Cefotiam
Cefazolin
Cefmenoxime
A cephalosporin antibiotic that is administered intravenously or intramuscularly. It is active against most common gram-positive and gram-negative microorganisms, is a potent inhibitor of Enterobacteriaceae, and is highly resistant to hydrolysis by beta-lactamases. The drug has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.
Cefsulodin
Cholera Vaccines
Cholera
Vaccines
Vaccines, Inactivated
Cholera Toxin
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
Drug Information Services
Pamphlets
Drug Labeling
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
Formularies as Topic
Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.
Drug Industry
Medical Records Systems, Computerized
Counterfeit Drugs
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
Quality Assurance, Health Care
Activities and programs intended to assure or improve the quality of care in either a defined medical setting or a program. The concept includes the assessment or evaluation of the quality of care; identification of problems or shortcomings in the delivery of care; designing activities to overcome these deficiencies; and follow-up monitoring to ensure effectiveness of corrective steps.
Contracts
Quality Control
Quality of Life
Lot Quality Assurance Sampling
Encyclopedias as Topic
MedlinePlus
Thermococcus
Consumer Health Information
Social Media
Pyrococcus
Biotechnology
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Moraceae
Sick Sinus Syndrome
A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.
Pacemaker, Artificial
Dichlorodiphenyldichloroethane
Heart Block
Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.
Cardiac Pacing, Artificial
Genetic Code
Drug Utilization
alpha-Macroglobulins
Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.
Inventions
Intellectual Property
Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)
Protection with antibody to tumor necrosis factor differs with similarly lethal Escherichia coli versus Staphylococcus aureus pneumonia in rats. (1/31)
BACKGROUND: Differing factors may alter the effects of antibody to tumor necrosis factor (TNF) in infection and sepsis. The authors tested whether bacteria type or treatment route alters antibody to TNF in a rat model of bacterial pneumonia. METHODS: Rats (n = 231) received similarly lethal doses of either intratracheal Escherichia coli or Staphylococcus aureus followed by treatment with either intratracheal or intraperitoneal antibody to TNF or control serum. Animals received antibiotics (cefotiam daily dose, 100 mg/kg) starting 4 h after inoculation and were studied for up to 96 h. RESULTS: Compared with S. aureus, E. coli increased serum TNF and interleukin-6 concentrations, lung lavage TNF concentrations, neutrophil counts, and alveolar-to-arterial oxygen gradients and decreased circulating neutrophils and lymphocytes (P > or = 0.05 for all). Compared with controls, with both bacteria, except for lung lavage TNF concentrations (which decreased with intratracheal but not with intraperitoneal antibody to TNF), treatment route did not alter the effects of antibody to TNF on any parameter (P = not significant for all). Antibody to TNF reduced mortality rates (relative risk of death +/- SEM) with both E. coli (-1.6 +/- 0.6; P = 0.006) and S. aureus (-0.5 +/- 0.04; P = 0.185), but these reductions were greater with E. coli than with S. aureus in a trend approaching statistical significance (P = 0.09). Compared with controls, similarly (P = not significant) with both bacteria, antibody to TNF decreased lung lavage and tissue bacteria concentrations (both P < 0.05) and serum TNF concentration (P < 0.09) and increased circulating neutrophils and lymphocytes (both P < or = 0.01). Compared with S. aureus, with E. coli antibody to TNF decreased alveolar-to-arterial oxygen gradients (P = 0.04) and increased serum interleukin-6 concentrations (P = 0.003). CONCLUSION: Antibody to TNF improved host defense and survival rates with both lethal E. coli and S. aureus pneumonia, but protection was greater with E. coli, where TNF concentrations were higher than with S. aureus. The efficacy of antiinflammatory agents in sepsis may be altered by bacteria type. (+info)Cl- -dependent upregulation of human organic anion transporters: different effects on transport kinetics between hOAT1 and hOAT3. (2/31)
Chloride ion has a stimulatory effect on the transport of organic anions across renal basolateral membranes. However, the exact mechanisms at molecular levels have been unclear as of yet. Human organic anion transporters hOAT1 and hOAT3 play important roles in renal basolateral membranes. In this study, the effects of Cl(-) on the activities of these transporters were evaluated by using HEK293 cells stably expressing hOAT1 or hOAT3 (HEK-hOAT1 or HEK-hOAT3). The uptake of p-[(14)C]aminohippurate by HEK-hOAT1 and [(3)H]estrone sulfate by HEK-hOAT3 was greater in the presence of Cl(-) than in the presence of SO(4)(2-) or gluconate. Additionally, the uptake of various compounds by HEK-hOAT1 and HEK-hOAT3 was significantly higher in the Cl(-)-containing medium than the gluconate-containing medium, suggesting that the influences of Cl(-) are not dependent on substrate and that Cl(-) directly stimulates the functions of hOAT1 and hOAT3. The substitution of gluconate with Cl(-) did not change the K(m) value for the uptake of p-[(14)C]aminohippurate by HEK-hOAT1 but caused an approximately threefold increase in the maximal uptake rate (V(max)) value. On the other hand, replacement of gluconate with Cl(-) decreased the K(m) value for the uptake of [(3)H]estrone sulfate and cefotiam by HEK-hOAT3 to about one-third, while it did not change the V(max) value. In summary, Cl(-) upregulates the activities of both hOAT1 and hOAT3, but its effects on transport kinetics differ between these transporters. It was suggested that Cl(-) participates in the trans-location process for hOAT1, and the substrate recognition process for hOAT3. (+info)Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis. (3/31)
(+info)Multidrug-resistant Neisseria gonorrhoeae with reduced cefotaxime susceptibility is increasingly common in men who have sex with men, Amsterdam, the Netherlands. (4/31)
Antimicrobial resistance is an increasing problem in Neisseria gonorrhoeae (NG) treatment. Presently, third-generation parenteral cephalosporins, like ceftriaxone and cefotaxime, are the first option. Resistance to oral, but not to parenteral, third-generation cephalosporins has been reported previously. We analysed the microbial susceptibility (as minimum inhibitory concentration - MIC) of NG cultures obtained from high-risk visitors of the largest Dutch outpatient clinic for sexually transmitted infections (STI) in Amsterdam, the Netherlands. Among 1,596 visitors, we identified 102 patients with at least one NG isolate with reduced susceptibility to cefotaxime (0.125 microg/ml < MIC < or = 0.5 microg/ml). The percentage of NG isolates with reduced susceptibility to cefotaxime rose from 4.8% in 2006 to 12.1% in 2008 (chi2 17.5, p<0.001). With multivariate logistic regression, being a man who has sex with men (MSM) was significantly associated with reduced susceptibility to cefotaxime (p<0.001). Compared to susceptible NG isolates, those with decreased susceptiblity to cefotaxime were more often resistant also to penicillin (16.5% vs. 43.3%), tetracycline (21.5% vs. 68.9%) and ciprofloxacin (44.4% vs. 90.0%, all p<0.001). The increased prevalence of NG strains with reduced susceptibility to cefotaxime among MSM may herald resistance to third-generation parenteral cephalosporins. A considerable proportion of these strains show resistance to multiple antibiotics which could limit future NG treatment options. (+info)Molecular-weight-dependent, anionic-substrate-preferential transport of beta-lactam antibiotics via multidrug resistance-associated protein 4. (5/31)
(+info)Interaction of cefpirome and a cephalosporinase from Citrobacter freundii GN7391. (6/31)
The interaction of cefpirome and a cephalosporinase from Citrobacter freundii, including hydrolysis and inhibition, was studied in comparison with those of cefotiam, cefotaxime, and ceftazidime. Cefpirome was hydrolyzed by the enzyme more rapidly at Vmax than were cefotaxime and ceftazidime. However, the low affinity of the enzyme for cefpirome caused a reduction in the hydrolytic rate of cefpirome at a low drug concentration (0.1 microM). The high stability of cefpirome at a low concentration explains the high antimicrobial activity of the agent against cephalosporinase-producing bacteria. (+info)Cefotiam disposition in markedly obese athlete patients, Japanese sumo wrestlers. (7/31)
Markedly obese athletes like Japanese sumo wrestlers may frequently suffer various traumas which result in the prophylaxis or treatment of posttraumatic infection with antibiotics. However, appropriate dosage regimens in this group of patients have not been fully known for many antibiotics. Therefore, we studied the kinetic disposition of cefotiam, a parenteral, broad-spectrum cephalosporin with activity against gram-positive and -negative bacteria, after an intravenous dose (2 g) infused over 30 min into 15 sumo wrestler patients with an excess body weight (130 to 220% of ideal body weight) and 10 control patients with a normal weight (90 to 102% of ideal body weight). Mean (+/- standard deviation) clearance and steady-state volume of distribution were significantly greater in the sumo wrestler than in the control group (38.3 +/- 9.4 versus 23.5 +/- 6.0 liters/h, P less than 0.001, and 30.2 +/- 8.0 versus 17.9 +/- 6.1 liters, P less than 0.001). Mean elimination half-life was slightly but significantly longer in the sumo wrestler than in the control group (0.91 +/- 0.14 versus 0.74 +/- 0.20 h, P less than 0.05). However, mean residence time did not differ between the two groups (0.79 +/- 0.10 versus 0.75 +/- 0.14 h). The statistical differences in clearance and volume of distribution between the two groups disappeared when these kinetic parameters were corrected for body surface area, but not for total body weight or ideal body weight. The results suggest that the dosage calculation of cefotiam, a hydrophilic antibiotic, should be made on the basis of body surface area in morbidly obese athlete or sumo wrestler patients. However, whether this recommendation should extend to other nonathlete obese subjects remains to be determined. (+info)In vitro evaluation of E1040, a new cephalosporin with potent antipseudomonal activity. (8/31)
E1040 is a new parenteral cephalosporin with a broad antibacterial spectrum and potent antipseudomonal activity. The compound was four- to eightfold more active than ceftazidime and cefsulodin against Pseudomonas aeruginosa (MIC of E1040 for 90% of strains tested [MIC90], 3.13 micrograms/ml). E1040 also showed a potent activity against other glucose-nonfermentative rods, including Acinetobacter species. The activities of E1040 against most species of the family Enterobacteriaceae were roughly comparable to the activities of ceftazidime and cefmenoxime and exceeded that of cefotiam. Against Citrobacter freundii (MIC90, 0.78 micrograms/ml), Enterobacter cloacae (MIC90, 3.13 micrograms/ml), and Enterobacter aerogenes (MIC90, 0.2 micrograms/ml), E1040 was 16- to 256-fold more active than ceftazidime and cefmenoxime. The activities of E1040 against gram-positive cocci and anaerobes were comparable to those of ceftazidime, but the compound was less active than cefmenoxime. E1040 was at least as resistant as ceftazidime and cefmenoxime to hydrolysis by various beta-lactamases and showed high affinities for penicillin-binding protein 3 of both Escherichia coli and P. aeruginosa. (+info)
Synthesis and biological screening of 5-{[(4,6-disubstituted pyrimidine-2-yl)thio]methyl}-N-phenyl-1,3,4-thiadiazol-2-amines
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Ceforanide
Cefotiam Crowle A, Sbarbaro J, May M (1988). "Effects of isoniazid and of ceforanide against virulent tubercle bacilli in ...
Discovery and development of cephalosporins
The aminothiazole ring can be seen in the structure of Cefotiam. The majority of third generation cephalosporins have the ...
ATC kod J01
J01DC07 Cefotiam. J01DC08 Lorakarbef. J01DC09 Cefmetazol. J01DC10 Cefprozil. J01DC11 Ceforanid. J01DC12 Cefminoks. J01DC13 ...
List of drugs: Cb-Ce
... cefotiam (INN) cefovecin sodium (USAN) cefoxazole (INN) cefoxitin (INN) cefozopran (INN) cefpimizole (INN) cefpiramide (INN) ...
ATC code J01
J01DC01 Cefoxitin J01DC02 Cefuroxime J01DC03 Cefamandole J01DC04 Cefaclor J01DC05 Cefotetan J01DC06 Cefonicide J01DC07 Cefotiam ...
Timeline of antibiotics
... cefotiam 1981 - cefsulodin 1981 - latamoxef 1981 - netilmicin 1982 - ceftriaxone 1982 - micronomicin 1983 - cefmenoxime 1983 - ...
Cefotiam
... has a broad spectrum of activity and has been used to treat infections caused by a number of enteric bacteria and ... Cefotiam is a parenteral second-generation cephalosporin antibiotic. It has broad-spectrum activity against Gram-positive and ... Cefotiam inhibits final cross-linking stage of peptidoglycan production, thus inhibiting bacterial cell wall synthesis. It has ... Kolben M, Mandoki E, Ulm K, Freitag K (2001). "Randomized trial of cefotiam prophylaxis in the prevention of postoperative ...
Cefuroxime axetil
InChI=1S/C20H22N4O10S/c1-9(25)33-10(2)34-19(28)15-11(7-32-20(21)29)8-35-18-14(17(27)24(15)18)22-16(26)13(23-30-3)12-5-4-6-31-12/h4-6,10,14,18H,7-8H2,1-3H3,(H2,21,29)(H,22,26)/b23-13-/t10?,14-,18-/m1/ ...
Benzylpenicillin
The production of benzylpenicillin involves fermentation, recovery and purification of the penicillin.[10] The fermentation process of the production of benzylpencillin is about obtaining the product. The presence of the product in solution inhibits the reaction and reduces the product rate and yield. Thus, in order to obtain the most product and increase the rate of reaction the product, would be continuously extracted out.[11] This is done by having the mold with either glucose, sucrose, lactose, startch, or detrin, nitrate, ammonium salt, corn steep liquor, peptone, meat or yeast extract, and little amounts of inorganic salts.[12] The recovery of the benzylpencillin is the most important part of the production process because it affects the purification steps if done wrong.[10] There are many different types of techniques to recover benzyl penicillin, aqueous two-phase extraction, liquid membrane extraction, microfiltration technique, and solvent subulation[10] Extraction is more commonly ...
Meropenem
... , sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections.[1] Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax.[1] It is given by injection into a vein.[1] Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection.[1] Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis.[1] Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem.[1] Use in pregnancy appears to be safe.[1] It is in the carbapenem family of medications.[1] Meropenem usually results in bacterial death through blocking their ability to make a cell wall.[1] It is more resistant to breakdown β-lactamase producing bacteria.[1] Meropenem was patented in 1983.[2] It was approved for medical use in the United States in 1996.[1] It is on the World Health ...
Cefetamet
InChI=1S/C14H15N5O5S2/c1-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24-2)6-4-26-14(15)16-6/h4,8,12H,3H2,1-2H3,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/ ...
Nafcillin
Bonow RO, Carabello BA, Kanu C, et al. (August 2006). "ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons". Circulation. 114 (5): e84-231. doi:10.1161/CIRCULATIONAHA.106.176857. PMID 16880336 ...
Phenoxymethylpenicillin
Penicillin V is sometimes used in the treatment of odontogenic infections.. It is less active than benzylpenicillin (penicillin G) against Gram-negative bacteria.[9][10] Phenoxymethylpenicillin has a range of antimicrobial activity against Gram-positive bacteria that is similar to that of benzylpenicillin and a similar mode of action, but it is substantially less active than benzylpenicillin against Gram-negative bacteria.[9][10]. Phenoxymethylpenicillin is more acid-stable than benzylpenicillin, which allows it to be given orally.. Phenoxymethylpenicillin is usually used only for the treatment of mild to moderate infections, and not for severe or deep-seated infections since absorption can be unpredictable. Except for the treatment or prevention of infection with Streptococcus pyogenes (which is uniformly sensitive to penicillin), therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response.[11] People treated initially with parenteral ...
Ceftolozane
The in vitro activity of ceftolozane-tazobactam has been examined in five surveillance studies of isolates from Europe and North America.[8] In these studies, ceftolozane-tazobactam was notable for its activity against Pseudomonas aeruginosa, a moderately common cause of hospital-acquired infections that is commonly multi-drug resistant. Ninety percent of P. aeruginosa isolates were inhibited by a ceftolozane-tazobactam at a concentration of 4 μg/mL (MIC90), making it the most potent anti-pseudomonal antibiotic in clinical use. In these same studies, ceftolozane-tazobactam exhibited MIC90 values of ,1 μg/mL for Escherichia coli, Citrobacter koseri, Morganella morganii, Proteus mirabilis, Salmonella species, and Serratia marcescens. Somewhat poorer activity is observed for the Klebsiella and Enterobacter species, with the MIC90 for extended spectrum beta-lactamase (ESBL) expressing Klebsiella pneumonia being ,32 μg/mL. ...
Vancomycin
A set of multienzymes (peptide synthase CepA, CepB, and CepC) are responsible for assembling the heptapeptide. (Figure 2). The organization of CepA, CepB, and Cep C closely resembles other peptide synthases such as those for surfactin (SrfA1, SrfA2, and SrfA3) and gramicidin (GrsA and GrsB).[41] Each peptide synthase activates codes for various amino acids to activate each domain. CepA codes for modules 1, 2, and 3. CepB codes for modules 4, 5, and 6, and CepC codes for module 7. The three peptide synthases are located at the start of the region of the bacterial genome linked with antibiotic biosynthesis, and span 27 kb.[41]. After the linear heptapeptide molecule is synthesized, vancomycin has to undergo further modifications, such as oxidative cross-linking and glycosylation, in trans[clarification needed] by distinct enzymes, referred to as tailoring enzymes, to become biologically active (Figure 3). To convert the linear heptapeptide, eight enzymes, open reading frames (ORFs) 7, 8, 9, 10, ...
Cefminox
InChI=1S/C16H21N7O7S3/c1-22-15(19-20-21-22)33-4-7-3-32-14-16(30-2,13(29)23(14)10(7)12(27)28)18-9(24)6-31-5-8(17)11(25)26/h8,14H,3-6,17H2,1-2H3,(H,18,24)(H,25,26)(H,27,28)/t8-,14-,16+/m1/s1 ‹See TfM› ...
Cefdinir
... (SEF-di-nir) is a third-generation oral cephalosporin antibiotic sold under the brand names Cefzon and Omnicef. As of 2008, cefdinir, as Omnicef, was the highest-selling cephalosporin antibiotic in the United States, with more than US$585 million in retail sales of its generic versions alone.[1] Cefdinir is structurally similar to cefixime. It was discovered by Fujisawa Pharmaceutical Co., Ltd. (now Astellas) and introduced in 1991 under the brand name Cefzon.[2][3] Warner-Lambert licensed this cephalosporin for marketing in US from Fujisawa.[4] Abbott obtained U.S. marketing rights to Omnicef (cefdinir) in December 1998 through an agreement with Warner-Lambert Company.[5] It was approved by FDA on Dec 4, 1997.[6] It is available in US as Omnicef by Abbott Laboratories and in India as Cednir by Abbott, Kefnir by Glenmark, Cefdair by Xalra Pharma and Cefdiel by Ranbaxy. ...
Ceftolozane/tazobactam
Ceftolozane exerts bactericidal activities against susceptible gram-negative and gram-positive infections by inhibiting essential penicillin-binding proteins (PBPs), which are required for peptidoglycan cross-linking for bacterial cell wall synthesis, resulting in inhibition of cell wall synthesis and subsequent cell death. Ceftolozane is an inhibitor of PBPs of Pseudomonas aeruginosa (e.g. PBP1b, PBP1c, and PBP3) and E. coli (e.g., PBP3).[6][7] Tazobactam is a potent β-lactamase inhibitor of most common class A and C β-lactamases. Tazobactam has little clinically relevant in vitro activity against bacteria due to its reduced affinity to penicillin-binding proteins; however, it is an irreversible inhibitor of some β-lactamases (certain penicillinases and cephalosporinases) and can covalently bind to some chromosomal and plasmid-mediated bacterial beta-lactamases.[6] The addition of tazobactam strengthens the therapeutic response to ceftolozane, giving it the ability to treat a broader range ...
Cefprozil
... is a second-generation cephalosporin antibiotic. It can be used to treat ear infections, skin infections, and other bacterial infections.[citation needed] It comes as a tablet and as a liquid suspension. Although there is a widely quoted cross-allergy risk of 10% between cephalosporins and penicillin, an article[1] has shown no increased risk for cross-allergy for cefprozil and several other second-generation or later cephalosporins. It was patented in 1983 and approved for medical use in 1992.[2] ...
Imipenem/cilastatin
... has the ability to kill a wide variety of bacteria. Imipenem is the active antibiotic agent and works by interfering with their ability to form cell walls, so the bacteria break up and die. Imipenem is rapidly degraded by the renal enzyme dehydropeptidase if administered alone (making it less effective); the metabolites can cause kidney damage.[11] Imipenem is a broad-spectrum betalactam antibiotic used for severe bacterial infections caused by susceptible organisms. Because imipenem is rapidly inactivated by renal dehydropeptidase I, it is given in combination with cilastatin, a DHP-I inhibitor which increases half-life and tissue penetration of imipenem. Imipenem/cilastatin, like other carbapenems, binds to bacterial penicillin-binding proteins and interferes with bacterial cell wall integrity and synthesis. It has activity against many aerobic and anaerobic Gram-positive and Gram-negative organisms, including Staphylococcus aureus, Streptococcus pyogenes, S. agalactiae, S. ...
Aminoglicozidă
Cefotaximă# • Ceftriaxonă# • Cefiximă# • Cefoperazon㇠• Cefotiam • Ceftazidimă# • Ceftizoximă • Ceftibuten • Cefditoren ( ...
Stampa:Penicillin
Cefaclor • Cefamandole • Cefminox • Cefonicid • Ceforanide • Cefotiam • Cefprozil • Cefbuperazone • Cefuroxime • Cefuzonam • ...
اسپکتینومایسین - ویکیپدیا
InChI=1S/C14H24N2O7/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14/h5,7-13,15-16,18-20H,4H2,1-3H3/t5-,7-,8+,9+,10+,11-,12-,13+,14+/m1/s1 ...
سفتریاکسون - ویکیپدیا
سفتریاکسون (آیوپاک آدی: (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-,2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, اینگیلیسجه: Ceftriaxone, (چینجه:頭孢曲松)، عربجه: سيفترياكسون، روسجا: Цефтриаксон) بیر شیمیایی بیلشیک دواء. بۇ دواءنین مول جرمیسی مول/قرم ۵۵۴٫۵۸ دیر. نیمه عمر یا یاریلانما سۆرعتی ۵٫۸-۸٫۷ ساعات زامان آپاریر و آنتیبیوتیک اۆچون ایستیفاده اوْلونور. ...
سیکلوسرین - ویکیپدیا
سیکلوسرین (آیوپاک آدی: (R)-4-Amino-1,2-oxazolidin-3-one, اینگیلیسجه: Cycloserine, عربجه: سيكلوسيرين، روسجا: Циклосерин) بیر شیمیایی بیلشیک دواء. بۇ دواءنین مول جرمیسی مول/قرم ۱۰۲٫۰۹۲ دیر. متابولیسمی قاراجییرده باش وئریر. سیکلوسرین آنتیبیوتیک اۆچون ایستیفاده اوْلونور. ...
اسید نالیدیکسیک - ویکیپدیا
اسید نالیدیکسیک (آیوپاک آدی: 1-Ethyl-7-methyl-4-oxo-[1,8]naphthyridine-3-carboxylic acid, اینگیلیسجه: Nalidixic acid, عربجه: حمض الناليديكسيك، روسجا: Налидиксовая кислота) بیر شیمیایی بیلشیک دواء. بۇ دواءنین مول جرمیسی مول/قرم ۲۳۲٫۲۳۵ دیر. متابولیسمی قاراجییرده باش وئریر. اسید نالیدیکسیک آنتیبیوتیک اۆچون ایستیفاده اوْلونور. ...
বিটা ল্যাক্টাম - উইকিপিডিয়া
Cefaclor • Cefamandole • Cefminox • Cefonicid • Ceforanide • Cefotiam • Cefprozil • Cefbuperazone • Cefuroxime • Cefuzonam • ...
سیلور سولفادیازین - ویکیپدیا
سیلور سولفادیازین (آیوپاک آدی: Silver [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide, اینگیلیسجه: Silver sulfadiazine, (چینجه:磺胺嘧啶银)) بیر شیمیایی بیلشیک دواء. بۇ دواءنین مول جرمیسی مول/قرم ۳۵۷٫۱۴ دیر. سیلور سولفادیازین آنتیبیوتیک اۆچون ایستیفاده اوْلونور. ...
استرپتومایسین - ویکیپدیا
InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1 ...
Cefotiam - Wikipedia
Cefotiam has a broad spectrum of activity and has been used to treat infections caused by a number of enteric bacteria and ... Cefotiam is a parenteral second-generation cephalosporin antibiotic. It has broad-spectrum activity against Gram-positive and ... Cefotiam inhibits final cross-linking stage of peptidoglycan production, thus inhibiting bacterial cell wall synthesis. It has ... Kolben M, Mandoki E, Ulm K, Freitag K (2001). "Randomized trial of cefotiam prophylaxis in the prevention of postoperative ...
Cefradol (Cefotiam Hydrochloride) Ferron
Fodiclo (Cefotiam Dihydrochloride) Interbat
TRC | Details of CAS = 95789-30-3, ChemicalName = Cefotiam Hexetil Hydrochloride (mixture of Diastereomers), synonym = (6R,7R)...
Cefotiam
... 1-(Cyclohexyloxycarbonyloxy)ethyl ester dihydrochloride,Cefotiam hexetil hydrochloride,SCE-2174,Pansporin T,Taketiam, ... Cefotiam Dihydrochloride,Abbott 48999,CGP-14221/E,Halospor,Pansporin,Pansporine,Spizef,Sporidyn,1-(Cyclohexyloxycarbonyloxy) ... Cefotiam,(6R,7R)-7-[[(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]-thio]methyl]-8-oxo-5- ...
Cefotiam - A-Z Medication - Benefits of
Cefotiam is usually referred to as a drug within the type of salt. These ... Cefotiam is a drug used for prophylaxis surgical an infection, prone an infection. ... Whats cefotiam for?. Cefotiam is a drug used for prophylaxis surgical an infection, prone an infection. Cefotiam is usually ... How is cefotiam saved?. Cefotiam is a drug thats finest stored at room temperature, away from direct gentle and damp locations ...
Cefotiam hcl
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Anti-Bacterial Agents, ATC:J01DC07
Cefotiam hcl Dosage Forms Injection and infusion Cefotiam hcl Indication For treatment of severe infections caused by ... Cefotiam hcl Patient Information No information avaliable Cefotiam hcl Organisms Affected Enteric bacteria and other eubacteria ... Cefotiam hcl Pharmacology Cefotiam is a third generation beta-lactam cephalosporin antibiotic. It has broad spectrum activity ... Cefotiam works by inhibiting bacterial cell wall biosynthesis. Cefotiam hcl Absorption Rapidly absorbed following intramuscular ...
A case of cefotiam-contact anaphylaxis | Korean Journal of Medicine;: S238-S242, 2009. | WPRIM
Cefotiam is a second-generation cephalosporin developed in Japan, and cefotiam-induced contact urticaria and systemic symptoms ... Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Urticaria / Humans / Cefotiam / Sulbactam / ... Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Urticaria / Humans / Cefotiam / Sulbactam / ... Anaphylaxis , Anti-Bacterial Agents , Cefoperazone , Cefotiam , Humans , Hypotension , Japan , Korea , Skin , Sulbactam , ...
Compound Report Card
ChEMBL Compound Description] ID:, InChI_Key:, Tradenames:CERADON , Pansporin, Synonyms:CGP-14221/E , CEFOTIAM HEXETIL ... HYDROCHLORIDE , ABBOTT-48999 , CEFOTIAM HYDROCHLORIDE , SCE 963 , CERADON , Pansporin , Ceradon , CEFOTIAM ... CEFOTIAM. ChEMBL Synonyms CGP-14221/E , CEFOTIAM HEXETIL HYDROCHLORIDE , ABBOTT-48999 , CEFOTIAM HYDROCHLORIDE , SCE 963 , ...
Cholera Vaccine (Oral Route) Description and Brand Names - Mayo Clinic
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this vaccine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Receiving this vaccine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.. ...
Vaxchora Advanced Patient Information - Drugs.com
Haneda Y[au] - PubMed - NCBI
SLC22A6 Gene - GeneCards | S22A6 Protein | S22A6 Antibody
Free Pharmacology Flashcards about Parenterals
Penicillin-binding protein 1A - DrugBank
CiNii Articles - 後藤 陽一郎
CiNii Articles - HASEGAWA Satoshi
Ceforanide - Wikipedia
出展社詳細
ATC kod J01 - Wikipedia
Furosemide (Professional Patient Advice) - Drugs.com
Antiinfectives | SCBT - Santa Cruz Biotechnology
WHOCC - DDD alterations
Subkutane Kalzifikationen nach Strahlentherapie | SpringerLink
Frontiers | The Synergistic Effect of Mud Crab Antimicrobial Peptides Sphistin and Sph12−38 With Antibiotics Azithromycin and...
Penicillin, ceftizoxime, and cefotiam are all β-lactam antibiotics. They can inhibit peptide bond formation by competitively ... Among the remaining four antibiotics, the three antibiotics including penicillin, ceftizoxime, and cefotiam are all β-lactam ... In the clinic, penicillin, ceftizoxime, cefotiam, and vancomycin are usually used to treat Gram-positive bacterial infections. ... However, for other antibiotics, including vancomycin, penicillin, ceftizoxime, cefotiam, clindamycin, and tinidazole, when they ...
US Patent # 9,566,348. Methods and compositions for the treatment of cancer and infectious
disease using alpha(2)...
CA2704853C - Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties
- Google...
Hydrochloride2
- We herein report a case of occupational contact urticaria syndrome induced by cefotiam di-hydrochloride in a nurse. (koreamed.org)
- A scratch patch test with cefotiam di-hydrochloride, a major component of cefotiam ingredient showed multiple erythema and wheals within 5 minutes, accompanied by palpitations and tachypnea. (koreamed.org)
Cefaclor2
- Cefuroxime, cefotiam and cefaclor are important substances of the second generation of Cephalosporins. (urology-textbook.com)
- 1) Antimicrobial activity: The minimum inhibitory concentrations (MICs) of LCBF were measured in 302 clinically isolated strains, and compared with those of cefaclor, cefotiam, cefixime, cefteram and amoxicillin, using the MIC-2000 system. (elsevier.com)
Contact urticaria syndrome3
- Cefotiam is a second-generation cephalosporin developed in Japan , and cefotiam -induced contact urticaria and systemic symptoms (contact urticaria syndrome ) have been reported in several nurses from Japan and Korea . (bvsalud.org)
- We describe a case of cefotiam -induced contact anaphylactic shock combined with cefoperazone / sulbactam -induced contact urticaria syndrome in a 24-year-old nurse . (bvsalud.org)
- Based on her clinical history and scratch test result, we diagnosed her condition as contact urticaria syndrome caused by cefotiam. (koreamed.org)
Cefoperazone1
- She exhibited positive skin prick test responses to both cefotiam and cefoperazone / sulbactam . (bvsalud.org)
19881
- Cefotiam Crowle A, Sbarbaro J, May M (1988). (wikipedia.org)
Antibiotics4
- SRP has been shown to enhance the activity of several antibiotics including ampicillin, ciclacillin, cephalexin, minocylcine and cefotiam. (ijpsonline.com)
- A 1999 study examined the biodegradability of the antibiotics cefotiam , ciprofloxacin, meropenem , penicillin G , and sulfamethoxazole as well as their toxicity to bacteria. (sourcewatch.org)
- One study examined the biodegradability of the antibiotics cefotiam , ciprofloxacin , meropenem , penicillin G , and sulfamethoxazole as well as their toxicity to bacteria. (sourcewatch.org)
- Serrapeptase has also been clinically studied and shown effective for the treatment of chronic bronchitis and venous inflammatory disease, and improving the effects of the antibiotics ofloxacin, cephalexin, and cefotiam. (forresthealth.com)
Parenteral2
- Cefotiam is a parenteral second-generation cephalosporin antibiotic. (wikipedia.org)
- The accumulation and the apical-to-basolateral transport of cephradine, cephalexin and cefixime, all p.o. agents, were significantly higher than those of cefotiam, a parenteral agent. (aspetjournals.org)
Flomoxef3
- Cefepime (CFPM), cefotiam (CTM), cefozopran (CZOP), and flomoxef (FMOX) were each administered to 8â€"10. (ebscohost.com)
- and Streptococcus pneumoniae, TOC-39 was twice as active as or more active than cefotiam, ceftazidime, flomoxef, and cefpirome. (asm.org)
- Against Streptococcus pyogenes, TOC-39 was superior to cefotiam, ceftazidime, and flomoxef and was similar to cefpirome. (asm.org)
Prophylaxis1
- Cefotiam is a drug used for prophylaxis surgical an infection , prone an infection. (benefits-of.com)
Chemical1
- cefotiam, Takeda Chemical Industries, Ltd. (asm.org)
Infections1
- Cefotiam has a broad spectrum of activity and has been used to treat infections caused by a number of enteric bacteria and bacteria responsible for causing skin infections. (wikipedia.org)
Renal3
- La muerte celular programada y la fibrosis renal son procesos inherentes a la enfermedad renal crónica y, en tal sentido, ha sido recientemente descripta una clara desregulación de la maquinaria respiratoria mitocondrial en pacientes con enfermedad renal crónica asociada con un aumento del estrés oxidativo. (bvsalud.org)
- La angiotensina II desempeña un papel central en la fibrogénesis renal y conduce a una rápida progresión de la enfermedad renal crónica. (bvsalud.org)
- Por lo tanto, existiría un papel determinante de las mitocondrias y el estrés oxidativo en el proceso inflamatorio renal. (bvsalud.org)
Drug3
- Cefotiam is usually referred to as a drug within the type of salt. (benefits-of.com)
- Cefotiam is a drug that have to be consumed with meals or injected. (benefits-of.com)
- Cefotiam is a drug that's finest stored at room temperature, away from direct gentle and damp locations. (benefits-of.com)