - Stock Image F016/9630
Cefuroxime generic is used for treating bacterial infections. Order more than 20 tablets and save $63.18. Find side effects and interactions of Cefuroxime too.
... ! Cefuroxime is used for treating bacterial infections (sinus, skin, lung, urinary tract, ear, and throat). It works by interfering with the formation of the bacterias cell wall so that the wall ruptures, resulting in the death of the bacteria.
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To obtain a control group from the same geographical area, each patient was asked if she or he had a family member or friend who was within 5 years of her or his age and who was without a history of Lyme borreliosis. These persons were approached by a short written explanation of the investigation, containing also a request for their participation. We assumed that we will be able to get a corresponding control person not for all but for approximately 80-90% of patients ...
Second-generation cephalosporin for oral and injection or parenteral administration. Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Voropaeva 1982, Amiraslanova 1985, Nakamura 1987). No adverse effects reported in breasted infants (Benyamini 2005). Intravenously administered Cefuroxime salt is not orally absorbed. Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant. Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.
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Easy to read patient leaflet for Ceftin (Cefuroxime Tablets). Includes indications, proper use, special instructions, precautions, and possible side effects.
To the Editor: Drug Prescribing in Renal Failure by Bennett and colleagues (1) possibly contains a misprint. This excellent reference provides dosage recommendations for various drugs when prescribed for patients with differing degrees of renal dysfunction.. For patients with an estimated glomerular filtration rate of less than 10 mL/min, Bennett and colleagues recommend 5%-10% of the usual intravenous cefuroxime dosage. If the usual dose of 750 mg is given every 8 hours, patients will receive 112 to 225 mg daily. Ten percent of the dosage for life-threatening infections (1.5 g every 6 hours) provides 600 mg daily. In contrast, the ...
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4.8 Undesirable Effects. Adverse drug reactions are very rare (,1/10,000) and are generally mild and transient in nature.. The frequency categories assigned to the adverse reactions below are estimates, as for most reactions suitable data for calculating incidence are not available. In addition the incidence of adverse reactions associated with cefuroxime sodium may vary according to the indication.. Data from clinical trials were used to determine the frequency of very common to rare undesirable effects. The frequencies assigned to all other undesirable effects (i.e., those occurring at ,1/1000) were mainly determined using post-marketing data, and refer to a reporting rate rather than a true frequency. The following convention has been used for the classification of frequency: very common 1/10, common 1/100 and ,1/10, uncommon 1/1000 and ,1/100, rare 1/10,000 and ,1/1000, very rare ,1/10,000. Infections and infestations. Rare: Candida overgrowth from prolonged use.. Blood and lymphatic system ...
4.8 Undesirable Effects. Adverse drug reactions are very rare (,1/10,000) and are generally mild and transient in nature.. The frequency categories assigned to the adverse reactions below are estimates, as for most reactions suitable data for calculating incidence are not available. In addition the incidence of adverse reactions associated with cefuroxime sodium may vary according to the indication.. Data from clinical trials were used to determine the frequency of very common to rare undesirable effects. The frequencies assigned to all other undesirable effects (i.e., those occurring at ,1/1000) were mainly determined using post-marketing data, and refer to a reporting rate rather than a true frequency. The following convention has been used for the classification of frequency: very common 1/10, common 1/100 and ,1/10, uncommon 1/1000 and ,1/100, rare 1/10,000 and ,1/1000, very rare ,1/10,000. Infections and infestations. Rare: Candida overgrowth from prolonged use.. Blood and lymphatic system ...
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My 3 and a half year old |b|daughter is running fever|/b| which goes till 39.6 degree C since last 5 days. She also has cough and running nose. Her x-ray, blood and urine tests are normal. After taking paracetamol or suppository, fever returns to normal. She is taking azithromycin - once a day and zinnat(cefuroxime axetil) - twice a day, as antibiotics. What could be the reason for persistent fever? Last month she had conjunctivitis in her left eye and it lasted for 2 days after taking topical solution. 15 days back she had viral fever but it lasted for two days and was not as high as it is now. She had completed the course of antibiotics then. We are very worried for her, please advice us accordingly.
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Evaluation of efficacy and safety of cefuroxime axetil (CXM-AX) in the treatment of infections in the dentistry and oral surgery. (1989 ...
Pill with imprint RX 751 is Blue, Elliptical / Oval and has been identified as Cefuroxime axetil 250 mg. It is supplied by UDL Laboratories Inc.
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Bactericidal cepholosporin antibiotic which is resistant to most β-lactamases and is active against a wide range of Gram-positive and Gram-negative organisms.
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This medication is typically used twice a day. However, your doctor or pharmacist may have suggested a different schedule that is more appropriate for you. Generally, a treatment with this medication lasts several days. Take it for the entire time prescribed in order to achieve the medications full benefit. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. It is not advisable to chew or crush this medication since it has an unpleasant taste. If you forget a dose, take it as soon as you remember -- unless it is almost time for your next dose. In that case, skip the missed dose. Do not double the next dose to catch up. This medication is more effective if taken with food. Always take it with a meal or a snack. ...
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OBJECTIVES: Penicillin-susceptible Staphylococcus aureus isolates account for a fifth of cases of S. aureus bacteraemia (SAB) in Denmark, but little is known about treatment outcomes with penicillins or other antimicrobials. Here we compare penicillin, dicloxacillin and cefuroxime as definitive treatments in relation to 30 day mortality. METHODS: A retrospective chart review of 588 penicillin-susceptible S. aureus cases at five centres from January 1995 to December 2010. Data on demographics, antimicrobial treatment, clinical signs and symptoms, and mortality at day 30 were collected. Hazard ratios (HRs) with 95% CIs associated with mortality were modelled using propensity-score-adjusted Cox proportional hazards regression analysis. Propensity-score-matched case-control studies were carried out. RESULTS: Definitive therapy with cefuroxime was associated with an increased risk of 30 day mortality compared with penicillin (adjusted HR 2.54, 95% CI 1.49-4.32). Other variables that were ...
SAHP recommends amoxicillin / clavulanate, amoxicillin, cefpooxime proxetil, cefuroxime axetil, cefdinir, β-lactam allergic# TMP/SMX (trimethoprim / sulfamethoxazole), doxycycline, azithromycin, clarithromycin, erythromycin and telithromycin for the Group 1 patients. Calculated bacteriologic and clinical efficacies of amoxicillin / clavulanate is the highest at 97-99% and 90-91% respectively. The corresponding efficacies of telithromycin are 73% and 77%. The guidelines also suggest alternatives in case the therapy does not show desired results or worsens the symptoms during 72 hours. For instance, if amoxicillin or doxycycline therapy fails, switch to gatifloxacin, levofloxacin and moxifloxacin. If cefuroxime axetil does not improve the symptoms, switch to ceftriaxone ...
Bone and wound fluid concentrations of cephalosporins. Oral cefadroxil and parenteral cefuroxime compared in 52 patients with a trochanteric fracture. ...
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Chemotherapeutic agents in periodontics and their detailed description. Applications of penicillins (Amoxicillin, ampicillin, Bacampicillin), cephalosporins (Cefuroxime, Cefuroxime axetil, Cefprozil, Cefmatazole, Loracarbef) , monobactams, Tetracyclines (doxycycline), Macrolides, Clindamycin, Sulfonamides and Trimethoprim.
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PO Uncomplicated UTI 125 mg twice daily. Respiratory tract infections 250-500 mg twice daily. Uncomplicated gonorrhea W/ oral probenecid: 1 g as a single dose. IV Meningitis 3 g 8 hrly. IM Gonorrhea W/ oral probenecid: 1.5 g as a single dose. IV/IM Surgical prophylaxis 1.5 g IV per-op, then 750 mg IM 8 hrly for up to 24-48 hr. Susceptible infections750 mg 8 hrly, up to 1.5 g 6-8 hrly for severe infections ...
Oral therapy (doxycycline, 100 mg PO bid; amoxicillin, 500 mg PO tid; or cefuroxime axetil, 500 mg PO bid for 10-21 days) is used for early localized or disseminated disease without neurologic or cardiac involvement. The same agents, given for 28 days, are recommended for late Lyme disease. ...
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Diverticulitis diverticulosis is a condition in which the diverticulum or diverticula rupture in the colon causing infection. Cefuroxime, Oral Tablet Cefuroxime Ceftin is an oral drug used to treat bacterial infections. There are two forms of this type of ear Cephalexin should not be combined with BCG or typhoid vaccine unless there are no other options. Understand Immunotherapy Painful Knees?. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. Your doctor may adjust your dose of metformin to reduce this risk. Does Keflex interact with other medications? Infections can range from mild to severe Email addresses will not be shared with third parties. ...
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... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...
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If an infection develops, a number of antibiotics are effective, including doxycycline, amoxicillin, and cefuroxime. Standard ... cefuroxime axetil, and azithromycin. Individuals with early disseminated or late infection may have symptomatic cardiac disease ... cefuroxime axetil, intravenous and intramuscular penicillin and intravenous ceftriaxone. The mechanism of tick transmission was ...
Rudnicka, L; Szymańska, E; Walecka, I; Słowińska, M (2000). "Long-term cefuroxime axetil in subacute cutaneous lupus ... Improvement of psoriasis after antibiotic therapy with cefuroxime axetil. J Eur Acad Dermatol Venereol. 2009, doi:10.1111/j. ... Improvement of psoriasis after antibiotic therapy with cefuroxime axetil. J Eur Acad Dermatol Venereol. 2009, doi:10.1111/j. ...
Cefuroxime was the first cephalosporin to incorporate this side chain. Another very important group in the second generation is ...
In meningitis, cefotaxime crosses the blood-brain barrier better than cefuroxime. As a β-lactam antibiotic in the third- ...
"Aprokam cefuroxime 50mg powder for solution for injection - Summary of Product Characteristics (SPC) - (eMC)". Retrieved 3 ... In the UK, Aprokam cefuroxime has been approved for use in intracameral injections. Intracameral injection of recombinant ...
Nadelman RB, Luger SW, Frank E, Wisniewski M, Collins JJ, Wormser GP (1992). "Comparison of cefuroxime axetil and doxycycline ... March 1995). "Comparison of cefuroxime axetil and doxycycline in treatment of patients with early Lyme disease associated with ...
The type strain is resistant to ampicillin, cefuroxime, cloxacillin, erythromycin, penicillin and polymyxin. Sensitive to ...
Glaxo drugs that sold well included the Fortum (ceftazidime) and Zinnat (cefuroxime axetil) antibiotics. He married in 1952; ...
These include ampicillin, chloramphenicol, amoxicillin-clavulanic acid, cefamandole, cefuroxime, cefotaxime, tetracycline, ...
Rong-geng Wang; Liu, Cheng-ping; Zhu, Kun-peng; Du, Hai-lin; Liu, Lie-yi (2004). "Side chain of cefuroxime: (Z)-2-methoxyimino- ... Reaction of 2-acetylfuran with aqueous sodium nitrite gave 2-furanyloxoacetic acid, an intermediate to Cefuroxime, a second- ... and is used in the production of the generic cephalophosphorin antibiotic cefuroxime. 2-Acetylfuran was prepared by Ashina in ...
Müller R, Böttger C, Wichmann G (2003). "Suitability of cefotiam and cefuroxime axetil for the perioperative short-term ...
... cefuroxime (Ceftin), cefadroxil (Duricef), cephalexin (Keflex), and others. Imipenem/cilastatin has the ability to kill a wide ...
Cefuroxime and ambroxol". Arzneimittel-Forschung. 50 (8): 700-11. doi:10.1055/s-0031-1300276. PMID 10994153. ...
Cefuroxime is generally effective in the eradication of streptococci from the nasopharynx British National Formulary (45 ed.). ...
... cefuroxime, and trimethoprim. "Mastitis in Cattle: Overview". The Merck Veterinary Manual. 2006. Retrieved 2007-06-05. Type ...
... cefuroxime, and trimethoprim. The genome of C. diphtheriae consists of a single circular chromosome of 2.5 Mbp, with no ...
... cefuroxime, and trimethoprim. "Bovine Cystitis and Pyelonephritis". The Merck Veterinary Manual. 2006. Retrieved 2007-06-05. ...
The review showed high-certainty evidence that antibiotic injections in the eye with cefuroxime at the end of surgery lowers ... cefuroxime or penicillin) probably lowers the chance of endophthalmitis compared with injections or eye drops alone. Separate ... and an intracameral cefuroxime injection with topical levofloxacin resulted in a risk reduction of developing endophthalmitis ...
... cefuroxime, and loracarbef". J. Clin. Microbiol. 32 (2): 559-62. PMC 263078 . PMID 8150976. RxList.com - Loracarbef. ...
Drugs linked to HSP, usually as an idiosyncratic reaction, include the antibiotics vancomycin and cefuroxime, ACE inhibitors ...
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When Staphylococcus aureus was tested against cephalexin and cefuroxime, most were susceptible at 37 degree C whereas all were ... Methicillin-resistant staphylococci were tested for susceptibility to cephradine, cephaloridine, cephalexin, and cefuroxime and ...
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Effectiveness of penicillin, dicloxacillin and cefuroxime for penicillin-susceptible Staphylococcus aureus bacteraemia. * ... Here we compare penicillin, dicloxacillin and cefuroxime as definitive treatments in relation to 30 day mortality. METHODS: A ... RESULTS: Definitive therapy with cefuroxime was associated with an increased risk of 30 day mortality compared with penicillin ... Propensity-score-matched case-control studies confirmed an increased risk of 30 day mortality: cefuroxime treatment (39%) ...
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Cefuroxime. References[edit]. *^ Walter Sneader (2005-06-23). Drug Discovery: A History. John Wiley, Chichester, UK. ISBN 0-471 ... "Cefuroxime Axetil Monograph for Professionals". Drugs.com. Retrieved 2018-04-22.. *^ "Brands". Gsksource.com. 2018-03-22. ... It is an acetoxyethyl ester prodrug of cefuroxime which is effective orally.[1] The activity depends on in vivo hydrolysis and ... Cefuroxime axetil, sold under the brand name Zinnat among others, is a second generation oral cephalosporin antibiotic. ...
Cefuroxime: learn about side effects, dosage, special precautions, and more on MedlinePlus ... To treat gonorrhea, cefuroxime is taken as a single dose, and to treat Lyme disease, cefuroxime is taken every 12 hours for 20 ... Take cefuroxime until you finish the prescription, even if you feel better. If you stop taking cefuroxime too soon or skip ... Before taking cefuroxime,. *tell your doctor and pharmacist if you are allergic to cefuroxime; other cephalosporin antibiotics ...
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Learn about the potential side effects of cefuroxime. Includes common and rare side effects information for consumers and ... Ceftin (cefuroxime)." Glaxo Wellcome, Research Triangle Park, NC. 10. Abramowicz M, Aaron H "Cefuroxime axetil." Med Lett Drugs ... Applies to cefuroxime: injectable powder for injection, intravenous solution, oral powder for reconstitution, oral tablet ... Zinacef (cefuroxime)." Glaxo Wellcome, Research Triangle Park, NC. 7. Yangco BG, Lowe J, Nolen TM, et al "A multicenter trial ...
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About this substance This section provides an overview of the volume in which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here.. The use information is displayed per substance life cycle stage (consumer, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites or in manufacturing). The information is aggregated from REACH registered dossiers provided by industry.. For a detailed overview on identified uses and environmental releases, please consult the registered substance dossier.. Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety ...
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  • Arthur M, McAdoo M, Guerra J, Maloney R, McCluskey D, Giguere G, Gomez G, Collins JJ (1996) Clinical comparison of cefuroxime axetil with cefixime in the treatment of acute bronchitis. (thefreedictionary.com)
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