A semisynthetic cephamycin antibiotic resistant to beta-lactamase.
Naturally occurring family of beta-lactam cephalosporin-type antibiotics having a 7-methoxy group and possessing marked resistance to the action of beta-lactamases from gram-positive and gram-negative organisms.
Gram-negative bacteria occurring in the lower intestinal tracts of man and other animals. It is the most common species of anaerobic bacteria isolated from human soft tissue infections.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
A cephalosporin antibiotic.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.
Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.
Substances that reduce the growth or reproduction of BACTERIA.
Cephalosporinase is an enzyme produced by bacteria that inactivates cephalosporin antibiotics, rendering them ineffective against bacterial infections.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate.
Anaerobic bacteria are microorganisms that do not require oxygen to survive and can cause infections in oxygen-poor environments.
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.
An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.
Semisynthetic broad-spectrum cephalosporin.
Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.
Infections with bacteria of the genus BACTEROIDES.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.
Gram-negative gas-producing rods found in feces of humans and other animals, sewage, soil, water, and dairy products.
Infections by bacteria, general or unspecified.
Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in the intestines of humans and a wide variety of animals, as well as in manure, soil, and polluted waters. Its species are pathogenic, causing urinary tract infections and are also considered secondary invaders, causing septic lesions at other sites of the body.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.
Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
A genus of gram-negative, anaerobic, rod-shaped bacteria found in cavities of humans and other animals. No endospores are formed. Some species are pathogenic and occur in various purulent or gangrenous infections.
An antibiotic derived from penicillin similar to CARBENICILLIN in action.
A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.
Non-susceptibility of an organism to the action of the cephalosporins.
A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Formularies concerned with pharmaceuticals prescribed in hospitals.
A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)
Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.
A method where a culturing surface inoculated with microbe is exposed to small disks containing known amounts of a chemical agent resulting in a zone of inhibition (usually in millimeters) of growth of the microbe corresponding to the susceptibility of the strain to the agent.
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-.
Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.
Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.
Hospital Bed Capacity, 500 and over refers to the total number of hospital beds available in facilities with 500 or more beds.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in soil, fecal matter, and sewage. It is an opportunistic pathogen and causes cystitis and pyelonephritis.

Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes. (1/339)

We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to cefoxitin in Klebsiella pneumoniae. This mechanism also operates in vivo: of 13 porin-deficient cefoxitin-resistant clinical isolates of K. pneumoniae, 4 presented ISs in their ompK36 gene.  (+info)

Carbapenem resistance in Escherichia coli associated with plasmid-determined CMY-4 beta-lactamase production and loss of an outer membrane protein. (2/339)

Three cefoxitin-resistant Escherichia coli isolates from stool specimens of a patient with leukemia were either resistant, intermediate, or sensitive to imipenem. Conjugation experiments showed that cefoxitin resistance, but not imipenem resistance, was transferable. All isolates were shown by isoelectric focusing to produce two beta-lactamases with isoelectric points of 5.4 (TEM-1, confirmed by sequencing of a PCR product) and >8.5 (consistent with a class C beta-lactamase). The gene coding for the unknown beta-lactamase was cloned and sequenced and revealed an enzyme which had 99.9% sequence identity with the plasmid-determined class C beta-lactamase CMY-2. The cloned beta-lactamase gene differed from blaCMY-2 at one nucleotide position that resulted in an amino acid change, tryptophan to arginine at position 221. We propose that this enzyme be designated CMY-4. Both the imipenem-resistant and -intermediate isolates lacked a 38-kDa outer membrane protein (OMP) that was present in the imipenem-sensitive isolate. The lack of an OMP alone did not explain the difference in carbapenem susceptibilities observed. However, measurement of beta-lactamase activities (including measurements under conditions where TEM-1 beta-lactamase was inhibited) indicated that the imipenem-intermediate isolate expressed six- to eightfold less beta-lactamase than did the other isolates. This study illustrates that carbapenem resistance in E. coli can arise from high-level expression of plasmid-mediated class C beta-lactamase combined with an OMP deficiency. Furthermore, in the presence of an OMP deficiency, the level of expression of a plasmid-mediated class C beta-lactamase is an important factor in determining whether E. coli isolates are fully resistant to carbapenems.  (+info)

Comparison of the in vitro activity of Bay k 4999 and piperacillin, two new antipseudomonal broad-spectrum penicillins, with other beta-lactam drugs. (3/339)

Bay k 4999 and piperacillin, two new substituted ampicillins, were compared with other beta-lactam antibiotics, including carbenicillin, azlocillin, mezlocillin, benzylpenicillin, ampicillin, and cefoxitin, against a wide range of gram-positive and -negative organisms. Bay k 4999 and piperacillin were extremely active against Pseudomonas aeruginosa (50% inhibited by 2 mug/ml), being about 16-fold more active than carbenicillin. Bay k 4999 was the most active drug against Escherichia coli (50% inhibited by 0.5 mug/ml) and Klebsiella spp. (50% inhibited by 2 mug/ml). Piperacillin and Bay k 4999 were equally active against Proteus spp., and piperacillin had high activity against Bacteroides fragilis (50% inhibited by between 1 and 2 mug/ml).  (+info)

Multisite reproducibility of results obtained by the broth microdilution method for susceptibility testing of Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium fortuitum. (4/339)

A multicenter study was conducted to assess the interlaboratory reproducibility of broth microdilution testing of the more common rapidly growing pathogenic mycobacteria. Ten isolates (four Mycobacterium fortuitum group, three Mycobacterium abscessus, and three Mycobacterium chelonae isolates) were tested against amikacin, cefoxitin, ciprofloxacin, clarithromycin, doxycycline, imipenem, sulfamethoxazole, and tobramycin (M. chelonae only) in four laboratories. At each site, isolates were tested three times on each of three separate days (nine testing events per isolate) with a common lot of microdilution trays. Agreement among MICs (i.e., mode +/- 1 twofold dilution) varied considerably for the different drug-isolate combinations and overall was best for cefoxitin (91.7 and 97.2% for one isolate each and 100% for all others), followed by doxycycline, amikacin, and ciprofloxacin. Agreement based on the interpretive category, using currently suggested breakpoints, also varied and overall was best for doxycycline (97.2% for one isolate and 100% for the rest), followed by ciprofloxacin and clarithromycin. Reproducibility among MICs and agreement by interpretive category was most variable for imipenem. Based on results reported from the individual sites, it appears that inexperience contributed significantly to the wide range of MICs of several drugs, especially clarithromycin, ciprofloxacin, and sulfamethoxazole. New interpretive guidelines are presented for the testing of M. fortuitum against clarithromycin; M. abscessus and M. chelonae against the aminoglycosides; and all three species against cefoxitin, doxycycline, and imipenem.  (+info)

Survey of extended-spectrum beta-lactamases in clinical isolates of Escherichia coli and Klebsiella pneumoniae: prevalence of TEM-52 in Korea. (5/339)

Two hundred ninety isolates of Escherichia coli were investigated for the production of extended-spectrum beta-lactamases (ESBLs). Fourteen (4.8%) of the 290 strains were found to produce ESBLs. Each of the 14 strains produced one or two ESBLs, as follows: 10 strains produced TEM-52, 1 strain produced SHV-2a, 1 strain produced SHV-12, 1 strain produced a CMY-1-like enzyme, and 1 strain expressed SHV-2a and a CMY-1-like enzyme. Another two strains for which the MICs of ceftazidime and cefoxitin were high, were probable AmpC enzyme hyperproducers. Because of the high prevalence of TEM-52 in E. coli isolates, we further investigated the TEM-type ESBLs produced by Klebsiella pneumoniae in order to observe the distribution of TEM-52 enzymes among Enterobacteriaceae in Korea. All TEM enzymes produced by 12 strains of K. pneumoniae were identified as TEM-52. To evaluate the genetic relatedness among the organisms, ribotyping of TEM-52-producing E. coli and K. pneumoniae was performed. The ribotyping profiles of the organisms showed similar but clearly different patterns. In conclusion, TEM-52 is the most prevalent TEM-type ESBL in Korea.  (+info)

In-vitro susceptibilities of species of the Bacteroides fragilis group to newer beta-lactam agents. (6/339)

The in-vitro activities of imipenem and four beta-lactam-beta-lactamase inhibitor combinations were tested against 816 strains of the Bacteroides fragilis group, and compared with other anti-anaerobic agents. None of the strains was resistant to metronidazole, and only one was resistant to chloramphenicol. Mezlocillin and piperacillin were moderately active, while clindamycin was the least active. Rates of resistance varied between various species. The new beta-lactam agents tested showed excellent activity; piperacillin-tazobactam and imipenem were the most active. The emergence of strains that are resistant to these agents, observed in this study, suggests there is a need to perform periodic antimicrobial susceptibility tests.  (+info)

Occurrence and detection of AmpC beta-lactamases among Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates at a veterans medical center. (7/339)

AmpC beta-lactamases are cephalosporinases that confer resistance to a wide variety of beta-lactam drugs and that may thereby create serious therapeutic problems. Although reported with increasing frequency, the true rate of occurrence of AmpC beta-lactamases in Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis remains unknown. We tested a total of 1,286 consecutive, nonrepeat isolates of these three species and found that, overall, 45 (3.5%) yielded a cefoxitin zone diameter less than 18 mm (screen positive) and that 16 (1.2%) demonstrated AmpC bands by isoelectric focusing. Based on the species, of 683 E. coli, 371 K. pneumoniae, and 232 P. mirabilis isolates tested, 13 (1.9%), 28 (7.6%), and 4 (1.7%), respectively, demonstrated decreased zone diameters and 11 (1.6%), 4 (1.1%), and 1 (0.4%), respectively, demonstrated AmpC bands. Cefoxitin resistance was transferred for all but 8 (E. coli) of the 16 AmpC producers. We also describe a three-dimensional extract test, which was used to detect phenotypically isolates that harbor AmpC beta-lactamase. Of the 45 cefoxitin-resistant isolates, the three-dimensional extract test accurately identified all 16 AmpC producers and 28 of 29 (97%) isolates as non-AmpC producers. Interestingly, most (86%) isolates in the latter group were K. pneumoniae isolates. These data confirm that, at our institution, E. coli, K. pneumoniae, and P. mirabilis harbor plasmid-mediated AmpC enzymes.  (+info)

Susceptibility of clinical isolates of Bacteroides fragilis group strains to cefoxitin, cefoperazone and ticarcillin/clavulanate. (8/339)

A total of 40 strains of the B. fragilis group was isolated from clinical specimens in two hospital centers in Fortaleza from 1993 to 1997. The most frequently isolated species was Bacteroides fragilis (19 strains) and most isolates came from intra-abdominal and wound infections. The susceptibility profile was traced for cefoxitin, cefoperazone and ticarcillin-clavulanate by using the agar dilution reference method. All isolates were susceptible to ticarcillin-clavulanate (128/2 microg/ml). Resistance rates of 15 and 70% were detected to cefoxitin (64 microg/ml) and cefoperazone (64 microg/ml), respectively. Such regional results permit a better orientation in choosing this group of antibiotics for prophylaxis and therapy especially in relation to cefoxitin, which is frequently used in the hospital centers studied.  (+info)

Cefoxitin is an antibiotic medication that is used to treat a variety of bacterial infections. It is a member of the cephalosporin class of antibiotics, which work by inhibiting the growth of bacteria. Cefoxitin is typically used to treat infections of the skin, respiratory tract, urinary tract, and abdomen. It is usually given intravenously, although it can also be given by mouth in some cases. Cefoxitin is generally well-tolerated, but like all antibiotics, it can cause side effects such as nausea, diarrhea, and allergic reactions. It is important to take cefoxitin exactly as prescribed by a healthcare provider in order to ensure that it is effective and to minimize the risk of side effects.

Cephamycins are a class of semi-synthetic antibiotics that are derived from cephalosporins. They are used to treat a variety of bacterial infections, including respiratory tract infections, skin infections, and urinary tract infections. Cephamycins work by inhibiting the growth of bacteria by interfering with their ability to synthesize cell walls. They are generally well-tolerated and have a broad spectrum of activity against many types of bacteria. However, like all antibiotics, cephamycins can cause side effects and may not be effective against all types of bacteria.

Bacteroides fragilis is a gram-negative, anaerobic bacterium that is commonly found in the human gut microbiota. It is a member of the Bacteroides genus, which is one of the most abundant groups of bacteria in the human gut. In the medical field, Bacteroides fragilis is often associated with infections, particularly in patients with weakened immune systems or underlying medical conditions. It can cause a range of infections, including pneumonia, sepsis, and abscesses, particularly in the abdomen and pelvis. Bacteroides fragilis is also known to produce a toxin called fragilysin, which can contribute to the pathogenesis of infections caused by this bacterium. Treatment of Bacteroides fragilis infections typically involves antibiotics, although the choice of antibiotic may depend on the specific strain of the bacterium and the severity of the infection.

Cephalosporins are a class of antibiotics that are derived from the mold species Cephalosporium acremonium. They are commonly used to treat a wide range of bacterial infections, including respiratory tract infections, skin infections, urinary tract infections, and infections of the bones and joints. Cephalosporins work by inhibiting the synthesis of bacterial cell walls, which leads to the death of the bacteria. They are generally well-tolerated and have a broad spectrum of activity against many types of bacteria. There are several different classes of cephalosporins, each with its own specific characteristics and uses. The most commonly used classes are first-generation cephalosporins, second-generation cephalosporins, third-generation cephalosporins, and fourth-generation cephalosporins. The choice of which cephalosporin to use depends on the type of infection being treated, the severity of the infection, and the specific characteristics of the bacteria causing the infection.

Cefotetan is an antibiotic medication that belongs to the class of drugs called cephalosporins. It is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, and skin infections. Cefotetan works by inhibiting the growth of bacteria, which helps to stop the infection from spreading. It is typically administered intravenously (into a vein) and is usually given in a hospital setting. It is important to note that cefotetan may not be effective against all types of bacteria, and it is important to take the full course of the medication as prescribed by a healthcare provider to ensure that the infection is fully treated.

Cephalothin is an antibiotic medication that belongs to the penicillin group of drugs. It is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, and skin infections. Cephalothin is typically administered intravenously or intramuscularly, and it works by inhibiting the growth and reproduction of bacteria. It is important to note that cephalothin may not be effective against all types of bacteria, and it can also cause side effects such as allergic reactions, nausea, and diarrhea.

Cefmetazole is an antibiotic medication that belongs to the class of drugs called cephalosporins. It is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, skin infections, and infections of the bones and joints. Cefmetazole is typically administered intravenously, although it may also be available in an oral form. It works by inhibiting the growth of bacteria, thereby helping to eliminate the infection. Like other cephalosporins, cefmetazole is effective against a wide range of Gram-positive and Gram-negative bacteria, including many that are resistant to other antibiotics. However, it is important to note that cefmetazole may not be effective against all types of bacteria, and it is important to use the medication as directed by a healthcare provider.

Moxalactam is an antibiotic medication that is used to treat certain types of bacterial infections. It is a member of a class of antibiotics called the beta-lactam antibiotics, which work by inhibiting the production of bacterial cell walls, leading to bacterial cell death. Moxalactam is typically used to treat infections of the respiratory tract, urinary tract, and skin and soft tissues. It is usually administered intravenously, although it is also available in an oral form. Moxalactam is not effective against all types of bacteria, and it may not be appropriate for everyone. It is important to discuss the potential benefits and risks of moxalactam with a healthcare provider before starting treatment.

Anti-bacterial agents, also known as antibiotics, are medications that are used to treat bacterial infections. They work by killing or inhibiting the growth of bacteria, thereby preventing the spread of the infection. There are several types of anti-bacterial agents, including: 1. Penicillins: These are the first antibiotics discovered and are effective against a wide range of bacteria. 2. Cephalosporins: These are similar to penicillins and are effective against many of the same types of bacteria. 3. Macrolides: These antibiotics are effective against bacteria that are resistant to other antibiotics. 4. Tetracyclines: These antibiotics are effective against a wide range of bacteria and are often used to treat acne. 5. Fluoroquinolones: These antibiotics are effective against a wide range of bacteria and are often used to treat respiratory infections. It is important to note that antibiotics are only effective against bacterial infections and are not effective against viral infections such as the common cold or flu. Additionally, overuse or misuse of antibiotics can lead to the development of antibiotic-resistant bacteria, which can be more difficult to treat.

Cephalosporinase is an enzyme produced by certain bacteria that is responsible for breaking down cephalosporin antibiotics, rendering them ineffective. This enzyme is classified as a beta-lactamase, which is a type of enzyme that hydrolyzes the beta-lactam ring of antibiotics, including cephalosporins, penicillins, and monobactams. Cephalosporinase is often found in Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The production of cephalosporinase is one mechanism by which bacteria can become resistant to cephalosporin antibiotics. The presence of cephalosporinase in a bacterial isolate is typically detected using a beta-lactamase detection test, such as the Modified Hodge Test or the Cephalosporin Inhibition Test. If cephalosporinase is detected, it may indicate that the bacteria are resistant to cephalosporin antibiotics and that alternative antibiotics may be needed to treat the infection.

Beta-lactamases are enzymes produced by certain bacteria that are responsible for breaking down beta-lactam antibiotics, which are a class of antibiotics that include penicillins, cephalosporins, and monobactams. These enzymes hydrolyze the beta-lactam ring of the antibiotic, rendering it inactive and unable to kill the bacteria. The production of beta-lactamases is a common mechanism of antibiotic resistance in bacteria, and it has become a major problem in the treatment of bacterial infections. Bacteria that produce beta-lactamases are often referred to as "beta-lactamase-producing organisms" or "BLPOs." There are different types of beta-lactamases, and they can be classified based on their substrate specificity, molecular weight, and resistance profile. Some beta-lactamases are specific for a particular class of beta-lactam antibiotics, while others are more broad-spectrum and can hydrolyze multiple classes of antibiotics. The detection and characterization of beta-lactamases is important for the appropriate selection and use of antibiotics in the treatment of bacterial infections. In addition, the development of new antibiotics that are resistant to beta-lactamases is an ongoing area of research in the medical field.

Cefamandole is an antibiotic medication that belongs to the cephalosporin class of drugs. It is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, skin infections, and infections of the bones and joints. Cefamandole is typically administered intravenously, although it can also be given orally in some cases. It works by inhibiting the growth of bacteria by interfering with their ability to make cell walls. Like other cephalosporins, cefamandole is effective against a wide range of Gram-negative and Gram-positive bacteria, including many that are resistant to other antibiotics. However, it is important to note that cefamandole can also cause side effects, such as nausea, vomiting, diarrhea, and allergic reactions, and it may not be suitable for everyone.

Anaerobic bacteria are a group of microorganisms that do not require oxygen to survive and grow. They are commonly found in environments that are low in oxygen, such as the human digestive tract, soil, and water. Anaerobic bacteria can be either obligate anaerobes, which means they cannot survive in the presence of oxygen, or facultative anaerobes, which can survive in both oxygen-rich and oxygen-poor environments. In the medical field, anaerobic bacteria are often associated with infections, particularly those that occur in the gastrointestinal tract, female reproductive system, and oral cavity. Some common examples of anaerobic bacteria that can cause infections include Bacteroides fragilis, Clostridium difficile, and Peptostreptococcus micros. These bacteria can cause a range of infections, from mild to severe, and can be difficult to treat because they are resistant to many antibiotics.

Beta-Lactams are a class of antibiotics that are derived from the beta-lactam ring structure. They are one of the most widely used classes of antibiotics and are effective against a broad range of bacterial infections. The beta-lactam ring is a six-membered ring with a beta-hydroxy group and an amide group. The beta-lactam antibiotics work by inhibiting the synthesis of the bacterial cell wall, which leads to cell lysis and death. There are several subclasses of beta-lactam antibiotics, including penicillins, cephalosporins, monobactams, and carbapenems. Each subclass has its own unique properties and is effective against different types of bacteria. Beta-lactam antibiotics are often used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, skin infections, and infections of the respiratory, gastrointestinal, and genitourinary tracts. They are generally well-tolerated and have a low risk of side effects, although allergic reactions can occur in some people.

Bacteroides is a genus of Gram-negative, rod-shaped bacteria that are commonly found in the human gut microbiota. They are one of the most abundant bacterial groups in the human colon and play an important role in the digestion of complex carbohydrates. Bacteroides are known for their ability to break down complex polysaccharides, such as cellulose and pectin, into simpler sugars that can be absorbed by the body. They also produce short-chain fatty acids, such as butyrate, propionate, and acetate, which are important for maintaining gut health and regulating the immune system. In the medical field, Bacteroides are sometimes associated with certain diseases, such as periodontitis (gum disease) and colorectal cancer. However, most strains of Bacteroides are considered to be harmless or even beneficial to human health. In fact, some strains of Bacteroides are being studied for their potential use in probiotics and other therapeutic applications.

Oxacillin is a type of antibiotic medication that is used to treat a variety of bacterial infections. It is a beta-lactam antibiotic, which means that it works by inhibiting the production of bacterial cell walls, leading to the death of the bacteria. Oxacillin is commonly used to treat skin infections, respiratory infections, urinary tract infections, and other types of bacterial infections. It is often prescribed for patients who are allergic to penicillin, as it is a close relative of penicillin and is less likely to cause an allergic reaction. It is important to note that oxacillin is only effective against bacterial infections and will not work against viral infections such as the common cold or flu. Additionally, it is important to take oxacillin exactly as prescribed by a healthcare provider to ensure that it is effective and to prevent the development of antibiotic resistance.

Cefotaxime is an antibiotic medication that is used to treat a variety of bacterial infections, including pneumonia, meningitis, urinary tract infections, and gonorrhea. It is a cephalosporin antibiotic, which means that it works by stopping the growth of bacteria. Cefotaxime is typically administered intravenously, although it may also be available as an oral medication. It is important to note that cefotaxime is only effective against bacterial infections and will not work against viral infections. It is also important to follow the dosing instructions provided by your healthcare provider and to complete the full course of treatment, even if you start to feel better before the medication is finished.

Cefoperazone is an antibiotic medication used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, and skin infections. It is a cephalosporin antibiotic, which means it works by stopping the growth of bacteria. Cefoperazone is usually given intravenously (into a vein) or intramuscularly (into a muscle) and is often used in combination with another antibiotic called sulbactam to increase its effectiveness against certain types of bacteria. It is important to note that antibiotics like cefoperazone are only effective against bacterial infections and will not work against viral infections like the flu or a cold.

Bacteroides infections are a type of bacterial infection caused by the bacterium Bacteroides fragilis or other species of the Bacteroides genus. These bacteria are commonly found in the human gut and are usually harmless, but in some cases, they can cause infections in other parts of the body. Bacteroides infections can occur in a variety of locations, including the respiratory tract, urinary tract, skin, and soft tissues. They can also cause infections in the bloodstream, which can be life-threatening if left untreated. Symptoms of Bacteroides infections can vary depending on the location of the infection, but may include fever, chills, fatigue, pain, and swelling. In some cases, the infection may be asymptomatic and only discovered through routine medical testing. Diagnosis of Bacteroides infections typically involves culture and identification of the bacteria from a sample of the infected tissue or fluid. Treatment typically involves antibiotics, although the specific antibiotic used may depend on the location and severity of the infection. It is important to note that Bacteroides infections are relatively uncommon and are usually only seen in people with weakened immune systems or other underlying medical conditions. However, they can be serious and should be treated promptly by a healthcare professional.

Ceftizoxime is an antibiotic medication that is used to treat a variety of bacterial infections, including pneumonia, bronchitis, urinary tract infections, and skin infections. It is a cephalosporin antibiotic, which means it works by stopping the growth of bacteria. Ceftizoxime is typically given intravenously (into a vein) or intramuscularly (into a muscle) and is usually administered for a period of 7 to 14 days. It is important to note that ceftizoxime may not be effective against all types of bacteria, and it is important to take the full course of the medication as prescribed by a healthcare provider to ensure that the infection is fully treated.

Clindamycin is an antibiotic medication that is used to treat a variety of bacterial infections. It is a lincosamide antibiotic that works by stopping the growth of bacteria. Clindamycin is often used to treat infections of the skin, respiratory tract, and reproductive system, as well as certain types of bacterial infections that are resistant to other antibiotics. It is usually taken by mouth or given by injection, depending on the type and severity of the infection being treated. Clindamycin can cause side effects such as nausea, diarrhea, and stomach pain, and it may interact with other medications, so it is important to follow your healthcare provider's instructions carefully when taking this medication.

Probenecid is a medication that is used to treat gout and to prevent the formation of kidney stones. It works by blocking the reabsorption of uric acid in the kidneys, which helps to lower the levels of uric acid in the blood. Probenecid is usually taken in combination with allopurinol, another medication that helps to lower uric acid levels. It is available in tablet form and is usually taken two to three times a day. Common side effects of probenecid include nausea, vomiting, and stomach pain. It is important to follow the dosage instructions provided by your healthcare provider and to let them know if you experience any side effects while taking this medication.

Imipenem is a broad-spectrum antibiotic that is used to treat a variety of bacterial infections. It is a member of the carbapenem class of antibiotics, which are known for their effectiveness against multidrug-resistant bacteria. Imipenem is typically administered intravenously and is used to treat infections of the respiratory tract, urinary tract, skin and soft tissues, and the bloodstream. It is also sometimes used to treat infections of the abdomen, including those caused by bacteria that are resistant to other antibiotics. Imipenem works by inhibiting the production of bacterial cell walls, which leads to the death of the bacteria. It is a broad-spectrum antibiotic, meaning that it is effective against a wide range of bacteria, including both gram-positive and gram-negative bacteria. However, like all antibiotics, imipenem can cause side effects, including nausea, vomiting, diarrhea, and allergic reactions. It is important to take imipenem exactly as prescribed by a healthcare provider and to notify them if any side effects occur.

Lactams are a class of organic compounds that contain a six-membered ring with an amide group (-CONH-) attached to one of the carbon atoms. They are commonly found in nature and are also synthesized in the laboratory for use in medicine. In the medical field, lactams are used as antibiotics to treat a variety of bacterial infections. The most well-known lactam antibiotics are penicillins, which contain a beta-lactam ring. Other examples of lactam antibiotics include cephalosporins, monobactams, and carbapenems. Lactams are effective against a wide range of bacteria, including gram-positive and gram-negative bacteria. They work by inhibiting the production of cell walls in bacteria, leading to cell lysis and death. However, like all antibiotics, lactams can also have side effects and can lead to the development of antibiotic resistance if not used properly.

Bacterial infections are caused by bacteria, which are single-celled microorganisms that can be found almost everywhere in the environment, including on our skin and in our digestive tracts. When bacteria enter the body and multiply, they can cause illness and disease. Bacterial infections can affect any part of the body and can range from mild to severe. Some common examples of bacterial infections include strep throat, urinary tract infections, pneumonia, meningitis, and skin infections. Bacterial infections can be treated with antibiotics, which are medications that kill or inhibit the growth of bacteria. However, it is important to use antibiotics properly and only when necessary, as overuse can lead to antibiotic resistance, which makes it more difficult to treat bacterial infections in the future.

Bacteria are single-celled microorganisms that are found in almost every environment on Earth, including soil, water, and the human body. In the medical field, bacteria are often studied and classified based on their characteristics, such as their shape, size, and genetic makeup. Bacteria can be either beneficial or harmful to humans. Some bacteria are essential for human health, such as the bacteria that live in the gut and help digest food. However, other bacteria can cause infections and diseases, such as strep throat, pneumonia, and meningitis. In the medical field, bacteria are often identified and treated using a variety of methods, including culturing and identifying bacteria using specialized laboratory techniques, administering antibiotics to kill harmful bacteria, and using vaccines to prevent bacterial infections.

Ticarcillin is a semi-synthetic antibiotic that belongs to the penicillin group of drugs. It is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, skin infections, and infections of the respiratory tract, bones, and joints. Ticarcillin is usually given intravenously or intramuscularly, and it works by inhibiting the growth of bacteria by interfering with their ability to make cell walls. It is often used in combination with other antibiotics to treat more severe or resistant infections. Ticarcillin is generally well-tolerated, but it can cause side effects such as nausea, vomiting, diarrhea, and allergic reactions.

Metronidazole is an antibiotic medication that is commonly used to treat a variety of bacterial and protozoal infections. It is particularly effective against anaerobic bacteria, which are bacteria that thrive in oxygen-poor environments. Metronidazole is often used to treat infections of the gastrointestinal tract, such as giardiasis and trichomoniasis, as well as infections of the vagina, skin, and respiratory tract. It is also sometimes used to treat infections caused by certain types of parasites, such as Entamoeba histolytica. Metronidazole is available in various forms, including tablets, capsules, and creams, and is typically taken orally or applied topically. It is important to follow the instructions of your healthcare provider when taking metronidazole, as it can cause side effects such as nausea, vomiting, and diarrhea.

Cephalosporin resistance refers to the ability of bacteria to resist the effects of cephalosporin antibiotics, a class of drugs commonly used to treat bacterial infections. This resistance can occur due to various mechanisms, such as the production of enzymes that inactivate the antibiotic, changes in the bacterial cell wall that prevent the antibiotic from entering the cell, or mutations in the bacterial DNA that alter the target site of the antibiotic. Cephalosporin resistance is a growing concern in the medical field because it can make infections more difficult to treat and can lead to the spread of antibiotic-resistant bacteria. Infections caused by cephalosporin-resistant bacteria may require more expensive and toxic antibiotics, longer hospital stays, and increased risk of complications and death. Therefore, it is important to use cephalosporin antibiotics judiciously and to follow appropriate infection control measures to prevent the spread of antibiotic-resistant bacteria.

Cefazolin is an antibiotic medication that is used to treat a variety of bacterial infections, including skin infections, respiratory infections, urinary tract infections, and infections of the bones and joints. It is a cephalosporin antibiotic, which means that it works by stopping the growth of bacteria. Cefazolin is usually given intravenously (into a vein) or intramuscularly (into a muscle) and is typically used in hospital settings. It is important to note that cefazolin may not be effective against all types of bacteria, and it is important to use the medication as directed by a healthcare provider.

Penicillins are a group of antibiotics that are derived from the Penicillium fungi. They are one of the most widely used antibiotics in the medical field and are effective against a variety of bacterial infections, including pneumonia, strep throat, and urinary tract infections. Penicillins work by inhibiting the production of cell walls in bacteria, which causes the bacteria to burst and die. There are several different types of penicillins, including penicillin G, penicillin V, amoxicillin, and cephalosporins, which have different properties and are used to treat different types of infections. Penicillins are generally well-tolerated by most people, but can cause side effects such as allergic reactions, diarrhea, and nausea. It is important to take penicillins exactly as prescribed by a healthcare provider and to finish the full course of treatment, even if symptoms improve before the medication is finished.

Penicillanic acid is a chemical compound that is the core structure of many antibiotics, including penicillin. It is a cyclic β-lactam ring with an amino group and a carboxylic acid group. The structure of penicillanic acid is responsible for the antibacterial activity of penicillin and related antibiotics. These antibiotics work by inhibiting the synthesis of bacterial cell walls, leading to cell lysis and death. Penicillanic acid is not used as an antibiotic in its own right, but rather as a precursor to the synthesis of many different antibiotics.

Penicillin-Binding Proteins (PBPs) are enzymes found in the cell walls of bacteria that are responsible for cross-linking peptidoglycan strands, which is a key component of bacterial cell walls. PBPs are targeted by many antibiotics, including penicillins, cephalosporins, and carbapenems, which inhibit their activity and prevent the formation of a stable cell wall, leading to bacterial cell lysis and death. PBPs are classified into several classes based on their molecular weight and substrate specificity. Class A PBPs are the most common and are found in most bacteria, including Gram-positive and Gram-negative bacteria. Class B PBPs are found only in Gram-positive bacteria, while class C PBPs are found only in Gram-negative bacteria. Class D PBPs are found in both Gram-positive and Gram-negative bacteria and are responsible for resistance to beta-lactam antibiotics. In summary, PBPs are essential enzymes for bacterial cell wall synthesis and are targeted by many antibiotics, making them important targets for the development of new antibiotics to combat bacterial infections.

Clavulanic acid is a type of beta-lactamase inhibitor that is used in combination with certain antibiotics to enhance their effectiveness against bacterial infections. Beta-lactamases are enzymes produced by some bacteria that can inactivate beta-lactam antibiotics, such as penicillins and cephalosporins, rendering them ineffective. Clavulanic acid works by binding to beta-lactamases and blocking their activity, allowing the beta-lactam antibiotics to remain active and effective against the bacteria. It is often used in combination with antibiotics such as amoxicillin-clavulanate, ticarcillin-clavulanate, and piperacillin-tazobactam to treat a variety of bacterial infections, including respiratory tract infections, skin infections, and urinary tract infections. Clavulanic acid is available as a prescription medication and is typically taken orally in tablet or capsule form. It is generally well-tolerated, but like all medications, it can cause side effects such as nausea, diarrhea, and allergic reactions.

Penicillinase is an enzyme produced by certain bacteria that is capable of breaking down penicillin antibiotics, rendering them ineffective. Penicillinase is responsible for the development of resistance to penicillin in many bacterial strains, including Staphylococcus aureus and Streptococcus pneumoniae. The production of penicillinase is a mechanism by which bacteria can survive in the presence of penicillin, which would otherwise be lethal to them. In the medical field, penicillinase is an important factor to consider when selecting antibiotics for the treatment of bacterial infections, as it can reduce the effectiveness of penicillin and other beta-lactam antibiotics.

Beta-lactam resistance refers to the ability of bacteria to resist the effects of beta-lactam antibiotics, a class of antibiotics that includes penicillins, cephalosporins, and monobactams. This resistance can occur through various mechanisms, such as the production of beta-lactamase enzymes that break down the antibiotic, the alteration of the target site of the antibiotic, or the reduced permeability of the bacterial cell wall to the antibiotic. Beta-lactam resistance is a major concern in the medical field because it can lead to treatment failure and the spread of antibiotic-resistant infections.

Piperacillin is an antibiotic medication that is used to treat a variety of bacterial infections. It is a beta-lactam antibiotic, which means that it works by inhibiting the growth of bacteria by interfering with their cell walls. Piperacillin is often used in combination with another antibiotic, such as tazobactam, to increase its effectiveness against certain types of bacteria that are resistant to other antibiotics. It is typically administered intravenously, but it can also be given orally in some cases. Piperacillin is used to treat a wide range of infections, including pneumonia, urinary tract infections, and skin infections. It is also sometimes used to prevent infections in people who are at high risk, such as those undergoing surgery or chemotherapy.

"Cefoxitin International". Drugs.com. 2 November 2020. Retrieved 8 November 2020. "Cefoxitin- cefoxitin sodium powder, for ... "Cefoxitin". Drug Information Portal. U.S. National Library of Medicine. "Cefoxitin sodium". Drug Information Portal. U.S. ... "Camrese and cefoxitin Drug Interactions". Drugs.com. Retrieved 2017-05-29. "Cefoxitin and heparin Drug Interactions". Drugs.com ... The generic version of cefoxitin is known as cefoxitin sodium. Groups of researchers at Merck and Lilly discovered Cephamycin C ...
Cefoxitin, Cefotetan, and Other Cephamycins". In M. Lindsay Grayson; Cosgrove, Sara E.; Crowe, Suzanne; Hope, William; McCarthy ...
Cephamycins (cefoxitin and cefotetan) are not hydrolyzed by majority of ESBLs, but are hydrolyzed by associated AmpC-type β- ... such as cefoxitin or cefotetan but are not affected by commercially available β-lactamase inhibitors, and can, in strains with ... cefoxitin and cefotetan); has been blocked by inhibitors such as clavulanate, sulbactam or tazobactam and did not involve ... cefoxitin, cefotetan) but resistance to the third-generation cephalosporins and to aztreonam. Moreover, one should suspect ...
Brown RB, Klar J, Lemeshow S, Teres D, Pastides H, Sands M (November 1986). "Enhanced bleeding with cefoxitin or moxalactam. ...
Susceptible to amikacin, imipenem, cefoxitin, clarithromycin and ciprofloxacin. Resistant to isoniazid and rifampin. ...
ISBN 1-55581-258-9. Little PJ, Peddie BA (July 1978). "Clinical use of cefoxitin, a new semisynthetic cephamycin". N. Z. Med. J ... Cefoxitin Cefotetan Cefmetazole Oreste A. Mascaretti (2003). Bacteria Versus Antibacterial Agents: An Integrated Approach. ...
M. fanklinii is susceptible to cefoxitin and bedaquiline. Nogueira CL, Simmon KE, Chimara E, Cnockaert M, Carlos Palomino J, ...
Teng LJ, Hsueh PR, Tsai JC, Liaw SJ, Ho SW, Luh KT (September 2002). "High incidence of cefoxitin and clindamycin resistance ...
Typical regimens include cefoxitin or cefotetan plus doxycycline, and clindamycin plus gentamicin. An alternative parenteral ... Another alternative is to use a parenteral regimen with ceftriaxone or cefoxitin plus doxycycline. Clinical experience guides ...
Cefoxitin, cefuroxime, cefaclor, cefprozil, and cefmetazole are classed as second-generation cephems. Ceftazidime, ceftriaxone ...
Typical antibiotics used are cefoxitin or cefotetan plus doxycycline, and clindamycin plus gentamicin. An alternative ...
P. gergoviae is also resistant to cefoxitin, likely due to β-lactamase production. Brenner, D. J.; Richard, C.; Steigerwalt, A ...
This bacterium is susceptible to the β-lactam antibiotics imipenem, cefoxitin, and ticarcillin. B. wadsworthia is a Gram- ...
The type strain isolates were susceptible in vitro to ciprofloxacin, amikacin, tobramycin, cefoxitin, clarithromycin, ...
... comparison of cefotetan plus doxycycline and cefoxitin plus doxycycline". American Journal of Obstetrics and Gynecology. 158 (3 ...
Species of the Bacteroidaceae have displayed increasing resistance to antimicrobial agents such as cefoxitin, clindamycin, ...
cefoxitin disc diffusion uses phenotypic resistance to test not only for methicillin resistant strains but also for low ... Anand KB, Agrawal P, Kumar S, Kapila K (2009). "Comparison of cefoxitin disc diffusion test, oxacillin screen agar, and PCR for ...
can be resistant to third-generation cephalosporins, but remain susceptible to imipenem, cefoxitin, and amoxicillin combined ...
Out of the cephalosporins, cefoxitin and cefotetan can be used to cover Gram-positive bacteria, Gram-negative bacteria, and ...
Although cefoxitin disks have been used, oxacillin disks are considered to be much more sensitive, and thus a more accurate ... March 2016). "Evaluation of Oxacillin and Cefoxitin Disk and MIC Breakpoints for Prediction of Methicillin Resistance in Human ...
The resistance of P. penneri to cefuroxime and the marked inhibitory activity of cefoxitin against this species also ... In vitro studies of ceftizoxime, ceftazidime, moxalactam, and cefoxitin suggest these agents also may prove to be clinically ... ceftizoxime ceftazidime moxalactam cefoxitin gentamicin tobramycin netilmicin Most strains with a few exceptions are also ...
... cefoxitin and clarithromycin. They are resistant to isoniazid and rifampicin. M. goodii is found in many of the same settings ...
... cefoxitin, chloramphenicol and clarithromycin, and resistant to isoniazid, rifampin and tobramycin. M. wolinskyi causes human ...
... cefoxitin (INN) cefozopran (INN) cefpimizole (INN) cefpiramide (INN) cefpirome (INN) cefpodoxime (INN) cefprozil (INN) ...
... cefprozil Cefaclor Cefamandole Cefuroxime Cefotetan Cefoxitin Cefixime Cefotaxime Cefpodoxime Ceftazidime Ceftriaxone Cefdinir ...
... cefoxitin MeSH D02.065.589.099.374 - clavulanic acids MeSH D02.065.589.099.374.160 - clavulanic acid MeSH D02.065.589.099. ...
... inhibitor such as amoxicillin/ticarcillin with clavulanic acid or a Beta-lactamase resistant antibiotic such as cefoxitin, ...
Cefatrizine J01DB08 Cefapirin J01DB09 Cefradine J01DB10 Cefacetrile J01DB11 Cefroxadine J01DB12 Ceftezole J01DC01 Cefoxitin ...
... cefoxitin, cefazolin, various sulfonamides, various quinolones, vancomycin, levofloxacin, imipenem, meropenem, pristinamycin ...
... cefoxitin 1977 - cefuroxime 1977 - mezlocillin 1977 - pivmecillinam 1979 - cefaclor 1980 - cefmetazole 1980 - cefotaxime 1980 ...
Cefoxitin Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Cefoxitin injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein). Cefoxitin injection ... Use cefoxitin injection until you finish the prescription, even if you feel better. If you stop using cefoxitin injection too ... Before taking cefoxitin injection,. *tell your doctor and pharmacist if you are allergic to cefoxitin, cephalosporin ...
... and direct cefoxitin disk diffusion (DCDD) test using a 30 μg cefoxitin disk. In parallel, standard microbiological ... As regards the use of DCDD in CoNS isolates, 6/21 isolates (28.6%) with cefoxitin zone sizes 22, 23 or 24 mm (shown in bold ... The materials and expertise needed to perform the DCDD test are just a Muller-Hinton plate and a cefoxitin disk, which already ... Direct tube coagulase and direct cefoxitin disk diffusion test. The tube coagulase test was performed directly from the blood ...
Se liste over medicin, der indeholder Cefoxitin
Call for Availability: 844-603-4063 ext. 1 ...
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Cefoxitin for Injection and Dextrose Injection is a cephalosporin antibacterial indicated for the treatment of the following... ... equivalent to 1.05 gram of cefoxitin sodium) or 2 grams of cefoxitin (equivalent to 2.10 grams of cefoxitin sodium), with a pH ... Cefoxitin for Injection and Dextrose Injection is a sterile, nonpyrogenic, single-dose packaged combination of cefoxitin sodium ... Cefoxitin sodium contains approximately 53.8 mg (2.3 mEq) of sodium per gram of cefoxitin activity. ...
Cefoxitin¶. Yes. Abbreviations: EIA = enzyme immunoassay; GDH = glutamate dehydrogenase; Neg = negative; NT = not tested; PCR ... Patient received a diagnosis of appendicitis and received 1 dose of preoperative cefoxitin before the appendectomy. ...
Cefoxitin 4. S. Ceftazidime <=1. S. Ceftazidime/avibactam 1. <=0.5. S. Ceftazidime/clavulanic acid 1. <=0.5. ---. ...
Cefoxitin 2 g iv. q 6 h. Or. Moxifloxacin 400 mg iv. daily or ciprofloxacin 400 mg iv. q 24 h. Plus. Metronidazole 500 mg q 8 h ... Ticarcillin/clavulanate 3.1 g q 4-6 h or cefoxitin 2 g iv. q 6 h or ertapenem 1 g iv. q 24 h or moxifloxacin 400 mg iv. q 24 h‡ ...
Cefoxitin. ,64. ,64. ,64. ,64. 8. Imipenem. ,16. 4. 2. 2. ,0.5. ...
Type cultures produced low levels of β-lactamase and were susceptible to cefoxitin, latamoxef, imipenem and the combination of ... cefoxitin and latamoxef, but not imipenem, and which were less susceptible to inhibition by β-lactamase inhibitors; (iii) an ... but not cefoxitin, latamoxef or imipenem, and were susceptible to inhibition by β-lactamase inhibitors; (ii) those that ... Cuchural G. J., Tally F. P., Jacobus N. V., Marsh P. K., Mayhew J. W. 1983; Cefoxitin inactivation by Bacteroides fragilis. ...
Oral cephalosporins = cefdinir, cefixime, cefotaxime, cefoxitin, cefpodoxime, ceftibuten, or ceftizoxime.. † Oral ...
FOX-Cefoxitin. Credit: Microorganisms (2023). DOI: 10.3390/microorganisms11041033 ...
cefoxitin. Monitor Closely (1)probenecid will increase the level or effect of cefoxitin by acidic (anionic) drug competition ... cefoxitin. probenecid will increase the level or effect of cefoxitin by acidic (anionic) drug competition for renal tubular ...
Tobi - Get up-to-date information on Tobi side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Tobi
... cefoxitin 2 g IM in a single dose. None of these injectable cephalosporins offers any advantage compared with ceftriaxone, and ...
cefoxitin. Minor (1)cefoxitin increases toxicity of furosemide by pharmacodynamic synergism. Minor/Significance Unknown. ... cefoxitin. cefoxitin increases toxicity of furosemide by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk ...
4) and placed adjacent to a cefoxitin (FOX) disk on a lawn of cefoxitin-susceptible E. coli. The indented zone margin is ... The CLSI ESBL screen can be used to screen for plasmid-mediated AmpC β-lactamases (28). Alternatively, cefoxitin ... By inhibiting AmpC β-lactamases, they potentiate the activity of cephems (usually cefotetan and cefoxitin). Boronic acid-based ... Emergence of resistance to cefamandole: possible role of cefoxitin-inducible beta-lactamases. Antimicrob. Agents Chemother. 15 ...
PHARMAC has resolved to award tenders for Sole Subsidised Supply Status and Hospital Supply Status for some products included in the 2018/19 Invitation to Tender, dated 1 November 2018.
For SPF ApcMin/+ experiments with BF+ slurries, 6- to 10-week-old mice were gavaged with 100 μL of cefoxitin (500 μg/mL) 3 days ... Five microliters of each dilution were spotted onto cycloserine-cefoxitin fructose plates supplemented with 0.1% taurocholate ( ... Reduction of murine colon tumorigenesis driven by enterotoxigenic Bacteroides fragilis using cefoxitin treatment ... prior to inoculation and given cefoxitin (500 mg/L) in their drinking water for 2 days. Following a 1-day wash-out period, mice ...
Since cefoxitin is eliminated almost entirely via the kidney, creatinine clearance was identified as a covariate of cefoxitin ... To ensure cefoxitin target concentrations during surgery, we recommend that cefoxitin be administered every 1.5 h in patients ... Título: Population pharmacokinetics of prophylactic cefoxitin in patients undergoing colorectal surgery Revista: EUROPEAN ... To elucidate whether a dose of 2 g cefoxitin as a prophylactic agent in patients undergoing elective colorectal surgery is able ...
... cefoxitin, and cefuroxime) have an extended antibacterial spectrum that includes greater activity against additional species of ... The second-generation cephalosporins (cefamandole, cefaclor, cefotetan, cefoxitin, and cefuroxime) have an extended ...
Cefoxitin, she had to give up her favorite pastime she had no strength even for ordinary things. Use the missed dose as soon as ...
Stability of intravenous admixtures of aztreonam and cefoxitin, gentamicin, metronidazole, or tobramycin.. ...
  • The second-generation cephalosporins (cefamandole, cefaclor, cefotetan, cefoxitin, and cefuroxime) have an extended antibacterial spectrum that includes greater activity against additional species of gram-negative rods. (britannica.com)
  • Cefoxitin (30g) was used as surrogate to determine phenotypic methicillin resistance in staphylococcus isolates, and the methicillin resistance ( mec A) gene was detected by conventional PCR assay. (who.int)
  • Four of the 9 (44.4%) CoNS isolates were cefoxitin resistant and all the 4 (100%) carried mec A gene. (who.int)
  • Type cultures produced low levels of β-lactamase and were susceptible to cefoxitin, latamoxef, imipenem and the combination of benzylpenicillin and clavulanic acid. (microbiologyresearch.org)
  • Available data from published prospective cohort studies, case series, and case reports over several decades with cephalosporin use, including cefoxitin, in pregnant women have not established drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes (see Data) . (medlibrary.org)
  • While available studies cannot definitively establish the absence of risk, published data from prospective cohort studies, case series, and case reports over several decades have not identified an association with cephalosporin use, including cefoxitin, during pregnancy, and major birth defects, miscarriage, or other adverse maternal or fetal outcomes. (medlibrary.org)
  • Cefoxitin injection may also be used before and during surgery, in order to prevent the patient from getting an infection. (medlineplus.gov)
  • Cefoxitin injection is in a class of medications called cephamycin antibiotics. (medlineplus.gov)
  • Antibiotics such as cefoxitin injection will not work for colds, flu, or other viral infections. (medlineplus.gov)
  • Cefoxitin injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein). (medlineplus.gov)
  • Cefoxitin injection is also available as a premixed product to be injected intravenously. (medlineplus.gov)
  • You may receive cefoxitin injection in a hospital or you may administer the medication at home. (medlineplus.gov)
  • If you will be receiving cefoxitin injection at home, your healthcare provider will show you how to use the medication. (medlineplus.gov)
  • You should begin to feel better during the first few days of treatment with cefoxitin injection. (medlineplus.gov)
  • Use cefoxitin injection until you finish the prescription, even if you feel better. (medlineplus.gov)
  • If you stop using cefoxitin injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
  • Cefoxitin injection is also sometimes used to treat gonorrhea (a sexually transmitted disease). (medlineplus.gov)
  • Also tell your doctor if you are allergic to any of the ingredients in cefoxitin injection. (medlineplus.gov)
  • If you become pregnant while taking cefoxitin injection, call your doctor. (medlineplus.gov)
  • Cefoxitin injection may cause side effects. (medlineplus.gov)
  • In patients with a reduced creatinine clearance the dose of Cefoxitin Injection and Dextrose Injection should be adjusted to compensate for the slower rate of renal elimination. (medlibrary.org)
  • Perioperative use of ampicillin/sulbactam, cefoxitin and piperacillin/ metronidazole in elective colon and rectal surgery. (bvsalud.org)
  • Perioperative Anwendung von Ampicillin/Sulbactam, Cefoxitin und Piperacillin/Metronidazol in der elektiven Colon- und Rectumchirurgie. (bvsalud.org)
  • ABSTRACT We evaluated the utility of 2 methods for detection of methicillin-resistant Staphylococcus aureus (MRSA) directly from signal-positive blood culture bottles: loop-mediated isothermal amplification (LAMP) assay, and direct cefoxitin disk diffusion (DCDD) test using a 30 μg cefoxitin disk. (who.int)
  • For example, Mycobacterium chelonae is almost always resistant to cefoxitin. (cdc.gov)
  • But Mycobacterium franklinii does not exhibit this high level of cefoxitin resistance. (cdc.gov)
  • MRSA was detected using cefoxitin disc and inducible clindamycin resistance detected using D-test. (clin-lab-publications.com)
  • In a published clinical lactation study, the concentration of cefoxitin ranged from 11.6 ± 0.8 to 0.49 ± 0.01 mcg/mL and 1.71 ± 0.08 to 0.57 ± 0.02 mcg/mL in human plasma and breast milk, respectively, at 1, 1.5, 2 or 2.5 hours following IV administration of 1 g cefoxitin twice daily. (medlibrary.org)
  • In the rabbit, cefoxitin was associated with a high incidence of abortion and maternal death. (medlibrary.org)
  • High exposure to VPA can lead to carnitine depletion causing a misbalance between the intra-mitochondrial beta-oxidation and the microsomal co-oxidation, a pathway that produces toxic metabolites such as 4-en-VPA which inhibits ammonia elimination. (unav.edu)
  • This formulation of cefoxitin is indicated for use only in patients who require the entire 1 or 2 gram dose. (medlibrary.org)
  • Combined use of cefoxitin and cefuroxime can alter the milk flora and infant fecal flora. (nih.gov)
  • Studies with cefuroxime and cefoxitin. (nih.gov)
  • We found that 70% of these isolates were ESBLs strains and all of them were resistant to β-lactam antibiotics (ampicillin, piperacillin, cefazolin, cefuroxime, cefotaxime and aztreonam), but most of them were sensitive to another kind of β-lactam antibiotics─cephamycin (cefoxitin and flomoxef). (ncl.edu.tw)
  • Cefoxitin injection is in a class of medications called cephamycin antibiotics. (medlineplus.gov)
  • Antibiotics such as cefoxitin injection will not work for colds, flu, or other viral infections. (medlineplus.gov)
  • If you stop using cefoxitin injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
  • 1. Choice for prophylactic antibiotics: Cefazolin plus metronidazole or cefoxitin alone for endometrial cancer surgical staging. (nih.gov)
  • Cefoxitin for injection contains approximately 53.8 mg (2.3 milliequivalents) of sodium per gram of cefoxitin activity. (nih.gov)
  • Four postpartum women received 1 gram of cefoxitin three times a day. (nih.gov)
  • Cefoxitin for Injection, USP contains sterile cefoxitin sodium, USP equivalent to 1 or 2 grams cefoxitin. (nih.gov)
  • All information about Cefoxitin sodium salt is provided in the MSDS. (alsachim.com)
  • Cefoxitin for injection is a semi-synthetic, broad-spectrum cepha antibiotic sealed under nitrogen for intravenous administration. (nih.gov)
  • Practi-Cefoxitin 2g/20 mL Powder Vial for clinical training simulates 2 g/20 mL of the antibiotic Cefoxitin, a medication used to treat bacterial infections. (anatomywarehouse.com)
  • In these studies, we hypothesized that persistent colonization by ETBF is required for tumorigenesis.We established a method for clearing ETBF in mice, using the antibiotic cefoxitin. (nih.gov)
  • Cefoxitin has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria. (nih.gov)
  • Increase in production of beta-lactamases by cefoxitin can inactivate aztreonam. (medscape.com)
  • Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment. (nih.gov)
  • Transmissible cefoxitin (FX) resistance in Bacteroides vulgatus CLA341 was associated with the 12.5-kb, mobilizable transposon, Tn4555, which encoded the 13-lactamase gene cfxA. (ecu.edu)
  • Genetic and biochemical analysis of a novel Ambler class A β-Lactamase responsible for cefoxitin resistance in Bacteroides species. (ecu.edu)
  • Cefoxitin injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein). (medlineplus.gov)
  • Cefoxitin injection is also available as a premixed product to be injected intravenously. (medlineplus.gov)
  • Fifteen women were given a single 1 gram dose of cefoxitin intravenously at about 1 month after delivery. (nih.gov)
  • Cefoxitin was not measurable in breastmilk at any time up to 6 hours after a single 1 gram intravenous dose of cefoxitin in 2 women. (nih.gov)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of cefoxitin for injection and other antibacterial drugs, cefoxitin for injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • Cefoxitin is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. (nih.gov)
  • Resistance to cefoxitin is primarily through hydrolysis by beta-lactamase, alteration of penicillin-binding proteins (PBPs), and decreased permeability. (nih.gov)
  • But Mycobacterium franklinii does not exhibit this high level of cefoxitin resistance. (cdc.gov)
  • Cefoxitin (30g) was used as surrogate to determine phenotypic methicillin resistance in staphylococcus isolates, and the methicillin resistance ( mec A) gene was detected by conventional PCR assay. (who.int)
  • Comparison of cefazolin and cefoxitin. (nih.gov)
  • However, the efficacy of cefoxitin in treating clinical infections due to these microorganisms has not been established in adequate and well-controlled clinical trials. (nih.gov)
  • Cefoxitin passes into pleural and joint fluids and is detectable in antibacterial concentrations in bile. (nih.gov)
  • 2016. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540097/all/Cefoxitin. (hopkinsguides.com)
  • Eighteen women undergoing cesarean section were given either a single 2 gram dose of cefoxitin or 2 g followed by two 1 gram doses (route unspecified). (nih.gov)
  • Secretion of cefoxitin in breast milk following short-term prophylactic adminstration in caesarean secretion. (nih.gov)
  • Cefoxitin is intended for Pharmaceuticals, Environment, Food & beverage applications. (alsachim.com)
  • Substantial information indicates that cefoxitin produces low levels in milk that are not expected to cause adverse effects in breastfed infants. (nih.gov)
  • After a single 2 gram intramuscular dose of cefoxitin in 5 women, peak milk levels of 0.31 to 0.65 mg/L occurred 1 to 5 hours after the dose. (nih.gov)
  • Cefoxitin was detected (detection limit 0.5 mg/L) in the milk of only one woman at a concentration of 0.9 mg/L 19 hours after the third dose of cefoxitin. (nih.gov)
  • Five women were who had been receiving intravenous cefoxitin 1 gram twice daily for 2 days following cesarean section each donated a milk sample. (nih.gov)
  • We observed a stepwise increase in median colon tumor numbers as the duration of ETBF colonization increased before cefoxitin treatment. (nih.gov)
  • Transmammary passage of cefoxitin: Additional results. (nih.gov)
  • 8. Ceftriaxone Combined With Metronidazole is Superior to Cefoxitin Alone in the Management of Uncomplicated Appendicitis in Children: Results from a Multicenter Collaborative Comparative Effectiveness Study. (nih.gov)
  • In parallel, IL-17A expression was evaluated in wild-type littermates.Cefoxitin treatment resulted in complete and durable clearance of ETBF colonization. (nih.gov)
  • En parallèle, une identification microbiologique normalisée et un test de sensibilité à l'oxacilline par PCR visant l'amplification du gène MecA ont été réalisés. (who.int)
  • 0.8 mg/L) cefoxitin levels. (nih.gov)
  • cefoxitin will increase the level or effect of argatroban by anticoagulation. (medscape.com)
  • cefoxitin will increase the level or effect of fondaparinux by anticoagulation. (medscape.com)
  • cefoxitin will decrease the level or effect of bazedoxifene/conjugated estrogens by altering intestinal flora. (medscape.com)
  • Cefoxitin: A hospital study. (nih.gov)