Ceftazidime. Medical search

Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.

A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.

Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.

A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.

Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).

Substances that reduce the growth or reproduction of BACTERIA.

A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.

Non-susceptibility of an organism to the action of the cephalosporins.

Semisynthetic broad-spectrum cephalosporin.

Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.

Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.

A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.

Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.

Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotics. They lack the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized.

Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.

Infections with bacteria of the genus PSEUDOMONAS.

Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.

Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.

A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)

A disease of humans and animals that resembles GLANDERS. It is caused by BURKHOLDERIA PSEUDOMALLEI and may range from a dormant infection to a condition that causes multiple abscesses, pneumonia, and bacteremia.

Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.

Bicyclic bridged compounds that contain a nitrogen which has three bonds. The nomenclature indicates the number of atoms in each path around the rings, such as [2.2.2] for three equal length paths. Some members are TROPANES and BETA LACTAMS.

Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.

The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.

An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.

A species of gram-negative, aerobic bacteria that causes MELIOIDOSIS. It has been isolated from soil and water in tropical regions, particularly Southeast Asia.

Infections with bacteria of the family ENTEROBACTERIACEAE.

Infections with bacteria of the genus KLEBSIELLA.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in water, sewage, soil, meat, hospital environments, and on the skin and in the intestinal tract of man and animals as a commensal.

Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLES to the PULMONARY ALVEOLI. The affected areas become filled with exudate that forms consolidated patches.

Infections by bacteria, general or unspecified.

Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.

Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.

A broad-spectrum antimicrobial carboxyfluoroquinoline.

Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.

Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.

Method of measuring the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy. It is used to monitor the therapy in BACTERIAL ENDOCARDITIS; OSTEOMYELITIS and other serious bacterial infections. As commonly performed, the test is a variation of the broth dilution test. This test needs to be distinguished from testing of the naturally occurring BLOOD BACTERICIDAL ACTIVITY.

Therapy with two or more separate preparations given for a combined effect.

A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).

A group of beta-lactam antibiotics in which the sulfur atom in the thiazolidine ring of the penicillin molecule is replaced by a carbon atom. THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain.

One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.

The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.

The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.

Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.

The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.

Bacteria which retain the crystal violet stain when treated by Gram's method.

An abnormal elevation of body temperature, usually as a result of a pathologic process.

Use of any infusion therapy on an ambulatory, outpatient, or other non-institutionalized basis.

Gram-negative gas-producing rods found in feces of humans and other animals, sewage, soil, water, and dairy products.

Suppurative inflammation of the tissues of the internal structures of the eye frequently associated with an infection.

A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.

An antibiotic derived from penicillin similar to CARBENICILLIN in action.

The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.

Injections made into a vein for therapeutic or experimental purposes.

A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)

A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

The quality of not being miscible with another given substance without a chemical change. One drug is not of suitable composition to be combined or mixed with another agent or substance. The incompatibility usually results in an undesirable reaction, including chemical alteration or destruction. (Dorland, 27th ed; Stedman, 25th ed)

A pyridinium-substituted semisynthetic, broad-spectrum antibacterial used especially for Pseudomonas infections in debilitated patients.

Any infection which a patient contracts in a health-care institution.

Clindamycin suppresses endotoxin released by ceftazidime-treated Escherichia coli O55:B5 and subsequent production of tumor necrosis factor alpha and interleukin-1 beta. (1/736)

Treatment of septicemia caused by Escherichia coli with ceftazidime (CAZ) may be associated with the development of septic shock due to the release of bacterial lipopolysaccharide. We examined the suppressive effect of clindamycin (CLDM) on CAZ-induced release of endotoxin by cultured E. coli and the subsequent production of inflammatory cytokines (tumor necrosis factor alpha [TNF-alpha] and interleukin-1 beta [IL-1 beta]). E. coli ATCC 12014 was incubated in inactivated horse serum with or without CLDM for 1, 4, or 18 h, followed by the addition of CAZ and collection of the culture supernatant at 0, 1, and 2 h. The concentration of endotoxin in each sample was measured by a chromogenic Limulus test. Another portion of the culture supernatant was added to THP-1 cell culture and incubated for 4 h, and the concentrations of TNF-alpha and IL-1 beta in the supernatant were measured by an enzyme-linked immunosorbent assay. In the control group (no CLDM), CAZ administration resulted in significant increases in endotoxin, TNF-alpha, and IL-1 beta concentrations. Pretreatment of E. coli with CLDM for 4 or 18 h before the addition of CAZ significantly suppressed the concentrations of endotoxin, TNF-alpha, and IL-1 beta in a time-dependent manner. In addition, CAZ treatment transformed E. coli from rodshaped bacteria to filament-like structures, as determined by electron microscopy, while pretreatment with CLDM prevented these morphological changes. Our in vitro studies showed that CAZ-induced release of large quantities of endotoxin by E. coli could be suppressed by prior administration of CLDM. (+info)

Molecular basis of AmpC hyperproduction in clinical isolates of Escherichia coli. (2/736)

DNA sequencing data showed that five clinical isolates of Escherichia coli with reduced susceptibility to ceftazidime, ceftriaxone, and cefotaxime contain an ampC gene that is preceded by a strong promoter. Transcription from the strong promoter was 8- to 18-fold higher than that from the promoter from a susceptible isolate. RNA studies showed that mRNA stability does not play a role in the control of AmpC synthesis. (+info)

Laboratory mutants of OXA-10 beta-lactamase giving ceftazidime resistance in Pseudomonas aeruginosa. (3/736)

Several extended-spectrum beta-lactamases (ESBLs) belonging to molecular Class D have been described from Pseudomonas aeruginosa isolates collected in Turkey. Four of these, OXA-11, -14, -16 and -17, are derivatives of OXA-10 beta-lactamase. We tried to select similar mutants in vitro from OXA-10-producing transconjugants of P. aeruginosa, using a multistep method on ceftazidime-containing agars. Forty-four such mutants were obtained; all had increased resistance to ceftriaxone, cefsulodin, cefepime, cefpirome, latamoxef, aztreonam and, especially, ceftazidime whereas MICs of piperacillin, carbenicillin, cefotaxime, cefoperazone and carbapenems were little altered. Genes related to blaOXA-10 were sequenced from five mutants. One mutant enzyme had aspartate instead of glycine at position 157, and corresponded exactly to natural OXA-14 beta-lactamase. Another mutant strain appeared to have both OXA-14 and a new pI 6.2 enzyme, designated OXA-M102, with serine instead of alanine at position 124 and aspartate instead of glycine at position 157. This latter variant resembled natural OXA-16 enzyme, which has threonine at position 124 and aspartate at position 157. The remaining three mutant enzymes differed from any so far found in wild-type isolates. Two had leucine replacing tryptophan at position 154 (this enzyme was named OXA-M101) while the third (OXA-M103) had a pI of 7.6, and had lysine instead of asparagine at position 143. A different mutation at this position was previously found in OXA-11, a wild-type OXA-10 mutant. Thus, some of the ESBL mutants selected (OXA-14 and OXA-M102) correspond exactly or almost exactly to ESBLs found in wild-types, whereas others (OXA-M101 and OXA-M103) were totally new. (+info)

Piperacillin/tazobactam plus tobramycin versus ceftazidime plus tobramycin for the treatment of patients with nosocomial lower respiratory tract infection. Piperacillin/tazobactam Nosocomial Pneumonia Study Group. (4/736)

An open-label, randomized, comparative, multi-centre study was conducted at 25 centres in the USA and Canada to compare the safety and efficacy of piperacillin/tazobactam plus tobramycin with ceftazidime plus tobramycin in patients with lower respiratory tract infections. Piperacillin/tazobactam (3 g/375 mg) every 4 h or ceftazidime (2 g) every 8 h were administered i.v. for a minimum of 5 days. Tobramycin (5 mg/kg/day) given in divided doses every 8 h was administered to all patients. Patients with Pseudomonas aeruginosa isolated from respiratory secretions at baseline were to continue tobramycin for the duration of the study. Tobramycin could be discontinued in other patients after the baseline culture results were known. A total of 300 patients was randomized, 155 into the piperacillin/tazobactam group and 145 into the ceftazidime group. Of these, 136 patients (78 in the piperacillin/tazobactam group and 58 in the ceftazidime group) were considered clinically evaluable. Both groups were comparable for age, sex, duration of treatment and other demographic features. The clinical success rate in evaluable patients was significantly greater (P = 0.006) in the piperacillin/tazobactam treatment group (58/78; 74%) than in the ceftazidime group (29/58; 50%). Eradication of the baseline pathogen was significantly greater (P = 0.003) in the piperacillin/tazobactam group (66%) than in the ceftazidime group (38%). The clinical and bacteriological responses of those patients with nosocomial pneumonia were similar to the overall results. Twelve (7.7%) piperacillin/tazobactam-treated patients and 24 (17%) ceftazidime-treated patients died during the study (P = 0.03). Seven of the 24 deaths in the ceftazidime treatment group but only one of the 12 deaths in the piperacillin/tazobactam treatment group were directly related to failure to control infection. The majority of adverse events were thought by the investigator to be attributable to the patients' underlying disease and not drug related. In this study, piperacillin/tazobactam plus tobramycin was shown to be more effective and as safe as ceftazidime plus tobramycin in the treatment of patients with nosocomial LRTI. (+info)

In-vitro susceptibility of 1982 respiratory tract pathogens and 1921 urinary tract pathogens against 19 antimicrobial agents: a Canadian multicentre study. Canadian Antimicrobial Study Group. (5/736)

A total of 3903 pathogens from 48 Canadian medical centres were tested against 19 antimicrobial agents. Five agents showed activity against > or = 90% of all 1982 respiratory tract pathogens tested (ciprofloxacin, 90%; cefoperazone, 91%; ticarcillin/clavulanate, 92%; ceftazidime and imipenem, 93% each). Nine agents had > or = 90% activity against Enterobacteriaceae from respiratory tract infection (cefotaxime and ticarcillin/clavulanate, 90% each; aztreonam, ceftizoxime and ceftriaxone, 91% each; ceftazidime, 93%; ciprofloxacin, 97%; imipenem and netilmicin, 98% each). Similarly, five agents had activity against > or = 90% of all 1921 urinary tract pathogens tested (ciprofloxacin and ticarcillin/clavulanate, 90% each; cefoperazone and netilmicin, 91% each; imipenem, 99%). Nine agents had > or = 95% activity against Enterobacteriaceae from urinary tract infection (ciprofloxacin, 95%; cefotetan, 97%; aztreonam, cefotaxime, ceftazidime, ceftizoxime, ceftriaxone and netilmicin, 98% each; imipenem, 99%). Seventeen agents had activity against > or = 95% of Staphylococcus aureus strains. Susceptibility of Pseudomonas aeruginosa isolates ranged from 2% to 91%. (+info)

Antibiotic dosing issues in lower respiratory tract infection: population-derived area under inhibitory curve is predictive of efficacy. (6/736)

Several lower respiratory tract infection (LRTI) trials have documented a correlation between clinical response and area under the inhibitory curve (24 h AUC/MIC; AUIC). The AUIC values in these studies were based on measured MICs and measured serum concentrations. This study evaluates AUIC estimates made using population pharmacokinetic parameters, and MICs from an automated microbiological susceptibility testing system. A computer database review over 2 years yielded 81 patients at Millard Fillmore Hospital with a culture-documented gram-negative LRTI who had been treated with piperacillin and an aminoglycoside, ceftazidime, ciprofloxacin or imipenem. Their AUIC values were estimated using renal function, drug dosages and MIC values. Outcome groups (clinical and microbiological cures and failures) were related to the AUIC values using Kruskal-Wallis ANOVA, linear regression and classification and regression tree (CART) analysis. A significant breakpoint for clinical cures was an AUIC value at least 72 SIT(-1) x 24 h (inverse serum inhibitory titre integrated over time). All antibiotics performed significantly better above this value than below it. Clinical cure was well described by a Hill-type equation. Within the piperacillin/aminoglycoside regimen, most of the activity came from the piperacillin, which had a higher overall AUIC value than the aminoglycoside. AUIC estimations based upon MIC values derived from the automated susceptibility testing method differed from NCCLS breakpoint data and from tube dilution derived values in this hospital by as much as three tube dilutions. These automated methods probably overestimated the MIC values of extremely susceptible organisms. The lack of precise MIC estimates in automated clinical microbiology methods impairs the use of AUIC to prospectively optimize microbiological outcome. Even ignoring this limitation and using the values as they are reported, the results of this analysis suggest that AUIC targets between 72 and 275 SIT(-1) x 24 h are useful in predicting clinical outcome. (+info)

A resuscitated case from asphyxia by large bronchial cast. (7/736)

A 62-year-old woman with bronchiectasis suffered from asphyxia due to a large bronchial cast that obstructed the bronchial tree. Immediate bronchoscopic suction of a bronchial cast of 17 cm in length through the intubated tube relieved the patients without any complications. Large bronchial casts appear to be rare in this century but it should be considered in patients with acute exacerbation of excessive sputa not only in patients with asthma or allergy but also in patients with respiratory tract infection. (+info)

Survey of extended-spectrum beta-lactamases in clinical isolates of Escherichia coli and Klebsiella pneumoniae: prevalence of TEM-52 in Korea. (8/736)

Two hundred ninety isolates of Escherichia coli were investigated for the production of extended-spectrum beta-lactamases (ESBLs). Fourteen (4.8%) of the 290 strains were found to produce ESBLs. Each of the 14 strains produced one or two ESBLs, as follows: 10 strains produced TEM-52, 1 strain produced SHV-2a, 1 strain produced SHV-12, 1 strain produced a CMY-1-like enzyme, and 1 strain expressed SHV-2a and a CMY-1-like enzyme. Another two strains for which the MICs of ceftazidime and cefoxitin were high, were probable AmpC enzyme hyperproducers. Because of the high prevalence of TEM-52 in E. coli isolates, we further investigated the TEM-type ESBLs produced by Klebsiella pneumoniae in order to observe the distribution of TEM-52 enzymes among Enterobacteriaceae in Korea. All TEM enzymes produced by 12 strains of K. pneumoniae were identified as TEM-52. To evaluate the genetic relatedness among the organisms, ribotyping of TEM-52-producing E. coli and K. pneumoniae was performed. The ribotyping profiles of the organisms showed similar but clearly different patterns. In conclusion, TEM-52 is the most prevalent TEM-type ESBL in Korea. (+info)

Richards DM, Brogden RN (February 1985). "Ceftazidime. A review of its antibacterial activity, pharmacokinetic properties and ... and ceftazidime for bacterial infections, zidovudine for HIV infection, valacyclovir for herpes virus infections, albendazole ...

https://en.wikipedia.org/wiki/GlaxoSmithKline

Ceftazidime "Cefotaxime". Merriam-Webster Dictionary. Retrieved 21 January 2016. "Cefotaxime (Claforan) Use During Pregnancy". ...

https://en.wikipedia.org/wiki/Cefotaxime

Hughes, SP; McCarthy, ID; Fleming, RM; Anderson, FM; Dash, CH (1984). "Extraction of ceftazidime in bone". J Antimicrob ...

https://en.wikipedia.org/wiki/Sean_P._F._Hughes

The antibiotic of choice is ceftazidime. While various antibiotics are active in vitro (e.g., chloramphenicol, doxycycline, co- ... "Halving of mortality of severe melioidosis by ceftazidime". Lancet. 2 (8665): 697-701. doi:10.1016/S0140-6736(89)90768-X. PMID ...

https://en.wikipedia.org/wiki/Burkholderia_pseudomallei

InChI=1S/C20H22N4O10S/c1-9(25)33-10(2)34-19(28)15-11(7-32-20(21)29)8-35-18-14(17(27)24(15)18)22-16(26)13(23-30-3)12-5-4-6-31-12/h4-6,10,14,18H,7-8H2,1-3H3,(H2,21,29)(H,22,26)/b23-13-/t10?,14-,18-/m1/ ...

https://en.wikipedia.org/wiki/Cefuroxime_axetil

The production of benzylpenicillin involves fermentation, recovery and purification of the penicillin.[10] The fermentation process of the production of benzylpencillin is about obtaining the product. The presence of the product in solution inhibits the reaction and reduces the product rate and yield. Thus, in order to obtain the most product and increase the rate of reaction the product, would be continuously extracted out.[11] This is done by having the mold with either glucose, sucrose, lactose, startch, or detrin, nitrate, ammonium salt, corn steep liquor, peptone, meat or yeast extract, and little amounts of inorganic salts.[12] The recovery of the benzylpencillin is the most important part of the production process because it affects the purification steps if done wrong.[10] There are many different types of techniques to recover benzyl penicillin, aqueous two-phase extraction, liquid membrane extraction, microfiltration technique, and solvent subulation[10] Extraction is more commonly ...

https://en.wikipedia.org/wiki/Benzylpenicillin

... , sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections.[1] Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax.[1] It is given by injection into a vein.[1] Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection.[1] Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis.[1] Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem.[1] Use in pregnancy appears to be safe.[1] It is in the carbapenem family of medications.[1] Meropenem usually results in bacterial death through blocking their ability to make a cell wall.[1] It is more resistant to breakdown β-lactamase producing bacteria.[1] Meropenem was patented in 1983.[2] It was approved for medical use in the United States in 1996.[1] It is on the World Health ...

https://en.wikipedia.org/wiki/Meropenem

InChI=1S/C14H15N5O5S2/c1-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24-2)6-4-26-14(15)16-6/h4,8,12H,3H2,1-2H3,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/ ...

https://en.wikipedia.org/wiki/Cefetamet

Bonow RO, Carabello BA, Kanu C, et al. (August 2006). "ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons". Circulation. 114 (5): e84-231. doi:10.1161/CIRCULATIONAHA.106.176857. PMID 16880336 ...

https://en.wikipedia.org/wiki/Nafcillin

Penicillin V is sometimes used in the treatment of odontogenic infections.. It is less active than benzylpenicillin (penicillin G) against Gram-negative bacteria.[9][10] Phenoxymethylpenicillin has a range of antimicrobial activity against Gram-positive bacteria that is similar to that of benzylpenicillin and a similar mode of action, but it is substantially less active than benzylpenicillin against Gram-negative bacteria.[9][10]. Phenoxymethylpenicillin is more acid-stable than benzylpenicillin, which allows it to be given orally.. Phenoxymethylpenicillin is usually used only for the treatment of mild to moderate infections, and not for severe or deep-seated infections since absorption can be unpredictable. Except for the treatment or prevention of infection with Streptococcus pyogenes (which is uniformly sensitive to penicillin), therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response.[11] People treated initially with parenteral ...

https://en.wikipedia.org/wiki/Phenoxymethylpenicillin

The in vitro activity of ceftolozane-tazobactam has been examined in five surveillance studies of isolates from Europe and North America.[8] In these studies, ceftolozane-tazobactam was notable for its activity against Pseudomonas aeruginosa, a moderately common cause of hospital-acquired infections that is commonly multi-drug resistant. Ninety percent of P. aeruginosa isolates were inhibited by a ceftolozane-tazobactam at a concentration of 4 μg/mL (MIC90), making it the most potent anti-pseudomonal antibiotic in clinical use. In these same studies, ceftolozane-tazobactam exhibited MIC90 values of ,1 μg/mL for Escherichia coli, Citrobacter koseri, Morganella morganii, Proteus mirabilis, Salmonella species, and Serratia marcescens. Somewhat poorer activity is observed for the Klebsiella and Enterobacter species, with the MIC90 for extended spectrum beta-lactamase (ESBL) expressing Klebsiella pneumonia being ,32 μg/mL. ...

https://en.wikipedia.org/wiki/Ceftolozane

"Vancomycin and ceftazidime incompatibility upon intravitreal injection". British Journal of Ophthalmology. 84 (1): 117-117. ...

https://en.wikipedia.org/wiki/Vancomycin_hydrochloride

InChI=1S/C16H21N7O7S3/c1-22-15(19-20-21-22)33-4-7-3-32-14-16(30-2,13(29)23(14)10(7)12(27)28)18-9(24)6-31-5-8(17)11(25)26/h8,14H,3-6,17H2,1-2H3,(H,18,24)(H,25,26)(H,27,28)/t8-,14-,16+/m1/s1 ‹See TfM› ...

https://en.wikipedia.org/wiki/Cefminox

... (SEF-di-nir) is a third-generation oral cephalosporin antibiotic sold under the brand names Cefzon and Omnicef. As of 2008, cefdinir, as Omnicef, was the highest-selling cephalosporin antibiotic in the United States, with more than US$585 million in retail sales of its generic versions alone.[1] Cefdinir is structurally similar to cefixime. It was discovered by Fujisawa Pharmaceutical Co., Ltd. (now Astellas) and introduced in 1991 under the brand name Cefzon.[2][3] Warner-Lambert licensed this cephalosporin for marketing in US from Fujisawa.[4] Abbott obtained U.S. marketing rights to Omnicef (cefdinir) in December 1998 through an agreement with Warner-Lambert Company.[5] It was approved by FDA on Dec 4, 1997.[6] It is available in US as Omnicef by Abbott Laboratories and in India as Cednir by Abbott, Kefnir by Glenmark, Cefdair by Xalra Pharma and Cefdiel by Ranbaxy. ...

https://en.wikipedia.org/wiki/Cefdinir

... comparing either ceftolozane alone or in combination with tazobactam to ceftazidime or meropenem) suggests that ceftolozane/ ... "Ceftolozane/tazobactam and ceftazidime/avibactam for the treatment of complicated intra-abdominal infections". Therapeutics ...

https://en.wikipedia.org/wiki/Ceftolozane/tazobactam

... is a second-generation cephalosporin antibiotic. It can be used to treat ear infections, skin infections, and other bacterial infections.[citation needed] It comes as a tablet and as a liquid suspension. Although there is a widely quoted cross-allergy risk of 10% between cephalosporins and penicillin, an article[1] has shown no increased risk for cross-allergy for cefprozil and several other second-generation or later cephalosporins. It was patented in 1983 and approved for medical use in 1992.[2] ...

https://en.wikipedia.org/wiki/Cefprozil

... has the ability to kill a wide variety of bacteria. Imipenem is the active antibiotic agent and works by interfering with their ability to form cell walls, so the bacteria break up and die. Imipenem is rapidly degraded by the renal enzyme dehydropeptidase if administered alone (making it less effective); the metabolites can cause kidney damage.[11] Imipenem is a broad-spectrum betalactam antibiotic used for severe bacterial infections caused by susceptible organisms. Because imipenem is rapidly inactivated by renal dehydropeptidase I, it is given in combination with cilastatin, a DHP-I inhibitor which increases half-life and tissue penetration of imipenem. Imipenem/cilastatin, like other carbapenems, binds to bacterial penicillin-binding proteins and interferes with bacterial cell wall integrity and synthesis. It has activity against many aerobic and anaerobic Gram-positive and Gram-negative organisms, including Staphylococcus aureus, Streptococcus pyogenes, S. agalactiae, S. ...

https://en.wikipedia.org/wiki/Imipenem/cilastatin

Lifshitz T, Lapid-Gortzak R, Finkelman Y, Klemperer I (January 2000). "Vancomycin and ceftazidime incompatibility upon ...

https://en.wikipedia.org/wiki/Vancomycin

cefepime, ceftazidime, imipenem, meropenem or piperacillin-tazobactam; plus ciprofloxacin, levofloxacin, amikacin, gentamicin, ... A third generation cephalosporin (ceftazidime) + carbapenems (imipenem) + beta lactam & beta lactamase inhibitors (piperacillin ...

https://en.wikipedia.org/wiki/Hospital-acquired_pneumonia

... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...

https://en.wikipedia.org/wiki/Schedule_H

It is usually susceptible to piperacillin, and ceftazidime. Tigecycline is also an effective drug. Polymyxin B may be effective ...

https://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia

Once the clinical condition improved, meropenem can be switched back to ceftazidime. Whether the ceftazidime or meropenem ... Intravenous ceftazidime is the current drug of choice for treatment of acute melioidosis and should be administered for at ... Resistance to ceftazidime, carbapenems, and co-amoxiclav are rare in the intensive phase, but are more prominent during ... In the same year, ceftazidime had been shown to reduce the risk of death of melioidosis from 74% to 37%. B. pseudomallei was ...

https://en.wikipedia.org/wiki/Melioidosis

Initial treatment typically includes antibiotics such as vancomycin, ceftriaxone or ceftazidime. Surgery in the form of joint ... ceftazidime +/- an aminoglycoside Once cultures are available, antibiotics can be changed to target the specific organism. ... or ceftazidime Gram stain negative and immunocompetent - vancomycin Gram stain negative and immunocompromised - vancomycin + ...

https://en.wikipedia.org/wiki/Septic_arthritis

1990). "Efficacy of ceftazidime in the treatment of acute pelvic infections". Niger Med. Pract. 20 (4): 77-78. Omigbodun, AO; ...

https://en.wikipedia.org/wiki/Akinyinka_Omigbodun

Studies has shown Anaerococcus prevotii presents resistance to Ceftazidime, Clindamycin, Levofloxacin. Unlike the other species ...

https://en.wikipedia.org/wiki/Anaerococcus

Ceftazidime, ofloxacin, trimethoprim and chloramphenicol have all been shown to induce filamentation. Treatment at or below the ...

https://en.wikipedia.org/wiki/Bacterial_morphological_plasticity

Despite their name, a few are more active on ceftazidime than cefotaxime. They have mainly been found in strains of Salmonella ... Ceftriaxone, cefotaxime, and ceftazidime have failed even more often, despite the organism's susceptibility to the antibiotic ... Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it ... These cephalosporins include cefotaxime, ceftriaxone, and ceftazidime, as well as the oxyimino-monobactam aztreonam. Thus ESBLs ...

https://en.wikipedia.org/wiki/Beta-lactamase

Treatment was ceftazidime and intravenous (IV) ciprofloxacin and IV doxycycline, which proved successful. Prevention of ... recommend treating the person with a quinolone or intravenous doxycycline with ceftazidime. The first successful documented ...

https://en.wikipedia.org/wiki/Vibrio_vulnificus

... ceftazidime, and metoclopramide. R.D. Adams and J.M. Foley first described asterixis in 1949 in patients with severe liver ...

https://en.wikipedia.org/wiki/Asterixis

"Taxonomic characterisation of ceftazidime-resistant Brevundimonas isolates and description of Brevundimonas faecalis sp. nov". ...

https://en.wikipedia.org/wiki/Brevundimonas_faecalis

... such as ceftazidime) tend to be more effective against gram-negative bacterial species that are resistant to the first- ... and third-generation ones (such as ceftazidime) tend to be more effective against gram-negative bacterial species that are ...

https://www.britannica.com/science/ceftazidime

Ceftazidime Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Take ceftazidime injection until you finish the prescription, even if you feel better. If you stop taking ceftazidime injection ... Before taking ceftazidime injection,. *tell your doctor and pharmacist if you are allergic to ceftazidime, other cephalosporin ... Ceftazidime injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: *pain, ...

https://medlineplus.gov/druginfo/meds/a686007.html

Ceftazidime is available as a generic medication. Ceftazidime is used to treat lower respiratory tract, skin, urinary tract, ... Ceftazidime/avibactam "Ceftazidime". The American Society of Health-System Pharmacists. Archived from the original on 20 ... Ceftazidime is contraindicated in people with a known allergy to ceftazidime or to any other cephalosporin antibiotic. ... Ceftazidime is mainly eliminated by the kidneys into the urine. As such, drug levels in the blood may build up in persons with ...

https://en.wikipedia.org/wiki/Ceftazidime

Ceftazidime and Avibactam Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before using ceftazidime and avibactam injection,. *tell your doctor and pharmacist if you are allergic to ceftazidime and ... It works by preventing bacteria from breaking down ceftazidime.. Antibiotics such as ceftazidime and avibactam will not work ... Your doctor will tell you how long to use ceftazidime and avibactam injection. You may receive ceftazidime and avibactam ...

https://medlineplus.gov/druginfo/meds/a615018.html

Ceftazidime-avibactam is now approved for the treatment of gram-negative bacterial infections in pediatric patients. Find out ... Ceftazidime-avibactam exhibits linear pharmacokinetics.[2] Less than 10% of the administered dose is bound to serum proteins. ... The pharmacokinetic profile of ceftazidime-avibactam was evaluated as part of a phase 1 safety and tolerability study conducted ... Cite this: Use of Ceftazidime-Avibactam in Infants and Children - Medscape - May 01, 2019. ...

https://www.medscape.com/viewarticle/914318_5

Ceftazidime-avibactam is now approved for the treatment of gram-negative bacterial infections in pediatric patients. Find out ... On March 18, 2019, the Food and Drug Administration (FDA) extended approval for ceftazidime-avibactam to pediatric patients 3 ... Ceftazidime-avibactam was first approved in 2015 for adults with cIAI and cUTI, and was subsequently approved for the treatment ...

https://www.medscape.com/viewarticle/914318

No se debe utilizar esta información para decidir si se debe tomar este medicamento o cualquier otro. Solamente el proveedor de atención médica tiene el conocimiento y la capacitación para decidir qué medicamentos son adecuados para un paciente específico. Esta información no recomienda ningún medicamento como seguro, eficaz o aprobado para tratar a ningún paciente o enfermedad. Es solamente un breve resumen de información general sobre este medicamento. NO incluye toda la información sobre los usos, las instrucciones, las advertencias, las precauciones, las interacciones, los efectos secundarios o los riegos posibles que podrían aplicarse a este medicamento. Esta información no constituye asesoramiento médico específico y no reemplaza la información que usted recibe de su proveedor de atención médica. Debe hablar con el proveedor de atención médica para obtener información completa sobre los riesgos y los beneficios de tomar este medicamento.. ...

https://www.mskcc.org/es/cancer-care/patient-education/ceftazidime-01

Professional guide for CefTAZidime. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse ... including ceftazidime. If a patient develops anemia while on ceftazidime, discontinue treatment until the etiology is ... IM: Ceftazidime can be administered deep IM into large mass muscle.. IV: Can be administered IV push over 3 to 5 minutes or by ... Ceftazidime has also been used successfully in cases of meningitis due to P. aeruginosa and S. pneumoniae. ...

https://www.drugs.com/ppa/ceftazidime.html

Detailed drug Information for ceftazidime Injection. Includes common brand names, drug descriptions, warnings, side effects and ... Proper Use of ceftazidime. A nurse or other trained health professional will give you ceftazidime. Ceftazidime is given as a ... Ceftazidime is available only with your doctors prescription.. Before Using ceftazidime. In deciding to use a medicine, the ... Uses For ceftazidime. Ceftazidime injection is used to treat bacterial infections in many different parts of the body. It ...

https://www.drugs.com/cons/ceftazidime-injection.html

Ceftazidime injection is used to treat many kinds of bacterial infections, including severe or life-threatening forms. ... Ceftazidime may also be used for purposes not listed in this medication guide. ... Ceftazidime is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body. ... What is ceftazidime injection?. Ceftazidime is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in ...

https://www.cigna.com/individuals-families/health-wellness/hw/medications/ceftazidime-injection-d00009a1

... is a combination medicine used in adults to treat complicated infections of the bladder, kidney, or ... Avibactam and ceftazidime may also be used for purposes not listed in this... ... Avibactam and ceftazidime are antibiotics that work by fighting bacteria in your body. ... How is avibactam and ceftazidime given?. Avibactam and ceftazidime is injected into a vein through an IV. You may be shown how ...

https://www.rexhealth.com/rh/health-library/document-viewer/?id=d08358a1

Halving of mortality of severe melioidosis by ceftazidime.. White NJ1, Dance DA, Chaowagul W, Wattanagoon Y, Wuthiekanun V, ... Ceftazidime treatment was associated with a 50% (95% CI 19-81%) lower overall mortality than conventional treatment (74% vs 37 ... An open randomised trial was conducted to compare ceftazidime (120 mg/kg/day) with "conventional therapy" (chloramphenicol 100 ...

https://www.ncbi.nlm.nih.gov/pubmed/2570956?dopt=Abstract

Summary of the evidence on ceftazidime/avibactam for complicated intra-abdominal and UTI infections and hospital-acquired ... This evidence summary outlines the best available evidence for a new intravenous antimicrobial, ceftazidime/avibactam ( ...

https://www.nice.org.uk/advice/es16

Ceftazidime) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications ... Ceftazidime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Ceftazidime has activity in the ... Ceftazidime is generally well tolerated. The incidence of adverse reactions associated with the administration of ceftazidime ... FORTAZ is available as a frozen, iso-osmotic, sterile, nonpyrogenic solution with 1 or 2 g of ceftazidime as ceftazidime sodium ...

https://www.rxlist.com/fortaz-drug.htm

Summary of the evidence on ceftazidime/avibactam for complicated intra-abdominal and UTI infections and hospital-acquired ...

https://www.nice.org.uk/advice/ES16/resources

Ceftazidime/Fortaz/Tazidine. Ceftazidime/Fortaz/Tazidine. - See: Third Generation Cephalosporin. - Adults: 25 to 150 mg/kg/day ... ceftazidime has little activity against most anaerobes. Ceftazidime in treatment of urinary tract infection in patients with ... Ceftazidime:. - is not as active as the other third-generation cephalosporins against gram-positive cocci, although it is ...

https://www.wheelessonline.com/muscles-tendons/ceftazidime-fortaz-tazidine/

Find user ratings and reviews for ceftazidime injection on WebMD including side effects and drug interactions, medication ... Read user comments about the side effects, benefits, and effectiveness of ceftazidime injection. ...

https://www.webmd.com/drugs/drugreview-1769-ceftazidime-vial.aspx?drugid=1769&

Ceftazidime vs. amoxicillin/clavulanate in the treatment of severe melioidosis.. Suputtamongkol Y1, Rajchanuwong A, Chaowagul W ... However, 4 of 75 surviving patients in the ceftazidime group compared with 16 of 69 surviving patients in the amoxicillin/ ... An open, paired, randomized, controlled trial of high-dose parenteral ceftazidime (120 mg/[kg.d]) vs. amoxicillin/clavulanate ( ... Parenteral amoxicillin/clavulanate is a safe and effective initial treatment, but parenteral ceftazidime remains the treatment ...

https://www.ncbi.nlm.nih.gov/pubmed?cmd=Retrieve&db=PubMed&list_uids=7893868&dopt=Abstract

The appearance of Ceftazidime can differ based on the dosing. ... CEFTAZIDIME (injection, powder, for solution) comes in ...

https://www.healthgrades.com/drugs/ceftazidime/dosage

Find the most comprehensive real-world treatment information on Ceftazidime-Avibactam at PatientsLikeMe. 0 patients with ... bipolar I disorder or psoriasis currently take Ceftazidime-Avibactam. ... The combination of ceftazidime, a cephalosporin, and avibactam, a beta-lactamase inhibitor, may be used for the treatment of ...

https://www.patientslikeme.com/treatments/show/27947-ceftazidimeavibactam-side-effects-and-efficacy

Ceftazidime-avibactam for Injection) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, ... AVYCAZ 2.5 grams (ceftazidime and avibactam) for injection is supplied in single-dose, clear glass vial containing: ceftazidime ... Ceftazidime and avibactam were each evaluated for mutagenic potential in several in vitro and in vivo assays. Ceftazidime was ... Ceftazidime. Ceftazidime is a semisynthetic, beta-lactam antibacterial drug. It is the pentahydrate of (6R,7R,Z)-7-(2-( ...

https://www.rxlist.com/avycaz-drug.htm

MICs were determined for ceftazidime-avibactam (ceftazidime: USP, avibactam: Forest Laboratories, Inc.), meropenem (USP), and ... The ceftazidime-avibactam MIC for one E. coli isolate was increased by 4-fold when incubated in 5% CO2 (Table 1). Incubation in ... Three isolates had ceftazidime-avibactam MICs that were increased by 4- to 8-fold when the inoculum was increased 10-fold (5 × ... R. K. Flamm, G. G. Stone, H. S. Sader, R. N. Jones, and W. W. Nichols, "Avibactam reverts the ceftazidime MIC90 of European ...

https://www.hindawi.com/journals/isrn/2015/489547/

Ceftazidime Login required for. Ceftazidime Please note that due to the Association of the British Pharmaceutical Industry body ...

https://www.fresenius-kabi.com/gb/products/ceftazidime-kabi

Ceftazidime injection is used to treat many kinds of bacterial infections, including severe or life-threatening forms. ... Ceftazidime may also be used for purposes not listed in this... ... Ceftazidime is in a group of drugs called cephalosporin (SEF a ... How is ceftazidime injection given?. Ceftazidime is injected into a vein through an IV. You may be shown how to use an IV at ... What is ceftazidime injection?. Ceftazidime is in a group of drugs called cephalosporin (SEF a low spor in) antibiotics. It ...

https://www.peacehealth.org/medical-topics/content/multum/d00009a1.html

On this page about Ceftazidime (Aspen) you will find information relating to side effects, age restrictions, food interactions ... Brand name: Ceftazidime (Aspen) TM. Active ingredients: ceftazidime On February 26, 2020 Ceftazidime (Aspen) was not listed on ... Other medicines containing the same active ingredients: ceftazidime *Can I take Ceftazidime (Aspen) in sport? Find out on the ...

https://www.healthdirect.gov.au/medicines/brand/amt,924377011000036100/ceftazidime-aspen

Ceftazidime. Classification: A Drug products: Ceftazidim Actavis, Ceftazidim Dr. Eberth, Ceftazidim Sandoz, Ceftazidime, Fortam ... The pharmacokinetics of ceftazidime was assessed in healthy volunteers (12 men, 12 women) receiving 1 g ceftazidime as bolus i. ... In patients with community-acquired pneumonia, the response to ceftazidime was similar in men and women.. In our opinion, the ... Eight men and eight women also received 1 g ceftazidime i.m. injection. Compared to men, women had 38% higher volume of ...

https://janusinfo.se/beslutsstod/janusmedkonochgenus/janusmedsexandgender/database/ceftazidime.4.492f438316ec5fbe712ffdc.html

On this page about Ceftazidime (SXP) you will find information relating to side effects, age restrictions, food interactions, ... Other medicines containing the same active ingredients: ceftazidime *Can I take Ceftazidime (SXP) in sport? Find out on the ... For the active ingredient ceftazidime. You should seek advice from your doctor or pharmacist about taking this medicine. They ... For the active ingredient ceftazidime. You should seek advice from your doctor or pharmacist about taking this medicine. They ...

https://www.healthdirect.gov.au/medicines/brand/amt,927789011000036108/ceftazidime-sxp

Experimental: 1: nebulized ceftazidime and amikacin Drug: ceftazidime and amikacin Nebulized ceftazidime 15 mg/kg/3h during 8 ... Active Comparator: 2: intravenous ceftazidime and amikacin Drug: ceftazidime and amikacin Intravenous infusion of ceftazidime ... Nebulized Ceftazidime and Amikacin in Ventilator Associated Pneumonia. The safety and scientific validity of this study is the ... The aim of the study is to assess the efficiency of nebulized ceftazidime and amikacin in the treatment of pneumonia caused by ...

https://clinicaltrials.gov/ct2/show/NCT00786305

Our website uses cookies to enhance the user experience and provide the best possible service. By continuing to browse the website, you consent to our use of cookies. Click here to view the Privacy Policy.. ...

https://www.fresenius-kabi.com/nz/products/Ceftazidime_Kabi

Ceftazidime indications and usages ATC and ICD codes, combinations with other active ingredients and trade names information ... Ceftazidime - Dexa Medica Pharm & Chem. Ceftazidime - Makiz-Pharma. Ceftazidime - Medopharm. Ceftazidime - Merck. Ceftazidime ... Ceftazidime - Pascual Laboratories. Ceftazidime - RiteMED Phils. Ceftazidime - Sanofi-Aventis. Ceftazidime - Teva. Ceftazidime ... Ceftazidime - Actavis. Ceftazidime - Aguettant. Ceftazidime - Arrow Generiques. Ceftazidime - Aurobindo. Ceftazidime - Biogaran ...

https://drugs-about.com/ing/ceftazidime.html

Ceftazidime, sold under the brand names Fortaz among others, is an antibiotic useful for the treatment of a number of bacterial infections. (wikipedia.org)
FORTAZ is a sterile, dry-powdered mixture of ceftazidime pentahydrate and sodium carbonate. (rxlist.com)
FORTAZ in sterile crystalline form is supplied in single-dose vials equivalent to 500 mg, 1 g, or 2 g of anhydrous ceftazidime and in TwistVial™ single-dose vials equivalent to 1 or 2 g of anhydrous ceftazidime. (rxlist.com)
FORTAZ is available as a frozen, iso-osmotic, sterile, nonpyrogenic solution with 1 or 2 g of ceftazidime as ceftazidime sodium premixed with approximately 2.2 or 1.6 g, respectively, of Dextrose Hydrous, USP. (rxlist.com)
Can pregnant women take Fortaz (ceftazidime)? (healthtap.com)

Sodium hydroxide is used to adjust pH and neutralize ceftazidime pentahydrate free acid to the sodium salt. (rxlist.com)
AVYCAZ is an antibacterial combination product consisting of the semisynthetic cephalosporin ceftazidime pentahydrate and the beta-lactamase inhibitor avibactam sodium for intravenous administration. (rxlist.com)
AVYCAZ 2.5 grams (ceftazidime and avibactam) for injection is a white to yellow sterile powder for constitution consisting of ceftazidime pentahydrate and avibactam sodium packaged in glass vials. (rxlist.com)
Each AVYCAZ 2.5 grams single-dose vial contains ceftazidime 2 grams (equivalent to 2.635 grams sterile ceftazidime pentahydrate/sodium carbonate) and avibactam 0.5 grams (equivalent to 0.551 grams sterile avibactam sodium). (rxlist.com)
Ceftazidime pentahydrate is an antibacterial agent. (alfa.com)
Ceptaz / ceftazidime (ceftazidime pentahydrate and L-arginine ) is an antibiotic which is given IV or IM. (healthtap.com)
Ceftazidime pentahydrate is a third-generation cephalosporin antibiotic and is sparingly soluble in aqueous solution (0.396 mg/mL). (toku-e.com)
Ceftazidime pentahydrate targets primarily gram negative bacteria especially Pseudomonas aeruginosa unlike other third generation cephalosporins. (toku-e.com)
Ceftazidime pentahydrate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. (toku-e.com)

Ceftazidime is contraindicated in people with a known allergy to ceftazidime or to any other cephalosporin antibiotic. (wikipedia.org)
Ceftazidime is a cephalosporin (SEF a low spor in) antibiotic. (cigna.com)
Chahine EB, Sourial M, Ortiz R. Ceftazidime/Avibactam: A New Antibiotic for Gram-Negative Infections. (unboundmedicine.com)
CEFTAZIDIME (SEF tay zi deem) is a cephalosporin antibiotic. (ahealthyme.com)
Ceftazidime is a beta-Lactam antibiotic used for the treatment of a number of bacterial infections. (sciencephoto.com)
Ceftazidime(Ceptaz) generic Belzid® [Vial] is a cephalosporin antibiotic, prescribed for certain types of bacterial infections. (medindia.net)
Ceftazidime is a cephalosporin antibiotic . (healthtap.com)
The therapeutic efficacy of gentamicin and ceftazidime coencapsulated into liposomes was examined by monitoring survival in a rat model of an acute unilateral pneumonia caused by antibiotic-susceptible and antibiotic-resistant Klebsiella pneumoniae strains. (aspetjournals.org)
Ceftazidime is a third generation cephalosporin which is a kind of cephalosporin type drug (anti-bacterial drug, antibiotic and antimicrobial). (healthtap.com)
CAZ-AVI combines a broad-spectrum cephalosporin (ceftazidime) and a novel beta-lactamase inhibitor (avibactam, formerly NXL104) to overcome antibiotic-resistance and treat the increasing number of infections resistant to existing therapies. (astrazeneca.com)
In December 2009, AstraZeneca entered into an agreement to acquire Novexel, a private infection research company in France while simultaneously announcing an agreement to collaborate with Forest Laboratories on the future co-development and commercialisation of two late-stage antibiotic development programmes: ceftazidime/avibactam and ceftaroline fosamil/avibactam. (astrazeneca.com)
As ceftazidime/avibactam was still not approved by the Spanish Medicines Agency, this antibiotic was obtained on a compassionate basis. (deepdyve.com)
Ceftazidime is the antibiotic of choice for treatment of Burkholderia pseudomallei infections (melioidosis). (tropmedres.ac)
Ceftazidime seems to be an effective and safe antibiotic in the treatment of Ps. (mysciencework.com)

Ceftazidime is also commonly prescribed off-label for nebulization in people with cystic fibrosis for the suppression of Pseudomonas aeruginosa in the lungs as well as the treatment of pulmonary exacerbations. (wikipedia.org)
Ceftazidime is one of the few in this class with activity against Pseudomonas aeruginosa. (wikipedia.org)
The following represents MIC susceptibility data for a few clinically significant pathogens: Escherichia coli - 0.015 μg/mL - 512 μg/mL Pseudomonas aeruginosa - ≤0.03 μg/mL - 1024 μg/mL Ceftazidime is generally well tolerated. (wikipedia.org)
Effects of varying in vitro susceptibility testing parameters of the broth microdilution assay on ceftazidime-avibactam MICs were determined and compared to meropenem and piperacillin-tazobactam for 9 Enterobacteriaceae and 4 Pseudomonas aeruginosa isolates. (hindawi.com)
The effect of varying the broth microdilution in vitro testing parameters on the ceftazidime-avibactam MIC of β -lactamase positive and negative Enterobacteriaceae and Pseudomonas aeruginosa isolates was determined and compared with the effects on meropenem and piperacillin-tazobactam MICs. (hindawi.com)
The aim of the study is to assess the efficiency of nebulized ceftazidime and amikacin in the treatment of pneumonia caused by Pseudomonas aeruginosa in ventilated patients. (clinicaltrials.gov)
Is ceftazidime for the treatment of the "pseudomonas infection" in the ear? (healthtap.com)
Pseudomonas is a common cause of swimmer's ear or otitis externa and is usally treated topically, however, in diabetics and some immunocompromised people, the organism invades into the temporal bone of the skull and then is treated with systemic antimicrobials such as ceftazidime. (healthtap.com)
Are dalacin & ceftazidime the right treatment of the "pseudomonas infection" in the ear? (healthtap.com)
AIM To predict the ceftazidime dosage regimen as a function of the glomerular filtration rate expressed by the modification of the diet in renal disease (MDRD), reason for admission and mechanical ventilation in intensive care unit (ICU) patients to treat Pseudomonas aeruginosa pneumonia. (nih.gov)
Fifty-six cases of acute pulmonary exacerbation of the disease in 42 patients associated with isolation of Pseudomonas aeruginosa from the sputum were randomly treated with either aztreonam or ceftazidime (300mg/kg/day i.v. (nih.gov)
Moxifloxacin displayed the largest mean ZOI against S. epidermidis (43 mm) and S. aureus (40 mm), while ceftazidime showed the largest mean ZOI against Pseudomonas (38 mm). (arvojournals.org)
I am receiving Ceftazidime 2x daily for 7 days by midline IV for a chronic Pseudomonas aeruginosa infection of my kidney stones. (medschat.com)
Ceftazidime is usually reserved for the treatment of infections caused by Pseudomonas aeruginosa. (medschat.com)
In this study, our aim was to investigate the relationship between CLASS-1 integrons and PER-1 enzyme in ceftazidime-resistance Pseudomonas aeruginosa . (alliedacademies.org)
The PER-1 type beta lactamase enzyme that causes ceftazidime-resistance, determines the frequency, and detects the relationship between the enzyme and CLASS-1 integrons by PCR in 100 (one hundred) ceftazidime-resistant Pseudomonas aeruginosa ( P. aeruginosa ) isolated at Ondokuz May?s University Hospital (Turkey) between 2007 and 2008. (alliedacademies.org)
Ceftazidime treatment of chronic Pseudomonas aeruginosa respir. (mysciencework.com)
Ceftazidime treatment of chronic Pseudomonas aeruginosa respiratory tract infection in cystic fibrosis. (mysciencework.com)
Two open randomized cross-over studies were undertaken comparing ceftazidime to tobramycin and ceftazidime to tobramycin plus carbenicillin in 13 and 15 cystic fibrosis (CF) patients, respectively, with chronic bronchopulmonary Pseudomonas aeruginosa infection. (mysciencework.com)

The recommended dosage of AVYCAZ is 2.5 grams (ceftazidime 2 grams and avibactam 0.5 grams) administered every 8 hours by intravenous (IV) infusion over 2 hours in patients 18 years of age and older in patients with normal renal function. (rxlist.com)
The U.S. Food and Drug Administration (FDA) is warning health care professionals about the risk for dosing errors with the intravenous antibacterial drug Avycaz (ceftazidime and avibactam) due to confusion about the drug strength displayed on the vial and carton labels. (fda.gov)
To prevent medication errors, we have revised the labels to indicate that each vial contains Avycaz 2.5 gram, equivalent to ceftazidime 2 gram and avibactam 0.5 gram (see Photos). (fda.gov)
Avycaz is a combination product consisting of ceftazidime, a cephalosporin antibacterial drug, and avibactam, an inhibitor of certain beta-lactamase enzymes. (fda.gov)
Each vial contains 2.5 gram of Avycaz (ceftazidime 2 gram and avibactam 0.5 gram). (fda.gov)
The pharmacies prepared the Avycaz dose based on the ceftazidime portion alone rather than the intended 1 gram of ceftazidime and 250 mg of avibactam. (fda.gov)
A total of 870 hospitalized adult patients with HABP or VABP were randomized and received trial medications in a pivotal Phase 3, multinational, double-blind trial (REPROVE) comparing AVYCAZ 2.5 g (ceftazidime 2 grams and avibactam 0.5 grams) intravenously every 8 hours to meropenem 1 gram intravenously every 8 hours, for 7 to 14 days of therapy. (allergan.com)
DUBLIN, March 18, 2019 -- (Healthcare Sales & Marketing Network) -- Allergan plc (NYSE: AGN) today announced that the U.S. Food and Drug Administration (FDA) has approved the company's supplemental New Drug Application (sNDA) for AVYCAZ (ceftazidime and avibactam), expanding the label to include pediatric patients 3 months and older for the treatment of complicated intra-abdominal infections (cIAI) in combination with metronidazole and complicated urinary tract infection s (cUTI). (salesandmarketingnetwork.com)
AVYCAZ consists of a combination of avibactam and ceftazidime. (salesandmarketingnetwork.com)

What are the possible side effects of ceftazidime injection? (cigna.com)

Antibiotics such as ceftazidime injection will not work for colds, flu, or other viral infections. (medlineplus.gov)
Ceftazidime injection is also sometimes used to treat patients who have a fever and are at high risk for infection because they have a low number of white blood cells, melioidosis (a serious infection that is common in places with a tropical climate), certain wound infections, and food poisoning. (medlineplus.gov)
The combination of ceftazidime and avibactam injection is used with metronidazole (Flagyl) to treat abdominal (stomach area) infections. (medlineplus.gov)
On March 18, 2019, the Food and Drug Administration (FDA) extended approval for ceftazidime-avibactam to pediatric patients 3 months of age and older for the treatment of complicated intra-abdominal infections (cIAI) in combination with metronidazole and the treatment of complicated urinary tract infections (cUTI) including pyelonephritis. (medscape.com)
Ceftazidime injection is used to treat bacterial infections in many different parts of the body. (drugs.com)
Ceftazidime injection is used to treat many kinds of bacterial infections, including severe or life-threatening forms. (cigna.com)
Avibactam and ceftazidime is a combination medicine used in adults to treat complicated infections of the bladder, kidney, or stomach and intestines. (rexhealth.com)
The combination of ceftazidime, a cephalosporin, and avibactam, a beta-lactamase inhibitor, may be used for the treatment of patients with complicated intra-abdominal infections or urinary tract infections. (patientslikeme.com)
Since isolates with OXA-48 frequently harbor extended-spectrum β-lactamases that are inhibited by avibactam, it is likely that ceftazidime-avibactam will be used to treat infections caused by OXA-48-producing Enterobacterales. (unboundmedicine.com)
The increasing rate of methicillin-resistant Staphylococcus aureus (MRSA) infections is also a concern.1 One newer intravenous cephalosporin (ceftaroline) was approved in 2010, and 2 new intravenous cephalosporin-β-lactamase inhibitor combinations (ceftolazone-tazobactam and ceftazidime-avibactam) have recently been approved to try to combat these resistant organisms in adult patients. (aacn.org)
Forest announced that the FDA has designated its investigational drug, ceftazidime/avibactam, a Qualified Infectious Disease Product (QDIP) for complicated intra-abdominal infections (cIAI), complicated urinary tract infections (cUTI) and hospital-acquired bacterial pneumonia/ventilator-associated bacterial pneumonia (HABP/VABP). (empr.com)
Ceftazidime/avibactam is a combination broad-spectrum cephalosporin (ceftazidime) and a novel beta-lactamase inhibitor (avibactam, formerly NXL104) to treat Gram-negative infections, including extended-spectrum beta-lactamases and Klebsiella pneumoniae carbapenemases that are resistant to existing therapies. (empr.com)
Ceftazidime/avibactam is currently in Phase 3 trials to investigate the efficacy in treating hospitalized patients with complicated intra-abdominal infections (cIAI) and complicated urinary tract infections (cUTI), both of which are serious Gram-negative bacterial infections . (empr.com)
Ceftazidime is indicated for the treatment of the infections listed below in adults and children including neonates (from birth). (medicines.org.uk)
Ceftazidime may be used in the peri-operative prophylaxis of urinary tract infections for patients undergoing trans-urethral resection of the prostate (TURP). (medicines.org.uk)
Ceftazidime treats several different types of bacterial infections. (rxwiki.com)
AstraZeneca and Forest Laboratories, Inc. announced today that ceftazidime/avibactam (CAZ-AVI) will enter phase III trials to investigate efficacy in treating hospitalised patients with serious Gram-negative bacterial infections including Complicated Intra-Abdominal Infections (cIAI) and Complicated Urinary Tract Infections (cUTI). (astrazeneca.com)

This evidence summary outlines the best available evidence for a new intravenous antimicrobial, ceftazidime/avibactam (Zavicefta). (nice.org.uk)
Within 10 days, her haemoglobin recovered to 100 g/L. Author comment: '[W]e present a case of DIIHA secondary to intravenous (IV) ceftazidime use in a person with CF.' Yong J, et al. (deepdyve.com)

The combination of ceftazidime and avibactam injection comes as a powder to be added to fluid and injected intravenously (into a vein). (medlineplus.gov)
Based upon knowledge of the hydrolytic profile of major β-lactamases found in Gram negative bacteria, we tested the effectiveness of the combination of ceftazidime/avibactam (CAZ/AVI) with aztreonam (ATM) against carbapenem-resistant enteric bacteria possessing metallo-β-lactamases (MBLs). (duke.edu)

Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae . (asm.org)
We examined the ability of NXL104 ( 1 , 22 ), a novel-structure inhibitor, to protect against carbapenemases when tested with ceftazidime (this combination is currently in phase II trials) and aztreonam, which has the advantage over ceftazidime of stability to metallo-β-lactamases. (asm.org)
In order to determine the optimal antipseudomonal therapy in patients with cystic fibrosis aztreonam plus amikacin was compared to ceftazidime plus amikacin, and these two-week hospital regimens were followed by oral ciprofloxacin given for four weeks. (nih.gov)
In patients with cystic fibrosis, aztreonam or ceftazidime in combination with amikacin represents an effective and safe systemic anti-pseudomonal therapy. (nih.gov)
Can ceftazidime/avibactam and aztreonam overcome β-lactam resistance conferred by metallo-β-lactamases in Enterobacteriaceae? (duke.edu)
Clinical outcomes after combination treatment with ceftazidime/avibactam and aztreonam for. (deepdyve.com)
In our hospital, we experienced an outbreak of Klebsiella pneumoniae ST147 in late 2015 caused by an XDR strain producing NDM-1 + OXA-48 + CTX-M-15 (KP-HUB-ST147).6 Herein, we retrospectively review the outcomes of 10 patients treated with ceftazidime/avibactam plus aztreonam between January 2016 and June 2017 at Bellvitge University Hospital, Barcelona, Spain. (deepdyve.com)

Tell your doctor if you have ever had any unusual or allergic reaction to ceftazidime or any other medicines. (drugs.com)

If you stop taking ceftazidime injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
It works by preventing bacteria from breaking down ceftazidime. (medlineplus.gov)
Avibactam and ceftazidime are antibiotics that work by fighting bacteria in your body. (rexhealth.com)
The selection of ceftazidime should take into account its antibacterial spectrum, which is mainly restricted to aerobic Gram negative bacteria (see sections 4.4 and 5.1). (medicines.org.uk)
Ceftazidime should be co-administered with other antibacterial agents whenever the possible range of causative bacteria would not fall within its spectrum of activity. (medicines.org.uk)
Ceftazidime belongs to a group of drugs called cephalosporin antibiotics, which work to stop the growth of bacteria in the body. (rxwiki.com)

MICs were determined for ceftazidime-avibactam (ceftazidime: USP, avibactam: Forest Laboratories, Inc.), meropenem (USP), and piperacillin-tazobactam (piperacillin: Sigma, tazobactam: USP) by broth microdilution assay according to CLSI guidelines [ 8 , 9 ]. (hindawi.com)

You may receive ceftazidime injection in a hospital or you may administer the medication at home. (medlineplus.gov)
If you will be receiving ceftazidime injection at home, your healthcare provider will show you how to use the medication. (medlineplus.gov)
Ceftazidime is available as a generic medication. (wikipedia.org)
Ceftazidime may also be used for purposes not listed in this medication guide. (cigna.com)

Isolates showed higher levels of resistance to ceftazidime (MIC 128 mg/L) than to ceftriaxone (MIC 8 mg/L). (cdc.gov)
To understand the development of resistance and evolutionary trajectories under CAZ-AVI exposure, we studied the effects of ceftazidime (CAZ) and CAZ-AVI on the carbapenemase OXA-48 and the epidemic OXA-48 plasmid in Escherichia coli Exposure of CAZ and CAZ-AVI resulted in single (P68A) and double (P68A,Y211S) amino acid substitutions in OXA-48, respectively. (unboundmedicine.com)
Thus, resistance toward ceftazidime-avibactam among OXA-48-producing Enterobacterales should be monitored. (unboundmedicine.com)
Interestingly, the compromising effect of the amino acid substitutions in OXA-48 on other β-lactams and the effect of ceftazidime-avibactam exposure on the epidemic OXA-48 plasmid indicate that the evolution of ceftazidime-avibactam resistance comes with collateral effects. (unboundmedicine.com)
Those KPC variants confer acquired resistance to CZA on the corresponding producers mainly as a consequence of decreased inhibitory activity of AVI against those enzymes, but also due to higher hydrolytic efficiency toward ceftazidime (CAZ). (asm.org)
1 Antimicrobial resistance surveillance serves as a fundamental basis for appreciating trends in resistance, developing accurate treatment guidelines, and evaluating the efficacy of interventions ( www.who.int/drugresistance/en/ ). (pubmedcentralcanada.ca)
PER-1 enzyme is derived from an extended spectrum beta-lactamase that is non-TEM, non-SHV-derived in class A and especially causes ceftazidime resistance. (alliedacademies.org)
Burkholderia pseudomallei acquired ceftazidime resistance due to gene duplication and amplification. (tropmedres.ac)
The wild-type penA gene confers clinically significant ceftazidime resistance only when overexpressed due to a promoter mutation, transcriptional anti-termination or by gene duplication and amplification (GDA). (tropmedres.ac)
GDA involving β-lactamase may be a common ceftazidime resistance mechanism in B. pseudomallei. (tropmedres.ac)
Development of resistance against both ceftazidime and carbenicillin was seen regularly and was not prevented by combination therapy with tobramycin. (mysciencework.com)
Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases, however, ceftazidime is stable in the presence of β-lactamases. (toku-e.com)

If you become pregnant while taking ceftazidime injection, call your doctor. (medlineplus.gov)

This is not a complete list of ceftazidime side effects. (rxwiki.com)
This is not a complete list of ceftazidime drug interactions. (rxwiki.com)

and third-generation ones (such as ceftazidime ) tend to be more effective against gram-negative bacterial species that are resistant to the first-generation cephalosporins. (britannica.com)

Mean maximum plasma ceftazidime concentrations (C max ) for the four cohorts were 79.8 mg/L (CV% 41.8), 81.3 mg/L (17.8), 80.1 mg/L (14.7), and 91.7 mg/L (19.6), respectively. (medscape.com)
The values for ceftazidime concentrations in milk over time at 1 h and 12 h post-administration of the 1st dose of antibiotics in healthy and mastitic cows were high (1028.2 ± 723.1 and 30.5 ± 25.7 and 966.8 ± 278.0 and 131.3 ± 34.9 µg/ml, respectively). (scielo.org.za)
Joanna Kwiecińska-Piróg, Krzysztof Skowron, Katarzyna Zniszczol, and Eugenia Gospodarek, "The Assessment of Proteus mirabilis Susceptibility to Ceftazidime and Ciprofloxacin and the Impact of These Antibiotics at Subinhibitory Concentrations on Proteus mirabilis Biofilms," BioMed Research International , vol. 2013, Article ID 930876, 8 pages, 2013. (hindawi.com)
A published and qualified population pharmacokinetic model was used to perform Monte Carlo simulations of ceftazidime concentrations. (nih.gov)
High-performance liquid chromatography was used to determine serum ceftazidime concentrations. (eur.nl)
The latter concentrations were all still substantially higher than the MIC of ceftazidime for major neonatal pathogens. (eur.nl)

Ceftazidime injection comes as a powder to be mixed with liquid and given intravenously (into a vein) or intramuscularly (into a muscle). (medlineplus.gov)
Avibactam and ceftazidime is a powder medicine that must be mixed with a liquid (diluent) in an IV bag before using it. (rexhealth.com)

Human serum and human serum albumin were previously shown to have no effect on ceftazidime-avibactam MICs [ 10 ]. (hindawi.com)
Serum concentration of iv ceftazidime in NLTG and LTG goats is best described by 2 and 3 compartment models, respectively. (scielo.org.za)
In conclusion, ceftazidime, when administered to goats, showed high concentration times in serum, good penetration into milk and a bioavailability that makes it suitable to be used by the im route. (scielo.org.za)
1 In neonates and infants ≤ 2 months, the serum half life of ceftazidime can be three to four times that in adults. (medicines.org.uk)
The half-life for the elimination of the drug from serum, apparent volume of distribution, total body clearance of ceftazidime, and inulin clearance were not significantly different for both groups. (eur.nl)
The aim of our present work was to predict in burn patients the best adapted ceftazidime dosage regimen to obtain a serum target of 40 to 100 mg/l taking into account the influence of patients' characteristics on ceftazidime pharmacokinetics (PK). (biomedcentral.com)
Serum creatinine and age were identified as covariates of ceftazidime clearance. (biomedcentral.com)
Recommended ceftazidime dosage regimen after a 2 g loading dose required to reach a steady-state concentration between 40 and 100 mg/l in the highest percentage of typical burn patients in function of serum creatinine and age. (biomedcentral.com)
Age and serum creatinine significantly influence the ceftazidime disposition. (biomedcentral.com)
Serum concentration curves for ceftazidime fitted a two compartment first order open model in CF patients and showed a distribution volume of 40% of the body weight and a final serum half-life of 1.8 h. (mysciencework.com)

Methods: Using an in vitro pharmacokinetic model we simulated human drug concentration-time courses associated with ceftaroline 600 mg every 8 h and ceftazidime 2000 mg every 8 h. (ovid.com)

Isolates were resistant to penicillins and ceftazidime but were susceptible to other antimicrobial drug classes tested. (cdc.gov)
including carbapenem-nonsusceptible strains, while ceftazidime/avibactam effectively inhibits a broad range of β-lactamases, making it an excellent option for the treatment of carbapenem-resistant Enterobacteriaceae. (dovepress.com)
Among the recently developed agents active against multidrug-resistant Gram-negative pathogens, a novel drug combination has been launched, namely, ceftazidime-avibactam (CZA) ( 2 ). (asm.org)
Ceftazidime/avibactam has been successfully used to treat infection caused by carbapenem-resistant Enterobacteriaceae;2,3 however, the combination lacks activity against strains producing NDM. (deepdyve.com)
Increase of Ceftazidime- and Fluoroquinolone-Resistant Klebsiella pneumoniae and Imipenem-Resistant Acinetobacter spp. (pubmedcentralcanada.ca)
Here we characterize a reversible 33-kb GDA event involving wild-type penA in a ceftazidime resistant clinical isolate from Thailand. (tropmedres.ac)

The overall therapeutic failure rate (i.e., treatment failure or death due to uncontrolled melioidosis) was significantly higher for the amoxicillin/clavulanate group than for the ceftazidime group (P = .02). (nih.gov)
On February 26, 2020 Ceftazidime (Aspen) was not listed on the Australian Register of Therapeutic Goods (ARTG). (healthdirect.gov.au)

Ceftazidime falls under the pregnancy category B. According to the manufacturer, research studies in mice and rats showed no evidence of harm to the fetus, even at up to 40 times the human dose of ceftazidime. (wikipedia.org)
Some may experience nervous symptom abnormalities such as a seizure or disturbances of consciousness (confusion, hallucinations, stupor, coma) when the dose of ceftazidime exceeds the recommended dose, especially in the presence of kidney dysfunction. (rxwiki.com)

The authors suggest that the dosage of ceftazidime should be increased in pregnancy by approximately 40% [5]. (janusinfo.se)
The usual recommended dosage of ceftazidime is not adapted for all ICU situations and ceftazidime should be monitored closely. (nih.gov)

No studies with a clinically relevant sex analysis regarding adverse effects of ceftazidime have been found. (janusinfo.se)
Madeline King, PharmD, assistant professor of Clinical Pharmacy at the University of the Sciences, Philadelphia College of Pharmacy in Philadelphia, Pennsylvania, explains how her future research aims to understand the effects of ceftazidime-avibactam in different patient populations. (contagionlive.com)

Also tell your doctor if you are allergic to any of the ingredients in ceftazidime injection. (medlineplus.gov)
any other medications, or any of the ingredients in ceftazidime and avibactam injection. (medlineplus.gov)

The pharmacokinetics of ceftazidime was assessed in healthy volunteers (12 men, 12 women) receiving 1 g ceftazidime as bolus i.v. injection. (janusinfo.se)
The pharmacokinetics of ceftazidime were best described by using a one-compartment model. (eur.nl)

Ceftazidime is the first-line treatment for the tropical infection, melioidosis, an important cause of sepsis in Asia and Australia. (wikipedia.org)
If you still have symptoms of infection after you finish ceftazidime and avibactam injection, tell your doctor. (medlineplus.gov)
Ceftazidime will not treat a viral infection such as the flu or a common cold. (cigna.com)
Ceftazidime may be used in the management of neutropenic patients with fever that is suspected to be due to a bacterial infection. (medicines.org.uk)

In medium with acidic pH (pH 5 or 6), MICs for ceftazidime-avibactam were increased by 4- to 16-fold for 6 of 9 Enterobacteriaceae isolates and were decreased by 4-fold for 2 of 4 P. aeruginosa isolates (Table 1 ). (hindawi.com)

Naperville, IL -- ( SBWIRE ) -- 05/21/2015 -- Reportstack, provider of premium market research reports announces the addition of Global Ceftazidime with Sodium carbonate sterile Industry 2015 Market Research Report market report to its offering. (sbwire.com)
2015 Global Ceftazidime with Sodium carbonate sterile Industry Report is a professional and in-depth research report on the world's major regional market conditions of the Ceftazidime with Sodium carbonate sterile industry, focusing on the main regions (North America, Europe and Asia) and the main countries (United States, Germany, Japan and China). (sbwire.com)

Our data show that exposure to ceftazidime-avibactam can lead to changes in OXA-48, resulting in increased ability to hydrolyze ceftazidime and withstand the inhibitory effect of avibactam. (unboundmedicine.com)
We have discovered that this insertion enables OXA-146 to bind and hydrolyze ceftazidime with efficiency comparable to other extended spectrum class D beta-lactamases. (gvsu.edu)

The clinical and bacteriological responses to ceftazidime (1 g every 8 h) versus meropenem (0.5 g every 8 h) were assessed in hospitalized patients (257 men, 152 women) with community-acquired pneumonia, according to risk factors. (janusinfo.se)
Ceftazidime was used to treat dairy cows with clinical signs of inflammation in 1 mammary gland quarter and presence of 1 or more pathogenic microorganisms in that quarter (3 intramammary doses of 200 mg/quarter/12 h) 17 . (scielo.org.za)

However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving ceftazidime injection. (drugs.com)
No patients have reported taking Ceftazidime-Avibactam. (patientslikeme.com)
In patients with community-acquired pneumonia, the response to ceftazidime was similar in men and women. (janusinfo.se)
A population pharmacokinetic approach to ceftazidime use in burn patients: influence of glomerular filtration, gender and mechanical ventilation. (janusinfo.se)
Ceftazidime is contraindicated in patients with known allergy to the cephalosporin group of antibiotics. (pediatriconcall.com)
What I will be trying to evaluate as I delve further into the research that I did [the effects of treatments on] patients who received ceftazidime-avibactam by itself versus with other agents. (contagionlive.com)
At baseline, 108/382 (28.3%) of patients in the microbiological intent-to-treat (micro-ITT) population, which included all patients with positive culture results indicating the presence of at least one Gram-negative pathogen, had Gram-negative isolates that were not susceptible to ceftazidime, including 53 patients with K. pneumoniae and 28 patients with P. aeruginosa isolates. (allergan.com)
This study highlights the peculiarities of ceftazidime pharmacokinetics in burn patients with high interindividual variability. (biomedcentral.com)
Patients receiving ceftazidime showed a tendency for a greater long-term benefit in lung function as measured at 1 and 2 months after treatment than patients receiving the other antibiotics. (mysciencework.com)

Ceftolozane/tazobactam and ceftazidime/avibactam are two new cephalosporin and β-lactamase inhibitor combinations with recent US Food and Drug Administration approvals for the treatment of cIAI in combination with metronidazole. (dovepress.com)

Like all known class D carbapenemases, OXA-23 cannot bind or hydrolyze the cephalosporin ceftazidime. (gvsu.edu)

The sodium carbonate at a concentration of 118 mg/g of ceftazidime activity has been admixed to facilitate dissolution. (rxlist.com)

During pregnancy, renal clearance of ceftazidime has been shown to be higher, 39% during first trimester and 65 % during third trimester, than post-partum. (janusinfo.se)
Nathorst-Böös J, Philipson A, Hedman A, Arvisson A. Renal elimination of ceftazidime during pregnancy. (janusinfo.se)

Focus on ceftriaxone, ceftazidime and cefotaxime. (alfa.com)

The MIC 90 values of ceftazidime determined for E. coli, Salmonella spp. (scielo.org.za)

Avibactam, a non-β-lactam β-lactamase inhibitor, has been combined with ceftaroline or ceftazidime but these two combinations have not been directly compared. (ovid.com)
Results: Avibactam, at a concentration of 1-2 mg/L, produced maximum bacterial clearance over 72 h for the E. coli and E. cloacae strains with both ceftaroline and ceftazidime. (ovid.com)

Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum β-lactamase (ESBL) or AmpC enzyme and also against most Klebsiella spp. (asm.org)

What is the definition or description of: Ceptaz (ceftazidime) allergy? (healthtap.com)

You should begin to feel better during the first few days of treatment with ceftazidime injection. (medlineplus.gov)
[ 1 ] Ceftazidime-avibactam was first approved in 2015 for adults with cIAI and cUTI, and was subsequently approved for the treatment of hospital-acquired or ventilator-associated pneumonia in February 2018. (medscape.com)
Data from 2 randomized, multicenter trials support the use of ceftazidime in combination with tobramycin for the treatment of acute pulmonary exacerbations of cystic fibrosis [Hubert 2009] , [Latzin 2008] . (drugs.com)
Using ceftazidime with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. (drugs.com)
An open randomised trial was conducted to compare ceftazidime (120 mg/kg/day) with "conventional therapy" (chloramphenicol 100 mg/kg/day, doxycycline 4 mg/kg/day, trimethoprim 10 mg/kg/day, and sulphamethoxazole 50 mg/kg/day) in the treatment of severe melioidosis. (nih.gov)
Ceftazidime vs. amoxicillin/clavulanate in the treatment of severe melioidosis. (nih.gov)
An open, paired, randomized, controlled trial of high-dose parenteral ceftazidime (120 mg/[kg.d]) vs. amoxicillin/clavulanate (160 mg/[kg.d]) for the treatment of severe melioidosis was conducted in Ubon Ratchatani in northeastern Thailand. (nih.gov)
Parenteral amoxicillin/clavulanate is a safe and effective initial treatment, but parenteral ceftazidime remains the treatment of choice for severe melioidosis. (nih.gov)
Pneumonia: the impact of risk factors on the outcome of treatment with meropenem and ceftazidime. (janusinfo.se)
In response, combinations of existing β-lactams and novel β-lactamase inhibitors, such as ceftazidime-avibactam (CAZ-AVI), have been developed as alternative treatment options. (unboundmedicine.com)
She started in-patient treatment for a pulmonary exacerbation and was initiated on a 14 day course of IV ceftazidime 3g [frequency not stated] and colistimethate sodium. (deepdyve.com)
It is shown that administration of gentamicin in combination with ceftazidime in the free form either as single dose or as 5-day treatment resulted in an additive effect on rat survival in both models. (aspetjournals.org)
Consequently, liposome coencapsulation of gentamicin and ceftazidime allowed both a shorter course of treatment at lower cumulative doses compared with administration of the antibiotics in the free form to obtain complete survival of rats. (aspetjournals.org)
We conclude that the currently recommended dosage of 25 mg of ceftazidime per kg twice daily for preterm infants with gestational ages below 32 weeks may be adjusted during the first days of life to one daily dose at 25 mg/kg, provided that for the empirical treatment of septicemia, amoxicillin at 25 mg/kg is also given twice daily. (eur.nl)
This is my fourth course of treatment with Ceftazidime in the last 5 months. (medschat.com)
One case of Type III hypersensitivity reaction was seen during ceftazidime treatment. (mysciencework.com)

The safety and efficacy of Ceftazidime administered as continuous infusion to neonates and infants ≤ 2 months has not been established. (medicines.org.uk)

A search of PubMed using the terms "ceftazidime," "avibactam," "NXL104," and "AVE1330A" was performed. (unboundmedicine.com)
DATA SOURCES: A search of PubMed using the terms "ceftazidime," "avibactam," "NXL104," and "AVE1330A" was performed. (unboundmedicine.com)

Avibactam is a first-in-class non-beta-lactam beta-lactamase inhibitor which protects ceftazidime against degradation by certain beta-lactamases. (salesandmarketingnetwork.com)

The pharmacokinetic profile of ceftazidime-avibactam was evaluated as part of a phase 1 safety and tolerability study conducted in 32 children. (medscape.com)

Ceftazidime is a semisynthetic, broad-spectrum, beta-lactam antibacterial drug for parenteral administration. (rxlist.com)
Ceftazidime is a semisynthetic, beta-lactam antibacterial drug. (rxlist.com)

Ceftazidime injection is in a class of medications called cephalosporin antibiotics. (medlineplus.gov)
Hypersensitivity to ceftazidime or to the cephalosporin antibiotics or to any ingredient of the drug. (lekhim.ua)

When you are receiving ceftazidime, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. (drugs.com)
What should I discuss with my healthcare provider before using avibactam and ceftazidime? (rexhealth.com)

Clinically relevant organisms against which ceftazidime has activity include: Gram-negative aerobes such as Enterobacter, Escherichia coli, Haemophilus influenzae, Klebsiella spp. (wikipedia.org)

Rare but more serious allergic reactions, such as toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme, have been reported with this class of antibiotics, including ceftazidime. (wikipedia.org)
Do not take ceftazidime if you are allergic to ceftazidime or to any of its ingredients. (rxwiki.com)

Ceftazidime is in a group of drugs called cephalosporin (SEF a low spor in) antibiotics. (peacehealth.org)

Anti-inflammatory effects of the antibiotics ceftazidime and tobramycin in porcine endotoxin shock : are they really anti-inflammatory? (diva-portal.org)
The difference in lung function improvement was statistically better in terms of FEV1 and FVC for the ceftazidime group in the study versus tobramycin plus carbenicillin. (mysciencework.com)

Organisms11

Diseases11

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes6

Health Care1

Clindamycin suppresses endotoxin released by ceftazidime-treated Escherichia coli O55:B5 and subsequent production of tumor necrosis factor alpha and interleukin-1 beta. (1/736)

Molecular basis of AmpC hyperproduction in clinical isolates of Escherichia coli. (2/736)

Laboratory mutants of OXA-10 beta-lactamase giving ceftazidime resistance in Pseudomonas aeruginosa. (3/736)

Piperacillin/tazobactam plus tobramycin versus ceftazidime plus tobramycin for the treatment of patients with nosocomial lower respiratory tract infection. Piperacillin/tazobactam Nosocomial Pneumonia Study Group. (4/736)

In-vitro susceptibility of 1982 respiratory tract pathogens and 1921 urinary tract pathogens against 19 antimicrobial agents: a Canadian multicentre study. Canadian Antimicrobial Study Group. (5/736)

Antibiotic dosing issues in lower respiratory tract infection: population-derived area under inhibitory curve is predictive of efficacy. (6/736)

A resuscitated case from asphyxia by large bronchial cast. (7/736)

Survey of extended-spectrum beta-lactamases in clinical isolates of Escherichia coli and Klebsiella pneumoniae: prevalence of TEM-52 in Korea. (8/736)

Ceftazidime

Cephalosporins

beta-Lactamases

Aztreonam

Microbial Sensitivity Tests

Anti-Bacterial Agents

Pseudomonas aeruginosa

Cephalosporin Resistance

Cefotaxime

Thienamycins

beta-Lactams

Amikacin

Imipenem

Monobactams

Piperacillin

Pseudomonas Infections

Klebsiella pneumoniae

Gram-Negative Bacteria

Penicillanic Acid

Melioidosis

Cefoperazone

Azabicyclo Compounds

beta-Lactam Resistance

Drug Resistance, Microbial

Enterobacteriaceae

Tobramycin

Burkholderia pseudomallei

Enterobacteriaceae Infections

Klebsiella Infections

Enterobacter cloacae

Bronchopneumonia

Bacterial Infections

Clavulanic Acid

Gram-Negative Bacterial Infections

Ciprofloxacin

Moxalactam

Cephalosporinase

Isoelectric Focusing

Serum Bactericidal Test

Drug Therapy, Combination

Agranulocytosis

Carbapenems

Bacteria

Drug Resistance, Bacterial

Ceftriaxone

Half-Life

Lactams

Drug Resistance, Multiple, Bacterial

Escherichia coli

Sulbactam

Gram-Positive Bacteria

Fever

Home Infusion Therapy

Enterobacter

Endophthalmitis

Klebsiella

Ticarcillin

Infusions, Intravenous

Injections, Intravenous

Penicillins

Gentamicins

Drug Incompatibility

Cefsulodin

Cross Infection

Clindamycin suppresses endotoxin released by ceftazidime-treated Escherichia coli O55:B5 and subsequent production of tumor necrosis factor alpha and interleukin-1 beta. (1/736)

Molecular basis of AmpC hyperproduction in clinical isolates of Escherichia coli. (2/736)

Laboratory mutants of OXA-10 beta-lactamase giving ceftazidime resistance in Pseudomonas aeruginosa. (3/736)

Piperacillin/tazobactam plus tobramycin versus ceftazidime plus tobramycin for the treatment of patients with nosocomial lower respiratory tract infection. Piperacillin/tazobactam Nosocomial Pneumonia Study Group. (4/736)

In-vitro susceptibility of 1982 respiratory tract pathogens and 1921 urinary tract pathogens against 19 antimicrobial agents: a Canadian multicentre study. Canadian Antimicrobial Study Group. (5/736)

Antibiotic dosing issues in lower respiratory tract infection: population-derived area under inhibitory curve is predictive of efficacy. (6/736)

A resuscitated case from asphyxia by large bronchial cast. (7/736)

Survey of extended-spectrum beta-lactamases in clinical isolates of Escherichia coli and Klebsiella pneumoniae: prevalence of TEM-52 in Korea. (8/736)

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